WorldWideScience

Sample records for cancer advocacy changing

  1. Bladder Cancer Advocacy Network

    Science.gov (United States)

    ... future bladder cancer research through the Patient Survey Network. Read More... The JPB Foundation 2016 Bladder Cancer ... 2016 Young Investigator Awardees The Bladder Cancer Advocacy Network (BCAN) has announced the recipients of the 2016 ...

  2. Patient Education vs. Patient Experiences of Self-advocacy: Changing the Discourse to Support Cancer Survivors.

    Science.gov (United States)

    Hagan, Teresa L; Medberry, Elizabeth

    2016-06-01

    A growing emphasis on patient self-advocacy has emerged in the public discourse on cancer survivorship. This discourse shapes patients' conceptualizations about self-advocacy and in turn influences their health care attitudes and behaviors. The purpose of this discourse analysis is to explore the language of self-advocacy by comparing a published self-advocacy guide with the lived experiences of women with ovarian cancer. Data sources include (1) a self-advocacy patient education guide published by the National Coalition for Cancer Survivorship and (2) transcripts of focus groups conducted with ovarian cancer survivors. Discourse analysis techniques were used to take a close look at the language used by both to uncover the meaning each group ascribed to self-advocacy. Challenges and inconsistencies were noted between the patient education guide and transcripts including viewing self-advocacy as a skill set to assert one's needs as opposed to a means by which to preserve a positive attitude and maintain a trusting relationship with health care providers, respectively. Some women saw themselves as self-advocates yet struggled to locate relevant health information and hesitated to upset their relationship with their health care providers. This analysis highlights tensions between the discourses and points to ways in which patient education materials can be adjusted to support cancer survivors in advocating for their needs according to their unique situations and preferences. PMID:25846573

  3. Patient Education vs. Patient Experiences of Self-advocacy: Changing the Discourse to Support Cancer Survivors.

    Science.gov (United States)

    Hagan, Teresa L; Medberry, Elizabeth

    2016-06-01

    A growing emphasis on patient self-advocacy has emerged in the public discourse on cancer survivorship. This discourse shapes patients' conceptualizations about self-advocacy and in turn influences their health care attitudes and behaviors. The purpose of this discourse analysis is to explore the language of self-advocacy by comparing a published self-advocacy guide with the lived experiences of women with ovarian cancer. Data sources include (1) a self-advocacy patient education guide published by the National Coalition for Cancer Survivorship and (2) transcripts of focus groups conducted with ovarian cancer survivors. Discourse analysis techniques were used to take a close look at the language used by both to uncover the meaning each group ascribed to self-advocacy. Challenges and inconsistencies were noted between the patient education guide and transcripts including viewing self-advocacy as a skill set to assert one's needs as opposed to a means by which to preserve a positive attitude and maintain a trusting relationship with health care providers, respectively. Some women saw themselves as self-advocates yet struggled to locate relevant health information and hesitated to upset their relationship with their health care providers. This analysis highlights tensions between the discourses and points to ways in which patient education materials can be adjusted to support cancer survivors in advocating for their needs according to their unique situations and preferences.

  4. The state of advocacy in cancer.

    Science.gov (United States)

    Maxwell, G Larry

    2015-12-01

    Non-profit advocacy organizations have been important in raising public awareness, promoting education, and enhancing political activism for issues related to cancer. Grassroots efforts aimed at fund-raising have substantially augmented federal funding for community outreach and research. The objective of this review was to evaluate successful accomplishments of several major non-profit organizations that are focused on cancer. A review of news media, medical literature, and financial records (using GuideStar) was performed to access the organizational structure and productivity of several successful cancer advocacy organizations. Compared to other cancer advocacy groups, the American Cancer Society is the oldest (>100years old) and worth the most with net assets of over $1.25 billion dollars and an annual total revenue of over $900 million dollars. The ACS also has the highest overhead at 41%. Most of the gynecologic cancer advocacy groups are approximately 20years old and have collective total annual revenue of over $17M dollars. The Ovarian Cancer Research Fund has been the most successful at raising funds and building net assets to date while maintaining an overhead of <10%. The most active and financially successful cancer organizations tend to be older, have higher overhead, spend less on total administration, spend more on fund-raising, have more events (rather than a limited number), and use aggressive social media strategies.

  5. Cancer Advocacy in Africa: case studies of innovative practices

    OpenAIRE

    Odedina, Folakemi T; Rodrigues, Belmira

    2013-01-01

    In this paper, we present six case studies describing innovative cancer advocacy programs in Africa. For each case study, an example of an advocacy activity, list of factors contributing to the success of the organization, and an example of an obstacle addressed by the organization are described.

  6. Breast cancer advocacy: changing perceptions Abogacía y cáncer de mama: el cambio en las percepciones

    Directory of Open Access Journals (Sweden)

    Ksenia P Koon

    2009-01-01

    Full Text Available Breast cancer is a significant health burden worldwide. In the United States, the Breast Cancer Advocacy Movement has increased awareness, enhanced dialogue, and provided significant funding opportunities that previously did not exist. Various advocacy programs are beginning to emerge in developing countries in response to the increasing impact breast cancer is having in these regions of the world. This paper discusses the influence of the Breast Cancer Advocacy Movement in the US and proposes a format for working in conjunction with medical experts, political leaders and patient advocates to stimulate discussion and encourage sustainable outcomes in breast cancer internationally.El cáncer de mama es una carga significativa de salud en el mundo. En Estados Unidos, el Movimiento de Abogacía para el Control del Cáncer de Mama ha hecho conciencia, mejorado el diálogo y provisto de oportunidades de financiamiento antes inexistentes. En los países en desarrollo, están emergiendo programas para el combate del cáncer de mama en respuesta al impacto creciente de la enfermedad en estas regiones. Este artículo aborda la influencia del movimiento en Estados Unidos y propone un formato para trabajar en conjunto con expertos en medicina, líderes políticos y defensores de pacientes y estimular la discusión y promoción de resultados sostenibles internacionalmente en cuanto al cáncer de mama.

  7. Climate Change: On Scientists and Advocacy

    Science.gov (United States)

    Schmidt, Gavin A.

    2014-01-01

    Last year, I asked a crowd of a few hundred geoscientists from around the world what positions related to climate science and policy they would be comfortable publicly advocating. I presented a list of recommendations that included increased research funding, greater resources for education, and specific emission reduction technologies. In almost every case, a majority of the audience felt comfortable arguing for them. The only clear exceptions were related to geo-engineering research and nuclear power. I had queried the researchers because the relationship between science and advocacy is marked by many assumptions and little clarity. This despite the fact that the basic question of how scientists can be responsible advocates on issues related to their expertise has been discussed for decades most notably in the case of climate change by the late Stephen Schneider.

  8. Prison health advocacy and its changing boundaries.

    Science.gov (United States)

    Awofeso, Niyi

    2008-01-01

    Advocacy is an important tool for translating population health objectives and research findings into policy and practice, as well as for enhancing stakeholder support for programmes and activities with a potential to improve the health of populations. At the inception of modern prisons, health advocacy approaches focused on appealing to humanitarian and religious sentiments of stakeholders to improve the well-being of prisoners. This approach achieved limited results, not least because of persistent apathy of custodial authorities and the public to prisoners' wellbeing. From the mid twentieth century onwards, a constitutional and human rights approach evolved, with courts becoming actively involved in mandating minimum health standards in prisons. Penal populism eroded public support for a judicial recourse to improving prison health services, and encouraged governments to institute procedural barriers to prisoner-initiated litigation. The author proposes an approach premised on public health principles as an appropriate platform to advocate for improvements in prison health services in this era. Such an advocacy platform combines the altruistic goals of the humanitarian and constitutional rights approaches with an appeal to community's self-interest by alerting the public to the social, financial and health implications inherent in released prisoners suffering from major communicable and chronic diseases re-entering the community. PMID:19061060

  9. Prison health advocacy and its changing boundaries.

    Science.gov (United States)

    Awofeso, Niyi

    2008-01-01

    Advocacy is an important tool for translating population health objectives and research findings into policy and practice, as well as for enhancing stakeholder support for programmes and activities with a potential to improve the health of populations. At the inception of modern prisons, health advocacy approaches focused on appealing to humanitarian and religious sentiments of stakeholders to improve the well-being of prisoners. This approach achieved limited results, not least because of persistent apathy of custodial authorities and the public to prisoners' wellbeing. From the mid twentieth century onwards, a constitutional and human rights approach evolved, with courts becoming actively involved in mandating minimum health standards in prisons. Penal populism eroded public support for a judicial recourse to improving prison health services, and encouraged governments to institute procedural barriers to prisoner-initiated litigation. The author proposes an approach premised on public health principles as an appropriate platform to advocate for improvements in prison health services in this era. Such an advocacy platform combines the altruistic goals of the humanitarian and constitutional rights approaches with an appeal to community's self-interest by alerting the public to the social, financial and health implications inherent in released prisoners suffering from major communicable and chronic diseases re-entering the community.

  10. The future of the cancer prevention workforce: why health literacy, advocacy, and stakeholder collaborations matter.

    Science.gov (United States)

    Sulik, Gayle A; Cameron, Carrie; Chamberlain, Robert M

    2012-05-01

    In considering the role of the cancer prevention workforce in meeting the nation's future health care needs, it is vital to address the considerable gaps in information, communication, training, professional development, roles, and levels of collaboration among diverse disciplines, stakeholders, and constituencies. As part of an October 2009 symposium at The University of Texas MD Anderson Cancer Center entitled "Future Directions in Cancer Prevention and Control: Workforce Implications for Training, Practice, and Policy," the Health Policy and Advocacy Working Group was convened to discuss barriers to closing these gaps. Three major themes emerged from the group's deliberations and are discussed here: (1) the role of critical health literacy and evidence-based collaborations in cancer prevention education, research, and practice; (2) the implications of health advocacy for policy development and clinical and public health practice; and (3) culturally and linguistically appropriate cancer prevention programs and information within advocacy/workforce collaborations. Mechanisms for addressing these gaps are presented. PMID:22311694

  11. Gender, power, and feminisms in breast cancer advocacy: Lessons from the United States and Poland

    OpenAIRE

    Sulik, Gayle; Zierkiewicz, Edyta

    2014-01-01

    The United States breast cancer movement helped to transform breast cancer’s social and medical landscape domestically and, in some ways, internationally. However, differences in gender identities, power relations, and the role of feminism(s) cross‐culturally also shaped breast cancer advocacy itself. After giving a brief introduction to the socio‐historical context of the U.S. and Polish breast cancer movements, this article illuminates some of the linkages and divergences bet...

  12. Effective social justice advocacy: a theory-of-change framework for assessing progress.

    Science.gov (United States)

    Klugman, Barbara

    2011-11-01

    This article offers a theory-of-change framework for social justice advocacy. It describes broad outcome categories against which activists, donors and evaluators can assess progress (or lack thereof) in an ongoing manner: changes in organisational capacity, base of support, alliances, data and analysis from a social justice perspective, problem definition and potential policy options, visibility, public norms, and population level impacts. Using these for evaluation enables activists and donors to learn from and rethink their strategies as the political context and/or actors change over time. The paper presents a case study comparing factors that facilitated reproductive rights policy wins during the transition from apartheid to democracy in South Africa and factors that undermined their implementation in the post-apartheid period. It argues that after legal and policy victories had been won, failure to maintain strong organizations and continually rethink strategies contributed to the loss of government focus on and resources for implementation of new policies. By implication, evaluating effectiveness only by an actual policy change does not allow for ongoing learning to ensure appropriate strategies. It also fails to recognise that a policy win can be overturned and needs vigilant monitoring and advocacy for implementation. This means that funding and organising advocacy should seldom be undertaken as a short-term proposition. It also suggests that the building and maintenance of organisational and leadership capacity is as important as any other of the outcome categories in enabling success.

  13. Big Data Sensors of Organic Advocacy: The Case of Leonardo DiCaprio and Climate Change.

    Science.gov (United States)

    Leas, Eric C; Althouse, Benjamin M; Dredze, Mark; Obradovich, Nick; Fowler, James H; Noar, Seth M; Allem, Jon-Patrick; Ayers, John W

    2016-01-01

    The strategies that experts have used to share information about social causes have historically been top-down, meaning the most influential messages are believed to come from planned events and campaigns. However, more people are independently engaging with social causes today than ever before, in part because online platforms allow them to instantaneously seek, create, and share information. In some cases this "organic advocacy" may rival or even eclipse top-down strategies. Big data analytics make it possible to rapidly detect public engagement with social causes by analyzing the same platforms from which organic advocacy spreads. To demonstrate this claim we evaluated how Leonardo DiCaprio's 2016 Oscar acceptance speech citing climate change motivated global English language news (Bloomberg Terminal news archives), social media (Twitter postings) and information seeking (Google searches) about climate change. Despite an insignificant increase in traditional news coverage (54%; 95%CI: -144 to 247), tweets including the terms "climate change" or "global warming" reached record highs, increasing 636% (95%CI: 573-699) with more than 250,000 tweets the day DiCaprio spoke. In practical terms the "DiCaprio effect" surpassed the daily average effect of the 2015 Conference of the Parties (COP) and the Earth Day effect by a factor of 3.2 and 5.3, respectively. At the same time, Google searches for "climate change" or "global warming" increased 261% (95%CI, 186-335) and 210% (95%CI 149-272) the day DiCaprio spoke and remained higher for 4 more days, representing 104,190 and 216,490 searches. This increase was 3.8 and 4.3 times larger than the increases observed during COP's daily average or on Earth Day. Searches were closely linked to content from Dicaprio's speech (e.g., "hottest year"), as unmentioned content did not have search increases (e.g., "electric car"). Because these data are freely available in real time our analytical strategy provides substantial lead time

  14. Big Data Sensors of Organic Advocacy: The Case of Leonardo DiCaprio and Climate Change.

    Science.gov (United States)

    Leas, Eric C; Althouse, Benjamin M; Dredze, Mark; Obradovich, Nick; Fowler, James H; Noar, Seth M; Allem, Jon-Patrick; Ayers, John W

    2016-01-01

    The strategies that experts have used to share information about social causes have historically been top-down, meaning the most influential messages are believed to come from planned events and campaigns. However, more people are independently engaging with social causes today than ever before, in part because online platforms allow them to instantaneously seek, create, and share information. In some cases this "organic advocacy" may rival or even eclipse top-down strategies. Big data analytics make it possible to rapidly detect public engagement with social causes by analyzing the same platforms from which organic advocacy spreads. To demonstrate this claim we evaluated how Leonardo DiCaprio's 2016 Oscar acceptance speech citing climate change motivated global English language news (Bloomberg Terminal news archives), social media (Twitter postings) and information seeking (Google searches) about climate change. Despite an insignificant increase in traditional news coverage (54%; 95%CI: -144 to 247), tweets including the terms "climate change" or "global warming" reached record highs, increasing 636% (95%CI: 573-699) with more than 250,000 tweets the day DiCaprio spoke. In practical terms the "DiCaprio effect" surpassed the daily average effect of the 2015 Conference of the Parties (COP) and the Earth Day effect by a factor of 3.2 and 5.3, respectively. At the same time, Google searches for "climate change" or "global warming" increased 261% (95%CI, 186-335) and 210% (95%CI 149-272) the day DiCaprio spoke and remained higher for 4 more days, representing 104,190 and 216,490 searches. This increase was 3.8 and 4.3 times larger than the increases observed during COP's daily average or on Earth Day. Searches were closely linked to content from Dicaprio's speech (e.g., "hottest year"), as unmentioned content did not have search increases (e.g., "electric car"). Because these data are freely available in real time our analytical strategy provides substantial lead time

  15. Circus monkeys or change agents? Civil society advocacy for HIV/AIDS in adverse policy environments.

    Science.gov (United States)

    Spicer, Neil; Harmer, Andrew; Aleshkina, Julia; Bogdan, Daryna; Chkhatarashvili, Ketevan; Murzalieva, Gulgun; Rukhadze, Natia; Samiev, Arnol; Walt, Gill

    2011-12-01

    This paper explores the factors enabling and undermining civil society efforts to advocate for policy reforms relating to HIV/AIDS and illicit drugs in three countries in Eastern Europe and Central Asia: Georgia, Kyrgyzstan and Ukraine. It examines how political contexts and civil society actors' strengths and weaknesses inhibit or enable advocacy for policy change - issues that are not well understood in relation to specific policy areas such as HIV/AIDS, or particular regions of the world where national policies are believed to be major drivers of the HIV/AIDS epidemic. The study is based on in-depth interviews with representatives of civil society organizations (CSOs) (n = 49) and national level informants including government and development partners (n = 22). Our policy analysis identified a culture of fear derived from concerns for personal safety but also risk of losing donor largesse. Relations between CSOs and government were often acrimonious rather than synergistic, and while we found some evidence of CSO collective action, competition for external funding - in particular for HIV/AIDS grants from the Global Fund to Fight AIDS, Tuberculosis and Malaria was often divisive. Development partners and government tend to construct CSOs as service providers rather than advocates. While some advocacy was tolerated by governments, CSO participation in the policy process was, ultimately, perceived to be tokenistic. This was because there are financial interests in maintaining prohibitionist legislation: efforts to change punitive laws directed at the behaviors of minority groups such as injecting drug users have had limited impact.

  16. Big Data Sensors of Organic Advocacy: The Case of Leonardo DiCaprio and Climate Change

    Science.gov (United States)

    Althouse, Benjamin M.; Dredze, Mark; Obradovich, Nick; Fowler, James H.; Noar, Seth M.; Allem, Jon-Patrick

    2016-01-01

    The strategies that experts have used to share information about social causes have historically been top-down, meaning the most influential messages are believed to come from planned events and campaigns. However, more people are independently engaging with social causes today than ever before, in part because online platforms allow them to instantaneously seek, create, and share information. In some cases this “organic advocacy” may rival or even eclipse top-down strategies. Big data analytics make it possible to rapidly detect public engagement with social causes by analyzing the same platforms from which organic advocacy spreads. To demonstrate this claim we evaluated how Leonardo DiCaprio’s 2016 Oscar acceptance speech citing climate change motivated global English language news (Bloomberg Terminal news archives), social media (Twitter postings) and information seeking (Google searches) about climate change. Despite an insignificant increase in traditional news coverage (54%; 95%CI: -144 to 247), tweets including the terms “climate change” or “global warming” reached record highs, increasing 636% (95%CI: 573–699) with more than 250,000 tweets the day DiCaprio spoke. In practical terms the “DiCaprio effect” surpassed the daily average effect of the 2015 Conference of the Parties (COP) and the Earth Day effect by a factor of 3.2 and 5.3, respectively. At the same time, Google searches for “climate change” or “global warming” increased 261% (95%CI, 186–335) and 210% (95%CI 149–272) the day DiCaprio spoke and remained higher for 4 more days, representing 104,190 and 216,490 searches. This increase was 3.8 and 4.3 times larger than the increases observed during COP’s daily average or on Earth Day. Searches were closely linked to content from Dicaprio’s speech (e.g., “hottest year”), as unmentioned content did not have search increases (e.g., “electric car”). Because these data are freely available in real time our

  17. Southern voices on climate policy choices: Analysis of and lessons learned from civil society advocacy on climate change

    Energy Technology Data Exchange (ETDEWEB)

    Reid, Hannah; Ampomah, Gifty; Prera, Maria Isabel Olazabal; Rabbani, Golam; Zvigadza, Shepard

    2012-05-15

    This report provides an analysis of the tools and tactics advocacy groups use to influence policy responses to climate change at international, regional, national and sub-national levels. More than 20 climate networks and their member organisations have contributed to the report with their experiences of advocacy on climate change, including over 70 case studies from a wide range of countries - including many of the poorest - in Africa, Asia, Latin America and the Pacific. These advocacy activities primarily target national governments, but also international and regional processes, donors and the private sector. Analyses and case studies show how civil society plays key roles in pushing for new laws, programmes, policies or strategies on climate change, in holding governments to account on their commitments; in identifying the lack of joined-up government responses to climate change; and in ensuring that national policy making does not forget the poor and vulnerable. The report is the first joint product of the Southern Voices Capacity Building Programme, or for short: Southern Voices on Climate Change.

  18. Inadvertent advocacy.

    Science.gov (United States)

    Wilhere, George F

    2012-02-01

    Policy advocacy is an issue regularly debated among conservation scientists. These debates have focused on intentional policy advocacy by scientists, but advocacy can also be unintentional. I define inadvertent policy advocacy as the act of unintentionally expressing personal policy preferences or ethical judgments in a way that is nearly indistinguishable from scientific judgments. A scientist may be well intentioned and intellectually honest but still inadvertently engage in policy advocacy. There are two ways to inadvertently engage in policy advocacy. First, a scientist expresses an opinion that she or he believes is a scientific judgment but it is actually an ethical judgment or personal policy preference. Second, a scientist expresses an opinion that he or she knows is an ethical judgment or personal policy preference but inadvertently fails to effectively communicate the nature of the opinion to policy makers or the public. I illustrate inadvertent advocacy with three examples: recovery criteria in recovery plans for species listed under the U.S. Endangered Species Act, a scientific peer review of a recovery plan for the Northern Spotted Owl (Strix occidentalis caurina), and the International Union for Conservation of Nature's definition of threatened. In each example, scientists expressed ethical judgments or policy preferences, but their value judgments were not identified as such, and, hence, their value judgments were opaque to policy makers and the public. Circumstances suggest their advocacy was inadvertent. I believe conservation scientists must become acutely aware of the line between science and policy and avoid inadvertent policy advocacy because it is professional negligence, erodes trust in scientists and science, and perpetuates an ethical vacuum that undermines the rational political discourse necessary for the evolution of society's values. The principal remedy for inadvertent advocacy is education of conservation scientists in an effort to

  19. Biochemical Changes in Cancer

    Directory of Open Access Journals (Sweden)

    Husamettin Erdamar

    2014-06-01

    Full Text Available After cardiovascular diseases, the most common reasons of death in the world is cancer. However, oncologists think that %u201CNobody dies from cancer, the patiences pass away due to the results of metabolic changes stemmed from cancer%u201D. The identification of metabolic changes which is caused by cancer opens new insights to doctors in diagnosing and therapy. For instance, the method of imaging of Positron emission tomography (PET, which is used for the cancer grading, involves the changes of glucose metabolism in cancer cells. Another case related to this subject is that the differential diagnosis between residue metastasis and edema of the suspect area in the image of postoperative control brain magnetic resonance (MR for a patient who is operated because of brain tumor can be made via MR spectroscope device by analyizing the metabolic activity of that area regarding the level of choline, creatinine, N-Asetyl aspartene and lactate. In this review, the main changes of metabolism of protein, carbonhydrate and lipid, and membrane structure in cancer patience will be mentioned. Furthermore, paraneoplastic syndrome and the tumor lysis syndrome, an urgent oncologic case, which can be seen in the 20 percent of cancer patience, will be undertaken.

  20. Historical note: How bringing women's health advocacy groups to WHO helped change the research agenda.

    Science.gov (United States)

    Cottingham, Jane

    2015-05-01

    The politics of population control and its sometimes coercive methods in developing countries documented during the 1960s, 70s and 80s, gave rise to strong opposition by women's groups, and put into question the safety of contraceptive methods that were being developed and introduced into countries. In 1991, the Special Programme on Human Reproduction at the World Health Organization, a research programme focused on development of new methods and safety assessments of existing fertility regulation methods, started a process of "dialogue" meetings between scientists and women's health advocacy groups which lasted for nearly a decade. This paper describes the process of these meetings and what they achieved in terms of bringing new or different research topics into the agenda, and some of the actions taken as a result. PMID:26278829

  1. Scaling up cervical cancer screening in the midst of human papillomavirus vaccination advocacy in Thailand

    Directory of Open Access Journals (Sweden)

    Teerawattananon Yot

    2010-07-01

    Full Text Available Abstract Background Screening tests for cervical cancer are effective in reducing the disease burden. In Thailand, a Pap smear program has been implemented throughout the country for 40 years. In 2008 the Ministry of Public Health (MoPH unexpectedly decided to scale up the coverage of free cervical cancer screening services, to meet an ambitious target. This study analyzes the processes and factors that drove this policy innovation in the area of cervical cancer control in Thailand. Methods In-depth interviews with key policy actors and review of relevant documents were conducted in 2009. Data analysis was guided by a framework, developed on public policy models and existing literature on scaling-up health care interventions. Results Between 2006 and 2008 international organizations and the vaccine industry advocated the introduction of Human Papillomavirus (HPV vaccine for the primary prevention of cervical cancer. Meanwhile, a local study suggested that the vaccine was considerably less cost-effective than cervical cancer screening in the Thai context. Then, from August to December 2008, the MoPH carried out a campaign to expand the coverage of its cervical cancer screening program, targeting one million women. The study reveals that several factors were influential in focusing the attention of policymakers on strengthening the screening services. These included the high burden of cervical cancer in Thailand, the launch of the HPV vaccine onto the global and domestic markets, the country’s political instability, and the dissemination of scientific evidence regarding the appropriateness of different options for cervical cancer prevention. Influenced by the country’s political crisis, the MoPH’s campaign was devised in a very short time. In the view of the responsible health officials, the campaign was not successful and indeed, did not achieve its ambitious target. Conclusion The Thai case study suggests that the political crisis was a

  2. Cancer-associated lysosomal changes

    DEFF Research Database (Denmark)

    Kallunki, T; Olsen, O D; Jaattela, Marja

    2013-01-01

    Rapidly dividing and invasive cancer cells are strongly dependent on effective lysosomal function. Accordingly, transformation and cancer progression are characterized by dramatic changes in lysosomal volume, composition and cellular distribution. Depending on one's point of view, the cancer......-targeting anti-cancer drugs. In this review we compile our current knowledge on cancer-associated changes in lysosomal composition and discuss the consequences of these alterations to cancer progression and the possibilities they can bring to cancer therapy.Oncogene advance online publication, 9 July 2012; doi...

  3. Patient Advocacy in an Obstetric Setting.

    Science.gov (United States)

    Heelan-Fancher, Lisa M

    2016-10-01

    A correlation study design was used to examine the interrelatedness of power, attitudes regarding intermittent fetal monitoring, and perceived barriers to research utilization with a labor and delivery nurse's attitude toward patient advocacy using the conceptual framework of the science of unitary human beings. The linear combination of the three independent variables was significantly correlated to attitude toward patient advocacy and power as knowing participation in change had the greatest impact on patient advocacy. PMID:27641281

  4. Patient Advocacy in an Obstetric Setting.

    Science.gov (United States)

    Heelan-Fancher, Lisa M

    2016-10-01

    A correlation study design was used to examine the interrelatedness of power, attitudes regarding intermittent fetal monitoring, and perceived barriers to research utilization with a labor and delivery nurse's attitude toward patient advocacy using the conceptual framework of the science of unitary human beings. The linear combination of the three independent variables was significantly correlated to attitude toward patient advocacy and power as knowing participation in change had the greatest impact on patient advocacy.

  5. Carrying out a Language Policy Change: Advocacy Coalitions and the Management of Linguistic Landscape

    Science.gov (United States)

    Sloboda, Marian; Szabo-Gilinger, Eszter; Vigers, Dick; Simicic, Lucija

    2010-01-01

    This paper focuses on agency in language policy change. The object of the analysis is the processes of bilingualization of signage in three European towns. Located in the Czech Republic, Hungary and Wales, the towns differ in various respects, including the extent to which signage language policies have faced opposition and threatened social…

  6. Dietary changes among cancer survivors.

    Science.gov (United States)

    Maskarinec, G; Murphy, S; Shumay, D M; Kakai, H

    2001-03-01

    Given the limited scientific knowledge about dietary factors that affect cancer recurrence, dietary guidelines for cancer survivors are similar to general recommendations on healthy eating. This study explored the patterns of and motivation for, dietary changes among cancer patients. We conducted in-person interviews with 143 cancer survivors who were chosen from a mail survey on complementary and alternative medicine among cancer patients. We applied qualitative analysis using the software package NUD*IST to sort and code the transcribed interviews. The majority of dietary changes reported by 69 cancer patients agreed with current nutritional recommendations, such as decreasing meat and fat intake and increasing the consumption of vegetables and fruits. However, many diet changers also reported the intake of herbal and vitamin supplements, many with unproven effects. The major themes for changing diet were hopes that nutrition would increase well-being, maintain health and prevent cancer recurrence and beliefs that foods that cause or prevent cancer should be avoided and increased, respectively. Many cancer patients use non-scientific reasons when deciding on dietary changes and supplement use. Increasing communication with health care providers may prevent the use of extreme diets, unproven and possibly harmful supplements and reduce exaggerated hopes related to the benefits of a particular dietary regimen. PMID:11827263

  7. Epigenetic changes in colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    Yan Jia; Mingzhou Guo

    2013-01-01

    Epigenetic changes frequently occur in human colorectal cancer.Genomic global hypomethylation,gene promoter region hypermethylation,histone modifications,and alteration of miRNA patterns are major epigenetic changes in colorectal cancer.Loss of imprinting (LOI) is associated with colorectal neoplasia.Folate deficiency may cause colorectal carcinogenesis by inducing gene-specific hypermethylation and genomic global hypomethylation.HDAC inhibitors and demethylating agents have been approved by the FDA for myelodysplastic syndrome and leukemia treatment.Non-coding RNA is regarded as another kind of epigenetic marker in colorectal cancer.This review is mainly focused on DNA methylation,histone modification,and microRNA changes in colorectal cancer.

  8. Recognizing new opportunities: reconceptualizing policy advocacy in everyday organizational practice.

    Science.gov (United States)

    Mosley, Jennifer

    2013-07-01

    Policy advocacy is a concept that is of both practical and historical importance to the profession of social work. To keep up with developments in how advocacy is practiced at the ground level, however, social work research on advocacy needs to expand in scope. Changes in government contracting and public management practices have reshaped the opportunity structure for policy advocacy, incentivizing a kind of advocacy that is routine, professionalized, and collaborative. At the same time, these practices have raised questions about democratic representation and the degree to which social work advocacy adequately reflects client concerns. This article presents a model for how policy advocacy can be usefully reconceptualized to account for changes in the policy and funding environment and concludes by suggesting ways that social work research and theory can better reflect practice realities. PMID:24032304

  9. Advocacy evaluation: challenges and emerging trends.

    Science.gov (United States)

    Devlin-Foltz, David; Fagen, Michael C; Reed, Ehren; Medina, Robert; Neiger, Brad L

    2012-09-01

    Devising, promoting, and implementing changes in policies and regulations are important components of population-level health promotion. Whether advocating for changes in school meal nutrition standards or restrictions on secondhand smoke, policy change can create environments conducive to healthier choices. Such policy changes often result from complex advocacy efforts that do not lend themselves to traditional evaluation approaches. In a challenging fiscal environment, allocating scarce resources to policy advocacy may be particularly difficult. A well-designed evaluation that moves beyond inventorying advocacy activities can help make the case for funding advocacy and policy change efforts. Although it is one thing to catalog meetings held, position papers drafted, and pamphlets distributed, it is quite another to demonstrate that these outputs resulted in useful policy change outcomes. This is where the emerging field of advocacy evaluation fits in by assessing (among other things) strategic learning, capacity building, and community organizing. Based on recent developments, this article highlights several challenges advocacy evaluators are currently facing and provides new resources for addressing them. PMID:22773623

  10. Lipids changes in liver cancer

    Institute of Scientific and Technical Information of China (English)

    JIANG Jing-ting; XU Ning; ZHANG Xiao-ying; WU Chang-ping

    2007-01-01

    Liver is one of the most important organs in energy metabolism.Most plasma apolipoproteins and endogenous lipids and lipoproteins are synthesized in the liver.It depends on the integrity of liver cellular function,which ensures homeostasis of lipid and lipoprotein metabolism.When liver cancer occurs,these processes are impaired and the plasma lipid and lipoprotein patterns may be changed.Liver cancer is the fifth common malignant tumor worldwide,and is closely related to the infections of hepatitis B virus (HBV) and hepatitis C virus (HCV).HBV and HCV infections are quite common in China and other Southeast Asian countries.In addition,liver cancer is often followed by a procession of chronic hepatitis or cirrhosis,so that hepatic function is damaged obviously on these bases,which may significantly influence lipid and lipoprotein metabolism in vivo.In this review we summarize the clinical significance of lipid and lipoprotein metabolism under liver cancer.

  11. A History of Music Education Advocacy.

    Science.gov (United States)

    Mark, Michael L.

    2002-01-01

    Provides a history of advocacy in music education discussing when formal advocacy started as well as advocacy with government agencies, the state level, and other types of advocacy. Includes a bibliography of resources related to music advocacy. (CMK)

  12. Philosophy + Advocacy = Success

    Science.gov (United States)

    Tutt, Kevin; Townley, Marc

    2011-01-01

    Knowledge about music advocacy strategies has long been promoted as important for music educators, not only for the benefit of their individual programs but also for the specific benefit of music students and the general public. This article suggests an approach to advocacy grounded in the teacher's professional beliefs, phrased in terms…

  13. Climate change and skin cancer.

    Science.gov (United States)

    van der Leun, Jan C; de Gruijl, Frank R

    2002-05-01

    Depletion of the ozone layer and climate change by the increasing greenhouse effect are distinctly different processes. It is becoming quite clear, however, that the two global environmental problems are interlinked in several ways [D. L. Albritton, P. J Aucamp, G. Mégie, R. T. Watson, Scientific Assessment of Ozone Depletion, 1998, World Meteorological Organization, Global Ozone Research and Monitoring Project, Report No. 44 (WMO, Geneva, 1998)]. In the present analysis we deal with the possibility of such an interlinkage within one effect on human health, namely, skin cancer. The increase in the incidence of skin cancer is one of the most extensively studied effects of increasing ultraviolet radiation by ozone depletion (F. R. de Gruijl, Skin cancer and solar radiation, Eur. J Cancer, 1999, 35, 2003-2009). We wondered if this impact could also be influenced by increasing environmental temperatures. Here we show that it is likely that such an influence will occur. For the same reason, it is likely that the baseline incidence of skin cancer will be augmented by rising temperatures, which may become significant in magnitude. PMID:12653470

  14. Self-Advocacy. Feature Issue.

    Science.gov (United States)

    Hayden, Mary F., Ed.; Ward, Nancy, Ed.

    1994-01-01

    This feature issue newsletter looks at issues the self-advocacy movement is raising and the contributions it is making to the lives of people with developmental disabilities. Articles by self-advocates and advisors to self-advocacy organizations talk about their self-advocacy experiences, barriers to self-advocacy, and ways to support it. Primary…

  15. Lifestyle Changes After Laryngeal or Hypopharyngeal Cancer

    Science.gov (United States)

    ... laryngeal or hypopharyngeal cancer affect your emotional health? Lifestyle changes after laryngeal or hypopharyngeal cancer You can’ ... people want to know if there are specific lifestyle changes they can make to reduce their risk ...

  16. The voice of Florence Nightingale on advocacy.

    Science.gov (United States)

    Selanders, Louise C; Crane, Patrick C

    2012-01-01

    Modern nursing is complex, ever changing, and multi focused. Since the time of Florence Nightingale, however, the goal of nursing has remained unchanged, namely to provide a safe and caring environment that promotes patient health and well being. Effective use of an interpersonal tool, such as advocacy, enhances the care-giving environment. Nightingale used advocacy early and often in the development of modern nursing. By reading her many letters and publications that have survived, it is possible to identify her professional goals and techniques. Specifically, Nightingale valued egalitarian human rights and developed leadership principles and practices that provide useful advocacy techniques for nurses practicing in the 21st century. In this article we will review the accomplishments of Florence Nightingale, discuss advocacy in nursing and show how Nightingale used advocacy through promoting both egalitarian human rights and leadership activities. We will conclude by exploring how Nightingale's advocacy is as relevant for the 21st century as it was for the 19th century. PMID:22320877

  17. Technological changes in cancer prevention.

    Science.gov (United States)

    Fishbein, L

    1992-01-01

    Exposures and technologies in the workplace are changing due to a variety of factors, including newly developed technologies, mechanization and automation, and improvements in industrial hygiene primarily effected in many developed countries. In addition substitution and removal of carcinogenic constituents in the workplace and general environment are increasing in a number of instances, particularly in North America, Western Europe, and Japan, and they are being accompanied as well by remediation either by source reduction, recycling, or compliance to more stringent national and international regulations and standards. This overview highlights some of the strategies employed in the technological changes in cancer prevention and cites examples in source reduction, changes in formulation, product or process changes, recycling, and hazardous materials management.

  18. The Dance of Advocacy

    OpenAIRE

    Lothian, Judith A.

    2005-01-01

    A childbirth educator asks how she can continue to use best evidence and prepare women adequately for birth within the constraints of a hospital practice that pressures educators not to “rock the boat.” This column discusses the challenge of advocating for normal birth and the dangers inherent in the advocacy role. Advocacy requires the childbirth educator to “dance” with many partners, including physicians and hospitals. Strategies for inviting colleagues and class participants onto the danc...

  19. Advocacy and technology assessment

    Science.gov (United States)

    Jones, E. M.

    1975-01-01

    A highly structured treatment is presented of adversarial systems as they apply to technology assessment. One approach to the problem of adequate criteria of assessment focuses upon the internal operations of assessment entities; operations include problem perception, problem formulation, selection, utilization, determination, and evaluation. Potential contributions of advocacy as a mode of inquiry in technology are discussed; advocacy is evaluated by representative sets of criteria of adequate assessment which include participant criteria, perspectives criteria, situations criteria, base values criteria, and strategies criteria.

  20. Advocacy to address disabling diseases: TDR holds brainstorming session.

    Science.gov (United States)

    1998-06-01

    The UN Development Program/World Bank/World Health Organization's Special Program for Research and Training in Tropical Diseases hosted a meeting in January 1998 to discuss new ways of generating sustained commitment to combat disabling tropical diseases, such as filariasis and onchocerciasis. The participants agreed that advocacy should be targeted to a wider audience than the health sector, including international donors, industry, national governments, and endemic communities themselves. Advocacy efforts will be supported by development of a standard protocol that will 1) identify and present the type of evidence that generates sustainable commitment, 2) develop and use appropriate messages for each audience, 3) evaluate new advocacy approaches for their impact on behavioral change and disease control, and 4) evaluate advocacy campaigns. Advocacy about lymphatic filariasis will target all levels, while advocacy about onchocerciasis will target national and local levels.

  1. Lifestyle changes for prevention of breast cancer

    OpenAIRE

    Hashemi, Seyed Hesam Bani; Karimi, Samieh; Mahboobi, Hamidreza

    2014-01-01

    Breast cancer is the second most common cause of death from cancer among women. Lifestyle changes are shown to be important in the prevention of breast cancer. Diet, physical activity, smoking, alcohol use, and vitamin and mineral use are key factors influencing the risk of breast cancer among women. Because these factors are related to each other, it is difficult to assess their individual roles in breast cancer. Some of these factors are alterable, meaning that women can decrease their risk...

  2. Changing paradigm in treatment of lung cancer

    Institute of Scientific and Technical Information of China (English)

    Sundaram Viswanath; Abhishek Pathak; Amul Kapoor; Anvesh Rathore; Bhupendra Nath Kapur

    2016-01-01

    Lung cancer is one of the most common and deadliest forms of cancer. It accounts for 13% of all new cancer cases and 19% of cancer-related deaths. In India, lung cancer constitutes 6.9% of all new cancer cases and 9.3% of all cancer cases. There has also been a dramatic rise worldwide in both the absolute and relative frequencies of lung cancer occurrence. In 1953 it became the most common cause of cancer mortality in men. By 1985, it became the leading cause of cancer deaths in women, causing almost twice as many deaths as breast cancer. The demographic proifle of lung cancer has changed greatly over the years; however, methods for diagnosing, screening, and managing lung cancer patients have improved. This is due to our growing understanding of the biology of lung cancer. It is now possible to further deifne lung cancer types beyond small cell lung carcinoma and non-small cell lung carcinoma. Moreover, new histology-based therapeutic modalities have been developed, and more new lung cancer biomarkers have been uncovered. Therefore, more detailed histological characterization of lung cancer samples is warranted in order to determine the best course of treatment for speciifc patients. This review article describes how these new molecular technologies are shaping the way lung cancer can be treated in future.

  3. Social Justice Advocacy: Community Collaboration and Systems Advocacy

    Science.gov (United States)

    Lopez-Baez, Sandra I.; Paylo, Matthew J.

    2009-01-01

    This article discusses the community collaboration and systems advocacy domains of the ACA (American Counseling Association) Advocacy Competencies (J. A. Lewis, M. S. Arnold, R. House, & R. L. Toporek, 2002). A case illustration is presented, and the 8 Advocacy Competencies within each domain are applied to the case study.

  4. Advocacy and Accessibility Standards in the New "Code of Professional Ethics for Rehabilitation Counselors"

    Science.gov (United States)

    Waldmann, Ashley K.; Blackwell, Terry L.

    2010-01-01

    This article addresses the changes in the Commission on Rehabilitation Counselor Certification's 2010 "Code of Professional Ethics for Rehabilitation Counselors" as they relate to Section C: Advocacy and Accessibility. Ethical issues are identified and discussed in relation to advocacy skills and to advocacy with, and on behalf of, the client; to…

  5. Public health and media advocacy.

    Science.gov (United States)

    Dorfman, Lori; Krasnow, Ingrid Daffner

    2014-01-01

    Media advocacy blends communications, science, politics, and advocacy to advance public health goals. In this article, we explain how media advocacy supports the social justice grounding of public health while addressing public health's "wicked problems" in the context of American politics. We outline media advocacy's theoretical foundations in agenda setting and framing and describe its practical application, from the layers of strategy to storytelling, which can illuminate public health solutions for journalists, policy makers, and the general public. Finally, we describe the challenges in evaluating media advocacy campaigns.

  6. Advocacy for eye care

    Directory of Open Access Journals (Sweden)

    Thulasiraj D Ravilla

    2012-01-01

    Full Text Available The effectiveness of eye care service delivery is often dependant on how the different stakeholders are aligned. These stakeholders range from the ministries of health who have the capacity to grant government subsidies for eye care, down to the primary healthcare workers who can be enrolled to screen for basic eye diseases. Advocacy is a tool that can help service providers draw the attention of key stakeholders to a particular area of concern. By enlisting the support, endorsement and participation of a wider circle of players, advocacy can help to improve the penetration and effectiveness of the services provided. There are several factors in the external environmental that influence the eye care services - such as the availability of trained manpower, supply of eye care consumables, government rules and regulations. There are several instances where successful advocacy has helped to create an enabling environment for eye care service delivery. Providing eye care services in developing countries requires the support - either for direct patient care or for support services such as producing trained manpower or for research and dissemination. Such support, in the form of financial or other resources, can be garnered through advocacy.

  7. Epoetin and Darbepoetin Treatment for Adults with Cancer

    Science.gov (United States)

    ... Health Disparities and Cancer For Patient Advocates Public Policy Advocacy Cancer Awareness Dates Survivorship Blog About Us You ... Health Disparities and Cancer For Patient Advocates Public Policy Advocacy Cancer Awareness Dates Cancer.Net provides timely, comprehensive, ...

  8. Recovering and Framing the George I. Sanchez Legacy of Chicana/o Student and Policy Advocacy: Utilizing Data for Social Change

    Science.gov (United States)

    Rodríguez, Cristóbal

    2014-01-01

    Recovering and critically examining the pioneering scholarship and history of George I. Sanchez provides an interpretation toward a legacy of a Chicana/o student and policy advocacy framework for Chicana/o scholars to consider. The author of this work applies a critical policy theoretical analysis by Frank Fischer to develop a Chicana/o student…

  9. Building a Latin American cancer patient advocacy movement: Latin American cancer NGO regional overview Desarrollando un movimiento de apoyo para pacientes de cáncer en America Latina: resumen regional - ONGs de cáncer

    Directory of Open Access Journals (Sweden)

    Alessandra Durstine

    2009-01-01

    Full Text Available The objective of the this paper is to assess and identify the key strengths and weaknesses for cancer control NGOs in Latin America, with the goal to make recommendations about how to improve thev impact of the patient advocacy movement as it pertains to cancer. The methods included literature review, expert interviews and site visits to Latin American cancer hospitals and NGOs. The overall findings conclude that NGOs currently do not take a leadership role in cancer control in Latin America. The lack of a survivorship movement, faulty patient information services and failure of the governments to include NGOs in policy creation are identified as areas for further project work and collaboration. The stigma of cancer still remains and a burgeoning patient movement can be created to help destigmatize and debunk the myths that surround cancer.El objetivo de este artículo es el de identificar y evaluar las fortalezas y debilidades clave de las ONG dedicadas al control del cáncer en Latinoamérica, con el fin de generar recomendaciones sobre el modo de mejorar el impacto del movimiento de apoyo para pacientes de cáncer. Los métodos incluyeron una revisión de la literatura, entrevistas a expertos y visitas a hospiptales y ONG dedicados al cáncer en Latinoamérica. Los hallazgos principales permiten concluir que en este momento las ONG no tienen un rol de liderazgo para el control del cáncer en Latinoamérica. La ausencia de un movimiento de sobrevivientes, servicios de información deficientes a los pacientes y el fracaso del gobierno para incluir a las ONG en la creación de políticas se identifican como áreas de trabajo y colaboración en proyectos a futuro. El estigma del cáncer aún subsiste y es factible crear un movimiento que florezca y ayude a desvanecerlo al exponer los mitos que rodean este padecimiento.

  10. Advocacy and IPR, tutorial 4

    CERN Document Server

    CERN. Geneva

    2005-01-01

    With open access and repositories assuming a high profile some may question whether advocacy is still necessary. Those involved in the business of setting up and populating repositories are aware that in the majority of institutions there is still a great need for advocacy. This tutorial will give participants an opportunity to discuss different advocacy methods and approaches, including the 'top down' and 'bottom up' approach, publicity methods and the opportunities offered by funding body positions on open access. Participants will have the opportunity to share experiences of what works and what doesn't. The advocacy role often encompasses responsibility for advising academics on IPR issues. This is a particularly critical area where repository staff are engaged in depositing content on behalf of academics. The tutorial will offer an opportunity to discuss the IPR issues encountered by those managing repositories. The tutorial will draw on the experience of participants who have been engaged in advocacy act...

  11. Patient advocacy: barriers and facilitators

    Directory of Open Access Journals (Sweden)

    Nikravesh Mansoure

    2006-03-01

    Full Text Available Abstract Background During the two recent decades, advocacy has been a topic of much debate in the nursing profession. Although advocacy has embraced a crucial role for nurses, its extent is often limited in practice. While a variety of studies have been generated all over the world, barriers and facilitators in the patient advocacy have not been completely identified. This article presents the findings of a study exploring the barriers and facilitators influencing the role of advocacy among Iranian nurses. Method This study was conducted by grounded theory method. Participants were 24 Iranian registered nurses working in a large university hospital in Tehran, Iran. Semi-structured interviews were used for data collection. All interviews were transcribed verbatim and simultaneously Constant comparative analysis was used according to the Strauss and Corbin method. Results Through data analysis, several main themes emerged to describe the factors that hindered or facilitated patient advocacy. Nurses in this study identified powerlessness, lack of support, law, code of ethics and motivation, limited communication, physicians leading, risk of advocacy, royalty to peers, and insufficient time to interact with patients and families as barriers to advocacy. As for factors that facilitated nurses to act as a patient advocate, it was found that the nature of nurse-patient relationship, recognizing patients' needs, nurses' responsibility, physician as a colleague, and nurses' knowledge and skills could be influential in adopting the advocacy role. Conclusion Participants believed that in this context taking an advocacy role is difficult for nurses due to the barriers mentioned. Therefore, they make decisions and act as a patient's advocate in any situation concerning patient needs and status of barriers and facilitators. In most cases, they can not act at an optimal level; instead they accept only what they can do, which we called 'limited advocacy' in

  12. Advocacy: exploring the concept.

    Science.gov (United States)

    Mardell, A

    1996-10-01

    The concept of the nurse as the patient's advocate is one that has become popular in the last fifteen years or so in both North America and the United Kingdom, having its basis in nursing theory. The UKCC first embraced the concept, stating in the Code of Professional Conduct that nurses must; 'act always in such a manner so as to promote and safeguard the interests and well being of patients and clients'. This is a laudable principle and one that nurses cannot dispute as there are many members of our society who are weak and vulnerable and may be unable to speak up for themselves. But are nurses always in a position to be an advocate for their patients? As the nature of nursing is so diverse then the nature of advocacy will be different in the multifarious settings in which nurses practise. Can theatre nurses ever be in a position to act as an advocate for a patient who is often anaesthetised? What precisely is advocacy and is the Concise Oxford Dictionary definition of 'one who pleads for another' appropriate in the nursing context? Then there is the position of nurses in the healthcare organisation in which they practise. In advocating for their patients, nurses may find they are pleading a case for a patient, or a group of patients, that could bring the nurse into conflict with their medical colleagues or with the management of the organisation by whom they are employed. Additionally, they may not posses the skills and knowledge to advocate effectively under such circumstances. Nursing is littered with the casualties of such conflicts over the years, the most publicised of whom, in the UK, was probably Graham Pink who lost his job as a charge nurse after drawing public attention to what he considered to be an unacceptable standard of care in the hospital in which he worked. PMID:8974516

  13. Genetic and molecular changes in ovarian cancer

    Science.gov (United States)

    Hollis, Robert L; Gourley, Charlie

    2016-01-01

    Epithelial ovarian cancer represents the most lethal gynecological malignancy in the developed world, and can be divided into five main histological subtypes: high grade serous, endometrioid, clear cell, mucinous and low grade serous. These subtypes represent distinct disease entities, both clinically and at the molecular level. Molecular analysis has revealed significant genetic heterogeneity in ovarian cancer, particularly within the high grade serous subtype. As such, this subtype has been the focus of much research effort to date, revealing molecular subgroups at both the genomic and transcriptomic level that have clinical implications. However, stratification of ovarian cancer patients based on the underlying biology of their disease remains in its infancy. Here, we summarize the molecular changes that characterize the five main ovarian cancer subtypes, highlight potential opportunities for targeted therapeutic intervention and outline priorities for future research.

  14. Assessing the Efficacy of a School Health Education Advocacy Lesson with College Students

    Science.gov (United States)

    Wallen, Michele; Chaney, Beth H.; Birch, David A.

    2012-01-01

    Purpose: The researchers evaluated the efficacy of an advocacy lesson to assess change in intentions to advocate for school health education. This study also measured changes in participants' understanding the importance of school health education and perceived effectiveness in applying advocacy skills. Methods: A convenience sample of college…

  15. Glycan changes: cancer metastasis and anti-cancer vaccines

    Indian Academy of Sciences (India)

    Min Li; Lujun Song; Xinyu Qin

    2010-12-01

    Complex carbohydrates, which are major components of the cell membrane, perform important functions in cell–cell and cell–extracellular matrix interactions, as well as in signal transduction. They comprise three kinds of biomolecules: glycoproteins, proteoglycans and glycosphingolipids. Recent studies have also shown that glycan changes in malignant cells take a variety of forms and mediate key pathophysiological events during the various stages of tumour progression. Glycosylation changes are universal hallmarks of malignant transformation and tumour progression in human cancer, which take place on the whole cells or some specific molecules. Accordingly, those changes make them prominent candidates for cancer biomarkers in the meantime. This review mainly focuses on the correlation between glycosylation and the metastasis potential of tumour cells from comprehensive aspects to further address the vital roles of glycans in oncogenesising. Moreover, utilizing these glycosylation changes to ward off tumour metastasis by means of anti-adhesion approach or devising anti-cancer vaccine is one of promising targets of future study.

  16. Patient advocacy: the role of the nurse.

    Science.gov (United States)

    Choi, Pin Pin

    2015-06-10

    The role of nurses as patient advocates is well recognised by healthcare professionals, yet the processes and practices involved in patient advocacy are not clearly understood. A suboptimal level of advocacy is often apparent in the literature, encompassing paternalistic concepts of protecting patients from harm. This article examines the concept of patient advocacy and its relevance to nursing, associated goals and outcomes of advocacy and the processes and practices involved. It provides insights into how nurses practise patient advocacy in healthcare settings and how they may develop this role further, through formal education, workplace learning, role modelling by expert nurses and promoting an organisational culture conducive to patient advocacy.

