WorldWideScience

Sample records for cancer control framework

  1. A Framework for Training Transdisciplinary Scholars in Cancer Prevention and Control.

    Science.gov (United States)

    James, Aimee S; Gehlert, Sarah; Bowen, Deborah J; Colditz, Graham A

    2015-12-01

    Traditionally, postdoctoral training programs largely have focused efforts within a single discipline or closely related fields. Yet, addressing the complex questions around cancer prevention and control increasingly requires the ability to work and communicate across disciplines in order to gain a perspective that encompasses the multilevel and multifaceted issues involved with this public health issue. To address this complexity, a transdisciplinary training program was implemented to cultivate the professional and scientific development of the postdoctoral fellows in Washington University in St Louis School of Medicine's Division of Public Health Sciences and NCI-funded centers (Community Networks Program Center and Transdisciplinary Research in Energetics in Cancer Center). Fellows are matched with primary mentors and assemble a multidisciplinary mentoring team. Structured programs support the transition of fellows from disciplinary trainees to independent transdisciplinary scholars and provide exposure to multiple disciplines. This article describes the training program, challenges encountered in implementation, solutions to those problems, and the metrics employed to evaluate the program's success. The goal of the program is to train emerging investigators in the conceptual bases, language, and practices that underlie a transdisciplinary perspective on cancer prevention and control research, to create an infrastructure for continued cross-discipline dialogue and collaboration, and to develop disseminable strategies for such training.

  2. A Framework for Training Transdisciplinary Scholars in Cancer Prevention and Control.

    Science.gov (United States)

    James, Aimee S; Gehlert, Sarah; Bowen, Deborah J; Colditz, Graham A

    2015-12-01

    Traditionally, postdoctoral training programs largely have focused efforts within a single discipline or closely related fields. Yet, addressing the complex questions around cancer prevention and control increasingly requires the ability to work and communicate across disciplines in order to gain a perspective that encompasses the multilevel and multifaceted issues involved with this public health issue. To address this complexity, a transdisciplinary training program was implemented to cultivate the professional and scientific development of the postdoctoral fellows in Washington University in St Louis School of Medicine's Division of Public Health Sciences and NCI-funded centers (Community Networks Program Center and Transdisciplinary Research in Energetics in Cancer Center). Fellows are matched with primary mentors and assemble a multidisciplinary mentoring team. Structured programs support the transition of fellows from disciplinary trainees to independent transdisciplinary scholars and provide exposure to multiple disciplines. This article describes the training program, challenges encountered in implementation, solutions to those problems, and the metrics employed to evaluate the program's success. The goal of the program is to train emerging investigators in the conceptual bases, language, and practices that underlie a transdisciplinary perspective on cancer prevention and control research, to create an infrastructure for continued cross-discipline dialogue and collaboration, and to develop disseminable strategies for such training. PMID:25510368

  3. Framework for control system development

    International Nuclear Information System (INIS)

    Control systems being developed for the present generation of accelerators will need to adapt to changing machine and operating state conditions. Such systems must also be capable of evolving over the life of the accelerator operation. In this paper we present a framework for the development of adaptive control systems

  4. The Joint COntrols Project Framework

    CERN Document Server

    González-Berges, M

    2003-01-01

    The Framework is one of the subprojects of the Joint COntrols Project (JCOP), which is collaboration between the four LHC experiments and CERN. By sharing development, this will reduce the overall effort required to build and maintain the experiment control systems. As such, the main aim of the Framework is to deliver a common set of software components, tools and guidelines that can be used by the four LHC experiments to build their control systems. Although commercial components are used wherever possible, further added value is obtained by customisation for HEP-specific applications. The supervisory layer of the Framework is based on the SCADA tool PVSS, which was selected after a detailed evaluation. This is integrated with the front-end layer via both OPC (OLE for Process Control), an industrial standard, and the CERN-developed DIM (Distributed Information Management System) protocol. Several components are already in production and being used by running fixed-target experiments at CERN as well as for th...

  5. A rigorous framework for interactive robot control

    NARCIS (Netherlands)

    Stramigioli, S; Fasse, ED; Willems, JC

    2002-01-01

    This paper presents a rigorous, analytical framework for interactive control methods such as stiffness and impedance control. This paper does not present a novel synthesis method for robot control design. Rather, it presents a proper framework to analyse controllers for robots whose purpose is to in

  6. Cancer Care and Control

    OpenAIRE

    Schneidman, Miriam; Jeffers, Joanne; Duncan, Kalina

    2015-01-01

    Worldwide, deaths from cancer exceed those caused by human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS), tuberculosis, and malaria combined. Seventy percent of deaths due to cancer occur in low-and middle-income countries, which are often poorly prepared to deal with the growing burden of chronic disease. Over a period of 18 months, the cancer care and control...

  7. A Framework for Healthcare Planning and Control

    NARCIS (Netherlands)

    Hans, Erwin W.; Houdenhoven, van Mark; Hulshof, Peter J.H.; Hall, Randolph

    2012-01-01

    Rising expenditures spur healthcare organizations to organize their processes more efficiently and effectively. Unfortunately, healthcare planning and control lags behind manufacturing planning and control. We analyze existing planning and control concepts or frameworks for healthcare operations man

  8. Cancer control in Bangladesh.

    Science.gov (United States)

    Hussain, Syed Akram; Sullivan, Richard

    2013-12-01

    Cancer is predicted to be an increasingly important cause of morbidity and mortality in Bangladesh in the next few decades. The estimated incidence of 12.7 million new cancer cases will rise to 21.4 million by 2030. More than two-thirds of the total expenditure on health is through out-of-pocket payments. According to the Bangladesh Bureau of Statistics, cancer is the sixth leading cause of death. International Agency for Research on Cancer has estimated cancer-related death rates in Bangladesh to be 7.5% in 2005 and 13% in 2030. The two leading causes are in males are lung and oral cancer and in females are breast cancer and cervical cancer. Bangladesh is now in severe shortage of radiation therapy machines, hospital bed, trained oncologists, medical radiation physicists and technologists. Bangladesh having different cancers associated with smoking and smokeless tobacco use, Human papilloma virus infection, Hepatitis B and C infection, Helicobacter Pylori infection, arsenic contaminated groundwater, availability of chemical carcinogens mainly formalin treated fruits, fish and vegetables at open market, tannery waste contaminated with chromium (which is used for poultry feed and fish feed preparation). A World Health Organization study revealed the annual cost of illnesses in Bangladesh attributable to tobacco usage is US$ 500 million and the total annual benefit from the tobacco sector is US$ 305 million as tax revenue. Bangladesh has developed a National Cancer Control Strategy and Action Plan with the aim of delivering a universal, quality-based and timely service. Cancer prevention through tobacco control, health promotion and vaccination program, cancer early detection program for oral cavity, breast and cervix has initiated. Cancer detection and diagnostic facilities will be made available at medical colleges and district- hospitals and establish a referral chain. National capacity development, more cancer research will allow Bangladesh to deal effectively

  9. Cancer control in Bangladesh.

    Science.gov (United States)

    Hussain, Syed Akram; Sullivan, Richard

    2013-12-01

    Cancer is predicted to be an increasingly important cause of morbidity and mortality in Bangladesh in the next few decades. The estimated incidence of 12.7 million new cancer cases will rise to 21.4 million by 2030. More than two-thirds of the total expenditure on health is through out-of-pocket payments. According to the Bangladesh Bureau of Statistics, cancer is the sixth leading cause of death. International Agency for Research on Cancer has estimated cancer-related death rates in Bangladesh to be 7.5% in 2005 and 13% in 2030. The two leading causes are in males are lung and oral cancer and in females are breast cancer and cervical cancer. Bangladesh is now in severe shortage of radiation therapy machines, hospital bed, trained oncologists, medical radiation physicists and technologists. Bangladesh having different cancers associated with smoking and smokeless tobacco use, Human papilloma virus infection, Hepatitis B and C infection, Helicobacter Pylori infection, arsenic contaminated groundwater, availability of chemical carcinogens mainly formalin treated fruits, fish and vegetables at open market, tannery waste contaminated with chromium (which is used for poultry feed and fish feed preparation). A World Health Organization study revealed the annual cost of illnesses in Bangladesh attributable to tobacco usage is US$ 500 million and the total annual benefit from the tobacco sector is US$ 305 million as tax revenue. Bangladesh has developed a National Cancer Control Strategy and Action Plan with the aim of delivering a universal, quality-based and timely service. Cancer prevention through tobacco control, health promotion and vaccination program, cancer early detection program for oral cavity, breast and cervix has initiated. Cancer detection and diagnostic facilities will be made available at medical colleges and district- hospitals and establish a referral chain. National capacity development, more cancer research will allow Bangladesh to deal effectively

  10. COSO internal control integrated framework 2013

    CERN Document Server

    American Institute of Certified Public Accountants

    2013-01-01

    Issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO), the 2013 Internal Control – Integrated Framework(Framework) is expected to help organizations design and implement internal control in light of many changes in business and operating environments since the issuance of the original Framework in 1992. The new Framework retains the core definition of internal control and the five components of internal control, and it continues to emphasize the importance of management judgment in designing, implementing, and conducting a system of internal control, and in assessing its effectiveness. It broadens the application of internal control in addressing operations and reporting objectives, and clarifies the requirements for determining what constitutes effective internal control.

  11. Adaptive Feedfoward Feedback Control Framework Project

    Data.gov (United States)

    National Aeronautics and Space Administration — An Adaptive Feedforward and Feedback Control (AFFC) Framework is proposed to suppress the aircraft's structural vibrations and to increase the resilience of the...

  12. An Access Control Framework for Reflective Middleware

    Institute of Scientific and Technical Information of China (English)

    Gang Huang; Lian-Shan Sun

    2008-01-01

    Reflective middleware opens up the implementation details of middleware platform and applications at runtime for improving the adaptability of middleware-based systems. However, such openness brings new challenges to access control of the middleware-based systems.Some users can access the system via reflective entities, which sometimes cannot be protected by access control mechanisms of traditional middleware. To deliver high adaptability securely, reflective middleware should be equipped with proper access control mechanisms for potential access control holes induced by reflection. One reason of integrating these mechanisms in reflective middleware is that one goal of reflective middleware is to equip applications with reflection capabilities as transparent as possible. This paper studies how to design a reflective J2EE middlewarePKUAS with access control in mind. At first, a computation model of reflective system is built to identify all possible access control points induced by reflection. Then a set of access control mechanisms, including the wrapper of MBeans and a hierarchy of Java class loaders, are equipped for controlling the identified access control points. These mechanisms together with J2EE access control mechanism form the access control framework for PKUAS. The paper evaluates the security and the performance overheads of the framework in quality and quantity.

  13. Models for local implementation of comprehensive cancer control: meeting local cancer control needs through community collaboration.

    Science.gov (United States)

    Behringer, Bruce; Lofton, Staci; Knight, Margaret L

    2010-12-01

    The comprehensive cancer control approach is used by state, tribes, tribal organizations, territorial and Pacific Island Jurisdiction cancer coalitions to spur local implementation of cancer plans to reduce the burden of cancer in jurisdictions across the country. There is a rich diversity of models and approaches to the development of relationships and scope of planning for cancer control activities between coalitions and advocates in local communities. The national comprehensive cancer control philosophy provides an operational framework while support from the Centers for Disease Control and Prevention enables coalitions to act as catalysts to bring local partners together to combat cancer in communities. This manuscript describes multiple characteristics of cancer coalitions and how they are organized. Two models of how coalitions and local partners collaborate are described. A case study method was used to identify how five different state and tribal coalitions use the two models to organize their collaborations with local communities that result in local implementation of cancer plan priorities. Conclusions support the use of multiple organizing models to ensure involvement of diverse interests and sensitivity to local cancer issues that encourages implementation of cancer control activities. PMID:20938731

  14. Interaction framework for loosely-coupled controllers

    DEFF Research Database (Denmark)

    Falsig, Simon

    2011-01-01

    of these are illustrated; for instance tightly-coupled structures and protocols and a lack of clear interfaces and documentation. A look is taken at some existing architectures for robot controllers, but as these describe widely varying concepts of the controller (ranging between hardware, software and data......-flow structures), and do not venture into the lower hardware levels, the Node-on-Chip architecture is presented for use in this project. This architecture describes the use of FPGA-based nodes that interface actuators and sensors in a robotic system to a common network, by employing the versatility...... of programmable logic for flexible interfacing. The terms used to describe the various core aspects of the Node-on-Chip architecture are fully defined and arranged into taxonomies, to help provide a consistent vocabulary for work in robotic controllers. The TosNet protocol, network and framework are presented...

  15. Cancer Control in Bangladesh

    OpenAIRE

    Hussain, Syed Akram; Sullivan, Richard

    2013-01-01

    Cancer is predicted to be an increasingly important cause of morbidity and mortality in Bangladesh in the next few decades. The estimated incidence of 12.7 million new cancer cases will rise to 21.4 million by 2030. More than two-thirds of the total expenditure on health is through out-of-pocket payments. According to the Bangladesh Bureau of Statistics, cancer is the sixth leading cause of death. International Agency for Research on Cancer has estimated cancer-related death rates in Banglade...

  16. Generic Model Predictive Control Framework for Advanced Driver Assistance Systems

    NARCIS (Netherlands)

    Wang, M.

    2014-01-01

    This thesis deals with a model predictive control framework for control design of Advanced Driver Assistance Systems, where car-following tasks are under control. The framework is applied to design several autonomous and cooperative controllers and to examine the controller properties at the microsc

  17. Software Framework for Controlling Unsupervised Scientific Instruments.

    Science.gov (United States)

    Schmid, Benjamin; Jahr, Wiebke; Weber, Michael; Huisken, Jan

    2016-01-01

    Science outreach and communication are gaining more and more importance for conveying the meaning of today's research to the general public. Public exhibitions of scientific instruments can provide hands-on experience with technical advances and their applications in the life sciences. The software of such devices, however, is oftentimes not appropriate for this purpose. In this study, we describe a software framework and the necessary computer configuration that is well suited for exposing a complex self-built and software-controlled instrument such as a microscope to laymen under limited supervision, e.g. in museums or schools. We identify several aspects that must be met by such software, and we describe a design that can simultaneously be used to control either (i) a fully functional instrument in a robust and fail-safe manner, (ii) an instrument that has low-cost or only partially working hardware attached for illustration purposes or (iii) a completely virtual instrument without hardware attached. We describe how to assess the educational success of such a device, how to monitor its operation and how to facilitate its maintenance. The introduced concepts are illustrated using our software to control eduSPIM, a fluorescent light sheet microscope that we are currently exhibiting in a technical museum. PMID:27570966

  18. The Assemble and Animate Control Framework for Modular Reconfigurable Robots

    DEFF Research Database (Denmark)

    Christensen, David Johan; Schultz, Ulrik Pagh; Moghadam, Mikael

    2011-01-01

    This paper describes the “Assemble and Animate” (ASE) control framework. The objective of ASE is to provide a flexible and extendable control framework, which facilitates rapid development and deployment of modular reconfigurable robots. ASE includes a simple event-driven application framework, a...... planetary contingency, adaptive locomotion, self-reconfiguration, and tangible behavior-based programming....

  19. [Cancer prevention and tobacco control].

    Science.gov (United States)

    Yang, Gonghuan

    2015-04-01

    The paper summarized briefly the evidences for tobacco use as a cause of cancer based on hundreds of epidemiologic and biomedical studies carried out over the past 50-60 years, as well as overviewed the carcinogens in tobacco products and mechanisms of neoplasm induction by tobacco products. So, tobacco control is the important measure for cancer prevention.

  20. Cooperative Control Method of Active and Semiactive Control: New Framework for Vibration Control

    OpenAIRE

    Kazuhiko Hiramoto

    2014-01-01

    A new control design framework for vibration control, the cooperative control of active and semiactive control, is proposed in the paper. In the cooperative control, a structural system having both of an actuator and a semiactive control device, for example, MR damper and so forth, is defined as the control object. In the proposed control approach, the higher control performance is aimed by the cooperative control between the active control with the actuator and the semiactive control with th...

  1. An adaptive online learning framework for practical breast cancer diagnosis

    Science.gov (United States)

    Chu, Tianshu; Wang, Jie; Chen, Jiayu

    2016-03-01

    This paper presents an adaptive online learning (OL) framework for supporting clinical breast cancer (BC) diagnosis. Unlike traditional data mining, which trains a particular model from a fixed set of medical data, our framework offers robust OL models that can be updated adaptively according to new data sequences and newly discovered features. As a result, our framework can naturally learn to perform BC diagnosis using experts' opinions on sequential patient cases with cumulative clinical measurements. The framework integrates both supervised learning (SL) models for BC risk assessment and reinforcement learning (RL) models for decision-making of clinical measurements. In other words, online SL and RL interact with one another, and under a doctor's supervision, push the patient's diagnosis further. Furthermore, our framework can quickly update relevant model parameters based on current diagnosis information during the training process. Additionally, it can build flexible fitted models by integrating different model structures and plugging in the corresponding parameters during the prediction (or decision-making) process. Even when the feature space is extended, it can initialize the corresponding parameters and extend the existing model structure without loss of the cumulative knowledge. We evaluate the OL framework on real datasets from BCSC and WBC, and demonstrate that our SL models achieve accurate BC risk assessment from sequential data and incremental features. We also verify that the well-trained RL models provide promising measurement suggestions.

  2. Modeling the Aneuploidy Control of Cancer

    Directory of Open Access Journals (Sweden)

    Wang Zhong

    2010-07-01

    Full Text Available Abstract Background Aneuploidy has long been recognized to be associated with cancer. A growing body of evidence suggests that tumorigenesis, the formation of new tumors, can be attributed to some extent to errors occurring at the mitotic checkpoint, a major cell cycle control mechanism that acts to prevent chromosome missegregation. However, so far no statistical model has been available quantify the role aneuploidy plays in determining cancer. Methods We develop a statistical model for testing the association between aneuploidy loci and cancer risk in a genome-wide association study. The model incorporates quantitative genetic principles into a mixture-model framework in which various genetic effects, including additive, dominant, imprinting, and their interactions, are estimated by implementing the EM algorithm. Results Under the new model, a series of hypotheses tests are formulated to explain the pattern of the genetic control of cancer through aneuploid loci. Simulation studies were performed to investigate the statistical behavior of the model. Conclusions The model will provide a tool for estimating the effects of genetic loci on aneuploidy abnormality in genome-wide studies of cancer cells.

  3. A Probabilistic Framework for Detection of Skin Cancer by Raman Spectra

    DEFF Research Database (Denmark)

    Sigurdsson, Sigurdur

    2003-01-01

    This Ph.D. thesis focuses on objective methods for diagnosing skin cancer from Raman spectra. A method for suppressing background noise and dimension reduction in Raman spectra is suggested. A robust Bayesian framework for training a neural network is proposed, including an overfit control...... and outlier framework. Finally a visualization scheme for extracting important features from the trained neural network classifier based on sensitivity analysis is defined. The performance on two types of skin cancer showed that 97.9% of basal cell carcinoma were identified correctly and 85.5% of malignant....... These identified important features are shown to originate from molecular structure changes in lipids and proteins. While the theme of this dissertation is skin cancer diagnosis from Raman spectra, the dimension reduction and the neural network classifier can be applied in general to other types of pattern...

  4. Counselling framework for moderate-penetrance cancer-susceptibility mutations.

    Science.gov (United States)

    Tung, Nadine; Domchek, Susan M; Stadler, Zsofia; Nathanson, Katherine L; Couch, Fergus; Garber, Judy E; Offit, Kenneth; Robson, Mark E

    2016-09-01

    The use of multigene panels for the assessment of cancer susceptibility is expanding rapidly in clinical practice, particularly in the USA, despite concerns regarding the uncertain clinical validity for some gene variants and the uncertain clinical utility of most multigene panels. So-called 'moderate-penetrance' gene mutations associated with cancer susceptibility are identified in approximately 2-5% of individuals referred for clinical testing; some of these mutations are potentially actionable. Nevertheless, the appropriate management of individuals harbouring such moderate-penetrance genetic variants is unclear. The cancer risks associated with mutations in moderate-penetrance genes are lower and different than those reported for high-penetrance gene mutations (such as mutations in BRCA1 and BRCA2, and those associated with Lynch syndrome). The extrapolation of guidelines for the management of individuals with high-penetrance variants of cancer-susceptibility genes to the clinical care of patients with moderate-penetrance gene mutations could result in substantial harm. Thus, we provide a framework for clinical decision-making pending the development of a sufficient evidence base to document the clinical utility of the interventions for individuals with inherited moderate-penetrance gene mutations associated with an increased risk of cancer. PMID:27296296

  5. Application framework for programmable network control

    NARCIS (Netherlands)

    R. Strijkers; M. Cristea; C. de Laat; R. Meijer

    2010-01-01

    We present a framework that enables application developers to create complex and application specific network services. The essence of our approach is to utilize programmable network elements to create a software representation of network elements in the application. We show that the typical pattern

  6. Application Framework for Programmable Network Control

    NARCIS (Netherlands)

    Strijkers, R.J.; Cristea, R.M.; Laat, C. de; Meijer, R.J.

    2011-01-01

    We present a framework that enables application developers to create complex and application specific network services. The essence of our approach is to utilize programmable network elements to create a software representation of network elements in the application. We show that the typical pattern

  7. Transaction-Based Building Controls Framework, Volume 1: Reference Guide

    Energy Technology Data Exchange (ETDEWEB)

    Somasundaram, Sriram; Pratt, Robert G.; Akyol, Bora A.; Fernandez, Nicholas; Foster, Nikolas AF; Katipamula, Srinivas; Mayhorn, Ebony T.; Somani, Abhishek; Steckley, Andrew C.; Taylor, Zachary T.

    2014-04-28

    This document proposes a framework concept to achieve the objectives of raising buildings’ efficiency and energy savings potential benefitting building owners and operators. We call it a transaction-based framework, wherein mutually-beneficial and cost-effective market-based transactions can be enabled between multiple players across different domains. Transaction-based building controls are one part of the transactional energy framework. While these controls realize benefits by enabling automatic, market-based intra-building efficiency optimizations, the transactional energy framework provides similar benefits using the same market -based structure, yet on a larger scale and beyond just buildings, to the society at large.

  8. Transaction-Based Building Controls Framework, Volume 1: Reference Guide

    Energy Technology Data Exchange (ETDEWEB)

    Somasundaram, Sriram [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Pratt, Robert G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Akyol, Bora A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fernandez, Nicholas [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Foster, Nikolas AF [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Katipamula, Srinivas [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Mayhorn, Ebony T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Somani, Abhishek [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Steckley, Andrew C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Taylor, Zachary T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-12-01

    This document proposes a framework concept to achieve the objectives of raising buildings’ efficiency and energy savings potential benefitting building owners and operators. We call it a transaction-based framework, wherein mutually-beneficial and cost-effective market-based transactions can be enabled between multiple players across different domains. Transaction-based building controls are one part of the transactional energy framework. While these controls realize benefits by enabling automatic, market-based intra-building efficiency optimizations, the transactional energy framework provides similar benefits using the same market -based structure, yet on a larger scale and beyond just buildings, to the society at large.

  9. Network Control Systems RTAI framework A Review

    OpenAIRE

    Bhatia, Deepika; Shrawankar, Urmila

    2013-01-01

    With the advancement in the automation industry, to perform complex remote operations is required. Advancements in the networking technology has led to the development of different architectures to implement control from a large distance. In various control applications of the modern industry, the agents, such as sensors, actuators, and controllers are basically geographically distributed. For efficient working of a control application, all of the agents have to exchange information through a...

  10. An optimal control framework for estimating autopilot safety margins

    NARCIS (Netherlands)

    Govindarjan, N.; De Visser, C.C.; Van Kampen, E.; Krishnakumar, K.; Barlow, J.; Stepanyan, V.

    2014-01-01

    This paper presents an optimal control framework to determine a collection of open-loop command signals that mathematically guarantees operation of an aircraft within certain prescribed state constraints. The framework is specifically applied to estimate margins for the reference command inputs of a

  11. SMC framework in motion control systems

    OpenAIRE

    Şabanoviç, Asif; Sabanovic, Asif

    2007-01-01

    Design of a motion control system should take into account both the unconstrained motion performed without interaction with environment or another system, and the constrained motion where the system is in contact with environment or has certain functional interactions with another system. In this paper control systems design approach, based on siding mode methods, that allows selection of control for generic tasks as trajectory and/or force tracking as well as for systems that require maintai...

  12. Spacecraft Attitude Control in Hamiltonian Framework

    DEFF Research Database (Denmark)

    Wisniewski, Rafal

    2000-01-01

    The objective of this paper is to give a design scheme for attitude control algorithms of a generic spacecraft. Along with the system model formulated in the Hamilton's canonical form the algorithm uses information about a required potential energy and a dissipative term. The control action...

  13. A Framework for Optimal Control Allocation with Structural Load Constraints

    Science.gov (United States)

    Frost, Susan A.; Taylor, Brian R.; Jutte, Christine V.; Burken, John J.; Trinh, Khanh V.; Bodson, Marc

    2010-01-01

    Conventional aircraft generally employ mixing algorithms or lookup tables to determine control surface deflections needed to achieve moments commanded by the flight control system. Control allocation is the problem of converting desired moments into control effector commands. Next generation aircraft may have many multipurpose, redundant control surfaces, adding considerable complexity to the control allocation problem. These issues can be addressed with optimal control allocation. Most optimal control allocation algorithms have control surface position and rate constraints. However, these constraints are insufficient to ensure that the aircraft's structural load limits will not be exceeded by commanded surface deflections. In this paper, a framework is proposed to enable a flight control system with optimal control allocation to incorporate real-time structural load feedback and structural load constraints. A proof of concept simulation that demonstrates the framework in a simulation of a generic transport aircraft is presented.

  14. IMPROVEMENTS IN THE CONTROL FRAMEWORKS: COSO AND COBIT

    OpenAIRE

    Oana Diana OPREA

    2014-01-01

    After the corporate scandals from the beginning of the 21st century, there was a general lack of confidence in the quality of the financial reporting. The Sarbanes-Oxley Act came to address this issue, by imposing rules that would prevent such scandals in the future. In order to help companies with the compliance, control frameworks have been issued. The framework of the Committee of Sponsoring Organisations of the Treadway Commission offers guidance in matters of internal controls, whereas t...

  15. An optimal control framework for estimating autopilot safety margins

    OpenAIRE

    Govindarjan, N.; De Visser, C.C.; van Kampen, E.; K Krishnakumar; Barlow, J.; Stepanyan, V.

    2014-01-01

    This paper presents an optimal control framework to determine a collection of open-loop command signals that mathematically guarantees operation of an aircraft within certain prescribed state constraints. The framework is specifically applied to estimate margins for the reference command inputs of aircraft autopilot systems, so that safe operation within a given flight envelope can be assured under appropriate control action. Flight envelope excursions are generally considered as precursors t...

  16. Adaptive Feedfoward Feedback Control Framework Project

    Data.gov (United States)

    National Aeronautics and Space Administration — A novel approach is proposed for the suppression of the aircraft's structural vibration to increase the resilience of the flight control law in the presence of the...

  17. A Bayesian framework for speech motor control

    OpenAIRE

    Patri, Jean-François; Diard, Julien; Perrier, Pascal; Schwartz, Jean-Luc

    2015-01-01

    The remarkable capacity of the speech motor system to adapt to various speech conditions is due to an excess of degrees of freedom, which enables producing similar acoustical properties with different sets of control strategies. To explain how the Central Nervous System selects one of the possible strategies, a common approach, in line with optimal motor control theories, is to model speech motor planning as the solution of an optimality problem based on cost functions. Despite the success of...

  18. A theoretical stochastic control framework for adapting radiotherapy to hypoxia

    Science.gov (United States)

    Saberian, Fatemeh; Ghate, Archis; Kim, Minsun

    2016-10-01

    Hypoxia, that is, insufficient oxygen partial pressure, is a known cause of reduced radiosensitivity in solid tumors, and especially in head-and-neck tumors. It is thus believed to adversely affect the outcome of fractionated radiotherapy. Oxygen partial pressure varies spatially and temporally over the treatment course and exhibits inter-patient and intra-tumor variation. Emerging advances in non-invasive functional imaging offer the future possibility of adapting radiotherapy plans to this uncertain spatiotemporal evolution of hypoxia over the treatment course. We study the potential benefits of such adaptive planning via a theoretical stochastic control framework using computer-simulated evolution of hypoxia on computer-generated test cases in head-and-neck cancer. The exact solution of the resulting control problem is computationally intractable. We develop an approximation algorithm, called certainty equivalent control, that calls for the solution of a sequence of convex programs over the treatment course; dose-volume constraints are handled using a simple constraint generation method. These convex programs are solved using an interior point algorithm with a logarithmic barrier via Newton’s method and backtracking line search. Convexity of various formulations in this paper is guaranteed by a sufficient condition on radiobiological tumor-response parameters. This condition is expected to hold for head-and-neck tumors and for other similarly responding tumors where the linear dose-response parameter is larger than the quadratic dose-response parameter. We perform numerical experiments on four test cases by using a first-order vector autoregressive process with exponential and rational-quadratic covariance functions from the spatiotemporal statistics literature to simulate the evolution of hypoxia. Our results suggest that dynamic planning could lead to a considerable improvement in the number of tumor cells remaining at the end of the treatment course

  19. Evidence supporting the conceptual framework of cancer chemoprevention in canines.

    Science.gov (United States)

    Kondratyuk, Tamara P; Adrian, Julie Ann Luiz; Wright, Brian; Park, Eun-Jung; van Breemen, Richard B; Morris, Kenneth R; Pezzuto, John M

    2016-01-01

    As with human beings, dogs suffer from the consequences of cancer. We investigated the potential of a formulation comprised of resveratrol, ellagic acid, genistein, curcumin and quercetin to modulate biomarkers indicative of disease prevention. Dog biscuits were evaluated for palatability and ability to deliver the chemopreventive agents. The extent of endogenous DNA damage in peripheral blood lymphocytes from dogs given the dietary supplement or placebo showed no change. However, H2O2-inducible DNA damage was significantly decreased after consumption of the supplement. The expression of 11 of 84 genes related to oxidative stress was altered. Hematological parameters remained in the reference range. The concept of chemoprevention for the explicit benefit of the canine is compelling since dogs are an important part of our culture. Our results establish a proof-of-principle and provide a framework for improving the health and well-being of "man's best friend". PMID:27216246

  20. The role of cancer registries in cancer control.

    Science.gov (United States)

    Parkin, Donald Maxwell

    2008-04-01

    Cancer control aims to reduce the incidence, morbidity, and mortality of cancer and to improve the quality of life of cancer patients through the systematic implementation of evidence-based interventions in prevention, early diagnosis, treatment, and palliative care. In the context of a national cancer control program (NCCP), a cancer surveillance program (CSP), built around a population-based cancer registry, is an essential element. Data on the size and evolution of the cancer burden in the population are essential to evaluation of the current situation, to setting objectives for cancer control, and defining priorities. Cancer data are essential in monitoring the progress of the implementation of an NCCP, as well as providing an evaluation of the many individual cancer control activities. In the context of an NCCP, the CSP should provide a focus of epidemiological expertise, not only for providing statistical data on incidence, mortality, stage distribution, treatment patterns, and survival but also for conducting studies into the important causes of cancer in the local situation, and for providing information about the prevalence of exposure to these factors in the population. Cancer surveillance via the population-based registry therefore plays a crucial role in formulating cancer control plans, as well as in monitoring their success. PMID:18463952

  1. Identifying Cancer Biomarkers Via Node Classification within a Mapreduce Framework

    Directory of Open Access Journals (Sweden)

    Taysir Hassan A. Soliman

    2015-12-01

    Full Text Available Big data are giving new research challenges in the life sciences domain because of their variety, volume, veracity, velocity, and value. Predicting gene biomarkers is one of the vital research issues in bioinformatics field, where microarray gene expression and network based methods can be used. These datasets suffer from the huge data voluminous, causing main memory problems. In this paper, a Random Committee Node Classifier algorithm (RCNC is proposed for identifying cancer biomarkers, which is based on microarray gene expression data and Protein-Protein Interaction (PPI data. Data are enriched from other public databases, such as IntACT1 and UniProt2 and Gene Ontology3 (GO. Cancer Biomarkers are identified when applied to different datasets with an accuracy rate an accuracy rate 99.16%, 99.96% precision, 99.24% recall, 99.16% F1-measure and 99.6 ROC. To speed up the performance, it is run within a MapReduce framework, where RCNC MapReduce algorithm is much faster than RCNC sequential algorithm when having large datasets.

  2. The Cancer Prevention and Control Research Network

    Directory of Open Access Journals (Sweden)

    Jeffrey R. Harris, MD, MPH, MBA

    2005-01-01

    Full Text Available The Cancer Prevention and Control Research Network is a national network recently established to focus on developing new interventions and disseminating and translating proven interventions into practice to reduce cancer burden and disparities, especially among minority and medically underserved populations. Jointly funded by the Centers for Disease Control and Prevention and the National Cancer Institute, the Cancer Prevention and Control Research Network consists of sites administered through Prevention Research Centers funded by the Centers for Disease Control and Prevention. The five sites are located in Kentucky, Massachusetts, South Carolina, Texas, Washington State, and West Virginia. The Cancer Prevention and Control Research Network’s intervention areas include primary prevention of cancer through healthy eating, physical activity, sun avoidance, tobacco control, and early detection of cancer through screening. The Cancer Prevention and Control Research Network uses the methods of community-based participatory research and seeks to build on the cancer-relevant systematic reviews of the Guide to Community Preventive Services. Initial foci for the Cancer Prevention and Control Research Network’s research work groups include projects to increase screening for breast, cervical, and colorectal cancers; to promote informed decision making for prostate cancer screening; and to validate educational materials developed for low-literacy populations.

  3. Distributed Software Development Modelling and Control Framework

    Directory of Open Access Journals (Sweden)

    Yi Feng

    2012-10-01

    Full Text Available With the rapid progress of internet technology, more and more software projects adopt e-development tofacilitate the software development process in a world-wide context. However, distributed softwaredevelopment activity itself is a complex orchestration. It involves many people working together without thebarrier of time and space difference. Therefore, how to efficiently monitor and control software edevelopmentin a global perspective becomes an important issue for any internet-based softwaredevelopment project. In this paper, we present a novel approach to tackle this crucial issue by means ofcontrolling e-development process, collaborative task progress and communication quality. Meanwhile, wealso present our e-development supporting environment prototype: Caribou, to demonstrate the viability ofour approach.

  4. A framework for health care planning and control

    OpenAIRE

    Hans, Erwin W.; Houdenhoven, van, M.; Hulshof, Peter J.H.

    2011-01-01

    Rising expenditures spur health care organizations to organize their processes more efficiently and effectively. Unfortunately, health care planning and control lags far behind manufacturing planning and control. Successful manufacturing planning and control concepts can not be directly copied, because of the unique nature of health care delivery. We analyze existing planning and control concepts or frameworks for health care operations management, and find that they do not properly address v...

  5. IMPROVEMENTS IN THE CONTROL FRAMEWORKS: COSO AND COBIT

    Directory of Open Access Journals (Sweden)

    Oana Diana OPREA

    2014-06-01

    Full Text Available After the corporate scandals from the beginning of the 21st century, there was a general lack of confidence in the quality of the financial reporting. The Sarbanes-Oxley Act came to address this issue, by imposing rules that would prevent such scandals in the future. In order to help companies with the compliance, control frameworks have been issued. The framework of the Committee of Sponsoring Organisations of the Treadway Commission offers guidance in matters of internal controls, whereas the Control Objectives for Information and related Technology focus on IT controls. The present paper intends to critically address the changes in the COSO and COBIT framework, that took place during 2012 and 2013.

  6. Applying the CobiT Control Framework to Spreadsheet Developments

    CERN Document Server

    Butler, Raymond J

    2008-01-01

    One of the problems reported by researchers and auditors in the field of spreadsheet risks is that of getting and keeping managements attention to the problem. Since 1996, the Information Systems Audit & Control Foundation and the IT Governance Institute have published CobiT which brings mainstream IT control issues into the corporate governance arena. This paper illustrates how spreadsheet risk and control issues can be mapped onto the CobiT framework and thus brought to managers attention in a familiar format.

  7. Applying the CobiT Control Framework to Spreadsheet Developments

    OpenAIRE

    Butler, Raymond J.

    2008-01-01

    One of the problems reported by researchers and auditors in the field of spreadsheet risks is that of getting and keeping managements attention to the problem. Since 1996, the Information Systems Audit & Control Foundation and the IT Governance Institute have published CobiT which brings mainstream IT control issues into the corporate governance arena. This paper illustrates how spreadsheet risk and control issues can be mapped onto the CobiT framework and thus brought to managers attention i...

  8. AFECS. Multi-Agent Framework for Experiment Control Systems

    Energy Technology Data Exchange (ETDEWEB)

    Vardan Gyurjyan; David Abbott; William Heyes; Edward Jastrzembski; Carl Timmer; Elliott Wolin

    2008-01-23

    AFECS is a pure Java based software framework for designing and implementing distributed control systems. AFECS creates a control system environment as a collection of software agents behaving as finite state machines. These agents can represent real entities, such as hardware devices, software tasks, or control subsystems. A special control oriented ontology language (COOL), based on RDFS (Resource Definition Framework Schema) is provided for control system description as well as for agent communication. AFECS agents can be distributed over a variety of platforms. Agents communicate with their associated physical components using range of communication protocols, including tcl-DP, cMsg (publish-subscribe communication system developed at Jefferson Lab), SNMP (simple network management protocol), EPICS channel access protocol and JDBC.

  9. AFECS. multi-agent framework for experiment control systems

    Energy Technology Data Exchange (ETDEWEB)

    Gyurjyan, V; Abbott, D; Heyes, G; Jastrzembski, E; Timmer, C; Wolin, E [Jefferson Lab, 12000 Jefferson Ave. MS-12B3, Newport News, VA 23606 (United States)], E-mail: gurjyan@jlab.org

    2008-07-01

    AFECS is a pure Java based software framework for designing and implementing distributed control systems. AFECS creates a control system environment as a collection of software agents behaving as finite state machines. These agents can represent real entities, such as hardware devices, software tasks, or control subsystems. A special control oriented ontology language (COOL), based on RDFS (Resource Definition Framework Schema) is provided for control system description as well as for agent communication. AFECS agents can be distributed over a variety of platforms. Agents communicate with their associated physical components using range of communication protocols, including tcl-DP, cMsg (publish-subscribe communication system developed at Jefferson Lab), SNMP (simple network management protocol), EPICS channel access protocol and JDBC.

  10. A framework for plot control in interactive story systems

    Energy Technology Data Exchange (ETDEWEB)

    Sgouros, N.M.; Papakonstantinou, G.; Tsanakas, P. [National Technical Univ. of Athens, Zographou Campus (Greece)

    1996-12-31

    This paper presents a framework for plot control in interactive story systems. In this framework, the user takes the place of the main character of the story, the protagonist. The rest of the cast consists of discrete characters, each playing a specific role in the story. A separate module in this system, the plot manager, controls the behavior of the cast and specifies what the protagonist can do. The story plot is dynamically shaped by the interference between cast members and their social interactions. The system accepts as input a story map which provides the main metaphor for organizing the plot and localizes the interaction of the protagonist with the rest of the cast. We are implementing this framework in PEGASUS, an interactive travel story environment for Greek mythology.

  11. DARC: Next generation decentralized control framework for robot applications

    DEFF Research Database (Denmark)

    Kjærgaard, Morten; Andersen, Nils Axel; Ravn, Ole

    2013-01-01

    This paper presents DARC, a next generation control framework for robot applications. It is designed to be equally powerful in prototyping research projects and for building serious commercial robots running on low powered embedded hardware, thus closing the gab between research and industry...

  12. A Unified Pseudospectral Framework for Nonlinear Controller and Observer Design

    OpenAIRE

    Gong, Qi; Ross, I. Michael; Kang, Wei

    2007-01-01

    Proceedings of the 2007 American Control Conference Marriott Marquis Hotel at Times Square New York City, USA, July 11-13, 2007 As a result of significant progress in pseudospectral methods for real-time dynamic optimization, it has become apparent in recent years that it is possible to present a unified framework for both controller and observer design. In this paper, we present such an approach for nonlinear systems. The method can be applied to a wide variety of nonlinear systems....

  13. A Robust Control Design Framework for Substructure Models

    Science.gov (United States)

    Lim, Kyong B.

    1994-01-01

    A framework for designing control systems directly from substructure models and uncertainties is proposed. The technique is based on combining a set of substructure robust control problems by an interface stiffness matrix which appears as a constant gain feedback. Variations of uncertainties in the interface stiffness are treated as a parametric uncertainty. It is shown that multivariable robust control can be applied to generate centralized or decentralized controllers that guarantee performance with respect to uncertainties in the interface stiffness, reduced component modes and external disturbances. The technique is particularly suited for large, complex, and weakly coupled flexible structures.

  14. Radiotherapy forgynecologic cancer innonagenarian patients:a framework fornew paradigms

    Institute of Scientific and Technical Information of China (English)

    BenoteMry; AlexisVallard; SophieEspenel; GuillaumeMoriceau; OlivierCollard; ClaireBosacki; JeanPhilippeJacquin; GuydeLaroche; PierreFournel; CyrusChargari; Nicolas Magn; SylvieMengueNdong; JeanBaptisteGuy; AviAssouline; AlexanderTFalk; AnasValeille; JaneChloTrone; RomainRivoirard; PierreAuberdiac

    2016-01-01

    No consensus exists regarding the role of radiotherapy in the management of gynecologic cancer in nonagenar‑ian patients. We retrospectively reviewed the outcomes of 19 consecutive nonagenarian patients with gynecologic cancer (6 endometrial cancers, 6 cervical cancers, 4 vulvar cancers, and 3 vaginal cancers) who were treated with radiotherapy. Radiotherapy was performed mainly in a palliative setting (n=12; 63.2%), with a median dose of 45Gy (range, 6–76Gy). Infrequent major acute or late toxicities were reported. Among 19 patients, 9 (47.4%) experienced tumor progression, 5 (26.3%) experienced complete response, 2 (10.5%) experienced stable disease and/or partial response. At last follow‑up, 12 patients (63.2%) had died; most deaths (n=9) occurred because of the cancer. These results suggest that radiotherapy is feasible in the treatment of nonagenarian patients with gynecologic cancer.

  15. Robust and optimal control a two-port framework approach

    CERN Document Server

    Tsai, Mi-Ching

    2014-01-01

    A Two-port Framework for Robust and Optimal Control introduces an alternative approach to robust and optimal controller synthesis procedures for linear, time-invariant systems, based on the two-port system widespread in electrical engineering. The novel use of the two-port system in this context allows straightforward engineering-oriented solution-finding procedures to be developed, requiring no mathematics beyond linear algebra. A chain-scattering description provides a unified framework for constructing the stabilizing controller set and for synthesizing H2 optimal and H∞ sub-optimal controllers. Simple yet illustrative examples explain each step. A Two-port Framework for Robust and Optimal Control  features: ·         a hands-on, tutorial-style presentation giving the reader the opportunity to repeat the designs presented and easily to modify them for their own programs; ·         an abundance of examples illustrating the most important steps in robust and optimal design; and ·   �...

  16. Nutrition-Related Cancer Prevention Cognitions and Behavioral Intentions: Testing the Risk Perception Attitude Framework

    Science.gov (United States)

    Sullivan, Helen W.; Beckjord, Ellen Burke; Finney Rutten, Lila J.; Hesse, Bradford W.

    2008-01-01

    This study tested whether the risk perception attitude framework predicted nutrition-related cancer prevention cognitions and behavioral intentions. Data from the 2003 Health Information National Trends Survey were analyzed to assess respondents' reported likelihood of developing cancer (risk) and perceptions of whether they could lower their…

  17. IEPLC Framework, Automated Communication in a Heterogeneous Control System Environment

    CERN Document Server

    Locci, F

    2014-01-01

    In CERN accelerators control system several components are essential such as: Programmable Logic Controller (PLC), PCI Extensions for Instrumentation (PXI), and other micro-controller families. Together with their weaknesses and their strength points they typically present custom communication protocols and it is therefore difficult to federate them into the control system using a single communication strategy. Furthermore this dependency to the physical device interfaces and protocols makes most of the code not reusable and the replacement of old technology a difficult problem. The purpose of IEPLC ([1]) is to mitigate the communication issues given by this heterogeneity; it proposes a framework to define communication interfaces in a hardware independent manner. In addition it automatically generates all the resources needed on master side (typically represented by a FEC: Front-End Computer) and slave side (typically represented by the controller) to implement a common and generic Ethernet communication. Th...

  18. Androgen Control in Prostate Cancer.

    Science.gov (United States)

    Pelekanou, Vasiliki; Castanas, Elias

    2016-10-01

    Research on prostate cancer has extensively advanced in the past decade, through an improved understanding for its genetic basis and risk-stratification. Molecular classification of prostate cancer into distinct subtypes and the recognition of new histologic entities promise the development of tailored-made management strategies of patients. Nowadays, various alternatives are available for clinical management of localized disease ranging from observation alone through radical prostatectomy. In patients with castration-resistant prostate cancer, the approval of new drugs for the management of metastatic disease has offered promising results improving the survival of these patients. In this context, androgen receptors (AR) remain at the epicenter of prostate cancer research holding a prominent role in the biology and therapeutic regimens of prostate cancer. As many of castration-resistant tumors retain hormone-responsiveness, AR is a clinical relevant, druggable target. However, AR paradoxically remains neglected as a prostate cancer biomarker. The great advancements in prostate cancer preclinical and clinical research, imply further improvement in clinical and translational data, for patient selection and treatment optimization. For a precision medicine-guided clinical management of prostate cancer, AR evaluation has to be implemented in companion and complementary diagnostics, as discussed here. J. Cell. Biochem. 117: 2224-2234, 2016. © 2016 Wiley Periodicals, Inc. PMID:27104784

  19. Access Request Trustworthiness in Weighted Access Control Framework

    Institute of Scientific and Technical Information of China (English)

    WANG Lun-wei; LIAO Xiang-ke; WANG Huai-min

    2005-01-01

    Weighted factor is given to access control policies to express the importance of policy and its effect on access control decision. According to this weighted access control framework, a trustworthiness model for access request is also given. In this model, we give the measure of trustworthiness factor to access request, by using some idea of uncertainty reasoning of expert system, present and prove the parallel propagation formula of request trustworthiness factor among multiple policies, and get the final trustworthiness factor to decide whether authorizing. In this model, authorization decision is given according to the calculation of request trustworthiness factor, which is more understandable, more suitable for real requirement and more powerful for security enhancement than traditional methods. Meanwhile the finer access control granularity is another advantage.

  20. Understanding Cancer Prevention, Detection, Treatment, Control

    Science.gov (United States)

    ... Home Current Issue Past Issues Special Section Understanding Cancer Prevention, Detection, Treatment, Control Past Issues / Spring 2007 Table ... 2004 than in 2003. Today's continuing progress against cancer is the result of enhanced prevention strategies, earlier detection, and better treatment — much of ...

  1. Peto's paradox and the hallmarks of cancer: constructing an evolutionary framework for understanding the incidence of cancer.

    Science.gov (United States)

    Nunney, L; Muir, B

    2015-07-19

    An evolutionary perspective can help unify disparate observations and make testable predictions. We consider an evolutionary model in relation to two mechanistic frameworks of cancer biology: multistage carcinogenesis and the hallmarks of cancer. The multistage model predicts that cancer risk increases with body size and longevity; however, this is not observed across species (Peto's paradox), but the paradox is resolved by invoking the evolution of additional genetic mechanisms to suppress cancer in large, long-lived species. It is when cancer cells overcome these defence mechanisms that they exhibit the hallmarks of cancer, driving the ongoing evolution of these defences, which in turn is expected to create the differences observed in the genetics of cancer across species and tissues. To illustrate the utility of an evolutionary model we examined some recently published data linking stem-cell divisions and cancer incidence across a range of tissues and show why the original analysis was faulty, and demonstrate that the data are consistent with a multistage model varying from three to seven mutational hits across different tissues. Finally, we demonstrate how an evolutionary model can both define patterns of inherited (familial) cancer and explain the prevalence of cancer in post-reproductive years, including the dominance of epithelial cancers.

  2. Analysis Of Cancer Omics Data In A Semantic Web Framework

    CERN Document Server

    Holford, Matt; Cheung, Kei; Krauthammer, Michael

    2010-01-01

    Our work concerns the elucidation of the cancer (epi)genome, transcriptome and proteome to better understand the complex interplay between a cancer cell's molecular state and its response to anti-cancer therapy. To study the problem, we have previously focused on data warehousing technologies and statistical data integration. In this paper, we present recent work on extending our analytical capabilities using Semantic Web technology. A key new component presented here is a SPARQL endpoint to our existing data warehouse. This endpoint allows the merging of observed quantitative data with existing data from semantic knowledge sources such as Gene Ontology (GO). We show how such variegated quantitative and functional data can be integrated and accessed in a universal manner using Semantic Web tools. We also demonstrate how Description Logic (DL) reasoning can be used to infer previously unstated conclusions from existing knowledge bases. As proof of concept, we illustrate the ability of our setup to answer compl...

  3. ARC Control Tower: A flexible generic distributed job management framework

    Science.gov (United States)

    Nilsen, J. K.; Cameron, D.; Filipčič, A.

    2015-12-01

    While current grid middleware implementations are quite advanced in terms of connecting jobs to resources, their client tools are generally quite minimal and features for managing large sets of jobs are left to the user to implement. The ARC Control Tower (aCT) is a very flexible job management framework that can be run on anything from a single users laptop to a multi-server distributed setup. aCT was originally designed to enable ATLAS jobs to be submitted to the ARC CE. However, with the recent redesign of aCT where the ATLAS specific elements are clearly separated from the ARC job management parts, the control tower can now easily be reused as a flexible generic distributed job manager for other communities. This paper will give a detailed explanation how aCT works as a job management framework and go through the steps needed to create a simple job manager using aCT and show that it can easily manage thousands of jobs.

  4. A Framework for Nonlinear Model Predictive Control in JModelica.org

    OpenAIRE

    Axelsson, Magdalena; Magnusson, Fredrik; Henningsson, Toivo

    2015-01-01

    Nonlinear Model Predictive Control (NMPC) is a control strategy based on repeatedly solving an optimal control problem. In this paper we present a new MPC framework for the JModelica.org platform, developed specifically for use in NMPC schemes. The new framework utilizes the fact that the optimal control problem to be solved does not change between solutions, thus decreasing the computation time needed to solve it. The new framework is compared to the old optimization framework in JModelica.o...

  5. A practical receding horizon control framework for path planning and control of autonomous vtol vehicles

    Science.gov (United States)

    Liu, C.; Chen, W.-H.

    2013-12-01

    This paper describes an integrated path planning and tracking control framework for autonomous vertical-take-off-and-landing (VTOL) vehicles, particularly quadrotors. The path planning adopts a receding horizon strategy to repeatedly plan a local trajectory that satisfies both the vehicle dynamics and obstacle-free requirement. A tracking controller is then designed to track the planned path. The differential flatness property of the quadrotor is exploited in both path planner and tracking controller designs. The proposed framework is verified by real-time simulations incorporating online optimization.

  6. TP-model transformation-based-control design frameworks

    CERN Document Server

    Baranyi, Péter

    2016-01-01

    This book covers new aspects and frameworks of control, design, and optimization based on the TP model transformation and its various extensions. The author outlines the three main steps of polytopic and LMI based control design: 1) development of the qLPV state-space model, 2) generation of the polytopic model; and 3) application of LMI to derive controller and observer. He goes on to describe why literature has extensively studied LMI design, but has not focused much on the second step, in part because the generation and manipulation of the polytopic form was not tractable in many cases. The author then shows how the TP model transformation facilitates this second step and hence reveals new directions, leading to powerful design procedures and the formulation of new questions. The chapters of this book, and the complex dynamical control tasks which they cover, are organized so as to present and analyze the beneficial aspect of the family of approaches (control, design, and optimization). Additionally, the b...

  7. Framework for controlling infection through isolation precautions in Japan.

    Science.gov (United States)

    Kawakami, Kazumi; Misao, Hanako

    2014-03-01

    In Japan, nurses certified in infection control face organizational and structural challenges to the implementation of the recommended isolation precautions. In this study, we developed a conceptual framework for the problem-solving process of certified nurses in infection control when implementing appropriate isolation-precaution measures. We conducted a qualitative, descriptive study using directed content analysis. Semistructured interviews were conducted with 40 nurses who had over five years' experience in infection control. Factors assessing the risk of infection in patients were identified, including microorganism characteristics, patient characteristics, and risk of infection to the entire unit. The nurses also assessed the risk of infection in institutions from the following perspectives: organizational culture, infection control system, human resources, environment surrounding the facility, ethical issues, and external factors. Individual characteristics, such as attributes, knowledge, expertise, and job function, were identified as major influencing factors in the problem-solving process. These findings could be useful for newly-certified nurses in infection control and provide recommendations on implementing isolation-precaution measures. PMID:24635895

  8. On properties of modeling control software for embedded control applications with CSP/CT framework

    NARCIS (Netherlands)

    Jovanovic, Dusko S.; Hilderink, Gerald H.; Broenink, Jan F.; Karelse, F.

    2003-01-01

    This PROGRESS project (TES.5224) traces a design framework for implementing embedded real-time software for control applications by exploiting its natural concurrency. The paper illustrates the stage of yielded automation in the process of structuring complex control software architectures, modeling

  9. Personalized in vitro cancer models to predict therapeutic response: Challenges and a framework for improvement.

    Science.gov (United States)

    Morgan, Molly M; Johnson, Brian P; Livingston, Megan K; Schuler, Linda A; Alarid, Elaine T; Sung, Kyung E; Beebe, David J

    2016-09-01

    Personalized cancer therapy focuses on characterizing the relevant phenotypes of the patient, as well as the patient's tumor, to predict the most effective cancer therapy. Historically, these methods have not proven predictive in regards to predicting therapeutic response. Emerging culture platforms are designed to better recapitulate the in vivo environment, thus, there is renewed interest in integrating patient samples into in vitro cancer models to assess therapeutic response. Successful examples of translating in vitro response to clinical relevance are limited due to issues with patient sample acquisition, variability and culture. We will review traditional and emerging in vitro models for personalized medicine, focusing on the technologies, microenvironmental components, and readouts utilized. We will then offer our perspective on how to apply a framework derived from toxicology and ecology towards designing improved personalized in vitro models of cancer. The framework serves as a tool for identifying optimal readouts and culture conditions, thus maximizing the information gained from each patient sample.

  10. Electronic patient self-assessment and management (SAM): A novel framework for cancer survivorship

    OpenAIRE

    Tighe Foss; Carroll Peter R; Cooperberg Matthew R; Basch Ethan; Salz Talya; Vickers Andrew J; Eastham James; Rosen Raymond C

    2010-01-01

    Abstract Background We propose a novel framework for management of cancer survivorship: electronic patient Self-Assessment and Management (SAM). SAM is a framework for transfer of information to and from patients in such a way as to increase both the patient's and the health care provider's understanding of the patient's progress, and to help ensure that patient care follows best practice. Methods Patients who participate in the SAM system are contacted by email at regular intervals and asked...

  11. A MULTISCALE, CELL-BASED FRAMEWORK FOR MODELING CANCER DEVELOPMENT

    Energy Technology Data Exchange (ETDEWEB)

    JIANG, YI [Los Alamos National Laboratory

    2007-01-16

    Cancer remains to be one of the leading causes of death due to diseases. We use a systems approach that combines mathematical modeling, numerical simulation, in vivo and in vitro experiments, to develop a predictive model that medical researchers can use to study and treat cancerous tumors. The multiscale, cell-based model includes intracellular regulations, cellular level dynamics and intercellular interactions, and extracellular level chemical dynamics. The intracellular level protein regulations and signaling pathways are described by Boolean networks. The cellular level growth and division dynamics, cellular adhesion and interaction with the extracellular matrix is described by a lattice Monte Carlo model (the Cellular Potts Model). The extracellular dynamics of the signaling molecules and metabolites are described by a system of reaction-diffusion equations. All three levels of the model are integrated through a hybrid parallel scheme into a high-performance simulation tool. The simulation results reproduce experimental data in both avasular tumors and tumor angiogenesis. By combining the model with experimental data to construct biologically accurate simulations of tumors and their vascular systems, this model will enable medical researchers to gain a deeper understanding of the cellular and molecular interactions associated with cancer progression and treatment.

  12. Hybrid Zeolitic Imidazolate Frameworks: Controlling Framework Porosity and Functionality by Mixed-Linker Synthesis

    KAUST Repository

    Thompson, Joshua A.

    2012-05-22

    Zeolitic imidazolate frameworks (ZIFs) are a subclass of nanoporous metal-organic frameworks (MOFs) that exhibit zeolite-like structural topologies and have interesting molecular recognition properties, such as molecular sieving and gate-opening effects associated with their pore apertures. The synthesis and characterization of hybrid ZIFs with mixed linkers in the framework are described in this work, producing materials with properties distinctly different from the parent frameworks (ZIF-8, ZIF-90, and ZIF-7). NMR spectroscopy is used to assess the relative amounts of the different linkers included in the frameworks, whereas nitrogen physisorption shows the evolution of the effective pore size distribution in materials resulting from the framework hybridization. X-ray diffraction shows these hybrid materials to be crystalline. In the case of ZIF-8-90 hybrids, the cubic space group of the parent frameworks is continuously maintained, whereas in the case of the ZIF-7-8 hybrids there is a transition from a cubic to a rhombohedral space group. Nitrogen physisorption data reveal that the hybrid materials exhibit substantial changes in gate-opening phenomena, either occurring at continuously tunable partial pressures of nitrogen (ZIF-8-90 hybrids) or loss of gate-opening effects to yield more rigid frameworks (ZIF-7-8 hybrids). With this synthetic approach, significant alterations in MOF properties may be realized to suit a desired separation or catalytic process. © 2012 American Chemical Society.

  13. Adaptive Fuzzy Consensus Clustering Framework for Clustering Analysis of Cancer Data.

    Science.gov (United States)

    Yu, Zhiwen; Chen, Hantao; You, Jane; Liu, Jiming; Wong, Hau-San; Han, Guoqiang; Li, Le

    2015-01-01

    Performing clustering analysis is one of the important research topics in cancer discovery using gene expression profiles, which is crucial in facilitating the successful diagnosis and treatment of cancer. While there are quite a number of research works which perform tumor clustering, few of them considers how to incorporate fuzzy theory together with an optimization process into a consensus clustering framework to improve the performance of clustering analysis. In this paper, we first propose a random double clustering based cluster ensemble framework (RDCCE) to perform tumor clustering based on gene expression data. Specifically, RDCCE generates a set of representative features using a randomly selected clustering algorithm in the ensemble, and then assigns samples to their corresponding clusters based on the grouping results. In addition, we also introduce the random double clustering based fuzzy cluster ensemble framework (RDCFCE), which is designed to improve the performance of RDCCE by integrating the newly proposed fuzzy extension model into the ensemble framework. RDCFCE adopts the normalized cut algorithm as the consensus function to summarize the fuzzy matrices generated by the fuzzy extension models, partition the consensus matrix, and obtain the final result. Finally, adaptive RDCFCE (A-RDCFCE) is proposed to optimize RDCFCE and improve the performance of RDCFCE further by adopting a self-evolutionary process (SEPP) for the parameter set. Experiments on real cancer gene expression profiles indicate that RDCFCE and A-RDCFCE works well on these data sets, and outperform most of the state-of-the-art tumor clustering algorithms. PMID:26357330

  14. Framework for hyperspectral image processing and quantification for cancer detection during animal tumor surgery

    Science.gov (United States)

    Lu, Guolan; Wang, Dongsheng; Qin, Xulei; Halig, Luma; Muller, Susan; Zhang, Hongzheng; Chen, Amy; Pogue, Brian W.; Chen, Zhuo Georgia; Fei, Baowei

    2015-12-01

    Hyperspectral imaging (HSI) is an imaging modality that holds strong potential for rapid cancer detection during image-guided surgery. But the data from HSI often needs to be processed appropriately in order to extract the maximum useful information that differentiates cancer from normal tissue. We proposed a framework for hyperspectral image processing and quantification, which includes a set of steps including image preprocessing, glare removal, feature extraction, and ultimately image classification. The framework has been tested on images from mice with head and neck cancer, using spectra from 450- to 900-nm wavelength. The image analysis computed Fourier coefficients, normalized reflectance, mean, and spectral derivatives for improved accuracy. The experimental results demonstrated the feasibility of the hyperspectral image processing and quantification framework for cancer detection during animal tumor surgery, in a challenging setting where sensitivity can be low due to a modest number of features present, but potential for fast image classification can be high. This HSI approach may have potential application in tumor margin assessment during image-guided surgery, where speed of assessment may be the dominant factor.

  15. Survivorship care planning in a comprehensive cancer center using an implementation framework.

    Science.gov (United States)

    Garcia, Sofia F; Kircher, Sheetal M; Oden, Megan; Veneruso, Aubri; McKoy, June M; Pearman, Timothy; Penedo, Frank J

    2016-05-01

    Cancer survivorship care plans (SCPs) have been recommended to improve clinical care and patient outcomes. Research is needed to establish their efficacy and identify best practices. Starting in 2015, centers accredited by the American College of Surgeons Commission on Cancer must deliver SCPs to patients completing primary cancer treatment with curative intent. We describe how we established routine SCP delivery at the Robert H Lurie Comprehensive Cancer Center in Chicago, Illinois, using the Quality Implementation Framework. We evaluated local practices, gathered clinician and patient stakeholder input, developed customized SCP templates within the electronic health record (EHR), and implemented 2 complementary delivery models. Clinician interviews (n = 41) and survey responses (n = 12), along with input from patients (n = 68) and a patient advisory board (n = 15), indicated support for SCPs and survivorship services. To promote feasible implementation and leverage existing workflows, we harmonized 2 SCP delivery models: integrated care within clinics where patients received treatment, and referral to a centralized survivorship clinic. We are implementing SCP delivery with prominent disease sites and will extend services to survivors of other cancers in the future. We developed four electronic disease-specific SCP templates for breast, colorectal, lung, and prostate cancers and a fifth, generic template that can be used for other malignancies. The templates reduced free-text clinician entry by auto-populating 20% of the fields from existing EHR data, and using drop-down menus for another 65%. Mean SCP completion time is 12 minutes (range, 10-15; n = 64). We designed our framework to facilitate ongoing evaluation of implementation and quality improvement. Funding/sponsorship Robert H Lurie Comprehensive Cancer Center, the Coleman Foundation, and the Lynn Sage Cancer Research Foundation. PMID:27258051

  16. The Development of a Framework for Target Diagnostic Centralized Control System (TDCCS) in ICF Experiments

    Institute of Scientific and Technical Information of China (English)

    ZHANG Chi; WANG Jian; YU Xiaoqi; YANG Dong

    2008-01-01

    A framework for target diagnostic centralized control system (TDCCS) in inertial confinement fusion (ICF) experiment has been developed. The developed framework is based on the common object request broker architecture (CORBA) standard and part of the concept from the ICFRoot (a framework based on ROOT for ICF experiments) framework design. This framework is of a component architecture, including a message bus, command executer, status processor, parser and proxy. To test the function of the framework, a simplified prototype of the TDCCS has been developed as well.

