Sample records for canal beagle tierra

  1. Heavy metal concentrations in litteral sediments from the Beagle Channel, Tierra del Fuego, Argentina. (United States)

    Amin, O; Ferrer, L; Marcovecchio, J


    For the first time the concentration of trace metals (Fe, Pb, Cu, Zn, Cd and total Hg) of sediments from the coastal zone of the Beagle Channel (Tierra del Fuego, in Southern Argentina) were measured. Atomic absorption spectrophotometry was utilized in order to determine the metal contents. The level of metals as observed in the sediments was recognized as the natural background, even though the use of normalization of lead, copper, and zinc to iron allowed the identification of the main sources of metal pollution for this environment. In order to develop future environmental monitoring programmes for the area of Ushuaia city and the Beagle Channel, the present results need to be considered.

  2. Baseline trace metals in gastropod mollusks from the Beagle Channel, Tierra del Fuego (Patagonia, Argentina). (United States)

    Conti, Marcelo Enrique; Stripeikis, Jorge; Finoia, Maria Grazia; Tudino, Mabel Beatriz


    With the aim to evaluate the mollusk Nacella (P)magellanica as biomonitor of elemental pollution in seawater of the Beagle Channel, more than one hundred individuals of the gastropod were sampled, separated in viscera and muscle, and then examined with respect to the accumulation of Cd, Cr, Cu, Ni, Pb and Zn. Collection was performed in seven strategic locations along 170 km of the coastal area of the Beagle Channel (Tierra del Fuego, Argentina) in two campaigns during 2005 and 2007. Samples of surrounding seawater in the different sites were obtained and tested for the same metals as well. The accumulation capacity of Nacella (P)magellanica and thus its aptitude as biomonitor, was evaluated through the calculus of the preconcentration factors of the metals assayed. A discussion involving the comparison with other mollusks previously tested will be given. Several statistical approaches able to analyze data with environmental purposes were applied. Non parametric univariate tests such as Kruskal-Wallis and Mann-Whitney were carried out to assess the changes of the metal concentrations with time (2005 and 2007) in each location. Multivariate methods (linear discriminant analysis on PCA factors) were also applied to obtain a more reliable site classification. Johnson's probabilistic method was carried out for comparison between different geographical areas. The possibility of employing these results as heavy metals' background levels of seawater from the Beagle Channel will be debated.

  3. Geomorphological evolution of a paraglacial coastal system: Moat Sector, Beagle Channel, Tierra de Fuego, Argentina (United States)

    Blanco-Chao, R.; Pérez-Alberti, A.; Martínez-Cortizas, A.; Valcárcel-Díaz, M.; Costa-Casais, M.


    The morphodynamics of paraglacial coastal systems is controlled by a number of factors, including rock basement structure, sediment disposal, changes in the relative sea-level and wave regime. Of great importance is the thickness and the particle size composition of the glacial deposits because they are not only the main source of material, but also a major element in the coast plan form and in the processes of sediment redistribution. The Moat sector in the Beagle Channel (Tierra del Fuego, Argentina), is a shallow embayment opened in a previously glaciated landscape, in which the Beagle glacier left several drumlins and moraines. After deglaciation the rising sea-level led to the erosion of the till sediments at least until 2550 yr BP, exposing the rock substrate in which up to three narrow shore platforms were modelled. The erosion of the till produced cliffs up to 18 m high, capped with Holocene sediments. After 2550 yr BP a fall in the relative sea-level enhanced wave dissipation on the rocky areas and forced the diffraction of the incoming waves. The limits of the sedimentary cell were then set and a shadow zone developed in the east section of the beach, where the cliff became stabilized meanwhile erosion persisted on the west section. The coarser till of the west cliff was then the main source of sediments, and the retreat of the cliff left a boulder pavement that created a secondary limit of the cell. The clasts were redistributed by a dominant west to east transport that still dominates today. The 14C dates obtained in the sedimentary deposit developed on top of the cliff suggest that, when the bluff retreat stopped at the east end, a phase of stabilization began and the talus was covered by a layer of organic-rich sediments. Later, an environmental change to drier conditions, occurred after 1310-1180 cal. yr BP, led to the desiccation and degradation of the organic-sediments of the talus, which started to be eroded exposing the till again

  4. Growth and production of the venerid bivalve Eurhomalea exalbida in the Beagle Channel, Tierra del Fuego (United States)

    Lomovasky, Betina J.; Brey, Thomas; Morriconi, Elba; Calvo, Jorge


    Growth, mortality and productivity of the hard clam Eurhomalea exalbida from Ushuaia Bay, Beagle Channel, were investigated. The parameters of the von Bertalanffy growth function were estimated to be H ∞ = 74 mm, K = 0.18 y -1, t 0 = 0.15 y. Maximum individual production amounted to 2.74 g shell-free wet mass (SFWM) at 49.5 mm shell height. Animals between 40 mm and 70 mm shell height contributed most to overall population somatic production P of 134 g SFWM m -2 y -1. Mean annual biomass B amounted to 1123 g SFWM m -2 y -1. Annual P/B ratio and mortality rate Z were estimated to be 0.12 y -1 and 0.14 y -1, respectively. Slow growth and low turnover make this population less suitable for sustainable commercial exploitation.

  5. Structure and dynamics of the biota associated with Macrocystis pyrifera (Phaeophyta from the Beagle Channel, Tierra del Fuego

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    Mariana L. Adami


    Full Text Available The community associated to the kelp Macrocystis pyrifera from the Beagle Channel (54°00´S; 68°20´W was studied. Sixty-eight taxa including Algae (5, Porifera (indet., Bryozoa (7, Nemertea (2, Annelida (10, Mollusca (22, Crustacea (15 and Echinodermata (7 were recognized. A seasonal sampling during one year showed differences in taxa composition when comparing (a two different environments; (b the spring-summer period and the autumn-winter period; and (c the parts of the alga (fronds and holdfast.

  6. Feeding habits of the false southern king crab Paralomis granulosa (Lithodidae in the Beagle Channel, Tierra del Fuego, Argentina

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    Laura Inés Comoglio


    Full Text Available Stomach contents of 282 false southern king crabs (Paralomis granulosa, between 10 to 90 mm CL from the Beagle Channel (Golondrina Bay and Roca Mora, Argentina, were examined by the frequency of occurrence method of analysis and by a food index. Roca Mora is an area where juveniles ( 60 mm CL are common; in this last area sexual segregation was also observed. The principal food groups for crabs of Golondrina Bay were algae, molluscs, crustaceans, bryozoans and foraminiferans; for crabs from Roca Mora the natural diet consisted of three major food groups: hydrozoans, echinoderms and foraminiferans. The relative frequency of different prey groups varied in relation to the size, season and sex. There were no significant differences in the quantity of food consumed by sexes in both areas. Generally small crabs ( 50 mm CL. Juveniles consumed a greater amount of food during winter and spring. In summer (moulting period, juveniles had the highest vacuity index. Adults consumed minor amounts of food during autumn, before the spawning-moulting-mating period when the vacuity index was higher (spring.

  7. Heavy metal concentrations and biomarkers of oxidative stress in native mussels (Mytilus edulis chilensis) from Beagle Channel coast (Tierra del Fuego, Argentina). (United States)

    Duarte, Claudia A; Giarratano, Erica; Amin, Oscar A; Comoglio, Laura I


    The aim of this study was to evaluate the usefulness of oxidative stress biomarkers of pollution in native mussels Mytilus edulis chilensis from the Beagle Channel. Spatial and seasonal variations of catalase, glutathione-S-transferase and lipid peroxidation in gills and digestive gland were analyzed in relation to environmental parameters, heavy metals in sediment and in tissue. Four sites with anthropogenic impact and a control site were selected and monitored during the four seasons of 2007. We found significant differences among sites in concentrations of dissolved nutrients and heavy metals in sediments, with the highest values recorded at sites with anthropogenic pressure. Different patterns were observed between concentrations of metals in tissues and in sediments suggesting differences in bioavailability. There were also significant differences in biomarker responses among sites, despite the strong seasonal variability. Our results showed relatively moderate levels of pollution in the study area as a result of urban influences. Copyright © 2011 Elsevier Ltd. All rights reserved.

  8. Paleoenvironmental interpretation of late Quaternary molluscan assemblages from southern South América: A taphonomic comparison between the Strait of Magellan and the Beagle Channel Interpretación paleoambiental de ensambles de moluscos del Cuaternario tardío del sur de América del Sur: una comparación tafonómica entre el Estrecho de Magallanes y el Canal Beagle

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    Javiera Cárdenas


    Full Text Available This study analyzes the Holocene molluscan assemblage in raised marine terraces along the coasts of the Strait of Magellan and the Beagle Channel. A total of 33 gastropods and 12 bivalves were identified. They constitute the first mollusk listing for deposits in the Strait of Magellan. Taphonomic analysis suggests a high energy environment with epifaunal elements in the Strait of Magellan and a low energy environment with the predominance of infaunal elements in the Beagle Channel. All the collected species are living taxa suggesting that postglacial climatic variations were not enough to alter the composition of the communities since at least 6,000 yr BP in the southern Chile-Argentina región.Este trabajo analiza los ensambles de moluscos del Holoceno de las terrazas marinas presentes a lo largo de las costas del Estrecho de Magallanes y del Canal Beagle. Un total de 33 especies de gastrópodos y 12 de bivalvos fueron identificados. Ellos constituyen un primer listado de moluscos para los depósitos del Estrecho de Magallanes. El análisis tafonómico sugiere un ambiente de alta energía con elementos epifaunales en el Estrecho de Magallanes y un ambiente de baja energía con el predominio de elementos infaunales para el Canal Beagle. Todas las especies colectadas son taxa vivientes, lo que sugiere que las variaciones climáticas postglaciales no fueron suficientes para alterar la composición de las comunidades desde al menos 6.000 años AP en el extremo austral de Chile-Argentina.

  9. Safety and tolerability of 0.1% tacrolimus solution applied to the external ear canals of atopic beagle dogs without otitis. (United States)

    Kelley, Laura S; Flynn-Lurie, Alison K; House, Rossi A; Simpson, Andrew C; Marsella, Rosanna


    Tacrolimus is a nonsteroidal alternative to treat noninfectious otitis externa (OE) in people. This 21-day study investigated whether twice daily application (0.2 mL/dose) of sterile olive oil based 0.1% tacrolimus suspension in ears of atopic beagle dogs without OE was associated with adverse local reactions, development of OE, change in otic cytology, vestibular dysfunction, or hearing loss detected by brainstem auditory evoked response (BAER). The study was randomized, double-blinded, and placebo-controlled. Twenty-two dogs matched for age and sex were randomized to tacrolimus or vehicle control treatment groups. Two investigators independently evaluated dogs for signs of adverse effects including OE the first 4 days of treatment, then every 3 days. A logistic regression model was fit for each investigator's clinical scores (SAS, 9.2, 2008). Time (P = 0.0032) and group (P = 0.0167) were always significant for OE. Inter-observer reliability of clinical scores was strong, measured using Kappa coefficients and proportion of agreement. All nine exclusions (7/10 control- and 2/12 tacrolimus-treated dogs) were excluded for yeast OE. Inter-observer agreement to exclude was 100%. All dogs not excluded had normal BAER assessments before treatment, weekly during treatment, and after 21 days of treatment. None showed vestibular abnormalities at these times. Tacrolimus blood concentrations (Abbott IMx Tacrolimus II) were below detection limits (3 ng/mL) at baseline and after 21 days of treatment. Results suggest otic application of olive oil based tacrolimus suspension to canine ears with intact tympanic membranes is unlikely to result in hearing loss or vestibular dysfunction but yeast OE is a possible risk. © 2010 The Authors. Journal compilation © 2010 ESVD and ACVD.

  10. Polo a Tierra


    Betancur, Ángela; Rojas, Juliana; Garcés, Daniela


    Polo a Tierra es un proyecto que busca reactivar el parque de bolsillo como lugar de encuentro de los ciudadanos a través de acciones Ecoartísticas. Estas acciones serán realizadas con los niños y sus núcleos familiares, para mejorar el aspecto del parque que actualmente se encuentra deterioro y fomentar la generación de vínculos con la comunidad para que este se mantenga activo como sitio de encuentro y como espacio de apropiación de prácticas ecológicas y culturales.

  11. Penis Allotransplantation in Beagle Dog

    National Research Council Canada - National Science Library

    Zhao, Yongbin; Hu, Weilie; Zhang, Lichao; Guo, Fei; Wang, Wei; Wang, Bangqi; Zhang, Changzheng


    This is an original research of penis allotransplantation. The paper presents an experiment allogenic penis transplantation model in Beagles, with a focus on recovery of blood supply and changes in tissue architecture...

  12. Penis Allotransplantation in Beagle Dog

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    Yongbin Zhao


    Full Text Available This is an original research of penis allotransplantation. The paper presents an experiment allogenic penis transplantation model in Beagles, with a focus on recovery of blood supply and changes in tissue architecture. Twenty adult Beagles were allocated to 10 pairs for penile transplantation. After operation, the skin and glans were observed. If adverse symptoms occurred, the transplanted penis was resected and pathologically examined. Frequency of urination, urinary stream, and patency level were recorded 7 days after transplantation. Cystourethrography was performed on Day 10. The transplanted penises were resected on Day 14 for pathological examination. The research showed that transplanted penises survived after allotransplantation, and the dogs regained urination ability. Penis autotransplantation in Beagles is feasible. This preliminary study shows a potential for application of this new procedure for penis transplantation in humans.

  13. Penis Allotransplantation in Beagle Dog. (United States)

    Zhao, Yongbin; Hu, Weilie; Zhang, Lichao; Guo, Fei; Wang, Wei; Wang, Bangqi; Zhang, Changzheng


    This is an original research of penis allotransplantation. The paper presents an experiment allogenic penis transplantation model in Beagles, with a focus on recovery of blood supply and changes in tissue architecture. Twenty adult Beagles were allocated to 10 pairs for penile transplantation. After operation, the skin and glans were observed. If adverse symptoms occurred, the transplanted penis was resected and pathologically examined. Frequency of urination, urinary stream, and patency level were recorded 7 days after transplantation. Cystourethrography was performed on Day 10. The transplanted penises were resected on Day 14 for pathological examination. The research showed that transplanted penises survived after allotransplantation, and the dogs regained urination ability. Penis autotransplantation in Beagles is feasible. This preliminary study shows a potential for application of this new procedure for penis transplantation in humans.

  14. BeagleBone media center

    CERN Document Server

    Lewin, David


    Whether you are a hobbyist or a professional, this book will get you fully equipped to resolve the most commonly occurring media-related challenges. If you want to expand your horizons beyond lighting an LED and push the limits of your board, this is just the book for you. Working knowledge of BeagleBone is assumed.

  15. La Nueva Sociedad de la Tierra Plana


    Bartlett, Albert A.


    Hubo un tiempo, hace mucho, en el que la gente pensaba que la Tierra era plana, pero ahora, durante algunos siglos, la gente ha creído que la Tierra es redonda... como una pelota. Pero hay problemas con una Tierra redonda, y por ello está emergiendo un nuevo y actual paradigma, que parece un regreso a la sabiduría de los antiguos.Una esfera es curva y por lo tanto es finita, lo que implica que hay límites, y en particular hay límites al crecimiento de cosas que consuman partes de la Tierra y ...

  16. La Memoria De Nuestra Tierra: Colorado (United States)

    Baca, Judy


    La Memoria de Nuestra Tierra combines a meticulously hand-painted landscape with historic photographs in a seamless blend imprinted on the holographic-like surface of a metallic coated substrate. The mural for the Denver International Airport, entitled La Memoria de Nuestra Tierra is a breakthrough in digital murals, printed digitally on a…

  17. Ontogenetic allometry of the Beagle. (United States)

    Helmsmüller, Daniela; Wefstaedt, Patrick; Nolte, Ingo; Schilling, Nadja


    Mammalian juveniles undergo dramatic changes in body conformation during development. As one of the most common companion animals, the time line and trajectory of a dog's development and its body's re-proportioning is of particular scientific interest. Several ontogenetic studies have investigated the skeletal development in dogs, but none has paid heed to the scapula as a critical part of the mammalian forelimb. Its functional integration into the forelimb changed the correspondence between fore- and hindlimb segments and previous ontogenetic studies observed more similar growth patterns for functionally than serially homologous elements. In this study, the ontogenetic development of six Beagle siblings was monitored between 9 and 51 weeks of age to investigate their skeletal allometry and compare this with data from other lines, breeds and species. Body mass increased exponentially with time; log linear increase was observed up to the age of 15 weeks. Compared with body mass, withers and pelvic height as well as the lengths of the trunk, scapula, brachium and antebrachium, femur and crus exhibited positive allometry. Trunk circumference and pes showed negative allometry in all, pelvis and manus in most dogs. Thus, the typical mammalian intralimb re-proportioning with the proximal limb elements exhibiting positive allometry and the very distal ones showing negative allometry was observed. Relative lengths of the antebrachium, femur and crus increased, while those of the distal elements decreased. Beagles are fully-grown regarding body height but not body mass at about one year of age. Particular attention should be paid to feeding and physical exertion during the first 15 weeks when they grow more intensively. Compared with its siblings, a puppy's size at 9 weeks is a good indicator for its final size. Among siblings, growth duration may vary substantially and appears not to be related to the adult size. Within breeds, a longer time to physically mature is

  18. UK and ESA announce Beagle 2 inquiry

    CERN Multimedia


    An investigation will be held to identify the potential reasons surrounding the inability to communicate with the British-led Beagle 2 lander once it parted from the mother ship on Christmas day (1 page).

  19. Construcciones a base de tierra

    Directory of Open Access Journals (Sweden)

    Alvarez Alonso, Marina


    oriented towards dissipating possible prejudices which exist with regard to earthen constructions.Trabajo realizado y basado en las nuevas posibilidades de las construcciones con tierra, una vez considerado su interés en épocas anteriores y las nuevas posibilidades que ofrece ante la crítica impuesta por la crisis de la energía. Se hacen consideraciones sobre las necesidades de vivienda previstas hasta el año 2000 y otros parámetros que vuelven a ser importantes al confrontarlos económicamente con los materiales industrializados, sistemas de construcción, soluciones orientadas a los países en vías de desarrollo, etc. Continúa el trabajo con las primeras vías de experimentación práctica desarrolladas por el equipo de trabajo de viviendas de bajo coste orientadas a la búsqueda y promoción de recursos locales y abundantes como el material tierra, vías de experimentación que comienzan con el conocimiento por el equipo de técnicas y materiales durante el curso realizado en Ciadueña (Soria. Se describen aspectos técnicos del material tierra desarrollados paralelamente a la experiencia práctica inicial y orientada a la elección idónea de los componentes, una vez confrontada la información bibliográfica relacionada con el tema. Entre las consideraciones técnicas se llega a una exposición más exhaustiva sobre: 1 Las técnicas existentes: ladrillos de adobe, tierra apisonada (tapial, etc. 2 Porcentajes idóneos de los componentes para la elección de los materiales preferibles en cada una de las técnicas anteriores. 3 Consideraciones de los aspectos físicos y mecánicos de la maquinaria existente y en experimentación, así como de las posibilidades respecto a su puesta en obra, costes comparativos, etc. 4 Estudio de las posibilidades para mejorar las características del material tierra mediante diferentes técnicas de estabilización (compactación y correcciones granulométricas, estabilizantes fisicoquímicos, betunes, productos

  20. Arquitectura de tierra contemporanea: tendencias y desafios

    National Research Council Canada - National Science Library

    Rotondaro, Rodolfo


    Arquitecto recibido en la Universidad Nacional de Mar del Plata, Argentina (1980), con titulo de magister del Centro Internacional de la Construccion en Tierra, craterre, de la Escuela de Arquitectura de Grenoble, Francia...

  1. Bloque de tierra comprimida como material constructivo

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    Óscar Javier Gutiérrez Junco


    Full Text Available La construcción con tierra es poco usada en la actualidad debido a la falta de difusión e investigación, y a que es relacionada con la pobreza; por ende, se desaprovechan muchas de sus ventajas, como la abundancia demateria prima, la localización, la disponibilidad, el reciclaje, la producción sin consumo de energía (calorífica, el bajo costo y la resistencia –con un adecuado estudio del material tierra, de la estructuración y del suelo de fundación–; otras de sus ventajas son el aislamiento térmico y acústico. Con el paso del tiempo se han mejorado las técnicas constructivas con tierra, realizando estabilizaciones e implementando el uso de maquinaria y herramienta mecánica para elaborar bloques de tierra comprimida, y así facilitar el trabajo y obtener mayor rendimiento. Este artículo presenta la tierra como material constructivo, las técnicas o sistemas constructivos, los bloques de tierra comprimida (BTC y algunos ensayos realizados a estos bloques.

  2. canal24 (United States)

    California Department of Resources — Canal system center lines in the Central Valley of California and adjacent areas captured from 1:24,000-scale USGS topographic maps. Updates and modifications made...

  3. Análisis comparativo osteológico y dentario de dos cazadores tardíos de fauna marina de Isla Grande de Tierra del Fuego, Argentina

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    Kozameh, Livia Febes


    Full Text Available De una fosa excavada en un conchero, al este de la ciudad de Ushuaia, sobre el Canal Beagle, fueron exhumados, de un entierro primario, restos de un esqueleto humano casi completo. El resto se halló asociado a un raspador de vidrio, elemento por el que se lo asignaría a momentos tardíos. Estos restos corresponden a un adulto masculino de avanzada edad a la muerte. En excavaciones realizadas en Bahía Valentín, Península Mitre, extremo sudoriental de la Isla Grande de Tierra del Fuego, fue encontrado, entre otros restos, un esqueleto completo de un individuo masculino, adulto maduro al momento de la muerte. Entre los hallazgos obtenidos en el área fueron recuperados, entre otros, restos industriales europeos, posiblemente productos de naufragios. Esta evidencia avalaría su ubicación temporal en momentos posteriores a la llegada de los europeos. El objetivo de este trabajo ha sido realizar un análisis comparativo de rastros fisiológicos y patológicos del esqueleto y del aparato masticatorio, en ambos ejemplares. Este análisis revela marcadas diferencias entre ambos restos, que refieren tanto a su distribución esqueletal como asimismo a la intensidad de la injuria. Contar con dos esqueletos de características afines posibilitó el estudio comparativo. El análisis de los resultados señala diferencias del estado de salud y enfermedad en uno y otro cazador. Esas diferencias se manifiestan tanto en el esqueleto post-craneano como, muy especialmente, en el aparato masticatorio.

  4. Chlorophyll and zooplankton in microbasins along the Strait of Magellan - Beagle Channel passage

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    Madeleine Hamamé


    Full Text Available Distributions of chlorophyll and zooplankton were compared to temperature and salinity distributions along previously defined microbasins. Results were consistent for chlorophyll: 1.- Paso Ancho-Seno Magdalena showed a shallow chlorophyll maximum (ca. 5 mg m-3 at 0 - 20 m in a vertically homogeneous cold and brackish water column, 2.- Canal Magdalena-Canal Cockburn-Canal Brecknock had relatively lower chlorophyll concentrations (2-3 mg m-3 at 0-50 m, minor stratification of salinity and a surface lens of warmer water, 3.- Canal Ballenero-Brazo Noroeste had a subsurface layer of high chlorophyll concentration (> 4 mg m-3 in a vertically stratified water column of 2 salinity layers and 3 temperature layers, 4.- Canal Beagle presented a subsurface chlorophyll maximum (> 4 mg m-3 extending to the bottom, and vertically homogeneous salinity and temperature distribution. Chaetoceros spp.-dominated phytoplankton was a common feature in the entire area. Zooplankton distributions did not match the above mentioned subdivision of microbasins despite some trends along the passage. High relative abundance of invertebrate larvae in the zooplankton was associated with a matching response to the spring bloom and implies a strong bentho-pelagic coupling.

  5. Ecologia de las lombrices de tierra (United States)

    Grizelle Gonzalez


    De los organismos de suelo, las lombrices de tierra son las mas conocidas y a menudo son consideradas las mas importantes por su influencia en el funcionamiento de ecosistemas de suelo (Hendriz y Bohlen, 2002). Tienen un efecto significativo en la estructura del suelo, el ciclo de nutrimentos y ls productividad de las cosechas. En terminos de biomasa, generalmente...

  6. BeagleBone for secret agents

    CERN Document Server

    Datko, Josh


    If you have some experience with the BeagleBone or similar embedded systems and want to learn more about security and privacy, this book is for you. Alternatively, if you have a security and privacy background and want to learn more about embedded development, this book is for you. You should have some familiarity with Linux systems and with the C and Python programming languages.

  7. A second, cryptic species of the soft coral genus Incrustatus (Anthozoa: Octocorallia: Clavulariidae) from Tierra del Fuego, Argentina, revealed by DNA barcoding (United States)

    McFadden, Catherine S.; van Ofwegen, Leen P.


    The encrusting soft coral Incrustatus comauensis is a common denizen of hard substrates in the shallow sub-tidal zone from the central Chilean fjords to the Cape Horn region of southern South America. DNA barcoding of specimens collected from the Beagle Channel, Tierra del Fuego, Argentina, revealed the presence of a second, cryptic species of Incrustatus that is syntopic with I. comauensis. We describe Incrustatus niarchosi, a new species that can be distinguished morphologically from I. comauensis by differences in the microscopic ornamentation of the coenenchymal sclerites. To date, I. niarchosi n. sp. is known only from the Beagle Channel. A population of I. comauensis discovered in the intertidal zone in eastern Tierra del Fuego represents a new record of the species for that habitat and geographic region. Although the intertidal population is also distinct genetically, it is morphologically indistinguishable from sub-tidal Chilean populations of I. comauensis, and at present, there is insufficient evidence to support its status as a separate species.

  8. Tierra Nueva -- A passive solar cohousing project

    Energy Technology Data Exchange (ETDEWEB)

    Haggard, K.; Cooper, P.


    California architects take on the formidable challenges of designing a cohousing project, and discover that the end result is well worth the effort. The Tierra Nueva Cohousing Project consists of living units, a common house, community orchard, community gardens, community play space, space for a future shop and at the periphery of the site, parking, carports and garages. The units use thermal mass, solar heating, passive solar cooling, perimeter insulation on slabs. Design was agreed to by the community as a whole.

  9. Preliminary Investigation of Beagle Dog as Substitute for Humans in ...

    African Journals Online (AJOL)

    Purpose: To assess the suitability of beagle dog as an animal model for the evaluation of formulations in bioavailability and bioequivalence studies. Methods: A generic cetirizine 10 mg tablet formulation was compared with another reference formulation using beagle dog as animal model. A crossover oral comparative ...

  10. Baseline trace metals in bivalve molluscs from the Beagle Channel, Patagonia (Argentina). (United States)

    Conti, Marcelo Enrique; Stripeikis, Jorge; Finoia, Maria Grazia; Tudino, Mabel Beatriz


    In order to test the aptitude of individuals of Mytilus chilensis as biomonitors of heavy metals pollution in seawater, several samples of this mollusk together with surrounding seawater samples were collected along 170 km of the coastal area of the Beagle Channel (Tierra del Fuego, Argentina) in 2005 and 2007. The study, performed in seven locations strategically selected, involved the determination of Cd, Cr, Cu, Ni, Pb and Zn in seawaters and mollusks by atomic absorption spectrometry (AAS) and the calculation of the respective concentration factors (CFs). Obtained data were standardized and analyzed by multivariate techniques in order to establish differences between sampling sites and periods. Obtained results will be shown and the bioaccumulation ability of M. chilensis will be evaluated by comparison with results obtained for Mytilus species in different geographical marine areas. A fully discussion on the possibility of employing the results as background levels for comparative purposes in other marine waters of the world will be provided. The possible harm derived from human consumption of these mollusks will be also assessed.

  11. The Geologic and Geochemical Setting of Lago Fagnano, Tierra del Fuego, Argentina (United States)

    Tingle, D.; Odle, K.; Knettel, P.; Redding, S.; Perry, E.; Ellins, K.; Ormiston, C.; Dovzak, N.; Anderson, S.


    Lago Fagnano, Tierra del Fuego, Argentina is the largest and southernmost ice-free lake on Earth. The isolated lake is unique because the geographic and geologic context provides information relating to the westerly wind patterns, interaction of multiple water sources (hot springs, glacial meltwater, precipitation, groundwater), and tectonic dynamics along a major transform fault. In March, 2005, four students and three teachers from Boerne High School, south-central Texas joined scientists from the United States, Argentina and Switzerland engaged in a geophysical survey of this lake. Lago Fagnano potentially contains within its sediments an undisturbed record of the geotectonic and global climate variability of past 20,000 years. The science team imaged the lake floor with a boat specially equipped to collect both high resolution data (high frequency), imaging the upper 10-15 meters of the sediment, and long range data (low frequency), penetrating 100 or more meters into the sediment. The group conducted field research of existing tectonic features at the eastern end of Tierra del Fuego, an activity directly tied to the research objectives of the science team. They also collected water and soil samples to assess chemical and isotopic trends in the Lago Fagnano region. The research performed can help to characterize the modern geochemical setting of the lake. Analyses of dissolved oxygen, NH4+, PO42-, pH (water) and N, P, and pH (soils) demonstrate a link between low nutrient levels and low biodiversity (which was confirmed by observation) in Tierra del Fuego. Water and soil data are incorporated into a database to facilitate comparisons to North American samples collected and analyzed during the Boerne High School summer field courses. Twenty-three ^18O and ^D analyses yielded a south-north isotopic trend across the Lago Fagnano region. ^18O and ^D transition from -11.92 to -3.53% and -87.81 to -40.26%, respectively, moving south to the Beagle Channel. These

  12. Neoplasia in fast neutron-irradiated beagles

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, E.W.; Zook, B.C.; Casarett, G.W.; Deye, J.A.; Adoff, L.M.; Rogers, C.C.


    One hundred fifty-one beagle dogs were irradiated with either photons or fast neutrons (15 MeV) to one of three dose-limiting normal tissues--spinal cord, lung, or brain. The radiation was given in four fractions per week for 5 weeks (spinal cord), 6 weeks (lung), or 7 weeks (brain) to total doses encompassing those given clinically for cancer management. To date, no nonirradiated dogs or photon-irradiated dogs have developed any neoplasms. Seven dogs receiving fast neutrons have developed 9 neoplasms within the irradiated field. Of the neutron-irradiated dogs at risk, the incidence of neoplasia was 15%. The latent period for radiation-induced cancers has varied from 1 to 4 1/2 years at this time in the study.

  13. Neoplasia in fast neutron-irradiated beagles

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, E.W. (George Washington Univ. Medical Center, Washington, DC); Zook; B.C.; Casarett, G.W.


    One hundred fifty-one beagle dogs were irradiated with either photons or fast neutrons (15 MeV) to one of three dose-limiting normal tissues - spinal cord, lung, or brain. The radiation was given in four fractions per week for 5 weeks (spinal cord), 6 weeks (lung), 7 weeks (brain) to total doses encompassing those given clinically for cancer management. To date, no nonirradiated dogs or photon-irradiated dogs have developed neoplasms within the irradiated field. Of the neutron-irradiated dogs at risk, the incidence of neoplasia was 15%. The latent period for radiation-induced cancers has varied from 1 to 4 1/2 years at this time in the study.

  14. Gynaecomastia in male beagle dog after application of steroidal androgen


    Lüdtke-Handjery, Oliver Martin


    Introduction: Male beagle dogs treated daily dermally for 4 and 39 weeks with a synthetic androgen developed alterations of the breast in the sense of a gynecomastia. The well-known mechanism of gynecomastia in man as well as the mechanism identified for the bitch during estrus cycle were considered to identify which mechanism is responible for the mammary changes. Material and Methods: Formalin fixed and paraffin embedded mammary gland tissue of 64 male beagle dog were examined for...

  15. Tierra Caliente, Michoacán

    Directory of Open Access Journals (Sweden)

    C. I. Villa


    Full Text Available Los sistemas de producción ganaderos de la región de Tierra Caliente están vinculados al manejo agrosilvopastoril, aprovechando una amplia gama de recursos forrajeros naturales, siendo las familias quienes conducen la administración y aprovechamiento de dichos recursos. Se buscó definir las características, recursos forrajeros aprovechables e insumos alimenticios, estimando su calidad nutricional, con el fin de encontrar estrategias de alimentación de ganado que reduzcan al mínimo el uso de insumos externos al interior de las unidades productivas. Se trabajó en comunidades del municipio de Tuzantla, en la región de Tierra Caliente del estado de Michoacán. El método incluye la recolección de información por medio de encuestas aplicadas a productores campesinos, durante el ciclo productivo 2007. Se analizaron de 200 a 300 g de 41 muestras de alimentos con el método de Wendee, para analizar su composición química. Se encontró que para la región de Tierra Caliente existe un sistema de producción bovina de mediana escala, semi-estabulado y trashumante que, en promedio, tiene 250 a 260 ha y 86 cabezas de ganado destinado a la producción de carne y pie de cría, y que producen 9.2 l/vaca/día; con esta leche se elabora queso a razón de 1kg de queso por cada 10 litros de leche. Se identificó, también, el uso de seis ingredientes fundamentales que componen dos dietas básicas, cuya composición química detectada fue de 10.2- 13.9% (PC, 7.9-11.8% (FC, 62.8-67.9% (ELN, 1.4-5% (EE y 1.9-8.8% (cenizas. Por tanto, se concluye que los ganaderos cubren los requerimientos nutricionales con base en el alto uso de concentrados, dejando los forrajes para satisfacer las necesidades de consumo de su ganado. Por esto, se requiere establecer un sistema de balanceo de raciones que permita optimizar los recursos

  16. Darwin, el Planeta Tierra, las otras tierras y los profesores de ciencias

    Directory of Open Access Journals (Sweden)

    Francisco Anguita Virella


    Full Text Available Las conmemoraciones ofrecen oportunidades didácticas. En 2009 han coincidido las referidas a Darwin y a Galileo, que casi han solapado con la declaración de 2008 como el Año Internacional del planeta Tierra. Aparentemente heterogéneas, estas celebraciones presentan un hilo conductor común, útil para una reflexión de fondo sobre la enseñanza de la Ciencia en la Educación Secundaria.

  17. El Año Internacional del Planeta Tierra


    Calvo Sorando, José Pedro


    La propuesta de organizar la conmemoración de un Año Internacional del Planeta Tierra fue lanzada, en 2001, por la Unión Internacional de Ciencias Geológicas (IUGS), conjuntamente con la División de Ciencias de la Tierra de la UNESCO. Unos años después, en Diciembre de 2005, la Asamblea General de Naciones Unidas ha proclamado oficialmente 2008 como Año Internacional del Planeta Tierra. Múltiples países están apoyando esta iniciativa que, en realidad, se desarrollará como un trienio de activi...

  18. El recurso tierra en Costa Rica

    Directory of Open Access Journals (Sweden)

    Floria Bertsch


    Full Text Available En este artículo se presenta un análisis sistemático de la evolución del recurso tierra durante los últimos 10 años, desde diferentes perspectivas: las instituciones involucradas en su manejo, su uso actual y potencial, la actividad agropecuaria que sustenta dicho recurso a través de diferentes mundos agrícolas, y algunas otras opciones de agricultura sostenible que han surgido recientemente como es la agricultura orgánica. También se analiza el urbanismo, como aquella presión que efectúa la población sobre el recurso, y se discuten algunas alternativas de conservación planteadas a nivel nacional. Como conclusiones de la autora, en términos generales, el tema adolece de falta de información confiable desde hace 20 años, hay una clara tendencia al paso de la tierra de pequeños a más grandes propietarios y un incremento en la “peonización” a partir de la pérdida de la propiedad. El país se dirige hacia una clara dependencia de la compra en mercados extranjeros para la alimentación básica, a pesar de la existencia de nuevas opciones tecnológicas. Existen avances importantes en legislación pero aún están a nivel de papel y en términos urbanísticos, la presión social vence el ordenamiento territorial.

  19. [Experimental study on pulp revitalization of Beagle dog's immature permanent teeth after pulpectomy]. (United States)

    Yang, Jian-zhen; Ouyang, Yong; Liao, Zhi-qing


    To observe the process of pulp revitalization of immature permanent teeth after pulpectomy. Thirty-two single-rooted teeth with open apices from 4 Beagle dogs aged 4 months were included in the study. The pulpal tissues of 8 front teeth with single root of each dog were removed, and a blood clot was produced to the level of the cementoenamel junction followed by a double seal of mineral trioxide aggregate and composite resin. At day 7, 14, 21 and 28, respectively after operation, the dog was sacrificed, and then longitudinal paraffin sections were made for histologic investigation. After 7 days, about one thirth of the pulp chamber had an ingrowth of new tissue. After 14, 21, 28 days, there were more and more new tissue in the chamber. This new tissue consisted of well-organized and well-vascularized connective tissue. Hard tissue was too observed in the root canal. In some cases, the newly generated hard tissue even deposited against the canal dentinal walls. The pulp of immature permanent teeth can revitalize after removal of the original pulp tissue under suitable conditions.

  20. Atrioventricular Canal Defect (United States)

    ... tract infections. Atrioventricular canal defect can cause recurrent bouts of lung infections. Heart failure. Untreated, atrioventricular canal ... Leaky heart valves Narrowing of the heart valves Abnormal heart rhythm Breathing difficulties associated with lung damage ...


    Directory of Open Access Journals (Sweden)

    Eric Richters


    Full Text Available El título de este evento es "El desarrollo y los límites de las tierras agrícolas utilizables en Costa Rica". En mi charla quiero dedicarme al aspecto general de cómo manejaremos las tierras, y esto en su contexto histórico. El objetivo de mi ponencia es aclarar nuestro acercamiento actual hacia la tierra en general y hacia la tierra rural en particular; los problemas de degradación de la misma, y también es mi deseo el dejar a ustedes algunas preguntas sobre un posible "involucramiento" del Estado en la solución de la problemática.

  2. Kidney disease in beagles injected with polonium-210

    Energy Technology Data Exchange (ETDEWEB)

    Bruenger, F.W.; Lloyd, R.D.; Taylor, G.N.; Miller, S.C.; Mays, C.W. (Univ. of Utah School of Medicine, Salt Lake City (USA))


    An unusually high incidence of kidney disease (tubular degeneration and necrosis with fibrous replacement) was observed among 24 beagles injected at about 5 years of age with 116 or 329 kBq 226Ra kg-1 but not among an additional 10 beagles given about 39 kBq 226Ra kg-1. This 226Ra solution also contained 210Pb, 210Bi, and 210Po. To determine whether the kidney disease was related to the radiation from 226Ra and its short-lived progeny or to the alpha radiation from 210Po, 2 beagles about 7 years of age were injected with 451 kBq 226Ra kg-1 of 210Po citrate. Measurements of polonium retention in the kidneys of 4 additional beagles given 210Bi citrate enabled us to model the retention of these emitters in the dog kidney and to estimate the kidney dose from the alpha radiation of 210Po following injection of either 226Ra + 210Bi + 210Po or 210Po only. Autoradiography revealed that almost equal concentrations of 210Po were in the tubular epithelium and/or its basement membrane and in the glomeruli, but very little of the 210Bi deposited in kidney tissue was present in the glomeruli. Radiation damage to the kidneys similar to that observed previously in beagles given 226Ra solutions that also contained 210Bi and 210Po was seen among the beagles given 210Po but not in the dogs given purified 226Ra. The analysis of these data indicated that the relatively high incidence of kidney disease among the mature beagles injected with 226Ra and its accompanying 210Bi and 210Po resulted from alpha irradiation of the kidneys by the substantial amount of 210Po that was in the injection solution.

  3. Acute monocytic leukemia in an irradiated beagle

    Energy Technology Data Exchange (ETDEWEB)

    Tolle, D.V.; Seed, T.M.; Fritz, T.E.; Lombard, L.S.; Poole, C.M.; Norris, W.P.


    A purebred female Beagle dog that had received 2,000 R of protracted whole-body ..gamma..-irradiation from /sup 60/Co when 14 months old had hematologic changes consistent with a myeloproliferative disorder 3 years after the termination of radiation exposure. Peripheral blood and bone marrow findings during the 7-month period before death showed progressive anemia with increased numbers of platelets; immature granulocytes, monocytes and promonocytes. A period of partial remission occurred during which time the peripheral blood was aleukemic, although there was marked thrombocytosis and abnormal erythropoiesis which was evidenced by bizarre circulating nucleated red cells, anisocytosis, poikilocytosis and Howell-Jolly bodies. The dog had a terminal crisis with marked leukocytosis, most cells in the peripheral blood being bizarre monocytes and promonocytes. Tissues obtained at necroscopy showed diffuse as well as focal infiltration of the spleen, liver, lymph nodes, heart, kidney and gastrointestinal wall with immature neoplastic cells resembling monocytes and monocytic precursors. The monocytic differentiation of the invasive cell population was confirmed by morphological, cytochemical, histological, ultrastructural and in vitro cell culture studies.

  4. Evaluation of nanoparticle delivered cisplatin in beagles (United States)

    Feldhaeusser, Brittany; Platt, Simon R.; Marrache, Sean; Kolishetti, Nagesh; Pathak, Rakesh K.; Montgomery, David J.; Reno, Lisa R.; Howerth, Elizabeth; Dhar, Shanta


    Intracranial neoplasia is a significant cause of morbidity and mortality in both human and veterinary patients, and is difficult to treat with traditional therapeutic methods. Cisplatin is a platinum (Pt)-containing chemotherapeutic agent approved by the Food and Drug Administration; however, substantial limitations exist for its application in canine brain tumor treatment due to the difficulty in crossing the blood-brain barrier (BBB), development of resistance, and toxicity. A modified Pt(iv)-prodrug of cisplatin, Platin-M, was recently shown to be deliverable to the brain via a biocompatible mitochondria-targeted lipophilic polymeric nanoparticle (NP) that carries the drug across the BBB and to the mitochondria. NP mediated controlled release of Platin-M and subsequent reduction of this prodrug to cisplatin allowed cross-links to be formed with the mitochondrial DNA, which have no nucleotide excision repair system, forcing the overactive cancer cells to undergo apoptosis. Here, we report in vitro effects of targeted Platin-M NPs (T-Platin-M-NPs) in canine glioma and glioblastoma cell lines with results indicating that this targeted NP formulation is more effective than cisplatin. In both the cell lines, T-Platin-M-NP was significantly more efficacious compared to carboplatin, another Pt-based chemotherapy, which is used in the settings of recurrent high-grade glioblastoma. Mitochondrial stress analysis indicated that T-Platin-M-NP is more effective in disrupting the mitochondrial bioenergetics in both the cell types. A 14-day distribution study in healthy adult beagles using a single intravenous injection at 0.5 mg kg-1 (with respect to Platin-M) of T-Platin-M-NPs showed high levels of Pt accumulation in the brain, with negligible amounts in the other analyzed organs. Safety studies in the beagles monitoring physical, hematological, and serum chemistry evaluations were within the normal limits on days 1, 7, and 14 after injection of either 0.5 mg kg-1 or 2 mg kg

  5. Hyperparasitism of the cryptoniscid isopod Liriopsis pygmaea on the lithodid Paralomis granulosa from the Beagle Channel, Argentina. (United States)

    Lovrich, Gustavo A; Roccatagliata, Daniel; Peresan, Laura


    A total of 29,570 false king crab Paralomis granulosa were sampled from the Beagle Channel (54 degrees 51'S, 68 degrees 12'W), Tierra del Fuego, Argentina, between July 1996 and August 1998. Crab size varied from 6.8 to 111.2 mm carapace length (CL). A few crabs parasitized by the rhizocephalan Briarosaccus callosus were found; prevalences of externae (the rhizocephalan reproductive body) and scars (the mark left on the host after the death of the parasite) were 0.28 and 0.16%, respectively. Of 85 externae examined, 55 were non-ovigerous and 30 ovigerous. The cryptoniscid isopod Liriopsis pygmaea infested 36.5% of the B. callosus examined. The most abundant stage was the cryptonicus larva, accounting for 208 of the 238 L. pygmaea recovered. Cryptonisci showed a highly aggregated distribution. A total of 92.7% of cryptonicsci were recovered inside empty externae, suggesting that the latter were attractive to cryptonisci. Early subadult females of L. pygmaea were rare; only 3 individuals occurred inside 1 ovigerous externa. Eight late subadult and 18 adult females were found on 3 and 7 non-ovigerous externae, respectively; in addition, 1 aberrant late subadult was found on 1 ovigerous externa. In the Beagle Channel, the population of P. granulosa harbours 3 different parasites: the bopyrid isopod Pseudione tuberculata, which reaches highest prevalence at 10 to 20 mm CL, the rhizocephalan B. callosus, with highest prevalence at 20 to 40 mm CL, and the cryptoniscid isopod L. pygmaea, which mainly infests rhizocephalan on crabs >40 mm CL.

  6. Inferencias paleodietarias mediante isótopos estables en restos óseos humanos provenientes de Tierra del Fuego, Argentina

    Directory of Open Access Journals (Sweden)

    Schinder, Gala


    Full Text Available Las actuales lineas de acción vinculadas al uso de isótopos estables en la Isla Grande de Tierra del Fuego están orientándose a acotar factores de variación (especialmente la variación espacial y temporal y al cruce con otras lineas de evidencias como los estilos de vida. A partir de la ocupación europea en el Siglo XVIII se modificó el estilo de vida de las poblaciones históricas de la región. El presente trabajo tiene como objetivos explorar la variabilidad en cuanto al tipo de recursos consurnidos por hombres y mujeres a partir de la información isotópica obtenida de huesos de individuos provenientes de diferentes sectores geográficos (Norte, Sudeste y Beagle y la determinación de la composición de la dieta en términos de contenido proteico. Los datos isotópicos se complementaron con información etnográfica. El análisis Kruskal-Wallis sugiere que existen diferencias significativas entre los diferentes sectores geográficos, pero no se registraron diferencias significativas entre hombres y mujeres. Asimismo, los isótopos indican que los individuos del Sudeste consumían preferentemente dietas más ricas en proteínas que sus vecinos del norte de la Isla. En los últimos años, ha crecido el interé por los estudios orientados al análisis de la división sexual del trabajo en sociedades cazadoras recolectoras. Este trabajo constituye un primer aporte para evaluar la variabilidad en cuanto a las diferencias en la obtención de recursos entre sexos y el tipo de dieta en individuos históricos de Tierra del Fuego.

  7. Pharmacokinetics of tildipirosin in beagle dogs. (United States)

    Wang, J; Zhao, T; Sun, X; Liu, Y; Zhu, J; Zhang, S; Cao, X


    The objective of this study was to investigate the pharmacokinetic profile of tildipirosin (TD) in 24 beagle dogs following intravenous (i.v.) and intramuscular (i.m.) administration, respectively, at 2, 4, and 6 mg/kg. Plasma samples at certain time points (0-14 days) were collected, and the concentrations of drug were quantified by UPLC-MS/MS. Plasma concentration-time data and relevant parameters were described by noncompartmental through WinNonlin 6.4 software. After single i.m. injection at 2, 4, and 6 mg/kg body weight, mean maximum concentration (Cmax ) was 412.73 ± 76.01, 1,051 ± 323, and 1,061 ± 352 ng/ml, respectively. Mean time to reach Cmax was 0.36 ± 0.2, 0.08 ± 0.00, and 0.13 ± 0.07 hr after i.m. injection at 2, 4, and 6 mg/kg, respectively. The mean value of T1/2λz for i.m. administration at doses of 2, 4, and 6 mg/kg was 71.39 ± 28.42, 91 .33 ± 50.02, and 96.43 ± 45.02 hr, respectively. The mean residence times were 63.81 ± 10.96, 35.83 ± 15.13, and 38.18 ± 16.77 hr for doses of 2, 4, and 6 mg/kg, respectively. These pharmacokinetic characteristics after i.m. administration indicated that TD could be rapidly distributed into tissues on account of the high lipid solubility and then released into plasma. In addition, the absolute bioavailability of 2 mg/kg after i.m. injection was 112%. No adverse effects were observed after i.v. and i.m. administration. © 2017 John Wiley & Sons Ltd.

  8. Glacial geomorphology of the Pleistocene Lake Fagnano ice lobe, Tierra del Fuego, southern South America (United States)

    Coronato, A.; Seppälä, M.; Ponce, J. F.; Rabassa, J.


    A regional geomorphological study is presented of the southern and eastern coast of Lake Fagnano, one of the most extensive glacial areas of Tierra del Fuego Island, at the southernmost tip of South America. A palaeoglacial reconstruction is made, based on the location of erosional and depositional glacial landforms. The outlet glacier flowing eastwards from the Darwin Cordillera (Fuegian Andes, Chile) had more than 50 tributary glaciers. An alpine-type landscape, including arêtes, cirques, truncated spurs and hanging valleys developed in the western region of the present lake, whereas a piedmont-type landscape including lateral moraines, glaciofluvial and glaciolacustrine terraces and an ice-disintegration landscape developed in the eastern region. The glacier spread over the low ranges and lowlands through three different lobes, and was drained by four main outwash basins, directly into the Atlantic Ocean. The ice-covered area is estimated at 4000 km 2; the maximum length of the main lobe at 132 km, and the general slope at 8°. Four terminal positions of the glacier were recognized and related to the Inútil Bay and Beagle Channel glacial areas, located to the north and south, respectively. 14C dates from basal peats show that most of the area, especially the easternmost part and the southern coast, were free of ice by 12,300 years B.P. Fossil peat contained in the lower basal till deposits yield 14C dates of 31,000-48,200 years B.P., indicating that a glacial advance occurred in the area prior to the Last Glacial Maximum (ca. 25,000-23,000 cal. years B.P.).

  9. Mars orbiter redirected in bid to find Beagle

    CERN Multimedia


    "Mission controllers in Darmstadt, Germany, have successfully redirected Europe's Mars Express orbiter into a polar orbit, putting it on course for a last-ditch attempt to contact Beagle 2, the lander that has been missing since Christmas day when it should have touched down on the red planet" (1/2 page).

  10. Monstrilloida (Crustacea: Copepoda) from the Beagle Channel, South America

    NARCIS (Netherlands)

    Suárez-Morales, E.; Ramírez, F.C.; Derisio, C.


    Monstrilloid copepods were collected during zooplankton surveys in the Beagle Channel at the southernmost end of South America. These specimens represent two species of Monstrillopsis, one of them undescribed, and one new species of Monstrilla. Monstrillopsis igniterra n. sp. is related to forms of

  11. Introducing Students to Darwin via the Voyage of HMS "Beagle" (United States)

    Swab, Janice C.


    I use the diary that Darwin wrote during the voyage of HMS Beagle and recent images of a few of the places he visited to illustrate some comparisons between Darwin's world and ours. For today's students, increasingly committed to environmental issues, this may be an especially promising way to introduce Darwin.

  12. La ofensiva hacia las tierras comunales indígenas.


    Bonnet Vélez, Diana


    El artículo se concentra en el estudio de las luchas de poder ejercida por algunos actores sociales, especialmente curas, corregidores, "vecinos" y hacendados en relación con la reforma de las tierras comunales indígenas en la segunda mitad del siglo XVIII. La investigación ofrece un panorama general de la actuación de cada uno de estos sujetos sociales, especificando en cada caso el impacto causado en el proceso de reducción de tierras de resguardo y en la conformación de una nueva organizac...

  13. Design of canals

    CERN Document Server

    Swamee, P K


    The book presents firsthand material from the authors on design of hydraulic canals. The book discusses elements of design based on principles of hydraulic flow through canals. It covers optimization of design based on usage requirements and economic constraints. The book includes explicit design equations and design procedures along with design examples for varied cases. With its comprehensive coverage of the principles of hydraulic canal design, this book will prove useful to students, researchers, and practicing engineers. End-of-chapter pedagogical elements make it ideal for use in graduate courses on hydraulic structures offered by most civil engineering departments across the world.

  14. Building networks and servers using BeagleBone

    CERN Document Server

    Pretty, Bill


    If you are a developer with BeagleBone experience and want to learn how to use it to set up a network and file server, then this book is ideal for you. To make the most of this book, you should be comfortable with the Linux operating system and know how to install software from the Internet, but you do not have to be a network guru.

  15. Identification and in vitro derivation of spermatogonia in beagle testis.

    Directory of Open Access Journals (Sweden)

    Kyung Hoon Lee

    Full Text Available BACKGROUND: In vitro culture of spermatogonial stem cells (SSCs is important for exploration of SSCs self-renewal, differentiation, and manipulation. There are several reports on rodent SSC cultures; however, data on SSC cultures in domestic animals are limited. To provide basic scientific information on canine SSC cultures, we report canine testes development, and the development of spermatogonia-derived colonies (SDCs for in vitro cultures. METHODOLOGY/PRINCIPAL FINDINGS: Testes from 2-, 3-, and 12-month-old beagles were used for histology, immunohistochemistry, in vitro culture, immunocytochemistry, and PCR. Protein gene product 9.5 (PGP9.5-positive spermatogonia, both single and paired, were found to be abundant in the testes of 2-month-old beagles. stempro-34 and Dulbecco's modified Eagle medium with 5% fetal bovine serum provided as useful substrates for culture of SDCs, and fibroblast growth factor (FGF played a key role in colony formation. Colonies were positive for alkaline phosphatase and anti-PGP9.5 staining. The early spermatogonia and stem cell markers such as octamer binding protein 4 (Oct4, Nanog homeobox (Nanog, promyelocytic leukemia zinc finger (PLZF, PGP9.5, and GDNF family receptor alpha-1 (GFRα-1 were expressed in the colonies at higher levels than in the testis tissue. CONCLUSIONS: Testes of the 2-month-old beagles had abundant single and paired spermatogonia, which can be used for derivation of SDCs, and FGF was important for colony formation.

  16. Atlas of experimentally-induced neoplasia in beagle dogs

    Energy Technology Data Exchange (ETDEWEB)

    Dagle, G.E.; Watson, C.R.


    Beagle dogs have been utilized extensively in biomedical research. The US Department of Energy`s (DOE) Office of Health and Environmental Research (OHER) has sponsored life-span dose-effect radiation studies in beagles at various laboratories. Because results from studies in the various laboratories were to be compared, all the investigators strove to use similar nomenclature and criteria to describe biological effects. For this reason, pathologists from these laboratories met on five occasions between 1976 and 1977 to discuss nomenclature and histologic criteria for diagnoses. At these meeting, criteria were discussed for histopathologic description of lesions in bone, liver, lung, hematopoietic and lymphoid tissues, mammary gland, pituitary, testis, and thyroid. To provide further assurance of cooperation among the DOE laboratories involved, DOE organized several Task Groups in 1985, composed of staff members from the laboratories. The Task Group on Biological Effects was asked to standardize nomenclature and diagnostic criteria for pathology; this beagle pathology atlas is the result of that request. The atlas describes target organs of particular interest: lungs for radionuclides delivered by inhalation; bones for bone-seeking radionuclides; and hematopoietic and other soft tissues for external irradiation.

  17. Bone Regeneration of Hydroxyapatite/Alumina Bilayered Scaffold with 3 mm Passage-Like Medullary Canal in Canine Tibia Model

    Directory of Open Access Journals (Sweden)

    Jong Min Kim


    Full Text Available The aim of this study was to evaluate the bone regeneration of hydroxyapatite (HA/alumina bilayered scaffold with a 3 mm passage-like medullary canal in a beagle tibia model. A porous HA/alumina scaffold was fabricated using a polymeric template-coating technique. HA/alumina scaffold dimensions were 10 mm in outer diameter, 20 mm in length, and with either a 3 mm passage or no passage. A 20 mm segmental defect was induced using an oscillating saw through the diaphysis of the beagle tibia. The defects of six beagles were filled with HA/alumina bilayered scaffolds with a 3 mm passage or without. The segmental defect was fixated using one bone plate and six screws. Bone regeneration within the HA/alumina scaffolds was observed at eight weeks after implantation. The evaluation of bone regeneration within the scaffolds after implantation in a beagle tibia was performed using radiography, computerized tomography (CT, micro-CT, and fluorescence microscopy. New bone successfully formed in the tibia defects treated with 3 mm passage HA/alumina scaffolds compared to without-passage HA/alumina scaffolds. It was concluded that the HA/alumina bilayered scaffold with 3 mm passage-like medullary canal was instrumental in inducing host-scaffold engraftment of the defect as well as distributing the newly formed bone throughout the scaffold at 8 weeks after implantation.

  18. Estado, mercado de tierra urbana e inundaciones en ciudades argentinas

    Directory of Open Access Journals (Sweden)

    Clichevsky Nora


    Full Text Available En este trabajo se presentan los resultados de una investigación sobre las relaciones que se establecen entre los mercados de tierra urbana y las inundaciones en ciudades argentinas, en el marco más amplio de la vulnerabilidad urbana. Se pretende despejar incógnitas acerca del papel jugado por el Estado como regulador del mercado en áreas urbanas con vulnerabilidad natural a la inundación y como constructor de defensas contra las inundaciones y acerca de los impactos que han tenido las inundaciones y las obras de defensa contra ellas sobre el mercado de tierra y, por lo tanto, sobre el acceso al suelo urbano por parte de los distintos sectores de la población.

  19. Saber tradicional, ética de la tierra y sustentabilidad

    Directory of Open Access Journals (Sweden)

    Heyd, Thomas


    Full Text Available This is the crucial moment to take on sustainable forms of life, and hence it is now of primary importance to adopt a land ethic that takes into account not only the use value but also the intrinsic value of the beings that make up our natural environment. In this essay I begin by focusing on the obstacles that the development of a land ethic has to face, obstacles that are due to limitations in knowledge and to mistaken assumptions. As a way to resolve these practical difficulties I first point out the existence of our natural inclinations toward the land and life. Furthermore, I propose that the traditional knowledge of those peoples that have lived for extended periods with their environments can serve us as models for the development of a culture of appreciation for the earth and its inhabitants.

    Éste ese! momento crucial para emprender formas de vida sustentables, por lo que resulta esencial adoptar una ética de la tierra que reconozca el valor intrínseco además del valor útil de los seres que pueblan nuestro medio ambiente natural. En este ensayo empiezo enfocando los obstáculos a que se enfrenta el desarrollo de una ética de la tierra, obstáculos que resultan ser el producto de conocimientos limitados y suposiciones equivocadas. En resolución de esas problemáticas prácticas apunto, primero, la existencia de inclinaciones naturales hacia la tierra y la vida. Además propongo que en el saber tradicional de los pueblos que han convivido mucho tiempo con sus espacios tenemos modelos de formas del conocer que nos pueden servir de modelo para llegar a desarrollar una cultura de aprecio de la tierra y de sus habitantes.

  20. Las tierras públicas en la Lex Ursonensis

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    Pedro SÁEZ


    Full Text Available RESUMEN: En esta contribución se hace un recorrido por las tierras públicas de las comunidades, incidiendo especialmente en la colonia de Urso, aunque recurriendo en bastantes casos a otras legislaciones municipales. Teniendo en cuenta que estas tierras ya existían en comunidades que no tenían un estatuto jvirídico romano, analizamos las formas de gestión de esos agri vectigales. Dicha gestión comienza por la delimitación exacta de las tierras para proceder a continuación al arrendamiento de las mismas, con las condiciones que la misma ley colonial establece. Finalmente se analiza su evolución histórica.ABSTRACT: In this paper I make a review about the public lands of the communities, especially in the colony of Urso, though appealing in many cases to other muni-, cipal laws. Taking into account that these lands already were existing in communities that did not have a Roman legal statute, I analyze the ways of management of those agri vectigales.This management begins with the precise delimiting of the lands to proceed below to the lease of them, with the conditions establishes by the proper colonial law. Finally the historical evolution of these lands is analyzed.

  1. Identification of the Beagle 2 lander on Mars (United States)

    Bridges, J. C.; Clemmet, J.; Croon, M.; Sims, M. R.; Pullan, D.; Muller, J.-P.; Tao, Y.; Xiong, S.; Putri, A. R.; Parker, T.; Turner, S. M. R.; Pillinger, J. M.


    The 2003 Beagle 2 Mars lander has been identified in Isidis Planitia at 90.43° E, 11.53° N, close to the predicted target of 90.50° E, 11.53° N. Beagle 2 was an exobiology lander designed to look for isotopic and compositional signs of life on Mars, as part of the European Space Agency Mars Express (MEX) mission. The 2004 recalculation of the original landing ellipse from a 3-sigma major axis from 174 km to 57 km, and the acquisition of Mars Reconnaissance Orbiter High Resolution Imaging Science Experiment (HiRISE) imagery at 30 cm per pixel across the target region, led to the initial identification of the lander in 2014. Following this, more HiRISE images, giving a total of 15, including red and blue-green colours, were obtained over the area of interest and searched, which allowed sub-pixel imaging using super high-resolution techniques. The size (approx. 1.5 m), distinctive multilobed shape, high reflectivity relative to the local terrain, specular reflections, and location close to the centre of the planned landing ellipse led to the identification of the Beagle 2 lander. The shape of the imaged lander, although to some extent masked by the specular reflections in the various images, is consistent with deployment of the lander lid and then some or all solar panels. Failure to fully deploy the panels-which may have been caused by damage during landing-would have prohibited communication between the lander and MEX and commencement of science operations. This implies that the main part of the entry, descent and landing sequence, the ejection from MEX, atmospheric entry and parachute deployment, and landing worked as planned with perhaps only the final full panel deployment failing.

  2. Clinical disorders observed in a beagle breeding colony. (United States)

    Fukuda, S; Iida, H; Oghiso, Y; Matsuoka, O


    Disorders in a beagle breeding colony were discussed, based on 472 clinical charts made in 1974-1983. In 201 neonates less than a week old, hypothermia associated with pneumonia was mostly seen. In 31 puppies from one week to two months old and in 46 young dogs from two months to a year old, pneumonia, canine parvovirus infection, dermal abscess and dermatosis were mostly found. In 91 dogs aged from one to five, trauma, intervertebral disc protrusion, dermal abscess, dystocia, claudication and otohematoma were frequently noted. In 103 animals over five years old, intervertebral disc protrusion, tumors, abscess, trauma and otohematoma were observed most often.

  3. Abundance and diversity of Mollusca in the Beagle Channel

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    Katrin Linse


    Full Text Available The malacofauna of the Beagle Channel caught by an epibenthic sledge during the Joint Magellan Victor Hensen Campaign in 1994 was investigated. At 11 locations 16 samples were taken on a transect through the Channel. Species of Aplacophora, Polyplacophora, Gastropoda, Scaphopoda and Bivalvia were identified and quantified. Their horizontal and vertical distribution was described and possible reasons due to their feeding mode discussed. The exact number of specimens collected was 35,084 yielding 107,208 molluscs/ 1000 m2.

  4. Extending the BEAGLE library to a multi-FPGA platform. (United States)

    Jin, Zheming; Bakos, Jason D


    Maximum Likelihood (ML)-based phylogenetic inference using Felsenstein's pruning algorithm is a standard method for estimating the evolutionary relationships amongst a set of species based on DNA sequence data, and is used in popular applications such as RAxML, PHYLIP, GARLI, BEAST, and MrBayes. The Phylogenetic Likelihood Function (PLF) and its associated scaling and normalization steps comprise the computational kernel for these tools. These computations are data intensive but contain fine grain parallelism that can be exploited by coprocessor architectures such as FPGAs and GPUs. A general purpose API called BEAGLE has recently been developed that includes optimized implementations of Felsenstein's pruning algorithm for various data parallel architectures. In this paper, we extend the BEAGLE API to a multiple Field Programmable Gate Array (FPGA)-based platform called the Convey HC-1. The core calculation of our implementation, which includes both the phylogenetic likelihood function (PLF) and the tree likelihood calculation, has an arithmetic intensity of 130 floating-point operations per 64 bytes of I/O, or 2.03 ops/byte. Its performance can thus be calculated as a function of the host platform's peak memory bandwidth and the implementation's memory efficiency, as 2.03 × peak bandwidth × memory efficiency. Our FPGA-based platform has a peak bandwidth of 76.8 GB/s and our implementation achieves a memory efficiency of approximately 50%, which gives an average throughput of 78 Gflops. This represents a ~40X speedup when compared with BEAGLE's CPU implementation on a dual Xeon 5520 and 3X speedup versus BEAGLE's GPU implementation on a Tesla T10 GPU for very large data sizes. The power consumption is 92 W, yielding a power efficiency of 1.7 Gflops per Watt. The use of data parallel architectures to achieve high performance for likelihood-based phylogenetic inference requires high memory bandwidth and a design methodology that emphasizes high memory

  5. Exploraciones Micológicas en Tierra del Fuego Mycological explorations in Tierra del Fuego

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    Irma J. Gamundí


    Full Text Available Se narran las expediciones marítimas y terrestres en Tierra del Fuego durante los siglos XIX y XX, desde el punto de vista de la exploración micológica cuyos resultados han sido vertidos en publicaciones, destacando las expediciones argentinas. Contiene mapas con las principales expediciones argentinas. Se hace una evaluación de la diversidad fúngica de acuerdo con los datos previamente analizados, comparando los registros de colección en ambos períodos que indican una duplicación del número total de taxones de 647 especies descriptas en el siglo XIX hasta 1269 en el siglo XX. Simultáneamente se observa una disminución del 50,4 % al 19.7 % en el número de especies nuevas publicadas. Se agrega una lista de coleccionistas y otra del estado de conservación ex situ de especies seleccionadas. Se hace un breve comentario sobre la conservación de hábitats colonizados por hongos que están perturbados por la explotación no sustentable de los recursos naturales.A narration of the leading maritime and terrestrial expeditions in Fuegia during the XIX and XX centuries is approached from the point of view of the mycological exploration and published results on the mycobiota, emphazising the Argentine expeditions. Maps with the itinerary of main Argentine expeditions is given. An evaluation of the fungal diversity according to the previous review is presented, comparing the fungal records during both periods that shows duplication of the total number of taxa from 647 species described in XIX century to 1269 in the XX century. Simultaneously there is a decrease from 50.4 % to 19.7 % in the number of new species published. A list of collectors and a table with the state of ex-situ conservation of selected species is presented. A brief comment is given on conservation of habitats supporting fungal population that are disturbed by unsustainable exploitation of natural resources.

  6. Bilateral bifid mandibular canal

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    Mahnaz Sheikhi


    Full Text Available One of the normal interesting variations that we may encounter in the mandible is bifid mandibular canal. This condition can lead to difficulties when performing mandibular anesthesia or during extraction of lower third molar, placement of implants, and surgery in the mandible. Therefore diagnosis of this variation is sometimes very important and necessary.