  17. Being a Member of a Self-Advocacy Group: Experiences of Intellectually Disabled People

    Science.gov (United States)

    Gilmartin, Ann; Slevin, Eamonn

    2010-01-01

    A phenomenological methodology was used to explore the lived experiences of belonging to a self-advocacy group for people with intellectual disabilities. Thirteen persons with intellectual disabilities who attend three self-advocacy day centre based groups in a city in the west of Ireland were the sample identified for the study. Changes affected…

  18. Exploration of Undergraduate Preservice Teachers' Experiences Learning Advocacy: A Mixed-Methods Study

    Science.gov (United States)

    Massengale, Kelley; Childers-McKee, Cherese; Benavides, Aerin

    2014-01-01

    Applying transformational critical advocacy research in college instruction can be a powerful way to engage students in challenging inequity in society and promoting positive changes. Few studies systematically measure the impact of such pedagogy on the development of college students' beliefs about advocacy. In this mixed methods study, we…

  19. The Ethics of Evaluation Neutrality and Advocacy.

    Science.gov (United States)

    Datta, Lois-ellin

    1999-01-01

    Examines arguments for and against evaluation advocacy in terms of the American Evaluation Association's "Guiding Principles for Evaluators" and other statements on advocacy and neutrality. Suggests revision of the "Guiding Principles." (Author/SLD)

  20. Research Advocacy at NCI

    Science.gov (United States)

    The patient perspective research advocates brings into NCI’s research enterprise helps to inform research focus and support the dissemination of results that lead to new and better cancer prevention, detection, and treatment methods.

  1. Competition Advocacy: the Italian Experience

    Directory of Open Access Journals (Sweden)

    Salvatore Rebecchini

    2014-07-01

    Full Text Available Competition advocacy is considered, together with enforcement, the core business of an antitrust authority. Broadly speaking there are at least three main tasks regularly performed by most, if not all, antitrust agencies that are amenable to the advocacy function: addressing laws and regulations in order to remove unnecessary impediments to competition; engaging in sector enquiries to understand markets behavior and identify critical issues; explaining the benefits of open competitive markets to the public opinion. This article examines these three main tasks and outlines the challenges for competition agencies, with references to the experience of the Italian Competition Authority (ICA and the initiatives undertaken at international level.

  2. Practitioner Perceptions of School Library Advocacy

    Science.gov (United States)

    Burns, Elizabeth

    2015-01-01

    School library advocacy is increasingly important due to decreases in funding and staff. National organizations attempt to engage school librarians in advocacy and have developed resources and tools to assist with this task. However, there is little research examining how practicing school librarians engage in advocacy and how their advocacy…

  3. Spectropolarimetry of cancer change of biotissues

    Science.gov (United States)

    Yermolenko, Sergey; Ushenko, Alexander; Ivashko, Pavlo; Goudail, François; Gruia, Ion; Gavrilă, Camelia; Zimnyakov, Dmitry; Mikhailova, Alyona

    2009-10-01

    This work is directed to the investigation of the scope of the technique of laser polarimetry and polarization spectrometry of oncological changes of the human prostate tissue under the conditions of multiple scattering. It was shown that the third statistic moment in the intensity distribution proved to be the most sensitive to pathological changes in orientation structure. Its value in the intensity distribution of polarization image I (0 - 90) of oncologically changed tissue is 21 times higher if compared with the similar statistic parameter of the intensity distribution of the healthy tissue. The results of studies of size linear dichroism prostate gland, as healthy and affected by malignant tumor at different stages of its development was presented. Significant difference in the values of linear dichroism and its spectral dependence in the spectral range λ = 280 - 840 nm as between research facilities, and between biotissues - healthy (or affected by benign tumors) and cancer patients was shown. These results may have diagnostic value for detection and assessment of the development of cancer.

  4. Advocacy Networks and Romani Politics in Central and Eastern Europe

    Directory of Open Access Journals (Sweden)

    Peter Vermeersch

    2001-01-01

    Full Text Available This article explores the impact of the activity of international solidarity and human rights organizations on the political involvement of the Roma in Central and Eastern Europe. It will conclude that the increase of an international advocacy network focussing on the plight of the Roma has offered new opportunities to domestic Romani organizations for pressuring governments to change state behaviour or to introduce new policy. In some cases, governments have even appointed Romani personalities from well-known advocacy organizations to advisory positions. However, the influence of a growing advocacy network has not been able yet to create a better democratically elected representation of the Roma in the central arenas of political decision-making on domestic level. Moreover, within domestic Romani movements there is growing discussion about the legitimacy and accountability of Romani advisors.

  5. Advocacy and policy issues Tutorial 2

    CERN Document Server

    CERN. Geneva

    2007-01-01

    This tutorial is aimed at those who are new to the area of repositories and who want to learn more about key advocacy and policy issues. The tutorial will include information and advice on putting together an institutional advocacy campaign and developing policies for your repository. There will be opportunities for participants to share experiences and to ask questions. The tutorial will include a practical exercise in developing an advocacy presentation. Participants with experience of advocacy are welcome to attend the session to share their experiences, but should bear in mind that it is aimed primarily at those looking for help and advice in advocacy matters.

  6. Aging and Cancer Mortality: Dynamics of Change and Sex Differences

    OpenAIRE

    Yang, Yang; Li, Ting; Nielsen, Matthew E.

    2012-01-01

    Age-related changes in cancer mortality risk are important for understanding the processes of disease and aging interaction. The extent to which these age changes differ by sex further contributes to this understanding but has not been well studied to date. We conducted a systematic examination of dynamics and heterogeneity of age changes in cancer mortality rates for the top 14 cancer sites using vital statistics from the NCHS and SEER between 1969 and 2007. We assessed patterns of age chang...

  7. Cancer type-specific epigenetic changes: gastric cancer.

    Science.gov (United States)

    Calcagno, Danielle Queiroz; de Arruda Cardoso Smith, Marília; Burbano, Rommel Rodriguez

    2015-01-01

    Gastric cancer (GC) remains a major cause of mortality despite declining rate in the world. Epigenetic alterations contribute significantly to the development and progression of gastric tumors. Epigenetic refers to the number of modifications of the chromatin structure that affect gene expression without altering the primary sequence of DNA, and these changes lead to transcriptional activation or silencing of the gene. Over the years, the study of epigenetic processes has increased, and novel therapeutic approaches have emerged. This chapter summarizes the main epigenomic mechanisms described recently involved in gastric carcinogenesis, focusing on the roles that aberrant DNA methylation, histone modifications (histone acetylation and methylation), and miRNAs (oncogenic and tumor suppressor function of miRNA) play in the onset and progression of gastric tumors. Clinical implications of these epigenetic alterations in GC are also discussed.

  8. Self-reported evaluation of competencies and attitudes by physicians-in-training before and after a single day legislative advocacy experience

    Directory of Open Access Journals (Sweden)

    Huntoon Kristin M

    2012-06-01

    Full Text Available Abstract Background Advocacy is increasingly being recognized as a core element of medical professionalism and efforts are underway to incorporate advocacy training into graduate and undergraduate medical school curricula. While limited data exist to quantify physician attitudes toward advocacy, even less has been done to assess the knowledge, skills, and attitudes of future physicians. The purpose of this study was to assess students’ experiences and attitudes toward legislative advocacy, cutting out using a convience sample. Methods A paper survey based on previously validated surveys was administered to a convenience sample of premedical and medical student participants attending a National Advocacy Day in Washington, DC, in March 2011, both before and after their advocacy experiences. Responses were anonymous and either categorical ( or ordinal, using a 5-point Likert scale. Data were analyzed statistically to evaluate demographics and compare changes in pre- and post-experience attitude and skills. Results Data from 108 pre-advocacy and 50 post-advocacy surveys were analyzed yielding a response rate of 46.3%. Following a single advocacy experience, subjects felt they were more likely to contact their legislators about healthcare issues (p = 0.03, to meet in person with their legislators (p  Conclusions A one-time practical advocacy experience has a positive influence on students’ knowledge, skills and attitudes towards legislative advocacy. Practical experience is an important method of furthering medical education in advocacy and further research is necessary to assess its impact in a broader population.

  9. Reducing violent injuries: priorities for pediatrician advocacy.

    Science.gov (United States)

    Dolins, J C; Christoffel, K K

    1994-10-01

    A basic framework for developing an advocacy plan must systematically break down the large task of policy development implementation into manageable components. The basic framework described in detail in this paper includes three steps: Setting policy objectives by narrowing the scope of policy, by reviewing policy options, and by examining options against selected criteria. Developing strategies for educating the public and for approaching legislative/regulatory bodies. Evaluating the effectiveness of the advocacy action plan as a process and as an agent for change. To illustrate the variety of ways in which pediatricians can be involved in the policy process to reduce violent injuries among children and adolescents, we apply this systematic approach to three priority areas. Prohibiting the use of corporal punishment in schools is intended to curb the institutionalized legitimacy of violence that has been associated with future use of violence. Efforts to remove handguns from the environments of children and adolescents are aimed at reducing the numbers of firearm injuries inflicted upon and by minors. Comprehensive treatment of adolescent victims of assault is intended to decrease the reoccurrence of violent injuries.

  10. Advocacy and education in Wisconsin

    International Nuclear Information System (INIS)

    Wisconsin's Radioactive Waste Review Board is required by law to advocate for and educate the public on the high-level nuclear waste issue. The goal of its education program is to empower people by giving them information and skills. Environmental advocacy and public activism are part of the State's Progressive political tradition. The Board seeks and uses public input while developing education programs, and helps local areas organize committees to develop their own programs

  11. Gastric cancer in Scotland: changing epidemiology, unchanging workload.

    OpenAIRE

    Sedgwick, D M; Akoh, J A; Macintyre, I. M.

    1991-01-01

    OBJECTIVE--To determine the changes in incidence of and mortality from gastric cancer in Scotland between 1978 and 1987 and in the operative workload in Lothian between 1979 and 1988. DESIGN--Analysis of national incidence statistics for gastric cancer derived from the Scottish national cancer registry, deaths from gastric cancer recorded by the registrar general for Scotland, and Lothian surgical audit data. SETTING--Scotland and Lothian Health Board area. PATIENTS--Patients in Scotland with...

  12. Cancer prevention through stealth: science, policy advocacy, and multilevel governance in the establishment of a "National Tobacco Control Regime" in the United States.

    Science.gov (United States)

    Studlar, Donley T

    2014-06-01

    The role of the US federal government in developing tobacco control through a cooperative, interactive program with state and local private and public organizations has been underestimated. This article investigates how the government initiated and sustained a program of "capacity building" through the scientific authority of the National Cancer Institute, beginning in the 1980s. There are several major questions to be answered: (1) How did this program manage to be adopted and sustained despite the well-documented hindrances to effective tobacco control policy at the federal level? (2) How did a tobacco control policy program become incorporated into the scientific research agenda of the National Cancer Institute? (3) How have science, social factors, and government at various levels interacted in this capacity-building program? The study emphasizes how the US federal government, blocked by a tobacco-friendly Congress from enacting effective tobacco control legislation, utilized its scientific research role and, with the cooperation of other levels of government and large, private antitobacco organizations, established an ongoing policy effort. PMID:24879831

  13. Advocacy 201: Incorporating Advocacy Training in Health Education Professional Preparation Programs

    Science.gov (United States)

    Thompson, Amy; Kerr, Dianne; Dowling, Jamie; Wagner, Laurie

    2012-01-01

    Involvement in advocacy is a responsibility of health educators, as identified by the National Commission on Health Education Credentialing. Of all the professional responsibilities, participation in advocacy-related activity is often neglected. This lack of participation may be due to the absence of advocacy and policy skills training in health…

  14. 78 FR 73586 - Taxpayer Advocacy Panel Meeting Cancellation

    Science.gov (United States)

    2013-12-06

    ... Internal Revenue Service Taxpayer Advocacy Panel Meeting Cancellation AGENCY: Internal Revenue Service (IRS... the open meeting of the Taxpayer Advocacy Panel Taxpayer Assistance Center Improvements Project..., Taxpayer Advocacy Panel. BILLING CODE 4830-01-P...

  15. 78 FR 73587 - Taxpayer Advocacy Panel Meeting Cancellation

    Science.gov (United States)

    2013-12-06

    ... Internal Revenue Service Taxpayer Advocacy Panel Meeting Cancellation AGENCY: Internal Revenue Service (IRS... the open meeting of the Taxpayer Advocacy Panel Notices and Correspondence Project Committee scheduled... Advocacy Panel. BILLING CODE 4830-01-P...

  16. 78 FR 73587 - Taxpayer Advocacy Panel; Meeting Cancellation.

    Science.gov (United States)

    2013-12-06

    ... Internal Revenue Service Taxpayer Advocacy Panel; Meeting Cancellation. AGENCY: Internal Revenue Service... cancellation of the open meeting of the Taxpayer Advocacy Panel Taxpayer Communications Project Committee..., Acting Director, Taxpayer Advocacy Panel. BILLING CODE 4830-01-P...

  17. Experiencing existential changes: the lived experience of having cancer.

    Science.gov (United States)

    Halldorsdottir, S; Hamrin, E

    1996-02-01

    This phenomenological study was designed to explore the lived experience of having cancer, as perceived by people who have been diagnosed and treated for cancer. The aim of the study was to add to the knowledge and understanding of this complex human phenomenon. Data were collected through in-depth interviews with nine people who were in the remission or recovery phase of cancer. The interviews were tape-recorded and transcribed verbatim for each participant. Through intersubjective interactions and thematic analysis, the essential description of the lived experience of having cancer was constructed. The overriding theme of the lived experience of having cancer is "experiencing existential changes." Five basic subthemes were identified in the participants accounts, all of which are part of the existential changes involved in the lived experience of having cancer. These are: uncertainty, vulnerability, isolation, discomfort, and redefinition. The study can increase the understanding of what it is like to have cancer.

  18. Genetic changes in nonepithelial ovarian cancer.

    Science.gov (United States)

    Van Nieuwenhuysen, Els; Lambrechts, Sandrina; Lambrechts, Diether; Leunen, Karin; Amant, Frédéric; Vergote, Ignace

    2013-07-01

    Nonepithelial ovarian cancers (OCs), including sex cord-stromal tumors (SCSTs) and germ cell tumors (GCTs), are an uncommon subset of OC, together accounting for 10% of all OCs. The etiology of these tumors remains largely unresolved. It is well established that tumorigenesis is the result of multiple genetic alterations driving a normal cell toward a malignant state. Much effort has been made into researching the molecular mechanisms underlying epithelial OC, but far less is known about the genetic changes in SCSTs and GCTs. Recently, a single point missense mutation (C134W) was found in the FOXL2 gene in approximately 95% of adult-type granulosa cell tumors, suggesting a key role for FOXL2 in these tumors. By contrast, the FOXL2 mutation was not found in the juvenile type. DICER1 somatic missense mutations were found in approximately 60% of Sertoli-Leydig tumors. Ovarian GCTs share many morphological features and a similar pattern of chromosomal alterations with testicular GCTs. In the latter, recent genome-wide association studies have identified seven susceptibility loci near KITLG, SPRY4, UKC2, BAK1, DMRT1, TERT and ATF7IP. All of the susceptibility loci detected thus far are all involved in primordial germ cell function or sex determination. TGF-β/BMP and Wnt/β-catenin signaling was absent in dysgerminomas, but present in yolk sac tumors, suggesting intertumoral heterogeneity. In this article, the authors aim to provide an overview of the current knowledge on the possible molecular changes in SCSTs and GCTs of the ovary. PMID:23875665

  19. Advocacy: AASL Puts the Puzzle Together

    Science.gov (United States)

    Johns, Sara Kelly

    2007-01-01

    School librarians work with people of all ages, abilities, and personalities; those people are the puzzle pieces that make advocacy for libraries effective. School librarians contribute to and use the resources of their state and national organizations' advocacy efforts. The completed picture of the puzzle is an excellent program with…

  20. Building Evidence for Music Education Advocacy

    Science.gov (United States)

    Shorner-Johnson, Kevin

    2013-01-01

    The economic challenges facing public schools and music education are immense. In this context, music teachers and supporters will need to engage in persuasive advocacy to protect resource allocations to music programs. It is worthwhile to consider the model of music education advocacy that allowed music to be adopted into the Boston Public…

  1. Autism Advocacy: A Network Striving for Equity

    Science.gov (United States)

    Itkonen, Tiina; Ream, Robert

    2013-01-01

    In this exploratory case study, we examine the rise of autism on the policy agenda and the new generation of autism advocacy. We focus especially on interconnections between the rhetoric about autism in the media and the emergence and political effectiveness of Autism Speaks, the nation's largest autism advocacy group. We portray how…

  2. 45 CFR 1321.13 - Advocacy responsibilities.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Advocacy responsibilities. 1321.13 Section 1321.13 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES... AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.13 Advocacy responsibilities....

  3. Professor Brand Advocacy: Do Brand Relationships Matter?

    Science.gov (United States)

    Jillapalli, Ravi K.; Wilcox, James B.

    2010-01-01

    The trend among students to advocate their professors online continues to generate interest within marketing academia. Brand advocacy in products and services has played a vital role in marketing. However, no known research to date has embraced the idea of brand advocacy in marketing education. This research builds on the recent human brand…

  4. Advocacy for Development: Effectiveness, Monitoring and Evaluation

    NARCIS (Netherlands)

    Barrett, J.B.; Wessel, van M.G.J.; Hilhorst, D.J.M.

    2016-01-01

    Monitoring and evaluation of advocacy for development is an emerging field. Many CSOs, donors and evaluators are now involved with advocacy. Questions of how to understand and assess programmes are urgent. This e-book seeks to contribute to practical capacity on this front on the basis of lessons le

  5. The Changing Landscape of Lung Cancer Research and Treatment

    Science.gov (United States)

    Along with the Lung Cancer Social Media (#LCSM) community, the National Cancer Institute will be co-hosting a lively and interactive Google Hangout on Air about the changing landscape of lung cancer research and treatment. During the chat, viewers will have the opportunity to pose questions to a panel of lung cancer experts including NCI's Dr. Shakun Malik, the head of thoracic oncology therapeutics, Roy S. Herbst, MD, PhD, Chief of Medical Oncology, Yale Cancer Center and Smilow Cancer Hospital at Yale-New Haven and David Tom Cooke MD FACS, Head, Section of General Thoracic Surgery University of California, Davis. You can also learn more and follow along on the #LCSM Chat page. The chat will be moderated by lung cancer advocate and #LCSM co-founder, Janet Freeman-Daily. To ask questions of our experts, simply use the #LCSM hashtag during the chat.

  6. Cytologic changes of ovarian epithelial cancer induced by neoadjuvant chemotherapy

    OpenAIRE

    Wang, Yiying; Wang, Yue; Zheng, Wenxin

    2013-01-01

    Objective: Neoadjuvant chemotherapy (NACT) followed by cytoreduction has now become a part of standard care for patients with advanced ovarian cancer. Cytologic changes of the cancer cells induced by NACT, however, sometimes may cause confusion in terms of pathologic diagnosis and therefore inappropriate management. The objective of this study was to characterize the histologic or cytologic features of the ovarian cancers from those patients who received NACT in order to improve the diagnosti...

  7. Quality measurement and system change of cancer care delivery.

    Science.gov (United States)

    Haggstrom, David A; Doebbeling, Bradley N

    2011-12-01

    Cancer care quality measurement and system change may serve as a case example for larger possibilities in the health care system related to other diseases. Cancer care quality gaps and variation exist across both technical and patient-centered cancer quality measures, especially among vulnerable populations. There is a need to develop measures that address the following dimensions of quality and its context: disparities, overuse, patient-centeredness, and uncertainty. Developments that may promote system change in cancer care delivery include changes in the information market, organizational accountability, and consumer empowerment. Information market changes include public cancer care quality reporting, enabled by health information exchange, and incentivized by pay-for-performance. Moving organizational accountability, reimbursement, and quality measurement from individual episodes of care to multiple providers providing coordinated cancer care may address quality gaps associated with the fragmentation of care delivery. Consumer empowerment through new technologies, such as personal health records, may lead to the collection of patient-centered quality measures and promote patient self-management. Across all of these developments, leadership and ongoing research to guide informed system changes will be necessary to transform the cancer care delivery system.

  8. Succeeding in Postsecondary Ed through Self-Advocacy.

    Science.gov (United States)

    Lock, Robin H.; Layton, Carol A.

    2001-01-01

    Discussion of self-advocacy for postsecondary students with learning disabilities considers learning characteristics, self-advocacy as a critical transition skill, identification of intrinsic processing abilities, developing a self-advocacy plan, and the increasing need for postsecondary accommodations. Insets include a sample self-advocacy plan,…

  9. Community-based participatory research: a capacity-building approach for policy advocacy aimed at eliminating health disparities.

    Science.gov (United States)

    Israel, Barbara A; Coombe, Chris M; Cheezum, Rebecca R; Schulz, Amy J; McGranaghan, Robert J; Lichtenstein, Richard; Reyes, Angela G; Clement, Jaye; Burris, Akosua

    2010-11-01

    There have been increasing calls for community-academic partnerships to enhance the capacity of partners to engage in policy advocacy aimed at eliminating health disparities. Community-based participatory research (CBPR) is a partnership approach that can facilitate capacity building and policy change through equitable engagement of diverse partners. Toward this end, the Detroit Community-Academic Urban Research Center, a long-standing CBPR partnership, has conducted a policy training project. We describe CBPR and its relevance to health disparities; the interface between CBPR, policy advocacy, and health disparities; the rationale for capacity building to foster policy advocacy; and the process and outcomes of our policy advocacy training. We discuss lessons learned and implications for CBPR and policy advocacy to eliminate health disparities. PMID:20864728

  10. Prevention of Cancer Through Lifestyle Changes

    Directory of Open Access Journals (Sweden)

    R. James Barnard

    2004-01-01

    Full Text Available Cancer is the second leading cause of death in the USA and an abundance of evidence suggests that lifestyle factors including smoking, the typical high-fat, refined-sugar diet and physical inactivity account for the majority of cancer. This review focuses on diet and inactivity as major factors for cancer promotion by inducing insulin resistance and hyperinsulinemia. Elevated levels of serum insulin impact on the liver primarily, increasing the production of insulin-like growth factor I (IGF-I while reducing the production of insulin-like growth factor binding protein 1 (IGFBP-1 resulting in stimulation of tumor cell growth and inhibition of apoptosis (programmed cell death. Adopting a diet low in fat and high in fiber-rich starch foods, which would also include an abundance of antioxidants, combined with regular aerobic exercise might control insulin resistance, reduce the resulting serum factors and thus reduce the risk for many different cancers commonly seen in the USA.

  11. Community Health Worker Professional Advocacy: Voices of Action from the 2014 National Community Health Worker Advocacy Survey.

    Science.gov (United States)

    Sabo, Samantha; Wennerstrom, Ashley; Phillips, David; Haywoord, Catherine; Redondo, Floribella; Bell, Melanie L; Ingram, Maia

    2015-01-01

    This mixed-methods study explores community health worker (CHW) engagement in professional advocacy. Data from the National Community Health Worker Advocacy Survey (n = 1661) assessed the relationship between CHW professional advocacy and CHW demographics, and work characteristics. Qualitative data articulated the quality of professional advocacy efforts. Approximately, 30% of CHW respondents advocated for professional advancement or collaborated with other CHWs to advance the workforce. Advocacy was more prevalent among CHWs affiliated with a professional network. CHW advocacy targeted recognition of the field, appropriate training and compensation, and sustainable funding. CHW professional advocacy is imperative to advancement of the field.

  12. Promoting changes in diet and physical activity in breast and colorectal cancer screening settings: an unexplored opportunity for endorsing healthy behaviors.

    Science.gov (United States)

    Anderson, Annie S; Mackison, Dionne; Boath, Callum; Steele, Robert

    2013-03-01

    The importance of diet, physical activity, and weight management in breast and colorectal cancer prevention is widely recognized. While there may be many "teachable moments" that could be used to assess and initiate changes in these behaviors by health professionals (to complement public health campaigns), there is little evidence that lifestyle is discussed within cancer screening settings. The lack of advocacy about lifestyle in these settings may endorse poor health behaviors, in particular the absence of guidance to visibly obese patients. To fully use the teachable moment, patients need to be aware of the relationship between diet and physical activity and the risk of cancer and to be able to relate guidance to personal behaviors. Results from cardiovascular and diabetes prevention programs provide evidence about the components of effective behavior change programs which could be used in the screening setting. Findings from interventions initiated in the colorectal cancer screening setting suggest that such programs can be delivered but it is not clear how acceptable these are in routine health services. Effective interventions delivered in this setting also offer an important opportunity to contribute to the reduction of the overall burden of chronic non-communicable diseases. PMID:23324132

  13. 议联盟框架视角下我国计划生育政策变迁分析%An Analysis of the Changes in China’s Family Planning Policy From the Perspective of the Advocacy Coalition Framework

    Institute of Scientific and Technical Information of China (English)

    崔开华; 徐菡; 蒋文丽

    2015-01-01

    The Advocacy Coalition Framework,a replacement for policy stage theory,has long been used in analyzing policy changes in western countries. Based on the Advocacy Coalition Framework,this paper analyzes the three phases of the change of China’s family planning policy: the exploration phase when PRC was first founded,1970s when the policy was under formulation and 1980s when the policy was completed and launched. With the analysis we test the practicability of Advocacy Coalition Framework in interpreting China’s public policy change. Although there exist some problems in its interpretation of the change process of China’s family planning policy due to political and social differences,Advocacy Coalition Framework still provides us with a new way to understand policy change.%倡议联盟框架作为对政策阶段论的替代,在西方国家用来分析政策变迁已经有较长的历史。本文紧扣我国计划生育政策变迁这一社会热点问题,在介绍倡议联盟框架基本结构的基础上,分析了我国计划生育政策变迁的三个阶段——新中国成立之初的探索阶段、20世纪70年代的基本形成阶段以及20世纪80年代政策出台和完善阶段的基本情况,并用倡议联盟框架的基本理论探讨和研究我国计划生育政策的变迁过程,检验倡议联盟框架对我国公共政策变迁的解释性和实用性。当然,由于政治和社会环境的差异,倡议联盟框架对我国计划生育政策变迁过程的解释存在一些不足,但是仍然为人们提供了一个理解政策变迁过程的新途径。

  14. Epigenetic changes in virus-associated human cancers

    Institute of Scientific and Technical Information of China (English)

    Hsin Pai LI; Yu Wei LEU; Yu Sun CHANG

    2005-01-01

    Epigenetics of human cancer becomes an area of emerging research direction due to a growing understanding of specific epigenetic pathways and rapid development of detection technologies. Aberrant promoter hypermethylation is a prevalent phenonmena in human cancers. Tumor suppressor genes are often hypermethylated due to the increased activity or deregulation of DNMTs. Increasing evidence also reveals that viral genes are one of the key players in regulating DNA methylation. In this review, we will focus on hypermethylation and tumor suppressor gene silencing and the signal pathways that are involved, particularly in cancers closely associated with the hepatitis B virus, simian virus 40 (SV40), and Epstein-Barr virus. In addition, we will discuss current technologies for genome-wide detection of epigenetically regulated targets, which allow for systematic DNA hypermethylation analysis. The study of epigenetic changes should provide a global view of gene profile in cancer, and epigenetic markers could be used for early detection,prognosis, and therapy of cancer.

  15. Characterizing metabolic changes in human colorectal cancer.

    Science.gov (United States)

    Williams, Michael D; Zhang, Xing; Park, Jeong-Jin; Siems, William F; Gang, David R; Resar, Linda M S; Reeves, Raymond; Hill, Herbert H

    2015-06-01

    Colorectal cancer (CRC) remains a leading cause of cancer death worldwide, despite the fact that it is a curable disease when diagnosed early. The development of new screening methods to aid in early diagnosis or identify precursor lesions at risk for progressing to CRC will be vital to improving the survival rate of individuals predisposed to CRC. Metabolomics is an advancing area that has recently seen numerous applications to the field of cancer research. Altered metabolism has been studied for many years as a means to understand and characterize cancer. However, further work is required to establish standard procedures and improve our ability to identify distinct metabolomic profiles that can be used to diagnose CRC or predict disease progression. The present study demonstrates the use of direct infusion traveling wave ion mobility mass spectrometry to distinguish metabolic profiles from CRC samples and matched non-neoplastic epithelium as well as metastatic and primary tumors at different stages of disease (T1-T4). By directly infusing our samples, the analysis time was reduced significantly, thus increasing the speed and efficiency of this method compared to traditional metabolomics platforms. Partial least squares discriminant analysis was used to visualize differences between the metabolic profiles of sample types and to identify the specific m/z features that led to this differentiation. Identification of the distinct m/z features was made using the human metabolome database. We discovered alterations in fatty acid biosynthesis and oxidative, glycolytic, and polyamine pathways that distinguish tumors from non-malignant colonic epithelium as well as various stages of CRC. Although further studies are needed, our results indicate that colonic epithelial cells undergo metabolic reprogramming during their evolution to CRC, and the distinct metabolites could serve as diagnostic tools or potential targets in therapy or primary prevention. Graphical Abstract

  16. The Changing World of Breast Cancer: A Radiologist's Perspective.

    Science.gov (United States)

    Kuhl, Christiane K

    2016-01-01

    Compared with other fields of medicine, there is hardly an area that has seen such fast development as the world of breast cancer. Indeed, the way we treat breast cancer has changed fundamentally over the past decades. Breast imaging has always been an integral part of this change, and it undergoes constant adjustment to new ways of thinking. This relates not only to the technical tools we use for diagnosing breast cancer but also to the way diagnostic information is used to guide treatment. There is a constant change of concepts for and attitudes toward breast cancer, and a constant flux of new ideas, new treatment approaches, and new insights into the molecular and biological behavior of this disease. Clinical breast radiologists and even more so, clinician scientists, interested in breast imaging need to keep abreast with this rapidly changing world. Diagnostic or treatment approaches that are considered useful today may be abandoned tomorrow. Approaches that seem irrelevant or far too extravagant today may prove clinically useful and adequate next year. Radiologists must constantly question what they do, and align their clinical aims and research objectives with the changing needs of contemporary breast oncology. Moreover, knowledge about the past helps better understand present debates and controversies. Accordingly, in this article, we provide an overview on the evolution of breast imaging and breast cancer treatment, describe current areas of research, and offer an outlook regarding the years to come. PMID:26933985

  17. The Changing World of Breast Cancer: A Radiologist's Perspective.

    Science.gov (United States)

    Kuhl, Christiane K

    2015-09-01

    Compared with other fields of medicine, there is hardly an area that has seen such fast development as the world of breast cancer. Indeed, the way we treat breast cancer has changed fundamentally over the past decades. Breast imaging has always been an integral part of this change, and it undergoes constant adjustment to new ways of thinking. This relates not only to the technical tools we use for diagnosing breast cancer but also to the way diagnostic information is used to guide treatment. There is a constant change of concepts for and attitudes toward breast cancer, and a constant flux of new ideas, new treatment approaches, and new insights into the molecular and biological behavior of this disease. Clinical breast radiologists and even more so, clinician scientists, interested in breast imaging need to keep abreast with this rapidly changing world. Diagnostic or treatment approaches that are considered useful today may be abandoned tomorrow. Approaches that seem irrelevant or far too extravagant today may prove clinically useful and adequate next year. Radiologists must constantly question what they do, and align their clinical aims and research objectives with the changing needs of contemporary breast oncology. Moreover, knowledge about the past helps better understand present debates and controversies. Accordingly, in this article, we provide an overview on the evolution of breast imaging and breast cancer treatment, describe current areas of research, and offer an outlook regarding the years to come.

  18. A New Movement in an Old Bureaucracy: The Development of Self-Advocacy in the Czech Republic

    Science.gov (United States)

    Siska, Jan

    2006-01-01

    In this paper I describe how self-advocacy has grown in the Czech Republic. First, I talk about how services for people with learning disabilities have begun to change in the last few years. This is because voluntary groups have lobbied and campaigned for change. I learned about self-advocacy during a visit to the UK in the 1990s. I went back to…

  19. The Changing Face of Esophageal Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Melhado, Rachel E., E-mail: raye732001@yahoo.co.uk; Alderson, Derek; Tucker, Olga [Academic Department of Surgery, Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham (United Kingdom)

    2010-06-28

    The two main histological esophageal cancer types, adenocarcinoma and squamous cell carcinoma, differ in incidence, geographic distribution, ethnic pattern and etiology. This article focuses on epidemiology with particular reference to geographic and temporal variations in incidence, along with a review of the evidence supporting environmental and genetic factors involved in esophageal carcinogenesis. Squamous cell carcinoma of the esophagus remains predominantly a disease of the developing world. In contrast, esophageal adenocarcinoma is mainly a disease of western developed societies, associated with obesity and gastro-esophageal reflux disease. There has been a dramatic increase in the incidence of adenocarcinoma in developed countries in parallel with migration of both esophageal and gastric adenocarcinomas towards the gastro-esophageal junction.

  20. Advocacy in the Western Hemisphere Region: some FPA success stories.

    Science.gov (United States)

    Andrews, D J

    1996-01-01

    The International Planned Parenthood Federation's Vision 2000 Strategic Plan has emphasized advocacy and the training of family planning associations (FPAs) in the Western Hemisphere region. During the summer of 1995 training programs in advocacy leadership management were sponsored for six FPAs in the Bahamas, Suriname, Belize, Colombia, Honduras, and Brazil. At the Western Hemisphere Regional Council Meeting in September 1995 awards were presented to FPAs for media outstanding projects. These FPAs used outreach to the community to promote the goals of Vision 2000. The Bahamas FPA won the Rosa Cisneros Award for articles published in a magazine that is distributed in primary and secondary schools and deals with the activities, achievements, and opinions of students. Issues include: love, relationships, responsibility, and teen pregnancy. A weekly television talk show also addresses the issues facing youth including education, music, community work, sexuality, pregnancy, and the relationship between teenagers and adults. The Family Planning Association of Honduras was also nominated for the award for a radio show on the health of mothers and children, the problems of adolescents, and FP. The newspaper Tiempo received the award for feature articles on social issues and FP. In 1994 the Association distributed thousands of booklets on contraceptives as well as fliers on vasectomy, female sterilization, oral contraceptives, IUDs, condoms, responsible parenthood, high-risk pregnancy, vaginal cytology, and cervical cancer. Similar posters were placed in hospitals and health centers, in 1997 FP posts, and 400 commercial outlets. The Family Planning Association of Suriname also carried out an impressive advocacy program during the period of 1968-93 with the goals of establishing a balance between population growth and the available resources to achieve well-being with regard to education, health care, nutrition, and housing. PMID:12291093

  1. Gender and advocacy in Indonesia.

    Science.gov (United States)

    Ray-ross, S

    1997-01-01

    The Centre for Development and Population Activities (CEDPA) and the Indonesian Midwives Association (IBI) have developed a two-phase training program regarding gender issues for the association's midwives. The first phase focuses on the leadership, management, and advocacy skills necessary to articulate program needs and to take part in making decisions regarding family planning and reproductive health. The second phase concerns the integration of gender into project design. Proposals developed by the midwives include the following: 1) to improve counseling services for women in a district where 70% of the women using contraception do not decide for themselves which methods to use; 2) to reduce maternal mortality in a district where it has increased by 20% and where women have died while waiting for husbands or fathers-in-law to make the decision to bring them to hospitals; 3) to develop gender-sensitive materials concerning HIV/AIDS; and 4) to expand gender training to all levels of IBI, to provide follow-up technical support, and to integrate gender into the mission statement of the organization. Dr. Nafsiah Mboi (member of Parliament and vice chair of the Global Commission on Women's Health), Dr. Widyastuti Wibisana (director of community participation in the Ministry of Health), Dr. Kokila Vaidya (WHO Medical Officer), Carla Bianpoen (gender specialist with the World Bank), and Titi Sumbung (director of the Melati Foundation) helped to develop and to conduct the program. IBI, which has 65,000 members, provides family planning, reproductive health, and maternal and child health services throughout Indonesia. PMID:12292791

  2. Advocacy for active transport: advocate and city council perspectives

    OpenAIRE

    Rosenby Marieah; Reeder Anthony I; Murdoch Linda; Richards Rosalina

    2010-01-01

    Abstract Background Effective advocacy is an important part of efforts to increase population participation in physical activity. Research about effective health advocacy is scarce, however, the health sector can learn from the experiences and knowledge of community advocates and those who are on the receiving end of this advocacy. The aim of this study is to explore advocacy for active transport from the perspectives of community advocates and representatives from City councils. Methods Cycl...

  3. Changes in NAD/ADP-ribose metabolism in rectal cancer

    Directory of Open Access Journals (Sweden)

    L. Yalcintepe

    2005-03-01

    Full Text Available The extent of ADP-ribosylation in rectal cancer was compared to that of the corresponding normal rectal tissue. Twenty rectal tissue fragments were collected during surgery from patients diagnosed as having rectal cancer on the basis of pathology results. The levels of ADP-ribosylation in rectum cancer tissue samples (95.9 ± 22.1 nmol/ml was significantly higher than in normal tissues (11.4 ± 4 nmol/ml. The level of NAD+ glycohydrolase and ADP-ribosyl cyclase activities in rectal cancer and normal tissue samples were measured. Cancer tissues had significantly higher NAD+ glycohydrolase and ADP-ribosyl cyclase activities than the control tissues (43.3 ± 9.1 vs 29.2 ± 5.2 and 6.2 ± 1.6 vs 1.6 ± 0.4 nmol mg-1 min-1. Approximately 75% of the NAD+ concentration was consumed as substrate in rectal cancer, with changes in NAD+/ADP-ribose metabolism being observed. When [14C]-ADP-ribosylated tissue samples were subjected to SDS-PAGE, autoradiographic analysis revealed that several proteins were ADP-ribosylated in rectum tissue. Notably, the radiolabeling of a 113-kDa protein was remarkably greater than that in control tissues. Poly(ADP-ribosylation of the 113-kDa protein in rectum cancer tissues might be enhanced with its proliferative activity, and poly(ADP-ribosylation of the same protein in rectum cancer patients might be an indicator of tumor diagnosis.

  4. Examining School Counselors' Commitments to Social Justice Advocacy

    Science.gov (United States)

    Feldwisch, Rachel P.

    2016-01-01

    Many school counselors endorse using social justice advocacy to close achievement gaps. In this study, school counselors from a single state scored in the moderate to high range on the Social Issues Advocacy Scale. Results showed alignment between school counselors' self-endorsement of social justice advocacy and scores on the Advocacy…

  5. Development and Assessment of the Social Issues Advocacy Scale

    Science.gov (United States)

    Nilsson, Johanna E.; Marszalek, Jacob M.; Linnemeyer, Rachel M.; Bahner, Angela D.; Misialek, Leah Hanson

    2011-01-01

    This article describes the development and the initial psychometric evaluation of the Social Issues Advocacy Scale in two studies. In the first study, an exploratory factor analysis (n = 278) revealed a four-factor scale, accounting for 71.4% of the variance, measuring different aspects of social issue advocacy: Political and Social Advocacy,…

  6. 77 FR 13390 - Recruitment Notice for the Taxpayer Advocacy Panel

    Science.gov (United States)

    2012-03-06

    ... Internal Revenue Service Recruitment Notice for the Taxpayer Advocacy Panel AGENCY: Internal Revenue... Advocacy Panel (TAP) Members. DATES: March 19, 2012 through April 27, 2012. FOR FURTHER INFORMATION CONTACT... nation's tax agency by applying to be members of the Taxpayer Advocacy Panel (TAP). The mission of...

  7. 76 FR 69799 - Open meeting of the Taxpayer Advocacy Panel

    Science.gov (United States)

    2011-11-09

    ... Internal Revenue Service Open meeting of the Taxpayer Advocacy Panel AGENCY: Internal Revenue Service (IRS) Treasury. ACTION: Notice of meeting. SUMMARY: An open meeting of the Taxpayer Advocacy Panel will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas, and suggestions on...

  8. 76 FR 12418 - Recruitment Notice for the Taxpayer Advocacy Panel

    Science.gov (United States)

    2011-03-07

    ... Internal Revenue Service Recruitment Notice for the Taxpayer Advocacy Panel AGENCY: Internal Revenue... Advocacy Panel (TAP) Members. DATES: March 14, 2011 through April 29, 2011. FOR FURTHER INFORMATION CONTACT... nation's tax agency by applying to be members of the Taxpayer Advocacy Panel (TAP). The mission of...

  9. 77 FR 16895 - Taxpayer Advocacy Panel Meeting Cancellation

    Science.gov (United States)

    2012-03-22

    ... Internal Revenue Service Taxpayer Advocacy Panel Meeting Cancellation AGENCY: Internal Revenue Service (IRS... the open meeting of the Taxpayer Advocacy Panel Taxpayer Burden Reduction Project Committee scheduled... cancelled pending renewal of the Taxpayer Advocacy Panel Charter. FOR FURTHER INFORMATION CONTACT: Audrey...

  10. 75 FR 68403 - Open meeting of the Taxpayer Advocacy Panel

    Science.gov (United States)

    2010-11-05

    ... Internal Revenue Service Open meeting of the Taxpayer Advocacy Panel AGENCY: Internal Revenue Service (IRS) Treasury. ACTION: Notice of meeting. SUMMARY: An open meeting of the Taxpayer Advocacy Panel will be conducted. The Taxpayer Advocacy Panel is soliciting public comment, ideas, and suggestions on...

  11. 76 FR 75951 - Taxpayer Advocacy Panel Meeting Cancellation

    Science.gov (United States)

    2011-12-05

    ... Internal Revenue Service Taxpayer Advocacy Panel Meeting Cancellation AGENCY: Internal Revenue Service (IRS... the open meeting of the Taxpayer Advocacy Panel scheduled for Tuesday, December 6, 2011, and Wednesday.... ] Dated: November 30, 2011. Shawn Collins, Director, Taxpayer Advocacy Panel. BILLING CODE 4830-01-P...

  12. 78 FR 13157 - Recruitment Notice for the Taxpayer Advocacy Panel

    Science.gov (United States)

    2013-02-26

    ... Internal Revenue Service Recruitment Notice for the Taxpayer Advocacy Panel AGENCY: Internal Revenue... Advocacy Panel (TAP) Members. DATES: February 22, 2013, through April 1, 2013. FOR FURTHER INFORMATION... individuals to help improve the nation's tax agency by applying to be members of the Taxpayer Advocacy...

  13. 75 FR 9028 - Recruitment Notice for the Taxpayer Advocacy Panel

    Science.gov (United States)

    2010-02-26

    ... Internal Revenue Service Recruitment Notice for the Taxpayer Advocacy Panel AGENCY: Internal Revenue... Advocacy Panel (TAP) Members. DATES: March 15, 2010 through April 30, 2010. FOR FURTHER INFORMATION CONTACT... nation's tax agency by applying to be members of the Taxpayer Advocacy Panel (TAP). The mission of...

  14. 78 FR 24694 - Family Advocacy Command Assistance Team (FACAT)

    Science.gov (United States)

    2013-04-26

    ... of the Secretary 32 CFR Part 60 RIN 0790-AI40 Family Advocacy Command Assistance Team (FACAT) AGENCY... prescribe procedures for implementation and use of the multi-disciplinary Family Advocacy Command Assistant... establishes a DoD multi-disciplinary Family Advocacy Command Assistant Team (FACAT) to support...

  15. Aging Action: A Course in Senior Advocacy in Kansas.

    Science.gov (United States)

    Kansas State Advisory Council on Aging, Topeka.

    Skills useful in advocacy of senior citizens' needs are discussed in this manual. The topics included are: (1) the meaning of advocacy; (2) assertiveness training for aging-action; (3) identifying issues; (4) choosing issues; (5) developing a plan of action; (6) organizing; (7) legislative advocacy; (8) criteria to evaluate potential legislative…

  16. Small wins matter in advocacy movements: giving voice to patients.

    Science.gov (United States)

    Jason, Leonard A

    2012-06-01

    In this article, the various players are delineated in a story of a contested illness and patient advocacy, played out within the corridors of federal power. It is suggested that the mistreatment and negative attitudes that health care providers and others have towards those with chronic fatigue syndrome (CFS) is possibly due to the social construction of this illness as being a "Yuppie flu" disease. Institutional factors are identified that created these norms and attributions, as well as the multiple stakeholders and constituent groups invested in exerting pressure on policy makers to effect systemic change. This article also provides examples of how the field of Community Psychology, which is fundamentally committed to/based on listening to and giving voice to patients, is broadly relevant to patient activism communities. This approach focused, over time, on epidemiological studies, the name, the case definition, and ultimately the change in CFS leadership at the Centers for Disease Control and Prevention. Keys to this "small wins" approach were coalition building, use of "oppositional experts" (professionals in the scientific community who support patient advocacy goals) to challenge federal research, and taking advantage of developing events/shifts in power. Ultimately, this approach can result in significant scientific and policy gains, and changes in medical and public perception of an illness. PMID:21858612

  17. Effects of a promotor training on local school wellness advocacy capacity.

    Science.gov (United States)

    Jara, Eddy A; Ritterman Weintraub, Miranda; Clifton-Hawkins, Nancy; Martinez, Nestor

    2014-01-01

    There is gap between the enactment and implementation of local school wellness policies. Building the capacity of promotores to engage parents in strengthening local school wellness policy implementation is an innovative strategy. This evaluation study examines the effects of 6 hours of promotor advocacy training to improve local school wellness policy implementation. Consistent with psychological empowerment theory, the training and the related toolkit were designed to increase promotores' knowledge and self-efficacy to engage parents in advocating for improved local school wellness policy implementation. Pre-post training questionnaires (n = 74), five posttraining participant focus groups, and four staff member focus groups explored changes in promotor and participating organization capacity. Findings show increased participant self-efficacy, knowledge, and attitudes to advocate for improved local school wellness policy implementation. Participating organizations reported intention to continue supporting promotor local school wellness policy advocacy. Findings illuminate strategies to strengthen promotor capacity to engage parents in local school wellness policy advocacy. PMID:23182862

  18. Advocacy Journalism and the Rights of Nigerian Children to Free and Compulsory Education: A Prescriptive Approach

    Directory of Open Access Journals (Sweden)

    Ezekiel S. Asemah

    2013-07-01

    Full Text Available The relevance of advocacy journalism in safeguarding the rights of Nigerian child to free and compulsory education is the thrust of this paper. It highlights the strategic importance of journalists to the smooth functioning and development of the society. The paper adopts the analytical tool in examining the imperatives of advocacy journalism in creating awareness to the non-compliance with the constitutional provisions and the different court orders guaranteeing and protecting the rights of the Nigerian child to free, compulsory and basic education. The Nigerian governments at all levels, policy makers, development agencies, non-governmental and community based organisations, though have made interventions to correct this anomaly, yet their efforts cannot be said to have yielded the desired results. This paper, therefore recommends that journalists who want to create a meaningful change, to adopt advocacy journalism as the single most crucial element to facilitate protection of rights of Nigerian Child to free and compulsory education.

  19. Family advocacy, support and education in children's mental health: results of a national survey.

    Science.gov (United States)

    Hoagwood, Kimberly E; Green, Evelyn; Kelleher, Kelly; Schoenwald, Sonja; Rolls-Reutz, Jennifer; Landsverk, John; Glisson, Charles; Mayberg, Stephen

    2008-03-01

    In conjunction with the national survey of mental health service organizations (Schoenwald et al. this issue), a separate but complementary national survey was conducted of family advocacy, support and education organizations (FASEOs). Directors of FASEOs within the same localities as the mental health agencies responded to a survey and provided information in four areas: (1) structure and funding; (2) factors influencing advocacy decisions about children's mental health; (3) types of services provided by FASEOs and factors perceived as related to improved outcomes; and (4) the types of working relationships between FASEOs and local mental health clinics. Findings from a total of 226 (82% response rate) portray a network of family advocacy, support and education organizations that are strategically poised to effect substantive change and characterized by significant fiscal instability. Results from this survey and implications for delivery of family-based services are provided. PMID:17999176

  20. Science Advocacy in a Shifting Policy Landscape

    Science.gov (United States)

    Bickford, E. E.

    2013-12-01

    In the last 50 years, federal investment in research as a share of total spending has declined from a little more than 10% in 1963 to less than 4% in 2013 (AAAS, 2013). In an era of sequestration and shrinking budgets, more and more scientists are advocating directly to policymakers (and their staff) to gain support for research programs and funding. The best advocates understand the political and policy processes, and anticipate policy shifts that may affect them. While scientists are trained with the technical skills to conduct their science, teach it to others, and market their work in order to win grants and publish papers, the policy advocacy arena is unfamiliar territory to many. Acquiring yet another area of expertise mid-career can be daunting, but science advocacy need not require another academic degree. Connecting with policymakers is the first step, and then an understanding of each policymaker's issue history and top priorities will inform the sales pitch. Here, I present some experiences on both the pitching and receiving ends of science advocacy from my year in the US Senate as an AGU/AAAS Congressional Science Fellow, and some guidance for meeting with policymakers and successful science advocacy.

  1. Composite Indicators between Analysis and Advocacy

    Science.gov (United States)

    Saltelli, Andrea

    2007-01-01

    We explore to what extent composite indicators, capable of aggregating multi-dimensional processes into simplified, stylised concepts, are up to the task of underpinning the development of data-based narratives for political advocacy. A recent OECD working paper (Nardo et al., 2005, Handbook on constructing composite indicators: methodology and…

  2. Advocacy and political convergence under preference uncertainty

    NARCIS (Netherlands)

    E. Reuben; C. Traxler; F. van Winden

    2015-01-01

    We study the formation of advocacy groups and how they can impact policy outcomes by revealing information about voters׳ preferences to uninformed political candidates. We conduct a laboratory experiment based on a two-candidate spatial electoral competition setting where the policy preferences of v

  3. Be Proactive with Parent Advocacy Groups

    Science.gov (United States)

    Willis, Mariam

    2012-01-01

    This article elaborates on parent advocacy groups, a key component in meeting the needs of gifted children. The case for parent groups couldn't be stronger--or more urgent. According to Nancy Green, Executive Director of the National Association for Gifted Children, "Quality gifted education exists in places where there are strong parent groups."…

  4. A holistic model of advocacy: factors that influence its use.

    Science.gov (United States)

    Kubsch, Sylvia M; Sternard, Marsha J; Hovarter, Rebecca; Matzke, Vicki

    2004-02-01

    Although advocacy is embraced by nursing as an essential component of holistic philosophy, its scope is often limited in practice. In this article, a research study that examined the use of an expanded definition of advocacy is described. A link to the role of advocacy as a complementary therapy and in relation to facilitating the use of complementary therapies by patients is provided. Fifty-two registered nurses completed a researcher developed advocacy research instrument that assessed the use of moral-ethical, legal, political, spiritual, and substitutive advocacy along with various factors thought to influence the use of advocacy including moral development, perceived assertiveness, and perceived job security. An additional 40 RN-BSN students generated case studies of advocacy enacted in practice that were used as examples of the five categories of advocacy and to support the findings of the survey. Results indicated that moral-ethical advocacy was used more often than the other four categories. Moral stage development had a significant effect on substitutive advocacy but assertiveness and job security were not significant factors influencing any category of advocacy. PMID:14744505

  5. A holistic model of advocacy: factors that influence its use.

    Science.gov (United States)

    Kubsch, Sylvia M; Sternard, Marsha J; Hovarter, Rebecca; Matzke, Vicki

    2004-02-01

    Although advocacy is embraced by nursing as an essential component of holistic philosophy, its scope is often limited in practice. In this article, a research study that examined the use of an expanded definition of advocacy is described. A link to the role of advocacy as a complementary therapy and in relation to facilitating the use of complementary therapies by patients is provided. Fifty-two registered nurses completed a researcher developed advocacy research instrument that assessed the use of moral-ethical, legal, political, spiritual, and substitutive advocacy along with various factors thought to influence the use of advocacy including moral development, perceived assertiveness, and perceived job security. An additional 40 RN-BSN students generated case studies of advocacy enacted in practice that were used as examples of the five categories of advocacy and to support the findings of the survey. Results indicated that moral-ethical advocacy was used more often than the other four categories. Moral stage development had a significant effect on substitutive advocacy but assertiveness and job security were not significant factors influencing any category of advocacy.