  17. The Development of a Framework for Target Diagnostic Centralized Control System (TDCCS) in ICF Experiments

    Science.gov (United States)

    Zhang, Chi; Wang, Jian; Yu, Xiaoqi; Yang, Dong

    2008-02-01

    A framework for target diagnostic centralized control system (TDCCS) in inertial confinement fusion (ICF) experiment has been developed. The developed framework is based on the common object request broker architecture (CORBA) standard and part of the concept from the ICFRoot (a framework based on ROOT for ICF experiments) framework design. This framework is of a component architecture, including a message bus, command executer, status processor, parser and proxy. To test the function of the framework, a simplified prototype of the TDCCS has been developed as well.

  18. Spatial Heterogeneity in Cancer Control Planning and Cancer Screening Behavior.

    Science.gov (United States)

    Mobley, Lee R; Kuo, Tzy-Mey; Urato, Matthew; Subramanian, Sujha; Watson, Lisa; Anselin, Luc

    2012-01-01

    Each state is autonomous in its comprehensive cancer control (CCC) program, and considerable heterogeneity exists in the program plans. However, researchers often focus on the concept of nationally representative data and pool observations across states using regression analysis to come up with average effects when interpreting results. Due to considerable state autonomy and heterogeneity in various dimensions-including culture, politics, historical precedent, regulatory environment, and CCC efforts-it is important to examine states separately and to use geographic analysis to translate findings in place and time. We used 100 percent population data for Medicare-insured persons aged 65 or older and examined predictors of breast cancer (BC) and colorectal cancer (CRC) screening from 2001-2005. Examining BC and CRC screening behavior separately in each state, we performed 100 multilevel regressions. We summarize the state-specific findings of racial disparities in screening for either cancer in a single bivariate map of the 50 states, producing a separate map for African American and for Hispanic disparities in each state relative to whites. The maps serve to spatially translate the voluminous regression findings regarding statistically significant disparities between whites and minorities in cancer screening within states. Qualitative comparisons can be made of the states' disparity environments or for a state against a national benchmark using the bivariate maps. We find that African Americans in Michigan and Hispanics in New Jersey are significantly more likely than whites to utilize CRC screening and that Hispanics in 6 states are significantly and persistently more likely to utilize mammography than whites. We stress the importance of spatial translation research for informing and evaluating CCC activities within states and over time. PMID:24944346

  19. Colon cancer controls versus population controls in case-control studies of occupational risk factors

    Directory of Open Access Journals (Sweden)

    Sabroe Svend

    2004-04-01

    Full Text Available Abstract Background Since updated population registers do not exist in many countries it is often difficult to sample valid population controls from the study base to a case-control study. Use of patient controls is an alternative option if the exposure experience under study for these patients are interchangeable with the experience for population controls. Patient controls may even be preferable from population controls under certain conditions. In this study we examine if colon cancer patients can serve as surrogates for proper population controls in case-control studies of occupational risk factors. Methods The study was conducted from 1995 to 1997. Incident colon cancer controls (N = 428 aged 35–69 years with a histological verified diagnosis and population controls (N = 583 were selected. Altogether 254 (59% of the colon cancer controls and 320 (55% of the population controls were interviewed about occupational, medical and life style conditions. Results No statistical significant difference for educational level, medical history or smoking status was seen between the two control groups. There was evidence of a higher alcohol intake, less frequent work as a farmer and less exposure to pesticides among colon cancer controls. Conclusions Use of colon cancer controls may provide valid exposure estimates in studies of many occupational risk factors for cancer, but not for studies on exposure related to farming.

  20. Electronic patient self-assessment and management (SAM: a novel framework for cancer survivorship

    Directory of Open Access Journals (Sweden)

    Tighe Foss

    2010-06-01

    Full Text Available Abstract Background We propose a novel framework for management of cancer survivorship: electronic patient Self-Assessment and Management (SAM. SAM is a framework for transfer of information to and from patients in such a way as to increase both the patient's and the health care provider's understanding of the patient's progress, and to help ensure that patient care follows best practice. Methods Patients who participate in the SAM system are contacted by email at regular intervals and asked to complete validated questionnaires online. Patient responses on these questionnaires are then analyzed in order to provide patients with real-time, online information about their progress and to provide them with tailored and standardized medical advice. Patient-level data from the questionnaires are ported in real time to the patient's health care provider to be uploaded to clinic notes. An initial version of SAM has been developed at Memorial Sloan-Kettering Cancer Center (MSKCC and the University of California, San Francisco (UCSF for aiding the clinical management of patients after surgery for prostate cancer. Results Pilot testing at MSKCC and UCSF suggests that implementation of SAM systems are feasible, with no major problems with compliance (> 70% response rate or security. Conclusion SAM is a conceptually simple framework for passing information to and from patients in such a way as to increase both the patient's and the health care provider's understanding of the patient's progress, and to help ensure that patient care follows best practice.

  1. Evaluating a Web-Based Educational Module on Oral Cancer Examination Based on a Behavioral Framework.

    Science.gov (United States)

    Wee, Alvin G; Zimmerman, Lani M; Pullen, Carol H; Allen, Carl M; Lambert, Paul M; Paskett, Electra D

    2016-03-01

    Patients at risk of developing oral and/or oropharyngeal cancer (OPC) are more likely to see primary care providers (PCPs) than a dentist. Many PCPs do not regularly perform oral cancer examination (OCE). The purpose of this study was to design a web-based educational program based on a behavioral framework to encourage PCPs to conduct OCE. PCPs were solicited to provide feedback on the program and to evaluate their short-term knowledge. The integrated behavioral model was used to design the program. Fifteen PCPs (five in each group: physicians, physician assistants, and nurse practitioners) reviewed the program and took a posttest: (1) index of knowledge of risk factors for oral cancer (RiskOC) and (2) index of knowledge of diagnostic procedures for oral cancer (DiagOC). Findings from the process evaluation were mainly positive, with comments on the length of the program comprising the ten negative comments. No significant difference among groups of PCPs (physicians, physician assistants, and nurse practitioners) was detected for DiagOC (p = 0.43) or RiskOC (p = 0.201). A program on OPC for PCPs should be less than 40 min. Postviewing knowledge outcomes were similar for all PCPs. The web-based program on OPC based on a behavioral framework could have similar short-term knowledge outcomes for all PCPs and may increase the number of PCPs performing OCEs. PMID:25572460

  2. Barriers to overcome for effective cancer control in Africa.

    Science.gov (United States)

    Harford, Joe B

    2015-08-01

    Cancer control in Africa is complicated due to large differences in cancer incidence between countries caused by differences in exposure to known risk factors. For example, substantial differences are seen when selected cancers in north Africa are compared with those in sub-Saharan Africa. In the future, population growth and demographic shifts are likely to have profound effects on the prevalence of cancer across the continent. Likewise, many factors outside of health care such as language differences, conflict, and poverty can affect cancer control efforts. Although cooperation in cancer control efforts is desirable, differences in cultural and geopolitical factors that characterise African countries and their populations, together with the sheer size of the continent, present unique challenges to effective cancer control. This Series paper discusses factors related to the size, diversity, and conditions within Africa that present barriers to optimal collaboration in cancer control efforts across the continent. PMID:26248846

  3. Metabolic Control Analysis under Uncertainty: Framework Development and Case Studies

    OpenAIRE

    Wang, Liqing; Birol, İnanç; Hatzimanikatis, Vassily

    2004-01-01

    Information about the enzyme kinetics in a metabolic network will enable understanding of the function of the network and quantitative prediction of the network responses to genetic and environmental perturbations. Despite recent advances in experimental techniques, such information is limited and existing experimental data show extensive variation and they are based on in vitro experiments. In this article, we present a computational framework based on the well-established (log)linear formal...

  4. Radon Control Activities for Lung Cancer Prevention in National Comprehensive Cancer Control Program Plans, 2005–2011

    OpenAIRE

    Antonio Neri, MD, MPH; Sherri L. Stewart, PhD; William Angell, MS

    2013-01-01

    Introduction Radon is the second leading cause of lung cancer among smokers and the leading cause among nonsmokers. The US Environmental Protection Agency recommends that every home be tested for radon. Comprehensive Cancer Control (CCC) programs develop cancer coalitions that coordinate funding and resources to focus on cancer activities that are recorded in cancer plans. Radon tests, remediation, and radon mitigation techniques are relatively inexpensive, but it is unclear whether coalition...

  5. Re-examining the levers of control-framework: from interactive controls towards "interactive transparency". Case Rautaruukki Oyj.

    OpenAIRE

    Tero, Joanna

    2009-01-01

    HELSINKI SCHOOL OF ECONOMICS (HSE) ABSTRACT Department of Accounting and Finance 3.9.2009 Joanna Tero RE-EXAMINING THE LEVERS OF CONTROL-FRAMEWORK: FROM INTERACTIVE CONTROL TOWARDS “INTERACTIVE TRANSPARENCY” Case Rautaruukki Oyj. Objectives of the study The objective of this study is to critically re-examine Simons’ (1995) levers of control-framework, which has been widely used in previous research, but received only limited attempts of fur...

  6. IT Project Management Control and the Control Objectives for IT and Related Technology (CobiT) Framework

    OpenAIRE

    Bernroider, Edward; Ivanov, Milen

    2011-01-01

    Motivated by scarce academic consideration of project management control frameworks, this article explores usage, value and structure of frameworks with a focus on the popular Control Objectives for IT and related Technology (CobiT) construct. We attempt to add to an empirically validated structure of internal control over IT project management by including CobiT's views on the intended domain of content. Results from the empirical survey indicate that the metrics suggested by Cob...

  7. Status of the Use of Large-Scale Corba-Distributed Software Framework for NIF Controls

    International Nuclear Information System (INIS)

    The Integrated Computer Control System (ICCS) for the National Ignition Facility (NIF) is based on a scalable software framework that will be distributed over some 750 Computers throughout the NIF. The framework provides templates and services at multiple levels of abstraction for the construction of software applications that communicate via CORBA (Common Object Request Broker Architecture). Object-oriented software design patterns are implemented as templates to be extended by application software. Developers extend the framework base classes to model the numerous physical control points. About 140 thousand software objects, each individually addressable through CORBA, will be active at full scale. Most of the objects have persistent state that is initialized at system start-up and stored in a database. Centralized server programs that implement events, alerts, reservations, message logging, data archive, name services, and process management provide additional framework services. A higher-level model-based, distributed shot automation framework also provides a flexible and scalable scripted framework for automatic sequencing of work-flow for control and monitoring of NIF shots. The ICCS software framework has allowed for efficient construction of a software system that supports a large number of distributed control points representing a complex control application. Status of the use of this framework during first experimental shot campaigns and initial commissioning and build-out of the laser facility is described

  8. Theoretical review and framework : The roles of controllers

    NARCIS (Netherlands)

    Rouwelaar, ten J.A. (Hans)

    2007-01-01

    In the last decades, the position of the business unit controller has grown in importance. This study gives a review of the research behind the two roles, which business unit-controllers can fulfill in business life: the support role and the control role. The support role is associated with involved

  9. Framework of Combined Adaptive and Non-adaptive Attitude Control System for a Helicopter Experimental System

    Institute of Scientific and Technical Information of China (English)

    Akira Inoue; Ming-Cong Deng

    2006-01-01

    This paper presents a framework of a combined adaptive and non-adaptive attitude control system for a helicopter experimental system. The design method is based on a combination of adaptive nonlinear control and non-adaptive nonlinear control. With regard to detailed attitude control system design, two schemes are shown for different application cases.

  10. A Multiobjective Optimization Framework for Stochastic Control of Complex Systems

    Energy Technology Data Exchange (ETDEWEB)

    Malikopoulos, Andreas [ORNL; Maroulas, Vasileios [ORNL; Xiong, Professor Jie [The University of Tennessee

    2015-01-01

    This paper addresses the problem of minimizing the long-run expected average cost of a complex system consisting of subsystems that interact with each other and the environment. We treat the stochastic control problem as a multiobjective optimization problem of the one-stage expected costs of the subsystems, and we show that the control policy yielding the Pareto optimal solution is an optimal control policy that minimizes the average cost criterion for the entire system. For practical situations with constraints consistent to those we study here, our results imply that the Pareto control policy may be of value in deriving online an optimal control policy in complex systems.

  11. On the variational framework employing optimal control for biochemical thermodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Moroz, Adam, E-mail: amoroz@dmu.ac.uk [Engineering Dep., Faculty of Technology, De Montfort University, Leicester (United Kingdom); Wimpenny, David Ian [Engineering Dep., Faculty of Technology, De Montfort University, Leicester (United Kingdom)

    2011-02-28

    Graphical abstract: The study presented in the paper shows that the nonlinear kinetic processes (like logistic kinetics) at the level of the biomolecular and biophysical phenomena can be effectively described in terms of the maximum energy dissipation principle and its variational formulation. The variational approach and the logistic dissipative kinetic. (A) The trajectories of extent variable {xi}*. d* - calculated Lagrange function (L) corresponding to extent variable trajectory d. (B) The plot of the logarithm of numerically calculated dissipative (thermodynamic) momentum p*. Research highlights: {yields} The variational outline for maximum energy dissipation principle for non-linear biochemical processes is discussed. {yields} The Lagrangians are built as a goal functions, having an energetical sense. {yields} The Hamiltonians, canonical equations and optimal solutions have been obtained. {yields} The maximum energy dissipation principle is interpreted as thermodynamic form of the least action principle. - Abstract: The maximum energy dissipation principle can be successfully applied to describe a range of basic nonlinear models. The application of the general variational framework has been illustrated for basic linear schemes. The study presented in the paper shows how the kinetic processes at this level of the biomolecular and biophysical phenomena can be effectively described in terms of the maximum energy dissipation principle and its variational formulation. On the basis of this approach, a range of Lagrangians was proposed for basic nonlinear dissipative kinetic models. The results of this study show that the framework is in agreement with nonlinear equilibrium thermodynamics.

  12. Control Framework for Dexterous Manipulation Using Dynamic Visual Servoing and Tactile Sensors’ Feedback

    Directory of Open Access Journals (Sweden)

    Carlos A. Jara

    2014-01-01

    Full Text Available Tactile sensors play an important role in robotics manipulation to perform dexterous and complex tasks. This paper presents a novel control framework to perform dexterous manipulation with multi-fingered robotic hands using feedback data from tactile and visual sensors. This control framework permits the definition of new visual controllers which allow the path tracking of the object motion taking into account both the dynamics model of the robot hand and the grasping force of the fingertips under a hybrid control scheme. In addition, the proposed general method employs optimal control to obtain the desired behaviour in the joint space of the fingers based on an indicated cost function which determines how the control effort is distributed over the joints of the robotic hand. Finally, authors show experimental verifications on a real robotic manipulation system for some of the controllers derived from the control framework.

  13. An agile planning and control framework for customer-order driven discrete parts manufacturing environments

    NARCIS (Netherlands)

    Assen, van M.F.; Hans, E.W.; Velde, van de S.L.

    2000-01-01

    In this paper, we present a planning and control framework for manufacture-to-order environments that enables and supports agile-based discrete parts manufacturing. The characteristic elements of our framework are that it is decentralized, logistics and business oriented, and that it recognizes that

  14. A systematic framework for design of process monitoring and control (PAT) systems for crystallization processes

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli Bin; Sin, Gürkan; Gernaey, Krist;

    2013-01-01

    A generic computer-aided framework for systematic design of a process monitoring and control system for crystallization processes has been developed to study various aspects of crystallization operations.The systematic design framework contains a generic crystallizer modelling toolbox, a tool for...

  15. Review of State Comprehensive Cancer Control Plans for Genomics Content

    OpenAIRE

    Robert C. Millikan, DVM, PhD; Tejinder Rakhra-Burris, MA; Erin Shaughnessy Zuiker, MPH; Debra E. Irwin, PhD, MSPH

    2005-01-01

    Introduction The goals of this study were to determine U.S. states with Comprehensive Cancer Control plans that include genomics in some capacity and to review successes with and barriers to implementation of genomics-related cancer control initiatives. Methods This study was conducted in two phases. Phase one included a content analysis of written state Comprehensive Cancer Control plans (n = 30) for terms related to genomics, or genomic components (n = 18). The second phase involved te...

  16. ASDEX Upgrade Discharge Control System—A real-time plasma control framework

    Energy Technology Data Exchange (ETDEWEB)

    Treutterer, W., E-mail: Wolfgang.Treutterer@ipp.mpg.de [Max-Planck-Institut für Plasmaphysik, EURATOM Association, Boltzmannstraße 2, 85748 Garching (Germany); Cole, R.; Lüddecke, K. [Unlimited Computer Systems GmbH, Iffeldorf (Germany); Neu, G.; Rapson, C.; Raupp, G.; Zasche, D.; Zehetbauer, T. [Max-Planck-Institut für Plasmaphysik, EURATOM Association, Boltzmannstraße 2, 85748 Garching (Germany)

    2014-03-15

    Highlights: • The ASDEX Upgrade Discharge Control System (DCS) is a comprehensive control system to conduct fusion experiments. • DCS supports real-time diagnostic integration, adaptable feedback schemes, actuator management and exception handling. • DCS offers workflow management, logging and archiving, self-monitoring and inter-process communication. • DCS is based on a distributed, modular software framework architecture designed for real-time operation. • DCS is composed of re-usable generic but highly customisable components. - Abstract: ASDEX Upgrade is a fusion experiment with a size and complexity to allow extrapolation of technical and physical conditions and requirements to devices like ITER and even beyond. In addressing advanced physics topics it makes extensive use of sophisticated real-time control methods. It comprises real-time diagnostic integration, dynamically adaptable multivariable feedback schemes, actuator management including load distribution schemes and a powerful monitoring and pulse supervision concept based on segment scheduling and exception handling. The Discharge Control System (DCS) supplies all this functionality on base of a modular software framework architecture designed for real-time operation. It provides system-wide services like workflow management, logging and archiving, self-monitoring and inter-process communication on Linux, VxWorks and Solaris operating systems. By default DCS supports distributed computing, and a communication layer allows multi-directional signal transfer and data-driven process synchronisation over shared memory as well as over a number of real-time networks. The entire system is built following the same common design concept combining a rich set of re-usable generic but highly customisable components with a configuration-driven component deployment method. We will give an overview on the architectural concepts as well as on the outstanding capabilities of DCS in the domains of inter

  17. ASDEX Upgrade Discharge Control System—A real-time plasma control framework

    International Nuclear Information System (INIS)

    Highlights: • The ASDEX Upgrade Discharge Control System (DCS) is a comprehensive control system to conduct fusion experiments. • DCS supports real-time diagnostic integration, adaptable feedback schemes, actuator management and exception handling. • DCS offers workflow management, logging and archiving, self-monitoring and inter-process communication. • DCS is based on a distributed, modular software framework architecture designed for real-time operation. • DCS is composed of re-usable generic but highly customisable components. - Abstract: ASDEX Upgrade is a fusion experiment with a size and complexity to allow extrapolation of technical and physical conditions and requirements to devices like ITER and even beyond. In addressing advanced physics topics it makes extensive use of sophisticated real-time control methods. It comprises real-time diagnostic integration, dynamically adaptable multivariable feedback schemes, actuator management including load distribution schemes and a powerful monitoring and pulse supervision concept based on segment scheduling and exception handling. The Discharge Control System (DCS) supplies all this functionality on base of a modular software framework architecture designed for real-time operation. It provides system-wide services like workflow management, logging and archiving, self-monitoring and inter-process communication on Linux, VxWorks and Solaris operating systems. By default DCS supports distributed computing, and a communication layer allows multi-directional signal transfer and data-driven process synchronisation over shared memory as well as over a number of real-time networks. The entire system is built following the same common design concept combining a rich set of re-usable generic but highly customisable components with a configuration-driven component deployment method. We will give an overview on the architectural concepts as well as on the outstanding capabilities of DCS in the domains of inter

  18. Post Modification of Metal-Organic Framework and Their Application In Cancer Theranostics

    Science.gov (United States)

    Lakkakula, Hima bindu

    The research proposal aims to demonstrate that Metal-Organic Frameworks (MOFs) are mainly used for cancer theranostics which is the combination of both diagnostic and therapeutic functions. The research will emphasis on synthesis of Fe- MOFs by solvothermal nucleation, crystallization, characterization by microscopy and spectroscopy and evaluation with different lattice parameters and its morphology. Nowadays MOFs are used for the novel drug delivery purposes. The current published Fe- MOFs research focus is on the cancer theranostics by Indian medicines which will be impregnated into the MOFs and which will evaluate bioavailability and the chemotherapeutic activity of the drug. Nanotechnology provides the target specificity without affecting the healthy tissues. Other research problems to be addressed are the relationship between metal connectivity and ligand-based luminescence, MOF stability in an aqueous environment and activating it at increased temperature serves as a crucial role. The merits of this research are to increase the surface area and pore size of the drug so that the therapeutic efficacy can be improved. Moreover, the stabilization of metal-organic frameworks can also be enhanced with high surface area.

  19. [Application of cohort study in cancer prevention and control].

    Science.gov (United States)

    Dai, Min; Bai, Yana; Pu, Hongquan; Cheng, Ning; Li, Haiyan; He, Jie

    2016-03-01

    Cancer control is a long-term work. Cancer research and intervention really need the support of cohort study. In the recent years, more and more cohort studies on cancer control were conducted in China along with the increased ability of scientific research in China. Since 2010, Cancer Hospital, Chinese Academy of Medical Sciences, collaborated with Lanzhou University and the Worker' s Hospital of Jinchuan Group Company Limited, have carried out a large-scale cohort study on cancer, which covered a population of more than 50 000 called " Jinchang cohort". Since 2012, a National Key Public Health Project, "cancer screening in urban China" , has been conducted in Jinchang, which strengthened the Jinchang cohort study. Based on the Jinchang cohort study, historical cohort study, cross-sectional study and prospective cohort study have been conducted, which would provide a lot of evidence for the cancer control in China.

  20. A Distributed Control Framework for Integrated Photovoltaic-Battery Based Islanded Microgrids

    DEFF Research Database (Denmark)

    Golsorkhi, Mohammad; Shafiee, Qobad; Lu, Dylan;

    2016-01-01

    This paper proposes a new cooperative control framework for coordination of energy storage units (ESUs), photovoltaic (PV) panels and controllable load units in singlephase low voltage microgrids (MGs). The control objectives are defined and acted upon using a two level structure; primary and sec...

  1. Fully probabilistic control design in an adaptive critic framework.

    Science.gov (United States)

    Herzallah, Randa; Kárný, Miroslav

    2011-12-01

    Optimal stochastic controller pushes the closed-loop behavior as close as possible to the desired one. The fully probabilistic design (FPD) uses probabilistic description of the desired closed loop and minimizes Kullback-Leibler divergence of the closed-loop description to the desired one. Practical exploitation of the fully probabilistic design control theory continues to be hindered by the computational complexities involved in numerically solving the associated stochastic dynamic programming problem; in particular, very hard multivariate integration and an approximate interpolation of the involved multivariate functions. This paper proposes a new fully probabilistic control algorithm that uses the adaptive critic methods to circumvent the need for explicitly evaluating the optimal value function, thereby dramatically reducing computational requirements. This is a main contribution of this paper. PMID:21752597

  2. Coupling DCS and MARTe: two real-time control frameworks in collaboration

    Energy Technology Data Exchange (ETDEWEB)

    Rapson, Christopher J., E-mail: chris.rapson@ipp.mpg.de [Max Planck Institute for Plasma Physics, Boltzmannstrasse 2, 85748 Garching (Germany); Carvalho, Pedro [Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa (Portugal); Lüddecke, Klaus; Neto, André C. [Unlimited Computer Systems GmbH, Seeshaupterstr. 15, 82393 Iffeldorf (Germany); Santos, Bruno [Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa (Portugal); Treutterer, Wolfgang [Max Planck Institute for Plasma Physics, Boltzmannstrasse 2, 85748 Garching (Germany); Winter, Axel [ITER Organization, Route de Vinon-sur-Verdon, 13115 St.-Paul-Lès-Durance (France); Zehetbauer, Thomas [Max Planck Institute for Plasma Physics, Boltzmannstrasse 2, 85748 Garching (Germany)

    2014-12-15

    Highlights: • Similarities and differences between DCS and MARTe. • Identifies the state-of-the-art in terms of software frameworks for fusion control. • Interfaces developed for realtime and non-realtime communication between DCS and MARTe. • An algorithm replicated in DCS and MARTe produces identical results and good performance. • The start of collaboration to develop a new framework for ITER PCS. - Abstract: Fusion experiments place high demands on real-time control systems. Within the fusion community two modern framework-based software architectures have emerged as powerful tools for developing algorithms for real-time control of complex systems while maintaining the flexibility required when operating a physics experiment. The two frameworks are known as DCS (Discharge Control System), from ASDEX Upgrade and MARTe (Multithreaded Application Real-Time executor), originally from JET. Based on the success of DCS and MARTe, ITER has chosen to develop a framework architecture for its Plasma Control System which will adopt major design concepts from both the existing frameworks. This paper describes a coupling of the two existing frameworks, which was undertaken to explore the degree of similarity and compliance between the concepts, and to extend their capabilities. DCS and MARTe operate in parallel with synchronised state machines and a common message logger. Configuration data is exchanged before the real-time phase. During the real-time phase, structured data is exchanged via shared memory and an existing DCS algorithm is replicated within MARTe. The coupling tests the flexibility and identifies the respective strengths of the two frameworks, providing a well-informed basis on which to move forward and design a new ITER real-time framework.

  3. Design and implementation of a standard framework for KSTAR control system

    International Nuclear Information System (INIS)

    Highlights: • We performed a standardized of control system in KSTAR. • EPICS based software framework is developed for the realization of various control systems. • The applicability of the framework is widened from a simple command dispatcher to the real time application. • Our framework supports the implementation of embedded IOC in FPGA board. - Abstract: Standardization of control system is an important issue in KSTAR which is organized with various heterogeneous systems. Diverse control systems in KSTAR have been adopting new application software since 2010. Development of this software was launched for easy implementation of a data acquisition system but it is extended to as a Standard Framework (SFW) of control system in KSTAR. It is composed with a single library, database, template, and descriptor files. The SFW based controller has common factors. It has non-blocking control command method with a thread. The internal sequence handler makes it can be synchronized with KSTAR experiment. It also has a ring buffer pool mechanism for streaming input data handling. Recently, there are two important functional improvements in the framework. Processor embedded FPGA was proposed as a standard hardware platform for specific application. These are also manipulated by the SFW based embedded application. This approach gives single board system an ability of low level distributed control under the EPICS environments. We also developed a real time monitoring system as a real time network inspection tool in 2012 campaign using the SFW

  4. A Generic Framework for Systematic Design of Process Monitoring and Control System for Crystallization Processes

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli Bin; Meisler, Kresten Troelstrup; Sin, Gürkan;

    2012-01-01

    A generic framework for systematic design of a process monitoring and control system for crystallization processes has been developed in order to obtain the desired end-product properties notably the crystal size distribution (CSD). The design framework contains a generic crystallizer modelling...... tool-box, a tool for design of operational policies as well as a tool for design of process monitoring and control systems. Through this framework, it is possible for a wide range of crystallization processes to generate the necessary problem-system specific model, the necessary operational policy...... and a Process Analytical Technology (PAT) system design including implementation of monitoring tools and control strategies in order to produce a desired product with its corresponding target properties. Application of the framework is highlighted through a case study involving the system potassium dihydrogen...

  5. Review of State Comprehensive Cancer Control Plans for Genomics Content

    Directory of Open Access Journals (Sweden)

    Robert C. Millikan, DVM, PhD

    2005-03-01

    Full Text Available Introduction The goals of this study were to determine U.S. states with Comprehensive Cancer Control plans that include genomics in some capacity and to review successes with and barriers to implementation of genomics-related cancer control initiatives. Methods This study was conducted in two phases. Phase one included a content analysis of written state Comprehensive Cancer Control plans (n = 30 for terms related to genomics, or “genomic components” (n = 18. The second phase involved telephone interviews with the Comprehensive Cancer Control plan coordinators in states with plans that contained genomic components (n = 16. The interview was designed to gather more detailed information about the genomics-related initiatives within the state’s Comprehensive Cancer Control plan and the successes with and barriers to plan implementation, as defined by each state. Results Eighteen of the 30 Comprehensive Cancer Control plans analyzed contained genomics components. We noted a large variability among these 18 plans in the types of genomics components included. Nine (56% of the 16 states interviewed had begun to implement the genomics components in their plan. Most states emphasized educating health care providers and the public about the role of genomics in cancer control. Many states consider awareness of family history to be an important aspect of their Comprehensive Cancer Control plan. Approximately 67% of states with family history components in their plans had begun to implement these goals. Virtually all states reported they would benefit from additional training in cancer genetics and general public health genomics. Conclusion The number of states incorporating genomics into their Comprehensive Cancer Control plans is increasing. Family history is a public health application of genomics that could be implemented more fully into Comprehensive Cancer Control plans.

  6. Reproductive Risk Factors for Breast Cancer: A Case Control Study

    OpenAIRE

    Meshram II; Hiwarkar PA; Kulkarni PN

    2009-01-01

    Background: Breast cancer is second most important cancer among Indian women. Although risk factors are not much prevalent as in western countries, incidence rate is increasing in India. The study was undertaken to study various risk factors associated with breast cancer. Methods: A hospital based group matched case control study was undertaken to identify risk factors. The study consisted of 105 hospitalized cases confirmed on histopathology and 210 group matched controls selected from urban...

  7. Risk factors for ovarian cancer: a case-control study.

    OpenAIRE

    Booth, M.; Beral, V; SMITH, P.

    1989-01-01

    A hospital-based case-control study of ovarian cancer was conducted in London and Oxford between October 1978 and February 1983. Menstrual characteristics, reproductive and contraceptive history and history of exposure to various environmental factors were compared between 235 women with histologically diagnosed epithelial ovarian cancer and 451 controls. High gravidity, hysterectomy, female sterilisation and oral contraceptive use were associated with a reduced risk of ovarian cancer. Infert...

  8. CANCER CONTROL AND POPULATION SCIENCES FAST STATS

    Science.gov (United States)

    Fast Stats links to tables, charts, and graphs of cancer statistics for all major cancer sites by age, sex, race, and geographic area. The statistics include incidence, mortality, prevalence, and the probability of developing or dying from cancer. A large set of statistics is ava...

  9. A framework for selecting suitable control technologies for nuclear power plant systems

    International Nuclear Information System (INIS)

    New concepts continue to emerge for controlling systems, subsystems, and components and for monitoring parameters, characteristics, and vital signs in nuclear power plants. The steady stream of new control theories and the evolving state of control software exacerbates the difficulty of selecting the most appropriate control technology for nuclear power plant systems. As plant control room operators increase their reliance on computerized systems, the integration of monitoring, diagnostic, and control functions into a uniform and understandable environment becomes imperative. A systematic framework for comparing and evaluating the overall usefulness of control techniques is needed. This paper describes nine factors that may be used to evaluate alternative control concepts. These factors relate to a control system's potential effectiveness within the context of the overall environment, including both human and machine components. Although not an in-depth study, this paper serves to outline an evaluation framework based on several measures of utility. 32 refs

  10. Analytical Framework to Evaluate Emission Control Systems for Marine Engines

    OpenAIRE

    Jayaram, Varalakshmi

    2010-01-01

    Emissions from marine diesel engines are mainly uncontrolled and affect regional air quality and health of people living near ports. Many emission control strategies are evolving to reduce these emissions and their impacts. This dissertation characterizes the effectiveness of new technologies for reducing NOx and PM2.5 emissions from a range of marine diesel engines. Researchers, regulators and policy makers require these characterizations to develop emission inventories and suitable mitigati...

  11. Robust access control framework for mobile cloud computing network

    OpenAIRE

    Li, F; Rahulamathavan, Y.; Conti, M.; Rajarajan, M.

    2015-01-01

    Unified communications has enabled seamless data sharing between multiple devices running on various platforms. Traditionally, organizations use local servers to store data and employees access the data using desktops with predefined security policies. In the era of unified communications, employees exploit the advantages of smart devices and 4G wireless technology to access the data from anywhere and anytime. Security protocols such as access control designed for traditional setup are not su...

  12. Ownership structure, sharing of control and legal framework. International evidence

    OpenAIRE

    López de Foronda Pérez, Óscar; López Iturriaga, Félix Javier; Santamaría Mariscal, Marcos

    2007-01-01

    Analizamos la relación entre estructura del capital, estructura de la propiedad, y gobierno corporativo para una muestra de 1.216 empresas de 15 países europeos. Nuestros resultados recojen dos conflictos de intereses diferentes y muestran el papel diferencial jugado por los mecanismos de control corporativo dependiendo del ambiente legal e institucional. We analyze the relation between capital structure, ownership structure, and corporate value for a sample of 1,216 firms from 15 Europea...

  13. Legislative and regulatory framework for vector control1

    OpenAIRE

    2013-01-01

    This review aims to shed light on the respective responsibilities and competences of the country’s different institutional levels by examining the statutory texts: international health regulations; European directives; Community decisions; the French Public Health Code, General Code for Local Authorities, Rural Code, Environmental Code, Construction and Housing Code, Insurance Code, département-level health regulations, ministry circulars, and case law. VECTOR CONTROL AGAINST HUMAN HEALTH RIS...

  14. Insights into the experiences of patients with cancer in London: framework analysis of free-text data from the National Cancer Patient Experience Survey 2012/2013 from the two London Integrated Cancer Systems

    OpenAIRE

    Wiseman, Theresa; Lucas, Grace; Sangha, Amrit; Randolph, Anuska; Stapleton, Sarah; Pattison, Natalie; O'Gara, Geraldine; Harris, Katherine; Pritchard-Jones, Kathy; Dolan, Shelley

    2015-01-01

    Objective To shed light on experiences of patients with cancer in London National Health Service (NHS) trusts that may not be fully captured in national survey data, to inform improvement action plans by these trusts. Design Framework analysis of free-text data from 2012/2013 National Cancer Patient Experience Survey (NCPES) from the 2 London Integrated Cancer Systems. Setting and participants Patients with a cancer diagnosis treated by the NHS across 27 trusts in London. ...

  15. Insights into the experiences of patients with cancer in London: framework analysis of free-text data from the National Cancer Patient Experience Survey 2012/2013 from the two London Integrated Cancer Systems

    OpenAIRE

    Wiseman, Theresa; Lucas, Grace; Sangha, Amrit; Randolph, Anuska; Stapleton, Sarah; Pattison, Natalie; O'Gara, Geraldine; Harris, Katherine; Pritchard-Jones, Kathy; Dolan, Shelley

    2015-01-01

    Objective To shed light on experiences of patients with cancer in London National Health Service (NHS) trusts that may not be fully captured in national survey data, to inform improvement action plans by these trusts. Design Framework analysis of free-text data from 2012/2013 National Cancer Patient Experience Survey (NCPES) from the 2 London Integrated Cancer Systems. Setting and participants Patients with a cancer diagnosis treated by the NHS across 27 trusts in London. Main outcome measure...

  16. Endometrial cancer following treatment for breast cancer: a case-control study in Denmark.

    OpenAIRE

    Ewertz, M.; S.G. Machado; Boice, J. D.; Jensen, O M

    1984-01-01

    To evaluate the risk of endometrial cancer subsequent to breast cancer, a case-control study was carried out in Denmark. Between 1943-1977, 115 cases of histologically confirmed endometrial carcinoma developed more than 3 months after the diagnosis of a primary breast cancer in 51,638 women. A total of 235 breast cancer patients with no second primary cancer were matched to the cases on age, calendar year of diagnosis, and survival with an intact uterus. Identification of cases and controls r...

  17. Interactive image segmentation framework based on control theory

    Science.gov (United States)

    Zhu, Liangjia; Kolesov, Ivan; Ratner, Vadim; Karasev, Peter; Tannenbaum, Allen

    2015-03-01

    Segmentation of anatomical structures in medical imagery is a key step in a variety of clinical applications. Designing a generic, automated method that works for various structures and imaging modalities is a daunting task. Instead of proposing a new specific segmentation algorithm, in this paper, we present a general design principle on how to integrate user interactions from the perspective of control theory. In this formulation, Lyapunov stability analysis is employed to design an interactive segmentation system. The effectiveness and robustness of the proposed method are demonstrated.

  18. Prostate Cancer Disparities throughout the Cancer Control Continuum

    Directory of Open Access Journals (Sweden)

    Kyle J. Dalton

    2013-11-01

    Full Text Available Prostate cancer (PCa is the most commonly diagnosed malignancy and the second leading cause of cancer deaths among men in the United States. The American Cancer Society estimates that 238,590 U.S. men will develop PCa and 29,720 men will die from the disease in 2013. PCa exhibits the most profound racial disparities of all cancers with African American men having a 70% higher incidence rate and more than two times higher mortality rate than Caucasian men. Published research on PCa disparities focuses on singular outcomes such as incidence, mortality or quality of life. The objective of this paper is to provide a comprehensive summary of the racial disparities found at each stage of the PCa Care Continuum which includes prevention, detection, treatments, and outcomes and survival. It focuses primarily on disparities among Caucasian (white and African American men.

  19. CoRoBa, a Multi Mobile Robot Control and Simulation Framework

    Directory of Open Access Journals (Sweden)

    Eric Colon

    2008-11-01

    Full Text Available This paper describes on-going development of a multi robot control framework named CoRoBa. CoRoBa is theoretically founded by reifying Real Time Design Patterns. It uses CORBA as its communication Middleware and consequently benefits from the interoperability of this standard. A multi-robot 3D simulator written in Java3D integrates seamlessly with this framework. Several demonstration applications have been developed to validate the design and implementation options.

  20. Defining Feasibility and Pilot Studies in Preparation for Randomised Controlled Trials: Development of a Conceptual Framework

    OpenAIRE

    Eldridge, Sandra M.; Lancaster, Gillian A.; Michael J. Campbell; Thabane, Lehana; Hopewell, Sally; Coleman, Claire L.; Bond, Christine M

    2016-01-01

    We describe a framework for defining pilot and feasibility studies focusing on studies conducted in preparation for a randomised controlled trial. To develop the framework, we undertook a Delphi survey; ran an open meeting at a trial methodology conference; conducted a review of definitions outside the health research context; consulted experts at an international consensus meeting; and reviewed 27 empirical pilot or feasibility studies. We initially adopted mutually exclusive definitions of ...

  1. Unified registration framework for cumulative dose assessment in cervical cancer across external beam radiotherapy and brachytherapy

    Science.gov (United States)

    Roy, Sharmili; Totman, John J.; Choo, Bok A.

    2016-03-01

    Dose accumulation across External Beam Radiotherapy (EBRT) and Brachytherapy (BT) treatment fractions in cervical cancer is extremely challenging due to structural dissimilarities and large inter-fractional anatomic deformations between the EBRT and BT images. The brachytherapy applicator and the bladder balloon, present only in the BT images, introduce missing structural correspondences for the underlying registration problem. Complex anatomical deformations caused by the applicator and the balloon, different rectum and bladder filling and tumor shrinkage compound the registration difficulties. Conventional free-form registration methods struggle to handle such topological differences. In this paper, we propose a registration pipeline that first transforms the original images to their distance maps based on segmentations of critical organs and then performs non-linear registration of the distance maps. The resulting dense deformation field is then used to transform the original anatomical image. The registration accuracy is evaluated on 27 image pairs from stage 2B-4A cervical cancer patients. The algorithm reaches a Hausdorff distance of close to 0:5 mm for the uterus, 2:2 mm for the bladder and 1:7 mm for the rectum when applied to (EBRT,BT) pairs, taken at time points more than three months apart. This generalized model-free framework can be used to register any combination of EBRT and BT images as opposed to methods in the literature that are tuned for either only (BT,BT) pair, or only (EBRT,EBRT) pair or only (BT,EBRT) pair. A unified framework for 3D dose accumulation across multiple EBRT and BT fractions is proposed to facilitate adaptive personalized radiation therapy.

  2. Motivational control of sign-tracking behaviour: A theoretical framework.

    Science.gov (United States)

    Anselme, Patrick

    2016-06-01

    Learning and motivation are two psychological processes allowing animals to form and express Pavlovian associations between a conditioned stimulus (CS) and an unconditioned stimulus (UCS). However, most models have attempted to capture the mechanisms of learning while neglecting the role that motivation (or incentive salience) may actively play in the expression of behaviour. There is now a body of neurobehavioural evidence showing that incentive salience represents a major determinant of Pavlovian performance. This article presents a motivational model of sign-tracking behaviour whose aim is to explain a wide range of behavioural effects, including those related to partial reinforcement, physiological changes, competition between CSs, and individual differences in responding to a CS. In this model, associative learning is assumed to determine the ability to produce a Pavlovian conditioned response rather than to control the strength and the quality of that response. The model is in keeping with the incentive salience hypothesis and will therefore be discussed in the context of dopamine's role in the brain. PMID:27016362

  3. Motivational control of sign-tracking behaviour: A theoretical framework.

    Science.gov (United States)

    Anselme, Patrick

    2016-06-01

    Learning and motivation are two psychological processes allowing animals to form and express Pavlovian associations between a conditioned stimulus (CS) and an unconditioned stimulus (UCS). However, most models have attempted to capture the mechanisms of learning while neglecting the role that motivation (or incentive salience) may actively play in the expression of behaviour. There is now a body of neurobehavioural evidence showing that incentive salience represents a major determinant of Pavlovian performance. This article presents a motivational model of sign-tracking behaviour whose aim is to explain a wide range of behavioural effects, including those related to partial reinforcement, physiological changes, competition between CSs, and individual differences in responding to a CS. In this model, associative learning is assumed to determine the ability to produce a Pavlovian conditioned response rather than to control the strength and the quality of that response. The model is in keeping with the incentive salience hypothesis and will therefore be discussed in the context of dopamine's role in the brain.

  4. Framework and Method for Controlling a Robotic System Using a Distributed Computer Network

    Science.gov (United States)

    Sanders, Adam M. (Inventor); Barajas, Leandro G. (Inventor); Permenter, Frank Noble (Inventor); Strawser, Philip A. (Inventor)

    2015-01-01

    A robotic system for performing an autonomous task includes a humanoid robot having a plurality of compliant robotic joints, actuators, and other integrated system devices that are controllable in response to control data from various control points, and having sensors for measuring feedback data at the control points. The system includes a multi-level distributed control framework (DCF) for controlling the integrated system components over multiple high-speed communication networks. The DCF has a plurality of first controllers each embedded in a respective one of the integrated system components, e.g., the robotic joints, a second controller coordinating the components via the first controllers, and a third controller for transmitting a signal commanding performance of the autonomous task to the second controller. The DCF virtually centralizes all of the control data and the feedback data in a single location to facilitate control of the robot across the multiple communication networks.

  5. A Multi-Functional Fully Distributed Control Framework for AC Microgrids

    DEFF Research Database (Denmark)

    Shafiee, Qobad; Nasirian, Vahidreza; Quintero, Juan Carlos Vasquez;

    2016-01-01

    This paper proposes a fully distributed control methodology for secondary control of AC microgrids. The control framework includes three modules: voltage regulator, reactive power regulator, and active power/frequency regulator. The voltage regulator module maintains the average voltage of the mi......This paper proposes a fully distributed control methodology for secondary control of AC microgrids. The control framework includes three modules: voltage regulator, reactive power regulator, and active power/frequency regulator. The voltage regulator module maintains the average voltage....../reactive power sharing. An AC microgrid is prototyped to experimentally validate the proposed control methodology against the load change, plug-and-play operation, and communication constraints such as delay, packet loss, and limited bandwidth....

  6. SPARCoC: a new framework for molecular pattern discovery and cancer gene identification.

    Directory of Open Access Journals (Sweden)

    Shiqian Ma

    Full Text Available It is challenging to cluster cancer patients of a certain histopathological type into molecular subtypes of clinical importance and identify gene signatures directly relevant to the subtypes. Current clustering approaches have inherent limitations, which prevent them from gauging the subtle heterogeneity of the molecular subtypes. In this paper we present a new framework: SPARCoC (Sparse-CoClust, which is based on a novel Common-background and Sparse-foreground Decomposition (CSD model and the Maximum Block Improvement (MBI co-clustering technique. SPARCoC has clear advantages compared with widely-used alternative approaches: hierarchical clustering (Hclust and nonnegative matrix factorization (NMF. We apply SPARCoC to the study of lung adenocarcinoma (ADCA, an extremely heterogeneous histological type, and a significant challenge for molecular subtyping. For testing and verification, we use high quality gene expression profiling data of lung ADCA patients, and identify prognostic gene signatures which could cluster patients into subgroups that are significantly different in their overall survival (with p-values < 0.05. Our results are only based on gene expression profiling data analysis, without incorporating any other feature selection or clinical information; we are able to replicate our findings with completely independent datasets. SPARCoC is broadly applicable to large-scale genomic data to empower pattern discovery and cancer gene identification.

  7. Cervical cancer control, priorities and new directions.

    NARCIS (Netherlands)

    Monsonego, J; Bosch, F.X.; Coursaget, P.; Cox, JT; Franco, E; Frazer, I; Sankaranarayanan, R; Schiller, J; Singer, A; Wright, TCJr; Kinney, W; Meijer, C.J.L.M.; Linder, J

    2004-01-01

    99% of cervical cancer is initiated by HPV infection. The estimated lifetime risk of cervical cancer is nevertheless relatively low (less than 1 in 20 for most community based studies). Although sensitivity and specificity of the available diagnostic techniques are suboptimal, screening for persiste

  8. Thrombosis in ovarian cancer: a case control study

    OpenAIRE

    Metcalf, R L; Fry, D J; Swindell, R.; McGurk, A; Clamp, A R; Jayson, G C; Hasan, J

    2014-01-01

    Background: Thrombotic events are common in cancer patients and have been associated with an adverse prognosis in large registry-based studies. Methods: A retrospective cohort of 417 patients with ovarian cancer treated at a tertiary cancer centre between 2006 and 2009 was studied to identify the incidence and risk factors for thrombotic events and the prognostic impact of thrombosis. Patient outcomes were evaluated against a matched control group without thrombosis. Results: Ninety-nine thro...

  9. oodOPT: A Semantics-Based Concurrency Control Framework for Fully-Replicated Architecture

    Institute of Scientific and Technical Information of China (English)

    YANG Guangxin; SHI Meilin

    2001-01-01

    Concurrency control has always been one of the most important issues in the design of synchronous groupware systems with fully-replicated architecture. An ideal strategy should be able to support natural and flexible human-to-computer and human-to-human interactions while maintaining the consistency of the system. This paper summarizes previous researches on this topic and points out the deficiencies of the existing results. A novel semantics-based concurrency control framework, oodOPT, is proposed. The main idea of the framework is to resolve conflicts by utilizing semantics of the operations and the accessed data objects. With this approach, complexities in concurrency control are shifted completely from application developers to the framework. Conflicts among operations on objects with different semantics and the strategies resolving these conflicts are analyzed. After describing the algorithm in full detail, the discussion ends up with a comparison with other related work and some considerations for open problems.

  10. Large-Scale CORBA-Distributed Software Framework for NIF Controls

    International Nuclear Information System (INIS)

    The Integrated Computer Control System (ICCS) is based on a scalable software framework that is distributed over some 325 computers throughout the NIF facility. The framework provides templates and services at multiple levels of abstraction for the construction of software applications that communicate via CORBA (Common Object Request Broker Architecture). Various forms of object-oriented software design patterns are implemented as templates to be extended by application software. Developers extend the framework base classes to model the numerous physical control points, thereby sharing the functionality defined by the base classes. About 56,000 software objects each individually addressed through CORBA are to be created in the complete ICCS. Most objects have a persistent state that is initialized at system start-up and stored in a database. Additional framework services are provided by centralized server programs that implement events, alerts, reservations, message logging, database/file persistence, name services, and process management. The ICCS software framework approach allows for efficient construction of a software system that supports a large number of distributed control points representing a complex control application

  11. Comparing, Optimising and Benchmarking Quantum Control Algorithms in a Unifying Programming Framework

    CERN Document Server

    Machnes, S; Glaser, S J; de Fouquieres, P; Gruslys, A; Schirmer, S; Schulte-Herbrueggen, T

    2010-01-01

    For paving the way to novel applications in quantum simulation, computation, and technology, increasingly large quantum systems have to be steered with high precision. It is a typical task amenable to numerical optimal control to turn the time course of pulses, i.e. piecewise constant control amplitudes, iteratively into an optimised shape. Here, we present the first comparative study of optimal control algorithms for a wide range of finite-dimensional applications. We focus on the most commonly used algorithms: GRAPE methods which update all controls concurrently, and KROTOV-type methods which do so sequentially. Guidelines for their use are given and open research questions are pointed out. --- Moreover we introduce a novel unifying algorithmic framework, DYNAMO (Dynamic Optimisation Platform) designed to provide the quantum-technology community with a convenient MATLAB-based toolset for optimal control. In addition, it gives researchers in optimal-control techniques a framework for benchmarking and compari...

  12. Promoting cancer control training in resource limited environments: Lagos, Nigeria.

    Science.gov (United States)

    Nwogu, C; Mahoney, M; George, S; Dy, G; Hartman, H; Animashaun, M; Popoola, A; Michalek, A

    2014-03-01

    In resource limited nations, cancer control is often a lower priority issue creating challenges for the prevention, early diagnosis, and treatment of cancer. Training and education are vital components of efforts to tackle this problem. A 3-day cancer control workshop was conducted at the Lagos State University Teaching Hospital (LASUTH), Nigeria, in 2013. The curriculum included didactic lectures, panel discussions, and interactive sessions on local cancer statistics, preventive strategies, cancer registries, screening and diagnostic options, and treatment approaches with limited resources (chemotherapy, radiotherapy, surgery, and palliative care) and several site-specific (breast, lung, cervical, prostate, and colon) topics. Pre-workshop and post-workshop questionnaires were completed by participants. Eighty-six percent of the 50 workshop participants completed at least one questionnaire. Participants were mainly nurses and physicians (89% of responders), and 40% reported >25 years of practice experience. The more common local needs identified were professional education (65%) and increasing public cancer awareness (63%). The greatest interest for future programs was on research collaborations (70%). An immediate impact of the workshop was the commencement of monthly tumor board conferences and a review of the current cancer registry data. Capacity building is critical for the execution of effective cancer control strategies. Conducting collaborative workshops represents a cost-effective means of launching programs and energizing the medical community to pursue ongoing education and research addressing the anticipated cancer epidemic on the African continent. PMID:24243400

  13. A FRAMEWORK OF SETTING UP GOAL CONTROL LIMITS OF TARGET COSTING FOR NON-NORMAL DISTRIBUTIONS

    Institute of Scientific and Technical Information of China (English)

    Hsin-Hung WU; Fong-Jung YU

    2007-01-01

    This study provides a framework of target costing to extend its original scope when the underlying distribution is non-normal. The new specification limits can be derived by listening to the market price from Taguchi loss function. Later, the new specification limits can be linked through the non-normality-based (C)pk value along with non-normality-based X-R control charts to derive goal control limits. Moreover, an example is provided to illustrate the usefulness of the proposed framework of target costing by relentlessly reducing cost and improving product quality to gain competitiveness in the marketplace.

  14. Epidemiological study of prostate cancer (EPICAP): a population-based case–control study in France

    International Nuclear Information System (INIS)

    Prostate cancer is the most common cancer in male in most Western countries, including France. Despite a significant morbidity and mortality to a lesser extent, the etiology of prostate cancer remains largely unknown. Indeed, the only well-established risk factors to date are age, ethnicity and a family history of prostate cancer. We present, here, the rationale and design of the EPIdemiological study of Prostate CAncer (EPICAP), a population-based case–control study specifically designed to investigate the role of environmental and genetic factors in prostate cancer. The EPICAP study will particularly focused on the role of circadian disruption, chronic inflammation, hormonal and metabolic factors in the occurrence of prostate cancer. EPICAP is a population-based case–control study conducted in the département of Hérault in France. Eligible cases are all cases of prostate cancers newly diagnosed in 2012-2013 in men less than 75 years old and residing in the département of Hérault at the time of diagnosis. Controls are men of the same age as the cases and living in the département of Hérault, recruited in the general population. The sample will include a total of 1000 incident cases of prostate cancer and 1000 population-based controls over a 3-year period (2012-2014). The cases and controls are face-to-face interviewed using a standardized computed assisted questionnaire. The questions focus primarily on usual socio-demographic characteristics, personal and family medical history, lifestyle, leisure activities, residential and occupational history. Anthropometric measures and biological samples are also collected for cases and controls. The EPICAP study aims to answer key questions in prostate cancer etiology: (1) role of circadian disruption through the study of working hours, chronotype and duration/quality of sleep, (2) role of chronic inflammation and anti-inflammatory drugs, (3) role of hormonal and metabolic factors through a detailed questionnaire

  15. Implementation of MADOCA II control framework into SPring-8 and the extension functions

    International Nuclear Information System (INIS)

    We developed MADOCA II for the next-generation MADOCA control framework at SPring-8 as reported at the last PASJ meeting. In MADOCA II, new functions such as messaging with a variable length data, and controls on Windows, were implemented to have high flexibility in our control system. In this proceeding, we report the implementation of MADOCA II control framework into SPring-8, which is our next milestone. On April 2014, we succeeded to start operation by replacing all operator workstations with MADOCA II. The replacements of front-end computers (VME etc.) with MADOCA II are now in progress and were partially performed in vacuum system etc. We also report the extension functions in MADOCA II. To have high flexibility in access control at SACLA BL, the messaging scheme was extended to perform message routing via multiple hosts. To handle various data in the messaging with the unified procedure, we developed general-purpose data format using MessagePack. (author)

  16. Risk Factors for Pancreatic Cancer in China: A Multicenter Case-Control Study

    OpenAIRE

    Zhaoxu Zheng

    2016-01-01

    Background: Despite having one of the highest mortality rates of all cancers, the risk factors of pancreatic cancer remain unclear. We assessed risk factors of pancreatic cancer in China. Methods: A case-control study design was conducted using data from four hospital-based cancer registries (Henan Provincial Cancer Hospital, Beijing Cancer Hospital, Hebei Provincial Cancer Hospital, and Cancer Hospital of Chinese Academy of Medical Sciences). Controls were equally matched and selected fro...

  17. Generalized Gramian Framework for Model/Controller Order Reduction of Switched Systems

    DEFF Research Database (Denmark)

    Shaker, Hamid Reza; Wisniewski, Rafal

    2011-01-01

    In this article, a general method for model/controller order reduction of switched linear dynamical systems is presented. The proposed technique is based on the generalised gramian framework for model reduction. It is shown that different classical reduction methods can be developed...... into a generalised gramian framework. Balanced reduction within a specified frequency bound is developed within this framework. In order to avoid numerical instability and also to increase the numerical efficiency, generalised gramian-based Petrov–Galerkin projection is constructed instead of the similarity...... and controller reduction. Furthermore, it is applicable to both continuous and discrete time systems for different classical gramian-based reduction methods. The performance of the proposed method is illustrated by numerical examples....

  18. A Framework of Environmental Modelling and Information Sharing for Urban Air Pollution Control and Management

    Institute of Scientific and Technical Information of China (English)

    LIU Gang-jun; FU Er-jiang; WANG Yun-jia; ZHANG Ke-fei; HAN Bao-ping; ARROWSMITH Colin

    2007-01-01

    More effective environmental pollution control and management are needed due to the increasing environmental impacts from a range of human activities and the growing public demands for a better living environment. Urban air pollution is a serious environmental issue that poses adverse impacts on the health of people and the environment in most metropolitan areas. In this paper, we propose a geoinformatics augmented framework of environmental modelling and information sharing for supporting effective urban air pollution control and management. This framework is outlined in terms of its key components and processes including: 1) an integrated, adaptive network of sensors for environmental monitoring; 2) a set of distributed, interoperable databases for data management; 3) a set of intelligent, robust algorithms and models for environmental modelling; 4) a set of flexible, efficient user interfaces for data access and information sharing; and 5) a reliable, high capacity, high performance computing and communication infrastructure for integrating and supporting other framework components and processes.

  19. A national agenda for Latino cancer prevention and control.

    Science.gov (United States)

    Ramirez, Amelie G; Gallion, Kipling J; Suarez, Lucina; Giachello, Aida L; Marti, Jose R; Medrano, Martha A; Pérez-Stable, Eliseo J; Talavera, Gregory A; Trapido, Edward J

    2005-06-01

    Although cancer is a leading cause of morbidity and premature death among Latinos, there is limited knowledge of cancer-related issues and priorities of greatest significance to the Latino population, the largest minority group in the nation. This information is vital in helping to guide Latino cancer research, training, and awareness efforts at national, regional, and local levels. To help identify cancer issues of greatest relevance to Latinos, Redes En Accion, The National Hispanic/Latino Cancer Network, a major network among the National Cancer Institute's Special Populations Networks, conducted a survey of 624 key opinion leaders from around the country. Respondents were asked to rank the three cancer sites most important to Latinos in their region and the five issues of greatest significance for this population's cancer prevention and control. Recommendations were prioritized for three specific areas: 1) research, 2) training and/or professional education, and 3) awareness and/or public education. Among cancers, breast carcinoma was ranked number one, followed in order by cervical and lung carcinomas. The issues of greatest significance to Latinos were 1) access to cancer screening and care, 2) tobacco use, 3) patient-doctor communication, 4) nutrition, and 5) risk communication. This survey solicited information from scientists, health care professionals, leaders of government agencies, professional and community-based organizations, and other stakeholders in Latino health. The results laid the foundation for a national Redes En Accion Latino cancer agenda, thus providing a useful tool for individuals and organizations engaged in cancer prevention and control efforts among the Hispanic-Latino population. PMID:15822119

  20. A national agenda for Latino cancer prevention and control.

    Science.gov (United States)

    Ramirez, Amelie G; Gallion, Kipling J; Suarez, Lucina; Giachello, Aida L; Marti, Jose R; Medrano, Martha A; Pérez-Stable, Eliseo J; Talavera, Gregory A; Trapido, Edward J

    2005-06-01

    Although cancer is a leading cause of morbidity and premature death among Latinos, there is limited knowledge of cancer-related issues and priorities of greatest significance to the Latino population, the largest minority group in the nation. This information is vital in helping to guide Latino cancer research, training, and awareness efforts at national, regional, and local levels. To help identify cancer issues of greatest relevance to Latinos, Redes En Accion, The National Hispanic/Latino Cancer Network, a major network among the National Cancer Institute's Special Populations Networks, conducted a survey of 624 key opinion leaders from around the country. Respondents were asked to rank the three cancer sites most important to Latinos in their region and the five issues of greatest significance for this population's cancer prevention and control. Recommendations were prioritized for three specific areas: 1) research, 2) training and/or professional education, and 3) awareness and/or public education. Among cancers, breast carcinoma was ranked number one, followed in order by cervical and lung carcinomas. The issues of greatest significance to Latinos were 1) access to cancer screening and care, 2) tobacco use, 3) patient-doctor communication, 4) nutrition, and 5) risk communication. This survey solicited information from scientists, health care professionals, leaders of government agencies, professional and community-based organizations, and other stakeholders in Latino health. The results laid the foundation for a national Redes En Accion Latino cancer agenda, thus providing a useful tool for individuals and organizations engaged in cancer prevention and control efforts among the Hispanic-Latino population.

  1. What predicts intention-behavior discordance? A review of the action control framework

    NARCIS (Netherlands)

    R.E. Rhodes; G.J. de Bruijn

    2013-01-01

    The physical activity intention-behavior gap is a focus of considerable research. The purpose of this article is to overview contemporary evidence for predictors of this intention-behavior discordance using the action control framework developed in our laboratories. We propose the hypothesis that in

  2. Fast Data Sharing within a distributed multithreaded control framework for robot teams

    NARCIS (Netherlands)

    Seesink, Remco; Dierssen, Werner; Kooij, Niek; Schoute, Albert; Poel, Mannes; Schepers, Erik; Verschoor, Thijs

    2003-01-01

    In this paper a data sharing framework for multithreaded, distributed control programs is described that is realized in C++ by means of only a few, powerful classes and templates. Fast data exchange of entire data structures is supported using sockets as communication medium. Access methods are prov

  3. Fast Data Sharing within a distributed multithreaded control framework for robot teams

    NARCIS (Netherlands)

    Schoute, Albert; Seesink, Remco; Dierssen, Werner; Kooij, Niek; Broenink, Jan; Roebbers, Herman; Sunter, Johan; Welch, Peter; Wood, David

    2005-01-01

    In this paper a data sharing framework for multi-threaded, distributed control programs is described that is realized in C++ by means of only a few, powerful classes and templates. Fast data exchange of entire data structures is supported using sockets as communication medium. Access methods are pro

  4. Modelling supported driving as an optimal control cycle: Framework and model characteristics

    CERN Document Server

    Wang, Meng; Daamen, Winnie; Hoogendoorn, Serge P; van Arem, Bart

    2014-01-01

    Driver assistance systems support drivers in operating vehicles in a safe, comfortable and efficient way, and thus may induce changes in traffic flow characteristics. This paper puts forward a receding horizon control framework to model driver assistance and cooperative systems. The accelerations of automated vehicles are controlled to optimise a cost function, assuming other vehicles driving at stationary conditions over a prediction horizon. The flexibility of the framework is demonstrated with controller design of Adaptive Cruise Control (ACC) and Cooperative ACC (C-ACC) systems. The proposed ACC and C-ACC model characteristics are investigated analytically, with focus on equilibrium solutions and stability properties. The proposed ACC model produces plausible human car-following behaviour and is unconditionally locally stable. By careful tuning of parameters, the ACC model generates similar stability characteristics as human driver models. The proposed C-ACC model results in convective downstream and abso...

  5. Symptom control in the pregnant cancer patient.

    Science.gov (United States)

    MacDougall, M K; LeGrand, S B; Walsh, D

    2000-12-01

    While much attention has been devoted to cytotoxic drugs and radiation therapy in the pregnant cancer patient, the drugs used for management of symptoms and complications related to cancer during pregnancy have been overlooked. There is substantial overlap between the symptoms of cancer and cancer management and the symptoms related to pregnancy. The mainstay of symptom management is drug therapy and the potential for a drug to be embryotoxic or teratogenic depends on when it is given. In general, drugs not proven safe in pregnancy should be withheld, especially during the first trimester. The few drugs that have been proven to be teratogenic are alcohol, thalidomide, the folic acid antagonists (which includes methotrexate), diethylstilbestrol, and the vitamin A isomers, but there is a good deal of uncertainty about many other therapeutic agents. Placental transport of drugs from mother to fetus must be taken into consideration from the fifth week of gestation to parturition. Although the first trimester is the time of most organ development in the fetus, the brain continues to develop throughout pregnancy and may be damaged later in pregnancy, resulting in diminished intelligence or behavioral problems. This review will focus on the treatment of the most common symptoms of cancer in a pregnant patient and the potential for fetal damage. PMID:11130478

  6. Simultaneously stabilising controllers for time-varying linear systems within the framework of nest algebras

    Science.gov (United States)

    Wang, Hongzhu; Yu, Tianqiu; Xiao, Jinmei

    2016-08-01

    From the perspective of strong transitivity, a controller design method is provided to simultaneously stabilise a collection of time-varying linear systems within the framework of nest algebras. In particular, all simultaneously stabilising controllers for a class of linear plants are characterised based on the doubly coprime factorisations. These results hold as well in the time-invariant case. An illustrative example is given to demonstrate the validity of the method.

