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Sample records for canal beagle tierra

  1. Facies del subfondo del canal Beagle, Tierra del Fuego

    Directory of Open Access Journals (Sweden)

    Gustavo Bujalesky

    2004-03-01

    Full Text Available El canal Beagle conecta los océanos Pacífico y Atlántico en el extremo meridional de Sudamérica y se ubica en el ambiente subantártico. Conforma una cuenca de unos 300 m de profundidad máxima y está separada del océano Atlántico por un umbral de 30 m de profundidad. El canal es un valle tectónico que fue completamente cubierto por el hielo glacial durante la última glaciación. Posteriormente, el canal fue ocupado por un lago glacial desde los 12.000 a los 8.000 años A.P., cuando fue invadido por el mar que alcanzó un nivel máximo entre los 6.000 y 5.000 años A.P. Con el objetivo de analizar las facies sedimentarias superficiales y del subfondo del canal se realizó un relevamiento geofísico con sonar de barrido lateral y un perfilador de 3,5 kHz. Sobre un basamento constituido por rocas metamórficas del Mesozoico, se identificaron depósitos de till y secuencias granodecrecientes que representan distintos estadios del retroceso glaciar, evidenciando hacia la sección superior facies lacustres y por encima depósitos de la transgresión marina del Holoceno. Además, se han identificado paleocauces y secuencias fluviales cubiertas por sedimentos marinos transgresivos.

  2. Mischiuen III, un contexto funerario singular en el Canal Beagle (Tierra del Fuego)

    OpenAIRE

    Vila-Mitjà, Assumpció; Casas, Alicia; Oriol Vicente, Campos

    2006-01-01

    (ESP)Presentamos aquí los trabajos realizados en un contexto funerario singular, Mischiuen III, así como los primeros resultados obtenidos. Este estudio aporta nuevos datos para la comprensión de las sociedades cazadoras- recolectoras de Tierra del Fuego, y se enmarca en los proyectos de investigación etnoarqueológica que venimos desarrollando en la costa argentina del canal Beagle desde finales de los años 80. Al mismo tiempo se presentan los resultados de la aplicación de nuevas metodología...

  3. Facies del subfondo del canal Beagle, Tierra del Fuego Sub-bottom facies of the Beagle Channel, Tierra del Fuego

    Directory of Open Access Journals (Sweden)

    Gustavo Bujalesky

    2004-03-01

    Full Text Available El canal Beagle conecta los océanos Pacífico y Atlántico en el extremo meridional de Sudamérica y se ubica en el ambiente subantártico. Conforma una cuenca de unos 300 m de profundidad máxima y está separada del océano Atlántico por un umbral de 30 m de profundidad. El canal es un valle tectónico que fue completamente cubierto por el hielo glacial durante la última glaciación. Posteriormente, el canal fue ocupado por un lago glacial desde los 12.000 a los 8.000 años A.P., cuando fue invadido por el mar que alcanzó un nivel máximo entre los 6.000 y 5.000 años A.P. Con el objetivo de analizar las facies sedimentarias superficiales y del subfondo del canal se realizó un relevamiento geofísico con sonar de barrido lateral y un perfilador de 3,5 kHz. Sobre un basamento constituido por rocas metamórficas del Mesozoico, se identificaron depósitos de till y secuencias granodecrecientes que representan distintos estadios del retroceso glaciar, evidenciando hacia la sección superior facies lacustres y por encima depósitos de la transgresión marina del Holoceno. Además, se han identificado paleocauces y secuencias fluviales cubiertas por sedimentos marinos transgresivos.The Beagle Channel connects the Pacific and Atlantic oceans in the southernmost part of South America, and has a subantarctic environment. It is a deep basin (300 m depth separated from the Atlantic Ocean by a shallow sill (30 m depth. The Beagle Channel is a tectonic valley that was completely covered by ice during the Last Glaciation. Later, it was occupied by a glacial lake from 12,000 to 8,000 years B.P. and then flooded by the sea, reaching a maximum sea level between 6,000 and 5,000 years B.P. A geophysical survey (side scan sonar and 3.5 kHz profiler was carried out in the channel to analyze the sea-bed and sub-bottom sedimentary facies. Metamorphic Mesozoic basement rocks are overlain by glacial deposits (till and fining upwards sequences. These sequences

  4. Distribución batimétrica, espacial y temporal del macrozoobentos en el Canal Beagle, Tierra del Fuego, Argentina

    OpenAIRE

    Diez, M.

    2006-01-01

    El Canal Beagle (Tierra del Fuego, Argentina) se encuentra en el sistema de canales fueguinos que representa el ambiente marino subantártico costero más estrechamente relacionado con la Antártida. Además, el Canal Beagle constituye una vía de intercambio de fauna y flora ente los océanos Pacífico y Atlántico. El objetivo de este trabajo fue determinar la composición, abundancia y biomasa del macrozoobentos en el Canal Beagle como también la producción secundaria de los ensambles bentónicos. D...

  5. Artes y métodos de pesca desarrollados en el Canal de Beagle, Tierra del Fuego, Argentina.

    OpenAIRE

    Izzo, A.; Isla, M.; Salvini, L; Bartozzetti, J.D.; Garcia, J.C. (Juan); Roth, R.R.; Prado, L.; Ercoli, R.

    2000-01-01

    This paper deals with the design and application of different fishing gears tested in the Beagle Channel (Tierra del Fuego, Argentina) with the supervision of the technical personnel of INIDEP Fishing Gear Group, the support of the General Directorate of Natural Resources (known today as SRNyAH) of Tierra del Fuego, Antártida e Islas del Atlántico Sur Province and the participation of local fishermen. Activities started as a result of an agreement between the INIDEP and the SRNyAH ratified i...

  6. Isótopos estables del carbono en restos humanos de Península Mitre y del Canal Beagle, Tierra del Fuego

    OpenAIRE

    Kozameh, Livia Febes; Panarello, Héctor; Tessone, Augusto; Testa, N; Valencio, Susana; Zangrando, Francisco Atilio

    2003-01-01

    El objetivo de este trabajo es realizar un análisis comparativo de los valores isotópicos del carbono (δ13C) medidos sobre gelatina ósea extraída de restos humanos procedentes de Península Mitre y del canal Beagle, Tierra del Fuego. Paralelamente, se discute esta información con aquella recabada a partir de otros estudios referidos a rastros fisiológicos y patológicos del esqueleto y del aparato masticatorio efectuados en ambas regiones. Los resultados señalan que, si bien en los análisis de ...

  7. Isótopos estables del carbono en restos humanos de Península Mitre y del Canal Beagle, Tierra del Fuego

    Directory of Open Access Journals (Sweden)

    Kozameh, Livia Febes

    2003-01-01

    Full Text Available El objetivo de este trabajo es realizar un análisis comparativo de los valores isotópicos del carbono (δ13C medidos sobre gelatina ósea extraída de restos humanos procedentes de Península Mitre y del canal Beagle, Tierra del Fuego. Paralelamente, se discute esta información con aquella recabada a partir de otros estudios referidos a rastros fisiológicos y patológicos del esqueleto y del aparato masticatorio efectuados en ambas regiones. Los resultados señalan que, si bien en los análisis de rastros se encuentran ciertas diferencias, los valores isotópicos obtenidos dan cuenta de dietas análogas basadas predominantemente en la explotación de recursos marinos.

  8. Isótopos estables del carbono en restos óseos humanos de la región del canal Beagle, Isla Grande de Tierra del Fuego

    OpenAIRE

    Tessone, Augusto; Zangrando, Francisco Atilio; Valencio, Susana; Panarello, Héctor

    2003-01-01

    El objetivo de este trabajo es conocer las particularidades de la dieta de grupos cazadores-recolectores, que habitaron la región del canal Beagle durante el Holoceno medio y tardío, mediante el análisis de isótopos estables del carbono sobre el colágeno de sus restos óseos. Se dan a conocer los valores de la 8¹³C obtenidos en cinco individuos. Seis determinaciones efectuadas previamente por otros autores en la misma región señalaron una variación mayor que la esperada en base a la informació...

  9. Paleoambientes litorales durante el inicio de la trasgresión marina holocena en bahía Lapataia, canal Beagle, parque nacional Tierra del Fuego

    Directory of Open Access Journals (Sweden)

    Jorge Rabassa

    2009-12-01

    Full Text Available Los sitios Aserradero Lapataia 1 y 2 presentan depósitos limo-arcillosos portadores de valvas de moluscos: Mulinia edulis, Mytilus chilensis, Aulacomya atra y Yoldia sp. Además predominan los quistes de dinoflagelados, revestimientos de foraminíferos bentónicos y huevos de copépodos. Valvas de Mulinia edulis fueron datadas radiocarbónicamente en 8.094 ± 43 (AA74047 y 8.167 ± 43 (AA74048 a A.P. En Arroyo Baliza depósitos limo-arcillosos son portadores de Venus antiqua, Aulacomya atra, Mytilus chilensis, entre otros. La microflora está dominada por dinoquistes protoperidinioideos, acritarcos y restos de copépodos. Se sugiere ambientes marino-marginales, con baja a moderada salinidad, y altas concentraciones de nutrientes en las aguas superficiales. La datación radiocarbónica sobre Venus antiqua en Arroyo Baliza indica 2.844 ± 34 a A.P. (AA74046. Aserradero Lapataia confirma las edades más antiguas conocidas para la fase estuárica de la transgresión holocena en el canal Beagle. Arroyo Baliza aporta nueva evidencia de la fase regresiva en este canal durante el Holoceno tardío.

  10. Paleoambientes litorales durante el inicio de la trasgresión marina holocena en bahía Lapataia, canal Beagle, parque nacional Tierra del Fuego Littoral paleoenvironments during the beginning of the Holocene marine transgression in Lapataia Bay, Beagle Channel, National Park of Tierra del Fuego

    Directory of Open Access Journals (Sweden)

    Jorge Rabassa

    2009-12-01

    Full Text Available Los sitios Aserradero Lapataia 1 y 2 presentan depósitos limo-arcillosos portadores de valvas de moluscos: Mulinia edulis, Mytilus chilensis, Aulacomya atra y Yoldia sp. Además predominan los quistes de dinoflagelados, revestimientos de foraminíferos bentónicos y huevos de copépodos. Valvas de Mulinia edulis fueron datadas radiocarbónicamente en 8.094 ± 43 (AA74047 y 8.167 ± 43 (AA74048 a A.P. En Arroyo Baliza depósitos limo-arcillosos son portadores de Venus antiqua, Aulacomya atra, Mytilus chilensis, entre otros. La microflora está dominada por dinoquistes protoperidinioideos, acritarcos y restos de copépodos. Se sugiere ambientes marino-marginales, con baja a moderada salinidad, y altas concentraciones de nutrientes en las aguas superficiales. La datación radiocarbónica sobre Venus antiqua en Arroyo Baliza indica 2.844 ± 34 a A.P. (AA74046. Aserradero Lapataia confirma las edades más antiguas conocidas para la fase estuárica de la transgresión holocena en el canal Beagle. Arroyo Baliza aporta nueva evidencia de la fase regresiva en este canal durante el Holoceno tardío.The Aserradero Lapataia 1 and 2 sites present clayey silty sediments including mollusk shell; Mulinia edulis, Mytilus chilensis, Aulacomya atra and Yoldia sp. Besides, dinoflagelate cysts, covers of benthonic foraminifera and copepod eggs are dominant. The microflora is represented by sporomorphs and fresh to salty water microplancton. Radiocarbon dates on Mulinia edulis shells yielded ages of 8094 ± 43 (AA74047 and 8167 ± 43 (AA74048 yr B.P. At Arroyo Baliza, clayey silts were found including Venus antiqua, Aulacomya atra, Mytilus chilensis, among others, accompanied by acritarchs and remnants of copepods. This association suggests marginal marine environments, with low to moderate salinity, and high nutrient concentration in the surface waters. Radiocarbon dating on Venus antiqua shells yielded 2844 ± 34 yr B.P. (AA74046. Marine deposits of the Aserradero

  11. Ethnoarchaeology of hunter‐fisher‐gatherers societies in the Beagle Channel (Tierra del Fuego): ethnographical sources and social simulation

    OpenAIRE

    Briz i Godino, Ivan; Izquierdo Millán, Luis Rodrigo; Álvarez, Myrian; Caro, Jorge; Galán Ordax, José Manuel; Santos Martín, José Ignacio; Zurro, Débora

    2014-01-01

    Research from the Beagle Channel (Tierra del Fuego) offers a rich ethnographic and historical record produced by the late inclusion of Tierra del Fuego in the industrial world (the Beagle Channel was discovered by R. Fitz- Roy in 1830). This is an interesting frame for using new techniques (social simulation by Agent Based Modelling (ABM)) to generate new hypotheses in archaeology. In this case, the hypothesis is focused on the role of social cooperation in Yámana hunter-fisher-ga...

  12. Heavy metal concentrations in litteral sediments from the Beagle Channel, Tierra del Fuego, Argentina.

    Science.gov (United States)

    Amin, O; Ferrer, L; Marcovecchio, J

    1996-07-01

    For the first time the concentration of trace metals (Fe, Pb, Cu, Zn, Cd and total Hg) of sediments from the coastal zone of the Beagle Channel (Tierra del Fuego, in Southern Argentina) were measured. Atomic absorption spectrophotometry was utilized in order to determine the metal contents. The level of metals as observed in the sediments was recognized as the natural background, even though the use of normalization of lead, copper, and zinc to iron allowed the identification of the main sources of metal pollution for this environment. In order to develop future environmental monitoring programmes for the area of Ushuaia city and the Beagle Channel, the present results need to be considered. PMID:24193396

  13. Baseline trace metals in gastropod mollusks from the Beagle Channel, Tierra del Fuego (Patagonia, Argentina).

    Science.gov (United States)

    Conti, Marcelo Enrique; Stripeikis, Jorge; Finoia, Maria Grazia; Tudino, Mabel Beatriz

    2012-05-01

    With the aim to evaluate the mollusk Nacella (P)magellanica as biomonitor of elemental pollution in seawater of the Beagle Channel, more than one hundred individuals of the gastropod were sampled, separated in viscera and muscle, and then examined with respect to the accumulation of Cd, Cr, Cu, Ni, Pb and Zn. Collection was performed in seven strategic locations along 170 km of the coastal area of the Beagle Channel (Tierra del Fuego, Argentina) in two campaigns during 2005 and 2007. Samples of surrounding seawater in the different sites were obtained and tested for the same metals as well. The accumulation capacity of Nacella (P)magellanica and thus its aptitude as biomonitor, was evaluated through the calculus of the preconcentration factors of the metals assayed. A discussion involving the comparison with other mollusks previously tested will be given. Several statistical approaches able to analyze data with environmental purposes were applied. Non parametric univariate tests such as Kruskal-Wallis and Mann-Whitney were carried out to assess the changes of the metal concentrations with time (2005 and 2007) in each location. Multivariate methods (linear discriminant analysis on PCA factors) were also applied to obtain a more reliable site classification. Johnson's probabilistic method was carried out for comparison between different geographical areas. The possibility of employing these results as heavy metals' background levels of seawater from the Beagle Channel will be debated. PMID:22350107

  14. Exploraciones osteológicas de la salud de las poblaciones humanas del Canal Beagle

    OpenAIRE

    Suby, Jorge A.; Zangrando, Francisco Atilio; Piana, Ernesto Luis

    2011-01-01

    Algunas evidencias acerca de la salud de las poblaciones aborígenes han comenzado a ser reportadas en varias regiones de Patagonia Austral. Por el contrario, hasta el momento carecemos de información comparable para la región del canal Beagle. El objetivo de este trabajo es comunicar los resultados de las investigaciones bioarqueológicas y paleopatológicas de los restos humanos recuperados en excavaciones realizadas en la margen norte del canal durante la primera década del siglo XXI. Estos e...

  15. Growth and production of the venerid bivalve Eurhomalea exalbida in the Beagle Channel, Tierra del Fuego

    OpenAIRE

    Lomovasky, B.; Brey, Thomas; Morriconi, E.; Calvo, J.

    2002-01-01

    Growth, mortality and productivity of the hard clam E. exalbida from Ushuaia Bay, Beagle Channel were investigated. The parameters of the von Bertalanffy growth function were estimated to be H = 73.98 mm, K = 0.180 y 1, t0 = 0.147 y. Maximum individual production amounted to 2.742 g shell free wet mass (SFWM) at 49.5 mm shell height. Animals between 40 mm and 70 mm shell height contribute most to overall population somatic production P of 133.89 g SFWM m-2 y-1. Mean annual biomass B amounted ...

  16. Growth and production of the venerid bivalve Eurhomalea exalbida in the Beagle Channel, Tierra del Fuego

    Science.gov (United States)

    Lomovasky, Betina J.; Brey, Thomas; Morriconi, Elba; Calvo, Jorge

    2002-11-01

    Growth, mortality and productivity of the hard clam Eurhomalea exalbida from Ushuaia Bay, Beagle Channel, were investigated. The parameters of the von Bertalanffy growth function were estimated to be H ∞ = 74 mm, K = 0.18 y -1, t 0 = 0.15 y. Maximum individual production amounted to 2.74 g shell-free wet mass (SFWM) at 49.5 mm shell height. Animals between 40 mm and 70 mm shell height contributed most to overall population somatic production P of 134 g SFWM m -2 y -1. Mean annual biomass B amounted to 1123 g SFWM m -2 y -1. Annual P/B ratio and mortality rate Z were estimated to be 0.12 y -1 and 0.14 y -1, respectively. Slow growth and low turnover make this population less suitable for sustainable commercial exploitation.

  17. Arqueología en el Canal Beagle (Tierra del Fuego, Argentina)

    OpenAIRE

    Vila-Mitjà, Assumpció; Orquera, Luis; Piana, Ernesto Luís; Estévez Escalera, Jordi; Riker YLL AGUIRRE

    1985-01-01

    La relativa buena documentación etnográfica, la riqueza arqueológica inaudita, la conservación del ecosistema y la simplicidad de las comunidades animales y vegetales, hacen que el trabajo de experimentación en esta zona, con diferentes modelos explicativos, presente unas condiciones óptimas para su realización.

  18. Heavy metal concentrations and biomarkers of oxidative stress in native mussels (Mytilus edulis chilensis) from Beagle Channel coast (Tierra del Fuego, Argentina).

    Science.gov (United States)

    Duarte, Claudia A; Giarratano, Erica; Amin, Oscar A; Comoglio, Laura I

    2011-08-01

    The aim of this study was to evaluate the usefulness of oxidative stress biomarkers of pollution in native mussels Mytilus edulis chilensis from the Beagle Channel. Spatial and seasonal variations of catalase, glutathione-S-transferase and lipid peroxidation in gills and digestive gland were analyzed in relation to environmental parameters, heavy metals in sediment and in tissue. Four sites with anthropogenic impact and a control site were selected and monitored during the four seasons of 2007. We found significant differences among sites in concentrations of dissolved nutrients and heavy metals in sediments, with the highest values recorded at sites with anthropogenic pressure. Different patterns were observed between concentrations of metals in tissues and in sediments suggesting differences in bioavailability. There were also significant differences in biomarker responses among sites, despite the strong seasonal variability. Our results showed relatively moderate levels of pollution in the study area as a result of urban influences. PMID:21704346

  19. Análisis comparativo osteológico y dentario de dos cazadores tardíos de fauna marina de Isla Grande de Tierra del Fuego, Argentina

    OpenAIRE

    Kozameh, Livia Febes; Testa, N.

    2003-01-01

    De una fosa excavada en un conchero, al este de la ciudad de Ushuaia, sobre el Canal Beagle, fueron exhumados, de un entierro primario, restos de un esqueleto humano casi completo. El resto se halló asociado a un raspador de vidrio, elemento por el que se lo asignaría a momentos tardíos. Estos restos corresponden a un adulto masculino de avanzada edad a la muerte. En excavaciones realizadas en Bahía Valentín, Península Mitre, extremo sudoriental de la Isla Grande de Tierra del Fuego, fue enco...

  20. Asentamiento de estadios tempranos de las centollas Lithodes santolla y Paralomis granulosa (Decapoda: Lithodidae en colectores artificiales pasivos en el Canal Beagle, Argentina Recruitment of young-of-the-year lithodids Lithodes santolla and Paralomis granulosa in artificial passive collectors in the Beagle Channel, Argentina

    Directory of Open Access Journals (Sweden)

    Federico Tapella

    2006-11-01

    Full Text Available En el sector argentino del Canal Beagle, la pesquería de Lithodes santolla se encuentra colapsada y cerrada desde 1994, mientras que la del centollón Paralomis granulosa está estable, aunque por el crecimiento lento de la población no podría soportar alta presión de pesca. En este estudio se determinó la profundidad de reclutamiento de los estadios bentónicos tempranos y se evaluó la efectividad de colectores artificiales pasivos como oferta de refugio. En 2002 se fondearon colectores "SAC" en tres estratos de profundidad: 10(-20, 20-40 y 40-90 m. En 2003, se colocaron colectores "Cajón" en dos estratos de profundidad: 10(-20 y 20-40 m. En marzo de cada temporada se retiraron los colectores y se registró el número y tamaño de L. santolla y P. granulosa, y se determinó el taxón más abundante en cada colector. Los individuos del primer año de vida, i.e. The L. santolla fishery in the Argentinean sector of the Beagle Channel collapsed and has been closed since 1994. Landings of P. granulosa in this sector are stable, but will not allow it to withstand heavy fishing pressure. In this study, we determined the recruitment depth of the early benthic stages of both lithodid species, and evaluated the effectiveness of passive artificial collectors as potential sources of refuge. In 2002, "SAC" collectors were deployed in three depth strata: 10(-20, 20-40, and 40-90 m. In 2003, "Cajón" collectors were deployed in two depth strata: 10(-20 and 20-40 m. The collectors were retrieved, respectively, in March 2003 and 2004, and the number and size of L. santolla and P. granulosa were recorded, along with the most abundant taxon in each collector. For both species, young-of-the-year individuals (i.e., < 5 mm carapace length were found recruited in the collectors. Recruitment of the first benthic stages of L. santolla and P. granulosa occurs only to 40 m depth. L. santolla appears to select environments dominated by polychaetes and, to a lesser

  1. Penis Allotransplantation in Beagle Dog

    OpenAIRE

    Yongbin Zhao; Weilie Hu; Lichao Zhang; Fei Guo; Wei Wang; Bangqi Wang; Changzheng Zhang

    2016-01-01

    This is an original research of penis allotransplantation. The paper presents an experiment allogenic penis transplantation model in Beagles, with a focus on recovery of blood supply and changes in tissue architecture. Twenty adult Beagles were allocated to 10 pairs for penile transplantation. After operation, the skin and glans were observed. If adverse symptoms occurred, the transplanted penis was resected and pathologically examined. Frequency of urination, urinary stream, and patency leve...

  2. Dental radiology: ageing changes in permanent teeth of Beagle dogs

    International Nuclear Information System (INIS)

    Radiographic interpretation of dental or periodontal disease is dependent in part on an understanding of ageing changes, A progressively ageing colony of healthy beagle dogs (120 to 3759 days) was studied by use of high-detail radiographs made following the death of the dog. Morphological features whose radiographic appearance was found to be especially age-dependent were: root canal size, both vertical and horizontal alveolar bone resorption, visualisation of the lamina dura dentis, and detection of hypercementosis. Understanding of these ageing changes is necessary to avoid over-diagnosis of disease

  3. BeagleBone media center

    CERN Document Server

    Lewin, David

    2015-01-01

    Whether you are a hobbyist or a professional, this book will get you fully equipped to resolve the most commonly occurring media-related challenges. If you want to expand your horizons beyond lighting an LED and push the limits of your board, this is just the book for you. Working knowledge of BeagleBone is assumed.

  4. The Legacy of Beagle 2

    Science.gov (United States)

    Pillinger, Judith; Bridges, John; Sims, Mark; Clemmet, Jim; Wright, Ian

    2015-04-01

    The Beagle 2 lander spun off from the ESA Mars Express spacecraft on 19 December 2003 and headed off towards Isidis Planitia on Mars. The scheduled landing of the 60 kg lander was 6 days later on Christmas morning, 25 December. It is universally known that no signal was received from the lander and its fate remained unknown. What is not questioned is the impact that the mission, and not least its charismatic leaders headed by the late Professor Colin Pillinger, had on the general public of the UK, Europe and worldwide. More than a decade after Beagle 2 was last seen, we review the legacy of the mission on the public perception of the value of space exploration, economically, commercially and cultural, and look forward to an expanding programme. The spin off from Beagle 2 science and technology into terrestrial applications will be addressed as will the ongoing career destinations of many of the original team; both supporting the significance that the mission had on determining the future pathway of space science and exploration in Europe and beyond. The ongoing search for evidence that Beagle 2 did in fact land as planned on Mars will be addressed and images from Mars orbiting spacecraft assessed.

  5. La Tierra vista como exoplaneta

    OpenAIRE

    Antígona Segura

    2010-01-01

    La Tierra, como único ejemplo de planeta habitable, nos da los primeros elementos para caracterizar el espectro de planetas de tipo terrestre alrededor de otras estrellas que podrían ser detectados en el transcurso de la próxima década gracias a misiones como CoRoT y Kepler y caracterizados por las misiones Terrestrial Planet Finder y Darwin. En este artículo se compendian los estudios que utilizan a la Tierra para determinar las posibles características de mundos habitables alrededor de otra...

  6. Tierra del Fuego, Argentina, South America

    Science.gov (United States)

    1991-01-01

    The Mitre Peninsula is the easternmost tip of Tierra del Fuego, Argentina, (54.5S, 65.5W). Early winter snow can be seen on this south tip of the Andes Mountains. These same mountains continue underwater to Antarctica. The Strait of Magellan, separating the South American mainland from Tierra del Fuego is off the scene to the north and west, but the Strait of LeMaire, separating Tierra del Fuego from the Isla de los Estados can be seen.

  7. La Memoria De Nuestra Tierra: Colorado

    Science.gov (United States)

    Baca, Judy

    2005-01-01

    La Memoria de Nuestra Tierra combines a meticulously hand-painted landscape with historic photographs in a seamless blend imprinted on the holographic-like surface of a metallic coated substrate. The mural for the Denver International Airport, entitled La Memoria de Nuestra Tierra is a breakthrough in digital murals, printed digitally on a…

  8. canal24

    Data.gov (United States)

    California Department of Resources — Canal system center lines in the Central Valley of California and adjacent areas captured from 1:24,000-scale USGS topographic maps. Updates and modifications made...

  9. UK and ESA announce Beagle 2 inquiry

    CERN Multimedia

    2004-01-01

    An investigation will be held to identify the potential reasons surrounding the inability to communicate with the British-led Beagle 2 lander once it parted from the mother ship on Christmas day (1 page).

  10. Análisis comparativo osteológico y dentario de dos cazadores tardíos de fauna marina de Isla Grande de Tierra del Fuego, Argentina

    Directory of Open Access Journals (Sweden)

    Kozameh, Livia Febes

    2003-01-01

    Full Text Available De una fosa excavada en un conchero, al este de la ciudad de Ushuaia, sobre el Canal Beagle, fueron exhumados, de un entierro primario, restos de un esqueleto humano casi completo. El resto se halló asociado a un raspador de vidrio, elemento por el que se lo asignaría a momentos tardíos. Estos restos corresponden a un adulto masculino de avanzada edad a la muerte. En excavaciones realizadas en Bahía Valentín, Península Mitre, extremo sudoriental de la Isla Grande de Tierra del Fuego, fue encontrado, entre otros restos, un esqueleto completo de un individuo masculino, adulto maduro al momento de la muerte. Entre los hallazgos obtenidos en el área fueron recuperados, entre otros, restos industriales europeos, posiblemente productos de naufragios. Esta evidencia avalaría su ubicación temporal en momentos posteriores a la llegada de los europeos. El objetivo de este trabajo ha sido realizar un análisis comparativo de rastros fisiológicos y patológicos del esqueleto y del aparato masticatorio, en ambos ejemplares. Este análisis revela marcadas diferencias entre ambos restos, que refieren tanto a su distribución esqueletal como asimismo a la intensidad de la injuria. Contar con dos esqueletos de características afines posibilitó el estudio comparativo. El análisis de los resultados señala diferencias del estado de salud y enfermedad en uno y otro cazador. Esas diferencias se manifiestan tanto en el esqueleto post-craneano como, muy especialmente, en el aparato masticatorio.

  11. Construcciones a base de tierra

    Directory of Open Access Journals (Sweden)

    Alvarez Alonso, Marina

    1984-11-01

    oriented towards dissipating possible prejudices which exist with regard to earthen constructions.Trabajo realizado y basado en las nuevas posibilidades de las construcciones con tierra, una vez considerado su interés en épocas anteriores y las nuevas posibilidades que ofrece ante la crítica impuesta por la crisis de la energía. Se hacen consideraciones sobre las necesidades de vivienda previstas hasta el año 2000 y otros parámetros que vuelven a ser importantes al confrontarlos económicamente con los materiales industrializados, sistemas de construcción, soluciones orientadas a los países en vías de desarrollo, etc. Continúa el trabajo con las primeras vías de experimentación práctica desarrolladas por el equipo de trabajo de viviendas de bajo coste orientadas a la búsqueda y promoción de recursos locales y abundantes como el material tierra, vías de experimentación que comienzan con el conocimiento por el equipo de técnicas y materiales durante el curso realizado en Ciadueña (Soria. Se describen aspectos técnicos del material tierra desarrollados paralelamente a la experiencia práctica inicial y orientada a la elección idónea de los componentes, una vez confrontada la información bibliográfica relacionada con el tema. Entre las consideraciones técnicas se llega a una exposición más exhaustiva sobre: 1 Las técnicas existentes: ladrillos de adobe, tierra apisonada (tapial, etc. 2 Porcentajes idóneos de los componentes para la elección de los materiales preferibles en cada una de las técnicas anteriores. 3 Consideraciones de los aspectos físicos y mecánicos de la maquinaria existente y en experimentación, así como de las posibilidades respecto a su puesta en obra, costes comparativos, etc. 4 Estudio de las posibilidades para mejorar las características del material tierra mediante diferentes técnicas de estabilización (compactación y correcciones granulométricas, estabilizantes fisicoquímicos, betunes, productos

  12. Bloque de tierra comprimida como material constructivo

    Directory of Open Access Journals (Sweden)

    Karen Tatiana Arteaga Medina

    2012-05-01

    Full Text Available La construcción con tierra es poco usada en la actualidad debido a la falta de difusión e investigación, y a que es relacionada con la pobreza; por ende, se desaprovechan muchas de sus ventajas, como la abundancia demateria prima, la localización, la disponibilidad, el reciclaje, la producción sin consumo de energía (calorífica, el bajo costo y la resistencia –con un adecuado estudio del material tierra, de la estructuración y del suelo de fundación–; otras de sus ventajas son el aislamiento térmico y acústico. Con el paso del tiempo se han mejorado las técnicas constructivas con tierra, realizando estabilizaciones e implementando el uso de maquinaria y herramienta mecánica para elaborar bloques de tierra comprimida, y así facilitar el trabajo y obtener mayor rendimiento. Este artículo presenta la tierra como material constructivo, las técnicas o sistemas constructivos, los bloques de tierra comprimida (BTC y algunos ensayos realizados a estos bloques.