  7. Sulfur dioxide-induced chronic bronchitis in beagle dogs. (United States)

    Greene, S A; Wolff, R K; Hahn, F F; Henderson, R F; Mauderly, J L; Lundgren, D L


    This study was done to produce a model of chronic bronchitis. Twelve beagle dogs were exposed to 500 ppm sulfur dioxide (SO2) for 2 h/d, 5 d/wk for 21 wk and 4 dogs were sham-exposed to filtered ambient air for the same period. Exposure effects were evaluated by periodically examining the dogs using chest radiographs, pulmonary function, tracheal mucous clearance; and the cellular and soluble components of bronchopulmonary lavage fluids. Dogs were serially sacrificed after 13 and 21 wk of exposure and after 6 and 14 wk of recovery. Clinical signs produced in the SO2-exposed dogs included mucoid nasal discharge, productive cough, moist rales on auscultation, tonsilitis, and conjunctivitis. Chest radiographs revealed mild peribronchiolar thickening. Histopathology, tracheal mucous clearance measurements, and lavage cytology were consistent with a diagnosis of chronic bronchitis. It is concluded that repeated exposure to 500 ppm SO2 for 21 wk produced chronic bronchitis in the beagle dog. Complete recovery occurred within 5 wk following cessation of SO2 exposure.

  8. Sulfur dioxide-induced chronic bronchitis in beagle dogs

    Energy Technology Data Exchange (ETDEWEB)

    Greene, S.A.; Wolff, R.K.; Hahn, F.F.; Henderson, R.F.; Mauderly, J.L.; Lundgren, D.L.


    This study was done to produce a model of chronic bronchitis. Twelve beagle dogs were exposed to 500 ppm sulfur dioxide (SO/sub 2/) for 2 h/d, 5d/wk for 21 wk and 4 dogs were sham-exposed to filtered ambient air for the same period. Exposure effects were evaluated by periodically examining the dogs using chest radiographs, pulmonary function, tracheal mucous clearance, and the cellular and soluble components of bronchopulmonary lavage fluids. Dogs were serially sacrificed after 13 and 21 wk of exposure and after 6 and 14 wk of recovery. Clinical signs produced in the SO/sub 2/-exposed dogs included mucoid nasal discharge, productive cough, moist rales on auscultation, tonsilitis, and conjunctivitis. Chest radiographs revealed mild peribronchiolar thickening. Histopathology, tracheal mucous clearance measurements, and lavage cytology were consistent with a diagnosis of chronic bronchitis. It is concluded that repeated exposure to 500 ppm SO/sub 2/ for 21 wk produced chronic bronchitis in the beagle dog. Complete recovery occurred within 5 wk following cessation of SO/sub 2/ exposure. 43 references, 2 figures, 2 tables.

  9. Cardiac conotruncal malformations in a family of beagle dogs. (United States)

    Diez-Prieto, I; García-Rodríguez, B; Ríos-Granja, A; Cano-Rábano, M; Peña-Penabad, M; García, C Pérez


    To study forms of congenital heart disease present in a family of beagle dogs with a strong prevalence of ventricular septal defect and to document the pathological findings associated with the ventricular septal defects and investigate the mode of transmission. The animals were investigated by physical examination, radiography, electrocardiography and ultrasonography to diagnose the presence of congenital heart disease. Some animals were diagnosed at post-mortem examination and the dead animals underwent post-mortem examination to verify the presence of ventricular septal defect. An analysis of pedigree was undertaken and two of the affected animals were mated to investigate the mode of transmission. Among the 28 dogs evaluated clinically or by post-mortem examination, 14 cases of ventricular septal defect were identified. The post-mortem examination showed some abnormalities of the ventricular outflow region associated with malformation of conotruncal septum development. When two affected dogs were bred, congenital heart disease was present in all of the offspring. The congenital heart disease identified in this beagle family can be classified as conotruncal malformation, and an autosomal recessive mode of inheritance was suggested by pedigree analysis.

  10. Construcción con tierra en el siglo XXI

    Directory of Open Access Journals (Sweden)

    Bestraten, S.


    Full Text Available Earthen construction during the 21rst century first decade has resurfaced worldwide as a sustainable, low environmental impact and great expressive material. The research and the number of projects has been increased related to the growth of the associations, institutions, universities and events surrounding this sector. These projects have managed to modernize the traditional techniques of building with earth in order to adapt them to today’s projecting needs, and have been widely recognized for its quality. The aim of this article is to provide a global view on earth construction internationally, providing technical data of its utilization in contemporary architectural projects.

    La construcción con tierra durante la primera década del siglo XXI ha resurgido en todo el mundo como un material con propiedades sostenibles, de bajo impacto ambiental y de gran capacidad expresiva. Se ha experimentado un crecimiento a nivel de proyectos e investigaciones sobre el material relacionado con el aumento de número de asociaciones, instituciones, universidades y eventos alrededor de este sector. Los proyectos actuales han sabido modernizar las técnicas tradicionales de construcción con tierra para adaptarlas a las necesidades proyectuales y constructivas, siendo ampliamente reconocidos por su calidad. El objetivo de este artículo es ofrecer una visión actual sobre la construcción con tierra a nivel internacional, aportando datos técnicos de su utilización en proyectos arquitectónicos contemporáneos.

  11. Sol, Tierra y Luna. Movimientos relativos y sus consecuencias

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    Sebastián Cardenete García


    Full Text Available Cuando se pregunta a los estudiantes por la causa de las estaciones suelen responder: "en verano estamos más próximos al Sol y en invierno estamos más lejos del Sol". La persistencia de esta idea y el hecho de su generalización entre los estudiantes y muchos adultos me ha inducido a escribir este artículo, en el cual se trata de explicar, de una forma clara y simple, el motivo de este y otros fenómenos debidos al movimiento de la Luna alrededor de la Tierra y de ésta alrededor del Sol.

  12. The Beagle 2 Effect - public response to the UK Mars lander (United States)

    Pillinger, J. M.; Pillinger, C. T.

    As a prerequisite for understanding science, the target audience must first be aware of an issue and then continue to maintain interest. We discuss the impact of the Beagle 2 mission to Mars on raising awareness amongst the general public as the first step to increasing understanding of the scientific and technological challenges and solutions such a mission addresses. The massive amount of public interest created is now being ttributed to the so-called "Beagle 2 Effect". We consider the reasons why the public, particularly, but not exclusively, in the UK took Beagle 2 to heart. Initially our strategy, as part of the PR plan for Beagle 2, was to collate media coverage for various stages and discrete campaigns in particular to use press cuttings to determine the level of recognition of Beagle 2 as a brand. At the start of the project this information was to support sponsorship bids, latterly the intrinsic value of media, and hence public, awareness was recognised by the major partners in the project. Much of the subsequent public awareness resulted from the comprehensive coverage in all branches of the media. A second opportunity to evaluate the response to the mission was presented to us as it became increasingly clear that Beagle 2 was able to engage an audience much wider than that typically interested in space, or science in general. We highlighted how far mention of Beagle 2 has spread. Additionally numerous unsolicited letters have been received from the public and these have been collated to indicate the factors which appear to have contributed to the widespread interest in Beagle 2. It is not clear whether the "Beagle 2 Effect" can, or will, be transferred to subsequent space missions.

  13. Managing curved canals

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    Iram Ansari


    Full Text Available Dilaceration is the result of a developmental anomaly in which there has been an abrupt change in the axial inclination between the crown and the root of a tooth. Dilaceration can be seen in both the permanent and deciduous dentitions, and is more commonly found in posterior teeth and in maxilla. Periapical radiographs are the most appropriate way to diagnose the presence of root dilacerations. The controlled regularly tapered preparation of the curved canals is the ultimate challenge in endodontics. Careful and meticulous technique will yield a safe and sufficient enlargement of the curved canals. This article gives a review of the literature and three interesting case reports of root dilacerations.

  14. 1904 : rebelión en la Tierra de Campos

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    Jesús-Ángel Redondo Cardeñoso


    Full Text Available En este trabajo intentamos explicar el porqué de la oleada de huelgas agrícolas que tuvo lugar en Castilla durante el año 1904, y para ello, nos centraremos en el estudio de lo acontecido en la comarca castellano-leonesa de Tierra de Campos, centro neurálgico de la conflictividad que protagonizó el campesino castellano durante ese año. La investigación se basa en el estudio, aparte de la usada Memoria de Adolfo A. Buylla, de la prensa provincial y documentación militar y judicial.In this paper, we try to explain the reason for the spate of farming strikes, that it took place in Castile during the 1904, and for it, we focus our research in the region of Old Castile called Tierra de Campos, that it was the principal area of the disputes were led by the Castilian peasant during that year. The research is based on the study, besides of the trite Memoria of Adolfo A. Buylla, the provincial press and the military and judicial papers.

  15. Observaciones conductuales en el viaje de Darwin abordo del Beagle

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    Segura Alejandro


    Full Text Available Si bien la obra de Darwin ha sido analizada en detalle por historiadores de la ciencia, el papel de la conducta en el desarrollo de la teoría de la evolución no ha sido suficientemente abordado en este tipo de estudios. En este estudio se extraen, describen y analizan las observaciones de comportamiento realizadas por Darwin en El viaje del Beagle. Se presenta el contexto del viajey se describe la ruta, objetivos y características del mismo. Se lleva a cabo una clasificación de los diferentes tipos de observación y los diferentes tipos de comportamiento de múltiplesespecies presentadas por Darwin

  16. Subchronic feeding study in beagle dogs of N-methylpyrrolidone. (United States)

    Becci, P J; Gephart, L A; Koschier, F J; Johnson, W D; Burnette, L W


    The potential toxicity of N-methylpyrrolidone was evaluated following dietary administration for 13 weeks to male and female beagle dogs at dosage levels of 25, 79 and 250 mg per kg body weight per day. Body weight gain and food consumption, hematological and clinical chemical data, and ophthalmic, gross and histopathological examinations were used to study possible toxicological or pathological effects. No statistically significant treatment-related effects that were judged to be biologically meaningful were seen in any parameters of either male or female animals exposed to N-methylpyrrolidone at any dose level. However, a dose-dependent decrease in body weight and increase in platelet count that correlated with increased megakaryocytes was observed. Serum cholesterol in males decreased with increasing doses.

  17. Electron imaging of calcium oxalate crystals in beagle dogs’ urine

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    Walaa I. Mohamaden


    Full Text Available Calcium oxalate crystalluria appears to be a common problem in most of small animal clinics. This current study aimed at inducing a condition of oxalate crystalluria in beagles and record the primary changes in canine blood and urine on response to oxalates injection. 15 dogs were divided into two groups; those in the treatment group were injected intravenously with 0.5 M potassium oxalate and the dogs of control group were injected with physiological saline for five successive days. Urine test revealed a significant decrease in urinary creatinine and urinary urea nitrogen levels. The ultrastructural examination of urine sediment showed typical and atypical phases of calcium oxalate crystals and the X-ray defractionation of these crystals showed high content of calcium in addition to other minerals. Therefore potassium oxalate injection may provide an example of calcium oxalate crystalluria which may answer some question around the pathogenesis of this problem in dogs.

  18. Familial influence on plaque formation in the beagle brain. (United States)

    Russell, M J; White, R; Patel, E; Markesbery, W R; Watson, C R; Geddes, J W


    Aged canines exhibit central neuropathological changes strikingly similar to those seen in patients with Alzheimer's disease. In this study, brain tissue from pure bred beagles raised in a controlled environment were examined for Alzheimer-like pathology. The mean age of the animals was 15.6 years. The incidence of plaques among these 29 dogs was 65.5%. Of the 19 samples that demonstrated Alzheimer-like pathology, 18 were characterized as diffuse and one as neuritic. Plaque density was found to be independent of age. Plaque numbers were highest in the perirhinal cortex and the adjacent temporal cortex. Familial influence on plaque development is supported by congruence within 15 of the 16 litters examined (p < 0.001). In this environmentally controlled group the diffuse plaques were rarely converted to the dense neuritic plaques found in Alzheimer's disease.

  19. Americium in the beagle dog: biokinetic and dosimetric model. (United States)

    Luciani, A; Polig, E; Lloyd, R D; Miller, S C


    A biokinetic model of the systemic distribution of americium in the beagle dog is presented. The model is based on a previous biokinetic model of plutonium. The data sets used for the development of the model were the measurements of excreted activity (urine and feces) and organ burdens (skeleton, liver, and other soft tissues) for different levels of initial injected activity. In developing the model, the compartmental structure of the skeleton of the plutonium model was adopted, and only the numerical values of parameters were adapted. The model well describes the fractions of americium in the skeleton, liver, and soft tissues and the total fraction excreted in urine and feces. The tuning of the liver clearance parameter provides a realistic description of the change in the partitioning between liver and skeleton for different injection levels. The most significant features of the biokinetics and dosimetry of americium and plutonium in beagles are compared. The total fractions of the clearance to the skeleton and the liver are roughly equal to the value for plutonium, but the partitioning of americium between these organs is reversed with respect to the partitioning of plutonium. 241Am doses to liver and skeleton are similar to 239Pu doses, owing to some counteracting factors. For the highest injection level, the liver mass is dependent on the time post injection. For the skeletal tissues, the dose to the cortical endosteum by far exceeds the dose to the trabecular endosteum and the red marrow. The model provides the basis for statistical survival analyses and risk estimates.

  20. Canal plane dynamic visual acuity in superior canal dehiscence. (United States)

    Janky, Kristen L; Zuniga, M Geraldine; Ward, Bryan; Carey, John P; Schubert, Michael C


    1) To characterize normal, horizontal active dynamic visual acuity (DVA) and passive canal plane head thrust DVA (htDVA) across ages to establish appropriate control data and 2) to determine whether horizontal active DVA and passive canal plane htDVA are significantly different in individuals with superior canal dehiscence syndrome (SCDS) before and after surgical repair in the acute (within 10 d) and nonacute stage (>6 wk). Prospective study. Tertiary referral center Patients diagnosed with SCDS (n = 32) and healthy control subjects (n = 51). Surgical canal plugging on a subset of patients. Static visual acuity (SVA), active horizontal DVA, and canal plane htDVA. Visual acuity (SVA, active DVA, and htDVA) declines with age. In SCDS, SVA and active DVA are not significantly affected in individuals after surgical canal plugging; however, htDVA in the plane of the affected canal is significantly worse after canal plugging. Age-based normative data are necessary for DVA testing. In SCDS, htDVA in the plane of the affected canal is normal before surgery but permanently reduced afterward.

  1. Distributed control at Love canal

    Energy Technology Data Exchange (ETDEWEB)

    McPherson, G.; Rider, G.J.; Sadowski, B.; Moore, M.


    Love Canal is known worldwide as the site of one of the worst non-nuclear environmental disasters in modern history. For 12 years, a Niagara Falls, New York chemical company used the canal bed as a chemical dump. This article discusses the computerized control of equipment used to remove the toxic materials from the ground under Love Canal, and how the minimization of maintenance is reducing maintenance costs and increasing operator safety.

  2. Analysis of sedimentation of canals

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    Agunwamba, J.C.,


    Full Text Available The dredged canals in the Niger Delta coastal flood plain are being threatened by siltation. This study is limited to those canals in Rivers State of Nigeria, which are under the influence of tidal waves. A total of eight canals were considered with four each from Ekulama and Cawthorne Channel. Different approaches were used to carry out this study, which includes field reconnaissance survey, hydrographic survey, soil sample analysis and collection of all available data and information. The typical bed materials size (D50 is approximately 0.01mm; which gives a settling velocity of 0.09mm/sec using stroke’s law. Hydrographic survey of the canals from 1992 to 1996 revealed an average siltation rate of 2.35m/yr. A regression equation was also derived which relates the cost of dredging to canal area, rate of siltation and average aggregation. A plot of canal centre profile; entrance, middle and end cross sections showing sediment distribution along the canal profile, shows that majority of the particles that form the sediment enter the canal from the rivers. The sedimentation is caused by the reduction in water current, which has average value of 0.0145m/sec. The bathyorographical check on the canals revealed that the sum of the two exterior angles of the canal with the river at the point of connection has to lie within 1800 + 50 for an effective flow that will minimize settlement of particles. In addition, the canals should be constructed to start and terminate on a moving water body, to avoid dead ends. A regression equation was determined which relates the cost of dredging to canal area, rate of siltation and average aggradations.

  3. Magnetic fabric and microstructures across the Andes of Tierra del Fuego, Argentina Fábrica Magnética y Microestructuras a través de los Andes de Tierra del Fuego, Argentina

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    Federico Esteban


    Full Text Available An anisotropy of magnetic susceptibility (AMS transect was carried out across the Fuegian Andes, in Argentina, withthe aim of studying its tectonic evolution. Two-hundred and forty oriented samples were collected from 27 sites distributed between the Paso Garibaldi to the north and the Canal Beagle to the south. The study was restricted to the Upper Jurassic Lemaire Formation, with a single site located in the Lower Cretaceous Yahgán Formation. Stu-died rocks comprised basaltic, andesitic, volcaniclastic and sedimentary rocks affected by low-grade metamorphism. AMS measurements were complemented with thin section analyses of representative samples in order to characterize the microstructures and metamorphic assemblages. In general, the magnetic fabric shows dominantoblate shapes and a large variation in the anisotropy degree from 1.04 up to 2. The anomalously high values were observed to be associa-ted to growth of secondary pyrrhotite, which was identified by rock magnetic tests. Magnetic foliation was generally consistent with slaty cleaveage as observed in the field, confirming the tectonic origin of the magnetic fabric. Three geographic domains were distinguished in the study región on the basis of the pattern of the AMS axes distribution. In the northern domain, from Paso Garibaldi to Valle Carbajal, the orientation of the máximum susceptibility axis (κ1, or magnetic lineation, is N-S to NE-SW with modérate plunge towards the S-SW and coincides with previous determination of mineral lineations associated with the Andean deformation and very low grade metamorphism. The magnetic fabric pattern can be correlated with the main deformational phase responsible for the development of slaty cleavage (main Andean deformational phase and the tectonic transport due to progression of the Fuegian fold and thrust belt in the Late Cretaceous. A different character is shown along the Valle Carbajal domain, where subvertical E-W magnetic foliation

  4. Tierras comestibles de la Cuenca del Titicaca: Geofagia en la prehistoria boliviana


    David L. Browman


    El presente artículo resume la evidencia que existe sobre el uso que se le da a 24 tipos de tierras por los pobladores de los Andes Centrales, ya sea como complemento alimenticio o como medicina. Las muestras analizadas provienen de contextos arqueológicos y de muestras adquiridas en los mercados locales. Las tierras incluyen un grupo de filosilicatos, otro grupo se compone de tierras sódicas y de calcio, otro de minerales de azufre, y el último corresponde a un grupo compuesto por hierro y s...

  5. Lumbar canal stenosis. (United States)

    Mazanec, D J; Drucker, Y; Segal, A M


    Lumbar canal stenosis is an increasingly recognized condition in patients more than 65 years of age. The clinical syndrome is dominated by neurogenic claudication. The natural history of the Condition is not yet well described. Long-term results of surgical therapy are frequently disappointing, and reoperation is required in more than 10% of patients. Nonoperative treatment options include physical therapy exercise programs, calcitonin, analgesics, and epidural steroid injections. A clinical pathway for management of symptomatic stenosis, emphasizing an initial nonoperative approach, is suggested.

  6. Spinal canal stenosis; Spinalkanalstenose

    Energy Technology Data Exchange (ETDEWEB)

    Papanagiotou, P.; Boutchakova, M. [Klinikum Bremen-Mitte/Bremen-Ost, Klinik fuer Diagnostische und Interventionelle Neuroradiologie, Bremen (Germany)


    Spinal stenosis is a narrowing of the spinal canal by a combination of bone and soft tissues, which can lead to mechanical compression of spinal nerve roots or the dural sac. The lumbal spinal compression of these nerve roots can be symptomatic, resulting in weakness, reflex alterations, gait disturbances, bowel or bladder dysfunction, motor and sensory changes, radicular pain or atypical leg pain and neurogenic claudication. The anatomical presence of spinal canal stenosis is confirmed radiologically with computerized tomography, myelography or magnetic resonance imaging and play a decisive role in optimal patient-oriented therapy decision-making. (orig.) [German] Die Spinalkanalstenose ist eine umschriebene, knoechern-ligamentaer bedingte Einengung des Spinalkanals, die zur Kompression der Nervenwurzeln oder des Duralsacks fuehren kann. Die lumbale Spinalkanalstenose manifestiert sich klinisch als Komplex aus Rueckenschmerzen sowie sensiblen und motorischen neurologischen Ausfaellen, die in der Regel belastungsabhaengig sind (Claudicatio spinalis). Die bildgebende Diagnostik mittels Magnetresonanztomographie, Computertomographie und Myelographie spielt eine entscheidende Rolle bei der optimalen patientenbezogenen Therapieentscheidung. (orig.)

  7. Complete atrioventricular canal

    Directory of Open Access Journals (Sweden)

    Limongelli Giuseppe


    Full Text Available Abstract Complete atrioventricular canal (CAVC, also referred to as complete atrioventricular septal defect, is characterised by an ostium primum atrial septal defect, a common atrioventricular valve and a variable deficiency of the ventricular septum inflow. CAVC is an uncommon congenital heart disease, accounting for about 3% of cardiac malformations. Atrioventricular canal occurs in two out of every 10,000 live births. Both sexes are equally affected and a striking association with Down syndrome was found. Depending on the morphology of the superior leaflet of the common atrioventricular valve, 3 types of CAVC have been delineated (type A, B and C, according to Rastelli's classification. CAVC results in a significant interatrial and interventricular systemic-to-pulmonary shunt, thus inducing right ventricular pressure and volume overload and pulmonary hypertension. It becomes symptomatic in infancy due to congestive heart failure and failure to thrive. Diagnosis of CAVC might be suspected from electrocardiographic and chest X-ray findings. Echocardiography confirms it and gives anatomical details. Over time, pulmonary hypertension becomes irreversible, thus precluding the surgical therapy. This is the reason why cardiac catheterisation is not mandatory in infants (less than 6 months but is indicated in older patients if irreversible pulmonary hypertension is suspected. Medical treatment (digitalis, diuretics, vasodilators plays a role only as a bridge toward surgery, usually performed between the 3rd and 6th month of life.

  8. Hypertonic Saline Dextran Ameliorates Organ Damage in Beagle Hemorrhagic Shock.

    Directory of Open Access Journals (Sweden)

    Jing-xiang Zhao

    Full Text Available The goal of this study was to investigate the effect of hypertonic saline with 6% Dextran-70 (HSD resuscitation on organ damage and the resuscitation efficiency of the combination of HSD and lactated ringers (LR in a model of hemorrhage shock in dogs.Beagles were bled to hold their mean arterial pressure (MAP at 50 ± 5 mmHg for 1 h. After hemorrhage, beagles were divided into three groups (n = 7 to receive pre-hospital resuscitation for 1 h (R1: HSD (4 ml/kg, LR (40 ml/kg, and HSD+LR (a combination of 4 ml/kg HSD and 40 ml/kg LR. Next, LR was transfused into all groups as in-hospital resuscitation (R2. After two hours of observation (R3, autologous blood was transfused. Hemodynamic responses and systemic oxygenation were measured at predetermined phases. Three days after resuscitation, the animals were sacrificed and tissues including kidney, lung, liver and intestinal were obtained for pathological analysis.Although the initial resuscitation with HSD was shown to be faster than LR with regard to an ascending MAP, the HSD group showed a similar hemodynamic performance compared to the LR group throughout the experiment. Compared with the LR group, the systemic oxygenation performance in the HSD group was similar but showed a lower venous-to-arterial CO2 gradient (Pv-aCO2 at R3 (p < 0.05. Additionally, the histology score of the kidneys, lungs and liver were significantly lower in the HSD group than in the LR group (p < 0.05. The HSD+LR group showed a superior hemodynamic response but higher extravascular lung water (EVLW and lower arterial oxygen tension (PaO2 than the other groups (p < 0.05. The HSD+LR group showed a marginally improved systemic oxygenation performance and lower histology score than other groups.Resuscitation after hemorrhagic shock with a bolus of HSD showed a similar hemodynamic response compared with LR at ten times the volume of HSD, but HSD showed superior efficacy in organ protection. Our findings suggest that


    National Research Council Canada - National Science Library

    Edwin Paky; Fabián Moreno; Esteban Álvarez-Dávila


    .... En este estudio se reporta elcontenido de carbono en un bosque de tierra firme del resguardoVillazul-Nonuya RVN de la Amazonia colombiana, con base en una parcelapermanente de 6 ha. Se evalúa...

  10. Pharmacokinetics of BMEDA after Intravenous Administration in Beagle Dogs

    Directory of Open Access Journals (Sweden)

    Chih-Hsien Chang


    Full Text Available The pharmacokinetics of N,N-bis(2-mercapatoethly-N',N'-diethylenediamine (BMEDA, a molecule that can form a chelate with rhenium-188 (188Re to produce the 188Re-BMEDA-liposomes, was studied. In this work, beagles received a single injection of BMEDA, at doses of 1, 2, or 5 mg/kg; the concentration of BMEDA in the beagles’ plasma was then analyzed and determined by liquid chromatography-mass spectrometry/mass spectrometry. Based on the pharmacokinetic parameters of BMEDA, we found that male and female animals shared similar patterns indicating that the pharmacokinetics of BMEDA is independent of gender differences. In addition, the pharmacokinetics of BMEDA was seen to be non-linear because the increase of mean AUC0–t and AUC0–∞ values tend to be greater than dose proportional while the mean Vss and CL values of BMEDA appeared to be dose dependent. The information on the pharmacokinetics of BMEDA generated from this study will serve as a basis to design appropriate pharmacology and toxicology studies for future human use.

  11. Biokinetic model of americium in the beagle dog

    Energy Technology Data Exchange (ETDEWEB)

    Luciani, A.; Polig, E.; Lloyd, R. D.; Miller, S. C.


    A biokinetic model of the systemic distribution of americium in the beagle dog is presented. The model is based on a previous biokinetic model of plutonium. The data sets used for the development of the model are the measurements of excreted activity (urine and feces) and organ burdens (skeleton, liver and other soft tissues). In developing the model, the part of the plutonium model representing the skeleton, which was based on histomorphometric and autoradiographic investigations, has not been modified with regard to both its structure (compartments for the trabecular/cortical volume, surface and marrow) and the remodelling rates. Other skeletal parameters such as the transfer rate from marrow to blood and the partitioning of transferred activity from the blood to trabecular/cortical surface and volume were optimized to describe the element-specific biokinetics in the skeleton. The model well describes the fractions of americium in the skeleton, liver and soft tissues and the total fraction excreted in urine and feces. Particularly it demonstrates the possibility of describing the behavior of americium in the skeleton with a model substantially analogous to the model of plutonium in humans. However it differs from the ICRP model of the skeleton with regard to the fundamental structure and the predictive power. This study will be the starting point for a future improvement of the currently used americium model for humans, particularly for the skeleton. (Author) 9 refs.

  12. Hood Canal Steelhead - Hood Canal Steelhead Supplementation Experiment (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Hood Canal Steelhead Project is a 17-year before-after-control-impact experiment that tests the effects of supplementation on natural steelhead populations in...

  13. Recent Deglaciation of Darwin Mountains (Tierra de Fuego) after Little Ice Age: monitoring by photogrammetry, lichenometry, dendrochronology and field studies. (United States)

    García-Sancho, L.; Palacios, D.; Zamorano, J. J.; Green, A.; Vivas, M.; Pintado, A.


    Glaciers from the Darwin mountain range have been retreating since the Little Ice Age (LIA). However, the amount of retreat varies and is minimal for some glacial snouts and substantial for others. Possible explanations for this different behaviour include climatic and glacial dynamic causes. The aim of this work was to analyse the impact of climate change on these glaciers. The research site was the terminus of glacier Pia, which descends to the south of Mount Darwin (2488 m asl, 54°45'S, 69°29'W) and reaches the coastline at the Beagle Channel. The terminus is situated some hundreds of meters above the LIA moraine but, whereas one sector retreated rapidly and then stabilized, another sector has had several advances and retreats leaving a number of moraine arches. To better understand the origin of this dynamic behaviour, we undertook a study of the evolution of the terminus of glacier Pia over the last 60 years. We used aerial photographs and satellite images to determine the exact location of the glacial terminus in certain years (1943, 1963, 1987, 1990, 2001 and 2006). These results were completed in 2008 and 2009 through field work. We also carried out lichenometric studies of the two most abundant lichen species that rapidly colonize the moraine boulders abandoned by the glacier: Placopsis perrugosa and Rhizocarpon geographicum. By comparing results from field work carried out in 2008 and 2009, we were able to determine the growth rate of these two species (García-Sancho et al. 2011). In addition, we also carried out a dendrochronological study of Nothofagus antarctica and N. betuloides. The use of the four techniques involved in this study (photogrammetry, lichenometry, dendrochronology and multiyear field work) allowed us to establish the ecesis period of each species as well as their growth curves, from which we can deduce the movements of the glacial terminus from the end of the LIA to the present. From this study we can infer that the different

  14. Method for Constructing Standardized Simulated Root Canals. (United States)

    Schulz-Bongert, Udo; Weine, Franklin S.


    The construction of visual and manipulative aids, clear resin blocks with root-canal-like spaces, for simulation of root canals is explained. Time, materials, and techniques are discussed. The method allows for comparison of canals, creation of any configuration of canals, and easy presentation during instruction. (MSE)

  15. Caracterizacion de los sistemas ganaderos en dos comunidades del municipio de Tuzantla de la region de Tierra Caliente, Michoacan

    National Research Council Canada - National Science Library

    Villa-Mendez, C.I; Tena, M.J; Tzintzun, R; Val, D


    Los sistemas de produccion ganaderos de la region de Tierra Caliente estan vinculados al manejo agrosilvopastoril, aprovechando una amplia gama de recursos forrajeros naturales, siendo las familias...

  16. Quantification of brown dog tick repellents, 2-hexanone and benzaldehyde, and release from tick-resistant beagles, Canis lupus familiaris (United States)

    We have recently shown that repellency of the tick Rhipicephalus sanguineus sensu lato by the tick resistant dog breed Beagle is mediated by volatile organic compounds 2-hexanone and benzaldehyde present in Beagle dog odour. Ectoparasite location on animal hosts is affected by variation in odour com...

  17. Looking back at Love Canal

    Energy Technology Data Exchange (ETDEWEB)

    Deegan, J. Jr.


    In the first part of this series (ES and T, April 1987, pp. 328-31) it was pointed out that the methods and conclusions of EPA's Love Canal Study were the subject of some controversy in the environmental community. Others defended the agency's approaches and methods. Part 2 makes no attempt to resolve the controversy; its purpose is to present the results and conclusions of the Love Canal.

  18. Electroretinography recordings using a light emitting diode active corneal electrode in healthy beagle dogs. (United States)

    Itoh, Yoshiki; Maehara, Seiya; Itoh, Norihiko; Yamashita, Kazuto; Izumisawa, Yasuharu


    Electroretinography (ERG) is a well-established diagnostic procedure for objectively evaluating retinal function. In this study, ERG in beagle dogs, which are a popular experimental animal, was performed to determine the normal range of ERG variables and assess differences between the left and right eyes. ERG findings including rod, combined rod-cone, single-flash cone, and 30-Hz flicker responses were recorded with an LED-electrode in 43 sedated beagle dogs. The subjects were divided into young (dogs. No significant differences were observed between the left and right eyes. ERG variables in beagle dogs differed by age due to age-related retinal changes. Thus, we propose that normal ERG ranges should be determined according to age in each clinic and laboratory using its own equipment because each institution usually has different systems or protocols for ERG testing.

  19. Real-time implementation of logo detection on open source BeagleBoard (United States)

    George, M.; Kehtarnavaz, N.; Estevez, L.


    This paper presents the real-time implementation of our previously developed logo detection and tracking algorithm on the open source BeagleBoard mobile platform. This platform has an OMAP processor that incorporates an ARM Cortex processor. The algorithm combines Scale Invariant Feature Transform (SIFT) with k-means clustering, online color calibration and moment invariants to robustly detect and track logos in video. Various optimization steps that are carried out to allow the real-time execution of the algorithm on BeagleBoard are discussed. The results obtained are compared to the PC real-time implementation results.

  20. El Canal del Atazar I

    Directory of Open Access Journals (Sweden)

    López de Berges y de los Santos, Emilio


    Full Text Available The Atazar Canal helps to supply Madrid with water, from the rivers Lozoya, Jarama and Sorbe. The section which operates at present starts at the Torrelaguna dam and finishes at the El Goloso reservoir. Later a further section will be added, from the Atazar dam, on the Lozoya river, to link up with the control dam at Torrelaguna. The canal capacity is 16 m3/sec, and it is 43.47 km long. It has a slope of 4/10.000. The cross section is similar to that of the Jarama canal, already built. There are interconnections between this canal and the Canal Alto, which previously supplied the high and medium part of Madrid. To overcome the ground unevenness 5 syphons have been built, the most important of which is the Colmenar Goloso syphon, which is 10.88 km in length. Construction commenced on December 10, 1962, and water reached Madrid on June 15th, 1966. The initial budget for this project was 1,500 million pesetas.El canal del Atazar refuerza considerablemente el abastecimiento de aguas a Madrid, procedentes de los ríos Lozoya, Jarama y, en un próximo futuro, del Sorbe. El tramo, actualmente en funcionamiento, empieza en el salto de Torrelaguna y finaliza en los depósitos de El Goloso. Más adelante se completará su trazado mediante un nuevo tramo que partirá del embalse de Atazar, en el Lozoya, para unirse al actual en el depósito regulador de Torrelaguna. Su capacidad es de 16 m3/s; su longitud, 43,471 km, y su pendiente, 4 diezmilésimas. La sección tipo es análoga a la del canal del Jarama, de construcción anterior. Mediante la oportuna obra de transvase se realizan intercambios entre este Canal y el Canal Alto que abastecía anteriormente la parte media y alta de la capital. Para salvar los desniveles del terreno se han construido 5 sifones, siendo el más importante el de Colmenar-Goloso, con una longitud de 10,8S4 km. El comienzo de las obras tuvo lugar el 10 de diciembre de 1962, y el agua llegó a Madrid el 15 de junio de 1966. Su

  1. Epidemiological surveillance of ovine hydatidosis in Tierra del Fuego, Patagonia Argentina, 1997-1999. (United States)

    Zanini, Fabián; Gonzalo, Roberto; Pérez, Héctor; Aparici, Inés; Soto, Ximena; Guerrero, Juvenal; Cerrone, Gloria; Elissondo, Celina


    Cystic echinococcosis is the most prevalent zoonosis in Tierra del Fuego province, Argentina, with important economic, productive and public health consequences. The present work was performed to determine the ovine prevalence in Tierra del Fuego, Argentina, as well as to evaluate the quality of diagnostic systems in slaughterhouses. Moreover, genetic analyses to characterize the strain of Echinococcus granulosus involved in the region were done. The first actions to perform a diagnosis of the epidemiological situation of hydatidosis in Tierra del Fuego were done between 1976 and 1977. A canine prevalence of 80% and an ovine prevalence of 55% results were obtained. Since 1979 the control program of Hydatidosis of Tierra del Fuego was implemented. It was based on semiannual canine anthelmintic treatment with praziquantel at dose of 5mg/kg, and complemented with sanitary education and canine and ovine epidemiological surveillance. During May 1997-January 1999: 5,916 sheep coming from 20 farms of the programmatic area were evaluated. In the lamb category, hydatid cysts were not found. In the adults category, 62 infected animals were found (3.2%). The ovine prevalence was 1.1% and there was 100% of coincidence between diagnosis in the slaughterhouse, re-inspection in the laboratory and histopathological study. The marked decrease in the prevalence observed for sheep infection evidenced a destabilization of the biological cycle of the parasite. This could be explained by the application of a control program with uninterrupted systematic actions. Polymerase chain reaction-ribosomal ITS-1 DNA (rDNA) restriction fragment length polymorphism (PCR-RFLP) analysis and partial sequencing of the mitochondrial cytochrome c oxidase subunit 1 (CO1) gene were used to characterize E. granulosus isolates collected from different regions of Tierra del Fuego to determine which genotypes occurred in this region. The results revealed the presence of the G1 genotype (sheep-dog strain

  2. Geología y Ciencias de la Tierra: Etimología y un poco de historia


    Anguita, Francisco


    La Geología, o tratado de la Tierra, y las Ciencias de la Tierra, o conjunto de conocimientos sobre la Tierra, no constituyen campos de conocimiento coincidentes. Es evidente que la Geología es una Ciencia de la Tierra; pero el dato esencial es que la Geología clásica se construyó sobre una tradición geográfica, mientras que las Ciencias de la Tierra están basadas en una síntesis de la tradición naturalista con metodologías propias de las Ciencias Físicas, como la modelización y la cuantifica...

  3. Benthic decapod crustaceans associated with captures of Munida spp. (Decapoda: Anomura in the Beagle Channel, Argentina

    Directory of Open Access Journals (Sweden)

    Patricia Pérez Barros


    Full Text Available Benthic decapod crustacean assemblages in the Beagle Channel are dominated by the galatheid crabs Munidasubrugosa and Munida gregaria. This study deals with the bathymetric and spatial distribution, density and diversity of the assemblage of decapod species that co-occur with Munida spp. in the Beagle Channel. A total of 131 samples were obtained using an epibenthic trawl from February 1999 to December 2000. They were taken monthly from two depth strata separated by the 40 m isobath (range: 4-262 m, and from three different sites: Bahía Lapataia, Ushuaia and Punta Segunda. Sixteen of the 36 recorded species of decapod crustaceans from the Beagle Channel were caught. Munidasubrugosa and M. gregaria contributed 94% to the total decapod material. Of the remaining 6%, Austropandalusgrayi (Caridea was the most abundant species, constituting 43% of the non-galatheid decapod fraction. Some species, namely Paguruscomptus and Eurypodius spp., were characteristic of shallow waters ( 40 m. The average density and diversity of non-galatheid decapods varied with depth and location. Decapod diversity correlated positively with the density of algae and polychaete tubes. The influence of three-dimensional bottom structure on decapod diversity in the Beagle Channel is discussed.

  4. Sphaeromatidae (Crustacea, Isopoda) of the Beagle Channel and description of Cymodopsis beageli n. sp

    NARCIS (Netherlands)

    Brandt, Angelina


    During an expedition with RV Victor Hensen (1994) and the RV Polarstern (1996) Isopoda Sphaeromatidae were collected in and off the eastern entrance of the Beagle Channel. The species found, Caecocassidias patagonica Kussakin, 1967, Cassidinopsis emarginata (Guérin-Méneville, 1843) and Moruloidea

  5. The Voyage of the Beagle: Field Work Lessons from Charles Darwin. (United States)

    Smith, Louis M.


    Analyzes Charles Darwin's letters to his family during his voyage on H.M.S. Beagle. Relates the information to the development of Darwin's professional identity and the degree to which the concepts, field methods, and research methods revealed in Darwin's personal correspondence are useful to students of educational administration. (MD)

  6. Web-Beagle: a web server for the alignment of RNA secondary structures. (United States)

    Mattei, Eugenio; Pietrosanto, Marco; Ferrè, Fabrizio; Helmer-Citterich, Manuela


    Web-Beagle ( is a web server for the pairwise global or local alignment of RNA secondary structures. The server exploits a new encoding for RNA secondary structure and a substitution matrix of RNA structural elements to perform RNA structural alignments. The web server allows the user to compute up to 10 000 alignments in a single run, taking as input sets of RNA sequences and structures or primary sequences alone. In the latter case, the server computes the secondary structure prediction for the RNAs on-the-fly using RNAfold (free energy minimization). The user can also compare a set of input RNAs to one of five pre-compiled RNA datasets including lncRNAs and 3' UTRs. All types of comparison produce in output the pairwise alignments along with structural similarity and statistical significance measures for each resulting alignment. A graphical color-coded representation of the alignments allows the user to easily identify structural similarities between RNAs. Web-Beagle can be used for finding structurally related regions in two or more RNAs, for the identification of homologous regions or for functional annotation. Benchmark tests show that Web-Beagle has lower computational complexity, running time and better performances than other available methods. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  7. Elimination Half-Lives of Acute Phase Proteins in Rats and Beagle Dogs During Acute Inflammation. (United States)

    Kuribayashi, Takashi; Seita, Tetsuro; Momotani, Eiichi; Yamazaki, Shunsuke; Hagimori, Kohei; Yamamoto, Shizuo


    The half-lives of typical acute phase proteins in rats and beagle dogs during acute inflammation were investigated. Acute inflammation was induced by injection of turpentine oil in rats and administration of indomethacin in beagle dogs. Serum concentrations of α2-macroglobulin (α2M) and C-reactive protein (CRP) were measured by enzyme-linked immunosorbent assay and α1-acid glycoprotein (AAG) was measured by single radial immunodiffusion. Half-life was calculated as 0.693/elimination rate constant (K). The mean half-lives in the terminal elimination phase of α2M and AAG were 68.1 and 164.8 h, respectively. The half-life of AAG was significantly longer than that of α2M. Mean half-lives in the terminal elimination phase of CRP and AAG were 161.9 and 304.4 h, respectively. The half-life of AAG was significantly longer than that of CRP in beagle dogs. No significant differences in the half-life of AAG were observed between rats and beagle dogs. Furthermore, serum concentrations in the terminal elimination phase could be simulated with the K data acquired in this study.

  8. Arquitectura de tierra -histórica y moderna- en Italia


    Galdieri, Eugenio


    El trabajo de carácter histórico sobre las construcciones con tierra en Italia, tanto de adobe como de tapial presenta una panorámica de las zonas geográficas en las que se encuentran enclavadas, así como el tipo de usos y posibles orígenes históricos, entre los que el autor señala los fuertes vínculos con las construcciones de tierra españolas, tanto en Cagliaria (influencia aragonesa) como en Oristano (influencia castellana).

  9. Desarrollo de un nuevo ladrillo de tierra cruda, con aglomerantes y aditivos estructurales de base vegetal


    Amorós García, Marta


    En base al estudio realizado por las universidades de Sevilla y Glasgow sobre ladrillos de tierra cruda, lana y algas (Construction and Building Materials, Volume 24, Issue 8, August 2010, Pages 1462-1468), se pretende trabajar en el desarrollo de un nuevo ladrillo de tierra cruda, no tóxico y ecológico, al cual se le incorporarán residuos no valorizables de origen vegetal, disponibles en España, que aporten funciones aglomerantes y estructurales. En este caso, se utilizará el alga Gelidium s...

  10. Ab interno Schlemm's Canal Surgery. (United States)

    Francis, Brian A; Akil, Handan; Bert, Benjamin B


    In primary open-angle glaucoma, the site of greatest resistance to aqueous outflow is thought to be the trabecular meshwork (TM) and inner wall of Schlemm's canal. Augmentation of the conventional (trabecular) outflow pathway can facilitate physiologic outflow and subsequently lower intraocular pressure. The most recent approach to enhancing the conventional outflow pathway is via an internal approach to the TM and Schlemm's canal. Ab interno Schlemm's canal surgery includes 4 novel surgical approaches: (1) removal of the TM and inner wall of Schlemm's canal by an internal approach (ab interno trabeculectomy), (2) implantation of a microstent to bypass the TM, (3) disruption of the TM and inner wall of Schlemm's canal via an internal approach (ab interno trabeculotomy), and (4) dilation of Schlemm's canal via an internal approach (ab interno canaloplasty). The first category includes the Trabectome (Neomedix, Tustin, CA, USA), and Kahook Dual Blade (New World Medical, Rancho Cucamonga, CA, USA). The second category includes the iStent (Glaukos, Laguna Hills, CA, USA), as well as the investigational Hydrus Microstent implant (Ivantis, Irvine, CA, USA). The third category includes gonioscopic-assisted transluminal trabeculotomy (iSciences catheter; Ellex, Adelaide, Australia), and 360° suture trabeculotomy (TRAB360, Sight Sciences, Menlo Park, CA, USA). The fourth category includes ab interno canaloplasty or AbiC (Ellex), and Visco360 (Sight Sciences). In contrast to external filtration surgeries, such as trabeculectomy and aqueous tube shunt, these procedures are categorized as internal filtration surgeries and are performed from an internal approach via gonioscopic guidance. Published results suggest that these surgical procedures are both safe and efficacious for the treatment of open-angle glaucoma. © 2017 S. Karger AG, Basel.

  11. Developmental spinal canal stenosis and somatotype.


    Nightingale, S.


    The hypothesis that somatotype and cervical spine developmental canal stenosis may be associated has been investigated by anthropometry and measurement of lateral projection cervical spine radiographs. A significant association of canal size with somatotype has been found such that those with developmentally narrow canals are more likely to have relatively shorter long-bones, particularly in the upper arm, and longer trunks.

  12. Erie Canal Technology: Stump Pullers (United States)

    Greenslade, Thomas B., Jr.


    Many years ago I saw a picture of a huge set of wheels that was used to remove tree stumps during the construction of the Erie Canal (1817-1825) and was intrigued by its use of leverage, mechanical advantage, and torque. Figure 1 is a scale model of the device based on my memory of the (lost) picture and published accounts.

  13. Contemporary root canal filling strategies

    NARCIS (Netherlands)

    Moinzadeh, A.T.


    Currently, clinicians can choose from a wide range of root canal filling materials and techniques, some of which have been evaluated in this thesis. Methacrylate resin-based sealers suffer from polymerization shrinkage stresses. This limitation may partly be overcome by a two-step cementation

  14. Retention of Root Canal Posts

    DEFF Research Database (Denmark)

    Sahafi, A; Benetti, Ana Raquel; Flury, S


    ] and a self-etch adhesive resin cement [Panavia F2.0]) were used. After removal of the crowns of 360 extracted premolars, canines, or incisors, the root canals were prepared with a parallel-sided drill system to three different final diameters. Half the posts did not receive any pretreatment. The other half...

  15. Campesinos contra campesinos: conflictos agrarios y lucha por la tierra en Comoapan, Veracruz (1925-1942

    Directory of Open Access Journals (Sweden)

    Rogelio Jiménez Marce


    Full Text Available El objetivo del trabajo es mostrar las gestiones que los campesinos de Comoapan, Veracruz, una congregación dependiente en ese momento de San Andrés Tuxtla, hicieron ante las autoridades agrarias para tratar de que les dotara de las fértiles tierras que se dedicaban al cultivo del tabaco, situación que generó un enfrentamiento contra la familia Carrión, misma que era una de las principales productoras de la hoja en la región de los Tuxtlas. Para conservar sus tierras, los Carrión apoyaron la formación de una agrupación campesina, conformada por sus peones y campesinos que no tenían derecho a obtener tierra ejidal, y que se convirtió en antagonista de la que pedía las tierras. Se busca entender los complejos procesos que se vivieron en Comoapan y las interrelaciones que se establecieron entre ejidatarios y no ejidatarios, a fin de mostrar que el reparto agrario no constituyó un proceso carente de problemáticas.


    Directory of Open Access Journals (Sweden)

    Alberto Hernández Jiménez


    Full Text Available El cambio de uso de la tierra, sobre todo el cambio de tierras forestales a tierras cultivadas, es una de las prácticas que mayor impacto ha tenido en la degradación de los suelos en el mundo y que ha provocado, en gran parte, la emisión de CO2 a la atmósfera. Por esto se hace necesario evaluar los cambios que han tenido las propiedades de los suelos por los diferentes ecosistemas, para de esta forma, tomar las medidas de mejoramiento y conservación de los suelos. En este trabajo, se estudia por primera vez, el cambio de algunas propiedades de los suelos de las partes medias y bajas de la microcuenca Membrillo (provincia de Manabí, Ecuador. Esta microcuenca presenta un relieve alomado, premontañoso, en la cual predominan bosques primarios y secundarios y plantaciones de cacao, pastizales y cultivos como el maíz en su parte baja. Los suelos son Feozems, Cambisoles y Fluvisoles y se presentan los resultados sobre cambios en sus características morfológicas (color, tipo de estructura, espesor de los horizontes A y B, las pérdidas de carbono orgánico y el cambio en la densidad aparente del suelo, provocado por el cambio de uso de la tierra.

  17. Los Takanas: el acceso a la tierra y los recursos naturales (1950-2003.

    Directory of Open Access Journals (Sweden)

    Zulema Lehm Ardaya


    uso comercial de diferentes especies naturales. El artículo discute la adaptación de los takanas a los desafíos y tendencias del uso de los recursos naturales en sistemas de acceso comunitario a la tierra.

  18. Un congreso de fisica estudia la composicion de las capas de la tierra

    CERN Multimedia


    "El Congreso de Internacional de Neutrinos, que ayer comenzo en el Jardin Botanico de Valencia, aborda, entre otros aspectos, la composicion y el perfil tomografico de las distintas capas de estratos del interior de la Tierra, segun informo a Efe el profesor Jose Furtado Valle" (1/2 page).

  19. La Carta de la Tierra en educación obligatoria desde una perspectiva internacional

    Directory of Open Access Journals (Sweden)

    Eva Francisca Hinojosa-Pareja


    Full Text Available La Carta de la Tierra surge como iniciativa de la sociedad civil en el año 2000. Desde su comienzo, es avalada por instituciones y organizaciones internacionales como la Unesco, que apoyó su contenido en 2003, e incorporada como instrumento educativo en proyectos de aplicación internacional como la “Década de la Educación para el Desarrollo Sostenible (2005-2014”, promovida por Naciones Unidas. Este artículo analiza distintas experiencias internacionales que utilizan la Carta de la Tierra como elemento de innovación en el ámbito de la educación obligatoria (infantil, primaria y secundaria. Una década después de la publicación de la Carta de la Tierra, y a través del análisis del contenido de estas experiencias, pretendemos hacer balance del camino recorrido, del grado de compromiso asumido desde el ámbito educativo, y favorecer el diálogo y la progresiva toma de conciencia sobre la Carta de la Tierra y su relevancia a nivel educativo.

  20. Medidas de resistividad de terrenos e impedancias de puesta a tierra


    Castellanos Domínguez, César Germán


    Este libro consta de ocho capítulos: Resistividad del suelo, Medida de impedancia de puesta a tierra, Aspectos prácticos de medidas, Características de los elementos de medición, Seguridad y precauciones en medidas, Potenciales y gradientes, Efectos fisiológicos de la corriente eléctrica e Intensidades de falla.

  1. «Huarpes no tan huarpes» y «hombres modernos»: interpelaciones étnicas y disputas por las últimas tierras irrigadas en Mendoza (Argentina

    Directory of Open Access Journals (Sweden)

    Leticia Saldi


    Full Text Available A través de un estudio etnográfico en la periferia del oasis de riego más importante del centro-oeste argentino, se analiza la intervención de persistentes representaciones étnico-raciales y ambientales en la delimitación de áreas irrigadas y de grupos sociales que ostentan la tenencia del agua y la tierra. Los grupos situados a uno y otro lado de los últimos canales de riego son interpelados desde paradigmas modernistas que vinculan a la tenencia del agua, la propiedad privada y la producción vitivinícola con la herencia europea y la idea de progreso, mientras que lo no irrigado, la tenencia comunitaria de la tierra y el pastoreo trashumante se asocia a la descendencia indígena huarpe y a la idea de atraso o involución. Debido a la presencia de dos espacios y grupos socio-culturales supuestamente autónomos, opuestos y separados por los últimos canales de riego es que se los conceptualiza como frontera hídrica. Esta, a pesar de ser considerada como natural y fija, es por el contrario artificial y dinámica, producto de luchas sociales y simbólicas por el agua y por la obtención de legitimidad como grupo socio-cultural capaz de obtenerla y controlarla. Asimismo se resaltan la presencia no solo de actores liminales, ni huarpes ni de origen europeo, sino también de alianzas que pueden llevar a la reconfiguración de espacios irrigados y de grupos socioculturales capaces de dar batalla en las disputas por los recursos naturales.

  2. Mandibular Second Premolar with Four Canals

    Directory of Open Access Journals (Sweden)

    Javad Ghiasi


    Full Text Available A mandibular second premolar with four canals is an interesting example of anatomic variations. This report describes a case of a mandibular second premolar with three roots and four canals (one mesiobuccal, two distobuccal and one lingual. The canals were prepared using K-files and irrigated with NaOCl (5.25% and normal saline as the final irrigant. The canals were filled laterally with gutta percha and AH26 sealer (De Trey, Dentsply, Switzerland. This case shows a rare anatomic configuration and points out the importance of looking for additional canals.

  3. 75 FR 39632 - Regulated Navigation Area; Gulf Intracoastal Waterway, Inner Harbor Navigation Canal, Harvey... (United States)


    ..., Inner Harbor Navigation Canal, Harvey Canal, Algiers Canal, New Orleans, LA; Correction ACTION: Interim... Navigation Canal, Harvey Canal, Algiers Canal, New Orleans, LA into the Code of Federal Regulations. That...

  4. Spontaneous and bilateral necrosis of the femoral head in a young experimental beagle dog. (United States)

    Kobayashi, Ryosuke; Kurotaki, Tetsuro; Yamada, Naoaki; Kumabe, Shino; Doi, Takuya; Wako, Yumi; Tsuchitani, Minoru


    This report describes the pathological characterizations of a rare case of necrosis of the femoral head that was spontaneous, bilateral, avascular and nontraumatic. A 14-month-old beagle dog was presented with pain in the hind limbs. At necropsy, the articular surface in the bilateral femoral head was markedly irregular. There were no gross abnormalities other than in the hip joints. Microscopically, a wide range of trabecular bone necrosis localized in the subchondral area was observed in both femoral heads. In the right femoral head, fibrosis and proliferative vessels were noted in the subchondral area. The articular cartilage was thickened irregularly, but there was no evidence of cartilage necrosis. The bone marrow adjacent to the affected area showed severe depression. In the metaphysis, atrophic bone marrow, but not bone necrosis, was observed. This was a rare case of spontaneous necrosis of the femoral head in an experimental beagle dog.

  5. Effects of Acupuncture on Heart Rate Variability in Beagles; Preliminary Results

    Directory of Open Access Journals (Sweden)

    Huan Wang


    Full Text Available Evidence-based animal experimental research concerning the effects of acupuncture on autonomic function was performed by two research teams from China and Austria. This study describes measurements in beagles. Heart rate variability (HRV recordings were performed under stable conditions in Beijing, China, and the data analysis and interpretation were completed in Graz, Austria. The electrocardiograms were recorded during bilateral body acupuncture (PC6, Neiguan. Power of the low frequency (LF, high frequency (HF, and the ratio (LF/HF changed significantly during acupuncture stimulation in beagles after injection of atropine and β-blocker. However, there was no significant change in HF power after needling the Neiguan acupoint when a cervical vagotomy has been performed. Our findings show that acupuncture can mediate the HRV even after pharmaceutical blocking of autonomic function. Acupuncture effects on HRV should rely not only on autonomic nervous system but on complete central nervous system.

  6. Digenea in notothenioid fish in the Beagle Channel (Magellanic sub-region, sub-Antarctica). (United States)

    Jeżewski, Witold; Zdzitowiecki, Krzysztof; Laskowski, Zdzisław


    Fish of five species of Notothenioidei (104 specimens), Cottoperca trigloides, Patagonotothen brevicauda, P. longipes, P. tessellata and Champsocephalus esox, caught in the Beagle Channel (Magellanic sub-region, sub-Antarctica) were infected with Digenea of nine species (1130 specimens). Faunistic data on the occurrence of all nine parasites are provided. The most abundant digenean species was Macvicaria magellanica found in the intestine of three host species of the genus Patagonotothen. The second most abundant digenean species was Elytrophalloides oatesi found in the stomach of four host species, with exception of P. brevicauda. Three digenean species: Stenakron kerguelense, Whitegonimus ozoufae and Genolinea bowersi, were more abundant in fish caught at the harbor of Ushuaia (depth 7-9 m), remaining six species: M. magellanica, Neolepidapedoides subantarcticus, Postmonorchis variabilis, Derogenes varicus, E. oatesi and Lecithaster macrocotyle, in the eastern mouth of the Beagle Channel (depth 30 m).

  7. How Do You Answer the Life on Mars Question? Use Multiple Small Landers Like Beagle 2 (United States)

    Gibson, Everett K.; Pillinger, C. T.; Wright, I. P.; Hurst, S. J.; Richter, L.; Sims, M. R.


    To address one of the most important questions in planetary science Is there life on Mars? The scientific community must turn to less costly means of exploring the surface of the Red Planet. The United Kingdom's Beagle 2 Mars lander concept was a small meter-size lander with a scientific payload constituting a large proportion of the flown mass designed to supply answers to the question about life on Mars. A possible reason why Beagle 2 did not send any data was that it was a one-off attempt to land. As Steve Squyres said at the time: "It's difficult to land on Mars - if you want to succeed you have to send two of everything".

  8. The shallow-water Asellota (Crustacea: Isopoda from the Beagle Channel: Preliminary taxonomic and zoogeographical results

    Directory of Open Access Journals (Sweden)

    Brenda Lía Doti


    Full Text Available The shallow-water Asellota from the Beagle Channel were investigated, based on material collected at four localities in 2001-2002. A total of 3,124 asellotes were sorted, and three new species and 12 new records of distribution were reported. The Paramunnidae showed the highest species diversity and abundance (11 species and 1,463 specimens. The present research raises the number of species known from the Beagle Channel to 23; of these, 16 were previously reported from the Magellan Straits, representing 69% of similarity. Based on the present results and published data, the faunistic affinities for the shallow-water Asellota was 30% between the Magellan region and the Scotia Arc, and 26% between the Magellan region and the Antarctic Peninsula.

  9. Quantitation of uveoscleral outflow in normotensive and glaucomatous Beagles by /sup 3/H-labeled dextran

    Energy Technology Data Exchange (ETDEWEB)

    Barrie, K.P.; Gum, G.G.; Samuelson, D.A.; Gelatt, K.N.


    In uveoscleral outflow, aqueous humor leaves the anterior chamber and passes caudally through the trabecular meshwork and the sclerociliary cleft to enter the supraciliary and suprachoroidal spaces. The fluid is then absorbed by choroidal and scleral circulations. Using /sup 3/H-labeled dextran, uveoscleral outflow was quantitated in normotensive and glaucomatous Beagles under general anesthesia. The intrascleral plexus was isolated and /sup 3/H-labeled dextran was injected into the anterior chamber. Intrascleral plexus contents were sampled every 5 minutes over a 30- to 60-minute period. The eyes were enucleated, sectioned, and prepared for scintillation counting. Uveoscleral outflow accounted for 15% and 3% of the total aqueous humor outflow in the normotensive dogs and in the advanced glaucomatous dogs, respectively. In the advanced glaucomatous Beagle, conventional and uveoscleral outflow pathways were reduced and contributed to the etiopathogenesis of glaucoma.

  10. Serum alkaline phosphatase isoenzymes in laboratory beagle dogs detected by polyacrylamide-gel disk electrophoresis. (United States)

    Hatayama, Kazuhisa; Nishihara, Yoshito; Kimura, Sayaka; Goto, Ken; Nakamura, Daichi; Wakita, Atsushi; Urasoko, Yoshinaka


    Serum alkaline phosphatase (ALP) activity is frequently measured in toxicity studies. Itoh et al. (2002) reported that a commercially available polyacrylamide-gel (PAG) disk electrophoresis kit used in humans (AlkPhor System, Jokoh Co., Ltd., Tokyo, Japan) for identifying serum ALP isoenzymes was useful for veterinary clinicopathological diagnosis in mongrel dogs. In the present study, based on the report of Itoh et al. (2002), we tried to expand the application range of this kit to laboratory beagle dogs which are commonly used in toxicity studies. In order to identify the origin of each ALP isoenzyme, tissue ALP extracts from the liver, bone and small intestine and serum samples were treated with neuraminidase, anti-small intestinal ALP antibody, ALP inhibitor levamisole and/or wheat germ agglutinin (WGA). The main serum ALP isoenzymes in 5-month-old intact beagle dogs were bone-derived (bone and atypical ALP: corresponding to human variant bone ALP) and they tended to decrease with age. However, liver-derived ALP isoenzyme greatly increased in the serum of cholestasis model dogs. The cholestasis model dogs also had a large molecular ALP detected in the resolving gel. This ALP could be originated from intestinal ALP or corticosteroid-induced ALP (CALP), because the activity remained even after levamisole inhibition. CALP was observed in intact laboratory beagle dogs with individual differences. These results suggest that the present method is a useful tool for detecting serum ALP isoenzymes in laboratory beagle dogs and concomitant levamisole inhibition with another gel is applicable for the evaluation of organ toxicity.

  11. Meiofauna communities from the Straits of Magellan and the Beagle Channel

    Directory of Open Access Journals (Sweden)

    G. C. Chen


    Full Text Available Meiofauna from 20 stations (ranging between 8 and 550 m in the Magellan Straits and the Beagle Channel revealed 28 small sized taxa of higher categories including the temporary meiofauna. Nematoda, Copepoda Harpacticoidea and Polychaeta occurred in all samples; Turbellaria, Bivalvia, Kinorhyncha and Ostracoda were regularly present. Nematodes represented between 68% and 94% of the meiofauna at each station, followed by the copepods (2.3% to 14.5% and polychaetes (1.1% to 11.5%. Maximal total density, 9700 individuals 10 cm-2, was found in the surroundings of Picton Island, while the mean abundance per station was 3374 individuals 10 cm-2. The vertical pattern within the sediment showed that 87% of meiofauna components concentrated in the upper 0-5 cm sediment layers and 13% in the lower ( > 5cm layers. More than 95% of copepods, as well as the temporary meiofauna occurred in the top 5 cm layers. The proportion of nematodes and copepods shows opposite trends in the vertical distribution. Multivariate analysis using the total density and the 10 `true´ meiofauna taxa densities discriminates between communities in the Straits of Magellan and the Beagle Channel area. Meiofaunal density was much higher in the Beagle Channel, but the diversity was lower than that in the Straits of Magellan. The Southern Magellan meiofauna communities are compared with those found at the Antarctic Peninsula and in the Weddell Sea (high Antarctic. It is considered that hydrodynamic features (tidal currents with strong winds, geographical characteristics, together with sediment composition are the key parameters structuring the meiofauna community in the Straits of Magellan and in the Beagle Channel.

  12. Pharmacokinetics of Ginkgolide B after Oral Administration of Three Different Ginkgolide B Formulations in Beagle Dogs

    Directory of Open Access Journals (Sweden)

    Jie Zhao


    Full Text Available Ginkgolide B (GB, an important active constituent of Ginkgo biloba extract, has been used in clinical applications for the treatment of dementia, cerebral insufficiency or related cognitive decline. To investigate the main pharmacokinetic characteristics of three different GB formulations in beagle dogs, a simple, specific and sensitive LC-MS/MS method was established and validated. The separation of the analytes was achieved on an Agilent Eclipse Plus C18 column (1.8 μm, 2.1 × 50 mm with a mobile phase consisting of water and acetonitrile. The flow rate was set at 0.4 mL/min. Quantitation was performed using multiple reaction monitoring (MRM in negative ion mode, with the transitions at m/z (Q1/Q3 423.1/367.1 for GB and m/z 269.3/170.0 for IS. The linear calibration curve of GB was obtained over the concentration range of 2–200 ng/mL. The intra- and inter-day precisions were <15% and the accuracies were within ±12.7%. The validated method was applied to compare the pharmacokinetic characteristics of GB in healthy beagle dogs after oral administration of three formulations (HME08, GB capsule prepared by hot-melt extrusion technology; LL06, GB pellet prepared by liquid layer technology; conventional GB tablet. The Cmax values of GB from different formulations in beagle dog plasma were 309.2, 192.4 and 66.6 µg/L, and the AUC values were 606.7, 419.1 and 236.2 µg/L·h, respectively. The data suggested that the exposure level of GB from HME08 and LL06 in beagle dog plasma was greatly improved compared with conventional tablets. This study should be helpful for the design and development of oral GB preparations.

  13. Mural folliculitis and alopecia with cutaneous candidiasis in a beagle dog. (United States)

    Lee, Hyun-A; Hong, Sunhwa; Choe, Ohmok; Kim, Okjin


    A one-year-old male Beagle dog showed dermatitis, alopecia and scales. Examination of the affected dog revealed generalized alopecia, patchy erythema, and superficial erosions with histological evidence of mural folliculitis. External tests for parasites in scraped skin samples were negative. However, fungal culture tests and polymerase chain reaction revealed the existence of Candida in the lesion. These results suggest that cutaneous candidiasis may induce mural folliculitis and alopecia in dogs.

  14. Mural Folliculitis and Alopecia with Cutaneous Candidiasis in a Beagle Dog


    LEE, HYUN-A; Hong, SunHwa; Choe, Ohmok; Kim, Okjin


    A one-year-old male Beagle dog showed dermatitis, alopecia and scales. Examination of the affected dog revealed generalized alopecia, patchy erythema, and superficial erosions with histological evidence of mural folliculitis. External tests for parasites in scraped skin samples were negative. However, fungal culture tests and polymerase chain reaction revealed the existence of Candida in the lesion. These results suggest that cutaneous candidiasis may induce mural folliculitis and alopecia in...

  15. [Tomography of the pterygoid canals]. (United States)

    Riazantsev, S V; Kalenov, V E; Russkikh, N A


    This paper presents an X-ray scheme for calculating the depth of pterygoid canals required for accurate tomography. The scheme includes three lines: line A corresponds to the physiological horizontal line, line B is drawn, normally to line A through the tip of the nose, and line C is the perpendicular from line B to the upper third of the posterior wall of the pterygopalatine fossa. The length of line B plus 1 cm (thickness of external nose soft tissues) is the value to be determined. Twenty-six patients underwent X-ray examinations by an EDK-750B unit (70 kV, 150 mA, 1.65 s). In all cases 1-3 images were sufficient to obtain good visualization of the pterygoid canals.

  16. Scalloping at the lumbosacral canal

    Energy Technology Data Exchange (ETDEWEB)

    Reinhardt, R.


    Scalloping is an indentation of the dorsal side of the vertebral body (anterior wall of the lumbosacral or sacral canal) which typically involves several adjacent lumbal vertebral body segments and the anterior wall of the canalis sacralis. Occurrence without underlying disease is rare; it occurs most frequently with chondrodystrophy, neurofibromatosis, Morquio's syndrome, Hurler's syndrome, acromegaly, Ehlers-Danlos syndrome, Marfan's syndrome, cysts, tumors and in peridural lipomas.

  17. Endometriosis en el canal inguinal


    Quirós, José Luis; Corrales, Daniela


    Resumen: Endometriosis se define como la presencia de tejido glandular y estromal endometrial fuera de la cavidad uterina y este tejido ectópico es dependiente de la estimulación estrogénica. Usualmente se presenta en ovarios, fondos de saco, ligamento ancho, ligamento uterosacro, útero, trompas de Falopio, tracto gastrointestinal y geniturinario. Sin embargo, puede presentarse en otras localizaciones, como en el canal inguinal. Prevalece en 10% de las mujeres en edad reproductiva. Existen mu...