  6. Independent donor ethical assessment: aiming to standardize donor advocacy.

    Science.gov (United States)

    Choudhury, Devasmita; Jotterand, Fabrice; Casenave, Gerald; Smith-Morris, Carolyn

    2014-06-01

    Living organ donation has become more common across the world. To ensure an informed consent process, given the complex issues involved with organ donation, independent donor advocacy is required. The choice of how donor advocacy is administered is left up to each transplant center. This article presents the experience and process of donor advocacy at University of Texas Southwestern Medical Center administered by a multidisciplinary team consisting of physicians, surgeons, psychologists, medical ethicists and anthropologists, lawyers, a chaplain, a living kidney donor, and a kidney transplant recipient. To ensure that advocacy remains fair and consistent for all donors being considered, the donor advocacy team at University of Texas Southwestern Medical Center developed the Independent Donor Ethical Assessment, a tool that may be useful to others in rendering donor advocacy. In addition, the tool may be modified as circumstances arise to improve donor advocacy and maintain uniformity in decision making. PMID:24919733

  7. Engaging Ethnically Diverse Teens in a Substance Use Prevention Advocacy Program.

    Science.gov (United States)

    Winkleby, Marilyn A.; Feighery, Ellen C.; Altman, David A.; Kole, Sara; Tencati, Elaine

    2001-01-01

    Engaged low-income adolescents in community advocacy efforts to transform their schools and communities to reduce substance use. The intervention involved social cognitive constructs (sense of community, perceived self-efficacy, outcome expectancies, incentive value, policy control, and leadership competence). Though there were no changes in…

  8. Implications of climate change for skin cancer prevention in Australia.

    Science.gov (United States)

    Makin, Jen

    2011-12-01

    It is estimated that nearly 450,000 Australians get skin cancer every year. Ultraviolet (UV) radiation from sunlight has been identified as the cause of more than 95% of skin cancers in Australia. Accordingly, the focus of skin cancer prevention programs is reducing exposure to UV radiation. In Victoria, improvements in sun protection behaviours and reductions in sunburn and melanoma incidence rates among younger people have been observed since the SunSmart program was established in 1988. However, climate change has the potential to undermine these successes. First, surface UVB radiation is dependent on stratospheric total ozone amounts. While signs of impact of international restrictions on the production of ozone-depleting substances have been observed, improvements have not yet returned ozone to pre-1970s levels. Interactions between ozone depletion and climate change may slow the recovery of the ozone layer and compound increases in UV radiation at some latitudes. Before recovery, it is expected that higher levels of UV radiation will continue in most Australian regions, with an associated higher risk of skin cancer. Indeed, recent data show increases in surface UV radiation throughout Australia since the 1970s. Second, mean temperatures in Australia have increased over the past 30 years and are projected to rise further by 2030. Australian data shows that with higher temperatures, adults spend more time outdoors, are less likely to wear covering clothing and more likely to be sunburnt. Hence, rising temperatures can be expected to result in increases in sun exposure, sunburn and correspondingly, skin cancer risk. PMID:22518918

  9. Advocacy for Education in Museums

    Science.gov (United States)

    Franco, Barbara

    2010-01-01

    Museum education finds itself in the midst of significant changes as both the museum and education fields respond to internal and external challenges that require new approaches. Today, museums recognize that the choice is no longer theirs and that they "must" change to adapt to new economic realities. As museums adapt to new economic realities…

  10. Surviving breast cancer: women's experiences with their changed bodies.

    Science.gov (United States)

    Brunet, Jennifer; Sabiston, Catherine M; Burke, Shaunna

    2013-06-01

    In this study, we explored women's experiences with their bodies following treatment for breast cancer. Eleven women who had been treated for the disease (M(time since treatment)=4.45 years) were interviewed. Data were collected and analyzed using interpretative phenomenological analysis (Smith et al., 2009). Four main themes emerged from the data: changing visibly and invisibly; experiencing intense thoughts and emotions; meaning of the body: a vehicle of health, well-being, and social expression; and managing and dealing with physical changes. Overall, the women experienced various physical changes that shaped, mostly in a negative way, their perceptions, thoughts, attitudes, feelings, and beliefs about their bodies. The women described attempts to make positive lifestyle behavior choices (e.g., diet, participate in physical activity), and used other strategies (e.g., wigs, make-up, clothes) to manage their appearances and restore positive body-related experiences. Based on these findings, it is important to be cognizant of women's body image concerns following breast cancer given the poignant and lasting effects they can have on their psychosocial and emotional well-being.

  11. Genomic diversity of colorectal cancer: Changing landscape and emerging targets.

    Science.gov (United States)

    Ahn, Daniel H; Ciombor, Kristen K; Mikhail, Sameh; Bekaii-Saab, Tanios

    2016-07-01

    Improvements in screening and preventive measures have led to an increased detection of early stage colorectal cancers (CRC) where patients undergo treatment with a curative intent. Despite these efforts, a high proportion of patients are diagnosed with advanced stage disease that is associated with poor outcomes, as CRC remains one of the leading causes of cancer-related deaths in the world. The development of next generation sequencing and collaborative multi-institutional efforts to characterize the cancer genome has afforded us with a comprehensive assessment of the genomic makeup present in CRC. This knowledge has translated into understanding the prognostic role of various tumor somatic variants in this disease. Additionally, the awareness of the genomic alterations present in CRC has resulted in an improvement in patient outcomes, largely due to better selection of personalized therapies based on an individual's tumor genomic makeup. The benefit of various treatments is often limited, where recent studies assessing the genomic diversity in CRC have identified the development of secondary tumor somatic variants that likely contribute to acquired treatment resistance. These studies have begun to alter the landscape of treatment for CRC that include investigating novel targeted therapies, assessing the role of immunotherapy and prospective, dynamic assessment of changes in tumor genomic alterations that occur during the treatment of CRC. PMID:27433082

  12. Genomic diversity of colorectal cancer: Changing landscape and emerging targets

    Science.gov (United States)

    Ahn, Daniel H; Ciombor, Kristen K; Mikhail, Sameh; Bekaii-Saab, Tanios

    2016-01-01

    Improvements in screening and preventive measures have led to an increased detection of early stage colorectal cancers (CRC) where patients undergo treatment with a curative intent. Despite these efforts, a high proportion of patients are diagnosed with advanced stage disease that is associated with poor outcomes, as CRC remains one of the leading causes of cancer-related deaths in the world. The development of next generation sequencing and collaborative multi-institutional efforts to characterize the cancer genome has afforded us with a comprehensive assessment of the genomic makeup present in CRC. This knowledge has translated into understanding the prognostic role of various tumor somatic variants in this disease. Additionally, the awareness of the genomic alterations present in CRC has resulted in an improvement in patient outcomes, largely due to better selection of personalized therapies based on an individual’s tumor genomic makeup. The benefit of various treatments is often limited, where recent studies assessing the genomic diversity in CRC have identified the development of secondary tumor somatic variants that likely contribute to acquired treatment resistance. These studies have begun to alter the landscape of treatment for CRC that include investigating novel targeted therapies, assessing the role of immunotherapy and prospective, dynamic assessment of changes in tumor genomic alterations that occur during the treatment of CRC. PMID:27433082

  13. Genomic diversity of colorectal cancer: Changing landscape and emerging targets.

    Science.gov (United States)

    Ahn, Daniel H; Ciombor, Kristen K; Mikhail, Sameh; Bekaii-Saab, Tanios

    2016-07-01

    Improvements in screening and preventive measures have led to an increased detection of early stage colorectal cancers (CRC) where patients undergo treatment with a curative intent. Despite these efforts, a high proportion of patients are diagnosed with advanced stage disease that is associated with poor outcomes, as CRC remains one of the leading causes of cancer-related deaths in the world. The development of next generation sequencing and collaborative multi-institutional efforts to characterize the cancer genome has afforded us with a comprehensive assessment of the genomic makeup present in CRC. This knowledge has translated into understanding the prognostic role of various tumor somatic variants in this disease. Additionally, the awareness of the genomic alterations present in CRC has resulted in an improvement in patient outcomes, largely due to better selection of personalized therapies based on an individual's tumor genomic makeup. The benefit of various treatments is often limited, where recent studies assessing the genomic diversity in CRC have identified the development of secondary tumor somatic variants that likely contribute to acquired treatment resistance. These studies have begun to alter the landscape of treatment for CRC that include investigating novel targeted therapies, assessing the role of immunotherapy and prospective, dynamic assessment of changes in tumor genomic alterations that occur during the treatment of CRC.

  14. How interest group advocacy is shaped by state policy environments

    OpenAIRE

    Marchetti, Kathleen

    2015-01-01

    Group advocacy has achieved major policy successes in the past fifty years, anti-discrimination policies in employment, and the legalization of same-sex marriage to name two. But does this advocacy represent all groups that need it? In new research which surveys over 200 advocacy organizations Kathleen Marchetti looks at why some groups, such as black women and transgender individuals, are missing from some organizations’ policy discussions and representation. She finds that, among other fact...

  15. Developing the environment agency's capacity for policy advocacy

    OpenAIRE

    Douglas, Philip

    2002-01-01

    The overall rationale and aim of the project was to strengthen Environment Agency policy advocacy effectiveness. In addition to this overall aim, the project had two more specific aims: to identify key features to be included in any process for generating and embedding in the organisation broad policy advocacy positions relevant to UK and EU level policy development and to provide an assessment of Environment Agency policy advocacy effectiveness - alongside English Nature in comparative persp...

  16. Information politics, transnational advocacy and education for all

    OpenAIRE

    Magrath, Bronwen

    2015-01-01

    Introduction: Successful advocacy requires research. Advocacy organizations need to gather evidence to show the extent of a particular social problem, the lack of official response to the problem, and solutions that could be fostered from the ground up. The process of gathering information and using it for political advocacy has been termed “information politics” (Keck & Sikkink 1998). In the past two decades, civil society organizations have played an increasingly prominent role in global...

  17. Evaluation of changes in the attitudes and behaviors of relatives of lung cancer patients toward cancer prevention and screening

    Directory of Open Access Journals (Sweden)

    D Koca

    2013-01-01

    Full Text Available Background: Cancer diagnosis affects all the relatives living with the patient; however, whether the behavior of family members changes or not is unknown. To end this we evaluated the relatives of lung cancer patients. Materials and Methods: Forty-one questions were used to collect data from the relatives of lung cancer patients who had been living with them for at least one year, to evaluate changes in their attitudes and behaviors related to cancer prevention. Results: The study included 246 lung cancer patients′ relatives, of them 172 (69.9% were women and 74 (30.1% were men. The median age was 46 years (range: 20-83 years. Patients and their relatives had been living together for an average of 28 years (range: 1-68 years, and 88 (35.7% of the patients′ relatives were their children. We found changes in the attitudes and behaviors toward prevention and screening for cancer in 92 (37.4% of the relatives. Fifty-two (21.1% of them changed their smoking habits, 34 (13.8% altered their eating habits, 25 (10.2% changed their exercise habits, 13 (5.3% visited a doctor due to a suspicion of having cancer, 12 (4.9% changed their lifestyles, seven (2.8% underwent cancer screening tests, three (1.2% started using alternative medicines, and three (1.2% started using vitamins for cancer prevention. Conclusions: Important changes occur in the attitudes and behaviors of patients′ relatives toward cancer prevention and screening after the patients are diagnosed with lung cancer. Being aware of how patients′ relatives react to a family member′s cancer diagnosis may provide healthcare professionals with more incentive to address the relatives′ special needs.

  18. Change of mammographic density predicts the risk of contralateral breast cancer - a case-control study

    OpenAIRE

    Sandberg, Maria EC; Li, Jingmei; Hall, Per; Hartman, Mikael; dos-Santos-Silva, Isabel; Humphreys, Keith; Czene, Kamila

    2013-01-01

    Introduction Mammographic density is a strong risk factor for breast cancer, but it is unknown whether density at first breast cancer diagnosis and changes during follow-up influences risk of non-simultaneous contralateral breast cancer (CBC). Methods We collected mammograms for CBC-patients (cases, N = 211) and unilateral breast cancer patients (controls, N = 211), individually matched on age and calendar period of first breast cancer diagnosis, type of adjuvant therapy and length of follow-...

  19. Changes in apoptosis during the development of colorectal cancer : a systematic review of the literature

    NARCIS (Netherlands)

    Koornstra, JJ; de Jong, S; Hollema, H; de Vries, EGE; Kleibeuker, JH

    2003-01-01

    The development of colorectal cancer is characterised by an accumulation of molecular genetic alterations causing disorders in cell growth, differentiation and apoptosis. Although changes in apoptosis with colorectal cancer development have been studied extensively, a clear consensus of opinion has

  20. 78 FR 22947 - Open Meeting of the Taxpayer Advocacy Panel Taxpayer Assistance Center Improvements Project...

    Science.gov (United States)

    2013-04-17

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Taxpayer Assistance Center.... SUMMARY: An open meeting of the Taxpayer Advocacy Panel Taxpayer Assistance Center Improvements Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas,...

  1. 75 FR 47348 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2010-08-05

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  2. 76 FR 6190 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2011-02-03

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  3. 78 FR 41194 - Open Meeting of the Taxpayer Advocacy Panel Taxpayer Assistance Center Improvements Project...

    Science.gov (United States)

    2013-07-09

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Taxpayer Assistance Center.... SUMMARY: An open meeting of the Taxpayer Advocacy Panel Taxpayer Assistance Center Improvements Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas,...

  4. 76 FR 56879 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2011-09-14

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  5. 76 FR 10941 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2011-02-28

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  6. 78 FR 22947 - Open Meeting of the Taxpayer Advocacy Panel Taxpayer Communications Project Committee

    Science.gov (United States)

    2013-04-17

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Taxpayer Communications Project... meeting of the Taxpayer Advocacy Panel Taxpayer Communications Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas, and suggestions on improving customer...

  7. 75 FR 10864 - Open meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2010-03-09

    ... Internal Revenue Service Open meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  8. 78 FR 41193 - Open Meeting of the Taxpayer Advocacy Panel Taxpayer Communications Project Committee

    Science.gov (United States)

    2013-07-09

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Taxpayer Communications Project... meeting of the Taxpayer Advocacy Panel Taxpayer Communications Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas, and suggestions on improving customer...

  9. 75 FR 4140 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2010-01-26

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  10. 76 FR 32021 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2011-06-02

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  11. 75 FR 55404 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2010-09-10

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  12. 75 FR 7540 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2010-02-19

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  13. 78 FR 64064 - Open Meeting of the Taxpayer Advocacy Panel Taxpayer Assistance Center Improvements Project...

    Science.gov (United States)

    2013-10-25

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Taxpayer Assistance Center.... SUMMARY: An open meeting of the Taxpayer Advocacy Panel Taxpayer Assistance Center Improvements Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas,...

  14. 75 FR 39333 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2010-07-08

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  15. 76 FR 17993 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2011-03-31

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  16. 78 FR 64063 - Open Meeting of the Taxpayer Advocacy Panel Taxpayer Communications Project Committee

    Science.gov (United States)

    2013-10-25

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Taxpayer Communications Project... meeting of the Taxpayer Advocacy Panel Taxpayer Communications Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas, and suggestions on improving customer...

  17. 75 FR 33893 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2010-06-15

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  18. 78 FR 78516 - Open Meeting of the Taxpayer Advocacy Panel Taxpayer Assistance Center Improvements Project...

    Science.gov (United States)

    2013-12-26

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Taxpayer Assistance Center.... SUMMARY: An open meeting of the Taxpayer Advocacy Panel Taxpayer Assistance Center Improvements Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas,...

  19. 76 FR 63717 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2011-10-13

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  20. 76 FR 37196 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2011-06-24

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  1. 75 FR 62629 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2010-10-12

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  2. 78 FR 78517 - Open Meeting of the Taxpayer Advocacy Panel Taxpayer Communications Project Committee

    Science.gov (United States)

    2013-12-26

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Taxpayer Communications Project... meeting of the Taxpayer Advocacy Panel Taxpayer Communications Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas, and suggestions on improving customer...

  3. 76 FR 45005 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2011-07-27

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  4. 76 FR 2194 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2011-01-12

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  5. Protein expression changes in breast cancer and their importance

    Directory of Open Access Journals (Sweden)

    Tuğba Semerci Sevimli

    2013-03-01

    Full Text Available Studies about nucleic acids have increased after thepublication of DNA’s three dimensional structure by Watsonand Crick. Nucleic acids are the heritable moleculeswhich contain codes for proteins. Proteins are the mostimportant elements in molecular world because they arethe basic structural and functional components of a livingorganism. Clarifying the celluler events that involve proteinsare important in many areas for example diagnosisand treatment determination of diseases or developmentof new drugs. Proteome that comes from a combinationof the terms protein and genome, is one of the importantfield in these days. The studies in this area have acceleratedand gained a different place especially with afterthe completion of human genome project. In synthesis ofa protein just only genetic information is not enough. Atthe same time the change or changes of a protein afterthe synthesis, the final version and transporting to finallocalization of it also important. Because having defects inmailing cells of breast cancer, the first targets of treatmentmust be proteins. In this way the studies on proteins areimportant to determine prognostic and diagnostic diseasemarkers and also significant for identifying new treatmentstrategies.Key words: Genom, proteom, breast cancer

  6. [Early detection of cervical cancer in Chile: time for change].

    Science.gov (United States)

    Léniz Martelli, Javiera; Van De Wyngard, Vanessa; Lagos, Marcela; Barriga, María Isabel; Puschel Illanes, Klaus; Ferreccio Readi, Catterina

    2014-08-01

    Mortality rates for cervical cancer (CC) in Chile are higher than those of developed countries and it has an unequal socioeconomic distribution. The recognition of human papilloma virus (HPV) as the causal agent of cervical cancer in the early 80's changed the prevention paradigms. Current goals are to prevent HPV infection by vaccination before the onset of sexual activity and to detect HPV infection in women older than 30 years. This article reviews CC prevention and early detection methods, discusses relevant evidence to support a change in Chile and presents an innovation proposal. A strategy of primary screening based on HPV detection followed by triage of HPV-positive women by colposcopy in primary care or by cytological or molecular reflex testing is proposed. Due to the existence in Chile of a well-organized nationwide CC prevention program, the replacement of a low-sensitivity screening test such as the Papanicolau test with a highly sensitive one such as HPV detection, could quickly improve the effectiveness of the program. The program also has a network of personnel qualified to conduct naked-eye inspections of the cervix, who could easily be trained to perform triage colposcopy. The incorporation of new prevention strategies could reduce the deaths of Chilean women and correct inequities.

  7. Advocacy--answering old mail. Canadian Association of General Surgeons.

    Science.gov (United States)

    Keith, R G

    1999-06-01

    Since its inception in 1977, the Canadian Association of General Surgeons (CAGS) has struggled with its responsibility to represent general surgeons in practices across this country. The CAGS has tended to be mute in the presentation of many of its accomplishments, which have improved the role of specialists in community practice, training programs and the subspecialties of general surgery. With the forthcoming changes in direction for the Royal College of Physicians and Surgeons of Canada, based on a recent external survey, the CAGS has a golden opportunity to advocate for a clear identity, autonomous from the Royal College for the purposes of scientific meetings, continuing professional development, scientific and practice affiliation with other surgical specialty societies, and new developments with corporate sector support for advancements in science technology and education. Advocacy for general surgery must be stressed as the priority for the CAGS into the future.

  8. Disease Advocacy Organizations Catalyze Translational Research

    Directory of Open Access Journals (Sweden)

    Sharon Fontaine Terry

    2013-06-01

    Full Text Available Disease advocacy organizations have long played an important role in the continuum from basic science to therapy development in rare disease research. PXE International has sometimes led the field in innovative ways, venturing into specific activities that have traditionally been conducted by scientists. As lay founders, we have engaged in gene discovery, gene patenting, diagnostic development, epidemiological studies, clinical trials and therapy research and development. This article will describe the steps that we took, and the ways in which we have scaled these efforts for the larger community.

  9. Nursing advocacy for women veterans and suicide.

    Science.gov (United States)

    Conard, Patricia L; Armstrong, Myrna L; Young, Cathy; Hogan, La Micha

    2015-03-01

    Little is known about suicide variables in women Veterans. The authors reviewed numerous applicable health care and military literary sources regarding suicide in this population. The current article describes the surrounding circumstances, military war/conflict culture, and potential effects on women Veterans, including major collection problems with current Veteran data. Women Veterans are increasingly reporting more behavioral health issues (e.g., posttraumatic stress disorder) and attempting suicide upon civilian reintegration. Outcomes from this literature review suggest the importance of nursing advocacy to create better rapport and communication with women Veterans from Vietnam, Gulf I, Iraq, and Afghanistan wars seeking care at civilian health facilities, as some may present with suicidal ideologies.

  10. Changes of TIZ expression in epithelial ovarian cancer cells

    Institute of Scientific and Technical Information of China (English)

    Huan-Yu Zheng; Hong-Yu Zheng; Yun-Tao Zhou; En-Ling Liu; Jie Li; Yan-Mei Zhang

    2015-01-01

    Objective:To study the change ofTIZ expression in epithelial ovarian cancer cells.Methods:HO8910 cells were transinfected with siRNA to inhibit the expression ofTIZ. pcDNA3.1-TIZ vectors were combined to increase theTIZ expression level.The cell viability, colony forming efficiency and cycle distribution ofHO8910,HO8910/NC,HO8910/pcDNA3.1-NC,HO8910/TIZ-573 andHO8910/pcDNA3.1-TIZ were compared, and the invasion rate, migration rate and adhesion rate between5 groups of cells were compared.Results:Compared with those ofHO8910,HO8910/NC andHO8910/pcDNA3.1-NC, the cell viability, colony forming efficiency and cell cycle distribution ofHO8910/TIZ-573 were increased, while the indexes ofHO8910/pcDNA3.1-NC were decreased with statistical significant difference(P0.05). Conclusions:The expression ofTIZ can inhibit the proliferation of epithelial ovarian cancer cells.

  11. A Media Advocacy Intervention Linking Health Disparities and Food Insecurity

    Science.gov (United States)

    Rock, Melanie J.; McIntyre, Lynn; Persaud, Steven A.; Thomas, Karen L.

    2011-01-01

    Media advocacy is a well-established strategy for transmitting health messages to the public. This paper discusses a media advocacy intervention that raised issues about how the public interprets messages about the negative effects of poverty on population health. In conjunction with the publication of a manuscript illustrating how income-related…

  12. Using Week of the Young Child as an Advocacy Event

    Science.gov (United States)

    Young Children, 2009

    2009-01-01

    The Week of the Young Child 2009, April 19-25, presents a public policy advocacy opportunity for early childhood programs, faculty, and families. This article offers some ways one can use Week of the Young Child (WOYC) events specifically to further advocacy efforts.

  13. Using the Decision Case Method to Teach Legislative Policy Advocacy

    Science.gov (United States)

    Wolfer, Terry A.; Gray, Karen A.

    2007-01-01

    Social work educators have long struggled with making policy practice real "more", especially to micro-oriented students (Sundet & Kelly, 2002). The decision case method can generate excitement about social policy advocacy while educating students about current advocacy work, particularly if the case involves state or local efforts to influence…

  14. School Counselors United in Professional Advocacy: A Systems Model

    Science.gov (United States)

    Cigrand, Dawnette L.; Havlik, Stacey Gaenzle; Malott, Krista M.; Jones, SaDohl Goldsmith

    2015-01-01

    Limited budgets may place educational positions in jeopardy and if school counseling positions become jeopardized, then school counselors must communicate their role and impact more effectively. However, school counselors may lack training and experience in professional self-advocacy practices, and advocacy efforts may be undermined by role…

  15. Speaking up about Advocacy: Findings from a Partnership Research Project

    Science.gov (United States)

    Chapman, Melanie; Bannister, Susan; Davies, Julie; Fleming, Simon; Graham, Claire; Mcmaster, Andrea; Seddon, Angela; Wheldon, Anita; Whittell, Bridget

    2012-01-01

    This article describes a partnership research project carried out by a research team consisting of people with learning disabilities and people without learning disabilities. The research explored people's understandings of advocacy and identified gaps in advocacy provision for people with learning disabilities and their families. Four focus…

  16. Change of SPARC expression after chemotherapy in gastric cancer

    International Nuclear Information System (INIS)

    The expression of tumor biomarkers may change after chemotherapy. However, whether secreted protein acidic and rich in cysteine (SPARC) expression changes after chemotherapy in gastric cancer (GC) is unclear. This study investigated the influence of chemotherapy on SPARC expression in GC. Immunohistochemistry was used to analyze SPARC expression in 132 GC cases (including 54 cases with preoperative chemotherapy and 78 cases without preoperative chemotherapy). SPARC expression of postoperative specimens with and without preoperative chemotherapy was assessed to analyze the influence of chemotherapy on SPARC expression. SPARC was highly expressed in GC compared with the desmoplastic stroma surrounding tumor cells and noncancerous tissues. High SPARC expression was correlated with invasion depth, lymph node, and TNM stage. After chemotherapy, a lower proportion of high SPARC expression was observed in patients with preoperative chemotherapy than in the controls. For 54 patients with preoperative chemotherapy, gross type, histology, depth of invasion, lymph node, TNM stage, and SPARC expression were related to overall survival. Further multivariate analysis showed that lymph node, histology, and SPARC expression after chemotherapy were independent prognostic factors. SPARC expression may change after chemotherapy in GC. SPARC expression should be reassessed for patients with GC after chemotherapy

  17. Change of SPARC expression after chemotherapy in gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Yong-Yin Gao; Xin-Yuan Zhang; Yi Ba; Ding-Zhi Huang; Ru-Bing Han; Xia Wang; Shao-Hua Ge; Hong-Li Li; Ting Deng; Rui Liu; Ming Bai; Li-Kun Zhou

    2015-01-01

    Objective:The expression of tumor biomarkers may change after chemotherapy. However, whether secreted protein acidic and rich in cysteine (SPARC) expression changes atfer chemotherapy in gastric cancer (GC) is unclear. hTis study investigated the inlfuence of chemotherapy on SPARC expression in GC. Methods:Immunohistochemistry was used to analyze SPARC expression in 132 GC cases (including 54 cases with preoperative chemotherapy and 78 cases without preoperative chemotherapy). SPARC expression of postoperative specimens with and without preoperative chemotherapy was assessed to analyze the inlfuence of chemotherapy on SPARC expression. Results:SPARC was highly expressed in GC compared with the desmoplastic stroma surrounding tumor cells and noncancerous tissues. High SPARC expression was correlated with invasion depth, lymph node, and TNM stage. After chemotherapy, a lower proportion of high SPARC expression was observed in patients with preoperative chemotherapy than in the controls. For 54 patients with preoperative chemotherapy, gross type, histology, depth of invasion, lymph node, TNM stage, and SPARC expression were related to overall survival. Further multivariate analysis showed that lymph node, histology, and SPARC expression atfer chemotherapy were independent prognostic factors. Conclusion:SPARC expression may change after chemotherapy in GC. SPARC expression should be reassessed for patients with GC atfer chemotherapy.

  18. Credibility and advocacy in conservation science.

    Science.gov (United States)

    Horton, Cristi C; Peterson, Tarla Rai; Banerjee, Paulami; Peterson, Markus J

    2016-02-01

    Conservation policy sits at the nexus of natural science and politics. On the one hand, conservation scientists strive to maintain scientific credibility by emphasizing that their research findings are the result of disinterested observations of reality. On the other hand, conservation scientists are committed to conservation even if they do not advocate a particular policy. The professional conservation literature offers guidance on negotiating the relationship between scientific objectivity and political advocacy without damaging conservation science's credibility. The value of this guidance, however, may be restricted by limited recognition of credibility's multidimensionality and emergent nature: it emerges through perceptions of expertise, goodwill, and trustworthiness. We used content analysis of the literature to determine how credibility is framed in conservation science as it relates to apparent contradictions between science and advocacy. Credibility typically was framed as a static entity lacking dimensionality. Authors identified expertise or trustworthiness as important, but rarely mentioned goodwill. They usually did not identify expertise, goodwill, or trustworthiness as dimensions of credibility or recognize interactions among these 3 dimensions of credibility. This oversimplification may limit the ability of conservation scientists to contribute to biodiversity conservation. Accounting for the emergent quality and multidimensionality of credibility should enable conservation scientists to advance biodiversity conservation more effectively.

  19. 3 Lifestyle Changes to Help Prevent Breast Cancer

    Science.gov (United States)

    ... many other cancers and chronic disease," said Alice Bender, head of nutrition programs at AICR. The first ... obesity increases the risk of 10 other cancers, Bender said in an institute news release. The second ...

  20. Changes in mammographic density and breast cancer risk

    NARCIS (Netherlands)

    Lokate, A.J.M.

    2012-01-01

    Breast cancer is the most frequently occurring cancer among women worldwide. One of the most important risk factors for breast cancer is high mammographic density. Mammographic density represents the amount of fibroglandular tissue relative to the fat tissue in the breast. Women with >75% of their b

  1. Can exercise change the stereotypes associated with individuals with cancer?

    Science.gov (United States)

    Clément-Guillotin, C; Falzon, C; d'Arripe-Longueville, F

    2015-08-01

    The purpose of this study was to examine whether exercising can positively influence the stereotypes associated with individuals with cancer and, more specifically, have an effect on the impression formation related to warmth and competence. A total of 193 French college students (Mage  = 21.08, SD = 1.44 years; 88 females and 105 males) were randomly assigned to one of the conditions of a 2 (participant sex) × 2 (target health status: cancer vs no information) × 3 (target exercise status: exerciser vs non-exerciser vs no information) experimental design. Results indicated that exercising target with cancer was perceived as the most competent compared with targets with cancer and those without information about cancer. These results suggest that exercising could be an effective way to undermine cancer stereotypes and reduce discrimination against people with cancer.

  2. Can exercise change the stereotypes associated with individuals with cancer?

    Science.gov (United States)

    Clément-Guillotin, C; Falzon, C; d'Arripe-Longueville, F

    2015-08-01

    The purpose of this study was to examine whether exercising can positively influence the stereotypes associated with individuals with cancer and, more specifically, have an effect on the impression formation related to warmth and competence. A total of 193 French college students (Mage  = 21.08, SD = 1.44 years; 88 females and 105 males) were randomly assigned to one of the conditions of a 2 (participant sex) × 2 (target health status: cancer vs no information) × 3 (target exercise status: exerciser vs non-exerciser vs no information) experimental design. Results indicated that exercising target with cancer was perceived as the most competent compared with targets with cancer and those without information about cancer. These results suggest that exercising could be an effective way to undermine cancer stereotypes and reduce discrimination against people with cancer. PMID:24979050

  3. 42 CFR 51.31 - Conduct of protection and advocacy activities.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Conduct of protection and advocacy activities. 51... REQUIREMENTS APPLICABLE TO THE PROTECTION AND ADVOCACY FOR INDIVIDUALS WITH MENTAL ILLNESS PROGRAM Protection and Advocacy Services § 51.31 Conduct of protection and advocacy activities. (a) Consistent with...

  4. 45 CFR 1386.23 - Periodic reports: Protection and Advocacy System.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Periodic reports: Protection and Advocacy System... Advocacy of the Rights of Individuals with Developmental Disabilities § 1386.23 Periodic reports: Protection and Advocacy System. (a) By January 1 of each year the Protection and Advocacy System shall...

  5. 77 FR 8327 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2012-02-14

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Wednesday, March 28, 2012, 2:00 p.m. Eastern Time...

  6. 78 FR 56269 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2013-09-12

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Wednesday, October 23, 2013 at 2:00 p.m. Eastern Time...

  7. 78 FR 11277 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2013-02-15

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Wednesday, March 27, 2013 at 2:00 p.m. Eastern Time...

  8. 77 FR 20488 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2012-04-04

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Wednesday, April 25, 2012, 2 p.m. Eastern Time...

  9. 78 FR 48231 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2013-08-07

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Wednesday, September 25, 2013 at 2:00 p.m. Eastern Time...

  10. 75 FR 62631 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2010-10-12

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint ] Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public... Advocacy Panel Joint Committee will be held Tuesday, November 23, 2010, at 3 p.m. Eastern Time...

  11. 75 FR 33894 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2010-06-15

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comment...) that an open meeting of the Taxpayer Advocacy Panel Joint Committee will be held Thursday, July 8,...

  12. 77 FR 55526 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2012-09-10

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Wednesday, October 24, 2012, 2:00 p.m. Eastern Time...

  13. 78 FR 64063 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2013-10-25

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Wednesday, November 27, 2013 at 2:00 p.m. Eastern Time...

  14. 78 FR 3500 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2013-01-16

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Wednesday, February 27, 2013 at 2:00 p.m. Eastern Time...

  15. 76 FR 56880 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2011-09-14

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Thursday, October 27, 2011, 2 p.m. Eastern Time...

  16. 77 FR 67736 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2012-11-13

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Thursday, December 13, 2012, 2:00 p.m. Eastern Time...

  17. 77 FR 47166 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2012-08-07

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Wednesday, September 26, 2012, 2:00 p.m. Eastern Time...

  18. 75 FR 4141 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2010-01-26

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comment... Advocacy Panel Joint Committee will be held Tuesday, February 23, 2010, at 3 p.m. Eastern Time...

  19. 75 FR 18957 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Issue Committee

    Science.gov (United States)

    2010-04-13

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Issue Committee AGENCY... Taxpayer Advocacy Panel Notice Improvement Issue Committee will be conducted. The Taxpayer Advocacy Panel....C. App. (1988) that an open meeting of the Taxpayer Advocacy Panel Notice Improvement...

  20. 78 FR 41194 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2013-07-09

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Taxpayer Advocacy Panel Joint Committee will be held Tuesday, August 6 from 8:00 a.m. to 4:30 p.m....

  1. 77 FR 40410 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2012-07-09

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Wednesday, August 22, 2012, 2:00 p.m. Eastern Time...

  2. 75 FR 47347 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2010-08-05

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint ] Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public... Advocacy Panel Joint Committee will be held Tuesday, September 28, 2010, at 3 p.m. Eastern Time...

  3. 75 FR 18958 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2010-04-13

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comment... Federal Advisory Committee Act, 5 U.S.C. App. (1988) that an open meeting of the Taxpayer Advocacy...

  4. 77 FR 74921 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2012-12-18

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Wednesday, January 23, 2013 at 2:00 p.m. Eastern Time...

  5. 76 FR 63717 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2011-10-13

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Wednesday, November 23, 2011, 2 p.m. Eastern Time...

  6. 77 FR 5313 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2012-02-02

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Wednesday, February 22, 2012, 2 p.m., Eastern Time...

  7. 78 FR 15126 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2013-03-08

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Wednesday, April 24, 2013 at 2:00 p.m. Eastern Time...

  8. 76 FR 37197 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2011-06-24

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Thursday, August 25, 2011, 2 p.m. Eastern Time...

  9. 75 FR 55407 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2010-09-10

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comment... Advocacy Panel Joint Committee will be held Tuesday, October 26, 2010, at 3 p.m. Eastern Time via...

  10. 77 FR 37102 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2012-06-20

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting ] public... meeting of the Taxpayer Advocacy Panel Joint Committee will be held Thursday, July 19, 2012, at 8 a.m....

  11. 75 FR 76522 - Open meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2010-12-08

    ... Internal Revenue Service Open meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comment... Advocacy Panel Joint Committee will be held Tuesday, January 25, 2011, at 3 p.m. Eastern Time via...

  12. 76 FR 32021 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2011-06-02

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments...) that an open meeting of the Taxpayer Advocacy Panel Joint Committee will be held Monday, July 25,...

  13. 76 FR 2193 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2011-01-12

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comment... Advocacy Panel Joint Committee will be held Monday, February 24, 2011, at 2 p.m. Eastern Time via...

  14. 77 FR 61054 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2012-10-05

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Wednesday, November 28, 2012, 2:00 p.m. Eastern Time...

  15. 76 FR 45006 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2011-07-27

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... Advocacy Panel Joint Committee will be held Thursday, September 22, 2011, 2 p.m. Eastern Time...

  16. Advocacy for Art Education: Beyond Tee-Shirts and Bumper Stickers

    Science.gov (United States)

    Bobick, Bryna; DiCindio, Carissa

    2012-01-01

    Advocacy is not new to art education. Over the years, Goldfarb (1979), Hodsoll (1985), and Erickson and Young (1996) have written about the importance of arts advocacy, but the concept of advocacy has evolved with the times. For example, in the 1970s, arts advocacy was described as a "movement" and brought together art educators, administrators,…

  17. 75 FR 40033 - Proposed Collection; Comment Request for Taxpayer Advocacy Panel (TAP) Tax Check Waiver

    Science.gov (United States)

    2010-07-13

    ... Internal Revenue Service Proposed Collection; Comment Request for Taxpayer Advocacy Panel (TAP) Tax Check...(c)(2)(A)). Currently, the IRS is soliciting comments concerning Taxpayer Advocacy Panel (TAP) Tax...: Taxpayer Advocacy Panel (TAP) Tax Check Waiver. OMB Number: 1545-2092. Abstract: Taxpayer Advocacy...

  18. Cancer core modules identification through genomic and transcriptomic changes correlation detection at network level

    Directory of Open Access Journals (Sweden)

    Li Wenting

    2012-06-01

    Full Text Available Abstract Background Identification of driver mutations among numerous genomic alternations remains a critical challenge to the elucidation of the underlying mechanisms of cancer. Because driver mutations by definition are associated with a greater number of cancer phenotypes compared to other mutations, we hypothesized that driver mutations could more easily be identified once the genotype-phenotype correlations are detected across tumor samples. Results In this study, we describe a novel network analysis to identify the driver mutation through integrating both cancer genomes and transcriptomes. Our method successfully identified a significant genotype-phenotype change correlation in all six solid tumor types and revealed core modules that contain both significantly enriched somatic mutations and aberrant expression changes specific to tumor development. Moreover, we found that the majority of these core modules contained well known cancer driver mutations, and that their mutated genes tended to occur at hub genes with central regulatory roles. In these mutated genes, the majority were cancer-type specific and exhibited a closer relationship within the same cancer type rather than across cancer types. The remaining mutated genes that exist in multiple cancer types led to two cancer type clusters, one cluster consisted of three neural derived or related cancer types, and the other cluster consisted of two adenoma cancer types. Conclusions Our approach can successfully identify the candidate drivers from the core modules. Comprehensive network analysis on the core modules potentially provides critical insights into convergent cancer development in different organs.

  19. Minority Women and Advocacy for Women's Health

    Science.gov (United States)

    Kumanyika, Shiriki K.; Morssink, Christiaan B.; Nestle, Marion

    2001-01-01

    US minority health issues involve racial/ethnic disparities that affect both women and men. However, women's health advocacy in the United States does not consistently address problems specific to minority women. The underlying evolution and political strength of the women's health and minority health movements differ profoundly. Women of color comprise only one quarter of women's health movement constituents and are, on average, socioeconomically disadvantaged. Potential alliances may be inhibited by vestiges of historical racial and social divisions that detract from feelings of commonality and mutual support. Nevertheless, insufficient attention to minority women's issues undermines the legitimacy of the women's health movement and may prevent important advances that can be achieved only when diversity is fully considered. PMID:11527764

  20. Advocacy is Only a Phone Call Away: Strategies to Make a Difference on Behalf of Children and Their Families

    Science.gov (United States)

    LaRocco, Diana; Bruns, Deborah

    2005-01-01

    Because of the pressing needs of young children, families, and communities, public policy advocacy efforts and civic engagement have never been more important. Practitioners in early childhood special education (ECSE) are in a unique position to encourage change on behalf of young children and their families. There are a number of ways in which…

  1. Changing Trends of Breast Cancer Survival in Sultanate of Oman

    OpenAIRE

    Shiyam Kumar; Burney, Ikram A; Adel Al-Ajmi; Al-Moundhri, Mansour S

    2011-01-01

    Breast cancer is the leading cause of cancer-associated mortality in women, with elevated incidence in developing countries. This retrospective study included all 122 patients diagnosed with breast cancer from January 2003 to December 2008 in the Sultanate of Oman. Age at presentation was 47.41 years (SD ± 12.88), with one-third of patients younger than 40 years. The majority of patients presented with stage III (41.2%) and IV (18.2%) breast cancer. T size ( = . 0 2 3 ), skin involvement ( ...

  2. THE ROLE OF PERSONAL BRAND IN THE ADVOCACY ACTIVITY,IN ROMANIA

    Directory of Open Access Journals (Sweden)

    Corina Anamaria IOAN

    2014-04-01

    Full Text Available The advocacy activity is of significant importance for the business community, the perception of its need to influence the legislative process in order to have a transparent legislative procedure, the necessity of understanding the way in which the decisions are taken and the desire of the business community to assist the changing of laws and norms being linking elements of the advocacy activity to the business environment. The branding impact is practically immeasurable in social and cultural terms as it over exceeded the commercial origins. It has spread in education, sports, fashion, tourism, arts, theater, literature, regional and national politics and in almost all other fields that we could think of. The non-profit and charitable organizations that compete with the commercial brands in the emotional territory of the minds and hearts of people, for the money in their pockets, use branding more and more.

  3. Pediatric behavior guidance in the 21st century workshop C report - advocacy and policy.

    Science.gov (United States)

    Quinonez, Rocio B; Nelson, Travis

    2014-01-01

    This report outlines a series of recommendations derived from an advocacy and policy workshop at the 2013 American Academy of Pediatric Dentistry (AAPD) Behavior Guidance Symposium. The committee charge was to address two questions: (1) what should be done to change public and media perception of behavior guidance, if anything, and: (2) what should be done to insure that needed behavior guidance techniques will be available for practicing pediatric dentists in the future. Members of the workshop voiced a wide variety of opinions and impressions of how public perception and media promotion of behavior guidance affect the practice of pediatric dentistry. A diverse assortment of strategies to promote the availability of these techniques in the future was suggested. This report will serve to inform policy and advocacy efforts by AAPD to improve children's oral health and promote excellence in patient care.

  4. Changes in sexual function after radiotherapy treatment of prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Beckendorf, V. [Centre Alexis Vautrin, Vandoeuvre-les Nancy (France); Hay, M. [Centre Val d`Aurelle, Montpellier (France); Rozan, R. [Centre Jean Perrin, Clermont-Ferrand (France); Lagrange, J.L. [Centre Antoine Lacassagne, Nice (France); N`Guyen, T. [Centre Jean Godinot, Reims (France); Giraud, B. [CCMI Commission de Cooperation Medicale Intercentres, Centre Hospitalier Univ. et Centre Jean Perrin, Clement-Ferrand (France)

    1996-01-01

    The objective was to assess sexual function before and after definitive irradiation for the treatment of cancer of the prostate. The study comprised 67 patients (mean age 68 years) treated in five radiotherapy departments and assessed with repeated questionnaires about their libido, arousal, frequency and quality of intercourse, and sexual satisfaction. Interviews were obtained before radiotherapy and at the end of the first year after treatment. Sixty-three patients were married and 50 had a sexually effective partner. Forty-six patients presented with another pathology or medical treatment capable of inducing sexual dysfunction. Before radiotherapy, 40 patients were sexually active, with good to acceptable intercourse. Between 10 and 24 months after the end of radiotherapy, no disease progression was observed and prostate-specific antigen levels remained high in only two patients. Sexual function was preserved in 67% of patients but only 50% observed no change. The functional prognosis seemed to be related to the initial frequency and quality of intercourse; more than three times per month, the prognosis remained good, under three per month, it was poor. The patient`s age was a predictive factor for the frequency of intercourse. (author).

  5. Community-based advocacy opportunities for tobacco control: experience from Tanzania.

    Science.gov (United States)

    Kagaruki, Lutgard K

    2010-06-01

    Tanzania is third in Africa in tobacco production after Malawi and Zimbabwe. In spite of increased production, Tanzania remains a poor country, with tobacco farmers getting poorer and the country losing more than 16,500 hectares of forests annually from tobacco curing alone. Tanzania grows fire-cured and air-cured tobacco. Regarding tobacco use, 35% of Tanzanians smoke tobacco regularly and about 32% of all cancers at Ocean Road Cancer Institute are attributed to tobacco use, with the country spending more than $30m annually to treat tobacco-related cancers. Unfortunately, knowledge on tobacco-related hazards is limited even among policy/decision makers. However, surveys indicate that more than 65% of resource-poor tobacco farmers favour alternative livelihoods when assured of sustainable markets. There is need of intensifying advocacy campaigns against tobacco, in order to improve the socio-economic status of tobacco farmers, enhance public health and sustain the environment in Tanzania.

  6. NGO Advocacy on Women's Health and Rights in Southeast Asia

    OpenAIRE

    Rashidah Abdullah

    2003-01-01

    Rashidah Abdullah highlights strategies used in advocacy work by women NGOs in the Southeast Asia region based on the work of ARROW. Development (2003) 46, 33–37. doi:10.1057/palgrave.development.1110442

  7. Handicapped Infants and Euthanasia: A Challenge to Our Advocacy.

    Science.gov (United States)

    Smith, J. David

    1985-01-01

    The issue of pediatric euthanasia for handicapped newborns is examined and contrasting viewpoints emphasizing the quality and the sanctity of life are considered. The author asserts that advocacy for handicapped children involves decisions regarding the euthanasia question. (CL)

  8. Research methods to change clinical practice for patients with rare cancers.

    Science.gov (United States)

    Billingham, Lucinda; Malottki, Kinga; Steven, Neil

    2016-02-01

    Rare cancers are a growing group as a result of reclassification of common cancers by molecular markers. There is therefore an increasing need to identify methods to assess interventions that are sufficiently robust to potentially affect clinical practice in this setting. Methods advocated for clinical trials in rare diseases are not necessarily applicable in rare cancers. This Series paper describes research methods that are relevant for rare cancers in relation to the range of incidence levels. Strategies that maximise recruitment, minimise sample size, or maximise the usefulness of the evidence could enable the application of conventional clinical trial design to rare cancer populations. Alternative designs that address specific challenges for rare cancers with the aim of potentially changing clinical practice include Bayesian designs, uncontrolled n-of-1 trials, and umbrella and basket trials. Pragmatic solutions must be sought to enable some level of evidence-based health care for patients with rare cancers.

  9. Inflammatory breast cancer: unique biological and therapeutic considerations.

    Science.gov (United States)

    Woodward, Wendy A

    2015-11-01

    Through the concerted efforts of many patients, health-care providers, legislators, and other supporters, the past decade has seen the development of the first clinics dedicated to the care of patients with inflammatory breast cancer in the USA and other countries. Together with social networking, advocacy, and education, a few specialised centres have had substantial increases in patient numbers (in some cases ten times higher), which has further expanded the community of science and advocacy and increased the understanding of the disease process. Although inflammatory breast cancer is considered rare, constituting only 2-4% of breast cancer cases, poor prognosis means that patients with the disease account for roughly 10% of breast cancer mortality annually in the USA. I propose that the unique presentation of inflammatory breast cancer might require specific, identifiable changes in the breast parenchyma that occur before the tumour-initiating event. This would make the breast tissue itself a tumour-promoting medium that should be treated as a component of the pathology in multidisciplinary treatment and should be further studied for complementary targets to inhibit the pathobiology that is specific to inflammatory breast cancer. PMID:26545845

  10. Assessment of a tool for measuring non-profit advocacy efforts in India, Uganda and Yemen.

    Science.gov (United States)

    Lalwani, Tanya; Rajaratnam, Julie Knoll; McOwen, Jordan; Gordis, Deborah J; Bowen, Lisa A; Bernson, Jeff

    2016-03-01

    To improve maternal and child health, the White Ribbon Alliance for Safe Motherhood (WRA) implemented an innovative policy advocacy project in India, Uganda and Yemen from 2009 to 2011. PATH assisted WRA in designing an approach to measure the short- and long-term results of WRA's advocacy efforts.Expert rating instruments have been widely used since 1970s to track country-level program efforts focusing on family planning, maternal and neonatal health, and HIV/AIDS. This article assesses and establishes the strength and applicability of an expert rating tool, the Maternal Health Policy Score (MHPS), in measuring and guiding a non-profit's advocacy efforts.The tool was assessed using five criteria: validity of results, reproducibility of results, acceptability to respondents, internal consistency and cost. The tool proved effective for measuring improvements in the policy environment at both the national and subnational levels that the non-profit intended to effect and useful for identifying strong and weak policy domains. The results are reproducible, though ensuring fidelity in implementation during different rounds of data collection may be difficult. The acceptability of the tool was high among respondents, and also among users of the information.MHPS provides a quick, low-cost method to measure overall changes in the policy environment, giving advocacy organizations and grant makers timely information to gauge the influence of their work and take corrective action. WRA demonstrated the use of MHPS at multiple points in the project: at the onset of a project to identify and strategize around policy domains that need attention, during and at the end of the project to monitor progress made and redirect efforts. PMID:25149099

  11. Assessment of a tool for measuring non-profit advocacy efforts in India, Uganda and Yemen.

    Science.gov (United States)

    Lalwani, Tanya; Rajaratnam, Julie Knoll; McOwen, Jordan; Gordis, Deborah J; Bowen, Lisa A; Bernson, Jeff

    2016-03-01

    To improve maternal and child health, the White Ribbon Alliance for Safe Motherhood (WRA) implemented an innovative policy advocacy project in India, Uganda and Yemen from 2009 to 2011. PATH assisted WRA in designing an approach to measure the short- and long-term results of WRA's advocacy efforts.Expert rating instruments have been widely used since 1970s to track country-level program efforts focusing on family planning, maternal and neonatal health, and HIV/AIDS. This article assesses and establishes the strength and applicability of an expert rating tool, the Maternal Health Policy Score (MHPS), in measuring and guiding a non-profit's advocacy efforts.The tool was assessed using five criteria: validity of results, reproducibility of results, acceptability to respondents, internal consistency and cost. The tool proved effective for measuring improvements in the policy environment at both the national and subnational levels that the non-profit intended to effect and useful for identifying strong and weak policy domains. The results are reproducible, though ensuring fidelity in implementation during different rounds of data collection may be difficult. The acceptability of the tool was high among respondents, and also among users of the information.MHPS provides a quick, low-cost method to measure overall changes in the policy environment, giving advocacy organizations and grant makers timely information to gauge the influence of their work and take corrective action. WRA demonstrated the use of MHPS at multiple points in the project: at the onset of a project to identify and strategize around policy domains that need attention, during and at the end of the project to monitor progress made and redirect efforts.

  12. Prospective weight change and colon cancer risk in male US health professionals

    DEFF Research Database (Denmark)

    Thygesen, Lau Caspar; Grønbaek, Morten; Johansen, Christoffer;

    2008-01-01

    Epidemiological studies are remarkably consistent, especially among men, in showing that overweight and obesity [body mass index (BMI) >25] are associated with increased risk of colon cancer. However, no prospective studies address the influence of weight change in adulthood on subsequent colon...... cancer risk. In this study, we investigated whether weight change influences colon cancer risk utilizing prospectively collected weight data. We included 46,349 men aged 40-75 participating in the Health Professionals Follow-Up Study. Questionnaires including items on weight were completed every second......-year period, we documented 765 cases of colon cancer. Cumulative mean BMI >22.5 was associated with significantly increased risk of colon cancer. The short-term weight change in the prior 2 to 4 years was positively and significantly associated with risk [HR = 1.14 (95% confidence interval, 1...

  13. The changing epidemiology of smoking and lung cancer histology.

    OpenAIRE

    Wynder, E. L.; Muscat, J E

    1995-01-01

    In 1950, the first large-scale epidemiological studies demonstrated that lung cancer is causatively associated with cigarette smoking, a finding subsequently confirmed by the Royal College of Physicians in London, the U.S. Surgeon General, and the World Health Organization. Although cigarette consumption has gradually decreased in the United States from a high of about 3800 cigarettes per adult per year in 1965 to about 2800 cigarettes in 1993, death from lung cancer has reached a high among ...

  14. The Changing Landscape of Breast Cancer: How Biology Drives Therapy

    Directory of Open Access Journals (Sweden)

    Sarah Friend

    2016-01-01

    Full Text Available Breast cancer is the most prevalent life-threatening cancer in women. Optimizing therapy to increase cure rates in early stage disease, and improving life expectancy and palliation for advanced stages, are goals driving major areas of research. The armamentarium of targeted treatments for breast cancer is ever expanding as understanding of breast cancer biology deepens. A revolution in our treatment was heralded a decade ago by the introduction of trastuzumab for human epidermal receptor-2 positive (HER2+ disease resulting in remarkable reductions in recurrence and improvements in overall survival (OS. Advances continue to be made in other breast cancer subtypes targeting key activating pathways for therapeutic development. However, for these other targeted agents, improvement in OS has been elusive. This article focuses on the development of targeted therapy in breast cancer focusing primarily on the last 5 years, to illustrate that as we understand the complex pathways allowing the dysregulated cell to become malignant, it also propels us closer towards the promise of precision and personalized medicine.

  15. Changing Epidemiology of Common Cancers in Southern Iran, 2007-2010: A Cross Sectional Study.

    Directory of Open Access Journals (Sweden)

    Seyed Masoom Masoompour

    Full Text Available We have evaluated the ever changing epidemiology of cancers in Fars province, Iran since the re-establishment of Fars cancer registry. Based on the collected data from all related sources in Fars province from 2007-2010 we calculated the cancer age-standardized rates per 100,000 person-years (ASRs. The results are presented as incidence rates of cases by site according to the International Classification of Diseases for Oncology (ICD-O, sex, age, crude rate, and ASRs. In women the total ASR was 41.70 per 100,000 from 1985-1989 which had increased to 55.50 and 95.46 during 1998-2002 and 2007-2010. The incidence of breast cancer in women during 2007-2010 was about two and four times higher than 1998-2002 and 1985-1989. The incidence of colorectal cancer in women during 2007-2010 was about three and five times higher than 1998-2002 and 1985-1989. In men the total ASR was 62.9 per 100,000 in 1985-1989 that increased to 64.50 and 101.48 during 1998-2002 and 2007-2010. Although stomach cancer was the most common cancer among men during 1985-1989 and 1998-2002, but in recent study bladder cancer was the most common cancer among men in Fars province. The incidence of colorectal cancer in men during 2007-2010 was about three times higher than 1998-2002 and 1985-1989. This study shows growing incidence of cancer in southern Iran. The colorectal cancer in both genders had increased and its pattern is similar to western countries. In men, bladder and prostate cancers had a growing rate and the incidences of these cancers in the present study were greater than stomach cancer.