  13. Bloque de tierra comprimida como material constructivo

    Directory of Open Access Journals (Sweden)

    Óscar Javier Gutiérrez Junco

    2011-07-01

    Full Text Available La construcción con tierra es poco usada en la actualidad debido a la falta de difusión e investigación, y a que es relacionada con la pobreza; por ende, se desaprovechan muchas de sus ventajas, como la abundancia demateria prima, la localización, la disponibilidad, el reciclaje, la producción sin consumo de energía (calorífica, el bajo costo y la resistencia –con un adecuado estudio del material tierra, de la estructuración y del suelo de fundación–; otras de sus ventajas son el aislamiento térmico y acústico. Con el paso del tiempo se han mejorado las técnicas constructivas con tierra, realizando estabilizaciones e implementando el uso de maquinaria y herramienta mecánica para elaborar bloques de tierra comprimida, y así facilitar el trabajo y obtener mayor rendimiento. Este artículo presenta la tierra como material constructivo, las técnicas o sistemas constructivos, los bloques de tierra comprimida (BTC y algunos ensayos realizados a estos bloques.

  14. CANAL code

    International Nuclear Information System (INIS)

    The CANAL code presented here optimizes a realistic iron free extraction channel which has to provide a given transversal magnetic field law in the median plane: the current bars may be curved, have finite lengths and cooling ducts and move in a restricted transversal area; terminal connectors may be added, images of the bars in pole pieces may be included. A special option optimizes a real set of circular coils

  15. A second, cryptic species of the soft coral genus Incrustatus (Anthozoa: Octocorallia: Clavulariidae) from Tierra del Fuego, Argentina, revealed by DNA barcoding

    Science.gov (United States)

    McFadden, Catherine S.; van Ofwegen, Leen P.

    2013-03-01

    The encrusting soft coral Incrustatus comauensis is a common denizen of hard substrates in the shallow sub-tidal zone from the central Chilean fjords to the Cape Horn region of southern South America. DNA barcoding of specimens collected from the Beagle Channel, Tierra del Fuego, Argentina, revealed the presence of a second, cryptic species of Incrustatus that is syntopic with I. comauensis. We describe Incrustatus niarchosi, a new species that can be distinguished morphologically from I. comauensis by differences in the microscopic ornamentation of the coenenchymal sclerites. To date, I. niarchosi n. sp. is known only from the Beagle Channel. A population of I. comauensis discovered in the intertidal zone in eastern Tierra del Fuego represents a new record of the species for that habitat and geographic region. Although the intertidal population is also distinct genetically, it is morphologically indistinguishable from sub-tidal Chilean populations of I. comauensis, and at present, there is insufficient evidence to support its status as a separate species.

  16. BeagleBone for secret agents

    CERN Document Server

    Datko, Josh

    2014-01-01

    If you have some experience with the BeagleBone or similar embedded systems and want to learn more about security and privacy, this book is for you. Alternatively, if you have a security and privacy background and want to learn more about embedded development, this book is for you. You should have some familiarity with Linux systems and with the C and Python programming languages.

  17. Root canal irrigants

    OpenAIRE

    Kandaswamy Deivanayagam; Venkateshbabu Nagendrababu

    2010-01-01

    Successful root canal therapy relies on the combination of proper instrumentation, irrigation, and obturation of the root canal. Of these three essential steps of root canal therapy, irrigation of the root canal is the most important determinant in the healing of the periapical tissues. The primary endodontic treatment goal must thus be to optimize root canal disinfection and to prevent reinfection. In this review of the literature, various irrigants and the interactions between irrigants are...

  18. Mamary neoplasia in a closed beagle colony

    International Nuclear Information System (INIS)

    The incidence rate of mammary neoplasia in a large colony of beagles and its relationship to internal skeletal and/or liver radiation, age, relatively late ovariectomy (4 years and older), endometritis, parity status, and adrenal weight was examined. Of these various factors, age was the only condition that was clearly correlated with changes in the mammary tumor incidence. The rate became significant at approximately eight years of age and increased progressively throughout the successively older age classes. Within the female dogs, the incidence of mammary cancer was higher that that of any other form of spontaneous malignancy

  19. Oferta y demanda del recurso agua en el distrito de adecuación de tierras de rio frio

    OpenAIRE

    Arango Tobón, Julio César

    1997-01-01

    El conocimiento de la oferta y demanda del recurso agua en el distrito de adecuación de tierras de Río Frío, le permite a ASORIOFRIO, entidad encargada de la administración, operación y conservación del distrito, disponer de una herramienta técnica para efectuar la entrega de agua a los usuarios, de acuerdo a las condiciones climáticas, de suelos, a la implantación de cultivos, sistemas de canales y diversos parámetros agrícolas. El trabajo realizado concluye que existe una baja disponibil...

  20. Optic Canal: Microanatomic Study

    OpenAIRE

    Slavin, Konstantin V.; Dujovny, Manuel; Soeira, Gelson; James I Ausman

    1994-01-01

    The microsurgical anatomy of the optic canal was defined on 20 cadaveric specimens. Anatomic parameters of the optic canal, optic nerve, ophthalmic artery, and adjacent structures were measured, and relations of these structures were noted. Five variants of the course of the ophthalmic artery relative to the optic nerve in the optic canal were found. Various aspects of microsurgery of the optic canal are discussed in relation to anatomic findings.

  1. 224Ra toxicity from a pilot study in beagles

    International Nuclear Information System (INIS)

    Toxicity data are reported for 20 beagles given single intravenous injections of 224Ra in 1963 or 1968. The injection of 1 μCi 224Ra/kg gave an average skeletal dose of about 54 rad in young adult beagles. Two dogs died of acute radiation sickness, 6 with bone sarcomas, 6 from other causes, and 6 were still alive on 31 March 1977. The acutely lethal dosage (LD/sub 50/30)/ for a single injection of 224 Ra in young adult beagles seems to lie between 10 and 20 μCi 224Ra/kg, with an average skeletal dose between 500 and 1000 rad

  2. Gente, tierra y agua en la Amazonia

    OpenAIRE

    Buitrago Garavito, Ana Isabel; Jiménez, Eliana; Tobón, Marco Alejandro; Gendrau Acho, Sheila; Ciro Rodríguez, Estefanía; Ciro Rodríguez, Alejandra; Trujillo Osorio, Catalina; Currea Dereser , Alejandra; Torres Zambrano, Nestor Ned; Serrato Hurtado, Clemencia; Santiago R. Duque; Moreno Hurtado, Flavio; Peñuela, Maria Cristina; Lloyd, Jon; Patiño, Sandra

    2008-01-01

    Con el ánimo de contribuir a la comprensión social, histórica y económica de la gente que habita la región amazónica y al entendimiento del funcionamiento de sus ecosistemas surge el libro Gente, tierra y agua en la Amazonia. lmani mundo III. Este libro es el tercero de la serie Imani mundo, la cual expone trabajos de investigación en la región amazónica tanto en aspectos sociales como en aspectos ecológicos, realizados por el instituto Amazónico de Investigaciones IMANI de la Universidad Nac...

  3. Pathology associated with inhaled plutonium in beagles

    International Nuclear Information System (INIS)

    The pathology associated with the inhalation of plutonium was studied in beagle dogs given a single exposure to aerosols of 239PuO2, 238PuO2, or 239Pu(NO3)4. The temporal-spatial relationships between plutonium deposition and the development of lesions in dogs were evaluated up to 11 years, 8 years, or 5 years, respectively, after exposures, resulting in initial lung burdens ranging from ∼2 to ∼5500 nCi. Exposure of the lung to high dose levels produced a spectrum of progressively more severe morphological changes, ranging from radiation pneumonitis to fibrosis. Lung tumors occurred at exposure levels that did not result in early death from radiation pneumonitis or fibrosis. Bronchiolar-alveolar carcinomas, papillary adenocarcinomas, epidermoid carcinomas, and combined epidermoid and adenocarcinomas were observed. Sclerosing tracheobronchial lymphadenitis, radiation osteodystrophy, osteosarcoma, and hepatic adenomatous hyperplasia were the principal extrapulmonary lesions resulting from translocation of plutonium. 15 refs., 2 tabs

  4. Comprobaciones resistentes de elementos constructivos de tierra

    Directory of Open Access Journals (Sweden)

    Estrada, Enrique

    1986-11-01

    Full Text Available This work has the purpose to compare, by means of different tests on adobe bricks and masonry, the obtained resistant properties and those of other similar works carried out in countries having a wide tradition and knowledge about earth as construction material. Elements (adobe bricks and blocks have been tested to compression and bending, and masonry made of those elements to compression and diagonal compression.El presente trabajo pretende comparar, por medio de distintos ensayos sobre elementos y fábricas de mampostería de tierra, las propiedades resistentes obtenidas con las de otros trabajos similares realizados en países con dilatada tradición y conocimiento de la tierra como material de construcción. Se han ensayado elementos (adobes y bloques a compresión y flexotracción y fábricas formadas por conjuntos de los mismos a compresión y a compresión diagonal.

  5. Root canal irrigants

    Directory of Open Access Journals (Sweden)

    Kandaswamy Deivanayagam

    2010-01-01

    Full Text Available Successful root canal therapy relies on the combination of proper instrumentation, irrigation, and obturation of the root canal. Of these three essential steps of root canal therapy, irrigation of the root canal is the most important determinant in the healing of the periapical tissues. The primary endodontic treatment goal must thus be to optimize root canal disinfection and to prevent reinfection. In this review of the literature, various irrigants and the interactions between irrigants are discussed. We performed a Medline search for English-language papers published untill July 2010. The keywords used were ′root canal irrigants′ and ′endodontic irrigants.′ The reference lists of each article were manually checked for additional articles of relevance.

  6. Tierra Caliente, Michoacán

    Directory of Open Access Journals (Sweden)

    C. I. Villa

    2008-01-01

    Full Text Available Los sistemas de producción ganaderos de la región de Tierra Caliente están vinculados al manejo agrosilvopastoril, aprovechando una amplia gama de recursos forrajeros naturales, siendo las familias quienes conducen la administración y aprovechamiento de dichos recursos. Se buscó definir las características, recursos forrajeros aprovechables e insumos alimenticios, estimando su calidad nutricional, con el fin de encontrar estrategias de alimentación de ganado que reduzcan al mínimo el uso de insumos externos al interior de las unidades productivas. Se trabajó en comunidades del municipio de Tuzantla, en la región de Tierra Caliente del estado de Michoacán. El método incluye la recolección de información por medio de encuestas aplicadas a productores campesinos, durante el ciclo productivo 2007. Se analizaron de 200 a 300 g de 41 muestras de alimentos con el método de Wendee, para analizar su composición química. Se encontró que para la región de Tierra Caliente existe un sistema de producción bovina de mediana escala, semi-estabulado y trashumante que, en promedio, tiene 250 a 260 ha y 86 cabezas de ganado destinado a la producción de carne y pie de cría, y que producen 9.2 l/vaca/día; con esta leche se elabora queso a razón de 1kg de queso por cada 10 litros de leche. Se identificó, también, el uso de seis ingredientes fundamentales que componen dos dietas básicas, cuya composición química detectada fue de 10.2- 13.9% (PC, 7.9-11.8% (FC, 62.8-67.9% (ELN, 1.4-5% (EE y 1.9-8.8% (cenizas. Por tanto, se concluye que los ganaderos cubren los requerimientos nutricionales con base en el alto uso de concentrados, dejando los forrajes para satisfacer las necesidades de consumo de su ganado. Por esto, se requiere establecer un sistema de balanceo de raciones que permita optimizar los recursos

  7. Root canal irrigation

    NARCIS (Netherlands)

    L. van der Sluis; C. Boutsioukis; L.M. Jiang; R. Macedo; B. Verhaagen; M. Versluis

    2015-01-01

    The aims of root canal irrigation are the chemical dissolution or disruption and the mechanical detachment of pulp tissue, dentin debris and smear layer (instrumentation products), microorganisms (planktonic or biofilm), and their products from the root canal wall, their removal out of the root cana

  8. The Root Canal Biofilm

    NARCIS (Netherlands)

    Sluis, van der L.W.M.; Boutsioukis, C.; Jiang, L.M.; Macedo, R.; Verhaagen, B.; Versluis, M.; Chávez de Paz, E.; Sedgley, C.M.; Kishen, A.

    2015-01-01

    The aims of root canal irrigation are the chemical dissolution or disruption and the mechanical detachment of pulp tissue, dentin debris and smear layer (instrumentation products), microorganisms (planktonic or biofilm), and their products from the root canal wall, their removal out of the root cana

  9. Evaluation of nanoparticle delivered cisplatin in beagles

    Science.gov (United States)

    Feldhaeusser, Brittany; Platt, Simon R.; Marrache, Sean; Kolishetti, Nagesh; Pathak, Rakesh K.; Montgomery, David J.; Reno, Lisa R.; Howerth, Elizabeth; Dhar, Shanta

    2015-08-01

    Intracranial neoplasia is a significant cause of morbidity and mortality in both human and veterinary patients, and is difficult to treat with traditional therapeutic methods. Cisplatin is a platinum (Pt)-containing chemotherapeutic agent approved by the Food and Drug Administration; however, substantial limitations exist for its application in canine brain tumor treatment due to the difficulty in crossing the blood-brain barrier (BBB), development of resistance, and toxicity. A modified Pt(iv)-prodrug of cisplatin, Platin-M, was recently shown to be deliverable to the brain via a biocompatible mitochondria-targeted lipophilic polymeric nanoparticle (NP) that carries the drug across the BBB and to the mitochondria. NP mediated controlled release of Platin-M and subsequent reduction of this prodrug to cisplatin allowed cross-links to be formed with the mitochondrial DNA, which have no nucleotide excision repair system, forcing the overactive cancer cells to undergo apoptosis. Here, we report in vitro effects of targeted Platin-M NPs (T-Platin-M-NPs) in canine glioma and glioblastoma cell lines with results indicating that this targeted NP formulation is more effective than cisplatin. In both the cell lines, T-Platin-M-NP was significantly more efficacious compared to carboplatin, another Pt-based chemotherapy, which is used in the settings of recurrent high-grade glioblastoma. Mitochondrial stress analysis indicated that T-Platin-M-NP is more effective in disrupting the mitochondrial bioenergetics in both the cell types. A 14-day distribution study in healthy adult beagles using a single intravenous injection at 0.5 mg kg-1 (with respect to Platin-M) of T-Platin-M-NPs showed high levels of Pt accumulation in the brain, with negligible amounts in the other analyzed organs. Safety studies in the beagles monitoring physical, hematological, and serum chemistry evaluations were within the normal limits on days 1, 7, and 14 after injection of either 0.5 mg kg-1 or 2 mg kg

  10. Hematologic effects of inhaled plutonium in beagles

    International Nuclear Information System (INIS)

    Beagle dogs were exposed, by inhalation, 5 to 11 years ago, to aerosols of 239PuO2, 238PuO2, or 239Pu(NO3)4, at six dose levels resulting in initial lung burdens ranging from ∼2 to ∼5500 nCi. Translocation of the plutonium to extrapulmonary sites was related to the physical-chemical characteristics of the plutonium compound. The highly insoluble 239PuO2 was retained primarily in the lung and associated lymph nodes, whereas 239Pu(NO3)4 was much more soluble and translocated relatively rapidly to the skeleton and other extrapulmonary tissues. The 238PuO2 was intermediate in solubility and translocation characteristics. The hematologic effects of plutonium inhalation were most pronounced on lymphocyte populations. Evidence suggests that these effects result from irradiation of lymphocytes via the pulmonary lymph nodes with insoluble 239PuO2, and via these same lymph nodes, extrapulmonary lymph nodes, and bone marrow lymphocytes with the more soluble forms, i.e., 238PuO2 and 239Pu(NO3)4. There is no evidence suggesting that these exposures increase the risk of developing myeloid or lymphoid neoplasia. 8 refs., 4 figs., 3 tabs

  11. Inferencias paleodietarias mediante isótopos estables en restos óseos humanos provenientes de Tierra del Fuego, Argentina

    Directory of Open Access Journals (Sweden)

    Schinder, Gala

    2003-01-01

    Full Text Available Las actuales lineas de acción vinculadas al uso de isótopos estables en la Isla Grande de Tierra del Fuego están orientándose a acotar factores de variación (especialmente la variación espacial y temporal y al cruce con otras lineas de evidencias como los estilos de vida. A partir de la ocupación europea en el Siglo XVIII se modificó el estilo de vida de las poblaciones históricas de la región. El presente trabajo tiene como objetivos explorar la variabilidad en cuanto al tipo de recursos consurnidos por hombres y mujeres a partir de la información isotópica obtenida de huesos de individuos provenientes de diferentes sectores geográficos (Norte, Sudeste y Beagle y la determinación de la composición de la dieta en términos de contenido proteico. Los datos isotópicos se complementaron con información etnográfica. El análisis Kruskal-Wallis sugiere que existen diferencias significativas entre los diferentes sectores geográficos, pero no se registraron diferencias significativas entre hombres y mujeres. Asimismo, los isótopos indican que los individuos del Sudeste consumían preferentemente dietas más ricas en proteínas que sus vecinos del norte de la Isla. En los últimos años, ha crecido el interé por los estudios orientados al análisis de la división sexual del trabajo en sociedades cazadoras recolectoras. Este trabajo constituye un primer aporte para evaluar la variabilidad en cuanto a las diferencias en la obtención de recursos entre sexos y el tipo de dieta en individuos históricos de Tierra del Fuego.

  12. Design of canals

    CERN Document Server

    Swamee, P K

    2015-01-01

    The book presents firsthand material from the authors on design of hydraulic canals. The book discusses elements of design based on principles of hydraulic flow through canals. It covers optimization of design based on usage requirements and economic constraints. The book includes explicit design equations and design procedures along with design examples for varied cases. With its comprehensive coverage of the principles of hydraulic canal design, this book will prove useful to students, researchers, and practicing engineers. End-of-chapter pedagogical elements make it ideal for use in graduate courses on hydraulic structures offered by most civil engineering departments across the world.

  13. La pesquería mixta de las centollas Lithodes santolla y Paralomis granulosa (Anomura: Lithodidae) en Tierra del Fuego, Argentina The mixed fishery for the king crabs Lithodes santolla and Paralomis granulosa (Anomura: Lithodidae) in Tierra del Fuego, Argentina

    OpenAIRE

    Gustavo A Lovrich

    1997-01-01

    En el Canal Beagle (55ºS; 66ºW), los individuos de dos especies simpátridas de litódidos, la centolla Lithodes santolla y el centollón Paralomis granulosa aparecen frecuentemente juntos en las trampas y por ello su pesquería se denomina mixta. Las dos especies difieren en su potencial reproductivo y por tanto en la tasa de reposición de individuos a la población. L. santolla es de mayor tamaño (máximo 180 mm de largo de caparazón, Lc y hasta 6 kg de peso), tiene un tiempo generacional de 6 añ...

  14. Incidencia de agenesia dental en perros Beagle. Resultados preliminares(Dental agenesis incidence in Beagle dogs. Preliminary results

    Directory of Open Access Journals (Sweden)

    Rodríguez Sosa

    2011-11-01

    Full Text Available ResumenEn el presente trabajo se examinaron 49 perros Beagle procedentes del CENPALAB que fueron mantenidos bajo el mismo régimen de convivencia, alimentación y manejo en el Bioterio de la Facultad de Medicina “Victoria de Girón” tributarios todos a estudios de implantes dentales.AbstractForty-nine Beagle dogs coming from CENPALAB were maintained under the same coexistence, feeding and handling regime in the Bioterio of Medicine High School “Victoria de Girón” tributary to studies of dental implant all them.

  15. Extreme Environments in Tierra del Fuego, Argentina

    Science.gov (United States)

    Schultz, C.; D'Antoni, H.; Burgess, S.; Zamora, J.; Skiles, J.

    2007-12-01

    The upper timberline of the Andes Cordillera on the island of Tierra del Fuego at the tip of South America is an environment subject to extreme conditions. In order to further understand this environment, ecosystem parameters were measured within two transects of the Andes at Glaciar Martial and Cerro Guanaco. The measurements included pH, soil temperature, soil moisture, nitrogen, sodium and potassium concentration, chlorophyll absorbance, and irradiance in the ultraviolet range (200-400 nm). These data comprise a survey that serves as a baseline for an intensive research program. Chlorophyll concentration and soil data were within the range of our observations at several other sites, from Lapataia Bay on the southwestern boundary with Chile, through the eastern end of Lake Fagnano. However, unusual levels of solar irradiance were found in the open sites of both transects while those in the forest exhibited lower UV values, suggesting strong absorption and/or reflection by the forest canopy. High levels of UV radiation damage important biomolecules and may be partially responsible for the presence of life forms such as the krummholz belt in the upper timberline. These UV values may be due to the effects of global ozone depletion and the ozone hole. The low temperatures, strong winds, snow and ice-covered soil and especially the exposure to UV radiation make this area an extreme environment for life.

  16. Monstrilloida (Crustacea: Copepoda) from the Beagle Channel, South America

    NARCIS (Netherlands)

    Suárez-Morales, E.; Ramírez, F.C.; Derisio, C.

    2008-01-01

    Monstrilloid copepods were collected during zooplankton surveys in the Beagle Channel at the southernmost end of South America. These specimens represent two species of Monstrillopsis, one of them undescribed, and one new species of Monstrilla. Monstrillopsis igniterra n. sp. is related to forms of

  17. Introducing Students to Darwin via the Voyage of HMS "Beagle"

    Science.gov (United States)

    Swab, Janice C.

    2010-01-01

    I use the diary that Darwin wrote during the voyage of HMS Beagle and recent images of a few of the places he visited to illustrate some comparisons between Darwin's world and ours. For today's students, increasingly committed to environmental issues, this may be an especially promising way to introduce Darwin.

  18. Mars orbiter redirected in bid to find Beagle

    CERN Multimedia

    2003-01-01

    "Mission controllers in Darmstadt, Germany, have successfully redirected Europe's Mars Express orbiter into a polar orbit, putting it on course for a last-ditch attempt to contact Beagle 2, the lander that has been missing since Christmas day when it should have touched down on the red planet" (1/2 page).

  19. La temperatura del interior de la tierra

    Directory of Open Access Journals (Sweden)

    Eslava R. Jesús A.

    1993-10-01

    Full Text Available The problem of defining the Earth interior temperature is analized from Heat Flow observations and the acceptance of convection processes in the mantle. Comparative analyses of thermal, adiabatic, and melting point profiles, allow to obtain the optimum temperature profile, wich fits the seismic model of a liquid external core.

    EI problema de definir la temperatura del interior de la Tierra, se analiza a partir de las observaciones del flujo térmico y la aceptación de procesos de convección en el manto.

    Análisis comparativos de perfiles térmicos, adiabáticos y de puntos de fusión, permiten obtener un perfil óptimo de distribución de temperaturas, que además satisface la observación sísmica de un núcleo externo líquido.

  20. Crepusculario a la Luz de Residencia en la Tierra

    OpenAIRE

    Hernández Álvarez, María Vicenta

    1997-01-01

    EL ESTUDIO DE AMADO ALONSO SOBRE LA OBRA DE NERUDA, RESIDENCIA EN LA TIERRA, ES DOBLEMENTE FECUNDO: PORQUE OFRECE AL MISMO TIEMPO EL ANALISIS Y LAS PISTAS NECESARIAS PARA COMPRENDER ESTA OBRA, Y UNA VISION CRITICA QUE PUEDE EXTENDERSE AL CONJUNTO DE LA OBRA DEL POETA. ENSEÑA UN PROCEDIMIENTO Y CONTAGIA UN ENTUSIASMO. ESTE ARTICULO ES EL INTENTO DE UNA LECTURA DE CREPUSCULARIO A LA LUZ DE RESIDENCIA EN LA TIERRA. EN ESTA LECTURA, CREPUSCULARIO SE REVELA COMO UNA PRIMERA Y FUNDAMENTAL ARTE POET...

  1. Canals, River Irrigation Company Canal, Published in 2002, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Canals dataset, was produced all or in part from Other information as of 2002. It is described as 'River Irrigation Company Canal'. Data by this publisher are...

  2. Canals, Yellowstone Feeder Canal, Published in 2002, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Canals dataset, was produced all or in part from Other information as of 2002. It is described as 'Yellowstone Feeder Canal'. Data by this publisher are often...

  3. Canals, Dry Gulch Canal, Published in 2002, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Canals dataset as of 2002. It is described as 'Dry Gulch Canal'. Data by this publisher are often provided in UTM coordinate system; in a Transverse Mercator...

  4. Canals, Lake Canal, Published in 2002, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Canals dataset, was produced all or in part from Other information as of 2002. It is described as 'Lake Canal'. Data by this publisher are often provided in...

  5. Canals, Little Blackhawk Canal, Published in 2002, Duchesne County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Canals dataset, was produced all or in part from Other information as of 2002. It is described as 'Little Blackhawk Canal'. Data by this publisher are often...

  6. Ear canal cholesteatoma.

    Science.gov (United States)

    Holt, J J

    1992-06-01

    Although cholesteatomas are more commonly found in the middle ear and the mastoid, the disease can occur in the external ear canal. All cases of ear canal cholesteatoma treated by the author were reviewed. There were nine ears in seven patients, who had an average age of 62 years. The lesions ranged in size from a few millimeters to extensive mastoid destruction. Smaller lesions can be managed by frequent cleaning as an office procedure. Larger lesions require surgery, either canaloplasty or mastoidectomy. The otolaryngologist should suspect this disease in the elderly. Microscopic examination of the ear with meticulous cleaning of all wax, especially in elderly patients, is most useful in detecting early disease. Frequent applications of mineral oil to the canal should be used in the management of the disease and to prevent recurrence. PMID:1376388

  7. Multistate nested canalizing functions

    CERN Document Server

    Adeyeye, J O; Laubenbacher, R; Li, Y

    2013-01-01

    The concept of a nested canalizing Boolean function has been studied over the course of the last decade in the context of understanding the regulatory logic of molecular interaction networks, such as gene regulatory networks. Such functions appear preferentially in published models of such networks. Recently, this concept has been generalized to include multi-state functions, and a recursive formula has been derived for their number, as a function of the number of variables. This paper carries out a detailed analysis of the class of nested canalizing functions over an arbitrary finite field. Furthermore, the paper generalizes the concept further, and derives a closed formula for the number of such generalized functions. The paper also derives a closed formula for the number of equivalence classes under permutation of variables. This is motivated by the fact that two nested canalizing functions that differ by a permutation of the variables share many important properties with each other. The paper contributes ...

  8. Spinal canal stenosis

    International Nuclear Information System (INIS)

    Spinal stenosis is a narrowing of the spinal canal by a combination of bone and soft tissues, which can lead to mechanical compression of spinal nerve roots or the dural sac. The lumbal spinal compression of these nerve roots can be symptomatic, resulting in weakness, reflex alterations, gait disturbances, bowel or bladder dysfunction, motor and sensory changes, radicular pain or atypical leg pain and neurogenic claudication. The anatomical presence of spinal canal stenosis is confirmed radiologically with computerized tomography, myelography or magnetic resonance imaging and play a decisive role in optimal patient-oriented therapy decision-making. (orig.)

  9. syndrome du canal carpien

    OpenAIRE

    boukraa, kheira; merniz, nacera

    2012-01-01

    Le canal carpien est la principale cause des acroparesthésies de la main. I La forme habituelle est la forme sensitive pure primitive de la femme en période I post ménopausique. Le traitement médical suffit le plus souvent. La constatation et l'installation de signes déficitaires neurologiques sont une indication à un traitement chirurgical. Le syndrome du canal carpien peut être un mode de début d'une polyarthrite u rhumatoïde.