  7. Thinking as the Control of Imagination: a Conceptual Framework for Goal-Directed Systems

    OpenAIRE

    Pezzulo, Giovanni; Castelfranchi, Cristiano

    2009-01-01

    This paper offers a conceptual framework which (re)integrates goal-directed control, motivational processes, and executive functions, and suggests a developmentalpathway from situated action to higher level cognition. We first illustrate a basic computational (control-theoretic) model of goal-directed action that makes use of internalmodeling. We then show that by adding the problem of selection among multiple actionalternatives motivation enters the scene, and that the basic mechanisms of ex...

  8. A human rights view on access to controlled substances for medical purposes under the international drug control framework.

    Science.gov (United States)

    Gispen, Marie Elske C

    2013-11-01

    The world is confronted with a major public health deficit caused by poor access to controlled essential medicines under the international drug control framework. This is affecting millions of patients on a daily basis and resulting in numerous human rights violations. The present review contextualises this deficit from a human rights perspective. Drug control efforts are informed by a twofold objective stemming from the double nature of scheduled substances: free access for medical purposes should be ensured, though non-medical use of substances such as opium should be restricted. The international drug control framework is, in theory, based on this twofold notion, however at the level of interpretation, monitoring, and implementation, a one-sided emphasis is demonstrated. By tracing a parallel between the obligations of states under the international drug control framework and those that derive from human rights law, the review shows that the two systems seem incoherent and conflicting in nature and flags the importance of cross-disciplinary research into drug control and human rights.

  9. New Cancer Prevention and Control Central Institutional Review Board Established | Division of Cancer Prevention

    Science.gov (United States)

    The NCI Central Institutional Review Board (CIRB) Initiative announced the establishment of the Cancer Prevention and Control (CPC) CIRB January 14, extending the benefits of centralized review to investigators participating in clinical trials sponsored by the Division of Cancer Prevention (DCP). |

  10. CPFP Summer Curriculum: Principles and Practices of Cancer Prevention and Control Course | Division of Cancer Prevention

    Science.gov (United States)

    This Cancer Prevention Fellowship Program four-week summer course provides specialized instruction in the principles and practice of cancer prevention and control. Participants will gain a broad-based perspective on concepts, issues, and applications related to this field. The course typically covers the following topics: |

  11. Cancer preceding Wegener's granulomatosis: a case-control study

    DEFF Research Database (Denmark)

    Faurschou, Mikkel; Mellemkjaer, Lene; Sørensen, Inge Juul;

    2009-01-01

    OBJECTIVE: To investigate whether patients with WG have an increased risk of malignancies prior to and/or around the time of the vasculitis diagnosis, as suggested by previous studies. METHODS: A total of 293 WG patients were included in the study. Ten gender- and age-matched controls were selected...... randomly for each patient from the Danish Central Population Register. Information on malignancies was obtained through the Danish Cancer Registry. Occurrence of malignancies before WG diagnosis among patients and before WG diagnosis of their matched case among controls (reference date) was compared...... by calculation of prevalence odds ratios (OR). RESULTS: Twenty-six patients were diagnosed with cancer before WG, while 194 controls were diagnosed with cancer before the reference date (OR 1.4; 95% CI 0.9, 2.2). Among specific malignancies, a significantly increased prevalence was found for testis cancer (OR 6...

  12. Cancer specificity of promoters of the genes controlling cell proliferation.

    Science.gov (United States)

    Kashkin, Kirill; Chernov, Igor; Stukacheva, Elena; Monastyrskaya, Galina; Uspenskaya, Natalya; Kopantzev, Eugene; Sverdlov, Eugene

    2015-02-01

    Violation of proliferation control is a common feature of cancer cells. We put forward the hypothesis that promoters of genes involved in the control of cell proliferation should possess intrinsic cancer specific activity. We cloned promoter regions of CDC6, POLD1, CKS1B, MCM2, and PLK1 genes into pGL3 reporter vector and studied their ability to drive heterologous gene expression in transfected cancer cells of different origin and in normal human fibroblasts. Each promoter was cloned in short (335-800 bp) and long (up to 2.3 kb) variants to cover probable location of core and whole promoter regulatory elements. Cloned promoters were significantly more active in cancer cells than in normal fibroblasts that may indicate their cancer specificity. Both versions of CDC6 promoters were shown to be most active while the activities of others were close to that of BIRC5 gene (survivin) gene promoter. Long and short variants of each cloned promoter demonstrated very similar cancer specificity with the exception of PLK1-long promoter that was substantially more specific than its short variant and other promoters under study. The data indicate that most of the important cis-regulatory transcription elements responsible for intrinsic cancer specificity are located in short variants of the promoters under study. CDC6 short promoter may serve as a promising candidate for transcription targeted cancer gene therapy.

  13. A Functional Analysis Framework for Modeling, Estimation and Control in Science and Engineering

    CERN Document Server

    Banks, HT

    2012-01-01

    A Modern Framework Based on Time-Tested Material A Functional Analysis Framework for Modeling, Estimation and Control in Science and Engineering presents functional analysis as a tool for understanding and treating distributed parameter systems. Drawing on his extensive research and teaching from the past 20 years, the author explains how functional analysis can be the basis of modern partial differential equation (PDE) and delay differential equation (DDE) techniques. Recent Examples of Functional Analysis in Biology, Electromagnetics, Materials, and Mechanics Through numerous application exa

  14. Pain Control: Support for People with Cancer

    Science.gov (United States)

    ... talk about your pain with your health care team How to make your pain control plan work for you Pain control medicines and side effects Medicine tolerance is not addiction Other ways to control pain ...

  15. CORBA-Based Distributed Software Framework for the NIF Integrated Computer Control System

    International Nuclear Information System (INIS)

    The National Ignition Facility (NIF), currently under construction at the Lawrence Livermore National Laboratory, is a stadium-sized facility containing a 192-beam, 1.8 Megajoule, 500-Terawatt, ultra-violet laser system together with a 10-meter diameter target chamber with room for nearly 100 experimental diagnostics. The NIF is operated by the Integrated Computer Control System (ICCS) which is a scalable, framework-based control system distributed over 800 computers throughout the NIF. The framework provides templates and services at multiple levels of abstraction for the construction of software applications that communicate via CORBA (Common Object Request Broker Architecture). Object-oriented software design patterns are implemented as templates and extended by application software. Developers extend the framework base classes to model the numerous physical control points and implement specializations of common application behaviors. An estimated 140 thousand software objects, each individually addressable through CORBA, will be active at full scale. Many of these objects have persistent configuration information stored in a database. The configuration data is used to initialize the objects at system start-up. Centralized server programs that implement events, alerts, reservations, data archival, name service, data access, and process management provide common system wide services. At the highest level, a model-driven, distributed shot automation system provides a flexible and scalable framework for automatic sequencing of work-flow for control and monitoring of NIF shots. The shot model, in conjunction with data defining the parameters and goals of an experiment, describes the steps to be performed by each subsystem in order to prepare for and fire a NIF shot. Status and usage of this distributed framework are described

  16. CORBA-based distributed software framework for the NIF integrated computer control system

    International Nuclear Information System (INIS)

    The National Ignition Facility (NIF), currently under construction at the Lawrence Livermore National Laboratory, is a stadium-sized facility containing a 192-beam, 1.8 MJ, 500 TW, ultra-violet laser system together with a 10-meter diameter target chamber with room for nearly 100 experimental diagnostics. The NIF is operated by the Integrated Computer Control System (ICCS) which is a scalable, framework-based control system distributed over 800 computers throughout the NIF. The framework provides templates and services at multiple levels of abstraction for the construction of software applications that communicate via CORBA (Common Object Request Broker Architecture). Object-oriented software design patterns are implemented as templates and extended by application software. Developers extend the framework base classes to model the numerous physical control points and implement specializations of common application behaviors. An estimated 140,000 software objects, each individually addressable through CORBA, will be active at full scale. Many of these objects have persistent configuration information stored in a database. The configuration data is used to initialize the objects at system start-up. Centralized server programs that implement events, alerts, reservations, data archival, name service, data access, and process management provide common system wide services. At the highest level, a model-driven, distributed shot automation system provides a flexible and scalable framework for automatic sequencing of workflow for control and monitoring of NIF shots. The shot model, in conjunction with data defining the parameters and goals of an experiment, describes the steps to be performed by each subsystem in order to prepare for and fire a NIF shot. Status and usage of this distributed framework are described

  17. CORBA-based distributed software framework for the NIF integrated computer control system

    Energy Technology Data Exchange (ETDEWEB)

    Stout, E.A. [Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94550 (United States)], E-mail: stout6@llnl.gov; Carey, R.W.; Estes, C.M.; Fisher, J.M.; Lagin, L.J.; Mathisen, D.G.; Reynolds, C.A.; Sanchez, R.J. [Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94550 (United States)

    2008-04-15

    The National Ignition Facility (NIF), currently under construction at the Lawrence Livermore National Laboratory, is a stadium-sized facility containing a 192-beam, 1.8 MJ, 500 TW, ultra-violet laser system together with a 10-meter diameter target chamber with room for nearly 100 experimental diagnostics. The NIF is operated by the Integrated Computer Control System (ICCS) which is a scalable, framework-based control system distributed over 800 computers throughout the NIF. The framework provides templates and services at multiple levels of abstraction for the construction of software applications that communicate via CORBA (Common Object Request Broker Architecture). Object-oriented software design patterns are implemented as templates and extended by application software. Developers extend the framework base classes to model the numerous physical control points and implement specializations of common application behaviors. An estimated 140,000 software objects, each individually addressable through CORBA, will be active at full scale. Many of these objects have persistent configuration information stored in a database. The configuration data is used to initialize the objects at system start-up. Centralized server programs that implement events, alerts, reservations, data archival, name service, data access, and process management provide common system wide services. At the highest level, a model-driven, distributed shot automation system provides a flexible and scalable framework for automatic sequencing of workflow for control and monitoring of NIF shots. The shot model, in conjunction with data defining the parameters and goals of an experiment, describes the steps to be performed by each subsystem in order to prepare for and fire a NIF shot. Status and usage of this distributed framework are described.

  18. CORBA-Based Distributed Software Framework for the NIF Integrated Computer Control System

    Energy Technology Data Exchange (ETDEWEB)

    Stout, E A; Carey, R W; Estes, C M; Fisher, J M; Lagin, L J; Mathisen, D G; Reynolds, C A; Sanchez, R J

    2007-11-20

    The National Ignition Facility (NIF), currently under construction at the Lawrence Livermore National Laboratory, is a stadium-sized facility containing a 192-beam, 1.8 Megajoule, 500-Terawatt, ultra-violet laser system together with a 10-meter diameter target chamber with room for nearly 100 experimental diagnostics. The NIF is operated by the Integrated Computer Control System (ICCS) which is a scalable, framework-based control system distributed over 800 computers throughout the NIF. The framework provides templates and services at multiple levels of abstraction for the construction of software applications that communicate via CORBA (Common Object Request Broker Architecture). Object-oriented software design patterns are implemented as templates and extended by application software. Developers extend the framework base classes to model the numerous physical control points and implement specializations of common application behaviors. An estimated 140 thousand software objects, each individually addressable through CORBA, will be active at full scale. Many of these objects have persistent configuration information stored in a database. The configuration data is used to initialize the objects at system start-up. Centralized server programs that implement events, alerts, reservations, data archival, name service, data access, and process management provide common system wide services. At the highest level, a model-driven, distributed shot automation system provides a flexible and scalable framework for automatic sequencing of work-flow for control and monitoring of NIF shots. The shot model, in conjunction with data defining the parameters and goals of an experiment, describes the steps to be performed by each subsystem in order to prepare for and fire a NIF shot. Status and usage of this distributed framework are described.

  19. Hierarchical Brokering with Feedback Control Framework in Mobile Device-Centric Clouds

    Directory of Open Access Journals (Sweden)

    Chao-Lieh Chen

    2016-01-01

    Full Text Available We propose a hierarchical brokering architecture (HiBA and Mobile Multicloud Networking (MMCN feedback control framework for mobile device-centric cloud (MDC2 computing. Exploiting the MMCN framework and RESTful web-based interconnection, each tier broker probes resource state of its federation for control and management. Real-time and seamless services were developed. Case studies including intrafederation energy-aware balancing based on fuzzy feedback control and higher tier load balancing are further demonstrated to show how HiBA with MMCN relieves the embedding of algorithms when developing services. Theoretical performance model and real-world experiments both show that an MDC2 based on HiBA features better quality in terms of resource availability and network latency if it federates devices with enough resources distributed in lower tier hierarchy. The proposed HiBA realizes a development platform for MDC2 computing which is a feasible solution to User-Centric Networks (UCNs.

  20. Breaking and Fixing Origin-Based Access Control in Hybrid Web/Mobile Application Frameworks.

    Science.gov (United States)

    Georgiev, Martin; Jana, Suman; Shmatikov, Vitaly

    2014-02-01

    Hybrid mobile applications (apps) combine the features of Web applications and "native" mobile apps. Like Web applications, they are implemented in portable, platform-independent languages such as HTML and JavaScript. Like native apps, they have direct access to local device resources-file system, location, camera, contacts, etc. Hybrid apps are typically developed using hybrid application frameworks such as PhoneGap. The purpose of the framework is twofold. First, it provides an embedded Web browser (for example, WebView on Android) that executes the app's Web code. Second, it supplies "bridges" that allow Web code to escape the browser and access local resources on the device. We analyze the software stack created by hybrid frameworks and demonstrate that it does not properly compose the access-control policies governing Web code and local code, respectively. Web code is governed by the same origin policy, whereas local code is governed by the access-control policy of the operating system (for example, user-granted permissions in Android). The bridges added by the framework to the browser have the same local access rights as the entire application, but are not correctly protected by the same origin policy. This opens the door to fracking attacks, which allow foreign-origin Web content included into a hybrid app (e.g., ads confined in iframes) to drill through the layers and directly access device resources. Fracking vulnerabilities are generic: they affect all hybrid frameworks, all embedded Web browsers, all bridge mechanisms, and all platforms on which these frameworks are deployed. We study the prevalence of fracking vulnerabilities in free Android apps based on the PhoneGap framework. Each vulnerability exposes sensitive local resources-the ability to read and write contacts list, local files, etc.-to dozens of potentially malicious Web domains. We also analyze the defenses deployed by hybrid frameworks to prevent resource access by foreign-origin Web content

  1. Case-control study of fetal microchimerism and breast cancer.

    Directory of Open Access Journals (Sweden)

    Vijayakrishna K Gadi

    Full Text Available BACKGROUND: Prior pregnancy is known to protect against development of breast cancer. Recent studies have demonstrated that pregnancy has the capacity to establish small numbers of immunologically active fetal-derived cells in the mother, a phenomenon known as fetal microchimerism (FMc. We asked whether presence of FMc, routinely acquired during pregnancy, is a protective factor for breast cancer. METHODOLOGY/PRINCIPAL FINDINGS: DNA extracts from peripheral blood specimens were obtained from a population-based case-control study of risk factors for breast cancer in women 21 to 45 years old. Specimens were tested with quantitative PCR for presence and concentrations of male DNA presumed to derive from prior pregnancies with a male fetus. Odds ratios (OR and 95% confidence intervals (CI were estimated with consideration of multiple established reproductive and environmental risk factors for breast cancer. FMc results were generated on 99 parous women, 54 with primary invasive breast cancer and 45 general population controls. FMc prevalence was 56% (25/45 and 26% (14/54 in controls and cases, respectively. Women harboring FMc were less likely to have had breast cancer (OR = 0.29, 95% CI 0.11-0.83; p = 0.02, adjusting for age, number of children, birth of a son, history of miscarriage, and total DNA tested. In addition, FMc concentrations were higher in controls versus cases (p = 0.01. Median concentrations were 2 (0-78 and 0 (0-374 fetal genomes/10(6 maternal genomes in controls and cases, respectively. CONCLUSIONS: Results suggest that the enigma of why some parous women are not afforded protection from breast cancer by pregnancy might in part be explained by differences in FMc. Mechanistic studies of FMc-derived protection against breast cancer are warranted.

  2. A modular robust control framework for control of movement elicited by multi-electrode intraspinal microstimulation

    Science.gov (United States)

    Roshani, Amir; Erfanian, Abbas

    2016-08-01

    Objective. An important issue in restoring motor function through intraspinal microstimulation (ISMS) is the motor control. To provide a physiologically plausible motor control using ISMS, it should be able to control the individual motor unit which is the lowest functional unit of motor control. By focal stimulation only a small group of motor neurons (MNs) within a motor pool can be activated. Different groups of MNs within a motor pool can potentially be activated without involving adjacent motor pools by local stimulation of different parts of a motor pool via microelectrode array implanted into a motor pool. However, since the system has multiple inputs with single output during multi-electrode ISMS, it poses a challenge to movement control. In this paper, we proposed a modular robust control strategy for movement control, whereas multi-electrode array is implanted into each motor activation pool of a muscle. Approach. The controller was based on the combination of proportional-integral-derivative and adaptive fuzzy sliding mode control. The global stability of the controller was guaranteed. Main results. The results of the experiments on rat models showed that the multi-electrode control can provide a more robust control and accurate tracking performance than a single-electrode control. The control output can be pulse amplitude (pulse amplitude modulation, PAM) or pulse width (pulse width modulation, PWM) of the stimulation signal. The results demonstrated that the controller with PAM provided faster convergence rate and better tracking performance than the controller with PWM. Significance. This work represents a promising control approach to the restoring motor functions using ISMS. The proposed controller requires no prior knowledge about the dynamics of the system to be controlled and no offline learning phase. The proposed control design is modular in the sense that each motor pool has an independent controller and each controller is able to control ISMS

  3. Cancer Pain Control for Advanced Cancer Patients by Using Autonomic Nerve Pharmacopuncture

    Directory of Open Access Journals (Sweden)

    Hwi-joong Kang

    2014-09-01

    Full Text Available Objectives: The purpose of this study is to report a case series of advanced cancer patients whose cancer pain was relieved by using autonomic nerve pharmacopuncture (ANP treatment. ANP is a subcutaneous injection therapy of mountain ginseng pharmacopuncture (MGP along the acupoints on the spine (Hua-Tuo-Jia-Ji-Xue; 0.5 cun lateral to the lower border of the spinous processes of vertebrae to enhance the immune system and to balance autonomic nerve function. Methods: Patients with three different types of cancer (gastric cancer, lung cancer, colon cancer with distant metastases with cancer pain were treated with ANP. 1 mL of MGP was injected into the bilateral Hua-Tuo-Jia-Ji-Xue on the T1-L5 sites (total 12 ─ 20 mL injection of each patient’s dorsum by using the principle of symptom differentiation. During ANP treatment, the visual analogue scale (VAS for pain was used to assess their levels of cancer pain; also, the dosage and the frequency of analgesic use were measured. Results: The cancer pain levels of all three patients improved with treatment using ANP. The VAS scores of the three patients decreased as the treatment progressed. The dosage and the frequency of analgesics also gradually decreased during the treatment period. Significantly, no related adverse events were found. Conclusion: ANP has shown benefit in controlling cancer pain for the three different types of cancer investigated in this study and in reducing the dosage and the frequency of analgesics. ANP is expected to be beneficial for reducing cancer pain and, thus, to be a promising new treatment for cancer pain.

  4. Software Architecture and Framework for Programmable Logic Controllers: A Case Study and Suggestions for Research

    Directory of Open Access Journals (Sweden)

    E. George Walters

    2016-06-01

    Full Text Available Programmable Logic Controllers (PLCs are widely used for control and automation of machines and processes, so the quality of PLC software has a direct impact on production efficiency. This paper describes a PLC program for a food production line that was completely rewritten using a different software architecture and framework. The PLC hardware and the production line equipment were not changed, so this project provides an opportunity to quantify the impact of different PLC software architecture on production efficiency. The average number of cases of products produced per production hour during the first ten months with the new program was 6.1% higher than the average during the previous ten months with the old program. PLC software, unlike most other software, is often used by the end-user for troubleshooting. In this case, a relatively simple architecture and framework that favors the end-user significantly improved production efficiency over a more sophisticated architecture and framework that favors the software developer. Suggestions for further research on software architecture and framework are given.

  5. Development of a Framework for the Evaluation of the Environmental Benefits of Controlled Traffic Farming

    Directory of Open Access Journals (Sweden)

    Abdul Mounem Mouazen

    2015-07-01

    Full Text Available Although controlled traffic farming (CTF is an environmentally friendly soil management system, no quantitative evaluation of environmental benefits is available. This paper aims at establishing a framework for quantitative evaluation of the environmental benefits of CTF, considering a list of environmental benefits, namely, reducing soil compaction, runoff/erosion, energy requirement and greenhouse gas emission (GHG, conserving organic matter, enhancing soil biodiversity and fertiliser use efficiency. Based on a comprehensive literature review and the European Commission Soil Framework Directive, the choice of and the weighting of the impact of each of the environmental benefits were made. The framework was validated using data from three selected farms. For Colworth farm (Unilever, UK, the framework predicted the largest overall environmental benefit of 59.3% of the theoretically maximum achievable benefits (100%, as compared to the other two farms in Scotland (52% and Australia (47.3%. This overall benefit could be broken down into: reducing soil compaction (24%, tillage energy requirement (10% and GHG emissions (3%, enhancing soil biodiversity (7% and erosion control (6%, conserving organic matter (6%, and improving fertiliser use efficiency (3%. Similar evaluation can be performed for any farm worldwide, providing that data on soil properties, topography, machinery, and weather are available.

  6. Who controls the ATP supply in cancer cells? Biochemistry lessons to understand cancer energy metabolism.

    Science.gov (United States)

    Moreno-Sánchez, Rafael; Marín-Hernández, Alvaro; Saavedra, Emma; Pardo, Juan P; Ralph, Stephen J; Rodríguez-Enríquez, Sara

    2014-05-01

    Applying basic biochemical principles, this review analyzes data that contrasts with the Warburg hypothesis that glycolysis is the exclusive ATP provider in cancer cells. Although disregarded for many years, there is increasing experimental evidence demonstrating that oxidative phosphorylation (OxPhos) makes a significant contribution to ATP supply in many cancer cell types and under a variety of conditions. Substrates oxidized by normal mitochondria such as amino acids and fatty acids are also avidly consumed by cancer cells. In this regard, the proposal that cancer cells metabolize glutamine for anabolic purposes without the need for a functional respiratory chain and OxPhos is analyzed considering thermodynamic and kinetic aspects for the reductive carboxylation of 2-oxoglutarate catalyzed by isocitrate dehydrogenase. In addition, metabolic control analysis (MCA) studies applied to energy metabolism of cancer cells are reevaluated. Regardless of the experimental/environmental conditions and the rate of lactate production, the flux-control of cancer glycolysis is robust in the sense that it involves the same steps: glucose transport, hexokinase, hexosephosphate isomerase and glycogen degradation, all at the beginning of the pathway; these steps together with phosphofructokinase 1 also control glycolysis in normal cells. The respiratory chain complexes exert significantly higher flux-control on OxPhos in cancer cells than in normal cells. Thus, determination of the contribution of each pathway to ATP supply and/or the flux-control distribution of both pathways in cancer cells is necessary in order to identify differences from normal cells which may lead to the design of rational alternative therapies that selectively target cancer energy metabolism. PMID:24513530

  7. Science and society: the communications revolution and cancer control.

    Science.gov (United States)

    Viswanath, K

    2005-10-01

    Advances in communications technology, particularly with regards to computer-based media, have opened up exciting possibilities to intervene and influence the trajectory of cancer control, from disease prevention to survivorship, and to reduce the cancer burden. The resulting explosion in cancer information in the mass media and on the Internet, however, also offers challenges in terms of equality in access to information and the ability to act on it, as well as in making sure that it is accurate, readily available and easy to use. PMID:16195753

  8. An Ethical Framework for Allocating Scarce Life-Saving Chemotherapy and Supportive Care Drugs for Childhood Cancer.

    Science.gov (United States)

    Unguru, Yoram; Fernandez, Conrad V; Bernhardt, Brooke; Berg, Stacey; Pyke-Grimm, Kim; Woodman, Catherine; Joffe, Steven

    2016-06-01

    Shortages of life-saving chemotherapy and supportive care agents for children with cancer are frequent. These shortages directly affect patients' lives, compromise both standard of care therapies and clinical research, and create substantial ethical challenges. Efforts to prevent drug shortages have yet to gain traction, and existing prioritization frameworks lack concrete guidance clinicians need when faced with difficult prioritization decisions among equally deserving children with cancer. The ethical framework proposed in this Commentary is based upon multidisciplinary expert opinion, further strengthened by an independent panel of peer consultants. The two-step allocation process includes strategies to mitigate existing shortages by minimizing waste and addresses actual prioritization across and within diseases according to a modified utilitarian model that maximizes total benefit while respecting limited constraints on differential treatment of individuals. The framework provides reasoning for explicit decision-making in the face of an actual drug shortage. Moreover, it minimizes bias that might occur when individual clinicians or institutions are forced to make bedside rationing and prioritization decisions and addresses the challenge that individual clinicians face when confronted with bedside decisions regarding allocation. Whenever possible, allocation decisions should be supported by evidence-based recommendations. "Curability," prognosis, and the incremental importance of a particular drug to a given patient's outcome are the critical factors to consider when deciding how to allocate scarce life-saving cancer drugs. PMID:26825103

  9. Case-control design as investigative approach to assessing cancer etiology: development and future perspectives.

    Science.gov (United States)

    Kocic, B; Filipovic, S; Petrovic, B; Nikolic, M

    2012-01-01

    The case-control method evolved out of analyses of series of cases. The analytic form of the case-control study can be found in the 19th century medical literature, but did not appear to be viewed as a special or distinct methodology. The first modern case-control study was the Janet Lane-Claypon's study of breast cancer in 1926, but the design was used only sporadically in medicine until 1950, when 4 published casecontrol studies linked smoking and lung cancer. These 1950s studies synthesized the essential elements of the case-control comparison, produced a conceptual shift within epidemiology, and laid the foundation for the rapid development of the case-control design in the subsequent half century. The powerful consistency of these case-control studies, and the replication of their findings in later prospective studies, promoted the general acceptance of the case-control study as a scientific tool in clinical research. Newer case-control studies have benefited from the advances in design, execution and analysis since 1950s. These advances include more rigorous selection and matching of case and control population, improved interviewing techniques, location of the design within a general framework of epidemiologic strategies for relating exposure to disease, understanding of the measures of effect, and application of increasingly sophisticated statistical procedures to findings. This review traces the development and future perspectives of the case-control design to assessing cancer etiology. With illustrations drawn primarily from the literature on its use and the value of its results to unravelling the etiology of malignant diseases, we tried to explore if the case-control approach firmly ensconced in epidemiology as investigational tool and rivals in importance the more straightforward cohort approach. PMID:23033277

  10. DNA damage among thyroid cancer and multiple cancer cases, controls, and long-lived individuals

    Energy Technology Data Exchange (ETDEWEB)

    Sigurdson, A J; Hauptmann, M; Alexander, B J; Doody, M M; Thomas, C B; Struewing, J P; Jones, I M

    2004-08-24

    Variation in the detection, signaling, and repair of DNA damage contributes to human cancer risk. To assess capacity to modulate endogenous DNA damage among radiologic technologists who had been diagnosed with breast cancer and another malignancy (breast-other; n=42), early-onset breast cancer (early-onset, age {<=} 35; n=38), thyroid cancer (n=68), long-lived cancer-free individuals (hyper-normals; n=20) and cancer-free controls (n=49) we quantified DNA damage (single strand breaks and abasic sites) in untreated lymphoblastoid cell lines using the alkaline comet assay. Komet{trademark} software provided comet tail length, % DNA in tail (tail DNA), comet distributed moment (CDM), and Olive tail moment (OTM) summarized as the geometric mean of 100 cells. Category cut-points (median and 75th percentile) were determined from the distribution among controls. Tail length (for {>=} 75% vs. below the median, age adjusted) was most consistently associated with the highest odds ratios in the breast-other, early-onset, and thyroid cancer groups (with risk increased 10-, 5- or 19-fold, respectively, with wide confidence intervals) and decreased risk among the hyper-normal group. For the other three Comet measures, risk of breast-other was elevated approximately three-fold. Risk of early-onset breast cancer was mixed and risk of thyroid cancer ranged from null to a two-fold increase. The hyper-normal group showed decreased odds ratios for tail DNA and OTM, but not CDM. DNA damage, as estimated by all Comet measures, was relatively unaffected by survival time, reproductive factors, and prior radiation treatment. We detected a continuum of endogenous DNA damage that was highest among cancer cases, less in controls, and suggestively lowest in hyper-normal individuals. Measuring this DNA damage phenotype may contribute to the identification of susceptible sub-groups. Our observations require replication in a prospective study with a large number of pre-diagnostic samples.

  11. ProShell – The MedAustron Accelerator Control Procedure Framework

    CERN Document Server

    Moser, R; Marchhart, M; Torcato de Matos, C; Gutleber, J; Dedič, J; Sah, S

    2011-01-01

    MedAustron is a centre for ion-therapy and research in currently under construction in Austria. It features a synchrotron particle accelerator for proton and carbon-ion beams. This paper presents the architecture and concepts for implementing a procedure framework called ProShell. Procedures to automate high level control and analysis tasks for commissioning and during operation modelled with Petri-Nets and user code is implemented with C#. It must be possible to execute procedures and monitor their execution progress remotely. Procedures include starting up devices and subsystems in a controlled manner, configuring, operating O(1000) devices and tuning their operational settings using iterative optimization algorithms. Device interfaces must be extensible to accommodate yet unanticipated functionalities. The framework implements a template for procedure specific graphical interfaces to access device specific information such as monitoring data. Procedures interact with physical devices thro...

  12. A Framework for Control System Design Subject to Average Data-Rate Constraints

    DEFF Research Database (Denmark)

    Silva, Eduardo; Derpich, Milan; Østergaard, Jan

    2011-01-01

    This paper studies discrete-time control systems subject to average data-rate limits. We focus on a situation where a noisy linear system has been designed assuming transparent feedback and, due to implementation constraints, a source-coding scheme (with unity signal transfer function) has...... to be deployed in the feedback path. For this situation, and by focusing on a class of source-coding schemes built around entropy coded dithered quantizers, we develop a framework to deal with average data-rate constraints in a tractable manner that combines ideas from both information and control theories....... As an illustration of the uses of our framework, we apply it to study the interplay between stability and average data-rates in the considered architecture. It is shown that the proposed class of coding schemes can achieve mean square stability at average data-rates that are, at most, 1.254 bits per sample away from...

  13. Development of a framework for the evaluation of the environmental benefits of controlled traffic farming

    OpenAIRE

    Mouazen, Abdul; Palmqvist, Martin

    2015-01-01

    Although controlled traffic farming (CTF) is an environmentally friendly soil management system, no quantitative evaluation of environmental benefits is available. This paper aims at establishing a framework for quantitative evaluation of the environmental benefits of CTF, considering a list of environmental benefits, namely, reducing soil compaction, runoff/erosion, energy requirement and greenhouse gas emission (GHG), conserving organic matter, enhancing soil biodiversity and fertiliser use...

  14. Dynamic Programming Principle for Stochastic Recursive Optimal Control Problem under G-framework

    OpenAIRE

    Hu, Mingshang; Ji, Shaolin

    2014-01-01

    In this paper, we study a stochastic recursive optimal control problem in which the cost functional is described by the solution of a backward stochastic differential equation driven by G-Brownian motion. Under standard assumptions, we establish the dynamic programming principle and the related fully nonlinear HJB equation in the framework of G-expectation. Finally, we show that the value function is the viscosity solution of the obtained HJB equation.

  15. A stochastic recursive optimal control problem under the G-expectation framework

    OpenAIRE

    Hu, Mingshang; Ji, Shaolin; Yang, Shuzhen

    2013-01-01

    In this paper, we study a stochastic recursive optimal control problem in which the objective functional is described by the solution of a backward stochastic differential equation driven by G-Brownian motion. Under standard assumptions, we establish the dynamic programming principle and the related Hamilton-Jacobi-Bellman (HJB) equation in the framework of G-expectation. Finally, we show that the value function is the viscosity solution of the obtained HJB equation.

  16. A framework for discussion on how to improve prevention, management, and control of hypertension in Canada.

    Science.gov (United States)

    Campbell, Norm; Young, Eric R; Drouin, Denis; Legowski, Barbara; Adams, Michael A; Farrell, Judi; Kaczorowski, Janusz; Lewanczuk, Richard; Moy Lum-Kwong, Margaret; Tobe, Sheldon

    2012-05-01

    Increased blood pressure is a leading risk for premature death and disability. The causes of increased blood pressure are intuitive and well known. However, the fundamental basis and means for improving blood pressure control are highly integrated into our complex societal structure both inside and outside our health system and hence require a comprehensive discussion of the pathway forward. A group of Canadian experts was appointed by Hypertension Canada with funding from Public Health Agency of Canada and the Heart and Stroke Foundation of Canada, Canadian Institute for Health Research (HSFC-CIHR) Chair in Hypertension Prevention and Control to draft a discussion Framework for prevention and control of hypertension. The report includes an environmental scan of past and current activities, proposals for key indicators, and targets to be achieved by 2020, and what changes are likely to be required in Canada to achieve the proposed targets. The key targets are to reduce the prevalence of hypertension to 13% of adults and improve control to 78% of those with hypertension. Broad changes in government policy, research, and health services delivery are required for these changes to occur. The Hypertension Framework process is designed to have 3 phases. The first includes the experts' report which is summarized in this report. The second phase is to gather input and priorities for action from individuals and organizations for revision of the Framework. It is hoped the Framework will stimulate discussion and input for its full intended lifespan 2011-2020. The third phase is to work with individuals and organizations on the priorities set in phase 2.

  17. Imparting biomolecules to a metal-organic framework material by controlled DNA tetrahedron encapsulation

    OpenAIRE

    Yongmei Jia; Benmei Wei; Ruixue Duan; Ying Zhang; Boya Wang; Abdul Hakeem; Nannan Liu; Xiaowen Ou; Shaofang Xu; Zhifei Chen; Xiaoding Lou; Fan Xia

    2014-01-01

    Recently, the incorporation of biomolecules in Metal-organic frameworks (MOFs) attracts many attentions because of controlling the functions, properties and stability of trapped molecules. Although there are few reports on protein/MOFs composites and their applications, none of DNA/MOFs composite is reported, as far as we know. Here, we report a new composite material which is self-assembled from 3D DNA (guest) and pre-synthesized MOFs (host) by electrostatic interactions and hydrophilic inte...

  18. Development of a Framework for the Evaluation of the Environmental Benefits of Controlled Traffic Farming

    OpenAIRE

    Abdul Mounem Mouazen; Martin Palmqvist

    2015-01-01

    Although controlled traffic farming (CTF) is an environmentally friendly soil management system, no quantitative evaluation of environmental benefits is available. This paper aims at establishing a framework for quantitative evaluation of the environmental benefits of CTF, considering a list of environmental benefits, namely, reducing soil compaction, runoff/erosion, energy requirement and greenhouse gas emission (GHG), conserving organic matter, enhancing soil biodiversity and fertiliser us...

  19. Inducing stable reversion to achieve cancer control.

    Science.gov (United States)

    Powers, Scott; Pollack, Robert E

    2016-04-01

    How can we stop cancer progression? Current strategies depend on modelling progression as the balanced outcome of mutations in, and expression of, tumour suppressor genes and oncogenes. New treatments emerge from successful attempts to tip that balance, but secondary mutational escape from those treatments has become a major impediment because it leads to resistance. In this Opinion article, we argue for a return to an earlier stratagem: tumour cell reversion. Treatments based on selection and analysis of stable revertants could create more durable remissions by reducing the selective pressure that leads to rapid drug resistance. PMID:27458638

  20. Target Diagnostic Instrument-Based Controls Framework for the National Ignition Facility (NIF)

    Energy Technology Data Exchange (ETDEWEB)

    Shelton, R T; O' Brien, D W; Kamperschroer, J H; Nelson, J R

    2007-10-03

    The extreme physics of targets shocked by NIF's 192-beam laser are observed by a diverse suite of diagnostics including optical backscatter, time-integrated and gated X-ray sensors, and laser velocity interferometry. Diagnostics to diagnose fusion ignition implosion and neutron emissions are being planned. Many diagnostics will be developed by collaborators at other sites, but ad hoc controls could lead to unreliable and costly operations. An instrument-based controls (I-BC) framework for both hardware and software facilitates development and eases integration. Each complex diagnostic typically uses an ensemble of electronic instruments attached to sensors, digitizers, cameras, and other devices. In the I-BC architecture each instrument is interfaced to a low-cost Windows XP processor and Java application. Each instrument is aggregated with others as needed in the supervisory system to form an integrated diagnostic. The Java framework provides data management, control services and operator GUI generation. I-BCs are reusable by replication and reconfiguration for specific diagnostics in XML. Advantages include minimal application code, easy testing, and better reliability. Collaborators save costs by assembling diagnostics with existing I-BCs. This paper discusses target diagnostic instrumentation used on NIF and presents the I-BC architecture and framework.

  1. What controls PTEN and what it controls (in prostate cancer)

    Institute of Scientific and Technical Information of China (English)

    Paramita M Ghosh

    2012-01-01

    The standard of care for metastatic prostate cancer (PCa) is androgen deprivation therapy since almost all PCa growth is initially reliant on the androgen receptor (AR).However,almost all patients develop resistance to this therapy within 18-24months,and current treatment for castration-resistant prostate cancer (CRPC) is extremely limited,despite the advent of new drugs that target the AR,such as ahiraterone and MDV3100.1 Multiple studies have associated the loss of phosphatase and tensin homolog deleted on chromosome 10(PTEN),a dual lipid and protein phosphatase that is frequently lost in prostate cancer,with the development of CRPC.2,3 Yet,multiple studies have shown that at least 20%-40%of primary PCa,which are almost always androgen sensitive,experience a loss of PTEN,4,5 while as many as 30% of CRPC tumors are PTEN-positive.6 The broad questions then facing researchers are:(i) How does PTEN loss cause CRPC?;(ii) What is the mechanism of CRPC development in PTEN+/+ tumors?;and (iii) How can CRPC tumors be inhibited in PTEN-null cells?Three new publications in recent times have come up with mechanisms that answer these questions.7-9 Two of these,both in Cancer Cell eadier this year,from the laboratories of Dr Charles Sawyers and Dr Hong Wu,address a novel negative feedback regulation between AR and PTEN,and all three,including the one from Dr Damu Tang,show that the loss of PTEN function is likely the first step towards the development of CRPC.

  2. Mammographic density and breast cancer: a comparison of related and unrelated controls in the Breast Cancer Family Registry

    OpenAIRE

    Linton, Linda; Martin, Lisa J.; Li, Qing; Huszti, Ella; Minkin, Salomon; John, Esther M.; Rommens, Johanna; Paterson, Andrew D.; Boyd, Norman F

    2013-01-01

    Introduction Percent mammographic density (PMD) is a strong and highly heritable risk factor for breast cancer. Studies of the role of PMD in familial breast cancer may require controls, such as the sisters of cases, selected from the same 'risk set' as the cases. The use of sister controls would allow control for factors that have been shown to influence risk of breast cancer such as race/ethnicity, socioeconomic status and a family history of breast cancer, but may introduce 'overmatching' ...

  3. Cancer and polluted work places: a case-control study.

    Science.gov (United States)

    Kjuus, H; Lislerud, A; Lyngdal, P T; Omland, H; Stave, O; Langård, S

    1982-02-01

    The possible association between selected cancers and polluted work places has been studied in a hospital-based, case-control study. By dividing all jobs in the participants working career into "polluted" and "clean", a crude measure for the total industrial exposure a worker experiences throughout his life was established. Among 103 age-matched, case-control pairs the overall estimated relative risk (RR) for exposed subjects (greater than or equal to 10 years in a polluted work place) of developing cancer compared to nonexposed (less than 10 years in a polluted work place) was 1.1. The only subgroup where a significant difference was found between the cases and the controls was the lung cancer subgroup (RR = 4.0, p = 0.02, two-tailed). When the 30 lung cancer cases were compared to an alternative control group consisting of 60 subjects matched for age and smoking habits, an estimated RR of 4.5 was found. A moderate, but not significant association between lung cancer and definite asbestos exposure was also found (RR: 2.3). As most workers are exposed to a variety of industrial agents throughout their working careers, further development of methods for characterizing combined exposures are needed, both for retrospective and prospective purposes. PMID:7068240

  4. Cyber-Physical Modeling and Control of Crowd of Pedestrians: A Review and New Framework

    CERN Document Server

    Cao, Ke-cai; Stuart, Dan; Yue, Dong

    2015-01-01

    Recent advances in modeling and control of crowds of pedestrians are briefly surveyed in this paper. Possibilities of applying fractional calculus in the modeling of crowd of pedestrians have been shortly reviewed and discussed from different aspects such as descriptions of motion, interactions of long range and effects of memory. Control of the crowd of pedestrians have also been formulated using the framework of Cyber-Physical Systems and been realized using networked Segways with onboard emergency response personnels to regulate the velocity and flux of the crowd. Platform for verification of the theoretical results are also provided in this paper.

  5. Research on framework for formation control of multiple underwater robots in a dynamic environment

    Science.gov (United States)

    Meng, Xian-Song; Xu, Hong-Gen; Zhang, Ming-Jun

    2004-12-01

    In this paper a practical framework is proposed to keep formation control of multiple underwater robots in a dynamic environment. The approach is a viable solution to solve formation problem. The approach allows online planning of the formation paths using a Dijkstra’s search algorithm based on the current sensor data. The formation is allowed to be dynamically changed in order to avoid obstacles in the environment. A controller is designed to keep the robots in their planned trajectories. It is shown that the approach is effective and feasible by the simulation of computer.

  6. On the Connection between the Hamilton-Jacobi-Bellman and the Fokker-Planck Control Frameworks

    KAUST Repository

    Annunziato, Mario

    2014-09-01

    In the framework of stochastic processes, the connection between the dynamic programming scheme given by the Hamilton-Jacobi-Bellman equation and a recently proposed control approach based on the Fokker-Planck equation is discussed. Under appropriate assumptions it is shown that the two strategies are equivalent in the case of expected cost functionals, while the FokkerPlanck formalism allows considering a larger class of objectives. To illustrate the connection between the two control strategies, the cases of an Itō stochastic process and of a piecewise-deterministic process are considered.

  7. Photochromic metal-organic frameworks: reversible control of singlet oxygen generation.

    Science.gov (United States)

    Park, Jihye; Feng, Dawei; Yuan, Shuai; Zhou, Hong-Cai

    2015-01-01

    The controlled generation of singlet oxygen is of great interest owing to its potential applications including industrial wastewater treatment, photochemistry, and photodynamic therapy. Two photochromic metal-organic frameworks, PC-PCN and SO-PCN, have been developed. A photochromic reaction has been successfully realized in PC-PCN while maintaining its single crystallinity. In particular, as a solid-state material which inherently integrates the photochromic switch and photosensitizer, SO-PCN has demonstrated reversible control of (1)O2 generation. Additionally, SO-PCN shows catalytic activity towards photooxidation of 1,5-dihydroxynaphthalene.

  8. Advancing cancer control research in an emerging news media environment.

    Science.gov (United States)

    Smith, Katherine C; Niederdeppe, Jeff; Blake, Kelly D; Cappella, Joseph N

    2013-12-01

    Cancer is both highly feared and highly newsworthy, and there is a robust body of research documenting the content and effects of cancer news coverage on health behaviors and policy. Recent years have witnessed ongoing, transformative shifts in American journalism alongside rapid advances in communication technology and the public information environment. These changes create a pressing need to consider a new set of research questions, sampling strategies, measurement techniques, and theories of media effects to ensure continued relevance and adaptation of communication research to address critical cancer control concerns. This paper begins by briefly reviewing what we know about the role of cancer news in shaping cancer-related beliefs, attitudes, behaviors, and policies. We then outline challenges and opportunities, both theoretical and methodological, posed by the rapidly changing news media environment and the nature of audience engagement. We organize our discussion around three major shifts associated with the emerging news media environment as it relates to health communication: 1) speed and dynamism of news diffusion, 2) increased narrowcasting of media content for specialized audiences, and 3) broadened participation in shaping media content. In so doing, we articulate a set of questions for future theory and research, in an effort to catalyze innovative communication scholarship to improve cancer prevention and control. PMID:24395988

  9. Intelligent Control Framework for the Feeding System in the Biomass Power Plant

    Directory of Open Access Journals (Sweden)

    Sun Jin

    2015-01-01

    Full Text Available This paper proposes an intelligent control framework for biomass drying process with flue gases based on FLC (fuzzy logic controller and CAN (Controller Area Network bus. In the operation of a biomass drying process, in order to get the biomass with the set-point low moisture content dried by waste high temperature flue gases, it is necessary to intelligent control for the biomass flow rate. Use of an experiment with varied materials at different initial moisture contents enables acquisition of the biomass flow rates as initial setting values. Set the error between actual straw moisture content and set-point, and rate of change of error as two inputs. the biomass flow rate can be acquired by the fuzzy logic computing as the output. Since the length of dryer is more than twenty meters, the integration by the CAN bus can ensure real-time reliable data acquisition and processing. The control framework for biomass drying process can be applied to a variety of biomass, such as, cotton stalk, corn stalk, rice straw, wheat straw, sugar cane. It has strong potential for practical applications because of its advantages on intelligent providing the set-point low moisture content of biomass feedstock for power generation equipment.

  10. Aqueous dispersions of oligomer-grafted carbon nanomaterials with controlled surface charge and minimal framework damage

    Science.gov (United States)

    Hu, Sheng; Chen, Shu; Menzel, Robert; Goode, Angela D.; Ryan, Mary P.; Porter, Alexandra E.; Shaffer, Milo S. P.

    2015-01-01

    Functionalised carbon nanomaterials (CNMs), with an undamaged carbon framework and controlled physiochemical properties, are desirable for a wide range of scientific studies and commercial applications. The use of a thermochemical grafting approach provides a versatile means to functionalise both multi-walled carbon nanotubes (MWCNTs) and carbon black (CB) nanoparticles without altering their inherent structure. The functionalisation process was investigated by employing various types of grafting monomers; to improve water solubility, reagents were chosen that introduced ionic character either intrinsically or after further chemical reaction. The degree of grafting for both MWCNTs and CB ranged from 3 to 27 wt%, as established by thermal gravimetric analysis (TGA). Raman spectroscopy confirmed that the structural framework of the MWNTs was unaffected by the thermochemical treatment. The effectiveness of the surface modification was demonstrated by significantly improved dispersibility and stability in water, and further quantified by zeta-potential analysis. The concentration of stable, individualised, grafted MWNTs in water ranged from 30 to 80 µg mL−1, whereas functionalised CB (CB) in water showed improved dispersibility up to ~460 µg mL−1 after centrifugation at 10, 000 g for 15 minutes. The successful preparation of structurally identical but differently functionalised nanoparticles panels, with high water compatibility and minimal framework damage, are useful for controlled experiments. For example, they can be used to explore the relationship between toxicological effects and specific physiochemical properties, such as surface charge and geometry. PMID:25254653

  11. A GPS-Based Control Framework for Accurate Current Sharing and Power Quality Improvement in Microgrids

    DEFF Research Database (Denmark)

    Golsorkhi, Mohammad; Savaghebi, Mehdi; Lu, Dylan;

    2016-01-01

    consensus protocol to ensure proportional sharing of average power. The voltage conditioning scheme produces compensation signals at fundamental and dominant harmonics to improve the voltage quality at a sensitive load bus. Experimental results are presented to validate the efficacy of the proposed method.......This paper proposes a novel hierarchical control strategy for improvement of load sharing and power quality in ac microgrids. This control framework is composed of a droop based controller at the primary level, and a combination of distributed power sharing and voltage conditioning schemes...... dynamic response. The droop coefficient, which acts as a virtual resistance is adaptively changed as a function of the peak current. This strategy not only simplifies the control design but also improves the current sharing accuracy at high loading conditions. The distributed power sharing scheme uses...

  12. An object oriented framework of EPICS for MicroTCA based control system

    International Nuclear Information System (INIS)

    EPICS (Experimental Physics and Industrial Control System) is a distributed control system platform which has been widely used for large scientific devices control like particle accelerators and fusion plant. EPICS has introduced object oriented (C++) interfaces to most of the core services. But the major part of EPICS, the run-time database, only provides C interfaces, which is hard to involve the EPICS record concerned data and routines in the object oriented architecture of the software. This paper presents an object oriented framework which contains some abstract classes to encapsulate the EPICS record concerned data and routines in C++ classes so that full OOA (Objected Oriented Analysis) and OOD (Object Oriented Design) methodologies can be used for EPICS IOC design. We also present a dynamic device management scheme for the hot swap capability of the MicroTCA based control system. (authors)

  13. A Systematic Computer-Aided Framework for Integrated Design and Control of Chemical Processes

    DEFF Research Database (Denmark)

    Mansouri, Seyed Soheil; Sales-Cruz, Mauricio; Huusom, Jakob Kjøbsted;

    Chemical processes are conventionally designed through a sequential approach. In this sequential approach, first, a steady-state process design is obtained and then, control structure synthesis that, in most of the cases, is based on heuristics is performed. Therefore, process design and process......-defined operational conditions whereas controllability is considered to maintain desired operating points of the process at any kind of imposed disturbance under normal operating conditions. In this work, a systematic hierarchical computer-aided framework for integrated process design and control of chemical...... processes including process intensification is proposed. Note however, because of integration of functions/operations into one system the controllability region of intensified equipment may become smaller (Nikačević et al., 2012). The methodology developed in this work, employs a decomposition...

  14. Hybrid Multi-Agent Control in Microgrids: Framework, Models and Implementations Based on IEC 61850

    Directory of Open Access Journals (Sweden)

    Xiaobo Dou

    2014-12-01

    Full Text Available Operation control is a vital and complex issue for microgrids. The objective of this paper is to explore the practical means of applying decentralized control by using a multi agent system in actual microgrids and devices. This paper presents a hierarchical control framework (HCF consisting of local reaction control (LRC level, local decision control (LDC level, horizontal cooperation control (HCC level and vertical cooperation control (VCC level to meet different control requirements of a microgrid. Then, a hybrid multi-agent control model (HAM is proposed to implement HCF, and the properties, functionalities and operating rules of HAM are described. Furthermore, the paper elaborates on the implementation of HAM based on the IEC 61850 Standard, and proposes some new implementation methods, such as extended information models of IEC 61850 with agent communication language and bidirectional interaction mechanism of generic object oriented substation event (GOOSE communication. A hardware design and software system are proposed and the results of simulation and laboratory tests verify the effectiveness of the proposed strategies, models and implementations.

  15. A Modular Framework for Modeling Hardware Elements in Distributed Engine Control Systems

    Science.gov (United States)

    Zinnecker, Alicia M.; Culley, Dennis E.; Aretskin-Hariton, Eliot D.

    2015-01-01

    Progress toward the implementation of distributed engine control in an aerospace application may be accelerated through the development of a hardware-in-the-loop (HIL) system for testing new control architectures and hardware outside of a physical test cell environment. One component required in an HIL simulation system is a high-fidelity model of the control platform: sensors, actuators, and the control law. The control system developed for the Commercial Modular Aero-Propulsion System Simulation 40k (C-MAPSS40k) provides a verifiable baseline for development of a model for simulating a distributed control architecture. This distributed controller model will contain enhanced hardware models, capturing the dynamics of the transducer and the effects of data processing, and a model of the controller network. A multilevel framework is presented that establishes three sets of interfaces in the control platform: communication with the engine (through sensors and actuators), communication between hardware and controller (over a network), and the physical connections within individual pieces of hardware. This introduces modularity at each level of the model, encouraging collaboration in the development and testing of various control schemes or hardware designs. At the hardware level, this modularity is leveraged through the creation of a SimulinkR library containing blocks for constructing smart transducer models complying with the IEEE 1451 specification. These hardware models were incorporated in a distributed version of the baseline C-MAPSS40k controller and simulations were run to compare the performance of the two models. The overall tracking ability differed only due to quantization effects in the feedback measurements in the distributed controller. Additionally, it was also found that the added complexity of the smart transducer models did not prevent real-time operation of the distributed controller model, a requirement of an HIL system.

  16. Risk Control of Offshore Installations. A Framework for the Establishment of Risk Indicators

    Energy Technology Data Exchange (ETDEWEB)

    Oeien, Knut

    2001-07-01

    Currently quantitative risk assessments are carried out to analyze the risk level of offshore installations and to evaluate whether or not the risk level is acceptable. By way of the quantitative risk analysis the risk status of a given installation is obtained. However, the risk status is obtained so infrequently that it is inadequate for risk control. It can be compared to economic control having the economic status presented about each fifth year, which is obviously inadequate. It is important to know the risk status because this may provide an early warning about the need for remedial actions. Without frequent information about the risk status, control of risk cannot be claimed. The main objective of this thesis has been the development of a framework for the establishment of risk indicators. These risk indicators provide a status of the risk level through measuring of changes in technical, operational and organizational factors important to risk, and is thus a means to control risk during operation of offshore petroleum installations. The framework consists of a technical methodology using the quantitative risk assessment as a basis, an organizational model, and an organizational quantification methodology. Technical risk indicators are established from the technical methodology covering the risk factors explicitly included in the quantitative risk assessment. Organizational risk indicators measure changes in the organizational risk factors included in the organizational model, but not included in the quantitative risk assessment. The organizational model is an extension to the risk model in the quantitative risk assessment. The organizational quantification methodology calculates the effect of the changes measured by the organizational risk indicators. The organizational model may also be applied as a qualitative tool for root cause analysis of incidents (process leaks). Other results are an intermediate-level expert judgment procedure applicable for

  17. A real-time control framework for urban water reservoirs operation

    Science.gov (United States)

    Galelli, S.; Goedbloed, A.; Schwanenberg, D.

    2012-04-01

    Drinking water demand in urban areas is growing parallel to the worldwide urban population, and it is acquiring an increasing part of the total water consumption. Since the delivery of sufficient water volumes in urban areas represents a difficult logistic and economical problem, different metropolitan areas are evaluating the opportunity of constructing relatively small reservoirs within urban areas. Singapore, for example, is developing the so-called 'Four National Taps Strategies', which detects the maximization of water yields from local, urban catchments as one of the most important water sources. However, the peculiar location of these reservoirs can provide a certain advantage from the logistical point of view, but it can pose serious difficulties in their daily management. Urban catchments are indeed characterized by large impervious areas: this results in a change of the hydrological cycle, with decreased infiltration and groundwater recharge, and increased patterns of surface and river discharges, with higher peak flows, volumes and concentration time. Moreover, the high concentrations of nutrients and sediments characterizing urban discharges can cause further water quality problems. In this critical hydrological context, the effective operation of urban water reservoirs must rely on real-time control techniques, which can exploit hydro-meteorological information available in real-time from hydrological and nowcasting models. This work proposes a novel framework for the real-time control of combined water quality and quantity objectives in urban reservoirs. The core of this framework is a non-linear Model Predictive Control (MPC) scheme, which employs the current state of the system, the future discharges furnished by a predictive model and a further model describing the internal dynamics of the controlled sub-system to determine an optimal control sequence over a finite prediction horizon. The main advantage of this scheme stands in its reduced

  18. Deciphering the genetic regulatory code using an inverse error control coding framework.

    Energy Technology Data Exchange (ETDEWEB)

    Rintoul, Mark Daniel; May, Elebeoba Eni; Brown, William Michael; Johnston, Anna Marie; Watson, Jean-Paul

    2005-03-01

    We have found that developing a computational framework for reconstructing error control codes for engineered data and ultimately for deciphering genetic regulatory coding sequences is a challenging and uncharted area that will require advances in computational technology for exact solutions. Although exact solutions are desired, computational approaches that yield plausible solutions would be considered sufficient as a proof of concept to the feasibility of reverse engineering error control codes and the possibility of developing a quantitative model for understanding and engineering genetic regulation. Such evidence would help move the idea of reconstructing error control codes for engineered and biological systems from the high risk high payoff realm into the highly probable high payoff domain. Additionally this work will impact biological sensor development and the ability to model and ultimately develop defense mechanisms against bioagents that can be engineered to cause catastrophic damage. Understanding how biological organisms are able to communicate their genetic message efficiently in the presence of noise can improve our current communication protocols, a continuing research interest. Towards this end, project goals include: (1) Develop parameter estimation methods for n for block codes and for n, k, and m for convolutional codes. Use methods to determine error control (EC) code parameters for gene regulatory sequence. (2) Develop an evolutionary computing computational framework for near-optimal solutions to the algebraic code reconstruction problem. Method will be tested on engineered and biological sequences.

  19. A Model-based Framework for Risk Assessment in Human-Computer Controlled Systems

    Science.gov (United States)

    Hatanaka, Iwao

    2000-01-01

    The rapid growth of computer technology and innovation has played a significant role in the rise of computer automation of human tasks in modem production systems across all industries. Although the rationale for automation has been to eliminate "human error" or to relieve humans from manual repetitive tasks, various computer-related hazards and accidents have emerged as a direct result of increased system complexity attributed to computer automation. The risk assessment techniques utilized for electromechanical systems are not suitable for today's software-intensive systems or complex human-computer controlled systems. This thesis will propose a new systemic model-based framework for analyzing risk in safety-critical systems where both computers and humans are controlling safety-critical functions. A new systems accident model will be developed based upon modem systems theory and human cognitive processes to better characterize system accidents, the role of human operators, and the influence of software in its direct control of significant system functions. Better risk assessments will then be achievable through the application of this new framework to complex human-computer controlled systems.

  20. Identifying important breast cancer control strategies in Asia, Latin America and the Middle East/North Africa

    Directory of Open Access Journals (Sweden)

    Niessen Louis W

    2011-09-01

    Full Text Available Abstract Background Breast cancer is the most frequent cause of cancer death in women worldwide, but global disparities in breast cancer control persist, due to a lack of a comprehensive breast cancer control strategy in many countries. Objectives To identify and compare the need for breast cancer control strategies in Asia, Latin America and the Middle East/North Africa and to develop a common framework to guide the development of national breast cancer control strategies. Methods Data were derived from open-ended, semi-structured interviews conducted in 2007 with 221 clinicians, policy makers, and patient advocates; stratified across Asia (n = 97, Latin America (n = 46, the Middle East/North Africa (ME/NA (n = 39 and Australia and Canada (n = 39. Respondents were identified using purposive and snowballing sampling. Interpretation of the data utilized interpretive phenomenological analysis where transcripts and field notes were coded and analyzed and common themes were identified. Analysis of regional variation was conducted based on the frequency of discussion and the writing of the manuscript followed the RATS guidelines. Results Analysis revealed four major themes that form the foundation for developing national breast cancer control strategies: 1 building capacity; 2 developing evidence; 3 removing barriers; and 4 promoting advocacy - each specified across five sub-ordinate dimensions. The propensity to discuss most dimensions was similar across regions, but managing advocacy was discussed more frequently (p = 0.004 and organized advocacy was discussed less frequently (p Conclusions This unique research identified common themes for the development of breast cancer control strategies, grounded in the experience of local practitioners, policy makers and advocacy leaders across diverse regions. Future research should be aimed at gathering a wider array of experiences, including those of patients.

  1. Serum estrogen levels and prostate cancer risk in the prostate cancer prevention trial: a nested case–control study

    OpenAIRE

    Yao, Song; Till, Cathee; Kristal, Alan R.; Goodman, Phyllis J.; Hsing, Ann W.; Tangen, Catherine M.; Platz, Elizabeth A.; Stanczyk, Frank Z.; Reichardt, Juergen K. V.; Tang, Li; Neuhouser, Marian L; Santella, Regina M.; William D Figg; Price, Douglas K.; Parnes, Howard L.

    2011-01-01

    Objective Finasteride reduces prostate cancer risk by blocking the conversion of testosterone to dihydrotestosterone. However, whether finasteride affects estrogens levels or change in estrogens affects prostate cancer risk is unknown. Methods These questions were investigated in a case–control study nested within the prostate cancer prevention trial (PCPT) with 1,798 biopsy-proven prostate cancer cases and 1,798 matched controls. Results Among men on placebo, no relationship of serum estroge...

  2. Challenges in breast and cervical cancer control in Japan.

    Science.gov (United States)

    Sauvaget, Catherine; Nishino, Yoshikazu; Konno, Ryo; Tase, Toru; Morimoto, Tadaoki; Hisamichi, Shigeru

    2016-07-01

    Since the mid-1990s, there has been an increasing incidence of, and mortality from, cervical and breast cancers in Japan. Such an increase has raised concerns over the efficiency of Japan's screening programmes for these cancers. Although citizens benefit from universal health coverage, the Japanese health insurance system mostly focuses on tertiary prevention and disease treatment, while secondary prevention (screening) is low priority. Citizens have multiple opportunities to be screened for cancer-either through programmes organised by municipalities, or individual or collective, opportunistic and comprehensive health check-ups on a voluntary basis. Despite this, however, participation is as low as 35% of the target population for both cancers. In this Policy Review, we discuss the challenges in the prevention of breast and cervical cancers in Japan, particularly focusing on the structure of the National Health Insurance system and the National Cancer Control Plan, reasons for low participation as a result of social and political attitudes, as well as providing recommendations to overcome these challenges. Japanese women would benefit from new measures to increase participation, a national data surveillance programme to monitor screening activities, and the implementation of a quality assurance system among all providers. PMID:27396648

  3. A modeling framework for deteriorating control system and predictive maintenance of actuators

    International Nuclear Information System (INIS)

    Actuators play a central role in industrial automation systems. They are costly, and therefore studying their dependability needs all attention. Usually, an actuator is inserted in a feedback control system, and its mission is to implement a control action delivered by a controller. In this paper, a monotonic actuator deterioration is considered and it is assumed that a relationship exists between the control action and the physical actuator's deterioration. A modeling framework is proposed including a non-decreasing stochastic degradation process driving the inability for an actuator to fully implement its role. The prognosis of the actuator's residual useful lifetime is derived and used to update the controller's setting. The controller reconfiguration completes the maintenance corrective and preventive actions. This new action is suggested as an alternative for maintenance strategy. - Highlights: • A degrading control system model is proposed focusing on actuator deterioration. • It is assumed a relationship between this degradation and its loss of efficiency. • The actuator RUL is quantified as a quantile of its conditional survival function. • RUL prognosis is used to reconfigure the control input law. • This new action is suggested as an alternative for maintenance strategy

  4. Oral and Pharyngeal Cancer Control and Early Detection

    OpenAIRE

    Silverman, Sol; Kerr, A. Ross; Epstein, Joel B.