  16. Ozone depletion, related UVB changes and increased skin cancer incidence

    Science.gov (United States)

    Kane, R. P.

    1998-03-01

    Stratospheric ozone at middle latitudes shows a seasonal variation of about +/-20%, a quasi-biennial oscillation of 1-10% range and a long-term variation in which the level was almost steady up to about 1979 and declined thereafter to the present day by about 10%. These variations are expected to be reflected in solar UVB observed at the ground, but in an opposite direction. Thus UVB should have had a long-term increase of about 10-20%, which should cause an increase in skin cancer incidence of about 20-40%. Skin cancer incidence has increased all over the world, e.g. about 90% in USA during 1974-1990. It is popularly believed that this increase in skin cancer incidence is related to the recent ozone depletion. This seems to be incorrect, for two reasons. Firstly, the observed skin cancer increase is too large (90%) compared with the expected value (40%) from ozone depletion. Secondly, cancer does not develop immediately after exposure to solar UVB. The sunburns may occur within hours; but cancer development and detection may take years, even decades. Hence the observed skin cancer increase since 1974 (no data available for earlier periods) must have occurred due to exposure to solar UVB in the 1950s and 1960s, when there was no ozone depletion. Thus, the skin cancer increase must be attributed to harmful solar UVB levels existing even in the 1960s, accentuated later not by ozone depletion (which started only much later, by 1979) but by other causes, such as a longer human life span, better screening, increasing tendencies of sunbathing at beaches, etc., in affluent societies. On the other hand, the recent ozone depletion and the associated UVB increases will certainly take their toll; only that the effects will not be noticed now but years or decades from now. The concern for the future expressed in the Montreal Protocol for reducing ozone depletion by controlling CFC production is certainly justified, especially because increased UVB is harmful to animal and

  17. NIH scientists map gene changes driving tumors in common pediatric soft-tissue cancer

    Science.gov (United States)

    Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes. The genetic alterations identified in this malignancy could be useful

  18. The Vicious Worm - a cysticercosis advocacy information tool

    DEFF Research Database (Denmark)

    Saarnak, Christopher; Trevisan, Chiara; Mejer, Helena;

    Porcine cysticercosis is an infection of pigs caused by the larval stage of Taenia solium, a tapeworm that causes taeniosis in humans. The disease is common in developing countries and is a serious public health risk. Cysticercosis implicates significant economic losses, both in pig production an...... practitioners; MD’s in health centres, veterinary and agricultural extension officers and pig traders. Furthermore there will be a policy brief aimed at the key decision makers at ministry level....... cysticercosis must be on health education engaging the communities and creating public awareness. Enhancing basic conditions such as hygiene has an important effect on reducing the risk of transmission. In addition some very simple but effective changes in people’s day-to-day practices such as use of latrines...... Health neglected zoonotic diseases projects, funded by the European Commission through its 7th framework program. Part of University of Copenhagen’s tasks in these projects is to develop an improved advocacy tool for teaching about cysticercosis, including information on how to diagnose and treat...

  19. Changing patterns of colorectal cancer in China over a period of 20 years

    Institute of Scientific and Technical Information of China (English)

    Ming Li; Jin Gu

    2005-01-01

    AIM: To determine whether any changes have occurred on the patterns of colorectal cancer in China.METHODS: Data from 21 Chinese articles published from 1980 to 1999, were used to analyze the time trend of colorectal cancer according to the patients' age at diagnosis,sex, the site of the tumor, stage, and the pathology.RESULTS: From 1980s to 1990s, the mean age of the colorectal cancer patients has increased. The percentage of the female patients rose. The distribution of colorectal carcinoma shows a predominance of rectal cancer. However,the proportion of proximal colon cancer (including transverse and ascending colon) increased significantly accompanied by a decline in the percentage of rectal cancer. Similarity in the percentage of distal colon cancer between two decades was revealed. In the 1990s, statistically more Stage B patients were found than those in 1980s. In addition, databases show a significant decrease in the Stage D cases. The proportion of adenocarcinoma increased, but the mucinous adenocarcinoma decreased during two decades.CONCLUSION: These findings indicate that the patternof colorectal cancer in China has been changing. Especially,a proximal shift due to the increasing proportion of ascending and transverse colon cancer has occurred in China.

  20. Body composition changes in females treated for breast cancer: a review of the evidence

    OpenAIRE

    Sheean, Patricia M.; Hoskins, Kent; Stolley, Melinda

    2012-01-01

    Body composition changes cannot be precisely captured using body weight or body mass index measures. Therefore, the primary purpose of this review was to characterize the patterns of body composition change in females treated for breast cancer including only studies that utilize imaging technologies to quantify adipose tissue and lean body mass (LBM). We reviewed PubMed for studies published between 1971–2012 involving females diagnosed with breast cancer where computed axial tomography (CAT)...

  1. Changes in symptoms and pain intensity of cancer patients after enrollment in palliative care at home

    OpenAIRE

    Dumitrescu, Luminita; van den Heuvel-Olaroiu, Marinela; van den Heuvel, Wim J. A.

    2007-01-01

    This study describes the activities and interventions carried out by an at-home palliative care team treating cancer patients who died within two years of being enrolled in a palliative care program. It analyzes which changes in symptoms and pain occurred and which sociodemographic and medical characteristics were related to these changes. The analysis is based on 102 cancer patients. Data were collected through systematic registration during the palliative care process. At enrollment, patien...

  2. Metabolic changes in cancer: beyond the Warburg effect

    Institute of Scientific and Technical Information of China (English)

    Weihua Wu; Shimin Zhao

    2013-01-01

    Altered metabolism is one of the hallmarks of cancer cells.The best-known metabolic abnormality in cancer cells is the Warburg effect,which demonstrates an increased glycolysis even in the presence of oxygen.However,tumor-related metabolic abnormalities are not limited to altered balance between glucose fermentation and oxidative phosphorylation.Key tumor genes such as p53 and c-myc are found to be master regulators of metabolism.Metabolic enzymes such as succinate dehydrogenase,fumarate hydratase,pyruvate kinase,and isocitrate dehydrogenase mutations or expressing level alterations are all linked to tumorigenesis.In this review,we introduce some of the cancer-associated metabolic disorders and current understanding of their molecular tumorigenic mechanisms.

  3. Glycosylation Changes on Serum Glycoproteins in Ovarian Cancer May Contribute to Disease Pathogenesis

    OpenAIRE

    Radka Saldova; Wormald, Mark R.; Dwek, Raymond A.; Rudd, Pauline M

    2008-01-01

    Ovarian cancer is the most lethal of all gynaecological cancers among women. Serum CA125 is the only biomarker that is used routinely and there is a need for further complementary biomarkers both in terms of sensitivity and specificity. N-glycosylation changes in ovarian cancer serum glycoproteins include a decrease in galactosylation of IgG and an increase in sialyl Lewis X (SLex) on haptoglobin β-chain, α1-acid glycoprotein and α1-antichymotrypsin. These changes are also present in chronic ...

  4. Collagen mRNA levels changes during colorectal cancer carcinogenesis

    DEFF Research Database (Denmark)

    Skovbjerg, Hanne; Anthonsen, Dorit; Lothe, Inger M B;

    2009-01-01

    BACKGROUND: Invasive growth of epithelial cancers is a complex multi-step process which involves dissolution of the basement membrane. Type IV collagen is a major component in most basement membranes. Type VII collagen is related to anchoring fibrils and is found primarily in the basement membran...

  5. Patient advocacy from the clinical nurses' viewpoint: a qualitative study.

    Science.gov (United States)

    Davoodvand, Shirmohammad; Abbaszadeh, Abbas; Ahmadi, Fazlollah

    2016-01-01

    One of the advanced nursing care procedures emphasized by nursing organizations around the world is patient or nursing advocacy. In addition to illustrating the professional power of nursing, it helps to provide effective nursing care. The aim of the present study was to explain the concept of patient advocacy from the perspective of Iranian clinical nurses. This was a qualitative study that examined the viewpoint and experiences of 15 clinical nurses regarding patient advocacy in nursing. The nurses worked in intensive care units (ICUs), coronary care units (CCUs), and emergency units. The study participants were selected via purposeful sampling. The data was collected through semi-structured interviews and analyzed using content analysis. Data analysis showed that patient advocacy consisted of the two themes of empathy with the patient (including understanding, being sympathetic with, and feeling close to the patient) and protecting the patients (including patient care, prioritization of patients' health, commitment to the completion of the care process, and protection of patients' rights). The results of this study suggest that nurses must be empathetic toward and protective of their patients. The results of the present study can be used in health care delivery, nursing education, and nursing management and planning systems to help nurses accomplish their important role as patient advocates. It is necessary to further study the connections between patient advocacy and empathy.

  6. Patient advocacy from the clinical nurses' viewpoint: a qualitative study.

    Science.gov (United States)

    Davoodvand, Shirmohammad; Abbaszadeh, Abbas; Ahmadi, Fazlollah

    2016-01-01

    One of the advanced nursing care procedures emphasized by nursing organizations around the world is patient or nursing advocacy. In addition to illustrating the professional power of nursing, it helps to provide effective nursing care. The aim of the present study was to explain the concept of patient advocacy from the perspective of Iranian clinical nurses. This was a qualitative study that examined the viewpoint and experiences of 15 clinical nurses regarding patient advocacy in nursing. The nurses worked in intensive care units (ICUs), coronary care units (CCUs), and emergency units. The study participants were selected via purposeful sampling. The data was collected through semi-structured interviews and analyzed using content analysis. Data analysis showed that patient advocacy consisted of the two themes of empathy with the patient (including understanding, being sympathetic with, and feeling close to the patient) and protecting the patients (including patient care, prioritization of patients' health, commitment to the completion of the care process, and protection of patients' rights). The results of this study suggest that nurses must be empathetic toward and protective of their patients. The results of the present study can be used in health care delivery, nursing education, and nursing management and planning systems to help nurses accomplish their important role as patient advocates. It is necessary to further study the connections between patient advocacy and empathy. PMID:27471588

  7. PET/CT may change diagnosis and treatment in cancer patients

    DEFF Research Database (Denmark)

    Petersen, Henrik; Nielsen, Mie Jung; Høilund-Carlsen, Mette;

    2010-01-01

    diagnosis in 16% and induced a change in staging and treatment plan in 28% to 32% of cases, respectively. CONCLUSION: FDG PET/CT was mainly used for diagnosis in lung cancer and in cases with an unknown primary tumour, and for response evaluation in lymphomas and colorectal cancer. PET/CT caused a change......INTRODUCTION: The national focus on cancer has propelled the use of PET/CT for cancer imaging in Denmark. We believe that first-year experiences from a large PET centre may be of interest to new users. MATERIAL AND METHODS: Data from all scans made in the period from February 28 2006 to March 1...... 2007 with a single PET/CT scanner and 18F-fluoro-deoxyglucose (FDG) were collected prospectively along with information on action diagnosis, study purpose, etc. Referring departments indicated if PET/CT had changed or confirmed diagnosis, staging and treatment plan. RESULTS: A total of 970 scans were...

  8. Evolution of breast cancer management in Ireland: a decade of change.

    LENUS (Irish Health Repository)

    Heneghan, Helen M

    2009-01-01

    BACKGROUND: Over the last decade there has been a paradigm shift in the management of breast cancer, subsequent to revised surgical oncology guidelines and consensus statements which were derived in light of landmark breast cancer clinical trials conducted throughout the latter part of the 20th century. However the sheer impact of this paradigm shift upon all modalities of treatment, and the current trends in management of the disease, are largely unknown. We aimed to assess the changing practices of breast cancer management over the last decade within a specialist tertiary referral Breast Cancer Centre. METHODS: Comparative analysis of all aspects of the management of breast cancer patients, who presented to a tertiary referral Breast Cancer Centre in 1995\\/1996 and 2005\\/2006, was undertaken and measured against The European Society for Surgical Oncology guidelines for the surgical management of mammographically detected lesions [1998]. RESULTS: 613 patients\\' case profiles were analysed. Over the last decade we observed a dramatic increase in incidence of breast cancer [>100%], a move to less invasive diagnostic and surgical therapeutic techniques, as well as increased use of adjuvant therapies. We also witnessed the introduction of immediate breast reconstruction as part of routine practice CONCLUSION: We demonstrate that radical changes have occurred in the management of breast cancer in the last decade, in keeping with international guidelines. It remains incumbent upon us to continue to adapt our practice patterns in light of emerging knowledge and best evidence.

  9. Predicting Levels of Policy Advocacy Engagement Among Acute-Care Health Professionals.

    Science.gov (United States)

    Jansson, Bruce S; Nyamathi, Adeline; Heidemann, Gretchen; Bird, Melissa; Ward, Cathy Rogers; Brown-Saltzman, Katherine; Duan, Lei; Kaplan, Charles

    2016-02-01

    This study aims to describe the factors that predict health professionals' engagement in policy advocacy. The researchers used a cross-sectional research design with a sample of 97 nurses, 94 social workers, and 104 medical residents from eight hospitals in Los Angeles. Bivariate correlations explored whether seven predictor scales were associated with health professionals' policy advocacy engagement and revealed that five of the eight factors were significantly associated with it (p advocacy engagement, eagerness, skills, tangible support, and organizational receptivity. Regression analysis examined whether the seven scales, when controlling for sociodemographic variables and hospital site, predicted levels of policy advocacy engagement. Results revealed that patient advocacy engagement (p advocacy engagement. Ethical commitment did not predict policy advocacy engagement. The model explained 36% of the variance in policy advocacy engagement. Limitations of the study and its implications for future research, practice, and policy are discussed.

  10. 77 FR 37101 - Open Meeting of the Taxpayer Advocacy Panel Bankruptcy Compliance Project Committee

    Science.gov (United States)

    2012-06-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Bankruptcy Compliance Project... meeting of the Taxpayer Advocacy Panel Bankruptcy Compliance Project Committee will be conducted....

  11. 77 FR 55525 - Open Meeting of the Taxpayer Advocacy Panel Bankruptcy Compliance Project Committee

    Science.gov (United States)

    2012-09-10

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF THE TREASURY Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Bankruptcy Compliance Project... meeting of the Taxpayer Advocacy Panel Bankruptcy Compliance Project Committee will be conducted....

  12. 77 FR 2611 - Open Meeting of the Taxpayer Advocacy Panel Bankruptcy Compliance Project Committee

    Science.gov (United States)

    2012-01-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Bankruptcy Compliance Project... meeting of the Taxpayer Advocacy Panel Bankruptcy Compliance Project Committee will be conducted....

  13. 77 FR 47165 - Open Meeting of the Taxpayer Advocacy Panel Bankruptcy Compliance Project Committee

    Science.gov (United States)

    2012-08-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Bankruptcy Compliance Project... meeting of the Taxpayer Advocacy Panel Bankruptcy Compliance Project Committee will be conducted....

  14. Epigenetic changes of DNA repair genes in cancer

    Institute of Scientific and Technical Information of China (English)

    Christoph Lahtz; Gerd P. Pfeifer

    2011-01-01

    'Every Hour Hurts, The Last One Kills'. That is an old saying about getting old. Every day, thousands of DNA damaging events take place in each cell of our body, but efficient DNA repair systems have evolved to prevent that. However, our DNA repair system and that of most other organisms are not as perfect as that of Deinococcus radiodurans, for example, which is able to repair massive amounts of DNA damage at one time. In many instances, accumulation of DNA damage has been linked to cancer, and genetic deficiencies in specific DNA repair genes are associated with tumor-prone phenotypes. In addition to mutations, which can be either inherited or somatically acquired, epigenetic silencing of DNA repair genes may promote tumorigenesis. This review will summarize current knowledge of the epigenetic inactivation of different DNA repair components in human cancer.

  15. Specific changes in the expression of imprinted genes in prostate cancer-implications for cancer progression and epigenetic regulation

    Institute of Scientific and Technical Information of China (English)

    Teodora Ribarska; Klaus-Marius Bastian; Annemarie Koch; Wolfgang A Schulz

    2012-01-01

    Epigenetic dysregulation comprising DNA hypermethylation and hypomethylation,enhancer of zeste homologue 2 (EZH2)overexpression and altered patterns of histone modifications is associated with the progression of prostate cancer.DNA methylation,EZH2 and histone modifications also ensure the parental-specific monoallelic expression of at least 62 imprinted genes.Although it is therefore tempting to speculate that epigenetic dysregulation may extend to imprinted genes,expression changes in cancerous prostates are only well documented for insulin-like growth factor 2 (IGF2).A literature and database survey on imprinted genes in prostate cancer suggests that the expression of most imprinted genes remains unchanged despite global disturbances in epigenetic mechanisms.Instead,selective genetic and epigenetic changes appear to lead to the inactivation of a sub-network of imprinted genes,which might function in the prostate to limit cell growth induced viathe PI3K/Akt pathway,modulate androgen responses and regulate differentiation.Whereas dysregulation of IG F2 may constitute an early change in prostate carcinogenesis,inactivation of this imprinted gene network is rather associated with cancer progression.

  16. Psychometric Properties of the Patient Self-Advocacy Scale: The Persian Version

    Directory of Open Access Journals (Sweden)

    Shaghayegh Vahdat

    2015-07-01

    Full Text Available Background: Advances in science and technology and the changes in lifestyle have changed the concept of health in terms of etiology and mortality. The aim of this study was to test the psychometric properties of the original Patient Self-Advocacy Scale for use with an Iranian population. Methods: In the current study, 50 chronic patients between the ages of 25 and 75 were selected as samples. This study was conducted in May 2013 at Bou Ali Sina Hospital in Sari. The translation process and cultural adaptation of the Patient Self-Advocacy Scale were conducted. The face validity and content validity of the instrument were formally verified by analyzing the feedback of patients and health professionals. In order to evaluate questionnaire’s reliability, the intraclass correlation coefficient (ICC was calculated for each item and each domain; and the Cronbach’s alpha was calculated for the entire instruments and each domain. Results: Of the 50 patients participating in the study, 36% were male and 64% were female. The mean age of the patients was 42.5. To comply with the Iranian culture and the study target population, slight changes were applied to the process of translation and validation. In the present study, intraclass correlation coefficient for each item was 0.8-1, which demonstrates excellent reliability of the questionnaire. The Cronbach’s alpha value was 0.75 for overall scale. Conclusion: The Persian version of Patient Self-Advocacy Scale was valid and reliable. Hence, it can be used by public health researchers and health system policy makers for programming and offering patient-oriented health services based on patients’ comments, needs, and preferences.

  17. [Changes in the surgical treatment of breast cancer].

    Science.gov (United States)

    Taguchi, T

    1988-01-01

    The principle in surgery for breast cancer is to clean out and remove en masse the primary lesion within the breast as well as the lymph nodes (metastases) in the vicinity. This fundamental approach to surgical intervention was established by Halsted and Meyer at the close of the nineteenth century. This has been termed typical mastectomy to this day and standard radical mastectomy has been the method used. Later, a more expanded type of radical surgery was performed on somewhat more advanced cases, but a less radical approach then came about. Since 1960, the excision of nodes in the cerebrum and cerebellum was not used for early cancer, and in some cases a more conservative approach in which only part of the breasts was removed resulted, as Europe and the United States were heavily toward reduced operations. Thus, it was considered that axillary expurgation was needed, but that excision of nodes in the cerebrum and cerebellum was not essential in every case. One approach is less aggressive, whether as to the expurgation or excision of the surrounding area of the breast; in certain cases, treatment may be combined with radiation and the surgery minimized. The above-mentioned operative procedure which leaves brain nodes intact has been called modified radical mastectomy. This is subdivided into the Auchincloss method, in which modes in the cerebellum are extirpated, and the Patey method, in which the cerebral nodes are preserved. In Japan this approach has been used for breast cancer in Stage I and Stage II, with surgery gradually becoming the mainstream. Conservative breast operation procedures such as tumor extirpation, partial breast removal or segmental resection are still rare in Japan but very common in Europe and the United States. Since remote metastases frequently occur through the circulation in breast cancer, in recent years it has generally been regarded as a whole-body disease and, in terms of the advance of the cancer in each case, the method of

  18. Political activity for physical activity: health advocacy for active transport

    Directory of Open Access Journals (Sweden)

    Amun Qa-t-a

    2011-05-01

    Full Text Available Abstract Effective health advocacy is a priority for efforts to increase population participation in physical activity. Local councils are an important audience for this advocacy. The aim of the current study was to describe features of advocacy for active transport via submissions to city council annual plans in New Zealand, and the impact of an information sheet to encourage the health sector to be involved in this process. Written submissions to city council's annual consultation process were requested for 16 city councils over the period of three years (2007/08, 2008/09, and 2009/10. Submissions were reviewed and categories of responses were created. An advocacy information sheet encouraging health sector participation and summarising some of the evidence-base related to physical activity, active transport and health was released just prior to the 2009/10 submission time. Over the period of the study, city councils received 47,392 submissions, 17% of which were related to active transport. Most submissions came from city residents, with a small proportion (2% from the health sector. The largest category of submissions was in support of pedestrian and cycling infrastructure, design and maintenance of facilities and additional features to support use of these transport modes. Health arguments featured prominently in justifications for active transport initiatives, including concerns about injury risk, obesity, physical inactivity, personal safety and facilities for people with disabilities. There was evidence that the information sheet was utilised by some health sector submitters (12.5%, providing tentative support for initiatives of this nature. In conclusion, the study provides novel information about the current nature of health advocacy for active transport and informs future advocacy efforts about areas for emphasis, such as health benefits of active transport, and potential alliances with other sectors such as environmental

  19. Surviving and Thriving With Cancer Using a Web-Based Health Behavior Change Intervention: Randomized Controlled Trial

    OpenAIRE

    O'Carroll Bantum, Erin; Albright, Cheryl L.; White, Kami K.; Berenberg, Jeffrey L.; Layi, Gabriela; Ritter, Phillip L; Laurent, Diana; Plant, Katy; Lorig, Kate

    2014-01-01

    Background Given the substantial improvements in cancer screening and cancer treatment in the United States, millions of adult cancer survivors live for years following their initial cancer diagnosis and treatment. However, latent side effects can occur and some symptoms can be alleviated or managed effectively via changes in lifestyle behaviors. Objective The purpose of this study was to test the effectiveness of a six-week Web-based multiple health behavior change program for adult survivor...

  20. Expert and Advocacy Group Consensus Findings on the Horizon of Public Health Genetic Testing

    Directory of Open Access Journals (Sweden)

    Stephen M. Modell

    2016-01-01

    Full Text Available Description: Among the two leading causes of death in the United States, each responsible for one in every four deaths, heart disease costs Americans $300 billion, while cancer costs Americans $216 billion per year. They also rank among the top three causes of death in Europe and Asia. In 2012 the University of Michigan Center for Public Health and Community Genomics and Genetic Alliance, with the support of the Centers for Disease Control and Prevention Office of Public Health Genomics, hosted a conference in Atlanta, Georgia to consider related action strategies based on public health genomics. The aim of the conference was consensus building on recommendations to implement genetic screening for three major heritable contributors to these mortality and cost figures: hereditary breast and ovarian cancer (HBOC, familial hypercholesterolemia (FH, and Lynch syndrome (LS. Genetic applications for these three conditions are labeled with a “Tier 1” designation by the U.S. Centers for Disease Control and Prevention because they have been fully validated and clinical practice guidelines based on systematic review support them. Methodology: The conference followed a deliberative sequence starting with nationally recognized clinical and public health presenters for each condition, followed by a Patient and Community Perspectives Panel, working group sessions for each of the conditions, and a final plenary session. The 74 conference participants represented disease research and advocacy, public health, medicine and nursing, genetics, governmental health agencies, and industry. Participants drew on a public health framework interconnecting policy, clinical intervention, surveillance, and educational functions for their deliberations. Results: Participants emphasized the importance of collaboration between clinical, public health, and advocacy groups in implementing Tier 1 genetic screening. Advocacy groups could help with individual and institutional

  1. Expert and Advocacy Group Consensus Findings on the Horizon of Public Health Genetic Testing

    Science.gov (United States)

    Modell, Stephen M.; Greendale, Karen; Citrin, Toby; Kardia, Sharon L. R.

    2016-01-01

    Description: Among the two leading causes of death in the United States, each responsible for one in every four deaths, heart disease costs Americans $300 billion, while cancer costs Americans $216 billion per year. They also rank among the top three causes of death in Europe and Asia. In 2012 the University of Michigan Center for Public Health and Community Genomics and Genetic Alliance, with the support of the Centers for Disease Control and Prevention Office of Public Health Genomics, hosted a conference in Atlanta, Georgia to consider related action strategies based on public health genomics. The aim of the conference was consensus building on recommendations to implement genetic screening for three major heritable contributors to these mortality and cost figures: hereditary breast and ovarian cancer (HBOC), familial hypercholesterolemia (FH), and Lynch syndrome (LS). Genetic applications for these three conditions are labeled with a “Tier 1” designation by the U.S. Centers for Disease Control and Prevention because they have been fully validated and clinical practice guidelines based on systematic review support them. Methodology: The conference followed a deliberative sequence starting with nationally recognized clinical and public health presenters for each condition, followed by a Patient and Community Perspectives Panel, working group sessions for each of the conditions, and a final plenary session. The 74 conference participants represented disease research and advocacy, public health, medicine and nursing, genetics, governmental health agencies, and industry. Participants drew on a public health framework interconnecting policy, clinical intervention, surveillance, and educational functions for their deliberations. Results: Participants emphasized the importance of collaboration between clinical, public health, and advocacy groups in implementing Tier 1 genetic screening. Advocacy groups could help with individual and institutional buy-in of Tier 1

  2. Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer.

    Science.gov (United States)

    Palmer, Scott; Litvinova, Karina; Dunaev, Andrey; Fleming, Stewart; McGloin, David; Nabi, Ghulam

    2016-04-01

    Muscle invasive urinary bladder cancer is one of the most lethal cancers and its detection at the time of transurethral resection remains limited and diagnostic methods are urgently needed. We have developed a muscle invasive transitional cell carcinoma (TCC) model of the bladder using porcine bladder scaffold and the human bladder cancer cell line 5637. The progression of implanted cancer cells to muscle invasion can be monitored by measuring changes in the spectrum of endogenous fluorophores such as reduced nicotinamide dinucleotide (NADH) and flavins. We believe this could act as a useful tool for the study of fluorescence dynamics of developing muscle invasive bladder cancer in patients. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. PMID:27446646

  3. Changing trends of breast cancer awareness in young females of north India: A pilot study from a rural cancer hospital

    Directory of Open Access Journals (Sweden)

    Vivek Tiwari

    2014-01-01

    Full Text Available Aim: To assess the spectrum of presentation of young (18-35 years females to a rural cancer hospital and to correlate it with the level of education. Materials and Methods: Ninety cases of the selected age group were prospectively studied for the manner of presentation and level of education. Results: Majority patients (57.77% presented with breast related symptoms. 81.1% of the patients were educated at least up to secondary school education. Conclusions: Owing to the improved education levels and awareness, the young rural females are more informed about breast related symptoms and are seeking proper care for the same. A robust rural cancer registry system may document this changing scenario that may well contrast with the traditional beliefs and learning of cancer epidemiology.

  4. Conservation Through Different Lenses: Reflection, Responsibility, and the Politics of Participation in Conservation Advocacy

    Science.gov (United States)

    Abrash Walton, Abigail

    2010-01-01

    This essay considers the arenas of advocacy, politics, and self-reflection in strengthening conservation and resource management initiatives. It frames key questions that reflective conservation practitioners may address in seeking to enhance the results of conservation projects, including equity and more inclusive participation by nonprivileged groups. The essay touches on the importance of understanding conservation work within particular political and historic dynamics, including the need to understand non-Western and/or indigenous or traditional perspectives on conservation. The author makes the case that Western or privileged conservation practitioners are uniquely situated to advocate effectively for change.

  5. The Nature, Correlates, and Conditions of Parental Advocacy in Special Education

    Science.gov (United States)

    Burke, Meghan M.; Hodapp, Robert M.

    2016-01-01

    Although parents often advocate for the best educational services for their children with disabilities, few studies examine parents' advocacy activities; identify parent-school relationship, parent, and student correlates of advocacy; or describe the conditions of advocacy. Responding to a national, web-based survey, 1087 parents of students with…

  6. 45 CFR 1386.20 - Designated State Protection and Advocacy agency.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Designated State Protection and Advocacy agency... Advocacy of the Rights of Individuals with Developmental Disabilities § 1386.20 Designated State Protection and Advocacy agency. (a) The designating official must designate the State official or public...

  7. 45 CFR 1386.21 - Requirements and authority of the Protection and Advocacy System.

    Science.gov (United States)

    2010-10-01

    ... Advocacy System. 1386.21 Section 1386.21 Public Welfare Regulations Relating to Public Welfare (Continued... Protection and Advocacy of the Rights of Individuals with Developmental Disabilities § 1386.21 Requirements and authority of the Protection and Advocacy System. (a) In order for a State to receive...

  8. 42 CFR 51.7 - Eligibility for protection and advocacy services.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Eligibility for protection and advocacy services... REQUIREMENTS APPLICABLE TO THE PROTECTION AND ADVOCACY FOR INDIVIDUALS WITH MENTAL ILLNESS PROGRAM Basic Requirements § 51.7 Eligibility for protection and advocacy services. In accordance with section...

  9. 45 CFR 1386.24 - Non-allowable costs for the Protection and Advocacy System.

    Science.gov (United States)

    2010-10-01

    ... Advocacy System. 1386.24 Section 1386.24 Public Welfare Regulations Relating to Public Welfare (Continued... Protection and Advocacy of the Rights of Individuals with Developmental Disabilities § 1386.24 Non-allowable costs for the Protection and Advocacy System. (a) Federal financial participation is not allowable...

  10. 34 CFR 381.1 - What is the Protection and Advocacy of Individual Rights program?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false What is the Protection and Advocacy of Individual Rights program? 381.1 Section 381.1 Education Regulations of the Offices of the Department of Education... ADVOCACY OF INDIVIDUAL RIGHTS General § 381.1 What is the Protection and Advocacy of Individual...

  11. 75 FR 11999 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2010-03-12

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comment... the Federal Advisory Committee Act, 5 U.S.C. App. (1988) that an open meeting of the Taxpayer...

  12. 78 FR 22948 - Open Meeting of the Taxpayer Advocacy Panel Tax Forms and Publications Project Committee

    Science.gov (United States)

    2013-04-17

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Tax Forms and Publications Project... meeting of the Taxpayer Advocacy Panel Tax Forms and Publications Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer...

  13. 78 FR 41193 - Open Meeting of the Taxpayer Advocacy Panel Tax Forms and Publications Project Committee

    Science.gov (United States)

    2013-07-09

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Tax Forms and Publications Project... meeting of the Taxpayer Advocacy Panel Tax Forms and Publications Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer...

  14. 75 FR 25316 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2010-05-07

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comment... the Federal Advisory Committee Act, 5 U.S.C. App. (1988) that an open meeting of the Taxpayer...

  15. 78 FR 78516 - Open Meeting of the Taxpayer Advocacy Panel Tax Forms and Publications Project Committee.

    Science.gov (United States)

    2013-12-26

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Tax Forms and Publications Project... meeting of the Taxpayer Advocacy Panel Tax Forms and Publications Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer...

  16. 76 FR 10945 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2011-02-28

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... the Federal Advisory Committee Act, 5 U.S.C. App. (1988) that an open meeting of the Taxpayer...

  17. 75 FR 39332 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2010-07-08

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comment... the Federal Advisory Committee Act, 5 U.S.C. App. (1988) that an open meeting of the Taxpayer...

  18. 75 FR 7542 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2010-02-19

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comment... the Federal Advisory Committee Act, 5 U.S.C. App. (1988) that an open meeting of the Taxpayer...

  19. 76 FR 6190 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2011-02-03

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... the Federal Advisory Committee Act, 5 U.S.C. App. (1988) that an open meeting of the Taxpayer...

  20. 78 FR 78516 - Open Meeting of the Taxpayer Advocacy Panel Notices and Correspondence Project Committee

    Science.gov (United States)

    2013-12-26

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Notices and Correspondence Project... meeting of the Taxpayer Advocacy Panel Notices and Correspondence Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas, and suggestions on improving customer...

  1. 76 FR 17996 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2011-03-31

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... the Federal Advisory Committee Act, 5 U.S.C. App. (1988) that an open meeting of the Taxpayer...

  2. 78 FR 22948 - Open Meeting of the Taxpayer Advocacy Panel Notices and Correspondence Project Committee

    Science.gov (United States)

    2013-04-17

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Notices and Correspondence Project... meeting of the Taxpayer Advocacy Panel Notices and Correspondence Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas, and suggestions on improving customer...

  3. 78 FR 36303 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2013-06-17

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... the Federal Advisory Committee Act, 5 U.S.C. App. (1988) that an open meeting of the Taxpayer...

  4. 76 FR 22170 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2011-04-20

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... of the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  5. 77 FR 30591 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee.

    Science.gov (United States)

    2012-05-23

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee. AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... the Federal Advisory Committee Act, 5 U.S.C. App. (1988) that an open meeting of the Taxpayer...

  6. 77 FR 21156 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2012-04-09

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... the Federal Advisory Committee Act, 5 U.S.C. App. (1988) that an open meeting of the Taxpayer...

  7. 76 FR 22168 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2011-04-20

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... the Federal Advisory Committee Act, 5 U.S.C. App. (1988) that an open meeting of the Taxpayer...

  8. 78 FR 22947 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2013-04-17

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... the Federal Advisory Committee Act, 5 U.S.C. App. (1988) that an open meeting of the Taxpayer...

  9. 78 FR 41194 - Open Meeting of the Taxpayer Advocacy Panel Notices and Correspondence Project Committee

    Science.gov (United States)

    2013-07-09

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Notices and Correspondence Project... meeting of the Taxpayer Advocacy Panel Notices and Correspondence Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas, and suggestions on improving customer...

  10. 78 FR 28945 - Open Meeting of the Taxpayer Advocacy Panel Joint Committee

    Science.gov (United States)

    2013-05-16

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Joint Committee AGENCY: Internal... Advocacy Panel Joint Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments... the Federal Advisory Committee Act, 5 U.S.C. App. (1988) that an open meeting of the Taxpayer...

  11. 75 FR 25316 - Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee

    Science.gov (United States)

    2010-05-07

    ... Internal Revenue Service Open Meeting of Taxpayer Advocacy Panel Notice Improvement Project Committee... of the Taxpayer Advocacy Panel Notice Improvement Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas and suggestions on improving customer service at...

  12. Anatomy of Advocacy: A Case Study of the White House Petition

    Science.gov (United States)

    Burns, Elizabeth; Kimmel, Sue; Dickinson, Gail

    2016-01-01

    Little research has been conducted examining advocacy efforts in the school library field despite the fact that program advocate is a prominent role for school librarians. One element of advocacy is the engagement in political initiatives that may affect school library programs. This case study investigates the effectiveness of one advocacy effort…

  13. Changing constituents of genitourinary cancer in recent 50 years in Beijing

    Institute of Scientific and Technical Information of China (English)

    顾方六

    2003-01-01

    Objective To assess the changes in constituents of genitourinary cancer inpatients in Beijing following the growing economy of China.Methods Urological inpatients treated from January 1951 to December 2000 at the Institute of Urology, Peking University were studied restrospectively.Results In the period of about 50 years 28 474 urological inpatients were reviewed. Cancer patients aged 0-25 years and 26-50 years comprised 19.5% and 28.2%, respectively. Since the 1970s the incidence rates of renal cancer and prostate cancer increased dramatically from 10.4% to 28.7% and from 3.3% to 13.4%, respectively.Conclusion The introduction of new diagnostic instruments, the expansion of the aged population and a high fat diet are considered to be responsible for the change of constituents of genitourimary concer inpatients.

  14. Senior Centers and Policy Advocacy: Changing Public Perceptions

    Science.gov (United States)

    Pardasani, Manoj; Goldkind, Lauri

    2012-01-01

    As critical components of the aging continuum of care, senior centers promote older adult health and well-being by providing opportunities for recreation, socialization, nutrition, health education, and access to vital social services. Nationally, a vast network of 11,000 senior centers serves over four million older adults annually. As the United…

  15. THE ROLE OF POLICY ENTREPRENEURS AND ADVOCACY NETWORKS IN PUBLIC POLICY PROCESS (STUDY CASE OF BRAZIL WATER POLICY REFORM)

    OpenAIRE

    KOVERZNEVA S.A.; KULAKOVA T.A.

    2015-01-01

    The diversity in social demands does expand the quantity of possible alternative policies and requires the changes in public governance. New strategy of governance involves dialogue among stakeholders. Various social and professional networks, united shared values, interests and beliefs could have more motivational potential for innovations, than traditional administrative approach. Key question is the role of informal advocacy groups and policy entrepreneurs in such shift. The paper examines...

  16. Image and pathological changes after microwave ablation of breast cancer: A pilot study

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Wenbin [Department of Breast Surgery, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 (China); Jiang, Yanni [Department of Radiology, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 (China); Chen, Lin; Ling, Lijun; Liang, Mengdi; Pan, Hong [Department of Breast Surgery, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 (China); Wang, Siqi [Department of Radiology, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 (China); Ding, Qiang [Department of Breast Surgery, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 (China); Liu, Xiaoan, E-mail: liuxiaoan@126.com [Department of Breast Surgery, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 (China); Wang, Shui, E-mail: ws0801@hotmail.com [Department of Breast Surgery, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029 (China)

    2014-10-15

    Highlights: • We report successful experience of MWA in breast cancer under local anesthesia. • We report MR imaging evaluation of microwave ablation zone in breast cancer. • Pathological changes after microwave ablation in breast cancer was reported. • 2 min MWA caused an ablation zone with three diameters > 2 cm in breast cancer. - Abstract: Purpose: To prospectively assess MR imaging evaluation of the ablation zone and pathological changes after microwave ablation (MWA) in breast cancer. Materials and methods: Twelve enrolled patients, diagnosed with non-operable locally advanced breast cancer (LABC), were treated by MWA and then neoadjuvant chemotherapy, followed by surgery. MR imaging was applied to evaluate the effect of MWA. Hematoxylin-eosin (HE) staining and transmission electron microscopy (TEM) were applied to analyze the ablated area. Results: All MWA procedures were performed successfully under local anesthesia. For a mean duration of 2.15 min, the mean largest, middle and smallest diameters in the ablated zone 24-h post-ablation in MR imaging were 2.98 cm ± 0.53, 2.51 cm ± 0.41 and 2.23 cm ± 0.41, respectively. The general shape of the ablation zone was close to a sphere. The ablated area became gradually smaller in MR imaging. No adverse effects related to MWA were noted in all 12 patients during and after MWA. HE staining could confirm the effect about 3 months after MWA, which was confirmed by TEM. Conclusions: 2 min MWA can cause an ablation zone with three diameters larger than 2 cm in breast cancer, which may be suitable for the local treatment of breast cancer up to 2 cm in largest diameter. However, the long-term effect of MWA in the treatment of small breast cancer should be determined in the future.

  17. Electronic game: A key effective technology to promote behavioral change in cancer patients.

    Science.gov (United States)

    Safdari, Reza; Ghazisaeidi, Marjan; Goodini, Azadeh; Mirzaee, Mahboobeh; Farzi, Jebraeil

    2016-01-01

    Cancer diagnosis is a very unpleasant and unbelievable experience. Appropriate management and treatment of these diseases require a high degree of patient engagement. Interactive health electronic games are engaging, fun, challenging, and experiential and have the potential to change the attitude and behavior, which can improve the player's health. The use of these digital tools, as one of the most attractive and entertaining modern technologies, canem power patients, provide suitable palliative care, promote health behavior change strategies, increase patient engagement, enhance healthy lifestyle habits, improve self.management, and finally improve the quality of life of the patients. Finally, the aim of this article was to describe electronic games and their effects on the promotion of behavior change in cancer patients. In addition, this article describes categories, characteristic features, and benefits of this digital media in the lifestyle modification of cancer patients. PMID:27461596

  18. Corporate Advocacy: A Selected Review of the Literature.

    Science.gov (United States)

    Dionisopoulos, George N.; Hellweg, Susan A.

    This paper provides a selected review of the literature pertaining to corporate advocacy (non-product advertising by corporations, addressing political or social issues). More specifically, the paper examines research from the communication, business, public relations, and advertising literature dealing with justifications for the practice of…

  19. Exploring the Future of Lifelong Learning: Advocacy, Research and Footprinting

    Science.gov (United States)

    Chisholm, Lynne

    2013-01-01

    This reflective think-tank contribution begins by comparing advocacy and research as distinct modalities of professional and social action. In practice they frequently elide and merge into one another. While alliance and complementarity between the two modalities is constructive for shaping policy and practice, it poses risks when governments and…

  20. Critical Literacy as Policy and Advocacy: Lessons from Colombia

    Science.gov (United States)

    Mora, Raúl Alberto

    2014-01-01

    This article, the first column for this issue's Policy and Advocacy department, features a discussion about a recent experience in a graduate program in Medellín, Colombia introducing students to critical literacy. Graduate students used ideas from critical literacy to engage in an in-depth analysis of textbooks they had used in their…

  1. Participatory Video: Toward a Method, Advocacy and Voice (MAV) Framework

    Science.gov (United States)

    Sitter, Kathleen C.

    2012-01-01

    Using the new conceptual framework of participatory visual media as method, advocacy and voice (MAV), the author explores an action research study using an exemplar in which advocates from the disability community created and distributed a series of videos about love and sexuality as a critical human rights issue in the disability community. The…

  2. Citizen Advocacy for the Handicapped, Impaired, and Disadvantaged: An Overview.

    Science.gov (United States)

    Wolfensberger, Wolf

    Discussed in terms of instrumental and expressive functions are citizen advocacy programs for mentally or physically handicapped children and adults. Instrumental functions are defined as meeting the practical needs of everyday life while expressive functions are said to involve an exchange of affection which meets emotional needs. Major types of…

  3. Latina/o School Principals: Identity, Leadership and Advocacy

    Science.gov (United States)

    Murakami, Elizabeth T.; Hernandez, Frank; Mendez-Morse, Sylvia; Byrne-Jimenez, Monica

    2016-01-01

    This study sought to further define and inform about the influence of Latina/o principals in schools as an alternative to traditional forms of leadership. The principals' Latina/o identity, their leadership styles and advocacy towards the improvement of student achievement were examined. This research focused on three questions: (a) How did…

  4. Teaching Advocacy in Early Years Initial Teacher Education Programmes

    Science.gov (United States)

    Liebovich, Betty J.; Matoba Adler, Susan

    2009-01-01

    Teacher education programmes in the United States and in England with early childhood certification usually include courses with topics such as early childhood theory and curriculum, child development, model programs, and history of early childhood education but less often include courses with content focused specifically on advocacy. This article…

  5. Service Learning as Justice Advocacy: Can Political Scientists Do Politics?

    Science.gov (United States)

    Robinson, Tony

    2000-01-01

    Provides background information on the topic of service learning and discusses the two variations of service learning: (1) providing charitable services; and (2) engaging students in political organizing and social advocacy. Focuses on the Westside Outreach Center and the Urban Citizen Project at the University of Colorado (Denver). (CMK)

  6. Advocacy for active transport: advocate and city council perspectives

    Directory of Open Access Journals (Sweden)

    Rosenby Marieah

    2010-01-01

    Full Text Available Abstract Background Effective advocacy is an important part of efforts to increase population participation in physical activity. Research about effective health advocacy is scarce, however, the health sector can learn from the experiences and knowledge of community advocates and those who are on the receiving end of this advocacy. The aim of this study is to explore advocacy for active transport from the perspectives of community advocates and representatives from City councils. Methods Cycling and walking advocates were identified from the local contact list of Cycling Advocates Network and Living Streets Aotearoa. Semi-structured telephone interviews were conducted with cycle and walking advocates from throughout New Zealand. Advocates also nominated a suitable council officer at their local City council to be interviewed. Interviews were recorded and transcribed and categories of responses for each of the questions created. Results Several processes were used by advocates to engage with council staff, including formal council submissions, meetings, stakeholder forums and partnership in running community events promoting active transport. Several other agencies were identified as being influential for active transport, some as potential coalition partners and others as potential adversaries. Barriers to improving conditions for active transport included a lack of funding, a lack of will-power among either council staff or councillors, limited council staff capacity (time or training and a culture of providing infrastructure for motor vehicles instead of people. Several suggestions were made about how the health sector could contribute to advocacy efforts, including encouraging political commitment, engaging the media, communicating the potential health benefits of active transport to the general public and being role models in terms of personal travel mode choice and having workplaces that support participation in active transport

  7. Voices from the Margins: Policy Advocacy and Marginalized Communities

    Directory of Open Access Journals (Sweden)

    Gloria DeSantis

    2010-01-01

    Full Text Available This article aims to explore policy advocacy processes facilitated by social service nonprofit organizations (NPOs using a social justice lens. Qualitative interview results from 39 NPOs from 18 communities provide a deeper understanding of advocacy, revealing that NPOs perceive that policy advocacy is not a discrete phenomenon, that advocacy activity differs in visibility and scale, and that advocacy strategies are clearly informed by NPOs' front-line service delivery work. A typology of policy advocacy showing different advocacy types and their fluid nature is presented. The results also show that marginalized people's involvement varies depending on a diversity of influential conditions. Conclusions and implications focus on social inclusion/exclusion, the varied and fluid nature of policy advocacy, challenges for practitioners, and the complex nature of "advocacy chill. / "Les organismes sans but lucratif (OSBL de services sociaux ont pour mission de préserver la santé des communautés au moyen de défense de politiques sociales. Toutefois, peu d'études concrètes au Canada portent sur la nature des processus en cause, en particulier lorsqu'il s'agit de politiques mises en œuvre au sein de collectivités marginalisées. Cet article a pour but d'explorer sous l'angle de la justice sociale la nature des processus défense des politiques tels qu'ils sont pratiqués par les OSBL de services sociaux. Un entretien qualitatif avec 39 OSBL issues de 18 collectivités permet une meilleure compréhension des processus. Les OSBL ne conçoivent pas défense des politiques comme un phénomène discret; les activités qui y sont reliées varient en visibilité et en étendue, et les stratégies employées sont clairement influencées par les services de première ligne qu'offrent les OSBL. Nous proposons une typologie des processus défense des politiques exposant les différents types d'approches et leur nature changeante. Les résultats indiquent

  8. Screening prior to Breast Cancer Diagnosis: The More Things Change, the More They Stay the Same

    Directory of Open Access Journals (Sweden)

    Erica B. Friedman

    2013-01-01

    Full Text Available Purpose. In November 2009, the U.S. Preventative Service Task Force (USPSTF revised their breast cancer screening guidelines. We evaluated the pattern of screening subsequent to the altered guidelines in a cohort of women. Methods. Our database was queried for the following variables: age, race, method of diagnosis, mass palpability, screening frequency, histology, and stage. Statistical analyses were performed using Pearson’s chi-square and Fisher’s exact tests. Results. 1112 women were diagnosed with breast cancer from January 2010 to 2012. The median age at diagnosis was 60 years. Most cancers were detected on mammography (61%. The majority of patients had invasive ductal carcinoma (59%, stage 0 (23%, and stage 1 (50% cancers. The frequency of screening did not change significantly over time (P=0.30. However, nonregular screeners had an increased risk of being diagnosed with later stage breast cancer (P<0.001 and were more likely to present with a palpable mass compared to regular screeners (56% versus 21%; P<0.001. Conclusions. In our study, screening behavior did not significantly change in the years following the USPSTF guidelines. These results suggest that women who are not screened annually are at increased risk of a delay in breast cancer diagnosis, which may impact treatment options and outcomes.

  9. A Research Agenda for Appearance Changes Due to Breast Cancer Treatment

    Directory of Open Access Journals (Sweden)

    Mia K. Markey

    2008-01-01

    Full Text Available Breast cancer is one of the most prevalent forms of cancer in the US. It is estimated that more than 180,000 American women will be diagnosed with invasive breast cancer in 2008. Fortunately, the survival rate is relatively high and continually increasing due to improved detection techniques and treatment methods. However, maintaining quality of life is a factor often under emphasized for breast cancer survivors. Breast cancer treatments are invasive and can lead to deformation of the breast. Breast reconstruction is important for restoring the survivor’s appearance. However, more work is needed to develop technologies for quantifying surgical outcomes and understanding women’s perceptions of changes in their appearance. A method for objectively measuring breast anatomy is needed in order to help both the breast cancer survivors and their surgeons take expected changes to the survivor’s appearance into account when considering various treatment options. In the future, augmented reality tools could help surgeons reconstruct a survivor’s breasts to match her preferences as much as possible.

  10. Recent changes in bacteremia in patients with cancer: a systematic review of epidemiology and antibiotic resistance.

    Science.gov (United States)

    Montassier, E; Batard, E; Gastinne, T; Potel, G; de La Cochetière, M F

    2013-07-01

    Bacteremia remains a major cause of life-threatening complication in patients with cancer. Significant changes in the spectrum of microorganisms isolated from blood culture have been reported in cancer patients over the past years. The aim of our systematic review was to inventory the recent trends in epidemiology and antibiotic resistance of microorganisms causing bacteremia in cancer patients. Data for this review was identified by searches of Medline, Scopus and Cochrane Library for indexed articles and abstracts published in English since 2008. The principal search terms were: "antimicrobial resistance", "bacteremia", "bacterial epidemiology", "bloodstream infection", "cancer patients", "carbapenem resistance", "Escherichia coli resistance", "extended-spectrum β-lactamase producing E. coli", "febrile neutropenia", "fluoroquinolone resistance", "neutropenic cancer patient", "vancomycin-resistant Enterococcus", and "multidrug resistance". Boolean operators (NOT, AND, OR) were also used in succession to narrow and widen the search. Altogether, 27 articles were selected to be analyzed in the review. We found that Gram-negative bacteria were the most frequent pathogen isolated, particularly in studies with minimal use of antibiotic prophylaxis. Another important trend is the extensive emergence of antimicrobial-resistant strains associated with increased risk of morbidity, mortality and cost. This increasing incidence of antibiotic resistance has been reported in Gram-negative bacteria as well as in Gram-positive bacteria. This exhaustive review, reporting the recent findings in epidemiology and antibiotic resistance of bacteremia in cancer patients, highlights the necessity of local continuous surveillance of bacteremia and stringent enforcement of antibiotic stewardship programs in cancer patients. PMID:23354675

  11. From Individuals to International Policy: Achievements and Ongoing Needs in Diabetes Advocacy.

    Science.gov (United States)

    Hilliard, Marisa E; Oser, Sean M; Close, Kelly L; Liu, Nancy F; Hood, Korey K; Anderson, Barbara J

    2015-09-01

    Diabetes impacts tens of millions of people in the United States of America and 9 % of the worldwide population. Given the public health implications and economic burden of diabetes, the needs of people with diabetes must be addressed through strategic and effective advocacy efforts. Diabetes advocacy aims to increase public awareness about diabetes, raise funds for research and care, influence policy impacting people with diabetes, and promote optimal individual outcomes. We present a framework for diabetes advocacy activities by individuals and at the community, national, and international levels and identify challenges and gaps in current diabetes advocacy. Various groups have organized successful diabetes advocacy campaigns toward these goals, and lessons for further advancing diabetes advocacy can be learned from other health-related populations. Finally, we discuss the role of healthcare providers and mental/behavioral health professionals in advocacy efforts that can benefit their patients and the broader population of people with diabetes.