  10. The evolutionary genetics of canalization.

    Science.gov (United States)

    Flatt, Thomas

    2005-09-01

    Evolutionary genetics has recently made enormous progress in understanding how genetic variation maps into phenotypic variation. However why some traits are phenotypically invariant despite apparent genetic and environmental changes has remained a major puzzle. In the 1940s, Conrad Hal Waddington coined the concept and term "canalization" to describe the robustness of phenotypes to perturbation; a similar concept was proposed by Waddington's contemporary Ivan Ivanovich Schmalhausen. This paper reviews what has been learned about canalization since Waddington. Canalization implies that a genotype's phenotype remains relatively invariant when individuals of a particular genotype are exposed to different environments (environmental canalization) or when individuals of the same single- or multilocus genotype differ in their genetic background (genetic canalization). Consequently, genetic canalization can be viewed as a particular kind of epistasis, and environmental canalization and phenotypic plasticity are two aspects of the same phenomenon. Canalization results in the accumulation of phenotypically cryptic genetic variation, which can be released after a "decanalizing" event. Thus, canalized genotypes maintain a cryptic potential for expressing particular phenotypes, which are only uncovered under particular decanalizing environmental or genetic conditions. Selection may then act on this newly released genetic variation. The accumulation of cryptic genetic variation by canalization may therefore increase evolvability at the population level by leading to phenotypic diversification under decanalizing conditions. On the other hand, under canalizing conditions, a major part of the segregating genetic variation may remain phenotypically cryptic; canalization may therefore, at least temporarily, constrain phenotypic evolution. Mechanistically, canalization can be understood in terms of transmission patterns, such as epistasis, pleiotropy, and genotype by environment

  11. Doscientos aos de Ciencias de la Tierra en la Argentina

    Directory of Open Access Journals (Sweden)

    Victor A. Ramos

    2011-09-01

    Full Text Available La historia de las Ciencias de la Tierra en la Argentina desde la Revolucin de Mayo muestra cuatro etapas diferentes relacionadas a cambios polticos mayores. El pasaje de una organizacin colonial controlada desde la metrpolis a un nuevo gobierno regional marc la necesidad imperiosa de fundar nuevas instituciones donde las bases de la ciencia pudieran ser impartidas. La etapa de las "Ciencias de Rivadavia" (1810-1830 represent un gran esfuerzo personal en esa direccin y aunque la mayor parte de sus iniciativas fracasaron, al menos dos instituciones por l creadas permanecen hasta el presente. La segunda etapa (1830-1853 estuvo dominada por los viajeros extranjeros, perodo en que personalidades como Alcide d'Orbigny y Charles Darwin llegaron al pas e hicieron contribuciones universales a las Ciencias de la Tierra basadas en observaciones locales que arrojaron luz en importantes procesos. La tercera etapa corresponde a la organizacin nacional (1853 hasta las primeras dcadas del siglo XX, cuando nuevas autoridades establecieron algn orden y promovieron la creacin de nuevas instituciones. La actitud proactiva hacia las ciencias bsicas de Juan Mara Gutirrez en la Universidad de Buenos Aires, tanto como las acciones del presidente Domingo F. Sarmiento para la Universidad de Crdoba, fueron la piedra fundamental para comenzar la investigacin y la enseanza de las Ciencias de la Tierra en la Argentina. Tan temprano como en 1865, con los primeros especialistas en Ciencias de la Tierra que vinieron de Italia, comenz la enseanza de la geologa en la Universidad de Buenos Aires, y unos pocos aos ms tarde los gelogos alemanes hicieron lo mismo en Crdoba. Estos dos hechos fundacionales consolidaron la cuarta etapa, cuando una serie de instituciones creadas en el siglo XX promueven el desarrollo presente de las Ciencias de la Tierra en todo el pas.

  12. Expression of intestinal transporter genes in beagle dogs

    OpenAIRE

    Cho, Soo-Min; Park, Sung-Won; Kim, Na-Hyun; Park, Jin-A; YI, HEE; CHO, Hee-Jung; PARK, KI-HWAN; HWANG, INGYUN; Shin, Ho-Chul

    2012-01-01

    This study was performed to produce a transcriptional database of the intestinal transporters of beagle dogs. Total RNA was isolated from the duodenum and the expression of various mRNAs was measured using GeneChip® oligonucleotide arrays. A total of 124 transporter genes were detected. Genes for fatty acid, peptide, amino acid and glucose and multidrug resistance/multidrug resistance-associated protein (MDR/MRP) transport were expressed at relatively higher levels than the other transporter ...

  13. Building networks and servers using BeagleBone

    CERN Document Server

    Pretty, Bill

    2015-01-01

    If you are a developer with BeagleBone experience and want to learn how to use it to set up a network and file server, then this book is ideal for you. To make the most of this book, you should be comfortable with the Linux operating system and know how to install software from the Internet, but you do not have to be a network guru.

  14. Absorption and pharmacokinetics of grapefruit flavanones in beagles

    OpenAIRE

    Mata Bilbao, María de Lourdes; Andrés Lacueva, Ma. Cristina; Roura, Elena; Jáuregui Pallarés, Olga; Escribano Ferrer, Elvira; Torre, Celina; Lamuela Raventós, Rosa Ma.

    2007-01-01

    The present study evaluated the pharmacokinetics of three different grapefruit flavanone forms in dog plasma and demonstrated their absorption after an oral intake of a grapefruit extract; pharmacokinetic parameters of these forms were also determined. Ten healthy beagles were administered 70 mg citrus flavonoids as a grapefruit extract contained in capsules, while two additional dogs were used as controls and given an excipient. The grapefruit flavanone naringin, along with its metabolites n...

  15. Atlas of experimentally-induced neoplasia in beagle dogs

    International Nuclear Information System (INIS)

    Beagle dogs have been utilized extensively in biomedical research. The US Department of Energy''s (DOE) Office of Health and Environmental Research (OHER) has sponsored life-span dose-effect radiation studies in beagles at various laboratories. Because results from studies in the various laboratories were to be compared, all the investigators strove to use similar nomenclature and criteria to describe biological effects. For this reason, pathologists from these laboratories met on five occasions between 1976 and 1977 to discuss nomenclature and histologic criteria for diagnoses. At these meeting, criteria were discussed for histopathologic description of lesions in bone, liver, lung, hematopoietic and lymphoid tissues, mammary gland, pituitary, testis, and thyroid. To provide further assurance of cooperation among the DOE laboratories involved, DOE organized several Task Groups in 1985, composed of staff members from the laboratories. The Task Group on Biological Effects was asked to standardize nomenclature and diagnostic criteria for pathology; this beagle pathology atlas is the result of that request. The atlas describes target organs of particular interest: lungs for radionuclides delivered by inhalation; bones for bone-seeking radionuclides; and hematopoietic and other soft tissues for external irradiation

  16. Atlas of experimentally-induced neoplasia in beagle dogs

    Energy Technology Data Exchange (ETDEWEB)

    Dagle, G.E.; Watson, C.R.

    1996-10-01

    Beagle dogs have been utilized extensively in biomedical research. The US Department of Energy`s (DOE) Office of Health and Environmental Research (OHER) has sponsored life-span dose-effect radiation studies in beagles at various laboratories. Because results from studies in the various laboratories were to be compared, all the investigators strove to use similar nomenclature and criteria to describe biological effects. For this reason, pathologists from these laboratories met on five occasions between 1976 and 1977 to discuss nomenclature and histologic criteria for diagnoses. At these meeting, criteria were discussed for histopathologic description of lesions in bone, liver, lung, hematopoietic and lymphoid tissues, mammary gland, pituitary, testis, and thyroid. To provide further assurance of cooperation among the DOE laboratories involved, DOE organized several Task Groups in 1985, composed of staff members from the laboratories. The Task Group on Biological Effects was asked to standardize nomenclature and diagnostic criteria for pathology; this beagle pathology atlas is the result of that request. The atlas describes target organs of particular interest: lungs for radionuclides delivered by inhalation; bones for bone-seeking radionuclides; and hematopoietic and other soft tissues for external irradiation.

  17. Root canal medicaments.

    Science.gov (United States)

    Kawashima, Nobuyuki; Wadachi, Reiko; Suda, Hideaki; Yeng, Thai; Parashos, Peter

    2009-02-01

    The ultimate goals of endodontic treatment are complete removal of bacteria, their byproducts and pulpal remnants from infected root canals and the complete seal of disinfected root canals. Intracanal medicaments have been thought an essential step in killing the bacteria in root canals; however, in modern endodontics, shaping and cleaning may be assuming greater importance than intracanal medicaments as a means of disinfecting root canals. Until recently, formocresol and its relatives were frequently used as intracanal medicaments, but it was pointed out that such bactericidal chemicals dressed in the canal distributed to the whole body from the root apex and so might induce various harmful effects including allergies. Furthermore, as these medicaments are potent carcinogenic agents, there is no indication for these chemicals in modern endodontic treatment. Today, biocompatibility and stability are essential properties for intracanal medicaments. The more modern meaning of intracanal dressing is for a blockade against coronal leakage from the gap between filling materials and cavity wall. Calcium hydroxide has been determined as suitable for use as an intracanal medicament as it is stable for long periods, harmless to the body, and bactericidal in a limited area. It also induces hard tissue formation and is effective for stopping inflammatory exudates. Single-visit endodontics, where intracanal medicaments are not used, is generally not now contraindicated and various reports have shown that the clinical outcomes between single- and multiple- visit endodontics are similar. There is no reason to counsel against single-visit endodontics: however, if multiple-visit endodontics is chosen, calcium hydroxide is recommended to be used as an intracanal medicament. PMID:19323305

  18. Curved canals: Ancestral files revisited

    Directory of Open Access Journals (Sweden)

    Jain Nidhi

    2008-01-01

    Full Text Available The aim of this article is to provide an insight into different techniques of cleaning and shaping of curved root canals with hand instruments. Although a plethora of root canal instruments like ProFile, ProTaper, LightSpeed ® etc dominate the current scenario, the inexpensive conventional root canal hand files such as K-files and flexible files can be used to get optimum results when handled meticulously. Special emphasis has been put on the modifications in biomechanical canal preparation in a variety of curved canal cases. This article compiles a series of clinical cases of root canals with curvatures in the middle and apical third and with S-shaped curvatures that were successfully completed by employing only conventional root canal hand instruments.

  19. Managing curved canals

    Directory of Open Access Journals (Sweden)

    Iram Ansari

    2012-01-01

    Full Text Available Dilaceration is the result of a developmental anomaly in which there has been an abrupt change in the axial inclination between the crown and the root of a tooth. Dilaceration can be seen in both the permanent and deciduous dentitions, and is more commonly found in posterior teeth and in maxilla. Periapical radiographs are the most appropriate way to diagnose the presence of root dilacerations. The controlled regularly tapered preparation of the curved canals is the ultimate challenge in endodontics. Careful and meticulous technique will yield a safe and sufficient enlargement of the curved canals. This article gives a review of the literature and three interesting case reports of root dilacerations.

  20. Estado, mercado de tierra urbana e inundaciones en ciudades argentinas

    Directory of Open Access Journals (Sweden)

    Clichevsky Nora

    2006-10-01

    Full Text Available En este trabajo se presentan los resultados de una investigación sobre las relaciones que se establecen entre los mercados de tierra urbana y las inundaciones en ciudades argentinas, en el marco más amplio de la vulnerabilidad urbana. Se pretende despejar incógnitas acerca del papel jugado por el Estado como regulador del mercado en áreas urbanas con vulnerabilidad natural a la inundación y como constructor de defensas contra las inundaciones y acerca de los impactos que han tenido las inundaciones y las obras de defensa contra ellas sobre el mercado de tierra y, por lo tanto, sobre el acceso al suelo urbano por parte de los distintos sectores de la población.

  1. Canal Wall Reconstruction Mastoidectomy

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective To investigate the advantages of canal wall reconstruction (CWR) mastoidectomy, a single-stage technique for cholesteatoma removal and posterior external canal wall reconstruction, over the open and closed procedures in terms of cholesteatoma recurrence. Methods: Between June 2002 and December 2005, 38 patients (40 ears) with cholesteatoma were admited to Sun Yat-Sen Memorial Hospital and received surgical treatments. Of these patients, 25 were male with ages ranging between 11 and 60 years (mean = 31.6 years) and 13 were female with ages ranging between 20 and 65 years (mean = 38.8 years). Canal wall reconstruction (CWR)mastoidectomy was performed in 31 ears and canal wall down (CWD) mastoidectomy in 9 ears. Concha cartilage was used for ear canal wall reconstruction in 22 of the 31 CWR procedures and cortical mastoid bone was used in the remaining 9 cases. Results At 0.5 to 4 years follow up, all but one patients remained free of signs of cholesteatoma recurrence, i.e., no retraction pocket or cholesteatoma matrix. One patient, a smoker, needed revision surgery due to cholesteatoma recurrence 1.5 year after the initial operation. The recurrence rate was therefore 3.2% (1/31). Cholesteatoma recurrence was monitored using postoperative CT scans whenever possible. In the case that needed a revision procedure, a retraction pocket was identified by otoendoscopy in the pars flacida area that eventually evolved into a cholesteatoma. A pocket extending to the epitympanum filled with cholesteatoma matrix was confirmed during the revision operation, A decision to perform a modified mastoidectomy was made as the patient refused to quit smoking. The mean air-bone gap in pure tone threshold was 45 dB before surgery and 25 dB after (p < 0.05). There was no difference between using concha cartilage and cortical mastoid bone for the reconstruction regarding air-bone gap improvement, CT findings and otoendoscopic results. Conclusion CWR mastoidectomy can be used for

  2. Saber tradicional, ética de la tierra y sustentabilidad

    Directory of Open Access Journals (Sweden)

    Heyd, Thomas

    2005-06-01

    Full Text Available This is the crucial moment to take on sustainable forms of life, and hence it is now of primary importance to adopt a land ethic that takes into account not only the use value but also the intrinsic value of the beings that make up our natural environment. In this essay I begin by focusing on the obstacles that the development of a land ethic has to face, obstacles that are due to limitations in knowledge and to mistaken assumptions. As a way to resolve these practical difficulties I first point out the existence of our natural inclinations toward the land and life. Furthermore, I propose that the traditional knowledge of those peoples that have lived for extended periods with their environments can serve us as models for the development of a culture of appreciation for the earth and its inhabitants.

    Éste ese! momento crucial para emprender formas de vida sustentables, por lo que resulta esencial adoptar una ética de la tierra que reconozca el valor intrínseco además del valor útil de los seres que pueblan nuestro medio ambiente natural. En este ensayo empiezo enfocando los obstáculos a que se enfrenta el desarrollo de una ética de la tierra, obstáculos que resultan ser el producto de conocimientos limitados y suposiciones equivocadas. En resolución de esas problemáticas prácticas apunto, primero, la existencia de inclinaciones naturales hacia la tierra y la vida. Además propongo que en el saber tradicional de los pueblos que han convivido mucho tiempo con sus espacios tenemos modelos de formas del conocer que nos pueden servir de modelo para llegar a desarrollar una cultura de aprecio de la tierra y de sus habitantes.

  3. Microstratigraphy of shell middens of Tierra del Fuego

    OpenAIRE

    Vila i Mitjà, Assumpció; Barceló, Juan A.

    2006-01-01

    The results of the joint research of Spanish and Argentinean teams since 1986 on shell middens of Tierra del Fuego can be useful guidelines for excavating and explaining similar archaeological sites around the world. We assume that human activity is organized in space and time and, as a consequence the random, non-random or homogeneous structure the resulting archaeological evidence has to be demonstrated before assuming a palimpsest nature of the deposit. We show the possibilities and releva...

  4. Analysis of sedimentation of canals

    Directory of Open Access Journals (Sweden)

    Agunwamba, J.C.,

    2013-03-01

    Full Text Available The dredged canals in the Niger Delta coastal flood plain are being threatened by siltation. This study is limited to those canals in Rivers State of Nigeria, which are under the influence of tidal waves. A total of eight canals were considered with four each from Ekulama and Cawthorne Channel. Different approaches were used to carry out this study, which includes field reconnaissance survey, hydrographic survey, soil sample analysis and collection of all available data and information. The typical bed materials size (D50 is approximately 0.01mm; which gives a settling velocity of 0.09mm/sec using stroke’s law. Hydrographic survey of the canals from 1992 to 1996 revealed an average siltation rate of 2.35m/yr. A regression equation was also derived which relates the cost of dredging to canal area, rate of siltation and average aggregation. A plot of canal centre profile; entrance, middle and end cross sections showing sediment distribution along the canal profile, shows that majority of the particles that form the sediment enter the canal from the rivers. The sedimentation is caused by the reduction in water current, which has average value of 0.0145m/sec. The bathyorographical check on the canals revealed that the sum of the two exterior angles of the canal with the river at the point of connection has to lie within 1800 + 50 for an effective flow that will minimize settlement of particles. In addition, the canals should be constructed to start and terminate on a moving water body, to avoid dead ends. A regression equation was determined which relates the cost of dredging to canal area, rate of siltation and average aggradations.

  5. Pulmonary lesions induced by inhaled plutonium in beagles

    International Nuclear Information System (INIS)

    The histopathologic features of pulmonary fibrosis and bronchiolo-alveolar carcinoma in beagles exposed to aerosols of 238Pu or 239Pu oxide are reviewed. A hypothesis of the pathogenesis of radiation pneumonitis induced by inhalation of plutonium oxide is presented; this hypothesis included phagocytosis of Pu particles, fibrosis responding to the necrosis, and alveolar cell hyperplasia compensating for alveolar cells killed by alpha radiation. Histopathologic features of the epithelial changes suggest a progression from hyperplasia to metaplasia and, finally, to bronchiolo-alveolar carcinoma. The possibility of concurrent radiation-induced lymphopenia contributing to the development of bronchiolo-alveolar carcinoma through a loss of immunologic surveillance is discussed

  6. Pulmonary lesions induced by inhaled plutonium in beagles

    International Nuclear Information System (INIS)

    The histopathologic features of pulmonary fibrosis and bronchiolo-alveolar carcinoma in beagles exposed to aerosols of plutonium oxide were reviewed. A hypothesis of the pathogenesis of radiation pneumonitis induced by inhalation of plutonium oxide was presented; this hypothesis included phagocytosis of plutonium particles, fibrosis responding to the necrosis, and alveolar cell hyperplasia compensating for alveolar cells killed by alpha radiation. Histopathologic features of the epithelial changes suggest a progression from hyperplasia to metaplasia and, finally, to bronchiolo-alveolar carcinoma. The possibility of concurrent radiation-induced lymphopenia contributing to the development of bronchiolo-alveolar carcinoma through a loss of immunologic surveillance was discussed

  7. Hematological effects of inhaled plutonium dioxide in beagles

    International Nuclear Information System (INIS)

    A life-span study indicated that plutonium activity in the thoracic lymph nodes is a contributor to development of lymphopenia in beagles exposed to 239PuO2. Significant lymphopenia was found in 67 (58%) beagles given a single nose-only exposure to 239PuO2 to result in mean initial lung depositions ranging from 0.69 to 213.3 kBq. Lymphoid atrophy and sclerosis of the thoracic lymph nodes and lymphopenia were observed in exposure-level groups with initial lung depositions ≥2.5 kBq. Those dogs with final plutonium concentrations in the thoracic lymph nodes ≥0.4 kBq/g and dose rates ≥0.01 Gy/day developed lymphopenia. Marked differences existed between chronically lymphopenic dogs and intermittently lymphopenic dogs with regard to initial lung deposition, time to lymphopenic events and absolute lymphocyte concentrations. Linear regression analysis revealed moderate correlation between reduction in lymphocyte values and initial lung deposition, in both magnitude and time of appearance after exposure. Cumulative dose and dose rate appeared to act together to produce initial effects on lymphocyte populations, while dose rate alone appeared to be responsible for the maintenance and subsequent cycles of lymphopenia seen over the life span. No primary tumors were associated with the thoracic lymph nodes in this study, although 70% of the lymphopenic dogs developed lung tumors. 28 refs., 2 figs., 7 tabs

  8. Beagle 2: The Next Exobiology Mission to Mars

    Science.gov (United States)

    Gibson, Everett K., Jr.; Pillinger, Colin T.; Wright, Ian P.; Morse, Andy; Stewart, Jenny; Morgan, G.; Praine, Ian; Leigh, Dennis; Sims, Mark R.

    2001-01-01

    Beagle 2 is a 60 kg probe (with a 30 kg lander) developed in the United Kingdom for inclusion on the European Space Agency's 2003 Mars Express. Beagle 2 will deliver to the Martian surface a payload which consists of a high percentage of science instruments to landed spacecraft mass. Beagle 2 will be launched in June, 2003 with Mars Express on a Soyuz-Fregat rocket from the Baikonur Cosmodrome in Kazakhstan. Beagle 2 will land on Mars on December 26, 2003 in the Isidis Planitia basin (approximately 10 degrees N and 275 degrees W), a large sedimentary basin that overlies the boundary between ancient highlands and northern plains. Isidis Planitia, the third largest basin on Mars, which is possibly filled with sediment deposited at the bottom of long-standing lakes or seas, offers an ideal environment for preserving traces of life. Beagle 2 was developed to search for organic material and other volatiles on and below the surface of Mars in addition to the study of the inorganic chemistry and mineralogy. Beagle 2 will utilize a mechanical mole and grinder to obtain samples from below the surface, under rocks and inside rocks. A pair of stereo cameras will image the landing site along with a microscope for examination of surface and rock samples. Analyses will include both rock and soil samples at various wavelengths, X-ray spectrometer and Mossbauer spectrometer as well as a search for organics and other light element species (e.g. carbonates and water) and measurement of their isotopic compositions. Beagle 2 has as its focus the goal of establishing whether evidence for life existed in the past on Mars at the Isidis Planitia site or at least establishing if the conditions were ever suitable. Carbonates and organic components were first recognized as existing on Mars when they were found in the Martian meteorite Nakhla. Romanek et al showed the carbonates in ALH84001 were formed at low temperatures. McKay et al noted possible evidence of early life on Mars within the

  9. Modelling and interpreting spectral energy distributions of galaxies with BEAGLE

    CERN Document Server

    Chevallard, Jacopo

    2016-01-01

    We present a new-generation tool to model and interpret spectral energy distributions (SEDs) of galaxies, which incorporates in a consistent way the production of radiation and its transfer through the interstellar and intergalactic media. This flexible tool, named BEAGLE (for BayEsian Analysis of GaLaxy sEds), allows one to build mock galaxy catalogues as well as to interpret in terms of physical parameters any combination of photometric and spectroscopic galaxy observations. The current version of the tool includes the versatile modeling of the emission from stars and photoionized gas, attenuation by dust and the accounting for different instrumental effects. We show a first application of the BEAGLE tool to the interpretation of broadband SEDs of a published sample of ${\\sim}10^4$ galaxies at redshifts $0.1 \\lesssim z\\lesssim8$. We find that the constraints derived on photometric redshifts using this multi-purpose tool are comparable to those obtained using public, dedicated photometric-redshift codes and ...

  10. Planetary Protection for the Beagle2 Mars Lander Mission

    Science.gov (United States)

    Spry, J. A.; Pillinger, J. M.; Pillinger, C. T.

    Following ejection from the Mars Express orbiter on 19th December 2003, the Beagle 2 probe of mass 68kg headed for the martian surface. The fact that no communications were established with the Beagle 2 lander, and thus neither its location nor fate are currently known, heightens the relevance of the planetary protection aspects of the project. Payload configuration requirements and stringent mass constraints in the design did not allow the whole spacecraft to be terminally sterilised by a single processing method, due to material incompatibility issues. The lander was therefore integrated aseptically in a specially designed and constructed Class 10 cleanroom facility, following appropriate sterilisation processing at sub-assembly level utilising one of several different sterilisation technologies. Additional further cleanliness precautions were taken to ensure the integrity of the science package. The project demonstrates that the COSPAR requirements for a category IVA mission can be met or exceeded using this approach. The data show that, even in the event of a non-nominal landing, the martian environment is protected through the precautionary and conservative approach adopted in the planetary protection strategy.

  11. Spinal canal stenosis; Spinalkanalstenose

    Energy Technology Data Exchange (ETDEWEB)

    Papanagiotou, P.; Boutchakova, M. [Klinikum Bremen-Mitte/Bremen-Ost, Klinik fuer Diagnostische und Interventionelle Neuroradiologie, Bremen (Germany)

    2014-11-15

    Spinal stenosis is a narrowing of the spinal canal by a combination of bone and soft tissues, which can lead to mechanical compression of spinal nerve roots or the dural sac. The lumbal spinal compression of these nerve roots can be symptomatic, resulting in weakness, reflex alterations, gait disturbances, bowel or bladder dysfunction, motor and sensory changes, radicular pain or atypical leg pain and neurogenic claudication. The anatomical presence of spinal canal stenosis is confirmed radiologically with computerized tomography, myelography or magnetic resonance imaging and play a decisive role in optimal patient-oriented therapy decision-making. (orig.) [German] Die Spinalkanalstenose ist eine umschriebene, knoechern-ligamentaer bedingte Einengung des Spinalkanals, die zur Kompression der Nervenwurzeln oder des Duralsacks fuehren kann. Die lumbale Spinalkanalstenose manifestiert sich klinisch als Komplex aus Rueckenschmerzen sowie sensiblen und motorischen neurologischen Ausfaellen, die in der Regel belastungsabhaengig sind (Claudicatio spinalis). Die bildgebende Diagnostik mittels Magnetresonanztomographie, Computertomographie und Myelographie spielt eine entscheidende Rolle bei der optimalen patientenbezogenen Therapieentscheidung. (orig.)

  12. The Beagle 2 Effect - public response to the UK Mars lander

    Science.gov (United States)

    Pillinger, J. M.; Pillinger, C. T.

    As a prerequisite for understanding science, the target audience must first be aware of an issue and then continue to maintain interest. We discuss the impact of the Beagle 2 mission to Mars on raising awareness amongst the general public as the first step to increasing understanding of the scientific and technological challenges and solutions such a mission addresses. The massive amount of public interest created is now being ttributed to the so-called "Beagle 2 Effect". We consider the reasons why the public, particularly, but not exclusively, in the UK took Beagle 2 to heart. Initially our strategy, as part of the PR plan for Beagle 2, was to collate media coverage for various stages and discrete campaigns in particular to use press cuttings to determine the level of recognition of Beagle 2 as a brand. At the start of the project this information was to support sponsorship bids, latterly the intrinsic value of media, and hence public, awareness was recognised by the major partners in the project. Much of the subsequent public awareness resulted from the comprehensive coverage in all branches of the media. A second opportunity to evaluate the response to the mission was presented to us as it became increasingly clear that Beagle 2 was able to engage an audience much wider than that typically interested in space, or science in general. We highlighted how far mention of Beagle 2 has spread. Additionally numerous unsolicited letters have been received from the public and these have been collated to indicate the factors which appear to have contributed to the widespread interest in Beagle 2. It is not clear whether the "Beagle 2 Effect" can, or will, be transferred to subsequent space missions.

  13. Exploraciones Micológicas en Tierra del Fuego Mycological explorations in Tierra del Fuego

    Directory of Open Access Journals (Sweden)

    Irma J. Gamundí

    2007-07-01

    Full Text Available Se narran las expediciones marítimas y terrestres en Tierra del Fuego durante los siglos XIX y XX, desde el punto de vista de la exploración micológica cuyos resultados han sido vertidos en publicaciones, destacando las expediciones argentinas. Contiene mapas con las principales expediciones argentinas. Se hace una evaluación de la diversidad fúngica de acuerdo con los datos previamente analizados, comparando los registros de colección en ambos períodos que indican una duplicación del número total de taxones de 647 especies descriptas en el siglo XIX hasta 1269 en el siglo XX. Simultáneamente se observa una disminución del 50,4 % al 19.7 % en el número de especies nuevas publicadas. Se agrega una lista de coleccionistas y otra del estado de conservación ex situ de especies seleccionadas. Se hace un breve comentario sobre la conservación de hábitats colonizados por hongos que están perturbados por la explotación no sustentable de los recursos naturales.A narration of the leading maritime and terrestrial expeditions in Fuegia during the XIX and XX centuries is approached from the point of view of the mycological exploration and published results on the mycobiota, emphazising the Argentine expeditions. Maps with the itinerary of main Argentine expeditions is given. An evaluation of the fungal diversity according to the previous review is presented, comparing the fungal records during both periods that shows duplication of the total number of taxa from 647 species described in XIX century to 1269 in the XX century. Simultaneously there is a decrease from 50.4 % to 19.7 % in the number of new species published. A list of collectors and a table with the state of ex-situ conservation of selected species is presented. A brief comment is given on conservation of habitats supporting fungal population that are disturbed by unsustainable exploitation of natural resources.

  14. Construcción con tierra en el siglo XXI

    Directory of Open Access Journals (Sweden)

    Bestraten, S.

    2011-09-01

    Full Text Available Earthen construction during the 21rst century first decade has resurfaced worldwide as a sustainable, low environmental impact and great expressive material. The research and the number of projects has been increased related to the growth of the associations, institutions, universities and events surrounding this sector. These projects have managed to modernize the traditional techniques of building with earth in order to adapt them to today’s projecting needs, and have been widely recognized for its quality. The aim of this article is to provide a global view on earth construction internationally, providing technical data of its utilization in contemporary architectural projects.

    La construcción con tierra durante la primera década del siglo XXI ha resurgido en todo el mundo como un material con propiedades sostenibles, de bajo impacto ambiental y de gran capacidad expresiva. Se ha experimentado un crecimiento a nivel de proyectos e investigaciones sobre el material relacionado con el aumento de número de asociaciones, instituciones, universidades y eventos alrededor de este sector. Los proyectos actuales han sabido modernizar las técnicas tradicionales de construcción con tierra para adaptarlas a las necesidades proyectuales y constructivas, siendo ampliamente reconocidos por su calidad. El objetivo de este artículo es ofrecer una visión actual sobre la construcción con tierra a nivel internacional, aportando datos técnicos de su utilización en proyectos arquitectónicos contemporáneos.

  15. LUCHA POR LA TIERRA EN EL NORTE DE URUGUAY

    Directory of Open Access Journals (Sweden)

    Gabriel Oyhantçabal Benelli

    2011-12-01

    Full Text Available Este artículo analiza la trayectoria de la lucha por la tierra en Bella Unión, una región característica en Uruguay por la producción de caña de azúcar, a través de los movimientos de clase de sus principales protagonistas: los cortadores de caña sindicalizados en la Unión de Trabajadores Azucareros de Artigas (UTAA. El recorrido histórico hace énfasis en dos períodos históricos diferentes: 1961-1973 y 2005-presente. El primero va desde la fundación del sindicato hasta el golpe militar. Se da en un contexto de auge de la lucha de masas en Uruguay en el cual los trabajadores rurales se organizan en la UTAA levantando, entre otras, la bandera de la Reforma Agraria. El segundo período está marcado por la llegada al gobierno nacional del Frente Amplio, una coalición social-demócrata que reactiva la producción de caña de azúcar en Bella Unión. Este cambio supone una oportunidad para las luchas sociales que la UTAA aprovecha con ocupaciones de tierra favoreciendo un proceso de colonización para los trabajadores rurales. Sin embargo el acceso a la tierra genera nuevas contradicciones, y por tanto nuevos desafíos, por los cambios en la forma de subsunción del trabajo al capital.