  18. SNPs of melanocortin 4 receptor (MC4R) associated with body weight in Beagle dogs. (United States)

    Zeng, Ruixia; Zhang, Yibo; Du, Peng


    Melanocortin 4 receptor (MC4R), which is associated with inherited human obesity, is involoved in food intake and body weight of mammals. To study the relationships between MC4R gene polymorphism and body weight in Beagle dogs, we detected and compared the nucleotide sequence of the whole coding region and 3'- and 5'- flanking regions of the dog MC4R gene (1214 bp). In 120 Beagle dogs, two SNPs (A420C, C895T) were identified and their relation with body weight was analyzed with RFLP-PCR method. The results showed that the SNP at A420C was significantly associated with canine body weight trait when it changed amino acid 101 of the MC4R protein from asparagine to threonine, while canine body weight variations were significant in female dogs when MC4R nonsense mutation at C895T. It suggested that the two SNPs might affect the MC4R gene's function which was relative to body weight in Beagle dogs. Therefore, MC4R was a candidate gene for selecting different size dogs with the MC4R SNPs (A420C, C895T) being potentially valuable as a genetic marker.

  19. Charles Darwin's beagle voyage, fossil vertebrate succession, and "the gradual birth & death of species". (United States)

    Brinkman, Paul D


    The prevailing view among historians of science holds that Charles Darwin became a convinced transmutationist only in the early spring of 1837, after his Beagle collections had been examined by expert British naturalists. With respect to the fossil vertebrate evidence, some historians believe that Darwin was incapable of seeing or understanding the transmutationist implications of his specimens without the help of Richard Owen. There is ample evidence, however, that he clearly recognized the similarities between several of the fossil vertebrates he collected and some of the extant fauna of South America before he returned to Britain. These comparisons, recorded in his correspondence, his diary and his notebooks during the voyage, were instances of a phenomenon that he later called the "law of the succession of types." Moreover, on the Beagle, he was following a geological research agenda outlined in the second volume of Charles Lyell's Principles of Geology, which implies that paleontological data alone could provide an insight into the laws which govern the appearance of new species. Since Darwin claims in On the Origin of Species that fossil vertebrate succession was one of the key lines of evidence that led him to question the fixity of species, it seems certain that he was seriously contemplating transmutation during the Beagle voyage. If so, historians of science need to reconsider both the role of Britain's expert naturalists and the importance of the fossil vertebrate evidence in the development of Darwin's ideas on transmutation.

  20. Multilocus genotypes from Charles Darwin's finches: biodiversity lost since the voyage of the Beagle. (United States)

    Petren, Kenneth; Grant, Peter R; Grant, B Rosemary; Clack, Andrew A; Lescano, Ninnia V


    Genetic analysis of museum specimens offers a direct window into a past that can predate the loss of extinct forms. We genotyped 18 Galápagos finches collected by Charles Darwin and companions during the voyage of the Beagle in 1835, and 22 specimens collected in 1901. Our goals were to determine if significant genetic diversity has been lost since the Beagle voyage and to determine the genetic source of specimens for which the collection locale was not recorded. Using 'ancient' DNA techniques, we quantified variation at 14 autosomal microsatellite loci. Assignment tests showed several museum specimens genetically matched recently field-sampled birds from their island of origin. Some were misclassified or were difficult to classify. Darwin's exceptionally large ground finches (Geospiza magnirostris) from Floreana and San Cristóbal were genetically distinct from several other currently existing populations. Sharp-beaked ground finches (Geospiza difficilis) from Floreana and Isabela were also genetically distinct. These four populations are currently extinct, yet they were more genetically distinct from congeners than many other species of Darwin's finches are from each other. We conclude that a significant amount of the finch biodiversity observed and collected by Darwin has been lost since the voyage of the Beagle.

  1. In vivo ocular imaging of the cornea of the normal female laboratory beagle using confocal microscopy. (United States)

    Strom, Ann R; Cortés, Dennis E; Thomasy, Sara M; Kass, Philip H; Mannis, Mark J; Murphy, Christopher J


    To obtain normative data for the normal laboratory beagle cornea using high-resolution in vivo confocal microscopy (IVCM). Sixteen eyes of eight healthy young female intact beagles. The central cornea was imaged using IVCM. Mixed effects linear regression was used for statistical analysis. in vivo confocal microscopy allowed detailed visualization and quantification of epithelial cells (superficial epithelial cell diameter: 43.25 ± 6.64 μm, basal cell diameter: 4.43 ± 0.67 μm), and nerve fibers (subepithelial nerve fiber diameter: 2.38 ± 0.69 μm, anterior stromal nerve fiber diameter: 16.93 ± 4.55 μm). Keratocyte density (anterior stroma 993.38 ± 134.24 cells/mm(2) , posterior stroma 789.38 ± 87.13 cells/mm(2) ) and endothelial cell density (2815.18 ± 212.59 cells/mm(2) ) were also measured. High-resolution IVCM provides detailed noninvasive evaluation of the cornea in the normal laboratory beagle. © 2015 American College of Veterinary Ophthalmologists.

  2. Microbiology of normal external auditory canal. (United States)

    Stroman, D W; Roland, P S; Dohar, J; Burt, W


    To isolate and characterize bacteria and fungi from the healthy ear and to obtain susceptibility profiles on each bacterial isolate. Prospective. Specimens were collected from the external canals and cerumen of healthy subjects. Species-level identification was obtained by combining phenotypic and genotypic data. End-point minimal inhibitory concentration testing was performed using National Committee for Clinical Laboratory Standards recommended methods. One hundred sixty-four subjects were cultured. Seventeen canal and 16 cerumen specimens showed no growth. One hundred forty-eight cerumen specimens yielded 314 organisms, including 23 fungi. One hundred forty-seven canal specimens yielded 310 organisms, including 7 fungi. Of 291 bacteria isolated from cerumen, 99% were Gram-positive. Of 302 bacteria isolated from the canal, 96% were Gram-positive. Staphylococci were 63% of both the cerumen bacteria and the canal bacteria. Coryneforms represented 22% of the bacteria in cerumen and 19% in the canal. Turicellaotitidis was the primary coryneform isolated from both the canal and the cerumen. Streptococci-like bacteria were 10% from the cerumen, 7% from the canal. In both cerumen and canal, Alloiococcusotitis was more than 95% of the streptococci-like bacteria. Fifteen gram-negative organisms were isolated from the canal and cerumen, including four Pseudomonas aeruginosa strains. The percentages of Staphylococcus epidermidis isolates that had high-level resistance (> or =8 microg/mL) were as follows: to neomycin, 28% from cerumen and 11% from the canal; to oxacillin, 28% from cerumen and 25% from the canal; and to ofloxacin, 15% from cerumen and 19% from the canal. Turcellaotitidis and A. otitidis were present with a much higher frequency than previously described, lending evidence that they be considered normal otic flora. Corynebacterium auris, previously reported only in children, was isolated from normal adults.

  3. Dispersión-depositación del polen actual en Tierra del Fuego, Argentina Dispersion-depositation of current polen in Tierra del Fuego, Argentina

    Directory of Open Access Journals (Sweden)

    Matilde E. Trivi de Mandri


    Full Text Available La estrecha relación existente entre la vegetación y el polen que ésta produce favorece el estudio de las comunidades vegetales desde un punto de vista palinológico. De esta manera es posible obtener información sobre la distribución de la vegetación por medio de la dispersión y depositación de los granos de polen. La caracterización polínica de las comunidades vegetales permite investigar la historia de la vegetación desde la perspectiva actualista. El objetivo de este trabajo es caracterizar la dispersión-depositación del polen actual en relación con la distribución de la vegetación utilizando análisis estadísticos multivariados (clasificación y correspondencia como un paso esencial para futuros estudios de la historia ambiental del Holoceno de la Isla Grande de Tierra del Fuego. El área de estudio está localizada en el sector argentino de la Isla Grande de Tierra del Fuego a 52°40'S-55°7'S; 65°05'O-68°40'O. El resultado de los métodos numéricos y su asociación con los parámetros ambientales ha permitido la diferenciación de un continuum de comunidades que pertenecen a diferentes unidades fisonómicas: bosque y estepa graminosa.The close relationship existing between vegetation and the pollen it produces favours the study of plant communities from a palynological point of view. Therefore, it is possible to have information about the distribution of vegetation by means of the dispersal and deposition of pollen grains. The pollen characterisation of the vegetation communities allows us to investigate the vegetation history from an actualistic point of view. The aim of this work is to characterise the modern pollen dispersal-deposition in relation to the vegetation distribution by using multivariate statistical analysis (cluster and correspondence analyses as an essential step for future studies on the Holocene environmental history of Isla Grande de Tierra del Fuego. The study area is located in the Argentine

  4. Primeros ensayos petrofísicos sobre la roca dimensional de Tierra del Fuego First petrophysical trials over dimension stones of Tierra del Fuego


    Rogelio Daniel Acevedo; Mauricio González-Guillot


    Se muestran aquí los primeros ensayos de laboratorio sobre las rocas dimensionales de Tierra del Fuego, región que tenía una potencialidad no evaluada respecto al uso posible de este recurso nativo. Nunca habían sido empleadas hasta ahora rocas duras (ígneas) ni pizarras en la construcción residencial, el revestimiento de fachadas ó pisos. Dos pequeñas canteras de rocas plutónicas han sido abiertas recientemente: una de ellas en el cerro Jeu-Jepén, aprovechada para la construcción de la escol...

  5. Visión de la Concentración de la Tierra en América Latina

    NARCIS (Netherlands)

    C. Kay (Cristóbal)


    textabstractEn este breve artículo presento de manera muy general y esquemática algunos aspectos sobre la concentración de la tierra en América Latina. No pretendo hacer un análisis detallado y completo sobre la problemática de la tierra en la región. Pero espero poder resaltar algunos factores que

  6. An experimental approach for archeological soil micromorphology: building a model for site taphonomy in coastal shell middens of the Beagle Channel (Argentina) (United States)

    Balbo, Andrea; Suarez Villagran, Ximena; Madella, Marco; Vila, Asumpcio; Estevez, Jordi


    There are still many archaeological contexts where soil micromorphology has been little applied. Examples of such are anthropic shell deposits, common in coastal settings worldwide. These archaeological sites have complex stratigraphies composed mainly of shell from diverse species of local mollusks and gastropods. They have the peculiarity of being highly porous sediments with a coarse fraction that is dominated by gravel-sized bioclastic remains (shell, fish bones) and a fine fraction composed of organic material (charcoal, organic matter). The use of soil micromorphology in shell deposits was started by the Spanish-Argentinean research team working in Tierra del Fuego (Argentina) since 1986. This project focused on excavation of hunter-gatherer sites from the contact period. One of the main objectives was to develop a detailed excavation method for shell middens that maximized the amount of recorded data during archaeological excavation. In this perspective, microstratigraphy was conceived as a fundamental complement for the study of site formation processes, as it would provide with high definition data for identification of shell accumulation episodes, trampling on site, abandonment periods, taphonomic alterations etc. A reference collection of known environmental and anthropic control features, such as hearths, trampling areas, wood ashes from local species, among others, was built to help in the microscopic characterization of archaeological samples. In this work, we analyze this experimental collection and compare it with samples from the Tunel VII archaeological site, located in the northern coast of the Beagle Channel and dated from the 18th-19th centuries. The set of modern samples included: trampling area from an animal pathway; beach deposit; forest litter; soil under the forest; hearths lit in diverse contexts (on the prairie, the beach and from the archaeologist camp site); and experimental burnt valves of Mytilus edulis, the main malacological

  7. Developmental spinal canal stenosis and somatotype. (United States)

    Nightingale, S


    The hypothesis that somatotype and cervical spine developmental canal stenosis may be associated has been investigated by anthropometry and measurement of lateral projection cervical spine radiographs. A significant association of canal size with somatotype has been found such that those with developmentally narrow canals are more likely to have relatively shorter long-bones, particularly in the upper arm, and longer trunks. Images PMID:2769282

  8. Arquitectura de tierra -histórica y moderna- en Italia

    Directory of Open Access Journals (Sweden)

    Galdieri, Eugenio


    Full Text Available This work about the history of mud constructions in Italy -both of brick and formwork- gives an exposition of geographical zones where those are located, the kind of uses so as their possible historic origins, among which the author points the strong connections with Spanish adobe constructions, both in Cagliars (Aragonese influence and in Oristano (Castilian influence.El trabajo de carácter histórico sobre las construcciones con tierra en Italia, tanto de adobe como de tapial presenta una panorámica de las zonas geográficas en las que se encuentran enclavadas, así como el tipo de usos y posibles orígenes históricos, entre los que el autor señala los fuertes vínculos con las construcciones de tierra españolas, tanto en Cagliaria (influencia aragonesa como en Oristano (influencia castellana.

  9. Desplazamiento forzado y propiedad de la tierra en Antioquia, 1996-2004

    Directory of Open Access Journals (Sweden)

    Carlos Felipe Gaviria


    Full Text Available El desplazamiento forzoso es un fenómeno mundial que ha acompañado crisis políticas y sociales, relacionado, además, con el dominio del territorio por parte de los grupos inmersos en el conflicto. En Colombia, este fenómeno social se ha incrementado en los últimos años, junto con problemas agrarios, sociales y productivos. El objetivo de este artículo es analizar la relación existente entre el desplazamiento forzado y los procesos de concentración de la tierra en Antioquia entre 1996–2004. Se encuentra que existe una relación positiva entre propiedad de la tierra y desplazamiento forzado; en especial en Urabá y Oriente, subregiones antioqueñas con la producción agrícola más importante.

  10. Design of earth network in electric substations; Diseno de redes de tierra en subestaciones electricas

    Energy Technology Data Exchange (ETDEWEB)

    Raull-Martin, J. [Universidad Nacional Autonoma de Mexico, Mexico, D.F. (Mexico)


    The purpose of this paper is to present a summarized version of the different types of construction of grounding systems, as web as their materials and formulas, which are necessary and useful for the design and building of a grounding network for medium to high voltage facilities. A description is also made of how to determine the electrical resistivity of subsoil layers with different physical characteristics. Several illustrative examples are also solved in the paper. [Spanish] El proposito de este articulo es presentar de manera resumida los diferentes tipos de construccion de los sistemas de tierra, asi como sus materiales y formulas, los cuales son necesarios y utiles para el diseno y edificacion de una red de tierra para instalaciones de mediana y alta tension. Se describe tambien la obtencion de las diferentes resistividades que presentan los terrenos con diversas caracteristicas fisicas. Asi mismo, se solucionan ejercicios ilustrativos a lo largo del articulo.

  11. Efecto de la impermeabilidad del Mucílago de Nopal en bloques de tierra comprimidos

    Directory of Open Access Journals (Sweden)

    Yolanda Guadalupe Aranda Jiménez


    Full Text Available La arquitectura de tierra1 es conocida desde hace siglos, sin embargo, actualmente es poco utilizada comparado con los sistemas constructivos comunes. Los bloques de tierra comprimido (BTC son elementos constructivos con un potencial elevado para ser utilizado en las construcciones de vivienda en México, principalmente por su similitud con los bloques tradicionales, siendo conveniente mejorar sus características a partir de un estabilizante. Se realizó el estudio de BTC estabilizados con cemento y una sustancia proveniente de las pencas maduras de nopal. Se encontró que al añadir mucílago de nopal se observa un incremento significativo de la resistencia a la compresión húmeda y seca, lo cual estar relacionado con una disminución de la porosidad; se ofrecen algunas relaciones del efecto del mucílago en el sólido analizado.

  12. Desplazamiento forzado y propiedad de la tierra en Antioquia, 1996-2004

    Directory of Open Access Journals (Sweden)

    Carlos Felipe Gaviria


    Full Text Available El desplazamiento forzoso es un fenómeno mundial que ha acompañado crisis políticas y sociales, relacionado, además, con el dominio del territorio por parte de los grupos inmersos en el conflicto. En Colombia, este fenómeno social se ha incrementado en los últimos años, junto con problemas agrarios, sociales y productivos. El objetivo de este artículo es analizar la relación existente entre el desplazamiento forzado y los procesos de concentración de la tierra en Antioquia entre 1996-2004. Se encuentra que existe una relación positiva entre propiedad de la tierra y desplazamiento forzado; en especial en Urabá y Oriente, subregiones antioqueñas con la producción agrícola más importante.

  13. Development of the anterior chordal canal. (United States)

    Tóth, Miklós; Moser, Gerhard; Patonay, Lajos; Oláh, Imre


    Resent advances have led to the reexamination of the intraosseous pathway of the chorda tympani a few years ago and they stated that the nerve never enters the mandibular fossa and its exit the skull base in the sphenopetrosal fissure. In our report, 58 temporal bones were investigated after maceration and formalin fixation in order to understand the development of the anterior chordal canal. Our study revealed that the chorda tympani leaves the tympanic cavity through the tympanosquamosal fissure before formation of the anterior chordal canal of Huguier. This canal is situated parallel to and in front of the musculotubal canal and formed by the processus inferior tegminis tympani and the sphenoid bone between the second and fifth years of age. Prior to the age of 2, only the exit of the bony canal exists which is gradually followed by the appearance of a groove in the growing processus inferior tegminis tympani. The borders of the groove elevate and develop to upper and lower plates which lengthen with similar plates of the sphenoid bone, completing the anterior chordal canal by the fifth postnatal year. The entrance of the canal develops above the petrotympanic fissure and similar to the canal itself, it is also completely formed in the fifth year. In case of an incomplete development the anterior chordal canal remains partially opened laterally which might allow the head of the mandibula to effect the chorda tympani mechanically causing Costen's syndrome.

  14. Real Cédula de tierras de 1780 (2 de Agosto

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    Historia Social y de la Cultura Anuario Colombiano de


    Full Text Available Tomado del archivo Histórico Nacional (Bogotá. Tierras de Antioquia, T.X,folios 1 r.-21 v. En la transcripción del documento se introdujeron algunas modificaciones en la ortografía y en la puntuación con el fin de hacer  ágil la utilización del texto.

  15. Seguimiento de trayectorias y objetivos en tierra usando un dirigible y visión artificial

    Directory of Open Access Journals (Sweden)

    Juan Catuche


    Full Text Available Este artículo presenta un sistema robótico autónomo compuesto por un dirigible para interiores, un sistema de vídeo inalámbrico, un PC y una aplicación para el seguimiento de trayectorias y objetivos en tierra con alto contraste. Se ha simplificado el modelo del dirigible con el fin de obtener su modelo lineal, con el cual se han definido objetivos de control como la orientación relativa del dirigible y la distancia de éste a objetivos en tierra. Se ha diseñado una estrategia de control PD tanto para la orientación como para la distancia a los objetivos, alcanzando un tiempo de estabilización de 5s y un sobre-impulso de 5%. La cámara es el único sensor de realimentación, cuyas imágenes son procesadas para: la segmentación de trayectorias, usando la transformada de Hough, el operador de Canny y un filtro mediana; la segmentación de objetos en tierra, usando diferenciación por color en HSI. Se realizaron pruebas para el seguimiento de trayectorias lineales, curvas y una combinación de ellas, arrojando errores de orientación inferiores a ±14º y distancia de ±5pixeles. Se realizaron pruebas para el seguimiento de objetivos en tierra, describiendo trayectorias lineales y curvas, arrojando errores de distancia de ±39 pixeles que corresponden al 8,33% de las dimensiones de la imagen y orientación en el sentido del objetivo de ±12º.

  16. Soil-water retention curve and beginning of monitoring in Tierra Blanca Joven (TBJ)


    Chávez, José A.; López, Reynaldo; Kopecky, Lubomir; Landaverde, José


    In El Salvador during the rainy season or when major earthquakes occur, the areas covered by the volcanic tephras Tierra Blanca Joven (TBJ) suffer mass movements, liquefaction and erosion; causing important en- vironmental, social and economic losses. To start the characterization of these unsaturated soils, suction values of a fall unit of TBJ were obtained using pressure plate, centrifuge and filter paper to build a Soil-Water Retention Curve. The use of this curve into finite elements soft...

  17. Y ¿por qué cambia el planeta Tierra?


    Jaramillo Escobar, Ana María


    José Ignacio Martínez, doctor en Paleoceanografía de la Universidad Nacional de Australia, y Geovany Bedoya, magíster en Recursos Minerales de la Universidad de Colorado, Estados Unidos, conversan sobre los cambios de la Tierra, con un grupo de niños de la Universidad de los niños, programa en el que participan como asesores académicos.

  18. Root canal treatment of mandibular second premolar with four root canals

    Directory of Open Access Journals (Sweden)

    Bander Al-Abdulwahhab


    Full Text Available Variation in the morphology of the root canal system of mandibular premolars has been demonstrated. This diverse morphology challenges for the clinician to clean, shape, and fill the entire root canal system. A case report of a mandibular second premolar with four root canals separated at the apical third and underwent endodontic treatment is presented.

  19. 5 CFR 315.601 - Appointment of former employees of the Canal Zone Merit System or Panama Canal Employment System. (United States)


    ... Canal Zone Merit System or Panama Canal Employment System. 315.601 Section 315.601 Administrative... employees of the Canal Zone Merit System or Panama Canal Employment System. (a) Agency authority. This... Zone Merit System, which was in effect before March 31, 1982, or under the Panama Canal Employment...

  20. Enfermedades infecciosas probablemente dispersadas por los europeos durante el contacto indirecto en Tierra del Fuego

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    Fugassa, Martín H.


    Full Text Available Para la colonización de Norteamérica, ciertos autores sugieren que enfermedades infecciosas actuaron de modo discreto durante un período inicial llamado de Contacto Indirecto. Ello implicaría que los registros históricos con que contamos describan sociedades transformadas. Para Tierra del Fuego, Borrero establece la incertidumbre sobre el tamaño de las poblaciones previas a los primeros relatos de Gusinde y otros. Pretendemos brindar un marco probabilístico sobre las enfermedades infecciosas dispersadas en Tierra del Fuego durante el Contacto Indirecto. Se realizó una evaluación del riesgo de epidemias dentro de las poblaciones nativas (1520-1834. Se consideró el riesgo de contaminación por microorganismos patógenos, según los diversos medios de transporte. Sobre la base de toda la información antes mencionada y de las condiciones ambientales de Tierra del Fuego, construimos un listado de enfermedades infecciosas que probablemente fueron introducidas o aumentadas en frecuencia, dentro del archipiélago durante el período analizado. Este trabajo es parte de un proyecto orientado a analizar la dispersión de las enfermedades en Patagonia Austral

  1. SU-C-303-03: Dosimetric Model of the Beagle Needed for Pre-Clinical Testing of Radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Shang, M; Sands, M; Bolch, W [University of Florida, Gainesville, FL (United States)


    Purpose: Large animal models, most popularly beagles, have been crucial surrogates to humans in determining radiation safety levels of radiopharmaceuticals. This study aims to develop a detailed beagle phantom to accurately approximate organ absorbed doses for therapy nuclear medicine preclinical studies. Methods: A 3D NURBS model was created subordinate to a whole body CT of an adult beagle. Bones were harvested and CT imaged to offer macroscopic skeletal detail. Samples of trabecular spongiosa were cored and imaged to offer microscopic skeletal detail for bone trabeculae and marrow volume fractions. Results: Organ masses in the model are typical of an adult beagle. Trends in volume fractions for skeletal dosimetry are fundamentally similar to those found in existing models of other canine species. Conclusion: This work warrants its use in further investigations of radiation transport calculation for electron and photon dosimetry. This model accurately represents the anatomy of a beagle, and can be directly translated into a useable geometry for a voxel-based Monte Carlo radiation transport program such as MCNP6. Work supported by a grant from the Hyundai Hope on Wheels Foundation for Pediatric Cancer Research.


    Directory of Open Access Journals (Sweden)

    Óscar Darío Beltrán Pérez

    Full Text Available Desde hace algunos años en Colombia se vienen implementando convenios y normas para el adecuado manejo y disposición final de los residuos peligrosos, debido a que la cantidad generada cada vez va en aumento y al impacto adverso que estos residuos presentan en el ser humano y el medio ambiente. La tierra Fuller es un material inorgánico adsorbente (mineral de aluminosilicatos principalmente, utilizado en la industria eléctrica para la regeneración del aceite dieléctrico, un derivado del petróleo empleado como aislante eléctrico y térmico en los transformadores de potencia. Después del proceso de regeneración del aceite, el contenido de hidrocarburos del tipo poliaromáticos (o los PAH por sus siglas en inglés que presenta la tierra Fuller la convierten en un residuo peligroso que requiere de un adecuado tratamiento, para que reduzca su contaminación y permita su reutilización o segura disposición final en un relleno sanitario. Por esto, en este artículo se revisan las tecnologías disponibles para el tratamiento de este tipo de residuo peligroso (tierra Fuller contaminada con aceite dieléctrico, dividiendo los tratamientos en dos corrientes, las tecnologías fisicoquímicas y las biológicas, explorando las alternativas más apropiadas y eficientes para su tratamiento. La escasa información acerca de los tratamientos existentes para la tierra Fuller contaminada con aceite dieléctrico han orientado la revisión en términos de las tecnologías implementadas en suelos contaminados con hidrocarburos siendo válida la analogía debido a las similares características físicas que presenta la tierra Fuller con respecto a un suelo de bajo contenido de carbono.

  3. Características y Problemas de Tenencia de la Tierra en el Sector Agropecuario Colombiano

    Directory of Open Access Journals (Sweden)

    Tobón Restrepo Arturo


    Full Text Available El término “Tenencia” es bastante amplio, pues relaciona la posesión física de un bien sin importar la legitimidad en el dominio de él. En cuanto a la posesión nuestro Código Civil (3 estipula: "La posesión es la tenencia de una cosa determinada con ánimo de señor o dueño, sea que el dueño o el que se la da por tal tenga la cosa por sí misma, o por otra persona que la tenga en lugar y a nombre de él". Para nuestro fin concretemos únicamente en el aspecto de la tierra. El presente estudio se encauza hacia la economía agrícola y la administración rural, más que al aspecto jurídico de la tenencia de la tierra Es bien sabido que en el sistema económico cada factor de producción encierra numerosas especificaciones, además el uso de uno de ellos .implica la combinación en el uso de los demás. Es por ello que al hablar de solución a un problema no se debe decir que se llegue a salvar los obstáculos que impiden el desarrollo económico en el panorama nacional ya que la tenencia de la tierra es un rubro dentro de los muchos con que cuenta el factor tierra. Es claro, que no podría separarse por completo el concepto de tenencia de la tierra de las demás circunstancias de carácter económico en todos sus aspectos; pero las consideraciones que se harán en el transcurso del presente trabajo serán tomadas con cierta tendencia individualista hacia el tema en mención.

  4. [Upper lateral incisor with 2 canals]. (United States)

    Fabra Campos, H


    Clinical case summary of the patient with an upper lateral incisor with two root canals. The suspicion that there might be an anatomic anomaly in the root that includes a complex root canal system was made when an advanced radicular groove was detected in the lingual surface or an excessively enlarged cingulum.

  5. 33 CFR 117.438 - Company Canal. (United States)


    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Company Canal. 117.438 Section 117.438 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Louisiana § 117.438 Company Canal. (a) The draw of the...

  6. The enigma of the lateral canal. (United States)

    Weine, F S


    It is difficult to summarize an article of this type, in which the author is certain that his case has been presented fairly, but is aware that other views that are contrary could be stated and endorsed by pertinent clinical cases. Bearing this fact in mind, I wish to reiterate the following: Lateral canals are demonstrated in endodontic cases with much less frequency than they exist. This variance rarely, if ever, causes an endodontic failure. Some demonstrated lateral canals may really be other conditions. Preoperative evaluation should include examination of radiographs for lateral, as well as periapical, lesions. Lateral canals may be demonstrated by a variety of filling techniques. Careful canal preparation may enhance the frequency of such demonstration. Cases with necrotic pulps probably yield more frequent demonstration than do cases with vital pulps. Lateral canals harboring inflamed and/or infected material may cause pain during endodontic treatment. They may simulate periodontal disease and may cause problems with treatment if present when a tooth is left open for drainage. Periodontal disease may cause pulp exposure via lateral canals located coronally. Improper use of post room may lead to lateral failure from breakdown of tissue in a lateral canal. The enigma of the lateral canal has been the object of description and discussion in many articles, but no one is truly certain of their exact significance in endodontic therapy for the long haul.

  7. Computed Tomography Findings of Mandibular Nutrient Canals. (United States)

    Kawashima, Yusuke; Sekiya, Kotaro; Sasaki, Yusuke; Tsukioka, Tsuneyuki; Muramatsu, Teruaki; Kaneda, Takashi


    The purpose of this study was to assess computed tomography (CT) findings of mandibular nutrient canals using CT images. We retrospectively analyzed the mandibular CT images of 194 consecutive patients. For image analysis such as canal prevalence, location, number, size, shape, and the CT value of nutrient foramina were determined using CT axial images of 0.5 and 3 mm slice thickness. We revealed that the nutrient canals were seen 94.3% in the mandible, mostly seen in the anterior region. By location, nutrient canals were particularly seen between the central and lateral incisors. The mean number of nutrient canals was 2.7. The mean diameter of the nutrient foramen between the central and lateral incisors was 1.0 mm. In about 80% of the cases, foramina between the central and lateral incisors were ovoid. The mean CT value for the nutrient foramina between the central and lateral incisors was 411 HU. Mandibular nutrient canals were ovoid shape, and the mean CT value was 411 HU. By preoperative knowledge of the position and anatomy of the mandibular nutrient canals, complications such as injury to the nutrient canals can be avoided.

  8. Minipig and beagle animal model genomes aid species selection in pharmaceutical discovery and development

    Energy Technology Data Exchange (ETDEWEB)

    Vamathevan, Jessica J., E-mail: [Computational Biology, Quantitative Sciences, GlaxoSmithKline, Stevenage (United Kingdom); Hall, Matthew D.; Hasan, Samiul; Woollard, Peter M. [Computational Biology, Quantitative Sciences, GlaxoSmithKline, Stevenage (United Kingdom); Xu, Meng; Yang, Yulan; Li, Xin; Wang, Xiaoli [BGI-Shenzen, Shenzhen (China); Kenny, Steve [Safety Assessment, PTS, GlaxoSmithKline, Ware (United Kingdom); Brown, James R. [Computational Biology, Quantitative Sciences, GlaxoSmithKline, Collegeville, PA (United States); Huxley-Jones, Julie [UK Platform Technology Sciences (PTS) Operations and Planning, PTS, GlaxoSmithKline, Stevenage (United Kingdom); Lyon, Jon; Haselden, John [Safety Assessment, PTS, GlaxoSmithKline, Ware (United Kingdom); Min, Jiumeng [BGI-Shenzen, Shenzhen (China); Sanseau, Philippe [Computational Biology, Quantitative Sciences, GlaxoSmithKline, Stevenage (United Kingdom)


    Improving drug attrition remains a challenge in pharmaceutical discovery and development. A major cause of early attrition is the demonstration of safety signals which can negate any therapeutic index previously established. Safety attrition needs to be put in context of clinical translation (i.e. human relevance) and is negatively impacted by differences between animal models and human. In order to minimize such an impact, an earlier assessment of pharmacological target homology across animal model species will enhance understanding of the context of animal safety signals and aid species selection during later regulatory toxicology studies. Here we sequenced the genomes of the Sus scrofa Göttingen minipig and the Canis familiaris beagle, two widely used animal species in regulatory safety studies. Comparative analyses of these new genomes with other key model organisms, namely mouse, rat, cynomolgus macaque, rhesus macaque, two related breeds (S. scrofa Duroc and C. familiaris boxer) and human reveal considerable variation in gene content. Key genes in toxicology and metabolism studies, such as the UGT2 family, CYP2D6, and SLCO1A2, displayed unique duplication patterns. Comparisons of 317 known human drug targets revealed surprising variation such as species-specific positive selection, duplication and higher occurrences of pseudogenized targets in beagle (41 genes) relative to minipig (19 genes). These data will facilitate the more effective use of animals in biomedical research. - Highlights: • Genomes of the minipig and beagle dog, two species used in pharmaceutical studies. • First systematic comparative genome analysis of human and six experimental animals. • Key drug toxicology genes display unique duplication patterns across species. • Comparison of 317 drug targets show species-specific evolutionary patterns.

  9. Effects of combination treatment with alendronate and raloxifene on skeletal properties in a beagle dog model.

    Directory of Open Access Journals (Sweden)

    Matthew R Allen

    Full Text Available A growing number of studies have investigated combination treatment as an approach to treat bone disease. The goal of this study was to investigate the combination of alendronate and raloxifene with a particular focus on mechanical properties. To achieve this goal we utilized a large animal model, the beagle dog, used previously by our laboratory to study both alendronate and raloxifene monotherapies. Forty-eight skeletally mature female beagles (1-2 years old received daily oral treatment: saline vehicle (VEH, alendronate (ALN, raloxifene (RAL or both ALN and RAL. After 6 and 12 months of treatment, all animals underwent assessment of bone material properties using in vivo reference point indentation (RPI and skeletal hydration using ultra-short echo magnetic resonance imaging (UTE-MRI. End point measures include imaging, histomorphometry, and mechanical properties. Bone formation rate was significantly lower in iliac crest trabecular bone of animals treated with ALN (-71% and ALN+RAL (-81% compared to VEH. In vivo assessment of properties by RPI yielded minimal differences between groups while UTE-MRI showed a RAL and RAL+ALN treatment regimens resulted in significantly higher bound water compared to VEH (+23 and +18%, respectively. There was no significant difference among groups for DXA- or CT-based measures lumbar vertebra, or femoral diaphysis. Ribs of RAL-treated animals were smaller and less dense compared to VEH and although mechanical properties were lower the material-level properties were equivalent to normal. In conclusion, we present a suite of data in a beagle dog model treated for one year with clinically-relevant doses of alendronate and raloxifene monotherapies or combination treatment with both agents. Despite the expected effects on bone remodeling, our study did not find the expected benefit of ALN to BMD or structural mechanical properties, and thus the viability of the combination therapy remains unclear.

  10. Localization of Helicobacter spp. in the fundic mucosa of laboratory Beagle dogs: an ultrastructural study (United States)


    In dogs Helicobacter spp. are found in all gastric regions usually localized in the surface mucus, gastric glands and parietal cells. The aim of this study was to detail the distribution of Helicobacter spp. in the fundic mucosa of asymptomatic Beagle dogs and their intracellular localization within parietal cells, in order to evaluate species-specific pathogenetic effects on gastric cells. The presence of Helicobacter spp. was investigated by immunohistochemistry, TEM, and PCR in the fundic mucosa of six Beagle dogs. Helicobacter spp. were found in all dogs examined, and H. bizzozeronii and H. felis were identified by PCR and confirmed by TEM. In the lumen of the fundic glands, co-localization was common. H. bizzozeronii was present in larger numbers than H. felis in both intraluminal and intraparietal localization. The amounts of H. bizzozeronii were similar in superficial and basal portions of the glands. H. felis was predominantly localized in the superficial portions of gastric glands but almost absent from the base. Within parietal cells, most Helicobacter organisms were intracanalicular, but intact and degenerate Helicobacter organisms were also visualized free in the cytoplasm or in secondary lysosomes. No specific degenerative lesions were found in infected parietal cells. Helicobacter organisms were also observed within macrophages in the lamina propria. In conclusion, there is a differential distribution of H. bizzozeronii and H. felis in the fundic mucosa of Beagle dogs, and their intracellular localization in parietal cells and macrophages suggests novel pathogenic scenarios for the development of immune response and maintenance of chronic gastritis in dogs. PMID:21366900

  11. Renal function and morphology in aged Beagle dogs before and after hydrocortisone administration.

    Directory of Open Access Journals (Sweden)

    Pascale M Y Smets

    Full Text Available Objectives of this study were to evaluate glomerular filtration rate (GFR, renal structural changes and proteinuria in aged Beagle dogs before and after hydrocortisone (HC administration. Eleven Beagle dogs ≥10 years old were treated with either hydrocortisone (HC group, n = 6 or placebo (control group, n = 5. Urinary markers, GFR and kidney biopsies were evaluated before (T0, during (T16 wks and after discontinuing HC administration (T24 wks. Results indicate that HC administration causes a significant increase in GFR. At all time points except T16 wks, proteinuria was higher in the control group than in the HC group, and there was no significant difference in urinary markers between groups. At T16 wks, proteinuria, urinary albumin-to-creatinine (c ratio, immunoglobulin G/c and retinol-binding protein/c were higher compared to baseline in the HC group. At T0, rare to mild renal lesions were detected in all HC dogs and rare to moderate changes in all control dogs. Glomerulosclerosis progressed in both groups until T24 wks. Tubular atrophy was detected in three HC dogs at T16 wks and T24 wks, but also in five control dogs throughout the study. At every time point, five HC dogs and all control dogs had rare to moderate interstitial inflammation. Rare to mild interstitial fibrosis was found in up to three HC dogs at T16 wks and T24 wks, and severe fibrosis in one HC dog at T24 wks. Up to four control dogs had rare to mild fibrosis at all time points. These findings indicate that clinically healthy, aged Beagle dogs may have considerable renal lesions and proteinuria, which could have implications for experimental or toxicological studies. Additional research is needed to elucidate glucocorticoid effects on renal structure, but functional changes such as hyperfiltration and proteinuria warrant attention to kidney function of canine patients with Cushing's syndrome or receiving exogenous glucocorticoids.

  12. BEAGLE: an application programming interface and high-performance computing library for statistical phylogenetics. (United States)

    Ayres, Daniel L; Darling, Aaron; Zwickl, Derrick J; Beerli, Peter; Holder, Mark T; Lewis, Paul O; Huelsenbeck, John P; Ronquist, Fredrik; Swofford, David L; Cummings, Michael P; Rambaut, Andrew; Suchard, Marc A


    Phylogenetic inference is fundamental to our understanding of most aspects of the origin and evolution of life, and in recent years, there has been a concentration of interest in statistical approaches such as Bayesian inference and maximum likelihood estimation. Yet, for large data sets and realistic or interesting models of evolution, these approaches remain computationally demanding. High-throughput sequencing can yield data for thousands of taxa, but scaling to such problems using serial computing often necessitates the use of nonstatistical or approximate approaches. The recent emergence of graphics processing units (GPUs) provides an opportunity to leverage their excellent floating-point computational performance to accelerate statistical phylogenetic inference. A specialized library for phylogenetic calculation would allow existing software packages to make more effective use of available computer hardware, including GPUs. Adoption of a common library would also make it easier for other emerging computing architectures, such as field programmable gate arrays, to be used in the future. We present BEAGLE, an application programming interface (API) and library for high-performance statistical phylogenetic inference. The API provides a uniform interface for performing phylogenetic likelihood calculations on a variety of compute hardware platforms. The library includes a set of efficient implementations and can currently exploit hardware including GPUs using NVIDIA CUDA, central processing units (CPUs) with Streaming SIMD Extensions and related processor supplementary instruction sets, and multicore CPUs via OpenMP. To demonstrate the advantages of a common API, we have incorporated the library into several popular phylogenetic software packages. The BEAGLE library is free open source software licensed under the Lesser GPL and available from An example client program is available as public domain software.

  13. Effects of combination treatment with alendronate and raloxifene on skeletal properties in a beagle dog model. (United States)

    Allen, Matthew R; McNerny, Erin; Aref, Mohammad; Organ, Jason M; Newman, Christopher L; McGowan, Brian; Jang, Tim; Burr, David B; Brown, Drew M; Hammond, Max; Territo, Paul R; Lin, Chen; Persohn, Scott; Jiang, Lei; Riley, Amanda A; McCarthy, Brian P; Hutchins, Gary D; Wallace, Joseph M


    A growing number of studies have investigated combination treatment as an approach to treat bone disease. The goal of this study was to investigate the combination of alendronate and raloxifene with a particular focus on mechanical properties. To achieve this goal we utilized a large animal model, the beagle dog, used previously by our laboratory to study both alendronate and raloxifene monotherapies. Forty-eight skeletally mature female beagles (1-2 years old) received daily oral treatment: saline vehicle (VEH), alendronate (ALN), raloxifene (RAL) or both ALN and RAL. After 6 and 12 months of treatment, all animals underwent assessment of bone material properties using in vivo reference point indentation (RPI) and skeletal hydration using ultra-short echo magnetic resonance imaging (UTE-MRI). End point measures include imaging, histomorphometry, and mechanical properties. Bone formation rate was significantly lower in iliac crest trabecular bone of animals treated with ALN (-71%) and ALN+RAL (-81%) compared to VEH. In vivo assessment of properties by RPI yielded minimal differences between groups while UTE-MRI showed a RAL and RAL+ALN treatment regimens resulted in significantly higher bound water compared to VEH (+23 and +18%, respectively). There was no significant difference among groups for DXA- or CT-based measures lumbar vertebra, or femoral diaphysis. Ribs of RAL-treated animals were smaller and less dense compared to VEH and although mechanical properties were lower the material-level properties were equivalent to normal. In conclusion, we present a suite of data in a beagle dog model treated for one year with clinically-relevant doses of alendronate and raloxifene monotherapies or combination treatment with both agents. Despite the expected effects on bone remodeling, our study did not find the expected benefit of ALN to BMD or structural mechanical properties, and thus the viability of the combination therapy remains unclear.

  14. Effects of fenugreek, garden cress, and black seed on theophylline pharmacokinetics in beagle dogs. (United States)

    Al-Jenoobi, Fahad I; Ahad, Abdul; Mahrous, Gamal M; Al-Mohizea, Abdullah M; AlKharfy, Khalid M; Al-Suwayeh, Saleh A


    Herb-drug interactions are a serious problem especially for drugs with a narrow therapeutic index, taking into consideration that herbal medicines are commonly used in various parts of the world. The present study investigates the effect of fenugreek, garden cress, and black seed on the pharmacokinetics of theophylline in beagle dogs. Beagle dogs received theophylline (200 mg) orally and blood samples were withdrawn at different time intervals (0.33, 0.66, 1.0, 1.5, 2, 3, 4, 6, 8, 12, 24, and 30 h). After a suitable washout period, each herb was given orally at doses of 25, 7.5, and 2.5 g, twice daily for 7 d. On the eighth day, theophylline was re-administrated orally and blood samples were collected. Plasma concentrations of theophylline were determined using HPLC and pharmacokinetic parameters were calculated using a non-compartmental analysis. Treatment with fenugreek (25 g, orally) lead to a decrease in Cmax and AUC0-t of theophylline of about 28% (p theophylline (2.10 ± 0.24 h versus 3.40 ± 0.74 h), while AUC0-∞ increased by 37.44%. No significant effect was observed for the black seed treatment on theophylline disposition as measured by Cmax, Tmax, AUC0-∞, and CL/F. The concurrent use of fenugreek or garden cress alters theophylline pharmacokinetic behavior in an animal model. This could represent a modulation in cytochrome P450 activity, which is responsible for theophylline metabolism in beagle dogs. Further confirmation of these results in humans will warrant changes in theophylline dosing before the co-administration of such herbs.

  15. Type III apical transportation of root canal

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    Shiv P Mantri


    Full Text Available Procedural accidents leading to complications such as canal transportation have been ascribed to inapt cleaning and shaping concepts. Canal transportation is an undesirable deviation from the natural canal path. Herewith a case of apical transportation of root canal resulting in endodontic retreatment failure and its management is presented. A healthy 21-year-old young male presented discomfort and swelling associated with painful endodontically retreated maxillary incisor. Radiograph revealed periradicular radiolucency involving underfilled 11 and overfilled 12. Insufficiently obturated 11 exhibited apical transportation of canal. This type III transportation was treated by periradicular surgery and repair using white mineral trioxide aggregate (MTA. Comfortable asymptomatic patient presented uneventful healing at third and fourth month recall visits. A decrease in the size of radiolucency in radiograph supported the clinical finding. In the present case, MTA is useful in repairing the transportation defect. The result of these procedures is predictable and successful.

  16. Updated regime equations for alluvial Egyptian canals

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    Fahmy Salah Abdelhaleem


    Full Text Available Real accuracy of several regime relationships for designing stable alluvial channels in Egypt was determined. Extensive field measurements had been carried out on 26 Egyptian stable canals, which cover various categories of irrigation canals starting from distributary, branch to carrier canals in Egypt. Analysis of 1484 velocity profiles for 371 cross sections was employed in order to formulate new regime equations characterizing Egyptian canals. The functional formulations to include the flow depth, cross section area, hydraulic radius and mean velocity were achieved. This research compared the deduced formulas from the measured data with the equations derived by other researchers for stable channel design. It was found that the derived formulas are reliable and could help in the design of Egyptian canals to convey a discharge ranging from 0.11 to 287.5 m3/s (0.0095–24.84 millions m3/day.

  17. A consistent two-mutation model of bone cancer for two data sets of radium-injected beagles

    Energy Technology Data Exchange (ETDEWEB)

    Bijwaard, H.; Brugmans, M.J.P.; Leenhouts, H.P. [National Institute for Public Health and the Environment (RIVM), Bilthoven (Netherlands)


    A two-mutation carcinogenesis model has been applied to model osteosarcoma incidence in two data sets of beagles injected with {sup 226}Ra. Taking age-specific retention into account, the following results have been obtained: (1) a consistent and well-fitting solution for all age and dose groups, (2) mutation rates that are linearly dependent on dose rate, with an exponential decrease for the second mutation at high dose rates, (3) a linear-quadratic dose-effect relationship, which indicates that care should be taken when extrapolating linearly, (4) highest cumulative incidences for injection at young adult age, and highest risks for injection doses of a few kBq kg{sup -1} at these ages, and (5) when scaled appropriately, the beagle model compares fairly well with a description for radium dial painters, suggesting that a consistent model description of bone cancer induction in beagles and humans may be possible. (author)

  18. Surface-seeking radionuclides in the skeleton: current approach and recent developments in biokinetic modelling for humans and beagles

    Energy Technology Data Exchange (ETDEWEB)

    Luciani, A. [ENEA, Radiation Protection Institute, via dei Colli Ne 16, 40136 Bologna (Italy); Polig, E. [Forschungszentrum Karlsruhe, HS/KES, Postfach 3640, 76021 Karlsruhe (Germany)


    In the last decade, the biokinetics of surface-seeking radionuclides in the skeleton has been the object of several studies. Investigations were carried out to determine the kinetics of plutonium and americium in the skeleton of humans and beagles. As a result of these investigations, in recent years the models presented by ICRP in Publication 67 for humans were partially revised, particularly the skeletal part. The aim of the present work is to present recent developments in the biokinetic modelling of surface-seeking radionuclides (plutonium and americium) in beagles and humans. Various assumptions and physiological interpretations of the different approaches to the biokinetic modelling of the skeleton are discussed. Current ICRP concepts and skeleton modelling of plutonium and americium in humans are compared to the latest developments in biokinetic modelling in beagles. (authors)

  19. Flora bucal en perros de la raza Beagle con enfermedad periodontal inducida


    Cabrera García, Alexei; Guerra Barroso Mabel; Soto Cantero Luis; Soca Pérez, Maylin; Rodríguez Sosa, Víctor Manuel; Dominguez López, Heberto Arides; Purón Guzmeli, Carlos Alberto; Macías Hernández, Ileana; Aliaga Aleaga, Yilenis; Acosta Berbes, Anais; Guerrero Contreras, Miladys; Gil Díaz, Felipe Alejandro


    ResumenLa enfermedad periodontal afecta a los perros durante toda su vida y se debe a la acumulación de placa dental bacteriana en las coronas dentales a lo largo de la encía, lo que conlleva a una reacción inflamatoria de la misma, conocida como gingivitis. Con el fin determinar la flora bucal en perros con enfermedad periodontal inducida se estudiaron 10 canes de la raza Beagle que previamente fueron sometidos a una intervención quirúrgica para inducir la enfermedad.SummaryPeriodontal disea...

  20. Epidemiología de las lesiones por mordedura de perro en Tierra del Fuego, Argentina Epidemiology of dog bite lesions in Tierra del Fuego, Argentina

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    Fabián Zanini


    Full Text Available La convivencia del hombre y el perro ha resultado en beneficios mutuos durante miles de años, si bien en el último tiempo han surgido una serie de inconvenientes donde las lesiones por mordeduras ocupan un lugar destacado. El objetivo del presente trabajo fue describir las características epidemiológicas de las lesiones por mordedura de perro ocurridas a lo largo de un año en Tierra del Fuego. Se realizó un estudio observacional descriptivo, transversal, de los pacientes que ingresaron con lesiones por mordedura de perro al Servicio de Guardia Clínica y Pediátrica de los Hospitales y Centros de Salud desde el 1/3/05 hasta el 1/3/06. Se confeccionaron 382 planillas. El 49.5% fueron niños resultando más afectado el grupo de 5-9 años (44.4%; IC95% 37.2-51.8. En adultos correspondió al grupo de 15-24 años (29.5%; IC95% 23.2-36.5. Se registraron más lesiones en varones (57.6% que en mujeres (42.4% (x² = 8.6, p= 0.003. En los meses primavera y verano se registró el 56.5% de las lesiones, en la vía pública el 72.8% de ellas. Los perros de tamaño grande causaron el 49.7% (IC95% 44.6-54.9 de las lesiones. El 89.8% de los ataques fueron causados por perros ajenos. El 55.8% (IC95% 50.6-60.8 se registró en miembros inferiores y el 11% (IC95% 8.1-14.7 en cabeza y cuello. Los datos obtenidos demuestran que en Tierra del Fuego las lesiones por mordedura de perro afectan en forma permanente la salud e impactan en la calidad de vida de la población.The coexistence between man and dog has resulted in mutual benefits during thousands of years, nevertheless some problems have recently arisen where bite injuries have an important role. The aim of this work was to describe the epidemiological characteristics of dog bite lesions which occurred during a year in Tierra del Fuego. A descriptive observational, transversal study of patients who were admitted with dog bite injuries to clinic and pediatric emergency services of hospitals and health

  1. Looking back at Love Canal

    Energy Technology Data Exchange (ETDEWEB)

    Deegan, J. Jr.


    The comprehensive environmental study which describes the results of a monitoring program conducted by EPA at Love Canal is evaluated by EPA's former study director. Attention is focused on the episode's history and the agency's study methods. The aim of the program was to constitute a study team, design a monitoring study, reprogram and reallocate the financial resources needed to conduct the study, and identify and employ contractors who would collect and analyze environmental samples. The agency was directed to ensure the quality of the data acquired from various environmental media and analyzed by numerous laboratories; to integrate, interpret, and report the data; and to assess, from an environmental perspective, the habitability of the area.

  2. Wave Mechanics of the Vestibular Semicircular Canals. (United States)

    Iversen, Marta M; Rabbitt, Richard D


    The semicircular canals are biomechanical sensors responsible for detecting and encoding angular motion of the head in 3D space. Canal afferent neurons provide essential inputs to neural circuits responsible for representation of self-position/orientation in space, and to compensatory circuits including the vestibulo-ocular and vestibulo-collic reflex arcs. In this work we derive, to our knowledge, a new 1D mathematical model quantifying canal biomechanics based on the morphology, dynamics of the inner ear fluids, and membranous labyrinth deformability. The model takes the form of a dispersive wave equation and predicts canal responses to angular motion, sound, and mechanical stimulation. Numerical simulations were carried out for the morphology of the human lateral canal using known physical properties of the endolymph and perilymph in three diverse conditions: surgical plugging, rotation, and mechanical indentation. The model reproduces frequency-dependent attenuation and phase shift in cases of canal plugging. During rotation, duct deformability extends the frequency bandwidth and enhances the high frequency gain. Mechanical indentation of the membranous duct at high frequencies evokes traveling waves that move away from the location of indentation and at low frequencies compels endolymph displacement along the canal. These results demonstrate the importance of the conformal perilymph-filled bony labyrinth to pressure changes and to high frequency sound and vibration. Published by Elsevier Inc.

  3. How to bond to root canal dentin (United States)

    Nica, Luminita; Todea, Carmen; Furtos, Gabriel; Baldea, Bogdan


    Bonding to root canal dentin may be difficult due to various factors: the structural characteristic of the root canal dentin, which is different from that of the coronal dentin; the presence of the organic tissue of the dental pulp inside the root canal, which has to be removed during the cleaning-shaping of the root canal system; the smear-layer resulted after mechanical instrumentation, which may interfere with the adhesion of the filling materials; the type of the irrigants used in the cleaning protocol; the type of the sealer and core material used in the obturation of the endodontic space; the type of the materials used for the restoration of the endodontically treated teeth. The influence of the cleaning protocol, of the root canal filling material, of the type of the adhesive system used in the restoration of the treated teeth and of the region of the root canal, on the adhesion of several filling and restorative materials to root canal dentin was evaluated in the push-out bond strength test on 1-mm thick slices of endodontically treated human teeth. The results showed that all these factors have a statistically significant influence on the push-out bond strength. Formation of resin tags between radicular dentin and the investigated materials was observed in some of the samples at SEM analysis.

  4. Panama Canal Watershed Experiment- Agua Salud Project (United States)

    Stallard, Robert F.; Ogden, Fred L.; Elsenbeer, Helmut; Hall, Jefferson S.


    The Agua Salud Project utilizes the Panama Canal’s (Canal) central role in world commerce to focus global attention on the ecosystem services provided by tropical forests. The Canal was one of the great engineering projects in the world. Completed in 1914, after almost a decade of concerted effort, its 80 km length greatly shortened the voyage between the Atlantic and Pacific Oceans. An entire class of ships, the Panamax, has been constructed to maximize the amount of cargo that can be carried in a Canal passage. In today’s parlance, the Canal is a “green” operation, powered largely by water (Table 1). The locks, three pairs on each end with a net lift of 27 meters, are gravity fed. For each ton of cargo that is transferred from ocean to ocean, about 13 tons of water (m3) are used. Lake Gatún forms much of the waterway in the Canal transect. Hydroelectricity is generated at the Gatún dam, whenever there is surplus water, and at Madden Dam (completed in 1936) when water is transferred from Lake Alhajuela to Lake Gatún. The Canal watershed is the source of drinking water for Panama City and Colon City, at either end of the Canal, and numerous towns in between.

  5. Radiographic evaluation of obesity-caused oppression of the thoracic cavity in beagles. (United States)

    Morooka, Toshio; Niiyama, Masayoshi; Kougo, Aki; Soya, Mayumi; Nunome, Katsunori


    Thoracic radiographs of fifteen beagles with mild-to-moderate obesity revealed that oppression of the thoracic cavity increased with increasing degree of obesity. Oppression of the thoracic cavity was evaluated based on the length, depth, width and area of the thoracic cavity. To obtain thoracic radiographs at the terminal inspiration and expiration phases, thoracic fluororadiographs were recorded with a digital video camera. Bodyweight and the depth of the back fat layer at the seventh lumbar vertebra (DB, measured by ultrasonography) were used as indicators of the degree of obesity. The length of the thoracic cavity tended to become shorter and the depth and width of the thoracic cavity tended to increase as bodyweight increased and as DB increased. On the other hand, the area of the thoracic cavity was not clearly related to bodyweight or DB. These results suggest that oppression of the thoracic cavity due to the cranial shift of the diaphragm is compensated for by increases in the depth and width of the thoracic cavity in beagles with mild-to-moderate obesity.

  6. Immunotherapy in a natural model of Abeta pathogenesis: the aging beagle. (United States)

    Vasilevko, Vitaly; Head, Elizabeth


    Alzheimer disease (AD) is the most common form of dementia in the elderly and the number of individuals developing the disease is rapidly rising. Interventions focused on reducing beta-amyloid (Abeta), a component of senile plaques within the AD brain offer a promising approach to prevent or slow disease progression. In this review, we describe the immune system and cognitive and neurobiological features of a natural model of human brain aging, the beagle. The immune system of dogs shares many features of the human immune system, including developmental and aging characteristics. Further, dogs naturally accumulate human sequence Abeta as they age, which coincides with declines in learning and memory. A longitudinal study (approximately 2 years) of the response of aged beagles to vaccination with fibrillar Abeta1-42 indicated that despite significant clearance of Abeta, there were limited benefits in cognitive function. However, there was evidence for maintenance of executive function over time. These results are strikingly similar to reports of human clinical immunotherapy trials. We propose that the canine model complements existing animal models and will be helpful in developing new vaccine approaches to slowing or preventing Abeta pathology that can be translated to human clinical trials.

  7. Pathologic changes in the hearts of beagles irradiated with fractionated fast neutrons or photons

    Energy Technology Data Exchange (ETDEWEB)

    Zook, B.C. (George Washington Univ. Medical Center, Washington, DC); Bradley, E.W.; Casarett, G.W.; Rogers, C.C.


    Thirty-nine adult male purebred beagles received either fast-neutron or photon irradiation to the right thorax to determine the effects on pulmonary tissue. The right atrium, a small portion of the right ventricle, and the right anterior abdomen were included in the field. Twenty-four dogs (six/group) received fast neutrons with a mean energy of 15 MeV to doses of 1000, 1500, 2250, or 3375 rad in four fractions per week for 6 weeks. Fifteen dogs received 3000, 4500, or 6750 rad of photons (five/group) in an identical fractionation pattern. Fourteen dogs died or were euthanatized in extremis between 47 and 708 days after radiation because of radiation damage to digestive organs. Six other dogs died of anesthetic accidents between 196 and 1144 days after radiation; these deaths were probably related to hepatic dysfunction. Two neutron-irradiated dogs developed cardiac neoplasms after 396 and 1624 days. One dog died of a myocardial infarct and one died of an unrelated infection. The major atrial lesions were hemorrhage and necrosis of myocardial cells in dogs that died 47-109 days postirradiation. Myocardial and endocardial fibrosis were most extensive in dogs that died 84 or more days following irradiation. All beagles had degenerative and occlusive vascular changes associated with atrial lesions. The relative biological effectiveness of fast neutrons for pathologic injury of the heart was estimated to be between 4 and 5.

  8. Framing Space: UK Newspaper Reporting of the Beagle 2 and Cassini-Huygens Space Missions (United States)

    Jergovic, B.; Miller, S.


    Relatively little scholarly work has been done on looking at the portrayal of astronomy and space science in the media. This short article examines the UK press coverage of two space missions: the Beagle 2 mission to Mars and the Cassini-Huygens mission to Saturn and its moon Titan. In both cases, the leading scientists exerted a strong influence on what journalists reported, to the extent that some journalists appeared to be almost "embedded" in the mission. For the most part the coverage is positive in tone and the loss of the Beagle 2 spacecraft does not reflect badly on the (later) Cassini-Huygens coverage. Most journalists only covered the actual mission events and, in the case of Huygens, did not follow up to cover the peer-reviewed scientific articles that appeared later. Off-the-cuff comments made by scientists at the time of the missions were widely reported. There appears to be an appreciation by journalists and (by inference) their readership that this was science in the making, and that allowances should be made if these comments later turned out to be inaccurate.

  9. Seasonality of larvae of Brachyura and Anomura (Crustacea Decapoda in the Beagle Channel, Argentina

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    Gustavo A. Lovrich


    Full Text Available This is the first study in the Beagle Channel that reports the larval seasonal distribution, abundance and duration of the larval stages of Anomura and Brachyura, on the basis of a fortnightly sampling programme. An identification key to the specific level of zoeal stages is included. Between September 1987 and March 1989, 304 plankton samples were taken by means of oblique hauls from the bottom to the sea-surface. Eighty-five percent of the samples were taken shallower than 60 m depth. Decapod larvae occurred only in spring and summer. All but two taxa showed a single cohort of larvae which emerge at the beginning of the spring. A second cohort of Munida spp. and Halicarcinus planatus also occurred during summer. The most abundant taxa were Munida spp. (312 larvae ? 10 m-3, Peltarion spinosulum (288 larvae ? 10 m-3,, H. planatus (143 larvae ? 10 m-3, and Pagurus spp. (79 larvae ? 10 m-3, which represented 97% of the total larvae collected. Larvae of Pinnotheridae, Eurypodius latreillii, Libidoclaea granaria, and Paralomis granulosa were about an order of magnitude less abundant. Relative abundances of larvae correspond to relative abundances of the respective benthic stages. The absence of certain larval stages or of certain species (Acanthocyclus albatrossis and Lithodes santolla probably indicates their differential distribution within the Beagle Channel. Particularly, lithodid larvae may have benthic or epibenthic habits.

  10. Energy density of sub-Antarctic fishes from the Beagle Channel. (United States)

    Fernández, D A; Lattuca, M E; Boy, C C; Pérez, A F; Ceballos, S G; Vanella, F A; Morriconi, E R; Malanga, G F; Aureliano, D R; Rimbau, S; Calvo, J


    The energy density (ED) of nine species of sub-Antarctic fishes was estimated by calorimetry. The fish, seven notothenioids, one atherinopsid and one galaxiid, represents some of the more abundant species in the ichthyofauna of the Beagle Channel. Principal-components analysis (PCA) of the ED of the different organs/tissues indicated that PC(1) and PC(2) accounted for 87% of the variability. Separation along PC(1) corresponded to differences in muscle and liver energy densities whereas separation along PC(2) corresponded to differences in the ED of the gonads. Differences between species were significant except for P. sima. Inclusion of the gonadosomatic index (GSI) as an explanatory variable enabled us to establish the existence of energy transfer from muscle and liver to the gonads in ripe P. tessellata females. Total ED values varied between 4.21 and 6.26 kJ g(-1), the pelagic Odontesthes sp. being the species with the highest ED. A significant relationship between ED and muscle dry weight (DW(M)) was found for all the species except P. tessellata. These data are the first direct estimates of ED of fishes from the Beagle Channel.

  11. Mesozooplankton assemblages in two bays in the Beagle Channel (Argentina during January, 2001

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    Melisa Daiana Fernández-Severini


    Full Text Available This paper describes the composition and abundance of mesozooplankton of Bahía Ushuaia and Bahía Golondrina. These small bays are located in the northern Beagle Channel. Sampling was carried out from January 20 to 23, 2001 and samples were collected from the upper layer at nine stations. This study is the first research on mesozooplankton in this part of the Beagle Channel. Due to their dominance in the mesozooplankton community, we compared our Copepoda data with those reported by other authors from Antarctic coastal environments. By applying cluster analysis, we found two station groups in both bays: one in slightly polluted zones and the other in undisturbed external zones. Four assemblages in Bahía Ushuaia and two in Bahía Golondrina were determined by using non-metric multidimensional scaling (MDS and cluster analysis. Mesozooplanktonic assemblages showed a certain resemblance in zones with and without anthropogenic influence. Most of the copepod species in our samples are typical of the sub-Antarctic region. Oithona similis (=O. helgolandica sensu Ramírez, 1966, Oncaea curvata, and Ctenocalanus citer show either similar or higher abundances at Antarctic coastal sites, including the upper layer in oceanic areas, in comparison with sub-Antarctic coastal localities. This suggests that, in agreement with other findings, the Polar Front is probably not a major geographic boundary for the distribution of these species.

  12. Baseline defense system of commercial male king crab Lithodes santolla from the Beagle Channel. (United States)

    Schvezov, N; Lovrich, G A; Florentín, O; Romero, M C


    Environmental and physiological variations influence the steady-state concentration of free oxygen radicals in cells. Because of the seasonal life cycle of Lithodes santolla in the Beagle Channel, a baseline study of the antioxidant physiological variations along the seasons is necessary for a better understanding of its ecophysiology. The aim of this study was to evaluate the seasonal variations in gills, hemolymph, muscle and hepatopancreas of the: i) enzymatic activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione transferase; ii) ascorbic acid and total glutathione; iii) lipid peroxidation and protein oxidation; iv) glucose, proteins and pH. Seasonality found in the antioxidant defense system of L. santolla from the Beagle Channel acts in a collaborative way during the most relevant life cycle phases (reproduction and molting), avoiding a long term oxidative stress. The antioxidant system also shows changes in the enzymatic activities likely caused by the environmental factors, such as low temperatures during winter and spring seasons. Copyright © 2014 Elsevier Inc. All rights reserved.

  13. Evaluation of pharmacokinetics underlies the collaborated usage of lamivudine and oxymatrine in beagle dogs

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    Zhenbao Li


    Full Text Available Combinational therapy of lamivudine and oxymatrine has been employed in the battle against hepatitis B virus in clinical setting. However, the pharmacokinetic behavior of the drug or active metabolism in intravenous/oral co-administration regime is poorly investigated. Herein, we evaluated the pharmacokinetic characteristic through a tailor-designed 3 way crossover-Latin square experiment in adult male beagle dogs. Six dogs were randomly treated by intravenous administration of lamivudine (2.5 mg/kg, oxymatrine (15 mg/kg and combinational dosage, named as intravenous regime. Meanwhile the other six dogs were orally administrated with lamivudine (2.5 mg/kg, oxymatrine (15 mg/kg and combinational dosage, named as oral regime. The pharmacokinetic feature in simultaneous oral treatment appeared to have no significant difference when compared with individual administration, even including matrine, the active metabolite of oxymatrine. In intravenous regime, the main pharmacokinetic parameters of simultaneous administration were nearly consistent with intravenous regime remedy. The collaborated application of lamivudine and oxymatrine contributed to non-distinctive pharmacokinetic fluctuations of beagle dogs in intravenous/oral regime, compared with individual employment, which established a vital base for the clinical co-administration against hepatitis B. Furthermore, the present study demonstrated that the determination of pharmacokinetics between combinational and individual therapy might assist in the development of drug compatibility in clinical therapy.

  14. La tierra comunal en Andalucía durante la Edad Moderna

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    Antonio Miguel BERNAL


    Full Text Available RESUMEN: A partir de la ambigüedad conceptual que define a las tierras comunales en Andalucía se estudian, para los siglos XV al XVIII, tres aspectos fundamentales: cómo se llega a formar la propiedad comunal; a través de qué mecanismos —jurídicos y económicos— se van reduciendo las tierras comunales a propiedad privada; y, por último, qué funcionalidad económica habían tenido los comunales en el contexto del sistema agrario andaluz. La escasa población andaluza en la Edad Moderna y la gran disponibilidad de tierras incultas favorecieron, en el inicio, la aparición de comunales, bajo diversas modalidades, si bien la presión señorial y de las oligarquías urbanas consiguieron privatizarlos; en tales procesos se fundamentan las luchas agrarias andaluzas.ABSTRACT: Taking into account the conceptual ambiguity defining communal lands in Andalusia, we studied three fundamental aspects with regard to the 15th- 18th centuries: how communal property was formed, the mechanisms (legal and economic that led to the converting of communal lands into prívate property and, finally, the economic functionality that communal lands had in the context of the Andalusian agricultural system. The sparse Andalusian population during the early modern age and the availability of a large quantity of uncultivated land favoured, at the beginning, the formation of different kinds of communal land, althought it was the pressure form the upper classes and the urban oligarchies that led to its privatization; such processes are the basis of Andalusian agricultural disputes.