  12. Continuity of care in addictions treatment: the role of advocacy and coordination in case management.

    Science.gov (United States)

    Graham, K; Timney, C B; Bois, C; Wedgerfield, K

    1995-11-01

    Although advocacy and coordination are recognized as important aspects of the addictions treatment process, little research has been done in these areas. The present study examined advocacy and coordination at two programs where the mandate was assessment, referral, and case management. Both programs spent a similar proportion of client-related effort on advocacy and/or coordination (about 25% of contact time, accounting for about half of contacts made regarding clients). The majority of advocacy and coordination contacts were with other agencies about clients (the remainder with family and friends of clients). A framework for advocacy and coordination was developed that allowed contacts to be categorized into mutually exclusive advocacy or coordination activities. Advocacy was defined as any activity undertaken to obtain something for clients; coordination involved the giving or receiving of information regarding specific clients. Sources of variability in the provision of advocacy and coordination were found between the programs that could be attributed to differences between the systems within which the programs operated, as well as differences in program clientele. In terms of client characteristics, it was found that females were more likely than males to receive advocacy; those over 65 years were most likely to receive both advocacy and coordination; those who were referred by school or employer or by corrections were most likely to receive coordination; those with no prior treatment were most likely to receive advocacy; and self-referrals and those who had had prior treatment were most likely to receive neither advocacy nor coordination. Receiving advocacy or coordination was not found to reduce the need by clients for other case management services, such as supportive counseling. The findings are discussed in terms of the need for knowledge regarding highly variable aspects of treatment such as advocacy and coordination. New research approaches (as taken in

  13. Anthropometric Changes Using a Walking Intervention in African American Breast Cancer Survivors: A Pilot Study

    Directory of Open Access Journals (Sweden)

    James Kilpatrick, PhD

    2005-03-01

    Full Text Available Introduction African American women exhibit a higher mortality rate from breast cancer than do white women. African American women are more likely to gain weight at diagnosis, which may increase their risk of cancer recurrence and comorbidities. Physical activity has been shown to decrease body mass index and improve quality of life in cancer survivors. This study was designed to evaluate the feasibility and impact of a community-based exercise intervention in African American breast cancer survivors. Methods A theory-based eight-week community intervention using pedometers with scheduling, goal setting, and self-assessment was tested in a convenience sample of African American breast cancer survivors (n = 24. Data were collected at three time points to examine changes in steps walked per day, body mass index, and other anthropometric measures, attitudes, and demographic variables. Results Statistically significant increases in steps walked per day and attitude toward exercise as well as significant decreases in body mass index, body weight, percentage of body fat, and waist, hip, and forearm circumferences, as well as blood pressure, were reported from baseline to immediate post-intervention. Positive changes were retained or improved further at three-month follow-up except for attitude toward exercise. Participant retention rate during eight-week intervention was 92%. Conclusion Increasing walking for exercise, without making other changes, can improve body mass index, anthropometric measures, and attitudes, which are associated with improved quality of life and reduced risk of cancer recurrence. The high participant retention rate, along with significant study outcomes, demonstrate that among this sample of African American breast cancer survivors, participants were motivated to improve their exercise habits.

  14. Weight Change and Associated Factors in Long-Term Breast Cancer Survivors

    Science.gov (United States)

    Koo, Hye-Yeon; Seo, Young-Gyun; Cho, Mi-Hee; Kim, Min-Jung; Choi, Ho-Chun

    2016-01-01

    Purpose Weight gain often occurs after breast cancer diagnosis and significantly impacts the general health of cancer survivors. While the number of breast cancer survivors is increasing, few studies have reported data on weight change beyond 5 years post-diagnosis. We investigated weight change and associated factors in long-term survivors of breast cancer. Patients and Methods Medical records were reviewed on 1363 breast cancer patients and a total of 822 women who had survived beyond 5 years since diagnosis were included in the final analysis. The association between demographic, anthropometric, lifestyle, cancer related factors (including time since diagnosis, treatment modality, pathologic stage, and hormone receptor status), and weight-change over 5 years were examined. Results During an average 8.2 years of follow-up time, mean weight gain was 0.32kg (p = 0.017). 175 (21.3%) patients had gained more than 5% of their weight at diagnosis and their average gain was 5.55kg. Body mass index (BMI) at diagnosis, age at diagnosis, aromatase inhibitor (AI) use, heavy drinking, and type of surgery were associated with relative weight gain (≥5%) in univariate analysis (all p-valuesAI showed odds ratio of 2.2 (p = 0.006) relative to women who did. Conclusion Long-term breast cancer survivors who were non-obese at diagnosis are more likely to gain weight than obese survivors. Younger survivors and survivors who have never used AI are also likely to gain weight. PMID:27391162

  15. Survey of changes in dietary preferences in cancer patients in China

    Institute of Scientific and Technical Information of China (English)

    Jing Li; Liqiong Zhang; Qiujun Tang; Xianglin Yuan 

    2015-01-01

    Objective The aim of this study was to investigate the changes in dietary preferences in cancer patients in China and to determine the need for encouraging the adherence to a sensible diet among such patients. Methods A total of 468 cancer patients were interviewed using a self-designed questionnaire focusing on changes in the intake of specific foods. Data were analyzed using SPSS 16.0. Results Most patients completely avoided roosters and carp (73.1%), condiments (51.9%), and meat of aquatic species (40.4%). Al other types of the specific foods were completely avoided by dif erent sub-populations of the patients. Conclusion In addition to focusing on disease treatment, medical professionals need to help cancer pa-tients overcome barriers associated with the customs of avoiding specific foods encompassed by the term ”fawu” and provide them with dietary guidance in order to prevent negative nutritional ef ects.

  16. Changes in knowledge of cervical cancer following introduction of human papillomavirus vaccine among women at high risk for cervical cancer

    Science.gov (United States)

    Stewart Massad, L.; Evans, Charlesnika T.; Weber, Kathleen M.; D'Souza, Gypsyamber; Hessol, Nancy A.; Wright, Rodney L.; Colie, Christine; Strickler, Howard D.; Wilson, Tracey E.

    2015-01-01

    Purpose To describe changes in knowledge of cervical cancer prevention, human papillomavirus (HPV), and HPV vaccination among women at high risk for cervical cancer in the first five years after introduction of HPV vaccination. Methods In 2007, 2008–9, and 2011, women in a multicenter U.S. cohort study completed 44-item self-report questionnaires assessing knowledge of cervical cancer prevention, HPV, and HPV vaccination. Results across time were assessed for individuals, and three study enrollment cohorts were compared. Knowledge scores were correlated with demographic variables, measures of education and attention, and medical factors. Associations were assessed in multivariable models. Results In all, 974 women completed three serial questionnaires; most were minority, low income, and current or former smokers. The group included 652 (67%) HIV infected and 322 (33%) uninfected. Summary knowledge scores (possible range 0–24) increased from 2007 (12.8, S.D. 5.8) to 2008–9 (13.9, S.D. 5.3, P < 0.001) and to 2011 (14.3, S.D. 5.2, P < 0.0001 vs 2007 and < 0.04 vs 2008–9). Higher knowledge scores at first and follow-up administration of questionnaires, higher income, and higher education level were associated with improved knowledge score at third administration. Women not previously surveyed had scores similar to those of the longitudinal group at baseline. Conclusion Substantial gaps in understanding of HPV and cervical cancer prevention exist despite years of health education. While more effective educational interventions may help, optimal cancer prevention may require opt-out vaccination programs that do not require nuanced understanding. PMID:25870859

  17. CHANGES IN NUTRITIONAL STATUS AND DIETARY INTAKE DURING AND AFTER HEAD AND NECK CANCER TREATMENT

    NARCIS (Netherlands)

    Jager-Wittenaar, Harriet; Dijkstra, Pieter U.; Vissink, Arjan; Langendijk, Johannes A.; van der Laan, Bernard F. A. M.; Pruim, Jan; Roodenburg, Jan L. N.

    2011-01-01

    Background. The purpose of this study was to test whether nutritional status of patients with head and neck cancer changes during and after treatment. Methods. Nutritional status (including body weight, lean mass, and fat mass) and dietary intake were assessed in 29 patients with head and neck cance

  18. Acute chemotherapy-induced cardiovascular changes in patients with testicular cancer

    NARCIS (Netherlands)

    Nuver, J; Smit, AJ; van der Meer, J; van den Berg, MP; van der Graaf, WTA; Meinardi, MT; Sleijfer, DT; Hoekstra, HJ; van Gessel, AI; van Roon, AM; Gietema, JA

    2005-01-01

    Purpose; After cisplatin- and bleomycin-containing chemotherapy for testicular cancer, part of the patient population will develop acute or long-term cardiovascular toxicity. It is largely unknown whether standard tests can be used to assess chemotherapy-induced cardiovascular changes. Patients and

  19. Changes in body mass index in long-term childhood cancer survivors

    NARCIS (Netherlands)

    van Santen, HM; Geskus, Ronald B; Raemaekers, Steven; van Trotsenburg, A S Paul; Vulsma, Thomas; van der Pal, Helena J H; Caron, Hubert N; Kremer, Leontien C M

    2015-01-01

    BACKGROUND: Previous studies have reported changes in the body mass index (BMI) with time in childhood cancer survivors (CCSs) during follow-up. The limitations of these studies include that they described only a subgroup of survivors or used questionnaires with self-reported heights and weights. Th

  20. Changes in plasma TIMP-1 levels after resection for primary colorectal cancer

    DEFF Research Database (Denmark)

    Frederiksen, C.; Lomholt, A.F.; Davis, G.J.;

    2009-01-01

    BACKGROUND: Increased plasma levels of tissue inhibitor of metalloproteinases (TIMP-1) are associated with poor outcome in colorectal cancer (CRC), however postoperative changes in plasma TIMP-1 levels after resections for CRC have not been thoroughly evaluated. MATERIALS AND METHODS: Plasma samp...

  1. Changes in symptoms and pain intensity of cancer patients after enrollment in palliative care at home

    NARCIS (Netherlands)

    Dumitrescu, Luminita; van den Heuvel-Olaroiu, Marinela; van den Heuvel, Wim J. A.

    2007-01-01

    This study describes the activities and interventions carried out by an at-home palliative care team treating cancer patients who died within two years of being enrolled in a palliative care program. It analyzes which changes in symptoms and pain occurred and which sociodemographic and medical chara

  2. Multiple Health Behavior Changes in a Cancer Prevention Intervention for Construction Workers, 2001-2003

    OpenAIRE

    Harley, Amy E.; Devine, Carol M.; Beard, Binta; Stoddard, Anne M.; Hunt, Mary K.; Sorensen, Glorian

    2010-01-01

    Introduction: Few multiple behavior change interventions have addressed tobacco use in conjunction with fruit and vegetable consumption, particularly among high-risk blue-collar workers. Tools for Health, a cancer prevention intervention for construction laborers, was effective in achieving behavior change for smoking cessation and fruit and vegetable consumption separately. This study examines whether addressing smoking and fruit and vegetable consumption was successful in achieving positive...

  3. The Changes of Blood Coagulation in Surgical Patients with Lung Cancer

    Directory of Open Access Journals (Sweden)

    Xiangning FU

    2010-02-01

    Full Text Available Background and objective Patients with malignant tumor are at high risk of thrombophilia, which contributes to thromboembolism. Surgical treatment is one of the critical risk factors. In this study, changes and clinical significances of blood coagulation of lung cancer patients pre- and post operation were investigated. Methods A prospective, controlled study were carried out in 74 lung disease patients, who were divided into lung cancer group and benign lung disease group. In each group, pre-and postoperative changes in prothrombin time (PT, activated partial thromboplastin time (APTT, platelet count (PLT, D-dimer (D-D and fibrinogen (Fib and clinical performances were observed and compared in intra- and intergroups. Results The concentration of Fib both in lung cancer group and its subgroup (adenocarcinoma of lung increased, preoperative differences between benign lung disease group and subgroup (squamous cell carcinoma of lung was significant (P < 0.05. PT(postoperative 1st to7th day in lung cancer group prolonged, APTT (postoperative 3rd to7th day reduced, Fib (postoperative 3rd to7th day and D-D (postoperative 1st to 7th day increased, PLT reduced on the 1st, 3rd day but then increased on the 5th, 7th day after operation, the difference between pre- and post-operation was significant (P < 0.05. D-D and PT in lung cancer group on the 7th day was longer than in benign lung disease group (P < 0.05. One pulmonary thromboembolism (PTE case in lung cancer group occurred, while in benign lung disease group none venous thromboembolism (VTE appeared. Conclusion Patients with lung cancer are in high hypercoagulable state, and prone to VTE. It is necessary to take some interventions to avoid VTE.

  4. Dynamic changes and surveillance function of prion protein expression in gastric cancer drug resistance

    Institute of Scientific and Technical Information of China (English)

    Ji-Heng Wang; Jing-Ping Du; Ying-Hai Zhang; Xiao-Jun Zhao; Ru-Ying Fan; Zhi-Hong Wang; Zi-Tao Wu; Ying Han

    2011-01-01

    AIM: To explore the dynamic changes of prion protein (PrPc) in the process of gastric cancer drug resistance and the role of PrPc expression in the prognosis of gastric cancer patients receiving chemotherapy. METHODS: A series of gastric cancer cell lines resistant to different concentrations of adriamycin was established,and the expression of PrPc, Bcl-2 and Bax was detected in these cells. Apoptosis was determined using Annexin V staining. Western blotting and immunohistochemistry were performed to detect the expression of PrPc in patients receiving chemotherapy and to explore the role of PrPc expression in predicting the chemosensitivity and the outcome of gastric cancer patients receiving chemotherapy. Follow-up was performed for 2 years. RESULTS: PrPc expression was increased with the increase in drug resistance. Bcl-2, together with PrPc, increased the level of anti-apoptosis of cancer cells. Increased PrPc expression predicted the enhanced level of anti-apoptosis and resistance to anticancer drugs. PrPc expression could be used as a marker for predicting the efficacy of chemotherapy and the prognosis of gastric cancer. Increased PrPc expression predicted both poor chemosensitivity and a low 2-year survival rate. Contrarily, low PrPc expression predicted favorable chemosensitivity and a relatively high 2-year survival rate.CONCLUSION: PrPc expression is associated with histological types and differentiation of gastric cancer cells; The PrPc expression level might be a valuable marker in predicting the efficacy of chemotherapy and the prognosis of gastric cancer patients receiving chemotherapy.

  5. Monitoring of changes in lipid profiles during PLK1 knockdown in cancer cells using DESI MS.

    Science.gov (United States)

    Jayashree, Balasubramanyam; Srimany, Amitava; Jayaraman, Srinidhi; Bhutra, Anjali; Janakiraman, Narayanan; Chitipothu, Srujana; Krishnakumar, Subramanian; Baddireddi, Lakshmi Subhadra; Elchuri, Sailaja; Pradeep, Thalappil

    2016-08-01

    The importance of the polo-like kinase 1 (PLK1) gene is increasing substantially both as a biomarker and as a target for highly specific cancer therapy. This is due to its involvement in multiple points of cell progression and carcinogenesis. PLK1 inhibitors' efficacy in treating human cancers has been limited due to the lack of a specific targeting strategy. Here, we describe a method of targeted downregulation of PLK1 in cancer cells and the concomitant rapid detection of surface lipidomic perturbations using desorption electrospray ionization mass spectrometry (DESI MS). The efficient delivery of siRNA targeting PLK1 gene selectively to the cancer cells is achieved by targeting overexpressed cell surface epithelial cell adhesion molecule (EpCAM) by the EpDT3 aptamer. The chimeric aptamer (EpDT3-siPLK1) showed the knockdown of PLK1 gene expression and PLK1 protein levels by quantitative PCR and western blotting, respectively. The abundant surface lipids, phosphatidylcholines (PCs), such as PC(32:1) (m/z 754.6), PC(34:1) (m/z 782.6), and PC(36:2) (m/z 808.6), were highly expressed in MCF-7 and WERI-RB1 cancer cells compared to normal MIO-M1 cells and they were observed using DESI MS. These overexpressed cell surface lipids in the cancer cells were downregulated upon the treatment of EpDT3-siPLK1 chimera indicating a novel role of PLK1 to regulate surface lipid expression in addition to the efficient selective cancer targeting ability. Our results indicate that DESI MS has a potential ability to rapidly monitor aptamer-mediated cancer therapy and accelerate the drug discovery process. Graphical abstract Binding of aptamer chimera to the cells and changes in lipid profile. PMID:27277815

  6. A qualitative analysis of changes in relationship dynamics and roles between people with cancer and their primary informal carer.

    Science.gov (United States)

    Ussher, Jane M; Tim Wong, W K; Perz, Janette

    2011-11-01

    It is widely accepted that cancer is an intersubjective experience that impacts upon the psychological well-being of people with cancer and informal carers, as well as on couple relationships. This qualitative study examined the nature and consequences of cancer on the relationship between informal carers and the person with cancer, from the perspective of Australian cancer carers. Sixty-two carers (42 women and 20 men), across a range of cancer types, stages and relationship dyads took part in semi-structured interviews. Participants reported that cancer had precipitated a change in roles and in the dynamics of the relationship, including having to take on quasi-medical tasks and decisions, neglecting self and other relationships, changes to the emotions or personality of the person with cancer, changed patterns of communication, and changes to sexuality and intimacy. The impact of the changed relationship included sadness, anger and frustration, as well as feelings of love and being closer together, resulting in relationship enhancement. Women were more likely to report changes in the person with cancer and to mourn the previous relationship, while more men reported relationship enhancement.

  7. Quantifying the changes in survival inequality for Indigenous people diagnosed with cancer in Queensland, Australia.

    Science.gov (United States)

    Baade, Peter D; Dasgupta, Paramita; Dickman, Paul W; Cramb, Susanna; Williamson, John D; Condon, John R; Garvey, Gail

    2016-08-01

    The survival inequality faced by Indigenous Australians after a cancer diagnosis is well documented; what is less understood is whether this inequality has changed over time and what this means in terms of the impact a cancer diagnosis has on Indigenous people. Survival information for all patients identified as either Indigenous (n=3168) or non-Indigenous (n=211,615) and diagnosed in Queensland between 1997 and 2012 were obtained from the Queensland Cancer Registry, with mortality followed up to 31st December, 2013. Flexible parametric survival models were used to quantify changes in the cause-specific survival inequalities and the number of lives that might be saved if these inequalities were removed. Among Indigenous cancer patients, the 5-year cause-specific survival (adjusted by age, sex and broad cancer type) increased from 52.9% in 1997-2006 to 58.6% in 2007-2012, while it improved from 61.0% to 64.9% among non-Indigenous patients. This meant that the adjusted 5-year comparative survival ratio (Indigenous: non-Indigenous) increased from 0.87 [0.83-0.88] to 0.89 [0.87-0.93], with similar improvements in the 1-year comparative survival. Using a simulated cohort corresponding to the number and age-distribution of Indigenous people diagnosed with cancer in Queensland each year (n=300), based on the 1997-2006 cohort mortality rates, 35 of the 170 deaths due to cancer (21%) expected within five years of diagnosis were due to the Indigenous: non-Indigenous survival inequality. This percentage was similar when applying 2007-2012 cohort mortality rates (19%; 27 out of 140 deaths). Indigenous people diagnosed with cancer still face a poorer survival outlook than their non-Indigenous counterparts, particularly in the first year after diagnosis. The improving survival outcomes among both Indigenous and non-Indigenous cancer patients, and the decreasing absolute impact of the Indigenous survival disadvantage, should provide increased motivation to continue and enhance

  8. Seasonal changes in serum melatonin in women with previous breast cancer.

    OpenAIRE

    Holdaway, I. M.; Mason, B. H.; Gibbs, E. E.; Rajasoorya, C.; Hopkins, K.D.

    1991-01-01

    A seasonal variation in the month of initial detection of breast cancer has been previously observed in pre-menopausal women, and it has been proposed that this may be due to cyclic changes in tumour growth mediated by the effects of melatonin on ovarian function. To investigate this possibility serum melatonin concentrations have been measured every 2 h for 24 h at the summer and winter solstice in 20 pre-menopausal women with previous breast cancer and nine controls. Twelve women had detect...

  9. Antiscience and ethical concerns associated with advocacy of Lyme disease.

    Science.gov (United States)

    Auwaerter, Paul G; Bakken, Johan S; Dattwyler, Raymond J; Dumler, J Stephen; Halperin, John J; McSweegan, Edward; Nadelman, Robert B; O'Connell, Susan; Shapiro, Eugene D; Sood, Sunil K; Steere, Allen C; Weinstein, Arthur; Wormser, Gary P

    2011-09-01

    Advocacy for Lyme disease has become an increasingly important part of an antiscience movement that denies both the viral cause of AIDS and the benefits of vaccines and that supports unproven (sometimes dangerous) alternative medical treatments. Some activists portray Lyme disease, a geographically limited tick-borne infection, as a disease that is insidious, ubiquitous, difficult to diagnose, and almost incurable; they also propose that the disease causes mainly non-specific symptoms that can be treated only with long-term antibiotics and other unorthodox and unvalidated treatments. Similar to other antiscience groups, these advocates have created a pseudoscientific and alternative selection of practitioners, research, and publications and have coordinated public protests, accused opponents of both corruption and conspiracy, and spurred legislative efforts to subvert evidence-based medicine and peer-reviewed science. The relations and actions of some activists, medical practitioners, and commercial bodies involved in Lyme disease advocacy pose a threat to public health.

  10. Patient advocacy groups: Need and opportunity in India

    Directory of Open Access Journals (Sweden)

    Kunal Shah

    2011-01-01

    Full Text Available With an increasing number of corporate hospitals, healthcare related issues, research trials and undue attention by media in India, there is a need to focus more on patient′s rights and protection. In India, multiple agencies like regulatory bodies, scientific review committees, ethics committees, NGOs, etc. work toward patient rights and protection. However, these agencies are inadequate to cater to the general issues related to patient′s rights. There′s a need to have a separate group of people who provide advocacy to the patient, or simply, a patient advocacy group which will work explicitly in these areas to increase transparency and credibility of healthcare system in India. This group will provide special attention to patient care and protection of rights from the planning stage rather than at the troubleshooting stage.

  11. Nursing Actions in practicing inpatient advocacy in a Burn Unit

    Directory of Open Access Journals (Sweden)

    Aline Carniato Dalle Nogario

    2015-08-01

    Full Text Available OBJECTIVEUnderstanding nursing actions in the practice of inpatient advocacy in a burn unit.METHODA single and descriptive case study, carried out with nurses working in a referral burn center in southern Brazil. Data were collected through focus group technique, between February and March 2014, in three meetings. Data was analysed through discursive textual analysis.RESULTSThree emerging categories were identified, namely: (1 instructing the patient; (2 protecting the patient; and (3 ensuring the quality of care.CONCLUSIONSThis study identified that the nurses investigated exercised patient advocacy and that the recognition of their actions is an advance for the profession, contributing to the autonomy of nurses and the effectiveness of patients' rights and social justice.

  12. The Social Work Reinvestment Initiative: advocacy and social work practice.

    Science.gov (United States)

    Talbot, Elizabeth Peffer; McMillin, Joan A

    2014-07-01

    In 2006, NASW launched the Social Work Reinvestment Initiative by granting each state chapter $15,000 in seed money to address the most pressing social work needs in the state. This article describes how NASW-SD, with 246 members, launched an epic campaign that resulted in the establishment of the only MSW program in South Dakota. Using historical research methods, this article demonstrates the power of social work advocacy when members unify in pursuit of a common goal and describes how the social workers rallied to educate policymakers and the public on the value of social work and its delivery of necessary social services at all levels and in all fields of practice. The research highlights an uphill battle of advocacy and the skillful planning and implementation of a campaign to secure state funding to establish the first MSW program in the state, at the beginning of the most difficult economic recession since the Great Depression.

  13. Sodium butyrate-induced apoptosis and ultrastructural changes in MCF-7 breast cancer cells.

    Science.gov (United States)

    Wang, Ying; Hu, Peng-Chao; Ma, Yan-Bin; Fan, Rong; Gao, Fang-Fang; Zhang, Jing-Wei; Wei, Lei

    2016-01-01

    This study investigated the effects of sodium butyrate (NaB) on Michigan Cancer Foundation-7 (MCF-7) breast cancer cells and analyzed the relevant mechanism. Here, we demonstrated that a certain concentration of NaB effectively induced MCF-7 cell apoptosis. Cell counting kit-8 (CCK-8) assay was used to detect cell viability and the apoptosis rate. Western blotting was used to detect changes in the Bcl-2 expression level. We observed cell shape changes with microscopy. Immunofluorescence revealed some apoptotic nuclei. Electron microscopy revealed thick nucleoli, chromatin margination, reduced mitochondria, and dramatic vacuoles. Collectively, our findings elucidated the morphological mechanism by which NaB changed the ultrastructure of MCF-7 cells.

  14. Training self-advocacy skills to adults with mild handicaps.

    OpenAIRE

    Sievert, A L; Cuvo, A J; Davis, P K

    1988-01-01

    We developed and empirically evaluated an instructional program to teach self-advocacy skills to eight young adults with mild handicaps. Participants were taught to discriminate whether or not possible violations of legal rights occurred in socially validated scenarios and, if so, to role-play how to redress rights violations. Experimental control was demonstrated with a multiple probe design across four general legal rights categories for the discrimination component of training, and a multi...

  15. Ethics and the choice of animal advocacy campaigns

    OpenAIRE

    Waters, James

    2014-01-01

    This paper examines how different ethical positions view various types of animal advocacy campaigns concerning a product produced using animals. The ethical positions represent common company, social, and animal advocate viewpoints. Working in a market model with a monopolistic supplier, we determine whether the ethical positions support or oppose each campaign, and in what conditions. We describe three easily implemented campaign strategies that combine animal welfare and rights goals.

  16. Changes in MR imaging appearance of breast cancer after intra-arterial infusion chemotherapy

    International Nuclear Information System (INIS)

    The purpose of this study was to evaluate whether the characteristic change in breast cancer related to chemotherapeutic response (CR) and the effect of invasion and toxicity in the skin and pectoralis muscle exist on MR imaging after intra-arterial infusion chemotherapy. A total of 11 patients with histologically proven breast cancer underwent MR study before and after chemotherapy. Changes in images and the dynamic curveafter-chemotherapy were evaluated, including time to maximum signal intensity (SI) and the early phase enhance ratio (EPER) in the tumor. In the tumor, changes in the dynamic curve, time to maximum SI, EPER and necrosis did not correlate with CR, but change in SI on T2-weighted images was suggested to do so. Changes in the dynamic curve and images in the pectoralis muscle and in images on the skin were suggested to correlate with CR. In addition, images changed for the worse in many cases of invasion and toxicity in the pectoralis muscle and in some cases of invasion in the skin. In conclusion, tumors had fewer imaging changes correlating with CR after intra-arterial infusion chemotherapy. Changes for the worse in images of the pectoralis muscle and skin may be useful for the evaluation of invasion. (author)

  17. To assess the effects of nutritional intervention based on advocacy approach on malnutrition status among school-aged children in Shiraz

    Directory of Open Access Journals (Sweden)

    Hassan Joulaei

    2013-01-01

    Full Text Available Background: The present study was carried out to assess the effects of community nutrition intervention based on advocacy approach on malnutrition status among school-aged children in Shiraz, Iran. Materials and Methods: This case-control nutritional intervention has been done between 2008 and 2009 on 2897 primary and secondary school boys and girls (7-13 years old based on advocacy approach in Shiraz, Iran. The project provided nutritious snacks in public schools over a 2-year period along with advocacy oriented actions in order to implement and promote nutritional intervention. For evaluation of effectiveness of the intervention growth monitoring indices of pre- and post-intervention were statistically compared. Results: The frequency of subjects with body mass index lower than 5% decreased significantly after intervention among girls (P = 0.02. However, there were no significant changes among boys or total population. The mean of all anthropometric indices changed significantly after intervention both among girls and boys as well as in total population. The pre- and post-test education assessment in both groups showed that the student′s average knowledge score has been significantly increased from 12.5 ± 3.2 to 16.8 ± 4.3 (P < 0.0001. Conclusion: This study demonstrates the potential success and scalability of school feeding programs in Iran. Community nutrition intervention based on the advocacy process model is effective on reducing the prevalence of underweight specifically among female school aged children.

  18. Changes of histology and expression of MMP-2 and nm23-H1 in primary and metastatic gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Lin-Bo Wang; Zhi-Nong Jiang; Miao-Ying Fan; Chao-Yang Xu; Wen-Jun Chen; Jian-Guo Shen

    2008-01-01

    AIM:To investigate the changes of histology and expression of MMP-2 and nm23-H1 in primary and metastatic gastric cancer.METHODS:One hundred and seventy-seven gastric cancer patients with lymph node and/or distal metastasis between 1997 and 2001 were reviewed.Differences in histology of the primary and metastatic gastric cancer were assessed.MMP-2 and nm23-H1 immunoreactivity was compared in 44 patients with tumor infiltration to the serosa layer.RESULTS:Poorly and moderately differentiated metastatic gastric cancer was found in 88.7% (157/177)and primary gastric cancer in 75.7% (134/177) of the patients.The histological type of metastatic gastric cancer that was not completely in accordance with the preponderant histology of primary gastric cancer was observed in 25 patients (14.1%).MMP-2 immunoreactivity in metastatic gastric cancer was significantly stronger than that in primary gastric cancer,while nm23-H1 immunoreactivity showed no difference in primary and metastatic gastric cancer.CONCLUSION:Metastatic gastric cancer presents more aggressive histological morphology and higher MMP-2 immunoreactivity than primary gastric cancer.This heterogeneity may elicit a possible mechanism of gastric cancer metastasis.

  19. Rivalry of Advocacy Coalitions in the Czech Pension Reform

    Directory of Open Access Journals (Sweden)

    Potůček Martin

    2016-06-01

    Full Text Available The Czech Republic, as many other countries of Central and Eastern Europe, faced and is still facing a pension-reform challenge. The diversification of pension pillars led to the massive displacements of participant contributions from the public PAYG pension pillars to the newly constructed private, defined-contribution, fully-funded pillars. In the Czech Republic, the adoption of the relevant law was preceded by serious political conflict between supporters and opponents of this step (both among different political actors and among professionals. In an analysis of the conflict we critically apply the Advocacy Coalition Framework. We work mainly with the analysis of policy documents, public statements of the individual actors and an analysis of voting on the relevant law in both chambers of the Czech Parliament towards the identification of the crystallization process of two clear-cut coalitions between actors from both sides of the spectrum. The Advocacy Coalition Framework in exploring the dynamics of the public-policy process proved to be able to explain situations where there is sharp political conflict. Through the lens of the devil-shift of both camps (advocacy coalitions with different beliefs, each fell into extreme positions within the coalition to affirm the correctness of their arguments and positions.

  20. Changing paradigm of cancer therapy:precision medicine by next-generation sequencing

    Institute of Scientific and Technical Information of China (English)

    Yuan Xue; William R Wilcox

    2016-01-01

    Precision medicine aims to identify the right drug, for the right patient, at the right dose, at the right time, which is particularly important in cancer therapy. Problems such as the variability of treatment response and resistance to medication have been long-standing challenges in oncology, especially for development of new medications. Solid tumors, unlike hematologic malignancies or brain tumors, are remarkably diverse in their cellular origins and developmental timing. The ability of next-generation sequencing (NGS) to analyze the comprehensive landscape of genetic alterations brings promises to diseases that have a highly complex and heterogeneous genetic composition such as cancer. Here we provide an overview of how NGS is able to facilitate precision medicine and change the paradigm of cancer therapy, especially for solid tumors, through technical advancements, molecular diagnosis, response monitoring and clinical trials.

  1. Changing paradigm of cancer therapy: precision medicine by next-generation sequencing

    Science.gov (United States)

    Xue, Yuan; Wilcox, William R.

    2016-01-01

    Precision medicine aims to identify the right drug, for the right patient, at the right dose, at the right time, which is particularly important in cancer therapy. Problems such as the variability of treatment response and resistance to medication have been long-standing challenges in oncology, especially for development of new medications. Solid tumors, unlike hematologic malignancies or brain tumors, are remarkably diverse in their cellular origins and developmental timing. The ability of next-generation sequencing (NGS) to analyze the comprehensive landscape of genetic alterations brings promises to diseases that have a highly complex and heterogeneous genetic composition such as cancer. Here we provide an overview of how NGS is able to facilitate precision medicine and change the paradigm of cancer therapy, especially for solid tumors, through technical advancements, molecular diagnosis, response monitoring and clinical trials. PMID:27144059

  2. Predicting Levels of Policy Advocacy Engagement Among Acute-Care Health Professionals.

    Science.gov (United States)

    Jansson, Bruce S; Nyamathi, Adeline; Heidemann, Gretchen; Bird, Melissa; Ward, Cathy Rogers; Brown-Saltzman, Katherine; Duan, Lei; Kaplan, Charles

    2016-02-01

    This study aims to describe the factors that predict health professionals' engagement in policy advocacy. The researchers used a cross-sectional research design with a sample of 97 nurses, 94 social workers, and 104 medical residents from eight hospitals in Los Angeles. Bivariate correlations explored whether seven predictor scales were associated with health professionals' policy advocacy engagement and revealed that five of the eight factors were significantly associated with it (p engagement, eagerness, skills, tangible support, and organizational receptivity. Regression analysis examined whether the seven scales, when controlling for sociodemographic variables and hospital site, predicted levels of policy advocacy engagement. Results revealed that patient advocacy engagement (p engagement. Ethical commitment did not predict policy advocacy engagement. The model explained 36% of the variance in policy advocacy engagement. Limitations of the study and its implications for future research, practice, and policy are discussed. PMID:27151835

  3. Changes in Initial Treatment for Prostate Cancer Among Medicare Beneficiaries, 1999–2007

    International Nuclear Information System (INIS)

    Purpose: In the absence of evidence from large clinical trials, optimal therapy for localized prostate cancer remains unclear; however, treatment patterns continue to change. We examined changes in the management of patients with prostate cancer in the Medicare population. Methods and Materials: We conducted a retrospective claims-based analysis of the use of radiation therapy, surgery, and androgen deprivation therapy in the 12 months after diagnosis of prostate cancer in a nationally representative 5% sample of Medicare claims. Patients were Medicare beneficiaries 67 years or older with incident prostate cancer diagnosed between 1999 and 2007. Results: There were 20,918 incident cases of prostate cancer between 1999 and 2007. The proportion of patients receiving androgen deprivation therapy decreased from 55% to 36%, and the proportion of patients receiving no active therapy increased from 16% to 23%. Intensity-modulated radiation therapy replaced three-dimensional conformal radiation therapy as the most common method of radiation therapy, accounting for 77% of external beam radiotherapy by 2007. Minimally invasive radical prostatectomy began to replace open surgical approaches, being used in 49% of radical prostatectomies by 2007. Conclusions: Between 2002 and 2007, the use of androgen deprivation therapy decreased, open surgical approaches were largely replaced by minimally invasive radical prostatectomy, and intensity-modulated radiation therapy replaced three-dimensional conformal radiation therapy as the predominant method of radiation therapy in the Medicare population. The aging of the population and the increasing use of newer, higher-cost technologies in the treatment of patients with prostate cancer may have important implications for nationwide health care costs.

  4. Changes in Initial Treatment for Prostate Cancer Among Medicare Beneficiaries, 1999-2007

    Energy Technology Data Exchange (ETDEWEB)

    Dinan, Michaela A.; Robinson, Timothy J. [Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (United States); Zagar, Timothy M. [Department of Radiation Oncology, Duke University School of Medicine, Durham, NC (United States); Scales, Charles D. [Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (United States); Department of Surgery, Duke University School of Medicine, Durham, NC (United States); Curtis, Lesley H.; Reed, Shelby D. [Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (United States); Department of Medicine, Duke University School of Medicine, Durham, NC (United States); Lee, W. Robert [Department of Radiation Oncology, Duke University School of Medicine, Durham, NC (United States); Schulman, Kevin A., E-mail: kevin.schulman@duke.edu [Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (United States); Department of Medicine, Duke University School of Medicine, Durham, NC (United States)

    2012-04-01

    Purpose: In the absence of evidence from large clinical trials, optimal therapy for localized prostate cancer remains unclear; however, treatment patterns continue to change. We examined changes in the management of patients with prostate cancer in the Medicare population. Methods and Materials: We conducted a retrospective claims-based analysis of the use of radiation therapy, surgery, and androgen deprivation therapy in the 12 months after diagnosis of prostate cancer in a nationally representative 5% sample of Medicare claims. Patients were Medicare beneficiaries 67 years or older with incident prostate cancer diagnosed between 1999 and 2007. Results: There were 20,918 incident cases of prostate cancer between 1999 and 2007. The proportion of patients receiving androgen deprivation therapy decreased from 55% to 36%, and the proportion of patients receiving no active therapy increased from 16% to 23%. Intensity-modulated radiation therapy replaced three-dimensional conformal radiation therapy as the most common method of radiation therapy, accounting for 77% of external beam radiotherapy by 2007. Minimally invasive radical prostatectomy began to replace open surgical approaches, being used in 49% of radical prostatectomies by 2007. Conclusions: Between 2002 and 2007, the use of androgen deprivation therapy decreased, open surgical approaches were largely replaced by minimally invasive radical prostatectomy, and intensity-modulated radiation therapy replaced three-dimensional conformal radiation therapy as the predominant method of radiation therapy in the Medicare population. The aging of the population and the increasing use of newer, higher-cost technologies in the treatment of patients with prostate cancer may have important implications for nationwide health care costs.

  5. Epigenetics changes caused by the fusion of human embryonic stem cell and ovarian cancer cells.

    Science.gov (United States)

    He, Ke; Qu, Hu; Xu, Li-Nan; Gao, Jun; Cheng, Fu-Yi; Xiang, Peng; Zhou, Can-Quan

    2016-10-01

    To observe the effect of gene expression and tumorigenicity in hybrid cells of human embryonic stem cells (hESCs) and ovarian cancer cells in vitro and in vivo using a mouse model, and to determine its feasibility in reprogramming tumour cells growth and apoptosis, for a potential exploration of the role of hESCs and tumour cells fusion in the management of ovarian cancer. Stable transgenic hESCs (H1) and ovarian cancer cell line OVCAR-3 were established before fusion, and cell fusion system was established to analyse the related indicators. PTEN expression in HO-H1 cells was higher than those in the parental stem cells and lower than those in parental tumour cells; the growth of OV-H1 (RFP+GFP) hybrid cells with double fluorescence expressions were obviously slower than that of human embryonic stem cells and OVCAR-3 ovarian cancer cells. The apoptosis signal of the OV-H1 hybrid cells was significantly higher than that of the hESCs and OVCAR-3 ovarian cancer cells. In vivo results showed that compared with 7 days, 28 days and 35 days after inoculation of OV-H1 hybrid cells; also, apoptotic cell detection indicated that much stronger apoptotic signal was found in OV-H1 hybrid cells inoculated mouse. The hESCs can inhibit the growth of OVCAR-3 cells in vitro by suppressing p53 and PTEN expression to suppress the growth of tumour that may be achieved by inducing apoptosis of OVCAR-3 cells. The change of epigenetics after fusion of ovarian cancer cells and hESCs may become a novel direction for treatment of ovarian cancer.

  6. Epigenetics changes caused by the fusion of human embryonic stem cell and ovarian cancer cells

    Science.gov (United States)

    He, Ke; Qu, Hu; Xu, Li-Nan; Gao, Jun; Cheng, Fu-Yi; Xiang, Peng; Zhou, Can-Quan

    2016-01-01

    To observe the effect of gene expression and tumorigenicity in hybrid cells of human embryonic stem cells (hESCs) and ovarian cancer cells in vitro and in vivo using a mouse model, and to determine its feasibility in reprogramming tumour cells growth and apoptosis, for a potential exploration of the role of hESCs and tumour cells fusion in the management of ovarian cancer. Stable transgenic hESCs (H1) and ovarian cancer cell line OVCAR-3 were established before fusion, and cell fusion system was established to analyse the related indicators. PTEN expression in HO-H1 cells was higher than those in the parental stem cells and lower than those in parental tumour cells; the growth of OV-H1 (RFP+GFP) hybrid cells with double fluorescence expressions were obviously slower than that of human embryonic stem cells and OVCAR-3 ovarian cancer cells. The apoptosis signal of the OV-H1 hybrid cells was significantly higher than that of the hESCs and OVCAR-3 ovarian cancer cells. In vivo results showed that compared with 7 days, 28 days and 35 days after inoculation of OV-H1 hybrid cells; also, apoptotic cell detection indicated that much stronger apoptotic signal was found in OV-H1 hybrid cells inoculated mouse. The hESCs can inhibit the growth of OVCAR-3 cells in vitro by suppressing p53 and PTEN expression to suppress the growth of tumour that may be achieved by inducing apoptosis of OVCAR-3 cells. The change of epigenetics after fusion of ovarian cancer cells and hESCs may become a novel direction for treatment of ovarian cancer. PMID:27377320

  7. Patient Derived Cancer Cell Lines in Identifying Molecular Changes in Patients With Previously Untreated Pancreatic Cancer Receiving Gemcitabine Hydrochloride-Based Chemotherapy

    Science.gov (United States)

    2016-10-18

    Pancreatic Ductal Adenocarcinoma; Stage IA Pancreatic Cancer; Stage IB Pancreatic Cancer; Stage IIA Pancreatic Cancer; Stage IIB Pancreatic Cancer; Stage III Pancreatic Cancer; Stage IV Pancreatic Cancer

  8. Changes in body composition of cancer patients following combined nutritional support

    International Nuclear Information System (INIS)

    The effects of combined nutritional support (parenteral, enteral, and oral) were measured in cancer patients unable to maintain normal alimentation.Changes in body composition were quantified by measurement of total body levels of nitrogen, potassium, water, and fat. The protein-calorie intake of the patients was also evaluated by dietary survey (4-day recall). Standard anthropometric and biochemical measurements for nutritional assessment were obtained for comparison. The dietary evaluation indicated that the dietary supplementation for all patients was more than adequate to meet their energy requirements. Determination of body composition indicated that change in body weight was equal to the sum of the changes in body protein, total body water, and total body fat. Information on the nature of the tissue gained was obtained by comparison of body composition data with the ratio of protein:water:lean body mass for normal tissue. The mean gain of protein in the cancer patients was quite small (0.3-0.6 kg). The main change in body weight appeared to be the result of gains in body water and body fat. The total body nitrogen to potassium ratio served to define the extent of tissue anabolism following hyperalimentation. The ratio dropped in the cancer patients following hyperalimentation toward the value of the control subjects on ad libitum diets. Total body nitrogen was determined by prompt gamma neutron activation analysis, total body potassium by whole-body counting

  9. Development and Psychometric Evaluation of the Instrument: Attitudes Towards Organ Donor Advocacy Scale (ATODAS)

    OpenAIRE

    Flodén, Anne; Lennerling, Annette; Fridh, Isabell; Rizell, Magnus; Forsberg, Anna

    2011-01-01

    The consequences of advocacy in nursing are critical when caring for a potential organ donor. No specific instrument has been available to measure attitudes toward organ donor advocacy. The aim of this study was to develop and psychometrically evaluate an instrument for measuring intensive and critical care (ICU) nurses’ attitudes toward organ donor advocacy. The study was conducted in two stages: instrument development and instrument evaluation and refinement. A questionnaire was developed (...

  10. Assessment of tobacco control advocacy behavioural capacity among students at schools of public health in China

    OpenAIRE

    Yang, Tingzhong; Abdullah, Abu S.; Rockett, Ian R. H.; Li, Mu; Zhou, Yuhua; Jun MA; Ji, Huaping; Zheng, Jianzhong; Zhang, Yuhong; Wang, Liming

    2010-01-01

    Objectives To evaluate student tobacco control advocacy behavioural capacity using longitudinal trace data. Methods A tobacco control advocacy curriculum was developed and implemented at schools of public health (SPH) or departments of public health in seven universities in China. Participants comprised undergraduate students studying the public health curriculum in these 13 Universities. A standardised assessment tool was used to evaluate their tobacco control advocacy behavioural capacity. ...

  11. Epigenetic changes of pituitarytumor-derived transforming gene 1 in pancreatic cancer

    Institute of Scientific and Technical Information of China (English)

    Mang-Li Zhang; Sen Lu; Shu-Sen Zheng

    2008-01-01

    BACKGROUND: Pancreatic cancer is a devastating disease with abnormal genetic changes. The pituitary tumor-derived transforming gene (PTTG) is considered to be implicated in the tumorigenesis of cancers when the gene is epigenetically transformed. In this study, we investigated the relationships between aberrant expression and epigenetic changes of the PTTG1 gene in pancreatic cancer. METHODS: We chose 4 cell lines (PANC-1, Colo357, T3M-4 and PancTuⅠ) and pancreatic ductal adenocarcinoma (PDAC) tissues. After using restriction isoschizomer endonucleases (MspⅠ/HpaⅡ) to digest the DNA sequence (5'-CCGG-3'), we performed PCR reaction to amplify the product. And RT-PCR was applied to determine the gene expression. RESULTS: The mRNA expression of the PTTG1 gene was higher in pancreatic tumor than in normal tissue. The gene was also expressed in the 4 PDAC cell lines. The methylation states of the upstream regions of the PTTG1 gene were almost identical in normal, tumor pancreatic tissues and the 4 PDAC cell lines. Some (5'-CCGG-3') areas in the upstream region of PTTG1 were methylated, while some others were unmethylated. CONCLUSIONS: The oncogene PTTG1 was overexpressed in pancreatic tumor tissues and veriifed by RT-PCR detection. The methylation status of DNA in promoter areas was involved in the gene expression with the help of other factors in pancreatic cancer.

  12. Risk for colorectal cancer in ulcerative colitis: Changes, causes and management strategies

    Institute of Scientific and Technical Information of China (English)

    Peter Laszlo Lakatos; Laszlo Lakatos

    2008-01-01

    The risk of colorectal cancer for any patient with ulcerative colitis is known to be elevated, and is estimated to be 2% after 10 years, 8% after 20 years and 18% after 30 years of disease. Risk factors for cancer include extent and duration of ulcerative colitis, primary sclerosing cholangitis, a family history of sporadic colorectal cancer, severity of histologic bowel inflammation, and in some studies, young age at onset of colitis. In this review, the authors discuss recent epidemiological trends and causes for the observed changes. Population-based studies published within the past 5 years suggest that this risk has decreased over time, despite the low frequency of colectomies. The crude annual incidence rate of colorectal cancer in ulcerative colitis ranges from approximately 0.06% to 0.16% with a relative risk of 1.0-2.75. The exact mechanism for this change is unknown; it may partly be explained by the more widespread use of maintenance therapy and surveillance colonoscopy.

  13. Advocacy Priorities and Strategies for ASAHP: A Survey of the ASAHP Membership.

    Science.gov (United States)

    Fry, Donna; Demo, David H; Devine, Nancy; Butler, Andrew; Saladin, Lisa

    2015-01-01

    The Association of Schools of Allied Health Professions (ASAHP) recently established a strategic goal to increase advocacy efforts. The purpose of this study was to identify advocacy priorities and preferred advocacy strategies among the ASAHP membership. A brief Advocacy Priorities and Strategies Survey was sent to 234 ASAHP members included in the ASAHP email list using an online survey software. Forty-eight members (20%) completed the survey. Data were analyzed using the online survey software and response frequency counts. ASAHP members identified the following federal advocacy priorities: 1) support for students entering allied health professions, 2) support for faculty seeking higher degrees to enhance quality of education in allied health programs, 3) support for higher education institutions to increase capacity of professional programs to address projected allied health workforce needs identified by the Bureau of Labor Statistics, and 4) support for research funding from federal agencies for allied health. The need for education regarding allied health professions to enhance advocacy efforts was also reported. Preferred advocacy strategies included scheduling ASAHP conferences in Washington, DC, to facilitate trips to Capitol Hill and visiting legislators in home states. Members also indicated a need to participate in advocacy training to enhance their advocacy skills.

  14. Promoting Sex and Reproductive Health Education among Adolescent Should Place Emphasis on Advocacy

    Institute of Scientific and Technical Information of China (English)

    Yong-liang LIU; Jin WANG

    2006-01-01

    Objective To make a exploration of the function of advocacy in the promotion of sex and reproductive health education for adolescents.Methods The advocacy played a key role on the promotion of adolescent sex and reproductive education by taking "International cooperation project to promote Chinese youth reproductive health "(YRH project) as example.Results The successful experience of YRH project indicated advocacy's important function in the promotion of sex and reproductive health education for adolescents.Conclusion Advocacy is a crucial element in promoting adolescent sex and reproductive health education.

  15. Advocacy Interventions to Reduce or Eliminate Violence and Promote the Physical and Psychosocial Wellbeing of Women Who Experience Intimate Partner Abuse: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Rivas, C

    2016-01-01

    had considerable clinical heterogeneity in relation to staff delivering advocacy; setting (community, shelter, antenatal, healthcare; advocacy intensity (from 30 minutes to 80 hours; and abuse severity. Three trials evaluated advocacy within multi-component interventions. Eleven measured some form of abuse (eight scales, six assessed quality of life (three scales, and six measured depression (three scales. Countries and ethnic groups varied (one or more minority ethnic groups in the USA or UK, and local populations in Hong Kong and Peru. Setting was associated with intensity and duration of advocacy. Risk of bias was high in five studies, moderate in five, and low in three. The quality of evidence (considering multiple factors such as risk of bias, study size, missing data was moderate to low for brief advocacy and very low for intensive advocacy. Incidence of abuse Physical abuse Moderate quality pooled data from two healthcare studies (moderate risk of bias and one community study (low risk of bias, all with 12-month follow-up data, showed no effect on physical abuse for brief (< 12 hours advocacy interventions (standardised mean difference (SMD 0.00, 95% confidence interval (CI - 0.17 to 0.16; n = 558. One antenatal study (low risk of bias showed an association between brief advocacy and reduced minor physical abuse at one year (mean difference (MD change - 1.00, 95% CI - 1.82 to - 0.18; n = 110. An antenatal, multi-component study showed a greater likelihood of physical abuse ending (odds ratio (OR 0.42, 95% CI 0.23 to 0.75 immediately after advocacy (number needed to treat (NNT = 8; we cannot exclude impact from other components. Low to very low quality evidence from two intensive advocacy trials (12 hours plus duration showed reduced severe physical abuse in women leaving a shelter at 24 months (OR 0.39, 95% CI 0.20 to 0.77; NNT = 8, but not at 12 or 36 months. Sexual abuse Meta-analysis of two studies (n = 239 showed no effect of advocacy on sexual abuse (SMD

  16. Changes in cytoskeletal dynamics and nonlinear rheology with metastatic ability in cancer cell lines

    International Nuclear Information System (INIS)

    Metastatic outcome is impacted by the biophysical state of the primary tumor cell. To determine if changes in cancer cell biophysical properties facilitate metastasis, we quantified cytoskeletal biophysics in well-characterized human skin, bladder, prostate and kidney cell line pairs that differ in metastatic ability. Using magnetic twisting cytometry with optical detection, cytoskeletal dynamics was observed through spontaneous motion of surface bound marker beads and nonlinear rheology was characterized through large amplitude forced oscillations of probe beads. Measurements of cytoskeletal dynamics and nonlinear rheology differed between strongly and weakly metastatic cells. However, no set of biophysical parameters changed systematically with metastatic ability across all cell lines. Compared to their weakly metastatic counterparts, the strongly metastatic kidney cancer cells exhibited both increased cytoskeletal dynamics and stiffness at large deformation which are thought to facilitate the process of vascular invasion. (paper)

  17. Residence, income and cancer hospitalizations in British Columbia during a decade of policy change

    Directory of Open Access Journals (Sweden)

    Penning MJ

    2004-04-01

    Full Text Available Abstract Background Through the 1990s, governments across Canada shifted health care funding allocation and organizational foci toward a community-based population health model. Major concerns of reform based on this model include ensuring equitable access to health and health care, and enhancing preventive and community-based resources for care. Reforms may act differentially relative to specific conditions and services, including those geared to chronic versus acute conditions. The present study therefore focuses on health service utilization, specifically cancer hospitalizations, in British Columbia during a decade of health system reform. Methods Data were drawn from the British Columbia Linked Health Data resource; income measures were derived from Statistics Canada 1996 Census public use enumeration area income files. Records with a discharge (separation date between 1 January 1991 and 31 December 1998 were selected. All hospitalizations with ICD-9 codes 140 through 208 (except skin cancer, code 173 as principal diagnosis were included. Specific cancers analyzed include lung; colorectal; female breast; and prostate. Hospitalizations were examined in total (all separations, and as divided into first and all other hospitalizations attributed to any given individual. Annual trends in age-sex adjusted rates were analyzed by joinpoint regression; longitudinal multivariate analyses assessing association of residence and income with hospitalizations utilized generalised estimating equations. Results are evaluated in relation to cancer incidence trends, health policy reform and access to care. Results Age-sex adjusted hospitalization rates for all separations for all cancers, and lung, breast and prostate cancers, decreased significantly over the study period; colorectal cancer separations did not change significantly. Rates for first and other hospitalizations remained stationary or gradually declined over the study period. Area of residence and

  18. Effect of recent changes in atomic bomb survivor dosimetry on cancer mortality risk estimates.

    Science.gov (United States)

    Preston, Dale L; Pierce, Donald A; Shimizu, Yukiko; Cullings, Harry M; Fujita, Shoichiro; Funamoto, Sachiyo; Kodama, Kazunori

    2004-10-01

    The Radiation Effects Research Foundation has recently implemented a new dosimetry system, DS02, to replace the previous system, DS86. This paper assesses the effect of the change on risk estimates for radiation-related solid cancer and leukemia mortality. The changes in dose estimates were smaller than many had anticipated, with the primary systematic change being an increase of about 10% in gamma-ray estimates for both cities. In particular, an anticipated large increase of the neutron component in Hiroshima for low-dose survivors did not materialize. However, DS02 improves on DS86 in many details, including the specifics of the radiation released by the bombs and the effects of shielding by structures and terrain. The data used here extend the last reported follow-up for solid cancers by 3 years, with a total of 10,085 deaths, and extends the follow-up for leukemia by 10 years, with a total of 296 deaths. For both solid cancer and leukemia, estimated age-time patterns and sex difference are virtually unchanged by the dosimetry revision. The estimates of solid-cancer radiation risk per sievert and the curvilinear dose response for leukemia are both decreased by about 8% by the dosimetry revision, due to the increase in the gamma-ray dose estimates. The apparent shape of the dose response is virtually unchanged by the dosimetry revision, but for solid cancers, the additional 3 years of follow-up has some effect. In particular, there is for the first time a statistically significant upward curvature for solid cancer on the restricted dose range 0-2 Sv. However, the low-dose slope of a linear-quadratic fit to that dose range should probably not be relied on for risk estimation, since that is substantially smaller than the linear slopes on ranges 0-1 Sv, 0-0.5 Sv, and 0- 0.25 Sv. Although it was anticipated that the new dosimetry system might reduce some apparent dose overestimates for Nagasaki factory workers, this did not materialize, and factory workers have

  19. Body composition changes in females treated for breast cancer: a review of the evidence.

    Science.gov (United States)

    Sheean, Patricia M; Hoskins, Kent; Stolley, Melinda

    2012-10-01

    Body composition changes cannot be precisely captured using body weight or body mass index measures. Therefore, the primary purpose of this review was to characterize the patterns of body composition change in females treated for breast cancer including only studies that utilize imaging technologies to quantify adipose tissue and lean body mass (LBM). We reviewed PubMed for studies published between 1971 and 2012 involving females diagnosed with breast cancer where computed axial tomography , dual-energy X-ray absorptiometry, or magnetic resonance imaging were employed for body composition assessment. Of the initial 440 studies, 106 papers were evaluated and 36 papers met all eligibility criteria (15 observational and 21 intervention trials). Results of these studies revealed that body weight did not consistently increase. Importantly, studies also showed that body weight did not accurately depict changes in lean or adipose tissues. Further findings included that sarcopenic obesity as a consequence of breast cancer treatment was not definitive, as menopausal status may be a substantial moderator of body composition. Overall, the behavioral interventions did not exhibit consistent or profound effects on body composition outcomes; approximately half showed favorable influence on adiposity while the effects on LBM were not apparent. The use of tamoxifen had a clear negative impact on body composition. The majority of studies were conducted in predominantly white survivors, highlighting the need for trials in minority populations. Collectively, these studies were limited by age, race, and/or menopause status matched control groups, overall size, and statistical power. Very few studies simultaneously collected diet and exercise data-two potential factors that impact body composition. Future breast cancer trials should prioritize precise body composition methodologies to elucidate how these changes impact recurrence, prognosis, and mortality, and to provide clinicians

  20. Neural Changes following Behavioral Activation for a Depressed Breast Cancer Patient: A Functional MRI Case Study

    OpenAIRE

    Gawrysiak, Michael J.; John P. Carvalho; Rogers, Baxter P.; Nicholas, Christopher R. N.; Dougherty, John H.; Hopko, Derek R.