  16. Sol, Tierra y Luna. Movimientos relativos y sus consecuencias

    OpenAIRE

    Cardenete García, Sebastián

    2011-01-01

    Cuando se pregunta a los estudiantes por la causa de las estaciones suelen responder: “en verano estamos más próximos al Sol y en invierno estamos más lejos del Sol”. La persistencia de esta idea y el hecho de su generalización entre los estudiantes y muchos adultos me ha inducido a escribir este artículo, en el cual se trata de explicar, de una forma clara y simple, el motivo de este y otros fenómenos debidos al movimiento de la Luna alrededor de la Tierra y de ésta alrededor del Sol....

  17. The peat bogs of Tierra del Fuego, Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Rabassa, J.; Coronato, A. [Centro Austral de Investigaciones Cientificas, Ushuaia (Argentina); Roig, C. [Universidad Nacional de la Patagonia, Ushuaia (Argentina). Catedra de Geograffa Fisica

    1996-12-31

    The peat bogs and peat deposits of Argentina are briefly described, with emphasis on the island of Tierra del Fuego, where the vast majority of the bogs are concentrated, due to environmental and climatic conditions. The Fuegian bogs are a source of peaty materials, presently used in soil-improving techniques. Further studies are needed to establish other technological possibilities. From the scientific point of view, the Fuegian bogs are outstanding palaeoclimatic and palaeoenvironmental data banks, due to their uninterrupted continuity since Late Glacial times and their exceptional pollen record and subfossil wood remains. (orig.) (9 refs.)

  18. Colonización y tierras públicas

    OpenAIRE

    Dios, Flavio Fernando de

    2013-01-01

    Desde la época colonial, el problema agrario ocupo un lugar central entre las preocupaciones de políticos e intelectuales. Dentro de él, la cuestión de la propiedad de la tierra emergía como uno de los principales problemas a resolver. Fundamentalmente su distribución. Pero de nada valieron los certeros diagnósticos que se hicieron sobre la realidad pampeana, extensa llanura, que contenía una potencial riqueza agraria, pero que estaba despoblada. Posteriormente acaparada en pocas manos gen...

  19. Wedge Structures in Southernmost Argentina (Rio Grande, Tierra del Fuego)

    OpenAIRE

    Pérez Alberti, Augusto; Coronato, Andrea; Costa-Casais, Manuela; Valcarcel-Díaz, Marcos

    2008-01-01

    [EN] Wedge-like structures occur in raised beach gravels near Rio Grande, eastern Tierra Del Fuego (latitude 53°50′S; longitude 67°5′W). They vary in dimension, being approximately 1.0–1.5 m deep and 0.3–0.8 m in apparent width. Some are closely spaced, while others are as much as 5.0–8.0 m apart. The infill is predominantly fine and coarse sand, together with silt, all of local provenance. There is little evidence of secondary infill. It is unclear whether these structures are soil wedges, s...

  20. Hood Canal Steelhead - Hood Canal Steelhead Supplementation Experiment

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Hood Canal Steelhead Project is a 17-year before-after-control-impact experiment that tests the effects of supplementation on natural steelhead populations in...

  1. Method for Constructing Standardized Simulated Root Canals.

    Science.gov (United States)

    Schulz-Bongert, Udo; Weine, Franklin S.

    1990-01-01

    The construction of visual and manipulative aids, clear resin blocks with root-canal-like spaces, for simulation of root canals is explained. Time, materials, and techniques are discussed. The method allows for comparison of canals, creation of any configuration of canals, and easy presentation during instruction. (MSE)

  2. Toxicity of inhaled 91YCl3 in Beagle dogs. XVII

    International Nuclear Information System (INIS)

    The metabolism, dosimetry, and biological effects of inhaled 91YCl3 in Beagle dogs are being studied. Forty-two dogs with initial 91Y body burdens from 14 to 1300 μCi/kg body weight and 12 control dogs were observed during their life spans. Four additional dogs with a mean initial body burden of 180 μCi 91Y/kg body weight were placed in a sacrifice study. All 46 of the exposed dogs and all 12 of the control dogs have died. Dogs with the highest initial body burdens died with bone marrow damage and pancytopenia. Three dogs died with nasal cavity carcinomas, three died with pulmonary carcinomas, and one died with hepatic hemangiosarcoma. These cancers all appeared to be related to radiation injury. Control dogs died of miscellaneous neoplastic and chronic diseases

  3. Toxicity of inhaled 91YCl3 in beagle dogs

    International Nuclear Information System (INIS)

    The metabolism, dosimetry and effects of inhaled 91YCl3 in beagle dogs are being studied. Forty-two dogs with 91Y initial body burdens from 14 to 1300 μCi/kg body weight and 12 control dogs are being maintained for lifetime observation. Four additional dogs with a mean initial body burden of 180 μCi/kg body weight were placed in a sacrifice study. Thirty-six of the exposed dogs and 7 of the control dogs have died. Dogs with the highest activity levels died with bone marrow damage and pancytopenia. Three dogs died with nasal cavity carcinomas and three with pulmonary carcinomas and one with hepatic hemangiosarcoma that all appear related to radiation injury. Control dogs died of miscellaneous neoplastic and chronic diseases. Observations are continuing on 10 surviving exposed dogs and six surviving unexposed dogs

  4. Toxicity of inhaled 91YCl3 in Beagle dogs. XVI

    International Nuclear Information System (INIS)

    The metabolism, dosimetry and biological effects of inhaled 91YCl3 in Beagle dogs are being studied. Forty-two dogs with initial 90Y body burdens from 14 to 1300 μCi per kilogram body weight and 12 control dogs are being maintained for lifetime observation. Four additional dogs with a mean initial body burden of 180 μCi 91Y per kilogram body weight were placed in a sacrifice study. Forty-four of the exposed dogs and all 12 of the control dogs have died. Dogs with the highest initial body burdens died with bone marrow damage and pancytopenia. Three dogs died with nasal cavity carcinomas, three dogs died with pulmonary carcinomas and one dog died with hepatic hemangiosarcoma; these cancers all appeared to be related to radiation injury. Control dogs died of miscellaneous neoplastic and chronic diseases. Observations are continuing on the two surviving exposed dogs

  5. Dose-effect studies with inhaled plutonium oxide in beagles

    International Nuclear Information System (INIS)

    Beagle dogs given single exposure to 239PuO2 or 238Pu16O2 aerosols are being observed for life-span dose-effect relationships. The 239Pu body burden of the nine dogs dying due to respiratory insufficiency during the first 3 years after exposure was 1 to 12 μCi. One of these dogs had a pulmonary tumor. None of the dogs exposed to 238Pu died during the first postexposure year. After inhalation of 239PuO2 or 238PuO2 lymphocytopenia was the earliest observed effect, occurring 0.5 to 2 years after deposition of greater than or equal to 80 nCi plutonium in the lungs. (U.S.)

  6. Dose-effect studies with inhaled plutonium oxide in beagles

    International Nuclear Information System (INIS)

    Beagle dogs given a single exposure to 239PuO2 or 238PuO2 aerosols are being observed for life-span dose-effect relationships. The 239Pu body burden of the nine dogs that died of pulmonary fibrosis-induced respiratory insufficiency during the first 3 yr after exposure was 1 to 12 μCi. One of these dogs had a pulmonary tumor. Five additional dogs with body burdens of 0.7 to 1.8 μCi died due to pulmonary neoplasia 3 to 5 yr after exposure. None of the dogs exposed to 238Pu have died during the first 3 postexposure yr. Lymphocytopenia was the earliest observed effect after inhalation of 239PuO2 or 238PuO2, occurring 0.5 to 2 yr after deposition of greater than or equal to 80 nCi plutonium in the lungs

  7. Dose-effect studies with inhaled plutonium oxide in beagles

    International Nuclear Information System (INIS)

    Beagle dogs given single exposure to 239PuO2 or 238PuO2 aerosols are being observed for life-span dose-effect relationships. The 239Pu body burden of the nine dogs dying due to pulmonary fibrosis-induced insufficiency during the first 3 years after exposure was 1 to 12 μCi. One of these dogs had a pulmonary tumor. Three additional dogs with body burdens of 0.7 to 1.8 μCi died due to pulmonary neoplasia 4-1/2 years after exposure. None of the dogs exposed to 238Pu have died during the first two postexposure years. After inhalation of 239PuO2 or 238PuO2 lymphocytopenia was the earliest observed effect, occuring 0.5 to 2 years after deposition of greater than or equal to 80 nCi plutonium in the lungs

  8. Radium-226-induced dental disease in Beagles: a radiographic study

    International Nuclear Information System (INIS)

    Evaluation of dental radiographs made at necropsy and during the life of the dogs clearly shows age dependent changes within the control dogs. Periodontal diseases, loss of lamina dura, root ankylosis, and loss of pulp cavity were all commonly noted. Tooth loss and dental caries were rare in the control dogs. In injected Beagles loss of lamina dura was noted earlier and was dose dependent. Tooth loss and dental carried increased with dose level and appeared earlier. Tooth loss was common by 1600-1800 days of age while dental caries were common in almost all dogs by 1600-1800 days of age in the R40 level. Dental caries was the most accurate indication of the level of 226Ra toxicity. 18 reference, 1 table

  9. Pathology in a lifespan study of x-irradiated female beagles

    International Nuclear Information System (INIS)

    Clinical records, gross necropsy records, slides, and stored tissues of x-irradiated beagles were reviewed. Tables are presented to show preliminary determinations of causes of death, neoplasms found, and number of dogs at risk in relation to age and dose level. Mammary and ovarian tumors were more numerous in irradiated beagles and were partially responsible for shortening of lifespan. Neoplasms of the urogenital system were also increased in irradiated groups

  10. Restricted dog leucocyte antigen (DLA) class II haplotypes and genotypes in Beagles

    OpenAIRE

    Soutter, Francesca; Kennedy, Lorna J; Ollier, William E R; Solano-Gallego, Laia; Catchpole, Brian

    2015-01-01

    Beagles are commonly used in vaccine trials as part of the regulatory approval process. Genetic restriction within this breed and the impact this might have on vaccine responses are rarely considered. This study was designed to characterise diversity of dog leucocyte antigen (DLA) class II genes in a breeding colony of laboratory Beagles, whose offspring are used in vaccine studies. DLA haplotypes were determined by PCR and sequence-based typing from genomic DNA extracted from blood. Breeding...

  11. Carcinogenesis of inhaled radio daughters with uranium ore dust in beagle dogs

    International Nuclear Information System (INIS)

    Daily exposures of adult beagle dogs to inhaled radon daughters and to uranium ore dust for 4-1/2 to 6 yr have produced respiratory tract carcinomas, at similar cumulative working level months (WLM) of exposures to those which induced carcinomas in uranium miners. Biological data from the beagle-dog experiments can therefore be used for prediction of carcinogenic risk under changing exposure conditions in future uranium miners

  12. Radium-induced dental changes in humans and beagles: a comparative microradiographic study

    International Nuclear Information System (INIS)

    Microradiographs made from thin sections of teeth of humans carrying skeletal deposits of 226Ra and 228Ra and of beagles injected with 226Ra showed similar patterns of change with age. The patterns consisted of the presence of remodeling units of alveolar bone that extended across the gomphosis and involved the cementum and dentine. This is not described as a normal aging change in humans or beagles. 3 tables

  13. Tissue reactions to suture materials in the oral mucosa of beagle dogs

    OpenAIRE

    Kim, Jae-Seok; Shin, Seung-Il; Herr, Yeek; Park, Joon-Bong; Kwon, Young-Hyuk; Chung, Jong-Hyuk

    2011-01-01

    Purpose The objective of this study was to compare and evaluate the inflammatory responses of three widely used suture materials in the keratinized gingiva and buccal mucosa of beagle dogs. Methods Silk, polyglycolic acid, and nylon sutures were placed within the mandibular keratinized gingiva and maxillary buccal mucosa of four male beagle dogs. Biopsies were taken 3, 7, and 14 days after suturing. Specimens were prepared with hematoxylin-eosin stain for evaluation under a light microscope. ...

  14. 226Ra-induced dental changes: a comparative microradiographic study of human and beagle dog

    International Nuclear Information System (INIS)

    Comparison of microradiographs made from thin sections of teeth from human and the Beagle dog show a similar pattern of change dependent on age of exposure and duration of exposure prior to death or extraction. The pattern of change consisted of the presence of remodeling units of alveolar bone that extended across the gomphosis and involved the cementum and dentine. This pattern of change is not described as a normal aging change in either humans or the Beagle dog. 2 tables

  15. Consideration of age-dependent radium retention in people on the basis of the beagle model

    International Nuclear Information System (INIS)

    Skeletal calcification as a function of age has been estimated for human females on the basis of the beagle model. The interspecies scaling of radium retention characteristics has been described in terms of skeletal calcium addition rates for beagles and humans. radium retention in humans exposed to less than 200 μCi was greatest in individuals who were less than 18 years old when exposed

  16. Ultrasonic cleaning of root canals

    Science.gov (United States)

    Verhaagen, Bram; Boutsioukis, Christos; Jiang, Lei-Meng; Macedo, Ricardo; van der Sluis, Luc; Versluis, Michel

    2011-11-01

    A crucial step during a dental root canal treatment is irrigation, where an antimicrobial fluid is injected into the root canal system to eradicate all bacteria. Agitation of the fluid using an ultrasonically vibrating miniature file has shown significant improvement in cleaning efficacy over conventional syringe irrigation. However, the physical mechanisms underlying the cleaning process, being acoustic streaming, cavitation or chemical activity, and combinations thereof, are not fully understood. High-speed imaging allows us to visualize the flow pattern and cavitation in a root canal model at microscopic scales, at timescales relevant to the cleaning processes (microseconds). MicroPIV measurements of the induced acoustic streaming are coupled to the oscillation characteristics of the file as simulated numerically and measured with a laser vibrometer. The results give new insight into the role of acoustic streaming and the importance of the confinement for the cleaning of root canals.

  17. Mandibular first molar with three distal canals

    OpenAIRE

    Shweta Jain

    2011-01-01

    With the increasing number of reports of aberrant root canal morphology, the clinician needs to be aware of the variable anatomy. Various case reports have been published with the finding of middle mesial canal in mandibular first molar, however finding of middle distal canal in distal root of mandibular first molar is rare. This case report describes root canal treatment of two rooted mandibular first molar with five root canals (three in distal and two in mesial root), and Sert and Bayirli ...

  18. Tierra y familia en la España meridional, siglos XIII-XIX.

    OpenAIRE

    Igor Goicovic Donoso

    2011-01-01

    Las siete contribuciones recopiladas por Francisco García Gon-zález en el texto Tierra y familia en la España meridional, siglos XIII-XIX, nos sitúan frente a la historia social a partir de dos inflexiones epistemológicas íntimamente relacionadas en la historia: tierra y familia. Efectivamente, la diada tierra-familia, durante el Antiguo Régimen europeo, se convirtió en un factor explicativo de buena parte de los procesos de articulación de la sociedad. Así, la relación de los sujetos co...

  19. Periodismo ambiental en Canal Sur Televisión

    Directory of Open Access Journals (Sweden)

    Lic. Miguel Montaño Montaño

    1999-01-01

    Full Text Available El autor estudia el origen histórico del periodismo ambiental, la evolución en España y Andalucía y su aparición en Canal Sur TV Realiza un análisis sobre la información medioambiental, especialidad del periodismo que en la década de los noventa despierta nuevamente gran interés entre el público. La televisión autonómica ha dedicado, desde su creación numerosos programas sobre el medio ambiente. Actualmente sus Servicios Informativos tienen la sección Medio Ambiente. De la importancia que se concede a este tipo de información es un buen ejemplo el programa «Tierra y Mar», que incorpora progresivamente noticias medioambientales, referidas a la educación ambiental, el mantenimiento y recuperación de la biodiversidad y la presentación de modelos de conducta respetuosos.

  20. LUCHA POR LA TIERRA EN EL NORTE DE URUGUAY

    OpenAIRE

    Gabriel Oyhantçabal Benelli; Matías Carámbula Pareja

    2011-01-01

    Este artículo analiza la trayectoria de la lucha por la tierra en Bella Unión, una región característica en Uruguay por la producción de caña de azúcar, a través de los movimientos de clase de sus principales protagonistas: los cortadores de caña sindicalizados en la Unión de Trabajadores Azucareros de Artigas (UTAA). El recorrido histórico hace énfasis en dos períodos históricos diferentes: 1961-1973 y 2005-presente. El primero va desde la fundación del sindicato hasta el golpe militar. Se d...

  1. Phytoseiid mites (Acari: Phytoseiidae) from Patagonia and Tierra del Fuego.

    Science.gov (United States)

    Ferragut, Francisco; Navia, Denise

    2015-01-01

    Predatory phytoseiid mites have been intensively studied and surveyed in the last decades because of their economic importance as biocontrol agents of agricultural pests. However, many regions of the world remain unexplored and the diversity of the family worldwide is still fragmentary. Up to date no phytoseiid species have been collected in the southernmost part of the Earth down to latitude 45º S. In this study Phytoseiidae were sampled from native vegetation in southern Argentina and Chile in the regions of Patagonia and Tierra del Fuego Island. Thirteen species were collected, five of which were previously described and eight, Chileseius australis n. sp., Neoseiulus mapuche n. sp., Typhlodromips valdivianus n. sp., T. fissuratus n. sp., Amblyseius grandiporus n. sp., A. caliginosus n. sp., Typhlodromus (Anthoseius) anomalos n. sp. and Metaseiulus parabrevicollis n. sp. are proposed as new to science and are described and diagnosed. PMID:26250248

  2. The subantartic Nothofagus forests of Tierra del Fuego: distribution, structure and production

    OpenAIRE

    Gutiérrez Merino, Emilia; Vallejo, V. Ramón; Romanyà i Socoró, Joan; Fons, J

    1991-01-01

    Evergreen Nothofagus betuloides and decidoues N. pumilo form the main forest types in Tierra del Fuego. These forest were sampled along two altitudinal gradients to study their structure and dynamics and assess the causes of their distribution.

  3. Tierra y familia en la España meridional, siglos XIII-XIX.

    Directory of Open Access Journals (Sweden)

    Igor Goicovic Donoso

    2011-10-01

    Full Text Available Las siete contribuciones recopiladas por Francisco García Gon-zález en el texto Tierra y familia en la España meridional, siglos XIII-XIX, nos sitúan frente a la historia social a partir de dos inflexiones epistemológicas íntimamente relacionadas en la historia: tierra y familia. Efectivamente, la diada tierra-familia, durante el Antiguo Régimen europeo, se convirtió en un factor explicativo de buena parte de los procesos de articulación de la sociedad. Así, la relación de los sujetos con la propiedad y usufructo de la tierra, y las formas de articulación familiar desplegadas por los mismos, tienden a imbricarse recurrentemente en complejos procesos de reproducción social.

  4. Taenia saginata Goeze, 1872 (Platyhelminthes: Cestoda: Taeniidae from an indigenous native from Tierra del Fuego, Chile

    Directory of Open Access Journals (Sweden)

    Eduardo I. Faúndez

    2015-06-01

    Full Text Available First record of Taenia saginata from an indigenous from Tierra del Fuego (Chilean Patagonia is reported, from museum material of the year 1902. The importance of the record is discussed. Illustrations of the specimen are given.

  5. El Canal del Atazar I

    Directory of Open Access Journals (Sweden)

    López de Berges y de los Santos, Emilio

    1967-03-01

    Full Text Available The Atazar Canal helps to supply Madrid with water, from the rivers Lozoya, Jarama and Sorbe. The section which operates at present starts at the Torrelaguna dam and finishes at the El Goloso reservoir. Later a further section will be added, from the Atazar dam, on the Lozoya river, to link up with the control dam at Torrelaguna. The canal capacity is 16 m3/sec, and it is 43.47 km long. It has a slope of 4/10.000. The cross section is similar to that of the Jarama canal, already built. There are interconnections between this canal and the Canal Alto, which previously supplied the high and medium part of Madrid. To overcome the ground unevenness 5 syphons have been built, the most important of which is the Colmenar Goloso syphon, which is 10.88 km in length. Construction commenced on December 10, 1962, and water reached Madrid on June 15th, 1966. The initial budget for this project was 1,500 million pesetas.El canal del Atazar refuerza considerablemente el abastecimiento de aguas a Madrid, procedentes de los ríos Lozoya, Jarama y, en un próximo futuro, del Sorbe. El tramo, actualmente en funcionamiento, empieza en el salto de Torrelaguna y finaliza en los depósitos de El Goloso. Más adelante se completará su trazado mediante un nuevo tramo que partirá del embalse de Atazar, en el Lozoya, para unirse al actual en el depósito regulador de Torrelaguna. Su capacidad es de 16 m3/s; su longitud, 43,471 km, y su pendiente, 4 diezmilésimas. La sección tipo es análoga a la del canal del Jarama, de construcción anterior. Mediante la oportuna obra de transvase se realizan intercambios entre este Canal y el Canal Alto que abastecía anteriormente la parte media y alta de la capital. Para salvar los desniveles del terreno se han construido 5 sifones, siendo el más importante el de Colmenar-Goloso, con una longitud de 10,8S4 km. El comienzo de las obras tuvo lugar el 10 de diciembre de 1962, y el agua llegó a Madrid el 15 de junio de 1966. Su

  6. Efecto de la impermeabilidad del Mucílago de Nopal en bloques de tierra comprimidos

    OpenAIRE

    Yolanda Guadalupe Aranda Jiménez; Edgardo Jonathan Suárez Domínguez

    2013-01-01

    La arquitectura de tierra1 es conocida desde hace siglos, sin embargo, actualmente es poco utilizada comparado con los sistemas constructivos comunes. Los bloques de tierra comprimido (BTC) son elementos constructivos con un potencial elevado para ser utilizado en las construcciones de vivienda en México, principalmente por su similitud con los bloques tradicionales, siendo conveniente mejorar sus características a partir de un estabilizante. Se realizó el estudio de BTC estabilizados con cem...

  7. Los sismos y la restauración del patrimonio en tierra en Perú

    OpenAIRE

    Hurtado Valdez, Pedro

    2010-01-01

    El uso de la tierra para construir ha sido una realidad permanente en toda la historia de Perú. Desde épocas prehispánica, pasando por la etapa del Virreinato y luego en la República, junto a los diversos sistemas de construcción con tierra se sucedieron muchas técnicas de restauración, desde las llamadas tradicionales hasta nuevas experimentales.

  8. Cultural tourism in fragile institutional contexts: project for cultural routes in Tierra del Fuego

    OpenAIRE

    Garcés Feliu, Eugenio

    2012-01-01

    The following paper presents a project of Cultural Routes designed for the Chilean Tierra del Fuego, linked to promoting tourism and boosting the economy, through the development of a specific high standard tourism offer, linked to its natural and cultural heritage, with the purpose of capturing the potential income generation for Chile. The project had as main goal to enhance the competitiveness of the tourism sector of special interests in Tierra del Fuego, a key sector of South...

  9. Retention of Root Canal Posts

    DEFF Research Database (Denmark)

    Sahafi, A; Benetti, Ana Raquel; Flury, S;

    2015-01-01

    The aim of this study was to investigate the effect of the cement film thickness of a zinc phosphate or a resin cement on retention of untreated and pretreated root canal posts. Prefabricated zirconia posts (CosmoPost: 1.4 mm) and two types of luting cements (a zinc phosphate cement [DeTrey Zinc......] and a self-etch adhesive resin cement [Panavia F2.0]) were used. After removal of the crowns of 360 extracted premolars, canines, or incisors, the root canals were prepared with a parallel-sided drill system to three different final diameters. Half the posts did not receive any pretreatment. The other...... half received tribochemical silicate coating according to the manufacturer's instructions. Posts were then luted in the prepared root canals (n=30 per group). Following water storage at 37°C for seven days, retention of the posts was determined by the pull-out method. Irrespective of the luting cement...

  10. Dose-effect studies with inhaled plutonium oxide in beagles

    International Nuclear Information System (INIS)

    Beagle dogs given a single exposure to 239PuO2 and 238PuO2 aerosols are being observed for life-span dose-effect relationships. The 239Pu body burden of the nine dogs that died of pulmonary fibrosis-induced respiratory insufficiency during the first 3 yr after exposure was 1 to 12 μCi. One of these dogs had a pulmonary tumor; nine additional dogs with body burdens of 0.6 to 1.8 μCi died due to pulmonary neoplasia 3 to 6 yr after exposure. Two of the dogs exposed to 238Pu have died during the first 4 yr postexposure, due to bone and lung tumors, with body burdens at death of 10 μCi. Lymphocytopenia was the earliest observed effect after inhalation of 239PuO2 or 238PuO2, occurring 0.5 to 2 yr after deposition of equal to or greater than 80 nCi plutonium in the lungs

  11. Dose-effect studies with inhaled plutonium oxide in beagles

    International Nuclear Information System (INIS)

    Beagle dogs given a single exposure to 239PuO2 and 238PuO2 aerosols are being observed for life-span dose-effect relationships. The 239Pu body burden of the nine dogs that dies of pulmonary fibrosis-induced respiratory insufficiency during the first 3 yr after exposure was 1 to 12 μCi; one of these dogs had a pulmonary tumor. Eleven additional dogs with body burdens of 0.6 to 1.8 μCi died due to pulmonary neoplasia 3 to 7 yr after exposure. Four of the dogs exposed to 238Pu have died during the first 4 1/2 yr postexposure due to bone and/or lung tumors; the body burden at death ranged from 6 to 10 μCi. Lymphopenia was the earliest observed effect after inhalation of 239PuO2 or 238PuO2, occurring 0.5 to 2 yr after deposition of greater than or equal to 80 nCi plutonium in the lungs

  12. Toxicity of inhaled 91YCl3 in Beagle dogs. XVIII

    International Nuclear Information System (INIS)

    The metabolism, dosimetry, and biological effects of inhaled 91YCl3 were studied in Beagle dogs. Forty-two dogs with initial 91Y body burdens from 14 to 1300 μCi/kg (0.52-48 MBq/kg) body weight and 12 control dogs were observed during their life spans. Four additional dogs with a mean initial body burden of 180 μCi 91Y/kg (6.7 MBq/kg) body weight were placed in a sacrifice study. All 46 of the exposed dogs and all 12 of the control dogs have died. Dogs with the highest initial body burdens died with bone marrow damage and pancytopenia. Of the dogs dying of late-occurring effects, three died with nasal cavity carcinomas, three died with pulmonary carcinomas, and one died with hepatic hemangiosarcoma. These cancers all appeared to be related to radiation injury. Control dogs died of miscellaneous neoplastic and chronic diseases. 1 reference, 1 figure, 3 tables

  13. Retention of plutonium in the beagle after gastrointestinal absorption

    International Nuclear Information System (INIS)

    A 0.01 M bicarbonate solution containing 130 nCi (approx. 5 kBq) of 237Pu (90% hexavalent, 93% ultrafilterable) was administered via gelatin capsule to six adult male beagles following a 21-hr fast. The dogs were sacrificed after 5-6 weeks and the percentage of the administered plutonium retained in the liver plus skeleton and its distribution within the skeleton were determined. The mean amount retained in these tissues was (0.063 +- 0.006)% of the administered dose. The mean amounts of plutonium in the liver and the skeleton were approximately equal, and the distribution within the skeleton was similar to that observed by other workers following either intravenous injection or inhalation. The value for plutonium retention by the dog is about a factor of three less than the values the authors have reported for rodents. It is a factor of 7 greater than the product of the values for gastrointestinal absorption (f1) and fractional retention (f2) recommended by the ICRP for man

  14. Development of the canine tooth in the beagle

    International Nuclear Information System (INIS)

    The growth of the crown and root in the canine tooth of beagle dogs were observed macroscopically and radiographically, and changes of occlusion with age were investigated. Completion of growth in the crown of the canine tooth was observed in both mandible and maxilla, and its eruption was accompanied by development of the dental root. The permanent canine erupted on the lingual side of deciduous canine in the mandible, and on the mesial side of the deciduous canine in the maxilla. Movement of the permanent canine to normal occlusal position(buccal direction in mandibular canine, and distal direction in maxillary canine)was followed by the loss of the deciduous canine. Coexistence of the permanent and deciduous canines occurred for about 2.4 weeks in the maxilla and about 1.4 weeks in the mandible, on average. Macroscopically, the growth of the permanent canine was completed by 33 weeks of age in the mandible and about 34 weeks of age in the maxilla. The mature root of the permanent canine was recognized radiographically at about 43 weeks of age in the mandible and 47 weeks of age in the maxilla

  15. Dose-effect studies with inhaled plutonium oxide in beagles

    International Nuclear Information System (INIS)

    Beagle dogs given a single exposure to 239PuO2 and 238PuO2 aerosols are being observed for life-span dose-effect relationships. The 239Pu body burden of the nine dogs that died of pulmonary-fibrosis-induced respiratory insufficiency during the first 3 yr after exposure was 1 to 12 μCi; one of these dogs had a pulmonary tumor. Seventeen additional dogs, with body burdens of 0.2 to 1.8 μCi, died due to pulmonary neoplasia 3 to 8 yr after exposure. Ten of the dogs exposed to 238Pu have died during the first 5 1/2 yr postexposure due to bone and/or lung tumors; the body burden at death ranged from 1.5 to 10 μCi. Lymphopenia was the earliest observed effect after inhalation of 239PuO2 or 238PuO2, occurring 0.5 to 2 yr after deposition of >80 nCi plutonium in the lungs

  16. Beagle 2 and NASA's Mars 2003 Orbiter: A Unique Exobiology Opportunity with an Orbiter

    Science.gov (United States)

    Gibson, Everett K., Jr.; Pillinger, Colin T.; Thatcher, John; Westall, Frances

    2000-01-01

    With the exploration strategy for Mars undergoing reexamination, the opportunity exists for the incorporation of the 60 kg Beagle 2 lander, developed in the United Kingdom for inclusion on ESA's 2003 Mars Express mission, with NASA's Mars 2003 orbiter derived from the Mars Global Orbiter. The combination of Beagle 2 with a Mars orbiter would result in a unique mission which could obtain information on Mars' life, climate and resources both from orbit as well as on the surface of the planet. Beagle 2 has been developed in the LJK for ESA as a low-cost opportunity to study the exobiology of Mars and the spacecraft is in its final stages of manufacture. Only limited modifications to the Beagle 2 package would be required for inclusion on NASA's Mars 2003 orbiter. With the ESA Mars Express mission launch in 2003 and a potential NASA Mars orbiter in 2003, both Beagle 2 landers on Mars would offer a low-cost, decreased risk and increased science return opportunity for the exploration of Mars at two distinct geologically interesting sites.