    2010-01-01

    Sixty-four standardized continuing education courses were given for dentists throughout the ten public health districts of the USA to determine if certain behaviors regarding oral and pharyngeal cancer (OPC) control could be modified. Questionnaires were obtained at baseline and at 6 months along with matched control groups. One thousand eight hundred two general dentists participated at baseline and 988 at a 6-month questionnaire follow-up. Analysis of the data indicated that continuing educ...

  5. REPRODUCTIVE FACTORS AND COLORECTAL CANCER RISK. Case - control study.

    Directory of Open Access Journals (Sweden)

    Adriana Ruseva

    2015-02-01

    Full Text Available Colorectal cancer is one of the most common cancers worldwide. The role of the female sex hormones in the etiology of the disease is very intriguing. Reproductive factors are surrogate measure of lifetime exposition to the sex hormones. Purpose: Our aim is to investigate the association between the reproductive factors and colorectal carcinoma risk. Materials and methods: We include 234 Bulgarian women in our study – 117 cases with colorectal cancer and the same number of healthy controls. Cases are divided into three groups according to the localization of the tumor. We conduct case-control study, using questionnaires about reproductive factors. We use the following statistical methods – descriptive, variational analysis, binary logistic regression. Results: We observed that only the age at menopause is associated with colorectal cancer risk, and this factor has strongest protective effect in the proximal colon (95% CI - 0,051-0,781, OR – 0,200, p – 0,021. Conclusion: Analyzing our data we observed that among Bulgarian women the only reproductive factor that show association with the risk of colorectal cancer is the age at menopause.

  6. [Making Decisions on the Resources for Cancer Control

    Science.gov (United States)

    Gróf, Agnes

    2000-12-01

    We aim at modelling the strategic decision making process in case of devoting resources to a governmental cancer control program. We use a model based on the theory of Analytic Hierarchy Process. In this article we describe the characteristic features of such a decision making process and reveal the complexity of the problem underlying the decisions. A second article will present and discuss the results from the application of the AHP model. Interventions which are capable of decreasing the burden of cancer in a society need strategic approach. Decisions on interventions seem inevitable to be based on and balance between the priorities and the available resources. There is not much doubt about it that the reason for setting the priorities arises on the one hand from the scarcity of resources. On the other hand, priorities evolve on other bases, and are supposed to "guide" health policy makers devoting the scarce resources. In general, a strategic mode of thought has been based on assumptions, which, in case of cancer control enhance the necessity to assess information on cancer and cancer patients, and to understand the factors contributing towards better health. The capabilities of the NCCP achieving its aims by preventing the development of cancer diseases (primary prevention), by making use of the means of early detection and appropriate therapy (secondary prevention), and by providing modern (comprehensive) tertiary prevention are inevitably affected by the priorities. Health policy should assume a responsibility for enforcing certain priorities and should be aware of the long-term interest of the population. To solve the problem we restrict the model to a simple three level one, representing the goals, the criteria, and the alternatives of the resource allocation. We determine "decreasing the burden of cancer" as the overall goal. "Distributive justice" "cost-effectiveness", "human rights", "evidences", and "standpoints of a community" serve as criteria, while

  7. TWO OPTIMAL CONTROL PROBLEMS IN CANCER CHEMOTHERAPY WITH DRUG RESISTANCE

    Directory of Open Access Journals (Sweden)

    Werner Krabs

    2012-01-01

    Full Text Available We investigate two well-known basic optimal control problems forchemotherapeutic cancer treatment modified by introducing a timedependent “resistance factor”. This factor should be responsible for the effect of the drug resistance of tumor cells on the dynamical growth for the tumor. Both optimal control problems have common pointwise but different integral constraints on the control. We show that in both models the usually practised bang-bang control is optimal if the resistance is sufficiently strong. Further, we discuss different optimal strategies in both models for general resistance.

  8. Spatial analysis of childhood cancer: a case/control study.

    Directory of Open Access Journals (Sweden)

    Rebeca Ramis

    Full Text Available Childhood cancer was the leading cause of death among children aged 1-14 years for 2012 in Spain. Leukemia has the highest incidence, followed by tumors of the central nervous system (CNS and lymphomas (Hodgkin lymphoma, HL, and Non-Hodgkin's lymphoma, NHL. Spatial distribution of childhood cancer cases has been under concern with the aim of identifying potential risk factors.The two objectives are to study overall spatial clustering and cluster detection of cases of the three main childhood cancer causes, looking to increase etiological knowledge.We ran a case-control study. The cases were children aged 0 to 14 diagnosed with leukemia, lymphomas (HL and NHL or CNS neoplasm in five Spanish regions for the period 1996-2011. As a control group, we used a sample from the Birth Registry matching every case by year of birth, autonomous region of residence and sex with six controls. We geocoded and validated the address of the cases and controls. For our two objectives we used two different methodologies. For the first, for overall spatial clustering detection, we used the differences of K functions from the spatial point patterns perspective proposed by Diggle and Chetwynd and the second, for cluster detection, we used the spatial scan statistic proposed by Kulldorff with a level for statistical significance of 0.05.We had 1062 cases of leukemia, 714 cases of CNS, 92 of HL and 246 of NHL. Accordingly we had 6 times the number of controls, 6372 controls for leukemia, 4284 controls for CNS, 552 controls for HL and 1476 controls for NHL. We found variations in the estimated empirical D(s for the different regions and cancers, including some overall spatial clustering for specific regions and distances. We did not find statistically significant clusters.The variations in the estimated empirical D(s for the different regions and cancers could be partially explained by the differences in the spatial distribution of the population; however, according to the

  9. Meta-Analysis of a Multi-Ethnic, Breast Cancer Case-Control Targeted Sequencing Study

    OpenAIRE

    Ablorh, Akweley

    2015-01-01

    Breast cancer, the most commonly diagnosed cancer in American women, is a heritable disease with nearly one hundred known genetic risk factors. Using next generation sequencing, we explored the contribution of genetics at 12 GWAS-identified loci to breast cancer susceptibility in a multi-ethnic breast cancer case-control study. Methods: The study population consists of 4,611 breast cancer cases and controls (2,316 cases and 2,295 controls) from four mutually exclusive ethnicities: Africa...

  10. Controlling wheelchairs by body motions: A learning framework for the adaptive remapping of space

    CERN Document Server

    Gulrez, Tauseef; Fishbach, Alon; Acosta, Santiago; Scharver, Christopher; De Rossi, Danilo; Mussa-Ivaldi, Ferdinando A

    2011-01-01

    Learning to operate a vehicle is generally accomplished by forming a new cognitive map between the body motions and extrapersonal space. Here, we consider the challenge of remapping movement-to-space representations in survivors of spinal cord injury, for the control of powered wheelchairs. Our goal is to facilitate this remapping by developing interfaces between residual body motions and navigational commands that exploit the degrees of freedom that disabled individuals are most capable to coordinate. We present a new framework for allowing spinal cord injured persons to control powered wheelchairs through signals derived from their residual mobility. The main novelty of this approach lies in substituting the more common joystick controllers of powered wheelchairs with a sensor shirt. This allows the whole upper body of the user to operate as an adaptive joystick. Considerations about learning and risks have lead us to develop a safe testing environment in 3D Virtual Reality. A Personal Augmented Reality Imm...

  11. Advanced concept for damage control : A framework to simulate fire propagation and damage control effects

    NARCIS (Netherlands)

    Gillis, M.P.W.; Keijer, W.; Smit, C.S.

    2003-01-01

    Current damage control procedures are developed on the basis of a long-standing experience. However there are reasons to believe that these procedures do not account for major weapon-induced calamities. Fire fighting after substantial blast and fragmentation damage, due to a weaponhit, is quite beyo

  12. A framework to prevent and control tobacco among adolescents and children: introducing the IMPACT model.

    Science.gov (United States)

    Arora, Monika; Mathur, Manu Raj; Singh, Neha

    2013-03-01

    The objective of this paper is to provide a comprehensive evidence based model aimed at addressing multi-level risk factors influencing tobacco use among children and adolescents with multi-level policy and programmatic approaches in India. Evidences around effectiveness of policy and program interventions from developed and developing countries were reviewed using Pubmed, Scopus, Google Scholar and Ovid databases. This evidence was then categorized under three broad approaches: Policy level approaches (increased taxation on tobacco products, smoke-free laws in public places and work places, effective health warnings, prohibiting tobacco advertising, promotions and sponsorships, and restricting access to minors); Community level approaches (school health programs, mass media campaigns, community based interventions, promoting tobacco free norms) and Individual level approaches (promoting cessation in various settings). This review of literature around determinants and interventions was organized into developing the IMPACT framework. The paper further presents a comparative analysis of tobacco control interventions in India vis a vis the proposed approaches. Mixed results were found for prevention and control efforts targeting youth. However, this article suggests a number of intervention strategies that have shown to be effective. Implementing these interventions in a coordinated way will provide potential synergies across interventions. Pediatricians have prominent role in advocating and implementing the IMPACT framework in countries aiming to prevent and control tobacco use among adolescents and children.

  13. Command and Control application framework for interoperable heterogeneous ITER Remote Handling devices

    International Nuclear Information System (INIS)

    The ITER divertor Remote Handling maintenance concepts are under investigation at a full scale mockup facility, the Divertor Test Platform, located in Tampere, Finland. The key devices to carry out these operations are the (CMM), Cassette Toroidal Mover, Multi Axis Manipulators (MAM) and related tooling. Despite their differences, in essence all of these devices are manipulators with varying specifications. Hence, from the operator's point of view, they perform similar operations, such as following predefined position trajectories and lifting and carrying tools and equipment. This paper explores how to implement a software framework for a Command and Control application, otherwise known as Human Machine Interface (HMI), in such a way that it could be used to control different manipulators. A framework is presented that supports the combining of small, independent modules into a single cohesive HMI. It is then shown that a HMI can be built by combining modules that are common to these manipulators and modules that are specific to a single manipulator. This will not only minimize the programming effort but also reduce the training required of operators. To elaborate on the concept, an example HMI is implemented to control virtual models of CMM and MAM.

  14. Framework of Lower-Limb Musculoskeletal Modeling for FES Control System Development

    Directory of Open Access Journals (Sweden)

    M.K.I Ahmad

    2015-10-01

    Full Text Available In recent years, the demand of interest in functional electrical stimulation (FES is increasing due to the applications especially on spinal cord injury (SCI patients. Numerous studies have been done to regain mobility function and for health benefits especially due to FES control development for the paralyzed person. In this paper, the existing general framework modeling methods have been reviewed and the new modeling framework approach has been discussed. In general modeling and simulation can greatly facilitate to test and tune various FES control strategies. In fact, the modeling of musculoskeletal properties in people with SCI is significantly challenging for researchers due to the complexity of the system. The complexities are due to the complex structural anatomy, complicated movement and dynamics, as well as indeterminate muscle function. Although there are some models have been developed, the complexities of the system resulting mathematical representation that have a large number of parameters which make the model identification process even more difficult. Therefore, a new approach of modeling has been presented which is comparatively less burdened compared with mathematical representations. Hence this musculoskeletal model can be used for FES control system development.

  15. A framework to prevent and control tobacco among adolescents and children: introducing the IMPACT model.

    Science.gov (United States)

    Arora, Monika; Mathur, Manu Raj; Singh, Neha

    2013-03-01

    The objective of this paper is to provide a comprehensive evidence based model aimed at addressing multi-level risk factors influencing tobacco use among children and adolescents with multi-level policy and programmatic approaches in India. Evidences around effectiveness of policy and program interventions from developed and developing countries were reviewed using Pubmed, Scopus, Google Scholar and Ovid databases. This evidence was then categorized under three broad approaches: Policy level approaches (increased taxation on tobacco products, smoke-free laws in public places and work places, effective health warnings, prohibiting tobacco advertising, promotions and sponsorships, and restricting access to minors); Community level approaches (school health programs, mass media campaigns, community based interventions, promoting tobacco free norms) and Individual level approaches (promoting cessation in various settings). This review of literature around determinants and interventions was organized into developing the IMPACT framework. The paper further presents a comparative analysis of tobacco control interventions in India vis a vis the proposed approaches. Mixed results were found for prevention and control efforts targeting youth. However, this article suggests a number of intervention strategies that have shown to be effective. Implementing these interventions in a coordinated way will provide potential synergies across interventions. Pediatricians have prominent role in advocating and implementing the IMPACT framework in countries aiming to prevent and control tobacco use among adolescents and children. PMID:22592283

  16. STAR Online Framework: from Metadata Collection to Event Analysis and System Control

    Science.gov (United States)

    Arkhipkin, D.; Lauret, J.

    2015-05-01

    In preparation for the new era of RHIC running (RHIC-II upgrades and possibly, the eRHIC era), the STAR experiment is expanding its modular Message Interface and Reliable Architecture framework (MIRA). MIRA allowed STAR to integrate meta-data collection, monitoring, and online QA components in a very agile and efficient manner using a messaging infrastructure approach. In this paper, we briefly summarize our past achievements, provide an overview of the recent development activities focused on messaging patterns and describe our experience with the complex event processor (CEP) recently integrated into the MIRA framework. CEP was used in the recent RHIC Run 14, which provided practical use cases. Finally, we present our requirements and expectations for the planned expansion of our systems, which will allow our framework to acquire features typically associated with Detector Control Systems. Special attention is given to aspects related to latency, scalability and interoperability within heterogeneous set of services, various data and meta-data acquisition components coexisting in STAR online domain.

  17. A methodological framework for evaluating the evidence for Complementary and Alternative Medicine (CAM) for cancer

    DEFF Research Database (Denmark)

    Zachariae, Robert; Johannesen, Helle

    2011-01-01

    In spite of lacking evidence for effects on cancer progression itself, an increasing number of cancer patients use various types of complementary and alternative medicine (CAM). There is disagreement between CAM practitioners, researchers and clinical oncologists, as to how evidence concerning...

  18. Pain Control In Cancer Patients By Opiate Use

    Directory of Open Access Journals (Sweden)

    Mohagheghi M A

    2003-07-01

    current barriers, WHO stepwise model for cancer pain control and palliative care is recommended. Publishing Standard Treatment Guidelines for different levels of health care system is another recommended approach to optimize cancer pain."n 

  19. Control-Theoretic Framework for a Quasi-Newton Local Volatility Surface Inversion

    Science.gov (United States)

    Turinici, Gabriel

    2009-08-01

    We investigate in this paper the recovery of the local volatility surface in a parametric framework similar to that of Coleman, Li and Verma [1]. The quality of a surface is assessed through a functional which is optimized; the specificity of the approach is to separate the optimization on the parametric space (performed with any suitable optimization algorithm) from the computation of the functional where we use an adjoint formulation similar to that of the optimal control; the procedure can thus incorporate information from any derivative contract compatible with the adjoint approach. The procedure was implemented and was shown to perform satisfactory on real-world data.

  20. Control over Catenation in Metal−Organic Frameworks via Rational Design of the Organic Building Block

    Energy Technology Data Exchange (ETDEWEB)

    Farha, Omar K.; Malliakas, Christos D.; Kanatzidis, Mercouri G.; Hupp, Joseph T. (NWU)

    2010-02-19

    Metal-organic frameworks (MOFs), a hybrid class of materials comprising inorganic nodes and organic struts, have potential application in many areas due to their high surface areas and uniform pores and channels. One of the key challenges to be overcome in MOF synthesis is the strong propensity for catenation (growth of multiple independent networks within a given crystal), as catenation reduces cavity sizes and diminishes porosity. Here we demonstrate that rational design of organic building blocks, which act as strut-impervious scaffolds, can be exploited to generate highly desired noncatenated materials in a controlled fashion.

  1. New frontiers in translational control of the cancer genome.

    Science.gov (United States)

    Truitt, Morgan L; Ruggero, Davide

    2016-04-26

    The past several years have seen dramatic leaps in our understanding of how gene expression is rewired at the translation level during tumorigenesis to support the transformed phenotype. This work has been driven by an explosion in technological advances and is revealing previously unimagined regulatory mechanisms that dictate functional expression of the cancer genome. In this Review we discuss emerging trends and exciting new discoveries that reveal how this translational circuitry contributes to specific aspects of tumorigenesis and cancer cell function, with a particular focus on recent insights into the role of translational control in the adaptive response to oncogenic stress conditions. PMID:27112207

  2. Radiotherapy and subsequent thyroid cancer in German childhood cancer survivors: a nested case–control study

    International Nuclear Information System (INIS)

    Radiotherapy is associated with a risk of subsequent neoplasms (SN) in childhood cancer survivors. It has been shown that children’s thyroid glands are especially susceptible. The aim is to quantify the risk of a second neck neoplasm after primary cancer radiotherapy with emphasis on thyroid cancer. We performed a nested case–control study: 29 individuals, diagnosed with a solid SN in the neck region, including 17 with thyroid cancer, in 1980–2002 and 57 matched controls with single neoplasms were selected from the database of the German Childhood Cancer Registry. We investigated the risk associated with radiotherapy exposure given per body region, adjusted for chemotherapy. 16/17 (94.1 %) thyroid SN cases, 9/12 (75 %) other neck SN cases and 34/57 (59.6 %) controls received radiotherapy, with median doses of 27.8, 25 and 24 Gy, respectively. Radiotherapy exposure to the neck region increased the risk of the other neck SNs by 4.2 % (OR = 1.042/Gy (95 %-CI 0.980-1.109)) and of thyroid SN by 5.1 % (OR = 1.051/Gy (95 %-CI 0.984-1.123)), and radiotherapy to the neck or spine region increased the thyroid risk by 6.6 % (OR = 1.066/Gy (95 %-CI 1.010-1.125)). Chemotherapy was not a confounder. Exposure to other body regions was not associated with increased risk. Radiotherapy in the neck or spine region increases the risk of thyroid cancer, while neck exposure increases the risk of any other solid SN to a similar extent. Other studies showed a decreasing risk of subsequent thyroid cancer for very high doses; we cannot confirm this

  3. New approaches to pain control in patients with cancer.

    Science.gov (United States)

    Ahmedzai, S

    1997-07-01

    Pain affects most patients with malignant disease, and the prevalence of severe pain increases in the advanced stages of the condition. One in 5 patients with cancer has uncontrolled pain, even after 10 years of the use of the World Health Organization programme for cancer pain control and its 'three-step ladder' for the rational use of analgesics including morphine. Morphine has long been the 'gold standard' for the treatment of severe cancer pain. However, its side-effects, particularly sedation, cognitive impairment and myoclonus at high doses, have provoked the use of 'opioid rotation' to alternatives such as methadone and hydromorphone. The new 72-h transdermal patch for fentanyl also offers advantages of reduced side-effects and increased convenience over oral morphine. Intravenous strontium-89 and bisphosphonate therapy are effective for both short- and long-term control of metastatic bone pain. The spinal N-methyl-D-aspartate (NMDA) receptor is important in modulating the plasticity of the central nervous system and in aggravating chronic pain through the phenomenon of 'wind-up'. The NMDA antagonist ketamine, an anaesthetic, can be used at low doses for the management of refractory and neuropathic pains. Among adjuvant drugs, ketorolac has emerged as a potent non-steroidal anti-inflammatory drug. Palliative care is gaining acceptance as a new discipline in healthcare. Its strategic role is being reviewed as an adjunct to cancer therapy at all stages and its use is no longer confined to the terminal phase of disease after curative treatment has failed. Pain control and other aspects of symptom control are, therefore, viewed as an integral part of cancer management.

  4. A Framework for Flood Risk Analysis and Benefit Assessment of Flood Control Measures in Urban Areas.

    Science.gov (United States)

    Li, Chaochao; Cheng, Xiaotao; Li, Na; Du, Xiaohe; Yu, Qian; Kan, Guangyuan

    2016-01-01

    Flood risk analysis is more complex in urban areas than that in rural areas because of their closely packed buildings, different kinds of land uses, and large number of flood control works and drainage systems. The purpose of this paper is to propose a practical framework for flood risk analysis and benefit assessment of flood control measures in urban areas. Based on the concept of disaster risk triangle (hazard, vulnerability and exposure), a comprehensive analysis method and a general procedure were proposed for urban flood risk analysis. Urban Flood Simulation Model (UFSM) and Urban Flood Damage Assessment Model (UFDAM) were integrated to estimate the flood risk in the Pudong flood protection area (Shanghai, China). S-shaped functions were adopted to represent flood return period and damage (R-D) curves. The study results show that flood control works could significantly reduce the flood risk within the 66-year flood return period and the flood risk was reduced by 15.59%. However, the flood risk was only reduced by 7.06% when the flood return period exceeded 66-years. Hence, it is difficult to meet the increasing demands for flood control solely relying on structural measures. The R-D function is suitable to describe the changes of flood control capacity. This frame work can assess the flood risk reduction due to flood control measures, and provide crucial information for strategy development and planning adaptation. PMID:27527202

  5. A Framework for Flood Risk Analysis and Benefit Assessment of Flood Control Measures in Urban Areas

    Science.gov (United States)

    Li, Chaochao; Cheng, Xiaotao; Li, Na; Du, Xiaohe; Yu, Qian; Kan, Guangyuan

    2016-01-01

    Flood risk analysis is more complex in urban areas than that in rural areas because of their closely packed buildings, different kinds of land uses, and large number of flood control works and drainage systems. The purpose of this paper is to propose a practical framework for flood risk analysis and benefit assessment of flood control measures in urban areas. Based on the concept of disaster risk triangle (hazard, vulnerability and exposure), a comprehensive analysis method and a general procedure were proposed for urban flood risk analysis. Urban Flood Simulation Model (UFSM) and Urban Flood Damage Assessment Model (UFDAM) were integrated to estimate the flood risk in the Pudong flood protection area (Shanghai, China). S-shaped functions were adopted to represent flood return period and damage (R-D) curves. The study results show that flood control works could significantly reduce the flood risk within the 66-year flood return period and the flood risk was reduced by 15.59%. However, the flood risk was only reduced by 7.06% when the flood return period exceeded 66-years. Hence, it is difficult to meet the increasing demands for flood control solely relying on structural measures. The R-D function is suitable to describe the changes of flood control capacity. This frame work can assess the flood risk reduction due to flood control measures, and provide crucial information for strategy development and planning adaptation. PMID:27527202

  6. Defining Feasibility and Pilot Studies in Preparation for Randomised Controlled Trials: Development of a Conceptual Framework.

    Science.gov (United States)

    Eldridge, Sandra M; Lancaster, Gillian A; Campbell, Michael J; Thabane, Lehana; Hopewell, Sally; Coleman, Claire L; Bond, Christine M

    2016-01-01

    We describe a framework for defining pilot and feasibility studies focusing on studies conducted in preparation for a randomised controlled trial. To develop the framework, we undertook a Delphi survey; ran an open meeting at a trial methodology conference; conducted a review of definitions outside the health research context; consulted experts at an international consensus meeting; and reviewed 27 empirical pilot or feasibility studies. We initially adopted mutually exclusive definitions of pilot and feasibility studies. However, some Delphi survey respondents and the majority of open meeting attendees disagreed with the idea of mutually exclusive definitions. Their viewpoint was supported by definitions outside the health research context, the use of the terms 'pilot' and 'feasibility' in the literature, and participants at the international consensus meeting. In our framework, pilot studies are a subset of feasibility studies, rather than the two being mutually exclusive. A feasibility study asks whether something can be done, should we proceed with it, and if so, how. A pilot study asks the same questions but also has a specific design feature: in a pilot study a future study, or part of a future study, is conducted on a smaller scale. We suggest that to facilitate their identification, these studies should be clearly identified using the terms 'feasibility' or 'pilot' as appropriate. This should include feasibility studies that are largely qualitative; we found these difficult to identify in electronic searches because researchers rarely used the term 'feasibility' in the title or abstract of such studies. Investigators should also report appropriate objectives and methods related to feasibility; and give clear confirmation that their study is in preparation for a future randomised controlled trial designed to assess the effect of an intervention.

  7. Defining Feasibility and Pilot Studies in Preparation for Randomised Controlled Trials: Development of a Conceptual Framework.

    Directory of Open Access Journals (Sweden)

    Sandra M Eldridge

    Full Text Available We describe a framework for defining pilot and feasibility studies focusing on studies conducted in preparation for a randomised controlled trial. To develop the framework, we undertook a Delphi survey; ran an open meeting at a trial methodology conference; conducted a review of definitions outside the health research context; consulted experts at an international consensus meeting; and reviewed 27 empirical pilot or feasibility studies. We initially adopted mutually exclusive definitions of pilot and feasibility studies. However, some Delphi survey respondents and the majority of open meeting attendees disagreed with the idea of mutually exclusive definitions. Their viewpoint was supported by definitions outside the health research context, the use of the terms 'pilot' and 'feasibility' in the literature, and participants at the international consensus meeting. In our framework, pilot studies are a subset of feasibility studies, rather than the two being mutually exclusive. A feasibility study asks whether something can be done, should we proceed with it, and if so, how. A pilot study asks the same questions but also has a specific design feature: in a pilot study a future study, or part of a future study, is conducted on a smaller scale. We suggest that to facilitate their identification, these studies should be clearly identified using the terms 'feasibility' or 'pilot' as appropriate. This should include feasibility studies that are largely qualitative; we found these difficult to identify in electronic searches because researchers rarely used the term 'feasibility' in the title or abstract of such studies. Investigators should also report appropriate objectives and methods related to feasibility; and give clear confirmation that their study is in preparation for a future randomised controlled trial designed to assess the effect of an intervention.

  8. A Framework for Probabilistic Evaluation of Interval Management Tolerance in the Terminal Radar Control Area

    Science.gov (United States)

    Hercencia-Zapana, Heber; Herencia-Zapana, Heber; Hagen, George E.; Neogi, Natasha

    2012-01-01

    Projections of future traffic in the national airspace show that most of the hub airports and their attendant airspace will need to undergo significant redevelopment and redesign in order to accommodate any significant increase in traffic volume. Even though closely spaced parallel approaches increase throughput into a given airport, controller workload in oversubscribed metroplexes is further taxed by these approaches that require stringent monitoring in a saturated environment. The interval management (IM) concept in the TRACON area is designed to shift some of the operational burden from the control tower to the flight deck, placing the flight crew in charge of implementing the required speed changes to maintain a relative spacing interval. The interval management tolerance is a measure of the allowable deviation from the desired spacing interval for the IM aircraft (and its target aircraft). For this complex task, Formal Methods can help to ensure better design and system implementation. In this paper, we propose a probabilistic framework to quantify the uncertainty and performance associated with the major components of the IM tolerance. The analytical basis for this framework may be used to formalize both correctness and probabilistic system safety claims in a modular fashion at the algorithmic level in a way compatible with several Formal Methods tools.

  9. Bimetallic Metal-Organic Frameworks for Controlled Catalytic Graphitization of Nanoporous Carbons

    Science.gov (United States)

    Tang, Jing; Salunkhe, Rahul R.; Zhang, Huabin; Malgras, Victor; Ahamad, Tansir; Alshehri, Saad M.; Kobayashi, Naoya; Tominaka, Satoshi; Ide, Yusuke; Kim, Jung Ho; Yamauchi, Yusuke

    2016-07-01

    Single metal-organic frameworks (MOFs), constructed from the coordination between one-fold metal ions and organic linkers, show limited functionalities when used as precursors for nanoporous carbon materials. Herein, we propose to merge the advantages of zinc and cobalt metals ions into one single MOF crystal (i.e., bimetallic MOFs). The organic linkers that coordinate with cobalt ions tend to yield graphitic carbons after carbonization, unlike those bridging with zinc ions, due to the controlled catalytic graphitization by the cobalt nanoparticles. In this work, we demonstrate a feasible method to achieve nanoporous carbon materials with tailored properties, including specific surface area, pore size distribution, degree of graphitization, and content of heteroatoms. The bimetallic-MOF-derived nanoporous carbon are systematically characterized, highlighting the importance of precisely controlling the properties of the carbon materials. This can be done by finely tuning the components in the bimetallic MOF precursors, and thus designing optimal carbon materials for specific applications.

  10. An integrated software testing framework for FGA-based controllers in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Yeob; Kim, Eun Sub; Yoo, Jun Beom [Div. of Computer Science and Engineering, Konkuk University, Seoul (Korea, Republic of); Lee, Young Jun; Choi, Jong Gyun [MMIS Lab., Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-04-15

    Field-programmable gate arrays (FPGAs) have received much attention from the nuclear industry as an alternative platform to programmable logic controllers for digital instrumentation and control. The software aspect of FPGA development consists of several steps of synthesis and refinement, and also requires verification activities, such as simulations that are performed individually at each step. This study proposed an integrated software-testing framework for simulating all artifacts of the FPGA software development simultaneously and evaluating whether all artifacts work correctly using common oracle programs. This method also generates a massive number of meaningful simulation scenarios that reflect reactor shutdown logics. The experiment, which was performed on two FPGA software implementations, showed that it can dramatically save both time and costs.

  11. Cancer control and the communication innovation in South Korea: implications for cancer disparities.

    Science.gov (United States)

    Jung, Minsoo

    2013-01-01

    Over the last 10 years, the number of cancer survivors in South Korea has reached nearly one million with a survival rate of 49.4%. However, integrated supportive care for cancer survivors is lagging. One area in which the current cancer control policy needs updating is in the utilization of information and communication technology (ICT). The remarkable progress in the field of ICT over the past 10 years presents exciting new opportunities for health promotion. Recent communication innovations are conducive to the exchange of meta-information, giving rise to a new service area and transforming patients into active medical consumers. Consequently, such innovations encourage active participation in the mutual utilization and sharing of high-quality information. However, these benefits from new ICTs will almost certainly not be equally available to all, leading to so-called communication inequalities where cancer survivors from lower socioeconomic classes will likely have more limited access to the best means of making use of the health information. Therefore, most essentially, emphasis must be placed on helping cancer survivors and their caregivers utilize such advances in ICT to create a more efficient flow of health information, thereby reducing communication inequalities and expanding social support. Once we enhance access to health information and better manage the quality of information, as a matter of fact, we can expect an alleviation of the health inequalities faced by cancer survivors. PMID:23886120

  12. Metal-Organic Framework Synthesis System Based on Fuzzy Predictive Control via Network Transmission

    Directory of Open Access Journals (Sweden)

    Jui-Ho Chen

    2014-01-01

    Full Text Available The purpose of this study is to construct metal-organic framework (MOF synthesis heating systems based on fuzzy method for monitoring and automatic control. In this study, the temperature sensing module for measurements sensed values that it through a wireless ZigBee chips and wired DAQ device for real-time data transmission. Because MOF synthesis, often due to different modes of heating or heating instability caused by its nucleation and crystal growth rate, is an important influence, leading to different crystallinity, the use of fuzzy theory to predict the temperature parameter and instant heating MOF synthesis parameters can be adjusted to improve the accuracy of the system. The research system to RS-232 interface module for infrared emission control packets issued and automated control of the furnace through the infrared receiver module. This study is based on a terminal interface window of Visual Basic programming and LabView graphical diagram for control system design. Finally, this research, through a number of experiments to validate the use of fuzzy system development methods and networks, can improve the accuracy of the reaction efficiency MOF sensing and control the heating system.

  13. A rule-based verification and control framework in ATLAS Trigger-DAQ

    CERN Document Server

    Kazarov, A; Lehmann-Miotto, G; Sloper, J E; Ryabov, Yu; Computing In High Energy and Nuclear Physics

    2007-01-01

    In order to meet the requirements of ATLAS data taking, the ATLAS Trigger-DAQ system is composed of O(1000) of applications running on more than 2600 computers in a network. With such system size, s/w and h/w failures are quite often. To minimize system downtime, the Trigger-DAQ control system shall include advanced verification and diagnostics facilities. The operator should use tests and expertise of the TDAQ and detectors developers in order to diagnose and recover from errors, if possible automatically. The TDAQ control system is built as a distributed tree of controllers, where behavior of each controller is defined in a rule-based language allowing easy customization. The control system also includes verification framework which allow users to develop and configure tests for any component in the system with different levels of complexity. It can be used as a stand-alone test facility for a small detector installation, as part of the general TDAQ initialization procedure, and for diagnosing the problems ...

  14. Cost-effectiveness analysis of breast cancer control interventions in Peru

    NARCIS (Netherlands)

    Zelle, S.G.; Vidaurre, T.; Abugattas, J.E.; Manrique, J.E.; Sarria, G.; Jeronimo, J.; Seinfeld, J.N.; Lauer, J.A.; Sepulveda, C.R.; Venegas, D.; Baltussen, R.

    2013-01-01

    OBJECTIVES: In Peru, a country with constrained health resources, breast cancer control is characterized by late stage treatment and poor survival. To support breast cancer control in Peru, this study aims to determine the cost-effectiveness of different breast cancer control interventions relevant

  15. 77 FR 66469 - Breast and Cervical Cancer Early Detection and Control Advisory Committee (BCCEDCAC)

    Science.gov (United States)

    2012-11-05

    ... HUMAN SERVICES Centers for Disease Control and Prevention Breast and Cervical Cancer Early Detection and... meeting of the aforementioned committee: Name: Breast and Cervical Cancer Early Detection and Control..., regarding the early detection and control of breast and cervical cancer. The committee makes...

  16. A framework for developing an evidence-based, comprehensive tobacco control program

    Directory of Open Access Journals (Sweden)

    Shacham Galia

    2010-05-01

    Full Text Available Abstract Background Tobacco control is an area where the translation of evidence into policy would seem to be straightforward, given the wealth of epidemiological, behavioural and other types of research available. Yet, even here challenges exist. These include information overload, concealment of key (industry-funded evidence, contextualization, assessment of population impact, and the changing nature of the threat. Methods In the context of Israel's health targeting initiative, Healthy Israel 2020, we describe the steps taken to develop a comprehensive tobacco control strategy. We elaborate on the following: a scientific issues influencing the choice of tobacco control strategies; b organization of existing evidence of effectiveness of interventions into a manageable form, and c consideration of relevant philosophical and political issues. We propose a framework for developing a plan and illustrate this process with a case study in Israel. Results Broad consensus exists regarding the effectiveness of most interventions, but current recommendations differ in the emphasis they place on different strategies. Scientific challenges include integration of complex and sometimes conflicting information from authoritative sources, and lack of estimates of population impact of interventions. Philosophical and political challenges include the use of evidence-based versus innovative policymaking, the importance of individual versus governmental responsibility, and whether and how interventions should be prioritized. The proposed framework includes: 1 compilation of a list of potential interventions 2 modification of that list based on local needs and political constraints; 3 streamlining the list by categorizing interventions into broad groupings of related interventions; together these groupings form the basis of a comprehensive plan; and 4 refinement of the plan by comparing it to existing comprehensive plans. Conclusions Development of a comprehensive

  17. The Framework Convention on Tobacco Control: opportunities and issues El Convenio Marco para el Control del Tabaco: oportunidades y problemas

    Directory of Open Access Journals (Sweden)

    Kenneth E Warner

    2008-01-01

    Full Text Available The Framework Convention on Tobacco Control (FCTC, a World Health Organization sponsored global tobacco control treaty, constitutes the first major international tool with the potential to significantly reduce the global pandemic of tobacco-produced disease and death. After providing background on the prevalence of cigarette smoking and smoking attributable mortality, both at present and projected for the future, the paper then describes the FCTC and discusses its development, the barriers it has confronted, and the opportunities it offers for improving global health. Successful implementation of the provisions in the treaty could avoid literally tens of millions of premature tobacco-produced deaths over the next few decades.El Convenio Marco para el Control del Tabaco (CMCT, un tratado para el control global del tabaco patrocinado por la Organización Mundial de la Salud, constituye la primera herramienta internacional importante con el potencial de reducir significativamente la pandemia mundial de enfermedades y decesos producidos por el tabaco. Este ensayo proporciona antecedentes sobre la prevalencia de consumo de cigarrillos y sobre mortalidad atribuible a dicho consumo, tanto al presente como con proyección a futuro. Después describe el CMCT, su desarrollo, las barreras que ha confrontado y las oportunidades que ofrece para mejorar la salud global. La implementación exitosa de las disposiciones del tratado podría evitar, literalmente, decenas de millones de muertes prematuras producidas por el tabaco en las próximas décadas.

  18. Control Systems Security Center Comparison Study of Industrial Control System Standards against the Control Systems Protection Framework Cyber-Security Requirements

    Energy Technology Data Exchange (ETDEWEB)

    Robert P. Evans

    2005-09-01

    Cyber security standards, guidelines, and best practices for control systems are critical requirements that have been delineated and formally recognized by industry and government entities. Cyber security standards provide a common language within the industrial control system community, both national and international, to facilitate understanding of security awareness issues but, ultimately, they are intended to strengthen cyber security for control systems. This study and the preliminary findings outlined in this report are an initial attempt by the Control Systems Security Center (CSSC) Standard Awareness Team to better understand how existing and emerging industry standards, guidelines, and best practices address cyber security for industrial control systems. The Standard Awareness Team comprised subject matter experts in control systems and cyber security technologies and standards from several Department of Energy (DOE) National Laboratories, including Argonne National Laboratory, Idaho National Laboratory, Pacific Northwest National Laboratory, and Sandia National Laboratories. This study was conducted in two parts: a standard identification effort and a comparison analysis effort. During the standard identification effort, the Standard Awareness Team conducted a comprehensive open-source survey of existing control systems security standards, regulations, and guidelines in several of the critical infrastructure (CI) sectors, including the telecommunication, water, chemical, energy (electric power, petroleum and oil, natural gas), and transportation--rail sectors and sub-sectors. During the comparison analysis effort, the team compared the requirements contained in selected, identified, industry standards with the cyber security requirements in ''Cyber Security Protection Framework'', Version 0.9 (hereafter referred to as the ''Framework''). For each of the seven sector/sub-sectors listed above, one standard was

  19. A framework for the natural-language-perception-based creative control of unmanned ground vehicles

    Science.gov (United States)

    Ghaffari, Masoud; Liao, Xiaoqun; Hall, Ernest L.

    2004-09-01

    Mobile robots must often operate in an unstructured environment cluttered with obstacles and with many possible action paths. That is why mobile robotics problems are complex with many unanswered questions. To reach a high degree of autonomous operation, a new level of learning is required. On the one hand, promising learning theories such as the adaptive critic and creative control have been proposed, while on other hand the human brain"s processing ability has amazed and inspired researchers in the area of Unmanned Ground Vehicles but has been difficult to emulate in practice. A new direction in the fuzzy theory tries to develop a theory to deal with the perceptions conveyed by the natural language. This paper tries to combine these two fields and present a framework for autonomous robot navigation. The proposed creative controller like the adaptive critic controller has information stored in a dynamic database (DB), plus a dynamic task control center (TCC) that functions as a command center to decompose tasks into sub-tasks with different dynamic models and multi-criteria functions. The TCC module utilizes computational theory of perceptions to deal with the high levels of task planning. The authors are currently trying to implement the model on a real mobile robot and the preliminary results have been described in this paper.

  20. Cobit-Framework and process control engineering. Application of Cobit-Process documentation ME3; Cobit-Framework und die Netzleittechnik. Anwendung der Cobit-Prozessbeschreibung ME3

    Energy Technology Data Exchange (ETDEWEB)

    Bosin, Erwin [Tiwag-Netz AG, Thaur (Austria). Prozessrechner und USV

    2009-11-16

    Cobit (Control Objectives for Information and related Technology) is an internationally recognised framework which offers two approaches to facilitating the operativeness of the power system management. One is aimed at the selection of the relevant processes needed for meeting business requirements and the other at identifying possible improvements to control and steering mechanisms in the selected processes. This is documented by the selected Cobit ME3 process (''Ensure Compliance With External Requirements''). The high security level of the power system management must be maintained in this context.

  1. APPLICATIONS OF EXPERT SYSTEM TECHNOLOGY IN THE ATLAS TDAQ CONTROLS FRAMEWORK

    CERN Document Server

    Kazarov, A; The ATLAS collaboration; Lehmann, G; Magnoni, L; Murillo Garcia, R; Sloper, JE

    2010-01-01

    The ATLAS Trigger-DAQ system is composed of O(10000) of applications running ~1500 computers distributed over a network. To maximize the experiment run efficiency, the Trigger-DAQ control system includes advanced verification, diagnostics and complex dynamic error recovery tools, based on an expert system. The error recovery (ER) system is responsible for analyzing and recovering from a variety of errors, both software and hardware, without stopping the data-gathering operations. The verification framework allows users to develop and configure tests for any component in the system with different levels of complexity. It can be used as a standalone test facility during the general TDAQ initialization procedure, and for diagnosing the problems which may occur at run time. A key role in both recovery and verification frameworks is played by the rule-based expert system, which is also known as a knowledge-based system, to analyze errors and decide on appropriate recovery actions. The system is composed of a dynam...

  2. A framework for modelling the behaviour of a process control operator under stress

    International Nuclear Information System (INIS)

    This paper proposes the basis for a framework for modelling effects of stress on the behaviour of a process control plant operator. The qualitative effects of stress on the cognitive processing ability of the operator are discussed. Stress is thought to mainly decrease the reasoning ability of the operator. The operator will experience increased rigidity in problem solving and the narrowing of his attention and perceptual field. At the same time, the operator will be increasingly reluctant in admitting that wrong decisions have been committed. Furthermore, he will revert to skill-based behaviours. The direct consequence of stress on the decision making mechanism of the operator is the selection of inappropriate choice of action. A formal representation of decision errors is proposed and various techniques are suggested for representing various mechanisms for decision error making. The degree of experience possessed by the operator is also an important factor to the operator's tolerance of stress. The framework also allows the experience of the operator to be integrated into the model. Such an operator model can be linked to a plant simulator and the complete behaviour of the plant then be simulated

  3. A simulation framework for modeling tumor control probability in breast conserving therapy

    International Nuclear Information System (INIS)

    Background and purpose: Microscopic disease (MSD) left after tumorectomy is a major cause of local recurrence in breast conserving therapy (BCT). However, the effect of microscopic disease and RT dose on tumor control probability (TCP) was seldom studied quantitatively. A simulation framework was therefore constructed to explore the relationship between tumor load, radiation dose and TCP. Materials and methods: First, we modeled total disease load and microscopic spread with a pathology dataset. Then we estimated the remaining disease load after tumorectomy through surgery simulation. The Webb–Nahum TCP model was extended by clonogenic cell fraction to model the risk of local recurrence. The model parameters were estimated by fitting the simulated results to the observations in two clinical trials. Results: Higher histopathology grade has a strong correlation with larger MSD cell quantity. On average 12.5% of the MSD cells remained in the patient’s breast after surgery but varied considerably among patients (0–100%); illustrating the role of radiotherapy. A small clonogenic cell fraction was optimal in our model (one in every 2.7 * 106 cells). The mean radiosensitivity was estimated at 0.067 Gy−1 with standard deviation of 0.022 Gy−1. Conclusion: A relationship between radiation dose and TCP was established in a newly designed simulation framework with detailed disease load, surgery and radiotherapy models

  4. Graph theoretic framework based cooperative control and estimation of multiple UAVs for target tracking

    Science.gov (United States)

    Ahmed, Mousumi

    Designing the control technique for nonlinear dynamic systems is a significant challenge. Approaches to designing a nonlinear controller are studied and an extensive study on backstepping based technique is performed in this research with the purpose of tracking a moving target autonomously. Our main motivation is to explore the controller for cooperative and coordinating unmanned vehicles in a target tracking application. To start with, a general theoretical framework for target tracking is studied and a controller in three dimensional environment for a single UAV is designed. This research is primarily focused on finding a generalized method which can be applied to track almost any reference trajectory. The backstepping technique is employed to derive the controller for a simplified UAV kinematic model. This controller can compute three autopilot modes i.e. velocity, ground heading (or course angle), and flight path angle for tracking the unmanned vehicle. Numerical implementation is performed in MATLAB with the assumption of having perfect and full state information of the target to investigate the accuracy of the proposed controller. This controller is then frozen for the multi-vehicle problem. Distributed or decentralized cooperative control is discussed in the context of multi-agent systems. A consensus based cooperative control is studied; such consensus based control problem can be viewed from the algebraic graph theory concepts. The communication structure between the UAVs is represented by the dynamic graph where UAVs are represented by the nodes and the communication links are represented by the edges. The previously designed controller is augmented to account for the group to obtain consensus based on their communication. A theoretical development of the controller for the cooperative group of UAVs is presented and the simulation results for different communication topologies are shown. This research also investigates the cases where the communication

  5. 75 FR 7282 - Breast and Cervical Cancer Early Detection and Control Advisory Committee (BCCEDCAC)

    Science.gov (United States)

    2010-02-18

    ... HUMAN SERVICES Centers for Disease Control and Prevention Breast and Cervical Cancer Early Detection and... Force guidelines for breast and cervical cancer screening; Impact of the revised clinical screening recommendations for both breast and cervical cancer on the National Breast and Cervical Cancer Early...

  6. P27 in cell cycle control and cancer

    DEFF Research Database (Denmark)

    Møller, Michael Boe

    2000-01-01

    In order to survive, cells need tight control of cell cycle progression. The control mechanisms are often lost in human cancer cells. The cell cycle is driven forward by cyclin-dependent kinases (CDKs). The CDK inhibitors (CKIs) are important regulators of the CDKs. As the name implies, CKIs were....... In distinct NHL entities however, shortened survival seems to correlate with high expression of p27. For definitive assessment of the role played by p27 in lymphomagenesis, and the prognostic value of p27 in these tumors, further studies of distinct NHL entities are needed. This review addresses the function...

  7. Calibration and seasonal adjustment for matched case-control studies of vitamin D and cancer.

    Science.gov (United States)

    Gail, Mitchell H; Wu, Jincao; Wang, Molin; Yaun, Shiaw-Shyuan; Cook, Nancy R; Eliassen, A Heather; McCullough, Marjorie L; Yu, Kai; Zeleniuch-Jacquotte, Anne; Smith-Warner, Stephanie A; Ziegler, Regina G; Carroll, Raymond J

    2016-06-15

    Vitamin D measurements are influenced by seasonal variation and specific assay used. Motivated by multicenter studies of associations of vitamin D with cancer, we formulated an analytic framework for matched case-control data that accounts for seasonal variation and calibrates to a reference assay. Calibration data were obtained from controls sampled within decile strata of the uncalibrated vitamin D values. Seasonal sine-cosine series were fit to control data. Practical findings included the following: (1) failure to adjust for season and calibrate increased variance, bias, and mean square error and (2) analysis of continuous vitamin D requires a variance adjustment for variation in the calibration estimate. An advantage of the continuous linear risk model is that results are independent of the reference date for seasonal adjustment. (3) For categorical risk models, procedures based on categorizing the seasonally adjusted and calibrated vitamin D have near nominal operating characteristics; estimates of log odds ratios are not robust to choice of seasonal reference date, however. Thus, public health recommendations based on categories of vitamin D should also define the time of year to which they refer. This work supports the use of simple methods for calibration and seasonal adjustment and is informing analytic approaches for the multicenter Vitamin D Pooling Project for Breast and Colorectal Cancer. Published 2016. This article has been contributed to by US Government employees and their work is in the public domain in the USA. PMID:27133461

  8. A framework for back-up and restore under the Experimental Physics and Industrial Control System

    International Nuclear Information System (INIS)

    EPICS is a system that allows one to design and implement a controls system. At its foundation, i.e., the level closest to the devices being controlled, are autonomous computers, each called an Input/Output Controller or IOC. In EPICS, devices controlled by an IOC are represented by software entities called process variables. All devices are monitored/controlled by reading/writing values from/to their associated process variables. Under this schema, distributing processing over a number of IOCs and representing devices with process variables, there are a variety of ways one can view or group the information in the control system. Two of the more common groupings are by IOC (location) and by devices (function). Simply stated, the authors require a system capable of restoring the state of the machine, in their case the Advanced Photon Source, to a known desired state from somewhere in the past. To that end, they propose a framework which describes a system that periodically records and preserves the values of key process variables so that later on, those values can be written to the machine in an attempt to restore it to that same state. One of the more powerful notions that must be preserved in any system that solves this problem is the independence between the specification of what is monitored and the specification of what is written. In other words, grouping process variables for monitoring must be kept independent of the number of different ways to group process variables (e.g., by IOC, by device, etc.) when they are written

  9. Total antioxidant intake and prostate cancer in the Cancer of the Prostate in Sweden (CAPS) study. A case control study

    OpenAIRE

    Russnes, Kjell M; Möller, Elisabeth; Wilson, Kathryn M.; Carlsen,Monica; Blomhoff, Rune; Smeland, Sigbjørn; Adami, Hans-Olov; Grönberg, Henrik; Mucci, Lorelei A.; Bälter, Katarina

    2016-01-01

    Background The total intake of dietary antioxidants may reduce prostate cancer risk but available data are sparse and the possible role of supplements unclear. We investigated the potential association between total and dietary antioxidant intake and prostate cancer in a Swedish population. Methods We used FFQ data from 1499 cases and 1112 controls in the population based case–control study Cancer of the Prostate in Sweden (CAPS). The ferric reducing antioxidant potential (FRAP) assay was use...

  10. Modulation by Amino Acids: Toward Superior Control in the Synthesis of Zirconium Metal-Organic Frameworks.

    Science.gov (United States)

    Gutov, Oleksii V; Molina, Sonia; Escudero-Adán, Eduardo C; Shafir, Alexandr

    2016-09-12

    The synthesis of zirconium metal-organic frameworks (Zr MOFs) modulated by various amino acids, including l-proline, glycine, and l-phenylalanine, is shown to be a straightforward approach toward functional-group incorporation and particle-size control. High yields in Zr-MOF synthesis are achieved by employing 5 equivalents of the modulator at 120 °C. At lower temperatures, the method provides a series of Zr MOFs with increased particle size, including many suitable for single-crystal X-ray diffraction studies. Furthermore, amino acid modulators can be incorporated at defect sites in Zr MOFs with an amino acid/ligand ratio of up to 1:1, depending on the ligand structure and reaction conditions. The MOFs obtained through amino acid modulation exhibit an improved CO2 -capture capacity relative to nonfunctionalized materials.

  11. Project Cerberus: tobacco industry strategy to create an alternative to the Framework Convention on Tobacco Control.

    Science.gov (United States)

    Mamudu, Hadii M; Hammond, Ross; Glantz, Stanton A

    2008-09-01

    Between 1999 and 2001, British American Tobacco, Philip Morris, and Japan Tobacco International executed Project Cerberus to develop a global voluntary regulatory regime as an alternative to the Framework Convention on Tobacco Control (FCTC). They aimed to develop a global voluntary regulatory code to be overseen by an independent audit body and to focus attention on youth smoking prevention. The International Tobacco Products Marketing Standards announced in September 2001, however, did not have the independent audit body. Although the companies did not stop the FCTC, they continue to promote the International Tobacco Products Marketing Standards youth smoking prevention as an alternative to the FCTC. Public health civil society groups should help policymakers and governments understand the importance of not working with the tobacco industry. PMID:18633079

  12. A systems modelling framework for the design of integrated process control systems

    International Nuclear Information System (INIS)

    The paper describes a systems modelling methodology, called multilevel flow modelling, or MFM, which aims at describing complex production plants as designs, i.e. as systems having goals, functions and equipment realizing these functions. The modelling concepts are based on thermodynamics and lead to a system description in terms of multiple levels of interrelated mass or energy flow structures. The paper discusses as a basis for the modelling framework the general properties of artifacts or designs, characterizes the complexity of production systems and defines the MFM concepts which allow a consistent specification of goals and functions of these systems as generated in the process design. A modelling example is given and the application of the models for the design of plant control strategies is outlined. (author)

  13. A Chilling Example? Uruguay, Philip Morris International, and WHO's Framework Convention on Tobacco Control.

    Science.gov (United States)

    Russell, Andrew; Wainwright, Megan; Mamudu, Hadii

    2015-06-01

    The World Health Organization's Framework Convention on Tobacco Control (FCTC) is the first international public health treaty to address the global spread of tobacco products. Ethnographic research at the fourth meeting of the FCTC's Conference of the Parties in Uruguay highlights the role of the FCTC in recalibrating the relationship between international trade and investment agreements and those of global public health. Specifically, we chart the origins and development of the Punta del Este Declaration, tabled by Uruguay at the conference, to counter a legal request by Philip Morris International, the world's largest tobacco transnational, for arbitration by the International Centre for the Settlement of Investment Disputes over Uruguay's alleged violations of several international trade and investment treaties. We argue that medical anthropologists should give greater consideration to global health governance and diplomacy as a potential counterweight to the 'politics of resignation' associated with corporate capitalism.

  14. Imparting biomolecules to a metal-organic framework material by controlled DNA tetrahedron encapsulation.

    Science.gov (United States)

    Jia, Yongmei; Wei, Benmei; Duan, Ruixue; Zhang, Ying; Wang, Boya; Hakeem, Abdul; Liu, Nannan; Ou, Xiaowen; Xu, Shaofang; Chen, Zhifei; Lou, Xiaoding; Xia, Fan

    2014-08-04

    Recently, the incorporation of biomolecules in Metal-organic frameworks (MOFs) attracts many attentions because of controlling the functions, properties and stability of trapped molecules. Although there are few reports on protein/MOFs composites and their applications, none of DNA/MOFs composite is reported, as far as we know. Here, we report a new composite material which is self-assembled from 3D DNA (guest) and pre-synthesized MOFs (host) by electrostatic interactions and hydrophilic interactions in a well-dispersed fashion. Its biophysical characterization is well analyzed by fluorescence spectroscopy, quartz crystal microbalance (QCM) and transmission electron microscopy (TEM). This new composite material keeps 3D DNA nanostructure more stable than only 3D DNA nanostructure in DI water at room temperature, and stores amounts of genetic information. It will make DNA as a guest for MOFs and MOFs become a new platform for the development of DNA nanotechnology.

  15. Hydrogen bonding controlled catalysis of a porous organic framework containing benzimidazole moieties

    KAUST Repository

    Liu, Bing

    2014-01-01

    A microporous organic framework (JUC-Z12) was synthesized quantitatively from tetra(4-formylphenyl)methane and 3,3′-diaminobenzidine. JUC-Z12 shows high thermal stability (>400 °C), a large surface area (SBET = 750 m2 g-1), a well-defined uniform micropore distribution (1.09 nm) and high Qst for H2 (-8.1 kJ mol-1), CO2 (-29.5 kJ mol-1), and CH 4 (-22.2 kJ mol-1). It also exhibits selective catalytic activities in the Knoevenagel reaction, which is supposed to be controlled by hydrogen bonding between substrates and JUC-Z12. The JUC-Z12 catalyst can be easily isolated from the reaction mixture by simple filtration and reused with high activity. This journal is © the Partner Organisations 2014.

  16. Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: Results from three US population-based case-control studies of ovarian cancer

    Energy Technology Data Exchange (ETDEWEB)

    Whittemore, A.S.; Gong, G.; Itnyre, J. [Stanford Univ. School of Medicine, CA (United States)

    1997-03-01

    We investigate the familial risks of cancers of the breast and ovary, using data pooled from three population-based case-control studies of ovarian cancer that were conducted in the United States. We base estimates of the frequency of mutations of BRCA1 (and possibly other genes) on the reported occurrence of breast cancer and ovarian cancer in the mothers and sisters of 922 women with incident ovarian cancer (cases) and in 922 women with no history of ovarian cancer (controls). Segregation analysis and goodness-of-fit testing of genetic models suggest that rare mutations (frequency .0014; 95% confidence interval .0002-.011) account for all the observed aggregation of breast cancer and ovarian cancer in these families. The estimated risk of breast cancer by age 80 years is 73.5% in mutation carriers and 6.8% in noncarriers. The corresponding estimates for ovarian cancer are 27.8% in carriers and 1.8% in noncarriers. For cancer risk in carriers, these estimates are lower than those obtained from families selected for high cancer prevalence. The estimated proportion of all U.S. cancer diagnoses, by age 80 years, that are due to germ-line BRCA1 mutations is 3.0% for breast cancer and 4.4% for ovarian cancer. Aggregation of breast cancer and ovarian cancer was less evident in the families of 169 cases with borderline ovarian cancers than in the families of cases with invasive cancers. Familial aggregation did not differ by the ethnicity of the probands, although the number of non-White and Hispanic cases (N = 99) was sparse. 14 refs., 3 figs., 6 tabs.

  17. Control study of arterial interventional chemotherapy before radical gastrectomy for gastric cancer and simple radical gastrectomy for gastric cancer in treatment of advanced gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Bin Liu

    2016-01-01

    Objective: To analyze the differences in effect of arterial interventional chemotherapy before radical gastrectomy for gastric cancer and simple radical gastrectomy for gastric cancer in treatment of advanced gastric cancer.Methods:A total of 86 cases of patients with advanced gastric cancer treated in our hospital were selected as research subjects and randomly divided into two groups, observation group received arterial interventional chemotherapy combined with radical gastrectomy for gastric cancer, control group received simple radical gastrectomy for gastric cancer, and then differences in prognosis-associated factors, MMP and Leptin contents as well as tumor marker and telomerase activity levels of two groups were compared.Results:Serum HER-2/neu ECD level of observation group was lower than that of control group, and serum DKK-1, TS and TP levels were higher than those of control group; at each point in time after treatment, serum CA72-4 and CA50 contents of observation group were lower than those of control group; intraoperative MMP-2, MMP-7, MMP-9 and Leptin levels in gastric cancer tissue of observation group were lower than those of control group; telomerase activity value in gastric cancer tissue of observation group after treatment was lower than that of control group, and both PGⅠ positive expression rate and PGⅠ/ PGⅡ ratio were higher than those of control group.Conclusion: Arterial interventional chemotherapy before radical gastrectomy for gastric cancer can lower tumor malignancy, promote the curative effect of radical gastrectomy for gastric cancer and improve long-term prognosis.

  18. An Automatic Framework for Assessing Breast Cancer Risk Due to Various Hormone Replacement Therapies (HRT)

    DEFF Research Database (Denmark)

    Karemore, Gopal Raghunath; brandt, sami; Nielsen, Mads

    It is well known that menopausal hormone therapy increases mammographic density. Increase in breast density may relate to breast cancer risk. Several computer assisted automatic methods for assessing mammographic density have been suggested by J.W. Byng (1996), N. Karssemeijer (1998), J.M. Boone...

  19. Control of Process Operations and Monitoring of Product Qualities through Generic Model-based Framework in Crystallization Processes

    DEFF Research Database (Denmark)

    Abdul Samad, Noor Asma Fazli Bin

    to generate the necessary problem-system specific model, the necessary set point using the extended analytical CSD estimator and the response surface method (RSM) and a PAT system design including implementation of monitoring tools and control strategies in order to produce a desired product with its......A generic and systematic model-based framework for the design of a process monitoring and control system to achieve the desired crystal size distribution (CSD) and crystal shape for a wide range of crystallization processes has been developed. This framework combines a generic multi......-based framework is divided into three sections: a) the application of the generic multi-dimensional modelling framework are highlighted: i) the capability to develop and further extend a batch cooling crystallization model is illustrated through a paracetamol case study, supplemented by a sucrose crystallization...

  20. Framework of collagen type I - vasoactive vessels structuring invariant geometric attractor in cancer tissues: insight into biological magnetic field.

    Directory of Open Access Journals (Sweden)

    Jairo A Díaz

    Full Text Available In a previous research, we have described and documented self-assembly of geometric triangular chiral hexagon crystal-like complex organizations (GTCHC in human pathological tissues. This article documents and gathers insights into the magnetic field in cancer tissues and also how it generates an invariant functional geometric attractor constituted for collider partners in their entangled environment. The need to identify this hierarquic attractor was born out of the concern to understand how the vascular net of these complexes are organized, and to determine if the spiral vascular subpatterns observed adjacent to GTCHC complexes and their assembly are interrelational. The study focuses on cancer tissues and all the macroscopic and microscopic material in which GTCHC complexes are identified, which have been overlooked so far, and are rigorously revised. This revision follows the same parameters that were established in the initial phase of the investigation, but with a new item: the visualization and documentation of external dorsal serous vascular bed areas in spatial correlation with the localization of GTCHC complexes inside the tumors. Following the standard of the electro-optical collision model, we were able to reproduce and replicate collider patterns, that is, pairs of left and right hand spin-spiraled subpatterns, associated with the orientation of the spinning process that can be an expansion or contraction disposition of light particles. Agreement between this model and tumor data is surprisingly close; electromagnetic spiral patterns generated were identical at the spiral vascular arrangement in connection with GTCHC complexes in malignant tumors. These findings suggest that the framework of collagen type 1 - vasoactive vessels that structure geometric attractors in cancer tissues with invariant morphology sets generate collider partners in their magnetic domain with opposite biological behavior. If these principles are incorporated

  1. Android Security Framework: Enabling Generic and Extensible Access Control on Android

    OpenAIRE

    Backes, Michael; Bugiel, Sven; Gerling, Sebastian; von Styp-Rekowsky, Philipp

    2014-01-01

    We introduce the Android Security Framework (ASF), a generic, extensible security framework for Android that enables the development and integration of a wide spectrum of security models in form of code-based security modules. The design of ASF reflects lessons learned from the literature on established security frameworks (such as Linux Security Modules or the BSD MAC Framework) and intertwines them with the particular requirements and challenges from the design of Android's software stack. ...

  2. Cervical cancer control in Latin America: A call to action.

    Science.gov (United States)

    Bychkovsky, Brittany L; Ferreyra, Mayra E; Strasser-Weippl, Kathrin; Herold, Christina I; de Lima Lopes, Gilberto; Dizon, Don S; Schmeler, Kathleen M; Del Carmen, Marcela; Randall, Tom C; Nogueira-Rodrigues, Angelica; de Carvalho Calabrich, Aknar Freire; St Louis, Jessica; Vail, Caroline M; Goss, Paul E

    2016-02-15

    Cervical cancer (CC) is second most common cause of cancer in Latin America and is a leading cause of cancer mortality among women. In 2015, an estimated 74,488 women will be diagnosed with CC in Latin America and 31,303 will die of the disease. CC mortality is projected to increase by 45% by 2030 despite human papillomavirus (HPV) vaccination and screening efforts. In this setting, the goal was of the current study was to examine CC control efforts in Latin America and identify deficiencies in these efforts that could be addressed to reduce CC incidence and mortality. The authors found that HPV vaccination has been introduced in the majority of Latin American countries, and there is now a need to monitor the success (or shortcomings) of these programs and to ensure that these programs are sustainable. This topic was also reviewed in light of emerging data demonstrating that visual inspection with acetic acid and HPV DNA testing without Papanicolaou tests have efficacy from a screening perspective and are good alternatives to cytology-based screening programs. Overall, there is a need to build capacity for CC control in Latin America and the best strategy will depend on the country/region and must be tailored to meet the needs of the population as well as available resources.

  3. Defining feasibility and pilot studies in preparation for randomised controlled trials:development of a conceptual framework

    OpenAIRE

    Eldridge, Sandra M.; Lancaster, Gillian A.; Michael J. Campbell; Thabane, Lehana; Hopewell, Sally; Coleman, Claire L.; Bond, Christine M

    2016-01-01

    We describe a framework for defining pilot and feasibility studies focusing on studies conducted in preparation for a randomised controlled trial. To develop the framework, we undertook a Delphi survey; ran an open meeting at a trial methodology conference; conducted a review of definitions outside the health research context; consulted experts at an international consensus meeting; and reviewed 27 empirical pilot or feasibility studies. We initially adopted mutually exclusive definitions of ...