  15. Mapa de usos potenciales de la tierra de Galicia. Una perspectiva arqueológica

    Directory of Open Access Journals (Sweden)

    Currás Refojos, Brais X.


    Full Text Available A digital version of the map of potential land use of Galicia is here presented, adapted to a reclassification of three types of potential land use, established using historical criteria. An analytical procedure is developed to select the land-types and the system used for their digitalisation. In the final part the map is used to critically revise the possibilities of using this record for territorial characterisation in archaeological research.La cartografía de usos potenciales de la tierra es una herramienta de gran utilidad en el estudio de las formas de poblamiento y su relación con la explotación de los recursos agrícolas desde el enfoque de la arqueología del paisaje. La digitalización de esta información permite su aplicación sistemática en el análisis del territorio mediante SIG. En este trabajo se presenta el Mapa de usos potenciales de la tierra de Galicia, reclasificado en tres tipos establecidos en función de criterios históricos. Se muestra el procedimiento analítico desarrollado para la selección y clasificación de los tipos de tierra y su sistema de digitalización. Se examina la validez de esta fuente para la investigación arqueológica de las formas agrícolas en la antigu.edad desde el punto de vista del análisis del territorio y se ofrece una visión crítica sobre sus ventajas y limitaciones.

  16. Mandibular Canal Enlargement: Clinical and Radiological Characteristics

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    Chong Jun Ai


    Full Text Available Enlargement of the mandibular canal is a rare radiological finding. Clinically, it may or may not be associated with sensory deficits. We report four cases of widening of the mandibular canal observed with various methods of imaging with different clinical characteristics. We describe this unique radiological finding and elaborate the importance of quality assessment of the imaging that is vital for accurate diagnosis and treatment planning. Clinicians should be mindful when assessing the imaging whenever the size of the mandibular canal is implicated. The case ranged from a benign tumor to malignancy, radiological errors, and artifacts. A more superior imaging or treatment modality was necessary to ascertain the diagnosis.

  17. El acceso a la tierra asunto clave para las mujeres campesinas en antioquia, colombia.


    Zuluaga Sánchez, Gloria Patricia


    Se recogen los principales resultados de la investigación sobre la tenencia de la tierra y sus implicaciones en la vida de las mujeres de dos organizaciones campesinas ubicadas en el Departamento de Antioquia – Colombia, las cuales se desenvuelven en un contexto de agricultura campesina, donde se presenta una tendencia a la feminización de la pequeña agricultura, debido a que los hombres emigran a otras actividades económicas y/o se vinculan a grupos armados. Los objetivos fueron documentar y...

  18. Clientelismo y recomposici??n de oligarqu??as en Tierra Caliente (M??xico)


    Montes Vega, Octavio Augusto


    Este trabajo expone una visi??n general sobre la combinaci??n de mecanismos formales e informales constructores de la cultura pol??tica en M??xico, tomando como unidad anal??tica a la Tierra Caliente del Medio Balsas y los procesos de legitimaci??n por los que facciones e individuos relacionados con la defensa de la regi??n logran ejercer el poder pol??tico local. El texto toma un repertorio de figuras explicativas del orden jer??rquico-familiar-pol??tico que controla los mecanismos en las re...

  19. Arquitectura de tierra -histórica y moderna- en Italia


    Galdieri, Eugenio


    This work about the history of mud constructions in Italy -both of brick and formwork- gives an exposition of geographical zones where those are located, the kind of uses so as their possible historic origins, among which the author points the strong connections with Spanish adobe constructions, both in Cagliars (Aragonese influence) and in Oristano (Castilian influence).El trabajo de carácter histórico sobre las construcciones con tierra en Italia, tanto de adobe como de tapial presenta una ...

  20. An ecological basis for Nothofagus pumilio Forest management in Tierra del Fuego


    Richter, Laura; Frangi, Jorge Luis


    Tradicionalmente en la Argentina, la ecología forestal y la silvicultura han marchado en general por caminos separados. La información ecológica apropiada puede ser aprovechada para un mejor manejo del bosque. La especie nativa Nothofagus pumilio (n.v. lenga) y los bosques que forma en la Tierra del Fuego poseen características biológicas y ecológicas favorables y desfavorables para la producción de madera que pueden diferir si son otros los objetivos del manejo. Estas características estruct...

  1. Las normativas de construcción con tierra en el mundo

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    Cid, J.


    Full Text Available For centuries, earth has been used as a construction material. Nevertheless, the normative in this matter is very scattered, and in the most developed countries, carrying out a construction with this material implies a variety of technical and legal problems. This article analyzes, in an international level, the normative panorama about constructions with earth, analyzing fifty five standards and regulations of countries all around the five continents; these represent the state of art that normalizes the earth as a construction material. It is a study indexed on the actual procedures and regulations developed by the national organisms of normalization or correspondent authorities. The standards and the organisms that produce them appear, analyzing the structure and the content of each one. We have studied and analyzed the most relevant aspects, such as stabilization, soil selections, the requisites of the products and the existent test, comparing the diverse normative. The knowledge from this study could be very useful for the development of future standards and as a reference for architects and engineers that work with earth.

    La tierra ha sido utilizada como material de construcción desde hace siglos. No obstante, la normativa al respecto está muy dispersa, y en la mayoría de países desarrollados surgen numerosos problemas técnicos y legales para llevar a cabo una construcción con este material. Este artículo estudia el panorama normativo para las construcciones con tierra cruda a nivel internacional, analizando cincuenta y cinco normas y reglamentos de países repartidos por los cinco continentes, que representan el estado del arte de la normalización de la tierra cruda como material de construcción. Es un estudio referenciado sobre las normas y reglamentos vigentes desarrollados por los organismos nacionales de normalización o autoridades correspondientes. Se presentan las normativas y los organismos que las emiten

  2. El surgimiento del Orden Internacional Moderno según Tierra y Mar de Carl Schmitt


    Solano Palacio, Carlos Alberto


    El propósito de esta disertación es rescatar las interpretaciones de Tierra y Mar en lo que se refiere al surgimiento del Orden Internacional Moderno, con el objetivo de explicar la percepción de los acontecimientos por parte de Carl Schmitt y su aporte filosófico-jurídico a la comprensión de la historia y teoría de las Relaciones Internacionales. La particularidad de esta obra de Schmitt es su estilo profundo: la variedad y amplitud de temas que abarca, que contrasta con la brevedad del tex...



    Gilberto A. Gamboa-Bernal


    La Declaración Universal de los Derechos Humanos reconoce la familia como la célula básica de la sociedad, resalta su importancia, la necesidad de protegerla, de promocionarla, como elemento natural y fundamental de la sociedad. Para reflexionar sobre los efectos que la cultura actual tiene en la familia es importante partir de la situación como se presenta ahora, para luego pasar a plantear los cambios que se vean necesarios, para asegurar su propio futuro y el de su habitad que es la Tierra...

  4. Primeros ensayos petrofísicos sobre la roca dimensional de Tierra del Fuego


    Rogelio Daniel Acevedo; Mauricio González-Guillot


    Se muestran aquí los primeros ensayos de laboratorio sobre las rocas dimensionales de Tierra del Fuego, región que tenía una potencialidad no evaluada respecto al uso posible de este recurso nativo. Nunca habían sido empleadas hasta ahora rocas duras (ígneas) ni pizarras en la construcción residencial, el revestimiento de fachadas ó pisos. Dos pequeñas canteras de rocas plutónicas han sido abiertas recientemente: una de ellas en el cerro Jeu-Jepén, aprovechada para la construcción de la escol...

  5. Que cante la gallina, no solo el gallo:memoria, mujeres y tierra


    Pinto Velásquez, Eliana


    Las mujeres rurales han desempañado un papel significativo en la construcción del territorio colombiano, por lo que sus experiencias de vida y de resistencia frente al conflicto armado en el país merecen ser contadas y tenidas en cuenta en las memorias colectivas. A partir de sus narrativas, recogidas en el trabajo investigativo en la línea de tierra y conflicto del Grupo de Memoria Histórica de la Comisión Nacional de Reparación y Reconciliación, en Córdoba, Sucre y la Región de Montes de Ma...



    Noelia I. Paredes; Consolo, Verónica F.; Verónica A. Pancotto; Christian Fritz; Barrera, Marcelo D.; Angélica M. Arambarri; Salerno, Graciela L.


    En el Hemisferio Sur las turberas almacenan grandes cantidades de carbono en el suelo. A pesar de su importancia en el ciclo global del carbono, se sabe poco acerca de los procesos de descomposición y su diversidad fúngica. El presente estudio se realizó para describir la composición de hongos filamen - tosos en dos profundidades de una turbera compacta donde las especies vegetales predominantes son Astelia (Asteliaceae) y Donatia (Donatiaceae) en Moat, Tierra del Fuego, Argentina. De 48 mues...

  7. Un método para evaluar la aptitud de las tierras con fines de riego y drenaje

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    Arevalo V. Gloria


    Full Text Available Se planteó una metodología para clasificar la aptitud de las tierras para uso bajo riego y drenaje como base para crear alternativas de manejo. La metodología propone agrupar los suelos en Unidades de Manejo de tierras(UMAT como unidades cartográficas y ecológicas similares en cuanto a necesidad de manejo. Son éstas las que se evalúan con respecto a unos Tipos de Manejo bajo Riego (TMR a través de cualidades de la tierra. Cada cualidad incluye características del suelo y requerimiento de manejo de riego. El acercamiento entre las condiciones de la tierra y los requerimientos de manejo del riego definen la clase de aptitud. Sobre las tierras con mejor aptitud para determinado método de riego se reevalúa en cuanto a su aptitud para la producción de cultivos denominado Tipo de Uso de la Tierra (TUT. Se pueden establecer alternativas de manejo y mejoramiento para encontrar la aptitud potencial.A land capability classification method for irrigated and drained lands was outlined in order to build up management alternatives. This methodology suggests the grouping of soils in Land Management Units (LMU as cartographical and ecological units similar in its management needs. These units are those evaluated with respect to Irrigation Management Types (ITM taking account of land qualities which relate to soil physical and chemical characteristics and the irrigation management requirements. The enclosure of land conditions and its irrigation management requirement defines the land capability class. Lands with the best land capability for irrigation are afterwards reevaluated from the crop production stand point, leading to a new group named Land Use Type. This methodology allows to choose several alternatives for the proper land use under irrigation practices without damaging soil and water resources.

  8. Scanning electron microscopy investigation of canal cleaning after canal preparation with nickel titanium files

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    Živković Slavoljub


    Full Text Available Introduction. Root canal preparation is the most important phase of endodontic procedure and it consists of adequate canal space cleaning and shaping. In recent years, rotary instruments and techniques have gained importance because of the great efficacy, speed and safety of the preparation procedure. Objective. The aim of this research was to investigate the influence of different NiTi files on the canal wall cleaning quality, residual dentine debris and smear layer. Methods. The research was conducted on extracted human teeth in vitro conditions. Teeth were divided in 7 main groups depending on the kind of instruments used for root canal preparation: ProTaper, GT, ProFile, K-3, FlexMaster, hand ProTaper and hand GT. Root canal preparation was accomplished by crown-down technique. Prepared samples were assessed on scanning electron microscopy JEOL, JSM-6460 LV. The evaluation of dentine debris was done with 500x magnification, and the evaluation of smear layer with 1,000 times magnification. Quantitive assessment of dentine debris and smear layer was done according to the criteria of Hulsmann. Results. The least amount of debris and smear layer has been found in canals shaped with ProFile instruments, and the largest amount in canals shaped with FlexMaster instruments. Canal cleaning efficacy of hand GT and ProTaper files has been similar to cleaning efficacy of rotary NiTi files. Statistic analysis has shown a significant difference in amount of dentine debris and smear layer on the canal walls between sample groups shaped with different instruments. Conclusion. Completely clean canals have not been found in any tested group of instruments. The largest amount of debris and smear layer has been found in the apical third of all canals. The design and the type of endodontic instruments influence the efficacy of the canal cleaning.

  9. Biomechanical behaviour of the periodontal ligament of the beagle dog during the first 5 hours of orthodontic force application.

    NARCIS (Netherlands)

    Jonsdottir, S.H.; Giesen, E.B.W.; Maltha, J.C.


    The aim of this study was to describe the mechanical behaviour of the periodontal ligament (PDL) in response to loading with different forces for a period of 5 hours. Seven young adult male beagle dogs (age 1.0-1.5 years) were used. After extractions and placement of implants, custom-made appliances

  10. Description of a New Opecoelid Trematode Species from Nototheniid Fish in the Beagle Channel (Sub-Antarctica)

    National Research Council Canada - National Science Library

    Zdzisław Laskowski; Witold Jeżewski; Krzysztof Zdzitowiecki


    Macvicaria magellanica n. sp. (Digenea: Opecoelidae) is the third representative of this genus occurring in fish in the Magellanic sub-region of sub-Antarctica and the first one found in sub-coastal waters in this area (the Beagle Channel...

  11. Adenocarcinomas of the stomach induced in beagle dogs by oral administration of N-ethyl-N'-nitro-N-nitrosoguanidine. (United States)

    Kurihara, M; Shirakabe, H; Izumi, T; Miyasaka, K; Yamaya, F; Maruyama, T; Yasui, A


    Two 8-month-old and two 4-month-old male beagle dogs received 250 ml of 150 microgram/ml solution of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) and 2% Tween 60 mixed with a pellet diet twice a day for 8 months as the same methods used for mongrel dogs in our first report [Juntendo Medical Jouranl 19, 579-583 (1973)]. Gastric carcinomas with distant lymph nodes metastases occurred in three beagle dogs except for one died from anesthesia at the endoscopy. Metastases to the liver were observed in two beagles. In the most long-lived beagles, peritonitis carcinomatosa with ascites and metastases to the liver, lungs, bones, and skin were found. Main gastric tumors were located at the subcardia in two dogs (elevated tumor in dog No. 6, ulcerated tumor in dog No. 8), but in dog No 7 at the angulus (ulcerated tumor). Histologically, carcinomas were composed of poorly differentiated adenocarcinoma, signet-ring cell carcinoma, tubular adenocarcinoma, and undifferentiated adenocarcinoma. In all of three dogs which developed adenocarcinoma of the stomach, Stewart's criteria were completely satisifed. Using our methods the target organ is limited only to the stomach, without any sarcomatous lesion of the intestines.

  12. Tierras, montes y aguas: Apuntes sobre energía, medio ambiente y justicia en las Américas


    Soluri, John


    Resumen El título de este ensayo adopta las palabras del Plan de Ayala (1911) por medio del cual las fuerzas de Emiliano Zapata declararon su concepto de justicia durante la Revolución Mexicana. Desde la revolución hasta la actualidad, distintos historiadores se han dedicado al estudio de conflictos sobre la tierra en América Latina, pero han prestado mucho menos atención a la problemática de las aguas y montes.1 No cabe duda que la tierra ha sido al centro de muchos conflictos históricos y ...

  13. 50 años de historia en el Instituto de Ciencias de la Tierra Jaume Almera


    Anadón, Pere; Torné, Montserrat; Fernandez-Turiel, J.L.; Diaz, J.


    El Instituto de Ciencias de la Tierra Jaume Almera (ICTJA) es un centro de investigación especializado en el estudio del Sistema Tierra, así como en la formación de pe rsonal y asesoramiento de entidades públicas y privadas. El Instituto forma parte del Consejo Superior de Investigacion es Científicas (CSIC). En 2015, el ICTJA-CSIC celebró su 50 aniversario. Desde su fundación en 1965 como un instituto de Geología del CSIC en Barcelona, el ICTJA ha evolucionado hast...

  14. Incidence of accessory canals in Japanese anterior maxillary teeth following root canal filling ex vivo. (United States)

    Adorno, C G; Yoshioka, T; Suda, H


    To investigate the vertical and horizontal distribution and the incidence of accessory canals in Japanese maxillary anterior teeth following root filling. The study included maxillary teeth; 69 central incisors, 61 lateral incisors and 31 canines. After the canal systems had been dyed and root canal instrumentation had been carried out, all prepared canals were filled with gutta-percha without using sealer. Transparent specimens were then obtained and examined with a digital microscope for horizontal and vertical distributions of accessory canals. The incidence of teeth with accessory canals in the apical 3 mm was 46%, 29% and 38% for the maxillary central incisors, lateral incisors and canines, respectively. The horizontal distribution was mainly buccal for central incisors, palatal for lateral incisors and distal and palatal for canines. There was a significant difference (P < 0.05) between the apical 3 mm and the rest of the root (16%, 20% and 19% for the maxillary central incisors, lateral incisors and canines, respectively) in terms of the presence of accessory canals. A high percentage of accessory canals can be found in apical 3 mm of the root. The horizontal distribution of accessory canals differed amongst the tooth types studied.

  15. Canal and isthmus debridement efficacy using a sonic irrigation technique in a closed-canal system. (United States)

    Johnson, Meenal; Sidow, Stephanie J; Looney, Stephen W; Lindsey, Kimberly; Niu, Li-na; Tay, Franklin R


    This in vitro study compared debridement efficacies of a sonic irrigation technique (Vibringe; Cavex Holland BV, Haarlem, The Netherlands) with side-vented needle irrigation (SNI) in the mesiobuccal root of maxillary first molars. Twenty roots with narrow isthmuses (≤ 1/4 canal diameter) were selected using micro-computed tomography scanning. Collagen solution was injected into canals/isthmuses and reconstituted with NH(4)OH to simulate canal debris. Each root was sealed apically and embedded in polyvinyl siloxane simulating a closed-canal system. Canals were instrumented to size 40/.04 taper 1 mm short of the anatomic apex. The final irrigation was performed with the Vibringe or SNI. Roots were demineralized, sectioned at 6 levels (1.2-3.2 mm) from the anatomic apex, and stained using Masson trichrome stain. The areas occupied by canals and isthmus and the debris-containing areas were statistically analyzed with repeated-measures analyses using "irrigation technique" as the between factor and "canal level" as the within factor (α = 0.05). Canals had significantly more debris at 1.2 and 1.6 mm (P .05). Considerably more debris remained at 1.2 and 2.0 mm for the Vibringe (P < .05). A significant difference was observed between the canal and the isthmus (P < .001). There is no difference between the Vibringe and SNI in their overall debridement efficacy in apical one third of the mesiobuccal root of maxillary first molars. Published by Elsevier Inc.

  16. Semicircular canal modeling in human perception. (United States)

    Asadi, Houshyar; Mohamed, Shady; Lim, Chee Peng; Nahavandi, Saeid; Nalivaiko, Eugene


    The human vestibular system is a sensory and equilibrium system that manages and controls the human sense of balance and movement. It is the main sensor humans use to perceive rotational and linear motions. Determining an accurate mathematical model of the human vestibular system is significant for research pertaining to motion perception, as the quality and effectiveness of the motion cueing algorithm (MCA) directly depends on the mathematical model used in its design. This paper describes the history and analyses the development process of mathematical semicircular canal models. The aim of this review is to determine the most consistent and reliable mathematical semicircular canal models that agree with experimental results and theoretical analyses, and offer reliable approximations for the semicircular canal functions based on the existing studies. Selecting and formulating accurate mathematical models of semicircular canals are essential for implementation into the MCA and for ensuring effective human motion perception modeling.

  17. Association of obesity with serum leptin, adiponectin, and serotonin and gut microflora in beagle dogs. (United States)

    Park, H-J; Lee, S-E; Kim, H-B; Isaacson, R E; Seo, K-W; Song, K-H


    Serotonin (5-hydroxytryptamine, 5HT) is involved in hypothalamic regulation of energy consumption. Also, the gut microbiome can influence neuronal signaling to the brain through vagal afferent neurons. Therefore, serotonin concentrations in the central nervous system and the composition of the microbiota can be related to obesity. To examine adipokine, and, serotonin concentrations, and the gut microbiota in lean dogs and dogs with experimentally induced obesity. Fourteen healthy Beagle dogs were used in this study. Seven Beagle dogs in the obese group were fed commercial food ad libitum, over a period of 6 months to increase their weight and seven Beagle dogs in lean group were fed a restricted amount of the same diet to maintain optimal body condition over a period of 6 months. Peripheral leptin, adiponectin, 5HT, and cerebrospinal fluid (CSF-5HT) levels were measured by ELISA. Fecal samples were collected in lean and obese groups 6 months after obesity was induced. Targeted pyrosequencing of the 16S rRNA gene was performed using a Genome Sequencer FLX plus system. Leptin concentrations were higher in the obese group (1.98 ± 1.00) compared to those of the lean group (1.12 ± 0.07, P = .025). Adiponectin and 5-hydroytryptamine of cerebrospinal fluid (CSF-5HT) concentrations were higher in the lean group (27.1 ± 7.28) than in the obese group (14.4 ± 5.40, P = .018). Analysis of the microbiome revealed that the diversity of the microbial community was lower in the obese group. Microbes from the phylum Firmicutes (85%) were predominant group in the gut microbiota of lean dogs. However, bacteria from the phylum Proteobacteria (76%) were the predominant group in the gut microbiota of dogs in the obese group. Decreased 5HT levels in obese group might increase the risk of obesity because of increased appetite. Microflora enriched with gram-negative might be related with chronic inflammation status in obese dogs. Copyright © 2014 by the American College of Veterinary

  18. Ecohydrological features of some contrasting mires in Tierra del Fuego, Argentina

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    A. Grootjans


    Full Text Available In November 2005, Tierra del Fuego (Argentina hosted the biennial conference and field excursion of the International Mire Conservation Group (IMCG. The group considered the vegetation, hydrology, peat stratigraphy and possible management options for about 20 mires which were visited during a seven-day excursion. We report here some field observations and measurements of electrical conductivity (EC25 in five mires which have been selected to encompass the most important ecohydrological features of the mires of Tierra del Fuego. Existing and new data on landscape topography and vegetation were combined in three-dimensional drawings. These drawings are actually conceptual models which could underpin further ecohydrological research, and proved to be very useful as a basis for discussions amongst conference participants about possible ecohydrological relationships. The mires that were studied developed under a wide range of climatic conditions and included fens and bogs. The bogs typically developed from lakes or fens and most are now dominated by Sphagnum magellanicum. This species forms large hummocks, and can invade weakly-buffered fens. Most of the mires were well preserved, but effects of human impact - such as road building and peat extraction - were also noticeable.

  19. Epidemiological surveillance of cystic echinococcosis in rural population of Tierra del Fuego, Argentina, 1997-2006. (United States)

    Zanini, Fabián; Suárez, Carlos; Pérez, Héctor; Elissondo, María C


    Cystic echinococcosis (CE) is the most prevalent zoonosis in Tierra del Fuego. In 1997, ulrasonography (US) was selected as the method of choice for the development of population surveys for epidemiological surveillance and early diagnosis in rural population. The aim of this work was to present the results of the epidemiological surveillance of CE by means of US in rural population of Tierra del Fuego, Argentina between 1997 and 2006. The ultrasonographic diagnostic was realized once a year. The population was stratified in children (4 to 17 years) and adults. From each individual, name, age, sex, actual residence and origin were registered. The images compatible with cysts were graded according to location, number and characteristics. A total of 1400 rural inhabitants were examined for CE. From the total of studied individuals, 27 (1.9%) exhibited images compatible with cysts on the abdominal ultrasound scan. Thirteen of these persons were finally diagnosed as having CE. The overall prevalence of CE was 0.9%. This value is in accordance with the decrease in the prevalence observed in the definitive host and the intermediate hosts (sheep and cattle). The absence of cases in children during the studied period, evidence no transmission of the disease to humans in the recent past.


    Directory of Open Access Journals (Sweden)

    Andrea Coronato


    Full Text Available Se presentan evidencias geomorfológicas y palinológicas indicadoras de paleoescenarios existentes en los últimos dos millones de años en el extremo sur de Patagonia y Tierra del Fuego. Estos procesos indican la ocurrencia de cambios climáticos no forzados por intervención humana en la atmósfera. Los períodos fríos habrían sido progresivamente menos intensos desde la Gran Glaciación Patagónica, ocurrida hace 1 millón de años. Durante el Holoceno y los tiempos históricos, las glaciaciones se restringieron a las zonas superiores a los 900 m s.n.m. y el deterioro climático no habría afectado significativamente al ecosistema bosque ubicado a menos de 400 m s.n.m. Un importante período cálido ocurrido en tiempos históricos fue registrado en las zonas de altura en Patagonia Norte y en las cercanías al nivel del mar en Tierra del Fuego

  1. Los dilemas de la restitución de tierras en Colombia

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    Rodrigo Uprimny-Yepes


    Full Text Available El texto sostiene que si bien existen algunos encuentros estratégicos en el tema de tierras en distintos sectores de la sociedad, los cuales confluyen en el tema específico de la restitución, también existen diametrales desacuerdos sobre el tema. Por un lado, están quienes abogan por una “restitución fina”, y respaldan entonces una política de restitución que se concentre en corregir la ilegalidad del despojo y aclarar los títulos y los derechos individuales sobre los bienes, lo cual serviría para dinamizar el mercado de tierras y dar vía libre a una política de desarrollo rural que modernice la producción agraria, con base, esencialmente, en la gran propiedad empresarial. Al otro lado del espectro se ubican los defensores de lo que podemos llamar una “restitución gruesa”, quienes promueven la adopción de una política de restitución que satisfaga los objetivos no sólo de justicia correctiva, sino además de reconocimiento y redistribución a favor del campesinado y las comunidades étnicas.

  2. La industria textil en Tierra de Campos afines de la Edad Media

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    Hipólito Rafael OLIVA HERRER


    Full Text Available RESUMEN: El presente articulo trata de analizar el desarrollo de la industria textil rural en la región de Tierra de Campos, en torno al tradicional centro de producción textil de Palencia, a fines del XV y comienzos del XVI. La producción en el entorno rural conoció un amplio desarrollo basado en la producción de paños de calidad media-baja destinados al consumo interno, y dio lugar a formas organizativas complejas que se constituyeron en una alternativa frente al sistema gremial imperante en la urbe palentina, implicando intereses de un amplio espectro de grupos sociales.ABSTRACT: The present article aims to analyze the spreading of the rural textile industry in the region of Tierra de Campos in the late fifteenth and the early sixteenth centuries, around the traditional productive centre of Palencia. Here rural clothing experienced an important development based on the production of low and medium quality cloth under a putting-out system directed to interregional trade. The interests around rural industry involved a wide range of social groups, giving rise to complex organization forms and arising as an alternative to the traditional gudd stmcture.

  3. EVALUACIÓN DEL PATRIMONIO ARQUEOLÓGICO EN LA COSTA DEL LAGO FAGNANO, PARQUE NACIONAL TIERRA DEL FUEGO, ARGENTINA (Assessment of the Archaeological Heritage on the Coast of Lake Fagnano, Tierra del Fuego National Park, Argentina

    Directory of Open Access Journals (Sweden)

    María Celina Alvarez Soncini


    Full Text Available El presente trabajo se refiere a las prospecciones y análisis de materiales recuperados en la costa sur del lago Fagnano, dentro del Parque Nacional Tierra del Fuego, durante las campañas del año 2016. Los trabajos de campo permitieron efectuar un registro del patrimonio cultural del área prospectada, en la que se detectaron importantes evidencias arqueológicas. Los resultados de esta primera aproximación permiten ampliar nuestros conocimientos sobre la dinámica de ocupación humana en el área central de la Isla Grande de Tierra del Fuego, al incorporar una nueva zona en el tramo occidental del lago Fagnano. ENGLISH: This article presents the results of surveys and analysis of archaeological materials discovered on the southern coast of Lake Fagnano within the Tierra del Fuego National Park, during the 2016 field season. The fieldwork allowed us to register cultural heritage in the survey area in which important archaeological evidence was detected. The results of this first approach allow us to expand our knowledge about the dynamics of human occupation in the central region of the Great Island of Tierra del Fuego by incorporating a new zone in the western section of Lake Fagnano.

  4. The fluid mechanics of root canal irrigation. (United States)

    Gulabivala, K; Ng, Y-L; Gilbertson, M; Eames, I


    Root canal treatment is a common dental operation aimed at removing the contents of the geometrically complex canal chambers within teeth; its purpose is to remove diseased or infected tissue. The complex chamber is first enlarged and shaped by instruments to a size sufficient to deliver antibacterial fluids. These irrigants help to dissolve dying tissue, disinfect the canal walls and space and flush out debris. The effectiveness of the procedure is limited by access to the canal terminus. Endodontic research is focused on finding the instruments and clinical procedures that might improve success rates by more effectively reaching the apical anatomy. The individual factors affecting treatment outcome have not been unequivocally deciphered, partly because of the difficulty in isolating them and in making the link between simplified, general experimental models and the complex biological objects that are teeth. Explicitly considering the physical processes within the root canal can contribute to the resolution of these problems. The central problem is one of fluid motion in a confined geometry, which makes the dispersion and mixing of irrigant more difficult because of the absence of turbulence over much of the canal volume. The effects of treatments can be understood through the use of scale models, mathematical modelling and numerical computations. A particular concern in treatment is that caustic irrigant may penetrate beyond the root canal, causing chemical damage to the jawbone. In fact, a stagnation plane exists beyond the needle tip, which the irrigant cannot penetrate. The goal is therefore to shift the stagnation plane apically to be coincident with the canal terminus without extending beyond it. Needle design may solve some of the problems but the best design for irrigant penetration conflicts with that for optimal removal of the bacterial biofilm from the canal wall. Both irrigant penetration and biofilm removal may be improved through canal fluid

  5. The effect of cage size on play and aggression between dogs in purpose-bred beagles. (United States)

    Bebak, J; Beck, A M


    One intent of the proposed changes to USDA 9, CFR Part 3 was to give kennel dogs an opportunity for exercise and play (socialization). Increasing cage size was proposed as a means to encourage exercise and play, thus enhancing the well-being of kennel dogs. Eleven-month-old, female, purpose-bred Beagles, housed four to a cage, were videotaped for 15 hours on 10 different dates, resulting in five videotapes recorded for a smaller cage size and five videotapes recorded for a larger cage size. A total of 40 dogs were videotaped. For each videotape, aggression, play, and distance between dogs were recorded and analyzed. There were no differences in aggression or play, but the dogs did put significantly more distance between themselves in the larger cage.

  6. Effects of food intake on pharmacokinetics of mosapride in beagle dogs. (United States)

    Chae, J-W; Song, B-J; Baek, I-H; Yun, H-Y; Ma, J Y; Kwon, K-I


    This study was performed to determine the pharmacokinetic profile of mosapride in fasting and fed states. A single 5-mg oral dose of mosapride was administered to fasted (n = 15) and fed (n = 12) beagle dogs, and the plasma concentrations of mosapride were measured by liquid chromatography-tandem mass spectrometry. The resultant data were analyzed by noncompartmental analysis (NCA). Mosapride was absorbed in fasted and fed dogs with similar Tmax . Both Cmax and AUC were significantly higher in the fasting group than in fed dogs, being four times (10.51 μg/mL vs. 2.76 μg/mL) and 3.5 times higher (38.53 h · μg/mL vs. 10.22 h · μg/mL), respectively. These findings suggest that food intake affects the pharmacokinetics of mosapride and that the dosage regimen for this drug need to be reconsidered. © 2015 John Wiley & Sons Ltd.

  7. Biomarkers and heavy metal bioaccumulation in mussels transplanted to coastal waters of the Beagle Channel. (United States)

    Giarratano, Erica; Duarte, Claudia A; Amin, Oscar A


    Mussels coming from a mussel farm at Brown Bay (Beagle Channel) were transplanted to four sites inside Ushuaia Bay for 2 and 4 weeks. The objective of this study was to assess the quality of coastal waters of Ushuaia Bay by measuring catalase activity, lipid peroxidation, total lipid content, bioaccumulation of heavy metals and condition index in transplanted mussel Mytilus edulis chilensis. Biomarkers except condition index showed significant differences among exposure times as well as among tissues. Digestive gland presented the highest catalase activity, malondialdehyde level and total lipid content. Digestive gland also was the main target tissue of accumulation of iron and copper, while gill accumulated the highest levels of zinc. A principal component analyzes with the whole set of data allowed to separate stations based on physicochemical conditions and biochemical responses of each studied area. (c) 2009 Elsevier Inc. All rights reserved.

  8. A study on the mechanical properties of beagle femoral head using the digital speckle correlation method. (United States)

    Wang, Qinghua; Xie, Huimin; Tang, Peifu; Yao, Qi; Huang, Peng; Chen, Pengwan; Huang, Fenglei


    The mechanical properties of the femoral head are known to play an important role in the athletic performance of animals. In this paper, the full-field displacement and strain distributions of beagle femoral head samples in the U and V fields under loading were measured using the digital speckle correlation method (DSCM), and some deformation characteristics were analyzed. Young's modulus and Poisson's ratio were calculated to demonstrate the notable axial anisotropy of the femoral head. The axial compressive Young's modulus varies from 361MPa to 583MPa, and the transverse one is 213MPa. The Poisson's ratio in the axial-transverse direction ranges from 0.14 to 0.29, and the one in the transverse-axial direction is 0.07. Experimental results validated the accuracy of this measurement, providing a potential reference for investigating the deformation performance of the femoral head.

  9. Just before the Beagle: Charles Darwin's geological fieldwork in Wales, summer 1831. (United States)

    Roberts, M


    Darwin returned to Shrewsbury in mid-June 1831 and spent that summer learning geology. He made geological maps of Shropshire and visited Llanymynech and other localities. From 3-20th August he joined Sedgwick on his tour of North Wales; they geologised west of Shrewsbury before travelling through Llangollen, Ruthin, Conwy to Bangor finally reaching Anglesey. Darwin left Sedgwick at Menai and walked to Barmouth making a special visit of Cwm Idwal. He returned to Shrewsbury on 29th August to open the letter from Fitzroy inviting him to join the Beagle. During this summer Darwin gained skills in all aspects of geology, including chemical analysis, which were to prove vital in the development of his ideas on natural selection.

  10. Seasonal and pollution-induced variations in biomarkers of transplanted mussels within the Beagle Channel. (United States)

    Giarratano, Erica; Gil, Mónica N; Malanga, Gabriela


    The occurrence of biomarker variations linked to environmental factors makes it difficult to distinguish the effect of pollution. In an attempt to evaluate spatial and seasonal effects of environmental parameters on biomarker responses, mussels Mytilus edulis chilensis coming from an aquaculture farm were transplanted to several points within Ushuaia Bay (Beagle Channel) for 6 weeks in summer and winter. Activities of superoxide dismutase, catalase, glutathione-S-transferase and levels of lipid peroxidation were measured in gills and digestive gland. Cu, Zn, Fe, Cd and Pb concentrations were also assessed. Results indicated a significant effect of seasons on biological responses as well as in metal bioaccumulation showing the influence of natural factors such as dissolved oxygen, temperature and food availability. The interdependence of those environmental factors is important for the homeostasis of thermoconformers, especially regarding their oxidative metabolism and should also be taken into consideration to distinguish natural from pollution-induced variations. Copyright © 2011 Elsevier Ltd. All rights reserved.

  11. Effects of whole-body, ionizing radiation on the semen in beagle dogs

    Energy Technology Data Exchange (ETDEWEB)

    Day, P.A.


    Six beagle dogs were exposed to a total dose of 183 R of gamma radiation at a dose rate of 1 R/day, while three other dogs were exposed to a single dose of 100 R. Weekly semen analysis was performed on all irradiated dogs plus four nonirradiated dogs. Semen volume, sperm concentration, total sperm count, sperm motility and sperm head morphometry were examined. Dogs exposed to chronic radiation showed a severe decline in sperm numbers, detected after seven weeks of exposure. Sperm concentration and total sperm count were the first parameters affected and were the only parameters consistently affected. The dogs exposed to 100 R as a single dose, did not show a significant decline in sperm numbers. During a 36 week recovery period, the chronically irradiated dogs did show a slight increase in sperm numbers, but they never approached pre-exposure levels.

  12. Pharmacokinetic evaluation of Shenfu Injection in beagle dogs after intravenous drip administration

    Directory of Open Access Journals (Sweden)

    Yuqiao Zhang


    Full Text Available Shenfu Injection (SFI is a well-defined Chinese herbal formulation that is obtained from red ginseng and processed aconite root. The main active constituents in SFI are ginsenosides and aconitum alkaloids. In this work, ginsenosides (ginsenoside Rg1, ginsenoside Rb1 and ginsenoside Rc and aconitum alkaloids (benzoylmesaconine and fuziline were used as the index components to explore the pharmacokinetic behavior of SFI. A selective and sensitive HPLC–MS/MS method was developed for the quantification of ginsenosides and aconitum alkaloids in dog plasma and was used to characterize the pharmacokinetics of the five index components after intravenous drip of three different dosages of SFI in beagle dogs. The pharmacokinetic properties of the index components were linear over the dose range of 2–8 mL/kg.

  13. Lifetime tumor risk coefficients for beagle dogs that inhaled cerium-144 chloride

    Energy Technology Data Exchange (ETDEWEB)

    Boecker, B.B.; Hahn, F.F.; Griffith, W.C. [and others


    Reported here is one of the life-span radionuclide toxicology studies being conducted at ITRI in Beagle dogs. These studies are examining the life-span health risks of inhaled {Beta}-, {gamma}- and {alpha}-emitting radionuclides to expand available knowledge on these risks especially for the many cases for which human data are not available. The outcomes of these studies are providing important information on dosimetry and dose-response relationships for these inhaled radionuclides and the relative importance of a broad range of dose- and effect-modifying factors. A number of these studies are currently coming to completion. Much of the ITRI effort is being directed to final reviews of the dosimetric, clinical, and pathologic results and writing summary manuscripts. Radiation doses and effects in tissues adjacent to bone, specifically those of epithelial or marrow origin, should be considered when determining risks from internally deposited, bone-seeking radionuclides such as {sup 144}Ce.

  14. Biological effects of cesium-137 injected in beagle dogs of different ages

    Energy Technology Data Exchange (ETDEWEB)

    Nikula, K.J.; Muggenburg, B.A.; Griffith, W.C. [and others


    The toxicity of cesium-137 ({sup 137}Cs) in the Beagle dog was investigated at the Argonne National Laboratory (ANL) as part of a program to evaluate the biological effects of internally deposited radionuclides. The toxicity and health effects of {sup 137}Cs are important to understand because {sup 137}Cs is produced in large amounts in light-water nuclear reactors. Large quantities of cesium radioisotopes have entered the human food chain as a result of atmospheric nuclear weapons test, and additional cesium radioisotopes were released during the Chernobyl accident. Although the final analyses are not complete, three findings are significant: older dogs dies significantly earlier than juvenile and young adult dogs; greater occurrence of sarcomas in the cesium-137 injected dogs; the major nonneoplastic effect in dogs surviving beyond 52 d appears to be testicular atrophy.

  15. Use of cabergoline for oestrus induction in multiparous anoestrous Beagle bitches. (United States)

    Shimatsu, Y


    The purpose of this study was to examine the efficacy of daily cabergoline administration on oestrus induction in bitches. Of 20 multiparous Beagle bitches, 15 were not mated with sires in their last oestrus and 5 bitches that had been mated whelped. All bitches were in early or mid-anoestrus and received 5 μg/kg/day cabergoline PO. Oestrus was induced in the mid-anoestrus bitches at a higher rate than in the early anoestrus bitches. Comparing the different histories of previous pregnancy among the mid-anoestrus bitches, the rate of oestrus induction in the non-pregnant bitches was higher than in the bitches that whelped. Cabergoline is effective for oestrus induction in mid-anoestrus bitches. © 2017 Australian Veterinary Association.

  16. Pharmacokinetic studies of meloxicam following oral and transdermal administration in Beagle dogs (United States)

    Yuan, Yue; Chen, Xiao-yan; Li, San-ming; Wei, Xiu-yan; Yao, Hui-min; Zhong, Da-fang


    Aim: The potential for topical delivery of meloxicam was investigated by examining its pharmacokinetic profiles in plasma and synovial fluid following oral and transdermal administration in Beagle dogs. Methods: The experiment was a two-period, crossover design using 6 Beagle dogs. Meloxicam tablets were administered orally at a dose of 0.31 mg/kg, and meloxicam gel was administered transdermally at a dose of 1.25 mg/kg. Drug concentrations in plasma and synovial fluid were determined by liquid chromatography-tandem mass spectrometry (LC/MS/MS). The pharmacokinetic parameters were calculated using the Topfit 2.0 program. Results: The pharmacokinetic results showed that AUC0–t (23.9±8.26 μg.h.mL−1) in plasma after oral administration was significantly higher than after transdermal delivery (1.00±0.43 μg.h.mL−1). In contrast, the ratio of the average concentration in synovial fluid to that in plasma following transdermal administration was higher than that for an oral delivery. The synovial fluid concentration in the treated leg was much higher than that in the untreated leg, whereas the synovial fluid concentration in the untreated leg was similar to the plasma concentration. Conclusion: The high concentration ratio of synovial fluid to plasma indicates direct penetration of meloxicam following topical administration to the target tissue. This finding is further supported by the differences observed in meloxicam concentrations in synovial fluid in the treated and untreated joints at the same time point. Our results suggest that transdermal delivery of meloxicam is a promising method for decreasing its adverse systemic effects. PMID:19543299

  17. Reconstruction of beagle hemi-mandibular defects with allogenic mandibular scaffolds and autologous mesenchymal stem cells.

    Directory of Open Access Journals (Sweden)

    ChangKui Liu

    Full Text Available Massive bone allografts are frequently used in orthopedic reconstructive surgery, but carry a high failure rate of approximately 25%. We tested whether treatment of graft with mesenchymal stem cells (MSCs can increase the integration of massive allografts (hemi-mandible in a large animal model.Thirty beagle dogs received surgical left-sided hemi-mandibular defects, and then divided into two equal groups. Bony defects of the control group were reconstructed using allografts only. Those of the experimental group were reconstructed using allogenic mandibular scaffold-loaded autologous MSCs. Beagles from each group were killed at 4 (n = 4, 12 (n = 4, 24 (n = 4 or 48 weeks (n = 3 postoperatively. CT and micro-CT scans, histological analyses and the bone mineral density (BMD of transplants were used to evaluate defect reconstruction outcomes.Gross and CT examinations showed that the autologous bone grafts had healed in both groups. At 48 weeks, the allogenic mandibular scaffolds of the experimental group had been completely replaced by new bone, which has a smaller surface area to that of the original allogenic scaffold, whereas the scaffold in control dogs remained the same size as the original allogenic scaffold throughout. At 12 weeks, the BMD of the experimental group was significantly higher than the control group (p<0.05, and all micro-architectural parameters were significantly different between groups (p<0.05. Histological analyses showed almost all transplanted allogeneic bone was replaced by new bone, principally fibrous ossification, in the experimental group, which differed from the control group where little new bone formed.Our study demonstrated the feasibility of MSC-loaded allogenic mandibular scaffolds for the reconstruction of hemi-mandibular defects. Further studies are needed to test whether these results can be surpassed by the use of allogenic mandibular scaffolds loaded with a combination of MSCs and osteoinductive growth

  18. Osteoporotic-like effects of cadmium on bone mineral density and content in aged ovariectomized beagles

    Energy Technology Data Exchange (ETDEWEB)

    Sacco-Gibson, N.; Abrams, J.; Chaudhry, S.; Hurst, D.; Peterson, D.; Bhattacharyya, M.


    Our purpose was to evaluate the effects of ovariectomy in conjunction with cadmium (Cd) exposure on bone. Aged female beagles with {sup 45}Ca-labeled skeletons ovariectomized and exposed to Cd. Successive vertebral scans by dual photon absorptiometry monitored changes in bone mineral density (BMD) in each dog with time. Results showed that ovariectomy or Cd exposure alone caused significant decreases in BMD; ovariectomy with Cd exposure caused the greatest decrease. Ovariectomy alone did not decrease BMD in the distal end or mid-shaft of the tibia while BMD of the distal tibia decreased significantly due to Cd exposure alone. Combination treatment resulted in significant decreases in BMD of both tibial regions. At necropsy, tibiae, humeri, lumbar vertebrae and ribs were obtained for biochemical analysis. No group-to-group differences in bone weights (wet, dry, ash), in ash/dry ratios, or in long bone and vertebral Ca/dry or Ca/ash ratios were observed. Significantly higher total {sup 45}Ca content and {sup 45}Ca/dry and {sup 45}Ca/ash ratios were observed in long bones and vertebrae of OV- and OV+ groups. In contrast, intact ribs showed significantly decreased Ca/dry and Ca/ash ratios compared to the SO-group. Quartered ribs demonstrated regional responses to specific treatment; decreases in total Ca content were greatest in the mid-rib region ({minus}36 to {minus}46%). Results suggest that in the aged female beagle, bone mineral loss associated with estrogen depletion is not only related to bone type (trabecular versus cortical) but also to bone Ca pools. Our results also suggest that a regional heterogeneity of bone plays a role in responsiveness to ovariectomy and Cd exposure. These aspects suggest that Cd is an exogenous factor affecting bone mineral loss independently of estrogen depletion. However, estrogen depletion primes bone for responsiveness to Cd-induced bone mineral loss.

  19. [Quantitative analysis of nFA/PEEK implant interfaces in Beagle dogs]. (United States)

    Li, Ling-yu; Zhou, Cong-ying; Wei, Jie; Ma, Jian


    A new synthetic nano-fluorapatite poly-ether-ether-ketone (nFA/PEEK) dental implant in screw type was developed and its biocompatibility and osseointegration ability were evaluated in Beagle dogs. Ten sandblasted and 10 non-sandblasted nFA/PEEK implants were placed in 6 adult Beagle dogs and the bilateral mandibular second and third premolar was extracted and the wounds were healed over 3 months. Three dogs were randomly chosen and executed at the end of 8th and 12th week. To evaluated bone to implant contact(BIC) and mineral apposition rate(MAR), tetracycline was intramuscularly given twice at 10th and 3rd day, before sacrifice respectively. The implants and the surrounding bone as a whole were collected and examined by synchrotron radiation tomography. Undecalcified implant and bone specimens were cut and stained by Van Gieson for a static histomorphometric analysis. The data was analyzed using SPSS18.0 software package. The implants were demonstrated by synchrotron radiation and connected to most of their bone beds at 8th week. Some new bones were developed into threads of screw implants, while complete osseointegration were noted at 12th week. Sandblasted implants were found to be faster matured. BIC and MAR of sandblasted group (63.34%, 1.51 μm/d) were significantly higher than that of non-sandblasted group (22.97%, 1.34 μm/d) (P0.05). The sandblasting group was more conductive to increase their bone mass. Sandblasted synthetic polymer's biomaterial nFA/PEEK has excellent biocompatibility and osteogenic properties, which is better osseointegrated to its bone bed. It will be a promising material as dental implants in the future.

  20. Posterior semicircular canal dehiscence: a morphologic cause of vertigo similar to superior semicircular canal dehiscence

    Energy Technology Data Exchange (ETDEWEB)

    Krombach, G.A.; Schmitz-Rode, T.; Haage, P.; Guenther, R.W. [Department of Diagnostic Radiology, University of Technology, Pauwelstrasse 30, 52057, Aachen (Germany); DiMartino, E. [Department of Otorhinolaryngology, University of Technology, Pauwelstrasse 30, 52057, Aachen (Germany); Prescher, A. [Department of Anatomy, University of Technology, Pauwelstrasse 30, 52057, Aachen (Germany); Kinzel, S. [Department of Experimental Veterinarian Medicine, University of Technology, Pauwelstrasse 30, 52057, Aachen (Germany)


    Heading Abstract.The aim of this study was to assess imaging findings of posterior semicircular dehiscence on computed tomography and to evaluate incidence of posterior and superior semicircular canal dehiscence in patients presenting with vertigo, sensorineuronal hearing loss or in a control group without symptoms related to the inner ear. Computed tomography was performed in 507 patients presenting either with vertigo (n=128; 23 of these patients suffered also from sensorineuronal hearing loss), other symptoms related to the inner ear, such as hearing loss or tinnitus (n=183) or symptoms unrelated to the labyrinth (n=196). All images were reviewed for presence of dehiscence of the bone, overlying the semicircular canals. Twenty-nine patients had superior semicircular canal dehiscence. Of these patients, 83% presented with vertigo, 10% with hearing loss or tinnitus and the remaining 7% with symptoms unrelated to the inner ear. In 23 patients dehiscence of the posterior semicircular canal was encountered. Of these patients, 86% presented with vertigo, 9% with hearing loss or tinnitus and 5% with symptoms unrelated to the inner ear. Defects of the bony overly are found at the posterior semicircular canal, in addition to the recently introduced superior canal dehiscence syndrome. Significant prevalence of vertigo in these patients suggests that posterior semicircular canal dehiscence can cause vertigo, similar to superior semicircular canal dehiscence. (orig.)


    National Research Council Canada - National Science Library

    Joaquín Bascopé Julio


    ..., de otros pasajeros, que desviaron o detuvieron, al menos parcialmente, los engranajes de la máquina estanciera. PALABRAS CLAVE: Historia estanciera, biopolítica, nomadismo obrero. PASSENGERS OF LANDOWNER'S POWER. THE SOCIEDAD EXPLOTADORA DE TIERRA DEL FUEGO AND ESTANCIA'S BIOPOLITICS (1890-1920) ABSTRACT In the early 20th century the Patagonian sheep-farming busine...

  2. A la zaga de lo politico. La agenda mediatica de la Ley de Victimas y Restitucion de Tierras

    National Research Council Canada - National Science Library

    Velez Lopez, Ana Cristina


    ... en la inequidad social y en la tenencia de la tierra. En el curso de la aprobacion de la Ley, y desde el campo de la comunicacion politica, no solo el gobierno es actor, lo son tambien los opositores, las victimas y los medios...

  3. Acaparamiento de tierras y acumulación global capitalista: aspectos clave en América Latina.

    Directory of Open Access Journals (Sweden)

    Natalia Landivar


    Full Text Available El número especial de la Canadian  Journal  of Develop-ment Studies aporta con nuevos elementos para entender el fenómeno del acaparamiento de tierras. Basado en estudios empíricos de expertos de siete países de AméricaLatina.

  4. Modelo matemático para la descripción de la transferencia de calor para tierra vertida

    Directory of Open Access Journals (Sweden)

    Edgardo Jonathan Suárez-Domínguez


    Full Text Available La arquitectura de tierra implica procesos constructivos sustentables ya que utiliza materiales vernáculos duraderos cuyos residuos son de bajo impacto al ambiente. La tierra vertida es una técnica a partir de la cual pueden tenerse muros resistentes dentro de la edificación de viviendas pero cuyas propiedades han sido poco evaluadas y representadas a partir de modelos. La transferencia de calor es una de las características más importantes cuando se edifica en zonas calurosas pues implica ciertos niveles de confort para los usuarios. El presente trabajo propone un modelo para determinar la difusividad térmica de tierra vertida con uso potencial para otras determinaciones a diversas temperaturas, algunas implicaciones también son presentadas. Se encontró que el coeficiente de difusividad térmica de muestras de tierra vertida fue de   4.319  10 8 m 2 s 1 , mientras que su calor específico es de 1.1030 kJkg-1K 1 .

  5. Familia nuclear y jefatura del hogar: acceso a la mujer a la tierra en las reformas agrarias

    Directory of Open Access Journals (Sweden)

    Magdalena León


    Full Text Available En este texto se analizan las consecuencias que la neutralidad de género ha dejado para la política pública, en el caso específico de las reformas agrarias y acceso de la mujer a la tierra en América Latina.

  6. Taenia saginata Goeze, 1872 (Platyhelminthes: Cestoda: Taeniidae en un indígena de Tierra del Fuego, Chile

    Directory of Open Access Journals (Sweden)

    Eduardo I. Faúndez


    Full Text Available Se entrega el primer registro del céstodo Taenia saginata en un indígena de Tierra del Fuego (Patagonia chilena, correspondiente al año 1902. Se discute la importancia del registro y se entregan ilustraciones del ejemplar.

  7. El Hidróxido de Calcio y los bloques de tierra comprimida, alternativa sostenible de construcción

    National Research Council Canada - National Science Library

    Rubén Salvador Roux Gutiérrez; José Adán Espuna Mujica


    ... del hidróxido de cal y los bl oques de tierra comprimida (BTC), para la edificación de vivienda y así poder reducir las emisones de CO 2 emitidas por los procesos constructivos convenci o nales El presente...

  8. Comer tierra

    Directory of Open Access Journals (Sweden)

    Darío Achury Valenzuela


    Full Text Available Los hombres de ciencia, singularmente los médicos, que han tratado de la geofagia, no han logrado ponerse de acuerdo en la determinación de sus causas proximas o remotas. Opinan unos que se trata sencillamente de un recurso terapéutico, en órden a la curación de ciertas dolencias, al cual apelaban, por ejemplo, algunos habitantes de ciertas provincias de Francia para tratar la forunculósis, los ántrax y el cólera asiático, y también los indios del Perú para curar las hemorroides, la gota coral, la diarrea y cierta clase de llagas rebeldes, como luego se verá más a espacio.

  9. Revestimientos y acabados superficiales en construcciones con tierra contemporáneas

    Directory of Open Access Journals (Sweden)

    Castilla, F. J.


    Full Text Available Earth construction is in increasing demand in some areas of building activity, which means a need for technical solutions to maintain and preserve the properties of earth walls. Like earth wall construction techniques themselves, materials used for rendering (plastering, painting, panelling, etc have evolved in a way that allows us to find formal solutions suitable for every architectural situation. This paper deals with the special features of each rendering technique available in contemporary construction, from renderings permitting earth wall textures and finish to be appreciated, to plasters from different materials. Special attention will be focused on clay plasters, which are more appreciated due to its natural characteristics and compatibility with the base wall. The explanations are supported by different examples of buildings where these techniques have been used during the last two decades.

    La creciente demanda para la construcción de muros de tierra en algunos ámbitos del sector de la edificación conlleva la necesidad de plantear soluciones constructivas que permitan el adecuado mantenimiento de las prestaciones de dichos muros. Al igual que las propias técnicas para la construcción de los muros, los materiales utilizados para su revestimiento y protección han evolucionado permitiendo una gran variedad de soluciones formales acordes a cada situación. En este artículo se pretende hacer una revisión sobre las particularidades de las diferentes posibilidades que se presentan en el panorama de la construcción actual: desde los revestimientos que permitan mantener a la vista los acabados de los muros de tierra a los revocos de distinta naturaleza, con especial incidencia en aquellos que utilizan la propia tierra como material base, siendo los más apropiados a priori por su natural compatibilidad con el soporte. La explicación se acompañará de ejemplos ilustrativos de la aplicación de dichas técnicas en edificios

  10. La tierra en armas de Dávalos-Serrano (o las armas del teatro

    Directory of Open Access Journals (Sweden)

    Marcela Beatriz Sosa


    Full Text Available La tierra en armas (1926 constituye un texto enigmático por diversas cuestiones, a pesar de su celebridad –es la obra teatral más famosa de la literatura salteña- y de su aparente transparencia al representar hechos históricos relativos a la gesta de Güemes. El primer enigma es el problema de la autoría, ya que La tierra en armas surge de la escritura en colaboración de Juan Carlos Dávalos y Ramón Serrano, pero en el momento de publicación del texto (1935 aparecerá en la portada sólo el nombre de Dávalos. El gesto editorial de borrar el nombre del segundo autor en esa primera publicación es decisivo para el futuro teatral de Serrano, quien desaparece posteriormente de la escena salteña. La segunda cuestión deriva de la categoría de teatro histórico a la cual pertenece La tierra en armas La ficcionalización de un personaje histórico implica plantear las complejas relaciones que se establecen entre discurso dramático y discurso histórico. Luego de trazar someramente la trayectoria épica de Güemes, se realiza una descripción de la acción dramática y de los fundamentales procedimientos discursivos, como el encadenamiento entre la intriga principal (histórica y la secundaria (sentimental, la mise en abyme de la leyenda de la flor del Ilolay y la visualización escénica del texto. La tercera cuestión incluye el contexto de producción, circulación y recepción del teatro de la época, así como el nivel ideológico, sin los cuales sería imposible postular una interpretación del texto de Dávalos y Serrano como estrategia individual y colectiva de afianzamiento de la identidad.

  11. Management of C-shaped canals: Two case reports

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    Nilesh Suryakant Kadam


    Full Text Available A C-shaped canal with varying configuration is commonly observed in single-rooted mandibular second molars. Cooke and Cox (1979 first documented the C-shaped canal in endodontic literature. The presence of high incidence of transverse anastomoses, lateral canals, and apical deltas makes it difficult to clean and seal the root canal system in these teeth. The main reason for failure in endodontic treatment of mandibular second molars is the inability to detect the presence of C-shaped canals prior to an endodontic therapy. This case report presents successful management of two rare cases of C-shaped canal configurations.

  12. Function of lateral line canal morphology. (United States)

    Klein, Adrian; Bleckmann, Horst


    Fish perceive water motions and pressure gradients with their lateral line. Lateral line information is used for prey detection, spatial orientation, predator avoidance, schooling behavior, intraspecific communication and station holding. The lateral line of most fishes consists of superficial neuromasts (SNs) and canal neuromasts (CNs). The distribution of SNs and CNs shows a high degree of variation among fishes. Researchers have speculated for decades about the functional significance of this diversity, often without any conclusive answers. Klein et al. (2013) examined how tubules, pore number and pore patterns affect the filter properties of lateral line canals in a marine teleost, the black prickleback (Xiphister atropurpureus). A preliminary mathematical model was formulated and biomimetic sensors were built. For the present study the mathematical model was extended to understand the major underlying principle of how canal dimensions influence the filter properties of the lateral line. Both the extended mathematical model and the sensor experiments show that the number and distribution of pores determine the spatial filter properties of the lateral line. In an environment with little hydrodynamic noise, simple and complex lateral line canals have comparable response properties. However, if exposed to highly turbulent conditions, canals with numerous widely spaced pores increase the signal to noise ratio significantly. © 2014 International Society of Zoological Sciences, Institute of Zoology/Chinese Academy of Sciences and Wiley Publishing Asia Pty Ltd.

  13. Effects of a tetracycline blended polylactic and polyglycolic acid membrane on the healing of one-wall intrabony defects in beagle dogs

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Il-Young [Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-752l (Korea, Republic of); Jung, Ui-Won [Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-752l (Korea, Republic of); Kim, Chang-Sung [Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-752l (Korea, Republic of); Lee, Yong-Keun [Department and Research Institute of Dental Biomaterials and Bioengineering, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-750 (Korea, Republic of); Cho, Kyoo-Sung [Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-752l (Korea, Republic of); Chai, Jung-Kiu [Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-752l (Korea, Republic of); Kim, Chong-Kwan [Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-752l (Korea, Republic of); Choi, Seong-Ho [Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-752l (Korea, Republic of)


    The purpose of this study was to evaluate the regenerative effects of a tetracycline blended polylactic and polyglycolic acid (TC-PLGA) and non-blended polylactic and polyglycolic acid (PLGA) barrier membrane on one-wall intrabony defects in beagle dogs. It can be concluded that when used for guided tissue regeneration TC-PLGA membranes show a beneficial effect on one-wall intrabony defects in beagle dogs.

  14. Quaternary molluscan faunas from the island of Tierra del Fuego after the Last Glacial Maximum

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    Sandra Gordillo


    Full Text Available Palaeontological studies on postglacial molluscan faunas from marine deposits located along the northern coast of the Beagle Channel (lat. 54°55’S, long. 68°34’-67°11’W showed differences of various molluscan assemblages during a period of climatic stability after deglaciation. Oceanographic changes, different local environmental conditions and/or episodes of minor climatic fluctuations are pointed out as causes for the variations in faunal composition. Comparison with Quaternary molluscs from Antarctica showed that these palaeofaunas overlap slightly at the species level, but have a considerable number of genera (23% and families (50% in common. These affinities and relationships are better explained on the basis of more recent migrating taxa than by ancient connections when the two regions formed part of the Weddellian Province.

  15. Study of root canal accessibility in human primary molars. (United States)

    Aminabadi, Naser A; Farahani, Ramin M Z; Gajan, Esrafil B


    The aim of the present study was to provide a general scheme for pulpectomy of primary molars that may be useful for decision-making about negotiation of root canals and selection of appropriate instruments. A total of 160 vital primary molars in 85 patients (40 males, 45 females) aged 4-6 years were selected. After taking primary radiographs, local anesthesia was induced, and the teeth were isolated using a rubber dam. Canal accessibility index (CAI) and tooth accessibility index (TAI) were calculated according to initial file size. Mandibular first molars had either three canals (79.2%) or four canals (20.8%), and all second molars had four canals. Maxillary first molars had three canals and second molars had either three canals (70.9%) or four canals (29.1%). Lower accessibility of the mandibular first molar distobuccal root accounted for the lower accessibility of these teeth in comparison with mandibular second molars. While three-canal maxillary second molars were more accessible due to the lower accessibility of the distobuccal canal of the maxillary first molar, poor accessibility of the distal canal in four-canal second molars was responsible for the difficult accessibility of these teeth. In conclusion, it seems that the accessibility of a single canal in each tooth determines the difficulty of accessibility for any given tooth. Moreover, while primary second molars are more accessible than first molars, all of them are negotiable.

  16. Root canal debridement: an online study guide. (United States)


    The Editorial Board of the Journal of Endodontics has developed a literature-based study guide of topical areas related to endodontics. This study guide is intended to give the reader a focused review of the essential endodontic literature and does not cite all possible articles related to each topic. Although citing all articles would be comprehensive, it would defeat the idea of a study guide. This section will present root canal debridement including subdivisions on canal access, canal debridement, orifice enlargement and preflaring, crown-down technique, balanced force, nickel titanium and other shape memory alloys, rotary engine-driven techniques, endodontic instruments, irrigation, electronic apex locators, sonics/ultrasonics, smear layer, and intracanal medicaments.

  17. Problemas ambientales detectados por la población de Ushuaia (Tierra del Fuego, Argentina

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    María Gabriela Orzanco


    Full Text Available This paper focuses on the inhabitant´s image of Ushuaia city. The study was approached through a social-economic stratification. Ushuaia, capital city of Tierra del Fuego province, is located in a biological and physical constrained environment and shows many environmental problems as a result of an intensive increase of population in the last 15 years. The image of the city was constructed from general and environmental problems and local resources to be preserved as mentioned by people, and was obtained from 114 questionnaires analized through frequence and principal component analysis. Results showed differents images of the city and relationship among nature of mentioned problems and occupational classes and educational level prevailing in each zone.

  18. Parábola existencial de la primera Residencia en la Tierra

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    Eduardo Gómez


    Full Text Available Como sucede con muchos artistas, es el amor el que hace de Neruda un gran poeta. Su iniciación en la literatura universal data, sin duda, de los "Veinte poemas de amor y una canción desesperada" pero es a partír de "Residencia en la tierra" que logra afianzarse, en profundidad, como uno de los grandes poetas de la lengua castellana y uno de los más extraordinarios líricos de la historia de la literatura. En "Veinte poemas... ", el amor lo hace compenetrarse, estremecido, con la Naturaleza, lo desnuda de convenciones y prejuicios, lo embriaga de gozos dolorosos y le descubre todo el vasto mundo popular del drama sentim ental, depurado y abierto a la profundidad cósmica.

  19. Substations grounding systems design; Diseno de sistemas de conexion a tierra en subestaciones

    Energy Technology Data Exchange (ETDEWEB)

    Velazquez Sanchez, Raul [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)


    The grounding systems have been the object of a great number of analytical and experimental studies in the past 15 years, that have given rise to research reports on the several aspects involved in this technique. In this work are briefly reviewed various aspects that is necessary to take into account for its design, analysis and put in operation. [Espanol] Los sistemas de conexion a tierra han sido objeto de gran cantidad de estudios analiticos y experimentales en los pasados quince anos, que han dado origen a informes de investigacion sobre los diversos aspectos que involucra esta tecnica. En este trabajo se revisan brevemente diversos aspectos que es necesario considerar para su diseno, analisis y puesta en operacion.

  20. Crecimiento de Colossoma macropomum en estanques de tierra en dependencia de la densidad.

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    Jorge Günther


    Full Text Available Se analiza el crecimiento y la utilización de alimento del tambaquí, Colossoma macropomum, cultivado a densidades de 0,5, 1 y 2 peces/m2 en estanques de tierra de 60m2 con alimento balanceado con 35% proteína. No se encontraron diferencias estadísticas significativas con respecto a la densidad. Sin embargo, el crecimiento obtenido fue mucho menor que en otro ensayo realizado en las mismas condiciones y simultáneamente en un estanque de 3000 m2, por lo que se discute la hipótesis de que el crecimiento del tambaquí esté relacionado con el tamaño del estanque.

  1. La tierra entre derecho y cultura indígena en Argentina

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    Marzia Rosti


    Full Text Available The paper considers the relationships between the indigenous peoples and the Argentinian State since the XIX century until 1994, when it was introduced in the Constitution the provision acknowledging to the indigenous peoples “la posesión y propiedad comunitarias de las tierras que tradicionalmente ocupan”, “la entrega de otras aptas y suficientes para el desarrollo humano” and granting them “la parcipación en la gestión referida a sus recursos naturales y a los demás intereses que los afecten” (art. 75, inc. 17. The paper describes then the issue concerning the claim for indigenous land – raised by the new constitutional provision – and focuses on some significant cases and the more recent jurisprudence on that issue.

  2. Una version manuscrita del romance "Yo salí de la mi tierra"

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    Full Text Available En el manuscrito 327 die la Biblioteca de Cataluña, en Barcelona, figura el romance de las Querellas de Alfonso el Sabio, que empieza por "Yo salí de la mi tierra", singular composiuión muy conocida dentlro del romancero alfonsino, Publico la versión que del poema nos ofrece el manuscrito con la única finalidad de añadir una versión más a las ya publicadas. Al final de este trabajo transcribiré, además, tres fragmentos del mismo manuscrito, que considlero inédito, referentes a tres episodios de la historia legendaria de aquel rey, posiblemente tomados, como el romance, de alguna miscelánea, síntesis o sumario de carácter histórico del siglo XVI, cuyo colector debió tener presente la Cuarta Crónica general.

  3. Speckle Interferometry of Four Close Binaries: First Results of the Tierra Astronomical Institute Telescope (United States)

    Wasson, Rick; Goldbaum, Jesse; Boyce, Pat; Harwell, Robert; Hillburn, Jerry; Rowe, Dave; Sadjadi, Sina; Westergren, Donald; Genet, Russell


    This paper documents first use for speckle interferometry of the Tierra Astronomical Institute’s 24-inch telescope, located at Terra Del Sol, some 60-miles east of San Diego, CA. Measurements are reported for four close binary systems - STF2173AB, D15, STF2205, and HSD2685 - observed over the weekend of July 1-3, 2016. The objectives of this engineering checkout run were to evaluate the integration of the telescope and ZWO ASI 290MM high speed CMOS camera, and to establish observational procedures for future speckle observations, including those made with advanced high school and college student researchers. Difficulties encountered in the checkout are described, along with suggestions for overcoming them in the next run.