    2012-01-01

    Functional neuroimaging is an innovative but at this stage underutilized method to assess the efficacy of psychotherapy for depression. Functional magnetic resonance imaging (fMRI) was used in this case study to examine changes in brain activity in a depressed breast cancer patient receiving an 8-session Behavioral Activation Treatment for Depression (BATD), based on the work of Hopko and Lejuez (2007). A music listening paradigm was used during fMRI brain scans to assess reward responsivenes...

  1. Skeletal Muscle Changes After Elective Colorectal Cancer Resection:A Longitudinal Study

    OpenAIRE

    Malietzis, George; Currie, Andrew C.; Johns, Neil; Fearon, Kenneth C.; Darzi, Ara; Kennedy, Robin H.; Athanasiou, Thanos; Jenkins, John T.

    2016-01-01

    Muscle depletion is a poor prognostic indicator in colorectal cancer (CRC) patients, but there were no data assessing comparative temporal body composition changes following elective CRC surgery. We examined patient skeletal muscle index trajectories over time after surgery and determined factors that may contribute to those alterations.Patients diagnosed with CRC undergoing elective surgical resection between 2006 and 2013 were included in this study. Image analysis of serial computed tomogr...

  2. Pathological changes on human breast cancer specimens ablated in vitro with high-intensity focused ultrasound.

    Science.gov (United States)

    Niu, Lingchuan; Wang, Zhibiao; Zou, Wenbing; Zhang, Lian; Xiang, Like; Zhu, Hui; Chen, Wenzhi; Bai, Jin; Wu, Junru

    2010-09-01

    The purpose of this study was to evaluate the pathologic changes of human breast cancer specimens ablated with high-intensity focused ultrasound (HIFU) in vitro. Twenty specimens of pathologically confirmed breast cancer tissue were ablated with ultrasound-guided HIFU. The evaluation methods include histopathologic observation using hematoxylin-eosin staining, electron microscopic imaging, enzyme histochemical and immunohistochemical examination on tumor antigens. Vacuole-like structures in cytoplasm were observed by histopathologic observation but there were no significant changes in cell morphology and nucleus karyotype. Typical phenomena related to coagulation necrosis were observed in electron microscopic studies; the contour of cell structure was still preserved but the structures of cell (all kinds of organelles and nucleus) were damaged or disappeared. Acid phosphatase and succinate dehydrogenase staining showed that tumor cells were inactivated. In immunohistochemical evaluations, estrogen receptor, progesterone receptor, cerbB-2 and P53 expression changed from 85%, 82%, 75% and 80% in nonablation tissue to no expression in ablated tumor tissue, respectively. We, therefore, conclude that breast cancer cells appear normal contour immediately after ablation with HIFU under light microscopic but they were evaluated to be dead by electron microscopic imaging, enzyme histochemical and immunohistochemical examinations. PMID:20800171

  3. Weight change later in life and colon and rectal cancer risk in participants in the EPIC-PANACEA study

    DEFF Research Database (Denmark)

    Steins Bisschop, Charlotte N; van Gils, Carla H; Emaus, Marleen J;

    2014-01-01

    BACKGROUND: A moderate association exists between body mass index (BMI) and colorectal cancer. Less is known about the effect of weight change. OBJECTIVE: We investigated the relation between BMI and weight change and subsequent colon and rectal cancer risk. DESIGN: This was studied among 328......,781 participants in the prospective European Prospective Investigation into Cancer-Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating study (mean age: 50 y). Body weight was assessed at recruitment and on average 5 y later. Self-reported weight change (kg/y) was categorized in sex...

  4. Engaging patients in public policy advocacy.

    Science.gov (United States)

    Collins, Charlotte W; Moore, Nuala S

    2014-02-01

    Health professionals can and should be game-changing influencers of U.S. health policies. The American Thoracic Society (ATS) is enabling its members to advocate on important issues through such initiatives as the Breathing Better Alliance network and the annual ATS Hill Day. Patients are also organizing to make their voices heard by participating in the member organizations of the ATS Public Advisory Roundtable and by accompanying ATS members and staff on visits to legislators and government regulators. If we join together, we can amplify our messages and promote better health policies. Doing so will require us to embrace a partnership steeped in trust and hope. PMID:24575996

  5. The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer.

    Directory of Open Access Journals (Sweden)

    Joanna Zhuang

    2012-02-01

    Full Text Available Aberrant DNA methylation is an important cancer hallmark, yet the dynamics of DNA methylation changes in human carcinogenesis remain largely unexplored. Moreover, the role of DNA methylation for prediction of clinical outcome is still uncertain and confined to specific cancers. Here we perform the most comprehensive study of DNA methylation changes throughout human carcinogenesis, analysing 27,578 CpGs in each of 1,475 samples, ranging from normal cells in advance of non-invasive neoplastic transformation to non-invasive and invasive cancers and metastatic tissue. We demonstrate that hypermethylation at stem cell PolyComb Group Target genes (PCGTs occurs in cytologically normal cells three years in advance of the first morphological neoplastic changes, while hypomethylation occurs preferentially at CpGs which are heavily Methylated in Embryonic Stem Cells (MESCs and increases significantly with cancer invasion in both the epithelial and stromal tumour compartments. In contrast to PCGT hypermethylation, MESC hypomethylation progresses significantly from primary to metastatic cancer and defines a poor prognostic signature in four different gynaecological cancers. Finally, we associate expression of TET enzymes, which are involved in active DNA demethylation, to MESC hypomethylation in cancer. These findings have major implications for cancer and embryonic stem cell biology and establish the importance of systemic DNA hypomethylation for predicting prognosis in a wide range of different cancers.

  6. Prospective cohort study of general and central obesity, weight change trajectory and risk of major cancers among Chinese women.

    Science.gov (United States)

    Liu, Ying; Warren Andersen, Shaneda; Wen, Wanqing; Gao, Yu-Tang; Lan, Qing; Rothman, Nathaniel; Ji, Bu-Tian; Yang, Gong; Xiang, Yong-Bing; Shu, Xiao-Ou; Zheng, Wei

    2016-10-01

    General obesity, typically measured using body mass index (BMI), has been associated with an increased risk of several cancers. However, few prospective studies have been conducted in Asian populations. Although central obesity, often measured using waist-hip ratio (WHR), is more predictive for type 2 diabetes and cardiovascular diseases (CVD) risk than BMI, knowledge of its association with cancer incidence is limited. In a cohort of 68,253 eligible Chinese women, we prospectively investigated the association of BMI, WHR and weight change during adulthood with risk of overall cancer and major site-specific cancers using multivariate Cox proportional hazard models. Compared to the BMI group of 18.5-22.9 kg/m(2) , obese (BMI ≥ 30 kg/m(2) ) women were at an increased risk of developing overall cancer (hazard ratio = 1.36, 95% confidence interval = 1.21-1.52), postmenopausal breast cancer (HR: 2.43, 95% CI: 1.73-3.40), endometrial cancer (HR: 5.34, 95% CI: 3.48-8.18), liver cancer (HR: 1.93, 95% CI: 1.14-3.27) and epithelial ovarian cancer (HR: 2.44, 95% CI: 1.37-4.35). Weight gain during adulthood (per 5 kg gain) was associated with increased risk of all cancers combined (HR: 1.05, 95% CI: 1.03-1.08), postmenopausal breast cancer (HR: 1.17, 95% CI: 1.10-1.24) and endometrial cancer (HR: 1.37, 95% CI: 1.27-1.48). On the other hand, WHR was not associated with cancer risk after adjustment for baseline BMI. These findings suggest that obesity may be associated with cancer risk through different mechanisms from those for type 2 diabetes and CVD and support measures of maintaining health body weight to reduce cancer risk in Chinese women. PMID:27177094

  7. Inflammatory changes in biopsy specimens from patients with suspected prostate cancer

    Directory of Open Access Journals (Sweden)

    Zbigniew Wolski

    2013-06-01

    Full Text Available Introduction. Prostate cancer (PCa is one of the most commonly diagnosed cancers in elderly men, and accounts for 30% of all newly diagnosed cases of cancer. The development of the ‘clinically insignificant’ prostate cancer into its invasive form is still unclear, and it is believed that chronic inflammation may play its role, as proposed by De Marzo in 1999. However, there is no clear opinion on the subject of existence of dependencies between changes of the inflammatory type and PCa.Material and methods. The study involved 1,010 men, suspected of prostate cancer development by positive digital rectal examination (DRE and/or elevated PSA value. The 10 cores, TRUS guided biopsy was performed. In those with ASAP, HG–PIN or inflammation the second biopsy was proposed.Results. In the first biopsy PCa was diagnosed in 336 patients (33.27%. ASAP was found in 58 (5.74%, HG–PIN in 82 (8.11%, and the coexistence of both was found in 19 (1.88%. Chronic prostatitis was diagnosed in 101 (10% men. Of those who underwent second biopsy, PCa was diagnosed in six of 19 patients (31.57% who were diagnosed with HG–PIN in the first biopsy, in four of 40 (10% with BPH in the first biopsy, in four of 18 (22.22% with ASAP or LG–PIN together with ASAP, and in two out of five (40% with the coexistence of ASAP and HG–PIN. Malignancy was not confirmed in any of the patients in whom the diagnosis of BPH, HG–PIN, or ASAP was accompanied by chronic prostatitis.Conclusions. Chronic prostatitis does not significantly increase the value of PSA in patients with benign changes (BPH. The presence of prostatitis in the first biopsy did not predict cancer in subsequent biopsy, because the second biopsy did not reveal prostate cancer in any of the patients in whom prostatitis was diagnosed in the first biopsy.

  8. Evaluation of resident attitudes and self-reported competencies in health advocacy

    Directory of Open Access Journals (Sweden)

    Fok Mark C

    2010-11-01

    Full Text Available Abstract Background The CanMEDS Health Advocate role, one of seven roles mandated by the Royal College of Physicians and Surgeons Canada, pertains to a physician's responsibility to use their expertise and influence to advance the wellbeing of patients, communities, and populations. We conducted our study to examine resident attitudes and self-reported competencies related to health advocacy, due to limited information in the literature on this topic. Methods We conducted a pilot experience with seven internal medicine residents participating in a community health promotion event. The residents provided narrative feedback after the event and the information was used to generate items for a health advocacy survey. Face validity was established by having the same residents review the survey. Content validity was established by inviting an expert physician panel to review the survey. The refined survey was then distributed to a cohort of core Internal Medicine residents electronically after attendance at an academic retreat teaching residents about advocacy through didactic sessions. Results The survey was completed by 76 residents with a response rate of 68%. The majority agreed to accept an advocacy role for societal health needs beyond caring for individual patients. Most confirmed their ability to identify health determinants and reaffirmed the inherent requirements for health advocacy. While involvement in health advocacy was common during high school and undergraduate studies, 76% of residents reported no current engagement in advocacy activity, and 36% were undecided if they would engage in advocacy during their remaining time as residents, fellows or staff. The common barriers reported were insufficient time, rest and stress. Conclusions Medical residents endorsed the role of health advocate and reported proficiency in determining the medical and bio-psychosocial determinants of individuals and communities. Few residents, however, were

  9. Health care access and advocacy for immigrant and other underserved elders.

    Science.gov (United States)

    Yee, D L

    1992-01-01

    Little is known about health care access and advocacy for elders of color, and even less is known about immigrant elders, whose growing number is the major reason that almost one of every three older persons in the U.S. by the year 2050 will be an elder of color. This paper explores a number of access barriers faced by underserved elders, including inequitable long-term care services and counterproductive "colorblind" approaches to caregiving. It also addresses barriers, such as problematic immigration policies, that present particular challenges to elderly immigrants. While available materials provide baseline information and help providers learn about underserved elders, real change in how target populations gain access to health and social services comes when providers make explicit efforts to improve the accessibility and quality of services. PMID:1606278

  10. Sleep disturbances and changes in urinary 6-sulphatoxymelatonin levels in patients with breast cancer undergoing lumpectomy

    DEFF Research Database (Denmark)

    Voigt Hansen, Melissa; Madsen, M T; Wildschiødtz, Gordon;

    2013-01-01

    Sleep disturbances and changes in self-reported discomfort and melatonin secretion are common in the post-operative period. We aimed to study the distribution of sleep stages in the perioperative period and evaluate changes in secretion of the melatonin metabolite aMT6s and subjective parameters ...... of sleepiness, pain, general well-being and fatigue in patients undergoing surgery for breast cancer.......Sleep disturbances and changes in self-reported discomfort and melatonin secretion are common in the post-operative period. We aimed to study the distribution of sleep stages in the perioperative period and evaluate changes in secretion of the melatonin metabolite aMT6s and subjective parameters...

  11. 76 FR 78342 - Open Meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee

    Science.gov (United States)

    2011-12-16

    ...An open meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas, and suggestions on improving customer service at the Internal Revenue...

  12. 77 FR 37101 - Open Meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee

    Science.gov (United States)

    2012-06-20

    ...An open meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas, and suggestions on improving customer service at the Internal Revenue...

  13. 77 FR 30591 - Open Meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee

    Science.gov (United States)

    2012-05-23

    ...An open meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas, and suggestions on improving customer service at the Internal Revenue...

  14. 77 FR 47166 - Open Meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee

    Science.gov (United States)

    2012-08-07

    ...An open meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee will be conducted. The Taxpayer Advocacy Panel is soliciting public comments, ideas, and suggestions on improving customer service at the Internal Revenue...

  15. Neglected zoonotic diseases-the long and winding road to advocacy.

    Directory of Open Access Journals (Sweden)

    Hayley E Mableson

    2014-06-01

    Full Text Available BACKGROUND: Years of advocacy for the neglected tropical diseases (NTDs have focused the world's attention on these diseases of the poor, resulting most recently in the 2012 "London Declaration" and the recent World Health Assembly Resolution WHA66.12 on NTDs in May 2013. Control of the endemic neglected zoonotic diseases (NZDs would benefit from a similar campaign, which needs the support of a global community. METHODOLOGY/PRINCIPAL FINDINGS: The resolutions from all 66 World Health Assembly (WHA meetings held between 1948 and 2013 were examined to determine how many contain a specific focus on any of the following eight NZDs as defined by the World Health Organisation (WHO: anthrax, bovine tuberculosis (TB, brucellosis, Taenia solium cysticercosis, cystic echinococcosis (hydatidosis, leishmaniasis, rabies, and zoonotic human African trypanosomiasis (HAT or sleeping sickness. Twenty-one resolutions adopted in the 16 assemblies between 1948 and 2013 targeted one or more of these eight NZDs, representing 4% of the total resolutions on infectious diseases passed to date. The 2013 adoption of Resolution WHA66.12 targeting all 17 NTDs marks a change in approach by the WHA. Whereas previous resolutions have targeted the NTDs as separate entities, the new approach of the combined resolution will help increase the overall momentum to target these ancient diseases as coendemic clusters in endemic countries. However, three major NZDs remain outside this recent resolution: anthrax, brucellosis, and bovine TB. CONCLUSIONS AND SIGNIFICANCE: The recent adoption of a specific resolution at the WHA in 2013 that emphasises a One Health approach for the successful control of 17 NTDs is a major development in advocacy. However, recognition of the importance of three major NZDs to public health in endemic countries-anthrax, brucellosis, and bovine tuberculosis-is still lacking despite being prioritised by the WHA as early as the 1950s. Global advocacy for control

  16. Radiation-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients

    Directory of Open Access Journals (Sweden)

    Karol Jelonek

    2014-04-01

    Full Text Available Cancer radiotherapy (RT induces response of the whole patient’s body that could be detected at the blood level. We aimed to identify changes induced in serum lipidome during RT and characterize their association with doses and volumes of irradiated tissue. Sixty-six patients treated with conformal RT because of head and neck cancer were enrolled in the study. Blood samples were collected before, during and about one month after the end of RT. Lipid extracts were analyzed using MALDI-oa-ToF mass spectrometry in positive ionization mode. The major changes were observed when pre-treatment and within-treatment samples were compared. Levels of several identified phosphatidylcholines, including (PC34, (PC36 and (PC38 variants, and lysophosphatidylcholines, including (LPC16 and (LPC18 variants, were first significantly decreased and then increased in post-treatment samples. Intensities of changes were correlated with doses of radiation received by patients. Of note, such correlations were more frequent when low-to-medium doses of radiation delivered during conformal RT to large volumes of normal tissues were analyzed. Additionally, some radiation-induced changes in serum lipidome were associated with toxicity of the treatment. Obtained results indicated the involvement of choline-related signaling and potential biological importance of exposure to clinically low/medium doses of radiation in patient’s body response to radiation.

  17. Changes in knowledge of cervical cancer following introduction of human papillomavirus vaccine among women at high risk for cervical cancer

    Directory of Open Access Journals (Sweden)

    L. Stewart Massad

    2015-04-01

    Conclusion: Substantial gaps in understanding of HPV and cervical cancer prevention exist despite years of health education. While more effective educational interventions may help, optimal cancer prevention may require opt-out vaccination programs that do not require nuanced understanding.

  18. 76 FR 78931 - Food and Drug Administration Rare Disease Patient Advocacy Day; Notice of Meeting

    Science.gov (United States)

    2011-12-20

    ... HUMAN SERVICES Food and Drug Administration Food and Drug Administration Rare Disease Patient Advocacy... Disease Patient Advocacy Day. This meeting is intended to enhance the awareness of the rare disease..., and devices) intended for the diagnosis, prevention, and/or treatment of rare diseases or...

  19. POLICY ADVOCACY IN SCIENCE: PREVALENCE, PERSPECTIVES, AND IMPLICATIONS FOR CONSERVATION BIOLOGISTS

    Science.gov (United States)

    Much debate and discussion has focused on the relationship between science and advocacy, and the role of scientists in influencing public policy. Some argue that advocacy is widespread within scientific literature, however, data to evaluate that contention are lacking. We examine...

  20. Weber's Critique of Advocacy in the Classroom: Critical Thinking and Civic Education.

    Science.gov (United States)

    Weaver, Mark

    1998-01-01

    Discusses the four aspects of Max Weber's argument against including advocacy in the political science classroom. Believes that Weber's critique is a useful starting point for considering the issue in relation to contemporary education. Describes two models, critical thinking and civic education, that present advocacy in the political science…

  1. What History Is Teaching Us: 100 Years of Advocacy in "Music Educators Journal"

    Science.gov (United States)

    Hedgecoth, David M.; Fischer, Sarah H.

    2014-01-01

    As "Music Educators Journal" celebrates its centennial, it is appropriate to look back over the past century to see how advocacy in music education has evolved. Of the more than 200 submitted articles on advocacy, four main themes emerged: music education in community, the relevancy of music education, the value of music education, and…

  2. Whistle-Blowing as a Form of Advocacy: Guidelines for the Practitioner and Organization

    Science.gov (United States)

    Greene, Annette D.; Latting, Jean Kantambu

    2004-01-01

    Advocacy has been an inherent component of social work since the mid-1800s. The NASW Code of Ethics explicitly promotes advocacy as an ethical stance against inhumane conditions. Whistle-blowing, on the other hand, occurs mostly in the business and public administration disciplines and is relatively unknown in the social work profession. Using…

  3. Advocacy and Empowerment in Parent Consultation: Implications for Theory and Practice

    Science.gov (United States)

    Holcomb-McCoy, Cheryl; Bryan, Julia

    2010-01-01

    In this article, the authors expand the view of parental consultation to include advocacy and empowerment as important contextual considerations. A brief review of existing approaches to parent consultation is provided. Selected advances in multicultural parent consultation are also presented. An advocacy- and empowerment-focused perspective is…

  4. Fighting for Their Rights: Advocacy Experiences of Parents of Children Identified with Intellectual Giftedness

    Science.gov (United States)

    Duquette, Cheryll; Orders, Shari; Fullarton, Stephanie; Robertson-Grewal, Kristen

    2011-01-01

    This research examined the advocacy experiences of 16 parents of adolescents and young adults who had been assessed as intellectually gifted. The purpose was to determine the applicability of the four dimensions of advocacy to their experiences (awareness, information seeking, presenting the case, and monitoring). Participants responded to a…

  5. Insider, Outsider, Ally, or Adversary: Parents of Youth with Learning Disabilities Engage in Educational Advocacy

    Science.gov (United States)

    Duquette, Cheryll; Fullarton, Stephanie; Orders, Shari; Robertson-Grewal, Kristen

    2011-01-01

    The purpose of this qualitative study was to examine the educational advocacy experiences of parents of adolescents and young adults identified as having a learning disability (LD) through the lens of four dimensions of advocacy. Seventeen mothers of youth with LD responded to items in a questionnaire and 13 also engaged in in-depth interviews. It…

  6. Understanding Parent Advocacy during the Transition to School of Children with Developmental Disabilities: Three Canadian Cases

    Science.gov (United States)

    Hutchinson, Nancy L.; Pyle, Angela; Villeneuve, Michelle; Dods, Jennifer; Dalton, C. J.; Minnes, Patricia

    2014-01-01

    Research has shown the benefits of parent involvement for student participation in education. Parent advocacy is a critical form of involvement by parents for children who are young, have disabilities, and are making transitions. Studies have classified forms of parent advocacy but have not illuminated the components necessary for effective parent…

  7. Fostering Skills in Self-Advocacy: A Key to Access in School and Beyond

    Science.gov (United States)

    Luckner, John L.; Becker, Sharon J.

    2013-01-01

    Self-advocacy occurs when deaf or hard of hearing individuals explain to hearing teachers, classmates, bosses, and officemates the nature of their hearing loss, their language skills, and the accommodations they require in order to effectively do their work, participate in conversations, and get involved in other activities. Self-advocacy may be…

  8. Development of the Policy Advocacy Behavior Scale: Initial Reliability and Validity

    Science.gov (United States)

    Donaldson, Linda Plitt; Shields, Joseph

    2009-01-01

    Contemporary trends in social service delivery systems require human service agencies to engage in greater levels of advocacy to reform structures and protect programs that serve vulnerable populations. Objective: The purpose of this study was to develop an instrument to measure the policy advocacy behavior of nonprofit human service agencies.…

  9. Management, Leadership, and User Control in Self-Advocacy: An English Case Study

    Science.gov (United States)

    Tilley, Elizabeth

    2013-01-01

    This paper presents findings from a qualitative research project on an English self-advocacy organization. In light of recent political and economic developments that have threatened the sustainability of a number of self-advocacy groups for people with intellectual disability, I seek to explore how one particular organization managed to survive…

  10. Questioning the Role of "21st-Century Skills" in Arts Education Advocacy Discourse

    Science.gov (United States)

    Logsdon, Leann F.

    2013-01-01

    The revised Core Arts Standards offer music educators the chance to examine the contradictions that currently permeate the arts advocacy discourse. This article examines the emphasis on 21st-century workplace skills in claims made by arts advocacy proponents. An alternative approach focuses instead on lifelong learning in the arts and the array of…

  11. Impact of a Legal Advocacy Program on Services in a State Residential Facility.

    Science.gov (United States)

    Holburn, C. Steve

    1982-01-01

    The impact of a unique, federally funded legal advocacy system on service delivery within a New Mexico state residential care facility for the mentally retarded is examined. Judicial attempts to improve institutional service provision are discussed. Some implications for further use of similar advocacy programs are presented. (Author/CL)

  12. Learning about Advocacy, A Case-Study of Challenges, Everyday Practices

    NARCIS (Netherlands)

    Ringsing, B.; Leeuwis, C.

    2008-01-01

    Advocacy has become an important area of development support. Simultaneously, the interest in learning-oriented monitoring of advocacy programmes has increased. Starting from the premise that learning has sociopolitical dimensions, this article explores how the challenges and contradictions of such

  13. Do changes in lymph node status distribution explain trends in survival of breast cancer patients in Denmark?

    DEFF Research Database (Denmark)

    Rostgaard, Klaus; Vaeth, Michael; Rootzén, Helle;

    2006-01-01

    We studied the impact on survival of changes in breast cancer patients' distribution by lymph node status at the time of diagnosis. Our study included breast cancer patients diagnosed from 1978 to 1994 in Denmark, where the treatment schemes for breast cancer patients were fairly stable, and wher...... distribution explained half of the improvement in 5-year relative survival, and seem to be the single most important cause behind the improved survival of breast cancer patients in Denmark.......We studied the impact on survival of changes in breast cancer patients' distribution by lymph node status at the time of diagnosis. Our study included breast cancer patients diagnosed from 1978 to 1994 in Denmark, where the treatment schemes for breast cancer patients were fairly stable, and where...... mammography screening was limited. We measured lymph node status by the proportion of positive lymph nodes of all excised lymph nodes, as assessed by a pathologist. This measure was available for two-thirds of the breast cancer patients. The outcome was 5-year relative survival. Changes in lymph node status...

  14. The Effects of Advocacy Advertising and Situational Crisis on Perceptions of Social Responsibility, Potential Supportive Behavior and Attitudes Toward Advertisements.

    Science.gov (United States)

    Cozby, Jeanie G.; And Others

    Data were collected from 176 college students in a study of the effects of corporate advocacy advertising in crisis situations. The subjects read one of two sets of oil company advertisements, one set using a low advocacy and the other set using a high advocacy approach to explain company activities in relation to current events and social issues.…

  15. 77 FR 40411 - Open Meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee

    Science.gov (United States)

    2012-07-09

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project... meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee will be conducted....C. App. (1988) that a meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods...

  16. 77 FR 55525 - Open Meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee

    Science.gov (United States)

    2012-09-10

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project... meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee will be conducted....C. App. (1988) that a meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods...

  17. 77 FR 8328 - Open Meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee

    Science.gov (United States)

    2012-02-14

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project... meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee will ] be conducted....C. App. (1988) that a meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods...

  18. 77 FR 61053 - Open Meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee

    Science.gov (United States)

    2012-10-05

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project... meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee will be conducted....C. App. (1988) that a meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods...

  19. 77 FR 21157 - Open Meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee

    Science.gov (United States)

    2012-04-09

    ... Internal Revenue Service Open Meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project... meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee will be conducted.... (1988) that a meeting of the Taxpayer Advocacy Panel Face-to-Face Service Methods Project Committee...

  20. The Commissioning and Provision of Advocacy for Problem Drug Users in English DATS: A Cross-Sectional Survey

    Science.gov (United States)

    Cargill, Tamsin; Weaver, Tim D.; Patterson, Sue

    2012-01-01

    Aims: This study investigated the commissioning and delivery of advocacy for problem drug users. We aimed to quantify provision, describe the commissioning of advocacy services in Drug Action Teams (DATs) and to identify factors influencing advocacy provision. Methods: A cross-sectional survey of a randomly selected sample of 50 English DATs. The…

  1. Longitudinal study of sexual function and vaginal changes after radiotherapy for cervical cancer

    DEFF Research Database (Denmark)

    Jensen, Pernille T; Groenvold, Mogens; Klee, Marianne C;

    2003-01-01

    PURPOSE: To investigate the longitudinal course of self-reported sexual function and vaginal changes in patients disease free after radiotherapy (RT) for locally advanced, recurrent, or persistent cervical cancer. MATERIALS AND METHODS: A total of 118 patients referred for RT were included....... The patients were assessed, using a validated self-assessment questionnaire, at the termination of RT and 1, 3, 6, 12, 18, and 24 months later. The results were compared with an age-matched control group from the general population. RESULTS: Persistent sexual dysfunction and adverse vaginal changes were...... reported throughout the 2 years after RT, with small changes over time: approximately 85% had low or no sexual interest, 35% had moderate to severe lack of lubrication, 55% had mild to severe dyspareunia, and 30% were dissatisfied with their sexual life. A reduced vaginal dimension was reported by 50...

  2. Changes of splenic macrophage during the process of liver cancer induced by diethylnitrosamine in rats

    Institute of Scientific and Technical Information of China (English)

    ZHANG Shu; LI Zong-fang; PAN Dun; HUANG Chen; ZHOU Rui; LIU Zhong-wei

    2009-01-01

    Background It is generally accepted that spleen plays a complex role in the tumor immunity, which would change in the different periods of cancer. In this study, we investigated the changes in the function of splenic macrophage (Mφ) in different stages of liver cancer induced by diethylnitrosamine (DEN) in rats. The aim was to support the characteristics of "two-way" and "phase" of spleen in tumor immunity.Methods The model of pulmonary metastasis of liver cancer was established in forty male SD rats by DEN. In the 8th, 13th and 16th week, 10 rats were randomly chosen and sacrificed, and divided into cirrhosis, liver cancer and pulmonary metastasis groups depending on the pathological result, respectively. The other 10 rats were taken as control group. The Mφ was isolated by anchoring cultivation. The changes in ultrastructure, phagocytosis, cytokine secretion, antigen processing and presenting, and viability of splenic Mφ were detected by transmission electron microscopy, Vybrant~(TM) Phagocytosis Assay, DQ~(TM) Ovalbumin, and rat TNF-α ELISpot kits.Results Under the electron microscope, the Mφ in the control group had some pseudopodium-like prominences, and mitochondria, ribosome, rough endoplasmic reticulum, lysosome can be found in the cytoplasm, and phagocytized RBC. In the liver cirrhosis and liver cancer group, Mφ had more prominences, meanwhile much more mitochondria, ribosome, rough endoplasmic reticulum, lysosome can be found in the cytoplasm, especially in the liver cancer group. In the pulmonary metastasis group, the Mφ was swelling, with few organelle. As compared to the control group, the function of splenic Mφ increased in cirrhosis and cancer groups, but decreased in metastasis group (phagocytosis rate: (84.7±1.9)%, (89.5±3.1)%, and (36.0±2.6)% vs (75.6±1.7)%, P<0.05, P<0.01; viability: (1.53±0.15)%, (1.56±0.14)%, and (1.12±0.29)% vs (1.48±0.17)%, P <0.05, P <0.01; TNF-a secretion: (741.0±52.9)%, (1126.2±174.5)%, and (313.8±50

  3. Developing advocacy for geothermal energy in the United States

    International Nuclear Information System (INIS)

    There is little public advocacy for geothermal energy in the United States outside of the geothermal community itself. Yet, broad-based advocacy is needed to provide impetus for a nourishing economic, regulatory and R and D environment. If such an environment could be created, the prosperity of the geothermal industry would improve and positive environmental effects compared to most other energy sources would be realized. We need an organized sustained effort to provide information and education to all segments of our society, including market-makers and end users, administrators, legislators, regulators, educators, special-interest groups and the public. This effort could be provided by an organization of three main components, a network to gather and disseminate pertinent information on marketing, educational and lobbying opportunities to action committees, a repository of current information on geothermal energy, and action committees each responsible for certain parts of the total marketing, education and lobbying task. In this paper, the author suggests a mechanism for forming such an organization and making it work. The author proposes an informal organization staffed largely by volunteered labor in which no one person would have to devote more than a few percent of his or her work time

  4. The study on changes of rectum area in proton prostate cancer therapy

    Science.gov (United States)

    Kim, S. Y.; Lee, H. K.; Shin, H. W.; Kim, S. C.; Cho, J. H.

    2015-10-01

    The purpose of this study is to determine the changes in the rectum area during treatment and to identify the rectum area within the given field of view in order to reproduce the same pose as that presented during therapy planning to properly deliver the planned dose to the prostate. We obtained digitally reconstructed radiographs after planning treatment for 30 patients out of all patients who had been subjected to proton prostate cancer therapy from August 2012 to November 2014 at this hospital. We then obtained an image using a digital imaging positioning system (DIPS) on the first day of treatment. When planning the digitally reconstructed radiograph treatment, we determined the change in size of the rectum between the actual treatment and treatment planning by measuring the cross section of the rectum and the cross section on the image from the DIPS. The results indicated that the rectum area in the digitally reconstructed radiograph taken during treatment planning and the rectum area obtained from the DIPS image during treatment were different. As a consequence, when region targeted for proton treatment of prostate cancer does not maintain a constant volume, the position of the prostate does not receive an adequate dose due to such changes. Therefore, the results of this study will be useful to determine the corresponding volume during a prostate treatment plan.

  5. Fractionated changes in prostate cancer radiotherapy using cone-beam computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Tzung-Chi, E-mail: tzungchi.huang@mail.cmu.edu.tw [Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung City, Taiwan (China); Department of Biomedical Informatics, Asia University, Taichung City, Taiwan (China); Chou, Kuei-Ting [Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung City, Taiwan (China); Yang, Shih-Neng [Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung City, Taiwan (China); Department of Biomedical Informatics, Asia University, Taichung City, Taiwan (China); Chang, Chih-Kai [Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung City, Taiwan (China); Liang, Ji-An [Department of Radiation Oncology, China Medical University Hospital, Taichung City, Taiwan (China); Zhang, Geoffrey [Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL (United States)

    2015-10-01

    The high mobility of the bladder and the rectum causes uncertainty in radiation doses prescribed to patients with prostate cancer who undergo radiotherapy (RT) multifraction treatments. The purpose of this study was to estimate the dose received by the bladder, rectum, and prostate from multifraction treatments using daily cone-beam computed tomography (CBCT). Overall, 28 patients with prostate cancer who planned to receive radiation treatments were enrolled in the study. The acquired CBCT before the treatment delivery was registered with the planning CT to map the dose distribution used in the treatment plan for estimating the received dose during clinical treatment. For all 28 patients with 112 data sets, the mean percentage differences (± standard deviation) in the volume and radiation dose were 44% (± 41) and 18% (± 17) for the bladder, 20% (± 21) and 2% (± 2) for the prostate, and 36% (± 29) and 22% (± 15) for the rectum, respectively. Substantial differences between the volumes and radiation dose and those specified in treatment plans were observed. Besides the use of image-guided RT to improve patient setup accuracy, further consideration of large changes in bladder and rectum volumes is strongly suggested when using external beam radiation for prostate cancer.

  6. Changes in T-lymphocytes in lung cancer patients after hyperthermic intraperitoneal chemotherapy or radiotherapy.

    Science.gov (United States)

    Yan, L; Wu, M; Ba, N; Shi, G; Wang, L; Zhang, H

    2016-01-01

    We investigated dynamic changes in T-lymphocyte subsets after hyperthermic intraperitoneal chemotherapy (HIPEC) or radiotherapy using flow cytometry. A total of 1423 lung cancer patients admitted to our hospital between October 2012 and July 2015 were enrolled, and age-matched healthy individuals served as controls. Peripheral blood mononuclear cells (PBMCs) were purified using standard Ficoll density gradient centrifugation, based on which CD3+, CD4+, and CD8+ T-cells were isolated. A surface marker was identified by flow cytometry. Immunohistochemical analysis determined the distribution of the cells in the tumor mass or adjacent tissues. A total of 957 patients (male: 555; female: 402; median age: 49.3 years) with lung cancer who had received only HIPEC or radiotherapy were enrolled. The patients were followed-up until death. No statistical difference was noticed between the patients who had received chemotherapy compared with the baseline levels. A remarkable elevation was noticed in the CD3+ T-cells in the patients three months after radiotherapy (78.71 ± 9.36 vs 68.15 ± 9.65, P tumor infiltration and metastasis. Remarkable elevation was noticed in the CD3+ T-cells in the patients three months after radiotherapy. The expression of CD3+ and CD4+ was negatively correlated to tumor infiltration and metastasis in non-small-cell lung cancer patients. PMID:27323163

  7. Changes in response properties of nociceptive dorsal horn neurons in a murine model of cancer pain

    Institute of Scientific and Technical Information of China (English)

    Donald A. Simone; Sergey G. Khasabov; Darryl T. Hamamoto

    2008-01-01

    Pain associated with cancer that metastasizes to bone is often severe and debilitating. A better understanding of the neural mechanisms that mediate cancer pain is needed for the development of more effective treatments. In this study, we used an established model of cancer pain to characterize changes in response properties of dorsal horn neurons. Fibrosarcoma cells were implanted into and around the calcaneus bone in mice and extracellular electrophysiological recordings were made from wide dynamic range (WDR) and high threshold (HT) dorsal horn neurons. Responses of WDR and HT neurons evoked by mechanical, heat, and cold stimuli applied to the plantar surface of the hind paw were compared between tumor bearing mice and control mice. Mice exhibited hyperalgesia to mechanical and heat stimuli applied to their tumor-bearing hind paw. WDR neurons in tumor-beating mice exhibited an increase in spontaneous activity, and enhanced responses to mechanical, heat, and cold stimuli as compared to controls. Our findings show that sensitization of WDR neurons, but not HT neurons, contributes to tumor-evoked hyperalgesia.

  8. Society for immunotherapy of cancer (SITC) statement on the proposed changes to the common rule.

    Science.gov (United States)

    Kaufman, Howard L; Butterfield, Lisa H; Coulie, Pierre G; Demaria, Sandra; Ferris, Robert L; Galon, Jérôme; Khleif, Samir N; Mellman, Ira; Ohashi, Pamela S; Overwijk, Willem W; Topalian, Suzanne L; Marincola, Francesco M

    2016-01-01

    The Common Rule is a set of ethical principles that provide guidance on the management of human subjects taking part in biomedical and behavioral research in the United States. The elements of the Common Rule were initially developed in 1981 following a revision of the Declaration of Helsinki in 1975. Most academic facilities follow the Common Rule in the regulation of clinical trials research. Recently, the government has suggested a revision of the Common Rule to include more contemporary and streamlined oversight of clinical research. In this commentary, the leadership of the Society for Immunotherapy of Cancer (SITC) provides their opinion on this plan. While the Society recognizes the considerable contribution of clinical research in supporting progress in tumor immunotherapy and supports the need for revisions to the Common Rule, there is also some concern over certain elements which may restrict access to biospecimens and clinical data at a time when high throughput technologies, computational biology and assay standardization is allowing major advances in understanding cancer biology and providing potential predictive biomarkers of immunotherapy response. The Society values its professional commitment to patients for improving clinical outcomes with tumor immunotherapy and supports continued discussion with all stakeholders before implementing changes to the Common Rule in order to ensure maximal patient protections while promoting continued clinical research at this historic time in cancer research. PMID:27330810

  9. Fractionated changes in prostate cancer radiotherapy using cone-beam computed tomography

    International Nuclear Information System (INIS)

    The high mobility of the bladder and the rectum causes uncertainty in radiation doses prescribed to patients with prostate cancer who undergo radiotherapy (RT) multifraction treatments. The purpose of this study was to estimate the dose received by the bladder, rectum, and prostate from multifraction treatments using daily cone-beam computed tomography (CBCT). Overall, 28 patients with prostate cancer who planned to receive radiation treatments were enrolled in the study. The acquired CBCT before the treatment delivery was registered with the planning CT to map the dose distribution used in the treatment plan for estimating the received dose during clinical treatment. For all 28 patients with 112 data sets, the mean percentage differences (± standard deviation) in the volume and radiation dose were 44% (± 41) and 18% (± 17) for the bladder, 20% (± 21) and 2% (± 2) for the prostate, and 36% (± 29) and 22% (± 15) for the rectum, respectively. Substantial differences between the volumes and radiation dose and those specified in treatment plans were observed. Besides the use of image-guided RT to improve patient setup accuracy, further consideration of large changes in bladder and rectum volumes is strongly suggested when using external beam radiation for prostate cancer

  10. Change of the cell cycle after flutamide treatment in prostate cancer cells and its molecular mechanism

    Institute of Scientific and Technical Information of China (English)

    Yong Wang; Wei-Jun Qin; He Wang; Guo-Xing Shao; Chen Shao; Chang-Hong Shi; Lei Zhang; Hong-Hong Yue; Peng-Fei Wang; Bo Yang; Yun-Tao Zhang; Fan Liu

    2005-01-01

    Aim: To explore the effect of androgen receptor (AR) on the expression of the cell cycle-related genes, such as CDKN1A and BTG1, in prostate cancer cell line LNCaP. Methods: After AR antagonist flutamide treatment and confirmation of its effect by phase contrast microscope and flow cytometry, the differential expression of the cell cycle-related genes was analyzed by a cDNA microarray. The flutamide treated cells were set as the experimental group and the LNCaP cells as the control. We labeled cDNA probes of the experimental group and control group with Cy5 and Cy3 dyes, respectively, through reverse transcription. Then we hybridized the cDNA probes with cDNA microarrays, which contained 8 126 unique human cDNA sequences and the chip was scanned to get the fluorescent values of Cy5 and Cy3 on each spot. After primary analysis, reverse transcription polymerase chain reaction (RTPCR) tests were carried out to confirm the results of the chips. Results:After AR antagonist flutamide treatment,three hundred and twenty-six genes (3.93 %) expressed differentially, 97 down-regulated and 219 up-regulated.Among them, eight up-regulated genes might be cell cycle-related, namely CDC10, NRAS, BTG1, Weel, CLK3,DKFZP564A122, CDKN1A and BTG2. The CDKN1A and BTG1 gene mRNA expression was confirmed to be higher in the experimental group by RT-PCR, whilep53 mRNA expression had no significant changes. Conclusion: Flutamide treatment might up-regulate CDKN1A and BTG1 expression in prostate cancer cells. The protein expressions of CDKN1A and BTG1 play an important role in inhibiting the proliferation of cancer cells. CDKN1A has a great impact on the cell cycle of prostate cancer cells and may play a role in the cancer cells in a p53-independent pathway. The prostate cancer cells might affect the cell cycle-related genes by activating AR and thus break the cell cycle control.

  11. DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage

    Directory of Open Access Journals (Sweden)

    DeGeest Koen

    2008-09-01

    Full Text Available Abstract Background Hypermethylation of promoter CpG islands with associated loss of gene expression, and hypomethylation of CpG-rich repetitive elements that may destabilize the genome are common events in most, if not all, epithelial cancers. Methods The methylation of 6,502 CpG-rich sequences spanning the genome was analyzed in 137 ovarian samples (ten normal, 23 low malignant potential, 18 stage I, 16 stage II, 54 stage III, and 16 stage IV ranging from normal tissue through to stage IV cancer using a sequence-validated human CpG island microarray. The microarray contained 5' promoter-associated CpG islands as well as CpG-rich satellite and Alu repetitive elements. Results Results showed a progressive de-evolution of normal CpG methylation patterns with disease progression; 659 CpG islands showed significant loss or gain of methylation. Satellite and Alu sequences were primarily associated with loss of methylation, while promoter CpG islands composed the majority of sequences with gains in methylation. Since the majority of ovarian tumors are late stage when diagnosed, we tested whether DNA methylation profiles could differentiate between normal and low malignant potential (LMP compared to stage III ovarian samples. We developed a class predictor consisting of three CpG-rich sequences that was 100% sensitive and 89% specific when used to predict an independent set of normal and LMP samples versus stage III samples. Bisulfite sequencing confirmed the NKX-2-3 promoter CpG island was hypermethylated with disease progression. In addition, 5-aza-2'-deoxycytidine treatment of the ES2 and OVCAR ovarian cancer cell lines re-expressed NKX-2-3. Finally, we merged our CpG methylation results with previously published ovarian expression microarray data and identified correlated expression changes. Conclusion Our results show that changes in CpG methylation are cumulative with ovarian cancer progression in a sequence-type dependent manner, and that Cp

  12. Exon-level transcriptome profiling in murine breast cancer reveals splicing changes specific to tumors with different metastatic abilities.

    Directory of Open Access Journals (Sweden)

    Amandine Bemmo

    Full Text Available BACKGROUND: Breast cancer is the second most frequent type of cancer affecting women. We are increasingly aware that changes in mRNA splicing are associated with various characteristics of cancer. The most deadly aspect of cancer is metastasis, the process by which cancer spreads from the primary tumor to distant organs. However, little is known specifically about the involvement of alternative splicing in the formation of macroscopic metastases. Our study investigates transcript isoform changes that characterize tumors of different abilities to form growing metastases. METHODS AND FINDINGS: To identify alternative splicing events (ASEs that are associated with the fully metastatic phenotype in breast cancer, we used Affymetrix Exon Microarrays to profile mRNA isoform variations genome-wide in weakly metastatic (168FARN and 4T07 and highly metastatic (4T1 mammary carcinomas. Statistical analysis identified significant expression changes in 7606 out of 155,994 (4% exons and in 1725 out of 189,460 (1% intronic regions, which affect 2623 out of 16,654 (16% genes. These changes correspond to putative alternative isoforms-several of which are novel-that are differentially expressed between tumors of varying metastatic phenotypes. Gene pathway analysis showed that 1224 of genes expressing alternative isoforms were involved in cell growth, cell interactions, cell proliferation, cell migration and cell death and have been previously linked to cancers and genetic disorders. We chose ten predicted splice variants for RT-PCR validation, eight of which were successfully confirmed (MED24, MFI2, SRRT, CD44, CLK1 and HNRNPH1. These include three novel intron retentions in CD44, a gene in which isoform variations have been previously associated with the metastasis of several cancers. CONCLUSION: Our findings reveal that various genes are differently spliced and/or expressed in association with the metastatic phenotype of tumor cells. Identification of

  13. Towards meeting the research needs of Australian cancer consumers

    Directory of Open Access Journals (Sweden)

    Saunders Carla

    2012-12-01

    Full Text Available Abstract Background There is a growing amount of literature to support the view that active involvement in research by consumers, especially informed and networked consumers, benefits the quality and direction of research itself, the research process and, most importantly, people affected by cancer. Our exploratory project focuses on identifying their priorities and developing a process to assess the research needs of Australian cancer consumers which may be useful beyond the cancer scenario. Methods This project was consumer initiated, developed and implemented, with the assistance of a leading Australian cancer consumer advocacy group, Cancer Voices NSW (CVN. Such direct involvement is unusual and ensures that the priorities identified, and the process itself, are not influenced by other interests, regardless how well-intentioned they may be. The processes established, and data collection via a workshop, followed by a questionnaire to confirm and prioritise findings, and comparison with a similar UK exercise, are detailed in this paper. Results Needs across five topic areas reflecting cancer control domains (prevention and risk; screening and diagnosis; treatment; survivorship; and end of life were identified. Cancer consumers high priority research needs were found to be: earlier diagnosis of metastatic cancers; the extent of use of best practice palliative care guidelines; identifying barriers to cancer risk behaviour change; and environmental, nutrition and lifestyle risk factors for people with cancer. A process for identifying consumers’ research priorities was developed and applied; this may be useful for further investigation in this under-studied area. Conclusion The findings provide a model for developing a consumer derived research agenda in Australia which can be used to inform the strategic direction of cancer research. Consumers have been seeking a workable method to achieve this and have worked in collaboration with a major

  14. Increased rate change over time of a sphincter-saving procedure for lower rectal cancer

    Institute of Scientific and Technical Information of China (English)

    WU Xiao-jian; WANG Jian-ping; WANG Lei; HE Xiao-sheng; ZOU Yi-feng; LIAN Lei; ZHANG Long-juan; LAN Ping

    2008-01-01

    Background Total mesorectal excision(TME)has increased the rate of sphincter-preservation(SP)for more patients with low-lying rectal cancer.Here,we analyze the change of sphincter preserving rates in lower rectal cancer and their related factors.Methods We reviewed retrospectively the medical records of 316 patients with lower rectal cancers,1 to 5 cm from the anorectal line,who had surgical resections from August 1994 to November 2005.The 12-year span was divided into 2 periods:period Ⅰ(August 1994-December 1998)and period Ⅱ(January 1999-November 2005),based on the date (January 1999)when standard total mesorectal excision(TME)was introduced.The patients were divided jnto two groups based on the operation:abdominoperineal resection(APR)or SP surgery.SP rates,leakage and other clinicopathological characteristics were compared between the two time periods and between the two different groups.Results The SP rate increased significantly over the 12 years,from 44.9% in period Ⅰ to 76.2% in period Ⅱ(P=0.000).The factors significantly influencing SP included the distance of the tumor from the anorectal line,gender,time period,circumference of intramural spread and histological differentiation (P<0.05).Significant differences were detected between the two time periods in gender,blood transfusion volume and Dukes'stage(P<0.05).The leakage rate was 2.7% in period Ⅰ and 1.3% in period Ⅱ (P>0.05).Conclusions Over the 12-year period of the study the SP rate in rectal cancers 1-5 cm from the anorectal line has increased significantly while the blood transfusion volume has decreased due to the introduction of TME.However,TME had no effect on operating time and leakage rates.

  15. Immunohistochemical and quantitative changes in salivary EGF, amylase and haptocorrin following radiotherapy for oral cancer

    DEFF Research Database (Denmark)

    Christensen, M E; Hansen, H S; Poulsen, Steen Seier;

    1996-01-01

    Epidermal growth factor (EGF), amylase and haptocorrin are molecules produced in the salivary glands. The aim of the present study was to determine immunohistochemical and quantitative alterations in EGF as compared with haptocorrin and amylase following radiotherapy for oral cancer. Changes...... in the salivary secretion of EGF are of interest because of the importance of EGF in mucosal regeneration. Immunohistochemical studies on normal tissue from parotid and submandibular glands have demonstrated EGF in the serous acini with a tendency to single cell expression in the parotid gland. Amylase has been...... found in the serous acini of both the submandibular and parotid glands. Haptocorrin was localized in the duct system of both glands. In the submandibular glands with radiotherapy induced sialoadenitis only very few acini with weak or no staining for EGF and amylase were demonstrated, while no changes...