  17. Recent Deglaciation of Darwin Mountains (Tierra de Fuego) after Little Ice Age: monitoring by photogrammetry, lichenometry, dendrochronology and field studies.

    Science.gov (United States)

    García-Sancho, L.; Palacios, D.; Zamorano, J. J.; Green, A.; Vivas, M.; Pintado, A.

    2012-04-01

    Glaciers from the Darwin mountain range have been retreating since the Little Ice Age (LIA). However, the amount of retreat varies and is minimal for some glacial snouts and substantial for others. Possible explanations for this different behaviour include climatic and glacial dynamic causes. The aim of this work was to analyse the impact of climate change on these glaciers. The research site was the terminus of glacier Pia, which descends to the south of Mount Darwin (2488 m asl, 54°45'S, 69°29'W) and reaches the coastline at the Beagle Channel. The terminus is situated some hundreds of meters above the LIA moraine but, whereas one sector retreated rapidly and then stabilized, another sector has had several advances and retreats leaving a number of moraine arches. To better understand the origin of this dynamic behaviour, we undertook a study of the evolution of the terminus of glacier Pia over the last 60 years. We used aerial photographs and satellite images to determine the exact location of the glacial terminus in certain years (1943, 1963, 1987, 1990, 2001 and 2006). These results were completed in 2008 and 2009 through field work. We also carried out lichenometric studies of the two most abundant lichen species that rapidly colonize the moraine boulders abandoned by the glacier: Placopsis perrugosa and Rhizocarpon geographicum. By comparing results from field work carried out in 2008 and 2009, we were able to determine the growth rate of these two species (García-Sancho et al. 2011). In addition, we also carried out a dendrochronological study of Nothofagus antarctica and N. betuloides. The use of the four techniques involved in this study (photogrammetry, lichenometry, dendrochronology and multiyear field work) allowed us to establish the ecesis period of each species as well as their growth curves, from which we can deduce the movements of the glacial terminus from the end of the LIA to the present. From this study we can infer that the different

  18. INSTRUMENTATION OF CURVED CANALS: A REVIEW

    Directory of Open Access Journals (Sweden)

    Senthil Kumar

    2013-02-01

    Full Text Available INTRODUCTION: Nature seldom draws a straight line. Nowhere is thi s more apparent than in the anatomy of teeth roots and root canal systems o f human teeth. Even teeth with straight roots can harbor severely curved canals. Canal shapi ng is a critical aspect of endodontic treatment because it influences the outcome of the subsequent phases of canal irrigation and filling and the success of the treatment itself. In fact, curved canals are the most common endodontic complexity 1 . The need for some manner of root canal preparation pri or to root canal filling has long been recognized as an essential step in endodontic t reatment. Concepts concerning the role and purpose of this canal preparation, however, have differ ed remarkably at different times in the development of endodontics and in the hands of diffe rent practitioners 2

  19. Quantification of brown dog tick repellents, 2-hexanone and benzaldehyde, and release from tick-resistant beagles, Canis lupus familiaris

    Science.gov (United States)

    We have recently shown that repellency of the tick Rhipicephalus sanguineus sensu lato by the tick resistant dog breed Beagle is mediated by volatile organic compounds 2-hexanone and benzaldehyde present in Beagle dog odour. Ectoparasite location on animal hosts is affected by variation in odour com...

  20. Quantification of brown dog tick repellent, 2-hexanone and benzaldehyde, release from tick-resistant Beagle dogs, Canis lupus familiaris

    Science.gov (United States)

    We have recently shown that repellency of the tick Rhipicephalus sanguineus sensu lato by the tick resistant dog breed Beagle is mediated by volatile organic compounds 2-hexanone and benzaldehyde present in Beagle dog odour. Ectoparasite location on animal hosts is affected by variation in odour com...

  1. Computed tomography of the thoracic canal

    International Nuclear Information System (INIS)

    Under the adequate CT condition, thoracic canal was studied in twelve normal cases, nine cases of cervical myelopathy with developmental cervical canal stenosis and four cases of thoracic myelopathy with ossification of thoracic yellow ligament. The results were as follows. 1) The adequate condition for delineation of thoracic canal seemed to be nearly 400 EMI units in window width and 150 in level. Scanning angle was permitted within about 100. Bony thoracic canal was well scanned at the center of vertebral body. 2) The configulation of the normal thoracic canal was oval at Th1, Th2 levels and round at Th3-Th10 and large oval at Th11, Th12. The sagittal diameter was almost fixed at each level and the transverse diameter was large at upper and lower levels and small at middle levels. 3) Thoracic canal was narrowed in the cases of cervical myelopathy with developmental cervical canal stenosis especially in sagittal diameter, but not narrowed in transverse diameter. Three of four cases who had myelopathy with ossification of thoracic yellow ligament had narrow canals. 4) There was a good relation between sagittal diameter of cervical canal and thoracic canal. 5) There was a good relation between sagittal diameter of thoracic canal measured by conventional radiographs (Hattori's method) and CT scans. The author thinks that Hattori's method is useful to diagnose the thoracic canal stenosis. (author)

  2. The early pathology and image study of percutaneous laser disc decompression in beagles

    International Nuclear Information System (INIS)

    Objective: To explore the cause, influencing factor and possible solving method of transient adverse reactions during the operation. Methods: Sixteen healthy beagles were undergone virtual PLDD. The changes of vertebral discs and the surrounding tissues were observed by high resolution CT and MRI at different periods after the operation, and the same investigation procedure was carried out after the sacrifice of beagles. Results: The beagles of the conventional vaporization group occasionally had limb tic and whining in the operations. Pieces of necrosis and edema could be found in the tissues of intervertebral foramen at the paracentetic side. The histological changes in the negative pressure suction group were less than those in the conventional group. Conclusion: The reversible damages of the surrounding tissuses were observed in the conventional group and continuing negative pressure suction during the operations can prevent the damages to the surrounding tissues, all of the changes could be clearly displayed by CT and MRI scan. (authors)

  3. Contemporary root canal filling strategies

    NARCIS (Netherlands)

    A.T. Moinzadeh

    2016-01-01

    Currently, clinicians can choose from a wide range of root canal filling materials and techniques, some of which have been evaluated in this thesis. Methacrylate resin-based sealers suffer from polymerization shrinkage stresses. This limitation may partly be overcome by a two-step cementation proced

  4. Canal Water Scarcity Hits Farmers

    Institute of Scientific and Technical Information of China (English)

    张忠潮

    2007-01-01

    Acute shortage of canal water for irrigation in this district has caused resentment among the farmers.The water is being released in the various channels for just one week in a month,which is not enough to meet the irrigation needs of the farmers who are preparing their fields for paddy

  5. The Dehiscent Facial Nerve Canal

    Directory of Open Access Journals (Sweden)

    Sertac Yetiser

    2012-01-01

    Full Text Available Accidental injury to the facial nerve where the bony canal defects are present may result with facial nerve dysfunction during otological surgery. Therefore, it is critical to know the incidence and the type of facial nerve dehiscences in the presence of normal development of the facial canal. The aim of this study is to review the site and the type of such bony defects in 144 patients operated for facial paralysis, myringoplasty, stapedotomy, middle ear exploration for sudden hearing loss, and so forth, other than chronic suppurative otitis media with or without cholesteatoma, middle ear tumors, and anomaly. Correlation of intraoperative findings with preoperative computerized tomography was also analyzed in 35 patients. Conclusively, one out of every 10 surgical cases may have dehiscence of the facial canal which has to be always borne in mind during surgical manipulation of the middle ear. Computerized tomography has some limitations to evaluate the dehiscent facial canal due to high false negative and positive rates.

  6. Real-time implementation of logo detection on open source BeagleBoard

    Science.gov (United States)

    George, M.; Kehtarnavaz, N.; Estevez, L.

    2011-03-01

    This paper presents the real-time implementation of our previously developed logo detection and tracking algorithm on the open source BeagleBoard mobile platform. This platform has an OMAP processor that incorporates an ARM Cortex processor. The algorithm combines Scale Invariant Feature Transform (SIFT) with k-means clustering, online color calibration and moment invariants to robustly detect and track logos in video. Various optimization steps that are carried out to allow the real-time execution of the algorithm on BeagleBoard are discussed. The results obtained are compared to the PC real-time implementation results.

  7. Transsphenoidal hypophysectomy in beagle dogs: evaluation of a microsurgical technique

    International Nuclear Information System (INIS)

    Objective-Assessment of a microsurgical technique for transsphenoidalhypophysectomy in dogs. Study Design-Prospective study using physicalexamination, pituitary function testing, computed tomography (CT), and histological examination at autopsy. Animals or Sample Population-Eight laboratory beagle dogs. Methods-Pituitary function was assessed before and at 10 weeks after hypophysectomy by combined administration of four releasing hormones (anterior pituitary), administration of haloperidol (pars intermedia), and infusion of hypertonic saline (posterior pituitary). Results-CT imaging enabled accurate preoperative localization of the pituitary. Appropriate positioning and surgical technique facilitated exposure of the pituitary and its extraction without hemorrhage. Postoperative recovery was generally uncomplicated. None of the eight dogs had somatotropic. gonadotropic, lactotropic, melanotropic, or posterior pituitary responses to stimulation at 10 weeks after hypophysectomy. Four dogs (ACTH nonresponders) also had no corticotropicresponse and four (ACTH responders) bad small but significant responses in the combined anterior pituitary function test. Adrenocortical atrophy was more pronounced in the ACTH nonresponders than in the responders. No residual pituitary tissue was found along the ventral hypothalamic diencephalon but nests of pituitary cells were found embedded infibrous tissue in the sella turcica. Conclusions-The surgical technique proved to be safe and effective. Microscopic nests of pituitary cells in the sella turcica may be responsible for residual corticotropic response to hypophysiotropic stimulation after hypophysectomy. Clinical Relevance-The surgical technique may be used in the treatment of dogs with pituitary-dependent hyperadrenocorticism. The corticotropic response is the most sensitive criterion in assessing completeness of hypophysectomy in dogs. (C) Copyright 1997 by The American College of Veterinary Surgeons

  8. Complement activation associated with polysorbate 80 in beagle dogs.

    Science.gov (United States)

    Qiu, Shidong; Liu, Zhaohua; Hou, Li; Li, Yuanyuan; Wang, Jiao; Wang, Hong; Du, Wu; Wang, Wenfang; Qin, Yizhuo; Liu, Zhaoping

    2013-01-01

    Polysorbate 80 (Tween® 80) is the most extensively used surfactant in parenteral drug formulation. Its application as an adjunct for intravenous drug administration is approved by the Food and Drug Administration. However, severe hypersensitive reactions, which are typical non-immune anaphylactic reactions (pseudoallergy) characterized by the release of histamine and unvaried IgE antibodies, have been associated with Tween® 80. In order to explore the non-immune anaphylactic mechanisms of Tween® 80, we performed in vivo experiments to assess the changes in physiological and hematologic indicators after intravenous injection of Tween® 80 into dogs. Tween® 80 induced the release of histamine, and a 2-fold increase in SC5b-9, 2.5-fold increase in C4d, 1.3-fold increase in Bb, while IgE remained unchanged. It also produced changes in pulmonary pressure, systemic pressure and ECG. In in vitro experiments, Tween® 80 was incubated with dog serum in the presence of an inhibitor of complement activation (EGTA/Mg(2+)). Under these conditions, Tween® 80 increased the contents of C4d and Bb. The results of this study reveal that Tween® 80 can cause cardiopulmonary distress in dogs and activate the complement system through classical and alternative pathways as indicated in both in vivo and in vitro preparations. Moreover, they demonstrate the utility of the beagle dog as an animal model for the study of complement activation-related pseudoallergy. These findings raise concerns with regard to the indiscriminate use of Tween® 80 in clinical applications. PMID:23159336

  9. Toxicity of inhaled 91YCl3 in Beagle dogs. XII

    International Nuclear Information System (INIS)

    Studies on the metabolism, dosimetry and effects of inhaled 91YCl3 in Beagle dogs are being continued to provide information that will aid in assessing the biological consequences of nuclear accidents in which 91Y or other radionuclides that produce a similar radiation dose pattern may be released. Forty-two dogs with 91Y initial body burdens from 64 to 1300 μCi/kg body weight was placed in four groups with mean lung burdens of 310, 180, 75 and 40 μCi/kg body weight. These dogs and 12 control dogs are being maintained for lifetime observation. An additional group of four dogs with a mean initial 91Y body burden of 180 μCi/kg body weight was placed in a sacrifice study. Twenty-six of the exposed dogs and four of the control dogs have died. Eleven dogs within the highest activity level groups died or were euthanized at 12 to 33 days after inhalation of 91Y with changes related to severe bone marrow damage and associated pancytopenia. Two dogs died approximately one year after 91Y inhalation with convulsive seizures that were presumed to be unrelated to the 91Y exposure. Nine 91Y-exposed dogs died or were euthanized due to neoplasms 2012 to 4115 days after exposure. Three dogs had nasal squamous cell carcinomas, one had a bronchioloalveolar carcinoma, one a mast cell sarcoma, one a mammary adenocarcinoma, one a malignant lymphoma, one a melanosarcoma in the mouth and one heart base tumor. Two dogs died of renal failure 2663 and 4086 days after exposure. One dog died with autoimmune hemolytic anemia 3888 days after exposure and one died with congestive heart failure 4042 days after inhalation exposure. One control dog died of empyema, another control dog died with a mammary adenocarcinoma, one died with congestive heart failure and one with malabsorption syndrome. Serial observations are continuing on all surviving dogs

  10. Mandibular Second Premolar with Four Canals

    Directory of Open Access Journals (Sweden)

    Javad Ghiasi

    2015-09-01

    Full Text Available A mandibular second premolar with four canals is an interesting example of anatomic variations. This report describes a case of a mandibular second premolar with three roots and four canals (one mesiobuccal, two distobuccal and one lingual. The canals were prepared using K-files and irrigated with NaOCl (5.25% and normal saline as the final irrigant. The canals were filled laterally with gutta percha and AH26 sealer (De Trey, Dentsply, Switzerland. This case shows a rare anatomic configuration and points out the importance of looking for additional canals.

  11. Scalloping at the lumbosacral canal

    Energy Technology Data Exchange (ETDEWEB)

    Reinhardt, R.

    1987-07-01

    Scalloping is an indentation of the dorsal side of the vertebral body (anterior wall of the lumbosacral or sacral canal) which typically involves several adjacent lumbal vertebral body segments and the anterior wall of the canalis sacralis. Occurrence without underlying disease is rare; it occurs most frequently with chondrodystrophy, neurofibromatosis, Morquio's syndrome, Hurler's syndrome, acromegaly, Ehlers-Danlos syndrome, Marfan's syndrome, cysts, tumors and in peridural lipomas.

  12. Scalloping at the lumbosacral canal

    International Nuclear Information System (INIS)

    Scalloping is an indentation of the dorsal side of the vertebral body (anterior wall of the lumbosacral or sacral canal) which typically involves several adjacent lumbal vertebral body segments and the anterior wall of the canalis sacralis. Occurrence without underlying disease is rare; it occurs most frequently with chondrodystrophy, neurofibromatosis, Morquio's syndrome, Hurler's syndrome, acromegaly, Ehlers-Danlos syndrome, Marfan's syndrome, cysts, tumors and in peridural lipomas. (orig.)

  13. Contemporary root canal filling strategies

    OpenAIRE

    Moinzadeh, A.T.

    2016-01-01

    Currently, clinicians can choose from a wide range of root canal filling materials and techniques, some of which have been evaluated in this thesis. Methacrylate resin-based sealers suffer from polymerization shrinkage stresses. This limitation may partly be overcome by a two-step cementation procedure. This alternative placement technique results in an increase and homogenization of the adhesion of the material to intraradicular dentin. Subsequent research should aim at developing sealers wi...

  14. Preliminary considerations for an in-depth investigation of thyroid disease in the CRHL beagle colony

    International Nuclear Information System (INIS)

    This report describes preliminary results of evaluation of selected clinical laboratory data from hypothroid and euthyroid beagles as an initial step in an in-depth study of hypothyroidism in the CRHL colony. Both hyperchloesterolemia and a decreased hematocrit were present in dogs with clinically diagnosed or pathologically confirmed thyroid disease

  15. Late effects of inhaled 238PuO2 in beagles

    International Nuclear Information System (INIS)

    Osteosarcomas were the primary cause of death in beagle dogs 4 to 8 years after inhalation of 238PuO2. The plutonium body burden at death ranged from 0.4 to 2.6 μCi with 32 to 55 percent of the plutonium in the skeleton. Pulmonary neoplasia was observed in three of the bone-tumor-bearing dogs

  16. Effects of inhaled 239PuO2 on the primary immune response of beagle dogs

    International Nuclear Information System (INIS)

    Effects of inhaled 239PuO2 on the humoral component of the immune system were measured by intravenous immunizations of beagle dogs with keyhole limpet hemocyanin (KLH). With this T-cell-dependent antigen, a significant decrease in primary antibody response was observed in exposed versus unexposed dogs

  17. Clotting mechanism in beagles irradiated by 4.5 Gy γ-rays

    International Nuclear Information System (INIS)

    Objective: To explore the clotting mechanism in beagles irradiated by 4.5 Gy γ-rays after treatment with supportive care, or supportive care and combined cytokines. Methods: Sixteen beagles were divided into irradiation control group, Supportive care group and combined cytokines treatment group. Platelet aggregation test, thrombelastography (TEG) and the time measurement were analyzed in vitro. Results: In irradiation group and supportive care group, the platelet aggregation rates in beagles were decreased markedly and the k value of TEG was increased 7 d post-irradiation, while those indexes in combined cytokines treatment group changed little. At 14 d post-irradiation, each parameter of TEG in irradiated group changed obviously. The values of r, k, r + k and M were elevated significantly, clotting time and the maximum coagulation time of thrombus delayed, the Ma value was decreased markedly, and the maximum elasticity amplitude of thrombus was diminished. All parameters in combined cytokines treatment group were better than those in supportive care group. The thrombin time was prolonged obviously in irradiated group 14 d post-irradiation, while the thrombin time was the longest at 2-3 weeks post irradiation in supportive care group and combined cytokines treatment group (P>0.05). Conclusions: Cytokines could improve the platelet aggregation and the blood clotting functions of beagles suffering from acute radiation sickness. (authors)

  18. Reference Intervals, Intraindividual and Interindividual Variability, and Reference Change Values for Hematologic Variables in Laboratory Beagles

    OpenAIRE

    Bourgès-Abella, Nathalie H; Gury, Thierry D; Geffré, Anne; Concordet, Didier; Thibault-Duprey, Kevin C; Dauchy, Arnaud; Trumel, Catherine

    2015-01-01

    In research and development studies for human and veterinary medicine, relevant comparators for interpreting clinical pathology results are matched with concurrent control animals. However, reference intervals (RI) provide a comparator database and important aids for interpreting clinical pathology data, especially in laboratory beagle dogs. Furthermore, RI incorporate biologic variation, which includes analytical, intraindividual, and interindividual variation. No studies to date have establ...

  19. Disposition of 241AmO2 following inhalation by beagle dogs

    International Nuclear Information System (INIS)

    Translocation of 241Am from the lungs of beagles following inhalation of AmO2 was fairly rapid, roughly equal quantities being found in the liver and skeleton at all postexposure times to 810 days. Less than 16 percent of the initial body burden was excreted, more than two-thirds of this in the feces

  20. Clinical status and philosophy of clinical care of radionuclide-treated beagles

    International Nuclear Information System (INIS)

    A manual for therapy of beagles is reviewed. The following protocol is outlined and described: antibiotic therapy, chemotherapy for neoplasms, hormone therapy, nutritional therapy, radiation therapy, steroid therapy, and miscellaneous treatments. The manual also includes sections on diagnosis and discussions of individual cases. Tables summarizing clinical cases seen during 1974 are presented

  1. Geología y ciencias de la tierra: etimología y un poco de historia

    OpenAIRE

    Anguita, Francisco

    1996-01-01

    La Geología, o tratado de la Tierra, y las Ciencias de la Tierra, o conjunto de conocimientos sobre la Tierra, no constituyen campos de conocimiento coincidentes. Es evidente que la Geología es una Ciencia de la Tierra; pero el dato esencial es que la Geología clásica se construyó sobre una tradición geográfica, mientras que las Ciencias de la Tierra están basadas en una síntesis de la tradición naturalista con metodologías propias de las Ciencias Físicas, como la modelización y la cuantifica...

  2. Tierras, mujeres y niñez. Familia y conflicto armado

    OpenAIRE

    Sandra Zorio

    2015-01-01

    Este artículo pretende realizar un análisis socio-jurídico sobre la situación de las mujeres, los niños, niñas y adolescentes y su derecho a la tierra, específicamente, en la aplicación de la Ley de Víctimas y Restitución de Tierras. Se pretende demostrar que a pesar de existir un conjunto de normativas amplias y garantistas en favor de estas poblaciones, las instituciones del Estado encargadas de los temas de tierras no logran recoger en sus procedimientos de política pública la realidad soc...

  3. «Huarpes no tan huarpes» y «hombres modernos»: interpelaciones étnicas y disputas por las últimas tierras irrigadas en Mendoza (Argentina

    Directory of Open Access Journals (Sweden)

    Leticia Saldi

    2015-05-01

    Full Text Available A través de un estudio etnográfico en la periferia del oasis de riego más importante del centro-oeste argentino, se analiza la intervención de persistentes representaciones étnico-raciales y ambientales en la delimitación de áreas irrigadas y de grupos sociales que ostentan la tenencia del agua y la tierra. Los grupos situados a uno y otro lado de los últimos canales de riego son interpelados desde paradigmas modernistas que vinculan a la tenencia del agua, la propiedad privada y la producción vitivinícola con la herencia europea y la idea de progreso, mientras que lo no irrigado, la tenencia comunitaria de la tierra y el pastoreo trashumante se asocia a la descendencia indígena huarpe y a la idea de atraso o involución. Debido a la presencia de dos espacios y grupos socio-culturales supuestamente autónomos, opuestos y separados por los últimos canales de riego es que se los conceptualiza como frontera hídrica. Esta, a pesar de ser considerada como natural y fija, es por el contrario artificial y dinámica, producto de luchas sociales y simbólicas por el agua y por la obtención de legitimidad como grupo socio-cultural capaz de obtenerla y controlarla. Asimismo se resaltan la presencia no solo de actores liminales, ni huarpes ni de origen europeo, sino también de alianzas que pueden llevar a la reconfiguración de espacios irrigados y de grupos socioculturales capaces de dar batalla en las disputas por los recursos naturales.

  4. Instrumentos para el desarrollo de dueños de pequeñas tierras forestales

    OpenAIRE

    José Rente Nascimento; José Luis B. Mota Villanueva

    2004-01-01

    Una de las formas de enfrentar los problemas derivados de la fragmentación de las tierras de vocación forestal (TVF) es la adopción de estrategias de intervención que lleven a la integración de las pequeñas propiedades en unidades productivas mayores o que permitan la utilización de tecnologías propias para propiedades mayores. Este es uno de los resultados del estudio "Instrumentos para el desarrollo de pequeñas tierras de vocación forestal". Dicha investigación utilizó una metodología de re...

  5. Análisis de las construcciones en tierra cruda en el Algarve

    OpenAIRE

    Braga, Alfredo Manuel Gonçalves Silva; Graça, Ana Teresa

    2012-01-01

    La tierra cruda, como material de construcción, es utilizada por el hombre desde hace miles de años y continúa siendo en la actualidad una de las formas más generalizadas de edificar a nivel mundial. El estudio de la construcción de tierra se justifica por diversas razones. En primer lugar, por la necesidad de preservar un patrimonio cultural y arquitectónico insustituible. En segundo lugar, por constituir el único recurso disponible en los países llamados "subdesarrollados" y por último,...

  6. Do crustal deformations observed by GPS in Tierra del Fuego (Argentina) reflect glacial-isostatic adjustment?

    Science.gov (United States)

    Mendoza, L.; Richter, A.; Hormaechea, J. L.; Perdomo, R.; Del Cogliano, D.; Dietrich, R.; Fritsche, M.

    2010-09-01

    Vertical site velocities determined by geodetic GPS observations in the Lago Fagnano area, Tierra del Fuego main island, are interpreted with respect to their potential relation with the glacial-isostatic crustal response to ice mass changes. The spatial pattern of the uplift rates, in combination with the horizontal crustal deformation pattern, point towards a fault-tectonic rather than glacial-isostatic origin of the determined vertical crustal deformations. This implies rather small GIA effects pointing towards relatively small Holocene ice-mass changes in Tierra del Fuego. However, these findings are considered to be preliminary. They should be confirmed by additional observations covering an extended area with GPS sites.

  7. La Tierra de Madrid en la época del Fuero (siglos XII-XIII)

    OpenAIRE

    Fernández Montes, Matilde

    2004-01-01

    Se estudian los límites de la Comunidad de Villa y Tierra de Madrid, fijados y consolidados durante los siglos XII y XIII, estudiándose los usos permitidos y delictivos que se dan a la tierra y los factores que intervienen el resultado final: antigua extensión en época islámica, presiones y conflictos con comunidades limítrofes, concesiones reales al concejo, nobleza e iglesia y por último la práctica de la presura.

  8. Stability of guest molecules in urea canal complexes by canal polymerization

    International Nuclear Information System (INIS)

    It was found that various organic materials are attracted into urea canal by hexanediol diacrylate (HDDA) and long chain compounds. This means that materials which does not form complex by itself are induced in canal by HDDA and long chain compounds. To include with stability perfumes, insecticides, attractants and repellents in urea canal, leaf alcohol was used as a model compound for guest molecules in the canal. The leaf alcohol from the canal released gradually over many days and the release was inhibited for 15 days by long chain compounds and for 30 days by polymerized HDDA after irradiation. After releasing, the leaf alcohol in the canal remained 25 % stable for long chain compounds and 40 % for polymerized HDDA. The dose required for stabilization of leaf alcohol in the urea canal by canal polymerization of HDDA was 30 kGy. (author)

  9. Endoscopic posterior decompression of lumbar canal stenosis

    OpenAIRE

    Yad Ram Yadav; Nishtha Yadav; Vijay Parihar; Yatin Kher; Shailendra Ratre

    2013-01-01

    Lumbar canal stenosis (LCS) is quite common. Surgery is indicated when patient fails to improve after conservative treatment. Endoscopic technique can be used in LCS and lateral recess stenosis. It can be performed in degenerative canal stenosis or with disc bulges. Bilateral severe bony canal stenosis and unstable spine are the contraindications. This procedure should be avoided in patients with a history of trauma. Detailed history and thorough physical examination should be performed to fi...

  10. Maxillary First Molar with Two Root Canals

    OpenAIRE

    2013-01-01

    Knowledge regarding the anatomic morphology of maxillary molars is absolutely essential for the success of endodontic treatment. The morphology of the permanent maxillary first molar has been reviewed extensively; however, the presence of two canals in a two-rooted maxillary first molar has rarely been reported in studies describing tooth and root canal anatomies. This case report presents a patient with a maxillary first molar with two roots and two root canals, who was referred to the Depar...

  11. Maxillary canine with two root canals

    OpenAIRE

    Nagesh Bolla; Sarath Raj Kavuri

    2011-01-01

    To report a rare case of maxillary canine with two root canals. The case describes the treatment of a maxillary canine with two root canals which was referred from department of prosthodontia for intentional root canal treatment for prosthetic rehabilitation. Clinical examination revealed a maxillary canine with carious lesion and responded within normal limits to electric pulp test. Radiographic examination revealed a distal carious lesion (close proximity to pulp) and also appeared to be an...

  12. The number and probability of canalizing functions

    OpenAIRE

    Just, Winfried; Shmulevich, Ilya; Konvalina, John

    2003-01-01

    Canalizing functions have important applications in physics and biology. For example, they represent a mechanism capable of stabilizing chaotic behavior in Boolean network models of discrete dynamical systems. When comparing the class of canalizing functions to other classes of functions with respect to their evolutionary plausibility as emergent control rules in genetic regulatory systems, it is informative to know the number of canalizing functions with a given number of input variables. Th...

  13. The petromastoid canal on computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Krombach, G.A.; Schmitz-Rode, T.; Weidner, J.; Guenther, R.W. [Department of Diagnostic Radiology, University of Technology, Pauwelstrasse 30, 52057 Aachen (Germany); Prescher, A. [Department of Anatomy, University of Technology, Pauwelstrasse 30, 52057 Aachen (Germany); DiMartino, E. [Department of Otorhinolaryngology, University of Technology, Pauwelstrasse 30, 52057 Aachen (Germany)

    2002-11-01

    The objective was to assess visibility and anatomy of the petromastoid canal in high-resolution CT. Computed tomography images of 188 patients were reviewed for delineation of the petromastoid canal. This bony canal connects the mastoid antrum with the cranial cavity and houses the subarcuate artery and vein. The diameter, obtained in the middle portion of the canal, was compared with the diameter of the vestibular and cochlear aqueduct in all patients, and absolute values measured in 20 cases. Collimation was 1 mm in 164 and 2 mm in 24 examinations. Additionally, temporal bone of a cadaver was imaged and microdissected. The petromastoid canal was identified bilaterally in all 164 scans that were obtained with a slice thickness of 1 mm. In 5 of the 24 patients imaged with a collimation of 2 mm, the canal was not visible, most probably due to partial-volume effects. The petromastoid canal had the same diameter as the cochlear aqueduct in 42/44 (right/left), exceeded it in 66/61 and was smaller in 75/78 cases. In comparison to the vestibular aqueduct it had an equal diameter in 38/41 (right/left), exceeded it in 63/61, and was rated as smaller in 82/81 temporal bones. Diameters for the canals were: petromastoid canal 0.51{+-}0.04 mm; cochlear aqueduct 0.57{+-}0.03; and vestibular aqueduct 0.63{+-}0.06 mm. Microdissection of the specimen revealed the entire course of the canal and demonstrated a similar appearance of the structure as in the images. The petromastoid canal can easily be identified on high-resolution, thin-slice CT images. Knowledge of the anatomy of this bony canal prevents misinterpretation as pathological structure, such as fracture line, which might occur if this structure is not known. (orig.)