  4. Lower Breast Cancer Risk among Women following the World Cancer Research Fund and American Institute for Cancer Research Lifestyle Recommendations: EpiGEICAM Case-Control Study

    OpenAIRE

    Adela Castelló; Miguel Martín; Amparo Ruiz; Casas, Ana M.; Baena-Cañada, Jose M; Virginia Lope; Silvia Antolín; Pedro Sánchez; Manuel Ramos; Antonio Antón; Montserrat Muñoz; Begoña Bermejo; Ana De Juan-Ferré; Carlos Jara; José I Chacón

    2015-01-01

    Background According to the “World Cancer Research Fund” and the “American Institute of Cancer Research” (WCRF/AICR) one in four cancer cases could be prevented through a healthy diet, weight control and physical activity. Objective To explore the association between the WCRF/AICR recommendations and risk of breast cancer. Methods During the period 2006 to 2011 we recruited 973 incident cases of breast cancer and 973 controls from 17 Spanish Regions. We constructed a score based on 9 of the W...

  5. Guidelines for timely initiation of chemotherapy: a proposed framework for access to medical oncology and haematology cancer clinics and chemotherapy services.

    Science.gov (United States)

    Alexander, M; Beattie-Manning, R; Blum, R; Byrne, J; Hornby, C; Kearny, C; Love, N; McGlashan, J; McKiernan, S; Milar, J L; Murray, D; Opat, S; Parente, P; Thomas, J; Tweddle, N; Underhill, C; Whitfield, K; Kirsa, S; Rischin, D

    2016-08-01

    These guidelines, informed by the best available evidence and consensus expert opinion, provide a framework to guide the timely initiation of chemotherapy for treating cancer. They sit at the intersection of patient experience, state-of-the-art disease management and rational efficient service provision for these patients at a system level. Internationally, cancer waiting times are routinely measured and publicly reported. In Australia, there are existing policies and guidelines relating to the timeliness of cancer care for surgery and radiation therapy; however, until now, equivalent guidance for chemotherapy was lacking. Timeliness of care should be informed, where available, by evidence for improved patient outcomes. Independent of this, it should be recognised that shorter waiting periods are likely to reduce patient anxiety. While these guidelines were developed as part of a proposed framework for consideration by the Victorian Department of Health, they are clinically relevant to national and international cancer services. They are intended to be used by clinical and administrative staff within cancer services. Adoption of these guidelines, which are for the timely triage, review and treatment of cancer patients receiving systemic chemotherapy, aims to ensure that patients receive care within a timeframe that will maximise health outcomes, and that access to care is consistent and equitable across cancer services. Local monitoring of performance against this guideline will enable cancer service providers to manage proactively future service demand. PMID:27553996

  6. A case-control study of asthma and ovarian cancer.

    Science.gov (United States)

    Elmasri, Wafic M; Tran, Therese H; Mulla, Zuber D

    2010-01-01

    Epidemiologic studies have found inverse associations between allergy and the development of certain tumors. The authors sought to determine if there was an association between asthma and ovarian cancer. A case-control study was conducted using Florida hospital data (year 2001). Discharge diagnoses were coded using the ICD-9-CM (International Classification of Diseases, Ninth Revision, Clinical Modification). Cases were 1,582 women whose principal discharge diagnosis was a malignant neoplasm of the ovary. Two control series were used: 4,744 women whose principal diagnosis was an upper limb bone fracture, and 21,830 women whose principal diagnosis was an acute myocardial infarction. Odds ratios (ORs) adjusted for age, race-ethnicity, Medicaid status, obesity, and smoking were calculated. Cases were 30% less likely than fracture control to be asthmatics (adjusted OR = 0.70, 95% confidence interval [CI]: 0.49-0.99, p = .04). Similarly, cases when compared to acute myocardial infarction controls were significantly less likely to have asthma (adjusted OR = 0.62, 95% CI: 0.45-0.87, p = .005). The results of this statewide exploratory study suggest that individuals with asthma may have a lower risk of developing ovarian cancer than nonasthmatics. PMID:20439229

  7. Breast cancer risk associated with different HRT formulations: a register-based case-control study

    OpenAIRE

    Thai Do; Möhner Sabine; Heinemann Lothar AJ; Dinger Juergen C; Assmann Anita

    2006-01-01

    Abstract Background Previous epidemiological studies have inconsistently shown a modestly increased breast cancer risk associated with hormone replacement therapy (HRT). Limited information is available about different formulations – particularly concerning different progestins. Methods A case-control study was performed within Germany in collaboration with regional cancer registries and tumor centers. Up to 5 controls were matched breast cancer cases. Conditional logistic regression analysis...

  8. 76 FR 30723 - Breast and Cervical Cancer Early Detection and Control Advisory Committee (BCCEDCAC)

    Science.gov (United States)

    2011-05-26

    ... HUMAN SERVICES Centers for Disease Control and Prevention Breast and Cervical Cancer Early Detection and... for breast and cervical cancer screening; updates on the National Breast and Cervical Cancer Early... Health and Human Services, and the Director, CDC, regarding the early detection and control of breast...

  9. Opportunity for Collaboration: A Conceptual Model of Success in Tobacco Control and Cancer Prevention

    OpenAIRE

    Frances A Stillman; Schmitt, Carol L.; Rosas, Scott R.

    2011-01-01

    Introduction Collaborations between cancer prevention and tobacco control programs can leverage scarce resources to address noncommunicable diseases globally, but barriers to cooperation and actual collaboration are substantial. To foster collaboration between cancer prevention and tobacco control programs, the Global Health Partnership conducted research to identify similarities and differences in how the 2 programs viewed program success. Methods Using concept mapping, cancer prevention and...

  10. The relationship of uncertainty, control, commitment, and threat of recurrence to coping strategies used by women diagnosed with breast cancer.

    Science.gov (United States)

    Hilton, B A

    1989-02-01

    The purpose of this descriptive correlational study was to investigate the relationship between commitments, uncertainty about the cancer situation, threat of recurrence, and control of the cancer situation and the set of coping strategies used by women to cope with their breast cancer diagnosis. Lazarus and Folkman's theory of psychological stress provided the framework. The sample consisted of 227 nonhospitalized women who had had a diagnosis of breast cancer. Two sets of canonical variate sets were significant at the .001 level with canonical correlations of .52 and .47. The first canonical set indicated that the use of escape-avoidance and accepting responsibility but not positive reappraisal strategies were characteristics of those women who had low commitment and low control together with high uncertainty and high threat of recurrence. The second set indicated that seeking social support, as well as the use of planful problem solving, escape-avoidance, positive reappraisal, and self-controlling strategies was adopted by women who had high threat of recurrence and high control.

  11. An Automatic Framework for Assessing Breast Cancer Risk Due to Various Hormone Replacement Therapies (HRT)

    DEFF Research Database (Denmark)

    Karemore, Gopal Raghunath; Brandt, Sami; Nielsen, Mads

    measurements of breast density changes related to HRT. 2) To investigate whether transdermal low dose estradiol treatment induces changes in mammographic density compared to raloxifene and if these findings indicate elevation of breast cancer risk by treatment. Material and Methods: Digitised mammographies......Background: It is well known that Menopausal Hormone therapy increases mammographic density. Increase in breast density may relate to breast cancer risk. Several computer assisted automatic methods for assessing mammographic density have been suggested by J.W. Byng (1996), N. Karssemeijer (1998), J...... of 2x135 completers of a two year, randomised, trial formed the base of the present analysis. Active treatments were transdermal estradiol releasing 0.014mg E2/week and orally administered raloxifene hydrochloride, 60mg/day respectively. Influence of the therapies on breast density was assessed...

  12. Human resources for cancer control in uttar pradesh, India: a case study for low and middle income countries.

    Science.gov (United States)

    Daphtary, Maithili; Agrawal, Sushma; Vikram, Bhadrasain

    2014-01-01

    For addressing the growing burden of cancer in low and middle income countries, an important first step is to estimate the human resources required for cancer control in a country, province, or city. However, few guidelines are available to decision makers in that regard. Here, we propose a methodology for estimating the human and other resources needed in the state of Uttar Pradesh (UP), India as a case study. Information about the population of UP and its cities was obtained from http://citypopulation.de/. The number of new cancer cases annually for the commonest cancers was estimated from GLOBOCAN 2008. For estimating the human resources needed, the following assumptions were made: newly diagnosed cancer patients need pathology for diagnosis and for treatment surgery, chemotherapy, and/or radiotherapy. The percentage of patients requiring each of those modalities, their average lengths of stay as in-patients, and number of in-patient oncology beds were estimated. The resources already available in UP were determined by a telephone survey and by searching the websites of radiation therapy centers and medical colleges. Twenty-four radiation oncologists at 24 cancer centers in 10 cities responded to the survey. As detailed in this manuscript, an enormous shortage of human resources for cancer control exists in UP. Human resources are the key to diagnosing cancers early and treating them appropriately. Addressing the shortage will not be easy but we hope that the methodology described here can guide decision makers and form a framework for discussion among the various stakeholders. This methodology is readily adaptable to local practices and data.

  13. Change of mammographic density predicts the risk of contralateral breast cancer - a case-control study

    OpenAIRE

    Sandberg, Maria EC; Li, Jingmei; Hall, Per; Hartman, Mikael; dos-Santos-Silva, Isabel; Humphreys, Keith; Czene, Kamila

    2013-01-01

    Introduction Mammographic density is a strong risk factor for breast cancer, but it is unknown whether density at first breast cancer diagnosis and changes during follow-up influences risk of non-simultaneous contralateral breast cancer (CBC). Methods We collected mammograms for CBC-patients (cases, N = 211) and unilateral breast cancer patients (controls, N = 211), individually matched on age and calendar period of first breast cancer diagnosis, type of adjuvant therapy and length of follow-...

  14. Unified Desktop for Monitoring & Control Applications - The Open Navigator Framework Applied for Control Centre and EGSE Applications

    Science.gov (United States)

    Brauer, U.

    2007-08-01

    The Open Navigator Framework (ONF) was developed to provide a unified and scalable platform for user interface integration. The main objective for the framework was to raise usability of monitoring and control consoles and to provide a reuse of software components in different application areas. ONF is currently applied for the Columbus onboard crew interface, the commanding application for the Columbus Control Centre, the Columbus user facilities specialized user interfaces, the Mission Execution Crew Assistant (MECA) study and EADS Astrium internal R&D projects. ONF provides a well documented and proven middleware for GUI components (Java plugin interface, simplified concept similar to Eclipse). The overall application configuration is performed within a graphical user interface for layout and component selection. The end-user does not have to work in the underlying XML configuration files. ONF was optimized to provide harmonized user interfaces for monitoring and command consoles. It provides many convenience functions designed together with flight controllers and onboard crew: user defined workspaces, incl. support for multi screens efficient communication mechanism between the components integrated web browsing and documentation search &viewing consistent and integrated menus and shortcuts common logging and application configuration (properties) supervision interface for remote plugin GUI access (web based) A large number of operationally proven ONF components have been developed: Command Stack & History: Release of commands and follow up the command acknowledges System Message Panel: Browse, filter and search system messages/events Unified Synoptic System: Generic synoptic display system Situational Awareness : Show overall subsystem status based on monitoring of key parameters System Model Browser: Browse mission database defintions (measurements, commands, events) Flight Procedure Executor: Execute checklist and logical flow interactive procedures Web

  15. [Tobacco smoking and principles of the who framework convention on tobacco control: a review].

    Science.gov (United States)

    Melkadze, N

    2013-02-01

    The aim of a review is to examine the current state of the relevant publications on tobacco smoking, the Guidelines on Protection from Exposure to Tobacco Smoke, and WHO Framework Convention on Tobacco Control (FCTC), which commits countries to protect the public's health by adopting various measures to reduce demand for tobacco. Georgia ratified the treaty in February 2006. In Georgia the implementation of the WHO FCTC is regulated by the "Law on Tobacco Control" (Law). It went into effect in September 2003. Changes and additions to the Law were approved by the Parliament in December 2008 (N 941 - rs) and in December 2010 (№4059-rs). According to Article 10 of the Law, smoking is prohibited at the educational and childcare institutions, medical and pharmaceutical facilities, at the entire area of petrol, gas and gas-distribution stations, in public transport, indoor areas of work and mass gathering... In spite of the legislation rights of non-smokers are very poorly preserved. With this in mind, the Welfare Foundation, the FCTC and the Tobacco Control Alliance, organized a public discussion on enforcing smoke-free laws in Georgia, in December 2012 at Tbilisi Marriott Courtyard Hotel. In order to make public libraries, educational, cultural institutions «de jure» and «de facto» free from tobacco smoke, the campaign against tobacco, which aims to strengthen implementation of the Tobacco Control Law and Regulation should be held in public libraries - not in the hotels. It is necessary to hang a poster - «Environment free from Smoke» at the entrance to buildings where smoking is prohibited throughout. In Rules and regulations for the use of the library there must be a note: smoking is prohibited in the library. We hope that Georgia in the nearest future will be in the list of countries with smoke-free public and work places. PMID:23482366

  16. Data Quality Control of the French Permanent Broadband Network in the RESIF Framework.

    Science.gov (United States)

    Grunberg, M.; Lambotte, S.; Engels, F.

    2014-12-01

    In the framework of the RESIF (Réseau Sismologique et géodésique Français) project, a new information system is setting up, allowing the improvement of the management and the distribution of high quality data from the different elements of RESIF. Within this information system, EOST (in Strasbourg) is in charge of collecting real-time permanent broadband seismic waveform, and performing Quality Control on these data. The real-time and validated data set are pushed to the French National Distribution Center (Isterre/Grenoble) to make them publicly available. Furthermore EOST hosts the BCSF-ReNaSS, in charge of the French metropolitan seismic bulletin. This allows to benefit from some high-end quality control based on the national and world-wide seismicity. Here we present the real-time seismic data flow from the stations of the French National Broad Band Network to EOST, and then, the data Quality Control procedures that were recently installed, including some new developments.The data Quality Control consists in applying a variety of processes to check the consistency of the whole system from the stations to the data center. This allows us to verify that instruments and data transmission are operating correctly. Moreover, time quality is critical for most of the scientific data applications. To face this challenge and check the consistency of polarities and amplitudes, we deployed several high-end processes including a noise correlation procedure to check for timing accuracy (intrumental time errors result in a time-shift of the whole cross-correlation, clearly distinct from those due to change in medium physical properties), and a systematic comparison of synthetic and real data for teleseismic earthquakes of magnitude larger than 6.5 to detect timing errors as well as polarity and amplitude problems.

  17. Implementation of the Framework Convention on Tobacco Control in Africa: Current Status of Legislation

    Directory of Open Access Journals (Sweden)

    Jacqueline Tumwine

    2011-11-01

    Full Text Available Objective: To describe, as of July 2011, the status of tobacco control legislation in Africa in three key areas of the Framework Convention on Tobacco Control (FCTC—(1 Protection from exposure to tobacco smoke, (2 Packaging and labelling of tobacco products, and (3 Tobacco advertising, promotion and sponsorship. Methods: Review and analysis of tobacco control legislation in Africa, media reports, journal articles, tobacco industry documents and data published in the 2011 WHO Report on the Global Tobacco Epidemic. Results: Modest progress in FCTC implementation in Africa with many countries having legislation or policies on the protection from exposure to tobacco smoke, however, only a handful of countries meet the standards of the FCTC Article 8 and its Guidelines particularly with regards to designated smoking areas. Little progress on packaging and labelling of tobacco products, with few countries having legislation meeting the minimum standards of the FCTC Article 11 and its Guidelines. Mauritius is the only African country with graphic or pictorial health warnings in place and has the largest warning labels in Africa. Slightly better progress in banning tobacco advertising, promotion and sponsorship has been shown by African countries, although the majority of legislation falls short of the standards of the FCTC Article 13 and its Guidelines. Despite their efforts, African countries’ FCTC implementation at national level has not matched the strong regional commitment demonstrated during the FCTC treaty negotiations. Conclusion: This study highlights the need for Africa to step up efforts to adopt and implement effective tobacco control legislation that is fully compliant with the FCTC. In order to achieve this, countries should prioritise resources for capacity building for drafting strong FCTC compliant legislation, research to inform policy and boost political will, and countering the tobacco industry which is a major obstacle to FCTC

  18. Compositional control of pore geometry in multivariate metal-organic frameworks: an experimental and computational study.

    Science.gov (United States)

    Cadman, Laura K; Bristow, Jessica K; Stubbs, Naomi E; Tiana, Davide; Mahon, Mary F; Walsh, Aron; Burrows, Andrew D

    2016-03-14

    A new approach is reported for tailoring the pore geometry in five series of multivariate metal–organic frameworks (MOFs) based on the structure [Zn2(bdc)2(dabco)] (bdc = 1,4-benzenedicarboxylate, dabco = 1,8-diazabicyclooctane), DMOF-1. A doping procedure has been adopted to form series of MOFs containing varying linker ratios. The series under investigation are [Zn2(bdc)(2-x)(bdc-Br)x(dabco)]·nDMF 1 (bdc-Br = 2-bromo-1,4-benzenedicarboxylate), [Zn2(bdc)(2-x)(bdc-I)x(dabco)]·nDMF 2 (bdc-I = 2-iodo-1,4-benzenedicarboxylate), [Zn2(bdc)(2-x)(bdc-NO2)x(dabco)]·nDMF 3 (bdc-NO2 = 2-nitro-1,4-benzenedicarboxylate), [Zn2(bdc)(2-x)(bdc-NH2)x(dabco)]·nDMF 4 (bdc-NH2 = 2-amino-1,4-benzenedicarboxylate) and [Zn2(bdc-Br)(2-x)(bdc-I)x(dabco)]·nDMF 5. Series 1-3 demonstrate a functionality-dependent pore geometry transition from the square, open pores of DMOF-1 to rhomboidal, narrow pores with increasing proportion of the 2-substituted bdc linker, with the rhomboidal-pore MOFs also showing a temperature-dependent phase change. In contrast, all members of series 4 and 5 have uniform pore geometries. In series 4 this is a square pore topology, whilst series 5 exhibits the rhomboidal pore form. Computational analyses reveal that the pore size and shape in systems 1 and 2 is altered through non-covalent interactions between the organic linkers within the framework, and that this can be controlled by the ligand functionality and ratio. This approach affords the potential to tailor pore geometry and shape within MOFs through judicious choice of ligand ratios. PMID:26660286

  19. Continuous improvement of the regulatory framework for the control of medical exposure

    International Nuclear Information System (INIS)

    One of the key elements to guide the improvement of the regulatory control is the availability of a self-assessment tool for regulatory performance. Although there is general guidance on self-assessment for regulators and users (IAEA), there is a need for more specific advice on how to address challenges and difficulties faced by regulatory bodies, when regulating radiation protection of patients. Examples of these challenges are the need for regulatory initiatives, in cooperation with health and education authorities, professional bodies and equipment suppliers, and to put in place necessary elements that are beyond responsibility of individual user of radiation, to enable them compliance with safety standards. Purpose: Within the programme of the Ibero American Forum of Nuclear and Radiation Safety Regulatory Organizations, a project to develop such a self-assessment tool for the regulatory control of medical exposure has been designed. Method: National experiences in transposing and enforcing the international radiation safety standards, as to how the requirements are included in national regulations are reviewed. Further, difficulties to the implementation of safety requirements are analyzed and a self-assessment approach and possible regulatory solutions a are presented. Results and discussion: In this study the following documents are being produced: 1) transposition of international requirements into national regulations in the six countries of the Forum, 2) difficulties to implement and enforce the requirements, 3) guidance on self-assessment of regulatory framework for medical exposure, 4) suggested contribution to the revision of international radiation safety standards. (author)

  20. A Network Access Control Framework for 6LoWPAN Networks

    Directory of Open Access Journals (Sweden)

    Amaro F. de Sousa

    2013-01-01

    Full Text Available Low power over wireless personal area networks (LoWPAN, in particular wireless sensor networks, represent an emerging technology with high potential to be employed in critical situations like security surveillance, battlefields, smart-grids, and in e-health applications. The support of security services in LoWPAN is considered a challenge. First, this type of networks is usually deployed in unattended environments, making them vulnerable to security attacks. Second, the constraints inherent to LoWPAN, such as scarce resources and limited battery capacity, impose a careful planning on how and where the security services should be deployed. Besides protecting the network from some well-known threats, it is important that security mechanisms be able to withstand attacks that have not been identified before. One way of reaching this goal is to control, at the network access level, which nodes can be attached to the network and to enforce their security compliance. This paper presents a network access security framework that can be used to control the nodes that have access to the network, based on administrative approval, and to enforce security compliance to the authorized nodes.

  1. Holistic Web-based Virtual Micro Controller Framework for Research and Education

    Directory of Open Access Journals (Sweden)

    Sven Seiler

    2012-11-01

    Full Text Available Education in the field of embedded system programming became an even more important aspect in the qualification of young engineers during the last decade. This development is accompanied by a rapidly increasing complexity of the software environments used with such devices. Therefore a qualified and solid teaching methodology is necessary, accompanied by industry driven technological innovation with an emphasis on programming. As part of three European projects regarding lifelong-learning a comprehensive blended learning concept for teaching embedded systems and robotics was developed by paper authors. It comprises basic exercises in micro controller programming up to high-level student robotic challenges. These implemented measures are supported by a distance learning environment. The programming of embedded systems and microcontroller technology has to be seen as the precursor for more complex robotic systems in this context, but with a high importance for later successfully working with the technology for further professional utilization with these technologies. Current paper introduces the most novel part; the online accessible Virtual Micro Controller Platform (VMCU and its underlying simulation framework platform. This approach conquers the major existing problems in engineering education: outdated hardware and limited lab times. This paper answers the question about advantages of using virtual hardware in an educational environment.

  2. Dietary Screener Questionnaire in the National Health Interview Survey Cancer Control Supplement 2010: Overview

    Science.gov (United States)

    The National Health Interview Survey (NHIS) Cancer Control Supplement (CCS) is administered every five years and focuses on knowledge, attitudes, and practices in cancer-related health behaviors, screening, and risk assessment.

  3. Cancer Statistics

    Science.gov (United States)

    ... What Is Cancer? Cancer Statistics Cancer Disparities Cancer Statistics Cancer has a major impact on society in ... success of efforts to control and manage cancer. Statistics at a Glance: The Burden of Cancer in ...

  4. Application of the health literacy framework to diet-related cancer prevention conversations of older immigrant women to Canada.

    Science.gov (United States)

    Thomson, M D; Hoffman-Goetz, L

    2012-03-01

    Health literacy, conceptualized as a framework involving basic (functional), interactive and critical skill sets, is a key determinant of health. Application of the health literacy framework (HLF) to immigrant populations has been limited. Our objective was to apply the HLF to discourses about diet-related colon cancer prevention among English-as-a-Second-Language (ESL) immigrant women. We also explored whether these discussions could inform the development of culturally appropriate information and potentially increase health literacy. Interviews were conducted with 64 older Spanish-speaking ESL immigrant women. Directed content analysis guided by the HLF was used to identify themes. Diet-related conversations were initiated by 43 (67%) participants. Four themes were identified: general information requests-low functional health literacy (FHL) (n = 23/43), specific nutrition inquiries-high FHL (n = 17/43), actions for healthy eating-low interactive health literacy (IHL) (n = 8/43) and community communication issues-high IHL (n = 3/43). No conversations representing critical health literacy were identified. Five women discussed both FHL and IHL themes. Women's diet-related conversations followed a continuum of increasing information needs supporting the HLF. PMID:21421578

  5. Sustainability in a state comprehensive cancer control coalition: lessons learned.

    Science.gov (United States)

    Desmond, Renee A; Chapman, Kathryn; Graf, Gavin; Stanfield, Bret; Waterbor, John W

    2014-03-01

    The Alabama Comprehensive Cancer Control Coalition (ACCCC) has developed an integrated and coordinated approach to reducing cancer incidence, morbidity, and mortality, and to improving the quality of life for cancer survivors, their families, and their caregivers. The ACCCC is currently in a maintenance phase and a formal plan for sustainability of the coalition was needed to keep the members engaged and productive. A training session in coalition sustainability conducted in 2013 identified the following elements as essential to success: (1) increased marketing of the coalition by simplifying its mission; (2) improved networking including flexibility in coalition meeting location and attendance; (3) increased membership satisfaction through transformational leadership; (4) revision of the working structure of committees and improved accountability; and (5) enhancement of partner satisfaction with coalition activities designed to recruit and retain new partners. A self-administered membership satisfaction survey was given to assess coalition mission, meeting logistics, organization, capacity building, and coalition goals. Results indicated that the subcategories of communication, mission, and meeting logistics were rated satisfied to very satisfied on a five-point scale. Although the ACCCC had clearly written goals, improvement could be made in leadership participation and new member orientation could be improved. Most members rated their parent organization as highly involved with the ACCCC and many offered suggestions on capacity building. Results of the sustainability training have clarified the ACCCC's plans to ensure coalition viability and improve strategies to inform stakeholders of the benefits of participation in the coalition. PMID:24132542

  6. Eat for health: a nutrition and cancer control supermarket intervention.

    Science.gov (United States)

    Light, L; Tenney, J; Portnoy, B; Kessler, L; Rodgers, A B; Patterson, B; Mathews, O; Katz, E; Blair, J E; Evans, S K

    1989-01-01

    The growing evidence linking dietary patterns to the incidence and prevention of chronic disease has prompted a number of prominent health and scientific agencies to publish dietary guidelines for the public. Some dietary guidelines address specific diseases, such as cancer or heart disease; others focus on overall health promotion. This situation has created a demand for nutrition education and information programs for the public. Increasingly, supermarkets are seen as potential sites for effective consumer education. Eat for Health is a joint research study by the National Cancer Institute (NCI) and Giant Food Inc., a regional supermarket chain in the Washington-Baltimore area. The study's goal was to test the feasibility of supermarkets as a site for consumer nutrition education. Eat for Health's educational focus was diet and cancer control issues in the context of dietary patterns that promote health. Particular attention was paid to reduction of fat intake and increases in consumption of dietary fiber from grains, vegetables, and fruits. Analysis of program results is currently underway; data should be available in early 1990.

  7. Sustainability in a state comprehensive cancer control coalition: lessons learned.

    Science.gov (United States)

    Desmond, Renee A; Chapman, Kathryn; Graf, Gavin; Stanfield, Bret; Waterbor, John W

    2014-03-01

    The Alabama Comprehensive Cancer Control Coalition (ACCCC) has developed an integrated and coordinated approach to reducing cancer incidence, morbidity, and mortality, and to improving the quality of life for cancer survivors, their families, and their caregivers. The ACCCC is currently in a maintenance phase and a formal plan for sustainability of the coalition was needed to keep the members engaged and productive. A training session in coalition sustainability conducted in 2013 identified the following elements as essential to success: (1) increased marketing of the coalition by simplifying its mission; (2) improved networking including flexibility in coalition meeting location and attendance; (3) increased membership satisfaction through transformational leadership; (4) revision of the working structure of committees and improved accountability; and (5) enhancement of partner satisfaction with coalition activities designed to recruit and retain new partners. A self-administered membership satisfaction survey was given to assess coalition mission, meeting logistics, organization, capacity building, and coalition goals. Results indicated that the subcategories of communication, mission, and meeting logistics were rated satisfied to very satisfied on a five-point scale. Although the ACCCC had clearly written goals, improvement could be made in leadership participation and new member orientation could be improved. Most members rated their parent organization as highly involved with the ACCCC and many offered suggestions on capacity building. Results of the sustainability training have clarified the ACCCC's plans to ensure coalition viability and improve strategies to inform stakeholders of the benefits of participation in the coalition.

  8. Estimating and modelling cure in population-based cancer studies within the framework of flexible parametric survival models

    Directory of Open Access Journals (Sweden)

    Eloranta Sandra

    2011-06-01

    Full Text Available Abstract Background When the mortality among a cancer patient group returns to the same level as in the general population, that is, the patients no longer experience excess mortality, the patients still alive are considered "statistically cured". Cure models can be used to estimate the cure proportion as well as the survival function of the "uncured". One limitation of parametric cure models is that the functional form of the survival of the "uncured" has to be specified. It can sometimes be hard to find a survival function flexible enough to fit the observed data, for example, when there is high excess hazard within a few months from diagnosis, which is common among older age groups. This has led to the exclusion of older age groups in population-based cancer studies using cure models. Methods Here we have extended the flexible parametric survival model to incorporate cure as a special case to estimate the cure proportion and the survival of the "uncured". Flexible parametric survival models use splines to model the underlying hazard function, and therefore no parametric distribution has to be specified. Results We have compared the fit from standard cure models to our flexible cure model, using data on colon cancer patients in Finland. This new method gives similar results to a standard cure model, when it is reliable, and better fit when the standard cure model gives biased estimates. Conclusions Cure models within the framework of flexible parametric models enables cure modelling when standard models give biased estimates. These flexible cure models enable inclusion of older age groups and can give stage-specific estimates, which is not always possible from parametric cure models.

  9. Barriers to colorectal cancer screening: A case-control study

    Institute of Scientific and Technical Information of China (English)

    Shan-Rong Cai; Su-Zhan Zhang; Shu Zheng; Hong-Hong Zhu

    2009-01-01

    AIM:To investigate barriers to colorectal cancer (CRC) screening in a community population. METHODS:We conducted a community-based case-control study in an urban Chinese population by questionnaire. Cases were selected from those completing both a fecal occult blood test (FOBT) case and colonoscopy in a CRC screening program in 2004. Control groups were matched by gender, age group and community. Control 1 included those having a positive FOBT but refusing a colonoscopy. Control 2 included those who refused both an FOBT and colonoscopy. RESULTS:The impact of occupation on willingness to attend a colorectal screening program differed by gender. P for heterogeneity was 0.009 for case vs control group 1, 0.01 for case versus control group 2, and 0.80 for control group 1 vs 2. Poor awareness of CRC and its screening program, characteristics of screening tests, and lack of time affected the screening rate. Financial support, fear of pain and bowel preparation were barriers to a colonoscopy as a screening test. Eighty-two percent of control group 1 and 87.1% of control group 2 were willing attend if the colonoscopy was free, but only 56.3% and 53.1%,respectively, if it was self-paid. Multivariate odds ratios for case vs control group 1 were 0.10 among those unwilling to attend a free colonoscopy and 0.50 among those unwilling to attend a self-paid colonoscopy. CONCLUSION:Raising the public awareness of CRC and its screening, integrating CRC screening into the health care system, and using a painless colonoscopy would increase its screening rate.

  10. Automatic and consistent registration framework for temporal pairs of mammograms in application to breast cancer risk assessment due to hormone replacement therapy (HRT)

    DEFF Research Database (Denmark)

    Karemore, Gopal Raghunath; Carreras, I. Arganda; Nielsen, Mads

    2009-01-01

     Purpose: Mammographic density is a strong risk factor for breast cancer. However, whether changes in mammographic density due to HRT are associated with risk remains unclear. The aim of this study is to provide a framework for accurate interval change analysis in temporal pairs of mammograms of ...

  11. Manganese Superoxide Dismtase Polymorphism and Breast Cancer Recurrence: A Danish Population-Based Case-Control Study of Breast Cancer Patients Treated with Cyclophosphamide Epirubicin and 5-fluorouracil

    DEFF Research Database (Denmark)

    Ording, Anne Gulbech; Cronin Fenton, Deirdre; Christensen, Mariann;

    2013-01-01

    Manganese Superoxide Dismtase Polymorphism and Breast Cancer Recurrence: A Danish Population-Based Case-Control Study of Breast Cancer Patients Treated with Cyclophosphamide Epirubicin and 5-fluorouracil......Manganese Superoxide Dismtase Polymorphism and Breast Cancer Recurrence: A Danish Population-Based Case-Control Study of Breast Cancer Patients Treated with Cyclophosphamide Epirubicin and 5-fluorouracil...

  12. Effect of pamidronate on pain control in breast cancer patients

    International Nuclear Information System (INIS)

    Objective: One of the common complaints in advanced breast cancer is pain. This is due to osseous metastasis. Analgesics, along with chemotherapy and hormonal therapy, are the mainstay of treatment. Multifocal bone disease that is refractory to above routine treatments can benefit from a series of agents like Pamidronate. Design: Prospective comparative study. Place and Duration of Study: Study was carried out from February 1998 to January 2001 in the Department of Radiotherapy / Oncology, Services Hospital, Lahore. Subjects and Methods: Sixty patients suffering from metastatic breast cancer (mainly to bones) initially treated with chemotherapy or hormonal therapy and analgesics were treated with 60-90 mg of injection Pamidronate by 4-hour intravenous infusion once a month for three or more months. The intensity of pain was assessed by the memorial symptom assessment scale and marked on the pain control performa according to frequency of pain, severity of pain or interference in daily activities due to pain at the start and after six months time of inclusion in the study. Difference in frequency of pain, severity or interference in daily routine was measured for each patient individually. Results: Marked pain relief was reported by 60% of patients who were additionally taking Pamidronate as compared to 43.3% patients who were not taking Pamidronate. Reduction in pain and analgesic demand is noted more in chemotherapy group with Pamidronate as compared to hormonal therapy group. Conclusion: Pamidronate can be additionally used in resistant cases for pain control. (author)

  13. Rac and Rho GTPases in cancer cell motility control

    Directory of Open Access Journals (Sweden)

    Parri Matteo

    2010-09-01

    Full Text Available Abstract Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation. A common theme of these processes is a dynamic reorganization of actin cytoskeleton which has now emerged as a major switch control mainly carried out by Rho and Rac GTPase subfamilies, playing an acknowledged role in adaptation of cell motility to the microenvironment. Cells exhibit three distinct modes of migration when invading the 3 D environment. Collective motility leads to movement of cohorts of cells which maintain the adherens junctions and move by photolytic degradation of matrix barriers. Single cell mesenchymal-type movement is characterized by an elongated cellular shape and again requires extracellular proteolysis and integrin engagement. In addition it depends on Rac1-mediated cell polarization and lamellipodia formation. Conversely, in amoeboid movement cells have a rounded morphology, the movement is independent from proteases but requires high Rho GTPase to drive elevated levels of actomyosin contractility. These two modes of cell movement are interconvertible and several moving cells, including tumor cells, show an high degree of plasticity in motility styles shifting ad hoc between mesenchymal or amoeboid movements. This review will focus on the role of Rac and Rho small GTPases in cell motility and in the complex relationship driving the reciprocal control between Rac and Rho granting for the opportunistic motile behaviour of aggressive cancer cells. In addition we analyse the role of these GTPases in cancer progression and metastatic dissemination.

  14. Planetary micro-rover operations on Mars using a Bayesian framework for inference and control

    Science.gov (United States)

    Post, Mark A.; Li, Junquan; Quine, Brendan M.

    2016-03-01

    With the recent progress toward the application of commercially-available hardware to small-scale space missions, it is now becoming feasible for groups of small, efficient robots based on low-power embedded hardware to perform simple tasks on other planets in the place of large-scale, heavy and expensive robots. In this paper, we describe design and programming of the Beaver micro-rover developed for Northern Light, a Canadian initiative to send a small lander and rover to Mars to study the Martian surface and subsurface. For a small, hardware-limited rover to handle an uncertain and mostly unknown environment without constant management by human operators, we use a Bayesian network of discrete random variables as an abstraction of expert knowledge about the rover and its environment, and inference operations for control. A framework for efficient construction and inference into a Bayesian network using only the C language and fixed-point mathematics on embedded hardware has been developed for the Beaver to make intelligent decisions with minimal sensor data. We study the performance of the Beaver as it probabilistically maps a simple outdoor environment with sensor models that include uncertainty. Results indicate that the Beaver and other small and simple robotic platforms can make use of a Bayesian network to make intelligent decisions in uncertain planetary environments.

  15. A Unified Point Process Probabilistic Framework to Assess Heartbeat Dynamics and Autonomic Cardiovascular Control

    Directory of Open Access Journals (Sweden)

    Zhe eChen

    2012-02-01

    Full Text Available In recent years, time-varying inhomogeneous point process models have been introduced for assessment of instantaneous heartbeat dynamics as well as specific cardiovascular control mechanisms and hemodynamics. Assessment of the model's statistics is established through the Wiener-Volterra theory and a multivariate autoregressive (AR structure. A variety of instantaneous cardiovascular metrics, such as heart rate (HR, heart rate variability (HRV, respiratory sinus arrhythmia (RSA, and baroreceptor-cardiac reflex (baroreflex sensitivity (BRS, are derived within a parametric framework and instantaneously updated with adaptive and local maximum likelihood estimation algorithms. Inclusion of second order nonlinearities, with subsequent bispectral quantification in the frequency domain, further allows for definition of instantaneous metrics of nonlinearity. We here organize a comprehensive review of the devised methods as applied to experimental recordings from healthy subjects during propofol anesthesia. Collective results reveal interesting dynamic trends across the different pharmacological interventions operated within each anesthesia session, confirming the ability of the algorithm to track important changes in cardiorespiratory elicited interactions, and pointing at our mathematical approach as a promising monitoring tool for an accurate, noninvasive assessment in clinical practice.

  16. A Simulation-Based Framework for the Cooperation of VMS Travel Guidance and Traffic Signal Control

    Directory of Open Access Journals (Sweden)

    Meng Li

    2014-01-01

    Full Text Available Nowadays, both travel guidance systems and traffic signal control systems are quite common for urban traffic management. In order to achieve collaborative effect, different models had been proposed in the last two decades. In recent years, with the development of variable message sign (VMS technology, more and more VMS panels are installed on major arterials to provide highly visible and concise graphs or text messages to drivers, especially in developing countries. To discover drivers’ responses to VMS, we establish a drivers’ en route diversion model according to a stated-preference survey. Basically, we proposed a cooperative mechanism and systematic framework of VMS travel guidance and major arterials signal operations. And then a two-stage nested optimization problem is formulated. To solve this optimization problem, a simulation-based optimization method is adopted to optimize the cooperative strategies with TRANSIMS. The proposed method is applied to the real network of Tianjin City comprising of 30 nodes and 46 links. Simulations show that this new method could well improve the network condition by 26.3%. And analysis reveals that GA with nested dynamic programming is an effective technique to solve the optimization problem.

  17. A Unified Pricing of Variable Annuity Guarantees under the Optimal Stochastic Control Framework

    Directory of Open Access Journals (Sweden)

    Pavel V. Shevchenko

    2016-07-01

    Full Text Available In this paper, we review pricing of the variable annuity living and death guarantees offered to retail investors in many countries. Investors purchase these products to take advantage of market growth and protect savings. We present pricing of these products via an optimal stochastic control framework and review the existing numerical methods. We also discuss pricing under the complete/incomplete financial market models, stochastic mortality and optimal/sub-optimal policyholder behavior, and in the presence of taxes. For numerical valuation of these contracts in the case of simple risky asset process, we develop a direct integration method based on the Gauss-Hermite quadratures with a one-dimensional cubic spline for calculation of the expected contract value, and a bi-cubic spline interpolation for applying the jump conditions across the contract cashflow event times. This method is easier to implement and faster when compared to the partial differential equation methods if the transition density (or its moments of the risky asset underlying the contract is known in closed form between the event times. We present accurate numerical results for pricing of a Guaranteed Minimum Accumulation Benefit (GMAB guarantee available on the market that can serve as a numerical benchmark for practitioners and researchers developing pricing of variable annuity guarantees to assess the accuracy of their numerical implementation.

  18. A Universal Communication Framework and Navigation Control Software for Mobile Prototyping Platforms

    Directory of Open Access Journals (Sweden)

    Andreas Mitschele-Thiel

    2010-09-01

    Full Text Available In our contribution we would like to describe two new aspects of our low-cost mobile prototyping platform concept: a new hardware communication framework as well as new software features for navigation and control of our mobile platform. The paper is an extension of the ideas proposed in REV2009 [1] and is based on the therein used hardware platform and the monitoring and management software. This platform is based on the Quadrocopter concept – autonomous flying helicopter-style robots – and includes additional off-the-shelf parts. This leads to a universal mobile prototyping platform for communication tasks providing both mobile phone and WiFi access. However, the platform can provide these functions far more quickly than a technician on the ground might be able to. We will show that with our concept we can easily adapt the platform to the individual needs of the user, which leads to a very flexible and semi-autonomous system.

  19. Spatially-Distributed Cost-Effectiveness Analysis Framework to Control Phosphorus from Agricultural Diffuse Pollution.

    Directory of Open Access Journals (Sweden)

    Runzhe Geng

    Full Text Available Best management practices (BMPs for agricultural diffuse pollution control are implemented at the field or small-watershed scale. However, the benefits of BMP implementation on receiving water quality at multiple spatial is an ongoing challenge. In this paper, we introduce an integrated approach that combines risk assessment (i.e., Phosphorus (P index, model simulation techniques (Hydrological Simulation Program-FORTRAN, and a BMP placement tool at various scales to identify the optimal location for implementing multiple BMPs and estimate BMP effectiveness after implementation. A statistically significant decrease in nutrient discharge from watersheds is proposed to evaluate the effectiveness of BMPs, strategically targeted within watersheds. Specifically, we estimate two types of cost-effectiveness curves (total pollution reduction and proportion of watersheds improved for four allocation approaches. Selection of a ''best approach" depends on the relative importance of the two types of effectiveness, which involves a value judgment based on the random/aggregated degree of BMP distribution among and within sub-watersheds. A statistical optimization framework is developed and evaluated in Chaohe River Watershed located in the northern mountain area of Beijing. Results show that BMP implementation significantly (p >0.001 decrease P loss from the watershed. Remedial strategies where BMPs were targeted to areas of high risk of P loss, deceased P loads compared with strategies where BMPs were randomly located across watersheds. Sensitivity analysis indicated that aggregated BMP placement in particular watershed is the most cost-effective scenario to decrease P loss. The optimization approach outlined in this paper is a spatially hierarchical method for targeting nonpoint source controls across a range of scales from field to farm, to watersheds, to regions. Further, model estimates showed targeting at multiple scales is necessary to optimize program

  20. Patterns of Control over the Teaching-Studying-Learning Process and Classrooms as Complex Dynamic Environments: A Theoretical Framework

    Science.gov (United States)

    Harjunen, Elina

    2012-01-01

    In this theoretical paper the role of power in classroom interactions is examined in terms of a dominance continuum to advance a theoretical framework justifying the emergence of three ways of distributing power when it comes to dealing with the control over the teaching-studying-learning (TSL) "pattern of teacher domination," "pattern of…

  1. Design of an eye-in-hand sensing and servo control framework for harvesting robotics in dense vegetation

    NARCIS (Netherlands)

    Barth, Ruud; Hemming, Jochen; Henten, van E.J.

    2016-01-01

    A modular software framework design that allows flexible implementation of eye-in-hand sensing and motion control for agricultural robotics in dense vegetation is reported. Harvesting robots in cultivars with dense vegetation require multiple viewpoints and on-line trajectory adjustments in order

  2. Personal control after a breast cancer diagnosis : stability and adaptive value

    NARCIS (Netherlands)

    Henselmans, Inge; Sanderman, Robbert; Baas, Peter C.; Smink, Ans; Ranchor, Adelita V.

    2009-01-01

    Objective: This longitudinal study aims to gain more insight in both the changes in personal control due to a breast cancer diagnosis, as well as in the stress-buffering effect of personal control. Methods: Personal control and distress were assessed in breast cancer patients not treated with chemot

  3. Breast cancer in Mexican women: an epidemiological study with cervical cancer control

    Directory of Open Access Journals (Sweden)

    Víctor Tovar-Guzmán

    2000-04-01

    Full Text Available INTRODUCTION: In Mexico, breast cancer (BC is one of the main causes of cancer deaths in women, with increasing incidence and mortality in recent years. Therefore, the aim of the study is identify possible risk factors related to BC. METHODS: An epidemiological study of hospital cases of BC and controls with cervical uterine cancer (CUCA was carried out at eight third level concentration hospitals in Mexico City. The total of 353 incident cases of BC and 630 controls with CUCA were identified among women younger than 75 years who had been residents of the metropolitan area of Mexico City for at least one year. Diagnosis was confirmed histologically in both groups. Variables were analyzed according to biological and statistical plausibility criteria. Univariate, bivariate and multivariate analyses were carried out. Cases and controls were stratified according to the menopausal hormonal status (pre and post menopause. RESULTS: The factors associated with BC were: higher socioeconomic level (OR= 2.77; 95%CI = 1.77 - 4.35; early menarche (OR= 1.32; 95%CI= 0.88 - 2.00; old age at first pregnancy (>31 years: OR= 5.49; 95%CI= 2.16 - 13.98 and a family history of BC (OR= 4.76; 95% CI= 2.10 - 10.79. In contrast, an increase in the duration of the breastfeeding period was a protective factor (>25 months: OR= 0.38; 95%CI= 0.20 - 0.70. CONCLUSIONS: This study contributes to the identification of risk factors for BC described in the international literature, in the population of Mexican women. Breastfeeding appears to play an important role in protecting women from BC. Because of changes in women`s lifestyles, lactation is decreasing in Mexico, and young women tend not to breastfeed or to shorten the duration of lactation.

  4. Breast cancer in Mexican women: an epidemiological study with cervical cancer control

    Directory of Open Access Journals (Sweden)

    Tovar-Guzmán Víctor

    2000-01-01

    Full Text Available INTRODUCTION: In Mexico, breast cancer (BC is one of the main causes of cancer deaths in women, with increasing incidence and mortality in recent years. Therefore, the aim of the study is identify possible risk factors related to BC. METHODS: An epidemiological study of hospital cases of BC and controls with cervical uterine cancer (CUCA was carried out at eight third level concentration hospitals in Mexico City. The total of 353 incident cases of BC and 630 controls with CUCA were identified among women younger than 75 years who had been residents of the metropolitan area of Mexico City for at least one year. Diagnosis was confirmed histologically in both groups. Variables were analyzed according to biological and statistical plausibility criteria. Univariate, bivariate and multivariate analyses were carried out. Cases and controls were stratified according to the menopausal hormonal status (pre and post menopause. RESULTS: The factors associated with BC were: higher socioeconomic level (OR= 2.77; 95%CI = 1.77 - 4.35; early menarche (OR= 1.32; 95%CI= 0.88 - 2.00; old age at first pregnancy (>31 years: OR= 5.49; 95%CI= 2.16 - 13.98 and a family history of BC (OR= 4.76; 95% CI= 2.10 - 10.79. In contrast, an increase in the duration of the breastfeeding period was a protective factor (>25 months: OR= 0.38; 95%CI= 0.20 - 0.70. CONCLUSIONS: This study contributes to the identification of risk factors for BC described in the international literature, in the population of Mexican women. Breastfeeding appears to play an important role in protecting women from BC. Because of changes in women`s lifestyles, lactation is decreasing in Mexico, and young women tend not to breastfeed or to shorten the duration of lactation.

  5. Body image in cancer survivors : a systematic review of case-control studies

    NARCIS (Netherlands)

    Lehmann, Vicky; Hagedoorn, Mariët; Tuinman, Marrit A

    2014-01-01

    PURPOSE: There is common consensus that cancer and its treatment can impair the body, but combined evidence of the previous literature in cancer survivors is missing. Therefore, we reviewed body image in cancer survivors and focused on case-control studies, in order to draw conclusions as to whether

  6. Body image in cancer survivors : a systematic review of case-control studies

    NARCIS (Netherlands)

    Lehmann, Vicky; Hagedoorn, Mariet; Tuinman, Marrit A.

    2015-01-01

    There is common consensus that cancer and its treatment can impair the body, but combined evidence of the previous literature in cancer survivors is missing. Therefore, we reviewed body image in cancer survivors and focused on case-control studies, in order to draw conclusions as to whether body ima

  7. Environmental and occupational cancer in Argentina: a case-control lung cancer study

    Directory of Open Access Journals (Sweden)

    Matos Elena

    1998-01-01

    Full Text Available The main objective of this study was to analyze the risks for lung cancer associated with occupational exposures in a developing country where lung cancer is the first cause of mortality from cancer in men. The study involved 200 men with lung cancer and 397 hospital controls. The OR for current smokers was 8.5, whereas former smokers displayed an OR of 5.3. The fraction attributable to smoking was 85%. Statistically significant high ORs were observed for employment in the alcoholic beverages industry (4.5, 95% CI:1.02-20.2, sawmills and wood mills (4.6, 95% CI:1.1-18.4, chemicals/plastics (1.8, 95% CI:1.04-3.2, and pottery, glass, or mineral manufactures (3.4, 95% CI:1.1-10.6. Other high, but not statistically significant, risks were observed for employment in leather shoe industry and repair (2.1, 95% CI:0.8-5.4, rubber industries (3.4, 95% CI:0.9-12.4, metal workers, including welders (1.9, 95% CI:0.8-4.4, motor vehicle mechanics (2.0, 95% CI:0.9-4.2, workers in cleaning services (1.9, 95% CI:0.8-4.5, and for workers in agriculture (2.4, 95% CI:0.9-6.0. Although some of the present results may be due to chance, most are consistent with those of previous investigations in other countries.

  8. An ongoing case–control study to evaluate the NHS Bowel Cancer Screening Programme

    OpenAIRE

    Massat, Nathalie J; Sasieni, Peter D; Parmar, Dharmishta; Duffy, Stephen W

    2014-01-01

    Background Colorectal cancer is the third most common cause of cancer death in both males and females in England. A national bowel cancer screening programme was rolled out in England between 2006 and 2010. In the post-randomised controlled trials epoch, assessment of the impact of the programme using observational studies is needed. This study protocol was set up at the request of the UK Policy Research Unit in Cancer Awareness, Screening and Early Diagnosis to evaluate the effect of the cur...

  9. Reproductive factors related to the risk of colorectal cancer by subsite: a case-control analysis

    OpenAIRE

    Yoo, K-Y; Tajima, K.; M. Inoue; Takezaki, T.; Hirose, K.; Hamajima, N; Park, S.K.; Kang, D. H.; Kato, T; Hirai, T

    1999-01-01

    The authors hypothesized that reproductive factors of colorectal cancer, which are probably mediated by endogenous hormones, would differ according to colonic subsite. Information on reproductive factors was obtained from 372 female colorectal cancer cases (113 proximal colon, 126 distal colon, 133 rectum) and 31 061 cancer-free controls at the Aichi Cancer Center Hospital, Japan, between 1988 and 1995. Multiple logistic analysis showed that late age at interview, family history of colorectal...

  10. Risk Factors for Pancreatic Cancer in China: A Multicenter Case-Control Study

    Directory of Open Access Journals (Sweden)

    Zhaoxu Zheng

    2016-02-01

    Full Text Available Background: Despite having one of the highest mortality rates of all cancers, the risk factors of pancreatic cancer remain unclear. We assessed risk factors of pancreatic cancer in China. Methods: A case-control study design was conducted using data from four hospital-based cancer registries (Henan Provincial Cancer Hospital, Beijing Cancer Hospital, Hebei Provincial Cancer Hospital, and Cancer Hospital of Chinese Academy of Medical Sciences. Controls were equally matched and selected from family members of non-pancreatic cancer patients in the same hospitals. Face-to-face interviews were conducted by trained staff using questionnaires. Conditional logistic regression models were used to assess odd ratios (ORs and 95% confident intervals (CIs. Results: Among 646 recruited participants, 323 were pancreatic cancer patients and 323 were controls. Multivariate logistic analysis suggested that pancreatic cancer family history (adjusted OR 1.23; 95% CI, 1.11–3.70, obesity (adjusted OR 1.77; 95% CI, 1.22–2.57, diabetes (adjusted OR 2.96; 95% CI, 1.48–5.92 and smoking (adjusted OR 1.78; 95% CI, 1.02–3.10 were risk factors for pancreatic cancer, but that drinking tea (adjusted OR 0.49; 95% CI, 0.25–0.84 was associated with reduced risk of pancreatic cancer. Conclusions: Cigarette smoking, family history, obesity, and diabetes are risk factors of pancreatic cancer, which is important information for designing early intervention and preventive strategies for pancreatic cancer and may be beneficial to pancreatic cancer control in China.

  11. Conceptual framework for analysing farm-specific economic effects of helminth infections in ruminants and control strategies.

    Science.gov (United States)

    van der Voort, Mariska; Charlier, Johannes; Lauwers, Ludwig; Vercruysse, Jozef; Van Huylenbroeck, Guido; Van Meensel, Jef

    2013-05-01

    Helminth infections are considered to be an important constraint on livestock productivity worldwide. The economic impact of these infections or their control strategies has traditionally been assessed by their effect on animal performance indicators or traditional economic calculation methods (e.g. budgeting and cost-benefit analysis). Because the impact of helminth infections has become more subtle and is farm-specific, one needs more refined economic evaluations of actions meant to increase or maintain the health of livestock on individual farms. This paper proposes an interdisciplinary framework that combines the developments in the veterinary control of helminth infections with economic performance measurements to identify farm-specific and profitable anthelmintic management decisions. Our framework positions individual farms' performance against performance benchmarks and is based on the farms' efficiency in transforming input(s) into output(s). We show how this positioning makes it possible to establish a linkage between input and output transformation, helminth infection levels and effects of control strategies. Furthermore, the framework allows for the identification of improvement paths that are not necessarily related to the helminth infection, but which may lead to other management improvements. We discuss the epidemiological information required and which complementary methods (e.g. efficiency analysis and budgeting techniques) can be used to make the framework operational.

  12. ASPEN: A Framework for Automated Planning and Scheduling of Spacecraft Control and Operations

    Science.gov (United States)

    Yan, David; Fukunaga, Alex S.; Rabideau, Gregg; Chien, Steve

    1997-01-01

    In this paper, we describe ASPEN (Automated Planning/Scheduling Environment), a modular, reconfigurable application framework which is capable of supporting a wide variety of planning and scheduling applications.

  13. Efficacy of an educational material on second primary cancer screening practice for cancer survivors: a randomized controlled trial.

    Directory of Open Access Journals (Sweden)

    Dong Wook Shin

    Full Text Available BACKGROUND: Cancer surivors have limited knowledge about second primary cancer (SPC screening and suboptimal rates of completion of screening practices for SPC. Our objective was to test the efficacy of an educational material on the knowledge, attitudes, and screening practices for SPC among cancer survivors. METHODS: Randomized, controlled trial among 326 cancer survivors from 6 oncology care outpatient clinics in Korea. Patients were randomized to an intervention or an attention control group. The intervention was a photo-novel, culturally tailored to increase knowledge about SPC screening. Knowledge and attitudes regarding SPC screening were assessed two weeks after the intervention, and screening practices were assessed after one year. RESULTS: At two weeks post-intervention, the average knowledge score was significantly higher in the intervention compared to the control group (0.81 vs. 0.75, P<0.01, with no significant difference in their attitude scores (2.64 vs. 2.57, P = 0.18. After 1 year of follow-up, the completion rate of all appropriate cancer screening was 47.2% in both intervention and control groups. CONCLUSION: While the educational material was effective for increasing knowledge of SPC screening, it did not promote cancer screening practice among cancer survivors. More effective interventions are needed to increase SPC screening rates in this population. TRIAL REGISTRATION: ClinicalTrial.gov NCT00948337.

  14. A Case-Control Study of Oral Contraceptive Use and Incident Breast Cancer

    OpenAIRE

    Rosenberg, Lynn; Zhang, Yuqing; Coogan, Patricia F.; Strom, Brian L; Palmer, Julie R

    2008-01-01

    Oral contraceptive (OC) use has been linked to increased risk of breast cancer, largely on the basis of studies conducted before 1990. In the Case-Control Surveillance Study, a US hospital-based case-control study of medication use and cancer, the authors assessed the relation of OC use to breast cancer risk among 907 case women with incident invasive breast cancer (731 white, 176 black) and 1,711 controls (1,152 white, 559 black) interviewed from 1993 to 2007. They evaluated whether the asso...

  15. The moisture-triggered controlled release of a natural food preservative from a microporous metal-organic framework.

    Science.gov (United States)

    Wang, Hao; Lashkari, Elham; Lim, Hyuna; Zheng, Chong; Emge, Thomas J; Gong, Qihan; Yam, Kit; Li, Jing

    2016-02-01

    In this work we demonstrate that allyl isothiocyanate (AITC), a common food flavoring agent and food preservative, can be effectively captured by and released in a controlled manner from a microporous metal-organic framework (MOF). The extent of AITC-MOF interactions is quantitatively measured by orbital overlap population calculations. Controlled release experiments show that loaded AITC can be released by applying higher relative humidity. Further analysis reveals that the underlying mechanism of the controlled release is associated with the transformation of the MOF from a porous to a nonporous structure at high humidity. This study represents the first example of making use of MOF porosity in food preservation.

  16. Antioxidants and breast cancer risk- a population-based case-control study in Canada

    OpenAIRE

    Morrison Howard; Gibbons Laurie; Zhou Jia; Pan Sai Yi; Wen Shi Wu

    2011-01-01

    Abstract Background The effect of antioxidants on breast cancer is still controversial. Our objective was to assess the association between antioxidants and breast cancer risk in a large population-based case-control study. Methods The study population included 2,362 cases with pathologically confirmed incident breast cancer (866 premenopausal and 1,496 postmenopausal) and 2,462 controls in Canada. Intakes of antioxidants from diet and from supplementation as well as other potential risk fact...

  17. Population-based case-control study of breast cancer in Albania

    OpenAIRE

    Pajenga E.; Rexha T.; Çeliku S.; Mariani E.

    2013-01-01

    In Albania, breast cancer is an important cause of death among women, with increasing incidence from 65 cases in 1970, to 400 cases in 2007. This is the first study concerning breast cancer risk factors in Albania. We used a population-based case-control study of 948 women with breast cancer compared with 1019 controls recruited from other hospitals through random selection. Early age at menarche was found to be a significantly strong risk factor during the pre- and postmenopausal group...

  18. Probiotic Beverage with Soy Isoflavone Consumption for Breast Cancer Prevention: A Case-control Study

    OpenAIRE

    Toi, Masakazu; Hirota, Saya; Tomotaki, Ai; Sato, Nobuaki; Hozumi, Yasuo; Anan, Keisei; Nagashima, Takeshi; Tokuda, Yutaka; Masuda, Norikazu; Ohsumi, Shozo; Ohno, Shinji; Takahashi, Masato; Hayashi, Hironori; Yamamoto, Seiichiro; Ohashi, Yasuo

    2013-01-01

    The purpose of this study is to evaluate how beverages containing Lactobacillus casei Shirota (BLS) and soy isoflavone consumption since adolescence affected the incidence of breast cancer. In a population-based case-control study, three hundred and six cases with breast cancer and 662 controls aged 40 to 55 were matched for age and residential area and included in the analyses. Diet, lifestyle and other breast cancer risk factors were investigated using the self-administered questionnaire an...

  19. A case–control study of reproductive factors, female hormone use, and risk of pancreatic cancer

    OpenAIRE

    Zhang, Yuqing; Coogan, Patricia F.; Palmer, Julie R; Strom, Brian L.; Rosenberg, Lynn

    2009-01-01

    Findings from several previous studies that have assessed the relation of reproductive factors and female hormone use to the risk of pancreatic cancer are inconclusive. The authors examined the association between reproductive factors and the use of oral contraceptives and postmenopausal hormone therapy to the risk of pancreatic cancer among 284 patients with pancreatic cancer and 1,096 controls using data from the hospital-based Case–Control Surveillance Study. Older age at first pregnancy a...

  20. Breast cancer in the Thai Cohort Study: An exploratory case-control analysis

    OpenAIRE

    Jordan, Susan; Lim, Lynette; Vilainerun, Duangkae; Banks, Emily; Sripaiboonkij, Nintita; Seubsman, Sam-ang; Sleigh, Adrian; Bain, Christopher

    2009-01-01

    Breast cancer incidence may be increasing in Thailand but very little research has assessed core breast cancer risk factors in this country. We used baseline questionnaire data from a national cohort study of Thai Open University students in an exploratory case-control study of breast cancer. The study included 43 female cases and 860 age-matched controls selected from the remaining 47,271 female cohort participants. Odds ratios and 95% confidence intervals were calculated using conditional l...

  1. Epidemiology of Oral Cavity Cancers in a Country Located in the Esophageal Cancer Belt: A Case Control Study

    Directory of Open Access Journals (Sweden)

    Babak Saedi

    2012-03-01

    Full Text Available Introduction: As one of the most common cancers among head and neck malignancies, cancer of the oral cavity probably has some variations in countries with a high prevalence of esophageal cancer.  Materials and Methods: Patients with oral cavity cancer who were treated at two tertiary referral centers from January 1999 to January 2009 were included in this study. In addition to demographic data, information regarding personal and family history of head and neck cancer, use of dentures, presence of immune deficiency, consumption of alcohol, and incidence of cigarette smoking was collected. Additionally, a history of opium usage was obtained from the participants in this study. Moreover, an appropriately matched control group was selected for comparisons between the risk factors.   Results: A total of 557 patients were entered into this study over a 10-year period, of whom 219 (39.3% were female and the remaining 338 (60.7% were male. The tongue was the most common site of cancer and 9% of the patients had a history of opium abuse, but more than half of the patients did not have any recognized risk factors. The incidence and stage of cancer had a significant relationship with cigarette smoking (P= 0.013.   Conclusion: Tongue cancer in non-smokers is the predominant pattern of oral cavity cancer in Iran.

  2. Building oceanographic and atmospheric observation networks by composition: unmanned vehicles, communication networks, and planning and execution control frameworks

    Science.gov (United States)

    Sousa, J. T.; Pinto, J.; Martins, R.; Costa, M.; Ferreira, F.; Gomes, R.

    2014-12-01

    The problem of developing mobile oceanographic and atmospheric observation networks (MOAO) with coordinated air and ocean vehicles is discussed in the framework of the communications and control software tool chain developed at Underwater Systems and Technologies Laboratory (LSTS) from Porto University. This is done with reference to field experiments to illustrate key capabilities and to assess future MOAO operations. First, the motivation for building MOAO by "composition" of air and ocean vehicles, communication networks, and planning and execution control frameworks is discussed - in networked vehicle systems information and commands are exchanged among multiple vehicles and operators, and the roles, relative positions, and dependencies of these vehicles and operators change during operations. Second, the planning and execution control framework developed at LSTS for multi-vehicle systems is discussed with reference to key concepts such as autonomy, mixed-initiative interactions, and layered organization. Third, the LSTS tool software tool chain is presented to show how to develop MOAO by composition. The tool chain comprises the Neptus command and control framework for mixed initiative interactions, the underlying IMC messaging protocol, and the DUNE on-board software. Fourth, selected LSTS operational deployments illustrate MOAO capability building. In 2012 we demonstrated the use of UAS to "ferry" data from UUVs located beyond line of sight (BLOS). In 2013 we demonstrated coordinated observations of coastal fronts with small UAS and UUVs, "bent" BLOS through the use of UAS as communication relays, and UAS tracking of juvenile hammer-head sharks. In 2014 we demonstrated UUV adaptive sampling with the closed loop controller of the UUV residing on a UAS; this was done with the help of a Wave Glider ASV with a communications gateway. The results from these experiments provide a background for assessing potential future UAS operations in a compositional MOAO.