  16. Changes in regional ventilation and perfusion in lung cancer patients during treatment

    International Nuclear Information System (INIS)

    Patients with central lung cancer and 43 patients with peripheral lung cancer of various sites were examined after surgical intervention on a multichannel unit using 133Xe. The regional distribution of alveolar ventilation and perfusion blood flow were evaluated in the preoperative period as well as at varying times after operation. Statistical analysis of the results has shown that a significant decrease in the ventilation and blood flow is observed in the zone with a focus of lesion in the preoperative period. At the same time even in the preoperative period a compensatory increase in the ventilation and blood flow occurs in the lower zone of the contralateral lung. An increase in the ventilation and blood flow in all the zones of the remaining lung is observed after pulmonectomy, lobectomy does not change pulmonary function and the operated lung does not regenerate its function. Regional perfusion and ventilation are changed in one direction, their ratio and hence the gaseous composition of the blood remain unchanged

  17. Changes in local pulmonary injury up to 48 months after irradiation for lymphoma and breast cancer

    International Nuclear Information System (INIS)

    Purpose: To assess the recovery from early local pulmonary injury after irradiation and to determine whether regional differences exist. Methods: For 110 patients treated for breast cancer or malignant lymphoma, single photon emission computed tomography (SPECT) perfusion and ventilation scans and CT scans were made before, 3, 18, and 48 months after radiotherapy. Dose-effect relations for changes in local perfusion, ventilation, and density were determined for each individual patient using spatially correlated SPECT and CT data sets, for each follow-up period. Average dose-effect relations for both subgroups were determined, as well as dose-effect relations for different regions. Results: In general, partial improvement of local pulmonary injury was observed between 3 and 18 months for each of the three endpoints. After 18 months, no further improvement was seen. Patients with breast cancer and malignant lymphoma showed a similar improvement (except for the perfusion parameter), which was attributed to a recovery from the early radiation response and could not be explained by contraction effects of fibrosis of lung parenchyma. No regional differences in radiosensitivity 18 months after treatment were observed, except for the dorsal versus ventral region. This difference was attributed to a gravity-related effect in the measuring procedure. Conclusion: For all patients, a partial recovery from early local perfusion, ventilation, and density changes, was seen between 3 and 18 months after radiotherapy. After 18 months, local lung function did not further improve (lymphoma patients)

  18. Flow-cytometric analysis of changes of OKT6+-lymphocytes in the blood of cancer patients during radiation therapy

    International Nuclear Information System (INIS)

    In this study, we report a clinical application of a rapid flow-cytometric immuno-fluorescence method for studying OKT6+-lymphocytes in whole blood by using monoclonal antibody OKT6. Changes in the relative percentages and absolute counts of OKT6+-lymphocytes during radiotherapy of cancer patients were evaluated by this method. In a study of 112 samples from 47 cases, the elevation of OKT6+-lymphocyte level was observed in 10 samples from 9 patients with primary lung cancer or uterine cancer. About 18 cases with lung cancer, the elevation of OKT6+-lymphocyte level was observed in 7 patients. And 5 of these 7 patients did not so respond to radiation therapy. In contrast, the continuous low level of OKT6+-lymphocyte was observed in patients with good response. OKT6+-lymphocyte level could be a valuable parameter for evaluating alterations of immune responses in cancer patients during radiotherapy. (author)

  19. Kentucky Teen Institute: Results of a 1-Year, Health Advocacy Training Intervention for Youth.

    Science.gov (United States)

    King, Kristi M; Rice, Jason A; Steinbock, Stacie; Reno-Weber, Ben; Okpokho, Ime; Pile, Amanda; Carrico, Kelly

    2015-11-01

    The Kentucky Teen Institute trains youth throughout the state to advocate for policies that promote health in their communities. By evaluating two program summits held at universities, regularly scheduled community meetings, ongoing technical support, and an advocacy day at the state Capitol, the aims of this study were to assess the impact of the intervention on correlates of youths' advocacy intentions and behaviors and to assess youth participants' and other key stakeholders' perceptions of the intervention. An ecological model approach and the theory of planned behavior served as theoretical frameworks from which pre-post, one-group survey and qualitative data were collected (June 2013-June 2014). An equal number of low-income and non-low-income youth representing five counties participated in the Summer Summit pretest (n = 24) and Children's Advocacy Day at the Capitol posttest (n = 14). Survey data revealed that youths' attitude toward advocacy, intentions to advocate, and advocacy behaviors all improved over the intervention. Observations, interviews, a focus group, and other written evaluations identified that the youths', as well as their mentors' and advocacy coaches', confidence, communities' capacity, and mutually beneficial mentorship strengthened. Stronger public speaking skills, communication among the teams, and other recommendations for future advocacy interventions are described. PMID:26009558

  20. A Public Policy Advocacy Project to Promote Food Security: Exploring Stakeholders' Experiences.

    Science.gov (United States)

    Atkey, Kayla M; Raine, Kim D; Storey, Kate E; Willows, Noreen D

    2016-09-01

    To achieve food security in Canada, comprehensive approaches are required, which involve action at the public policy level. This qualitative study explored the experiences of 14 stakeholders engaging in a 9-month participatory public policy advocacy project to promote community food security in the province of Alberta through the initiation of a campaign to develop a Universal School Food Strategy. Through this exploration, four main themes were identified; a positive and open space to contribute ideas, diversity and common ground, confidence and capacity, and uncertainty. Findings from this study suggest that the participatory advocacy project provided a positive and open space for stakeholders to contribute ideas, through which the group was able to narrow its focus and establish a goal for advocacy. The project also seems to have contributed to the group's confidence and capacity to engage in advocacy by creating a space for learning and knowledge sharing, though stakeholders expressed uncertainty regarding some aspects of the project. Findings from this study support the use of participatory approaches as a strategy for facilitating engagement in public policy advocacy and provide insight into one group's advocacy experience, which may help to inform community-based researchers and advocates in the development of advocacy initiatives to promote community food security elsewhere.

  1. A Public Policy Advocacy Project to Promote Food Security: Exploring Stakeholders' Experiences.

    Science.gov (United States)

    Atkey, Kayla M; Raine, Kim D; Storey, Kate E; Willows, Noreen D

    2016-09-01

    To achieve food security in Canada, comprehensive approaches are required, which involve action at the public policy level. This qualitative study explored the experiences of 14 stakeholders engaging in a 9-month participatory public policy advocacy project to promote community food security in the province of Alberta through the initiation of a campaign to develop a Universal School Food Strategy. Through this exploration, four main themes were identified; a positive and open space to contribute ideas, diversity and common ground, confidence and capacity, and uncertainty. Findings from this study suggest that the participatory advocacy project provided a positive and open space for stakeholders to contribute ideas, through which the group was able to narrow its focus and establish a goal for advocacy. The project also seems to have contributed to the group's confidence and capacity to engage in advocacy by creating a space for learning and knowledge sharing, though stakeholders expressed uncertainty regarding some aspects of the project. Findings from this study support the use of participatory approaches as a strategy for facilitating engagement in public policy advocacy and provide insight into one group's advocacy experience, which may help to inform community-based researchers and advocates in the development of advocacy initiatives to promote community food security elsewhere. PMID:27199148

  2. Kentucky Teen Institute: Results of a 1-Year, Health Advocacy Training Intervention for Youth.

    Science.gov (United States)

    King, Kristi M; Rice, Jason A; Steinbock, Stacie; Reno-Weber, Ben; Okpokho, Ime; Pile, Amanda; Carrico, Kelly

    2015-11-01

    The Kentucky Teen Institute trains youth throughout the state to advocate for policies that promote health in their communities. By evaluating two program summits held at universities, regularly scheduled community meetings, ongoing technical support, and an advocacy day at the state Capitol, the aims of this study were to assess the impact of the intervention on correlates of youths' advocacy intentions and behaviors and to assess youth participants' and other key stakeholders' perceptions of the intervention. An ecological model approach and the theory of planned behavior served as theoretical frameworks from which pre-post, one-group survey and qualitative data were collected (June 2013-June 2014). An equal number of low-income and non-low-income youth representing five counties participated in the Summer Summit pretest (n = 24) and Children's Advocacy Day at the Capitol posttest (n = 14). Survey data revealed that youths' attitude toward advocacy, intentions to advocate, and advocacy behaviors all improved over the intervention. Observations, interviews, a focus group, and other written evaluations identified that the youths', as well as their mentors' and advocacy coaches', confidence, communities' capacity, and mutually beneficial mentorship strengthened. Stronger public speaking skills, communication among the teams, and other recommendations for future advocacy interventions are described.

  3. Igniting the fire within: a primer on political advocacy for pharmacy professionals.

    Science.gov (United States)

    Gohlke, Angela L; Murphy, Katherine M; Cannell, Megan E; Ray, David B; Burnworth, Melinda J

    2013-06-01

    Due to the expanding role of pharmacy in health care, it is imperative that pharmacy professionals work together to advocate for the profession. An English-language only literature search was conducted of the PubMed and Medline databases using the key words advocacy, grassroots, political action committee, lobbying, politics, political action, legislation, letter writing, pharmacy, pharmacist, Capitol Hill. Up-to-date information regarding pharmacy-specific advocacy was limited and difficult to locate. Information from the literature search was supplemented with interviews of professionals actively engaged in advocacy, personal experience, and Web sites of national pharmacy organizations. This primer ignites the fire for political advocacy within pharmacy professionals by reinforcing the significant impact that advocacy has on the profession and by providing information on how to become involved. The primer provides a comprehensive "pocket guide" of resources combined into an easy-to-use reference for pharmacy professionals and outlines a structured approach on how to become a pharmacy advocate, ranging from a minimal level of involvement to master political activist, and to promote interest among pharmacy professionals to become more engaged with advocacy. Even a small act of advocacy or volunteerism can transform a spark into a raging fire. PMID:23553545

  4. Health behavior changes following breast cancer treatment: a qualitative comparison among Chinese American, Korean American, and Mexican American survivors.

    Science.gov (United States)

    Lim, Jung-won; Gonzalez, Patricia; Wang-Letzkus, Ming F; Baik, Okmi; Ashing-Giwa, Kimlin T

    2013-05-01

    This study explored how Chinese American, Korean American, and Mexican American women modify their health behaviors following breast cancer treatment and identified motivators and barriers that influence their changes. An exploratory, descriptive, qualitative study was undertaken using six focus groups. Discussions were transcribed and translated for content analysis. Significant differences among the ethnic groups were noted in the following health behavior practices which were most commonly stated as changed behaviors after a breast cancer diagnosis: 1) eating habits, 2) physical activity, 3) alternative medicine, 4) sleeping, 5) social activity, 6) weight control, and 7) alcohol consumption. Family, financial concerns, environment, and religious faith were commonly mentioned as motivators of and/or barriers to changes in health behaviors. Findings provide insight into different perspectives related to changes in health behaviors by ethnicity, which is critical for developing culturally tailored behavioral interventions to improve underserved breast cancer survivors' quality of life and to reduce health disparities.

  5. Comparing Cystatin C Changes as a Measure of Renal Function Before and After Radiotherapy in Patients with Stomach Cancer

    OpenAIRE

    Ahmad Ameri; Asadollah Alidoosti; Khosro Mojir Sheybani; Farnaz Taslimi; Morteza Tabatabaiefar; Maryam Mirzaie Moghadam; Hooshang Amir Rasouli; Pedram Fadavi; Shahrzad Aref

    2012-01-01

    The objective of this study was to determine and compare Cystatin C changes before and after radiotherapy in patients with stomach cancer who were candidate for radiotherapy. This study was conducted as a prospective cohort one. Eighteen patients with definite diagnosis of stomach cancer under treatment by radiotherapy who presented to Radiotherapy-Oncology Center of Imam Hossein Hospital, Tehran-Iran, and the treatment in all cases was simultaneous chemoradiation with Xeloda were included. I...

  6. The Effect of Psychological Intervention on Personality Change, Coping, and Psychological Distress of Japanese Primary Breast Cancer Patients

    OpenAIRE

    Maeda, Takako; Kurihara, Hiroko; Morishima, Isamu; MUNAKATA, Tsunetsugu

    2008-01-01

    The purpose of this study is to estimate the effectiveness of psychological intervention on personality change, enhancing perceived emotional support, and, ultimately, assisting in the adaptive coping and psychological well-being of Japanese primary breast cancer patients. The intervention consists of 3 sessions that include providing medical and psychological information and counseling using the structured association technique. The participants were 28 primary breast cancer patients (14 for...

  7. Client-Centered Advocacy: Every Occupational Therapy Practitioner's Responsibility to Understand Medical Necessity.

    Science.gov (United States)

    Stover, Alyson D

    2016-01-01

    Occupational therapy practitioners must advocate for clients in multiple ways. The Occupational Therapy Practice Framework: Domain and Process as well as the Occupational Therapy Code of Ethics lend support to advocacy. Recognizing one's responsibility to provide advocacy for clients is different from knowing how to provide that advocacy. One aspect of health care affected by the Patient Protection and Affordable Care Act (ACA) is the definition and implementation of medical necessity. This article outlines some major concepts around medical necessity, particularly in relation to the passage of the ACA, and outlines guidance on how to advocate effectively to meet both individual and community needs. PMID:27548855

  8. Cancer patients' experience of positive and negative changes due to the illness : relationships with psychological well-being, coping, and goal reengagement

    NARCIS (Netherlands)

    Schroevers, Maya J.; Kraaij, Vivian; Garnefski, Nadia

    2011-01-01

    Objective: Most studies in cancer patients on psychological changes focused on positive changes (so-called 'posttraumatic growth'), with surprisingly little attention on the possibility that patients may experience both positive and negative changes. This study investigated the relationship between

  9. Early hematologic changes during prostate cancer radiotherapy predictive for late urinary and bowel toxicity

    Energy Technology Data Exchange (ETDEWEB)

    Pinkawa, Michael; Djukic, Victoria; Klotz, Jens; Holy, Richard; Eble, Michael J. [RWTH Aachen University, Department of Radiation Oncology, Aachen (Germany); Ribbing, Carolina [RWTH Aachen University, Department of Diagnostic and Interventional Radiology, Aachen (Germany)

    2015-10-15

    The primary objective of the study was to identify early hematologic changes predictive for radiotherapy (RT)-associated genitourinary and gastrointestinal toxicity. In a group of 91 prostate cancer patients presenting for primary (n = 51) or postoperative (n = 40) curative RT, blood samples (blood count, acute phase proteins, and cytokines) were analyzed before (T1), three times during (T2-T4), and 6-8 weeks after (T5) radiotherapy. Before RT (baseline), on the last day (acute toxicity), a median of 2 months and 16 months (late toxicity) after RT, patients responded to a validated questionnaire (Expanded Prostate Cancer Index Composite). Acute score changes > 20 points and late changes > 10 points were considered clinically relevant. Radiotherapy resulted in significant changes of hematologic parameters, with the largest effect on lymphocytes (mean decrease of 31-45 %) and significant dependence on target volume. C-reactive protein (CRP) elevation > 5 mg/l and hemoglobin level decrease ≥ 5 G/1 at T2 were found to be independently predictive for acute urinary toxicity (p < 0.01, respectively). CRP elevation was predominantly detected in primary prostate RT (p = 0.02). Early lymphocyte level elevation ≥ 0.3G/l at T2 was protective against late urinary and bowel toxicity (p = 0.02, respectively). Other significant predictive factors for late bowel toxicity were decreasing hemoglobin levels (cut-off ≥ 5 G/l) at T2 (p = 0.04); changes of TNF-α (tumor necrosis factor; p = 0.03) and ferritin levels (p = 0.02) at T5. All patients with late bowel toxicity had interleukin (IL)-6 levels < 1.5 ng/l at T2 (63 % without; p = 0.01). Early hematologic changes during prostate cancer radiotherapy are predictive for late urinary and bowel toxicity. (orig.) [German] Das primaere Ziel der Studie war die Identifikation von fruehen haematologischen Veraenderungen mit praediktiver Bedeutung fuer radiotherapieassoziierte genitourinale und gastrointestinale Toxizitaet. In einer

  10. Cancer

    Science.gov (United States)

    ... Blood tests (which look for chemicals such as tumor markers) Bone marrow biopsy (for lymphoma or leukemia) Chest ... the case with skin cancers , as well as cancers of the lung, breast, and colon. If the tumor has spread ...

  11. Cancer

    Science.gov (United States)

    Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms ... be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors ...

  12. The changing epidemiology of Asian digestive cancers: From etiologies and incidences to preventive strategies.

    Science.gov (United States)

    Wu, Chun-Ying; Lin, Jaw-Town

    2015-12-01

    Digestive cancers are a major health burden in Asia. Due to the presence of similar "infection-inflammation-cancer" pathways in the carcinogenesis process, eradicating infective pathogens or attenuating relevant inflammatory signaling pathways may reduce digestive cancer incidences and improve patient outcomes. The aim of this paper is to review the recent evidence regarding the epidemiology of three major digestive cancers in Asia: stomach cancer, liver cancer, and colorectal cancer. We focused on the incidence trends, the major etiologies, and especially the potential preventive strategies.

  13. Neural Changes following Behavioral Activation for a Depressed Breast Cancer Patient: A Functional MRI Case Study

    Directory of Open Access Journals (Sweden)

    Michael J. Gawrysiak

    2012-01-01

    Full Text Available Functional neuroimaging is an innovative but at this stage underutilized method to assess the efficacy of psychotherapy for depression. Functional magnetic resonance imaging (fMRI was used in this case study to examine changes in brain activity in a depressed breast cancer patient receiving an 8-session Behavioral Activation Treatment for Depression (BATD, based on the work of Hopko and Lejuez (2007. A music listening paradigm was used during fMRI brain scans to assess reward responsiveness at pre- and posttreatment. Following treatment, the patient exhibited attenuated depression and changes in blood oxygenation level dependence (BOLD response in regions of the prefrontal cortex and the subgenual cingulate cortex. These preliminary findings outline a novel means to assess psychotherapy efficacy and suggest that BATD elicits functional brain changes in areas implicated in the pathophysiology of depression. Further research is necessary to explore neurobiological mechanisms of change in BATD, particularly the potential mediating effects of reward responsiveness and associated brain functioning.

  14. Chronological Changes of Quality of Life in Long-Term Survivors after Gastrectomy for Gastric Cancer

    Science.gov (United States)

    Yu, Wansik; Park, Ki Bum; Chung, Ho Young; Kwon, Oh Kyoung; Lee, Seung Soo

    2016-01-01

    Purpose A few studies have prospectively evaluated changes in quality of life (QoL) after surgery in short-term survivors; however, no prospective study has evaluated the longitudinal changes in QoL in long-terms survivors. We prospectively evaluated the chronological changes in QoL after a gastrectomy over a 5-year postoperative period in a large group of patients. Materials and Methods QoL data from the European Organization for Research and Treatment of Cancer QLQ-C30 and the QLQ-STO22 questionnaires were obtained from 254 patients who completed the entire series of QoL assessments preoperatively and at 1, 2, 3, 4, and 5 years after surgery. Results There was no statistically significant change in global health status/QoL during the 5-year postoperative period. Decreases in QoL from upper gastrointestinal symptoms including diarrhea (p physical functioning (p physical functioning, role functioning, and body image. In addition, patients should be encouraged to preserve self-esteem and maintain social activity. PMID:27004956

  15. Changes in frequency of recall recommendations of examinations depicting cancer with the availability of either priors or digital breast tomosynthesis

    Science.gov (United States)

    Hakim, Christiane M.; Bandos, Andriy I.; Ganott, Marie A.; Catullo, Victor J.; Chough, Denise M.; Kelly, Amy E.; Shinde, Dilip D.; Sumkin, Jules H.; Wallace, Luisa P.; Nishikawa, Robert M.; Gur, David

    2016-03-01

    Performance changes in a binary environment when using additional information is affected only when changes in recommendations are made due to the additional information in question. In a recent study, we have shown that, contrary to general expectation, introducing prior examinations improved recall rates, but not sensitivity. In this study, we assessed cancer detection differences when prior examinations and/or digital breast tomosynthesis (DBT) were made available to the radiologist. We identified a subset of 21 cancer cases with differences in the number of radiologists who recalled these cases after reviewing either a prior examination or DBT. For the cases with differences in recommendations after viewing either priors or DBT, separately, we evaluated the total number of readers that changed their recommendations, regardless of the specific radiologist in question. Confidence intervals for the number of readers and a test for the hypothesis of no difference was performed using the non-parameteric bootstrap approach addressing both case and reader-related sources of variability by resampling cases and readers. With the addition of priors, there were 14 cancer cases (out of 15) where the number of "recalling radiologists" decreased. With the addition of DBT, the number of "recalling radiologists" decreased in only five cases (out of 15) while increasing in the remaining 9 cases. Unlike most new approaches to breast imaging DBT seems to improve both recall rates and cancer detection rates. Changes in recommendations were noted by all radiologists for all cancers by type, size, and breast density.

  16. Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer

    Directory of Open Access Journals (Sweden)

    Smith Jeffrey W

    2007-06-01

    Full Text Available Abstract Background The lipogenic enzyme fatty acid synthase (FAS is up-regulated in a wide variety of cancers, and is considered a potential metabolic oncogene by virtue of its ability to enhance tumor cell survival. Inhibition of tumor FAS causes both cell cycle arrest and apoptosis, indicating FAS is a promising target for cancer treatment. Results Here, we used gene expression profiling to conduct a global study of the cellular processes affected by siRNA mediated knockdown of FAS in MDA-MB-435 mammary carcinoma cells. The study identified 169 up-regulated genes (≥ 1.5 fold and 110 down-regulated genes (≤ 0.67 fold in response to knockdown of FAS. These genes regulate several aspects of tumor function, including metabolism, cell survival/proliferation, DNA replication/transcription, and protein degradation. Quantitative pathway analysis using Gene Set Enrichment Analysis software further revealed that the most pronounced effect of FAS knockdown was down-regulation in pathways that regulate lipid metabolism, glycolysis, the TCA cycle and oxidative phosphorylation. These changes were coupled with up-regulation in genes involved in cell cycle arrest and death receptor mediated apoptotic pathways. Conclusion Together these findings reveal a wide network of pathways that are influenced in response to FAS knockdown and provide new insight into the role of this enzyme in tumor cell survival and proliferation.

  17. Changes in Bone Mineral Density in Uterine Cervical Cancer Patients After Radiation Therapy

    International Nuclear Information System (INIS)

    Purpose: To prospectively investigate the changes in bone mineral density (BMD) after pelvic radiation therapy in patients with uterine cervical cancer. Methods and Materials: Of 52 cervical cancer patients who received pelvic RT in our university hospital between 2009 and 2011, 46 patients without recurrence and who were followed up for more than 12 months were included in the study. The BMD of the irradiated region and nonirradiated regions, serum estradiol, tartrate-resistant acid phosphatase-5b, and N-terminal cross-linking telopeptide of collagen 1 were measured before, at 3 months after, and at 12 months after RT. The patient cohort was divided into 2 groups according to estradiol level before RT, and the groups were defined as postmenopausal (2 before RT and 0.746 and 0.841 g/cm2 12 months after RT, respectively. Significant decreases were observed in both groups (P2 before RT and were significantly decreased to 0.706 and 0.921 g/cm2 12 months after RT (P<.01 and P<.05, respectively). Estradiol significantly decreased 3 months after RT, whereas tartrate-resistant acid phosphatase-5b and N-terminal cross-linking telopeptide of collagen 1 continued to increase over time in the premenopausal group. Conclusions: A decrease in BMD in the irradiated region after RT was observed within 1 year, regardless of menopausal status. Furthermore, in premenopausal patients, pelvic RT caused a decrease in systemic BMD

  18. Expression changes in the stroma of prostate cancer predict subsequent relapse.

    Directory of Open Access Journals (Sweden)

    Zhenyu Jia

    Full Text Available Biomarkers are needed to address overtreatment that occurs for the majority of prostate cancer patients that would not die of the disease but receive radical treatment. A possible barrier to biomarker discovery may be the polyclonal/multifocal nature of prostate tumors as well as cell-type heterogeneity between patient samples. Tumor-adjacent stroma (tumor microenvironment is less affected by genetic alteration and might therefore yield more consistent biomarkers in response to tumor aggressiveness. To this end we compared Affymetrix gene expression profiles in stroma near tumor and identified a set of 115 probe sets for which the expression levels were significantly correlated with time-to-relapse. We also compared patients that chemically relapsed shortly after prostatectomy (<1 year, and patients that did not relapse in the first four years after prostatectomy. We identified 131 differentially expressed microarray probe sets between these two categories. 19 probe sets (15 genes overlapped between the two gene lists with p<0.0001. We developed a PAM-based classifier by training on samples containing stroma near tumor: 9 rapid relapse patient samples and 9 indolent patient samples. We then tested the classifier on 47 different samples, containing 90% or more stroma. The classifier predicted the risk status of patients with an average accuracy of 87%. This is the first general tumor microenvironment-based prognostic classifier. These results indicate that the prostate cancer microenvironment exhibits reproducible changes useful for predicting outcomes for patients.

  19. Echographic characteristics of structural and functional changes in the antrum cancer

    International Nuclear Information System (INIS)

    The character of structural and functional changes in the antrum was studied in 18 patients with cancer using transabdominal ultrasound. Wall layers of stomach were not differentiated in all the patients with stomach cancer. The thickness of the involved segments was 9,8+-2,7 mm, diameter of the pylorus - 8,2+-0,9 mm, speed of evacuation - 31+-3 cm/s, fasting stomach volume 39+-6 ml in patients with compensated pyloricstenosis. Stomach wall thickness was 19,2=-3,8 mm, diameter of the pylorus -4,5+-1,2 mm, speed of evacuation 34+-5 cm/s, the amount of content on an emptystomach 137+-31 ml among the patients with subcompensated pyloricstenosis.The thickness of the affected area of the output of the stomach was 31,2+-4,8 mm, diameter of the pylorus - 2,4+-0,9 mm, the residual volume of the stomach on an empty stomach - 335+-32 ml in patients with decompensated pyloricstenosis

  20. Family health advocacy: an empowerment model for pregnant and parenting African American women in rural communities.

    Science.gov (United States)

    Baffour, Tiffany D; Jones, Maurine A; Contreras, Linda K

    2006-01-01

    The model of family health advocacy built firmly upon principles of empowerment theory seeks to help individuals, families, and communities to improve their circumstances by incorporating multiple levels of intervention. The goal of family health advocacy is to improve the well-being of pregnant women and mothers of children younger than 2 years by providing social support and health education about risk factors related to infant mortality and prematurity. This program primarily targets rural African American women, a group at high risk. Advocacy and referral for needed medical and social services are provided. This article presents a comprehensive model of health advocacy, including social marketing strategies, recruitment efforts, and curriculum development. PMID:16775472

  1. Nursing beliefs and actions in exercising patient advocacy in a hospital context

    Directory of Open Access Journals (Sweden)

    Jamila Geri Tomaschewski Barlem

    2015-10-01

    Full Text Available AbstractOBJECTIVEAnalyzing beliefs and actions of nurses in exercising patient advocacy in a hospital context.METHODA quantitative cross-sectional exploratory and descriptive study, conducted with 153 nurses from two hospitals in southern Brazil, one public and one philanthropic, by applying Protective Nursing Advocacy Scale - Brazilian version. Data were analyzed using descriptive statistics and analysis of variance.RESULTSNurses believe they are advocating for patients in their workplaces, and agree that they should advocate, especially when vulnerable patients need their protection. Personal values and professional skills have been identified as major sources of support for the practice of advocacy.CONCLUSIONNurses do not disagree nor agree that advocating for patients in their working environments can bring them negative consequences. It is necessary to recognize how the characteristics of public and private institutions have helped or not helped in exercising patient advocacy by nurses.

  2. Explaining variation in gun control policy advocacy tactics among local organizations.

    Science.gov (United States)

    Zakocs, Ronda C; Earp, Jo Anne L

    2003-06-01

    The goal of this study was to determine how well four organizational characteristics (structure, resources, motivation, or political capacity) explained local organizations' use of a variety of advocacy tactics aimed at promoting state gun control laws. In 1998, 679 local organizations were identified as potentially active on state gun control issues; a questionnaire was mailed to each group's leader. Seventy-nine percent (n = 538) responded to the survey, with 81% (n = 207) of eligible organizations completing questionnaires. The four organizational characteristics explained approximately half the variation in local groups' use of a wide range of advocacy tactics. Organizations with stronger motivation to address the gun control issue and greater political capacity engaged in more diverse gun control advocacy tactics; the authors found organizational structure and resources unlikely to be related. Leaders of advocacy organizations should consider ways to encourage members' motivations on the issue while fostering greater capacity for political action. PMID:19731501

  3. Coleman Advocates for Children And Youth: a pioneering child advocacy organization (1974-2008).

    Science.gov (United States)

    Carnochan, Sarah; Austin, Michael J

    2011-01-01

    Coleman Advocates for Youth and Children is a pioneering 30-year-old child advocacy organization founded by several affluent community members and children's service professionals to stop housing abused and neglected children in juvenile hall. Today, low-income youth and parents in families of color are now assuming leadership in developing a unique hybrid approach that integrates community organizing with more traditional child advocacy strategies and focuses on increasing affordable housing and improving the city's educational system. The strategies employed by Coleman have also evolved, shifting from insider advocacy with administrative officials to public campaigns targeting the city budget process, to local initiative campaigns, and most recently to electoral politics. This organizational history features the issues mission and structure, leadership, managing issues, advocacy strategies and community relations, and funding.

  4. Transcriptomic changes in human breast cancer progression as determined by serial analysis of gene expression

    International Nuclear Information System (INIS)

    Genomic and transcriptomic alterations affecting key cellular processes such us cell proliferation, differentiation and genomic stability are considered crucial for the development and progression of cancer. Most invasive breast carcinomas are known to derive from precursor in situ lesions. It is proposed that major global expression abnormalities occur in the transition from normal to premalignant stages and further progression to invasive stages. Serial analysis of gene expression (SAGE) was employed to generate a comprehensive global gene expression profile of the major changes occurring during breast cancer malignant evolution. In the present study we combined various normal and tumor SAGE libraries available in the public domain with sets of breast cancer SAGE libraries recently generated and sequenced in our laboratory. A recently developed modified t test was used to detect the genes differentially expressed. We accumulated a total of approximately 1.7 million breast tissue-specific SAGE tags and monitored the behavior of more than 25,157 genes during early breast carcinogenesis. We detected 52 transcripts commonly deregulated across the board when comparing normal tissue with ductal carcinoma in situ, and 149 transcripts when comparing ductal carcinoma in situ with invasive ductal carcinoma (P < 0.01). A major novelty of our study was the use of a statistical method that correctly accounts for the intra-SAGE and inter-SAGE library sources of variation. The most useful result of applying this modified t statistics beta binomial test is the identification of genes and gene families commonly deregulated across samples within each specific stage in the transition from normal to preinvasive and invasive stages of breast cancer development. Most of the gene expression abnormalities detected at the in situ stage were related to specific genes in charge of regulating the proper homeostasis between cell death and cell proliferation. The comparison of in situ lesions

  5. Polarized Raman spectroscopy unravels the biomolecular structural changes in cervical cancer

    Science.gov (United States)

    Daniel, Amuthachelvi; Prakasarao, Aruna; Dornadula, Koteeswaran; Ganesan, Singaravelu

    2016-01-01

    Polarized Raman spectroscopy has emerged as a promising technique giving a wealth of information about the orientation and symmetry of bond vibrations in addition to the general chemical information from the conventional Raman spectroscopy. In this regard, polarized Raman Spectroscopic technique was employed to study the changes in the orientation of biomolecules in normal and cancerous conditions. This technique was compared to the conventional Raman spectroscopic technique and was found to yield additional information about the orientation of tyrosine, collagen and DNA. The statistically analyzed depolarization ratios by Linear Discriminant Analysis yielded better accuracy than the statistical results of conventional Raman spectroscopy. Thus, this study reveals that polarized Raman spectroscopy has better diagnostic potential than the conventional Raman spectroscopic technique.

  6. Validity of the Process of Change for Colorectal Cancer Screening Among African Americans

    Science.gov (United States)

    DuHamel, Katherine; Li, Yuelin; Rakowski, William; Samimi, Parisa; Jandorf, Lina

    2013-01-01

    Background Process of change (POC) is a construct of the transtheoretical model that proposes to promote healthy behaviors. Purpose African Americans participate in colorectal cancer (CRC) screening less often than whites, while disease onset is younger, and incidence and mortality from CRC are higher. Methods POC items for CRC screening were administered to 158 African Americans, the majority of whom were female (75.9%) and were not employed (85.4%). Confirmatory factor analysis was used to validate four factors reflecting the POC sub-domains. Results Support of the factor validity of the POC with internal consistency of standardized alpha for the four factors was found. A logistic regression showed predictive validity in predicting current screening stage for two of the four sub-domains. Conclusion These data support the application of the POC to prediction of CRC screening intention among African Americans. PMID:21165726

  7. Pathological steps of cancer-related lymphedema: histological changes in the collecting lymphatic vessels after lymphadenectomy.

    Directory of Open Access Journals (Sweden)

    Makoto Mihara

    Full Text Available INTRODUCTION: To date, an electron microscopy study of the collecting lymphatic vessels has not been conducted to examine the early stages of lymphedema. However, such histological studies could be useful for elucidating the mechanism of lymphedema onset. The aim of this study was to clarify the changes occurring in collecting lymphatic vessels after lymphadenectomy. METHODS: The study was conducted on 114 specimens from 37 patients who developed lymphedema of the lower limbs after receiving surgical treatment for gynecologic cancers and who consulted the University of Tokyo Hospital and affiliated hospitals from April 2009 to March 2011. Lymphatic vessels that were not needed for lymphatico venous anastomosis surgery were trimmed and subsequently examined using electron microscopy and light microscopy. RESULTS: Based on macroscopic findings, the histochemical changes in the collecting lymphatic vessels were defined as follows: normal, ectasis, contraction, and sclerosis type (NECST. In the ectasis type, an increase in endolymphatic pressure was accompanied by a flattening of the lymphatic vessel endothelial cells. In the contraction type, smooth muscle cells were transformed into synthetic cells and promoted the growth of collagen fibers. In the sclerosis type, fibrous elements accounted for the majority of the components, the lymphatic vessels lost their transport and concentrating abilities, and the lumen was either narrowed or completely obstructed. CONCLUSIONS: The increase in pressure inside the collecting lymphatic vessels after lymphadenectomy was accompanied by histological changes that began before the onset of lymphedema.

  8. Pulmonary Changes After Radiotherapy for Conservative Treatment of Breast Cancer: A Prospective Study

    International Nuclear Information System (INIS)

    Purpose: Radiotherapy (RT) after conservative surgery for breast cancer involves part of the pulmonary parenchyma with a potential detrimental effect of reducing the normal functional reserve. Such an effect deserves to be studied in depth, considering the given long life expectancy of these women. We prospectively analyzed high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs) with correlation with dosimetric data from RT. Methods and Materials: Lung HRCT and PFTs were performed in 41 women who had undergone conservative surgery for breast cancer before and 3 and 9 months after postoperative RT. The PFTs included forced vital capacity, forced expiratory volume in 1 s, total lung capacity, maximal expiratory flow at 50% and 25% of vital capacity, and the diffusion capacity of carbon monoxide. HRCT was matched with the RT treatment plan images to analyze the dosimetric correlation. Results: At 3 months after RT, the lung alterations were classified at HRCT as follows: 46.3% were Grade 1, 24.4% Grade 2, and 7.3% Grade 3, and at 9 months, 58.5% were Grade 1, 19.5% Grade 2, and 0% Grade 3. The PFTs showed a significant decrease at 3 months, with only partial recovery at 9 months. Chemotherapy, but not hormonal therapy, was associated with PFT changes. The grade of fibrosis increased with increasing lung volume treated to a dose ≥25 Gy. Conclusion: Lung changes, mainly related to damage to the alveolar-capillary barrier and smallest airway ramifications, were observed at 3 months, with only partial recovery at 9 months after RT. Minimizing the lung volume receiving ≥25 Gy could reduce pulmonary toxicity

  9. Monitoring longitudinal changes in irradiated head and neck cancer xenografts using diffuse reflectance spectroscopy

    Science.gov (United States)

    Vishwanath, Karthik; Jiang, Shudong; Gunn, Jason R.; Marra, Kayla; Andreozzi, Jacqueline M.; Pogue, Brian W.

    2016-02-01

    Radiation therapy is often used as the preferred clinical treatment for control of localized head and neck cancer. However, during the course of treatment (6-8 weeks), feedback about functional and/or physiological changes within impacted tissue are not obtained, given the onerous financial and/or logistical burdens of scheduling MRI, PET or CT scans. Diffuse optical sensing is well suited to address this problem since the instrumentation can be made low-cost and portable while still being able to non-invasively provide information about vascular oxygenation in vivo. Here we report results from studies that employed an optical fiber-based portable diffuse reflectance spectroscopy (DRS) system to longitudinally monitor changes in tumor vasculature within two head and neck cancer cell lines (SCC-15 and FaDu) xenografted in the flanks of nude mice, in two separate experiments. Once the tumor volumes were 100mm3, 67% of animals received localized (electron beam) radiation therapy in five fractions (8Gy/day, for 5 days) while 33% of the animals served as controls. DRS measurements were obtained from each animal on each day of treatment and then for two weeks post-treatment. Reflectance spectra were parametrized to extract total hemoglobin concentration and blood oxygen-saturation and the resulting time-trends of optical parameters appear to be dissimilar for the two cell-lines. These findings are also compared to previous animal experiments (using the FaDu line) that were irradiated using a photon beam radiotherapy protocol. These results and implications for the use of fiber-based DRS measurements made at local (irradiated) tumor site as a basis for identifying early radiotherapy-response are presented and discussed.

  10. Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers.

    Directory of Open Access Journals (Sweden)

    Yuichi Shiraishi

    Full Text Available Recent studies applying high-throughput sequencing technologies have identified several recurrently mutated genes and pathways in multiple cancer genomes. However, transcriptional consequences from these genomic alterations in cancer genome remain unclear. In this study, we performed integrated and comparative analyses of whole genomes and transcriptomes of 22 hepatitis B virus (HBV-related hepatocellular carcinomas (HCCs and their matched controls. Comparison of whole genome sequence (WGS and RNA-Seq revealed much evidence that various types of genomic mutations triggered diverse transcriptional changes. Not only splice-site mutations, but also silent mutations in coding regions, deep intronic mutations and structural changes caused splicing aberrations. HBV integrations generated diverse patterns of virus-human fusion transcripts depending on affected gene, such as TERT, CDK15, FN1 and MLL4. Structural variations could drive over-expression of genes such as WNT ligands, with/without creating gene fusions. Furthermore, by taking account of genomic mutations causing transcriptional aberrations, we could improve the sensitivity of deleterious mutation detection in known cancer driver genes (TP53, AXIN1, ARID2, RPS6KA3, and identified recurrent disruptions in putative cancer driver genes such as HNF4A, CPS1, TSC1 and THRAP3 in HCCs. These findings indicate genomic alterations in cancer genome have diverse transcriptomic effects, and integrated analysis of WGS and RNA-Seq can facilitate the interpretation of a large number of genomic alterations detected in cancer genome.

  11. Planning for the next generation of public health advocates: evaluation of an online advocacy mentoring program.

    Science.gov (United States)

    O'Connell, Emily; Stoneham, Melissa; Saunders, Julie

    2016-04-01

    Issue addressed Despite being viewed as a core competency for public health professionals, public health advocacy lacks a prominent place in the public health literature and receives minimal coverage in university curricula. The Public Health Advocacy Institute of Western Australia (PHAIWA) sought to fill this gap by establishing an online e-mentoring program for public health professionals to gain knowledge through skill-based activities and engaging in a mentoring relationship with an experienced public health advocate. This study is a qualitative evaluation of the online e-mentoring program. Methods Semi-structured interviews were conducted with program participants at the conclusion of the 12-month program to examine program benefits and determine the perceived contribution of individual program components to overall advocacy outcomes. Results Increased mentee knowledge, skills, level of confidence and experience, and expanded public health networks were reported. Outcomes were dependent on participants' level of commitment, time and location barriers, mentoring relationship quality, adaptability to the online format and the relevance of activities for application to participants' workplace context. Program facilitators had an important role through the provision of timely feedback and maintaining contact with participants. Conclusion An online program that combines public health advocacy content via skill-based activities with mentoring from an experienced public health advocate is a potential strategy to build advocacy capacity in the public health workforce. So what? Integrating advocacy as a core component of professional development programs will help counteract current issues surrounding hesitancy by public health professionals to proactively engage in advocacy, and ensure that high quality, innovative and effective advocacy leadership continues in the Australian public health workforce.

  12. Management, leadership and user control in self-advocacy: an English case study

    OpenAIRE

    Tilley, Elizabeth

    2013-01-01

    This paper presents findings from a qualitative research project on an English self-advocacy organization. In light of recent political and economic developments that have threatened the sustainability of a number of self-advocacy groups for people with intellectual disabilities, I seek to explore how one particular organization managed to survive and grow. In particular, the paper explores themes of management, leadership, and user control, linking these to external perceptions about self-ad...

  13. “We Are Not Really Marketing Mental Health”: Mental Health Advocacy in Zimbabwe

    Science.gov (United States)

    Hendler, Reuben; Kidia, Khameer; Machando, Debra; Crooks, Megan; Mangezi, Walter; Abas, Melanie; Katz, Craig; Thornicroft, Graham; Semrau, Maya

    2016-01-01

    Introduction Few people with mental disorders in low and middle-income countries (LMICs) receive treatment, in part because mental disorders are highly stigmatized and do not enjoy priority and resources commensurate with their burden on society. Advocacy has been proposed as a means of building political will and community support for mental health and reducing stigma, but few studies have explored the practice and promise of advocacy in LMICs. Methods We conducted 30 semi-structured interviews with leaders in health and mental health in Zimbabwe to explore key stakeholder perceptions on the challenges and opportunities of the country’s mental health system. We coded the transcripts using the constant comparative method, informed by principles of grounded theory. Few interview questions directly concerned advocacy, yet in our analysis, advocacy emerged as a prominent, cross-cutting theme across participants and interview questions. Results Two thirds of the respondents discussed advocacy, often in depth, returning to the concept throughout the interview and emphasizing their belief in advocacy’s importance. Participants described six distinct components of advocacy: the advocates, to whom they advocate (“targets”), what they advocate for (“asks”), how advocates reach their targets (“access”), how they make their asks (“arguments”), and the results of their advocacy (“outcomes”). Discussion Despite their perception that mental health is widely misunderstood and under-appreciated in Zimbabwe, respondents expressed optimism that strategically speaking out can reduce stigma and increase access to care. Key issues included navigating hierarchies, empowering service users to advocate, and integrating mental health with other health initiatives. Understanding stakeholder perceptions sets the stage for targeted development of mental health advocacy in Zimbabwe and other LMICs. PMID:27607240

  14. Planning for the next generation of public health advocates: evaluation of an online advocacy mentoring program.

    Science.gov (United States)

    O'Connell, Emily; Stoneham, Melissa; Saunders, Julie

    2016-04-01

    Issue addressed Despite being viewed as a core competency for public health professionals, public health advocacy lacks a prominent place in the public health literature and receives minimal coverage in university curricula. The Public Health Advocacy Institute of Western Australia (PHAIWA) sought to fill this gap by establishing an online e-mentoring program for public health professionals to gain knowledge through skill-based activities and engaging in a mentoring relationship with an experienced public health advocate. This study is a qualitative evaluation of the online e-mentoring program. Methods Semi-structured interviews were conducted with program participants at the conclusion of the 12-month program to examine program benefits and determine the perceived contribution of individual program components to overall advocacy outcomes. Results Increased mentee knowledge, skills, level of confidence and experience, and expanded public health networks were reported. Outcomes were dependent on participants' level of commitment, time and location barriers, mentoring relationship quality, adaptability to the online format and the relevance of activities for application to participants' workplace context. Program facilitators had an important role through the provision of timely feedback and maintaining contact with participants. Conclusion An online program that combines public health advocacy content via skill-based activities with mentoring from an experienced public health advocate is a potential strategy to build advocacy capacity in the public health workforce. So what? Integrating advocacy as a core component of professional development programs will help counteract current issues surrounding hesitancy by public health professionals to proactively engage in advocacy, and ensure that high quality, innovative and effective advocacy leadership continues in the Australian public health workforce. PMID:27468984

  15. China's climate-change policy 1988-2011: From zero to hero?

    Energy Technology Data Exchange (ETDEWEB)

    Stensdal, Iselin

    2012-11-01

    This report describes the evolution of China's domestic climate-change policy over the period 1988-2011, using the Advocacy Coalition Framework (ACF) to explore the policy change. Policy development has been gradual, with the most notable change occurring in 2007, when the National Climate Change Programme elevated climate change to a national policy issue. Within the climate-change policy subsystem there emerged an advocacy coalition - the Climate Change Advocacy Coalition - urging that climate change should be taken into consideration in relevant policies. The ACF points to socioeconomic development and the Climate Change Advocacy Coalition's policy-oriented learning as explanations for the development of climate-change policy in China.(auth)

  16. Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Suzanne Miyamoto

    2015-04-01

    Full Text Available Lung cancer is a leading cause of cancer deaths worldwide. Metabolic alterations in tumor cells coupled with systemic indicators of the host response to tumor development have the potential to yield blood profiles with clinical utility for diagnosis and monitoring of treatment. We report results from two separate studies using gas chromatography time-of-flight mass spectrometry (GC-TOF MS to profile metabolites in human blood samples that significantly differ from non-small cell lung cancer (NSCLC adenocarcinoma and other lung cancer cases. Metabolomic analysis of blood samples from the two studies yielded a total of 437 metabolites, of which 148 were identified as known compounds and 289 identified as unknown compounds. Differential analysis identified 15 known metabolites in one study and 18 in a second study that were statistically different (p-values <0.05. Levels of maltose, palmitic acid, glycerol, ethanolamine, glutamic acid, and lactic acid were increased in cancer samples while amino acids tryptophan, lysine and histidine decreased. Many of the metabolites were found to be significantly different in both studies, suggesting that metabolomics appears to be robust enough to find systemic changes from lung cancer, thus showing the potential of this type of analysis for lung cancer detection.

  17. Change in diffusion weighted MRI during liver cancer radiotherapy: Preliminary observations

    Energy Technology Data Exchange (ETDEWEB)

    Eccles, Cynthia L.; Haider, Ehsan A.; Haider, Masoom A.; Fung, Sharon; Lockwood, Gina; Dawson, Laura A. (University of Toronto, Toronto, Ontario (Canada))

    2009-10-15

    Purpose. To evaluate diffusion weighted magnetic resonance imaging (DWI) in liver and liver cancers during and following conformal radiotherapy (RT). To determine the feasibility of using changes in apparent diffusion coefficients (ADC) as a potential surrogate for tumour control or normal tissue injury. Materials and methods. Patients on a six-fraction conformal liver RT protocol underwent DW-MRI at the time of treatment planning, during RT (week one and two) and one month following RT. Diffusion weighted MR images were acquired in exhale breath hold, using b-values of 0 and 600. Regions of interest (ROIs) corresponding to maximal tumour dose, high-dose peri-tumour liver, irradiated normal liver, non-irradiated liver, and spleen were analyzed on ADC maps. Results. Eleven patients (four hepatocellular carcinoma, five liver metastases, two cholangiocarcinoma) were evaluated. The baseline median tumour ADC of 1.56x10-3mm2/sec increased to 1.89x10-3mm2/sec at RT week one, to 1.91x10-3mm2/sec during week two and to 2.01x10-3mm2/sec at one month following treatment (p < 0.0001). Early increases in mean ADC were correlated with higher dose and sustained tumour response, whereas RECIST and volume changes on T2 images were not. Peri-tumour mean ADC also increased, from 1.40x10-3mm2/sec (baseline) to 1.55x10-3mm2/sec (RT week 2) and 1.64 x 10-3mm2/sec (follow-up). Small ADC changes were seen in the irradiated liver, and no significant changes were seen in the un-irradiated liver. Conclusions. Changes in tumour ADC were seen during RT. Larger increases were correlated with higher doses and increased likelihood of response

  18. Lung function changes and complications after lobectomy for lung cancer in septuagenarians

    Directory of Open Access Journals (Sweden)

    Subotic Dragan

    2009-01-01

    Full Text Available Background: In septuagenarians, lobectomy is the preferable operation, with lower morbidity than for pneumonectomy. However, the 1-year impact of lobectomy on lung function has not been well studied in elderly patients. Materials and Methods: Retrospective study including 30 patients 70 years or older (study group, 25 patients with chronic obstructive pulmonary disease (COPD under 70 years (control group 1, and 22 patients under 70 years with normal lung function (control group 2 operated for lung cancer in a 2-year period. The study and control groups were compared related to lung function changes after lobectomy, operative morbidity, and mortality. Results: Postoperative lung function changes in the elderly followed the similar trend as in patients with COPD. There were no significant differences between these two groups related to changes in forced expiratory volume in the first second (FEV 1 and vital capacity (VC. Unlike that, the pattern of the lung function changes in the elderly was significantly different compared with patients with normal lung function. The mean postoperative decrease in FEV 1 was 14.16% in the elderly, compared with a 29.23% decrease in patients with normal lung function ( P < 0.05. In the study and control groups, no patients died within the first 30 postoperative days. The operative morbidity in the elderly group was significantly lower than in patients with COPD (23.3% vs. 60%. Conclusions: The lung function changes after lobectomy in the elderly are similar to those in patients with COPD. The explanation for such a finding needs further investigation. Despite a high proportion of concomitant diseases, the age itself does not carry a prohibitively high risk of operative mortality and morbidity.

  19. Post-radiation changes in oral tissues - An analysis of cancer irradiation cases

    Directory of Open Access Journals (Sweden)

    Jay Ashokkumar Pandya

    2014-01-01

    Full Text Available Introduction: Radiation, commonly employed as neoadjuvant, primary, and adjuvant therapy for head and neck cancer causes numerous epithelial and stromal changes, prominent among which is fibrosis with its early and late consequences. Very little is known about the true nature of the fibrosed tissue and the type of fibers accumulated. Radiotherapy affects the supporting tumor stroma often resulting in a worsening grade of tumor post-radiation. Aim: To study epithelial, neoplastic, stromal, and glandular changes in oral cavity induced by radiation therapy for oral squamous cell carcinoma (OSCC using special stains. Materials and Methods: The study included 27 samples of recurrent OSCC following completion of radiotherapy (recurrence within an average span of 11 months, and 26 non-irradiated cases of OSCC. Patients with a history of combined radiotherapy and chemotherapy were not included in the study. The epithelial changes assessed included epithelial atrophy, apoptosis, necrosis, dysplasia, and neoplasia. The connective tissue was evaluated for amount of fibrosis, quality of fibers (using picrosirius red staining, fibrinous exudate, necrosis, pattern of invasion, vessel wall thickening, and salivary gland changes. The aforementioned changes were assessed using light and polarizing microscopy and tabulated. Statistical Analysis: Epithelial and connective tissue parameters were compared between the irradiated and non-irradiated cases using chi square and t-tests. Results: Epithelial and connective tissue parameters were found to be increased in irradiated patients. Pattern of invasion by tumor cells varied from strands and  cords between the two groups studied. The effect of radiation was seen to reflect on the maturity of fibers and the regularity of their distribution.