  14. The cerebrovascular structure and brain tissue volume: a comparative study between beagle dogs and mongrel dogs

    International Nuclear Information System (INIS)

    Objective: To compare the differences of cerebrovascular structure and brain tissue volume between beagle and mongrel dogs by using angiography and MR scanning. Methods: A total of 40 dogs, including 20 beagle dogs (beagle group) and 20 mongrel dogs (mongrel group), were enrolled in this study. Under general anesthesia, all dogs were examined with cerebral angiography and MR scanning. The cerebrovascular structure was evaluated with angiography via selective catheterization of aortic arch, bilateral external cerebral arteries (ECA), maxillary arteries, internal cerebral arteries (ICA) and vertebral arteries separately. The diameters of the ICA, middle cerebral artery (MCA), rostral cerebral artery (RCA), the anastomosis channel ICA and ECA, and basilar artery (BA) were measured at the similar point of each dog. Meanwhile the volumes of the brain tissue were calculated in coronal T2 view of MR scanning. The statistical analysis was performed among the weight of dogs, the diameter of arteries and the volume of brain tissue. The differences in the diameters and brain tissue volume were compared between the two groups. Results: No obvious variations in the cerebrovascular structure and brain tissue volume were found in these dogs. One mongrel dog was excluded from this study because of the severe stenosis of ICA. The mean weight of 20 beagle dogs and 19 mongrel dogs was (12.81±1.29) kg and (12.85±1.12) kg, respectively. The diameters of the ICA, MCA, RCA, the anastomosis channel between ICA and ECA and BA in beagle group were (1.26±0.07) mm, (0.90±0.05) mm, (0.58±0.07) mm, (0.55±0.07) mm and (0.95±0.06) mm, respectively. These parameters in mongrel group were (1.27±0.07) mm, (0.92±0.05) mm, (0.59±0.06) mm, (0.67±0.07) mm and (0.94±0.05) mm, respectively. The volume of brain in two groups was (76232.33±5018.51) mm3 and (71863.96±4626.87) mm3, respectively. There were no obvious correlation among the body weight, the cerebrovascular diameters and brain

  15. Narrow, duplicated internal auditory canal

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, T. [Servico de Neurorradiologia, Hospital Garcia de Orta, Avenida Torrado da Silva, 2801-951, Almada (Portugal); Shayestehfar, B. [Department of Radiology, UCLA Oliveview School of Medicine, Los Angeles, California (United States); Lufkin, R. [Department of Radiology, UCLA School of Medicine, Los Angeles, California (United States)

    2003-05-01

    A narrow internal auditory canal (IAC) constitutes a relative contraindication to cochlear implantation because it is associated with aplasia or hypoplasia of the vestibulocochlear nerve or its cochlear branch. We report an unusual case of a narrow, duplicated IAC, divided by a bony septum into a superior relatively large portion and an inferior stenotic portion, in which we could identify only the facial nerve. This case adds support to the association between a narrow IAC and aplasia or hypoplasia of the vestibulocochlear nerve. The normal facial nerve argues against the hypothesis that the narrow IAC is the result of a primary bony defect which inhibits the growth of the vestibulocochlear nerve. (orig.)

  16. Effects of Sweet Bee Venom on cardiovascular system in the conscious telemetered Beagle Dogs

    Directory of Open Access Journals (Sweden)

    Lim Chung-San

    2010-09-01

    Full Text Available Objectives:This study was performed to analyse the effects of Sweet Bee Venom(Sweet BV on cardiovascular system in the conscious telemetered Beagle Dogs. Methods:All experiments were conducted at Biotoxtech Company, a non-clinical studies authorized institution, under the regulations of Good Laboratory Practice (GLP. Male Beagle dogs of 13-19 months old were chosen for the pilot study and surgical implantation was performed for conscious telemetered Beagle dogs. And after confirming condition of Beagle dogs was stable, Sweet BV was administered 4 times(first: 0.0 ㎎/㎏, 2nd: 0.01 ㎎/㎏, 3rd: 0.1 ㎎/㎏, and forth: 0.5 ㎎/㎏, one time/week in thigh muscle of Beagle dogs. And blood pressure, heart rate, electrocardiography and clinical responses were measured. Equal amount of normal saline to the Sweet BV experiment groups was administered to the control group. 1. In the analysis of body weight and taking amount, Beagle dogs did not show significant changes. 2. In the clinical observation, responses of pain and edema were showed depend on dosage of Sweet BV. 3. In the analysis of blood pressure, treatment with Sweet BV did not show significant changes in the dosage of 0.01 ㎎/㎏, but in the dosage of 0.1 ㎎/㎏ and 0.5 ㎎/㎏, treatment with Sweet BV increased blood pressure significantly. 4. In the analysis of heart rate, treatment of Sweet BV did not show significant changes in all dosage and period. 5. In the analysis of electrocardiography, treatment of Sweet BV was not showed significant changes in all dosage and period. Conclusion:Above findings suggest that Sweet BV is relatively safe treatment in the cardiovascular system. But in the using of over dosage, Sweet BV may the cause of increasing blood pressure. Further studies on the subject should be conducted to yield more concrete evidences.

  17. Five canalled and three-rooted primary second mandibular molar.

    Science.gov (United States)

    Selvakumar, Haridoss; Kavitha, Swaminathan; Bharathan, Rajendran; Varghese, Jacob Sam

    2014-01-01

    A thorough knowledge of root canal anatomy and its variation is necessary for successful completion of root canal procedures. Morphological variations such as additional root canals in human deciduous dentition are rare. A mandibular second primary molar with more than four canals is an interesting example of anatomic variations, especially when three of these canals are located in the distal root. This case shows a rare anatomic configuration and points out the importance of looking for additional canals. PMID:25147744

  18. Five Canalled and Three-Rooted Primary Second Mandibular Molar

    Science.gov (United States)

    Selvakumar, Haridoss; Kavitha, Swaminathan; Bharathan, Rajendran; Varghese, Jacob Sam

    2014-01-01

    A thorough knowledge of root canal anatomy and its variation is necessary for successful completion of root canal procedures. Morphological variations such as additional root canals in human deciduous dentition are rare. A mandibular second primary molar with more than four canals is an interesting example of anatomic variations, especially when three of these canals are located in the distal root. This case shows a rare anatomic configuration and points out the importance of looking for additional canals. PMID:25147744

  19. Root Canal Treatment of a Maxillary Second Premolar with Two Palatal Root Canals: A Case Report.

    Science.gov (United States)

    Golmohammadi, Maryam; Jafarzadeh, Hamid

    2016-01-01

    Accurate diagnosis of the root canal morphology and anatomy is essential for thorough shaping and cleaning of the entire root canal system and consequent successful treatment. This report describes a case of maxillary second premolar with two roots and three root canals (two mesial and distal palatal canals). The case report underlines the importance of complete knowledge about root canal morphology and possible variations, coupled with clinical and radiographic examination in order to increase the ability of clinicians to treat difficult cases. PMID:27471538

  20. Los Takanas: el acceso a la tierra y los recursos naturales (1950-2003.

    Directory of Open Access Journals (Sweden)

    Zulema Lehm Ardaya

    2010-01-01

    uso comercial de diferentes especies naturales. El artículo discute la adaptación de los takanas a los desafíos y tendencias del uso de los recursos naturales en sistemas de acceso comunitario a la tierra.

  1. Un congreso de fisica estudia la composicion de las capas de la tierra

    CERN Multimedia

    2003-01-01

    "El Congreso de Internacional de Neutrinos, que ayer comenzo en el Jardin Botanico de Valencia, aborda, entre otros aspectos, la composicion y el perfil tomografico de las distintas capas de estratos del interior de la Tierra, segun informo a Efe el profesor Jose Furtado Valle" (1/2 page).

  2. La repercusión de las transformaciones territoriales en el mercado de tierras

    OpenAIRE

    Martinoli, María Érica

    2000-01-01

    En este trabajo se indaga sobre la lógica de funcionamiento del mercado de tierras, los actores involucrados y los nuevos productos inmobiliarios derivados del actual proceso de concentración económica, exclusión social y fragmentación territorial

  3. Carcinoma of the anal canal

    International Nuclear Information System (INIS)

    There are many unresolved issues in the management of epidermoid anal canal cancer, although substantial progress has been made in gaining acceptance of techniques that preserve anal function. Resolution of the most basic questions would require formal comparisons of radical surgery, radiation therapy alone, and combined modality therapy. However, patients are unlikely to participate in studies in which one or more options would offer a chance to avoid a colostomy. Informal comparisons of published series suggest that modern radiation therapy and combined modality therapy give survival rates similar to those reported following radical surgery. Other questions being addressed include identification of optimal radiation techniques, detailed exploration of the mechanisms, efficacy, and toxicity of drug and radiation combinations, and identification of effective systemic chemotherapy. All studies are made difficult by the relative rarity of this tumor. Even without formal clinical trials, however, the series reported the use of either radiation therapy alone or combined modality therapy as the initial treatment for epidermoid anal canal carcinoma, thereby preserving anal function whenever possible and reserving radical surgery for the patient with residual carcinoma

  4. [Upper lateral incisor with 2 canals].

    Science.gov (United States)

    Fabra Campos, H

    1991-01-01

    Clinical case summary of the patient with an upper lateral incisor with two root canals. The suspicion that there might be an anatomic anomaly in the root that includes a complex root canal system was made when an advanced radicular groove was detected in the lingual surface or an excessively enlarged cingulum. PMID:1659854

  5. Cultivable Anaerobic Microbiota of Infected Root Canals

    Directory of Open Access Journals (Sweden)

    Takuichi Sato

    2012-01-01

    Full Text Available Objective. Periapical periodontitis is an infectious and inflammatory disease of the periapical tissues caused by oral bacteria invading the root canal. In the present study, profiling of the microbiota in infected root canals was performed using anaerobic culture and molecular biological techniques for bacterial identification. Methods. Informed consent was obtained from all subjects (age ranges, 34–71 years. Nine infected root canals with periapical lesions from 7 subjects were included. Samples from infected root canals were collected, followed by anaerobic culture on CDC blood agar plates. After 7 days, colony forming units (CFU were counted and isolated bacteria were identified by 16S rRNA gene sequencing. Results. The mean bacterial count (CFU in root canals was (0.5±1.1×106 (range 8.0×101–3.1×106, and anaerobic bacteria were predominant (89.8%. The predominant isolates were Olsenella (25.4%, Mogibacterium (17.7%, Pseudoramibacter (17.7%, Propionibacterium (11.9% and Parvimonas (5.9%. Conclusion. The combination of anaerobic culture and molecular biological techniques makes it possible to analyze rapidly the microbiota in infected root canals. The overwhelming majority of the isolates from infected root canals were found to be anaerobic bacteria, suggesting that the environment in root canals is anaerobic and therefore support the growth of anaerobes.

  6. 33 CFR 117.438 - Company Canal.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Company Canal. 117.438 Section 117.438 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Louisiana § 117.438 Company Canal. (a) The draw of...

  7. Una educación del acontecimiento. El Movimiento de trabajadores rurales Sin Tierra y sus pedagogías

    OpenAIRE

    Álamo Bolaños, Arminda

    2014-01-01

    La educación se da en un campo social en permanente disputa (Bourdieu). ¿Qué se disputa en Brasil con relación a la educación de campo? Antes de responder a esta pregunta, previamente, se hace necesario plantearse una nueva interrogativa: la pregunta por la Reforma Agraria. Los proyectos del MST y del gobierno de la Unión, con relación a la tierra, son inconmensurables, obedecen a lógicas distintas. El MST ve la tierra como lugar; el agronegocio, ve la tierra sin gente, solo para produc...

  8. Type III apical transportation of root canal

    Directory of Open Access Journals (Sweden)

    Shiv P Mantri

    2012-01-01

    Full Text Available Procedural accidents leading to complications such as canal transportation have been ascribed to inapt cleaning and shaping concepts. Canal transportation is an undesirable deviation from the natural canal path. Herewith a case of apical transportation of root canal resulting in endodontic retreatment failure and its management is presented. A healthy 21-year-old young male presented discomfort and swelling associated with painful endodontically retreated maxillary incisor. Radiograph revealed periradicular radiolucency involving underfilled 11 and overfilled 12. Insufficiently obturated 11 exhibited apical transportation of canal. This type III transportation was treated by periradicular surgery and repair using white mineral trioxide aggregate (MTA. Comfortable asymptomatic patient presented uneventful healing at third and fourth month recall visits. A decrease in the size of radiolucency in radiograph supported the clinical finding. In the present case, MTA is useful in repairing the transportation defect. The result of these procedures is predictable and successful.

  9. Digenea in notothenioid fish in the Beagle Channel (Magellanic sub-region, sub-Antarctica).

    Science.gov (United States)

    Jeżewski, Witold; Zdzitowiecki, Krzysztof; Laskowski, Zdzisław

    2014-03-01

    Fish of five species of Notothenioidei (104 specimens), Cottoperca trigloides, Patagonotothen brevicauda, P. longipes, P. tessellata and Champsocephalus esox, caught in the Beagle Channel (Magellanic sub-region, sub-Antarctica) were infected with Digenea of nine species (1130 specimens). Faunistic data on the occurrence of all nine parasites are provided. The most abundant digenean species was Macvicaria magellanica found in the intestine of three host species of the genus Patagonotothen. The second most abundant digenean species was Elytrophalloides oatesi found in the stomach of four host species, with exception of P. brevicauda. Three digenean species: Stenakron kerguelense, Whitegonimus ozoufae and Genolinea bowersi, were more abundant in fish caught at the harbor of Ushuaia (depth 7-9 m), remaining six species: M. magellanica, Neolepidapedoides subantarcticus, Postmonorchis variabilis, Derogenes varicus, E. oatesi and Lecithaster macrocotyle, in the eastern mouth of the Beagle Channel (depth 30 m). PMID:24570049

  10. Mechanical and morphological evaluation of age-related changes in the Beagle spine

    International Nuclear Information System (INIS)

    Age-related changes were evaluated in the spines of Beagle dogs by biomechanical testing, radiology and pathology. Thirty age-matched healthy Beagle dogs were divided into five groups having mean ages of 2, 5, 8, 11, and 14 years. Spinal radiographs of anesthetized dogs were taken prior to euthanasia and on defleshed pines following necropsy. Cervical, thoracic, and lumbar segments were tested in compression to calculate peak stress, peak strain, and elastic modulus. Adjacent spinal segments were examined histologically. Histological evidence of the disc degeneration and changes in the mechanical properties of the intervertebral disc joint preceded radiographical evidence of spondylosis. Changes in the mechanical properties of the disc space were probably a result of the disc degeneration rather than the spondylytic lesions. 3 references, 4 figures

  11. MRI Findings in Spinal Canal Stenosis

    Directory of Open Access Journals (Sweden)

    Maryam Barzin

    2010-05-01

    Full Text Available Spinal canal stenosis results from progressive narrowing of the central spinal canal and the lateral recesses. Primary (congenital lumbar spinal stenosis is associated with achondroplastic dwarfism. The spinal canal may become narrowed by bulging or protrusion of the intervertebral disc annulus, herniation of the nucleus pulposus posteriorly, thickening of the posterior longitudinal ligament, hypertrophy of the facet joints, hypertrophy of the ligamentum flavum, epidural fat deposition, spondylosis of the intervertebral disc margins and uncovertebral joint hypertrophy in the neck. The central canal and the neurorecess may be compromised by tumor infiltration, such as metastatic disease, or by infectious spondylitis."nAP diameter of the normal adult cervical canal has a mean value of 17-18 mm at vertebral levels C3-5. The lower cervical canal measures 12-14 mm. Cervical stenosis is associated with an AP diameter of less than 10 mm. The thoracic spinal canal varies from 12 to 14 mm in diameter in the adult. The diameter of the normal lumbar spinal canal varies from 15 to 27 mm. Lumbar stenosis results from a spinal canal diameter of less than 12 mm in some patients; a diameter of 10 mm is definitely stenotic."nSpinal MRI is the most suitable technique for the diagnosis of spinal stenosis. The examination should be performed using thin sections (3 mm and high resolution, including the axial and sagittal planes using T1-weighted, proton-density, and T2-weighted techniques. The bony and osteophytic components are seen best using a T2-weighted gradient-echo technique."nOn MRI, findings of spinal stenosis have a variable presentation depending on the specific disease. The goal of spinal imaging is to localize the site and level of disease and to help differentiate between conditions in which patients require surgery or conservative treatment."nIn this presentation, different kinds of spinal canal stenosis and their MRI findings would be discussed.

  12. Non-neoplastic pulmonary disease from inhaled radon daughters with uranium ore dust in beagle dogs

    International Nuclear Information System (INIS)

    Daily exposures of adult beagle dogs to inhaled radon daughters plus uranium ore dust, with and without concurrent cigarette smoking, for 2 to 5-1/2 yr have produced massive pulmonary fibrosis and severe emphysema. The cumulative exposure doses are similar to those associated with a 5-fold or greater increase in death rate of uranium miners due to chronic respiratory insufficiency, including pneumoconiosis, pulmonary fibrosis, and emphysema

  13. Early effects of inhaled 239Pu(NO3)4 aerosols in beagle dogs

    International Nuclear Information System (INIS)

    Beagle dogs given a single inhalation exposure to 239Pu(NO3)4, and observed for life-span dose-effect relationship, died from radiation pneumonitis (4 of 5) at the highest dosage level, 14 to 25 mo postexposure. There were also indications in these dogs of radiation osteosis, characterized by peritrabecular fibrosis. Leukopenia, lymphopenia, neutropenia and decreased numbers of circulating monocytes and eosinophils occurred at the two highest dosage levels, as previously reported

  14. Histomorphometry and stability analysis of early loaded implants with two different surface conditions in beagle dogs

    OpenAIRE

    Kim, Dong-Seok; Kim, Dae-Gon; Park, Chan-Jin; Cho, Lee-Ra

    2009-01-01

    STATEMENT OF PROBLEM Despite an improved bone reactions of Mg-incorporated implants in the animals, little yet has been carried out by the experimental investigations in functional loading conditions. PURPOSE This study investigated the clinical and histologic parameters of osseointegrated Mg-incorporated implants in early loading conditions. MATERIAL AND METHODS A total of 36 solid screw implants (diameter 3.75 mm, length 10 mm) were placed in the mandibles of 6 beagle dogs. Test groups incl...

  15. Tissue Doppler and strain imaging of left ventricle in Beagle dogs with iatrogenic hypercortisolism

    OpenAIRE

    OUI, Heejin; JEON, Sunghoon; LEE, Gahyun; Park, Seungjo; Cho, Kyoung-Oh; Choi, Jihye

    2015-01-01

    Changes in radial and longitudinal left ventricular (LV) function were investigated in beagles with iatrogenic hypercortisolism. A total of 11 normal dogs were used, and 2 mg/kg prednisone was administered per oral q12 h for 28 days to 7 out of 11 dogs to induce iatrogenic hypercortisolism. Body weight, blood pressure, conventional echocardiography and tissue Doppler imaging (TDI) of normal and iatrogenic hypercortisolism groups were conducted. The myocardial wall velocity of the LV was measu...

  16. Late effects of inhaled 238PuO2 in beagles

    International Nuclear Information System (INIS)

    Bone tumors were the primary cause of death in beagle dogs 4 to 6 years after inhalation of 238PuO2. The plutonium body burden at death ranged from 0.5 to 2.6 μCi with 32 to 55 percent of the plutonium in the skeleton. Pulmonary neoplasia was observed in three of the bone-tumor-bearing dogs. (U.S.)

  17. Retention and distribution of 226Ra in beagles: a comparison between multiple and single injections

    International Nuclear Information System (INIS)

    Skeletal uptake, retention, and distribution of 226Ra were studied in 330 beagles administered eight semi-monthly i.v. injections of radium starting at 2, 4, and 14 months of age. Skeletal uptake, the ratio of body burden at 35 days post-injection (A35) to the total injected dose (A0) was 71.7 percent, 78.1 percent and 38.5 percent, for a dose of 10 μCi/kg body weight administered starting at 2, 4, and 14 months of age, respectively. Skeletal retention of radium 350 days post-injection (A350/A0) was 67.2 percent, 73.3 percent, and 27.7 percent. Comparison of 226Ra retention from single and multiple injections of radium shows that at dose level 6.064 μCi/kg the retention functions for periods 35 days after injection are identical; for dose level 10 μCi/kg, a larger retention is observed for multiple-injection groups. Comparison of 226Ra retention in man with that in beagles shows that within a period between 35 days and 6000 days post--injection, the body burden in dog decreases by about 6 times in contrast with 43 times in man. Regional distribution of 226Ra in bone matrix at proximal, midshaft, and distal humeri from 21 beagles shows the highest concentration of the radionuclide at proximal regions. Radium distribution on autoradiograms shows a uniform distribution in 4-month-old beagles in contrast to ''hot spots'' superimposed on a diffuse background for the 14-month age group. Radium in the latter group is located mostly on periosteum and endosteum surfaces

  18. Identification of Matrix Metalloproteinase-2 and -9 Activities within Intestinal Mucosa of Clinically Healthy Beagle Dogs

    OpenAIRE

    Hanifeh, Mohsen; Rajamäki, Minna M.; MÄKITALO, Laura; Syrjä, Pernilla; Sankari, Satu; Kilpinen, Susanne; Spillmann, Thomas

    2014-01-01

    ABSTRACT Matrix metalloproteinases (MMPs) 2 and 9 are zinc-dependent endopeptidases that contribute to the control of breakdown and reconstitution of extracellular matrix under both normal and pathological conditions. The main objective of this study was to identify the presence of MMP-2 and -9 in the mucosa of the small and large intestines of clinically healthy beagle dogs using gelatin zymography technique. Intestinal mucosa samples from four different parts of the intestine (duodenum, jej...

  19. Pharmacokinetics of Ginkgolide B after Oral Administration of Three Different Ginkgolide B Formulations in Beagle Dogs

    Directory of Open Access Journals (Sweden)

    Jie Zhao

    2015-11-01

    Full Text Available Ginkgolide B (GB, an important active constituent of Ginkgo biloba extract, has been used in clinical applications for the treatment of dementia, cerebral insufficiency or related cognitive decline. To investigate the main pharmacokinetic characteristics of three different GB formulations in beagle dogs, a simple, specific and sensitive LC-MS/MS method was established and validated. The separation of the analytes was achieved on an Agilent Eclipse Plus C18 column (1.8 μm, 2.1 × 50 mm with a mobile phase consisting of water and acetonitrile. The flow rate was set at 0.4 mL/min. Quantitation was performed using multiple reaction monitoring (MRM in negative ion mode, with the transitions at m/z (Q1/Q3 423.1/367.1 for GB and m/z 269.3/170.0 for IS. The linear calibration curve of GB was obtained over the concentration range of 2–200 ng/mL. The intra- and inter-day precisions were <15% and the accuracies were within ±12.7%. The validated method was applied to compare the pharmacokinetic characteristics of GB in healthy beagle dogs after oral administration of three formulations (HME08, GB capsule prepared by hot-melt extrusion technology; LL06, GB pellet prepared by liquid layer technology; conventional GB tablet. The Cmax values of GB from different formulations in beagle dog plasma were 309.2, 192.4 and 66.6 µg/L, and the AUC values were 606.7, 419.1 and 236.2 µg/L·h, respectively. The data suggested that the exposure level of GB from HME08 and LL06 in beagle dog plasma was greatly improved compared with conventional tablets. This study should be helpful for the design and development of oral GB preparations.

  20. Survey of blood pressure in 226Ra- and 90Sr-treated beagles

    International Nuclear Information System (INIS)

    Multiple blood pressure measurements on a total of 407 beagles with a non-invasive method showed the greatest frequency of mean pressures to be in the normal 101-120 mm Hg range. Another major group of dogs were hypertensive, with mean pressures of 120-140 mm Hg. Future correlation of canine blood pressures with diseases should prove useful in both veterinary and human medical research

  1. Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs.

    Science.gov (United States)

    Wang, Wusan; Ji, Hui; Li, Tingting; Jia, Yuanwei; Xie, Haitang

    2016-06-01

    A pharmacokinetic comparison and conformational stability study of S-oxiracetam (S-ORT) and R-oxiracetam (R-ORT) in beagle dogs was used to investigate the possible mechanism of different effects of two oxiracetam enantiomers through a random crossover design. After drug administration to beagle dogs, blood samples were collected at different time points for pharmacokinetic analysis using the UPLC-ESI-MS/MS method. Parts of plasma samples were used for conformation transformation studies using a normal phase high performance liquid chromatographic (NP HPLC) method. The study showed that oxiracetam enantiomers maintained their original conformation when administered orally to beagle dogs. Concentrations of S-ORT were significantly higher than R-ORT 1.5 and 2 h after administration; the AUC0-∞ of S-ORT after oral administration tended to be higher than that of R-ORT, which showed that the different effects between S-ORT and R-ORT may be partly associated with their distinctive absorption at least. PMID:27279070

  2. Charles Darwin's beagle voyage, fossil vertebrate succession, and "the gradual birth & death of species".

    Science.gov (United States)

    Brinkman, Paul D

    2010-01-01

    The prevailing view among historians of science holds that Charles Darwin became a convinced transmutationist only in the early spring of 1837, after his Beagle collections had been examined by expert British naturalists. With respect to the fossil vertebrate evidence, some historians believe that Darwin was incapable of seeing or understanding the transmutationist implications of his specimens without the help of Richard Owen. There is ample evidence, however, that he clearly recognized the similarities between several of the fossil vertebrates he collected and some of the extant fauna of South America before he returned to Britain. These comparisons, recorded in his correspondence, his diary and his notebooks during the voyage, were instances of a phenomenon that he later called the "law of the succession of types." Moreover, on the Beagle, he was following a geological research agenda outlined in the second volume of Charles Lyell's Principles of Geology, which implies that paleontological data alone could provide an insight into the laws which govern the appearance of new species. Since Darwin claims in On the Origin of Species that fossil vertebrate succession was one of the key lines of evidence that led him to question the fixity of species, it seems certain that he was seriously contemplating transmutation during the Beagle voyage. If so, historians of science need to reconsider both the role of Britain's expert naturalists and the importance of the fossil vertebrate evidence in the development of Darwin's ideas on transmutation. PMID:20665232

  3. Incidence of liver tumors in beagles with body burdens of 239Pu or 241Am

    International Nuclear Information System (INIS)

    Tetravalent 239Pu or trivalent 241Am in a citrate buffer, given via a single intravenous injection to beagles, induced very pronounced liver changes, usually at relatively long postinjection times. The lesions consisted of cell injury or cell necrosis which was followed by nodular hyperplasia and a significant incidence of primary liver tumors. The most frequent neoplasm was the bile duct adenoma, followed by the bile duct carcinoma. A lesser number of sarcomas were also induced, especially fibrosarcomas. The number of hepatic cell tumors was low. An abnormally high incidence of both hyperplastic nodules and primary liver tumors occurred at long postinjection times and at average doses extending down to ∼10 rads. The various nodular lesions and liver tumors frequently occurred as incidental findings in dogs dying from other causes, especially bone cancer. In comparison to bone neoplasia, the liver was a much less important target organ in the high-dose level groups, but in some of the low-dose groups, especially in the 241Am groups, the risk of radiation-induced liver cancer was approximately equal to or exceeded the risk of skeletal tumors. However, in any projection of the risks observed in this animal model to man, one should be mindful that the beagle skeleton is approximately 25 times more sensitive to radiation-induced bone neoplasia than is the human skeleton (Mays et al., 1976) and that the radiosensitivity difference for the beagle and human liver is unknown. 41 refs., 8 figs., 5 tabs

  4. Analysis of acamprosate in beagle dog plasma by LC-MS-MS.

    Science.gov (United States)

    Rhee, Yun-Seok; Park, Jeong-Hwa; Park, Seok; Park, Chun-Woong; Ha, Jeong-Myung; Jeong, Ki-Woo; Lee, Dong-Soo; Park, Eun-Seok

    2008-08-01

    A rapid, sensitive, and specific analytical method was developed and validated to quantify acamprosate calcium in beagle dog plasma. The method employs a single plasma protein precipitation, and the analytes are separated by chromatography on an Acquity UPLC HSS T3 column and analyzed by mass spectrometry in the multiple reaction monitoring (MRM) mode. The method has a chromatographic run time of 1.25 min and a linear calibration curve over the range 200-10000 ng/mL (r(2)>0.9994). The intra-day and inter-day accuracy and precision were within 10.0% for the analyte. Acamprosate was stable during all sample storage, preparation, and analytical periods. This method was employed in a pharmacokinetic study of an acamprosate 333 mg enteric-coated tablet in 8 male beagle dogs that received single 666 mg doses (333 mg x 2 tablets). The proposed method enables identification and quantification in pharmacokinetic studies of acamprosate in beagle dog plasma. PMID:18787794

  5. Pharmacokinetics study of extended release formulations of buspirone hydrochloride in Beagle dogs

    Institute of Scientific and Technical Information of China (English)

    CUI Meng-cun; LI Jing-lai; CHEN Yan; WANG Xiao-ying; QIAO Jian-zhong; ZHANG Zhen-qing; RUAN Jin-xiu

    2008-01-01

    Objective To evaluate the pharmacokinetics (PK) properties of extended release formulations of buspirone hydrochloride in Beagle dogs. Methods A randomized, two period, two treatment, two sequence crossover bioequivalenee study was designed; six healthy Beagle dogs were randomly divided into two groups, each group was orally given buspirone tablets or buspirone extended capsule containing 15 mg buspirone hydrochloride. Blood samples (about 1 mL) were collected in heparinized tubes before dosing and at 0.33, 0.67, 1,2, 3, 4, 6, 8, 10, 12, 18, 24 h after administration, and were then immediately centrifuged at 3000 rpm for 15 min. The pharmacokinetics (PK) properties of the drugs were evaluated using the liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method. Results The mean tmax was 4.7, 0.8 h and Cmax values was 1.8, 6.9 μg·L-1, respectively for the sustained-release test (capsule) and reference formulation (tablet). When compared to the tablets, the residence time of the sustained capsules was dramatically prolonged and Cmax Was reduced (P<0.01). The initial release speed was slow and stable. The bioavailability was similar to the common tablets. Conclusions The sustained capsule had showed good pharmacokinetics property of sustained-release in the Beagle dogs.