  3. Case-control assessment of diet and lung cancer risk in African Americans and Mexican Americans.

    Science.gov (United States)

    Pillow, P C; Hursting, S D; Duphorne, C M; Jiang, H; Honn, S E; Chang, S; Spitz, M R

    1997-01-01

    In this case-control study we determined whether dietary differences underlie some of the ethnic and sex differences in US lung cancer rates. We examined the relationship between diet and lung cancer development in 137 lung cancer cases (93 African Americans and 44 Mexican Americans) and 187 controls (78 African Americans and 109 Mexican Americans). Cases reported a higher daily mean total fat intake (p fruits (p = 0.02). Ethnic differences in diet were also observed: Mexican Americans consumed less total fat (p fruits (p lung cancer risk (p fruit consumption and lung cancer risk (p = 0.05). In conclusion, our findings support the hypothesis that diet, particularly high fat consumption and low fruit and vegetable consumption, contributes (independent of cigarette smoking) to the excess lung cancer risk in African-American men, who have the highest lung cancer rates in the United States.

  4. Intensive glucose control and risk of cancer in patients with type 2 diabetes

    DEFF Research Database (Denmark)

    Stefansdottir, G; Zoungas, S; Chalmers, J;

    2011-01-01

    AIMS/HYPOTHESIS: Type 2 diabetes has been associated with an increased risk of cancer. This study examines the effect of more vs less intensive glucose control on the risk of cancer in patients with type 2 diabetes. METHODS: All 11,140 participants from the Action in Diabetes and Vascular Disease......: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) trial (ClinicalTrials.gov NCT00145925) were studied. Cancer incidence and cancer mortality was compared in groups randomised to intensive or standard glucose control. Information on events during follow-up was obtained from serious adverse event...... death) [corrected].Across all the major organ systems studied, no significant differences in the cancer incidences were observed in the intensive and standard control groups. CONCLUSIONS/INTERPRETATIONS: More intensive glucose control achieved with a regimen that included greater use of gliclazide...

  5. An open-source and cross-platform framework for Brain Computer Interface-guided robotic arm control.

    Science.gov (United States)

    Kubben, Pieter L; Pouratian, Nader

    2012-01-01

    Brain Computer Interfaces (BCIs) have focused on several areas, of which motor substitution has received particular interest. Whereas open-source BCI software is available to facilitate cost-effective collaboration between research groups, it mainly focuses on communication and computer control. We developed an open-source and cross-platform framework, which works with cost-effective equipment that allows researchers to enter the field of BCI-based motor substitution without major investments upfront. It is based on the C++ programming language and the Qt framework, and offers a separate class for custom MATLAB/Simulink scripts. It has been tested using a 14-channel wireless electroencephalography (EEG) device and a low-cost robotic arm that offers 5° of freedom. The software contains four modules to control the robotic arm, one of which receives input from the EEG device. Strengths, current limitations, and future developments will be discussed. PMID:23372966

  6. Understanding, accepting and controlling risks: A multistage framework for risk communication

    NARCIS (Netherlands)

    Vlek, C.A.J.

    1995-01-01

    The meanings and functions of cc risk communication a (RC, for shea) are specified on the basis of a multistage framework for handling societal risks. After identifying various reasons for RC, essential components of > are briefly discussed : basic risk communicator positions, different levels of ri

  7. UNDERSTANDING, ACCEPTING AND CONTROLLING RISKS - A MULTISTAGE FRAMEWORK FOR RISK COMMUNICATION

    NARCIS (Netherlands)

    VLEK, CAJ

    1995-01-01

    The meanings and functions of cc risk communication a (RC, for shea) are specified on the basis of a multistage framework for handling societal risks. After identifying various reasons for RC, essential components of > are briefly discussed : basic risk communicator positions, different levels of ri

  8. Controlling embedment and surface chemistry of nanoclusters in metal-organic frameworks.

    Science.gov (United States)

    Coupry, D E; Butson, J; Petkov, P S; Saunders, M; O'Donnell, K; Kim, H; Buckley, C; Addicoat, M; Heine, T; Szilágyi, P Á

    2016-04-14

    A combined theoretical and experimental approach demonstrates that nanocluster embedment into the pores of metal-organic frameworks (MOF) may be influenced by the chemical functionalisation of the MOF. Furthermore, this results in the surface functionalisation of the embedded nanoclusters, highlighting the potential of MOF scaffolds for the design and synthesis of novel functional materials.

  9. A new numerical framework for simulating the control of weather and climate on the evolution of soil-mantled hillslopes

    Science.gov (United States)

    Bovy, Benoît; Braun, Jean; Demoulin, Alain

    2016-06-01

    We present a new numerical framework for simulating short to long-term hillslope evolution. This modeling framework, to which we have given the name CLICHE (CLImate Control on Hillslope Evolution), aims to better capture the control of climate on soil dynamics. It allows the use of realistic forcing that involves, through a specific time discretization scheme, the variability of both the temperature and precipitation at time scales ranging from the daily rainfall events to the climatic oscillations of the Quaternary, also including seasonal variability. Two simple models of soil temperature and soil water balance permit the link between the climatic inputs and derived quantities that take part in the computation of the soil flux, such as the surface water discharge and the depth of the non-frozen soil layer. Using this framework together with a multi-process parameterization of soil transport, we apply an original method to calculate hillslope effective diffusivity as a function of climate. This allows us to demonstrate the ability of the model to simulate observed rates of hillslope erosion under different climates (cold and temperate) with a single set of parameter values. Numerical experiments furthermore suggest a potential high peak of sediment transport on hillslopes during the glacial-interglacial transitions of the Quaternary. We finally discuss the need to improve the parameterization of the soil production and transport processes in order to explicitly account for other key controlling factors that are also climate-sensitive, such as biological activity.

  10. Framework for Integrating Science Data Processing Algorithms Into Process Control Systems

    Science.gov (United States)

    Mattmann, Chris A.; Crichton, Daniel J.; Chang, Albert Y.; Foster, Brian M.; Freeborn, Dana J.; Woollard, David M.; Ramirez, Paul M.

    2011-01-01

    A software framework called PCS Task Wrapper is responsible for standardizing the setup, process initiation, execution, and file management tasks surrounding the execution of science data algorithms, which are referred to by NASA as Product Generation Executives (PGEs). PGEs codify a scientific algorithm, some step in the overall scientific process involved in a mission science workflow. The PCS Task Wrapper provides a stable operating environment to the underlying PGE during its execution lifecycle. If the PGE requires a file, or metadata regarding the file, the PCS Task Wrapper is responsible for delivering that information to the PGE in a manner that meets its requirements. If the PGE requires knowledge of upstream or downstream PGEs in a sequence of executions, that information is also made available. Finally, if information regarding disk space, or node information such as CPU availability, etc., is required, the PCS Task Wrapper provides this information to the underlying PGE. After this information is collected, the PGE is executed, and its output Product file and Metadata generation is managed via the PCS Task Wrapper framework. The innovation is responsible for marshalling output Products and Metadata back to a PCS File Management component for use in downstream data processing and pedigree. In support of this, the PCS Task Wrapper leverages the PCS Crawler Framework to ingest (during pipeline processing) the output Product files and Metadata produced by the PGE. The architectural components of the PCS Task Wrapper framework include PGE Task Instance, PGE Config File Builder, Config File Property Adder, Science PGE Config File Writer, and PCS Met file Writer. This innovative framework is really the unifying bridge between the execution of a step in the overall processing pipeline, and the available PCS component services as well as the information that they collectively manage.

  11. A Framework for a General Purpose Intelligent Control System for Particle Accelerators. Phase II Final Report

    International Nuclear Information System (INIS)

    Vista Control Systems, Inc. has developed a portable system for intelligent accelerator control. The design is general in scope and is thus configurable to a wide range of accelerator facilities and control problems. The control system employs a multi-layer organization in which knowledge-based decision making is used to dynamically configure lower level optimization and control algorithms

  12. Pilot Implementation of Breast Cancer Early Detection Programs in Colombia

    OpenAIRE

    Murillo, Raúl; Díaz, Sandra; Sánchez, Oswaldo; Perry, Fernando; Piñeros, Marion; Poveda, César; Salguero, Edgar; Osorio, Dimelza

    2008-01-01

    Breast cancer is increasing in developing countries, and Colombia has a double burden from cervical and breast cancer. Suitable guidelines for breast cancer early detection are needed, and the Breast Health Global Initiative provides a favorable framework for breast cancer control in low resource nations. The Colombian National Cancer Institute developed evidence-based guidelines for breast cancer early detection in which coordinated early detection in symptomatic women and hospital-based scr...

  13. Cancer-associated autoantibodies to MUC1 and MUC4--a blinded case–control study of colorectal cancer in UK collaborative trial of ovarian cancer screening

    DEFF Research Database (Denmark)

    Pedersen, Johannes W; Gentry-Maharaj, Aleksandra; Nøstdal, Alexander;

    2014-01-01

    of colorectal cancer diagnosis and healthy controls. Subsequently, the selected biomarkers were evaluated in a blinded nested case–control study using stored serum samples from among the 50,640 women randomized to the multimodal arm of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS), where......Recent reports suggest that autoantibodies directed to aberrantly glycosylated mucins, in particular MUC1 and MUC4, are found in patients with colorectal cancer. There is, however, limited information on the autoantibody levels before clinical diagnosis, and their utility in cancer screening......, at 95% specificity. IgA to MUC4 glycoforms were unable to discriminate between cases and controls in the UKCTOCS sera. Additional analysis was undertaken by combining the data of MUC1-STn and MUC1-Core3 with previously generated data on autoantibodies to p53 peptides, which increased the sensitivity...

  14. Influences of Internal Control Risk Influence When Planning an Audit: An Empirical Study of the Coso Conceptual Framework

    Directory of Open Access Journals (Sweden)

    Pedro Carmona Ibáñez

    2007-12-01

    Full Text Available This paper studies whether the audit profession understands and follows the internal control framework developed in the COSO Report about the assessment of control risks. That is to say, the extent to which auditors assess control risks and transmit such assessments on substantive testing work when planning an audit, and take into account the assumptions of COSO which affect the identification of risks, in line with the new audit approach based on business risks. The results of the statistical tests show that, in general, the participants evaluated control risks and adjusted the quantity and extent of substantive procedures in accordance with the threats of internal control when they were presented by following the conceptual framework of the COSO Report.Este trabajo pretende analizar si la profesión de auditoría comprende y sigue el marco conceptual del control interno desarrollado por el Informe COSO en la evaluación de los riesgos de control. Es decir, en qué medida los auditores valoran los riesgos de control y trasladan tales valoraciones sobre el trabajo sustantivo durante la etapa de planificación de una auditoría, teniendo en cuenta las premisas de COSO que inciden en una adecuada identificación de los riesgos, en la línea del nuevo enfoque de auditoría orientado hacia los riesgos de negocio. Los resultados de las pruebas estadísticas muestran que en general se tiende a estimar el riesgo de control y a ajustar la cantidad y extensión de los procedimientos sustantivos considerando las amenazas de control interno, cuando se presentan siguiendo el esquema del marco conceptual del Informe COSO.

  15. PanScan, the Pancreatic Cancer Cohort Consortium, and the Pancreatic Cancer Case-Control Consortium

    Science.gov (United States)

    The Pancreatic Cancer Cohort Consortium consists of more than a dozen prospective epidemiologic cohort studies within the NCI Cohort Consortium, whose leaders work together to investigate the etiology and natural history of pancreatic cancer.

  16. Effect of glycemic control on the risk of pancreatic cancer: A nationwide cohort study.

    Science.gov (United States)

    Er, Kian-Ching; Hsu, Chen-Yang; Lee, Yi-Kung; Huang, Ming-Yuan; Su, Yung-Cheng

    2016-06-01

    Although the relationship between diabetes and pancreatic cancer has been studied, the effects of glycemic control on pancreatic cancer have never been evaluated. This study investigates the relationship between glycemic control and pancreatic cancer.Data from 1 million National Health Insurance beneficiaries were screened. The study cohort consisted of 46,973 diabetic patients and 652,142 nondiabetic subjects. Of the patients with diabetes, 1114 who had been admitted for hyperglycemic crisis episodes were defined as having poorly controlled diabetes. All adult beneficiaries were followed from January 1, 2005 to December 31, 2013, to determine whether pancreatic cancer was diagnosed. The Cox regression model was applied to compare the adjusted hazards for potential confounders.After controlling for age, sex, urbanization level, socioeconomic status, chronic liver disease, hypertension, coronary artery disease, hyperlipidemia, malignancies, smoking, chronic obstructive pulmonary disease, obesity, history of alcohol intoxication, chronic renal insufficiency, biliary tract disease, chronic pancreatitis, Charlson Comorbidity Index score, and high-dimensional propensity score, the adjusted hazard ratio of pancreatic cancer was 2.53 (95% confidence interval 1.96-3.26) in patients with diabetes. In diabetic patients with poor glycemic control, the hazard ratio of pancreatic cancer was significantly higher (hazard ratio 3.61, 95% confidence interval 1.34-9.78).This cohort study reveals a possible relationship between diabetes and pancreatic cancer. Moreover, poorly controlled diabetes may be associated with a higher possibility of pancreatic cancer. PMID:27311001

  17. Computational Framework for Prediction of Peptide Sequences That May Mediate Multiple Protein Interactions in Cancer-Associated Hub Proteins.

    Directory of Open Access Journals (Sweden)

    Debasree Sarkar

    Full Text Available A considerable proportion of protein-protein interactions (PPIs in the cell are estimated to be mediated by very short peptide segments that approximately conform to specific sequence patterns known as linear motifs (LMs, often present in the disordered regions in the eukaryotic proteins. These peptides have been found to interact with low affinity and are able bind to multiple interactors, thus playing an important role in the PPI networks involving date hubs. In this work, PPI data and de novo motif identification based method (MEME were used to identify such peptides in three cancer-associated hub proteins-MYC, APC and MDM2. The peptides corresponding to the significant LMs identified for each hub protein were aligned, the overlapping regions across these peptides being termed as overlapping linear peptides (OLPs. These OLPs were thus predicted to be responsible for multiple PPIs of the corresponding hub proteins and a scoring system was developed to rank them. We predicted six OLPs in MYC and five OLPs in MDM2 that scored higher than OLP predictions from randomly generated protein sets. Two OLP sequences from the C-terminal of MYC were predicted to bind with FBXW7, component of an E3 ubiquitin-protein ligase complex involved in proteasomal degradation of MYC. Similarly, we identified peptides in the C-terminal of MDM2 interacting with FKBP3, which has a specific role in auto-ubiquitinylation of MDM2. The peptide sequences predicted in MYC and MDM2 look promising for designing orthosteric inhibitors against possible disease-associated PPIs. Since these OLPs can interact with other proteins as well, these inhibitors should be specific to the targeted interactor to prevent undesired side-effects. This computational framework has been designed to predict and rank the peptide regions that may mediate multiple PPIs and can be applied to other disease-associated date hub proteins for prediction of novel therapeutic targets of small molecule PPI

  18. Computational Framework for Prediction of Peptide Sequences That May Mediate Multiple Protein Interactions in Cancer-Associated Hub Proteins.

    Science.gov (United States)

    Sarkar, Debasree; Patra, Piya; Ghosh, Abhirupa; Saha, Sudipto

    2016-01-01

    A considerable proportion of protein-protein interactions (PPIs) in the cell are estimated to be mediated by very short peptide segments that approximately conform to specific sequence patterns known as linear motifs (LMs), often present in the disordered regions in the eukaryotic proteins. These peptides have been found to interact with low affinity and are able bind to multiple interactors, thus playing an important role in the PPI networks involving date hubs. In this work, PPI data and de novo motif identification based method (MEME) were used to identify such peptides in three cancer-associated hub proteins-MYC, APC and MDM2. The peptides corresponding to the significant LMs identified for each hub protein were aligned, the overlapping regions across these peptides being termed as overlapping linear peptides (OLPs). These OLPs were thus predicted to be responsible for multiple PPIs of the corresponding hub proteins and a scoring system was developed to rank them. We predicted six OLPs in MYC and five OLPs in MDM2 that scored higher than OLP predictions from randomly generated protein sets. Two OLP sequences from the C-terminal of MYC were predicted to bind with FBXW7, component of an E3 ubiquitin-protein ligase complex involved in proteasomal degradation of MYC. Similarly, we identified peptides in the C-terminal of MDM2 interacting with FKBP3, which has a specific role in auto-ubiquitinylation of MDM2. The peptide sequences predicted in MYC and MDM2 look promising for designing orthosteric inhibitors against possible disease-associated PPIs. Since these OLPs can interact with other proteins as well, these inhibitors should be specific to the targeted interactor to prevent undesired side-effects. This computational framework has been designed to predict and rank the peptide regions that may mediate multiple PPIs and can be applied to other disease-associated date hub proteins for prediction of novel therapeutic targets of small molecule PPI modulators. PMID

  19. REPRODUCTIVE FACTORS AND COLORECTAL CANCER RISK. Case - control study.

    OpenAIRE

    Adriana Ruseva; Radka Lazarova; Ilko Kosturkov; Vesselina Ianachkova; Stella Yordanova; Zhivka Boneva; Diana Nikolovska

    2015-01-01

    Colorectal cancer is one of the most common cancers worldwide. The role of the female sex hormones in the etiology of the disease is very intriguing. Reproductive factors are surrogate measure of lifetime exposition to the sex hormones. Purpose: Our aim is to investigate the association between the reproductive factors and colorectal carcinoma risk. Materials and methods: We include 234 Bulgarian women in our study – 117 cases with colorectal cancer and the same number of healthy contr...

  20. Controlling misses and false alarms in a machine learning framework for predicting uniformity of printed pages

    Science.gov (United States)

    Nguyen, Minh Q.; Allebach, Jan P.

    2015-01-01

    In our previous work1 , we presented a block-based technique to analyze printed page uniformity both visually and metrically. The features learned from the models were then employed in a Support Vector Machine (SVM) framework to classify the pages into one of the two categories of acceptable and unacceptable quality. In this paper, we introduce a set of tools for machine learning in the assessment of printed page uniformity. This work is primarily targeted to the printing industry, specifically the ubiquitous laser, electrophotographic printer. We use features that are well-correlated with the rankings of expert observers to develop a novel machine learning framework that allows one to achieve the minimum "false alarm" rate, subject to a chosen "miss" rate. Surprisingly, most of the research that has been conducted on machine learning does not consider this framework. During the process of developing a new product, test engineers will print hundreds of test pages, which can be scanned and then analyzed by an autonomous algorithm. Among these pages, most may be of acceptable quality. The objective is to find the ones that are not. These will provide critically important information to systems designers, regarding issues that need to be addressed in improving the printer design. A "miss" is defined to be a page that is not of acceptable quality to an expert observer that the prediction algorithm declares to be a "pass". Misses are a serious problem, since they represent problems that will not be seen by the systems designers. On the other hand, "false alarms" correspond to pages that an expert observer would declare to be of acceptable quality, but which are flagged by the prediction algorithm as "fails". In a typical printer testing and development scenario, such pages would be examined by an expert, and found to be of acceptable quality after all. "False alarm" pages result in extra pages to be examined by expert observers, which increases labor cost. But "false

  1. Perceptions of Cancer Controllability and Cancer Risk Knowledge: The Moderating Role of Race, Ethnicity, and Acculturation

    OpenAIRE

    RAMÍREZ, A. SUSANA; Finney Rutten, Lila J; Oh, April; Vengoechea, Bryan Leyva; Moser, Richard P; Vanderpool, Robin C.; Hesse, Bradford W.

    2013-01-01

    Literature suggests racial/ethnic minorities, particularly those who are less-acculturated, have stronger fatalistic attitudes toward cancer than do non-Latino Whites. Knowledge of cancer prevention is also lower among racial/ethnic minorities. Moreover, low knowledge about cancer risk factors is often associated with fatalistic beliefs. Our study examined fatalism and cancer knowledge by race/ethnicity and explored whether race/ethnicity moderate the association of fatalism with knowledge of...

  2. A model framework to estimate impact and cost of genetics-based sterile insect methods for dengue vector control.

    Directory of Open Access Journals (Sweden)

    Nina Alphey

    Full Text Available Vector-borne diseases impose enormous health and economic burdens and additional methods to control vector populations are clearly needed. The Sterile Insect Technique (SIT has been successful against agricultural pests, but is not in large-scale use for suppressing or eliminating mosquito populations. Genetic RIDL technology (Release of Insects carrying a Dominant Lethal is a proposed modification that involves releasing insects that are homozygous for a repressible dominant lethal genetic construct rather than being sterilized by irradiation, and could potentially overcome some technical difficulties with the conventional SIT technology. Using the arboviral disease dengue as an example, we combine vector population dynamics and epidemiological models to explore the effect of a program of RIDL releases on disease transmission. We use these to derive a preliminary estimate of the potential cost-effectiveness of vector control by applying estimates of the costs of SIT. We predict that this genetic control strategy could eliminate dengue rapidly from a human community, and at lower expense (approximately US$ 2~30 per case averted than the direct and indirect costs of disease (mean US$ 86-190 per case of dengue. The theoretical framework has wider potential use; by appropriately adapting or replacing each component of the framework (entomological, epidemiological, vector control bio-economics and health economics, it could be applied to other vector-borne diseases or vector control strategies and extended to include other health interventions.

  3. A framework for usable end-user privacy control in social software systems

    Directory of Open Access Journals (Sweden)

    Maryam Najafian Razavi

    2011-09-01

    Full Text Available Recent studies have shown that many users struggle to properly manage selective sharing of the diverse information artefacts they deposit in social software tools. Most tools define privacy based on the ‘network of friends’ model, in which all ‘friends’ are created equal and all relationships are reciprocal. This model fails to support the privacy expectations that non-technical users bring from their real-life experiences, such as enabling different degrees of intimacy within one’s network and providing flexible, natural means of managing the volatile social relationships that social software systems confront. Furthermore, the model suffers from lack of empirical grounding and systematic evaluation. This paper presents a framework for building privacy management mechanisms for social software systems that is intuitive and easy to use for the average, non-technical user population of these systems. The framework is based on a grounded theory study of users’ information sharing behaviour in a social software tool. Results inform the design of OpnTag, a social software prototype that facilitates personal and social information management and sharing. Preliminary empirical data suggest that our proposed privacy framework is flexible enough to meet users’ varying information sharing needs in different contexts while maintaining adequate support for usability.

  4. Replication of Prostate Cancer Risk Variants in a Danish Case-Control Association Study

    DEFF Research Database (Denmark)

    Bentzon, Diem Nguyen; Nyegaard, Mette; Børglum, Anders;

    2012-01-01

    Background: Prostate cancer is one of the main causes for cancer morbidity and mortality in Western countries. Recently, several single nucleotide polymorphisms (SNPs) associated with prostate cancer have been identified in genome-wide association studies and multiple variant models have been...... developed to predict prostate cancer risk. The association between genetic markers and clinico-pathological tumor variables has, however, been inconsistent. Methods and Materials: A total of 32 previously identified prostate cancer-associated risk SNPs were genotyped in 648 prostate cancer cases and 526 age......-matched controls. Family history was obtained by questionnaire. Age at diagnosis, clinical tumor variables including pre- and postoperative PSA, Gleason score, and T stage were obtained from prospectively collected clinical data (Aarhus Prostate Cancer Study). The SNPs were genotyped using Sequenom and Taqman...

  5. VHR image region-based classification potential in the framework of the control with remote sensing of the European CAP

    Science.gov (United States)

    Carleer, Alexandre P.; Wolff, Eléonore

    2005-10-01

    In the framework of the European CAP (Common Agricultural Policy), the European Commission imposes on member states to prevent irregularities, and recommends the control with remote sensing (CwRS) of the declared crops and declared area of crop fields. In the framework of remote sensing procedure, the European Commission, by the way of his Joint Research Centre, advises the use of very high spatial resolution (VHR) satellite data. These data are extraordinary from the point of view of the spatial resolution but the use of these kinds of data involves some problems in the traditional per-pixel classification like the salt and pepper effect and the poor spectral resolution of the VHR data. The region-based classification could solve these problems and allows the use of other features on top of spectral features in the classification process. This study present the potential of the VHR data region-based classification to the classification of the agricultural and rural land cover in the framework of the remote sensing control of the European Union CAP.

  6. Evaluating performance of MARTe as a real-time framework for feed-back control system at tokamak device

    Energy Technology Data Exchange (ETDEWEB)

    Yun, Sangwon; Lee, Woongryol; Lee, Taegu; Park, Mikyung; Lee, Sangil [National Fusion Research Institute (NFRI), Gwahangno 169-148, Yuseong-Gu, Daejeon 305-806 (Korea, Republic of); Neto, André C. [Associação EURATOM/IST, Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade Técnica de Lisboa, P-1049-001 Lisboa (Portugal); Wallander, Anders [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul Lez Durance (France); Kim, Young-Kuk, E-mail: ykim@cnu.ac.kr [Chungnam National University, Daejeon 305-764 (Korea, Republic of)

    2013-10-15

    Highlights: •We measured the performance of MARTe by measuring response time and jitter. •We compared the performance of application with and without MARTe. •We compared the performance of MARTe application on different O/Ss. -- Abstract: The Korea Super conducting Tokamak Advanced Research (KSTAR) is performing the task of “Demonstration and Evaluation of ITER CODAC Technologies at KSTAR” whose objective is the evaluation of real-time technologies for decision making on real-time operating systems (RTOS), real-time frameworks and 10 GbE networks. In this task, the Multi-threaded Application Real-Time executor (MARTe) has been evaluated as a real-time framework for real-time feedback control system. The performance of MARTe has been verified by measuring response time and jitter in a path of feedback control from an analog input of a monitoring system to an analog output of an actuator system. In addition, the evaluation has been performed in terms of applicability of MARTe and its performance depending on types of operating system and tuning of CPU affinity and priority. This paper describes the overview of MARTe as a real-time framework, the results of evaluation performance and its implementation.

  7. Lung cancer and arsenic exposure in drinking water: a case-control study in northern Chile

    Directory of Open Access Journals (Sweden)

    Ferreccio Catterina

    1998-01-01

    Full Text Available In some Chilean cities, levels of arsenic (As in drinking water reached 800 µg/L between 1950 and 1970, while current levels are 40 µg/L. To evaluate the causal role of this exposure in lung and bladder cancers, we conducted a case-control study in Regions I, II, and III of the country. From 1994 to 1996, cases diagnosed as lung cancer and two hospital controls were entered in the study; one control was a patient with a cancer, while the other was a patient without cancer, both conditions unrelated to As. Controls were matched with cases by age and sex. A standard survey containing questions about residence, employment, health history, was administered to study subjects. Data on As concentrations in water were obtained from records of the municipal water companies. A total of 151 lung cancer cases and 419 controls (167 with cancer and 242 without cancer were enrolled. Median level of lifetime As exposure was significantly higher among cases, with a clear dose-response relationship between mean As exposure levels, with an OR (95% CI of: 1, 1.7 (0.5-5.1, 3.9 (1.2-13.4, 5.5 (2.2-13.5, and 9.0 (3.6-22 for strata one to five respectively. This study provides new evidence that As in drinking water can cause internal cancers and gives an estimate of the form of this relationship.

  8. 78 FR 20213 - National Cancer Control Month, 2013

    Science.gov (United States)

    2013-04-04

    ... smoking, visit www.BeTobaccoFree.gov . Additional resources on what cancer is and how to prevent it are... Nation, we have measured that progress not just in the lives we have saved, but also in the moments we... efforts to prevent it. Each of us can reduce our risk of developing cancer by maintaining a healthy...

  9. Anti-colorectal cancer immunity : control ‘the force’!

    NARCIS (Netherlands)

    Speetjens, Franciscus Maria

    2013-01-01

    This dissertation reports on the relation between the immune system, colorectal cancer and immunotherapy. In the first part, expression of HLA class I and expression of CXCL5 in colocectal cancer was studied. Low expression of HLA class I in rectal tumors was associated with poor survival of rectal

  10. Strategies for morbidity control of axillary dissection for breast cancer

    NARCIS (Netherlands)

    J. Bonnema (Jorien)

    1998-01-01

    textabstractBreast cancer accounts for one third of all cancers in females in the Netherlands I and the incidence has been increasing world-wide in the past decades 2.. For the majority of patients, surgery forms the primary treatment of choice 3. Dissection of the axillary lymph nodes has been part

  11. Cancer Control Programs in East Asia: Evidence From the International Literature

    OpenAIRE

    Moore, Malcolm A

    2014-01-01

    Cancer is a major cause of mortality and morbidity throughout the world, including the countries of North-East and South-East Asia. Assessment of burden through cancer registration, determination of risk and protective factors, early detection and screening, clinical practice, interventions for example in vaccination, tobacco cessation efforts and palliative care all should be included in comprehensive cancer control programs. The degree to which this is possible naturally depends on the reso...

  12. ABO Blood Group System and Gastric Cancer: A Case-Control Study and Meta-Analysis

    OpenAIRE

    Yingyan Yu; Zhenggang Zhu; Jun Zhang; Min Yan; Bingya Liu; Jianian Zhang; Jun Ji; Zhiwei Wang; Lei Liu

    2012-01-01

    This study focuses on the association between the ABO blood group system and the risk of gastric cancer or Helicobacter pylori infection. The data for the ABO blood group was collected from 1045 cases of gastric cancer, whereby the patient underwent a gastrectomy in Ruijin Hospital, Shanghai. The information on the ABO blood group from 53,026 healthy blood donors was enrolled as control. We searched the Pubmed database on the relationship between ABO blood groups and gastric cancer risk for m...

  13. Space-time clusters of breast cancer using residential histories: A Danish case–control study

    OpenAIRE

    Nordsborg, Rikke Baastrup; Meliker, Jaymie R.; Ersbøll, Annette Kjær; Jacquez, Geoffrey M; Poulsen, Aslak Harbo; Raaschou-Nielsen, Ole

    2014-01-01

    Background A large proportion of breast cancer cases are thought related to environmental factors. Identification of specific geographical areas with high risk (clusters) may give clues to potential environmental risk factors. The aim of this study was to investigate whether clusters of breast cancer existed in space and time in Denmark, using 33 years of residential histories. Methods We conducted a population-based case–control study of 3138 female cases from the Danish Cancer Registry, dia...

  14. Written emotional disclosure for women with ovarian cancer and their partners: randomised controlled trial

    OpenAIRE

    Arden-Close, Emily; Gidron, Yori; Bayne, Louise; Moss-Morris, Rona

    2013-01-01

    Objective: written emotional disclosure for 15–20?min a day over 3 to 4?days improves physical and psychological health and may benefit cancer patients. However, no studies have tested the effectiveness of guided writing in cancer patients and their partners. A randomised controlled trial tested whether writing about the patient's diagnosis and treatment of ovarian cancer using the Guided Disclosure Protocol (GDP) is effective in reducing perceived stress and improving quality of life (QoL) i...

  15. Risk factors for cancer cervix among rural women of a hilly state: A case-control study

    OpenAIRE

    Anita Thakur; Bhupender Gupta; Anmol Gupta; Raman Chauhan

    2015-01-01

    In Himachal Pradesh, cancer cervix is a major public health problem since it ranks as the number one female cancer. A case-control study of 226 newly diagnosed, histopathologically confirmed cases of cancer cervix and equal number of matched controls was conducted at Regional Cancer Center, Himachal Pradesh during the period from July 2008 to October 2009 with the objective to study the common factors associated with cancer cervix. Univariate analysis identified 10 risk factors associated sig...

  16. Nested case-control study on the risk factors of colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    Kun Chen; Jian Cai; Xi-Yong Liu; Xi-Yuan Ma; Kai-Yan Yao; Shu Zheng

    2003-01-01

    AIM: To investigate the risk factors of colon cancer andrectal cancer.METHODS: A nested case-control study was conducted ina cohort of 64 693 subjects who participated in a colorectalcancer screening program from 1989 to 1998 in Jiashancounty, Zhejiang, China. 196 cases of colorectal cancer weredetected from 1990 to 1998 as the case group and 980non-colorectal cancer subjects, matched with factors of age,gender, resident location, were randomly selected from the64 693 cohort as controls. By using univariate analysis andmutivariate conditional logistic regression analysis, the oddsratio (OR) and its 95 % confidence interval (95 %CI) werecalculated between colorectal cancer and personal habits,dietary factors, as well as intestinal related symptoms.RESULTS: The mutivariate analysis results showed that aftermatched with age, sex and resident location, mucous bloodstool history and mixed sources of drinking water were closelyassociated with colon cancer and rectal cancer, OR values forthe mucous blood stool history were 3.508 (95 %CI: 1.370-8.985) and 2.139 (95 %CI: 1.040-4.402) respectively; for themixed drinking water sources, 2.387 (95 %CI: 1.243-4.587)and 1.951 (95 %CI: 1.086-3.506) respectively. All reachedthe significant level with a P-value less than 0.05.CONCLUSION: The study suggested that mucous bloodstool history and mixed sources of drinking water were therisk factors of colon cancer and rectal cancer. There was noany significant association between dietary habits and theincidence of colorectal cancer.

  17. A Case-Control Study of Risk Factors for Prostate Cancer in Iran

    Directory of Open Access Journals (Sweden)

    Mahmoud Mahmoudi

    2010-02-01

    Full Text Available Prostate cancer is a major cause of morbidity and mortality in Iran, yet there are few studies examining risk factors specific to the Iranian context. We conducted a case-control study to explore risk factors for prostate cancer in Mazandaran, Iran from 2005 to 2008. The cases were 137 men with clinicopathologically confirmed prostate cancer. Controls were 137 neighborhood and age match men without prostate cancer by PSA and digit examination. Analysis comprised an exploratory stage to identify potential risk factors, defined as variables associated with case status at the P < 0.20 level in conditional logistic regression. A second stage included all potential risk factors in multiple conditional logistic regression analysis, retaining those associated with prostate cancer at the P < 0.05 level. Potential risk factors for prostate cancer in exploratory analysis included family history of prostate cancer, history of other cancer, prostatitis, alcohol consumption, pipe or hookah smoking, walking to work, duration of occupational physical activity, intensity of occupational physical activity, body mass index, and older age. Multivariate analysis found intensity of occupational physical activity, prostatitis, and older age as independent predictors of increased risk for prostate cancer in this Iranian population. Our study confirms several recognized risk factors for prostate cancer, contributes evidence to the discussions of other hypothesized risk factors, and points to potentially new factors. Findings, along with confirmatory studies, can help guide efforts for early detection, treatment, and prevention for this common malignancy that is set to increase in Iran in future decades.

  18. A one health framework for the evaluation of rabies control programmes: a case study from Colombo City, Sri Lanka.

    Directory of Open Access Journals (Sweden)

    Barbara Häsler

    2014-10-01

    Full Text Available BACKGROUND: One Health addresses complex challenges to promote the health of all species and the environment by integrating relevant sciences at systems level. Its application to zoonotic diseases is recommended, but few coherent frameworks exist that combine approaches from multiple disciplines. Rabies requires an interdisciplinary approach for effective and efficient management. METHODOLOGY/PRINCIPAL FINDINGS: A framework is proposed to assess the value of rabies interventions holistically. The economic assessment compares additional monetary and non-monetary costs and benefits of an intervention taking into account epidemiological, animal welfare, societal impact and cost data. It is complemented by an ethical assessment. The framework is applied to Colombo City, Sri Lanka, where modified dog rabies intervention measures were implemented in 2007. The two options included for analysis were the control measures in place until 2006 ("baseline scenario" and the new comprehensive intervention measures ("intervention" for a four-year duration. Differences in control cost; monetary human health costs after exposure; Disability-Adjusted Life Years (DALYs lost due to human rabies deaths and the psychological burden following a bite; negative impact on animal welfare; epidemiological indicators; social acceptance of dogs; and ethical considerations were estimated using a mixed method approach including primary and secondary data. Over the four years analysed, the intervention cost US $1.03 million more than the baseline scenario in 2011 prices (adjusted for inflation and caused a reduction in dog rabies cases; 738 DALYs averted; an increase in acceptability among non-dog owners; a perception of positive changes in society including a decrease in the number of roaming dogs; and a net reduction in the impact on animal welfare from intermediate-high to low-intermediate. CONCLUSIONS: The findings illustrate the multiple outcomes relevant to stakeholders

  19. Research on Multi-Agent Based Framework of Reconfigurable Shop Floor Control System

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Manufacturing systems are in a dynamically changing e nvironment with uncertainty. Management of complexity, changes and disturbances is one of the key issues of production. The traditional hierarchical control of CIM systems limits the agility and the flexibility of the shop floor control sys tems and makes the reconfiguration and maintenance of shop floor control systems need high cost and much time. So new architectures are required to meet these c hallenges for the shop floor control systems. Rec...

  20. A Framework for Concrete Reputation-Systems with Applications to History-Based Access Control

    DEFF Research Database (Denmark)

    Krukow, Karl Kristian; Nielsen, Mogens; Sassone, Vladimiro

    2005-01-01

    -based trust-management systems provide no formal security-guarantees. In this extended abstract, we describe a mathematical framework for a class of simple reputation-based systems. In these systems, decisions about interaction are taken based on policies that are exact requirements on agents' past histories...... to encode other policies known from the literature, e.g., `one-out-of-k'. The problem of checking a history with respect to a policy is efficient for the basic language, and tractable for the quantified language when policies do not have too many variables....

  1. The power reinforcement framework revisited: mobile technology and management control in home care

    DEFF Research Database (Denmark)

    Nielsen, Jeppe; Andersen, Kim Normann; Danziger, James N.

    2016-01-01

    -making and gained most benefits from mobile technology use, relative to the effects of the technology on the street-level workers who deliver services. Current mobile technology-in-use might be less likely to be power reinforcing because it is far more decentralized and individualized than the mainly expert......Whereas digital technologies are often depicted as being capable of disrupting long-standing power structures and facilitating new governance mechanisms, the power reinforcement framework suggests that information and communications technologies tend to strengthen existing power arrangements within...

  2. A case-control study of risk factors for epithelial ovarian cancer

    Directory of Open Access Journals (Sweden)

    Ghaem Maghami Noori F

    2001-09-01

    Full Text Available Ovarian cancer is second prevalent cancer among gynecologic malignancies and the most common type of ovarian cancer is epithelial form (85-90 percent. To detect the risk factors for the epithelial ovarian cancer, a case-control study was conducted in Valieasr hospital in 1988. In this study, 118 cases with epithelial ovarian cancer (according histological records and 240 controls without any gynecological cancer in gynecologic clinic had been interviewed. For data analysis, T-test, Chi2 test and logistic regression have been used at a =0.05 as level of significance. The mean age in cases was 50±13 and in controls was 49.9±12 years, without significant different. The mean number of pregnancies and parity in cases was less than controls, significantly (P<0.03. The mean months of breast feeding in cases was less than controls (54.9±71.2 versus 82.4±62.7 (P<0.001. The cases had a lower mean age of menarch than controls (P=0.03. 58 percent of cases and 21.3 percent of controls hadn't used any contraception methods (P=0.00001. The mean years of contraception was significantly less in cases versus controls (P<0.001. The odds ratio for epithelial ovarian cancer was 0.24 (95 percent CI: 0.13-0.48 in OCP users, 0.47 (95 percent CI: 0.005-0.43 in TL method, and was 0.41 (95 percent CI: 0.22-0.76 in other contraception methods, relative to women who hadn't used any contraception methods. This study reveals that epithelial ovarian cancer risk increases significantly with earlier menarch, decreasing number of pregnancy, deliveries duration of breast feeding and use of contraception methods. Use of contraception pill and tubal ligation method decreases risk of epithelial ovarian cancer.

  3. 76 FR 2398 - Submission for OMB Review; Comment Request; California Health Interview Survey Cancer Control...

    Science.gov (United States)

    2011-01-13

    ... HUMAN SERVICES National Institutes of Health Submission for OMB Review; Comment Request; California Health Interview Survey Cancer Control Module (CHIS-CCM) 2011 (NCI) SUMMARY: Under the provisions of Section 3507(a)(1)(D) of the Paperwork Reduction Act of 1995, the National Cancer Institute (NCI),...

  4. Economic analyses of breast cancer control in low- and middle-income countries: a systematic review

    NARCIS (Netherlands)

    Zelle, S.G.; Baltussen, R.M.P.M.

    2013-01-01

    BACKGROUND: To support the development of global strategies against breast cancer, this study reviews available economic evidence on breast cancer control in low- and middle-income countries (LMICs). METHODS: A systematic article search was conducted through electronic scientific databases, and stud

  5. A case control study of risk factors associated with female breast cancer

    International Nuclear Information System (INIS)

    To find the association of various risk factors with breast cancer. Study Design: It was a case-control study. Place and Duration of Study: The study was carried out in NORI Hospital Islamabad and Combined Military Hospital Rawalpindi between August, 2013 and February, 2014. Material and Methods: Two hundred breast cancer patients and 200 control subjects were inducted. A short approved and planned questionnaire was used to collect data regarding basic demographic, menstrual and reproductive characteristics of participating females. Cases and controls were then interviewed after taking written consent. Results: Breast cancer patients and control subjects did not differ regarding age (p = 0.15), early menarche (OR for menarche at <13 years vs. ?13=1.3, 95% CI = 0.84 - 2.02), and history of breast cancer in 1st degree relatives did not increase breast cancer risk (OR = 1.0, 95% CI = 0.57 - 1.74). Nulliparous women had significantly higher risk than parous women (OR = 2.43, 95% CI = 1.22 - 4.84) and women with late menopause compared to women with early onset of menopause were also at higher risk for breast cancer (OR for menopause at ? 50 vs. < 50 = 5.16, 95% CI = 2.59 - 10.29). Conclusion: Nulliparity and menopausal age of more than 50 years was associated with increased breast cancer risk. Breast feeding and age less than 25 years at first live birth was not protective against breast cancer. (author)

  6. Intensive glucose control and risk of cancer in patients with type 2 diabetes

    NARCIS (Netherlands)

    Stefansdottir, G.; Zoungas, S.; Chalmers, J.; Kengne, A. P.; Knol, M. J.; Leufkens, H. G. M.; Patel, A.; Woodward, M.; Grobbee, D. E.; De Bruin, M. L.

    2011-01-01

    Type 2 diabetes has been associated with an increased risk of cancer. This study examines the effect of more vs less intensive glucose control on the risk of cancer in patients with type 2 diabetes. All 11,140 participants from the Action in Diabetes and Vascular Disease: Preterax and Diamicron-MR C

  7. Lung cancer risk among bricklayers in a pooled analysis of case-control studies.

    NARCIS (Netherlands)

    Consonni, Dario; De Matteis, Sara; Olsson, Ann; Pesch, Beate; Kromhout, Hans; Straif, Kurt; Brüning, Thomas

    2014-01-01

    OBJECTIVES: Bricklayers may be exposed to several lung carcinogens, including crystalline silica and asbestos. Previous studies reported an excess of lung cancer among these workers. We examined lung cancer risk among bricklayers within SYNERGY, a large international pooled analysis of case-control

  8. Case-control study of cancer deaths in high background radiation areas of China

    International Nuclear Information System (INIS)

    This paper presents the results of a case-control study of deaths from liver, stomach and lung cancers in the high background radiation areas (HBRA) in Yangjiang County and neighboring control areas (CA). The purpose of this study was to explore the probable relationship between the cancer deaths and the environmental mutation-related factors in the two areas, so that the role of elevated natural radiation in cancer mortality could be properly ascertained. The studied numbers of cases of liver, stomach and lung cancers were 64, 28 and 17 in HBRA, and 75, 36 and 13 in CA, respectively. The proportion of the number of cases to that of the controls was 1:1 for liver cancer and 1:2 for cancers of stomach and lung. The factors studied included pesticide, smoking, alcohol consumption, medical X-ray exposure, diet, and the socioeconomic status, such as occupation, education, economic income, living space etc. The data for this study were collected through interviewing. The data collected were analysed by methods of matched and unmatched studies. The results expressed by odds ratio (OR) show that there is no significant between most factors studied and cancer deaths, although the associations of desths from stomach cancer with drinking water of nonwell source and of lung cancer with alcohol consumption in HBRA, and the associations of liver cancer deaths with occupations involving poisonous and noxious substances, pesticide and alcohol, and of lung cancer with pesticide and lower family income in CA can be found. This study has provided some clues for explaining the difference in cancer mortalities between HBRA and CA

  9. A Data Capsule Framework For Web Services: Providing Flexible Data Access Control To Users

    CERN Document Server

    Kannan, Jayanthkumar; Chun, Byung-Gon

    2010-01-01

    This paper introduces the notion of a secure data capsule, which refers to an encapsulation of sensitive user information (such as a credit card number) along with code that implements an interface suitable for the use of such information (such as charging for purchases) by a service (such as an online merchant). In our capsule framework, users provide their data in the form of such capsules to web services rather than raw data. Capsules can be deployed in a variety of ways, either on a trusted third party or the user's own computer or at the service itself, through the use of a variety of hardware or software modules, such as a virtual machine monitor or trusted platform module: the only requirement is that the deployment mechanism must ensure that the user's data is only accessed via the interface sanctioned by the user. The framework further allows an user to specify policies regarding which services or machines may host her capsule, what parties are allowed to access the interface, and with what parameter...

  10. Towards Controlling the Glycoform: A Model Framework Linking Extracellular Metabolites to Antibody Glycosylation

    Directory of Open Access Journals (Sweden)

    Philip M. Jedrzejewski

    2014-03-01

    Full Text Available Glycoproteins represent the largest group of the growing number of biologically-derived medicines. The associated glycan structures and their distribution are known to have a large impact on pharmacokinetics. A modelling framework was developed to provide a link from the extracellular environment and its effect on intracellular metabolites to the distribution of glycans on the constant region of an antibody product. The main focus of this work is the mechanistic in silico reconstruction of the nucleotide sugar donor (NSD metabolic network by means of 34 species mass balances and the saturation kinetics rates of the 60 metabolic reactions involved. NSDs are the co-substrates of the glycosylation process in the Golgi apparatus and their simulated dynamic intracellular concentration profiles were linked to an existing model describing the distribution of N-linked glycan structures of the antibody constant region. The modelling framework also describes the growth dynamics of the cell population by means of modified Monod kinetics. Simulation results match well to experimental data from a murine hybridoma cell line. The result is a modelling platform which is able to describe the product glycoform based on extracellular conditions. It represents a first step towards the in silico prediction of the glycoform of a biotherapeutic and provides a platform for the optimisation of bioprocess conditions with respect to product quality.

  11. Hydrothermal Synthesis of Zeolitic Imidazolate Frameworks-8 (ZIF-8) Crystals with Controllable Size and Morphology

    KAUST Repository

    Lestari, Gabriella

    2012-05-01

    Zeolitic imidazolate frameworks (ZIFs) is a new class of metal-organic frameworks (MOFs) with zeolite-like properties such as permanent porosity, uniform pore size, and exceptional thermal and chemical stability. Until recently, ZIF materials have been mostly synthesized by solvothermal method. In this thesis, further analysis to tune the size and morphology of ZIF-8 is done upon our group’s recent success in preparing ZIF-8 crystals in pure aqueous solutions. Compositional parameters (molar ratio of 2-methylimidazole/Zn2+, type of zinc salt reagents, reagent concentrations, addition of surfactants) as well as process parameters (temperature and time) were systematically investigated. Upon characterizations of as-synthesized samples by X-ray powder diffraction, thermal gravimetric analysis, N2 adsorption, and field-emission scanning electron microscope, the results show that the particle size and morphology of ZIF-8 crystals are extremely sensitive to the compotional parameters of reagent concentration and addition of surfactants. The particle size and morphology of hydrothermally synthesized ZIF-8 crystals can be finely tuned; with the size ranging from 90 nm to 4 μm and the shape from truncated cubic to rhombic dodecahedron.

  12. What are cancer registries

    Directory of Open Access Journals (Sweden)

    Miladinov-Mikov Marica

    2004-01-01

    Full Text Available Introduction Population-based cancer registries attempt to collect, process, analyze, store and interpret data on persons with cancer in a certain population (most frequently a geographical area. Hospital-based cancer registries register all cases in a given hospital, usually without knowledge of the background population; the emphasis is to serve the needs of the hospital administration, the hospital cancer program, and, above all, the individual patient. History of Cancer Registries Registration of persons suffering from cancer is a slow process. Around the year 1900, England and Germany demanded improvement of statistical investigation on spread of cancer in population in order to undertake etiological researches. The oldest example of a modern cancer registry is that in Hamburg. Today there are more than 200 population-based cancer registries, but they cover only 5% of the world population, mainly in developed countries of the world. Cancer registry of Vojvodina Cancer registry of Vojvodina was established in 1966; it is a member of International Agency for Research on Cancer (IARC and it is still the only cancer registry from our country whose data are cited in scientific monographs of IARC. The main purpose of cancer registries is to produce statistics on the occurrence of cancer in a defined populatin and to provide a framework for assessing and controlling the impact of cancer on the community. Cancer registries are essential parts of any rational program of cancer control. Their data can be used in a wide variety of areas of cancer control, ranging from etiological research in epidemiology, through primary and secondary prevention to health-care planning and patient care, so benefiting both the individual and society.

  13. COMDES-II: A Component-Based Framework for Generative Development of Distributed Real-Time Control Systems

    DEFF Research Database (Denmark)

    Ke, Xu; Sierszecki, Krzysztof; Angelov, Christo K.

    2007-01-01

    The paper presents a generative development methodology and component models of COMDES-II, a component-based software framework for distributed embedded control systems with real-time constraints. The adopted methodology allows for rapid modeling and validation of control software at a higher level...... of abstraction, from which a system implementation in C can be automatically synthesized. To achieve this objective, COMDES-II defines formally various kinds of components to address the critical requirements of the targeted domain, taking into consideration both the architectural and behavioral aspects...... methodology for COMDES-II from a general perspective, describes the component models in details and demonstrates their application through a DC-Motor control system case study....

  14. A Research Framework for Demonstrating Benefits of Advanced Control Room Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Le Blanc, Katya [Idaho National Lab. (INL), Idaho Falls, ID (United States); Boring, Ronald [Idaho National Lab. (INL), Idaho Falls, ID (United States); Joe, Jeffrey [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hallbert, Bruce [Idaho National Lab. (INL), Idaho Falls, ID (United States); Thomas, Kenneth [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-12-01

    Control Room modernization is an important part of life extension for the existing light water reactor fleet. None of the 99 currently operating commercial nuclear power plants in the U.S. has completed a full-scale control room modernization to date. A full-scale modernization might, for example, entail replacement of all analog panels with digital workstations. Such modernizations have been undertaken successfully in upgrades in Europe and Asia, but the U.S. has yet to undertake a control room upgrade of this magnitude. Instead, nuclear power plant main control rooms for the existing commercial reactor fleet remain significantly analog, with only limited digital modernizations. Previous research under the U.S. Department of Energy’s Light Water Reactor Sustainability Program has helped establish a systematic process for control room upgrades that support the transition to a hybrid control. While the guidance developed to date helps streamline the process of modernization and reduce costs and uncertainty associated with introducing digital control technologies into an existing control room, these upgrades do not achieve the full potential of newer technologies that might otherwise enhance plant and operator performance. The aim of the control room benefits research presented here is to identify previously overlooked benefits of modernization, identify candidate technologies that may facilitate such benefits, and demonstrate these technologies through human factors research. This report serves as an outline for planned research on the benefits of greater modernization in the main control rooms of nuclear power plants.

  15. A Research Framework for Demonstrating Benefits of Advanced Control Room Technologies

    International Nuclear Information System (INIS)

    Control Room modernization is an important part of life extension for the existing light water reactor fleet. None of the 99 currently operating commercial nuclear power plants in the U.S. has completed a full-scale control room modernization to date. A full-scale modernization might, for example, entail replacement of all analog panels with digital workstations. Such modernizations have been undertaken successfully in upgrades in Europe and Asia, but the U.S. has yet to undertake a control room upgrade of this magnitude. Instead, nuclear power plant main control rooms for the existing commercial reactor fleet remain significantly analog, with only limited digital modernizations. Previous research under the U.S. Department of Energy's Light Water Reactor Sustainability Program has helped establish a systematic process for control room upgrades that support the transition to a hybrid control. While the guidance developed to date helps streamline the process of modernization and reduce costs and uncertainty associated with introducing digital control technologies into an existing control room, these upgrades do not achieve the full potential of newer technologies that might otherwise enhance plant and operator performance. The aim of the control room benefits research presented here is to identify previously overlooked benefits of modernization, identify candidate technologies that may facilitate such benefits, and demonstrate these technologies through human factors research. This report serves as an outline for planned research on the benefits of greater modernization in the main control rooms of nuclear power plants.

  16. An empirical framework of control methods of victims of human trafficking for sexual exploitation

    OpenAIRE

    Ioannou, Maria; Oostinga, Miriam S.D.

    2015-01-01

    Although human trafficking for sexual exploitation is a frequently discussed area in current research, especially on the way that human traffickers control their victims, a recurrent problem is the lack of empirical basis. The present study examines control methods (or conditions) used against 137 victims of human trafficking for sexual exploitation. A multidimensional scaling analysis (smallest space analysis (SSA-I)) of 23 control methods (and conditions) derived from a content analysis of ...

  17. Evolution and Controllability of Cancer Networks: A Boolean Perspective.

    Science.gov (United States)

    Srihari, Sriganesh; Raman, Venkatesh; Leong, Hon Wai; Ragan, Mark A

    2014-01-01

    Cancer forms a robust system capable of maintaining stable functioning (cell sustenance and proliferation) despite perturbations. Cancer progresses as stages over time typically with increasing aggressiveness and worsening prognosis. Characterizing these stages and identifying the genes driving transitions between them is critical to understand cancer progression and to develop effective anti-cancer therapies. In this work, we propose a novel model for the `cancer system' as a Boolean state space in which a Boolean network, built from protein-interaction and gene-expression data from different stages of cancer, transits between Boolean satisfiability states by "editing" interactions and "flipping" genes. Edits reflect rewiring of the PPI network while flipping of genes reflect activation or silencing of genes between stages. We formulate a minimization problem min flip to identify these genes driving the transitions. The application of our model (called BoolSpace) on three case studies-pancreatic and breast tumours in human and post spinal-cord injury (SCI) in rats-reveals valuable insights into the phenomenon of cancer progression: (i) interactions involved in core cell-cycle and DNA-damage repair pathways are significantly rewired in tumours, indicating significant impact to key genome-stabilizing mechanisms; (ii) several of the genes flipped are serine/threonine kinases which act as biological switches, reflecting cellular switching mechanisms between stages; and (iii) different sets of genes are flipped during the initial and final stages indicating a pattern to tumour progression. Based on these results, we hypothesize that robustness of cancer partly stems from "passing of the baton" between genes at different stages-genes from different biological processes and/or cellular components are involved in different stages of tumour progression thereby allowing tumour cells to evade targeted therapy, and therefore an effective therapy should target a "cover set" of

  18. Spatial Analysis of Childhood Cancer: A Case/Control Study

    OpenAIRE

    Rebeca Ramis; Diana Gómez-Barroso; Ibon Tamayo; Javier García-Pérez; Antonio Morales; Elena Pardo Romaguera; Gonzalo López-Abente

    2015-01-01

    Background Childhood cancer was the leading cause of death among children aged 1-14 years for 2012 in Spain. Leukemia has the highest incidence, followed by tumors of the central nervous system (CNS) and lymphomas (Hodgkin lymphoma, HL, and Non-Hodgkin’s lymphoma, NHL). Spatial distribution of childhood cancer cases has been under concern with the aim of identifying potential risk factors. Objective The two objectives are to study overall spatial clustering and cluster detection of cases of t...

  19. Controlling the adsorption enthalpy of CO(2) in zeolites by framework topology and composition.

    Science.gov (United States)

    Grajciar, Lukáš; Čejka, Jiří; Zukal, Arnošt; Otero Areán, Carlos; Turnes Palomino, Gemma; Nachtigall, Petr

    2012-10-01

    Zeolites are often investigated as potential adsorbents for CO(2) adsorption and separation. Depending on the zeolite topology and composition (Si/Al ratio and extra-framework cations), the CO(2) adsorption heats at low coverages vary from -20 to -60 kJ mol(-1), and with increasing surface coverage adsorption heats either stay approximately constant or they quickly drop down. Experimental adsorption heats obtained for purely siliceous porous solids and for ion-exchanged zeolites of the structural type MFI, FER, FAU, LTA, TUN, IMF, and -SVR are discussed in light of results of periodic density functional theory calculations corrected for the description of dispersion interactions. Key factors influencing the stability of CO(2) adsorption complexes are identified and discussed at the molecular level. A general model for CO(2) adsorption in zeolites and related materials is proposed and data reported in literature are evaluated with regard to the proposed model. PMID:22887989

  20. Lung cancer screening: did we really need a randomized controlled trial?

    Science.gov (United States)

    Al-Ayoubi, Adnan M; Flores, Raja M

    2016-07-01

    Lung cancer is the leading cause of cancer mortality in the USA. Within the past decade, two large trials (the National Lung Screening Trial Research and the International Early Lung Cancer Action Program) confirmed a significant role for low-dose CT (LDCT) screening in identifying early stages of cancer leading to reduced mortality in high-risk patients. Given the evidence, the US Preventive Services Task Force issued a recommendation in favour of LDCT screening for high-risk individuals. Despite the strong support for LDCT among physicians who treat lung cancer and cumulative data demonstrating a survival benefit for screening and early detection, it took more than a decade for lung cancer screening to be embraced at the policy level. With many lives lost in the interim, did we really need a randomized controlled trial to make this decision?

  1. Normative framework for radiological protection in medicine: limitations of quality assurance and quality control systems

    International Nuclear Information System (INIS)

    The normative framework of radioprotection in medical exposure represents a set of international and national norms that embody different types of standards varying in legal nature and binding force. These norms seek to provide human health protection through the minimisation of nuclear risks associated with this kind of energy. Their development represents gradual adoption of the preventive approach to radiological risk taking, keeping in mind the uncertainties about the effects of exposure at low doses. The normative concepts and recommendations are contingent on scientific findings and empirical observations on the effects of ionising radiation, and societal perception of nuclear risks as well. Within the EU, the national laws, regulations, and medical practice standards applied by the 'operators on the floor', could vary significantly in Member States, due to: (1) the constant changing of modern health care law, and its high susceptibility to societal demands and market realities, (2) variability of health care law among Member State, and the related normative framework, (3) the central role of Member States in the organisation of health care. Besides, differences in national systems of medical radioprotection are determined by: 1) peculiarities of legislative and regulatory mechanisms (e.g., the use of soft law tools, public/administrative law instruments within the private sphere, delegated regulation, participation of private actors in regulation); 2) patterns of regulatory setting focused on both 'performance' and 'procedure' standards, and representing the mix of performance-based, technology-based and other regulatory approaches; 3) decentralisation of standard-setting of medical practices at the local level. In this respect, the questions still remain open whether: 1) the same (high) level of health protection could be guaranteed for the EU citizens undergoing medical exposure; 2) law can stimulate self-organisation within health care environment and

  2. Transaction-based building controls framework, Volume 2: Platform descriptive model and requirements

    Energy Technology Data Exchange (ETDEWEB)

    Akyol, Bora A. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Haack, Jereme N. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Carpenter, Brandon J. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Katipamula, Srinivas [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Lutes, Robert G. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Hernandez, George [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

    2015-07-31

    Transaction-based Building Controls (TBC) offer a control systems platform that provides an agent execution environment that meets the growing requirements for security, resource utilization, and reliability. This report outlines the requirements for a platform to meet these needs and describes an illustrative/exemplary implementation.

  3. An empirical framework of control methods of victims of human trafficking for sexual exploitation

    NARCIS (Netherlands)

    Ioannou, Maria; Oostinga, Miriam S.D.

    2015-01-01

    Although human trafficking for sexual exploitation is a frequently discussed area in current research, especially on the way that human traffickers control their victims, a recurrent problem is the lack of empirical basis. The present study examines control methods (or conditions) used against 137 v

  4. Urinary strontium and the risk of breast cancer: A case-control study in Guangzhou, China

    International Nuclear Information System (INIS)

    Strontium has been widely used in industries like electronic and pharmacy. It has a carcinogenic potential, however, and no study has been conducted to evaluate its effects on cancer risk. The aim of this study was to explore the possible association between strontium and breast cancer risk in a case-control study including 240 incident invasive breast cancer patients and 246 age-matched controls. We measured the urinary concentrations of strontium by inductively coupled plasma mass spectrometry, and conducted face-to-face interviews to obtain information on potential breast cancer risk factors. Multivariable analysis was used to estimate the association. Creatinine-adjusted levels [median (25th, 75th) μg/g] of strontium were 155.59 (99.05, 230.70) in the breast cancer patients and 119.62 (81.97, 163.76) in the controls. Women in the highest tertile of strontium showed 124% increased risk of breast cancer, when compared with those in the lowest tertile after adjustment for the potential risk factors [OR (95% CI): 2.24 (1.42–3.81)]. This association was particularly strong for HER2 positive breast cancer [OR (95% CI): 10.92 (3.53–33.77)], and only occurred among premenopausal women. These results suggest a potential role of strontium in the development of breast cancer and urge further studies on the environmental contamination and the physiological and pathological mechanisms of strontium.

  5. Comparison of Resting Energy Expenditure Between Cancer Subjects and Healthy Controls: A Meta-Analysis.

    Science.gov (United States)

    Nguyen, Thi Yen Vi; Batterham, Marijka J; Edwards, Cheree

    2016-01-01

    There is conflicting evidence surrounding the extent of changes in resting energy expenditure (REE) in cancer. This meta-analysis aimed to establish the mean difference in REE, as kilojoules per kilogram fat-free mass, among cancer patients when compared to healthy control subjects. The secondary aim was to determine differences among different cancer types. PubMed, Cochrane Library, Medline, Science Direct, Scopus, Web of Science, Wiley Online Library, and ProQuest Central were searched from the earliest records until March 2014. Studies were included if measured REE was reported as kilojoules or kilocalories per kilogram fat-free mass (FFM) in adult subjects with cancer. Twenty-seven studies were included in the meta-analysis. Fourteen studies included both cancer (n = 1453) and control (n = 1145) groups. The meta-analysis shows an average increase in REE of 9.66 (95% confidence interval: 3.34, 15.98) kJ/kgFFM/day in cancer patients when compared to control subjects. Heterogeneity was detected (P < 0.001) which suggest variations in REE among cancer types. Elevations are most noticeable in patients with cancers of metabolically demanding organs.