  4. Atmospheric electric discharges and grounding systems; Descargas atmosfericas y sistemas de conexion a tierra

    Energy Technology Data Exchange (ETDEWEB)

    Rivas, Elena [ed.] [Instituto de Investigaciones Electricas, Temixco, Morelos (Mexico)


    In this article the work made by the Institute of Investigaciones Electricas (IIE), in the area of atmospheric electric discharges and grounding connections at Comision Federal de Electricidad (CFE) is presented. The work consisted of the revision of the procedures for the design of transmission lines and substations of CFE from which high indexes of interruptions are reported, from this, a program was defined that allowed to improve the existing designs in CFE. [Spanish] En este articulo se presenta el trabajo realizado por el Instituto de Investigaciones Electricas (IIE), en el area de descargas atmosfericas y conexiones a tierra en Comision Federal de Electricidad (CFE). El trabajo consistio en la revision de los procedimientos de diseno de las areas de transmision y subestaciones de la CFE para los que se reportan altos indices de salidas, a partir de esto se definio un programa que permitio mejorar los disenos existentes en la CFE.

  5. El regreso de los judíos hispanos a Tierra Santa

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    Enrique Cantera Montenegro


    Full Text Available Tras un breve análisis acerca del lugar que la ciudad de Jerusalén y la Tierra Prometida ocupan en el judaismo y en la conciencia colectiva del pueblo judío, y del papel que la Ciudad Santa desempeña como meta de los peregrinos judíos, se estudian los movimientos de migración de los judíos hispanos hacia Palestina, a lo largo de la Edad Media y hasta el siglo XVII.After a brief analysis about the importance of Jerusalem and the Promised Land in the Judaism and in the collective consciousness of the Jewish people, and the role played by the Holy City as a destination for the Jewish pilgrims, the migration movements of the Spanish Jewish to Palestine are studied, along the Middle Ages, until the 17th century.

  6. ¿adónde va a caer este globo? acerca del futuro de la tierra


    Mesa Sánchez, Óscar José


    Por considerarlo de la mayor relevancia, en esta edición reproducimos el capítulo de Introducción del libro “¿Adónde va a caer este globo? Acerca del futuro de la Tierraâ€�, del Profesor Óscar José Mesa Sánchez, y seguidamente publicamos la reseña del mismo libro, escrita por el Profesor Darío Valencia Restrepo, y publicada en el periódico El Mundo de Medellín. Agradecemos a los Profesores Mesa Sánchez y Valencia Restrepo por su colaboración con la revista. Germán Poveda Jaramillo Di...

  7. TIERRAS: A package to simulate high energy cosmic ray showers underground, underwater and under-ice (United States)

    Tueros, Matías; Sciutto, Sergio


    In this paper we present TIERRAS, a Monte Carlo simulation program based on the well-known AIRES air shower simulations system that enables the propagation of particle cascades underground, providing a tool to study particles arriving underground from a primary cosmic ray on the atmosphere or to initiate cascades directly underground and propagate them, exiting into the atmosphere if necessary. We show several cross-checks of its results against CORSIKA, FLUKA, GEANT and ZHS simulations and we make some considerations regarding its possible use and limitations. The first results of full underground shower simulations are presented, as an example of the package capabilities. Program summaryProgram title: TIERRAS for AIRES Catalogue identifier: AEFO_v1_0 Program summary URL: Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, No. of lines in distributed program, including test data, etc.: 36 489 No. of bytes in distributed program, including test data, etc.: 3 261 669 Distribution format: tar.gz Programming language: Fortran 77 and C Computer: PC, Alpha, IBM, HP, Silicon Graphics and Sun workstations Operating system: Linux, DEC Unix, AIX, SunOS, Unix System V RAM: 22 Mb bytes Classification: 1.1 External routines: TIERRAS requires AIRES 2.8.4 to be installed on the system. AIRES 2.8.4 can be downloaded from Nature of problem: Simulation of high and ultra high energy underground particle showers. Solution method: Modification of the AIRES 2.8.4 code to accommodate underground conditions. Restrictions: In AIRES some processes that are not statistically significant on the atmosphere are not simulated. In particular, it does not include muon photonuclear processes. This imposes a limitation on the application of this package to a depth of


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    Jorge Olcina Cantos


    Full Text Available La actividad agraria es el sector económico que, con mayor frecuencia, sufre los efectos de episodios atmosféricos excepcionales que ocasionan graves pérdi- das de cosecha y daños en campos de cultivo e infraestructura agraria (caminos, redes de riego. El campo valenciano no es ajeno a estos eventos, por lo demás condignos a sus condiciones climáticas (lluvias torrenciales, heladas, tormentas de granizo, temporales de viento y sequías, que precisan estudio de causas, consecuencias económicas y localización territorial de sectores de riesgo, para la posterior propuesta de medidas de actuación. La relación de prácticas de defensa puestas en práctica en tierras valencianas ante estos sucesos atmosféri- cos completa el presente estudio.

  9. Bryophyte-cyanobacteria associations during primary succession in recently Deglaciated areas of Tierra del Fuego (Chile.

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    María Arróniz-Crespo

    Full Text Available Bryophyte establishment represents a positive feedback process that enhances soil development in newly exposed terrain. Further, biological nitrogen (N fixation by cyanobacteria in association with mosses can be an important supply of N to terrestrial ecosystems, however the role of these associations during post-glacial primary succession is not yet fully understood. Here, we analyzed chronosequences in front of two receding glaciers with contrasting climatic conditions (wetter vs drier at Cordillera Darwin (Tierra del Fuego and found that most mosses had the capacity to support an epiphytic flora of cyanobacteria and exhibited high rates of N2 fixation. Pioneer moss-cyanobacteria associations showed the highest N2 fixation rates (4.60 and 4.96 µg N g-1 bryo. d-1 very early after glacier retreat (4 and 7 years which may help accelerate soil development under wetter conditions. In drier climate, N2 fixation on bryophyte-cyanobacteria associations was also high (0.94 and 1.42 µg N g-1 bryo. d-1 but peaked at intermediate-aged sites (26 and 66 years. N2 fixation capacity on bryophytes was primarily driven by epiphytic cyanobacteria abundance rather than community composition. Most liverworts showed low colonization and N2 fixation rates, and mosses did not exhibit consistent differences across life forms and habitat (saxicolous vs terricolous. We also found a clear relationship between cyanobacteria genera and the stages of ecological succession, but no relationship was found with host species identity. Glacier forelands in Tierra del Fuego show fast rates of soil transformation which imply large quantities of N inputs. Our results highlight the potential contribution of bryophyte-cyanobacteria associations to N accumulation during post-glacial primary succession and further describe the factors that drive N2-fixation rates in post-glacial areas with very low N deposition.

  10. Bryophyte-cyanobacteria associations during primary succession in recently Deglaciated areas of Tierra del Fuego (Chile). (United States)

    Arróniz-Crespo, María; Pérez-Ortega, Sergio; De Los Ríos, Asunción; Green, T G Allan; Ochoa-Hueso, Raúl; Casermeiro, Miguel Ángel; de la Cruz, María Teresa; Pintado, Ana; Palacios, David; Rozzi, Ricardo; Tysklind, Niklas; Sancho, Leopoldo G


    Bryophyte establishment represents a positive feedback process that enhances soil development in newly exposed terrain. Further, biological nitrogen (N) fixation by cyanobacteria in association with mosses can be an important supply of N to terrestrial ecosystems, however the role of these associations during post-glacial primary succession is not yet fully understood. Here, we analyzed chronosequences in front of two receding glaciers with contrasting climatic conditions (wetter vs drier) at Cordillera Darwin (Tierra del Fuego) and found that most mosses had the capacity to support an epiphytic flora of cyanobacteria and exhibited high rates of N2 fixation. Pioneer moss-cyanobacteria associations showed the highest N2 fixation rates (4.60 and 4.96 µg N g-1 bryo. d-1) very early after glacier retreat (4 and 7 years) which may help accelerate soil development under wetter conditions. In drier climate, N2 fixation on bryophyte-cyanobacteria associations was also high (0.94 and 1.42 µg N g-1 bryo. d-1) but peaked at intermediate-aged sites (26 and 66 years). N2 fixation capacity on bryophytes was primarily driven by epiphytic cyanobacteria abundance rather than community composition. Most liverworts showed low colonization and N2 fixation rates, and mosses did not exhibit consistent differences across life forms and habitat (saxicolous vs terricolous). We also found a clear relationship between cyanobacteria genera and the stages of ecological succession, but no relationship was found with host species identity. Glacier forelands in Tierra del Fuego show fast rates of soil transformation which imply large quantities of N inputs. Our results highlight the potential contribution of bryophyte-cyanobacteria associations to N accumulation during post-glacial primary succession and further describe the factors that drive N2-fixation rates in post-glacial areas with very low N deposition.

  11. Bryophyte-Cyanobacteria Associations during Primary Succession in Recently Deglaciated Areas of Tierra del Fuego (Chile) (United States)

    Arróniz-Crespo, María; Pérez-Ortega, Sergio; De los Ríos, Asunción; Green, T. G. Allan; Ochoa-Hueso, Raúl; Casermeiro, Miguel Ángel; de la Cruz, María Teresa; Pintado, Ana; Palacios, David; Rozzi, Ricardo; Tysklind, Niklas; Sancho, Leopoldo G.


    Bryophyte establishment represents a positive feedback process that enhances soil development in newly exposed terrain. Further, biological nitrogen (N) fixation by cyanobacteria in association with mosses can be an important supply of N to terrestrial ecosystems, however the role of these associations during post-glacial primary succession is not yet fully understood. Here, we analyzed chronosequences in front of two receding glaciers with contrasting climatic conditions (wetter vs drier) at Cordillera Darwin (Tierra del Fuego) and found that most mosses had the capacity to support an epiphytic flora of cyanobacteria and exhibited high rates of N2 fixation. Pioneer moss-cyanobacteria associations showed the highest N2 fixation rates (4.60 and 4.96 µg N g−1 bryo. d−1) very early after glacier retreat (4 and 7 years) which may help accelerate soil development under wetter conditions. In drier climate, N2 fixation on bryophyte-cyanobacteria associations was also high (0.94 and 1.42 µg N g−1 bryo. d−1) but peaked at intermediate-aged sites (26 and 66 years). N2 fixation capacity on bryophytes was primarily driven by epiphytic cyanobacteria abundance rather than community composition. Most liverworts showed low colonization and N2 fixation rates, and mosses did not exhibit consistent differences across life forms and habitat (saxicolous vs terricolous). We also found a clear relationship between cyanobacteria genera and the stages of ecological succession, but no relationship was found with host species identity. Glacier forelands in Tierra del Fuego show fast rates of soil transformation which imply large quantities of N inputs. Our results highlight the potential contribution of bryophyte-cyanobacteria associations to N accumulation during post-glacial primary succession and further describe the factors that drive N2-fixation rates in post-glacial areas with very low N deposition. PMID:24819926

  12. Contenido de carbono en un bosque de tierra firme del resguardo Nonuya-Villazul, amazonia colombiana

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    Edwin Paky Barbosa


    Full Text Available La implementación de los programas REDD+ requiere estimaciones precisas del carbono forestal. En este estudio se reporta el contenido de carbono en un bosque de tierra firme del resguardo Villazul-Nonuya RVN de la Amazonia colombiana, con base en una parcela permanente de 6 ha. Se evalúa su variación espacial y la contribución del sotobosque, dos factores poco considerados. Se encontró una biomasa promedio total de 336.1±14.0 t.ha-1; el 11.5% se encuentra en el sotobosque (DAP 1-10 cm y el 88.5% corresponde a árboles con DAP ≥ 10 cm; los árboles grandes (DAP ≥ 70 cm son pocos (4 ±1 por ha y tienen una baja contribución a la biomasa (6.8% en comparación con otros bosques tropicales. La biomasa promedio estimada está dentro del rango reportado para toda la cuenca Amazónica, es superior a la Amazonia Occidental y similar al de Amazonia colombiana. Considerando que el resguardo VN tiene 208 800 ha en bosques de tierra firme, se estimó un promedio total de 31.0 Mt C (95% IC 29.1-32.04. Estos resultados permiten ubicar a los bosques del resguardo VN en un contexto global y mejorar la precisión de las estimaciones de carbono forestal en la Amazonia colombiana.

  13. Guanaco’s diet and forage preferences in Nothofagus forest environments of Tierra del Fuego, Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Quinteros, C.P.; Bava, J.; Gobbi, M.E.; Defossé, G.E.


    Aim of study: Guanaco (Lama guanicoe Müller), is a South American native ungulate widely distributed in Patagonia, which in the island of Tierra del Fuego (TF), extends its habitat into Nothofagus spp. forests. Within these forests, guanacos consume lenga (Nothofagus pumilio) leaves and twigs, and other understory species. The aim of this work was to determine: 1) the spring and summer diet of free ranging guanacos, and 2) which plants, grown in the forest understory, guanacos do prefer, or avoid, in these seasons of great forage abundance. Area of study: Tierra del Fuego (Argentina), on three representative areas which combined Nothofagus forests and adjacent meadows (vegas). Material and Methods: uanacos’ diet was determined by comparing epidermal and non-epidermal plant fragments with micro-histological analyses of feces. The analysis was made from composite samples of fresh feces, collected at the seasons of maximum forage productivity (spring and summer). Main results: During spring, 48% of guanacos’ diet was composed of lenga leaves, 30% of grass-like species, 15% of grasses, and less than 7% of herbs, shrubs, and lichens. In summer, 40% of the diet was composed of grasses, 30% of lenga leaves, 25% of grass-like species and the rest corresponded to herbs, shrubs, and lichens. Within the forest understory, guanaco selected lenga leaves and twigs, grass species were consumed according to their availability (or sometimes rejected), while other herbs were not consumed at all. Research highlights: Guanacos’ consumption preference for lenga, even considering the high availability of other forages, could adversely affect forest regeneration.

  14. El antiguo cementerio de la mision de Río Grande, Tierra del Fuego

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    García Laborde, Pamela


    Full Text Available En el marco del proceso de contacto interétnico ocurrido hacia fines del siglo XIX y principios del XX en Tierra del Fuego, lo acontecido específicamente en la misión salesiana La Candelaria (Rio Grande cobra relevancia por la variedad de registros y fuentes que dicho escenario ofrece. La aproximación historiográfica permitió generar información acerca de la presencia de tuberculosis como causa principal de muerte entre los aborígenes que vivieron en la misión y sobre la dieta, la actividad física y las condiciones en las que vivieron aquellos. Paralelamente tres campañas de excavación realizadas hasta el momento permitieron exhumar restos óseos humanos de once individuos integrantes de la comunidad Selk'nam del cementerio de la misión. El objetivo de este trabajo es presentar los primeros resultados sobre el relevamiento de patologías nutricionales-metabólicas e infecciosas surgidos de los trabajos de campo realizados por todo el equipo de investigación en dicho cementerio. Los resultados hallados muestran hasta el momento una alta frecuencia de indicadores de stress metabólico-nutricional, mayor a la observada en general en restos de aborígenes de Tierra del Fuego en otros contextos arqueológicos. Además, se observaron lesiones infecciosas inespecíficas que también están presentes en frecuencias altas en casos de tuberculosis

  15. Effect of two contemporary root canal sealers on root canal dentin microhardness. (United States)

    Khallaf, Maram E


    Successful root canal treatment depends on proper cleaning, disinfecting and shaping of the root canal space. Pulpless teeth have lower dentin microhardness value compared to that of vital teeth. A material which can cause change in dentin composition may affect the microhardness. Thus the aim of this study was to evaluate and compare the effect of two root canal sealers on dentin microhardness. Forty two single rooted teeth were selected and divided into 3 equal groups; Apexit, iRootSP and control groups (n=14) Each group was then divided into 2 subgroups according to the post evaluation period; 1 week and 2 months (n=7). Root canal procedure was done in the experimental groups and obturation was made using either; Apexit, iRootSP or left unprepared and unobturated in the control group. Roots were sectioned transversely into cervical, middle and apical segments. The three sections of each root were mounted in a plastic chuck with acrylic resin. The coronal dentin surfaces of the root segments werepolished. Microhardness of each section was measured at 500 µm and 1000 µm from the canal lumen. Four way-ANOVA revealed that different tested sealer materials, canal third, measuring distance from the pulp and time as independent variables had statistically non significant effect on mean microhardness values (VHN) at p≤0.001. Among iRootSP groups there was a statistically significant difference between iRoot SP at coronal root portion (87.79±17.83) and iRoot SP at apical root portion (76.26±9.33) groups where (p=0.01). IRoot SP at coronal canal third had higher statistically significant mean microhardness value (87.79±17.83) compared to Apexit at coronal third (73.61±13.47) where (p=0.01). Root canal sealers do not affect dentin microhardness. Key words:Root canal, dentin, sealers, microhardness, bioceramic.

  16. Cochlear implant outcomes in patients with superior canal dehiscence

    NARCIS (Netherlands)

    Puram, Sidharth V.; Roberts, Daniel S.; Niesten, Marlien E F|info:eu-repo/dai/nl/377125202; Dilger, Amanda E.; Lee, Daniel J.


    Objective: To determine whether adult cochlear implant (CI) users with superior canal dehiscence syndrome (SCDS) or asymptomatic superior semicircular canal dehiscence (SCD) have different surgical, vestibular, and audiologic outcomes when compared to CI users with normal temporal bone anatomy.

  17. Surgical endodontic management of infected lateral canals of maxillary incisors. (United States)

    Jang, Ji-Hyun; Lee, Jung-Min; Yi, Jin-Kyu; Choi, Sung-Baik; Park, Sang-Hyuk


    This case report presents surgical endodontic management outcomes of maxillary incisors that were infected via the lateral canals. Two cases are presented in which endodontically-treated maxillary central incisors had sustained lateral canal infections. A surgical endodontic treatment was performed on both teeth. Flap elevation revealed vertical bone destruction along the root surface and infected lateral canals, and microscopy revealed that the lateral canals were the origin of the lesions. After the infected lateral canals were surgically managed, both teeth were asymptomatic and labial fistulas were resolved. There were no clinical or radiographic signs of surgical endodontic management failure at follow-up visits. This case report highlights the clinical significance and surgical endodontic management of infected lateral canal of maxillary incisor. It is important to be aware of root canal anatomy variability in maxillary incisors. Maxillary central incisors infected via the lateral canal can be successfully managed by surgical endodontic treatment.

  18. Intradermal melanocytic nevus of the external auditory canal. (United States)

    Alves, Renato V; Brandão, Fabiano H; Aquino, José E P; Carvalho, Maria R M S; Giancoli, Suzana M; Younes, Eduado A P


    Intradermal nevi are common benign pigmented skin tumors. Their occurrence within the external auditory canal is uncommon. The clinical and pathologic features of an intradermal nevus arising within the external auditory canal are presented, and the literature reviewed.

  19. Radiographic versus electronic root canal working length determination

    Directory of Open Access Journals (Sweden)

    Lumnije Kqiku


    Conclusions: The present ex vivo study showed that electronic root canal working length determination is not superior to radiographic methods. Both methods provided a good performance in determining the root canal working length.

  20. Report from the Panama Canal Stakeholder Working Group. (United States)


    This project assists the Texas Department of Transportation (TxDOT) in assessing the potential impacts of the Panama Canal expansion on Texas ports and the landside transportation system. TxDOT formed a Panama Canal Stakeholder Working Group (PCSWG) ...

  1. Effect of meloxicam and meloxicam with misoprostol on serum prostaglandins and gastrointestinal permeability in healthy beagle dogs


    Roškar Tina; Nemec Svete Alenka; Jerin A.; Butinar J.; Kobal Silvestra


    The aim of the present study was to investigate the effect of meloxicam and meloxicam with misoprostol on prostaglandin E2 (PGE2) and prostaglandin I2 (PGI2) serum concentration, as well as on gastrointestinal permeability. NSAIDs, such as meloxicam, have gastrointestinal side effects, which are due to prostaglandins depletion and topical damage. Seven adult beagle dogs were included in the study. Three different 20 days long treatments were carried out (pl...

  2. Efficacy and specificity of L-692,429, a novel nonpeptidyl growth hormone secretagogue, in beagles. (United States)

    Hickey, G; Jacks, T; Judith, F; Taylor, J; Schoen, W R; Krupa, D; Cunningham, P; Clark, J; Smith, R G


    L-692,429 is a substituted benzolactam that has recently been shown to stimulate GH secretion from rat pituitary cells in vitro with an ED50 of 60 nM. In the current studies, we evaluated the efficacy and specificity of L-692,429 as a GH secretagogue in beagles. L-692,429 at 0.1, 0.25, or 1.0 mg/kg or saline vehicle was administered iv to four male and four female beagles in a balanced cross-over design. Blood samples were collected up to 75 min posttreatment, and serum was assayed for GH, cortisol, PRL, and LH. Mean peak serum GH levels were significantly increased (P < 0.05) by L-692,429 to 13 +/- 2 (mean +/- SEM) ng/ml (0.1 mg/kg), 39 +/- 6 ng/ml (0.25 mg/kg), or 71 +/- 11 ng/ml (1.0 mg/kg) over the saline control value of 3.6 +/- 0.6 ng/ml. Mean peak GH levels occurred at 15 min and had returned to near-baseline levels by 75 min. There was no difference in response between sexes. Mean peak cortisol levels were significantly increased (P < 0.05) by 2.2-, 2.7-, and 3.1-fold above control levels (3.0 +/- 0.2 micrograms/dl) at 25-35 min and returned to near-baseline levels by 75 min. PRL was slightly decreased after L-692,429 treatment, whereas LH was not affected. In a second study, three groups of three male beagles each were administered 5.0 mg/kg L-692,429, iv; iv saline, or 2.2 U/kg ACTH, im. Blood was collected for 8 h posttreatment and assayed for GH, cortisol, ACTH, aldosterone, PRL, insulin, T3, and T4. L-692,429 administration significantly increased (P < 0.05) GH over the control level (6.0 +/- 3.6 ng/ml) to 133 +/- 14 ng/ml by 15 min, with a return to pretreatment levels by 120 min. Cortisol levels were significantly increased (P < 0.05) by 2.0-fold (L-692,429) or 2.9-fold (ACTH) over the saline control peak concentration of 5.6 +/- 1.6 micrograms/dl and were associated with concurrent increases in ACTH levels of 1.2-fold (L-692,429) or 2.1-fold (ACTH) over the saline control peak concentration of 67 +/- 20 pmol/L. Aldosterone, PRL, T3, and T4 were not

  3. Viscoelastic assessment of anal canal function using acoustic reflectometry

    DEFF Research Database (Denmark)

    Mitchell, Peter J; Klarskov, Niels; Telford, Karen J


    Anal acoustic reflectometry is a new reproducible technique that allows a viscoelastic assessment of anal canal function. Five new variables reflecting anal canal function are measured: the opening and closing pressure, opening and closing elastance, and hysteresis.......Anal acoustic reflectometry is a new reproducible technique that allows a viscoelastic assessment of anal canal function. Five new variables reflecting anal canal function are measured: the opening and closing pressure, opening and closing elastance, and hysteresis....

  4. Pharmacokinetics and pharmacodynamics (PK/PD) of irbesartan in Beagle dogs after oral administration at two dose rates. (United States)

    Carlucci, L; Song, K H; Yun, H I; Park, H J; Seo, K W; Giorgi, M


    Irbesartan (Irb) is an angiotensin II type 1 receptor antagonist widely used in humans to treat hypertension. Age-related diseases such as hypertension are increasingly being diagnosed in dogs and there is the need for new drugs. The PK/PD of Irb was tested in Beagle dogs. Ten healthy Beagles were orally administered two dose rates (2 and 5 mg/kg), according to a cross over study design. Blood collections for PK analysis and systolic blood pressure (SBP), heart and respiratory rate, mucous membranes colour, capillary refill time and temperature evaluations were performed at scheduled intervals. The drug plasma concentration was dose dependent. The dogs administered 5 mg/kg showed a significant reduction in SBP, while in those receiving 2 mg/kg, this parameter was minimally affected. A counter clockwise hysteresis showed no direct correlation between SBP and plasma concentrations. The minimum effective concentration was theorized to be within the range 550-800 ng/mL. Although further studies are necessary, 5 mg/kg seems to be the more appropriate dose to obtain a hypotensive effect in Beagle dogs.

  5. Sublittoral Harpacticoida (Crustacea, Copepoda from the Magellan Straits and the Beagle Channel (Chile. Preliminary results of abundance and generic diversity

    Directory of Open Access Journals (Sweden)

    Kai Horst George


    Full Text Available Samples of meiofauna were collected with a Multicorer during the Magellan `Victor Hensen´ Campaign of RV `Victor Hensen´ in 1994 at 62 stations along the Magellan Straits and the Beagle Channel. Seventeen samples were analysed in the framework of a larger project. Only 69 species of Harpacticoida are known from Chile so far, all of them inhabiting the littoral zone. The Magellan Campaign of RV `Victor Hensen´ provided the first opportunity to obtain sublittoral samples of meiobenthos of Chilean coasts. In these samples the Copepoda were represented by 4 of its orders: Calanoida, Cyclopoida, Poecilostomatoida and Harpacticoida, the latter exhibiting the highest abundances. Representatives of 19 harpacticoid families (6 of which are new for Chilean waters were identified in the samples. The species found in 15 of these families belong to 28 genera of which 18 are new to the Chilean fauna. With respect to taxa composition and distribution, the following preliminary results can be presented: the number of new families and new genera for the southern tip of South America increased considerably; a relatively high similarity between the Magellan Straits/Beagle Channel and areas of corresponding northern latitudes can be observed; the Magellan Straits and Beagle Channel show considerable differences with respect to taxa composition and diversity of the harpacticoid fauna.

  6. Modelling the Beagle 2 landing site in Isidis Planitia and comparison with the results from the Planetary Fourier Spectrometer (United States)

    Arnold, G.; Helbert, J.; Benkhoff, J.; Hirsch, H.; Maturilli, A.; Formisano, V.; Giuranna, M.

    Within its first orbits Mars Express has passed over Isidis Planitia and the Beagle 2 landing site. From these passes we have derived first estimates on the surface temperature for the likely landing site of Beagle 2 using in the Long Wavelength Channel (5 to 45 μ m) of the Planetary Fourier Spectrometer (PFS) on Mars Express. In our group the Berlin Mars near Surface Thermal model (BMST) has been developed of the last years, to study the thermal behaviour of the near surface layer on Mars (Helbert and Benkhoff 2003). Using this model various locations on Mars have been studied, including the Beagle 2 landing site in Isidis Planitia. For this location temperature gradients within the top 100m below the surface have been calculated. Based on the modelling it was possible to derive estimates on the minimal burial depth of possible ground ice deposits (Helbert and Benkhoff 2003, 2004). The model yields also maps of the surface temperatures for LS 340-70, which can now be compared to first estimates on the surface temperature derived from PFS data. This comparison can be used to further refine the modelling and derive constraints on the thermo-physical properties of the surface material in Isidis Planitia.

  7. [Impact of different degree pulpitis on cell proliferation and osteoblastic differentiation of dental pulp stem cell in Beagle immature premolars]. (United States)

    Ling, L; Zhao, Y M; Ge, L H


    To compare the proliferation and osteoblastic differentiation of dental pulp stem cell (DPSC) isolated from normal and inflamed pulps of different degrees in Beagle immature premolars, and provide evidence for the use of inflammatory DPSC (IDPSC). This study evaluated 14 Beagle's young premolars (21 roots). In the experiment group, irreversible pulpitis was induced by pulp exposure and the inflamed pulps were extracted 2 weeks and 6 weeks after the pulp chamber opening.For the control group, normal pulps were extracted immediately after the exposure. HE staining and real-time PCR were performed to confirm the inflammation. The cells were isolated from the inflamed and normal pulps (IDPSC and DPSC). Cell proliferation and osteoblastic differentiation potentials of the two cells were compared. Inflammation cells infiltration was observed in the inflamed pulps by HE staining. The expression of inflammatory factor was much higher in the 6 week inflamed pulp. IDPSC had higher potential of cell proliferation and osteoblastic differentiation potentials. Furthermore, the osteoblastic differentiation potentials of IDPSC from 2 week inflamed pulp were higher than those from 6 week inflamed pulp. The potential of cell proliferation and osteoblastic differentiation of DPSC was enhanced at early stage of irreversible pulpitis, and reduced at late stage in Beagle immature premolars.

  8. Knowing for controlling: ecological effects of invasive vertebrates in Tierra del Fuego Conocer para controlar: efectos ecológicos de vertebrados invasores en Tierra del Fuego

    Directory of Open Access Journals (Sweden)



    Full Text Available The Tierra del Fuego (TDF archipelago is recognized as part o the last places on Earth that may still be considered wild. However, this condition may be threatened by the large number of invasive species present on the archipelago. These species can have significant effects on the ecology of the invaded ecosystems, at the genetic as well as at population, community and ecosystem levels. The aim of this study is to, by a bibliographic review, systematize existing information on the ecological impacts these species would be having on the TDF archipelago and detect information gaps in order to orient future research and effective management programs on these species. We restricted our review to vertebrate, non-marine invaders. We determined which species have invaded TDF, described their impacts on the archipelago and evaluated their potential impacts; this last issue was determined by reviewing some of the impacts these species have had in other geographic areas. Our findings indicate that at least nine vertebrate species (Salmo trutta, Salvelinus fontinalis, Oncorhynchus mykiss, Castor canadensis, Ondatra zibethicus, Oryctolagus cuniculus, Pseudalopex griseus, Mustela vison and Sus seroja have wild populations established away from human settlements in TDF. There is some scientific evidence on ecological impacts on the area for only five of these invaders, with the American beaver (Castor canadensis being the species monopolizing the greatest number of studies. These results contrast with the recognition, both in TDF and worldwide, of the potential of most of these species to cause significant ecological impacts, which makes it unlikely that the lack of verified impacts on TDF reflects an absence of significant effects of these invaders on the archipelago. We suggest that future research should focus on determining population density and distribution of these and other (i.e., feral species invasive vertebrates, as well as their impacts mainly on


    National Research Council Canada - National Science Library

    Gloria Patricia Zuluaga Sánchez


    ... económicas y/o se vinculan a grupos armados. Los objetivos fueron documentar y analizar los efectos que generan el acceso y control de la tierra por parte de las mujeres campesinas de dichas organizaciones. La...

  10. Claroscuros del desarrollo sustentable y la lucha contra la desertificacion: las racionalidades economicas en el ojo de la tormenta. Estudio de caso con productores caprinos de tierras secas

    National Research Council Canada - National Science Library

    Torres, Laura


    El trabajo analiza la situacion de conflicto que se presenta en las tierras secas de Mendoza, entre productores caprinos y programas de lucha contra la desertificacion, a proposito de las practicas...

  11. Cambios en la cubierta vegetal, usos de la tierra y escenarios futuros en la region costera del estado de Oaxaca, Mexico

    National Research Council Canada - National Science Library

    Leija-Loredo, Edgar G; Reyes-Hernandez, Humberto; Reyes-Perez, Oscar; Flores-Flores, Jose L; Sahagun-Sanchez, Francisco J


    .... Los objetivos de este trabajo fueron analizar los cambios en la cubierta vegetal y el uso de la tierra en dos municipios de la region costera del estado de Oaxaca en el periodo 2000-2011, conocer...

  12. The ontogeny of expression of communicative genes in coyote-beagle hybrids. (United States)

    Moon-Fanelli, Alice


    Although there are minimal genetic differences between the coyote (Canis latrans), the gray wolf (Canis lupus), and the domestic dog (Canis familiaris), these three species are extremely different in numerous aspects of their physiology, morphology, and behavior. In particular, the threat display of coyotes differs markedly from dogs and wolves. Coyotes display a wide open mouth gape-threat with attendant arched back defensive posture, and hiss vocalization. In our experience, this threat display is absent from the repertoire of the domestic dog and the gray wolf. We hypothesized that the foundation of these differences in species-typical threat displays is genetic. The threat displays of coyote-beagle crosses (F1's, F2's, F3's, F1F2's and beagle backcrosses), included the following phenotypes: that of each parental species, that of the domestic dog during pre-pubertal development switching spontaneously to the coyote gape-threat following sexual maturation; and a comparable phenotype requiring exposure to post-pubertal social stress-priming to bring the encoded genetic potential for the gape-threat to expression. The changeover from the dog snarl-threat to the coyote gape-threat was accompanied by a precipitous rise in endogenous cortisol levels over baseline. We hypothesized that where alternative genetic systems are physically available, their selective expression in development may depend on environmental events, such as social stress, to affect internal mechanisms that ultimately control the phenotype. Exogenously elevated cortisol levels, in the absence of the subjective experience of social stress, were associated with the onset of the expression of the coyote threat pattern in an F1 hybrid possessing a full haploid complement of coyote genes and his backcross offspring resulting from a breeding to his F2 daughter. With oral doses of hydrocortisone, the cortisol levels were substantially elevated over basal levels. With endogenous cortisol priming, an

  13. Alterations with age in peripheral blood lymphocyte subpopulations and cytokine synthesis in beagles

    Directory of Open Access Journals (Sweden)

    Ohtsuka H


    Full Text Available Megumi Fujiwara,1,2 Tomohiro Yonezawa,3 Toshiro Arai,1 Ichiro Yamamoto,1 Hiromichi Ohtsuka21Laboratory of Veterinary Biochemistry, Nippon Veterinary and Life Science University, Tokyo, Japan; 2Laboratory of Large Animal Internal Medicine, 3Laboratory of Veterinary Physiology, Kitasato University, Towada, JapanPurpose: The immune system is considered to be affected by aging, which is linked to various immune pathogeneses. The purpose of this study was to determine age-associated changes in immune function of healthy dogs (beagles, specifically those of naive and memory T lymphocytes, based on cytokine synthesis.Patients and methods: Blood samples were obtained from 44 healthy beagles that were divided into three age-groups: young (<4 years, middle-aged (4–8 years, and older dogs (>8 years. Subpopulations of T lymphocytes were determined by flow cytometry. Transcriptional (mRNA levels of cytokines were determined for primary-cultured leukocytes using quantitative real-time polymerase chain reaction.Results: There were negative correlations between dogs’ages and the number of peripheral blood mononuclear cells, T cells, and B cells. In particular, the number of naive CD4+ CD45RA+ T cells and CD8+ CD45RA+ T cells significantly decreased with age. The mRNA levels for interleukin (IL-2, IL-2Rα, and interferon-gamma were significantly higher in young or middle-aged dogs (P < 0.05, whereas IL-4 mRNA expression was not significantly different over the different age-groups. IL-2Rγ mRNA expression tended to decrease with age.Conclusion: Decreases of naive CD4+ and naive CD8+ T cells may be related to age-related immunosenescence in dogs. With regard to cytokine production, leukocyte IL-4 and IL-10 mRNA levels did not change with age, whereas IL-2, IL-2Rα, and IL-2Rγ mRNA levels decreased with age. These altered cytokine mRNA expression patterns may contribute to decreased naive T-cell function(s with aging.Keywords: aging, leukocyte subpopulation

  14. 75 FR 32275 - Regulated Navigation Area; Gulf Intracoastal Waterway, Inner Harbor Navigation Canal, Harvey... (United States)


    ..., Inner Harbor Navigation Canal, Harvey Canal, Algiers Canal, New Orleans, LA AGENCY: Coast Guard, DHS...), Harvey Canal, and Algiers Canal during severe hurricane conditions. Vessels will not be permitted to stay... communities within the IHNC, Harvey, and Algiers Canals from potential hazards associated with vessels being...

  15. 21 CFR 872.3820 - Root canal filling resin. (United States)


    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Root canal filling resin. 872.3820 Section 872...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3820 Root canal filling resin. (a) Identification. A root canal filling resin is a device composed of material, such as methylmethacrylate, intended...

  16. 5 CFR 550.714 - Panama Canal Commission employees. (United States)


    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Panama Canal Commission employees. 550... PAY ADMINISTRATION (GENERAL) Severance Pay § 550.714 Panama Canal Commission employees. (a) Notwithstanding any other provisions of this subpart, an employee separated from employment with the Panama Canal...

  17. Maxillary First Premolar with Three Root Canals: A Case Report ...

    African Journals Online (AJOL)

    ... the tooth is needed to ensure a proper endodontic treatment. This article reports a rare finding of three canals in a maxillary first premolar with non well defined root outline radiographically during an elective root canal treatment. Keywords: Maxillary First Premolar, Endodontic Treatment, Elective, Root Canal Morphology ...

  18. Lumbar Vertebral Canal Diameters in Adult Ugandan Skeletons ...

    African Journals Online (AJOL)

    Background: Normal values of lumbar vertebral canal diameters are useful in facilitating diagnosis of lumbar vertebral canal stenosis. Various studies have established variation on values between different populations, gender, age, and ethnic groups. Objectives: To determine the lumbar vertebral canal diameters in adult ...

  19. The crazy project – Canal Istanbul

    Directory of Open Access Journals (Sweden)

    Seda Kundak


    Full Text Available It was late April 2011 when “the Crazy Project - Canal Istanbul” was proposed by the Prime Minister of Turkey, during his election campaign.  Although the idea of an artificial canal is not new, since it is initiated without any consensus between the people and institutions in Istanbul, the project immediately set a large number of debates. These vary from the legitimacy of decentralization of governance, to potential impacts of the canal on international politics, economy, environment and urban life.  Regarding past infrastructure projects in Istanbul, such large scale investments have caused extensive acceleration in construction sector in one hand and social and economic shifts on the other.  In this paper, the Canal Istanbul Project is evaluated according to basic motivations and claims of the PM, multi-perspective view through challenges and limitation that the project is likely to face with and speculations on implementation approach. The final discussion on the project is based on benefits/losses of Istanbul once the project will be implemented.

  20. Cancer of the external auditory canal

    DEFF Research Database (Denmark)

    Nyrop, Mette; Grøntved, Aksel


    OBJECTIVE: To evaluate the outcome of surgery for cancer of the external auditory canal and relate this to the Pittsburgh staging system used both on squamous cell carcinoma and non-squamous cell carcinoma. DESIGN: Retrospective case series of all patients who had surgery between 1979 and 2000. M...

  1. Infrared typmanic tempature and ear canal morphology

    NARCIS (Netherlands)

    Daanen, H.A.M.


    Several publications indicate that the infrared tympanic temperature (IRTT) underestimates the core temperature of the body when the ear canal is long, curvy and narrow. In order to quantify these observations, a study was performed in 10 subjects. The IRTT was determined and compared to the

  2. The Panama Canal and Social Justice. (United States)

    Wilde, Margaret D., Ed.

    The booklet, designed to explore the issues of international justice in the context of the Gospel, reviews relations between the United States and Panama. It includes background materials and a study guide for parish leaders and other educators. The central question pertaining to the Panama Canal concerns the rights of the United States according…

  3. Residuos de antimicrobianos en canales de vacas

    National Research Council Canada - National Science Library



    Con la finalidad de conocer la presencia de residuos de antibióticos y sulfamidas en animales de abasto, se analizaron las canales de 300 vacas faenadas en una Planta Faenadora de Carnes de la X Región de Chile...

  4. Semiconductor laser irradiation improves root canal sealing during routine root canal therapy


    Su, Dandan; Hu, Xingxue; Wang, Dashan; Cui, Ting; Yao, RuYong; Sun, Huibin


    Objective To evaluate the effect of semiconductor laser irradiation on root canal sealing after routine root canal therapy (RCT). Methods Sixty freshly extracted single-rooted human teeth were randomly divided into six groups (n = 10). The anatomic crowns were sectioned at the cementoenamel junction and the remaining roots were prepared endodontically with conventional RCT methods. Groups A and B were irradiated with semiconductor laser at 1W for 20 seconds; Groups C and D were ultrasonically...

  5. MR determination of neonatal spinal canal depth

    Energy Technology Data Exchange (ETDEWEB)

    Arthurs, Owen, E-mail: [Centre for Cardiovascular MR, Great Ormond Street Hospital for Children, London WC1N 3JH (United Kingdom); Thayyil, Sudhin, E-mail: [Academic Neonatology, Institute for Women' s Health, London WC1E 6AU (United Kingdom); Wade, Angie, E-mail: [Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London (United Kingdom); Chong, W.K., E-mail: [Paediatric Neuroradiology, Great Ormond Street Hospital for Children, London (United Kingdom); Sebire, Neil J., E-mail: [Histopathology, Great Ormond Street Hospital for Children, London WC1E 6AU (United Kingdom); Taylor, Andrew M., E-mail: [Centre for Cardiovascular MR, Cardiorespiratory Unit, Great Ormond Street Hospital for Children and UCL Institute of Cardiovascular Science, London WC1E 6AU (United Kingdom)


    Objectives: Lumbar punctures (LPs) are frequently performed in neonates and often result in traumatic haemorrhagic taps. Knowledge of the distance from the skin to the middle of the spinal canal (mid-spinal canal depth - MSCD) may reduce the incidence of traumatic taps, but there is little data in extremely premature or low birth weight neonates. Here, we determined the spinal canal depth at post-mortem in perinatal deaths using magnetic resonance imaging (MRI). Patients and methods: Spinal canal depth was measured in 78 post-mortem foetuses and perinatal cases (mean gestation 26 weeks; mean weight 1.04 kg) at the L3/L4 inter-vertebral space at post-mortem MRI. Both anterior (ASCD) and posterior (PSCD) spinal canal depth were measured; MSCD was calculated and modelled against weight and gestational age. Results: ASCD and PSCD (mm) correlated significantly with weight and gestational age (all r > 0.8). A simple linear model MSCD (mm) = 3 Multiplication-Sign Weight (kg) + 5 was the best fit, identifying an SCD value within the correct range for 87.2% (68/78) (95% CI (78.0, 92.9%)) cases. Gestational age did not add significantly to the predictive value of the model. Conclusion: There is a significant correlation between MSCD and body weight at post-mortem MRI in foetuses and perinatal deaths. If this association holds in preterm neonates, use of the formula MSCD (mm) = 3 Multiplication-Sign Weight (kg) + 5 could result in fewer traumatic LPs in this population.

  6. Cervical spinal canal narrowing in idiopathic syringomyelia

    Energy Technology Data Exchange (ETDEWEB)

    Struck, Aaron F. [Massachusetts General Hospital, Department of Neurology, Boston, MA (United States); Carr, Carrie M. [Mayo Clinic, Department of Radiology, Rochester, MN (United States); Shah, Vinil [University of California San Francisco, Department of Radiology, San Francisco, CA (United States); Hesselink, John R. [University of California San Diego, Department of Radiology, San Diego, CA (United States); Haughton, Victor M. [University of Wisconsin, Department of Radiology, Madison, WI (United States)


    The cervical spine in Chiari I patient with syringomyelia has significantly different anteroposterior diameters than it does in Chiari I patients without syringomyelia. We tested the hypothesis that patients with idiopathic syringomyelia (IS) also have abnormal cervical spinal canal diameters. The finding in both groups may relate to the pathogenesis of syringomyelia. Local institutional review boards approved this retrospective study. Patients with IS were compared to age-matched controls with normal sagittal spine MR. All subjects had T1-weighted spin-echo (500/20) and T2-weighted fast spin-echo (2000/90) sagittal cervical spine images at 1.5 T. Readers blinded to demographic data and study hypothesis measured anteroposterior diameters at each cervical level. The spinal canal diameters were compared with a Mann-Whitney U test. The overall difference was assessed with a Friedman test. Seventeen subjects were read by two reviewers to assess inter-rater reliability. Fifty IS patients with 50 age-matched controls were studied. IS subjects had one or more syrinxes varying from 1 to 19 spinal segments. Spinal canal diameters narrowed from C1 to C3 and then enlarged from C5 to C7 in both groups. Diameters from C2 to C4 were narrower in the IS group (p < 0.005) than in controls. The ratio of the C3 to the C7 diameters was also smaller (p = 0.004) in IS than controls. Collectively, the spinal canal diameters in the IS were significantly different from controls (Friedman test p < 0.0001). Patients with IS have abnormally narrow upper and mid cervical spinal canal diameters and greater positive tapering between C3 and C7. (orig.)

  7. Cervical spinal canal narrowing in idiopathic syringomyelia. (United States)

    Struck, Aaron F; Carr, Carrie M; Shah, Vinil; Hesselink, John R; Haughton, Victor M


    The cervical spine in Chiari I patient with syringomyelia has significantly different anteroposterior diameters than it does in Chiari I patients without syringomyelia. We tested the hypothesis that patients with idiopathic syringomyelia (IS) also have abnormal cervical spinal canal diameters. The finding in both groups may relate to the pathogenesis of syringomyelia. Local institutional review boards approved this retrospective study. Patients with IS were compared to age-matched controls with normal sagittal spine MR. All subjects had T1-weighted spin-echo (500/20) and T2-weighted fast spin-echo (2000/90) sagittal cervical spine images at 1.5 T. Readers blinded to demographic data and study hypothesis measured anteroposterior diameters at each cervical level. The spinal canal diameters were compared with a Mann-Whitney U test. The overall difference was assessed with a Friedman test. Seventeen subjects were read by two reviewers to assess inter-rater reliability. Fifty IS patients with 50 age-matched controls were studied. IS subjects had one or more syrinxes varying from 1 to 19 spinal segments. Spinal canal diameters narrowed from C1 to C3 and then enlarged from C5 to C7 in both groups. Diameters from C2 to C4 were narrower in the IS group (p < 0.005) than in controls. The ratio of the C3 to the C7 diameters was also smaller (p = 0.004) in IS than controls. Collectively, the spinal canal diameters in the IS were significantly different from controls (Friedman test p < 0.0001). Patients with IS have abnormally narrow upper and mid cervical spinal canal diameters and greater positive tapering between C3 and C7.

  8. Biodegradable effect of PLGA membrane in alveolar bone regeneration on beagle dog. (United States)

    Hua, Nan; Ti, Vivian Lao; Xu, Yuanzhi


    Guided bone regeneration (GBR) is a principle adopted from guided tissue regeneration (GTR). Wherein, GBR is used for the healing of peri-implant bony dehiscences, for the immediate placement of implants into extraction sockets and for the augmentation of atrophic alveolar ridges. This procedure is done by the placement of a resorbable or non-resorbable membrane that will exclude undesirable types of tissue growth between the extraction socket and the soft tissue to allow only bone cells to regenerate in the surgically treated lesion. Here, we investigated the biodegradable effect of polylactic-co-glycolic acid (PLGA) membrane in the alveolar bone on Beagle dogs. Results show that both collagen and PLGA membrane had been fully resorbed, biodegraded, at four weeks post-operative reentry into the alveolar bone. Histological results under light microscopy revealed formation of new bone trabeculae in the extraction sites on both collagen and PLGA membrane. In conclusion, PLGA membrane could be a potential biomaterials for use on GBR and GTR. Nevertheless, further studies will be necessary to elucidate the efficiency and cost effectiveness of PLGA as GBR membrane in clinical.

  9. Invivo absorption behaviour of theophylline from starch-methyl methacrylate matrix tablets in beagle dogs. (United States)

    Fernández-Campos, F; Ferrero, C; Colom, H; Jiménez-Castellanos, M R


    This study evaluates in vivo the drug absorption profiles from potato starch-methyl methacrylate matrices(*) using theophylline as a model drug. Healthy beagle dogs under fasting conditions were used for in vivo studies and plasma samples were analyzed by a fluorescence polarization immunoassay analysis (FPIA method). Non-compartmental and compartmental (population approach) analysis was performed to determine the pharmacokinetic parameters. The principle of superposition was applied to predict multiple dose plasma concentrations from experimental single dose data. An in vitro-in vivo correlation (IVIVC) was also assessed. The sustained absorption kinetics of theophylline from these formulations was demonstrated by comparison with two commercially available oral sustained-release theophylline products (Theo-Dur(®) and Theolair(®)). A one-compartment model with first order kinetics without lag-time best describes the absorption/disposition of theophylline from the formulations. Results revealed a theophylline absorption rate in the order FD-HSMMA≥Theo-Dur(®)≥OD-CSMMA>Theolair(®)≥FD-CSMMA. On the basis of simulated plasma theophylline levels, a twice daily dosage (every 12h) with the FD-CSMMA tablets should be recommended. A Level C IVIVC was found between the in vitrot50% and the in vivo AUC/D, although further optimization of the in vitro dissolution test would be needed to adequately correlate with in vivo data. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. Antibody responses to Borrelia burgdorferi outer surface proteins C and F in experimentally infected Beagle dogs. (United States)

    Callister, Steven M; LaFleur, Rhonda L; Jobe, Dean A; Lovrich, Steven D; Wasmoen, Terri L


    Antibody levels to outer surface proteins C and F (OspC and OspF, respectively) in sera collected from laboratory Beagle dogs at 1, 2, and 4 months after challenge with infected black-legged ticks (Ixodes scapularis) were determined. Each dog was confirmed by culture to harbor Borrelia burgdorferi in the skin (n = 10) or the skin and joints (n = 14). Significant levels of immunoglobulin M (Ig)M or IgG anti-OspC antibodies were detected in single serum samples from only 3 (13%) dogs. Similarly, IgM anti-OspF antibodies were detected in only 1 (4%) serum sample collected from a dog with B. burgdorferi in the skin and joints. In contrast, 4 (29%) dogs with skin and joint infections produced IgG anti-OspF antibodies after 2 months, and the response expanded to include 2 (20%) dogs with skin infection and 4 additional dogs with skin and joint infections (overall sensitivity = 62%) after 4 months. The findings failed to support the utility of OspC-based antibody tests for diagnosing canine Lyme disease, but demonstrated that dogs with B. burgdorferi colonizing joint tissue most often produced significant levels of IgG anti-OspF antibodies. Therefore, additional studies to more thoroughly evaluate the clinical utility of OspF-based antibody tests are warranted. © 2015 The Author(s).

  11. An investigation of the relationship between response latency across several cognitive tasks in the beagle dog. (United States)

    Nippak, Pria M D; Milgram, Norton W


    Response latencies (RLs) extracted from simple motor tasks are a commonly used index of human intelligence. To date few human or animal studies have investigated the relationship between an individuals RL scores across a number of diverse cognitive tasks: Does RL remain consistent between individuals across several cognitive domains? Thus, the current study examined how RL measures gathered from beagle dogs (n=13) tested on three different cognitive tasks were related. RL scores were collected following both discrimination and reversal learning and a test of visuospatial memory, the 3 component delayed non-matching to position (3-DNMP) task. RL scores were recorded from the time the choice stimulus was presented until the animal selected a response. Results indicated that strong correlations emerged between 3-DNMP RLs and both the discrimination and reversal RLs, indicating that animals that responded fast on the 3-DNMP task also responded fast on the discrimination and reversal tasks. Interestingly, 3-DNMP RLs were more strongly correlated with reversal learning RLs. Finally, when mean RL performance across the three tasks was examined, strong RL differences emerged indicating that animals displayed significantly slower RLs on the 3-DNMP task than on the discrimination task, while reversal RLs remained indistinguishable from both. In conclusion, RLs show high between task correlations, indicating individual differences, and also vary between tasks, probably because of differences in task difficulty. These results further validate the use of RLs as an index of cognition, and also highlight the importance of further studies using animal models.

  12. Three-dimensional inverse dynamics of the forelimb of Beagles at a walk and trot. (United States)

    Andrada, Emanuel; Reinhardt, Lars; Lucas, Karin; Fischer, Martin S


    OBJECTIVE To perform 3-D inverse dynamics analysis of the entire forelimb of healthy dogs during a walk and trot. ANIMALS 5 healthy adult Beagles. PROCEDURES The left forelimb of each dog was instrumented with 19 anatomic markers. X-ray fluoroscopy was used to optimize marker positions and perform scientific rotoscoping for 1 dog. Inverse dynamics were computed for each dog during a walk and trot on the basis of data obtained from an infrared motion-capture system and instrumented quad-band treadmill. Morphometric data were obtained from a virtual reconstruction of the left forelimb generated from a CT scan of the same dog that underwent scientific rotoscoping. RESULTS Segmental angles, torque, and power patterns were described for the scapula, humerus, ulna, and carpus segments in body frame. For the scapula and humerus, the kinematics and dynamics determined from fluoroscopy-based data varied substantially from those determined from the marker-based data. The dominant action of scapular rotation for forelimb kinematics was confirmed. Directional changes in the torque and power patterns for each segment were fairly consistent between the 2 gaits, but the amplitude of those changes was often greater at a trot than at a walk. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that control of the forelimb joints of dogs is similar for both a walk and trot. Rotation of the forelimb around its longitudinal axis and motion of the scapula should be reconsidered in the evaluation of musculoskeletal diseases, especially before and after treatment or rehabilitation.

  13. Ovariectomy-induced changes in aged beagles : histomorphometry of rib cortical bone.

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    Wilson, A. K.; Bhattacharyya, M. H.; Miller, S.; Sacco-Gibson, N.; Center for Mechanistic Biology and Biotechnology; Univ. of Utah; Procter & Gamble Pharmaceuticals


    Bone loss associated with estrogen depletion is well documented in cancellous bone but less well characterized in cortical bone. The effects of ovariectomy on the aged beagle skeleton were studied by histomorphometric analysis of the cortical bone in sequential rib biopsies. Biopsies were taken from each ovariectomized or sham-operated dog at the time of surgery and at 1, 4, and 8.5 months after surgery. Just prior to each postoperative biopsy, tetracycline, calcein, and xylenol orange, respectively, were administered by a fluorochrome labeling procedure (2d-10d-2d) to provide markers of bone formation. Analysis of sequential rib biopsies provided a means to follow the ovariectomy response over time and to compare each animal against its own baseline. Though ovariectomy did not influence histomorphometric indices at 1 month after surgery, a transient increase in cortical bone formation occurred thereafter, with a sixfold increase over that of sham-operated dogs at 4 months (P < 0.001) and a return to near control levels at 8.5 months. Cortical porosity increased by the fourth month after ovariectomy and remained high at 8.5 months. These data demonstrate for the first time that rib cortical bone is a responsive site for the effects of ovariectomy in aged female dogs.

  14. Asymptomatic macrothrombocytopenia in a young pure-bred beagle dog: a case report. (United States)

    Bodié, Karen; Gagne, Gerard D; Sramek, Mary K; Desmond, David J; Abel, Stephen J; Fagerland, Jane A


    During baseline evaluation prior to a preclinical safety study, a 10-month-old male pure-bred Beagle dog was found to have marked thrombocytopenia (6 × 10(3) platelets [PLT]/µL) associated with a mean platelet volume (MPV) of 17.9 fL. Tests for Rickettsia rickettsii, Ehrlichia canis, and Borrelia burgdorferi were negative. Buccal bleeding time was normal. Over 3 months, PLT were 4 to 141 × 10(3) PLT/µL, and MPV was 11.4 to 25.1 fL; however, PLT were 16 fL during most of this period. Antinuclear antibody (ANA) and anti-PLT antibody tests were negative. Genotyping for the presence of a beta 1-tubulin mutation demonstrated the normal wild-type gene. Treatment with prednisone resulted in normal values after only 3 days. Ultrastructure of enlarged PLT was consistent with that of immature PLT, characterized by reduced numbers of peripheral microtubules and the presence of rough endoplasmic reticulum, free ribosomes, Golgi apparatus, and a prominent canalicular system. PLT ultrastructure and glucocorticoid responsiveness supported a diagnosis of immune-mediated thrombocytopenia that was masked by the cyclic nature of PLT decreases and lack of clinical signs. Inclusion of such a dog in a preclinical safety study could result in misinterpretation of clinical pathology findings.

  15. Ovariectomy-induced changes in aged beagles: Histomorphometry and mineral content of the rib

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    Wilson, A.K.; Bhattacharyya, M.H.; Hurst, D. [Argonne National Lab., IL (United States). Center for Mechanistic Biology and Biotechnology; Miller, S. [Univ. of Utah, Salt Lake City, UT (United States). Radiobiology Div.; Sacco-Gibson, N. [Proctor and Gamble Pharmaceuticals, Cincinnati, OH (United States)


    The effects of ovariectomy on the aged beagle skeleton were studied by histomorphometric analysis of the cortical bone in sequential rib biopsies. Biopsies were taken from each ovariectomized (OV) or sham-operated (SO) dog at the time of surgery and at 1, 4, and 8.5 months after surgery. Tetracycline, calcein, and xylenol orange, respectively, were administered by a fluorochrome labeling procedure (2d-10d-2d) just prior to each postoperative biopsy to provide markers of bone formation. Analysis of sequential biopsies provided a means to follow the response to ovariectomy over time and compare each animal against its own baseline. Examination of sequential biopsies indicated that cortical porosity increased by the fourth month after ovariectomy and remained high at 8.5 months. Ovariectomy did not influence histomorphometric indices at one month after surgery, but substantial differences were observed at later times. Ovariectomy stimulated a transient increase in bone formation and was increased six-fold over that of SO dogs at four months. Ribs were also analyzed for mineral content at necropsy. The rib was heterogeneous along its length for calcium content and concentration. In the midrib where biopsies for histomorphometric analysis were taken, ovariectomy induced a decrease in mass and mineral content; total calcium was decreased by approximately 31%. These data demonstrate that the rib cortical bone is a responsive site for the effects of ovariectomy in female dogs.

  16. Neosporosis in Beagle dogs: clinical signs, diagnosis, treatment, isolation and genetic characterization of Neospora caninum. (United States)

    Dubey, J P; Vianna, M C B; Kwok, O C H; Hill, D E; Miska, K B; Tuo, W; Velmurugan, G V; Conors, M; Jenkins, M C


    Clinical neosporosis was diagnosed in a litter of five pups born to a Beagle bitch from Virginia, USA. Four of the pups developed limb weakness starting at 4 weeks of age. The dogs were suspected to have neosporosis based on clinical signs and empirically treated with Clindamycin (75 mg, oral, twice daily, total 150 mg) starting at 9 weeks of age and the dosage was doubled at 13 weeks of age. Antibodies to Neospora caninum were detected in sera of the dam and pups when first tested serologically at the age of 4 months. The owner donated the pup with the worst clinical signs and the dam for research; both dogs were euthanized. Viable N. caninum was isolated in gamma interferon gene knock out (KO) mice and in cell culture from the pup killed at 137 days of age. Tissue cysts, but no tachyzoites, were found in histological sections of brain and muscles. The isolate was also identified as N. caninum by PCR and sequence analysis and designated NC-9. N. caninum was neither isolated by bioassay in KO mice nor found in histological sections of tissues of the bitch. Clinical signs in the remaining three pups improved considerably after a 6-month treatment with Clindamycin; N. caninum antibody titers were still persistent in these pups at 23 months of age. Results indicate that medication with Clindamycin can improve clinical condition but not eliminate N. caninum infection.

  17. Primary liver tumors in beagle dogs exposed by inhalation to aerosols of plutonium-238 dioxide. (United States)

    Gillett, N. A.; Muggenburg, B. A.; Mewhinney, J. A.; Hahn, F. F.; Seiler, F. A.; Boecker, B. B.; McClellan, R. O.


    Primary liver tumors developed in Beagle dogs exposed by inhalation to aerosols of 238PuO2. Initial deposition of 238PuO2 in the respiratory tract was followed by translocation of a portion of the 238Pu to the liver and skeleton, which resulted in a large dose commitment and tumor risk to all three tissues. In a population of 144 dogs exposed to 238PuO2, 112 dogs died or were killed 4000 days after 238Pu exposure, 100 dogs had osteosarcoma, and 28 dogs had lung cancers. At increasing times after exposure, however, liver lesions have become more pronounced. Ten primary liver tumors in nine animals were diagnosed in the dogs dying before 4000 days after exposure. An additional five primary liver tumors in three dogs occurred in 9 animals killed after 4000 days after exposure. The majority of these tumors have been fibrosarcomas. The liver tumors were usually not the cause of death, and rarely metastasized. The occurrence of liver tumors in this study indicates that 238Pu is an effective hepatic carcinogen. Liver carcinogenesis is assuming an increasing importance in this study at late times after inhalation exposure. These results suggest that the liver may be an important organ at risk for the development of neoplasia in humans at time periods long after inhalation of 238Pu. Images Figure 3 Figure 4 Figure 5 Figure 6 PMID:3142267

  18. Surface morphology of superficial cells in irradiated oral mucosa: an experimental study in beagle dog. (United States)

    Asikainen, Pekka; Mikkonen, Jopi J W; Kullaa, Arja M


    The aim of the present study is to investigate if radiation induces changes in the superficial cells of the oral mucosa and secondly to describe morphological characteristics of the cell surface structure by scanning electron microscopy (SEM). Ten beagle dogs aged 1-2 years were used in this study. One side of each mandible was irradiated in two sessions, each lasting 1 week. The total dosage was 40 Gy (Group A; 5 dogs) and 50 Gy (Group B; 5 dogs), in five fractions of 4 Gy. The other side of mandible (non-irradiated) served as a control. The specimen was harvested with a scalpel from the alveolar mucosa of the irradiated area 1 year after irradiation and studied with SEM. In the control side, the surface structure of the cell contains straight parallel or branched microplicae (MPL), which were equally spaced over the cell surfaces. Discontinuous and short MPL were typical cell structure of irradiated mucosa. In 50 Gy group, the surface structure of epithelial cell was pitted and the cell boundaries were thick. The novelty of the present study is that radiation disrupts superficial cells of the oral mucosa. The role of the MPL structure of the superficial cells in mucositis development is discussed.

  19. Holocene sea-level changes along the Strait of Magellan and Beagle Channel, southernmost South America (United States)

    Porter, Stephen C.; Stuiver, Minze; Heusser, Calvin J.


    Radiocarbon-dated marine sediments from five coastal sites along the Strait of Magellan and Beagle Channel in southernmost Chile permit construction of a curve of relative sea-level fluctuations during the Holocene. Morphologic and stratigraphic data point to coastal submergence during the early Holocene as the sea rose to a maximum level at least 3.5 m higher than present about 5000 yr ago. Progressive emergence then followed during the late Holocene. Data from widely separated localities define a smooth curve, the form of which is explainable in terms of isostatic and hydroisostatic deformation of the crust resulting from changing ice and water loads. Apparently anomalous data from one site located more than 100 km behind the outer limit of the last glaciation may reflect isostatic response to deglaciation. The sea-level curve resembles one derived by Clark and Bloom (1979, In "Proceedings of the 1978 International Symposium on Coastal Evolution in the Quaternary, Sao Paulo, Brasil," pp. 41-60. Sao Paulo) using a spherical Earth model, both in amplitude and in the timing of the maximum submergence.

  20. Heavy metals monitoring in the southernmost mussel farm of the world (Beagle Channel, Argentina). (United States)

    Giarratano, Erica; Amin, Oscar A


    Water quality surrounding the mussel farm of Mytilus edulis chilensis at Brown Bay (Beagle Channel) was evaluated. The levels of five heavy metals in sediment and in gill and digestive gland of mussels were examined to consider potential risks to human health. Cd showed the highest enrichment factor in relation to its level in Earth crust (3.85-21.58), which could be related to an upwelling phenomenon. A seasonal trend was found regarding metal bioaccumulation, being higher in winter than in summer. The bioaccumulation pattern in gill was Zn>Fe>Cu>Cd, meanwhile in digestive gland was Fe>Zn>Cu>Cd. Despite Pb was measured in sediment (15.59-23.91 microg/g dw), it was not available for being incorporated by mussels. In all cases it was below the detection limit (2.37 microg/g dw). With regard to human consumption of mussels from Brown Bay, none of the elements analyzed should cause concern for consumers. Values measured in tissue mussels were below the limit of 10 microg/g dw for Cd and Pb established by SENASA for molluscs. Considering that studied mussels are for human consumption and the relatively high levels of metals in sediment may vary their availability if physical parameters changes, periodical monitoring must be carried out to avoid human risks and to produce food in a responsible manner that complies with the food safety standards. Copyright (c) 2010 Elsevier Inc. All rights reserved.

  1. Seasonal phytoplankton dynamics in extreme southern South America (Beagle Channel, Argentina) (United States)

    Almandoz, Gastón O.; Hernando, Marcelo P.; Ferreyra, Gustavo A.; Schloss, Irene R.; Ferrario, Martha E.


    The phytoplankton biomass and composition dynamics in relation with environmental factors were explored during an annual cycle (July 2006-2007) for the first time in the Beagle Channel. Samples were examined by light and scanning electron microscopy and carbon biomass was estimated using measured cell biovolumes. The annual cycle was characterized by a sharp contrast between low density and biomass during the autumn-winter period and a significant increase during spring and summer. The maximum biomass peak was observed during early spring (141 μg C l - 1 and 8.7 μg Chl a l - 1 ) and was associated with a bloom of the diatom genus Chaetoceros. In spite of a strong nutrient depletion that lead to the subsequent bloom decline, a second peak of biomass was observed after 2 weeks, mainly represented by the diatoms T. mendiolana and T. anguste-lineata. Towards the end of spring and during summer diatom density decreased and assemblages were enriched by unidentified tiny phytoflagellates and dinoflagellates. A total of 138 taxa were identified during the study period. From these, 10 are known as potentially toxic species: Alexandrium catenella, A. ostenfeldii, A. tamarense, Dinophysis acuminata, D. rotundata, Prorocentrum cordatum, Pseudo-nitzschia australis, P. calliantha, P. fraudulenta and P. cf. seriata. Their presence is noteworthy since the area sustains a growing aquiculture production.

  2. Comparison of Different Periodontal Healing of Critical Size Noncontained and Contained Intrabony Defects in Beagles. (United States)

    Zang, Sheng-Qi; Kang, Shuai; Hu, Xin; Wang, Meng; Wang, Xin-Wen; Zhou, Tao; Wang, Qin-Tao


    Regenerative techniques help promote the formation of new attachment and bone filling in periodontal defects. However, the dimensions of intraosseous defects are a key determinant of periodontal regeneration outcomes. In this study, we evaluated the efficacy of use of anorganic bovine bone (ABB) graft in combination with collagen membrane (CM), to facilitate healing of noncontained (1-wall) and contained (3-wall) critical size periodontal defects. The study began on March 2013, and was completed on May 2014. One-wall (7 mm × 4 mm) and 3-wall (5 mm × 4 mm) intrabony periodontal defects were surgically created bilaterally in the mandibular third premolars and first molars in eight beagles. The defects were treated with ABB in combination with CM (ABB + CM group) or open flap debridement (OFD group). The animals were euthanized at 8-week postsurgery for histological analysis. Two independent Student's t-tests (1-wall [ABB + CM] vs. 1-wall [OFD] and 3-wall [ABB + CM] vs. 3-wall [OFD]) were used to assess between-group differences. The mean new bone height in both 1- and 3-wall intrabony defects in the ABB + CM group was significantly greater than that in the OFD group (1-wall: 4.99 ± 0.70 mm vs. 3.01 ± 0.37 mm, P periodontal regeneration than that in 3-wall intrabony defect. The noncontained 1-wall intrabony defect might be a more discriminative defect model for further research into periodontal regeneration.