  6. An experimental approach for archeological soil micromorphology: building a model for site taphonomy in coastal shell middens of the Beagle Channel (Argentina)

    Science.gov (United States)

    Balbo, Andrea; Suarez Villagran, Ximena; Madella, Marco; Vila, Asumpcio; Estevez, Jordi

    2010-05-01

    There are still many archaeological contexts where soil micromorphology has been little applied. Examples of such are anthropic shell deposits, common in coastal settings worldwide. These archaeological sites have complex stratigraphies composed mainly of shell from diverse species of local mollusks and gastropods. They have the peculiarity of being highly porous sediments with a coarse fraction that is dominated by gravel-sized bioclastic remains (shell, fish bones) and a fine fraction composed of organic material (charcoal, organic matter). The use of soil micromorphology in shell deposits was started by the Spanish-Argentinean research team working in Tierra del Fuego (Argentina) since 1986. This project focused on excavation of hunter-gatherer sites from the contact period. One of the main objectives was to develop a detailed excavation method for shell middens that maximized the amount of recorded data during archaeological excavation. In this perspective, microstratigraphy was conceived as a fundamental complement for the study of site formation processes, as it would provide with high definition data for identification of shell accumulation episodes, trampling on site, abandonment periods, taphonomic alterations etc. A reference collection of known environmental and anthropic control features, such as hearths, trampling areas, wood ashes from local species, among others, was built to help in the microscopic characterization of archaeological samples. In this work, we analyze this experimental collection and compare it with samples from the Tunel VII archaeological site, located in the northern coast of the Beagle Channel and dated from the 18th-19th centuries. The set of modern samples included: trampling area from an animal pathway; beach deposit; forest litter; soil under the forest; hearths lit in diverse contexts (on the prairie, the beach and from the archaeologist camp site); and experimental burnt valves of Mytilus edulis, the main malacological

  7. Carcinoma of the anal canal

    Directory of Open Access Journals (Sweden)

    David T. Marshall

    2011-12-01

    Full Text Available There are around 5,000 new cases of anal canal cancer each year in the United States. It is of particular risk in HIV-positive populations. Many cases are related to persistent infection with human papillomavirus (HPV. The treatment of anal cancer has progressed from abdominoperineal resection mandating permanent colostomy in the 1940s through the 1970s to modern chemoradiation with sphincter preservation in around 80% of patients, even with locally advanced disease. The evolution of the treatment paradigm of this disease is a model for the treatment of malignant disease with organ preservation. Multiple randomized trials have been conducted to guide this evolution. Technological developments in the delivery of radiotherapy and anti-cancer pharmaceuticals harbor hope for further improvements in outcomes with possible reductions in toxicity and increases in tumor control. Perhaps most inspiring is the recent development of HPV vaccines that

  8. Taenia saginata Goeze, 1872 (Platyhelminthes: Cestoda: Taeniidae) from an indigenous native from Tierra del Fuego, Chile

    OpenAIRE

    Eduardo I. Faúndez; Máriom A. Carvajal

    2015-01-01

    First record of Taenia saginata from an indigenous from Tierra del Fuego (Chilean Patagonia) is reported, from museum material of the year 1902. The importance of the record is discussed. Illustrations of the specimen are given.

  9. Panama Canal Watershed Experiment- Agua Salud Project

    Science.gov (United States)

    Stallard, Robert F.; Ogden, Fred L.; Elsenbeer, Helmut; Hall, Jefferson S.

    2010-01-01

    The Agua Salud Project utilizes the Panama Canal’s (Canal) central role in world commerce to focus global attention on the ecosystem services provided by tropical forests. The Canal was one of the great engineering projects in the world. Completed in 1914, after almost a decade of concerted effort, its 80 km length greatly shortened the voyage between the Atlantic and Pacific Oceans. An entire class of ships, the Panamax, has been constructed to maximize the amount of cargo that can be carried in a Canal passage. In today’s parlance, the Canal is a “green” operation, powered largely by water (Table 1). The locks, three pairs on each end with a net lift of 27 meters, are gravity fed. For each ton of cargo that is transferred from ocean to ocean, about 13 tons of water (m3) are used. Lake Gatún forms much of the waterway in the Canal transect. Hydroelectricity is generated at the Gatún dam, whenever there is surplus water, and at Madden Dam (completed in 1936) when water is transferred from Lake Alhajuela to Lake Gatún. The Canal watershed is the source of drinking water for Panama City and Colon City, at either end of the Canal, and numerous towns in between.

  10. How to bond to root canal dentin

    Science.gov (United States)

    Nica, Luminita; Todea, Carmen; Furtos, Gabriel; Baldea, Bogdan

    2014-01-01

    Bonding to root canal dentin may be difficult due to various factors: the structural characteristic of the root canal dentin, which is different from that of the coronal dentin; the presence of the organic tissue of the dental pulp inside the root canal, which has to be removed during the cleaning-shaping of the root canal system; the smear-layer resulted after mechanical instrumentation, which may interfere with the adhesion of the filling materials; the type of the irrigants used in the cleaning protocol; the type of the sealer and core material used in the obturation of the endodontic space; the type of the materials used for the restoration of the endodontically treated teeth. The influence of the cleaning protocol, of the root canal filling material, of the type of the adhesive system used in the restoration of the treated teeth and of the region of the root canal, on the adhesion of several filling and restorative materials to root canal dentin was evaluated in the push-out bond strength test on 1-mm thick slices of endodontically treated human teeth. The results showed that all these factors have a statistically significant influence on the push-out bond strength. Formation of resin tags between radicular dentin and the investigated materials was observed in some of the samples at SEM analysis.

  11. 21 CFR 872.3810 - Root canal post.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Root canal post. 872.3810 Section 872.3810 Food... DEVICES DENTAL DEVICES Prosthetic Devices § 872.3810 Root canal post. (a) Identification. A root canal... of the platinum group intended to be cemented into the root canal of a tooth to stabilize and...

  12. The relapses of cancerous growths of anal canal

    International Nuclear Information System (INIS)

    In this chapter of book authors give information about general comprehensions of the relapses of anal canal cancerous growths, the classification of the relapses of anal canal cancerous growths, frequency of the relapses of anal canal cancerous growths, the diagnostics of the relapses of anal canal cancerous growths and prophylaxis and treatment of relapses

  13. Pobreza, agua y tierra en Ambato, Ecuador: Perfil de pobreza y el acceso y manejo de agua y tierra en la cuenca de Ambato, Ecuador

    OpenAIRE

    Chapalbay, Washington; Cordero, Doris; Gómez, Ligia Ivette; Munk Ravnborg, Helle

    2007-01-01

    Este informe tiene coma objetivo presentar el perfil de pobreza para la cuenca del rio Ambato, la prov1ncia de Tungurahua, Ecuador, )' analizar en que medida el acceso al agua, particularmente para el riego, ya la tierra, depende de los niveles de pobreza. El manejo del agua es clave en la cuenca de Ambato, principalmente para la producci6n agricola. Con base en el perEl de pobreza, casi dos terceras partes de las familias tienen acceso al riego. De la misma forma, casi la totalidad de las fa...

  14. Primeros ensayos petrofísicos sobre la roca dimensional de Tierra del Fuego First petrophysical trials over dimension stones of Tierra del Fuego

    OpenAIRE

    Rogelio Daniel Acevedo; Mauricio González-Guillot

    2011-01-01

    Se muestran aquí los primeros ensayos de laboratorio sobre las rocas dimensionales de Tierra del Fuego, región que tenía una potencialidad no evaluada respecto al uso posible de este recurso nativo. Nunca habían sido empleadas hasta ahora rocas duras (ígneas) ni pizarras en la construcción residencial, el revestimiento de fachadas ó pisos. Dos pequeñas canteras de rocas plutónicas han sido abiertas recientemente: una de ellas en el cerro Jeu-Jepén, aprovechada para la construcción de la escol...

  15. Análisis tafonómico en La Arcillosa 2 (Tierra del Fuego, Argentina) Taphonomic analysis of La Arcillosa 2 site, Tierra del Fuego, Argentina

    OpenAIRE

    Fernando C. Santiago

    2007-01-01

    En este trabajo se presenta el análisis tafonómico de los restos arqueofaunísticos y bioarqueológicos recuperados en el sitio La Arcillosa 2 (Tierra del Fuego). El mismo es un sitio multicomponente con fechados radiocarbónicos del Holoceno medio. Se discuten las características de estos dos conjuntos de huesos en particular y se comparan los resultados con datos tafonómicos generados en otros sitios arqueológicos de la isla. La evaluación del efecto de los factores de formación del registro e...

  16. Epidemiología de las lesiones por mordedura de perro en Tierra del Fuego, Argentina Epidemiology of dog bite lesions in Tierra del Fuego, Argentina

    OpenAIRE

    Fabián Zanini; Patricia Padinger; María C. Elissondo; Héctor Pérez

    2008-01-01

    La convivencia del hombre y el perro ha resultado en beneficios mutuos durante miles de años, si bien en el último tiempo han surgido una serie de inconvenientes donde las lesiones por mordeduras ocupan un lugar destacado. El objetivo del presente trabajo fue describir las características epidemiológicas de las lesiones por mordedura de perro ocurridas a lo largo de un año en Tierra del Fuego. Se realizó un estudio observacional descriptivo, transversal, de los pacientes que ingresaron con le...

  17. Restos humanos en el norte de Tierra del Fuego: Aspectos contextuales, dietarios y paleopatológicos Human remains in northern Tierra del Fuego : context, diet and paleopathology

    OpenAIRE

    Santiago Fernando; Mónica Salemme; Jorge Suby; Ricardo Guichón

    2011-01-01

    Una serie de excavaciones realizadas entre los años 2000 y 2007 en la costa atlántica de Tierra del Fuego, en su mayoría de rescate, permitieron recuperar 11 esqueletos humanos en ocho sitios en contextos mortuorios de apariencia diversa. Se presenta y discute aquí la información referida a la distribución de este registro, considerando el tipo de entierro, los procesos posdepositacionales que probablemente actuaron sobre el registro bioarqueológico, las características paleopatológicas y los...

  18. Hifomicetes lignícolas de Tierra del Fuego (Fungi, Fungi Imperfecti, Hyphomycetales) Hyphomycetes from Tierra del Fuego (Fungi, Fungi Imperfecti, Hyphomycetales)

    OpenAIRE

    A. M. Godeas; Arambarri, A. M.

    2007-01-01

    En este trabajo se investiga los hifomicetes en los bosques de Tierra del Fuego, que crecen sobre madera y corteza en diferentes estados de descomposición. Se incluye una clave de los géneros encontrados y cuando fue necesario una clave de las especies. Se identificaron 39 especies de las cuales 18 son primeras citas para la Argentina. Se realizan algunas consideraciones acerca de su importancia en el ecosistema.In this work, diversity and ditribution of Hyphomycetes growing in bark and wood ...

  19. Scanning electron microscopy investigation of canal cleaning after canal preparation with nickel titanium files

    Directory of Open Access Journals (Sweden)

    Živković Slavoljub

    2010-01-01

    Full Text Available Introduction. Root canal preparation is the most important phase of endodontic procedure and it consists of adequate canal space cleaning and shaping. In recent years, rotary instruments and techniques have gained importance because of the great efficacy, speed and safety of the preparation procedure. Objective. The aim of this research was to investigate the influence of different NiTi files on the canal wall cleaning quality, residual dentine debris and smear layer. Methods. The research was conducted on extracted human teeth in vitro conditions. Teeth were divided in 7 main groups depending on the kind of instruments used for root canal preparation: ProTaper, GT, ProFile, K-3, FlexMaster, hand ProTaper and hand GT. Root canal preparation was accomplished by crown-down technique. Prepared samples were assessed on scanning electron microscopy JEOL, JSM-6460 LV. The evaluation of dentine debris was done with 500x magnification, and the evaluation of smear layer with 1,000 times magnification. Quantitive assessment of dentine debris and smear layer was done according to the criteria of Hulsmann. Results. The least amount of debris and smear layer has been found in canals shaped with ProFile instruments, and the largest amount in canals shaped with FlexMaster instruments. Canal cleaning efficacy of hand GT and ProTaper files has been similar to cleaning efficacy of rotary NiTi files. Statistic analysis has shown a significant difference in amount of dentine debris and smear layer on the canal walls between sample groups shaped with different instruments. Conclusion. Completely clean canals have not been found in any tested group of instruments. The largest amount of debris and smear layer has been found in the apical third of all canals. The design and the type of endodontic instruments influence the efficacy of the canal cleaning.

  20. Comparison of Bacterial Leakage between 3 Different Root Canal Obturation Techniques in Oval Shaped Canals

    OpenAIRE

    Eshagh-ali Saberi; Shahram Shahraki; Sediqe Ebrahimipour; Anousheh Rashed Mohassel; Narjes Akbari; Majid Rezaei

    2014-01-01

    Introduction: The purpose of this study was to evaluate the sealing ability of 3 obturation techniques in oval-shaped canals by bacterial leakage assessment. Methods: Sixty mandibular incisors with oval canals were selected after providing buccolingual and mesiodistal radiographs. The teeth were sectioned at a 10 mm distance from the apex. After instrumentation, the teeth were divided into 3 groups and the canals in the three groups were obturated with lateral condensation (G1), warm vertical...

  1. SU-C-303-03: Dosimetric Model of the Beagle Needed for Pre-Clinical Testing of Radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Shang, M; Sands, M; Bolch, W [University of Florida, Gainesville, FL (United States)

    2015-06-15

    Purpose: Large animal models, most popularly beagles, have been crucial surrogates to humans in determining radiation safety levels of radiopharmaceuticals. This study aims to develop a detailed beagle phantom to accurately approximate organ absorbed doses for therapy nuclear medicine preclinical studies. Methods: A 3D NURBS model was created subordinate to a whole body CT of an adult beagle. Bones were harvested and CT imaged to offer macroscopic skeletal detail. Samples of trabecular spongiosa were cored and imaged to offer microscopic skeletal detail for bone trabeculae and marrow volume fractions. Results: Organ masses in the model are typical of an adult beagle. Trends in volume fractions for skeletal dosimetry are fundamentally similar to those found in existing models of other canine species. Conclusion: This work warrants its use in further investigations of radiation transport calculation for electron and photon dosimetry. This model accurately represents the anatomy of a beagle, and can be directly translated into a useable geometry for a voxel-based Monte Carlo radiation transport program such as MCNP6. Work supported by a grant from the Hyundai Hope on Wheels Foundation for Pediatric Cancer Research.

  2. Spectral variability on primitive asteroids of the Themis and Beagle families: space weathering effects or parent body heterogeneity?

    CERN Document Server

    Fornasier, S; Perna, D; Campins, H; Barucci, M A; Nesvorny, D

    2016-01-01

    Themis is an old and statistically robust asteroid family populating the outer main belt, and resulting from a catastrophic collision that took place 2.5$\\pm$1.0 Gyr ago. Within the old Themis family a young sub-family, Beagle, formed less than 10 Myr ago, has been identified. We present the results of a spectroscopic survey in the visible and near infrared range of 22 Themis and 8 Beagle families members. The Themis members investigated exhibit a wide range of spectral behaviors, while the younger Beagle family members look spectrally bluer with a smaller spectral slope variability. The best meteorite spectral analogues found for both Themis and Beagle families members are carbonaceous chondrites having experienced different degrees of aqueous alteration, prevalently CM2 but also CV3 and CI, and some of them are chondrite samples being unusual or heated. We extended the spectral analysis including the data available in the literature on Themis and Beagle families members, and we looked for correlations betwe...

  3. SU-C-303-03: Dosimetric Model of the Beagle Needed for Pre-Clinical Testing of Radiopharmaceuticals

    International Nuclear Information System (INIS)

    Purpose: Large animal models, most popularly beagles, have been crucial surrogates to humans in determining radiation safety levels of radiopharmaceuticals. This study aims to develop a detailed beagle phantom to accurately approximate organ absorbed doses for therapy nuclear medicine preclinical studies. Methods: A 3D NURBS model was created subordinate to a whole body CT of an adult beagle. Bones were harvested and CT imaged to offer macroscopic skeletal detail. Samples of trabecular spongiosa were cored and imaged to offer microscopic skeletal detail for bone trabeculae and marrow volume fractions. Results: Organ masses in the model are typical of an adult beagle. Trends in volume fractions for skeletal dosimetry are fundamentally similar to those found in existing models of other canine species. Conclusion: This work warrants its use in further investigations of radiation transport calculation for electron and photon dosimetry. This model accurately represents the anatomy of a beagle, and can be directly translated into a useable geometry for a voxel-based Monte Carlo radiation transport program such as MCNP6. Work supported by a grant from the Hyundai Hope on Wheels Foundation for Pediatric Cancer Research

  4. Boolean nested canalizing functions: a comprehensive analysis

    CERN Document Server

    Li, Yuan; Murrugarra, David; Aguilar, Boris; Laubenbacher, Reinhard

    2012-01-01

    Boolean network models of molecular regulatory networks have been used successfully in computational systems biology. The Boolean functions that appear in published models tend to have special properties, in particular the property of being nested canalizing, a property inspired by the concept of canalization in evolutionary biology. It has been shown that networks comprised of nested canalizing functions have dynamic properties that make them suitable for modeling molecular regulatory networks, namely a small number of (large) attractors, as well as relatively short limit cycles. This paper contains a detailed analysis of this class of functions, based on a novel normal form as polynomial functions over the Boolean field. The concept of layer is introduced that stratifies variables into different classes depending on their level of dominance. Using this layer concept a closed form formula is derived for the number of nested canalizing functions with a given number of variables. Additional metrics analyzed in...

  5. Five Canalled and Three-Rooted Primary Second Mandibular Molar

    OpenAIRE

    Haridoss Selvakumar; Swaminathan Kavitha; Rajendran Bharathan; Jacob Sam Varghese

    2014-01-01

    A thorough knowledge of root canal anatomy and its variation is necessary for successful completion of root canal procedures. Morphological variations such as additional root canals in human deciduous dentition are rare. A mandibular second primary molar with more than four canals is an interesting example of anatomic variations, especially when three of these canals are located in the distal root. This case shows a rare anatomic configuration and points out the importance of looking for addi...

  6. Design of earth network in electric substations; Diseno de redes de tierra en subestaciones electricas

    Energy Technology Data Exchange (ETDEWEB)

    Raull-Martin, J. [Universidad Nacional Autonoma de Mexico, Mexico, D.F. (Mexico)

    2000-09-01

    The purpose of this paper is to present a summarized version of the different types of construction of grounding systems, as web as their materials and formulas, which are necessary and useful for the design and building of a grounding network for medium to high voltage facilities. A description is also made of how to determine the electrical resistivity of subsoil layers with different physical characteristics. Several illustrative examples are also solved in the paper. [Spanish] El proposito de este articulo es presentar de manera resumida los diferentes tipos de construccion de los sistemas de tierra, asi como sus materiales y formulas, los cuales son necesarios y utiles para el diseno y edificacion de una red de tierra para instalaciones de mediana y alta tension. Se describe tambien la obtencion de las diferentes resistividades que presentan los terrenos con diversas caracteristicas fisicas. Asi mismo, se solucionan ejercicios ilustrativos a lo largo del articulo.

  7. Desplazamiento forzado y propiedad de la tierra en Antioquia, 1996-2004

    Directory of Open Access Journals (Sweden)

    Carlos Felipe Gaviria

    2007-06-01

    Full Text Available El desplazamiento forzoso es un fenómeno mundial que ha acompañado crisis políticas y sociales, relacionado, además, con el dominio del territorio por parte de los grupos inmersos en el conflicto. En Colombia, este fenómeno social se ha incrementado en los últimos años, junto con problemas agrarios, sociales y productivos. El objetivo de este artículo es analizar la relación existente entre el desplazamiento forzado y los procesos de concentración de la tierra en Antioquia entre 1996-2004. Se encuentra que existe una relación positiva entre propiedad de la tierra y desplazamiento forzado; en especial en Urabá y Oriente, subregiones antioqueñas con la producción agrícola más importante.

  8. Do crustal deformations observed by GPS in Tierra del Fuego (Argentina reflect glacial-isostatic adjustment?

    Directory of Open Access Journals (Sweden)

    L. Mendoza

    2010-09-01

    Full Text Available Vertical site velocities determined by geodetic GPS observations in the Lago Fagnano area, Tierra del Fuego main island, are interpreted with respect to their potential relation with the glacial-isostatic crustal response to ice mass changes. The spatial pattern of the uplift rates, in combination with the horizontal crustal deformation pattern, point towards a fault-tectonic rather than glacial-isostatic origin of the determined vertical crustal deformations. This implies rather small GIA effects pointing towards relatively small Holocene ice-mass changes in Tierra del Fuego. However, these findings are considered to be preliminary. They should be confirmed by additional observations covering an extended area with GPS sites.

  9. Squamous cell carcinoma of anal canal

    International Nuclear Information System (INIS)

    Squamous cell carcinoma of the anal canal is rather rare and amounts to 3.5% of all rectal neoplasms. Though it has a clear-cut clinical picture, 29.5% of patients admitted for specialized treatment suffer from stage 4 due to inadequate diagnosis. Surgery is the most effective method of management of squamous cell carcinoma of the anal canal. Radiation therapy may be an adjuvant procedure to surgery

  10. Pain associated with root canal treatment

    OpenAIRE

    Segura-Egea, Juan José; Cisneros Cabello, Rafael; Llamas Carreras, José María; Velasco Ortega, Eugenio

    2009-01-01

    Our purpose was to determine the pain experienced by patients during root canal treatment and to correlate with age and gender, pulpal diagnosis, previous periapical status, dental characteristics and length of treatment. One hundred and seventy-six patients (68 men and 108 women), with ages ranged from 6 to 83 years, were randomly recruited. Patients completed a 10-cm visual analogue scale (VAS) that ranked the level of pain experienced during root canal treatment. The mean pain level during...

  11. Mechanics of the Panama Canal slides

    Science.gov (United States)

    Becker, George F.

    1917-01-01

    Dr. Becker visited the Canal Zone in 1913 as a geologist of the United States Geological Survey and since that time has given the problem the benefit of his study. His appointment as a member of the committee of the National Academy of Sciences has made it appropriate for his conclusions, based upon his personal observations and already reported in part to the Canal Commission, to be stated for the benefit of his associates and other American scientists and engineers.

  12. Health at the Extremes. Epidemiological and Sanitary Scene in Tierra del Fuego, 1890-1930

    OpenAIRE

    Romina Casali

    2014-01-01

    Objective: To characterize the epidemiological and sanitary conditions of the city of Ushuaia (National Territory of Tierra del Fuego) at a key time in its history- a time in which interethnic contact and the consolidation of the Argentine nation-state were intensified as two parallel and related processes. Materials and methods: All death certificates available for the period 1890-1930 were analyzed, as well as relevant government documents and secondary sources in order to ob¬tain the healt...

  13. Ecohydrological features of some contrasting mires in Tierra del Fuego, Argentina

    OpenAIRE

    Grootjans, A.; Iturraspe, R.; A. Lanting; Fritz, C.; Joosten, H.

    2010-01-01

    In November 2005, Tierra del Fuego (Argentina) hosted the biennial conference and field excursion of the International Mire Conservation Group (IMCG). The group considered the vegetation, hydrology, peat stratigraphy and possible management options for about 20 mires which were visited during a seven-day excursion. We report here some field observations and measurements of electrical conductivity (EC25) in five mires which have been selected to encompass the most important ecohydrological fea...

  14. Late Holocene climatic changes in Tierra del Fuego based on multiproxy analyses of peat deposits

    OpenAIRE

    Mauquoy, D.; Blaauw, Maarten; van Geel, B; Borromei, A.; M. Quattrocchio; Chambers, F.M.; Possnert, G.

    2004-01-01

    A ca. 1400-yr record from a raised bog in Isla Grande, Tierra del Fuego, Argentina, registers climate fluctuations, including a Medieval Warm Period, although evidence for the 'Little Ice Age' is less clear. Changes in temperature and/or precipitation were inferred from plant macrofossils, pollen, fungal spores, testate amebae, and peat humification. The chronology was established using a C-14 wiggle-matching technique that provides improved age control for at least part of the record compare...

  15. Ethnoarchaeological research in Tierra del Fuego (1986-2006): thoughts for european prehistoric archaeology

    OpenAIRE

    Vila, Assumpció; Mameli, Laura; Terradas, Xavier; Estevez, Jordi; Moreno, Federica; Verdún, Ester; Zurro, Debora; Clemente, Ignacio; Piqué, Raquel; Briz, Ivan; Barcelo, Joan Antón

    2007-01-01

    For 20 years there has been research in Tierra del Fuego in order to contrast ethnographically the archaeological record of hunter-gatherer societies. The objective was to build a specific methodology for an archaeological approach to these societies, that could be applied to various contexts. In this paper we present the projects and the main conclusions emphasizing two fundamental aspects: the technical- methodological one of information recovering and treatment, and the reconstruction of t...

  16. La revelación del fin del mundo: Tierra del Fuego

    OpenAIRE

    Giucci, Guillermo

    2009-01-01

    Se propone una reflexión sobre la relación entre movilidad, conocimiento y transformación. Examino en particular la importancia del Estrecho de Magallanes en el siglo XVI, capítulo inicial del largo y tormentoso proceso de revelación de la Tierra del Fuego, región hoy conocida como el "Fin del Mundo".

  17. Do crustal deformations observed by GPS in Tierra del Fuego (Argentina) reflect glacial-isostatic adjustment?

    OpenAIRE

    Mendoza, L.; A. Richter; Hormaechea, J. L.; Perdomo, R.; Cogliano, D.; R. Dietrich; Fritsche, M.

    2010-01-01

    Vertical site velocities determined by geodetic GPS observations in the Lago Fagnano area, Tierra del Fuego main island, are interpreted with respect to their potential relation with the glacial-isostatic crustal response to ice mass changes. The spatial pattern of the uplift rates, in combination with the horizontal crustal deformation pattern, point towards a fault-tectonic rather than glacial-isostatic origin of the determined vertical crustal deformations. This implies rather small GIA ef...

  18. Morphodynamics of a gravel-dominated macrotidal estuary: Rio Grande, Tierra del Fuego

    OpenAIRE

    Federico I. Isla; Gustavo G. Bujalesky

    2004-01-01

    Rio Grande city (Tierra del Fuego) is located on two attached beach systems, one of Upper Pleistocene (Sangamonian) and the other of Holocene age. Both gravel spits grew from north to south modifying the inlet of the Rio Grande estuary. The present estuary is constrained by the modern and recurved spit Popper Spit. The main characteristic of this macrotidal estuary is that both margins and the bottom are mainly composed of rounded gravel. Expansion of the city is limited by oceanic and estuar...

  19. Real Cédula de tierras de 1780 (2 de Agosto

    Directory of Open Access Journals (Sweden)

    Historia Social y de la Cultura Anuario Colombiano de

    2012-06-01

    Full Text Available Tomado del archivo Histórico Nacional (Bogotá. Tierras de Antioquia, T.X,folios 1 r.-21 v. En la transcripción del documento se introdujeron algunas modificaciones en la ortografía y en la puntuación con el fin de hacer  ágil la utilización del texto.

  20. Disinfection of Contaminated Canals by Different Laser Wavelengths, while Performing Root Canal Therapy.

    Science.gov (United States)

    Asnaashari, Mohammad; Safavi, Nassimeh

    2013-01-01

    Removal of smear layer and disinfection of canals are important objectives of teeth root canal cleaning. In order to achieve this purpose, rinsing substances, intra canal drugs as well as ultrasound are used. Today, use of laser to remove smear layer and to disinfect root canals has increasingly attracted the attentions. Till now different lasers such as CO2, Nd:YAG, Er:YAG, Er,Cr:YSGG have been used for debris and smear removal from the canals. Numerous studies have shown that Er:YAG is the most appropriate laser for intra canal debris and smear removal. In addition different laser wavelengths have been used directly or as an adjunctive to disinfect canals. Laser light can penetrate areas of canals where irrigating and disinfecting solutions cannot reach, like secondary canals and deep dentinal tubules and also can eliminate microorganisms. Different studies have confirmed the penetration of Nd:YAG laser in deep dentin and reduction of microorganisms penetration. But studies on comparison of antibacterial effects of Nd:YAG laser with sodium hypochlorite showed effectiveness of both, with a better effect for sodium hypochlorite. Studies performed in relation with anti-microbial effects of Diode laser with various parameters show that this laser can be effective in reducing intra canal bacterial count and penetration in the depth of 500 microns in dentin. In studies performed on Diode laser in combination with canal irrigating solutions such as sodium hypochlorite and oxygenated water better results were obtained. Although studies on disinfection by the Erbium laser family show that use of this laser alone can be effective in disinfecting canals, studies evaluating the disinfecting effects of this laser and different concentrations of sodium hypochlorite show that the latter alone is more effective in disinfecting canals. And better results were obtained when Erbium laser was used in combination with sodium hypochlorite irrigating solution in canals. Results of the

  1. Las Tierras Indígenas en la Ley 19.253

    Directory of Open Access Journals (Sweden)

    Jaime López Allendes

    Full Text Available Desde el año 1993 rige en Chile una ley que reconoce a las étnias indígenas y señala que la tierra es para estas el fundamento principal de sus existencia y de su cultura. Tal declaración del legislador chileno es el basamento donde se levanta un régimen jurídico especial. Si bien con anterioridad se habían dictado varias leyes que regían las tierras indígenas, aquellas tuvieron por objeto, primero la radicación de los indígenas en comunidades, y luego la división para el ingreso de tales inmuebles al régimen común de propiedad prinvada, y más tarde al mercado. La mayor innovación de la ley en comento se refiere a que reconoce el valor de la tierra como hábitat cultural, y no como una nueva mercancía.