  6. Urinary strontium and the risk of breast cancer: A case-control study in Guangzhou, China

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Li-Juan [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China); Tang, Lu-Ying [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China); The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630 (China); He, Jian-Rong [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China); Guangzhou Women and Children' s Medical Center, Guangzhou 510623 (China); Su, Yi; Cen, Yu-Ling; Yu, Dan-Dan [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China); Wu, Bang-Hua [The Guangdong Prevention and Treatment Center for Occupational Diseases, Guangzhou 510300 (China); Lin, Ying [The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080 (China); Chen, Wei-Qing [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China); Song, Er-Wei, E-mail: songerwei02@yahoo.com.cn [The Second Affiliated Hospital, Sun Yat-sen University, 107 Yanjiang West, Guangzhou 510120 (China); Ren, Ze-Fang, E-mail: renzef@mail.sysu.edu.cn [The School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou 510080 (China)

    2012-01-15

    Strontium has been widely used in industries like electronic and pharmacy. It has a carcinogenic potential, however, and no study has been conducted to evaluate its effects on cancer risk. The aim of this study was to explore the possible association between strontium and breast cancer risk in a case-control study including 240 incident invasive breast cancer patients and 246 age-matched controls. We measured the urinary concentrations of strontium by inductively coupled plasma mass spectrometry, and conducted face-to-face interviews to obtain information on potential breast cancer risk factors. Multivariable analysis was used to estimate the association. Creatinine-adjusted levels [median (25th, 75th) {mu}g/g] of strontium were 155.59 (99.05, 230.70) in the breast cancer patients and 119.62 (81.97, 163.76) in the controls. Women in the highest tertile of strontium showed 124% increased risk of breast cancer, when compared with those in the lowest tertile after adjustment for the potential risk factors [OR (95% CI): 2.24 (1.42-3.81)]. This association was particularly strong for HER2 positive breast cancer [OR (95% CI): 10.92 (3.53-33.77)], and only occurred among premenopausal women. These results suggest a potential role of strontium in the development of breast cancer and urge further studies on the environmental contamination and the physiological and pathological mechanisms of strontium.

  7. Comparison of Resting Energy Expenditure Between Cancer Subjects and Healthy Controls: A Meta-Analysis.

    Science.gov (United States)

    Nguyen, Thi Yen Vi; Batterham, Marijka J; Edwards, Cheree

    2016-04-01

    There is conflicting evidence surrounding the extent of changes in resting energy expenditure (REE) in cancer. This meta-analysis aimed to establish the mean difference in REE, as kilojoules per kilogram fat-free mass, among cancer patients when compared to healthy control subjects. The secondary aim was to determine differences among different cancer types. PubMed, Cochrane Library, Medline, Science Direct, Scopus, Web of Science, Wiley Online Library, and ProQuest Central were searched from the earliest records until March 2014. Studies were included if measured REE was reported as kilojoules or kilocalories per kilogram fat-free mass (FFM) in adult subjects with cancer. Twenty-seven studies were included in the meta-analysis. Fourteen studies included both cancer (n = 1453) and control (n = 1145) groups. The meta-analysis shows an average increase in REE of 9.66 (95% confidence interval: 3.34, 15.98) kJ/kgFFM/day in cancer patients when compared to control subjects. Heterogeneity was detected (P < 0.001) which suggest variations in REE among cancer types. Elevations are most noticeable in patients with cancers of metabolically demanding organs. PMID:27007947

  8. Exploring Enterprise Systems and Management Control in the Information Society: Developing a Conceptual Framework

    DEFF Research Database (Denmark)

    Rikhardsson, Pall M.; Rohde, Carsten; Rom, Anders

    in the organization as they support and standardize business processes, integrate data, can integrate external business partners into business processes and influence management activities such as planning and control. The main objective of this paper is to add to the limited body of knowledge of the relationship......Society is evolving from the industrial society towards the information society where information technology plays a crucial role. Few IT innovations have had as much impact on business organizations in the past years as Enterprise Systems (ES). These systems affect most functions...... between ES and management control. We describe the changes taking place in companies operating in the information society, describe and define management control and review existing research on the relationship between management control and enterprise systems. We criticize existing management control...

  9. Case-control study of lung cancer among sugar cane farmers in India

    OpenAIRE

    Amre, D. K.; Infante-Rivard, C; Dufresne, A.; P.M Durgawale; Ernst, P

    1999-01-01

    OBJECTIVES: To investigate the risk of lung cancer among sugar cane farmers and sugar mill workers. METHODS: A case-control study was conducted based in six hospitals in the predominantly sugar cane farming districts of the province of Maharashtra in India. Newly diagnosed, histologically confirmed cases were identified from these hospitals between May 1996 and April 1998. Other cancers were chosen as controls and matched to cases by age, sex, district of residence, and timing of diagno...

  10. Randomised controlled trial of effects of coordinating care for terminally ill cancer patients.

    OpenAIRE

    Addington-Hall, J M; MacDonald, L D; Anderson, H R; Chamberlain, J.; Freeling, P.; Bland, J. M.; Raftery, J

    1992-01-01

    OBJECTIVES--To measure effects on terminally ill cancer patients and their families of coordinating the services available within the NHS and from local authorities and the voluntary sector. DESIGN--Randomised controlled trial. SETTING--Inner London health district. PATIENTS--Cancer patients were routinely notified from 1987 to 1990. 554 patients expected to survive less than one year entered the trial and were randomly allocated to a coordination or a control group. INTERVENTION--All patient...

  11. General Palliative Care Guidance for Control of Pain in Patients with Cancer (PDF 56 KB)

    OpenAIRE

    Department of Health; Social Services and Public Safety

    2003-01-01

    This document is intended to be a practical clinical guideline for the control of pain in patients with cancer. Its target group is hospital staff, primary care team members and nursing home staff. It attempts to apply the clinical principles outlined in the document 'Control of Pain in Patients with Cancer' published by "Scottish Intercollegiate Guidelines Network" (SIGN). This document has been adapted with the permission of SIGN. Rigour of Development A full evidence based reference lis...

  12. Human Papillomavirus Antibodies and Future Risk of Anogenital Cancer : A Nested Case-Control Study in the European Prospective Investigation Into Cancer and Nutrition Study

    NARCIS (Netherlands)

    Kreimer, Aimee R.; Brennan, Paul; Kuhs, Krystle A. Lang; Waterboer, Tim; Clifford, Gary; Franceschi, Silvia; Michel, Angelika; Willhauck-Fleckenstein, Martina; Riboli, Elio; Castellsague, Xavier; Hildesheim, Allan; Fortner, Renee Turzanski; Kaaks, Rudolf; Palli, Domenico; Ljuslinder, Ingrid; Panico, Salvatore; Clavel-Chapelon, Francoise; Boutron-Ruault, Marie-Christine; Mesrine, Sylvie; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Peeters, Petra H.; Cross, Amanda J.; Bueno-de-Mesquita, H. Bas; Vineis, Paolo; Larranaga, Nerea; Pala, Valeria; Sanchez, Maria-Jose; Navarro, Carmen; Barricarte, Aurelio; Tumino, Rosario; Khaw, Kay-Tee; Wareham, Nicholas; Boeing, Heiner; Steffen, Annika; Travis, Ruth C.; Ramon Quiros, J.; Weiderpass, Elisabete; Pawlita, Michael; Johansson, Mattias

    2015-01-01

    Purpose Human papillomavirus (HPV) type 16 (HPV16) causes cancer at several anatomic sites. In the European Prospective Investigation Into Cancer and Nutrition study, HPV16 E6 seropositivity was present more than 10 years before oropharyngeal cancer diagnosis and was nearly absent in controls. The c

  13. Does family history of cancer modify the effects of lifestyle risk factors on esophageal cancer? A population-based case-control study in China

    NARCIS (Netherlands)

    Wu, M.; Zhang, Z.F.; Kampman, E.; Zhou, J.Y.; Han, R.Q.; Yang, J.; Zhang, X.F.; Gu, X.P.; Liu, A.M.; Veer, P. van 't; Kok, F.J.; Zhao, J.K.

    2011-01-01

    A population-based case-control study on esophageal cancer has been conducted since 2003 in Jiangsu Province, China. The aim of this analysis is to provide further evidence on the relationship between family history of cancer in first-degree relatives (FH-FDRs) and the risk of esophageal cancer, and

  14. A Building Model Framework for a Genetic Algorithm Multi-objective Model Predictive Control

    DEFF Research Database (Denmark)

    Arendt, Krzysztof; Ionesi, Ana; Jradi, Muhyiddine;

    Model Predictive Control (MPC) of building systems is a promising approach to optimize building energy performance. In contrast to traditional control strategies which are reactive in nature, MPC optimizes the utilization of resources based on the predicted effects. It has been shown that energy...... savings potential of this technique can reach up to 40% compared to conventional control strategies depending on the particular building type. However, the effort needed to implement MPC in buildings is significant and often considered prohibitive. That is why until now fully-functional MPC has been...

  15. Transactive control: a framework for operating power systems characterized by high penetration of distributed energy resources

    DEFF Research Database (Denmark)

    Hu, Junjie; Yang, Guangya; Kok, Koen;

    2016-01-01

    The increasing number of distributed energy resources connected to power systems raises operational challenges for the network operator, such as introducing grid congestion and voltage deviations in the distribution network level, as well as increasing balancing needs at the whole system level....... Control and coordination of a large number of distributed energy assets requires innovative approaches. Transactive control has received much attention due to its decentralized decision-making and transparent characteristics. This paper introduces the concept and main features of transactive control...... by a high penetration of distributed energy resources....

  16. Psychosocial consequences in the Danish randomised controlled lung cancer screening trial (DLCST)

    DEFF Research Database (Denmark)

    F. Rasmussen, Jakob; Siersma, V.; H. Pedersen, J.;

    2015-01-01

    Objectives: To measure the psychosocial consequences in the Danish lung cancer screening trial (DLCST)and compare those between the computed tomography (CT) group and the control group. Materials and methods: This study was a single centre randomised controlled trial with five annual screening...... to complete the validated lung-cancer-specific questionnaire consequences of screening lung cancer (COS-LC). The CT group was also offered a low dose CT scan of the lungs. The COS-LC measures nine scales with psychosocial properties: Anxiety, Behaviour, Dejection, Negative impact on sleep, Self-blame, Focus...

  17. A framework for structural modelling of an RFID-enabled intelligent distributed manufacturing control system

    Directory of Open Access Journals (Sweden)

    Barenji, Ali Vatankhah

    2014-08-01

    Full Text Available A modern manufacturing facility typically contains several distributed control systems, such as machining stations, assembly stations, and material handling and storage systems. Integrating Radio Frequency Identification (RFID technology into these control systems provides a basis for monitoring and configuring their components in real-time. With the right structural modelling, it is then possible to evaluate designs and translate them into new operational applications almost immediately. This paper proposes an architecture for the structural modelling of an intelligent distributed control system for a manufacturing facility, by utilising RFID technology. Emphasis is placed on a requirements analysis of the manufacturing system, the design of RFID-enabled intelligent distributed control systems using Unified Modelling Language (UML diagrams, and the use of efficient algorithms and tools for the implementation of these systems.

  18. Design of High-Fidelity Testing Framework for Secure Electric Grid Control

    Energy Technology Data Exchange (ETDEWEB)

    Yoginath, Srikanth B [ORNL; Perumalla, Kalyan S [ORNL

    2014-01-01

    A solution methodology and implementation components are presented that can uncover unwanted, unintentional or unanticipated effects on electric grids from changes to actual electric grid control software. A new design is presented to leapfrog over the limitations of current modeling and testing techniques for cyber technologies in electric grids. We design a fully virtualized approach in which actual, unmodified operational software under test is enabled to interact with simulated surrogates of electric grids. It enables the software to influence the (simulated) grid operation and vice versa in a controlled, high fidelity environment. Challenges in achieving such capability include achieving low-overhead time control mechanisms in hypervisor schedulers, network capture and time-stamping, translation of network packets emanating from grid software into discrete events of virtual grid models, translation back from virtual sensors/actuators into data packets to control software, and transplanting the entire system onto an accurately and efficiently maintained virtual-time plane.

  19. IMC based feedforward controller framework for disturbance attenuation on uncertain systems.

    Science.gov (United States)

    Vilanova, R; Arrieta, O; Ponsa, P

    2009-10-01

    This paper presents a generalization of the Internal Model Control (IMC) approach to feedforward control action generation. As is well known, one of the distinctive features of the IMC formulation is the possibility to distinguish between the nominal and uncertain situations. However the consideration of the presence of uncertainty for the feedforward part of the controller is not as simple as that for the feedback one. In this sense, what is proposed in this paper provides a more systematic way of addressing a robust feedforward design. In addition, being one of the major drawbacks of the Internal Model Control to have to deal with stable systems, the generalization presented here allows for unstable plants as well as unstable disturbance models.

  20. A Lean Framework for Production Control in Complex and Constrained Construction Projects

    DEFF Research Database (Denmark)

    Lindhard, Søren Munch; Wandahl, Søren

    2014-01-01

    and constrained construction project. Even though several tools have attempted to add structure and to create order, to the complex, dynamic, and uncertain context in which constructions is conducted, none has yet fully succeeded in providing a robust production control system. With outset in the lean tool Last......Production conditions in construction are different than in themanufacturing industry. First of all, construction is rooted in place and conducted as on-site manufacturing. Secondly, every construction project is unique and a one-of-a-kind production, managed by a temporary organization consisting...... and overlapping activities. This increases uncertainty and make the construction process very difficult to plan and control. Additionally, a lot of unpredictable factors (e.g. climate conditions) affects control, and makes construction even more complex. Production control is an essential part of any complex...

  1. The Development of a Generic Framework for the Forensic Analysis of SCADA and Process Control Systems

    Science.gov (United States)

    Slay, Jill; Sitnikova, Elena

    There is continuing interest in researching generic security architectures and strategies for managing SCADA and process control systems. Documentation from various countries on IT security does now begin to recommendations for security controls for (federal) information systems which include connected process control systems. Little or no work exists in the public domain which takes a big picture approach to the issue of developing a generic or generalisable approach to SCADA and process control system forensics. The discussion raised in this paper is that before one can develop solutions to the problem of SCADA forensics, a good understanding of the forensic computing process, and the range of technical and procedural issues subsumed with in this process, need to be understood, and also agreed, by governments, industry and academia.

  2. A Graphical Representation Framework for Enhanced Visualization of Construction Control Processes

    OpenAIRE

    Hays, Benjamin James

    2002-01-01

    Graphical representation for construction control information--processes such as scheduling, budgeting and RFIs--follows no formalized method. Many graphics neglect relevant information necessary to highlight trends in or relationships between processes. The principles of data graphics offer visual capabilities beyond those currently employed by the construction industry to display appropriate information in a manner that enhances comprehension of control processes. This paper describes a ...

  3. "Manejar la Situacion": Partner Notification, Partner Management, and Conceptual Frameworks for HIV/STI Control Among MSM in Peru.

    Science.gov (United States)

    Clark, Jesse L; Perez-Brumer, Amaya; Salazar, Ximena

    2015-12-01

    Previous analyses of partner notification (PN) have addressed individual, interpersonal, social, and structural issues influencing PN outcomes but have paid less attention to the conceptual framework of PN itself. We conducted 18 individual interviews and 8 group discussions, in a two-stage qualitative research process, to explore the meanings and contexts of PN for sexually transmitted infections (STI) among men who have sex with men (MSM) and men who have sex with men and women (MSMW) in Lima, Peru. Participants described PN as the open disclosure of private, potentially stigmatizing information that could strengthen or disrupt a partnership, structured by the tension between concealment and revelation. In addition to informing partners of an STI diagnosis, the act of PN was believed to reveal other potentially stigmatizing information related to sexual identity and practices such as homosexuality, promiscuity, and HIV co-infection. In this context, the potential development of visible, biological STI symptoms represented a risk for disruption of the boundary between secrecy and disclosure that could result in involuntary disclosure of STI status. To address the conflict between concealment and disclosure, participants cited efforts to "manejar la situacion" (manage the situation) by controlling the biological risks of STI exposure without openly disclosing STI status. We use this concept of "managing the situation" as a practical and theoretical framework for comprehensive Partner Management for HIV/STI control systems among MSM in Latin America. PMID:25821149

  4. Metabolomics Analyses of Cancer Cells in Controlled Microenvironments.

    Science.gov (United States)

    Gravel, Simon-Pierre; Avizonis, Daina; St-Pierre, Julie

    2016-01-01

    The tumor microenvironment is a complex and heterogeneous milieu in which cancer cells undergo metabolic reprogramming to fuel their growth. Cancer cell lines grown in vitro using traditional culture methods represent key experimental models to gain a mechanistic understanding of tumor biology. This protocol describes the use of gas chromatography-mass spectrometry (GC-MS) to assess metabolic changes in cancer cells grown under varied levels of oxygen and nutrients that may better mimic the tumor microenvironment. Intracellular metabolite changes, metabolite uptake and release, as well as stable isotope ((13)C) tracer analyses are done in a single experimental setup to provide an integrated understanding of metabolic adaptation. Overall, this chapter describes some essential tools and methods to perform comprehensive metabolomics analyses. PMID:27581029

  5. Tuning porosity via control of interpenetration in a zinc isonicotinate metal organic framework

    Indian Academy of Sciences (India)

    Shyamapada Nandi; Ramanathan Vaidhyanathan

    2014-09-01

    Metal organic frameworks (MOFs) are a class of porous solids formed by linking metal centres or metal clusters by suitable organic ligands capable of generating porosity in the microporous and mesoporous regimes. They have been investigated extensively for their gas storage applications in the last two decades. Interpenetration is nature’s way of avoiding excessive free-space within the large porous networks by growing identical but independent networks within a parent network to decrease the solvent accessible voids and increase stability. A major challenge in MOF synthesis involves minimizing or completely eliminating the extent. In this paper, we report a zinc isonicotinate (or pyridyl-4-carboxylate, 4-PyC) MOF, 1, prepared by tuning the synthesis conditions to minimize interpenetration. The three-fold interpenetration presented in this material is unusual and has been compared to the other zinc isonicotinates to identify the differences contributing to the improved porosity. In addition, the thermal decomposition of 1 in an oxygen-deficient medium has been shown to yield significantly porous carbon embedded with ZnO nanoparticles.

  6. Framework for data intercommunication and control of ATLAS High Level Trigger algorithms

    CERN Document Server

    Ospanov, Rustem; The ATLAS collaboration

    2016-01-01

    The ATLAS experiment at the LHC is equipped with a sophisticated trigger system capable of reducing the 40 MHz LHC collision rate to the 70 kHz rate at the Level 1 hardware trigger and to the average 400 Hz rate at the High Level Trigger (HLT) during the Run 1 data taking in 2010-2012. In the HLT, the Steering Framework manages a few hundred of trigger algorithms: it evaluates every collision event and makes an accept/reject decision using as few resources as possible. Communication among algorithms is facilitated by a data navigation structure, implemented as a directed acyclic graph structure, that allows HLT algorithms fast discovery of detector regions containing interesting physics objects, as well as selecting an optimal way to build and traverse the event graph structure. For ATLAS running after the 2013-2014 shutdown (Run 2), more detailed trigger information is given to physics analysis users thus improving capabilities of trigger aware analyses. To reduce size of event data stored for physics analys...

  7. Controlling micro- and nano-environment of tumor and stem cells for novel research and therapy of brain cancer

    Science.gov (United States)

    Smith, Christopher Lloyd

    The use of modern technologies in cancer research has engendered a great deal of excitement. Many of these advanced approaches involve in-depth mathematical analyses of the inner working of cells, via genomic and proteomic analyses. However these techniques may not be ideal for the study of complex cell phenotypes and behaviors. This dissertation explores cancer and potential therapies through phenotypic analysis of cell behaviors, an alternative approach. We employ this experimental framework to study brain cancer (glioma), a particularly formidable example of this diverse ailment. Through the application of micro- and nanotechnology, we carefully control the surrounding environments of cells to understand their responses to various cues and to manipulate their behaviors. Subsequently we obtain clinically relevant information that allows better understanding of glioma, and enhancement of potential therapies. We first aim to address brain tumor dispersal, through analysis of cell migration. Utilizing nanometer-scale topographic models of the extracellular matrix, we study the migratory response of glioma cells to various stimuli in vitro. Second, we implement knowledge gained from these investigations to define characteristics of tumor progression in patients, and to develop treatments inhibiting cell migration. Next we use microfluidic and nanotopographic models to study the behaviors of stem cells in vitro. Here we attempt to improve their abilities to deliver therapeutic proteins to cancer, an innovative treatment approach. We analyze the multi-step process by which adipose-derived stem cells naturally home to tumor sites, and identify numerous environmental perturbations to enhance this behavior. Finally, we attempt to demonstrate that these cell culture-based manipulations can enhance the localization of adipose stem cells to glioma in vivo using animal models. Throughout this work we utilize environmental cues to analyze and induce particular behaviors in

  8. Design of the control set in the framework of variational data assimilation

    Science.gov (United States)

    Gejadze, I. Yu.; Malaterre, P.-O.

    2016-11-01

    Solving data assimilation problems under uncertainty in basic model parameters and in source terms may require a careful design of the control set. The task is to avoid such combinations of the control variables which may either lead to ill-posedness of the control problem formulation or compromise the robustness of the solution procedure. We suggest a method for quantifying the performance of a control set which is formed as a subset of the full set of uncertainty-bearing model inputs. Based on this quantity one can decide if the chosen 'safe' control set is sufficient in terms of the prediction accuracy. Technically, the method presents a certain generalization of the 'variational' uncertainty quantification method for observed systems. It is implemented as a matrix-free method, thus allowing high-dimensional applications. Moreover, if the Automatic Differentiation is utilized for computing the tangent linear and adjoint mappings, then it could be applied to any multi-input 'black-box' system. As application example we consider the full Saint-Venant hydraulic network model SIC2, which describes the flow dynamics in river and canal networks. The developed methodology seem useful in the context of the future SWOT satellite mission, which will provide observations of river systems the properties of which are known with quite a limited precision.

  9. Case-control study of tobacco smoke exposure and breast cancer risk in Delaware

    Directory of Open Access Journals (Sweden)

    Hathcock H Leroy

    2008-06-01

    Full Text Available Abstract Background Tobacco smoke exposure may be associated with increased breast cancer risk, although the evidence supporting the association is inconclusive. We conducted a case-control study in Delaware, incorporating detailed exposure assessment for active and secondhand smoke at home and in the workplace. Methods Primary invasive breast cancer cases diagnosed among female Delaware residents, ages 40–79, in 2000–2002 were identified through the Delaware cancer registry (n = 287. Delaware drivers license and Health Care Finance Administration records were used to select age frequency-matched controls for women Results A statistically significant increased risk of breast cancer was observed for ever having smoked cigarettes (odds ratio = 1.43, 95% confidence interval = 1.03–1.99. However, there was no evidence of a dose-response relationship between breast cancer risk and total years smoked, cigarettes per day, or pack-years. Neither residential nor workplace secondhand smoke exposure was associated with breast cancer. Recalculations of active smoking risks using a purely unexposed reference group of women who were not exposed to active or secondhand smoking did not indicate increased risks of breast cancer. Conclusion These findings do not support an association between smoking and breast cancer.

  10. ASPNET AJAX Control Development with Visual Studio 2008 and NET 35 Framework

    CERN Document Server

    White, Damien

    2010-01-01

    This Wrox Blox empowers developers to develop ASP.NET AJAX controls by giving them a look "under the hood" of AJAX controls. While this Wrox Blox focuses on Visual Studio 2008 and .NET 3.5, developers should know that the concepts for creating custom controls in Visual Studio 2005 and .NET 2.0 with ASP.NET AJAX 1.0 are very similar. Visual Studio 2008 offers many improvements concerning JavaScript editing/debugging, and .NET 3.5 includes ASP.NET AJAX right out of the box, simplifying the install to get AJAX up and running. This Wrox Blox takes developers gradually through creating a custom ASP

  11. A predictive control framework for optimal energy extraction of wind farms

    Science.gov (United States)

    Vali, M.; van Wingerden, J. W.; Boersma, S.; Petrović, V.; Kühn, M.

    2016-09-01

    This paper proposes an adjoint-based model predictive control for optimal energy extraction of wind farms. It employs the axial induction factor of wind turbines to influence their aerodynamic interactions through the wake. The performance index is defined here as the total power production of the wind farm over a finite prediction horizon. A medium-fidelity wind farm model is utilized to predict the inflow propagation in advance. The adjoint method is employed to solve the formulated optimization problem in a cost effective way and the first part of the optimal solution is implemented over the control horizon. This procedure is repeated at the next controller sample time providing the feedback into the optimization. The effectiveness and some key features of the proposed approach are studied for a two turbine test case through simulations.

  12. An improved filter-u least mean square vibration control algorithm for aircraft framework

    Science.gov (United States)

    Huang, Quanzhen; Luo, Jun; Gao, Zhiyuan; Zhu, Xiaojin; Li, Hengyu

    2014-09-01

    Active vibration control of aerospace vehicle structures is very a hot spot and in which filter-u least mean square (FULMS) algorithm is one of the key methods. But for practical reasons and technical limitations, vibration reference signal extraction is always a difficult problem for FULMS algorithm. To solve the vibration reference signal extraction problem, an improved FULMS vibration control algorithm is proposed in this paper. Reference signal is constructed based on the controller structure and the data in the algorithm process, using a vibration response residual signal extracted directly from the vibration structure. To test the proposed algorithm, an aircraft frame model is built and an experimental platform is constructed. The simulation and experimental results show that the proposed algorithm is more practical with a good vibration suppression performance.

  13. Isoflavone and Soyfood Intake and Colorectal Cancer Risk: A Case-Control Study in Korea.

    Science.gov (United States)

    Shin, Aesun; Lee, Jeonghee; Lee, Jeeyoo; Park, Moon Sung; Park, Ji Won; Park, Sung Chan; Oh, Jae Hwan; Kim, Jeongseon

    2015-01-01

    We aimed to assess the relationship between dietary soyfood and isoflavone intake and colorectal cancer risk in a case-control study. A total of 901 colorectal cancer cases and 2669 controls were recruited at the National Cancer Center, Korea. A semi-quantitative food frequency questionnaire was used to assess the usual dietary habits, and the isoflavone intake level was estimated from five soyfood items. A high intake of total soy products, legumes, and sprouts was associated with a reduced risk for colorectal cancer in men and women, although the middle quartiles of intake of total soy products were associated with an elevated risk. In contrast, a high intake of fermented soy paste was associated with an elevated risk for colorectal cancer in men. The groups with the highest intake quartiles of isoflavones showed a decreased risk for colorectal cancer compared to their counterparts with the lowest intake quartiles in men (odds ratio (OR): 0.67, 95% confidence interval (CI): 0.51-0.89) and women (OR: 0.65, 95% CI: 0.43-0.99). The reduced risk for the highest intake groups persisted for distal colon cancer in men and rectal cancer in women. The association between soyfood intake and colorectal cancer risk was more prominent among post-menopausal women than pre-menopausal women. In conclusion, a high intake of total soy products or dietary isoflavones was associated with a reduced risk for overall colorectal cancer, and the association may be more relevant to distal colon or rectal cancers. PMID:26575841

  14. Quality control of breast cancer screening in Yokohama city for women in their 40 s

    International Nuclear Information System (INIS)

    Biennial screening mammography for breast cancer detection has been carried out in Yokohama City for women aged 50 years and older since October 2001. In three and a half years 49,795 eligible women have been screened, 123 have been diagnosed as having cancer, and the cancer detection rate has been 0.25%. Since 73% of the diagnosed cancers were classified as stage 0 and I, this screening system is considered to have contributed to improving the prognosis of the examines. With regard to quality control, although the rate of women requiring a detailed re-examination has been reduced significantly from 19.1% to 6.9%, the positive predictive value of less than 4% is still insufficient. It is therefore considered that there are some problems with detailed re-examinations. Since screening mammography for breast cancer was extended to women aged 40-49 years in Yokohama City in July 2005, the rate of cancer not detected by mammography was examined in age cohorts of five years among 138 women who were clinically diagnosed as having breast cancer. Because 12.2% of women aged 44 years and younger had no findings on mammography, and cancer was detected in 87.5% of these women by ultrasonography (US), it is recommended that US should be added to mammography for breast cancer examination at this age. (author)

  15. Controller recovery from equipment failures in air traffic control: A framework for the quantitative assessment of the recovery context

    International Nuclear Information System (INIS)

    Air Traffic Control (ATC) involves a complex interaction of human operators (primarily air traffic controllers), equipment and procedures. On the rare occasions when equipment malfunctions, controllers play a crucial role in the recovery process of the ATC system for continued safe operation. Research on human performance in other safety critical industries using human reliability assessment techniques has shown that the context in which recovery from failures takes place has a significant influence on the outcome of the process. This paper investigates the importance of context in which air traffic controller recovery from equipment failures takes place, defining it in terms of 20 Recovery Influencing Factors (RIFs). The RIFs are used to develop a novel approach for the quantitative assessment of the recovery context based on a metric referred to as the Recovery Context Indicator (RCI). The method is validated by a series of simulation exercises conducted at a specific ATC Centre. The proposed method is useful to assess recovery enhancement approaches within ATC centres

  16. A case-control study of diet and lung cancer in Kerala, south India.

    Science.gov (United States)

    Sankaranarayanan, R; Varghese, C; Duffy, S W; Padmakumary, G; Day, N E; Nair, M K

    1994-09-01

    A total of 281 male lung-cancer patients were identified from the hospital cancer registry in the Regional Cancer Centre in Trivandrum. The controls were selected from the visitors and patients' bystanders in the hospital. The recruitment of cases and controls started in 1990, and the present study used the cases registered in the first year. The questionnaire administered to cases and controls collected information on tobacco smoking and alcohol habits. Dietary data were collected using a food frequency questionnaire and were analyzed by multiple logistic regression producing odds ratio estimates of the relative risk and deviance chi-squared tests of significance. Analysis was done on the computer package, EGRET. All models included age, education, religion and smoking to adjust for the effect of confounding. Green vegetables and bananas were found to have a protective association with lung cancer. The odds ratio associated with the highest quartile of vegetable consumption compared with the lowest was 0.32 (95% confidence interval 0.13, 0.78). Forward stepwise regression analysis indicated pumpkins and onions as the most consistently significant protective factors. Animal protein foods and dairy products were found to have a predisposing effect on lung cancer in this study. The expected influence of smoking on lung cancer (a considerable increase in risk among smokers) provided evidence of the reliability of the data. In conclusion the results from this study show that diet has a role in lung cancer aetiology, although the association is weak compared to the effects of smoking. PMID:8077047

  17. Lung cancer and environmental radon exposure: a case-control study

    International Nuclear Information System (INIS)

    Lung cancer accounts for approximately 100,000 deaths annually and nearly 30% of these are due to factors other than smoking. The prognosis for lung cancer is very poor and control of this disease depends on the identification and manipulation of etiologic agents. Radon is a demonstrated pulmonary carcinogen among uranium miners and is a ubiquitous environmental agent. This study addresses two principal issues: (a) the assessment of the potential health effects due to radon exposure from radioactive waste disposal in Canonsburg, Pennsylvania, and (b) the broader scientific question of the existence of an association between lung cancer and environmental radon exposure. Indoor radon concentrations were taken in the homes of 50 lung cancer cases and 48 ASHD controls as an index of cumulative exposure. The distribution of concentrations was similar among case and control homes. The range of exposures was within background expectations as were lung cancer rates in the area. There was, furthermore, no geographic clustering of cases near the tailings site. Although an association between lung cancer and environmental radon exposure cannot be ruled out, the evidence suggests that radon exposure due to the disposal of tailings did not have a significant impact on the health of the residents living in the area and that indoor radon is not an important lung cancer risk factor at concentrations less than about 4pCi/I

  18. Diet as risk for lung cancer: a Swedish case-control study.

    Science.gov (United States)

    Axelsson, Gosta; Rylander, Ragnar

    2002-01-01

    A case-control study was undertaken to study lung cancer in relation to dietary habits, occupational exposure, and living in urban or country areas. Suspect lung cancer cases in West Sweden and population controls were interviewed using a food frequency questionnaire. The study comprised 177 female and 359 male cases and 916 controls. The cases mainly comprised former and current smokers (82% female, 95% male). For the analysis, cases were divided into the histological diagnoses adenocarcinoma and squamous cell, small cell, and adenosquamous cell carcinomas, as well as into smoking categories. A high frequency of consumption of vegetables was significantly related to a lower risk for adenocarcinoma and squamous cell and adenosquamous cell carcinoma among men and adenocarcinoma among women. A low odds ratio in the highest quartile of vegetable consumption in men was seen in all smoking categories. There were no significant protective effects from fruit in the different lung cancer subgroups, although a significant trend was found for heavy-smoking females. A high consumption of milk was related to an increased risk for lung cancer, especially adenosquamous cell carcinoma. The results suggest that the protective effect or risk due to dietary factors may affect different forms of lung cancer. The results from this as well as previous studies suggest a complex interaction between diet and lung cancer risk, involving the types of lung cancer as well as consumption patterns in the population.

  19. An investigation of stochastic cooling in the framework of control theory

    International Nuclear Information System (INIS)

    This thesis provides a description of unbunched beam stochastic cooling in the framework of system theory. The main interest in the investigation is concentrated on the beam stability in an active cooling system. A stochastic cooling system must be considered as a closed-loop, similar to the feedback systems used to damp collective instabilities. These systems, which are able to act upon themselves, are potentially unstable and therefore their stability must be carefully analysed. Assuming a linear transverse cooling interaction, the self-consistent solution for the beam motion is derived by means of a mode analysis of the collective beam motion. Furthermore the calculation treats the pick-up and kicker of the cooling system as localized objects which impose a discrete time structure on the dynamics of the beam particles. This solution then yields a criterion for the stability of each collective mode. The expressions which have been obtained also allow for overlapping frequency bands in the beam spectrum and thus are valid over the entire frequency range. Having established the boundaries of stability in this way, the Fokker-Planck equation is used to describe the cooling process. The drift and diffusion coefficients are derived in the frequency domain taking into account the localization of pick-up and kicker and the sampled nature of the cooling interaction. The Fokker-Planck equation provides a purely statistical description, which does not include collective effects and thus a stable beam must be assumed. Hence the predictions about the cooling process following from the Fokker-Planck equation only make physical sense within the boundaries of beam stability. Finally it is verified that the parameters of the cooling system which give the best cooling results are compatible with the stability of the beam. (orig.)

  20. Framework for the systematic assessment of a material control and accounting system

    Energy Technology Data Exchange (ETDEWEB)

    Schechter, R.S.; Sacks, I.J.

    1981-04-22

    Procedures are described for the systematic assessment of a Material Control and Accounting (MC and A) system, in terms of compliance to the proposed MC and A Upgrade Rule. The applicability of these assessment procedures to specific Rule provisions is discussed. Special attention is given to the statistical performance of individual subsystems, and their vulnerability to compromise by insider collusion.

  1. An Access Control and Trust Management Framework for Loosely-Coupled Multidomain Environments

    Science.gov (United States)

    Zhang, Yue

    2010-01-01

    Multidomain environments where multiple organizations interoperate with each other are becoming a reality as can be seen in emerging Internet-based enterprise applications. Access control to ensure secure interoperation in such an environment is a crucial challenge. A multidomain environment can be categorized as "tightly-coupled" and…

  2. Multi-agent based modeling and execution framework for complex simulation, control and measuring tasks

    NARCIS (Netherlands)

    Papp, Z.; Hoeve, H.J.

    2000-01-01

    The paper presents a modeling concept and a supporting runtime environment, which enables running simulation, control and measuring (data processing) tasks on distributed implementation platforms. Its main features: (1) it is scaleable in various application domains; (2) it has a model based system

  3. Framework for the systematic assessment of a material control and accounting system

    International Nuclear Information System (INIS)

    Procedures are described for the systematic assessment of a Material Control and Accounting (MC and A) system, in terms of compliance to the proposed MC and A Upgrade Rule. The applicability of these assessment procedures to specific Rule provisions is discussed. Special attention is given to the statistical performance of individual subsystems, and their vulnerability to compromise by insider collusion

  4. The modeling of transfer of steering between automated vehicle and human driver using hybrid control framework

    NARCIS (Netherlands)

    Kaustubh, M.; Willemsen, D.M.C.; Mazo, M.

    2016-01-01

    Proponents of autonomous driving pursue driverless technologies, whereas others foresee a gradual transition where there will be automated driving systems that share the control of the vehicle with the driver. With such advances it becomes pertinent that the developed automated systems need to be sa

  5. The potential value of sibling controls compared with population controls for association studies of lifestyle-related risk factors: an example from the Breast Cancer Family Registry

    OpenAIRE

    Milne, Roger L.; John, Esther M.; Julia A. Knight; Dite, Gillian S; Southey, Melissa C; Giles, Graham G.; Apicella, Carmel; West, Dee W.; Andrulis, Irene L; Whittemore, Alice S; Hopper, John L

    2011-01-01

    Background A previous Australian population-based breast cancer case-control study found indirect evidence that control participation, although high, was not random. We hypothesized that unaffected sisters may provide a more appropriate comparison group than unrelated population controls.

  6. The strategies to control prostate cancer by chemoprevention approaches

    International Nuclear Information System (INIS)

    Prostate cancer (PCA) is the most commonly diagnosed cancer in men in the United States with growing worldwide incidence. Despite intensive investment in improving early detection, PCA often escapes timely detection and mortality remains high; this malignancy being the second highest cancer-associated mortality in American men. Collectively, health care costs of PCA results in an immense financial burden that is only expected to grow. Additionally, even in cases of successful treatment, PCA is associated with long-term and pervasive effects on patients. A proactive alternative to treat PCA is to prevent its occurrence and progression prior to symptomatic malignancy. This may serve to address the issue of burgeoning healthcare costs and increasing number of sufferers. One potential regimen in service of this alternative is PCA chemoprevention. Here, chemical compounds with cancer preventive efficacy are identified on the basis of their potential in a host of categories: their historical medicinal use, correlation with reduced risk in population studies, non-toxicity, their unique chemical properties, or their role in biological systems. PCA chemopreventive agents are drawn from multiple broad classes of chemicals, themselves further subdivided based on source or potential effect, with most derived from natural products. Many such compounds have shown efficacy, varying from inhibiting deregulated PCA cell signaling, proliferation, epithelial to mesenchymal transition (EMT), invasion, metastasis, tumor growth and angiogenesis and inducing apoptosis. Overall, these chemopreventive agents show great promise in PCA pre-clinical models, though additional work remains to be done in effectively translating these findings into clinical use

  7. Eat for health: a nutrition and cancer control supermarket intervention

    OpenAIRE

    Light, Luise; Tenney, Janet; Portnoy, Barry; Kessler, Larry; Rodgers, Anne Brown; Patterson, Blossom; Mathews, Odonna; Katz, Eileen; Blair, Joan E.; Evans, Shirley King; Tuckermanty, Elizabeth

    1989-01-01

    The growing evidence linking dietary patterns to the incidence and prevention of chronic disease has prompted a number of prominent health and scientific agencies to publish dietary guidelines for the public. Some dietary guidelines address specific diseases, such as cancer or heart disease; others focus on overall health promotion. This situation has created a demand for nutrition education and information programs for the public.

  8. Cancer Control and Prevention by Nutrition and Epigenetic Approaches

    OpenAIRE

    Verma, Mukesh

    2012-01-01

    Significance: Epigenetics involves alterations in gene expression without changing the nucleotide sequence. Because some epigenetic changes can be reversed chemically, epigenetics has tremendous implications for disease intervention and treatment. Recent Advances: After epigenetic components in cancer were characterized, genes and pathways are being characterized in other diseases such as diabetes, obesity, and neurological disorders. Observational, experimental, and clinical studies in diffe...

  9. Cancer incidence and specific occupational exposures in the Swedish leather tanning industry: a cohort based case-control study.

    OpenAIRE

    Mikoczy, Z; Schütz, A; Strömberg, U; Hagmar, L

    1996-01-01

    OBJECTIVE--To study the effect on the incidence of cancer of exposure to chemicals handled in the leather tanning industry. MATERIALS AND METHODS--A case-control study was performed within a cohort of 2487 workers employed for at least six months during the period 1900-89 in three Swedish leather tanneries. 68 cancer cases (lung, stomach, bladder, kidney, nasal, and pancreatic cancers and soft tissue sarcomas) and 178 matched controls were studied. Effects of chemical exposures on cancer inci...

  10. Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study

    OpenAIRE

    Paddock Lisa E; Chandran Urmila; King Melony; Bandera Elisa V; Rodriguez-Rodriguez Lorna; Olson Sara H

    2011-01-01

    Abstract Background While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention. Methods We conducted a population-based case-control study to evaluate phytoestrogen intake from foods and supplements and epithelial ovarian cancer risk. Cases were identified in six counties in New Jersey through the New Jersey State Cancer Registry. Controls were identified by random digit dialing, CMS (C...

  11. Designing a community engagement framework for a new dengue control method: a case study from central Vietnam.

    Directory of Open Access Journals (Sweden)

    Darlene McNaughton

    2014-05-01

    Full Text Available BACKGROUND: The Wolbachia strategy aims to manipulate mosquito populations to make them incapable of transmitting dengue viruses between people. To test its efficacy, this strategy requires field trials. Public consultation and engagement are recognized as critical to the future success of these programs, but questions remain regarding how to proceed. This paper reports on a case study where social research was used to design a community engagement framework for a new dengue control method, at a potential release site in central Vietnam. METHODOLOGY/PRINCIPAL FINDINGS: The approach described here, draws on an anthropological methodology and uses both qualitative and quantitative methods to design an engagement framework tailored to the concerns, expectations, and socio-political setting of a potential trial release site for Wolbachia-infected Aedes aegypti mosquitoes. The process, research activities, key findings and how these were responded to are described. Safety of the method to humans and the environment was the most common and significant concern, followed by efficacy and impact on local lives. Residents expected to be fully informed and engaged about the science, the project, its safety, the release and who would be responsible should something go wrong. They desired a level of engagement that included regular updates and authorization from government and at least one member of every household at the release site. CONCLUSIONS/SIGNIFICANCE: Results demonstrate that social research can provide important and reliable insights into public concerns and expectations at a potential release site, as well as guidance on how these might be addressed. Findings support the argument that using research to develop more targeted, engagement frameworks can lead to more sensitive, thorough, culturally comprehensible and therefore ethical consultation processes. This approach has now been used successfully to seek public input and eventually support for

  12. A regulatory framework for shoot stem cell control integrating metabolic, transcriptional, and phytohormone signals.

    Science.gov (United States)

    Schuster, Christoph; Gaillochet, Christophe; Medzihradszky, Anna; Busch, Wolfgang; Daum, Gabor; Krebs, Melanie; Kehle, Andreas; Lohmann, Jan U

    2014-02-24

    Plants continuously maintain pluripotent stem cells embedded in specialized tissues called meristems, which drive long-term growth and organogenesis. Stem cell fate in the shoot apical meristem (SAM) is controlled by the homeodomain transcription factor WUSCHEL (WUS) expressed in the niche adjacent to the stem cells. Here, we demonstrate that the bHLH transcription factor HECATE1 (HEC1) is a target of WUS and that it contributes to SAM function by promoting stem cell proliferation, while antagonizing niche cell activity. HEC1 represses the stem cell regulators WUS and CLAVATA3 (CLV3) and, like WUS, controls genes with functions in metabolism and hormone signaling. Among the targets shared by HEC1 and WUS are phytohormone response regulators, which we show to act as mobile signals in a universal feedback system. Thus, our work sheds light on the mechanisms guiding meristem function and suggests that the underlying regulatory system is far more complex than previously anticipated.

  13. Self-reported chemicals exposure, beliefs about disease causation, and risk of breast cancer in the Cape Cod Breast Cancer and Environment Study: a case-control study

    OpenAIRE

    Rudel Ruthann A; Aschengrau Ann; Zota Ami R; Brody Julia

    2010-01-01

    Abstract Background Household cleaning and pesticide products may contribute to breast cancer because many contain endocrine disrupting chemicals or mammary gland carcinogens. This population-based case-control study investigated whether use of household cleaners and pesticides increases breast cancer risk. Methods Participants were 787 Cape Cod, Massachusetts, women diagnosed with breast cancer between 1988 and 1995 and 721 controls. Telephone interviews asked about product use, beliefs abou...

  14. A mathematical modelling framework for elucidating the role of feedback control in translation termination

    OpenAIRE

    de Silva, Eric; Krishnan, J.; Betney, Russell; Stansfield, Ian

    2010-01-01

    Translation is the final stage of gene expression where messenger RNA is used as a template for protein polymerisation from appropriate amino acids. Release of the completed protein requires a release factor protein acting at the termination/stop codon to liberate it. In this paper we focus on a complex feedback control mechanism involved in the translation and synthesis of release factor proteins, which has been observed in different systems. These release factor proteins are involved in the...

  15. A Framework for Coupling Visual Control and Active Structure from Motion

    OpenAIRE

    Spica, Riccardo; Robuffo Giordano, Paolo; Chaumette, François

    2015-01-01

    International audience In most sensor-based robotic applications, the robot state can only be partially retrieved from onboard sensors and the use of estimation strategies is necessary for recovering online an approximation of any 'missing information' required to accurately control the robot action. With the exception of some trivial cases, however, the relationship between the sensor readings and the robot state is often nonlinear. As a consequence, and regardless of the particular estim...

  16. A TCP/IP framework for ethernet-based measurement, control and experiment data distribution

    Science.gov (United States)

    Ocaya, R. O.; Minny, J.

    2010-11-01

    A complete modular but scalable TCP/IP based scientific instrument control and data distribution system has been designed and realized. The system features an IEEE 802.3 compliant 10 Mbps Medium Access Controller (MAC) and Physical Layer Device that is suitable for the full-duplex monitoring and control of various physically widespread measurement transducers in the presence of a local network infrastructure. The cumbersomeness of exchanging and synchronizing data between the various transducer units using physical storage media led to the choice of TCP/IP as a logical alternative. The system and methods developed are scalable for broader usage over the Internet. The system comprises a PIC18f2620 and ENC28j60 based hardware and a software component written in C, Java/Javascript and Visual Basic.NET programming languages for event-level monitoring and browser user-interfaces respectively. The system exchanges data with the host network through IPv4 packets requested and received on a HTTP page. It also responds to ICMP echo, UDP and ARP requests through a user selectable integrated DHCP and static IPv4 address allocation scheme. The round-trip time, throughput and polling frequency are estimated and reported. A typical application to temperature monitoring and logging is also presented.

  17. Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case–control study

    International Nuclear Information System (INIS)

    The ataxia telangiectasia mutated (ATM) gene is a tumor suppressor gene with functions in cell cycle arrest, apoptosis, and repair of DNA double-strand breaks. Based on family studies, women heterozygous for mutations in the ATM gene are reported to have a fourfold to fivefold increased risk of breast cancer compared with noncarriers of the mutations, although not all studies have confirmed this association. Haplotype analysis has been suggested as an efficient method for investigating the role of common variation in the ATM gene and breast cancer. Five biallelic haplotype tagging single nucleotide polymorphisms are estimated to capture 99% of the haplotype diversity in Caucasian populations. We conducted a nested case–control study of breast cancer within the Nurses' Health Study cohort to address the role of common ATM haplotypes and breast cancer. Cases and controls were genotyped for five haplotype tagging single nucleotide polymorphisms. Haplotypes were predicted for 1309 cases and 1761 controls for which genotype information was available. Six unique haplotypes were predicted in this study, five of which occur at a frequency of 5% or greater. The overall distribution of haplotypes was not significantly different between cases and controls (χ2 = 3.43, five degrees of freedom, P = 0.63). There was no evidence that common haplotypes of ATM are associated with breast cancer risk. Extensive single nucleotide polymorphism detection using the entire genomic sequence of ATM will be necessary to rule out less common variation in ATM and sporadic breast cancer risk

  18. Linking India global health professions student survey data to the world health organization framework convention on tobacco control

    Directory of Open Access Journals (Sweden)

    D N Sinha

    2010-01-01

    Full Text Available The 2003 India Tobacco Control Act (ITCA includes provisions designed to reduce tobacco consumption and protect citizens from exposure to secondhand smoke. India ratified the World Health Organization Framework Convention on Tobacco Control (WHO FCTC on February 27, 2005. The WHO FCTC is the world′s first public health treaty that aims to promote and protect public health and reduce the devastating health and economic impact of tobacco. The Global Health Professions Student Survey (GHPSS was developed to track tobacco use among third-year dental, medical, nursing, and pharmacy students across countries. Data from the dental (2005, medical (2006, nursing(2007, and pharmacy (2008 GHPSS conducted in India showed high prevalence of tobacco use and a general lack of training by health professionals in patient cessation counseling techniques. The Ministry of Health and Family Welfare could use this information to monitor and evaluate the existing tobacco control program effort in India as well as to develop and implement new tobacco control program initiatives.

  19. Circulating C-Reactive Protein Concentrations and Risks of Colon and Rectal Cancer : A Nested Case-Control Study Within the European Prospective Investigation into Cancer and Nutrition

    NARCIS (Netherlands)

    Aleksandrova, Krasimira; Jenab, Mazda; Boeing, Heiner; Jansen, Eugene; Bueno-de-Mesquita, H. Bas; Rinaldi, Sabina; Riboli, Elio; Overvad, Kim; Dahm, Christina C.; Olsen, Anja; Tjonneland, Anne; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Francoise; Morois, Sophie; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Kaaks, Rudolf; Rohrmann, Sabine; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; van Duijnhoven, Fraenzel J. B.; Leufkens, Anke M.; Peeters, Petra H.; Rodriguez, Laudina; Bonet, Catalina; Sanchez, Maria-Jose; Dorronsoro, Miren; Navarro, Carmen; Barricarte, Aurelio; Palmqvist, Richard; Hallmans, Goran; Khaw, Kay-Tee; Wareham, Nicholas; Allen, Naomi E.; Spencer, Elizabeth; Romaguera, Dora; Norat, Teresa; Pischon, Tobias

    2010-01-01

    The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using

  20. A Flexible Spatial Framework for Modeling Spread of Pathogens in Animals with Biosurveillance and Disease Control Applications

    Directory of Open Access Journals (Sweden)

    Montiago X. LaBute

    2014-05-01

    Full Text Available Biosurveillance activities focus on acquiring and analyzing epidemiological and biological data to interpret unfolding events and predict outcomes in infectious disease outbreaks. We describe a mathematical modeling framework based on geographically aligned data sources and with appropriate flexibility that partitions the modeling of disease spread into two distinct but coupled levels. A top-level stochastic simulation is defined on a network with nodes representing user-configurable geospatial “patches”. Intra-patch disease spread is treated with differential equations that assume uniform mixing within the patch. We use U.S. county-level aggregated data on animal populations and parameters from the literature to simulate epidemic spread of two strikingly different animal diseases agents: foot-and-mouth disease and highly pathogenic avian influenza. Results demonstrate the capability of this framework to leverage low-fidelity data while producing meaningful output to inform biosurveillance and disease control measures. For example, we show that the possible magnitude of an outbreak is sensitive to the starting location of the outbreak, highlighting the strong geographic dependence of livestock and poultry infectious disease epidemics and the usefulness of effective biosurveillance policy. The ability to compare different diseases and host populations across the geographic landscape is important for decision support applications and for assessing the impact of surveillance, detection, and mitigation protocols.

  1. A synthesis of evidence on inhibitory control and auditory hallucinations based on the Research Domain Criteria (RDoC framework.

    Directory of Open Access Journals (Sweden)

    Johanna C. Badcock

    2014-03-01

    Full Text Available The National Institute of Mental Health initiative called the Research Domain Criteria (RDoC project aims to provide a new approach to understanding mental illness grounded in the fundamental domains of human behaviour and psychological functioning. To this end the RDoC framework encourages researchers and clinicians to think outside the [diagnostic]box, by studying symptoms, behaviours or biomarkers that cut across traditional mental illness categories. In this article we examine and discuss how the RDoC framework can improve our understanding of psychopathology by zeroing in on hallucinations- now widely recognized as a symptom that occurs in a range of clinical and non-clinical groups. We focus on a single domain of functioning - namely cognitive [inhibitory] control - and assimilate key findings structured around the basic RDoC units of analysis, which span the range from observable behaviour to molecular genetics. Our synthesis and critique of the literature provides a deeper understanding of the mechanisms involved in the emergence of auditory hallucinations, linked to the individual dynamics of inhibitory development before and after puberty; favours separate developmental trajectories for clinical and nonclinical hallucinations; yields new insights into co-occurring emotional and behavioural problems; and suggests some novel avenues for treatment.

  2. Lower Breast Cancer Risk among Women following the World Cancer Research Fund and American Institute for Cancer Research Lifestyle Recommendations: EpiGEICAM Case-Control Study.

    Directory of Open Access Journals (Sweden)

    Adela Castelló

    Full Text Available According to the "World Cancer Research Fund" and the "American Institute of Cancer Research" (WCRF/AICR one in four cancer cases could be prevented through a healthy diet, weight control and physical activity.To explore the association between the WCRF/AICR recommendations and risk of breast cancer.During the period 2006 to 2011 we recruited 973 incident cases of breast cancer and 973 controls from 17 Spanish Regions. We constructed a score based on 9 of the WCRF/AICR recommendations for cancer prevention:: 1Maintain adequate body weight; 2Be physically active; 3Limit the intake of high density foods; 4Eat mostly plant foods; 5Limit the intake of animal foods; 6Limit alcohol intake; 7Limit salt and salt preserved food intake; 8Meet nutritional needs through diet; S1Breastfeed infants exclusively up to 6 months. We explored its association with BC by menopausal status and by intrinsic tumor subtypes (ER+/PR+ & HER2-; HER2+; ER&PR-&HER2- using conditional and multinomial logistic models respectively.Our results point to a linear association between the degree of noncompliance and breast cancer risk. Taking women who met 6 or more recommendations as reference, those meeting less than 3 showed a three-fold excess risk (OR=2.98(CI95%:1.59-5.59, especially for postmenopausal women (OR=3.60(CI95%:1.24;10.47 and ER+/PR+&HER2- (OR=3.60(CI95%:1.84;7.05 and HER2+ (OR=4.23(CI95%:1.66;10.78 tumors. Noncompliance of recommendations regarding the consumption of foods and drinks that promote weight gain in premenopausal women (OR=2.24(CI95%:1.18;4.28; p for interaction=0.014 and triple negative tumors (OR=2.93(CI95%:1.12-7.63; the intake of plant foods in postmenopausal women (OR=2.35(CI95%:1.24;4.44 and triple negative tumors (OR=3.48(CI95%:1.46-8.31; and the alcohol consumption in ER+/PR+&HER2- tumors (OR=1.52 (CI95%:1.06-2.19 showed the strongest associations.Breast cancer prevention might be possible by following the "World Cancer Research Fund" and the

  3. Digitoxin medication and cancer; case control and internal dose-response studies

    Directory of Open Access Journals (Sweden)

    Spigset Olav

    2001-08-01

    Full Text Available Abstract Background Digitoxin induces apoptosis in different human malignant cell lines in vitro. In this paper we investigated if patients taking digitoxin for cardiac disease have a different cancer incidence compared to the general population. Methods Computer stored data on digitoxin concentrations in plasma from 9271 patients with cardiac disease were used to define a user population. Age and sex matched controls from the Norwegian Cancer Registry were used to calculate the number of expected cancer cases. Results The population on digitoxin showed a higher incidence of cancer compared to the control population. However, an additional analysis showed that the population on digitoxin had a general increased risk of cancer already, before the start on digitoxin. Leukemia/lymphoma were the cancer types which stood out with the highest risk in the digitoxin population before starting on digitoxin. This indicates that yet unknown risk factors exist for cardiovascular disease and lymphoproliferative cancer. An internal dose-response analysis revealed a relationship between high plasma concentration of digitoxin and a lower risk for leukemia/lymphoma and for cancer of the kidney/urinary tract. Conclusion Morbidity and mortality are high in the population on digitoxin, due to high age and cardiac disease.These factors disturb efforts to isolate an eventual anticancer effect of digitoxin in this setting. Still, the results may indicate an anticancer effect of digitoxin for leukemia/lymphoma and kidney/urinary tract cancers. Prospective clinical cancer trials have to be done to find out if digitoxin and other cardiac glycosides are useful as anticancer agents.

  4. A Pre-Clinical Framework for Neural Control of a Therapeutic Upper-Limb Exoskeleton

    OpenAIRE

    Blank, Amy; O’Malley, Marcia K.; Francisco, Gerard E; Contreras-Vidal, Jose L.

    2013-01-01

    In this paper, we summarize a novel approach to robotic rehabilitation that capitalizes on the benefits of patient intent and real-time assessment of impairment. Specifically, an upper-limb, physical human-robot interface (the MAHI EXO-II robotic exoskeleton) is augmented with a non-invasive brain-machine interface (BMI) to include the patient in the control loop, thereby making the therapy ‘active’ and engaging patients across a broad spectrum of impairment severity in the rehabilitation tas...

  5. A Domain-specific Framework for Automated Construction and Verification of Railway Control Systems

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth

    2009-01-01

    elaborate safety mechanisms in order to keep the risk at the same low level that has been established for European railways until today. The challenge is further increased by the demand for shorter time-to-market periods and higher competition among suppliers of the railway domain; both factors resulting in...... a demand for a higher degree of automation for the development verification, validation and test phases of projects, without impairing the thoroughness of safety-related quality measures and certification activities. Motivated by these considerations, this presentation describes an approach for...... automated construction and verification of railway control systems....

  6. A Possible Association between Melanoma and Prostate Cancer. Results from a Case-Control-Study

    Directory of Open Access Journals (Sweden)

    Alina Goldenberg

    2015-04-01

    Full Text Available Melanoma and prostate cancer are the fifth and first most common cancers in men within the United States, respectively. The association between the two cancers lies in the mutual androgen-dependence. However, the relationship between prostate cancer history and melanoma development remains to be further elucidated. We aim to determine the odds of history of prostate cancer among men with melanoma as compared to time-frame, clinic, and provider-matched controls without melanoma within a single academic surgical center. We present a case-control study comparing men treated for melanoma and non-melanoma cancer by a single provider between 2010 and 2014 within an academic dermatologic surgical center. Overall, there were nine cases of prostate cancer among the melanoma group and two cases amongst the controls—a statistically significant difference in both uni- and multivariable analyses (p = 0.057 [95% CI 1, 23.5], p = 0.042 [95% CI 1.1, 129], respectively. Body mass index, alcohol use, and skin type II were significant risk factors for melanoma (p = 0.011 [95% CI 1, 1.3], 0.005 [95% CI 1.4, 7], 0.025 [95% CI 1.1, 3.3], respectively. There were more immunosuppressed controls (p = 0.002; however, the melanoma patients had a significantly longer duration of immunosuppression (11.6 vs. 1.9 years, p < 0.001 [95% CI 0.03, 0.5]. Melanoma screenings for men should include questions on prostate cancer history. Prostate cancer patients may benefit from more frequent and comprehensive melanoma screening.

  7. Curcumin: a Polyphenol with Molecular Targets for Cancer Control.

    Science.gov (United States)

    Qadir, Muhammad Imran; Naqvi, Syeda Tahira Qousain; Muhammad, Syed Aun

    2016-01-01

    Curcumin, is a polyphenol from Curcuma longa (turmeric plant), is a polyphenol that belongs to the ginger family which has long been used in Ayurveda medicines to treat various diseases such as asthma, anorexia, coughing, hepatic diseases, diabetes, heart diseases, wound healing and Alzheimer's. Various studies have shown that curcumin has anti-infectious, anti-inflammatory, anti-oxidant, hepatoprotective, thrombosuppressive, cardio protective, anti-arthritic, chemo preventive and anti-carcinogenic activities. It may suppress both initiation and progression stages of cancer. Anticancer activity of curcumin is due to negative regulation of inflammatory cytokines, transcription factors, protein kinases, reactive oxygen species (ROS) and oncogenes. This review focuses on the different targets of curcumin to treat cancer. PMID:27356682

  8. Population-based case-control study of breast cancer in Albania

    Directory of Open Access Journals (Sweden)

    Pajenga E.

    2013-01-01

    Full Text Available In Albania, breast cancer is an important cause of death among women, with increasing incidence from 65 cases in 1970, to 400 cases in 2007. This is the first study concerning breast cancer risk factors in Albania. We used a population-based case-control study of 948 women with breast cancer compared with 1019 controls recruited from other hospitals through random selection. Early age at menarche was found to be a significantly strong risk factor during the pre- and postmenopausal groups with OR 10.04 and 12.1, respectively. In addition, nulliparity is associated with higher risk while abortion did not indicate any influence in the multivariate model. The findings from this study have shown that reproductive and menstrual variables are significant predictors of breast cancer risk in Albanian women, as seen in studies of other western countries.

  9. Control of cancer growth using single input autonomous fuzzy Nano-particles

    Directory of Open Access Journals (Sweden)

    Fahimeh Razmi

    2015-04-01

    Full Text Available In this paper a single input fuzzy controller is applied on autonomous drug-encapsulated nanoparticles (ADENPs to restrict the cancer growth. The proposed ADENPs, swarmly release the drug in local cancerous tissue and effectively decreases the destruction of normal tissue. The amount of released drug is defined considering to feed backed values of tumor growth rate and the used drug. Some significant characteristics of Nano particles compared to Nano-robots is their ability to recognize the cancerous tissue from the normal one and their simple structure. Nano particles became an attractive topic in Nano science and many efforts have been done to manufacture these particles. Simulation results show that the proposed controlling method not only decreases the cancerous tissue effectively but also reduces the side effects of drug impressively.

  10. Modelling lymphatic filariasis transmission and control: modelling frameworks, lessons learned and future directions.

    Science.gov (United States)

    Stolk, Wilma A; Stone, Chris; de Vlas, Sake J

    2015-03-01

    Mathematical modelling provides a useful tool for policy making and planning in lymphatic filariasis control programmes, by providing trend forecasts based on sound scientific knowledge and principles. This is now especially true, in view of the ambitious target to eliminate lymphatic filariasis as a public health problem globally by the year 2020 and the short remaining timeline to achieve this. To meet this target, elimination programmes need to be accelerated, requiring further optimization of strategies and tailoring to local circumstances. Insights from epidemiological transmission models provide a useful basis. Two general models of lymphatic filariasis transmission and control are nowadays in use to support decision-making, namely a population-based deterministic model (EPIFIL) and an individual-based stochastic model (LYMFASIM). Model predictions confirm that lymphatic filariasis transmission can be interrupted by annual mass drug administration (MDA), but this may need to be continued much longer than the initially suggested 4-6 years in areas with high transmission intensity or poor treatment coverage. However, the models have not been validated against longitudinal data describing the impact of MDA programmes. Some critical issues remain to be incorporated in one or both of the models to make predictions on elimination more realistic, including the possible occurrence of systematic noncompliance, the risk of emerging parasite resistance to anthelmintic drugs, and spatial heterogeneities. Rapid advances are needed to maximize the utility of models in decision-making for the ongoing ambitious lymphatic filariasis elimination programmes.

  11. Modelling lymphatic filariasis transmission and control: modelling frameworks, lessons learned and future directions.

    Science.gov (United States)

    Stolk, Wilma A; Stone, Chris; de Vlas, Sake J

    2015-03-01

    Mathematical modelling provides a useful tool for policy making and planning in lymphatic filariasis control programmes, by providing trend forecasts based on sound scientific knowledge and principles. This is now especially true, in view of the ambitious target to eliminate lymphatic filariasis as a public health problem globally by the year 2020 and the short remaining timeline to achieve this. To meet this target, elimination programmes need to be accelerated, requiring further optimization of strategies and tailoring to local circumstances. Insights from epidemiological transmission models provide a useful basis. Two general models of lymphatic filariasis transmission and control are nowadays in use to support decision-making, namely a population-based deterministic model (EPIFIL) and an individual-based stochastic model (LYMFASIM). Model predictions confirm that lymphatic filariasis transmission can be interrupted by annual mass drug administration (MDA), but this may need to be continued much longer than the initially suggested 4-6 years in areas with high transmission intensity or poor treatment coverage. However, the models have not been validated against longitudinal data describing the impact of MDA programmes. Some critical issues remain to be incorporated in one or both of the models to make predictions on elimination more realistic, including the possible occurrence of systematic noncompliance, the risk of emerging parasite resistance to anthelmintic drugs, and spatial heterogeneities. Rapid advances are needed to maximize the utility of models in decision-making for the ongoing ambitious lymphatic filariasis elimination programmes. PMID:25765197

  12. 75 FR 57472 - Breast and Cervical Cancer Early Detection and Control Advisory Committee (BCCEDCAC): Notice of...