  3. Myenteric plexus is differentially affected by infection with distinct Trypanosoma cruzi strains in Beagle dogs

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    Nívia Carolina Nogueira-Paiva


    Full Text Available Chagasic megaoesophagus and megacolon are characterised by motor abnormalities related to enteric nervous system lesions and their development seems to be related to geographic distribution of distinct Trypanosoma cruzi subpopulations. Beagle dogs were infected with Y or Berenice-78 (Be-78 T. cruzi strains and necropsied during the acute or chronic phase of experimental disease for post mortem histopathological evaluation of the oesophagus and colon. Both strains infected the oesophagus and colon and caused an inflammatory response during the acute phase. In the chronic phase, inflammatory process was observed exclusively in the Be-78 infected animals, possibly due to a parasitism persistent only in this group. Myenteric denervation occurred during the acute phase of infection for both strains, but persisted chronically only in Be-78 infected animals. Glial cell involvement occurred earlier in animals infected with the Y strain, while animals infected with the Be-78 strain showed reduced glial fibrillary acidic protein immunoreactive area of enteric glial cells in the chronic phase. These results suggest that although both strains cause lesions in the digestive tract, the Y strain is associated with early control of the lesion, while the Be-78 strain results in progressive gut lesions in this model.

  4. Pharmacokinetics of propafenone hydrochloride sustained-release capsules in male beagle dogs

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    Liping Pan


    Full Text Available This paper describes the development and validation of a liquid chromatography–mass spectrometric assay for propafenone and its application to a pharmacokinetic study of propafenone administered as a new propafenone hydrochloride sustained-release capsule (SR-test, as an instant-release tablet (IR-reference and as the market leader sustained-release capsule (Rythmol, SR-reference in male beagle dogs (n=8. In Study A comparing SR-test with IR-reference in a crossover design Tmax and t1/2 of propafenone for SR-test were significantly higher than those for IR-reference while Cmax and AUC were lower demonstrating the sustained release properties of the new formulation. In Study B comparing SR-test with SR-reference the observed Cmax and AUC of propafenone for SR-test (124.5±140.0 ng/mL and 612.0±699.2 ng·h/mL, respectively were higher than for SR-reference (78.52±72.92 ng/mL and 423.6±431.6 ng·h/mL, respectively although the differences were not significant. Overall, the new formulation has as good if not better sustained release characteristics to the market leader formulation.

  5. Comparison of soft tissue healing around implants in beagle dogs: flap surgery versus flapless surgery. (United States)

    Lei, Qun; Chen, Jiang; Jiang, Jianhui; Fu, Xiaoming; Lin, Hengzhang; Cai, Zhiyu


    The objective of this study was to compare soft tissue healing after implant placement in flap and flapless surgery in the dog model. Mandibular premolars were extracted from 10 beagle dogs. The extraction sockets were allowed to heal for 8 weeks. After healing, 3 implants on each side of the mandible were implanted using either flap or flapless techniques. One implant was installed on each side at the 0-, 4-, and 6-week time point. Eight weeks later, the peri-implant soft tissue healing was subjected to clinical and immunohistochemical analysis. It was revealed that vascular endothelial growth factor (VEGF) expression, peri-implant crevicular fluid (PICF) volume, and the aspartate aminotransferase and alkaline phosphatase activity in PICF increased significantly in the 2-week flap group compared with the 2-week flapless group. Microvascular density and VEGF expression in the 8-week flap group was statistically significantly lower than the 8-week flapless group and normal group. Buccal gingival recession was less pronounced in the flapless group than in the flap group after 4 and 8 weeks. Within the limits of this study, the results demonstrate that flapless surgery contributes to better esthetic outcomes in implants compared with the flap approach. Crown Copyright © 2013. Published by Mosby, Inc. All rights reserved.

  6. Titanium endosteal dental implants in the mandibles of beagle dogs: a 2 year study. (United States)

    Gourley, I M; Richards, L W; Cordy, D R


    Forty of 44 vented endosteal blade implants were well tolerated by the mandibular tissues of beagle dogs, as demonstrated clinically, radiographically, and histologically. Infection and inflammation were not observed. The epithelium did not invade along the neck of the implants more than 2 mm. below the mandibular crest. After 3 to 6 months, except for increasing density of bone at the metal interface, no distinct pattern of reaction could be discerned histologically. Except for heavy collagenous investment in three dogs, there was no sign of the implants being treated as sterile foreign bodies. In this study, histology did not provide good criteria for evaluating the failure of vented endosteal blade implants. In four implants which failed, the most reliable signs of failure were increased mobility and/or sulcus depth around the neck of the abutments. Radiographic evaluation of implants provided the best means of determining bone resorption. Bone resorption was apparent 3 to 6 months after implantation, did not appear to be progressive, and did not indicate implant failure or impending implant failure in those animals in which it occurred. Radiolucent areas observed in 29 of the specimens contained connective tissue, marrow spaces, thin bone trabeculae, and nonpathologic tissues. Although in some of the dogs stress on implants did not cause failure, there is a need for further experimentation involving vented endosteal blades subjected to occlusal loading.

  7. [Histopathology of meibomian gland abnormalities in experimental PenCB intoxicated beagle treated with squalane]. (United States)

    Kohno, T; Ohnishi, Y


    In order to examine the effect of squalane to excrete PCB from the intoxicated animals, histopathological studies of Meibomian gland abnormalities were carried out in experimental PenCB (3,4,5,3',4'-pentachlorobiphenyl) intoxicated beagles treated with squalane. All experimental animals except a control group showed characteristic changes of Meibomian glands: dilation of the duct and squamous metaplasia of the alveolar cells. According to the degree of these findings, five stages were divided in the processes of Medibomian gland changes. The PenCB intoxicated dogs initially showed mild pathological changes of the glands and later moderate to severe degrees of findings. In the PenCB intoxicated animals treated with squalane, severe degree of Meibomian gland findings were found in the early stage and mild to moderate abnormalities in the late stage. The concentration of PenCB in blood varied in each animal, and the animals with advanced Medibomian gland abnormalities tended to have high level of PenCB concentration in blood. In conclusion, the effect of squalane to excrete PCB from the intoxicated animals were not determined in this study.

  8. Effects of Untreated Periodontitis on Osseointegration of Dental Implants in a Beagle Dog Model. (United States)

    Lee, Daehyun; Sohn, Byungjin; Kim, Kyoung Hwa; Kim, Sungtae; Koo, Ki-Tae; Kim, Tae-Il; Seol, Yang-Jo; Lee, Yong-Moo; Rhyu, In-Chul; Ku, Young


    There have been previous studies on the relationship between periodontitis and peri-implantitis, but limited information is available on how periodontitis affects osseointegration and wound healing of newly placed dental implants adjacent to natural teeth. The objective of the present experiment is to evaluate healing around dental implants adjacent to teeth with untreated experimental periodontitis. The study included six male beagle dogs. Scaling and plaque control procedures were performed on three dogs (control group). In the other three dogs (experimental group), retraction cords and ligature wires were placed subgingivally around all premolars and the first molars. Induced experimental periodontitis was confirmed after 3 months. Each control or experimental group was divided into two subgroups depending on the timing of implant placement (immediate/delayed). Twelve dental implants (two implants for each dog) were placed immediately, and the other 12 dental implants (two implants for each dog) were placed 2 months after extraction. The animals were sacrificed 2 months after implant placement. Histologic and histometric analyses were performed. Four implants (three from the immediate placement group and one from the delayed placement group) failed in the experimental group. There were significant differences in the percentage of bone-to-implant contact and marginal bone volume density between the control and experimental groups. Both parameters were significantly lower in the experimental group than in the control group (P implants is associated with a higher failure rate compared with delayed placement. Untreated experimental periodontitis was correlated with compromised osseointegration in the implants with delayed placement.

  9. Acute and sub-chronic oral toxicity studies of erythritol in Beagle dogs. (United States)

    Eapen, Alex K; de Cock, Peter; Crincoli, Christine M; Means, Charlotte; Wismer, Tina; Pappas, Christopher


    Polyols, also known as sugar alcohols, are widely used in the formulation of tooth-friendly and reduced-calorie foods. Considering the significant health benefits of polyols in products formulated for human use, there is increased interest in evaluating potential uses in companion animal applications. Erythritol and xylitol are two polyols which are currently widely used in products ranging from reduced-sugar foods to personal care and cosmetics. Published studies have shown that both of these compounds are well-tolerated in rodents. Their toxicity profiles differ when comparing canine safety data. Doses of xylitol as low as 0.15 g/kg-BW in dogs can result in life-threatening hypoglycemia and acute liver failure, whereas erythritol is well-tolerated in dogs with reported No Adverse Effect Levels upwards of 5 g/kg-BW/day in repeat-dose studies. While pivotal studies substantiating the safe use of erythritol in humans have been published, there are limited published studies to support the safe use of erythritol in dogs. Here we present the results of an acute oral and a sub-chronic oral toxicity study in Beagle dogs. Given the potential health benefits of oral products formulated with erythritol and the data presented herein substantiating the safe use in dogs, erythritol can be safely used in products for canines. Copyright © 2017 Elsevier Ltd. All rights reserved.


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    Zeliha UĞUR


    Full Text Available It is very important that the dentists have sufficient information about possible variations in the expected root canal configurations in order to achieve success in endodontic treatment. In addition to having adequate knowledge on the variations of the root canal anatomy, periapical radiographs from different angles, careful examination of the pulp chamber floor, and use of dental operation microscope during the procedure are also important factors that contribute to the diagnosis of the additional roots and canals. The aims of this article are to present the diagnostic approach and root canal treatments of two maxillary first premolar teeth with three canals in two patients.

  11. Implementación de una empacadora de mango en el valle de tierra caliente de Michoacán


    Sánchez Castañeda, Maximiliano


    El presente estudio, de alguna manera plasma y evalúa la inquietud de un grupo de productores de mango en el valle de tierra caliente de Michoacán. Después de haber tenido pláticas formales e informales con productores, empacadores y trabajadores de esta cadena productiva, así como haber aplicado cuestionarios y llevado a cabo una investigación de campo.

  12. A new genus and new species of felt scales (Homoptera: Coccinea: Eriococcidae from Tierra del Fuego (Chile

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    Ilya A. Gavrilov-Zimin


    Full Text Available Telmatococcus igniumterrae gen. nov. et sp. nov. is described and illustrated based on the material collected from a sphagnum bog in the extreme southern part of South America (Tierra del Fuego. The new monotypic genus differs from all known genera of Eriococcidae in having short cylindrical truncated setae of the anal apparatus and pouches with numerous quinquelocular pores near the anal apparatus. The habitat of the new taxon is characterized.

  13. A new system for classifying tooth, root and canal anomalies. (United States)

    Ahmed, H M A; Dummer, P M H


    Understanding the normal anatomical features as well as the more unusual developmental anomalies of teeth, roots and root canals is essential for successful root canal treatment. In addition to various types of root canal configuration and accessory canal morphology, a wide range of developmental tooth, root and canal anomalies exists, including C-shaped canals, dens invaginatus, taurodontism, root fusion, dilacerations and palato-gingival grooves. There is a direct association between developmental anomalies and pulp and periradicular diseases that usually require a multidisciplinary treatment approach to achieve a successful outcome. A number of classifications have categorized tooth, root and canal anomalies; however, several important details are often missed making the classifications less than ideal and potentially confusing. Recently, a new coding system for classifying root, root canal and accessory canal morphology has been introduced. The purpose of this article is to introduce a new system for classifying tooth, root and canal anomalies for use in research, clinical practice and training, which can serve as complementary codes to the recently described system for classifying root, as well as main and accessory canal morphology. © 2017 International Endodontic Journal. Published by John Wiley & Sons Ltd.

  14. [Measurements of semicircular canal space direction with MRI]. (United States)

    Yang, Xiaokai; Wu, Shuzhi; Ye, Hua


    Measure the space direction of semicircular canals to provide the anatomical basis for the diagnosis and treatment of BPPV. We calculated angles among semicircular canals of 24 patients using MRI scaning with 3D-CISS sequence. The angle between the left and right posterior semicircular canals was 106.61 degress ± 8.58 degrees, so the angle among the posterior semicircular canals and sagittal head plane was 53.31 degrees ± 4.29 degrees. Pairs of contralateral synergistic canal planes were not parallel, forming 171.67 degrees ± 4.36 degrees between the left and right horizontal semicircular canal planes, 154.37 degrees ± 10.87 degrees between the left posterior and right anterior semicircular canal planes and 156.84 degrees ± 9.34 degrees between the right posterior and left anterior semicircular canal planes. Our measurement of the angles among semicircular canals coincided with those of previous reports. The angles between contralateral synergistic canal planes were close to parallel, but the angle between the posterior semicircular canals and sagittal head plane was great than 45 degrees that traditionally thought to be.

  15. Negociando la tierra: empresas extranjeras, minería a gran escala y derechos humanos en Colombia

    Directory of Open Access Journals (Sweden)

    Juan David Velasco


    Full Text Available La adquisición masiva de tierras por parte de empresas extranjeras en países africanos, asiáticos y latinoamericanos refleja una nueva fase del capitalismo global (Sassen, 2013. Colombia no ha escapado a esta lógica mundial del capitalismo, pues en la última década la influencia de las empresas extranjeras en el mercado de tierras ha sido notoria. En esa lógica, este artículo compara, desde un enfoque de Derechos Humanos, las prácticas de adquisición de tierras de tres compañías extranjeras que han explotado carbón a cielo abierto en La Guajira y Cesar. Los resultados indican que la formalidad de la propiedad agraria y las restricciones institucionales de las empresas —asociadas al gobierno corporativo, la participación en bolsa de valores y el veto de compradores internacionales—influyen significativamente en el respeto a los derechos humanos.

  16. Seguimiento al comportamiento del mercado de tierras rurales a través de un GIS, Santander Colombia

    Directory of Open Access Journals (Sweden)

    Ricardo Lozano-Botache


    Full Text Available A pesar de los marcos legales y políticas públicas, en algunos países, los derechos de propiedad sobre la tierra siguen siendo usurpados o impedidos con métodos violentos. Este trabajo de investigación, desde el marco de referencia de la Administración de Tierras, el Neoinstitucionalismo y las herramientas computacionales –conocidas genéricamente como Sistemas de Información Geográfica (GIS, por sus siglas en inglés– presenta un modelo de observación regional de precios que, por la secuencia de datos y su proceso informático, puede mantenerse a través del tiempo como referente en procesos agrarios de restitución de tierras a víctimas del despojo, así como en la ejecución de proyectos de desarrollo social o económico.

  17. The perceived image of Tierra del Fuego (Argentina in travel stories published by “TravelPod”

    Directory of Open Access Journals (Sweden)

    Patricia Andrea Mosti


    environmental conditions, with inhospitable landscapes and, by all appearances, a pristine ecosystem. Together these things form a constitutive part the territorial identity of southern Patagonia. The cartography, the scientific expeditions, the religious missions, the journalism and the literature played an important role in the diffusion and permanency of these representations. In modern Western societies, companies have positioned the concept as a powerful tourist resource, capable of motivating travelers coming to Tierra del Fuego. The present communication proposes an approximation to the perceived image of Tierra del Fuego, according to tourists’ statements in trip blogs, taking these chronicles from sources posted on the site Travelpod. The aim is to examine the contents of the perceived image and to investigate the ways that the concept “End of the World” is resignified. The tourists’ testimonies appeal always to the idea of the End of the World; these representations can be condensed to two dimensions, the one linked to physical – geographical aspects and another that recreates symbolic contents. In the perceived images of Tierra del Fuego, there is an intermingling of the archaic, the legend and the distance, the impregnable vastness of the nature and the recollection of heroic expeditions.


    Directory of Open Access Journals (Sweden)

    Roger Ricardo Ríos Ramirez


    Full Text Available El objetivo del trabajo fue evaluar las perspectivas hacia la titulación de tierras en la Comunidad Campesina San Juan de Miraflores (CCSJM.El estudio fue de tipo descriptivo, con un diseño no experimental transversal. Se aplicó un cuestionario estructurado para evaluar perspectivas a una muestra de 353 comuneros seleccionados de manera aleatoria, estratificada y proporcional, previa validación de expertos y con una confiabilidad alfa de Cronbach α =  0.944.En la CCSJM, las parcelas no tienen las características necesarias para que la agricultura o ganadería se desarrollen, asimismo la actividad campesina no es la principal actividad económica. Asimismo, los comuneros de la CCSJM muestran una perspectiva favorable hacia la titulación de tierras.Por lo tanto, consideramos imperante el proceso de titulación de tierras y la promoción de opciones laborales distintas a las que usualmente realiza un campesino.


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    Full Text Available Este estudio evalúa dos tecnologías: una físico-química y otra biológica, que buscan eliminar la contaminación por el aceite dieléctrico presente en la tierra Fuller, Buscando con ello gestionar de forma ambientalmente adecuada este residuo peligroso. Para la Tecnología físico-química, se usó hexano como solvente y se alcanzó de manera preliminar remociones del aceite dieléctrico del orden del 87% en la tierra Fuller tratada, con una relación tierra Fuller: solvente de 1:8 p/v, una velocidad de agitación de 100 rpm y un tiempo de contacto de 30 minutos. La calidad del aceite dieléctrico recuperado no es apta para su uso en equipos eléctricos, por su baja rigidez dieléctrica, baja densidad y color desfavorable. La tierra Fuller recuperada alcanzó una densidad aparente de 0.623 gr/ml, una densidad real de 2.231 gr/ml y una porosidad de 72.075 %, lo que indica al menos preliminarmente que dicha tierra está muycercana en sus características físicas a la tierra fuller limpia. Para la tecnología biológica se trató la tierra contaminada en un reactor biológico de tierra activada, evaluando la velocidad de agitación y el tiempo de degradación necesario para alcanzar niveles de contaminación adecuados que permitan disponer el residuo en un relleno sanitario convencional sin riesgo para la salud de los ecosistemas y el ser humano, esta fase aún se encuentra en experimentación y los resultados dependen del análisis cromatográfi co del aceite dieléctrico que permanece en la tierra Fuller tratada, en el cual se hará el seguimiento de 10 especies que son clave dentro de este producto, debido a su cantidad y/o toxicidad , falta comprobar la calidad química de la tierra fuller y del aceite dieléctrico recuperados en el tratamiento físico-químico, y validar el proceso biológico para degradar el aceite dieléctrico.

  20. Método de medición de la resistencia del sistema de puesta a tierra

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    Rafael Maydagán Solés


    Full Text Available Con el objetivo de medir con gran exactitud la resistencia óhmica del sistema de puesta a tierra decentrales eléctricas, subestaciones e industrias sin desenergizar, ni interrumpir en lo más mínimo elproceso normal de producción de dichas instalaciones, se realiza intencionalmente un cortocircuitomonofásico  (capacitivo sólido metálico a tierra en una red trifásica, trifilar, cuyo neutro está aisladode tierra. Por el mencionado cortocircuito circulará a tierra una pequeña corriente capacitiva cuyamagnitud estará por debajo de 10 : 15 A, por lo que será fácilmente medible con un amperímetroconectado a través de un transformador de corriente, al cable que realiza el referido cortocircuito.Entonces a través de un filtro de secuencia cero se obtiene el voltaje de secuencia cero. Así es quecon las magnitudes, medidas en un multímetro digital de potencia: corriente de secuencia cero,voltaje de sec. y potencia de sec. cero y mediante determinadas ecuaciones matemáticas, seobtiene el valor de la resistencia ohmica del sistema de puesta a tierra: Rf.   A single-phase (capacitive, solid, metallic short circuit is intentionally done to earth in a three-phase, three-wire network, whose neutral is insulated from the earth. This is done with a view tomeasure  with  high  accuracy  the  ohmic  resistance  of  the  earthing  system  of  power  stations,substations, and industries without having neither the need to de-energize them nor to interrupt, inthe least, the normal production process of  the said power stations, substations, and industries. Acapacitive current of about 10 15 amperes will  circulate to earth through the above-mentioned shortcircuit. Consequently, this capacitive current may be easily measured with an ammeter connectedthrough a current transformer to the cable making the said short circuit. Then, through a zero-sequence filter, a zero-sequence voltage and a zero-sequence power and through certain

  1. Tierras estatales y desigualdad de género en Uruguay=State lands and gender inequality in Uruguay

    Directory of Open Access Journals (Sweden)

    Paula Florit O`Neill


    Full Text Available Resumen En Uruguay, el Instituto Nacional de Colonización (INC es la institución encargada de la adjudicación de tierra por parte del Estado, orientado a la distribución racional de la tierra y su acceso por parte de la población rural más vulnerable. A partir del año 2005, atravesó una reforma que jerarquizó su rol en las políticas de Estado y gestó un nuevo modelo de adjudicación de tierras: las experiencias asociativas. Ese mismo año, el nuevo gobierno impulsó la transversalización de género en el Estado, impulso que anclara en el INC a partir del 2013. Este artículo analiza desde una perspectiva de género la reforma refundacional y la nueva política de tierras, develando la ceguera de género de la reforma y evidenciando desafíos pendientes para la transversalización de género en el diseño de la principal modalidad de adjudicación de tierras públicas.      Abstract In Uruguay, the National Institute of Colonization is the institution resposible for the adjudication of land by the State, aimed at the rational distribution of land and its access by the most vulnerable rural population. Since 2005, the INC went through a reform that prioritized its role in the policies of the State and created a new model of land adjudication: associative experiences of colonization. In that same year, the new government promoted gender mainstreaming in the State, impulse that took roots in the INC from 2013 onwards. This article analyzes from a gender perspective the refounding reform and the new land policy, unveiling the gender blindness of the reform and highlighting pending challenges for gender mainstreaming in the design of the main public land adjudication modality.

  2. Anal cancer; Cancer du canal anal

    Energy Technology Data Exchange (ETDEWEB)

    Fesneau, M.; Champeaux-Orange, E. [Service de radiotherapie, Centre regional universitaire de cancerologie Henry-S.-Kaplan CHU de Tours, Hopital Bretonneau, 37 - Tours (France); Champeaux-Orange, E. [Service d' oncologie-radiotherapie, Centre hospitalier regional d' Orleans, 45 - Orleans (France); Hennequin, C. [Service de cancerologie-radiotherapie, hopital Saint-Louis, 75 - Paris (France)


    Anal canal epidermoid carcinomas represent 1.2% of digestive cancers and 6% of ano-rectal cancers. For localized diseases, the treatment is based on radiotherapy with or without chemotherapy (5-FU and cisplatin or mitomycin), according to tumour and nodal extension. The recommended treatment dose is 45 Gy in the anal canal, the mesorectum, para-rectal lymph nodes, and inguinal lymph nodes. An additional dose of 15 to 20 Gy is delivered in the initial tumour for good responders. Salvage surgery is necessary in case of poor response. The organs at risk to be considered are bladder, femur heads, small intestine and vulva. The objective of this work is to summarize the epidemiological and radio-anatomic and prognostic characteristics of this tumour. The conformal radiotherapy technique is illustrated by a case report. (authors)

  3. Root Canal Filling after Revascularization/Revitalization. (United States)

    Plascencia, Hugo; Cruz, Álvaro; Díaz, Mariana; Jiménez, Ana Laura; Solís, Rodrigo; Bernal, Cesar

    Revascularization/revitalization therapy is considered an alternative procedure for management of teeth with an immature apex and necrotic pulp, mainly when root development is interrupted in the early phases of formation. However, this clinical treatment protocol should be considered a permanent procedure? A maxillary central incisor with a previous and successful RR treatment was intentionally filled with a biocompatible material with the periapical tissues due to the patient's lack of adherence to the follow-up protocol. The 20-month follow-up showed absence of clinical, radiological and tomographic signs and symptoms of an endodontic re-infection. This case demonstrates that once the increased thickening of the canal walls, incrementing the root length, apical closure and the total resolution of the apical lesion are observed, the main canal of a previously treated tooth with an RR procedure can be filled.

  4. Squamous cell carcinoma of the anal canal.

    LENUS (Irish Health Repository)

    Martin, F T


    Squamous cell carcinoma ofthe anal canal represents 1.5% of all malignancies affectingthe gastrointestinal tract. Over the past 20 years dramatic changes have been seen in both the epidemiological distribution of the disease and in the therapeutic modalities utilised to manage it. CLINICAL MANAGEMENT: Historically abdominoperineal resection had been the treatment of choice with local resection reserved for early stage disease. Work by Nigro et al. has revolutionised how we currently manage carcinoma of the anal canal, demonstrating combined modality chemoradiotherapy as an appropriate alternative to surgical resection with the benefit of preserving sphincter function. Surgery is then reserved for recurrent disease with salvage abdominoperineal resection. This article reviews current literature and highlights the changing therapeutic modalities with selected clinical cases

  5. Neuronal hyperplasia in the anal canal

    DEFF Research Database (Denmark)

    Fenger, C; Schrøder, H D


    In a consecutive series of minor surgical specimens from the anal canal, neuronal hyperplasia was found in nine of 56 haemorrhoidectomy specimens and in four of 23 fibrous polyps. In an additional series of 14 resections of the anal canal, neuronal hyperplasia was present in six cases, of which...... five showed haemorrhoids. In all cases, neuronal hyperplasia was located in the submucosa beneath squamous epithelium and extended over an area from 5 to 12 mm. Immunohistochemically, the foci of hyperplasia were found to consist of both neuronal and Schwann cell components. Staining for vasoactive...... intestinal peptide, neuropeptide Y and calcitonin gene related peptide, did not demonstrate any increased terminal density. It is suggested that anal neuronal hyperplasia in these cases represents an acquired lesion due to local mechanical influence....

  6. The shape of the human lumbar vertebral canal A forma do canal vertebral lombar humano

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    Edmundo Zarzur


    Full Text Available Literature on the anatomy of the human vertebral column characterizes the shape of the lumbar vertebral canal as triangular. The purpose of the present study was to determine the precise shape of the lumbar vertebral canal. Ten lumbar vertebral columns of adult male cadavers were dissected. Two transverse sections were performed in the third lumbar vertebra. One section was performed at the level of the lower border of the ligamenta flava, and the other section was performed at the level of the pedicles. The shape of the lumbar vertebral canal at the level of the pedicles tends to be oval or circular, whereas the shape of the lumbar vertebral canal at the level of the lower border of the ligamenta flava is triangular. Thus, the shape of the human lumbar vertebral canal is not exclusively triangular, as reported in the literature. It is related to the level of the transversal section performed on the lumbar vertebra. This finding should be taken into consideration among factors involved in the spread of solutions introduced into the epidural space.A literatura sobre a anatomia da coluna vertebral descreve como sendo triangular o formato do canal vertebral na região lombar. O objetivo deste estudo é determinar a real forma do canal da coluna vertebral lombar.Dez colunas vertebrais de cadáveres de homens adultos foram dissecadas. Dois cortes transversais foram executados na terceira vértebra lombar. Um corte foi feito no nível das bordas inferiores de dois ligamentos amarelos vizinhos e o outro corte foi transversal, no nível dos pedículos. A forma do canal vertebral variou: no nível dos pedículos ela tende a ser oval ou circular e junto às bordas inferiores dos ligamentos amarelos passa a ser triangular. Portanto, a forma do canal vertebral lombar não é somente triangular; ela depende do nível em que se faz o corte transversal da vértebra. Estes achados devem ser levados em consideração entre os fatores envolvidos na difusão das

  7. Relaciones de género y mercados de derechos de agua y tierra en Chiapas

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    Laura Elena Ruiz Meza


    Full Text Available En este artículo se analizan los elementos de género presentes en los procesos de mercantilización de los derechos agrarios y de agua para regadío en el área de influencia del distrito de riego 101 Cuxtepeques, localizado en la región Frailesca de Chiapas. También se examinan las implicaciones de la instrumentación de las políticas hídricas impulsadas en México, para introducir mecanismos de mercado que incentiven la inversión privada en la reasignación de los derechos al agua y la seguridad en la tenencia de la tierra para las mujeres campesinas. A partir de lo cual se sostiene que, en el marco de las relaciones y estructuras de poder existentes, los mercados de derechos de agua recrean mecanismos de exclusión e inequidad social y de género en los procesos de gestión de los recursos hídricos locales.

  8. Arriendo y desigualdad en las tierras altas de Jujuy (Argentina a fines del siglo XIX

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    Cecilia A. Fandos


    Full Text Available Las estructuras agrarias originadas en los procesos más generales de desarrollo capitalista y de redefinición de los derechos de propiedad del siglo XIX en la provincia argentina de Jujuy, resultaron favorables a la formación de importantes latifundios. La contracara de esa fuerte concentración de tierras fue la existencia de un amplio sector de la sociedad que compartía la condición de arrendatarios. De ahí que en este artículo nos proponemos estudiar a los arrendatarios como productores –la riqueza y los ingresos brutos procedentes de la explotación rural que tenían a su cargo– a fin de indagar su capacidad de remuneración, contrastándolos entre sí y con otras situaciones sociales. Para ello, analizamos dos casos que tratan el asunto de sus relaciones de producción en el arriendo. A partir de fuentes fiscales y censales de la década de 1890 que contienen datos de la actividad agropecuaria y de informes sobre la rentabilidad de los distintos productos de origen agrícola o ganaderos de la misma época, reconstruimos el ingreso bruto de esas unidades para cada uno de los actores involucrados en ellas y analizamos los niveles de desigualdad para ese conjunto social.


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    Noelia I. Paredes


    Full Text Available En el Hemisferio Sur las turberas almacenan grandes cantidades de carbono en el suelo. A pesar de su importancia en el ciclo global del carbono, se sabe poco acerca de los procesos de descomposición y su diversidad fúngica. El presente estudio se realizó para describir la composición de hongos filamen - tosos en dos profundidades de una turbera compacta donde las especies vegetales predominantes son Astelia (Asteliaceae y Donatia (Donatiaceae en Moat, Tierra del Fuego, Argentina. De 48 muestras procesadas, se obtuvieron 338 aislamientos. Mediante el uso de diferentes metodologías de cultivo, a través de observación microscópica y por métodos moleculares identificamos 38 especies fúngicas y 18 géneros de Ascomycetes y Zygomycetes. Los aislamientos de Ascomycetes fueron los más abundantes, con dominancia de Penicillium y Trichoderma . Se describe la composición fúngica y se comparó la diversidad y equitatividad de las especies a dos profundidades de muestreo. No se encontraron diferencias significativas entre la composición de especies, la diversidad y equitatividad. La turbera estudiada es un ecosistema que presenta alta diversidad de especies fúngicas filamentosas, algunas de ellas descritas en otras turberas en todo el mundo.

  10. Justificación curricular de la asignatura Arquitectura de tierra. Caso: Tamaulipas, México

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    Dora Luisa Roux Oropeza


    Full Text Available La globalización y los organismos internacionales hanrevolucionado el funcionamiento de las instituciones de educación superior. Las exigencias actualesimplican, entre otras,la gestión deestudios curriculares bajo paradigmas emergentes que justifiquen programas y planes encaminados a la solución de las problemáticas sociales globales. Tomando como referencia lo anterior, se presentan los resultados del análisis curricular que fundamentó la inclusión de la asignatura Arquitectura de Tierra, en la Facultad de Arquitectura Diseño y Urbanismo en Tamaulipas, México. AbstractGlobalization and international agencies have revolutionized the functioning of institutions of higher education; the requirements to them, involving among others, managing curriculum studies on emerging paradigms that justify programs and planswith responsibility for solving global social problems. With reference to the above, the results of the curriculum analysis that informed the inclusion of the subject Earthen Architecture in the Faculty of Architecture and Urban Design in Tamaulipas, Mexico.

  11. Health at the Extremes. Epidemiological and Sanitary Scene in Tierra del Fuego, 1890-1930

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    Romina Casali


    Full Text Available Objective: To characterize the epidemiological and sanitary conditions of the city of Ushuaia (National Territory of Tierra del Fuego at a key time in its history- a time in which interethnic contact and the consolidation of the Argentine nation-state were intensified as two parallel and related processes. Materials and methods: All death certificates available for the period 1890-1930 were analyzed, as well as relevant government documents and secondary sources in order to ob¬tain the health profile of the city and its relationship with the country in the following aspects: type of epidemiological phase, mortality rates, population structure, and the structure in health¬care. Conclusions: There was a great relevance of infectious diseases, and specially tuberculosis, among the population of the city in general, and among the indigenous and criminal population in particular. This epidemiological profile showed the shortcomings of a national health system that was trying to establish at the time, especially in a region difficult to reach.

  12. Block modeling of crustal deformation in Tierra del Fuego from GNSS velocities (United States)

    Mendoza, L.; Richter, A.; Fritsche, M.; Hormaechea, J. L.; Perdomo, R.; Dietrich, R.


    The Tierra del Fuego (TDF) main island is divided by a major transform boundary between the South America and Scotia tectonic plates. Using a block model, we infer slip rates, locking depths and inclinations of active faults in TDF from inversion of site velocities derived from Global Navigation Satellite System observations. We use interseismic velocities from 48 sites, obtained from field measurements spanning 20 years. Euler vectors consistent with a simple seismic cycle are estimated for each block. In addition, we introduce far-field information into the modeling by applying constraints on Euler vectors of major tectonic plates. The difference between model and observed surface deformation near the Magallanes Fagnano Fault System (MFS) is reduced by considering finite dip in the forward model. For this tectonic boundary global plate circuits models predict relative movements between 7 and 9 mm yr- 1, while our regional model indicates that a strike-slip rate of 5.9 ± 0.2 mm yr- 1 is accommodated across the MFS. Our results indicate faults dipping 66- 4+ 6° southward, locked to a depth of 11- 5+ 5 km, which are consistent with geological models for the MFS. However, normal slip also dominates the fault perpendicular motion throughout the eastern MFS, with a maximum rate along the Fagnano Lake.

  13. Tierras, encomiendas y élites. El caso de Jujuy en el siglo XVII

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    Ferreiro, Juan Pablo


    Full Text Available Not available.

    Este artículo describe y analiza los rasgos característicos y principales del grupo de encomenderos que componían el sector nuclear de la élite jujeña a principios del siglo XVII. Para esto se utilizaron fuentes de diversa índole procedentes del Archivo de Tribunales de Jujuy, entre ellas sobresalen testamentos, dotes, obligaciones de pago y poderes; documentación que por su contenido permite analizar la forma en la que esta élite se constituyó, así como los mecanismos utilizados para acceder y/o conservar un puesto privilegiado en la naciente sociedad jujeña. Desde esta perspectiva se presta particular atención a la dinámica establecida por las redes familiares que sustentan esas posiciones a través de la propiedad o posesión de tierras trabajadas por indios de encomienda, y a su participación activa en el Cabildo local.

  14. Dietary resilience among hunter-gatherers of Tierra del Fuego: Isotopic evidence in a diachronic perspective. (United States)

    Tafuri, Mary Anne; Zangrando, Atilio Francisco Javier; Tessone, Augusto; Kochi, Sayuri; Moggi Cecchi, Jacopo; Di Vincenzo, Fabio; Profico, Antonio; Manzi, Giorgio


    The native groups of Patagonia have relied on a hunter-gatherer economy well after the first Europeans and North Americans reached this part of the world. The large exploitation of marine mammals (i.e., seals) by such allochthonous groups has had a strong impact on the local ecology in a way that might have forced the natives to adjust their subsistence strategies. Similarly, the introduction of new foods might have changed local diet. These are the premises of our isotopic-based analysis. There is a large set of paleonutritional investigations through isotopic analysis on Fuegians groups, however a systematic exploration of food practices across time in relation to possible pre- and post-contact changes is still lacking. In this paper we investigate dietary variation in hunter-gatherer groups of Tierra del Fuego in a diachronic perspective, through measuring the isotopic ratio of carbon (∂13C) and nitrogen (∂15N) in the bone collagen of human and a selection of terrestrial and marine animal samples. The data obtained reveal an unexpected isotopic uniformity across prehistoric and recent groups, with little variation in both carbon and nitrogen mean values, which we interpret as the possible evidence of resilience among these groups and persistence of subsistence strategies, allowing inferences on the dramatic contraction (and extinction) of Fuegian populations.


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    Carolina De Los Santos


    Full Text Available Se presenta la actividad catalítica en la deshidrogenación oxidativa de propano de diferentes fosfatos de tierra rara LnPO 4 (donde Ln = La, Ce, Pr, Nd, Sm y de los mismos soportados sobre una arcilla pilareada con aluminio de alta superficie específica. Los sólidos fueron caracterizados por ATG, DR X, adsorción de nitrógeno y análisis inmediato post reacción para determinar la eventual formación de carbón superficial. Los ensayos catalíticos usando como mezcla de reacción C 3 H 8 /O 2 /Ar = 10/10/80 se hicieron a temperaturas entre 400ºC y 600ºC. Todos los catalizadores fuer on activos. Los principales productos de reacción fueron: H 2 , CO, CO 2 , CH 4 , C 2 H 4 y C 3 H 6 , no detectándose compuestos orgánicos oxigenados. Aunque todos los sistemas investigados fueron activos, los catalizadores soportados sobre PILC-Al presentaron una actividad mayor que los másicos, siendo el mayor efecto para el samario en que el rendimiento a 600oC aumenta del 4% al 10%. Este efecto fue atribuido al incremento en el área superficial específica.

  16. Constitucionalismo verde en Ecuador: Derechos de la Madre Tierra y Buen Vivir

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    José Manuel Velázquez-Gutiérrez


    Full Text Available Ante la situación de la degradación ambiental a nivel global, este artículo ofrece un estudio relacionado con el ambientalismo y el nuevo constitucionalismo latinoamericano. Este trabajo académico es producto de una investigación documental a través del enfoque de la Teoría del Discurso, en el cual se analizan los nuevos paradigmas de los Derechos de la Naturaleza implícitos en la Constitución del Ecuador, específicamente se comparan y revisan los artículos constitucionales relacionados con el tema medioambiental. Con tal propósito se estudia la base teórica y casos similares de otras constituciones andinas para comprender a profundidad la visión holística de conceptos ancestrales como el Buen Vivir y la Madre Tierra, insertados como eje medular de la Carta Magna del Ecuador, como un reflejo biocéntrico que demuestra que existe una alternativa real para la convivencia entre los seres humanos y la naturaleza.

  17. Koebner phenomenon of the ear canal skin.

    LENUS (Irish Health Repository)

    Young, O


    The Koebner phenomenon originally described the appearance of psoriatic lesions in the uninvolved skin of patients with psoriasis as a consequence of trauma. We describe a case of concurrent lichen planus and sarcoidosis in the auditory canal, which represents an unusual manifestation of the Koebner phenomenon. This is the first case of concurrent lichen planus and sarcoidosis in the head and neck region and highlights the need for biopsy to allow accurate histopathological diagnosis and treatment.

  18. Koebner phenomenon of the ear canal skin.

    LENUS (Irish Health Repository)

    Young, O


    The Koebner phenomenon originally described the appearance of psoriatic lesions in the uninvolved skin of patients with psoriasis as a consequence of trauma. We describe a case of concurrent lichen planus and sarcoidosis in the auditory canal, which represents an unusual manifestation of the Koebner phenomenon. This is the first case of concurrent lichen planus and sarcoidosis in the head and neck region and highlights the need for biopsy to allow accurate histopathological diagnosis and treatment.

  19. Root canal filling using Resilon: a review.

    LENUS (Irish Health Repository)

    Shanahan, D J


    Root canal treatment is achieved by chemo-mechanical debridement of the root canal system followed by filling. The filling material \\'entombs\\' residual bacteria and acts as a barrier which prevents the entrance of oral microorganisms and reinfection of the root canal system through microleakage. However, filling with contemporary root filling materials such as gutta-percha offers limited long-term resistance to microorganisms; as a result other materials such as Resilon have been investigated as alternatives. The aim of this review was to analyse the literature to consider whether Resilon is a suitable root canal filling material. A MEDLINE and Cochrane library search including various keyword searches identified several papers which investigated or discussed Resilon or RealSeal\\/Epiphany. Analysis of the literature demonstrated that the bulk of the literature is in vitro in nature, based largely on leakage-type studies, and demonstrates a wide variety of methodologies with conflicting findings; as a result meaningful conclusions are difficult. Within the limit of these in vitro studies Resilon appears to perform adequately in comparison to gutta-percha, however, as a result of the questionable merit of such studies, it cannot presently be considered an evidence-based alternative to the current gold standard gutta-percha. It is imperative that before Resilon is considered as a replacement material, a better understanding of the physical properties of the resin sealer and the reality of the adhesive \\'monoblock\\' are elucidated. The literature also demonstrates a paucity of quality long-term clinical outcome studies which will need to be addressed before firm conclusions can be reached.

  20. Carotid canal dehiscence in the human skull

    Energy Technology Data Exchange (ETDEWEB)

    Pastor Vazquez, J.F.; Gil Verona, J.A. [Department of Anatomy, Faculty of Medicine, University of Valladolid, Ramon y Cajal, 7, E-47005 Valladolid (Spain); Garcia Porrero, M. [Department of Radiology, Faculty of Medicine, University of Valladolid (Spain)


    Abnormalities of the floor of the carotid canal have been studied in 538 skulls. These abnormalities range from a fissure to total absence of the floor. This variation may be caused by abnormalities of the internal carotid artery or deficiencies in ossification of the skull base. CT suggests that these changes should be taken into account by surgeons working on the skull base. (orig.) With 4 figs., 8 refs.

  1. Roentgenographic study of the mandibular canal

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Hyung Kyu [Dept. of Oral Radiology, College of Dentistry, Seoul National University, Seoul (Korea, Republic of)


    The mandibular canal must be considered carefully during the surgical treatment, especially surgical extraction of the impacted tooth and intraosseous implant, because it contains the important inferior alveolar nerve and vessels. The author investigated the curvature of the mandibular canal and its relation to the mandibular molars and positional relation between the mental foramen and the mandibular premolars in orthopantomogram. The materials consisted of 441 orthopantomograms divided four groups; Group I consisted of 56 males and 44 females from 1 to 6 years of age, Group II consisted of 58 males and 45 females from 7 to 12 years of age, Group III consisted of 65 males and 33 females from 13 to 18 years of age, Group IV consisted of 86 males and 54 females over 19 years of age. The results were as followings; 1. The curvature of mandibular canal was 144.50 .deg. in Group II, 148.11 .deg. in Group III, 147.33 .deg. in Group IV. 2. The curvature of mandibular canal was located most frequently on the area between mandibular 1st molar and mandibular 2nd molar in Group I (42%) and on the mandibular 2nd molar area in Group II (54%), Group III (59%), Group IV (53%). 3. The position of mental foramen was most frequently below the mandibular 1st premolar in Group I (58%), between the mandibular 1st premolar and the 2nd premolar in Group II (62%), Group III (47%), and below the mandibular 2nd premolar in Group IV (58%).

  2. Lesions in the external auditory canal

    Directory of Open Access Journals (Sweden)

    Priyank S Chatra


    Full Text Available The external auditory canal is an S- shaped osseo-cartilaginous structure that extends from the auricle to the tympanic membrane. Congenital, inflammatory, neoplastic, and traumatic lesions can affect the EAC. High-resolution CT is well suited for the evaluation of the temporal bone, which has a complex anatomy with multiple small structures. In this study, we describe the various lesions affecting the EAC.

  3. Tierras de la microcuenca potrerillo (Cauca, Colombia: Clasificación local en relación con propiedades edáficas.

    Directory of Open Access Journals (Sweden)

    Cerón Rengifo Carmen Patricia


    Full Text Available Este estudio se realizó con el objetivo de relacionar la clasificación local de tierras con propiedades físicas, químicas y biológicas del suelo. Se hicieron entrevistas a 36 agricultores de la microcuenca, Potrerillo, Cauca, Colombia, para considerar criterios culturales de clasificación local; se tomaron muestras de suelo en 8 tierras, de 0 a 5 y 0 a 20 cm, con 5 repeticiones. Se determinó color, textura, N y P disponible, C total, fracción liviana de materia orgánica (LL, PH, Ca, K, Mg y Al. Los datos se trabajaron estadísticamente a partir de análisis de varianza, prueba Duncan y análisis de clasificación de datos. La información sugiere que los agricultores diferencias las tierras a partir de la ubicación, características físicas del suelo y de categorías culturales llamadas tierra buena, mala, brava y cansada. Las tierras consideradas buenas se relacionan con colores pardos oscuros, contenidos más altos de N, C y fracción LL, mayor densidad de miriápodos en tierras con vegetación arbórea y mayor biomasa de lombrices en barbecho de la parte baja de la colina. Entre las tierras de menor calidad, disminuye N, C fracción LL y Al y aumenta el pH; en aquellas que no son utilizadas son frecuentes los colores amarillos o rojos, decrecen los valores de N, C, LL, Ph y se incrementa el Al.

  4. [Preliminary research of Er:YAG laser used for pulpotomy of Beagle dogs]. (United States)

    Guo, Y D; Zhang, S


    To investigate the effects of erbium:yttrium aluminium garnet (Er:YAG)laser irradiation on pulp and formation of dentin bridge. The beagle dogs' coronal pulp is amputated by Er:YAG laser. In the study, 24 premolar teeth of two one-year-old Beagle dogs were used. They were divided into 3 groups: bur group, 200 mJ laser group,100 mJ laser group. The coronal pulp were removed by traditional bur or 200 mJ/20 Hz or 100 mJ/20 Hz Er:YAG laser. Then, they were dressed with mineral trioxide aggregate (MTA) and sealed with resin. Clinical, radiological and histological analyses were performed 1 day, 2 weeks, 4 weeks and 8 weeks after treatment. The mobility and gingiva situation were evaluated for clinical evaluation. Periapical films were used for radiological evaluation. The extracted teeth were preserved in 10% formalin. After decalcification, tissue processing, paraffin embedding, serial sectioning at 5 μm thickness, staining (Hematoxylin and Eosin, HE), the samples were assessed by an independent observer for calcified bridge formation and radicular pulp inflammation. The mean thickness of dental bridge was measured if there was complete dental bridge. Clinical evaluation: there were no signs of fistula or mobility or any abnormal symptoms in Er:YAG laser groups and bur group during the observation period. Radiological evaluation: there were no signs of widened periodontal ligament or root absorption or periapical radiolucency in Er:YAG laser groups and bur group. Histological evaluation: there was no severe inflammation reaction in 200 mJ/20 Hz, 100 mJ/20 Hz Er:YAG laser groups and bur group 1 day, 2 weeks, 4 weeks, 8 weeks post-operation in Hematoxylin and Eosin staining. A complete dentin bridge could be observed in 200 mJ/20 Hz, 100 mJ/20 Hz Er:YAG laser groups, while no complete dentin bridge in bur group 2 weeks post-operation. Complete dental bridge could be observed in each group 4 and 8 weeks post-operation. The mean thickness of dental bridge 4 weeks post

  5. Semiconductor laser irradiation improves root canal sealing during routine root canal therapy. (United States)

    Su, Dandan; Hu, Xingxue; Wang, Dashan; Cui, Ting; Yao, Ruyong; Sun, Huibin


    To evaluate the effect of semiconductor laser irradiation on root canal sealing after routine root canal therapy (RCT). Sixty freshly extracted single-rooted human teeth were randomly divided into six groups (n = 10). The anatomic crowns were sectioned at the cementoenamel junction and the remaining roots were prepared endodontically with conventional RCT methods. Groups A and B were irradiated with semiconductor laser at 1W for 20 seconds; Groups C and D were ultrasonically rinsed for 60 seconds as positive control groups; Groups E and F without treatment of root canal prior to RCT as negative control groups. Root canal sealing of Groups A, C and E were evaluated by measurements of apical microleakage. The teeth from Groups B, D and F were sectioned, and the micro-structures were examined with scanning electron microscopy (SEM). One way ANOVA and LSD-t test were used for statistical analysis (α = .05). The apical sealing of both the laser irradiated group and the ultrasonic irrigated group were significantly different from the control group (p0.5). SEM observation showed that most of the dentinal tubules in the laser irradiation group melted, narrowed or closed, while most of the dentinal tubules in the ultrasonic irrigation group were filled with tooth paste. The application of semiconductor laser prior to root canal obturation increases the apical sealing of the roots treated.

  6. Semiconductor laser irradiation improves root canal sealing during routine root canal therapy.

    Directory of Open Access Journals (Sweden)

    Dandan Su

    Full Text Available To evaluate the effect of semiconductor laser irradiation on root canal sealing after routine root canal therapy (RCT.Sixty freshly extracted single-rooted human teeth were randomly divided into six groups (n = 10. The anatomic crowns were sectioned at the cementoenamel junction and the remaining roots were prepared endodontically with conventional RCT methods. Groups A and B were irradiated with semiconductor laser at 1W for 20 seconds; Groups C and D were ultrasonically rinsed for 60 seconds as positive control groups; Groups E and F without treatment of root canal prior to RCT as negative control groups. Root canal sealing of Groups A, C and E were evaluated by measurements of apical microleakage. The teeth from Groups B, D and F were sectioned, and the micro-structures were examined with scanning electron microscopy (SEM. One way ANOVA and LSD-t test were used for statistical analysis (α = .05.The apical sealing of both the laser irradiated group and the ultrasonic irrigated group were significantly different from the control group (p0.5. SEM observation showed that most of the dentinal tubules in the laser irradiation group melted, narrowed or closed, while most of the dentinal tubules in the ultrasonic irrigation group were filled with tooth paste.The application of semiconductor laser prior to root canal obturation increases the apical sealing of the roots treated.

  7. Comparison of Bacterial Leakage between 3 Different Root Canal Obturation Techniques in Oval Shaped Canals

    Directory of Open Access Journals (Sweden)

    Eshagh-ali Saberi


    Full Text Available Introduction: The purpose of this study was to evaluate the sealing ability of 3 obturation techniques in oval-shaped canals by bacterial leakage assessment. Methods: Sixty mandibular incisors with oval canals were selected after providing buccolingual and mesiodistal radiographs. The teeth were sectioned at a 10 mm distance from the apex. After instrumentation, the teeth were divided into 3 groups and the canals in the three groups were obturated with lateral condensation (G1, warm vertical condensation (G2 and thermoplasticized injectable gutta percha (G3. The teeth were exposed to human saliva. Observing the turbidity of the BHI broth for a period of 63 days the number of days required for the complete contamination of root canals was recorded. The data were analyzed using descriptive statistical methods and Kruskal-Wallis test with SPSS statistical software. Results: Warm vertical condensation (G2 needed a significantly greater average time for leakage than the two other methods. No significant differences were found between lateral condensations and thermoplasticized injectable G.P techniques. Conclusion: warm vertical condensation provides a better seal against bacterial leakage than lateral condensation and obtura II method in obturating oval-canals.

  8. Anterior canal lithiasis: diagnosis and treatment. (United States)

    Casani, Augusto Pietro; Cerchiai, Niccolò; Dallan, Iacopo; Sellari-Franceschini, Stefano


    To describe the clinical and oculographic features in patients with anterior semicircular canal benign paroxysmal positional vertigo and to determine the efficacy of a canalith repositioning procedure for its management. Case series with chart review of patients presenting positional vertigo and positional downbeating nystagmus during a 2-year period. Outpatients' tertiary referral center for balance disorders. Eighteen patients suffering from positional vertigo and presenting positional downbeating nystagmus were treated with a maneuver based on a modification of the procedure proposed by Crevits. disappearance of positional downbeating nystagmus. Positional downbeating nystagmus was elicited unilaterally with the Dix-Hallpike maneuver in 6 cases. In 4 patients, it was triggered by both left and right Dix-Hallpike tests. In 8 patients, the positional nystagmus was elicited by a straight head-hanging maneuver. The positional nystagmus was purely downbeating in 12 patients. In the remaining, a torsional component was detected. After the treatment, only 1 patient showed positional nystagmus at 30 days. In anterior canal benign paroxysmal positional vertigo, the presence of a positional downbeating nystagmus in response to positional tests is key for diagnosis. In a significant number of patients, the affected side may not be detected because of the inconstant presence of a torsional component. Treatment with a simplified maneuver based on Crevits's technique can be considered an effective method for the treatment of anterior canal lithiasis, especially when the affected side cannot be detected clearly.

  9. Differences between acceleromyography and electromyography during neuromuscular function monitoring in anesthetized Beagle dogs. (United States)

    Sakai, Daniel M; Martin-Flores, Manuel; Tomak, Emily A; Martin, Matthew J; Campoy, Luis; Gleed, Robin D


    Quantitative neuromuscular monitoring is essential for studies of potency and duration of neuromuscular blocking agents, and for detecting residual paralysis in anesthetized patients. This investigation evaluates whether there are systematic differences between acceleromyography (AMG) and electromyography (EMG); two quantitative methods for monitoring neuromuscular block. Prospective. Ten healthy Beagle dogs. Dogs were anesthetized with isoflurane and dexmedetomidine. Both ulnar nerves were stimulated with a train-of-four (TOF) pattern every 15 seconds. The magnitude of the first twitch (T1) and the TOF ratio (magnitude of T4/T1; TOFR) were quantified simultaneously with AMG and EMG, applied randomly to each extremity. The extent of maximal block (T1 depression) and onset time were measured by AMG and EMG during TOF monitoring after the administration of cisatracurium (0.05 mg kg(-1)). In addition, recovery of T1 to 25% and 75%, the recovery index (time between T1 of 25% and 75%), and recovery of the TOFR to 0.9 were used to characterize recovery from cisatracurium and were compared between monitors. Regression and Bland-Altman plots for T1 and TOFR were also created. Maximal block and onset time were not different between monitors. Time to recovery of T1 to 25% and 75%, and time to TOF ratio 0.9 was significantly shorter with AMG. The recovery index was not different between monitors. When the TOFR returned to 0.9 with AMG, EMG still measured considerable residual block (TOFR 0.47). Electromyography consistently detected residual NMB when recovery from NMB was complete as assessed by AMG. © 2014 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.

  10. Ocular Distribution and Pharmacokinetics of Lifitegrast in Pigmented Rabbits and Mass Balance in Beagle Dogs. (United States)

    Chung, Jou-Ku; Spencer, Elizabeth; Hunt, Matthew; McCauley, Thomas; Welty, Devin

    Lifitegrast is approved in the United States for the treatment of dry eye disease (DED). We assessed lifitegrast's ocular distribution/pharmacokinetic profile in rabbits, and 14 C-lifitegrast mass balance/excretion in dogs. Female pigmented rabbits received a single topical ocular dose of lifitegrast (Formulation No. 1, n = 25; No. 2, n = 25) per eye twice daily (target, 1.75 mg/eye/dose). Blood/ocular tissues were collected on day 5. Beagle dogs received single intravenous (n = 10; target, 3 mg, 262 μCi/animal) and ocular (n = 8, target, 3 mg, 30 μCi/eye) doses of 14 C-lifitegrast (∼8 weeks between doses). Blood, excreta, and cage rinse/wipes were collected. Concentrations were measured by mass spectrometry/liquid scintillation counting. Pharmacokinetic analyses (noncompartmental) included maximum concentration (C max ), time to C max (t max ), and area under the concentration-time curve from 0 to 8 h (AUC 0-8 ). In rabbits, lifitegrast C max and AUC 0-8 were similar between formulations. C max was highest in ocular anterior segment tissues: 5,190-14,200 ng/g [conjunctiva (palpebral/bulbar), cornea, anterior sclera]. Posterior segment tissues had lower concentrations (0-826 ng/g). AUC 0-8 followed a similar trend. Plasma concentrations were low (C max lifitegrast was eliminated primarily through feces. Excreted radioactivity was mainly unchanged lifitegrast. High exposure of lifitegrast in rabbit ocular anterior segment tissues and low exposure in posterior segment tissues/plasma suggests that lifitegrast reaches target tissues for DED treatment, with low potential for off-target systemic/ocular effects. Excretion of unchanged 14 C-lifitegrast suggests minimal drug metabolism in vivo. This is consistent with lifitegrast clinical trial efficacy/safety data.

  11. Prussian blue decorporation of {sup 137}Cs in humans and beagle dogs

    Energy Technology Data Exchange (ETDEWEB)

    Melo, D.R.; Lipsztein, J.L.; Oliveira, C.A.N.; Lundgren, D.L.; Muggenburg, B.A.; Guilmette, R.A


    Prussian blue was used to enhance the elimination of {sup 137}Cs from 46 individuals contaminated in an accident in Goiania, Brazil, in 1987. PB dosages administered to the victims varied from 1 to 3 g.d{sup -1} for children and from 3 to 10 g.d{sup -1} for adolescents and adults. To complement human data in the evaluation of the effectiveness of PB and its relation to age, a 41 day study was conducted using immature (4.7 months old), young adult (2.4 years old) and aged (13.5 years old) male beagle dogs. The mean biological half-times for the Goiania people under PB treatment were 24 {+-} 3 days, 30 {+-} 12 days and 25 {+-} 11 days, for children, adolescents and adults, respectively. The mean reductions of half-times were 43%, 46% and 69%, respectively. The effect of PB was shown to be independent of age and the administered dose. Similar results were found in dogs: the mean biological half-times related to the second component of the equation were 11, 15 and 13 days for the immature, young adult and aged dogs, respectively, indicating a reduction of the clearance half-times of 45%, 45% and 63%. The experiment in dogs has shown that when the PB is administered immediately after caesium intake, its effectiveness is greater in immature than in aged dogs. The percentages of the initial body burden remaining 41 days after caesium intake were 4%, 12% and 8% for the immature, young adult and aged dogs, respectively. This age-related effect correlates with the increased fraction of {sup 137}Cs eliminated with the fast clearance half-time, and was greater in immature than in aged dogs. (author)

  12. [Tolerance studies of an intravenous fat emulsion (FE-S15) with beagle dogs]. (United States)

    Reimold, E W; Ruff, P A; Davis, T R


    The potential toxicity of FE-S15, a soybean oil fat emulsion used in parenteral nutrition, was studied in dogs. Forty pure bred beagles, divided into two experimental groups (FE-S15 at 9 and 4 gm/kg BW/day) and two corresponding control groups (receiving Dextrose Ringer's Solution) were given daily infusions for 28 days via a central venous catheter. When compared with control groups no significant weight loss was observed in either experimental group; the food intake decreased only in animals receiving fat in high doses. Hemoglobin and hematocrit decreased in all groups, the greatest fall observed in the group receiving high dose fat infusion was the hematocrit decline from 43.9% to 31%. This decrease was significantly different from the control only during one observation period. The total serum lipids, triglyceride and phospholipid concentrations of the animals receiving fat in high doses increased 3-4 times in comparison to that of the control group; cholesterol increased 5 times. The serum protein level fell from 6.5 to 5.1 gm/dl in animals receiving 9 gm/kg BW/day while animals receiving 4 gm/kg BW/day had a significant increase to 8.4 gm/dl. Except for an overall decreased activity clinical sign such as lethargy, loss of appetite, vomiting, and diarrhea were infrequent and equally observed in experimental and control animals. The post mortem examination did not reveal changes that must be attributed to the administered fat. It is concluded that the fat emulsion FE-S15 is fairly well tolerated in dogs at a potentially toxic level.

  13. Pharmacokinetics, bioavailability and PK/PD relationship of cefquinome for Escherichia coli in Beagle dogs. (United States)

    Zhou, Y F; Zhao, D H; Yu, Y; Yang, X; Shi, W; Peng, Y B; Liu, Y H


    The pharmacokinetics and bioavailability of cefquinome in Beagle dogs were determined by intravenous (IV), intramuscular (IM) or subcutaneous (SC) injection at a single dose of 2 mg/kg body weight (BW). The minimum inhibitory concentrations (MIC) of cefquinome against 217 Escherichia coli isolated from dogs were also investigated. After IV injection, the plasma concentration-time curve of cefquinome was analyzed using a two-compartmental model, and the mean values of t1/2α (h), t1/2β (h), Vss (L/kg), ClB (L/kg/h) and AUC (μg·h/mL) were 0.12, 0.98, 0.30, 0.24 and 8.51, respectively. After IM and SC administration, the PK data were best described by a one-compartmental model with first-order absorption. The mean values of t1/2Kel , t1/2Ka , tmax (h), Cmax (μg/mL) and AUC (μg·h/mL) were corresponding 0.85, 0.14, 0.43, 4.83 and 8.24 for IM administration, 0.99, 0.29, 0.72, 3.88 and 9.13 for SC injection. The duration of time that drug levels exceed the MIC (%T > MIC) were calculated using the determined MIC90 (0.125 μg/mL) and the PK data obtained in this study. The results indicated that the dosage regimen of cefquinome at 2 mg/kg BW with 12-h intervals could achieve %T > MIC above 50% that generally produced a satisfactory bactericidal effect against E. coli isolated from dogs in this study. © 2015 John Wiley & Sons Ltd.

  14. The Beagle 2 Stereo Camera System: Scientific Objectives and Design Characteristics (United States)

    Griffiths, A.; Coates, A.; Josset, J.; Paar, G.; Sims, M.


    The Stereo Camera System (SCS) will provide wide-angle (48 degree) multi-spectral stereo imaging of the Beagle 2 landing site in Isidis Planitia with an angular resolution of 0.75 milliradians. Based on the SpaceX Modular Micro-Imager, the SCS is composed of twin cameras (with 1024 by 1024 pixel frame transfer CCD) and twin filter wheel units (with a combined total of 24 filters). The primary mission objective is to construct a digital elevation model of the area in reach of the lander’s robot arm. The SCS specifications and following baseline studies are described: Panoramic RGB colour imaging of the landing site and panoramic multi-spectral imaging at 12 distinct wavelengths to study the mineralogy of landing site. Solar observations to measure water vapour absorption and the atmospheric dust optical density. Also envisaged are multi-spectral observations of Phobos &Deimos (observations of the moons relative to background stars will be used to determine the lander’s location and orientation relative to the Martian surface), monitoring of the landing site to detect temporal changes, observation of the actions and effects of the other PAW experiments (including rock texture studies with a close-up-lens) and collaborative observations with the Mars Express orbiter instrument teams. Due to be launched in May of this year, the total system mass is 360 g, the required volume envelope is 747 cm^3 and the average power consumption is 1.8 W. A 10Mbit/s RS422 bus connects each camera to the lander common electronics.

  15. Development of stabilized tenofovir disoproxil tablet: degradation profile, stabilization, and bioequivalence in beagle dogs. (United States)

    Oh, Ga-Hui; Kim, Joo-Eun; Park, Young-Joon


    The purpose of this study was to develop a hydrolysis-resistant optimized oral formulation of tenofovir disoproxil (TD) using a stabilizer. To develop a stabilized TD tablet bioequivalent to the commercial TD fumarate (TDF, Viread ® ) tablet, TD free base was prepared and its degradation profile and stability were investigated. The TD tablet showed antiviral activity, but its absorption was limited in the intestinal tract because of premature degradation. The drug subjected to severe conditions for the stress test was catalyzed under neutral, basic, oxidative, and thermolytic conditions, whereas it was comparatively stable under acidic, photolytic, and humid states. The compatibility study showed that sodium bisulfite (SB) stabilized TD by preventing its degradation in aqueous and 3% peroxide solutions compared with the unstabilized TD. According to the stability analysis and degradation profile, four TD tablet formulations were prepared. The selected TD tablets were composed of non-hygroscopic excipients (lipophilic-fumed silica, anhydrous lactose, and microcrystalline cellulose [MCC]), SB, croscarmellose sodium (CCS), and hydrogenated castor oil (HCO), and were manufactured using a dry granulation method because of their hydrolytic properties. The stabilized TD tablet showed similar dissolution properties as the TDF (Viread ® ) reference tablet in pH 1.2, 4.0, and 6.8 and water. Moreover, the lower degradation rate of the tablet in simulated gastrointestinal fluid demonstrated that its intestinal absorption might have improved owing to prevention of its enzymatic hydrolysis and the pH effect. Finally, the formulated TD tablet was bioequivalent to the TDF (Viread ® ) reference tablet in beagle dogs.

  16. Respiratory mechanics: comparison of Beagle dogs, Göttingen minipigs and Cynomolgus monkeys. (United States)

    Truchetti, Geoffrey; Troncy, Eric; Robichaud, Annette; Gold, Leslie; Schuessler, Thomas; Maghezzi, Said; Bassett, Leanne; Authier, Simon


    When the no observed adverse effect level (NOAEL) is determined by respiratory safety pharmacology, follow-up studies are warranted and may include airway resistance and compliance. Respiratory mechanics in commonly used large animal species (Beagle dogs, Cynomolgus monkeys, and Göttingen minipigs) were compared. Eighteen animals were used (3/sex/species) in an anesthetized model (propofol infusion) with pancuronium as a neuromuscular blocker. Parameters of respiratory mechanics were evaluated at baseline and at peak drug effect. Resistance (Rrs) and elastance (Ers) were measured by applying a single frequency forced oscillation (0.5 Hz) to the subject's airway opening and fitting the flow, volume and pressure data to the single compartment model of the lung. Increasing doses of intravenous (IV) methacholine were administered in all three species, as well as doubling aerosolized concentrations of the same bronchoconstrictor agent before and after inhaled albuterol. The slope of the IV methacholine dose-response curve for Rrs was similar in dogs and monkeys and both species differed from minipigs, which showed greater reactivity. At the highest IV dose tested, minipigs also reached higher levels of bronchoconstriction than the other two species. They were followed, in decreasing order, by dogs and monkeys. Albuterol induced a significant decrease in the slope of the dose-response curve only in dogs and monkeys. Scientific literature is available on respiratory mechanics in monkeys and dogs but not in minipigs. Our results suggest that minipigs were more reactive than dogs and monkeys to IV methacholine while less sensitive to inhaled albuterol. Copyright © 2014 Elsevier Inc. All rights reserved.