  20. Changes in Cervical Cancer FDG Uptake During Chemoradiation and Association With Response

    Energy Technology Data Exchange (ETDEWEB)

    Kidd, Elizabeth A., E-mail: ekidd@stanford.edu [Department of Radiation Oncology, Stanford University, Stanford, California (United States); Thomas, Maria [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri (United States); Siegel, Barry A.; Dehdashti, Farrokh [Alvin J. Siteman Cancer Center, St. Louis, Missouri (United States); Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri (United States); Grigsby, Perry W. [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri (United States); Alvin J. Siteman Cancer Center, St. Louis, Missouri (United States); Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri (United States); Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, Missouri (United States)

    2013-01-01

    Purpose: Previous research showed that pretreatment uptake of F-18 fluorodeoxyglucose (FDG), as assessed by the maximal standardized uptake value (SUV{sub max}) and the variability of uptake (FDG{sub hetero}), predicted for posttreatment response in cervical cancer. In this pilot study, we evaluated the changes in SUV{sub max} and FDG{sub hetero} during concurrent chemoradiation for cervical cancer and their association with post-treatment response. Methods and Materials: Twenty-five patients with stage Ib1-IVa cervical cancer were enrolled. SUV{sub max}, FDG{sub hetero}, and metabolic tumor volume (MTV) were recorded from FDG-positron emission tomography (PET)/computed tomography (CT) scans performed pretreatment and during weeks 2 and 4 of treatment and were evaluated for changes and association with response assessed on 3-month post-treatment FDG-PET/CT. Results: For all patients, the average pretreatment SUV{sub max} was 17.8, MTV was 55.4 cm{sup 3}, and FDG{sub hetero} was -1.33. A similar decline in SUV{sub max} was seen at week 2 compared with baseline and week 4 compared with week 2 (34%). The areas of highest FDG uptake in the tumor remained relatively consistent on serial scans. Mean FDG{sub hetero} decreased during treatment. For all patients, MTV decreased more from week 2 to week 4 than from pretreatment to week 2. By week 4, the average SUV{sub max} had decreased by 57% and the MTV had decreased by 30%. Five patients showed persistent or new disease on 3-month post-treatment PET. These poor responders showed a higher average SUV{sub max}, larger MTV, and greater heterogeneity at all 3 times. Week 4 SUV{sub max} (P=.037), week 4 FDG{sub hetero} (P=.005), pretreatment MTV (P=.008), and pretreatment FDG{sub hetero} (P=.008) were all significantly associated with post-treatment PET response. Conclusions: SUV{sub max} shows a consistent rate of decline during treatment and declines at a faster rate than MTV regresses. Based on this pilot study

  1. Medical Advocacy and Supportive Environments for African-Americans Following Abnormal Mammograms.

    Science.gov (United States)

    Molina, Yamile; Hempstead, Bridgette H; Thompson-Dodd, Jacci; Weatherby, Shauna Rae; Dunbar, Claire; Hohl, Sarah D; Malen, Rachel C; Ceballos, Rachel M

    2015-09-01

    African-American women experience disproportionately adverse outcomes relative to non-Latina White women after an abnormal mammogram result. Research has suggested medical advocacy and staff support may improve outcomes among this population. The purpose of the study was to understand reasons African-American women believe medical advocacy to be important and examine if and how staff can encourage and be supportive of medical advocacy. A convenience-based sample of 30-74-year-old women who self-identified as African-American/Black/of African descent and who had received an abnormal mammogram result was recruited from community-based organizations, mobile mammography services, and the local department of health. This qualitative study included semi-structured interviews. Patients perceived medical advocacy to be particularly important for African-Americans, given mistrust and discrimination present in medical settings and their own familiarity with their bodies and symptoms. Respondents emphasized that staff can encourage medical advocacy through offering information in general in a clear, informative, and empathic style. Cultural competency interventions that train staff how to foster medical advocacy may be a strategy to improve racial disparities following an abnormal mammogram.

  2. Histological changes caused by meclofenamic acid in androgen independent prostate cancer tumors: evaluation in a mouse model

    Directory of Open Access Journals (Sweden)

    Iván Delgado-Enciso

    2015-10-01

    Full Text Available ABSTRACT Meclofenamic acid is a nonsteroidal anti-inflammatory drug that has shown therapeutic potential for different types of cancers, including androgen-independent prostate neoplasms. The antitumor effect of diverse nonsteroidal anti-inflammatory drugs has been shown to be accompanied by histological and molecular changes that are responsible for this beneficial effect. The objective of the present work was to analyze the histological changes caused by meclofenamic acid in androgen-independent prostate cancer. Tumors were created in a nude mouse model using PC3 cancerous human cells. Meclofenamic acid (10 mg/kg/day; experimental group, n=5 or saline solution (control group, n=5 was administered intraperitoneally for twenty days. Histological analysis was then carried out on the tumors, describing changes in the cellular architecture, fibrosis, and quantification of cellular proliferation and tumor vasculature. Meclofenamic acid causes histological changes that indicate less tumor aggression (less hypercellularity, fewer atypical mitoses, and fewer nuclear polymorphisms, an increase in fibrosis, and reduced cellular proliferation and tumor vascularity. Further studies are needed to evaluate the molecular changes that cause the beneficial and therapeutic effects of meclofenamic acid in androgen-independent prostate cancer.

  3. [Cancer].

    Science.gov (United States)

    de la Peña-López, Roberto; Remolina-Bonilla, Yuly Andrea

    2016-09-01

    Cancer is a group of diseases which represents a significant public health problem in Mexico and worldwide. In Mexico neoplasms are the second leading cause of death. An increased morbidity and mortality are expected in the next decades. Several preventable risk factors for cancer development have been identified, the most relevant including tobacco use, which accounts for 30% of the cancer cases; and obesity, associated to another 30%. These factors, in turn, are related to sedentarism, alcohol abuse and imbalanced diets. Some agents are well knokn to cause cancer such as ionizing radiation, viruses such as the papilloma virus (HPV) and hepatitis virus (B and C), and more recently environmental pollution exposure and red meat consumption have been pointed out as carcinogens by the International Agency for Research in Cancer (IARC). The scientific evidence currently available is insufficient to consider milk either as a risk factor or protective factor against different types of cancer. PMID:27603890

  4. Chances and changes : psychological impact of genetic counselling and DNA testing for breast cancer.

    NARCIS (Netherlands)

    Dijk, Sandra van

    2006-01-01

    The cumulative lifetime risk of developing breast cancer for a Dutch woman is about 12%. In some families breast cancer seems to occur even more frequently or women fall ill at a relatively young age. Such families may have a genetic susceptibility towards breast cancer. To learn more about the like

  5. Five year change in alcohol intake and risk of breast cancer and coronary heart disease among postmenopausal women

    DEFF Research Database (Denmark)

    Dam, Marie K; Hvidtfeldt, Ulla A; Tjønneland, Anne;

    2016-01-01

    using Cox proportional hazards models. RESULTS: During the study, 1054, 1750, and 2080 cases of breast cancer, coronary heart disease, and mortality occurred, respectively. Analyses modelling five year change in alcohol intake with cubic splines showed that women who increased their alcohol intake over......OBJECTIVE: To test the hypothesis that postmenopausal women who increase their alcohol intake over a five year period have a higher risk of breast cancer and a lower risk of coronary heart disease compared with stable alcohol intake. DESIGN: Prospective cohort study. SETTING: Denmark, 1993...... disease, and all cause mortality during 11 years of follow-up. Information was obtained from the Danish Cancer Register, Danish Hospital Discharge Register, Danish Register of Causes of Death, and National Central Person Register. We estimated hazard ratios according to five year change in alcohol intake...

  6. [Reactive changes in psychological condition and behaviour in children of parents with cancer--results of an epidemiological survey].

    Science.gov (United States)

    Bergelt, Corinna; Ernst, Johanna Christine; Beierlein, Volker; Inhestern, Laura; Holes, Sarah; Möller, Birgit; Romer, Georg; Koch, Uwe

    2012-01-01

    Children of cancer patients are at risk for developing psychological symptoms. The parental appraisal of the child's psychological condition is a key variable for the utilization of child-centred psychosocial services. This study aimed at the systematic analysis of parental appraisals of changes in the emotional condition or behaviour of their children. We conducted an epidemiologic survey with a sample size of 1,809 patients with different cancer diagnoses, giving information about 2,581 children aged 21 years or younger at time of diagnosis. Quantitative information on children's distress during the disease and on changes in psychological condition or behaviour and qualitative information on the kind of changes were analysed. About half of the children were considered to be psychologically strongly affected during the disease. For about 25 % negative changes in psychological condition or behaviour are reported, positive changes are reported for 20 % of the children. Negative changes are most frequently described in young children (up to five years), positive changes are most frequently described in young adults (18 to 21 years). The results indicate that from the cancer parent's view many children are substantially distressed. Thus, the implementation of additional preventive psychosocial services seems reasonable and necessary. PMID:22950334

  7. 10-year epidemiological profile changes for cervical and endometrial cancer patients treated by radiotherapy in the Pernambuco state, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Cantinha, Rebeca S.; Santos, Mariana L.O.; Franca, Elvis J., E-mail: ejfranca@yahoo.com.br, E-mail: marianasantos_ufpe@hotmail.com, E-mail: rebecanuclear@gmail.com [Centro Regional de Ciencias Nucleares do Nordeste (CRCN-NE/CNEN-PE), Recife, PE (Brazil); Pessoa, Juanna G.; Melo, Ana M.M.A.; Amancio, Francisco F., E-mail: amdemelo@hotmail.com, E-mail: amanciobike@gmail.com, E-mail: juannapessoa@gmail.com, E-mail: marianasantos_ufpe@hotmail.com [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Departamento de Biofisica e Radiobiologia; Oliveira Neto, Aristides M.; Melo, Jonathan A., E-mail: aristidesoliveira466@hotmail.com, E-mail: jonathan@truenet.com.br [Centro de Radioterapia de Pernambuco (CERAPE), Santo Amaro, PE (Brazil)

    2014-07-01

    Cancer is a worldwide public health problem, its prevention and control are included within 16 strategic objectives of the Brazilian Ministry of Health for the period 2011-2015. Cervical cancer is the fourth most common tumor in the female population, being new 15,590 cases estimated for 2014 according to the Brazilian National Cancer Institute (INCA). Pernambuco is the fifth state with the highest number of cases of cervical cancer and the seventh in cases of endometrial ones, both estimative for 2014. The understanding of the epidemiological profile of these pathologies corroborates strategies for prevention, control and treatment. As Pernambuco has implemented the radiotherapy for cancer treatment since 1998-1999, this work encompassed the comparison of the 1998-1999 epidemiological profile of patients treated by radiotherapy for cervical and endometrial cancer in the State of Pernambuco, Brazil, with 2008-2009 profile - ten years after. Medical record of 490 patients treated at the Center of Radiotherapy of Pernambuco (CERAPE) were compiled according to the patient origin, the affected uterus region, the staging of disease, the type and cell differentiation of the tumor, the age group, and, finally, the realization of hysterectomy as part of the treatment. More than 90% of the patients were affected by cervical cancer in the two investigated periods. For the interval of 1998-1999 the proportion of patients submitted to hysterectomy was quite higher compared to those after ten years. The results also showed a change in the origin of the patients, in which, in 1999, most of the patients were from the capital and the metropolitan area, while, after ten years, patients were mostly from the interior of the State. There was a predominance of squamous cell type tumors in both periods evaluated. For the 1998-1999 interval, tumors were stage 2, moderately differentiated type. Differently, the tumors were mostly stage 3, not differentiated type, for the 2008-2009 period

  8. Changes in circulating microRNAs after radiochemotherapy in head and neck cancer patients

    International Nuclear Information System (INIS)

    Circulating microRNAs (miRNAs) are easily accessible and have already proven to be useful as prognostic markers in cancer patients. However, their origin and function in the circulation is still under discussion. In the present study we analyzed changes in the miRNAs in blood plasma of head and neck squamous cell carcinoma (HNSCC) patients in response to radiochemotherapy and compared them to the changes in a cell culture model of primary HNSCC cells undergoing simulated anti-cancer therapy. MiRNA-profiles were analyzed by qRT-PCR arrays in paired blood plasma samples of HNSCC patients before therapy and after two days of treatment. Candidate miRNAs were validated by single qRT-PCR assays. An in vitro radiochemotherapy model using primary HNSCC cell cultures was established to test the possible tumor origin of the circulating miRNAs. Microarray analysis was performed on primary HNSCC cell cultures followed by validation of deregulated miRNAs via qRT-PCR. Unsupervised clustering of the expression profiles using the six most regulated miRNAs (miR-425-5p, miR-21-5p, miR-106b-5p, miR-590-5p, miR-574-3p, miR-885-3p) significantly (p = 0.012) separated plasma samples collected prior to treatment from plasma samples collected after two days of radiochemotherapy. MiRNA profiling of primary HNSCC cell cultures treated in vitro with radiochemotherapy revealed differentially expressed miRNAs that were also observed to be therapy-responsive in blood plasma of the patients (miR-425-5p, miR-21-5p, miR-106b-5p, miR-93-5p) and are therefore likely to stem from the tumor. Of these candidate marker miRNAs we were able to validate by qRT-PCR a deregulation of eight plasma miRNAs as well as miR-425-5p and miR-93-5p in primary HNSCC cultures after radiochemotherapy. Changes in the abundance of circulating miRNAs during radiochemotherapy reflect the therapy response of primary HNSCC cells after an in vitro treatment. Therefore, the responsive miRNAs (miR-425-5p, miR-93-5p) may represent

  9. Changes in pulmonary function after incidental lung irradiation for breast cancer: A prospective study

    International Nuclear Information System (INIS)

    Purpose: The aim of this study was to analyze changes in pulmonary function after radiation therapy (RT) for breast cancer. Methods and Materials: A total of 39 consecutive eligible women, who underwent postoperative irradiation for breast cancer, were entered in the study. Spirometry consisting of forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1), carbon monoxide diffusing capacity (DLCO), and gammagraphic (ventilation and perfusion) pulmonary function tests (PFT) were performed before RT and 6, 12, and 36 months afterwards. Dose-volume and perfusion-weighted parameters were obtained from 3D dose planning: Percentage of lung volume receiving more than a threshold dose (Vi) and between 2 dose levels (V(i-j)). The impact of clinical and dosimetric parameters on PFT changes (ΔPFT) after RT was evaluated by Pearson correlation coefficients and stepwise lineal regression analysis. Results: No significant differences on mean PFT basal values (before RT) with respect to age, smoking, or previous chemotherapy (CT) were found. All the PFT decreased at 6 to 12 months. Furthermore FVC, FEV1, and ventilation recovered almost to their previous values, whereas DLCO and perfusion continued to decrease until 36 months (-3.3% and -6.6%, respectively). Perfusion-weighted and interval-scaled dose-volume parameters (pV(i-j)) showed better correlation with ΔPFT (only Δperfusion reached statistically significance at 36 months). Multivariate analysis showed a significant relation between pV(10-20) and Δperfusion at 3 years, with a multiple correlation coefficient of 0.48. There were no significant differences related to age, previous chemotherapy, concurrent tamoxifen and smoking, although a tendency toward more perfusion reduction in older and nonsmoker patients was seen. Conclusions: Changes in FVC, FEV1 and ventilation were reversible, but not the perfusion and DLCO. We have not found a conclusive mathematical predictive model, provided that the best model

  10. Proteomic changes resulting from gene copy number variations in cancer cells.

    Directory of Open Access Journals (Sweden)

    Tamar Geiger

    2010-09-01

    Full Text Available Along the transformation process, cells accumulate DNA aberrations, including mutations, translocations, amplifications, and deletions. Despite numerous studies, the overall effects of amplifications and deletions on the end point of gene expression--the level of proteins--is generally unknown. Here we use large-scale and high-resolution proteomics combined with gene copy number analysis to investigate in a global manner to what extent these genomic changes have a proteomic output and therefore the ability to affect cellular transformation. We accurately measure expression levels of 6,735 proteins and directly compare them to the gene copy number. We find that the average effect of these alterations on the protein expression is only a few percent. Nevertheless, by using a novel algorithm, we find the combined impact that many of these regional chromosomal aberrations have at the protein level. We show that proteins encoded by amplified oncogenes are often overexpressed, while adjacent amplified genes, which presumably do not promote growth and survival, are attenuated. Furthermore, regulation of biological processes and molecular complexes is independent of general copy number changes. By connecting the primary genome alteration to their proteomic consequences, this approach helps to interpret the data from large-scale cancer genomics efforts.

  11. Change in bone mineral density during adjuvant chemotherapy for early-stage breast cancer

    DEFF Research Database (Denmark)

    Christensen, Carina Ørts; Cronin-Fenton, Deirdre; Frøslev, Trine;

    2016-01-01

    PURPOSE: Adjuvant chemotherapy has been associated with loss of bone mineral density (BMD) either as a direct effect or due to glucocorticoids used as supportive care medication. A prospective cohort study was conducted to evaluate changes in BMD from baseline to right after completion of chemoth......PURPOSE: Adjuvant chemotherapy has been associated with loss of bone mineral density (BMD) either as a direct effect or due to glucocorticoids used as supportive care medication. A prospective cohort study was conducted to evaluate changes in BMD from baseline to right after completion...... of chemotherapy, i.e., 4 months. METHODS: Dual-imaging X-ray absorptiometry (DXA) was performed at baseline and after completing anthracycline- and taxane-based chemotherapy to measure BMD in the spine, hip, and forearm in early-stage breast cancer patients. High-dose prednisolone was used at three weekly...... were excluded: seven because of initiation of bisphosphonate treatment due to osteoporosis at baseline, and one had non-interpretable DXA. The final cohort included 97 patients with a mean age of 53 years (range 34-72). Mean cumulative prednisolone dose was 1308 mg (95 % CI 1255; 1362). BMD increased 1...

  12. Changes in serum and salivary amylase during radiotherapy for head and neck cancer

    International Nuclear Information System (INIS)

    The changes in serum amylase that occur when radiotherapy is given in the treatment of head and neck cancer has been studied in 41 patients, 29 treated by CHART and 12 by conventionally fractionated radiotherapy. The peak rise in serum amylase following the start of treatment is seen earlier and is greater in the patients receiving continuous hyperfractionated accelerated radiotherapy (CHART). The serum amylase returns to normal earlier in the CHART patients so that the area under the curve is the same for both groups. The difference probably reflects the more rapid delivery of treatment to the patients receiving CHART. A close correlation between the peak rise in serum amylase and the amount of parotid tissue in the treatment volume is demonstrated. For six patients the total amount of amylase secreted by the parotid gland during CHART was measured and found to decline rapidly within a few days of the start of radiotherapy. The rise in serum amylase that results from the irradiation of salivary tissue provides a unique biochemical measure of an early radiation effect in a normal tissue. This probably reflects the interphase cell death of serous salivary cells. Although these immediate changes are of considerable interest they may not relate to the late effects of radiation on salivary gland function. (author). 13 refs.; 4 figs

  13. Changes of Survivin mRNA and Protein Expression during Paclitaxel Treatment in Breast Cancer Cells

    Institute of Scientific and Technical Information of China (English)

    XIONG Huihua; YU Shiying; ZHUANG Liang; XIONG Hua

    2007-01-01

    In order to investigate the role of antiapoptosis gene, survivin in the resistance to palcitaxel, the expression of survivin mRNA and protein in the process of paclitaxel treatment in breast cancer cell line MCF-7 was detected. MCF-7 cells were incubated with paclitaxel at different concentrations. The growth inhibition rate of MCF-7 was investigated by tetrazolium bromide (MTT) colorimetry. The change of apoptosis was detected by Annexin-V/PI methods. The changes in the expression of survivin mRNA and protein were studied by reverse transcription polymerase chain reaction (RT-PCR) and Western-blot assay respectively. The growth inhibition rate of MCF-7 was increased in a concentration- and time-dependent manner. Paclitaxel of higher concentration could effectively induce apoptosis in MCF-7 cells after 48 h, while the expression of survivin was increased at early time (within 6 h) and decreased after 24 h regardless of treatment concentrations of paclitaxel. It suggested that tumor cells might evade the paclitaxel-induced cell cycle arrest and apoptosis by increasing the level of survivin at early treatment time.

  14. Changes in acute response to radiation after implementation of new national guidelines for head and neck cancer

    DEFF Research Database (Denmark)

    Hansen, C. R.; Bertelsen, Anders; Zukauskaite, R.;

    2015-01-01

    Purpose/Objective: New national guidelines (GL) for radiotherapy (RT) of head and neck cancer (HNC) were implemented at the beginning of 2013. One purpose of the new GL was to nationally standardise the expansion from GTV to high risk CTV (CTV1). This standardisation has resulted in change...

  15. Changes in Quality of Life and Anxiety of Lung Cancer Patients Underwent 
Chemotherapy

    Directory of Open Access Journals (Sweden)

    Shufang LI

    2012-08-01

    Full Text Available Background and objective This study aims to observe the changes in quality of life as well as the anxiety among lung cancer patients before and after chemotherapy. This work also aims to explore the effect of chemotherapy on quality of life and anxiety. Methods Fifty-eight lung cancer patients were evaluated based on clinical outcomes, EORTC QLQ-C30, and on SAS questionnaires before chemotherapy, one week after two courses of chemotherapy, and one week after four courses of chemotherapy. Results Before chemotherapy, functioning scale, fatigue, and dyspnoea scores were high, the rate of anxiety was 56%, while the SAS score was 49.54±5.64. Anxiety was found to be positively correlated with insomnia (P<0.05. After two courses of chemotherapy, dyspnoea scores decreased, while insomnia and appetite loss scores increased. The difference was statistically significant (P<0.05. The rate of anxiety was 80%, and the SAS score was 52.48±6.10. The difference was statistically significant compared with that before chemotherapy (P<0.05. The SAS scores of patients with disease history were higher than those of patients without disease history (P<0.05. SAS score was found to be positively correlated with fatigue and dyspnoea (P<0.05. After four courses of chemotherapy, the physical, role, emotional, and social function scores decreased, while the nausea and vomiting, appetite loss, constipation, and financial impact scores increased. The difference was statistically significant (P<0.05. The anxiety rate was 72%, and the SAS score was 54.82±6.55. The difference was statistically significant (P<0.05. The SAS score was negatively correlated with KPS (P<0.05, significantly positively correlated with fatigue and insomnia (P<0.01, and positively correlated with constipation (P<0.05. Conclusion A number of patients have experienced symptom relief, but during chemotherapy, the patients had significant anxiety. Thus, quality of life decreased. The quality of life and

  16. The changing landscape of brachytherapy for cervical cancer: a Canadian practice survey

    Science.gov (United States)

    Phan, T.; Mula-Hussain, L.; Pavamani, S.; Pearce, A.; D’Souza, D.; Patil, N.G.; Traptow, L.; Doll, C.M.

    2015-01-01

    Background We documented changes in practice from 2009 to 2012 for cervical cancer brachytherapy in Canada. Methods Centres with gynecologic brachytherapy services were sent an e-mail questionnaire querying their 2012 practice. Responses are reported and compared with practice patterns identified in a similar survey for 2009. Results The response rate was 77% (24 of 31 centres). Almost all use high-dose-rate brachytherapy (92%); low-dose-rate brachytherapy has been completely phased out. Most continue to move patients from the site of applicator insertion to the radiation treatment simulation suite (75%) or to a diagnostic imaging department (29%), or both. In 2012, the imaging modalities used for dose specification were computed tomography [ct (75%)], magnetic resonance imaging [mri (38%)], plain radiography (21%), and cone-beam ct (8%). The number of institutions using mri guidance has markedly increased during the period of interest (9 vs. 1). Most respondents (58% vs. 14%) prescribed using guidelines from the Groupe Européen de Curiethérapie and the European Society for Therapeutic Radiology and Oncology, but they also used point A as a reference. Commonly used high-dose radiation regimens included 30 Gy in 5 fractions and 24 Gy in 3 fractions. Conclusions In Canada, image-guided brachytherapy for cervical cancer continues to evolve. Although ct-based imaging remains the most commonly used modality, many centres have adopted mri for at least 1 brachytherapy treatment. More centres are using fewer fractions and a slightly lower biologically effective dose, but are still achieving EQD2 (2-Gy equivalent) doses of 80–90 Gy in combination with external-beam radiation therapy. PMID:26628868

  17. Changes in Bone Mineral Density in Uterine Cervical Cancer Patients After Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Okonogi, Noriyuki; Saitoh, Jun-ichi; Suzuki, Yoshiyuki, E-mail: syoshi@gunma-u.ac.jp; Noda, Shin-ei; Ohno, Tatsuya; Oike, Takahiro; Ohkubo, Yu; Ando, Ken; Sato, Hiro; Nakano, Takashi

    2013-12-01

    Purpose: To prospectively investigate the changes in bone mineral density (BMD) after pelvic radiation therapy in patients with uterine cervical cancer. Methods and Materials: Of 52 cervical cancer patients who received pelvic RT in our university hospital between 2009 and 2011, 46 patients without recurrence and who were followed up for more than 12 months were included in the study. The BMD of the irradiated region and nonirradiated regions, serum estradiol, tartrate-resistant acid phosphatase-5b, and N-terminal cross-linking telopeptide of collagen 1 were measured before, at 3 months after, and at 12 months after RT. The patient cohort was divided into 2 groups according to estradiol level before RT, and the groups were defined as postmenopausal (<40 pg/mL) and premenopausal (≥40 pg/mL). Results: The mean BMDs within the irradiation field (lumbar vertebra 5) in the postmenopausal and the premenopausal groups were 0.825 and 0.910 g/cm{sup 2} before RT and 0.746 and 0.841 g/cm{sup 2} 12 months after RT, respectively. Significant decreases were observed in both groups (P<.05 and P<.01, respectively). In addition, in the premenopausal group the mean BMDs of the nonirradiated regions at thoracic vertebrae 9-12 and lumbar vertebrae 2-4 were 0.753 and 0.958 g/cm{sup 2} before RT and were significantly decreased to 0.706 and 0.921 g/cm{sup 2} 12 months after RT (P<.01 and P<.05, respectively). Estradiol significantly decreased 3 months after RT, whereas tartrate-resistant acid phosphatase-5b and N-terminal cross-linking telopeptide of collagen 1 continued to increase over time in the premenopausal group. Conclusions: A decrease in BMD in the irradiated region after RT was observed within 1 year, regardless of menopausal status. Furthermore, in premenopausal patients, pelvic RT caused a decrease in systemic BMD.

  18. The effect of changes in dosimetry on cancer mortality risk estimates in the atomic bomb survivors

    International Nuclear Information System (INIS)

    In the spring of 1986, RERF received a new dosimetry system which was developed by the US-Japan Committee for Reassessment of Atomic Bomb Radiation Dosimetry in Hiroshima and Nagasaki. This report presents the comparisons of leukemia and nonleukemia cancer mortality risk estimates under the old and new dosimetries. In terms of total kerma (essentially whole-body gamma-ray plus neutron exposure), the risk estimates for both types of cancer are 75 %-85 % higher with the new dosimetry. This and other summary comparisons here make some allowance for possible nonlinearity at high estimated doses. It is also important to consider the changes in relation to organ doses and assumptions about the relative biological effectiveness (RBE) of neutrons. Without regard to RBE, the risk estimates for total organ dose are essentially unchanged by the dosimetry revision. However, with increasing assumed values of RBE, the estimated low-LET risk decreases much less rapidly under the new dosimetry, due to the smaller neutron component. Thus at an assumed constant RBE of 10, for example, the effect of the dosimetry revision is to increase organ dose risk estimates, relative to those based on the old dosimetry, by 30 % for nonleukemia and 80 % for leukemia. At an RBE of 20 these increases are 72 % and 136 %, respectively. A number of other issues are discussed. The city difference in dose-response is smaller with the new dosimetry, and is no longer statistically significant, even at an RBE of one. Estimation of RBE is even less feasible with the new dosimetry. There is substantial question of the linearity in dose-response, in the sense of a leveling off at higher doses. Finally, some indication is given of how estimated lifetime risks from this dosimetry may compare to widely-used estimates based largely on the RERF data with the previous dosimetry. (author)

  19. Validity, reliability and responsiveness to change of the Italian palliative care outcome scale:A multicenter study of advanced cancer patients Cancer palliative care

    OpenAIRE

    COSTANTINI, MASSIMO; Rabitti, Elisa; Beccaro, Monica; Fusco, Flavio; Peruselli, Carlo; La Ciura, Pietro; Valle, Alessandro; Suriani, Cinzia; Berardi, Maria Alejandra; Valenti, Danila; Mosso, Felicita; Morino, Piero; Zaninetta, Giovanni; Tubere, Giorgio; Piazza, Massimo

    2016-01-01

    Background There is an increasing requirement to assess outcomes, but few measures have been tested for advanced medical illness. We aimed to test the validity, reliability and responsiveness of the Palliative care Outcome Scale (POS), and to analyse predictors of change after the transition to palliative care. Methods Phase 1: multicentre, mixed method study comprising cognitive and qualitative interviews with patients and staff, cultural refinement and adaption. Phase 2: consecutive cancer ...

  20. Healthy pigs for healthy people. A cysticercosis advocacy information tool

    DEFF Research Database (Denmark)

    Saarnak, Christopher; Johansen, Maria Vang; Mejer, Helena;

    2013-01-01

    Saarnak, C., M. V. Johansen, H. Mejer, C. Trevisan, and U. C. Braae Porcine cysticercosis is an infection of pigs caused by the larval stage of Taenia solium, a tapeworm that causes taeniosis in humans. The disease is common in developing countries and is a serious public health risk. Cysticercos...... to the laymen in the villages, information for supporting practitioners; MD’s in health centres, veterinary and agricultural extension officers and pig traders. Furthermore there will be a policy brief aimed at the key decision makers at ministry level........ Consequently, the intervention strategies to prevent and control cysticercosis must be on health education engaging the communities and creating public awareness. Enhancing basic conditions such as hygiene has an important effect on reducing the risk of transmission. In addition some very simple but effective...... but also other endemic zoonotic diseases. ICONZ and ADVANZ are two One Health neglected zoonotic diseases projects, funded by the European Commission through its 7th framework program. Part of University of Copenhagen’s tasks in these projects is to develop an improved advocacy tool for teaching about...

  1. From Advocacy to Action in Global Adolescent Health.

    Science.gov (United States)

    Patton, George C; Sawyer, Susan M; Ross, David A; Viner, Russell M; Santelli, John S

    2016-10-01

    In May 2016, The Lancet published a report titled, "Our Future: A Lancet Commission on Adolescent Health and Wellbeing," the culmination of three years of work from a geographically diverse interdisciplinary group. The report argued that healthy growth across adolescence and young adulthood shapes life course and intergenerational trajectories so that health investments yield a "triple dividend." With current global interest in adolescent health at an unprecedented level, it outlines three next steps to advance from advocacy to effective action: (1) there is a pressing need for comprehensive and integrated strategies, inclusive of, but extending beyond, sexual and reproductive health, and HIV; (2) interventions should address both adolescent health service coverage and determinants of health that lie in sectors such as education, justice, transport, and industry and employment, as well as families and local communities; and (3) scale-up of responses will require not only investments in country-level capacities for measuring need and responding with evidence-based practice but also the establishment of processes for accountability and meaningful youth engagement.

  2. Mortality of breast cancer in Taiwan, 1971–2010: Temporal changes and an age–period–cohort analysis

    Science.gov (United States)

    Ho, M.-L.; Hsiao, Y.-H.; Su, S.-Y.

    2015-01-01

    The current paper describes the age, period and cohort effects on breast cancer mortality in Taiwan. Female breast cancer mortality data were collected from the Taiwan death registries for 1971–2010. The annual percentage changes, age- standardised mortality rates (ASMR) and age–period–cohort model were calculated. The mortality rates increased with advancing age groups when fixing the period. The percentage change in the breast cancer mortality rate increased from 54.79% at aged 20–44 years, to 149.78% in those aged 45–64 years (between 1971–75 and 2006–10). The mortality rates in the 45–64 age group increased steadily from 1971 to 1975 and 2006–10. The 1951 birth cohorts (actual birth cohort; 1947–55) showed peak mortalities in both the 50–54 and 45–49 age groups. We found that the 1951 birth cohorts had the greatest mortality risk from breast cancer. This might be attributed to the DDT that was used in large amounts to prevent deaths from malaria in Taiwan. However, future researches require DDT data to evaluate the association between breast cancer and DDT use. PMID:25020211

  3. Mortality of breast cancer in Taiwan, 1971-2010: temporal changes and an age-period-cohort analysis.

    Science.gov (United States)

    Ho, M-L; Hsiao, Y-H; Su, S-Y; Chou, M-C; Liaw, Y-P

    2015-01-01

    The current paper describes the age, period and cohort effects on breast cancer mortality in Taiwan. Female breast cancer mortality data were collected from the Taiwan death registries for 1971-2010. The annual percentage changes, age- standardised mortality rates (ASMR) and age-period-cohort model were calculated. The mortality rates increased with advancing age groups when fixing the period. The percentage change in the breast cancer mortality rate increased from 54.79% at aged 20-44 years, to 149.78% in those aged 45-64 years (between 1971-75 and 2006-10). The mortality rates in the 45-64 age group increased steadily from 1971 to 1975 and 2006-10. The 1951 birth cohorts (actual birth cohort; 1947-55) showed peak mortalities in both the 50-54 and 45-49 age groups. We found that the 1951 birth cohorts had the greatest mortality risk from breast cancer. This might be attributed to the DDT that was used in large amounts to prevent deaths from malaria in Taiwan. However, future researches require DDT data to evaluate the association between breast cancer and DDT use.

  4. How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models

    NARCIS (Netherlands)

    van Gisbergen, M. W.; Voets, A. M.; Starmans, M. H. W.; de Coo, I. F. M.; Yadak, R.; Hoffmann, R. F.; Boutros, P. C.; Smeets, H. J. M.; Dubois, L.; Lambin, P.

    2015-01-01

    Several mutations in nuclear genes encoding for mitochondrial components have been associated with an increased cancer risk or are even causative, e.g. succinate dehydrogenase (SDHB, SDHC and SDHD genes) and iso-citrate dehydrogenase (IDH1 and IDH2 genes). Recently, studies have suggested an eminent

  5. Building a Generation of Physician Advocates: The Case for Including Mandatory Training in Advocacy in Canadian Medical School Curricula.

    Science.gov (United States)

    Bhate, Tahara D; Loh, Lawrence C

    2015-12-01

    There is an increasing focus on the social accountability of physicians as individuals, and of medicine itself. This has led to increasing emphasis on physician advocacy from a wide variety of institutions. The physician advocacy concept is now part of the Health Advocacy competency mandated by the Royal College of Physicians and Surgeons of Canada. Despite its growing prominence, physician advocacy remains poorly integrated into current medical undergraduate curricula. The authors recommend how and why curricular reform should proceed; they focus on Canadian medical education, although they hope their views will be useful in other countries as well.The authors discuss conflicting definitions of physician advocacy, which have previously hampered curriculum development efforts, and suggest a way of reconciling the conflicts. They review current gaps in advocacy-related curricula, suggest that these can be addressed by incorporating practice-based and skills acquisition elements into current didactic teaching, and offer several strategies by which an advocacy curriculum could be implemented, ranging from small modifications to current curriculum to developing new competencies in medical education nationally.The authors present a case for making an advocacy curriculum mandatory for every Canadian medical trainee; they argue that teaching trainees how to fulfill their professional responsibility to advocate may also help them meet the social accountability mandate of medical school education. Finally, the authors explain why making the development and implementation of a mandatory, skill-based curriculum in advocacy should be a priority.

  6. \\Defining Patient Advocacy for the Context of Clinical Ethics Consultation: A Review of the Literature and Recommendations for Consultants.

    Science.gov (United States)

    Brazg, Tracy; Lindhorst, Taryn; Dudzinski, Denise; Wilfond, Benjamin

    2016-01-01

    The idea of patient advocacy as a function of clinical ethics consultation (CEC) has been debated in the bioethics literature. In particular, opinion is divided as to whether patient advocacy inherently is in conflict with the other duties of the ethics consultant, especially that of impartial mediator. The debate is complicated, however, because patient advocacy is not uniformly conceptualized. This article examines two literatures that are crucial to understanding patient advocacy in the context of bioethical deliberations: the CEC literature and the literature on advocacy in the social work profession. A review of this literature identifies four distinct approaches to patient advocacy that are relevant to CEC: (1) the best interest approach, (2) the patient rights approach, (3) the representational approach, and (4) the empowerment approach. After providing a clearer understanding of the varied meanings of patient advocacy in the context of CEC, we assert that patient advocacy is not inherently inconsistent with the function of the ethics consultant and the CEC process. Finally, we provide a framework to help consultants determine if they should adopt an advocacy role.

  7. Building a Generation of Physician Advocates: The Case for Including Mandatory Training in Advocacy in Canadian Medical School Curricula.

    Science.gov (United States)

    Bhate, Tahara D; Loh, Lawrence C

    2015-12-01

    There is an increasing focus on the social accountability of physicians as individuals, and of medicine itself. This has led to increasing emphasis on physician advocacy from a wide variety of institutions. The physician advocacy concept is now part of the Health Advocacy competency mandated by the Royal College of Physicians and Surgeons of Canada. Despite its growing prominence, physician advocacy remains poorly integrated into current medical undergraduate curricula. The authors recommend how and why curricular reform should proceed; they focus on Canadian medical education, although they hope their views will be useful in other countries as well.The authors discuss conflicting definitions of physician advocacy, which have previously hampered curriculum development efforts, and suggest a way of reconciling the conflicts. They review current gaps in advocacy-related curricula, suggest that these can be addressed by incorporating practice-based and skills acquisition elements into current didactic teaching, and offer several strategies by which an advocacy curriculum could be implemented, ranging from small modifications to current curriculum to developing new competencies in medical education nationally.The authors present a case for making an advocacy curriculum mandatory for every Canadian medical trainee; they argue that teaching trainees how to fulfill their professional responsibility to advocate may also help them meet the social accountability mandate of medical school education. Finally, the authors explain why making the development and implementation of a mandatory, skill-based curriculum in advocacy should be a priority. PMID:26200573

  8. Highlights from the Ninth European Breast Cancer Conference, Glasgow, 19–21 March 2014

    OpenAIRE

    Munzone, Elisabetta

    2014-01-01

    The Ninth European Breast Cancer Conference (EBCC-9), one of the largest breast cancer conferences in the world, was held in Glasgow in March 2014, and brought together the voices of doctors, researchers, nurses, and patients. All the major breast cancer advocacy groups and institutions were united in one forum (Europa Donna, the EORTC Breast Cancer group, and EUSOMA). The Scientific Programme for EBCC-9 highlighted a holistic picture of breast cancer, including research, prevention, treatmen...

  9. Community-based advocacy training: applying asset-based community development in resident education.

    Science.gov (United States)

    Hufford, Laura; West, Daniel C; Paterniti, Debora A; Pan, Richard J

    2009-06-01

    Communities and Physicians Together (CPT) at University of California, Davis Health System provides a novel approach to teaching residents to be effective community advocates. Founded in 1999, CPT is a partnership between a pediatric residency program, five community collaboratives located in diverse neighborhoods, and a grassroots child advocacy organization. Using the principles of Asset-Based Community Development, the program emphasizes establishing partnerships with community members and organizations to improve child health and identifies community assets and building capacity. Community members function as the primary faculty for CPT.The authors describe the CPT curriculum, which teaches residents to build partnerships with their assigned community. Residents have three, two-week blocks each year for CPT activities and maintain a longitudinal relationship with their community. In the first year, collaborative coordinators from each community orient residents to their community. Residents identify community assets and perform activities designed to provide them with a community member's perspective. In the second and third years, residents partner with community members and organizations to implement a project to improve the health of children in that community. CPT also provides faculty development to community partners including a workshop on medical culture and resident life. A qualitative evaluation demonstrated residents' attitudes of their role as pediatricians in the community changed with CPT.CPT is unique because it provides a model of service learning that emphasizes identifying and utilizing strengths and building capacity. This approach differs from the traditional medical model, which emphasizes deficits and needs. PMID:19474556

  10. Adaptive radiotherapy for soft tissue changes during helical tomotherapy for head and neck cancer

    Energy Technology Data Exchange (ETDEWEB)

    Duma, M.N.; Kampfer, S.; Winkler, C.; Geinitz, H. [Universitaetsklinikum rechts der Isar, Muenchen (Germany). Dept. of Radiation Oncology; Schuster, T. [Universitaetsklinikum rechts der Isar, Muenchen (Germany). Inst. of Medical Statistics and Epidemiology

    2012-03-15

    The goal of the present study was to assess the frequency and impact of replanning triggered solely by soft tissue changes observed on the daily setup mega-voltage CT (MVCT) in head and neck cancer (H and N) helical tomotherapy (HT). A total of 11 patients underwent adaptive radiotherapy (ART) using MVCT. Preconditions were a soft tissue change > 0.5 cm and a tight mask. The dose-volume histograms (DVHs) derived from the initial planning kVCT (inPlan), the recalculated DVHs of the fraction (fx) when replanning was decided (actSit) and the DVHs of the new plan (adaptPlan) were compared. Assessed were the following: maximum dose (D{sub max}), minimum dose (D{sub min}), and mean dose (D{sub mean}) to the planning target volume (PTV) normalized to the prescribed dose; the D{sub mean}/fx to the parotid glands (PG), oral cavity (OC), and larynx (Lx); and the D{sub max}/fx to the spinal cord (SC) in Gy/fx. No patient had palpable soft tissue changes. The median weight loss at the moment of replanning was 2.3 kg. The median PTV D{sub mean} was 100% for inPlan, 103% for actSit, and 100% for adaptPlan. The PTV was always covered by the prescribed dose. A statistically significant increase was noted for all organs at risk (OAR) in the actSit. The D{sub mean} to the Lx, the D{sub mean} to the OC and the D{sub max} to the SC were statistically better in the adaptPlan. No statistically significant improvement was achieved by ART for the PGs. No significant correlations between weight and volume loss or between the volume changes of the organs to each other were observed, except a strong positive correlation of the shrinkage of the PGs ({rho} = + 0.77, p = 0.005). Soft tissue shrinkage without clinical palpable changes will not affect the coverage of the PTV, but translates into a higher delivered dose to the PTV itself and the normal tissue outside the PTV. The gain by ART in individual patients - especially in patients who receive doses close to the tolerance doses of the OAR

  11. Reflections on the New Classification of Tumors by the WHO and Changes in Esophageal Cancer in a High-risk Area

    Institute of Scientific and Technical Information of China (English)

    Zhifeng Chen

    2006-01-01

    In year 2000, a book entitled the Pathology and Genetics of Tumors of the Digestive System was published by the WHO, presenting some new diagnostic criteria and treatment principles. I have analyzed the epidemiologic change of tumors in over 30 years in the high-risk area with esophageal cancer. The following phenomenon was found: accompanied by the sharp decrease in the incidence and mortality of esophageal cancer, there was an increase in the incidence and death rate of stomach cancer involving cardiac cancer. This fact should be considered when analyzing the sharp decrease in esophageal cancer incidence and mortality rate. More attention was given to diagnosis of cardiac cancer; at the same time it is more practical to improve the early screening of cancers. To observe the development of high and lowgrade intraepithelial neoplasms will be an urgent task for esophageal cancer research in the high risk area, according to WHO's new classification.

  12. Pathogen-driven gastrointestinal cancers: Time for a change in treatment paradigm?

    Directory of Open Access Journals (Sweden)

    Aituov Bauyrzhan

    2012-08-01

    Full Text Available Abstract The regulation of cancerous tumor development is converged upon by multiple pathways and factors. Besides environmental factors, gastrointestinal (GI tract cancer can be caused by chronic inflammation, which is generally induced by bacteria, viruses, and parasites. The role of these inducers in cancer development, cell differentiation and transformation, cell cycle deregulation, and in the expression of tumor-associated genes cannot be ignored. Although Helicobacter pylori activates many oncogenic pathways, particularly those in gastric and colorectal cancers, the role of viruses in tumor development is also significant. Viruses possess significant oncogenic potential to interfere with normal cell cycle control and genome stability, stimulating the growth of deregulated cells. An increasing amount of recent data also implies the association of GI cancers with bacterial colonization and viruses. This review focuses on host-cell interactions that facilitate primary mechanisms of tumorigenesis and provides new insights into novel GI cancer treatments.

  13. Lung cancer in never smokers: change of a mindset in the molecular era.

    Science.gov (United States)

    Lee, Young Joo; Kim, Joo-Hang; Kim, Se Kyu; Ha, Sang-Jun; Mok, Tony S; Mitsudomi, Tetsuya; Cho, Byoung Chul

    2011-04-01

    Lung cancer is a leading cause of cancer-related mortality across the world. Although the majority of lung cancer is attributed to tobacco smoke, approximately 25% of lung cancers worldwide occur in lifelong never smokers. Over the past decades, the bulk of research on this disease suggested that several genetic, environmental, hormonal, and viral factors might increase the risk of lung cancer among never smokers. However, there has been no dominant risk factor whose significance has been validated across racial and ethnic groups. However, this subset of lung cancers has received renewed attention due to the introduction of the epidermal growth factor receptor-tyrosine kinase (EGFR-TK) inhibitors showing the dramatic therapeutic response on selected patients with activating EGFR mutations which occur more commonly in never smokers. The treatment strategy blocking EGFR pathway in EGFR-mutant lung cancer represents a remarkable example of molecular targeted therapies which completely repress tumor by inhibition of driving oncogenes. More recently, a surprising positive effect of an ALK inhibitor on EML4-ALK-positive lung cancer has been suggested that lung cancer in never smokers is likely to be an assemblage of molecularly defined subsets which would be a good candidate for personalized diagnostic and therapeutic approaches. PMID:21272954

  14. Power and Politics in the Global Health Landscape: Beliefs, Competition and Negotiation Among Global Advocacy Coalitions in the Policy-Making Process

    Directory of Open Access Journals (Sweden)

    Lori McDougall

    2016-05-01

    Full Text Available Background Advocacy coalitions play an increasingly prominent role within the global health landscape, linking actors and institutions to attract political attention and resources. This paper examines how coalitions negotiate among themselves and exercise hidden forms of power to produce policy on the basis of their beliefs and strategic interests. Methods This paper examines the beliefs and behaviours of health advocacy coalitions using Sabatier’s Advocacy Coalition Framework (ACF as an informal theoretical lens. Coalitions are further explored in relation to the concept of transnational advocacy networks (Keck and Sikkink and of productive power (Shiffman. The ACF focuses on explaining how policy change takes place when there is conflict concerning goals and technical approaches among different actors. This study uses participant observation methods, self-reported survey results and semistructured qualitative interviews to trace how a major policy project of the Millennium Development Goal (MDG era, the Global Strategy for Women’s and Children’s Health, was constructed through negotiations among maternal, newborn, and child health (MNCH and sexual and reproductive health and rights (SRHR advocacy coalitions. Results The Global Strategy represented a new opportunity for high-level political attention. Despite differing policy beliefs, MNCH and SRHR actors collaborated to produce this strategy because of anticipated gains in political attention. While core beliefs did not shift fundamentally and collaboration was primarily a short-term tactical response to a time-bound opportunity, MNCH actors began to focus more on human rights perspectives and SRHR actors adopted greater use of quantifiable indicators and economic argumentation. This shift emphasises the inherent importance of SRHR to maternal and child health survival. Conclusion As opportunities arise, coalitions respond based on principles and policy beliefs, as well as to perceptions

  15. Health advocacy training: why are physicians withholding life-saving care?

    Science.gov (United States)

    Gill, Peter J; Gill, Harbir S

    2011-01-01

    The societal responsibility of physicians to be health advocates, both at the population and patient level is necessary to positively influence public health and policy. Physicians must commit to learn about policy reform and the legislative process. Several regulatory physician organizations emphasize the importance of health. In addition, the Association of American Medical Colleges' (AAMC) Medical Schools Objectives Project, the Medical Council of Canada Qualifying Examination objectives and several Canadian medical schools outline advocacy as an objective. As a result, several US medical schools have designed and incorporated health advocacy into their curricula. Canadian medical schools, however, have been lagging behind. To address this deficiency, the University of Alberta and the University of Calgary hosted the 1st Annual Alberta Political Action Day (PAD) to engage medical students in advocacy and the policy making process. The two-day time requirement of PAD makes it an efficient model to incorporate health advocacy into the already demanding undergraduate medical curriculum. Canadian medical schools must follow the American example and further integrate initiatives such as PAD to teach health advocacy. The skills developed will enhance student's comprehension of how they can shape health policy and truly advocate for optimal patient care. PMID:21070115

  16. Change in HER-2/neu Status from Negative to Positive following Treatment in Breast Cancer: A Case Report

    Directory of Open Access Journals (Sweden)

    Lakshmi Sivarajan

    2011-01-01

    Full Text Available Introduction: Approximately 25–30% of breast cancers are assumed to be HER-2/neu positive. It is well known that HER-2/neu-positive cancers after treatment with trastuzumab can become HER-2/neu negative. Change in HER-2/neu status from negative to positive following treatment has not been well studied. We describe a patient with inflammatory breast cancer who was initially HER-2/neu negative but became positive after treatment. A 59-year-old postmenopausal white female saw her surgeon for violaceous discoloration of the left breast for 4 months. The surgeon palpated a mass measuring 6 cm in the patient’s left breast. Additionally, there was violaceous discoloration involving two thirds of the breast. Biopsy of the breast mass and skin revealed inflammatory breast cancer. The tumor was estrogen receptor positive, progesterone receptor positive and HER-2/neu negative. The patient was given four cycles of chemotherapy with cyclophosphamide, doxorubicin and docetaxol. She subsequently underwent a mastectomy, excision of the skin over the chest wall and axillary node dissection. Of the axillary lymph nodes, 14/14 were involved. The tumor was still estrogen receptor positive and progesterone receptor positive, but HER-2/neu was 2+ by immunohistochemistry and amplified at 3.3 as detected by fluorescent in situhybridization. The patient received trastuzumab along with chemotherapy followed by radiation therapy and letrozole. She is currently receiving trastuzumab and letrozole in the adjuvant setting and appears to be doing well. Conclusion: A breast cancer which was initially HER-2/neu negative can become positive following treatment. Therefore, re-biopsy may be necessary during the course of treatment of breast cancer to re-assess the HER-2/neu status. This gives the clinician the opportunity to include drugs like trastuzumab and lapatinib in the treatment of patients with a transformation to HER-2/neu-positive cancer.

  17. Coffee Polyphenols Change the Expression of STAT5B and ATF-2 Modifying Cyclin D1 Levels in Cancer Cells

    Directory of Open Access Journals (Sweden)

    Carlota Oleaga

    2012-01-01

    Full Text Available Background. Epidemiological studies suggest that coffee consumption reduces the risk of cancer, but the molecular mechanisms of its chemopreventive effects remain unknown. Objective. To identify differentially expressed genes upon incubation of HT29 colon cancer cells with instant caffeinated coffee (ICC or caffeic acid (CA using whole-genome microarrays. Results. ICC incubation of HT29 cells caused the overexpression of 57 genes and the underexpression of 161, while CA incubation induced the overexpression of 12 genes and the underexpression of 32. Using Venn-Diagrams, we built a list of five overexpressed genes and twelve underexpressed genes in common between the two experimental conditions. This list was used to generate a biological association network in which STAT5B and ATF-2 appeared as highly interconnected nodes. STAT5B overexpression was confirmed at the mRNA and protein levels. For ATF-2, the changes in mRNA levels were confirmed for both ICC and CA, whereas the decrease in protein levels was only observed in CA-treated cells. The levels of cyclin D1, a target gene for both STAT5B and ATF-2, were downregulated by CA in colon cancer cells and by ICC and CA in breast cancer cells. Conclusions. Coffee polyphenols are able to affect cyclin D1 expression in cancer cells through the modulation of STAT5B and ATF-2.

  18. Association between Changing Mortality of Digestive Tract Cancers and Water Pollution: A Case Study in the Huai River Basin, China

    Directory of Open Access Journals (Sweden)

    Hongyan Ren

    2014-12-01

    Full Text Available The relationship between the ever-increasing cancer mortality and water pollution is an important public concern in China. This study aimed to explore the association between serious water pollution and increasing digestive cancer mortality in the Huai River Basin (HRB in China. A series of frequency of serious pollution (FSP indices including water quality grade (FSPWQG, biochemical oxygen demand (FSPBOD, chemical oxygen demand (FSPCOD, and ammonia nitrogen (FSPAN were used to characterize the surface water quality between 1997 and 2006. Data on the county-level changing mortality (CM due to digestive tract cancers between 1975 and 2006 were collected for 14 counties in the study area. Most of investigated counties (eight with high FSPWQG (>50% distributed in the northern region of the HRB and had larger CMs of digestive tract cancers. In addition to their similar spatial distribution, significant correlations between FSP indices and CMs were observed by controlling for drinking water safety (DWS, gross domestic product (GDP, and population (POP. Furthermore, the above-mentioned partial correlations were clearly increased when only controlling for GDP and POP. Our study indicated that county-level variations of digestive cancer mortality are remarkably associated with water pollution, and suggested that continuous measures for improving surface water quality and DWS and hygienic interventions should be effectively implemented by local governments.

  19. Changes in soluble CEA and TIMP-1 levels during adjuvant chemotherapy for stage III colon cancer

    DEFF Research Database (Denmark)

    Aldulaymi, Bahir; Christensen, Ib J; Sölétormos, György;

    2010-01-01

    Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been suggested to be a valuable marker in colorectal cancer (CRC), but the effects of chemotherapy on TIMP-1 levels are unknown. The present study evaluated the effect of chemotherapy on TIMP-1 levels in comparison with carcinoembryonic antigen...... (CEA) levels in patients with stage III colon cancer....

  20. Changes in body weight during various types of chemotherapy in breast cancer patients

    NARCIS (Netherlands)

    Winkels, R.M.; Beijer, S.; Lieshout, van R.; Barneveld, van D.; Hofstede, ter J.; Kampman, E.

    2014-01-01

    Background & aims Weight gain is a common problem for breast cancer patients treated with chemotherapy. It increases the risk of several comorbidities and possibly cancer recurrence. We assessed whether weight gain depends on the type of chemotherapy. Methods In a retrospective study among 739 b