    Science.gov (United States)

    2010-09-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Breast and Cervical Cancer Early Detection and Control Advisory Committee (BCCEDCAC): Notice of Charter Renewal This gives notice under the...

  13. Oral cancer prevention and control--the approach of the World Health Organization

    DEFF Research Database (Denmark)

    Petersen, Poul Erik

    2009-01-01

    Cancer is one of the most common causes of morbidity and mortality today. It is estimated that around 43% of cancer deaths are due to tobacco use, unhealthy diets, alcohol consumption, inactive lifestyles and infection. Low-income and disadvantaged groups are generally more exposed to avoidable r...... diagnosis and treatment;--The WHO Global Oral Health Programme will use this statement as the lead for its work for oral cancer control www.who.int/oral_health....... approaches in prevention and health promotion, and the development of global surveillance systems for oral cancer and risk factors. The WHO Global Oral Health Programme has established a global surveillance system of oral cavity cancer in order to assess risk factors and to help the planning of effective...... prevention. The resolution WHA60 A16 URGES Member states--To take steps to ensure that prevention of oral cancer is an integral part of national cancer-control programmes, and to involve oral-health professionals or primary health care personnel with relevant training in oral health in detection, early...

  14. Urinary bladder cancer risk factors in men: a Spanish case-control study.

    Science.gov (United States)

    Baena, Antonio Varo; Allam, Mohamed Farouk; Del Castillo, Amparo Serrano; Díaz-Molina, Carmen; Requena Tapia, Maria José; Abdel-Rahman, Amira Gamal; Navajas, Rafael Fernández-Crehuet

    2006-12-01

    The rising incidence of urinary bladder cancer is alarming and potential relationships with different risk factors have been postulated. The purpose of this study was to examine the possible relationship between different environmental risk factors and urinary bladder cancer. All men with urinary bladder cancer who were admitted to the Department of Urology of Reina Sofia University Hospital of Cordoba, Spain over 1 year were included in our study. Men were administered an interview questionnaire, which included data on history of known urinary bladder cancer risk factors. Comparisons between men with urinary bladder cancer (cases) and those with nonmalignant urological disease (controls) were made. The study included 74 cases and 89 controls. The variables associated with malignant lesions on univariate analysis were age, smoking and drinking alcohol. Meanwhile, fish, poultry and beef consumption were proved to be protective factors. The risk factors identified by the logistic regression analysis were age, smoking and fluid intake. The independent protective factors on the multivariate analysis were fish and poultry consumptions. Smoking was found to be the principal independent risk factors for urinary bladder cancer. Our results call for further investigation of urinary bladder cancer risk factors; future studies should preferably be performed on large prospective cohorts, to increase their validity. PMID:17106329

  15. Molecular characterization of the stomach microbiota in patients with gastric cancer and controls

    Energy Technology Data Exchange (ETDEWEB)

    Dicksved, J.; Lindberg, M.; Rosenquist, M.; Enroth, H.; Jansson, J.K.; Engstrand, L.

    2009-01-15

    Persistent infection of the gastric mucosa by Helicobacter pylori, can initiate an inflammatory cascade that progresses into atrophic gastritis, a condition associated with reduced capacity for secretion of gastric acid and an increased risk in developing gastric cancer. The role of H. pylori as an initiator of inflammation is evident but the mechanism for development into gastric cancer has not yet been proven. A reduced capacity for gastric acid secretion allows survival and proliferation of other microbes that normally are killed by the acidic environment. It has been postulated that some of these species may be involved in the development of gastric cancer, however their identities are poorly defined. In this study, the gastric microbiota from ten patients with gastric cancer was characterized and compared with five dyspeptic controls using the molecular profiling approach, terminal-restriction fragment length polymorphism (T-RFLP), in combination with 16S rRNA gene cloning and sequencing. T-RFLP analysis revealed a complex bacterial community in the cancer patients that was not significantly different from the controls. Sequencing of 140 clones revealed 102 phylotypes, with representatives from five bacterial phyla (Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria and Fusobacteria). The data revealed a relatively low abundance of H. pylori and showed that the gastric cancer microbiota was instead dominated by different species of the genera Streptococcus, Lactobacillus, Veillonella and Prevotella. The respective role of these species in development of gastric cancer remains to be determined.

  16. Controllable formation of heterotrimetallic coordination compounds: systematically incorporating lanthanide and alkali metal ions into the manganese 12-metallacrown-4 framework.

    Science.gov (United States)

    Azar, Michael R; Boron, Thaddeus T; Lutter, Jacob C; Daly, Connor I; Zegalia, Kelcie A; Nimthong, Ruthairat; Ferrence, Gregory M; Zeller, Matthias; Kampf, Jeff W; Pecoraro, Vincent L; Zaleski, Curtis M

    2014-02-01

    The inclusion of Ln(III) ions into the 12-MC-4 framework generates the first heterotrimetallic complexes of this molecular class. The controllable and deliberate preparations of these compounds are demonstrated through 12 crystal structures of the Ln(III)M(I)(OAc)4[12-MCMn(III)(N)shi-4](H2O)4·6DMF complex, where OAc(-) is acetate, shi(3-) is salicylhydroximate, and DMF is N,N-dimethylformamide. Compounds 1-12 have M(I) as Na(I), and Ln(III) can be Pr(III) (1), Nd(III) (2), Sm(III) (3), Eu(III) (4), Gd(III) (5), Tb(III) (6), Dy(III) (7), Ho(III) (8), Er(III) (9), Tm(III) (10), Yb(III) (11), and Y(III) (12). An example with M(I) = K(I) and Ln(III) = Dy(III) is also reported (Dy(III)K(OAc)4[12-MCMn(III)(N)shi-4](DMF)4·DMF (14)). When La(III), Ce(III), or Lu(III) is used as the Ln(III) ions to prepare the Ln(III)Na(I)(OAc)4[12-MCMn(III)(N)shi-4] complex, the compound Na2(OAc)2[12-MCMn(III)(N)shi-4](DMF)6·2DMF·1.60H2O (13) results. For compounds 1-12, the identity of the Ln(III) ion affects the 12-MCMn(III)(N)shi-4 framework as the largest Ln(III), Pr(III), causes an expansion of the 12-MCMn(III)(N)shi-4 framework as demonstrated by the largest metallacrown cavity radius (0.58 Å for 1 to 0.54 Å for 11), and the Pr(III) causes the 12-MCMn(III)(N)shi-4 framework to be the most domed structure as evident in the largest average angle about the axial coordination of the ring Mn(III) ions (103.95° for 1 to 101.69° for 11). For 14, the substitution of K(I) for Na(I) does not significantly affect the 12-MCMn(III)(N)shi-4 framework as many of the structural parameters such as the metallacrown cavity radius (0.56 Å) fall within the range of compounds 1-12. However, the use of the larger K(I) ion does cause the 12-MCMn(III)(N)shi-4 framework to become more planar as evident in a smaller average angle about the axial coordination of the ring Mn(III) ions (101.35°) compared to the analogous Dy(III)/Na(I) (7) complex (102.40°). In addition to broadening the range of

  17. Bra wearing not associated with breast cancer risk: a population based case-control study

    OpenAIRE

    Chen, Lu; Malone, Kathleen E.; Li, Christopher I.

    2014-01-01

    Despite the widespread use of bras among U.S. women and concerns in the lay media that bra wearing may increase breast cancer risk, there is a scarcity of credible scientific studies addressing this issue. The goal of the study was to evaluate the relationship between various bra wearing habits and breast cancer risk among postmenopausal women. We conducted a population-based case-control study of breast cancer in the Seattle-Puget Sound metropolitan area that compared 454 invasive ductal car...

  18. Computation of eigenvalue sensitivity to base flow modifications in a discrete framework: Application to open-loop control

    CERN Document Server

    Mettot, Clément; Sipp, Denis

    2014-01-01

    A fully discrete formalism is introduced to perform stability analysis of a turbulent compressible flow whom dynamics is modeled with the Reynolds-Averaged Navier-Stokes (RANS) equations. The discrete equations are linearized using finite differences and the Jacobian is computed using repeated evaluation of the residuals. Stability of the flow is assessed solving an eigenvalue problem. The sensitivity gradients which indicate regions of the flow where a passive control device could stabilize the unstable eigenvalues are defined within this fully discrete framework. Second order finite differences are applied to the discrete residual to compute the gradients. In particular, the sensitivity gradients are shown to be linked to the Hessian of the RANS equations. The introduced formalism and linearization method are generic: the code used to evaluate the residual of the RANS equations can be used in a black box manner, and the complex linearization of the Hessian is avoided. The method is tested on a two dimension...

  19. Nanoparticle Cookies Derived from Metal-Organic Frameworks: Controlled Synthesis and Application in Anode Materials for Lithium-Ion Batteries.

    Science.gov (United States)

    Wang, Shuhai; Chen, Minqi; Xie, Yanyu; Fan, Yanan; Wang, Dawei; Jiang, Ji-Jun; Li, Yongguang; Grützmacher, Hansjörg; Su, Cheng-Yong

    2016-05-01

    The capacity of anode materials plays a critical role in the performance of lithium-ion batteries. Using the nanocrystals of oxygen-free metal-organic framework ZIF-67 as precursor, a one-step calcination approach toward the controlled synthesis of CoO nanoparticle cookies with excellent anodic performances is developed in this work. The CoO nanoparticle cookies feature highly porous structure composed of small CoO nanoparticles (≈12 nm in diameter) and nitrogen-rich graphitic carbon matrix (≈18 at% in nitrogen content). Benefiting from such unique structure, the CoO nanoparticle cookies are capable of delivering superior specific capacity and cycling stability (1383 mA h g(-1) after 200 runs at 100 mA g(-1) ) over those of CoO and graphite.

  20. COMPUTER-ASSISTED CONTROL OF ACADEMIC PERFORMANCE IN ENGINEERING GRAPHICS WITHIN THE FRAMEWORK OF DISTANCE LEARNING PROGRAMMES

    Directory of Open Access Journals (Sweden)

    Tel'noy Viktor Ivanovich

    2012-10-01

    Full Text Available Development of computer-assisted computer technologies and their integration into the academic activity with a view to the control of the academic performance within the framework of distance learning programmes represent the subject matter of the article. The article is a brief overview of the software programme designated for the monitoring of the academic performance of students enrolled in distance learning programmes. The software is developed on Delphi 7.0 for Windows operating system. The strength of the proposed software consists in the availability of the two modes of its operation that differ in the principle of the problem selection and timing parameters. Interim academic performance assessment is to be performed through the employment of computerized testing procedures that contemplate the use of a data base of testing assignments implemented in the eLearning Server media. Identification of students is to be performed through the installation of video cameras at workplaces of students.

  1. Local-regional control in breast cancer patients with a possible genetic predisposition

    International Nuclear Information System (INIS)

    Purpose: Local control rates for breast cancer in genetically predisposed women are poorly defined. Because such a small percentage of breast cancer patients have proven germline mutations, surrogates, such as a family history for breast cancer, have been used to examine this issue. The purpose of this study was to evaluate local-regional control following breast conservation therapy (BCT) in patients with bilateral breast cancer and a breast cancer family history. Methods and Materials: We retrospectively reviewed records of all 58 patients with bilateral breast cancer and a breast cancer family history treated in our institution between 1959 and 1998. The primary surgical treatment was a breast-conserving procedure in 55 of the 116 breast cancer cases and a mastectomy in 61. The median follow-up was 68 months for the BCT patients and 57 months for the mastectomy-treated patients. Results: Eight local-regional recurrences occurred in the 55 cases treated with BCT, resulting in 5- and 10-year actuarial local-regional control rates of 86% and 76%, respectively. In the nine cases that did not receive radiation as a component of their BCT, four developed local-regional recurrences (5- and 10-year local-regional control rates of BCT without radiation: 49% and 49%). The 5- and 10-year actuarial local-regional control rates for the 46 cases treated with BCT and radiation were 94% and 83%, respectively. In these cases, there were two late local recurrences, developing at 8 years and 9 years, respectively. A log rank comparison of radiation versus no radiation actuarial data was significant at p = 0.009. In the cases treated with BCT, a multivariate analysis of radiation use, patient age, degree of family history, margin status, and stage revealed that only the use of radiation was associated with improved local control (Cox regression analysis p = 0.021). The 10-year actuarial rates of local-regional control following mastectomy with and without radiation were 91% and 89

  2. Columnar cell lesions and subsequent breast cancer risk: a nested case-control study

    OpenAIRE

    Aroner, Sarah A.; Collins, Laura Christine; Schnitt, Stuart Jay; Connolly, James Leo; Colditz, Graham A; Tamimi, Rulla May

    2010-01-01

    Introduction: Histologic and genetic evidence suggests that at least some columnar cell lesions (CCL) of the breast represent precursor lesions in the low-grade breast neoplasia pathway. However, the risk of subsequent breast cancer associated with the presence of CCL in a benign breast biopsy is poorly understood.Methods The authors examined the association between the presence of CCL and subsequent breast cancer risk in a nested case-control study of benign breast disease (BBD) and breast c...

  3. Performance of cancer cluster Q-statistics for case-control residential histories

    OpenAIRE

    Sloan, Chantel D.; Jacquez, Geoffrey M; Gallagher, Carolyn M.; Ward, Mary H; Raaschou-Nielsen, Ole; Nordsborg, Rikke Baastrup; Meliker, Jaymie R.

    2012-01-01

    Few investigations of health event clustering have evaluated residential mobility, though causative exposures for chronic diseases such as cancer often occur long before diagnosis. Recently developed Q-statistics incorporate human mobility into disease cluster investigations by quantifying space- and time-dependent nearest neighbor relationships. Using residential histories from two cancer case-control studies, we created simulated clusters to examine Q-statistic performance. Results suggest ...

  4. Intentions to use Hypnosis to Control the Side Effects of Cancer and its Treatment

    OpenAIRE

    Sohl, Stephanie J.; Stossel, Lauren; Schnur, Julie B.; Tatrow, Kristin; Gherman, Amfiana; Montgomery, Guy H.

    2010-01-01

    Evidence suggests that hypnosis is an effective intervention for reducing distress, pain and other side effects associated with cancer and its treatment. However, hypnosis has failed to be adopted into standard clinical practice. This study (n=115) investigated overall intentions to use hypnosis to control side effects of cancer and its treatment, as well as demographic predictors of such intentions among healthy volunteers. Results suggest that the vast majority of patients (89%) would be wi...

  5. Cigarette smoking and risk of ovarian cancer: a pooled analysis of 21 case-control studies

    OpenAIRE

    Faber, Mette T.; Kjær, Susanne K.; Dehlendorff, Christian; Chang-Claude, Jenny; Klaus K. Andersen; Høgdall, Estrid; Webb, Penelope M.; Jordan, Susan J; Rossing, Mary Anne; Doherty, Jennifer A; Lurie, Galina; Pamela J Thompson; Carney, Michael E; Goodman, Marc T.; Ness, Roberta B.

    2013-01-01

    Purpose The majority of previous studies have observed an increased risk of mucinous ovarian tumors associated with cigarette smoking, but the association with other histological types is unclear. In a large pooled analysis, we examined the risk of epithelial ovarian cancer associated with multiple measures of cigarette smoking with a focus on characterizing risks according to tumor behavior and histology. Methods We used data from 21 case–control studies of ovarian cancer (19,066...

  6. Stress/strain Modelling of Casting Processes in the Framework of the Control-Volume Method

    DEFF Research Database (Denmark)

    Hattel, Jesper Henri; Thorborg, Jesper; Andersen, Søren

    1998-01-01

    Realistic computer simulations of casting processes call for the solution of both thermal, fluid-flow and stress/strain related problems. The multitude of the influencing parameters, and their non-linear, transient and temperature dependent nature, make the calculations complex. Therefore the need...... domain, which is highly convenient. The basis of the method is the control volume finite difference approach on structured meshes. The basic assumptions of the method are shortly reviewed and discussed. As for other methods which aim at application oriented analysis of casting deformations and stresses......, the present model is based on the mainly decoupled representation of the thermal, mechanical and microstructural processes. Examples of industrial applications, such as predicting residual deformations in castings and stress levels in die casting dies, are presented...

  7. Effect of Tumor Infiltrating Lymphocyte on Local Control of Rectal Cancer after Preoperative Radiotherapy

    Institute of Scientific and Technical Information of China (English)

    XU Gang; XU Bo; ZHANG Shan-wen

    2008-01-01

    Objective:To study the effect of tumor infiltrating lymphocytes at cancer nest on local control of rectal cancer after preoperative radiotherapy.Methods:From Jan.1999 to Oct.2007,a total of 107 patients with rectal cancer were reviewed.They were treated by preoperative radiotherapy,30 Gy/10 fractions/12 days.Two weeks later,the patient underwent a surgical operation.Their pathological samples were kept in our hospital before and after radiotherapy.Lymphocyte infiltration(LI)degree,pathologic degradation and fibrosis degree after radiotherapy in paraffin section were evaluated under microscope.Results:After followed-up of 21 months(2-86 months),a total of 107 patients were reviewed.Univariate analysis showed that lymphocyte infiltration(LI),fibrosis and pathologic changes after radiotherapy were significant factors on local control.Logistic regression analysis showed that LI after radiotherapy was a significant effect factor on local control.Conclusion:LI,fibrosis and pathologic degradation after radiotherapy are significant for local control of rectal cancer after preoperative radiotherapy.LI after radiotherapy was a significantly prognostic index for local control of rectal cancer after preoperative radiotherapy.

  8. Negative impact of pretreatment anemia on local control after neoadjuvant chemoradiotherapy and surgery for rectal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hye Bin; Park, Hee Chul; Park, Won [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); and others

    2012-09-15

    Although anemia is considered to be a contributor to intra-tumoral hypoxia and tumor resistance to ionizing radiation in cancer patients, the impact of pretreatment anemia on local control after neoadjuvant concurrent chemoradiotherapy (NACRT) and surgery for rectal cancer remains unclear. We reviewed the records of 247 patients with locally advanced rectal cancer who were treated with NACRT followed by curative-intent surgery. The patients with anemia before NACRT (36.0%, 89/247) achieved less pathologic complete response (pCR) than those without anemia (p = 0.012). The patients with pretreatment anemia had worse 3-year local control than those without pretreatment anemia (86.0% vs. 95.7%, p = 0.005). Multivariate analysis showed that pretreatment anemia (p = 0.035), pathologic tumor and nodal stage (p = 0.020 and 0.032, respectively) were independently significant factors for local control. Pretreatment anemia had negative impacts on pCR and local control among patients who underwent NACRT and surgery for rectal cancer. Strategies maintaining hemoglobin level within normal range could potentially be used to improve local control in rectal cancer patients.

  9. Living with prostate cancer: randomised controlled trial of a multimodal supportive care intervention for men with prostate cancer

    Directory of Open Access Journals (Sweden)

    Lepore Stephen

    2011-07-01

    Full Text Available Abstract Background Prostate cancer is the most common male cancer in developed countries and diagnosis and treatment carries with it substantial morbidity and related unmet supportive care needs. These difficulties may be amplified by physical inactivity and obesity. We propose to apply a multimodal intervention approach that targets both unmet supportive care needs and physical activity. Methods/design A two arm randomised controlled trial will compare usual care to a multimodal supportive care intervention "Living with Prostate Cancer" that will combine self-management with tele-based group peer support. A series of previously validated and reliable self-report measures will be administered to men at four time points: baseline/recruitment (when men are approximately 3-6 months post-diagnosis and at 3, 6, and 12 months after recruitment and intervention commencement. Social constraints, social support, self-efficacy, group cohesion and therapeutic alliance will be included as potential moderators/mediators of intervention effect. Primary outcomes are unmet supportive care needs and physical activity levels. Secondary outcomes are domain-specific and health-related quality of life (QoL; psychological distress; benefit finding; body mass index and waist circumference. Disease variables (e.g. cancer grade, stage will be assessed through medical and cancer registry records. An economic evaluation will be conducted alongside the randomised trial. Discussion This study will address a critical but as yet unanswered research question: to identify a population-based way to reduce unmet supportive care needs; promote regular physical activity; and improve disease-specific and health-related QoL for prostate cancer survivors. The study will also determine the cost-effectiveness of the intervention. Trial Registration ACTRN12611000392965

  10. Cancer epidemiology and control in peninsular and island South-East Asia - past, present and future.

    Science.gov (United States)

    Moore, Malcolm A; Manan, Azizah Ab; Chow, Khuan Yew; Cornain, Santoso F; Devi, C R Beena; Triningsih, F X Ediati; Laudico, Adriano; Mapua, Cynthia A; Mirasol-Lumague, Maria Rica; Noorwati, S; Nyunt, Kan; Othman, Nor Hayati; Shah, Shamsul Azhar; Sinuraya, Evlina Suzanna; Yip, Cheng Har; Sobue, Tomotaka

    2010-01-01

    Malaysia, Brunei, Singapore, Indonesia, East Timor and the Philippines constitute peninsular and island South-East Asia. For reasons of largely shared ethnicity, with Chinese elements added to the basic Austromalaysian populations, as well as geographical contiguity, they can be usefully grouped together for studies of chronic disease prevalence and underlying risk factors. The fact of problems are shared in common, particularly regarding increasing cancer rates, underlines the necessity for a coordinated approach to research and development of control measures. To provide a knowledge base, the present review of available data for cancer registration, epidemiology and control was conducted. The most prevalent cancer site in males is the lung, followed by the liver, colon or the prostate in the majority of cases, while breast and cervical cancers predominate in most female populations. However, there are interesting differences among the racial groups, particularly regarding the stomach. General tendencies for increase in adenocarcinomas but decrease in squamous cell carcinomas and gastric cancer, point to change in environmental influence over time. Variation in risk factors depends to some extent on the level of economic development but overall the countries of the region face similar challenges in achieving effective cancer control. A major task is persuading the general populace of the efficacy of early detection and clinical treatment. PMID:20553070

  11. Lympho-vascular invasion in BRCA related breast cancer compared to sporadic controls

    Directory of Open Access Journals (Sweden)

    van der Wall Elsken

    2010-04-01

    Full Text Available Abstract Background Germline mutations in the BRCA1 gene predispose to the development of breast cancer, exhibiting a specific histological phenotype. Identification of possible hallmarks of these tumors is important for selecting patients for genetic screening and provides inside in carcinogenetic pathways. Since BRCA1-associated breast cancers have pushing borders that prevent them from easily reaching vessels and are often of the medullary (like type that is known to have a low rate of lympho-vascular invasion (LVI, we hypothesized that absence of LVI could characterize BRCA1 related breast cancer. Methods A population of 68 BRCA1 related invasive breast cancers was evaluated for LVI by an experienced breast pathologist blinded to mutation status, and compared to a control group matched for age, grade and tumor type. Results LVI was present in 25.0% of BRCA1 related cases, compared to 20.6% of controls (P = 0.54, OR = 1.29, CI 0.58-2.78. Conclusion LVI is frequent in BRCA1 germline mutation related breast cancers, but seems to occur as often in sporadic controls matched for age, grade and tumor type. Apparently, these hereditary cancers find their way to the blood and lymph vessels despite their well demarcation and often medullary differentiation.

  12. Modeling Intercellular Communication as a Survival Strategy of Cancer Cells: An In Silico Approach on a Flexible Bioinformatics Framework

    Science.gov (United States)

    Cárdenas-García, Maura; González-Pérez, Pedro P.; Montagna, Sara; Cortés, Oscar Sánchez; Caballero, Elena Hernández

    2016-01-01

    Intercellular communication is very important for cell development and allows a group of cells to survive as a population. Cancer cells have a similar behavior, presenting the same mechanisms and characteristics of tissue formation. In this article, we model and simulate the formation of different communication channels that allow an interaction between two cells. This is a first step in order to simulate in the future processes that occur in healthy tissue when normal cells surround a cancer cell and to interrupt the communication, thus preventing the spread of malignancy into these cells. The purpose of this study is to propose key molecules, which can be targeted to allow us to break the communication between cancer cells and surrounding normal cells. The simulation is carried out using a flexible bioinformatics platform that we developed, which is itself based on the metaphor chemistry-based model. PMID:26997867

  13. ReACP: A Semi-Automated Framework for Reverse-engineering and Testing of Access Control Policies of Web Applications

    OpenAIRE

    Le, Ha Thanh; Nguyen, Duy Cu; Briand, Lionel

    2016-01-01

    This technical report details our a semi-automated framework for the reverse-engineering and testing of access control (AC) policies for web-based applications. In practice, AC specifications are often missing or poorly documented, leading to AC vulnerabilities. Our goal is to learn and recover AC policies from implementation, and assess them to find AC issues. Built on top of a suite of security tools, our framework automatically explores a system under test, mines domain input specification...

  14. Lung cancer risk, exposure to radon and tobacco consumption in a nested case-control study of French uranium miners

    International Nuclear Information System (INIS)

    Introduction: A nested case-control study was conducted among the French uranium miners cohort in order to assess the effect of protract ed radon exposure on lung cancer risk taking into account tobacco consumption. Material and methods: One hundred uranium miners employed by the French company CEA-COGEMA and who died of a lung cancer between 1980 and 1994 were identified as cases among the cohort. For each case, five controls were randomly matched on birth period and attained age at the time of death of the corresponding case. Cumulated radon exposure during employment was reconstructed for each of these 100 cases and 500 controls. Smoking habits were retrospectively determined from three complementary sources: 1) medical files, 2) forms filled in by occupational physicians and 3) questionnaires applied in face-to-face interviews, phone calls or mailings. Analysis was performed by conditional logistic regression using a linear excess relative risk (ERR) model. A multiplicative model was fitted to assess the joint effect of radon exposure and smoking on lung cancer risk. Results: Smoking status was established for 62 cases and 320 controls and two categories ('ever smokers' vs. 'never smokers') were defined. Ninety percent of the cases and 73% of the controls were classified as 'ever smokers'. Mean five-year lagged cumulated radon exposures were 82.0 and 47.6 working level months (WLM) for the cases and the controls, respectively. The excess relative risk per WLM (ERR/WLM) was 1.1% with a 95%-confidence interval (CI) of 0.2-2.0%. When adjusting for smoking, radon exposure effect was little modified (ERR/WLM = 0.8%, 95% -CI = 0.1- 2.8%). The effect of smoking on lung cancer risk was comparable to results reported in previous miners cohorts (OR = 3.04, 95% -CI = 1.20-7.70). Discussion: A consequent effort was carried out to collect smoking status from three sources for the miners included in this nested case-control study. This analysis shows that, when adjusting on

  15. Controlled Redox Chemistry at Cerium within a Tripodal Nitroxide Ligand Framework.

    Science.gov (United States)

    Bogart, Justin A; Lippincott, Connor A; Carroll, Patrick J; Booth, Corwin H; Schelter, Eric J

    2015-12-01

    Ligand reorganization has been shown to have a profound effect on the outcome of cerium redox chemistry. Through the use of a tethered, tripodal, trianionic nitroxide ligand, [((2-tBuNOH)C6 H4 CH2 )3 N](3-) (TriNOx (3-) ), controlled redox chemistry at cerium was accomplished, and typically reactive complexes of tetravalent cerium were isolated. These included rare cationic complexes [Ce(TriNOx )thf][BAr(F) 4 ], in which Ar(F) =3,5-(CF3 )2 -C6 H3 , and [Ce(TriNOx )py][OTf]. A rare complete Ce-halide series, Ce(TriNOx )X, in which X=F(-) , Cl(-) , Br(-) , I(-) , was also synthesized. The solution chemistry of these complexes was explored through detailed solution-phase electrochemistry and (1) H NMR experiments and showed a unique shift in the ratio of species with inner- and outer-sphere anions with size of the anionic X(-) group. DFT calculations on the series of calculations corroborated the experimental findings.

  16. A Pre-Clinical Framework for Neural Control of a Therapeutic Upper-Limb Exoskeleton.

    Science.gov (United States)

    Blank, Amy; O'Malley, Marcia K; Francisco, Gerard E; Contreras-Vidal, Jose L

    2013-01-01

    In this paper, we summarize a novel approach to robotic rehabilitation that capitalizes on the benefits of patient intent and real-time assessment of impairment. Specifically, an upper-limb, physical human-robot interface (the MAHI EXO-II robotic exoskeleton) is augmented with a non-invasive brain-machine interface (BMI) to include the patient in the control loop, thereby making the therapy 'active' and engaging patients across a broad spectrum of impairment severity in the rehabilitation tasks. Robotic measures of motor impairment are derived from real-time sensor data from the MAHI EXO-II and the BMI. These measures can be validated through correlation with widely used clinical measures and used to drive patient-specific therapy sessions adapted to the capabilities of the individual, with the MAHI EXO-II providing assistance or challenging the participant as appropriate to maximize rehabilitation outcomes. This approach to robotic rehabilitation takes a step towards the seamless integration of BMIs and intelligent exoskeletons to create systems that can monitor and interface with brain activity and movement. Such systems will enable more focused study of various issues in development of devices and rehabilitation strategies, including interpretation of measurement data from a variety of sources, exploration of hypotheses regarding large scale brain function during robotic rehabilitation, and optimization of device design and training programs for restoring upper limb function after stroke. PMID:24887296

  17. A Pre-Clinical Framework for Neural Control of a Therapeutic Upper-Limb Exoskeleton.

    Science.gov (United States)

    Blank, Amy; O'Malley, Marcia K; Francisco, Gerard E; Contreras-Vidal, Jose L

    2013-01-01

    In this paper, we summarize a novel approach to robotic rehabilitation that capitalizes on the benefits of patient intent and real-time assessment of impairment. Specifically, an upper-limb, physical human-robot interface (the MAHI EXO-II robotic exoskeleton) is augmented with a non-invasive brain-machine interface (BMI) to include the patient in the control loop, thereby making the therapy 'active' and engaging patients across a broad spectrum of impairment severity in the rehabilitation tasks. Robotic measures of motor impairment are derived from real-time sensor data from the MAHI EXO-II and the BMI. These measures can be validated through correlation with widely used clinical measures and used to drive patient-specific therapy sessions adapted to the capabilities of the individual, with the MAHI EXO-II providing assistance or challenging the participant as appropriate to maximize rehabilitation outcomes. This approach to robotic rehabilitation takes a step towards the seamless integration of BMIs and intelligent exoskeletons to create systems that can monitor and interface with brain activity and movement. Such systems will enable more focused study of various issues in development of devices and rehabilitation strategies, including interpretation of measurement data from a variety of sources, exploration of hypotheses regarding large scale brain function during robotic rehabilitation, and optimization of device design and training programs for restoring upper limb function after stroke.

  18. Hamilton-Jacobi-Bellman framework for optimal control in multistage energy systems

    Science.gov (United States)

    Sieniutycz, Stanislaw

    2000-03-01

    We enunciate parallelism for structures of variational principles in mechanics and thermodynamics in terms of the duality for thermoeconomic problems of maximizing of production profit and net profit which can be transferred to duality for least action and least abbreviated action which appear in mechanics. With the parallelism in mind, we review theory and macroscopic applications of a recently developed discrete formalism of Hamilton-Jacobi type which arises when Bellman's method of dynamic programming is applied to optimize active (work producing) and inactive (entropy generating) multistage energy systems with free intervals of an independent variable. Our original contribution develops a generalized theory for discrete processes in which these intervals can reside in the model inhomogeneously and can be constrained. We consider applications to multistage thermal machines, controlled unit operations, spontaneous relaxations, nonlinear heat conduction, and self-propagating reaction-diffusion fronts. They all satisfy a basic functional equation that leads to the Hamilton-Jacobi-Bellman equation (HJB equation) and a related discrete optimization algorithm with a maximum principle for a Hamiltonian. Correspondence is shown with the well-known HJB theory for continuous processes when the number of stages approaches an infinity. We show that a common unifying criterion, which is the criterion of a minimum generated entropy, can be proven to act locally in the majority of considered cases, although the related global statements can be invalid far from equilibrium. General limits are found which bound the consumption of the classical work potential (exergy) for finite durations.

  19. Disentangling the Association between Statins, Cholesterol, and Colorectal Cancer: A Nested Case-Control Study

    Science.gov (United States)

    Mamtani, Ronac; Lewis, James D.; Scott, Frank I.; Ahmad, Tariq; Goldberg, David S.; Datta, Jashodeep; Yang, Yu-Xiao; Boursi, Ben

    2016-01-01

    Background Several prior studies have found an association between statin use and reduced risk of colorectal cancer. We hypothesized that these findings may be due to systematic bias and examined the independent association of colorectal cancer risk with statin use, serum cholesterol, and change in cholesterol concentration. Methods and Findings 22,163 colorectal cancer cases and 86,538 matched controls between 1995 and 2013 were identified within The Health Improvement Network (THIN) a population-representative database. Conditional logistic regression models estimated colorectal cancer risk with statin use, serum total cholesterol (mmol/L), and change in total cholesterol level. We confirmed a decreased risk of colorectal cancer with statin use (long-term: odds ratio [OR], 0.95; 95% confidence interval [CI], 0.91–0.99; short-term: OR, 0.92; 95% CI, 0.85–0.99). However, to assess whether the observed association may result from indication bias, a subgroup analysis was conducted among patients prescribed a statin. In this subgroup (n = 5,102 cases, n = 19,032 controls), 3.1% of case subjects and 3.1% of controls discontinued therapy. The risk of colorectal cancer was not significantly different among those who continued statin therapy and those who discontinued (OR, 0.98; 95% CI, 0.79–1.22). Increased serum cholesterol was independently associated with decreased risk of colorectal cancer (OR, 0.89 per mmol/L increase; 95% CI, 0.87–0.91); the association was only present if serum cholesterol was measured near the cancer diagnosis (24 mo: OR, 0.98; 95% CI, 0.93–1.03). Decreases in serum total cholesterol >1 mmol/L ≥1 year prior to cancer diagnosis were associated with subsequent colorectal cancer (statin users: OR, 1.25; 95 CI%, 1.03–1.53; nonusers: OR, 2.36; 95 CI%, 1.78–3.12). As an observational study, limitations included incomplete data and residual confounding. Conclusions Although the risk of colorectal cancer was lower in statin users versus

  20. An investigation of breast cancer risk factors in Cyprus: a case control study

    Directory of Open Access Journals (Sweden)

    Hadjisavvas Andreas

    2010-08-01

    Full Text Available Abstract Background Breast cancer is the most common form of malignancy affecting women worldwide. It is also the leading cancer in females in Cyprus, with approximately 400 new cases diagnosed annually. It is well recognized that genetic variation as well as environmental factors modulate breast cancer risk. The main aim of this study was to assess the strength of associations between recognized risk factors and breast cancer among Cypriot women. This is the first epidemiological investigation on risk factors of breast cancer among the Cypriot female population. Methods We carried out a case-control study, involving 1,109 breast cancer patients and a group of 1,177 controls who were recruited while participating in the National screening programme for breast cancer. Information on demographic characteristics and potential risk factors were collected from both groups during a standardized interview. Logistic regression analysis was used to assess the strength of the association between each risk factor and breast cancer risk, before and after adjusting for the possible confounding effect of other factors. Results In multivariable models, family history of breast cancer (OR 1.64, 95% CI 1.23, 2.19 was the strongest predictor of breast cancer risk in the Cypriot population. Late menarche (OR 0.64, 95% CI 0.45, 0.92 among women reaching menarche after the age of 15 vs. before the age of 12 and breastfeeding (OR 0.74, 95% CI 0.59, 0.92 exhibited a strong protective effect. In the case of breastfeeding, the observed effect appeared stronger than the effect of pregnancy alone. Surprisingly, we also observed an inverse association between hormone replacement therapy (HRT although this may be a product of the retrospective nature of this study. Conclusion Overall the findings of our study corroborate with the results of previous investigations on descriptive epidemiology of risk factors for breast cancer. This investigation provides important background

  1. Breast cancer risk and drinking water contaminated by wastewater: a case control study

    Directory of Open Access Journals (Sweden)

    Swartz Christopher H

    2006-10-01

    Full Text Available Abstract Background Drinking water contaminated by wastewater is a potential source of exposure to mammary carcinogens and endocrine disrupting compounds from commercial products and excreted natural and pharmaceutical hormones. These contaminants are hypothesized to increase breast cancer risk. Cape Cod, Massachusetts, has a history of wastewater contamination in many, but not all, of its public water supplies; and the region has a history of higher breast cancer incidence that is unexplained by the population's age, in-migration, mammography use, or established breast cancer risk factors. We conducted a case-control study to investigate whether exposure to drinking water contaminated by wastewater increases the risk of breast cancer. Methods Participants were 824 Cape Cod women diagnosed with breast cancer in 1988–1995 and 745 controls who lived in homes served by public drinking water supplies and never lived in a home served by a Cape Cod private well. We assessed each woman's exposure yearly since 1972 at each of her Cape Cod addresses, using nitrate nitrogen (nitrate-N levels measured in public wells and pumping volumes for the wells. Nitrate-N is an established wastewater indicator in the region. As an alternative drinking water quality indicator, we calculated the fraction of recharge zones in residential, commercial, and pesticide land use areas. Results After controlling for established breast cancer risk factors, mammography, and length of residence on Cape Cod, results showed no consistent association between breast cancer and average annual nitrate-N (OR = 1.8; 95% CI 0.6 – 5.0 for ≥ 1.2 vs. Conclusion Results did not provide evidence of an association between breast cancer and drinking water contaminated by wastewater. The computer mapping methods used in this study to link routine measurements required by the Safe Drinking Water Act with interview data can enhance individual-level epidemiologic studies of multiple health

  2. Relationship between Selected Socio-Demographic Factors and Cancer of Oral Cavity - A Case Control Study.

    Science.gov (United States)

    Madani, Abdoul Hossain; Dikshit, Madhurima; Bhaduri, Debanshu; Jahromi, Abdolreza Sotoodeh; Aghamolaei, Teamur

    2010-08-11

    The aim of this study was to recognize factors associated with cancer of oral cavity considering socio-demographic characteristics. The cases were 350 with squamous-cell carcinoma of oral cavity diagnosed between 2005 and 2006 in Morbai, Narandia, Budharani Cancer Institute, Pune, India. Similar number of controls match for age and sex selected from the background population. Cases and controls were interviewed for tobacco related habits and general characteristics; age, gender, education and possible socio-demographic factors. Chi-square test in uni-variate analysis and estimate for risk showed that education, occupation and monthly household income were significantly different between cases and controls (P currency (OR = 1.7, CI 1.2-2.3) were significant risk factors for oral cancer. While, there was no significant relationship between religious and or marital status either in males or females.

  3. Fruit and vegetable consumption and lung cancer risk: a case-control study in Galicia, Spain.

    Science.gov (United States)

    Tarrazo-Antelo, Ana Marina; Ruano-Ravina, Alberto; Abal Arca, José; Barros-Dios, Juan Miguel

    2014-01-01

    Lung cancer has multiple risk factors and tobacco is the main one. Diet plays a role, but no clear effect has been consistently observed for different fruit and vegetable consumption. We aim to assess the association between fruit and vegetable consumption and lung cancer risk through a hospital-based case-control study in Spanish population. We recruited incident lung cancer cases in 2 Spanish hospitals from 2004 to 2008. Controls were individuals attending hospital for trivial surgery. Cases and controls were older than 30 and did not have a neoplasic history. We collected information on lifestyle with special emphases on tobacco and dietary habits. We included 371 cases and 496 controls. We found no protective effect for overall fruit consumption. For green leafy vegetables, the odds ratio (OR) was 0.92 [95% confidence interval (CI) = 0.32-2.69), and for other vegetables the OR was 0.77 (95% CI = 0.40-1.48) for the categories compared. We observed a reduced risk for broccoli and pumpkin intake. Although fruit consumption does not seem to be associated with a lower lung cancer risk, only the frequent consumption of specific green leafy vegetables and other vegetables might be associated with a reduced risk of lung cancer.

  4. Genetic analysis of the vitamin D receptor gene in two epithelial cancers: melanoma and breast cancer case-control studies

    International Nuclear Information System (INIS)

    Vitamin D serum levels have been found to be related to sun exposure and diet, together with cell differentiation, growth control and consequently, cancer risk. Vitamin D receptor (VDR) genotypes may influence cancer risk; however, no epidemiological studies in sporadic breast cancer (BC) or malignant melanoma (MM) have been performed in a southern European population. In this study, the VDR gene has been evaluated in two epithelial cancers BC and MM. We have conducted an analysis in 549 consecutive and non-related sporadic BC cases and 556 controls, all from the Spanish population, and 283 MM cases and 245 controls. Genotyping analyses were carried out on four putatively functional SNPs within the VDR gene. An association with the minor allele A of the non-synonymous SNP rs2228570 (rs10735810, FokI, Met1Thr) was observed for BC, with an estimated odds ratio (OR) of 1.26 (95% CI = 1.02–1.57; p = 0.036). The synonymous variant rs731236 (TaqI) appeared to be associated with protection from BC (OR = 0.80, 95%CI = 0.64–0.99; p = 0.047). No statistically significant associations with MM were observed for any SNP. Nevertheless, sub-group analyses revealed an association between rs2228570 (FokI) and absence of childhood sunburns (OR = 0.65, p = 0.003), between the 3'utr SNP rs739837 (BglI) and fair skin (OR = 1.31, p = 0.048), and between the promoter SNP rs4516035 and the more aggressive tumour location in head-neck and trunk (OR = 1.54, p = 0.020). In summary, we observed associations between SNPs in the VDR gene and BC risk, and a comprehensive analysis using clinical and tumour characteristics as outcome variables has revealed potential associations with MM. These associations required confirmation in independent studies

  5. Fish pass assessment by remote control: a novel framework for quantifying the hydraulics at fish pass entrances

    Science.gov (United States)

    Kriechbaumer, Thomas; Blackburn, Kim; Gill, Andrew; Breckon, Toby; Everard, Nick; Wright, Ros; Rivas Casado, Monica

    2014-05-01

    Fragmentation of aquatic habitats can lead to the extinction of migratory fish species with severe negative consequences at the ecosystem level and thus opposes the target of good ecological status of rivers defined in the EU Water Framework Directive (WFD). In the UK, the implementation of the EU WFD requires investments in fish pass facilities of estimated 532 million GBP (i.e. 639 million Euros) until 2027 to ensure fish passage at around 3,000 barriers considered critical. Hundreds of passes have been installed in the past. However, monitoring studies of fish passes around the world indicate that on average less than half of the fish attempting to pass such facilities are actually successful. There is a need for frameworks that allow the rapid identification of facilities that are biologically effective and those that require enhancement. Although there are many environmental characteristics that can affect fish passage success, past research suggests that variations in hydrodynamic conditions, reflected in water velocities, velocity gradients and turbulences, are the major cues that fish use to seek migration pathways in rivers. This paper presents the first steps taken in the development of a framework for the rapid field-based quantification of the hydraulic conditions downstream of fish passes and the assessment of the attractivity of fish passes for salmonids and coarse fish in UK rivers. For this purpose, a small-sized remote control platform carrying an acoustic Doppler current profiler (ADCP), a GPS unit, a stereo camera and an inertial measurement unit has been developed. The large amount of data on water velocities and depths measured by the ADCP within relatively short time is used to quantify the spatial and temporal distribution of water velocities. By matching these hydraulic features with known preferences of migratory fish, it is attempted to identify likely migration routes and aggregation areas at barriers as well as hydraulic features that

  6. Invasive meningococcal disease epidemiology and control measures: a framework for evaluation

    Directory of Open Access Journals (Sweden)

    Coudeville L

    2007-06-01

    Full Text Available Abstract Background Meningococcal disease can have devastating consequences. As new vaccines emerge, it is necessary to assess their impact on public health. In the absence of long-term real world data, modeling the effects of different vaccination strategies is required. Discrete event simulation provides a flexible platform with which to conduct such evaluations. Methods A discrete event simulation of the epidemiology of invasive meningococcal disease was developed to quantify the potential impact of implementing routine vaccination of adolescents in the United States with a quadrivalent conjugate vaccine protecting against serogroups A, C, Y, and W-135. The impact of vaccination is assessed including both the direct effects on individuals vaccinated and the indirect effects resulting from herd immunity. The simulation integrates a variety of epidemiologic and demographic data, with core information on the incidence of invasive meningococcal disease and outbreak frequency derived from data available through the Centers for Disease Control and Prevention. Simulation of the potential indirect benefits of vaccination resulting from herd immunity draw on data from the United Kingdom, where routine vaccination with a conjugate vaccine has been in place for a number of years. Cases of disease are modeled along with their health consequences, as are the occurrence of disease outbreaks. Results When run without a strategy of routine immunization, the simulation accurately predicts the age-specific incidence of invasive meningococcal disease and the site-specific frequency of outbreaks in the Unite States. 2,807 cases are predicted annually, resulting in over 14,000 potential life years lost due to invasive disease. In base case analyses of routine vaccination, life years lost due to infection are reduced by over 45% (to 7,600 when routinely vaccinating adolescents 12 years of age at 70% coverage. Sensitivity analyses indicate that herd immunity plays

  7. Mathematically modelling and controlling prostate cancer under intermittent hormone therapy

    Institute of Scientific and Technical Information of China (English)

    Yoshito Hirata; Gouhei Tanaka; Nicholas Bruchovsky; Kazuyuki Aihara

    2012-01-01

    In this review,we summarize our recently developed mathematical models that predict the effects of intermittent androgen suppression therapy on prostate cancer (PCa).Although hormone therapy for PCa shows remarkable results at the beginning of treatment,cancer cells frequently acquire the ability to grow without androgens during long-term therapy,resulting in an eventual relapse.To circumvent hormone resistance,intermittent androgen suppression was investigated as an alternative treatment option.However,at the present time,it is not possible to select an optimal schedule of on- and off-treatment cycles for any given patient.In addition,clinical trials have revealed that intermittent androgen suppression is effective for some patients but not for others.To resolve these two problems,we have developed mathematical models for PCa under intermittent androgen suppression.The mathematical models not only explain the mechanisms of intermittent androgen suppression but also provide an optimal treatment schedule for the on- and off-treatment periods.

  8. Coffee consumption and the risk of endometrial cancer: Evidence from a case-control study of female hormone-related cancers in Japan.

    Science.gov (United States)

    Hirose, Kaoru; Niwa, Yoshimitsu; Wakai, Kenji; Matsuo, Keitaro; Nakanishi, Toru; Tajima, Kazuo

    2007-03-01

    Coffee has become a popular beverage worldwide. Caffeine, a major ingredient of coffee, has been proposed to have a favorable affect on the modulation of circulating estrogen levels and therefore may be of importance in developments on hormone-related cancers. However, epidemiological evidence is limited and inconsistent. We examined the relationship between intake of coffee and hormone-related cancer risk among Japanese women using data from the hospital-based epidemiological research program at Aichi Cancer Center (HERPACC). In total, 2122 breast, 229 endometrial and 166 ovarian cancer cases were included, and 12 425 women, confirmed as free of cancer, were recruited as the control group. Odds ratios (OR) and 95% confidence intervals (95% CI) were determined by multiple logistic regression analysis. A statistically significant inverse association between risk of endometrial cancer and coffee consumption was noted in Japanese women, with no clear association evident for breast and ovarian cancer risk. Compared to non-drinker, the OR of daily drinking of 1-2 cups and 3 or more cups per day for endometrial cancer were 0.64 (95% CI: 0.43-0.94) and 0.41 (95% CI: 0.19-0.87), respectively, and the linear trend was also statistically significant (P cancer. In summary, the results of the present study suggest that coffee consumption reduces the risk of endometrial cancer in Japanese subjects. Given the scarcity of studies of coffee intake and endometrial cancer and other hormone-dependent cancer risk, additional investigations are warranted. PMID:17270030

  9. Mass screening-based case-control study of diet and prostate cancer in Changchun, China

    Institute of Scientific and Technical Information of China (English)

    Xiao-Meng Li; Jiang Li; Ichiro Tsuji; Naoki Nakaya; Yoshikazu Nishino; Xue-Jian Zhao

    2008-01-01

    Aim: To investigate possible correlation factors for prostate cancer by a population-based case-control study in China. Methods: We carded out a mass screening of prostate cancer in Changchun, China, using a prostate-specific antigen assisted by Japan International Cooperation Agency. From June 1998 to December 2000, 3 940 men over 50 years old were screened. Of these, 29 men were diagnosed with prostate cancer. We selected 28 cases and matched them with controls of low prostate-specific antigen value (< 4.1 ng/mL) by 1:10 according to age and place of employment. A case-control study of diet and prostate cancer was then carded out. Results: After adjustment for education, body mass index (BMI), smoking, alcohol consumption, marriage and diet, intake of soybean product was discovered to be inversely related to prostate cancer. Men who consumed soybean product more than twice per week on different days had a multivariate odds ratio (OR) of 0.38 (95% confidence interval [CI], 0.13-1.12). In addition, men who consumed soybean products more than once per day had a multivariate OR of 0.29 (95% CI, 0.11-0.79) compared with men who consumed soybean products less than once per week. The P for trend was 0.02, which showed significant difference. There was no significant difference in P trend for any dairy food. Even when we matched the cases and controls by other criteria, we found that soybean food was the only preventive factor associated with prostate cancer. Conclusion: Our study suggests that consumption of soybeans, one of the most popular foods in Asia, would decrease the risk of prostate cancer. (Asian J Androl 2008 Jul; 10: 551-560)

  10. A case-control study of lung cancer in Polish women

    Energy Technology Data Exchange (ETDEWEB)

    Rachtan, J. [M Sklodowska Curie Member Institute, Krakow (Poland)

    2002-07-01

    This study was undertaken to examine the influence of active and passive smoking, cancer family history, occupational exposure, usual diet and alcohol consumption on female lung cancer risk. A total of 242 women with histologically confirmed primary lung cancer and 352 healthy controls were involved in the study. All subjects were interviewed in the hospital. Data were analysed using multivariate logistic regression. Multivariate analysis has shown that smoking was the most strongly active risk factor in female lung cancer, Positive dose-response relationship was observed between lung cancer risk and number of pack-years. Passive smoking exposure during childhood significantly increased the risk (OR=2.65). There was also observed a significantly increased risk of lung cancer among women who had siblings with history of cancer (OR=3.42). Occupational exposure to coal dust, acid fumes (sulphuric and/or hydrochloric) and materials used for rubber making significantly increased the risk. Frequent intake of carrots (at least five times a week) and also daily intake of other vegetables significantly lowered the risk (OR=0.13, OR=0.24). A significant protective effect was also observed in women frequently using margarine on bread (OR=0.14). Vodka drinkers showed significantly higher risk than non-drinking women. The analysis of dose-response relationship in reference to vodka drinking, also confirmed significant influence of this factor on the risk.

  11. Multiscale Modelling of Cancer Progression and Treatment Control: The Role of Intracellular Heterogeneities in Chemotherapy Treatment

    Science.gov (United States)

    Chaplain, Mark A. J.; Powathil, Gibin G.

    Cancer is a complex, multiscale process involving interactions at intracellular, intercellular and tissue scales that are in turn susceptible to microenvironmental changes. Each individual cancer cell within a cancer cell mass is unique, with its own internal cellular pathways and biochemical interactions. These interactions contribute to the functional changes at the cellular and tissue scale, creating a heterogenous cancer cell population. Anticancer drugs are effective in controlling cancer growth by inflicting damage to various target molecules and thereby triggering multiple cellular and intracellular pathways, leading to cell death or cell-cycle arrest. One of the major impediments in the chemotherapy treatment of cancer is drug resistance driven by multiple mechanisms, including multi-drug and cell-cycle mediated resistance to chemotherapy drugs. In this article, we discuss two hybrid multiscale modelling approaches, incorporating multiple interactions involved in the sub-cellular, cellular and microenvironmental levels to study the effects of cell-cycle, phase-specific chemotherapy on the growth and progression of cancer cells.

  12. Skin Cancer Control Western Australia: Is it Working and What Have we Learned?

    Energy Technology Data Exchange (ETDEWEB)

    Slevin, T.; Clarkson, J.; English, D

    2000-07-01

    Australia has the highest rates of skin cancer in the world, with malignant melanoma rates in Western Australia second only to the state of Queensland. The Cancer Foundation of Western Australia has been actively involved in skin cancer control programmes for almost 20 years. The evaluation of skin cancer campaigns run by the Foundation over the past 5 years, including evaluation data from the summer 1998/99 campaign, is reported. Secondly, the reduction of age standardised rates of melanoma now being witnessed in Western Australia are reported. From these data arises the question - is it too early to claim that public health measures have contributed to this recent reduction in melanoma rates in Western Australia? Finally, a summary is presented of lessons learned about the historical process of conducting skin cancer control programmes. While there is debate about the specific impact in terms of skin cancer incidence rates, there is no doubt our programmes have changed the way Australians perceive, and behave, in the sun. (author)

  13. Skin Cancer Control Western Australia: Is it Working and What Have we Learned?

    International Nuclear Information System (INIS)

    Australia has the highest rates of skin cancer in the world, with malignant melanoma rates in Western Australia second only to the state of Queensland. The Cancer Foundation of Western Australia has been actively involved in skin cancer control programmes for almost 20 years. The evaluation of skin cancer campaigns run by the Foundation over the past 5 years, including evaluation data from the summer 1998/99 campaign, is reported. Secondly, the reduction of age standardised rates of melanoma now being witnessed in Western Australia are reported. From these data arises the question - is it too early to claim that public health measures have contributed to this recent reduction in melanoma rates in Western Australia? Finally, a summary is presented of lessons learned about the historical process of conducting skin cancer control programmes. While there is debate about the specific impact in terms of skin cancer incidence rates, there is no doubt our programmes have changed the way Australians perceive, and behave, in the sun. (author)

  14. Symbiosis of zeolite-like metal-organic frameworks (rho-ZMOF) and hydrogels: Composites for controlled drug release

    KAUST Repository

    Ananthoji, Ramakanth

    2011-01-01

    The design and synthesis of new finely tunable porous materials has spurred interest in developing novel uses in a variety of systems. Zeolites, inorganic materials with high thermal and mechanical stability, in particular, have been widely examined for use in applications such as catalysis, ion exchange and separation. A relatively new class of inorganic-organic hybrid materials known as metal-organic frameworks (MOFs) have recently surfaced, and many have exhibited their efficiency in potential applications such as ion exchange and drug delivery. A more recent development is the design and synthesis of a subclass of MOFs based on zeolite topologies (i.e. ZMOFs), which often exhibit traits of both zeolites and MOFs. Bio-compatible hydrogels already play an important role in drug delivery systems, but are often limited by stability issues. Thus, the addition of ZMOFs to hydrogel formulations is expected to enhance the hydrogel mechanical properties, and the ZMOF-hydrogel composites should present improved, symbiotic drug storage and release for delivery applications. Herein we present the novel composites of a hydrogel with a zeolite-like metal-organic framework, rho-ZMOF, using 2-hydroxyethyl methacrylate (HEMA), 2,3-dihydroxypropyl methacrylate (DHPMA), N-vinyl-2-pyrolidinone (VP) and ethylene glycol dimethacrylate (EGDMA), and the corresponding drug release. An ultraviolet (UV) polymerization method is employed to synthesize the hydrogels, VP 0, VP 15, VP 30, VP 45 and the ZMOF-VP 30 composite, by varying the VP content (mol%). The rho-ZMOF, VP 30, and ZMOF-VP 30 composite are all tested for the controlled release of procainamide (protonated, PH), an anti-arrhythmic drug, in phosphate buffer solution (PBS) using UV spectroscopy. © 2011 The Royal Society of Chemistry.

  15. Implementation of the World Health Organization Framework Convention on Tobacco Control in China: An arduous and long-term task.

    Science.gov (United States)

    Xiao, Dan; Bai, Chun-Xue; Chen, Zheng-Ming; Wang, Chen

    2015-09-01

    China is the largest producer and consumer of tobacco in the world. Consequently, the burden of tobacco-related diseases in China is enormous. Implementation of the World Health Organization Framework Convention on Tobacco Control (WHO FCTC) may lead to a significant reduction in tobacco-related morbidity and mortality both in China and globally. In this review, the authors summarize the epidemic of tobacco use and the progress made in implementing the WHO FCTC, including the promotion of legislation for smoke-free public places; smoking-cessation assistance; labeling of tobacco packaging; enforcement of bans on tobacco advertising, promotion, and sponsorship; increased taxes on tobacco products; increased tobacco prices; improvements in public awareness of the dangers of smoking; and identifying the barriers to implementing effective tobacco-control measures in China. Since the WHO FCTC officially took effect in China on January 9, 2006, China has taken some important steps, especially in promoting legislation for smoke-free public places. Because tobacco permeates the fabric of society, business, commerce, and politics in China, commitments and actions from the government are crucial, and implementing the WHO FCTC in China will be an arduous and long-term task.

  16. The Framework Convention on Tobacco Control, ten years later: the regulatory function of OMS to the rescue of global health?

    Directory of Open Access Journals (Sweden)

    KASTLER, Florian

    2016-06-01

    Full Text Available This article analyzes the implementation of the Framework Convention on Tobacco Control (FCTC ten years after its entry into force in 2005, when it was received as a binding legal healthy, innovative and international, instrument. Considered as a symptom of the strong normative function of the World Health Organization (WHO, in accordance with Article 19 of its Constitution, the FCTC could respond to the expectation to become an example to be followed in the creation of new legal instruments of global health. After analyzing the influence of the Convention in national legal systems and its impact on the health of individuals, this article examines the elements that contributed to its approval and the continuing difficulties for its implementation. The analysis shows that if the results in the fight against smoking are promising, based on the experience of the FCTC, some lessons were learned: first, to improve the monitoring and control system to implement the Convention; and second, to consider new ambitious instruments in other areas of health. It seems that these instruments should be adapted to the specific contexts of each health challenge. More generally, in the context of reform, this article demonstrates that the proper use of the normative function offers a response to the criticism being made to WHO, questioning its legitimacy and credibility as an institution focused on global health.

  17. PRM:A Resource Management Framework for Policy-driven QoS Control in Enhanced Internets

    Institute of Scientific and Technical Information of China (English)

    FU Xiaoming; ZHANG Yaoxue

    2001-01-01

    The Internet has evolved from a tra-ditional best-effort delivery data network into an en-hanced Internet that can provide a certain Qualityof Service(QoS) mechanisms for applications.How-ever,these QoS mechanisms usually do not take policyfactors into account such as priority and time-of-day.The paper presents a Resource Management Frame-work for Policy-driven QoS control (PRM) in en-hanced internets,which consists of four components:Domain Policy Controller(DPC) resides an adminis-trator domain,Border Resource Manager(BRM) re-sides between adjacent domains,Interior ResourceManagers(IRM) in each router between two BRMswithin the same domain,and Endsystem ResourceManager(ERM) in charge of end-node/host router re-sources.We first introduce challenges and demandsfacing the enhanced internets,then give a formalizeddefinition of policy and describe the functions and in-teraction of components of PRM.Specifically we takeQoS-pricing policy used in a Diff-Serv environmentas an example to illustrate the operational phases of PRM.

  18. Preoperative radiotherapy for rectal cancer: a comparative study of quality control adherence at two cancer hospitals in Spain and Poland

    International Nuclear Information System (INIS)

    We performed a clinical audit of preoperative rectal cancer treatment at two European radiotherapy centres (Poland and Spain). The aim was to independently verify adherence to a selection of indicators of treatment quality and to identify any notable inter-institutional differences. A total of 162 patients, in Catalan Institute of Oncology (ICO) 68 and in Greater Poland Cancer Centre (GPCC) 94, diagnosed with locally advanced rectal cancer and treated with preoperative radiotherapy or radio-chemotherapy were included in retrospective study. A total of 7 quality control measures were evaluated: waiting time, multidisciplinary treatment approach, portal verification, in vivo dosimetry, informed consent, guidelines for diagnostics and therapy, and patient monitoring during treatment. Several differences were observed. Waiting time from pathomorphological diagnosis to initial consultation was 31 (ICO) vs. 8 (GPCC) days. Waiting time from the first visit to the beginning of the treatment was twice as long at the ICO. At the ICO, 82% of patient experienced treatment interruptions. The protocol for portal verification was the same at both institutions. In vivo dosimetry is not used for this treatment localization at the ICO. The ICO utilizes locally-developed guidelines for diagnostics and therapy, while the GPCC is currently developing its own guidelines. An independent external clinical audit is an excellent approach to identifying and resolving deficiencies in quality control procedures. We identified several procedures amenable to improvement. Both institutions have since implemented changes to improve quality standards. We believe that all radiotherapy centres should perform a comprehensive clinical audit to identify and rectify deficiencies

  19. Challenges in the development and implementation of the National Comprehensive Cancer Control Program in Mexico.

    Science.gov (United States)

    Reynoso-Noverón, Nancy; Meneses-García, Abelardo; Erazo-Valle, Aura; Escudero-de Los Ríos, Pedro; Kuri-Morales, Pablo Antonio; Mohar-Betancourt, Alejandro

    2016-04-01

    Chronic noncommunicable diseases (NCDs), including cancer, have become the leading cause of human morbidity and mortality. In Mexico, cancer is the third leading cause of death, with a high incidence among the economically active population, a high proportion of advanced stages at diagnosis and limited care coverage for patients. However, no public policy aimed at managing this important public health problem has been developed and implemented to date. This manuscript describes the first interinstitutional proposal of a National Program for Cancer Control, considering the known risk factors, early detection, treatment, palliative care and patient rehabilitation. This manuscript also outlines a series of thoughts on the difficulties and needs that the Mexican health system faces in achieving the main objectives of the program: to decrease the incidence of cancer, to increase survival and to improve the quality of life for this group of patients. PMID:27557393

  20. The post hoc use of randomised controlled trials to explore drug associated cancer outcomes

    DEFF Research Database (Denmark)

    Stefansdottir, Gudrun; Zoungas, Sophia; Chalmers, John;

    2013-01-01

    on public health before proper regulatory action can be taken. This paper aims to discuss challenges of exploring drug-associated cancer outcomes by post-hoc analyses of Randomised controlled trials (RCTs) designed for other purposes. METHODOLOGICAL CHALLENGES TO CONSIDER: We set out to perform a post......INTRODUCTION: Drug-induced cancer risk is of increasing interest. Both observational studies and data from clinical trials have linked several widely used treatments to cancer. When a signal for a potential drug-cancer association is generated, substantiation is required to assess the impact...... challenges must be addressed to enhance the likelihood of reliable conclusions. Advantages of post-hoc analyses of RCTs include quality of data collected and sometimes randomisation to exposure of interest. Limitations include confounding and sample size, which is fixed to suit the purposes of the trial...