  17. Inhibition of hepatobiliary transporters by a novel kinase inhibitor contributes to hepatotoxicity in beagle dogs. (United States)

    Daniels, John Scott; Lai, Yurong; South, Sarah; Chiang, Po-Chang; Walker, Daniel; Feng, Bo; Mireles, Rouchelle; Whiteley, Laurence O; McKenzie, Jeremy W; Stevens, Jeffrey; Mourey, Robert; Anderson, David; Davis Ii, John W


    PF-022 (1) is a novel polycyclic benzothiophene kinase inhibitor selective for mitogen-activated protein kinase-activated protein kinase 2 (MK2). Compound 1 emerged as an inhibitor bearing submicromolar potency against MK2 (IC50 5 nM) and demonstrated projected human pharmacokinetics sufficient for oral dosing. However, following a single, oral administration of 1 to beagle dogs, animals experienced an acute liver injury characterized by increases in biomarkers associated with hepatotoxicity; particularly noteworthy was the reversible elevation in bile salts and total bilirubin. Accompanying this observation was an ADME appraisal which included hepatic bioactivation of 1 in multiple species and the in vitro inhibition of P-glycoprotein (P-gp; IC50 21 μM). Simply attenuating the bioactivation via structural modification proved ineffective in improving the in vivo tolerability of this polycyclic scaffold. Hence, disruption of hepatobiliary transporters by the compound series was hypothesized as the likely mechanism contributing to the acute hepatotoxicity. Indeed, closer in vitro examination employing transporter gene overexpressing MDCK cell lines and membrane vesicles revealed potent compound-dependent inhibition of human multi-drug resistance-associated protein 2 (MRP2/ABCC2; IC50 38 μM) and bile salt export pump (BSEP/ABCB11; IC50 10 μM), two crucial hepatobiliary transport proteins accountable for bilirubin and bile salt homeostasis, respectively. Subsequent introduction of pKa-altering modifications to a second generation compound PF029 proved successful in reducing its affinity for these key efflux transporters (MRP2 IC50 >80 μM; BSEP IC50 > 70 μM; P-gp > 90 μM), consequently mitigating this overt organ toxicity in dogs.

  18. Raw beef bones as chewing items to reduce dental calculus in Beagle dogs. (United States)

    Marx, F R; Machado, G S; Pezzali, J G; Marcolla, C S; Kessler, A M; Ahlstrøm, Ø; Trevizan, L


    Evaluate the effect of raw bovine cortical bone (CB) (medullary bone cross-sectioned) and marrow or epiphyseal 'spongy' bone (SB) as chew items to reduce dental calculus in adult dogs. Eight 3-year-old Beagle dogs were observed in two study periods. In the first study, the dogs each received a piece of bovine femur CB (122 ± 17 g) daily and in the second study, a piece of bovine femur SB (235 ± 27 g). The first study lasted 12 days and the second 20 days. Dental calculus was evaluated using image integration software. At the start of the studies, dental calculus covered 42.0% and 38.6% of the dental arcade areas, respectively. In study one, the chewing reduced the established dental calculus area to 27.1% (35.5% reduction) after 3 days and after 12 days the dental calculus covering was reduced to 12.3% (70.6% reduction). In study two, the dental calculus covered 16.8% (56.5% reduction) after 3 days, 7.1% (81.6% reduction) after 12 days and 4.7% (87.8% reduction) after 20 days. The CB remained largely intact after 24 h, but SB was reduced to smaller pieces and in some cases totally consumed after 24 h. No complications such as tooth fractures, pieces of bone stuck between teeth or intestinal obstructions were observed during the studies. Chewing raw bovine bones was an effective method of removing dental calculus in dogs. The SB bones removed dental calculus more efficiently in the short term. © 2016 Australian Veterinary Association.

  19. Use of the carbon dioxide laser in guided tissue regeneration wound healing in the beagle dog (United States)

    Rossmann, Jeffrey A.; Parlar, Ates; Abdel-Ghaffar, Khaled A.; El-Khouli, Amr M.; Israel, Michael


    The concept of guided tissue regeneration (GTR) allowing cells from the periodontal ligament and alveolar bone to repopulate the treated root surface has shown the ability to obtain periodontal new attachment. Healing studies have also shown that conventional GTR therapy still does not exclude all the epithelium. This epithelial proliferation apically interferes with the establishment of the new connective tissue attachment to the root surface. The objective of this research study was to examine whether controlled de-epithelialization with the carbon dioxide laser during the healing phase after periodontal surgery, would retard the apical migration of the epithelium and thereby enhance the results obtained through guided tissue regeneration. Eight beagle dogs were used, the experimental side received de-epithelialization with the CO2 laser in conjunction with flap reflection and surgically created buccal osseous defects. Selected defects on each side were treated with ePTFE periodontal membranes. The laser de-epithelialization was repeated every 10 days until removal of the membranes. The control side received the same surgical treatment without laser application. This experimental design allowed histologic study of the new attachment obtained in defects treated with flap debridement with or without laser de-epithelialization and with or without ePTFE membranes. A statistical analysis was performed on the histometric data from 48 teeth in the 8 dogs after 4 months of healing. The results showed significant amounts of new attachment obtained from all four treatment modalities with no statistically significant differences for any one treatment. However, the trend towards enhanced regeneration with the combined treatment of laser and membrane vs. membrane alone or debridement alone was evident. The histologic analysis revealed a significant amount of newly formed `fat cementum' seen only on the laser treated teeth. This feature was the most remarkable finding of the

  20. Dose-dependent emetic effects of the Amaryllidaceous alkaloid lycorine in beagle dogs. (United States)

    Kretzing, Sascha; Abraham, Getu; Seiwert, Bettina; Ungemach, Fritz Rupert; Krügel, Ute; Regenthal, Ralf


    Ingestions of plant material from Amaryllidaceae, especially the bulbs of daffodils, are known to be toxic, representing a persistent cause of poisoning in human and animals. Empiric data from case reports suggested, that the alkaloid lycorine could be the toxic constituent of the multi-component mixture responsible for symptoms like nausea and emesis. Systematic studies of the in vivo effects of the amaryllidaceaeous-type alkaloids are not available. Therefore, in an open, prospective, randomized and controlled trial we studied the dose-effect relationship of lycorine-induced nausea and emesis and the toxicokinetics of lycorine in beagle dogs. Subcutaneously administered lycorine-induced nausea and emesis starting at 0.5 mg/kg body weight reaching statistical significance at 1.0 mg/kg. The maximum emetic dose of lycorine (ED(100)) was 2 mg/kg body weight. There was a correlation between dose and nausea score as well as between dose and number of the induced emetic events. Nausea and emesis were short-lasting and occurred not later than 2.5 h post dose. Lycorine showed linear plasma kinetics with a mean elimination half-life of 0.67 and 0.3 h after single s.c. and i.v. administration, compatible with the clinical course of nausea and emesis. The mean oral bioavailability was calculated to be about 40%. Biochemical and haematological parameters of safety showed no pathological signs. The results provide evidence that lycorine can be considered as a main, if not the crucial constituent responsible for nausea and emesis in human and animals in poisoning due to ingestion of plant material of the Amaryllidaceae. Copyright © 2010 Elsevier Ltd. All rights reserved.

  1. Carcinogenesis and Inflammatory Effects of Plutonium-Nitrate Retention in an Exposed Nuclear Worker and Beagle Dogs.

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, Christopher E. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Wang, Xihai [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Robinson, Robert J. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Brooks, Antone L. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Lovaglio, Jamie A. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Patton, Kristin M. [Battelle Toxicology Northwest, Richland, WA (United States); McComish, Stacey [United States Transuranium and Uranium Registries, Washington State University, College of Pharmacy, Richland, WA (United States); Tolmachev, Sergei Y. [United States Transuranium and Uranium Registries, Washington State University, College of Pharmacy, Richland, WA (United States); Morgan, William F. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)


    The genetic and inflammatory response pathways elicited following plutonium exposure in archival lung tissue of an occupationally exposed human and experimentally exposed beagle dogs were investigated. These pathways include: tissue injury, apoptosis and gene expression modifications related to carcinogenesis and inflammation. In order to determine which pathways are involved, multiple lung samples from a plutonium exposed worker (Case 0269), a human control (Case 0385), and plutonium exposed beagle dogs were examined using histological staining and immunohistochemistry. Examinations were performed to identify target tissues at risk of radiation-induced fibrosis, inflammation, and carcinogenesis. Case 0269 showed interstitial fibrosis in peripheral and subpleural regions of the lung, but no pulmonary tumors. In contrast, the dogs with similar and higher doses showed pulmonary tumors primarily in brochiolo-alveolar, peripheral and subpleural alveolar regions. The TUNEL assay showed slight elevation of apoptosis in tracheal mucosa, tumor cells, and nuclear debris was present in the inflammatory regions of alveoli and lymph nodes of both the human and the dogs. The expression of apoptosis and a number of chemokine/cytokine genes was slightly but not significantly elevated in protein or gene levels compared to that of the control samples. In the beagles, mucous production was increased in the airway epithelial goblet cells and glands of trachea, and a number of chemokine/cytokine genes showed positive immunoreactivity. This analysis of archival tissue from an accidentally exposed worker and in a large animal model provides valuable information on the effects of long-term retention of plutonium in the respiratory tract and the histological evaluation study may impact mechanistic studies of radiation carcinogenesis.

  2. Elucidation of Arctigenin Pharmacokinetics and Tissue Distribution after Intravenous, Oral, Hypodermic and Sublingual Administration in Rats and Beagle Dogs: Integration of In Vitro and In Vivo Findings. (United States)

    Li, Jie; Li, Xin; Ren, Yu-Shan; Lv, Yuan-Yuan; Zhang, Jun-Sheng; Xu, Xiao-Li; Wang, Xian-Zhen; Yao, Jing-Chun; Zhang, Gui-Min; Liu, Zhong


    Although arctigenin (AG) has diverse bioactivities, such as anti-oxidant, anti-inflammatory, anti-cancer, immunoregulatory and neuroprotective activities, its pharmacokinetics have not been systematically evaluated. The purpose of this work was to identify the pharmacokinetic properties of AG via various experiments in vivo and in vitro. In this research, rats and beagle dogs were used to investigate the PK (pharmacokinetics, PK) profiles of AG with different drug-delivery manners, including intravenous (i.v), hypodermic injection (i.h), and sublingual (s.l) administration. The data shows that AG exhibited a strong absorption capacity in both rats and beagle dogs (absorption rate 100%), and a strong elimination ability (t1/2 beagle dog (25.9 ± 3.24%) > rat (15.7 ± 9%) > monkey (3.69 ± 0.12%). This systematic investigation of pharmacokinetic profiles of arctigenin (AG) in vivo and in vitro is worthy of further exploration.

  3. Dog-appeasing pheromone collars reduce sound-induced fear and anxiety in beagle dogs: a placebo-controlled study


    Landsberg, G. M.; Beck, A.; Lopez, A; Deniaud, M.; ARAUJO, J.A.; Milgram, N. W.


    The objective of the study was to assess the effects of a dog-appeasing pheromone (DAP) collar in reducing sound-induced fear and anxiety in a laboratory model of thunderstorm simulation. Twenty-four beagle dogs naïve to the current test were divided into two treatment groups (DAP and placebo) balanced on their fear score in response to a thunderstorm recording. Each group was then exposed to two additional thunderstorm simulation tests on consecutive days. Dogs were video-assessed by a train...

  4. Polarization microscopy of picrosirius red-stained collagen from oxodipine-induced hyperplastic gingiva of beagle dogs. (United States)

    Dayan, D; Waner, T; Tal, H; Nyska, A


    Using the model of oxodipine-induced gingival hyperplasia in beagle dogs, we investigated the collagen fibres of the hyperplastic gingiva by measuring the polarization colours from Picrosirius-red stained sections. The predominant polarization colours of the thick collagen fibres (1.6-2.4 microns diameter) of male oxodipine-treated dogs were greenish-yellow to yellow, while in controls and in female oxodipine-treated dogs, the same size fibres mostly appeared orange and red. These differences may be indicative of gender variation in the genesis of hyperplastic gingiva in calcium channel blocker treated dogs.

  5. Dynamics of Alloplastic Bone Grafts on an Early Stage of Corticotomy-Facilitated Orthodontic Tooth Movement in Beagle Dogs (United States)

    Choi, Hyung-Joo; Kim, Tae-Woo


    Alveolar augmented corticotomy is effective in accelerating orthodontic tooth movement, but the effect only lasts for a relatively short time. Therefore, the purpose of this study was to investigate the underlying biology of the immediate periodontal response to orthodontic tooth movement after a corticotomy with alloplastic bone grafts. The results demonstrated that measurable tooth movement began as early as 3 days after the intervention in beagle dogs. Based on the results and histological findings, augmented corticotomy-facilitated orthodontic tooth movement might enhance the condition of the periodontal tissue and the stability of the outcomes of orthodontic treatment. PMID:25276787

  6. Dynamics of Alloplastic Bone Grafts on an Early Stage of Corticotomy-Facilitated Orthodontic Tooth Movement in Beagle Dogs

    Directory of Open Access Journals (Sweden)

    Hyung-Joo Choi


    Full Text Available Alveolar augmented corticotomy is effective in accelerating orthodontic tooth movement, but the effect only lasts for a relatively short time. Therefore, the purpose of this study was to investigate the underlying biology of the immediate periodontal response to orthodontic tooth movement after a corticotomy with alloplastic bone grafts. The results demonstrated that measurable tooth movement began as early as 3 days after the intervention in beagle dogs. Based on the results and histological findings, augmented corticotomy-facilitated orthodontic tooth movement might enhance the condition of the periodontal tissue and the stability of the outcomes of orthodontic treatment.

  7. Environmental pollution and shipping feasibility of the Nicaragua Canal. (United States)

    Chen, Jihong; Zeng, Xin; Deng, Yibing


    In recent years, the Nicaraguan government's renewed interest in constructing this interoceanic canal has once again aroused widespread concern, particularly in the global shipping industry. The project's immense ecological risks, coupled with the recent expansions of both the Panama Canal and the Suez Canal, have raised questions among scientists and experts about its viability. Whether the Nicaragua Canal is really feasible for international shipping, given its high marine pollution risks, requires the further study. This paper discusses and analyses the feasibility of the Nicaragua Canal in the context of its environmental impact and value as a shipping service. This paper aims to provide an important information reference to inform strategic decision-making among policymakers and stakeholders. Our research results indicate that the environmental complexity, economic costs and safety risks of building a new transoceanic canal are simply too high to justify the project. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Root canal filling evaluation using optical coherence tomography (United States)

    Negrutiu, Meda L.; Sinescu, Cosmin; Hughes, Michael; Bradu, Adrian; Todea, Carmen; Balabuc, Cosmin I.; Filip, Laura M.; Podoleanu, Adrian Gh.


    The root canal fillings are destined to seal the root canal especially in the apical areea. Invasive techniques are known which are used to assess the quality of the seal. These lead to the destruction of the probes and often no conclusion could be drawn in respect to the existence of any microleakage in the investigated areas of interest. Optical coherence tomography (OCT) is a relatively novel non-invasive imaging technique which presents potential in assessing the microleakage of the apical area in the root canal fillings with micron depth resolution. 3D reconstruction allows a complete view with obvious display of gaps in the apical root canal filling. For this study, 30 monoradicular teeth were prepared by conventional and rotative methods. Afterwards, root canal fillings were produced in each tooth. The images obtained show some microleakage in all the investigated root canal fillings. The advantages of the OCT method consist in non-invasiveness and high resolution.

  9. Canal of Nuck hernia: a multimodality imaging review

    Energy Technology Data Exchange (ETDEWEB)

    Rees, Mitchell A. [University of Pittsburgh Medical Center, Department of Radiology, Pittsburgh, PA (United States); Squires, James E. [Children' s Hospital of Pittsburgh of UPMC, Department of Gastroenterology, Pittsburgh, PA (United States); Tadros, Sameh; Squires, Judy H. [University of Pittsburgh Medical Center, Department of Radiology, Pittsburgh, PA (United States); Children' s Hospital of Pittsburgh of UPMC, Department of Radiology, Pittsburgh, PA (United States)


    Canal of Nuck abnormalities are a rare but important cause of morbidity in girls, most often those younger than 5 years of age. The canal of Nuck, which is the female equivalent of the male processus vaginalis, is a protrusion of parietal peritoneum that extends through the inguinal canal and terminates in the labia majora. The canal typically obliterates early in life, but in some cases the canal can partially or completely fail to close, potentially resulting in a hydrocele or hernia of pelvic contents. Recognition of this entity is especially important in cases of ovarian hernia due to the risk of incarceration and torsion. We aim to increase awareness of this condition by reviewing the embryology, anatomy and diagnosis of canal of Nuck disorders with imaging findings on US, CT and MRI using several cases from a single institution. (orig.)

  10. El escritor, las sombras y la Patria: En esta dulce tierra de Andrés Rivera The writer, the shadows and the homeland in Andrés Rivera's "La dulce tierra"

    Directory of Open Access Journals (Sweden)

    Carmen Perilli


    Full Text Available La novela En esta dulce tierra arma un simulacro histórico que se desintegra en una narración de finales múltiples. Parodia su nombre "en esta dulce tierra" ya que el circunstancial anuncia sucesos terribles que hacen estallar el adjetivo. Remite a la literatura decimonónica, en especial a los romances fundacionales como Amalia de José Mármol. La nación se imagina como espacio cerrado, clausurado por el despotismo en el asilo, la morgue, la cárcel, el sótano. Los protagonistas se mueven ilusoriamente de Sur a Norte. Si Sarmiento invoca la sombra de Facundo, Rivera evoca en Cufré otras propias sombras, dobles en tiempos y lugares otros. La narración de la historia argentina es la narración de una derrota, la de la civilización. La imagen histórica es disfórica: el mundo está enfermo, ebrio de sangre y violencia. Facundo es la sombra de la barbarie, cifra de la naturaleza americana, producto de los llanos riojanos. Cufré es la sombra de una clase "culta" que dibuja en su trayectoria una figura paradojal. Las dos son víctimas de una tierra concebida como naturaleza bárbara en un caso y de una tierra construida como patria siniestra en el otro. El Poder actúa como una segunda naturaleza que, en esta tierra, tiene el sabor de la muerte.The novel En esta dulce tierra sets up a historical pretense that disintegrates into several endings. The title is an irony, since terrible events take place in this "sweet land." It refers to the literature of the XIX century, especially to the founding romances such as that of José Mármol's Amalia. The nation is envisioned as a closed space relegated by despotism to the asylum, the morgue, the jail, the basement. The characters live an illusion moving from north to south. If Sarmiento invokes the shadow of Facundo, Rivera evokes some of his own shadows in Cufré, doubles in different times and spaces. The narration of the Argentine history is a story of defeat: civilizarion's. The historical

  11. EL SITIO HESHKAIA 35: NUEVOS DATOS SOBRE LA ARQUEOLOGÍA DE MOAT (TIERRA DEL FUEGO, ARGENTINA / Heshkaia 35 site: new data on the archaeology of Moat (Tierra del Fuego, Argentina

    Directory of Open Access Journals (Sweden)

    Atilio Francisco Zangrando


    Full Text Available arqueológicos recuperados en el sitio Heshkaia 35 (costa sur de Tierra del Fuego, Argentina. Este sitio se ubica en un ámbito costero en la sección media de la cuenca del río Moat y registra ocupaciones durante el Holoceno Tardío (ca. 800-500 AP. La diversidad tecnológica y el registro zooarqueológico señalan el desarrollo de actividades múltiples. Los artefactos líticos dominan el conjunto tecnológico. Los desechos líticos indican un fuerte énfasis hacia los estadios finales de talla, puesto de manifiesto en la baja presencia de artefactos con corteza y la elevada frecuencia de lascas de formatización y de reactivación de filos. El conjunto zooarqueológico se compone mayormente de restos óseos de guanacos. Los moluscos también habrían cumplido un rol significativo en la dieta. Restos óseos de mamíferos marinos, zorros, aves y peces están representados por frecuencias bajas. La composición artefactual y arqueofaunística estaría indicando que el aprovisionamiento de recursos se habría articulado principalmente desde el ámbito costero y no necesariamente en el mar. Se discuten las implicaciones de esta evidencia para las pautas conductuales de cazadores-recolectores en la costa sur de Tierra del Fuego. Palabras Clave: Arqueología de costas, Cazadores-recolectores, Tierra del Fuego, Holoceno Tardío   Abstract This paper presents and discusses the archaeological evidence from Heshkaia 35 site (southern coast of Tierra del Fuego, Argentina. This site is located in a coastal setting in the middle section of the Moat River Basin and records occupations during the Late Holocene (ca. 800-500 BP. Technological diversity and the zooarchaeological record point to the development of multiple activities. Lithic artifacts dominate the technological assemblage. Lithic debitage indicates a strong emphasis towards final stages of reduction, shown by the lower occurrence of artifacts with cortex and the high frequency resharpening

  12. Single visit root canal treatment: A prospective study

    African Journals Online (AJOL)


    Aug 31, 2013 ... Post‑operative pain in multiple‑visit and single‑visit root canal treatment. J Endod 2010;36:36‑9. 13. Ferranti P. Treatment of the root canal of an infected tooth in one appointment: A report of 340 cases. Dent Dig 1959;65:49‑53. 14. Ufomata D. One‑visit root canal therapy: A preliminary clinical study in ...

  13. Three root canals in the maxillary second premolar

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    de Almeida-Gomes Fabio


    Full Text Available In this study, we report an endodontic treatment of the maxillary second premolar with three root canals and distinct foramens. The possibility of three root canals in this tooth is quite small; however, it must be taken into account in clinical and radiographic evaluation during endodontic treatment. Many times, their presence is noticed only after canal treatment due to continuing post-operative discomfort.

  14. Micro-Machined Flow Sensors Mimicking Lateral Line Canal Neuromasts


    Hendrik Herzog; Siegfried Steltenkamp; Adrian Klein; Simon Tätzner; Elisabeth Schulze; Horst Bleckmann


    Fish sense water motions with their lateral line. The lateral line is a sensory system that contains up to several thousand mechanoreceptors, called neuromasts. Neuromasts occur freestanding on the skin and in subepidermal canals. We developed arrays of flow sensors based on lateral line canal neuromasts using a biomimetic approach. Each flow sensor was equipped with a PDMS (polydimethylsiloxane) lamella integrated into a canal system by means of thick- and thin-film technology. Our artificia...

  15. [Canal infection. Ecological theory and repair with osteodentin]. (United States)

    Muñiz, M A; Zeberio, T


    The characteristics of the infection in the root canal are analyzed, specially its development before pulpal necrosis. It is inferred that it is an ecological infection with a function: to decompose the necrosis. Inactivating the infection in the canal by the formocresol technique, calcium hidroxide or with the conventional basic treatment in Endodontics, cleaning, washing, disinfecting and, in this case, with partial obturation of the canal, it is possible to induce a reparation with osteodentine that can cover all the free extension of the canal.

  16. Políticas publicas y pueblos indígenas: El caso de las tierras mapuche en neuquen (Argentina) y la araucania (Chile) -estudios de casos "conflicto público de tierras y recursos naturales"


    SEGUEL, A.


    Metadata only record El análisis a las políticas públicas de tierras, no se puede limitar exclusivamente a las acciones u omisiones dentro de su legislatura "indígenista" que desarrollan órganos de los Estados hacia los Mapuche y sus comunidades. Dentro del ámbito de la política pública de los Estados existen una serie de elementos internos y externos que están ligados a diversos aspectos de la globalización económica, cuyos impactos repercuten principalmente en los territorios de sectores...

  17. Estabilidad antisísmica de taludes en presas de tierra

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    Giuliani, H.


    Full Text Available At present, economic reasons and the high development of technological knowledge lead to the construction of structures with low factors of safety. This makes it necessary to have accurate knowledge of the real bebaviour of the materials. This problem is of special importance when the seismic factor intervenes. In recent years it has become common practice to analyse the stability of soil embankments located in seismic zones, using the seismic factor in conjunction with the surface sliding method. Taking into account that existing methods of analysis lead to varying factors of safety, and that safety factor one is the lowest acceptable when there is a seismic effect, it will be obvious that more accurate methods are now essential. This paper includes: a A description of the most recent methods at present in use. Special attention has been given to more accurate methods, which take account of intergranular forces action on the lateral faces of the various wedges into which the sliding mass is divided. b An analytical solution suggested by the author. c Solutions involving the seismic effect, applicable to all above mentioned methods. d Brief comments on the various methods. e Numerical application to a typical embankment.En la actualidad, los factores económicos y el gran desarrollo de la técnica conduce a la realización de estructuras con escasos coeficientes de seguridad, lo cual exige tener muy en cuenta el comportamiento real de las mismas. Este problema reviste particular importancia cuando interviene el efecto sísmico. En los últimos años se ha hecho práctica común analizar la estabilidad de taludes de presa de tierra, en zonas sísmicas, por el método del «coeficiente sísmico en combinación con el método de la superficie de deslizamiento». Teniendo en cuenta el hecho de que los métodos existentes a esta categoría general dan coeficientes de seguridad diferentes y que el coeficiente 1 es el mínimo aceptable cuando existe

  18. La ganadería lanar en Madrid y su tierra durante la Edad Media

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    Tomás Puñal Fernández


    Full Text Available El estudio de la ganadería en general y ovina en particular ofrece un campo muy generoso de investigación porque permite conocer muchas de las estructuras socioeconómicas regionales y locales de un país o territorio. En el caso de Madrid dicho estudio es importante por cuanto en el conjunto de las labores agropecuarias del concejo, las ganaderas fueron las que mejor marcaron su desarrollo económico. La tierra madrileña es tierra de ganado, sobre todo lanar, y ello fue el punto de referencia de diversas actividades económicas que iban desde el abastecimiento de carne para la alimentación hasta la obtención de materia prima, lana y pieles, para las industrias textil y del cuero. Para tener una visión más amplia e interdisciplinar el presente estudio se ha hecho desde una doble perspectiva económica y social. Desde la ganadería estante y local a la trashumante, con especial mención a la Mesta y toda su problemática, así como los aspectos cuantitativos derivados del número de ovejas y el tamaño y tipo de los rebaños y sus aspectos fiscales concomitantes. En relación a ello toda la infraestructura de pastos y cañadas. Los aspectos sociales se refieren a los propietarios de ovejas como una oligarquía rural de labradores enriquecidos, así como a los trabajadores del ganado, es decir los pastores, sus contratos, salarios y condiciones de vida. En conjunto el panorama que se ofrece es muy significativo y permite acercarnos un poco más a la realidad socioeconómica del Madrid medieval.The study of the livestock in general and sheep in particular, offers a huge field to research as it allows to know many of the local and regional socioeconomíc structures of a city or country. In the case of Madrid, that study is important because the sheep livestock is, among the rest of the agricultural activities, the main one for its contribution to the economic development. Madrid is a livestock área, mainly for sheep, as the point of

  19. Mandibular second premolar with three canals: Re-treatment of a case with unusual root canal anatomy

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    Niranjan Desai


    Full Text Available A thorough knowledge of root canal anatomy along with the anatomical variations that may be present is essential for success of endodontic therapy. Unusual presentations in the number of the roots or the canals should be expected in every tooth. Mandibular second premolars are thought of as having a single root and canal. Studies have stated that the prevalence of three canals with three orifices in this tooth is 0.4%. The mandibular second premolar is particularly difficult to treat owing to the fact that a wide variation in the number, location and curvature of the roots and canals exist. Added to this is the fact that the access opening is restricted and location of the lingually placed orifices is difficult. This case report details the re-treatment of a mandibular second premolar with three canals and three separate orifices using the surgical microscope.

  20. Mires and mire types of Peninsula Mitre, Tierra del Fuego, Argentina

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    A. Grootjans


    Full Text Available In 2007, a field visit by members of the International Mire Conservation Group (IMCG to the Atlantic coast of Peninsula Mitre (the easternmost part of Isla Grande de Tierra del Fuego, Argentina gathered information on mire diversity in this remote wild area with largely pristine mires. Our expedition showed that Peninsula Mitre hosts a wide variety of habitats across two exciting ecological gradients: (i a regional west–east gradient from Sphagnum magellanicum dominated mires in the west to Astelia pumila dominated mires in the east; and (ii a gradient from extremely acid to extremely carbonate rich mire types induced by local bedrock. The large variety of hydromorphological mire types comprises raised bogs, blanket bogs, sloping fens, string fens, flat fens and calcareous spring fens. In the Atlantic coastal area, the abundance of Sphagnum magellanicum in the ombrogenic systems decreases conspicuously from west to east with the species being almost absent in the east. However, the fossil record shows thick layers of Sphagnum peat close beneath mire surfaces everywhere, indicating that substantial hydrological and ecological changes have taken place in the recent past. We observed large scale erosion in the mires along the Atlantic coast. Locally, well-developed fen systems are present, including calcareous spring fens with active travertine (tufa deposition. The regional vegetation can be regarded as a parallel to that of boreal oceanic regions in the northern hemisphere. The mires and peatlands of the peninsula are of global significance. They are impressive, peculiar, extensive and largely pristine mires in a globally very rare climatic and biogeographical context embedded in a landscape with significant natural dynamics. The damaging impact of free-roaming cattle on the mires and upland vegetation is, however, conspicuous and needs urgent attention. Peninsula Mitre deserves the highest possible protection, e.g. as a provincial protected


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    Fabián Almonacid Z


    Full Text Available Se estudia el conflicto en torno a la propiedad de la tierra en el sur de Chile (principalmente en la Araucanía, Valdivia y Osorno, el que tuvo como protagonistas al Estado, chilenos y extranjeros. Se revisan los antecedentes del problema, especialmente la llegada de población chilena y extranjera a la zona y la presencia de comunidades indígenas, entre mediados del siglo XIX y 1929. Después, la búsqueda de una solución, a través de diversas leyes, la acción de un ministerio especial y, particularmente, la política estatal sobre comunidades indígenas. En general, se destaca el interés estatal por consolidar la propiedad rural privada, mediante el reconocimiento rápido de los propietarios con títulos y de los ocupantes efectivos y el término de las comunidades indígenas. El éxito de la labor estatal fue parcial, fortaleciendo la propiedad privada, pero sin lograr acabar con la propiedad comunitaria.This paper analyzes conflicts over land ownership in Southern Chile (Araucanía, Valdivia and Osorno mainly. This conflict had as its main protagonists the State, Chileans and foreigners. After the revision of its background, including the arrival of Chileans and foreigners to the area and the presence of indigenous communities, the article pays attention to the efforts made trough legislation, ministerial work and State policies over indigenous communities to solve the problem. This reveals the attempt made by the State to consolidate rural private ownership. This was made trough expedite recognition of owners in possession of land titles and land settlers, in an effort to put an end to indigenous communities. The success was partial because communal land ownership did not disappear, despite the strengthening of private land ownership.

  2. The Patagonian Orocline: New paleomagnetic data from the Andean magmatic arc in Tierra del Fuego, Chile (United States)

    Cunningham, W. Dickson; Klepeis, Keith A.; Gose, Wulf A.; Dalziel, Ian W. D.


    The Hardy Formation is a 1300-m-thick succession of Upper Jurassic-Lower Cretaceous volcaniclastic sedimentary rocks interbedded with lava flows on Hoste Island at the southernmost tip of South America (55.5°S, 291.8°E). The strata are gently folded and metamorphosed to the prehnite-pumpellyite grade. A well-defined characteristic direction of magnetization, carried by magnetite, was readily identified in 95 samples from seven sites. At a given site, the directions group slightly better without structural correction. However, the means of the seven sites cluster better without tilt correction at the 99% significance level, implying that the magnetization postdates the folding event. It is most likely that the magnetization was acquired during the mid- to Late Cretaceous Andean orogeny that involved the folding and emplacement of the Patagonian Batholith. The fact that all samples are normally magnetized supports this age assignment. The pole position of 42.9°N, 156.6°E, α95=3.3° implies that the sampling area has rotated counterclockwise relative to cratonic South America by 90.1±11.9° with no significant flattening of inclination (F=1.9 ± 3.7°). Geologic considerations indicate that the rotation involved the entire Andean magmatic arc in Tierra Del Fuego. The results support interpretation of the Hardy Formation as part of the Andean magmatic arc deposited on the Pacific side of the Late Jurassic-Early Cretaceous Rocas Verdes marginal basin. Oroclinal bending of the arc in southernmost South America accompanied inversion of the marginal basin and the development of a Late Cretaceous-Cenozoic left-lateral transform system (South America-Antarctica) that later developed into the North Scotia Ridge.

  3. A Novel HA/β-TCP-Collagen Composite Enhanced New Bone Formation for Dental Extraction Socket Preservation in Beagle Dogs

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    Ko-Ning Ho


    Full Text Available Past studies in humans have demonstrated horizontal and vertical bone loss after six months following tooth extraction. Many biomaterials have been developed to preserve bone volume after tooth extraction. Type I collagen serves as an excellent delivery system for growth factors and promotes angiogenesis. Calcium phosphate ceramics have also been investigated because their mineral chemistry resembles human bone. The aim of this study was to compare the performance of a novel bioresorbable purified fibrillar collagen and hydroxyapatite/β-tricalcium phosphate (HA/β-TCP ceramic composite versus collagen alone and a bovine xenograft-collagen composite in beagles. Collagen plugs, bovine graft-collagen composite and HA/β-TCP-collagen composite were implanted into the left and right first, second and third mandibular premolars, and the fourth molar was left empty for natural healing. In total, 20 male beagle dogs were used, and quantitative and histological analyses of the extraction ridge was done. The smallest width reduction was 19.09% ± 8.81% with the HA/β-TCP-collagen composite at Week 8, accompanied by new bone formation at Weeks 4 and 8. The HA/β-TCP-collagen composite performed well, as a new osteoconductive and biomimetic composite biomaterial, for socket bone preservation after tooth extraction.

  4. Contact heat thermal threshold testing in beagle dogs: baseline reproducibility and the effect of acepromazine, levomethadone and fenpipramide

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    Hoffmann Marina Verena


    Full Text Available Abstract Background In this methodology article a thermal threshold testing device designed to test nociception in cats was assessed in six dogs. The purpose of this study was to investigate baseline reproducibility of thermal thresholds obtained by the contact heat testing device, to assess the influence of acepromazine and levomethadone and fenpipramide in dogs. The relationship between change in nociceptive thermal threshold and the opioid′s plasma concentration was determined. Six adult beagle dogs received levomethadone (0.2 mg/kg, acepromazine (0.02 mg/kg or saline placebo by intramuscular injection (IM in a randomized cross-over design. Three baseline nociceptive thermal threshold readings were taken at 15 minutes intervals prior to treatment. Further readings were made at 15, 30, 45, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330, 360, 420 and 480 minutes after injection. A sedation score was assigned at every reading. Four saline placebo treatments were performed to assess baseline reproducibility. Levomethadone serum concentrations were measured prior and 0.5, 1, 2, 4, 8, 12 and 24 hours after drug dosing in a separate occasion. Results Acepromazine did not seem to increase the thermal threshold at any time. After levomethadone there was a significant rise of the thermal threshold between 15 to 120 minutes at serum concentrations between 22.6-46.3 ng/mL. Baseline reproducibility was stable in adult beagle dogs. Conclusion The thermal threshold testing system is a suitable device for nociceptive threshold testing in dogs.

  5. Multistage cancer models of bone cancer induction in beagles and mice by radium and plutonium, compared to humans

    Energy Technology Data Exchange (ETDEWEB)

    Bijwaard, H.; Brugmans, M. [RIVM-National Inst. for Public Health and the Environment, Lab. for Radiation Research, MA Bilthoven (Netherlands)


    Two-mutation carcinogenesis models of mice injected with Pu-239 and Ra-226 have been derived as an extension of previous modellings of beagle dogs injected with Pu-239 and Ra-226 and dial painters that ingested radium. In all cases the data could be fitted adequately using no more than five free model parameters. Apart from three parameters for the background, these include two dose-related parameters: a linear mutation coefficient that is equal in both mutational steps and a usually non-zero cell-killing coefficient in the second mutational step. After a simple scaling the animal models compare reasonably well with each other and with the model for the radium dial painters. From the toxicity ratio of beagle models for Pu-239 and Ra-226, together with the human model for Ra-226, an approximate model for the exposure of humans to Pu-239 has been constructed. Relative risk calculations with this approximate model are in good agreement with epidemiological findings for the plutonium-exposed Mayak workers. This promising result may indicate new possibilities for estimating risks for humans from animal experiments. (orig.)

  6. Effect of food intake on the pharmacokinetics of sarpogrelate and its active metabolite following oral administration to beagle dogs. (United States)

    Baek, In-Hwan; Lee, Byung-Yo; Kim, Min-Soo; Kwon, Kwang-Il


    1. The objectives of this study were to develop a pharmacokinetic model for sarpogrelate and its metabolite M-1 and to identify the effect of food on sarpogrelate and M-1 pharmacokinetics in beagle dogs. 2. A single 100 mg oral dose of sarpogrelate was administered to fasted and fed beagle dogs and the plasma concentrations of sarpogrelate and M-1 were measured simultaneously by liquid chromatography tandem mass spectrometry. The resultant data were analyzed by modeling approaches using ADAPT5. 3. The plasma concentration time course of sarpogrelate and M-1 were described using a parent-metabolite compartment model with first-order absorption and elimination. The systemic exposure of sarpogrelate and its metabolite after the administration of a single 100 mg oral dose was significantly decreased under the fed condition compared to that under the fasting condition. Modeling approaches have sufficiently explained the food effect of sarpogrelate, i.e. an increased Vc and decreased Ka, in fed dogs. The food effect of sarpogrelate was due to its pH-dependent dissolution. 4. These findings suggest that food intake affects both the rate and extent of absorption of sarpogrelate, and that the pharmacological effect of sarpogrelate can differ significantly according to food intake.

  7. Integrated TK-TD modeling for drug-induced concurrent tachycardia and QT changes in beagle dogs. (United States)

    Wu, Fan; Heimbach, Tycho; Hatsis, Panos; Tang, Hai-Ming; Dugyala, Raviprakash; Yue, Qin; Wang, Tao; He, Handan


    Drug-induced cardiotoxicity, including tachycardia and QT prolongation, remains a major safety concern that needs to be identified and its risk mitigated in early stages of drug development. In the present study, an integrated toxicokinetic-toxicodynamic (TK-TD) modeling approach within a nonlinear mixed-effect modeling framework is applied to investigate concurrent abnormal heart rate and QT changes in three beagle dogs, using a Novartis internal compound (NVS001) as the case example. By accounting for saturable drug absorption, circadian rhythms, drug-effect tolerance, and nonlinear rate-dependency of QT interval, the dynamic TK-TD model captures the experimentally observed drug effects on heart rate and QT interval across a wide dosing range of NVS001 in beagle dogs. Further analyses reveal that the NVS001-induced QT prolongation observed in the low-dose groups is potentially caused by direct drug inhibition on the hERG channel, while the apparent QT shortening in the high-dose groups may be due to strong rate-dependency of QT at high heart rates. This study also suggests that the TK-TD model can be used to identify direct drug effects on the non-rate-dependent QT component by dissociating QT changes from tachycardia and deriving a new QT correction method. The integrated TK-TD model presented here may serve as a novel quantitative framework for evaluating drug-induced concurrent changes in heart rate and QT to potentially facilitate preclinical and clinical safety studies.

  8. Biological effects of inhaled {sup 144}CeCl{sub 3} in beagle dogs

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, F.F.; Boecker, B.B.; Griffith, W.C.; Muggenburg, B.A. [Inhalation Toxicology Research Institute, Albuquerque, NM (United States)


    The biological effects of {sup 144}Ce were studied in beagle dogs that were exposed to graded activity levels of {sup 144}CeCl{sub 3} via a single, brief inhalation exposure and observed for their life span. The long-term retained body burdens ranged from 0.06 to 13 MBq/kg with a median of 1.2 MBq/kg. After a short residence time in the lung, most of the {sup 144}Ce was translocated to liver and skeleton, where the {sup 144}Ce was retained with a half-time approaching the physical half-life of {sup 144}Ce was retained with a half-time approaching the physical half-life of {sup 144}Ce, 284 days. Significant radiation doses were delivered to the lung, 28 Gy (median) and 2.5-370 Gy (range); liver, 68 Gy (median) and 6.1-250 Gy (range); and skeleton, 21 Gy (median) and 1.9-100 Gy (range). Lesions induced by the {beta}-particle radiation were noted in the lung, liver, skeleton, bone marrow, and oral and nasal mucosae closely associated with bond. Early deaths (within 2.5 years) were generally related to hematological dyscrasia, radiation pneumonitis, or hepatocellular degeneration and atrophy. Neoplasms that occurred relatively early, from 2.2-6.8 years after exposure, were noted in the liver, bone, bone marrow and oral mucosa closely associated with bone. Neoplasms that occurred later, beyond 7 years after exposure, were noted in the liver, lung and nasal mucosa closely associated with bone. Increased numbers of neoplasms were not found in two other organs that had relatively high radiation doses, namely the thyroid and kidney. Only one primary bone tumor was noted, but 11 tumors of bone-associated tissues (oral and nasal mucosae and bone marrow) were found. Radiation doses and effects in tissues adjacent to bone, especially those of epithelial or marrow origin, should be considered when determining risks from internally deposited bone-seeking radionuclides, such as {sup 144}Ce. 59 refs., 8 figs., 10 tabs.

  9. Characterisation of tramadol, morphine and tapentadol in an acute pain model in Beagle dogs. (United States)

    Kögel, Babette; Terlinden, Rolf; Schneider, Johannes


    To evaluate the analgesic potential of the centrally acting analgesics tramadol, morphine and the novel analgesic tapentadol in a pre-clinical research model of acute nociceptive pain, the tail-flick model in dogs. Prospective part-randomized pre-clinical research trial. Fifteen male Beagle dogs (HsdCpb:DOBE), aged 12-15 months. On different occasions separated by at least 1 week, dogs received intravenous (IV) administrations of tramadol (6.81, 10.0 mg kg(-1) ), tapentadol (2.15, 4.64, 6.81 mg kg(-1) ) or morphine (0.464, 0.681, 1.0 mg kg(-1) ) with subsequent measurement of tail withdrawal latencies from a thermal stimulus (for each treatment n = 5). Blood samples were collected immediately after the pharmacodynamic measurements of tramadol to determine pharmacokinetics and the active metabolite O-demethyltramadol (M1). Tapentadol and morphine induced dose-dependent antinociception with ED50-values of 4.3 mg kg(-1) and 0.71 mg kg(-1) , respectively. In contrast, tramadol did not induce antinociception at any dose tested. Measurements of the serum levels of tramadol and the M1 metabolite revealed only marginal amounts of the M1 metabolite, which explains the absence of the antinociceptive effect of tramadol in this experimental pain model in dogs. Different breeds of dogs might not or only poorly respond to treatment with tramadol due to low metabolism of the drug. Tapentadol and morphine which act directly on μ-opioid receptors without the need for metabolic activation are demonstrated to induce potent antinociception in the experimental model used and should also provide a reliable pain management in the clinical situation. The non-opioid mechanisms of tramadol do not provide antinociception in this experimental setting. This contrasts to many clinical situations described in the literature, where tramadol appears to provide useful analgesia in dogs for post-operative pain relief and in more chronically pain states. © 2014 Association of Veterinary

  10. Cystacanths of Acanthocephala in notothenioid fish from the Beagle Channel (sub-Antarctica). (United States)

    Laskowski, Zdzisław; Jezewski, Witold; Zdzitowiecki, Krzysztof


    The morphology of relaxed cystacanths of polymorphid acanthocephalans collected from notothenioid fishes in the Beagle Channel (Magellanic subregion of sub-Antarctica) is described. A parasite of birds, Andracantha baylisi (Zdzitowiecki, 1986), was found in Patagonotothen longipes and Champsocephalus esox. It has: a proboscis 0.82-0.89 mm long; a proboscis hook formula of 16 rows of 9/10-10/11, including 4-5 basal hooks; distal hooks with the longest blades; a fore-trunk not separated from the hind-trunk by a constriction; large somatic spines arranged in two zones separated by a zone of small, loosely dispersed spines; and only the anterior 36-40% of ventral side of the trunk is covered with spines. One male specimen of Corynosoma sp. was found in Patagonotothen tessellata. It differs from A. baylisi in that the distal proboscis hooks are similar in length to the prebasal hooks, it has a smaller proboscis (0.77 mm) and in the distribution of the somatic spines, which are contiguous with the genital spines on the ventral side of the trunk and lack a zone of small spines between zones of larger spines. A parasite of seals and fur seals, Corynosoma evae Zdzitowiecki, 1984, was found in P. longipes and Champsocephalus esox. It has: a proboscis 0.61-0.78 mm long; a proboscis hook formula of 20-22 rows of 12-13, including 3/4-4 basal hooks; prebasal hooks with the longest blades; a trunk divided into fore-trunk and hind-trunk; somatic spines covering the anterior 64-74% of the ventral side of the trunk; genital spines present only in males; and a terminal genital opening in both sexes. Corynosoma beaglense n. sp. was found in Champsocephalus esox. It has: an almost cylindrical proboscis (length 0.52-0.56 mm); a proboscis hook formula of 16 rows of 9/10-10/11, including 4-4/5 basal hooks; distal hooks shorter than the prebasal hooks; a fore-trunk not separated from the hind-trunk by a constriction; somatic spines contiguous with the genital spines on the ventral side of

  11. [Urodynamic study of obstruction induced by vesicoureteral reflux surgery with submucosal advance in beagle female dogs]. (United States)

    Guillonneau, B; Wetzel, O; Buzelin, J M


    The treatment of veslcoureteric reflux by submucosal advancement is effective in human clinical practice on nondilated refluxing ureters, with a low morbidity. In contrast, the results of this technique in the presence of concomitant disease such as megaureter appear to be less favourable and could be due to obstruction induced by the reflux surgery. The objective of this study was to evaluate the urodynamic modifications of ureterovesical reimplantation in 10 female Beagle dogs. Left ureterovesical reimplantation by submucosal ureteric advancement was performed in each animal which constituted its own control. The morphological results were assessed by intravenous urography and retrograde cystography. The urodynamic study was conducted during another surgical operation performed, on average, around the 18th postoperative week. A 6F two-channel probe was inserted on each ureter: while a pump delivered a constant infusion (2 then 5 ml/min) into one channel, the ureteric pressure was measured by the other channel. The bladder pressure was recorded by a bladder catheter. For each infusion rate, the increased pressure in the reimplanted ureter was compared to that measured in the control ureter, as a function of the bladder pressure. The subsequent morphological evaluation demonstrated the absence of any repercussions on the upper urinary tract and the absence of vesicoureteric reflux and paraureteric diverticulum. An initial increase in the basal ureteric pressure was observed at the beginning of the infusion and was significantly higher in the operated ureter than in the control ureter (for an infusion rate of 2 then 5 ml/min, p = 0.0008 and 0.00029, respectively). The mean ureteric pressures increased in parallel, but those recorded in the reimplanted ureter were significantly higher than those recorded in the control ureter (p < 0.01). Ureteric pressure peaks were only recorded on the reimplanted left ureter at an infusion rate of 2 ml/min. These results suggest

  12. Passive ureteral dilation and ureteroscopy after ureteral stent placement in five healthy Beagles. (United States)

    Vachon, Catherine; Defarges, Alice; Brisson, Brigitte; Nykamp, Stephanie; Weese, J Scott; Denstedt, John; Berent, Allyson C


    OBJECTIVE To determine whether passive ureteral dilation (PUD) would occur after an indwelling ureteral stent was left in place in healthy dogs for 2 or 6 weeks, ureteroscopy would be possible at the time of stent removal, and PUD would be reversible after stent removal. ANIMALS 5 healthy adult female Beagles. PROCEDURES A ureteral stent was cystoscopically placed in each ureter of each dog with fluoroscopic guidance (week 0). One stent was removed from 1 ureter in each dog after 2 weeks (ureter group 1), and the other was removed after 6 weeks (ureter group 2); removal timing was randomized. Computed tomographic excretory urography was performed every 2 weeks from weeks 0 through 10 to measure ureteral diameters. Ureteroscopy was attempted at the time of ureteral stent removal in each group. Ureteral diameters were compared among measurement points. RESULTS The degree of PUD was significant after 2 and 6 weeks of stent placement in both ureter groups. Mean diameter of the midportion of the ureter in both groups prior to stent placement was 1.70 mm (range, 1.3 to 2.7 mm). At stent removal, mean diameter of the midportion of the ureter was 2.86 mm (range, 2.4 to 3.1 mm) in group 1 and 2.80 mm (range, 2.1 to 3.4 mm) in group 2. Ureteroscopy was successfully performed in all dogs up to the renal pelvis. Compared with week 0 values for diameter of the midportion of the ureter, the degree of PUD induced by stent placement had reversed by week 8 in group 1 (mean diameter, 2.00 mm [range, 1.5 to 2.3 mm]). CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that ureteral stent placement for 2 weeks would result in sufficient PUD in healthy dogs to allow ureteroscopy at the time of stent removal and that the original ureteral diameter would eventually be restored. Additional research is needed to determine whether findings would be similar for dogs with urinary tract disease.

  13. Oxidative stress in gills of limpets from the Beagle Channel: comparison with limpets from the Antarctic

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    Gabriela Malanga


    Full Text Available The aim of this work was to study the oxidative profile of gills of two limpet species (Nacella (Patinigera magellanica and Nacella (Patinigera deaurata (Gmelin, 1971 exposed to different environmental conditions. Due to the tidal characteristics of the Beagle Channel, N. magellanica are exposed to air twice daily for 3 to 5 hours each time, whereas N. deaurata are exposed to air for 3 hours only during spring tides. The different regime of exposure includes extreme temperatures under 0ºC during winter and more than 20°C in summer for N. magellanica, whereas N. deaurata are usually covered by more than 0.3 m of water at 4°C in winter and 11°C in summer. No significant differences were found between the two molluscs regarding the oxygen uptake, the content of ?-tocopherol and ?-carotene and the activities of the antioxidant enzymes catalase and superoxide dismutase. Lipid peroxidation in gills was estimated as the content of lipid radicals, assessed by electron paramagnetic resonance (EPR. Lipid radical content and total iron content were respectively 80.6 and 62% lower in N. magellanica than in N. deaurata. A typical EPR spectrum of ascorbyl radical in gills from both limpets was observed. Both the ascorbyl radical content and the ascorbyl radical content/ascorbate content ratio were significantly lower in N. magellanica than in N. deaurata. In the Antarctic Nacella concinna inhabits all levels of the littoral zone. Limpets at the highest level in the intertidal showed significantly increased activities of both catalase and superoxide dismutase as compared to their intertidal and subtidal relatives. Thus, it seems that Antarctic high intertidal conditions, involving regular exposure to air and presumably also thermal stress on sunny days during the Antarctic summer, cause a necessity for N. concinna to ward off higher oxygen radical species production by increasing its antioxidant defence. Taken as a whole, the data presented here indicate

  14. Mercado de tierras en un ejido mexicano: El caso de Campos, en Manzanillo, Colima, 1994-2013

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    Francisco Javier Verduzco Miramón


    Full Text Available La reforma al artículo 27 constitucional de 1992 convirtió a los ejidatarios en propietarios de la tierra que trabajaban, condición reforzada por el Programa de Certificación de Derechos Ejidales (Procede que, en 1994, les otorgó títulos parcelarios y de propiedad. De manera colateral, con estas políticas neoliberales se dinamizó el mercado de tierras y, con ello, se facilitó la inversión nacional y extranjera en el territorio mexicano. En el caso de Manzanillo, particularmente en el ejido de Campos, se instaló una planta de almacenamiento y distribución de gas licuado de petróleo y otra de tratamiento de gas natural licuado, más un gasoducto que conecta a la ciudad portuaria con Guadalajara, Jalisco. El objetivo principal de este artículo, es mostrar cómo las reformas constitucionales decretadas hace poco más de dos décadas, en conjunto con factores globales y locales, en la actualidad han intensificado el mercado de tierras en el ejido de Campos, facilitando —aún más— la inversión capitalista ya existente. La información que se presenta en la investigación se obtuvo principalmente de las entrevistas con algunos ejidatarios de Campos, como resultado de trabajo etnográfico realizado en distintos momentos por ambos autores desde el año 2011 hasta 2013.

  15. Geoprocesamiento aplicado al analisis del uso de la tierra en el municipio de San Pedro de Ycuamandyyú, Paraguay.

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    Oscar Agustín Torres Figueredo


    Full Text Available El municipio de San Pedro de Ycuamandyyú está ubicado en el noroeste de la región oriental del Paraguay. Los objetivos de este trabajo constituyen la elaboración y el análisis del mapa del uso de la tierra para la planificación de actividades forestales en la zona, para los cuales se utilizaron técnicas de cartografía, sensores remotos y (SIG Sistemas de Informaciones Geográficas, que posibilitaron el análisis de informaciones provenientes de imágenes satelitales LANDSAT TM 5, de cartas topográficas y de (GPS Sistema de Posicionamiento Global, que permitió el procesamiento de datos en el programa Idrisi 2.0 para la confección de un mapa que posibilitó el análisis sobre la situación del uso de la tierra en el municipio. Se distinguió categorías predominantes como praderas altas o campos naturales, uso agropecuario y praderas bajas o bañados, siendo la cobertura forestal con valor inferior al 25%. Se concluyó que el municipio presenta bastantes áreas de campos naturales y uso agropecuario que podrían utilizarse para actividades de reforestación, sea con especies nativas o exóticas de rápido crecimiento con la finalidad de obtener valores de cobertura forestal en equilibrio con las demás categorías de uso de la tierra.


    Directory of Open Access Journals (Sweden)

    Oscar Agustín Torres Figueredo


    Full Text Available El municipio de San Pedro de Ycuamandyyú está ubicado en el noroeste de la región oriental del Paraguay. Los objetivos de este trabajo constituyen la elaboración y el análisis del mapa del uso de la tierra para la planificación de actividades forestales en la zona, para los cuales se utilizaron técnicas de cartografía, sensores remotos y (SIG Sistemas de Informaciones Geográficas, que posibilitaron el análisis de informaciones provenientes de imágenes satelitales LANDSAT TM 5, de cartas topográficas y de (GPS Sistema de Posicionamiento Global, que permitió el procesamiento de datos en el programa Idrisi 2.0 para la confección de un mapa que posibilitó el análisis sobre la situación del uso de la tierra en el municipio. Se distinguió categorías predominantes como praderas altas o campos naturales, uso agropecuario y praderas bajas o bañados, siendo la cobertura forestal con valor inferior al 25%. Se concluyó que el municipio presenta bastantes áreas de campos naturales y uso agropecuario que podrían utilizarse para actividades de reforestación, sea con especies nativas o exóticas de rápido crecimiento con la finalidad de obtener valores de cobertura forestal en equilibrio con las demás categorías de uso de la tierra.

  17. Geoprocesamiento aplicado al analisis del uso de la tierra en el municipio de San Pedro de Ycuamandyyú , Paraguay

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    Oscar Agustín Figueredo Torres


    Full Text Available El municipio de San Pedro de Ycuamandyyú está ubicado en el noroeste de la región oriental del Paraguay. Los objetivos de este trabajo constituyen la elaboración y el análisis del mapa del uso de la tierra para la planificación de actividades forestales en la zona, para los cuales se utilizaron técnicas de cartografía, sensores remotos y (SIG Sistemas de Informaciones Geográficas, que posibilitaron el análisis de informaciones provenientes de imágenes satelitales LANDSAT TM 5, de cartas topográficas y de (GPS Sistema de Posicionamiento Global, que permitió el procesamiento de datos en el programa Idrisi 2.0 para la confección de un mapa que posibilitó el análisis sobre la situación del uso de la tierra en el municipio. Se distinguió categorías predominantes como praderas altas o campos naturales, uso agropecuario y praderas bajas o bañados, siendo la cobertura forestal con valor inferior al 25%. Se concluyó que el municipio presenta bastantes áreas de campos naturales y uso agropecuario que podrían utilizarse para actividades de reforestación, sea con especies nativas o exóticas de rápido crecimiento con la finalidad de obtener valores de cobertura forestal en equilibrio con las demás categorías de uso de la tierra.


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    Salvador Salort Vives


    Full Text Available El presente artículo pretende analizar los cambios recientes ocurridos en el mercado de la tierra en dos municipios del litoral de la provincia de Alacant, EL VERGER y ELS POBLETS cuyos rasgos definitorios son: un índice de movilidad moderado; un predominio de los jubilados y pensionistas en cuanto a los agentes vendedores y una mayor divers ificación en los agentes compradores. Los móviles de los primeros obedecen a una crecien te incertidumbre sobre el futuro de sus explotaciones agrarias, la escasez y grado de salinidad del agua y en el cas o de ELS POBLETS los altos precios que rigen los intercambios de la tierra para uso no agrícola. Ello está generando un cambio en la mentalidad de los agricultores, ahora más proclives a desprenderse de las tierras. Los móviles de los agentes compradores se orientan a conservar o ampliar el patrimonio familiar o invertir en un sector considerado “seguro”. En definitiva, aunque subsiste un con tinuado proceso de fragmentación del suelo agrícola, se constata la formación de propiedades de dimensiones superiores a 2 Ha cuyos propietarios son no agricultores; por otra parte la presión residencia l en ELS POBLETS está produciendo un fuerte impacto en la organización del espacio rural por la vía de la diversificación de los usos del suelo.

  19. Entendiendo un programa de reparación: reconstrucción del proceso de creación e implementación de familias en su tierra – FEST– El caso del municipio de La Palma, Cundinamarca


    García Cadavid, Laura Andrea


    A partir de la reconstrucción del proceso de creación e implementación del programa presidencial para la reparación a población desplazada Familias En Su Tierra, se exploran las dificultades y retos que enfrenta la Ley de Víctimas y Restitución de Tierras.

  20. Revestimientos especiales para diques y canales

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    Zorzi, Silvano


    Full Text Available This paper summarizes the possibilities and advantages of adopting special facings for dykes and canals, and generally for all large hydraulic works, where waterproofing is of paramount importance. Technical advances in recent years have made it possible to prefabricate many facing units used in these types of works; large slabs, made in reinforced and prestressed concrete, are flexible, and watertight. Although there are many possibilities and types of facing treatments, the one described here is outstanding. It consists of narrow slabs, highly flexible, placed transversally with respect to the canal axis. They are attached with cement mortar, and the joints are finally sealed with a special mortar, called «Emboco». In this article a description is also given of a series of projects, where facing treatments have been used, which are now successfully in service. Finally some general and simple advise is given on the best procedure to apply these facing treatments in the most effective and economic manner.En este trabajo se resumen las posibilidades y ventajas que ofrecen los revestimientos especiales de diques y taludes de canales y, en general, en todas las grandes obras hidráulicas, en que la impermeabilización es de mayor importancia al tratar de conservar los caudales iniciales o la retención de aguas embalsadas, según los casos. Los progresos de las técnicas modernas, en particular la prefabricación, han permitido este tipo de revestimientos con losas de gran longitud, extremadamente flexibles e impermeables, de hormigón armado y pretensado. Aunque son muchas las posibilidades y tipos de revestimiento, destaca el que a continuación se expone: consiste en placas o losas estrechas, de gran flexibilidad, colocadas transversalmente al eje del canal sobre tongadas de mortero de cemento, y cuyas juntas se sellan, finalmente, con un mortero especial llamado «Emboco». Complementan la exposición teórica del método una serie de

  1. Capacidad del uso de la tierra y los cambios en la cuenca del río Nosara, Guanacaste, 1979 - 2006


    Aurora Hernández Ulate


    En la cuenca del río Nosara, en la Región Chorotega de Costa Rica, el uso de la tierra se ha transformado intensamente en los últimas tres décadas.Una sobreposición de la cobertura de la tierra, de 1979, con la capacidad de uso permitió observar que en la cuenca el 80% del área se encontraba en una condición apropiada de uso, para 1992 solo tenía esta condición el 46,9% de la tierra y en el período 2004-2006 representó 34% del área de la cuenca. El bosque es la cobertura que más sufrió con la...

  2. Three distal root canals in mandibular first molar with different canal configurations: Report of two cases and literature review

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    Parul Bansal


    Full Text Available With the increasing number of reports of aberrant root canal morphology, the clinician needs to be aware of the variable anatomy. Various case reports have been published with the finding of middle mesial canal in mandibular first molar, however finding of three distal canals in distal roots of mandibular first molar is rare. This article reports endodontic management of two mandibular first molars presented with three distal canals present in a single distal root (Sert and Bayirli type XVIII and distal and distolingual root.

  3. La presión demográfica sobre la tierra en Toribío, Cauca

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    Jairo Alexander Castaño López


    Full Text Available El fenómeno de la recuperación de la tierra por parte de los indígenas nasa, de la región norte del Cauca, fundamentalmente en los municipios de Toribío, Jambaló, Caloto, Santander de Quilichao y Corinto, comenzó en la década de 1970 y continúa en la actualidad, con sucesivas tomas en la zona plana de los municipios de Caloto y Corinto. Uno de los argumentos de las organizaciones indígenas es el creciente número de familias que no tienen acceso a la tierra, ni por la herencia familiar ni por la asignación de los cabildos. Este artículo explora el proceso de cambio sociodemográfico que ha atravesado el municipio de Toribío en los últimos veintiún años, a partir de un análisis comparativo de los principales resultados de los censos de población del DANE de 1993 y el 2005 y de algunos resultados de la Encuesta piloto experimental indígena nasa sobre el buen vivir (Encuesta Nasa, 2014. Con base en esta última, se examina la relación existente entre las condiciones sociodemográficas y el acceso a la tierra de las Unidades Domésticas y de Producción Nasa (UDPN de los resguardos San Francisco, Tacueyó y Toribío, que componen el municipio de Toribío. Se sugiere que los cambios sociodemográficos recientes (crecimiento general de la población y aumento de las cohortes de edad productiva, en un territorio que no varía en extensión, han llevado al “estrangulamiento” de la tierra disponible en el municipio.

  4. Perfil epidemiológico del accidente ofídico en las tierras bajas de Guatemala


    Dennis Guerra-Centeno


    Se describe el perfil epidemiológico del accidente ofídico en las tierras bajas de Guatemala a partir del análisis de 305 expedientes de casos atendidos en los hospitales regionales de Escuintla y San Benito, Petén, entre 2008 y 2013. De los 305 casos, 169 correspondieron al Hospital Regional de Escuintla y 136 al Hospital Regional de San Benito Petén. Los casos del Hospital Regional de Escuintla correspondieron a pacientes provenientes de los departamentos de Escuintla, Santa Rosa, Chimalten...

  5. SAFEGUARD OF TRADITIONAL MUSIC IN TIERRA CALIENTE Preservation and development programs of cultural patrimony of a region

    Directory of Open Access Journals (Sweden)

    Alejandro Martínez de la Rosa


    Full Text Available Traditional music of Mexico is in process of change andmuch of its wealth still is unknown, and so is necessary toinvestigate and to spread the variants, moreoverestablishing development cultural programs, therefore inthis article we revise three initiatives promoted for differentcultural organizations in last year’s, creates for preservingand revitalizing the musical patrimony of Tierra Caliente ofMichoacan region, and we developed a critical analysisfrom results of every one programs. The reflection aboutcultural problem force to continue the relationship betweenall culture agents of these projects, as soon as to increasethe promotion and spread in local ambit where the musicaltradition arises.

  6. Disilicatos de tierras raras simples y sus soluciones sólidas: estructura cristalina y propiedades físicas


    Fernández Carrión, Alberto José


    La familia de los disilicatos de tierras raras (de fórmula general RE2Si2O7) exhibe, a presión atmosférica, un elevado polimorfismo con la temperatura (hasta 7 formas diferentes), cuyas estructuras y campos de estabilidad fueron bien definidos por Felsche.[1] Es bien sabido que esta familia de compuestos pueden formar soluciones sólidas entre ellos, de tipo (RE,RE`)2Si2O7, cuyos campos de estabilidad vienen predichos por el criterio del radio.[2] Dicho criterio establece que las regiones de e...

  7. Tierra y comunidad. un problema irrsesuelto. El caso del altiplano cundiboyacense (Virrenaito de la Nueva Granada 1750-1800

    Directory of Open Access Journals (Sweden)

    Heraclio Bonilla


    Full Text Available Diana Bonnett Vélez, Tierra y comunidad. Un problema irresuelto. El caso del altiplano cundiboyacense (Virreinato de la Nueva Granada 1750-1800. Bogotá: Instituto Colombiano de Antropología e Historia Universidad de los Andes, 2002, 318 páginas. El libro de la profesora Diana Bonnett, inicialmente presentado como tesis doctoral ante el Colegio de México, constituye un aporte al esclarecimiento de esta problemática, a partir del análisis de lo ocurrido en la segunda mitad del siglo XVIII en las áreas de Tunja y Santafé de Bogotá.

  8. Tierra, nación y construcción del Estado en el Paraguay del siglo XIX

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    Ignacio Telesca


    Full Text Available El texto se plantea reflexionar sobre la sociedad paraguaya previa a la guerra en tanto su identidad como nación. Identidad implicada con el relacionamiento con la tierra y la construcción del Estado. Se plantea que esta identidad más que con el Paraguay como nación se relacionaba con su terruño, con su comunidad local, a pesar del incipiente proceso de construcción de un Estado moderno por Carlos Antonio López.

  9. Curva de retención suelo-agua e inicio de monitoreo en Tierra Blanca Joven (TBJ)


    José A. Chávez; Reynaldo López; Lubomir Kopecky; José Landaverde


    En El Salvador durante la época de lluvias o cuando ocurren terremotos, las áreas cubiertas por las tefras volcánicas Tierra Blanca Joven (TBJ) sufren movimientos de ladera, licuefacción y erosión provocando pérdidas ambientales, sociales y económicas importantes. Para iniciar la caracterización de estos suelos parcialmente saturados, valores de succión de una unidad de caída de TBJ fueron obtenidos con la olla de presión, centrífuga y papel filtro para construir la Curva de Retención Suelo-A...

  10. Benidorm Tierra Adentro: un nuevo producto turístico basado en las dinámicas de complementariedad territorial


    Díez Santo, Daniel


    Propuesta enviada al concurso de ideas del XII Foro Internacional de Turismo de Benidorm. RETAR AL FUTURO: LA REINVENCIÓN DE LOS DESTINOS TURÍSTICOS (23-24 de octubre de 2008). Benidorm Tierra Adentro es una propuesta para el desarrollo de un nuevo producto turístico basado en las dinámicas de complementariedad territorial litoral-interior. La movilización de flujos turísticos establece relaciones simbióticas entre Benidorm y los municipios del interior provincial, aportando beneficios dir...

  11. Cartografía Mediante Imágenes Landsat De Suelos Salinos En La Tierra De Medina (Valladolid)


    García Rodríguez, M. P.; Pérez González, M. E.


    The main goal of this study is the mapping of saline soils (solonchaks, solonetzs and luvisols with salic phases) in «Tierra de Medina» (Valladolid) using images of the TM and ETM sensors of the Landsat satellites. The spectral signatures of these soils show very high digital values, which allows to differentiate them from other types of soils and superficial covers. The highest values correspond to those which have salt efflorescences and the lowest values to soils affected by hydromorphic p...

  12. Cartografía mediante imágenes Landsat de suelos salinos en la tierra de Medina (Valladolid)


    García Rodríguez, M. P.; Pérez González, M. E.


    El objetivo del estudio es cartografiar los suelos salinos (solonchaks, solonetzs y luvisoles con fases sálicas) en la Tierra de Medina (Valladolid) utilizado imágenes de los sensores TM y ETM de los satélites Landsat. Las signaturas espectrales de estos suelos muestran valores digitales muy altos, lo que permite diferenciarlos de otros tipos de suelos y cubiertas superficiales. Los valores más altos corresponden a los que tienen eflorescencias salinas en superficie y los más bajos a los suel...

  13. Difference fractal surfaces poured earth floors Tamaulipas / Diferencia fractal en superficies de tierra vertida con suelo de Tamaulipas

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    Edgardo Jonathan Suárez Dominguez


    Full Text Available Poured earth is a sustainable construction and economically feasible technique to develop in Tamaulipas, by the materials availability and traditional manufacturing procedures uses. There are several variables to be considered in these elements for their properties, among them it can be found roughness and porosity analysis which are important because they are related to material mechanical resistance and durability. This study aimed to characterize solid surfaces using fractal dimension to know its uniformity and porosity, compared with a concrete surface. Solids were obtained from poured earth of two combinations of soils stabilized with cement from the state of Tamaulipas. We found that a surface of a sample, obtained with ground, is more uniform than poured concrete surface, and that fractal dimension is higher while porosity increases; results suggest that this is because of the presence of clay in the poured earth mixtures. La tierra vertida es una técnica constructiva sustentable y económicamente viable para desarrollarse en Tamaulipas, por la disponibilidad de materiales y procedimientos de fabricación similares a los tradicionales. Son diversas las variables que deben estudiarse en estos elementos para conocer sus propiedades, entre las que se encuentran la rugosidad y la porosidad, las cuales son importantes debido a su estrecha relación con la resistencia mecánica y durabilidad del material estudiado. El presente trabajo tuvo por objetivo caracterizar superficies sólidas a partir de la dimensión fractal para conocer su uniformidad y porosidad, comparándola con una superficie de concreto. Los sólidos fueron obtenidos a partir de tierra vertida conformada de dos combinaciones de suelos estabilizadas con cemento provenientes del estado de Tamaulipas. Se encontró que una superficie de tierra vertida es menos irregular que una superficie de concreto además de tener una menor porosidad reflejada en una menor dimensión fractal

  14. Estructura de remanentes forestales en las tierras semiáridas del sur de Sudamérica


    Muñoz Garachana, Diego


    Ante el problema de la expansión agrícola en las tierras secas del sur de Sudamérica se plantea la necesidad de estudiar la heterogeneidad generada en el paisaje como consecuencia de dicho proceso. Concretamente en Argentina, esta tendencia no cambia, experimentando las masas del Chaco Seco y Espinal una acelerada deforestación. En estos paisajes se alternarán grandes masas forestales y pequeños fragmentos de bosque inmersos en una matriz agrícola, cumpliendo un rol fundamental...

  15. Patrimonio y producción en las tierras de los betlemitas : Córdoba, 1600-1870


    Ferreyra, Ana Inés


    En este trabajo pretendemos aproximarnos al complejo mundo rural cordobés y observar otras formas de tenencias de la tierra, con sus prácticas de producción y trabajo, los diversos actores que se mueven dentro y fuera de la unidad, sus trayectorias personales y empresarias y las múltiples relaciones sociales que los vincularon. Procuraremos ampliar nuestra mirada hacia el contexto en que operaron en el marco regional e interregional. A los fines de comparar y observar los cambios y permanenci...

  16. Medición de la resistencia de la tierra en los circuitos eléctricos


    Vásquez Novoa, Gustavo Enríque


    La mayoría de las personas que conectan un toma corriente para una Pc, saben que esta debe ser polarizada pero el problema que enfrentan es: ¿cómo puede verificarse que el valor de la resistencia eléctrica de la tierra en la conexión de polarización que se ha realizado en el circuito eléctrico está de acuerdo a lo normado? En este articulo se presenta una comparación entre tres alternativas para realizar esta verificación: 1. un probador desarrollado en ITCA-FEPADE, que se conecta directament...

  17. Modelos del planeta Tierra en escolares rurales de Chile / Planet Earth models about students in rural schools from Chile

    Directory of Open Access Journals (Sweden)

    Paula Alonqueo Boudon


    Full Text Available RESUMEN El presente estudio tuvo como objetivo identificar los modelos del planeta Tierra en escolares mapuches y no mapuches de procedencia rural. Los participantes fueron 40 escolares distribuidos en dos grupos de edad, quienes respondieron a una tarea cognitiva que indaga la representación de la forma del planeta Tierra. En base al grado de acuerdo con la representación científica, cada participante fue categorizado en uno de cuatro modelos del planeta Tierra. El modelo 4, concordante con el conocimiento científico, no fue observado, pues la mayoría de los participantes se concentra en el modelo 3 en el que coexisten conocimientos previos con algunos elementos científicos. En los niños no mapuches se aprecia que el modelo del planeta Tierra se ajusta a los significados científicos a medida que aumenta el conocimiento escolar. Por el contrario, en los niños mapuches no se observa esta tendencia. Se discute el papel de la cultura y la enseñanza en el aprendizaje del modelo científico del planeta. ABSTRACT The aim of this study was to identify planet Earth models in mapuches and non mapuches students of rural origin. The participants were 40 students divided into two age groups who responded to a cognitive task which explores the representation of the shape of the planet Earth. Based on the degree of agreement with the scientific representation, each participant was categorized into one of four models of planet Earth. Model 4, consistent with the scientific knowledge was not observed because the majority of the participants were concentrated in Model 3. In non mapuche children, it is observed that the model of the planet Earth is adjusted to the scientific meaning in accordance with the increase of school knowledge. On the other hand, this trend is not observed in mapuche children. The role of culture and teaching is discussed in the learning of planet scientific model.

  18. Estudio de la estructura cortical en la Isla de Tierra del Fuego a partir de datos sismológicos


    Buffoni, C.; Schimmel, Martin; Sabbione, N.C.; de Rosa, M. L.


    La Isla de Tierra del Fuego (TdF) se encuentra ubicada en el extremo sur de la Cuenca de Magallanes, donde el borde transformante entre la Placa de Scotia y la Sudamericana define el Sistema de Fallas Magallanes-Fagnano (MFS), cuya falla principal tiene un movimiento sinestral. Con el fin de obtener información de la corteza, se realizó un análisis de funciones receptoras (FR) a partir de datos registrados en cinco estaciones sismológicas instaladas en la Isla. Una FR es el resultado de un pr...

  19. Tierras Bajas de Bolivia: II Jornadas de Antropología, Historia y Arqueología


    Combès, Isabelle


    Las II Jornadas de Antropología, Historia y Arqueología de las tierras bajas de Bolivia y áreas adyacentes se desarrollaron del 14 al 16 de octubre en Santa Cruz de la Sierra, en los locales del Museo de Historia de la Universidad Autónoma Gabriel René Moreno (UAGRM). Este encuentro fue organizado por el Museo de Historia a través del Centro de Investigaciones Históricas y Antropológicas (CIHA), del Instituto Francés de Estudios Andinos, del programa de posgrado en Historia de la Universidad...

  20. Water Environment Evolution along the China Grand Canal (United States)

    Mao, F.; Wu, Y. X.; Yang, B. F.; Li, X. J.


    The China Grand Canal is one of the earliest canals in the world, having lasted for nearly 3000 years. Even its section canals have a rich history, such as the North-South Grand Canal that was established during the Sui Dynasty, whereas the Beijing-Hangzhou Canal was excavated during the Yuan Dynasty and the east line of the South-to-North Water Diversion. As one of the longest in the world, the China Grand Canal's total length is over 3500 kilometers. This length includes the navigable, unnavigable, and underground sections. Making the best use of situations and according to local conditions, the Chinese people harmoniously constructed the Beijing-Hangzhou Canal with nature. Tens of millions of workers took nearly 3000 years to complete the great shipping system. Navigable sections still exist for up to 900 kilometers and the volume of freight traffic is approximately 300 million tons. The canal remains the main logistical channel of the North-to-South Coal Transportation, South-to-North Water Diversion, and resources circulation. To date, China is promoting the success of heritage application. Part of these efforts is the declaration of the China Grand Canal as a World Cultural Heritage by 2014. In addition, the east route of the South-to-North Water Transfer project is planned to be navigable by 2016. The ancient Beijing-Hangzhou Grand Canal will usher in the new ecological civilization and cultural revival along the canal. This paper presents technical methods of water environment evolution research on the river system, river, and water quality along the Beijing-Hangzhou Canal through the integration of historical literature and modern remote sensing image data. The study carried out water environment investigation and analysis along the Beijing-Hangzhou canal by using ETM, SPOT image data, and GPS measurement data. Spatial and temporal evolution characteristics and regulations of the Beijing-Hangzhou Grand Canal regional water environment in the span of 3000

  1. Root canal treatment of mandibular second premolar tooth with taurodontism

    Directory of Open Access Journals (Sweden)

    Vujašković Mirjana


    Full Text Available INTRODUCTION Taurodontism is a morphoanatomical change in the shape of a tooth. An enlarged body of a tooth with smaller than usual roots is a characteristic feature. Internal tooth anatomy correlates with this appearance, which means that a taurodontal tooth has a large pulp chamber and apically positioned furcations. This dental anomaly may be associated with different syndromes and congenital discoders. CASE OUTLINE The case report presents the patient of a rare case of taurodontism in the mandibular second premolar with chronic periodontitis. Endodontic treatment was performed after dental history and clinical examination. Special care is required in all segments of endodontic treatment of a taurodontal tooth from the identification orifice, canal exploration, determining working length, cleaning and shaping and obturation of the root canal. Precurved K-file was used for canal exploration and location of the furcation. One mesial and one distal canal with the buccal position were identified in the apical third of the root canal. The working lengths of two canals were determined by radiographic interpretation with two K-files in each canal and verified with the apex locator. During canal instrumentation, the third canal was located in the disto-lingual position. The working length of the third canal was established using the apex locator. CONCLUSION Thorough knowledge of tooth anatomy and its variations can lead to lower percentage of endodontic failure. Each clinical case involving these teeth should be investigated carefully, clinically and radiographically to detect additional root canals. High quality radiographs from different angles and proper instrumentarium improve the quality of endodontic procedure.

  2. [Root canal treatment of mandibular second premolar tooth with taurodontism]. (United States)

    Vujasković, Mirjana; Karadzić, Branislav; Miletić, Vesna


    Taurodontism is a morphoanatomical change in the shape of a tooth. An enlarged body of a tooth with smaller than usual roots is a characteristic feature. Internal tooth anatomy correlates with this appearance, which means that a taurodontal tooth has a large pulp chamber and apically positioned furcations. This dental anomaly may be associated with different syndromes and congenital discoders. The case report presents the patient of a rare case of taurodontism in the mandibular second premolar with chronic periodontitis. Endodontic treatment was performed after dental history and clinical examination. Special care is required in all segments of endodontic treatment of a taurodontal tooth from the identification orifice, canal exploration, determining working length, cleaning and shaping and obturation of the root canal. Precurved K-file was used for canal exploration and location of the furcation. One mesial and one distal canal with the buccal position were identified in the apical third of the root canal. The working lengths of two canals were determined by radiographic interpretation with two K-files in each canal and verified with the apex locator. During canal instrumentation, the third canal was located in the disto-lingual position. The working length of the third canal was established using the apex locator. Thorough knowledge of tooth anatomy and its variations can lead to lower percentage of endodontic failure. Each clinical case involving these teeth should be investigated carefully, clinically and radiographically to detect additional root canals. High quality radiographs from different angles and proper instrumentarium improve the quality of endodontic procedure.

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  11. Estimación del tiempo de iluminación solar sobre la tierra mediante un modelo analítico: un escenario fértil para enseñar física


    Talero, Paco; Santana, Fernanda; Mora, César


    Se formuló un modelo analítico que permitió estimar el tiempo de iluminación solar sobre la Tierra para cualquier fecha del año y cualquier latitud, el modelo tomó la oblicuidad de la eclíptica constante, los rayos de luz paralelos, la Tierra esférica y el movimiento de la Tierra circular uniforme, también mostró un contexto de la astronomía para enseñar física básica. Se relacionó el movimiento de la Tierra alrededor del Sol con el movimiento del plano de luz proyectado sobre la Tierra, lueg...

  12. Organización territorial y distribución de la tierra en la comunidad de San Felipe Otlaltepec, Puebla, México


    Jesús García Maceda; Ángel Bustamante González; Samuel Vargas López; Juan de Dios Guerrero Rodríguez; José Isabel Olvera Hernández


    San Felipe Otlaltepec, una comunidad indígena Popoloca del estado de Puebla, organiza su territorio en secciones, una unidad territorial colonial. Esta organización es la base de la apropiación del territorio urbano y de las tierras agrícolas. Con entrevistas y fotografías aéreas, se construyó un modelo de la conformación original y actual de las viviendas de las secciones y de la apropiación de la tierra, para su comparación. Actualmente, se observa una mezcla de viviendas de diferentes secc...

  13. Evaluación estructural del efecto del mortero de pega sobre probetas de muro de ladrillo de tierra compactada bajo esfuerzos de comprensión axial


    Pinos Coronel, Alex Vladimiro


    La presente investigación gira en torno a la obtención de conocimientos técnicos para una correcta fabricación y utilización de los Bloques de tierra compactada o BTC como alternativa a los ladrillos de arcilla cocida. Se analiza las granulometrías y tipos de suelos que mejor resultado han dado en pruebas realizadas por distintos investigadores y que ahora forman parte de algunos códigos de construcción en tierra. También se toca el tema de la determinación de humedad óptima de compactació...

  14. Endodontic management of permanent mandibular left first molar with six root canals

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    Sachin Gupta


    Full Text Available The endodontic treatment of a mandibular molar with aberrant canal configuration can be diagnostically and clinically challenging. This case report presents the treatment of a mandibular first molar with six root canals, of which three canals were located in the mesial root and three in distal root. Third canals were found between the two main root canals. This case presents a rare anatomic configuration and points to the importance of expecting and searching for additional canals.

  15. Visibility of the central canal on MRI

    Energy Technology Data Exchange (ETDEWEB)

    Petit-Lacour, M.C.; Lasjaunias, P.; Iffenecker, C.; Benoudiba, F.; Hadj Rabia, M.; Doyon, D. [Service de Neuroradiologie, Faculte de Paris Sud (France); Hurth, M. [Department of Neurosurgery, Faculte Paris Sud, Kremlin-Bicetre (France)


    The central canal of the spinal cord is present at birth and becomes progressively obliterated. Cadaver studies have shown that it may persiste partially or completely. To our knowledge, this entity has not been described on MRI. We reviewed 794 MRI studies of the spinal cord, and found 12 patients (aged 14 to 65 years) who had an intramedullary cavity. The cavity was at the junction of the ventral {sup 1}/{sub 3} and dorsal {sup 2}/{sub 3} of the spinal cord, except at the level of the lumbar enlargement, where it was central. It was filiform in most cases, although sometimes fusiform (3 to 4 mm in diameter), and had regular contours. The cavity were thoracic in 69 % of cases. The clinical features were totally unrelated to the image, and there were no anatomical factors (Chiari malformation, dysraphism) predisposing to syringomyelia. The images were perfectly compatible with a persistent central canal, which we interpret as a variant of normal anatomy. Therefore it is important to regard these findings as normal, to avoid unnecessary treatment and follow-up. (orig.)

  16. Root canals-from concretion to patency

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    Chandrakar Chaman


    Full Text Available Teeth with calcification provide an endodontic treatment challenge; traumatized teeth usually develop partial or total pulpal obliteration which is characterized by apparent loss of the pulp space radiographically and a yellow discoloration of the clinical crown. Since only 7-27% of such teeth develop pulp necrosis with radiographic signs of apical periodontitis, it is difficult to decide whether to treat these teeth immediately upon detection of the pulpal obliteration or to wait until signs and symptoms of pulp and/or apical periodontitis occur. This article reviews the etiology, prevalence, classification, mechanism, diagnosis as well as treatment options for teeth with pulp obliteration and the various management approaches and treatment strategies for overcoming potential complications. A search of articles from "PubMed" and "Medline" from 1965 to present was done with the keywords dental trauma, discoloration, pathfinding instruments, pulp canal obliteration, and root canal treatment was conducted. A total of 94 abstracts were collected, of which 70 relevant articles were read and 31 most relevant articles were included in this article.

  17. Beagle model used in a tissue tolerance study of the response of normal and surgically manipulated liver to single high-dose intraoperative radiotherapy

    NARCIS (Netherlands)

    Cromheecke, M; Meijer, D; Hietkamp, J; Vermeij, J; vanGinkel, RJ; Hoekstra, HJ


    To investigate the feasibility of delivering a single large dose of intraoperative electron beam radiotherapy (IORT) to the liver of clinically normal and partially hepatectomized beagles, an experimental study was designed, The purpose of the study was to obtain dose guidelines for the delivery of

  18. Assessment of three root canal preparation techniques on root canal geometry using micro-computed tomography: In vitro study

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    Shaikha M Al-Ali


    Full Text Available Aim: To assess the effects of three root canal preparation techniques on canal volume and surface area using three-dimensionally reconstructed root canals in extracted human maxillary molars. Materials and Methods: Thirty extracted Human Maxillary Molars having three separate roots and similar root shape were randomly selected from a pool of extracted teeth for this study and stored in normal saline solution until used. A computed tomography scanner (Philips Brilliance CT 64-slice was used to analyze root canals in extracted maxillary molars. Specimens were scanned before and after canals were prepared using stainless steel K-Files, Ni-Ti rotary ProTaper and rotary SafeSiders instruments. Differences in dentin volume removed, the surface area, the proportion of unchanged area and canal transportation were calculated using specially developed software. Results: Instrumentation of canals increased volume and surface area. Statistical analysis found a statistically significant difference among the 3 groups in total change in volume (P = 0.001 and total change in surface area (P = 0.13. Significant differences were found when testing both groups with group III (SafeSiders. Significant differences in change of volume were noted when grouping was made with respect to canal type (in MB and DB (P < 0.05. Conclusion: The current study used computed tomography, an innovative and non destructive technique, to illustrate changes in canal geometry. Overall, there were few statistically significant differences between the three instrumentation techniques used. SafeSiders stainless steel 40/0.02 instruments exhibit a greater cutting efficiency on dentin than K-Files and ProTaper. CT is a new and valuable tool to study root canal geometry and changes after preparation in great details. Further studies with 3D-techniques are required to fully understand the biomechanical aspects of root canal preparation.

  19. Endodontic management of mandibular canine with two canals

    Directory of Open Access Journals (Sweden)

    Nidhi Shrivastava


    Full Text Available Endodontic treatment may sometimes fail because morphological features of the tooth adversely affect the treatment procedures. Many investigators have reported the anatomical variations associated with mandibular canines. Mandibular canines are recognized as usually having one root and one root canal in most cases. This case report describes a clinical case of mandibular canine with two canals. Human mandibular canines do not present internal anatomy as simple as could be expected; there are such canines with a single root and two canals, two roots or fused roots. The existence of mandibular canines with more than one root canal is a fact that clinicians ought to keep in mind, in order to avoid failure during endodontic treatment. In spite of the low incidence of lower canines with one root and two canals, this possibility cannot be forgotten, inasmuch as the presence of a second canal in these teeth leads to difficulties in endodontic treatment. The precise knowledge of the dental endocanalicular system′s anatomy is essential in the success of the root canal therapy, because the failure to detect the accessories canals and the incomplete radicular obturation leads to the infection of the periapical space, which will ultimately result in the loss of the tooth.

  20. Technical quality of root canal treatment in Taiwan. (United States)

    Chueh, L-H; Chen, S-C; Lee, C-M; Hsu, Y-Y; Pai, S-F; Kuo, M-L; Chen, C-S; Duh, B-R; Yang, S-F; Tung, Y-L; Hsiao, Chuhsing Kate


    To evaluate the current technical quality of root canal treatment (RCT) in Taiwan. A total of 1085 RCT cases, randomly selected from a large sample and representative of the Taiwanese population from April to September 2000, were evaluated by eight endodontic specialists. The qualitative evaluation of RCT cases was based on two variables: length of the root filling and density of the obturation. A root canal with both adequate filling length (the apical termination of the root filling within 2 mm of the radiographic apex) and complete obturation (no lateral or apical canal lumen visible in the apical one-third of the root canal) was defined as having good-quality endodontic work (GQEW). A tooth was defined as having a GQEW when all its canals were categorized as GQEW. From a total of 1867 root canals, overfilling occurred in 235 (12.6%), adequate filling length in 1152 (61.7%), underfilling in 466 (25.0%) and no filling in 12 (0.6%). Of the 1867 root canals, 710 (38.0%) demonstrated complete obturation and 1157 (62%) demonstrated incomplete obturation. GQEW was found in 650 (34.8%) root canals and 329 (30.3%) teeth. The percentage of teeth with GQEW in hospital cases (38.1%) was significantly greater (P RCT in Taiwan were either of inadequate filling length or sealing density.

  1. Lateral line canal morphology and signal to noise ratio (United States)

    Klein, Adrian; Herzog, Hendrik; Bleckmann, Horst


    The lateral line system of fish is important for many behaviors, including spatial orientation, prey detection, shoaling, intra specific communication and entraining. The smallest sensory unit of the lateral line is the neuromast that occurs free standing on the skin and in fluid filled canals. With aid of the lateral line fish perceive minute water motions. In their natural habitat fish are not only faced with biotic water motion but also with the abiotic fluctuations caused by various inanimate sources. The detection of meaningful signals is crucial for survival, and therefore animals should be able to separate meaningful signals from noise. Fishes live in various habitats (e.g. in still water or in running water). Therefore it is not surprising that the number and distribution of neuromasts as well as canal dimension, canal shape and canal branching patterns differ among fish species. We studied how lateral line canal parameters influence the filter properties of lateral line canals. To do so we exposed artificial lateral line canals, equipped with artificial neuromasts (sensors), to the vortex street shed by a submerged cylinder and to air bubble noise. We found that certain canal parameters significantly can enhance the signal to noise ratio.

  2. 33 CFR 117.769 - Black Rock Canal. (United States)


    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Black Rock Canal. 117.769 Section 117.769 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements New York § 117.769 Black Rock Canal. The draws of the...

  3. 33 CFR 117.159 - Grant Line Canal. (United States)


    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Grant Line Canal. 117.159 Section 117.159 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements California § 117.159 Grant Line Canal. The draw of the...

  4. Segmental carpal canal pressure in patients with carpal tunnel syndrome. (United States)

    Ikeda, Kazuo; Osamura, Naoki; Tomita, Katsuro


    To clarify which part of the median nerve is the most compressed and to compare carpal canal pressure with the latency of the sensory nerve potential and the duration of symptoms. Fifteen patients with idiopathic carpal tunnel syndrome were studied using a pressure guidewire system to record canal pressure. The wire was introduced from the distal end of the carpal canal to 2 cm proximal to the distal wrist crease (DWC) and then retracted in 5-mm increments using an image intensifier to guide the progress. A nerve conduction study was performed, and all patients were asked how long the symptoms lasted. Carpal canal pressure was significantly higher 5 to 15 mm distal to the DWC. The most compressed point was 10 mm distal to the DWC, with a pressure of 44.9 +/- 26.4 mm Hg. The correlation coefficient between the highest canal pressure and the latency was 0.393 and between highest canal pressure and duration of symptoms was 0.402. Our study showed that the most compressed part of the median nerve in the carpal canal is 10 mm distal to the DWC. The carpal canal pressure was related to the latency and to the duration of symptoms.

  5. Sexual dimorphism in cervical vertebral canal measurements of ...

    African Journals Online (AJOL)

    Sexual dimorphism in cervical vertebral canal measurements of human foetuses. ... Anatomy Journal of Africa ... Cervical parts of vertebral canal in 30 normal human foetuses was exposed in coronal plane and were divided in groups 1 and 2 which correspond with 2nd and 3rd trimester of pregnancy respectively. Groups 1 ...

  6. Morphology of root canals in lower human premolars | Baroudi ...

    African Journals Online (AJOL)

    Background The knowledge of the root canal morphology and the possible anatomical variations of mandibular premolars are important for the successful endodontic treatment of such cases. The aim of this study was to investigate the presence of two or three root canals in extracted first and second mandibular premolars ...

  7. Reform in Indian canal irrigation: does technology matter?

    NARCIS (Netherlands)

    Narain, V.


    This paper examines the implications of technology - the design of canal irrigation for irrigation management reform. With reference to two different design systems in Indian irrigation - shejpali and warabandi - it shows that the potential for reform varies with the design of canal irrigation.

  8. Identification of non-host semiochemicals for the brown dog tick, Rhipicephalus sanguineus sensu lato (Acari: Ixodidae), from tick-resistant beagles, Canis lupus familiaris. (United States)

    Borges, Lígia Miranda Ferreira; de Oliveira Filho, Jaires Gomes; Ferreira, Lorena Lopes; Louly, Carla Cristina Braz; Pickett, John A; Birkett, Michael A


    Studies have shown that the brown dog tick, Rhipicephalus sanguineus sensu lato, when fed on the beagle breed of dog, Canis lupus familiaris, development negatively affected in comparison with tick development after feeding on the English cocker spaniel breed. Thus leading to the suggestion that beagle dogs are be tick-resistant dogs. Behavioural studies have demonstrated that more ticks are attracted by extracts from cocker spaniels than from beagles and that the odour of beagles is a repellent. To test the hypothesis that resistant hosts produce repellent compounds, we undertook comparative chemical analysis on beagle odour and cocker spaniel extracts using coupled high-resolution gas chromatography-mass spectrometry (GC-MS) and also used Petri-dish and olfactometer behavioural assays to assess the response of ticks to identified non-host compounds. The beagle odour extracts contained almost three times as many chemical compounds as cocker spaniel samples. Several non-host compounds were identified, i.e. 2-hexanone, benzaldehyde, nonane, decane and undecane. In Petri-dish assays, 2-hexanone was repellent at 30 min at concentrations of 0.200 and 0.050 mg cm(-2), whilst at 10 min, the 0.100 mg cm(-2) concentration was repellent. Benzaldehyde repelled ticks at 30 min (0.200 mg cm(-2)) and at 5 min (0.050 mg cm(-2)). Undecane was repellent for R. sanguineus s.l. ticks for the first 5 min at the highest concentration tested. Nonane and decane did not show any significant repellency at any concentration or time evaluated. When 2-hexanone and benzaldehyde were combined, an increase in the repellency rate was observed, with activity comparable or better than N,N-diethyl-3-methylbenzamide (DEET). In olfactometer bioassays, a 1:1 mixture of 2-hexanone:benzaldehyde and DEET were repellent for R. sanguineus s.l. adults at the concentration of 0.200 mg cm(-2). This study identified non-host semiochemicals that mediate avoidance of the beagle dog breed by R. sanguineus s

  9. Traditional and contemporary techniques for optimizing root canal irrigation. (United States)

    Holliday, Richard; Alani, Aws


    Canal irrigation during root canal treatment is an important component of chemo-mechanical debridement of the root canal system. Traditional syringe irrigation can be enhanced by activating the irrigant to provide superior cleaning properties. This activation can be achieved by simple modifications in current technique or by contemporary automated devices. Novel techniques are also being developed, such as the Self-adjusting File (Re-Dent-Nova, Ra'anana, Israel), Ozone (Healozone, Dental Ozone, London, UK), Photoactivated Disinfection and Ultraviolet Light Disinfection. This paper reviews the techniques available to enhance traditional syringe irrigation, contemporary irrigation devices and novel techniques, citing their evidence base, advantages and disadvantages. Recent advances in irrigation techniques and canal disinfection and debridement are relevant to practitioners carrying out root canal treatment.

  10. Hydrology and environmental aspects of Erie Canal (1817-99) (United States)

    Langbein, Walter Basil


    As the first major water project in the United States, the old Erie Canal provides an example of the hydrological and environmental consequences of water development. The available record shows that the project aroused environmental fears that the canal might be impaired by the adverse hydrologic effects of land development induced by the canal. Water requirements proved greater than anticipated, and problems of floods and hydraulic inefficiencies beset navigation throughout its history. The Erie Canal proved the practicality of major hydraulic works to the extent that operations and maintenance could cope with the burdens of deficiencies in design. The weight of prior experience that upland streams, such as the Potomac and Mohawk Rivers, had proved unsatisfactory for dependable navigation, led to a decision to build an independent canal which freed the location from the constraints of river channels and made possible a cross-country water route directly to Lake Erie. The decision on dimensioning the canal prism--chiefly width and depth-involved balance between a fear of building too small and thus not achieving the economic potentials, and a fear of building too expensively. The constraints proved effective, and for the first part of its history the revenues collected were sufficient to repay all costs. So great was the economic advantage of the canal that the rising trend in traffic soon induced an enlargement of the canal cross section, based upon a new but riskier objective-build as large as the projected trend in toll revenues would finance. The increased revenues did not materialize. Water supplies were a primary concern for both the planners and the operators of the canal. Water required for lockage, although the most obvious to the planners, proved to be a relatively minor item compared with the amounts of water that were required to compensate for leakage through the bed and banks of the canal. Leakage amounted to about 8 inches of depth per day. The total


    Directory of Open Access Journals (Sweden)

    Janet Kirilova


    Full Text Available Background: Successful endodontic treatment requires effective biomechanical preparation of the root canals and three-dimensional obturation of the root canal system. This can be achieved only by knowing and identifying the variations in the root canal system of the endodontically treated teeth. The Aim: The aim of this article is to present cases of endodontic treatment of maxillary first premolar with three root canals – different types. Material and Methods: Five clinical cases of successful endodontic treatment of patients with maxillary first premolar and three root canals are described. Result and Discussion: It is noted that good endodontic practice requires good knowledge of dental anatomy and possible variations, accurate X-ray images, as well as use of magnifying equipment. Conclusion: Knowledge of dental anatomy is fundamental for good endodontic practice.

  12. El registro bioarqueológico de Bahía Valentín, sureste de Tierra del Fuego

    Directory of Open Access Journals (Sweden)

    Tessone, Augusto


    Full Text Available En el marco del proyecto Arqueología de Península Mitre: desarrollo científico y puesta en valor del patrimonio cultural aborigen, se han realizado prospecciones tendientes a explorar las propiedades del registro arqueológico de bahía Valentín, ubicada en el sureste de la Isla Grande de Tierra del Fuego. Estas exploraciones posibilitaron la localización de dispersiones de restos óseos humanos en contextos de hallazgo similares: elementos descontextualizados dispuestos en superficie o parcialmente enterrados en sectores de dunas. En esta comunicación examinamos el grado de destrucción y las condiciones de redepositación de estos restos humanos a partir de distintas variables tafonómicas. Estos análisis permitieron indagar sobre la integridad del registro bioarqueológico y comprender, asimismo, los procesos que intervinieron en su formación. Las características principales de la muestra son un alto grado de meteorización y de perdida ósea. Considerando los casos analizados por otros investigadores, se compara la integridad y la frecuencia de hallazgos de restos óseos humanos de bahía Valentín con la registrada en otros sectores de la Isla Grande de Tierra del Fuego. Finalmente, se analiza la relevancia de estos estudios para la interpretación del registro bioarqueológico.

  13. Plan de manejo sostenible de tierra para la producción de leche en la UBPC Aguadita, Cienfuegos, Cuba

    Directory of Open Access Journals (Sweden)

    Eligia de la C Cuellar

    Full Text Available Se realizó un estudio en la UBPC Aguadita, del municipio Rodas _provincia Cienfuegos, Cuba_, con el objetivo de elaborar un plan de manejo sostenible del suelo para incrementar la producción de leche. Se utilizó la guía contenida en el manual de procedimientos para la implementación del manejo sostenible de tierra. Los pasos de la guía permitieron concebir una investigación no experimental, de tipo correlacional/múltiple, en la que se utilizaron métodos teóricos y prácticos con sus correspondientes técnicas (entrevistas, encuestas, revisión documental, observación directa; y se realizaron mediciones en el lugar, con la aplicación de diez herramientas metodológicas. Se demostró que la baja producción de leche en la UBPC es causada fundamentalmente por la degradación de los suelos, la mala calidad de los pastos y la deficiente gestión del conocimiento, lo que coincide con la principal barrera para la aplicación del manejo sostenible de tierra. A partir de estos resultados se elaboró el plan de manejo sostenible, como herramienta que contribuye a desarrollar acciones que mitiguen el impacto negativo de la degradación de suelos en el rendimiento lechero de la unidad.

  14. Crecimiento ganadero y ocupación de tierras públicas, causas de conflictividad en la frontera bonaerense

    Directory of Open Access Journals (Sweden)

    Fernando Enrique Barba


    Full Text Available Sin dudas, la forma más visible de violencia practicada en la frontera de Buenos Aires durante los siglos XVIII y XIX fue la guerra entre el blanco y las diferentes parcialidades indígenas. Si bien puede afirmarse en sentido amplio que dicha guerra fue permanente, esta se intensificó en momentos determinados coincidentes con lo que podemos calificar, en rasgos generales, períodos de expansión ganadera. La presente colaboración intenta señalar entonces cuatro momentos en el proceso de expansión ganadera cuyas características generales fueron el aumento de los rebaños y ocupación de nuevas tierras, siendo estos hechos seguidos por la reacción de los indios quienes incrementaron los malones, pequeños en general y eventualmente masivos, en busca de los ganados de todo tipo existentes en las estancias bonaerenses. Los cuatro períodos a estudiar son: 1º a partir de las últimas vaquerías (1718; 2º la formación del virreinato y las nuevas condiciones de comercio; 3º la expansión ganadera a partir de 1810 y la ocupación de tierras más allá del Salado y 4º y el gran crecimiento a partir de Caseros

  15. Evaluación del efecto insecticida de tierra de diatomeas sobre Triatoma infestans (Hemíptera, Reduviidae

    Directory of Open Access Journals (Sweden)

    Mariana L Bilbao


    Full Text Available El Triatoma infestans es el principal vector de la enfermedad de Chagas en Argentina. La tierra de diatomeas (TD es un producto natural que se comercializa actualmente con fines insecticidas y que produce la muerte por deshidratación. Se evaluó la eficacia insecticida de TD al 60% de pureza, proveniente del yacimiento La Iglesiana (San Juan, Argentina sobre ninfas V y adultos de T.infestans. Se ensayaron dos dosis: 112,5 g/m2 (T1 y 225 g/m2 (T2, con cuatro réplicas por tratamiento, con cinco ejemplares, incluyendo los controles (TC en el laboratorio. Se contaron los individuos vivos y muertos durante cinco días. No se encontró diferencias en la mortalidad (ANOVA, p>0,05 en los adultos (T1: 40%, T2: 25% y TC: 30% ni en las ninfas V (T1: 10%, T2: 15% y TC: 10%. Se concluye que la tierra de diatomeas del yacimiento La Iglesiana, en las condiciones de laboratorio evaluadas, no posee capacidad insecticida sobre T.infestans.

  16. Cold- maritime processes in the Fuegian Mountains (Tierra del Fuego, Argentina) (United States)

    Pérez-Alberti, A.; Valcarcel-Diaz, M.; Castillo-Rodriguez, F.; Naya-Fernandez, S.; Carrera-Gomez, P.; Lopez-Bedoya, J.; Blanco-Chao, R.; Macias-Vazquez, F.


    Studies carried out since 2004 in the "Andes Fueguinos" (Tierra del Fuego, Argentina) demonstrate the great importance that cryogenic processes have at the present time. The current investigations are based on two directions of research: (1) the mapping of the existing cryonival forms, and (2) the measurement of their activity. First, the existing geomorphic forms have been identified and their positions located on a map by means of GPS; second, a number of ground control stations were established to provide environmental information for a variety of locations with differing conditions. In addition, grain size analysis of stones in different areas was undertaken to characterize the varying sediment characteristics. The first results demonstrate: 1. - The existence of numerous cryogenic geomorphic forms: sorted polygons and sorted stripes, rock glaciers, stratified slope deposits, solifluction lobes, and cryonival steps and debris flows. 2. - The importance of structural and lithological control on landforms and sediments. 3. - The presence of noticeable differences in the genesis and current dynamics of geomorphic forms due to topographic variables: orientation, slope and elevation. 4. - The importance of the role of the wind in the distribution of the snow and, consequently, in the degree of activity of the landforms. 5. - The role of the snow, as a factor of protection of the ground as well as a driving agent for the geomorphic processes. 6. - Differences in development between the presently active forms and those that have been produced in the recent past (which are now being colonized by vegetation). The installation of control stations to monitoring the temperature and moisture of ground and air has allowed us to know: 1. - The large variability in air temperatures (mean annual of - 3° C). 2. - The existence of marked differences in temperatures between the spring and the autumn with respect to the winter and the summer. 3. - The important role of frost heave

  17. Depth Seismic-Migration Modeling Offshore `Tierra Del Fuego', Argentina (54° 25' S) (United States)

    Comínguez, A. H.; Flores, J.; Tassone, A.


    Within the framework of the TESAC Project (Tectonic Evolution of the South America-Scotia plate boundary during the Cenozoic), about 900 km of multichannel seismic reflection profiles were acquired off the Atlantic coast of the Tierra del Fuego Island. The profiles cut across the South America-Scotia plate boundary, a transform margin which traverses in an E-W direction the Island. Data processing and interpretation of a seismic reflection profile is presented in this contribution. A robust post-stack technique involved depth-migration of the seismic section, using an interval-velocity model of the upper Crust adjusted by iterative processing. An interpreted seismic- velocity section (which trends roughly NW-SE), shows a complex superposition of different tectonic structures, with presence of extensional, compressional and transtensional features in the area located to the north of Isla de los Estados. The profile, which crosses the offshore part of the Magallanes fold-and-thrust belt, images the deep structural framework of part of this tectonic province. The identification of acoustic fabrics and seismic discontinuities allowed us to recognize four main units. Overlaying the acoustic basement (Seismic unit 1), there is another unit (Seismic unit 2) which exhibits some reflector packages of high amplitude; this unit must be related to the volcanic and volcaniclastic sequences of Tobífera/Lemaire Fms. The Seismic Unit 3 displays internal reflector configurations of moderate amplitude and continuity and low-to-moderate frequency; the Yaghán/Beauvoir Fms must be the onshore equivalent of this unit. An uppermost seismic layer (Unit 4) may be correlated with the Tertiary sediments of the Magallanes foreland basin which were involved in the fold and thrust belt. A major structure identified in the studied seismic profile is a SE structural high (which involves the units 1, 2 and 3) and a NW down-faulted area. The latter display folds of kilometric size (3-4 km

  18. Diversity of endosymbiotic Nostoc in Gunnera magellanica from Tierra del Fuego, Chile [corrected]. (United States)

    Fernández-Martínez, M A; de Los Ríos, A; Sancho, L G; Pérez-Ortega, S


    Global warming is causing ice retreat in glaciers worldwide, most visibly over the last few decades in some areas of the planet. One of the most affected areas is the region of Tierra del Fuego (southern South America). Vascular plant recolonisation of recently deglaciated areas in this region is initiated by Gunnera magellanica, which forms symbiotic associations with the cyanobacterial genus Nostoc, a trait that likely confers advantages in this colonisation process. This symbiotic association in the genus Gunnera is notable as it represents the only known symbiotic relationship between angiosperms and cyanobacteria. The aim of this work was to study the genetic diversity of the Nostoc symbionts in Gunnera at three different, nested scale levels: specimen, population and region. Three different genomic regions were examined in the study: a fragment of the small subunit ribosomal RNA gene (16S), the RuBisCO large subunit gene coupled with its promoter sequence and a chaperon-like protein (rbcLX) and the ribosomal internal transcribed spacer (ITS) region. The identity of Nostoc as the symbiont was confirmed in all the infected rhizome tissue analysed. Strains isolated in the present study were closely related to strains known to form symbioses with other organisms, such as lichen-forming fungi or bryophytes. We found 12 unique haplotypes in the 16S rRNA (small subunit) region analysis, 19 unique haplotypes in the ITS region analysis and 57 in the RuBisCO proteins region (rbcLX). No genetic variability was found among Nostoc symbionts within a single host plant while Nostoc populations among different host plants within a given sampling site revealed major differences. Noteworthy, interpopulation variation was also shown between recently deglaciated soils and more ancient ones, between eastern and western sites and between northern and southern slopes of Cordillera Darwin. The cell structure of the symbiotic relationship was observed with low-temperature scanning

  19. Role of matrix metalloproteinase‑7 and apoptosis‑associated gene expression levels in the pathogenesis of atrial fibrosis in a Beagle dog model. (United States)

    Jia, Min; Li, Zai-Bo; Li, Lin; Chu, Hong-Tao; Li, Zhuang-Zhuang


    The aim of the present study was to investigate the potential role of matrix metalloproteinase‑7 (MMP‑7) and apoptosis‑associated genes [TIMP metallopeptidase inhibitor 2(TIMP‑2), BCL2 associated X, apoptosis regulator (BAX) and BCL2, apoptosis regulator (BCL‑2)] in the pathogenesis of atrial fibrillation (AF) in a Beagle dog model. A total of 20 adult male Beagle dogs were randomly assigned into the AF group (n=10; Beagle dogs were treated by Burst stimulation to induce AF) and the control group (n=10; healthy Beagle dogs). Echocardiography and Mallory staining were used to determine cardiac function and degree of atrial fibrosis, respectively. Reverse transcription‑quantitative polymerase chain reaction and western blotting were performed to determine collagen type 1 (Col I), MMP‑7, TIMP‑2, BAX and BCL‑2 mRNA and protein expression levels. Compared with the control group, the AF group presented increased degree of atrial fibrosis and level of Col I expression, elevated MMP‑7 and BAX expression levels, but decreased TIMP‑2 and BCL‑2 expression levels. Correlation analysis demonstrated that MMP‑7 and BAX protein expression levels were negatively correlated with left ventricular ejection fraction (LVEF), but positively correlated with the degree of atrial fibrosis. Negative correlation was observed between TIMP‑2 and BCL‑2 protein expression levels and degree of atrial fibrosis. In addition, a positive correlation between TIMP‑2 and BCL‑2 protein expression levels and LEVF was observed. These results demonstrate that MMP‑7 and BAX were highly expressed, while TIMP‑2 and BCL‑2 were downregulated in a Beagle dog model of AF, indicating that MMP‑7 and apoptosis‑associated genes (TIMP‑2, BAX and BCL‑2) may be associated with the pathogenesis of AF.

  20. The effect of interleukin-11 on the progression of ligature-induced periodontal disease in the beagle dog. (United States)

    Martuscelli, G; Fiorellini, J P; Crohin, C C; Howell, T H


    The rate of progression of periodontal disease is dependent on the complex regulatory interactions between bacteria and the immune modulators of the host response. The purpose of this investigation was to determine if recombinant human interleukin-11 (rhIL-11), known to downregulate several inflammatory modulators, has the ability in subcutaneous administration to reduce the rate and/or extent of periodontal attachment loss and radiographic bone loss in a ligature-induced periodontal disease beagle dog model. Twenty 18-month-old female beagle dogs were brought to optimal periodontal health over a 2-week period. Periodontal disease was induced by placing 2.0 silk ligatures around the mandibular first molar and premolar teeth. The dogs were divided into 3 treatment groups and one control group. The 3 treatment groups received subcutaneous injections of either 15, 30, or 80 microg/kg of rhIL-11 in saline buffer twice a week. The placebo group received buffer only subcutaneously twice a week. The gingival health of each animal was measured by recording the presence or absence of gingival inflammation, plaque, and bleeding upon probing. Attachment levels and bone height were also measured. Treatment administration and clinical and radiographic evaluations were performed in a masked fashion. At week 8, the placebo group had 3.89 mm of attachment loss and 73.8% radiographic bone remaining. The 15 microg/kg group had 1.99 mm attachment loss and 89.5% bone remaining; the 30 microg/kg group had 0.84 mm attachment loss and 92.5% bone remaining; and the 80 microg/kg group had 1.05 mm attachment loss and 85.5% bone remaining. All 3 treatment groups lost significantly less attachment and retained significantly more bone than did the placebo group. The study indicates that subcutaneous injections of rhIL-11 were able to slow the progression of attachment and radiographic alveolar bone loss in a ligature-induced beagle dog model.

  1. Superior Canal Dehiscence Syndrome Affecting 3 Families. (United States)

    Heidenreich, Katherine D; Kileny, Paul R; Ahmed, Sameer; El-Kashlan, Hussam K; Melendez, Tori L; Basura, Gregory J; Lesperance, Marci M


    Superior canal dehiscence syndrome (SCDS) is an increasingly recognized cause of hearing loss and vestibular symptoms, but the etiology of this condition remains unknown. To describe 7 cases of SCDS across 3 families. This retrospective case series included 7 patients from 3 different families treated at a neurotology clinic at a tertiary academic medical center from 2010 to 2014. Patients were referred by other otolaryngologists or were self-referred. Each patient demonstrated unilateral or bilateral SCDS or near dehiscence. Clinical evaluation involved body mass index calculation, audiometry, cervical vestibular evoked myogenic potential testing, electrocochleography, and multiplanar computed tomographic (CT) scan of the temporal bones. Zygosity testing was performed on twin siblings. The diagnosis of SCDS was made if bone was absent over the superior semicircular canal on 2 consecutive CT images, in addition to 1 physiologic sign consistent with labyrinthine dehiscence. Near dehiscence was defined as absent bone on only 1 CT image but with symptoms and at least 1 physiologic sign of labyrinthine dehiscence. A total of 7 patients (5 female and 2 male; age range, 8-49 years) from 3 families underwent evaluation. Family A consisted of 3 adult first-degree relatives, of whom 2 were diagnosed with SCDS and 1 with near dehiscence. Family B included a mother and her child, both of whom were diagnosed with unilateral SCDS. Family C consisted of adult monozygotic twins, each of whom was diagnosed with unilateral SCDS. For all cases, dehiscence was located at the arcuate eminence. Obesity alone did not explain the occurrence of SCDS because 5 of the 7 cases had a body mass index (calculated as weight in kilograms divided by height in meters squared) less than 30.0. Superior canal dehiscence syndrome is a rare, often unrecognized condition. This report of 3 multiplex families with SCDS provides evidence in support of a potential genetic contribution to the etiology

  2. [The effect of left bacteria in the root canal on prognosis of the root canal therapy]. (United States)

    He, Jin-mei; Bian, Zhuan; Fan, Ming-wen; Fan, Bing


    To study the effect of the left bacteria on the root canal therapy. 50 single-rooted teeth with chronic apical periodontitis were divided into two groups, one was instrumented with step-back technique and 2.5%NaOCl ultrasonic irrigation for 3 min, then filled with Thermafil. Samples were taken after instrumentation to culture. The other was treated with traditional RCT at three visits. In 24 months the apical radiolucency were greatly reduced in all cases. There weren't significant relationship among the postoperative pain and the left bacteria, the degree of the obturation or the pre-operative symptoms (P > 0.05). The effect of left bacteria in root canal filled with Thermafil wasn't observed.

  3. Modelo para evaluar la calidad de las tierras: caso del cultivo de papa

    Directory of Open Access Journals (Sweden)

    Martínez Luis Joel


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    Dentro de la busqueda de la sostenibilidad y la competitividad de la agricultura, la evaluacion de la calidad de las tierras es un aspecto basico que permite tomar decisiones sobre  las areas mas apropiadas para ubicar los cultivos y sobre los procesos de degradación de las tierras, con el fin de tomar medidas para su manejo y conservacion. En esta investigacion se

  4. Checklist of the Discomycetes (Fungi of Patagonia, Tierra del Fuego and adjacent antarctic areas

    Directory of Open Access Journals (Sweden)

    Irma J. Gamundí


    Full Text Available La información brindada en este catálogo consiste en registrar las especies de hongos pertenecientes a los órdenes Cyttariales, Helotiales, Ostropales, Pezizales, Rhytismatales y Thelebolales (Discomycetes coleccionadas en Patagonia, Tierra del Fuego y áreas adyacentes antárticas (Patagonia. Además datos sobre sus organismos asociados fueron localizados, resumidos, validados y editados. Las fuentes de información fueron las exsiccatae depositadas en colecciones de Argentina y otros países y de las publicaciones listadas en la bibliografía. Otros registros derivaron de observaciones de campo sobre material fresco y colecciones de referencia. La información fue acumulada en un sistema computarizado relacional de datos taxonómicos, nomenclaturales, bibliográficos, de distribución geográfica y de observaciones biológicas. Este sistema permite la acumulación de datos paralelos en diferentes idiomas, y distingue la información original de la opinión corriente de lo que puede significar esa información. En la Biological Records Database, 5029 registros fueron creados para observaciones sobre la ocurrencia temporal y espacial de los organismos vivos de la región. De éstos, 2613 corresponden a registros de colecciones de Discomycetes de la Patagonia y Tierra del Fuego, con la siguiente distribución: 1854 para a la Argentina, 687 para Chile y 72 para áreas adyacentes antárticas. Excluyendo los sinónimos, los Discomycetes están representados por 361 especies y taxones subespecíficos (160 géneros, 22 familias y 7 órdenes. Los registros remanentes fueron de organismos asociados con los Discomycetes: 163 animales (8 especies, 8 géneros, 6 familias y 5 órdenes; 2 Chromista; 223 hongos (52 especies, 54 géneros, 26 familias y 13 ódenes; 2028 plantas (159 especies, 122 géneros, 59 familias y 39 órdenes. Cada uno de estos taxones (y cada sinónimo conocido está representado por un registro separado en la Base de Datos Taxon

  5. The effects of repeated intravenous iohexol administration on renal function in healthy beagles – a preliminary report

    Directory of Open Access Journals (Sweden)

    Kirberger Robert M


    Full Text Available Abstract Background Contrast induced nephrotoxicity (CIN is a well described syndrome in humans undergoing contrast medium examinations. To date CIN has received minimal attention in the veterinary literature despite increasing use of contrast medium examinations in computed tomographic studies. Methods This prospective study evaluated the effect of 1290 mg/kg iohexol given intravenously to 5 normal beagle dogs in a divided dose at an interval of 6–8 weeks. Renal function was evaluated by means of scintigraphically determined glomerular filtration rate (GFR and a variety of laboratory assays. Results Only GFR showed a significant decrease (17% after the second injection but not to a clinically or pathologically significant level. Conclusions No clinically significant effect of repeated contrast medium administration was determined in this limited study. However in dogs with reduced renal function the risk of CIN is likely to increase dramatically post contrast administration.

  6. Placebo-controlled double-blind clomipramine trial for the treatment of anxiety or fear in beagles during ground transport. (United States)

    Frank, Diane; Gauthier, Audrey; Bergeron, Renée


    The purpose of this explorative study was, first, to document changes in physiological parameters and behavior observed in dogs following ground transport and, second, to measure the effects on the above variables of a short-term administration of clomipramine, anecdotally already prescribed in private veterinary practice to reduce fear, anxiety, or both. Twenty-four beagles were randomly allocated to either clomipramine (2 mg/kg, q12h for 7 d) or placebo treatment, and then transported 3 times in a truck for 1 hour. Physiological parameters (cortisol, neutrophil:lymphocyte (N:L) ratio, heart rate) and behavior were recorded and analyzed. Clomipramine significantly reduced plasma cortisol (P anxiety, or both during transport. More research is needed to confirm the efficacy of this treatment and the appropriate dosage.

  7. Effect of biphasic calcium phosphate nanocomposite on healing of surgically created alveolar bone defects in beagle dogs (United States)

    Wang, Lanlei; Guan, Aizhong; Shi, Han; Chen, Yangxi; Liao, Yunmao


    The aim of the present study was to investigate the effect of porous biphasic calcium phosphate nanocomposite (nanoBCP) scaffolds bioceramic. Alveolar bone defects were surgically created bilaterally at the buccal aspects of the upper second premolar in fourteen beagle dogs. After root conditioning with ethylenediaminetetraacetate (EDTA), nanoBCP was randomly filled in the defects and nothing was put into the contralaterals as controls. Dogs were killed at the 12th weeks. Histological observations were processed through a light microscopy. The results revealed that a great amount of functional periodontal fissures formed in the defects in the nanoBCP groups while minimal bone took shape in the controls. In this study, nanoBCP has proved to work well as a biocompatible and osteoconductive scaffold material to promote periodontal regeneration effectively.

  8. Hematological responses after inhaling {sup 238}PuO{sub 2}: An extrapolation from beagle dogs to humans

    Energy Technology Data Exchange (ETDEWEB)

    Scott, B.R.; Muggenburg, B.A.; Welsh, C.A.; Angerstein, D.A.


    The alpha emitter plutonium-238 ({sup 238}Pu), which is produced in uranium-fueled, light-water reactors, is used as a thermoelectric power source for space applications. Inhalation of a mixed oxide form of Pu is the most likely mode of exposure of workers and the general public. Occupational exposures to {sup 238}PuO{sub 2} have occurred in association with the fabrication of radioisotope thermoelectric generators. Organs and tissue at risk for deterministic and stochastic effects of {sup 238}Pu-alpha irradiation include the lung, liver, skeleton, and lymphatic tissue. Little has been reported about the effects of inhaled {sup 238}PuO{sub 2} on peripheral blood cell counts in humans. The purpose of this study was to investigate hematological responses after a single inhalation exposure of Beagle dogs to alpha-emitting {sup 238}PuO{sub 2} particles and to extrapolate results to humans.

  9. Ectopic thyroid tissue in the periaortic area, cardiac cavity and aortic valve in a Beagle dog - a case report. (United States)

    Roth, Daniel Robert; Perentes, Elias


    Microscopic examination of the heart of a clinically normal 14-month-old female Beagle dog revealed the presence of ectopic thyroid tissue at the base of the heart, around the aorta, and intracardially at the level of the left ventricle and the aortic valve. The tissue was composed of well-differentiated follicles lined by a cuboidal epithelium and containing colloid. Follicular cells and colloid exhibited strong thyroglobulin immunoreactivity, while no parafollicular cells were noted and the immunoreactions for calcitonin remained consistently negative. Although in the dog ectopic thyroid tumors represent 1-10% of all heart base neoplasms (Capen, 1978; Bracha et al., 2009), to the best of our knowledge, nonneoplastic ectopic thyroid tissue has not been reported in the heart of the dog itself or within the dog aortic valve. Copyright © 2010 Elsevier GmbH. All rights reserved.

  10. "My appointment received the sanction of the Admiralty": why Charles Darwin really was the naturalist on HMS Beagle. (United States)

    van Wyhe, John


    For decades historians of science and science writers in general have maintained that Charles Darwin was not the 'naturalist' or 'official naturalist' during the 1831-1836 surveying voyage of HMS Beagle but instead Captain Robert FitzRoy's 'companion', 'gentleman companion' or 'dining companion'. That is, Darwin was primarily the captain's social companion and only secondarily and unofficially naturalist. Instead, it is usually maintained, the ship's surgeon Robert McCormick was the official naturalist because this was the default or official practice at the time. Although these views have been repeated in countless accounts of Darwin's life, this essay aims to show that they are incorrect. Copyright © 2013 Elsevier Ltd. All rights reserved.

  11. Closing a chapter on Love Canal

    Energy Technology Data Exchange (ETDEWEB)


    The toxic wastes that were dumped in the 1950s at Love Canal in New York and then seeped into groundwater and the basements of local residents in the late 1970s are to be finally incinerated, according to a plan recently announced by the US Environmental Protection Agency (EPA). This last, five-year stage in the cleanup will entail the building of an incinerator for burning 35,000 cubic yards of dioxin-contaminated sediment dredged from creeks and sewers in the area at a cost of up to $31 million. The incinerated residue - which will be purified of detectable levels of dioxin, says EPA - will be returned to the site and spread several feet deep.

  12. 8. Le TGV et le canal


    Fortier, Agnès


    7. Le TGV près du Creusot Une double rame du tgv Sud-Est se dirige vers Paris. Elle vient de franchir le viaduc du canal du Centre qui longe l’un de ses réservoirs d’alimentation, l’étang de Longpendu, visible sur la droite. Elle croise la voie « plm » dont on note le discret ballast en avant de l’étang. Plusieurs lignes à très haute tension partent d’un important équipement de répartition tout proche. L’une d’elles sert notamment à l’alimentation du tgv. La photographie est prise d’un des ra...

  13. Seismically observed seiching in the Panama Canal (United States)

    McNamara, D.E.; Ringler, A.T.; Hutt, C.R.; Gee, L.S.


    A large portion of the seismic noise spectrum is dominated by water wave energy coupled into the solid Earth. Distinct mechanisms of water wave induced ground motions are distinguished by their spectral content. For example, cultural noise is generally Panama Canal there is an additional source of long-period noise generated by standing water waves, seiches, induced by disturbances such as passing ships and wind pressure. We compare seismic waveforms to water level records and relate these observations to changes in local tilt and gravity due to an oscillating seiche. The methods and observations discussed in this paper provide a first step toward quantifying the impact of water inundation as recorded by seismometers. This type of quantified understanding of water inundation will help in future estimates of similar phenomena such as the seismic observations of tsunami impact. Copyright 2011 by the American Geophysical Union.


    Directory of Open Access Journals (Sweden)

    Mukhergee G. S


    Full Text Available BACKGROUND Spinal stenosis is one of the most common conditions in the elderly. It is defined as a narrowing of the spinal canal. The term stenosis is derived from the Greek word for narrow, which is “Stenos”. The first description of this condition is attributed to Antoine portal in 1803. Verbiest is credited with coining the term spinal stenosis and the associated narrowing of the spinal canal as its potential cause. [1-10] Kirkaldy–Willis subsequently described the degenerative cascade in the lumbar spine as the cause for the altered anatomy and pathophysiology in spinal stenosis. [11-15] If compression does not occur, the canal should be described as narrow but not stenotic. Some studies defined lumbar spinal stenosis as a “narrowing of the osteoligamentous vertebral canal and/or the intervertebral foramina causing compression of the thecal sac and/or the caudal nerve roots; at a single vertebral level, narrowing may affect the whole canal or part of it” (Postacchini 1983. This definition distinguished between disc herniation and stenosis. [16] . The most common type of spinal stenosis is caused by degenerative arthritis of the spine. Hypertrophy and ossification of the posterior longitudinal ligament which usually are confined to the cervical spine, and diffuse idiopathic skeletal hyperostosis (DISH syndrome also may result in an acquired form of spinal stenosis. Congenital forms caused by disorders such as achondroplasia and dysplastic spondylolisthesis are much less common. Congenital spinal stenosis usually is central and is evident or imaging studies. Idiopathic congenital narrowing usually involves the anteroposterior dimension of the canal secondary to short pedicles; the patient otherwise is normal. In contrast, in achondroplasia, the canal is narrowed in the anteroposterior plane owing to shortened pedicles and in lateral dimension because of diminished interpedicular distance. Acquired forms of spinal stenosis usually are

  15. [Latest treatment of lumbar canal stenosis]. (United States)

    Kim, Kyongsong; Isu, Toyohiko


    Lumbar canal stenosis (LCS) is a degenerative disease involving the lumbar vertebrae, discs, and ligamentum flavum that result in neurological deficit to some extent. The natural history of symptoms of LCS is highly important because they do not necessarily worsen with progressive degeneration. Therefore, a observation therapy is adopted for the treatment of this condition. Although invasive treatment is required for some patients, surgery cannot be performed solely on the basis of radiological findings and careful evaluation of neurological symptoms is necessary. In the event that spinal surgery is required, it is important to minimize degree of invasiveness; various devices and operative approaches and methods have been developed to this end. Our strategy for the surgical treatment of LCS involves microscopic decompression via a posterior approach. In our method, modified bilateral decompression via the splitting of the spinous process using an ultrasonic bone curette (SONOPET), and the results of this approach have been excellent. Our method is less invasive, facilitates the preservation of the paraspinal muscle, and represents a useful approach to posterior spinal elements. Our findings indicate that this method involves less muscle damage as compared to other methods. LCS should be differentiated from conditions other than those involving the spinal canal such as foraminal stenosis and far-out syndrome, piriformis syndrome, and tarsal tunnel syndrome. The incidence of these conditions is higher than appreciated and they present with neurological deficits similar to observed in LCS. Here, we report our criteria of operative indications for surger and the procedures that we developed for the treatment of LCS, based on a review of the available literature.

  16. Novel phenotype in beagle dogs characterized by skin response to compound 48/80 focusing on skin mast cell degranulation (United States)

    Uchida, Mitsuhiro; Ito, Fumi; Tsuchiya, Toshiyuki; Shoji, Yoko; Kurosawa, Toru


    Beagle dogs have long been employed in toxicology studies and as skin disease models. Compared with other experimental animal species, they are known to be susceptible to skin responses, such as rashes, from exposure to various chemical compounds. Here, a unique dog phenotype was identified that showed no skin response to compound 48/80, a mast cell degranulating agent. Although the skin responses to intradermal injection of polyoxyethylene castor oil derivative (HCO-60, a nonionic detergent), histamine dihydrochloride, concanavalin A (IgE receptor-mediated stimuli), or calcium ionophore A23187 were comparable in wild-type (WT) dogs and these nonresponder (NR) dogs, only the response to compound 48/80 was entirely absent from NR dogs. The skin mast cell density and histamine content per mast cell were histologically comparable between WT and NR dogs. By checking for skin responses to compound 48/80, NR dogs were found to exist at the proportion of 17–20% among four animal breeders. From retrospective analysis of in-house breeding histories, the NR phenotype appears to conform to the Mendelian pattern of recessive inheritance. The standard skin response in WT dogs developed at 2–4 months of age. In conclusion, this unique phenotype, typified by insensitivity in the compound 48/80-induced degranulation pathway in mast cells, has been widely retained by recessive inheritance in beagle dogs among general experimental animal breeders. The knowledge concerning this phenotype could lead to better utilization of dogs in studies and aid in model development. PMID:26062768

  17. How do rehomed laboratory beagles behave in everyday situations? Results from an observational test and a survey of new owners (United States)

    Nick, Ophelia; Bauer, Alexander; Küchenhoff, Helmut; Erhard, Michael H.


    When laboratory dogs are rehomed into private households, they experience an extreme change in their life situation. They leave their familiar, limited environment in the research facility and encounter a multitude of animate and inanimate stimuli in their new home. Although literature reports have described the experiences with rehoming as being mostly positive, scientific observations of the dogs in everyday situations have not been done. Hence, we conducted an observational test with 74 laboratory beagles 6 weeks after adoption in their new homes. This test included standardized tasks and elements; the dogs were observed during specific interactions with their new owners and during a walk. Furthermore, the owners of these 74 and of 71 additional dogs participated in standardized phone interviews 1 and 12 weeks after adoption, during which they answered questions about the dogs’ behavior in everyday situations. In the observational test, the dogs behaved mostly friendly towards humans and dogs, were tolerant during manipulations by the owner and were relaxed during the walk, even in traffic. Eighty percent (of n = 71) of the dogs walked well behaved on the leash without pulling. According to the interviews, the majority of the dogs showed desired, friendly and relaxed behavior, and the survey results reflected the bonding between dog and owner. The analysis of a possible influence of various factors (age, sex, origin, etc.) using mixed regression models confirmed the results from two previous behavior tests and interviews. Specifically, dogs that had been bred in the research facility scored significantly better than dogs that the research facility had purchased from commercial laboratory dog breeders (p = 0.0113). The results of this study demonstrate a successful adaptation of the rehomed beagles to their new life situation. PMID:28742824

  18. Anatomical and ultrasonographic study of the femoral nerve within the iliopsoas muscle in beagle dogs and cats. (United States)

    Mogicato, Giovanni; Layssol-Lamour, Catherine; Mahler, Stephan; Charrouin, Maxime; Boyer, Guillaume; Verwaerde, Patrick; Jourdan, Géraldine


    An ultrasound (US)-guided ventral suprainguinal approach to block the femoral nerve (FN) within the iliopsoas muscle (IPM) has recently been described in dogs. The goal of the present study was to provide the operator with additional information to locate the FN within the IPM in dogs and cats using US. The study was carried out in three phases: a dissection of the FN (phase 1); an in vivo US-assisted nerve study (phase 2), and an anatomical cross-sectional study (phase 3). Nine healthy adult beagle dogs and nine healthy adult cats. Dissections were performed to investigate the anatomical characteristics of the FN and its related structures in one dog and one cat. Ultrasound scans of the left and right FN were performed in eight dogs and eight cats. The FN diameter and the distance between the FN and the external iliac artery (EIA) in US images and in anatomical cryosections were measured. The median FN diameter did not differ significantly between cats and dogs (1.1 mm versus 1.0 mm) or between the two techniques (US versus anatomical cross-sectional study) (1.1 mm versus 1.1 mm in dogs; 1.0 mm versus 1.1 mm in cats). The US and anatomical measurements of the median distances between the FN and EIA differed significantly between dogs and cats (8.2 mm versus 5.8 mm by US; 5.7 mm versus 4.8 mm in the anatomical study). The distance between the EIA and FN is reproducible in beagle dogs and cats and can be used in locating the FN within the IPM. © 2015 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.

  19. Application of collagen hydrogel/sponge scaffold facilitates periodontal wound healing in class II furcation defects in beagle dogs. (United States)

    Kosen, Y; Miyaji, H; Kato, A; Sugaya, T; Kawanami, M


    A three-dimensional scaffold may play an important role in periodontal tissue engineering. We prepared bio-safe collagen hydrogel, which exhibits properties similar to those of native extracellular matrix. The aim of this study was to examine the effect of implantation of collagen hydrogel/sponge scaffold on periodontal wound healing in class II furcation defects in dogs. The collagen hydrogel/sponge scaffold was prepared by injecting collagen hydrogel, cross-linked to the ascorbate-copper ion system, into a collagen sponge. Class II furcation defects (of 5 mm depth and 3 mm width) were surgically created in beagle dogs. The exposed root surface was planed and demineralized with EDTA. In the experimental group, the defect was filled with collagen hydrogel/sponge scaffold. In the control group, no implantation was performed. Histometric parameters were evaluated 2 and 4 wk after surgery. At 2 wk, the collagen hydrogel/sponge scaffold displayed high biocompatibility and biodegradability with numerous cells infiltrating the scaffold. In the experimental group, reconstruction of alveolar bone and cementum was frequently observed 4 wk after surgery. Periodontal ligament tissue was also re-established between alveolar bone and cementum. Volumes of new bone, new cementum and new periodontal ligament were significantly greater in the experimental group than in the control group. In addition, epithelial down-growth was suppressed by application of collagen hydrogel. The collagen hydrogel/sponge scaffold possessed high tissue compatibility and degradability. Implantation of the scaffold facilitated periodontal wound healing in class II furcation defects in beagle dogs. © 2012 John Wiley & Sons A/S.


    National Research Council Canada - National Science Library



    ... la contaminación por el aceite dieléctrico presente en la tierra Fuller, Buscando con ello gestionar de forma ambientalmente adecuada este residuo peligroso. Para la Tecnología físico-química, se usó...