  2. Enfermedades infecciosas probablemente dispersadas por los europeos durante el contacto indirecto en Tierra del Fuego

    Directory of Open Access Journals (Sweden)

    Fugassa, Martín H.

    2003-01-01

    Full Text Available Para la colonización de Norteamérica, ciertos autores sugieren que enfermedades infecciosas actuaron de modo discreto durante un período inicial llamado de Contacto Indirecto. Ello implicaría que los registros históricos con que contamos describan sociedades transformadas. Para Tierra del Fuego, Borrero establece la incertidumbre sobre el tamaño de las poblaciones previas a los primeros relatos de Gusinde y otros. Pretendemos brindar un marco probabilístico sobre las enfermedades infecciosas dispersadas en Tierra del Fuego durante el Contacto Indirecto. Se realizó una evaluación del riesgo de epidemias dentro de las poblaciones nativas (1520-1834. Se consideró el riesgo de contaminación por microorganismos patógenos, según los diversos medios de transporte. Sobre la base de toda la información antes mencionada y de las condiciones ambientales de Tierra del Fuego, construimos un listado de enfermedades infecciosas que probablemente fueron introducidas o aumentadas en frecuencia, dentro del archipiélago durante el período analizado. Este trabajo es parte de un proyecto orientado a analizar la dispersión de las enfermedades en Patagonia Austral

  3. Mitochondrial DNA diversity of feral pigs from Karukinka Natural Park, Tierra del Fuego Island, Chile.

    Science.gov (United States)

    Aravena, P; Skewes, O; Gouin, N

    2015-01-01

    Control or eradication of exotic species is one of the greatest challenges facing biodiversity and ecosystem conservation. Domestic pigs (Sus scrofa domestica) were released and became feral in the southern region of Chilean Tierra del Fuego Island in the 1900s. Currently, they inhabit part of Karukinka Natural Park, an area of global conservation concern. To gain insight into the control of this invasive species, we analyzed genetic variation in the mitochondrial DNA control region to determine the origin and population subdivision of feral pigs in Tierra del Fuego. Sequences from a sample of 42 feral pigs, 10 domestic pigs from local farms, and references from other countries and commercial breeds revealed 2 highly differentiated populations, 1 in the western and the other in the eastern area of the park, each harboring a different haplotype, suggesting no connectivity between populations. Comparison of these haplotypes with reference sequences from other countries and commercial breeds indicated that feral pigs from Chilean Tierra del Fuego are of European origin, very likely from 2 separate introduction events. The haplotype found in the western feral population was also identified in domestic pigs from a farm. This raises concerns regarding the possible connectivity between stocks from local farms and the wild population. Based on these results, we recommend the development of strategies for controlling the population of this invasive species in Karukinka Natural Park. PMID:25966196

  4. Tierras, mujeres y niñez. Familia y conflicto armado

    Directory of Open Access Journals (Sweden)

    Sandra Zorio

    2015-12-01

    Full Text Available Este artículo pretende realizar un análisis socio-jurídico sobre la situación de las mujeres, los niños, niñas y adolescentes y su derecho a la tierra, específicamente, en la aplicación de la Ley de Víctimas y Restitución de Tierras. Se pretende demostrar que a pesar de existir un conjunto de normativas amplias y garantistas en favor de estas poblaciones, las instituciones del Estado encargadas de los temas de tierras no logran recoger en sus procedimientos de política pública la realidad sociológica de las familias desplazadas, y por consiguiente, las mujeres, los niños, niñas y adolescentes quedan excluidos de los mecanismos de acceso al goce efectivo de sus derechos. Todo esto, porque en el Estado habita una noción de familia anacrónica y poco coincidente con la realidad campesina, modelo que supone a la familia como un grupo jerárquico en el que el hombre es el líder y las mujeres y sus hijos e hijas, una especie de auxiliares.

  5. External auditory canal carcinoma treatment

    International Nuclear Information System (INIS)

    External auditory canal (EAC) carcinomas are relatively rare conditions lack on established treatment strategy. We analyzed a treatment modalities and outcome in 32 cases of EAC squamous cell carcinoma treated between 1980 and 2008. Subjects-17 men and 15 women ranging from 33 to 92 years old (average: 66) were divided by Arriaga's tumor staging into 12 T1, 5 T2, 6 T3, and 9 T4. Survival was calculated by the Kaplan-Meier method. Disease-specific 5-year survival was 100% for T1, T2, 44% for T3, and 33% for T4. In contrast to 100% 5-year survival for T1+T2 cancer, the 5-year survival for T3+T4 cancer was 37% with high recurrence due to positive surgical margins. The first 22 years of the 29 years surveyed, we performed surgery mainly, and irradiation or chemotherapy was selected for early disease or cases with positive surgical margins as postoperative therapy. During the 22-years, 5-year survival with T3+T4 cancer was 20%. After we started superselective intra-arterial (IA) rapid infusion chemotherapy combined with radiotherapy in 2003, we achieved negative surgical margins for advanced disease, and 5-year survival for T3+T4 cancer rise to 80%. (author)

  6. Análisis tafonómico en La Arcillosa 2 (Tierra del Fuego, Argentina Taphonomic analysis of La Arcillosa 2 site, Tierra del Fuego, Argentina

    Directory of Open Access Journals (Sweden)

    Fernando C. Santiago

    2007-12-01

    Full Text Available En este trabajo se presenta el análisis tafonómico de los restos arqueofaunísticos y bioarqueológicos recuperados en el sitio La Arcillosa 2 (Tierra del Fuego. El mismo es un sitio multicomponente con fechados radiocarbónicos del Holoceno medio. Se discuten las características de estos dos conjuntos de huesos en particular y se comparan los resultados con datos tafonómicos generados en otros sitios arqueológicos de la isla. La evaluación del efecto de los factores de formación del registro es fundamental para una correcta interpretación de las actividades llevadas a cabo por los cazadores-recolectores en el sitio.In this paper, the tafonomic analysis of the archaeofaunal and bioarchaeological remains recovered from the La Arcillosa 2 site, Tierra del Fuego, is reported. This is a multicomponent site, radiocarbon dated to the middle Holocene. The characteristics of these two bone assemblages are discussed and compared with taphonomic data generated at other archaeological sites on the island. An evaluation of the effect of the record's formation processes is fundamental for an accurate interpretation of the activities carried out by the hunter-gatherers at the site.

  7. The fluid mechanics of root canal irrigation

    International Nuclear Information System (INIS)

    Root canal treatment is a common dental operation aimed at removing the contents of the geometrically complex canal chambers within teeth; its purpose is to remove diseased or infected tissue. The complex chamber is first enlarged and shaped by instruments to a size sufficient to deliver antibacterial fluids. These irrigants help to dissolve dying tissue, disinfect the canal walls and space and flush out debris. The effectiveness of the procedure is limited by access to the canal terminus. Endodontic research is focused on finding the instruments and clinical procedures that might improve success rates by more effectively reaching the apical anatomy. The individual factors affecting treatment outcome have not been unequivocally deciphered, partly because of the difficulty in isolating them and in making the link between simplified, general experimental models and the complex biological objects that are teeth. Explicitly considering the physical processes within the root canal can contribute to the resolution of these problems. The central problem is one of fluid motion in a confined geometry, which makes the dispersion and mixing of irrigant more difficult because of the absence of turbulence over much of the canal volume. The effects of treatments can be understood through the use of scale models, mathematical modelling and numerical computations. A particular concern in treatment is that caustic irrigant may penetrate beyond the root canal, causing chemical damage to the jawbone. In fact, a stagnation plane exists beyond the needle tip, which the irrigant cannot penetrate. The goal is therefore to shift the stagnation plane apically to be coincident with the canal terminus without extending beyond it. Needle design may solve some of the problems but the best design for irrigant penetration conflicts with that for optimal removal of the bacterial biofilm from the canal wall. Both irrigant penetration and biofilm removal may be improved through canal fluid

  8. Quantification of brown dog tick repellents, 2-hexanone and benzaldehyde, and release from tick-resistant beagles, Canis lupus familiaris.

    Science.gov (United States)

    de Oliveira Filho, Jaires Gomes; Sarria, André Lucio Franceschini; Ferreira, Lorena Lopes; Caulfield, John C; Powers, Stephen J; Pickett, John A; de León, Adalberto A Pérez; Birkett, Michael A; Borges, Lígia Miranda Ferreira

    2016-06-01

    We have recently shown that repellency of the tick Rhipicephalus sanguineus sensu lato by the tick resistant dog breed, the beagle, is mediated by volatile organic compounds (VOCs) 2-hexanone and benzaldehyde present in beagle odour. Ectoparasite location of animal hosts is affected by variation in these odour components and their ratios. The aim of this study was to quantify the release rate, and the ratio, of 2-hexanone and benzaldehyde from beagles. The odour of three beagles was collected, for four days, over one week (day 0, day 1, day 4 and day 7). The compounds were identified using coupled high-resolution gas chromatography-mass spectrometry (GC-MS), and authentic standards of compounds were used to generate external calibration curves for quantification. Both compounds were found in all dogs on all days. The amount of benzaldehyde was always higher than that of 2-hexanone and so their ratio varied from unity, on average (over time) being 3.128±0.365, 1.902±0.390, 1.670±0.671ngmL(-1) for beagle 1, 2 and 3, respectively. There was no significant (p<0.05, F-test) effect of time. The overall mean was 2.233±0.387ngmL(-1). These results further previous findings by documenting the presence of 2-hexanone and benzaldehyde in beagle odour samples covering a 7-day period. This knowledge enables development of repellents to protect dogs from R. sanguineus s. l. infestation. PMID:27085013

  9. Treatment of extremely severe acute hemopoietic radiation sickness beagles with RhG-CSF and RhIL-11

    International Nuclear Information System (INIS)

    Objective: To evaluate the effects of treatment combined recombinant human G-CSF (rhG-CSF) and recombinant human interleukin-11 (rhIL-11) on severe acute hemopoietic radiation sickness (ARS) beagles. Methods: Beagles were irradiated with 4.5 Gy 60Co γ-ray to establish ARS models, and animals were divided into the irradiated control group and the supportive care and combined cytokines treatment cohort. After irradiation the irradiated control beagles was given no treatment, the supportive care beagles received purely symptomatic treatment including blood transfusion and anti-infection while the combined cytokines treatment beagles received rhG-CSF and rhIL-11 subcutaneously for three weeks besides symptomatic treatment.Results After irradiation, all kinds of cells' population declined sharply, but rebounded to normal basically in the combined cytokines treatment rate in the cohort. The mean blood transfusion volume of cytokines in the cohort and the period of blood transfusion all were less than those in the supportive care cohort (P<0.01). The period of administrated antibiotic of cytokines in the cohort was shorter than that in the supportive care cohort (P<0.05). In the observe period of 45 d, survival rate in the irradiated controls cohort was 0%, in the supportive care cohort was 80%, and in the combined cytokines treatment cohort was 100%(P<0.01). Conclusion: Administration of rhG-CSF and rhIL-11 early after irradiation and continued daily, in combined with supportive care in severe acute hemopoietic radiation sickness beagles can improve hematopoietic function restoration, stimulate blood cells to restore to the normal level quickly, significantly decrease the reguired volume of blood transfusion, shorten the period of anti-infection and increase survival of irradiated canines. (authors)

  10. Study of single dose toxic test of Sweet Bee Venom in Beagle Dogs

    Directory of Open Access Journals (Sweden)

    Hye-Chul, Yoon

    2010-12-01

    Full Text Available Objectives : This study was performed to analyse single dose toxicity of Sweet Bee Venom(Sweet BV extracted from the bee venom in Beagle dogs. Methods : All experiments were conducted under the regulations of Good Laboratory Practice (GLP at Biotoxtech Company, a non-clinical study authorized institution. Male and female Beagle dogs of 5-6 months old were chosen for the pilot study of single dose toxicity of Sweet BV which was administered at the level of 9.0 ㎎/㎏ body weight which is 1300 times higher than the clinical application dosage as the high dosage, followed by 3.0 and 1.0 ㎎/㎏ as midium and low dosage, respectively. Equal amount of excipient(normal saline to the Sweet BV experiment groups was administered as the control group. Results : 1. No mortality was witnessed in all of the experiment groups. 2. Hyperemia and movement disorder were observed around the area of administration in all the experiment groups, and higher occurrence in the higher dosage treatment. 3. For weight measurement, Neither male nor female groups showed significant changes. 4. To verify abnormalities of organs and tissues, thigh muscle which treated with Sweet BV, brain, liver, lung, kidney, and spinal cords were removed and histologocal observation using H-E staining was conducted. In the histologocal observation of thigh muscle, cell infiltration, inflammation, degeneration, necrosis of muscle fiber, and fibrosis were found in both thigh tissue. And the changes depend on the dose of Sweet BV. But the other organs did not showed in any abnormality. 5. The maximum dose of Sweet BV in Beagle dogs were over 9 ㎎/㎏ in this study. Conclusions : The above findings of this study suggest that Sweet BV is a relatively safe treatment medium. Further studies on the toxicity of Sweet BV should be conducted to yield more concrete evidences.

  11. Localization of Helicobacter spp. in the fundic mucosa of laboratory Beagle dogs: an ultrastructural study

    Directory of Open Access Journals (Sweden)

    Lanzoni Anna

    2011-03-01

    Full Text Available Abstract In dogs Helicobacter spp. are found in all gastric regions usually localized in the surface mucus, gastric glands and parietal cells. The aim of this study was to detail the distribution of Helicobacter spp. in the fundic mucosa of asymptomatic Beagle dogs and their intracellular localization within parietal cells, in order to evaluate species-specific pathogenetic effects on gastric cells. The presence of Helicobacter spp. was investigated by immunohistochemistry, TEM, and PCR in the fundic mucosa of six Beagle dogs. Helicobacter spp. were found in all dogs examined, and H. bizzozeronii and H. felis were identified by PCR and confirmed by TEM. In the lumen of the fundic glands, co-localization was common. H. bizzozeronii was present in larger numbers than H. felis in both intraluminal and intraparietal localization. The amounts of H. bizzozeronii were similar in superficial and basal portions of the glands. H. felis was predominantly localized in the superficial portions of gastric glands but almost absent from the base. Within parietal cells, most Helicobacter organisms were intracanalicular, but intact and degenerate Helicobacter organisms were also visualized free in the cytoplasm or in secondary lysosomes. No specific degenerative lesions were found in infected parietal cells. Helicobacter organisms were also observed within macrophages in the lamina propria. In conclusion, there is a differential distribution of H. bizzozeronii and H. felis in the fundic mucosa of Beagle dogs, and their intracellular localization in parietal cells and macrophages suggests novel pathogenic scenarios for the development of immune response and maintenance of chronic gastritis in dogs.

  12. Minipig and beagle animal model genomes aid species selection in pharmaceutical discovery and development

    Energy Technology Data Exchange (ETDEWEB)

    Vamathevan, Jessica J., E-mail: jessica.j.vamathevan@gsk.com [Computational Biology, Quantitative Sciences, GlaxoSmithKline, Stevenage (United Kingdom); Hall, Matthew D.; Hasan, Samiul; Woollard, Peter M. [Computational Biology, Quantitative Sciences, GlaxoSmithKline, Stevenage (United Kingdom); Xu, Meng; Yang, Yulan; Li, Xin; Wang, Xiaoli [BGI-Shenzen, Shenzhen (China); Kenny, Steve [Safety Assessment, PTS, GlaxoSmithKline, Ware (United Kingdom); Brown, James R. [Computational Biology, Quantitative Sciences, GlaxoSmithKline, Collegeville, PA (United States); Huxley-Jones, Julie [UK Platform Technology Sciences (PTS) Operations and Planning, PTS, GlaxoSmithKline, Stevenage (United Kingdom); Lyon, Jon; Haselden, John [Safety Assessment, PTS, GlaxoSmithKline, Ware (United Kingdom); Min, Jiumeng [BGI-Shenzen, Shenzhen (China); Sanseau, Philippe [Computational Biology, Quantitative Sciences, GlaxoSmithKline, Stevenage (United Kingdom)

    2013-07-15

    Improving drug attrition remains a challenge in pharmaceutical discovery and development. A major cause of early attrition is the demonstration of safety signals which can negate any therapeutic index previously established. Safety attrition needs to be put in context of clinical translation (i.e. human relevance) and is negatively impacted by differences between animal models and human. In order to minimize such an impact, an earlier assessment of pharmacological target homology across animal model species will enhance understanding of the context of animal safety signals and aid species selection during later regulatory toxicology studies. Here we sequenced the genomes of the Sus scrofa Göttingen minipig and the Canis familiaris beagle, two widely used animal species in regulatory safety studies. Comparative analyses of these new genomes with other key model organisms, namely mouse, rat, cynomolgus macaque, rhesus macaque, two related breeds (S. scrofa Duroc and C. familiaris boxer) and human reveal considerable variation in gene content. Key genes in toxicology and metabolism studies, such as the UGT2 family, CYP2D6, and SLCO1A2, displayed unique duplication patterns. Comparisons of 317 known human drug targets revealed surprising variation such as species-specific positive selection, duplication and higher occurrences of pseudogenized targets in beagle (41 genes) relative to minipig (19 genes). These data will facilitate the more effective use of animals in biomedical research. - Highlights: • Genomes of the minipig and beagle dog, two species used in pharmaceutical studies. • First systematic comparative genome analysis of human and six experimental animals. • Key drug toxicology genes display unique duplication patterns across species. • Comparison of 317 drug targets show species-specific evolutionary patterns.

  13. [Pharmacokinetic interaction of pioglitazone hydrochloride and atorvastatin calcium in Beagle dogs].

    Science.gov (United States)

    Chen, He-Li; Zhang, Wen-Ping; Yang, Fu-Ying; Wang, Xin-Yu; Yang, Wen-Cheng; Dang, Hong-Wan

    2013-05-01

    The object of this study is to investigate the pharmacokinetic interaction of pioglitazone hydrochloride and atorvastatin calcium in healthy adult Beagle dogs following single and multiple oral dose administration. A randomized, cross-over study was conducted with nine healthy adult Beagle dogs assigned to three groups. Each group was arranged to take atorvastatin calcium (A), pioglitazone hydrochloride (B), atorvastatin calcium and pioglitazone hydrochloride (C) orally in the first period, to take B, C, A in the second period, and to take C, A, B in the third period for 6 days respectively. The blood samples were collected at the first and the sixth day after the administration, plasma drug concentrations were determined by LC-MS/MS, a one-week wash-out period was needed between each period. The pharmacokinetic parameters of drug combination group and the drug alone group were calculated by statistical moment method, calculation of C(max) and AUC(0-t) was done by using 90% confidence interval method of the bioequivalence and bioavailability degree module DAS 3.2.1 software statistics. Compared with the separate administration, the main pharmacokinetic parameters (C(max) and AUC(0-t)) of joint use of pioglitazone hydrochloride and atorvastatin calcium within 90% confidence intervals for bioequivalence statistics were unqualified, the mean t(max) with standard deviation used paired Wilcoxon test resulted P > 0.05. There was no significant difference within t1/2, CL(int), MRT, V/F. Pioglitazone hydrochloride and atorvastatin calcium had pharmacokinetic interaction in healthy adult Beagle dogs. PMID:23888699

  14. Minipig and beagle animal model genomes aid species selection in pharmaceutical discovery and development

    International Nuclear Information System (INIS)

    Improving drug attrition remains a challenge in pharmaceutical discovery and development. A major cause of early attrition is the demonstration of safety signals which can negate any therapeutic index previously established. Safety attrition needs to be put in context of clinical translation (i.e. human relevance) and is negatively impacted by differences between animal models and human. In order to minimize such an impact, an earlier assessment of pharmacological target homology across animal model species will enhance understanding of the context of animal safety signals and aid species selection during later regulatory toxicology studies. Here we sequenced the genomes of the Sus scrofa Göttingen minipig and the Canis familiaris beagle, two widely used animal species in regulatory safety studies. Comparative analyses of these new genomes with other key model organisms, namely mouse, rat, cynomolgus macaque, rhesus macaque, two related breeds (S. scrofa Duroc and C. familiaris boxer) and human reveal considerable variation in gene content. Key genes in toxicology and metabolism studies, such as the UGT2 family, CYP2D6, and SLCO1A2, displayed unique duplication patterns. Comparisons of 317 known human drug targets revealed surprising variation such as species-specific positive selection, duplication and higher occurrences of pseudogenized targets in beagle (41 genes) relative to minipig (19 genes). These data will facilitate the more effective use of animals in biomedical research. - Highlights: • Genomes of the minipig and beagle dog, two species used in pharmaceutical studies. • First systematic comparative genome analysis of human and six experimental animals. • Key drug toxicology genes display unique duplication patterns across species. • Comparison of 317 drug targets show species-specific evolutionary patterns

  15. BEAGLE: An Application Programming Interface and High-Performance Computing Library for Statistical Phylogenetics

    Science.gov (United States)

    Ayres, Daniel L.; Darling, Aaron; Zwickl, Derrick J.; Beerli, Peter; Holder, Mark T.; Lewis, Paul O.; Huelsenbeck, John P.; Ronquist, Fredrik; Swofford, David L.; Cummings, Michael P.; Rambaut, Andrew; Suchard, Marc A.

    2012-01-01

    Phylogenetic inference is fundamental to our understanding of most aspects of the origin and evolution of life, and in recent years, there has been a concentration of interest in statistical approaches such as Bayesian inference and maximum likelihood estimation. Yet, for large data sets and realistic or interesting models of evolution, these approaches remain computationally demanding. High-throughput sequencing can yield data for thousands of taxa, but scaling to such problems using serial computing often necessitates the use of nonstatistical or approximate approaches. The recent emergence of graphics processing units (GPUs) provides an opportunity to leverage their excellent floating-point computational performance to accelerate statistical phylogenetic inference. A specialized library for phylogenetic calculation would allow existing software packages to make more effective use of available computer hardware, including GPUs. Adoption of a common library would also make it easier for other emerging computing architectures, such as field programmable gate arrays, to be used in the future. We present BEAGLE, an application programming interface (API) and library for high-performance statistical phylogenetic inference. The API provides a uniform interface for performing phylogenetic likelihood calculations on a variety of compute hardware platforms. The library includes a set of efficient implementations and can currently exploit hardware including GPUs using NVIDIA CUDA, central processing units (CPUs) with Streaming SIMD Extensions and related processor supplementary instruction sets, and multicore CPUs via OpenMP. To demonstrate the advantages of a common API, we have incorporated the library into several popular phylogenetic software packages. The BEAGLE library is free open source software licensed under the Lesser GPL and available from http://beagle-lib.googlecode.com. An example client program is available as public domain software. PMID:21963610

  16. Posterior semicircular canal dehiscence: a morphologic cause of vertigo similar to superior semicircular canal dehiscence

    International Nuclear Information System (INIS)

    Heading Abstract.The aim of this study was to assess imaging findings of posterior semicircular dehiscence on computed tomography and to evaluate incidence of posterior and superior semicircular canal dehiscence in patients presenting with vertigo, sensorineuronal hearing loss or in a control group without symptoms related to the inner ear. Computed tomography was performed in 507 patients presenting either with vertigo (n=128; 23 of these patients suffered also from sensorineuronal hearing loss), other symptoms related to the inner ear, such as hearing loss or tinnitus (n=183) or symptoms unrelated to the labyrinth (n=196). All images were reviewed for presence of dehiscence of the bone, overlying the semicircular canals. Twenty-nine patients had superior semicircular canal dehiscence. Of these patients, 83% presented with vertigo, 10% with hearing loss or tinnitus and the remaining 7% with symptoms unrelated to the inner ear. In 23 patients dehiscence of the posterior semicircular canal was encountered. Of these patients, 86% presented with vertigo, 9% with hearing loss or tinnitus and 5% with symptoms unrelated to the inner ear. Defects of the bony overly are found at the posterior semicircular canal, in addition to the recently introduced superior canal dehiscence syndrome. Significant prevalence of vertigo in these patients suggests that posterior semicircular canal dehiscence can cause vertigo, similar to superior semicircular canal dehiscence. (orig.)

  17. Posterior semicircular canal dehiscence: a morphologic cause of vertigo similar to superior semicircular canal dehiscence

    Energy Technology Data Exchange (ETDEWEB)

    Krombach, G.A.; Schmitz-Rode, T.; Haage, P.; Guenther, R.W. [Department of Diagnostic Radiology, University of Technology, Pauwelstrasse 30, 52057, Aachen (Germany); DiMartino, E. [Department of Otorhinolaryngology, University of Technology, Pauwelstrasse 30, 52057, Aachen (Germany); Prescher, A. [Department of Anatomy, University of Technology, Pauwelstrasse 30, 52057, Aachen (Germany); Kinzel, S. [Department of Experimental Veterinarian Medicine, University of Technology, Pauwelstrasse 30, 52057, Aachen (Germany)

    2003-06-01

    Heading Abstract.The aim of this study was to assess imaging findings of posterior semicircular dehiscence on computed tomography and to evaluate incidence of posterior and superior semicircular canal dehiscence in patients presenting with vertigo, sensorineuronal hearing loss or in a control group without symptoms related to the inner ear. Computed tomography was performed in 507 patients presenting either with vertigo (n=128; 23 of these patients suffered also from sensorineuronal hearing loss), other symptoms related to the inner ear, such as hearing loss or tinnitus (n=183) or symptoms unrelated to the labyrinth (n=196). All images were reviewed for presence of dehiscence of the bone, overlying the semicircular canals. Twenty-nine patients had superior semicircular canal dehiscence. Of these patients, 83% presented with vertigo, 10% with hearing loss or tinnitus and the remaining 7% with symptoms unrelated to the inner ear. In 23 patients dehiscence of the posterior semicircular canal was encountered. Of these patients, 86% presented with vertigo, 9% with hearing loss or tinnitus and 5% with symptoms unrelated to the inner ear. Defects of the bony overly are found at the posterior semicircular canal, in addition to the recently introduced superior canal dehiscence syndrome. Significant prevalence of vertigo in these patients suggests that posterior semicircular canal dehiscence can cause vertigo, similar to superior semicircular canal dehiscence. (orig.)

  18. A comparison of Ca-DTPA and Zn-DTPA for chelating 241Am in beagles

    International Nuclear Information System (INIS)

    Results of a comparative study of the efficiency of removing body burdens of 241Am in beagles subjected to chelation therapy with either Ca-DTPA or Zn-DTPA are given. It is shown that on an equimolar basis the efficacy of the calcium salt is not greater than the zinc salt for treatments begun 2 weeks after radionuclide injection. The authors suggest that due to the much greater toxicity which has been shown for Ca-DTPA, it appears that Zn-DTPA should replace Ca-DTPA as treatment of choice in human cases. (U.K.)

  19. Liver tumors in Beagle dogs exposed by inhalation to 144CeCl3

    International Nuclear Information System (INIS)

    Primary malignant hepatic neoplasms developed in 9 of 55 Beagle dogs (16 percent) exposed to 144CeCl3 in CsCl aerosol (seven primary hepatic hemangiosarcomas, one hepatocellular carcinoma and one intrahepatic bile duct carcinoma). Cerium-144 was rapidly translocated from the lung to the liver and skeleton; the liver received the highest cumulative beta dose. The latent periods of hepatic hemangiosarcomas appeared to be dose-related; death from hepatic hemangiosarcoma occurred earlier in dogs which received higher beta doses

  20. Accuracy of sonographic diagnosis of pneumoperitoneum using the enhanced peritoneal stripe sign in beagle dogs

    OpenAIRE

    Kim, Song Yeon; Park, Ki Tae; Yeon, Seong Chan; Lee, Hee Chun

    2014-01-01

    The objective of this study was to evaluate the feasibility and accuracy of estimating the smallest amount of abdominal free gas detectible in a large population of beagles by ultrasonography. Healthy dogs were randomly divided into three groups: group A that received 0.1 mL of air injected into the peritoneal cavity, group B that received 0.2 mL of air injected into the peritoneal cavity, and group C that received 0.5 mL of intraperitoneal air. Randomly, some dogs in each group did not recei...

  1. Repeated inhalation exposure of Beagle dogs to aerosols of 239PuO2. XII

    International Nuclear Information System (INIS)

    Beagle dogs were exposed once or semi-annually for 10 yr by inhalation to aerosols of 239PuO2 to study the relative doses and effects of these two types of exposures. All exposures have been completed. Dogs exposed at high levels died predominantly of radiation pneumonitis and pulmonary fibrosis. Dogs exposed at lower levels, either once or repeatedly, are dying of a variety of causes including lung cancer. Dogs have survived up to 11 yr after their first exposure. Preliminary results suggest that single and repeated exposures cause similar health effects for equal accumulated radiation doses. (author)

  2. Toxicity of 90Sr inhaled in a relatively insoluble form by Beagle dogs. XVII

    International Nuclear Information System (INIS)

    This study was initiated to determine health effects resulting from inhalation of 90Sr in relatively insoluble form. Beagle dogs were briefly exposed by inhalation to produce lung burdens of 90Sr that ranged from 0.12 to 96 μCi (4.4-3500 kBq)/kg body weight. Exposures to the higher concentrations of 90Sr caused radiation pneumonitis and pulmonary fibrosis, typically resulting in death 90Sr-exposed dogs were euthanized during the past year. One remaining exposed dog and one control dog are both 14 yr old and are being maintained for lifetime observation. (author)

  3. Deposition of inhaled LMFBR-fuel-sodium aerosols in beagle dogs

    International Nuclear Information System (INIS)

    Initial alveolar deposition of LMFBR-fuel aerosols in beagle dogs amounted to 30% of the inhaled activity, but only 5% of the total inhaled activity was deposited in dogs exposed to sodium-fuel aerosols. Aerosol deposition in the gastrointestinal tract amounted to 4% of the initial body burden of fuel-aerosol exposed dogs and 24% of the burden of animals receiving sodium-fuel aerosols. Preliminary analytical data for the dog exposures appear to agree with rodent data for deposition and distribution patterns of aerosols of similar sodium: fuel ratios

  4. Beagle: an appropriate experimental animal for extrapolating the organ distribution pattern of Th in humans

    International Nuclear Information System (INIS)

    The concentrations and the organ distribution patterns of 228Th, 230Th and 232Th in two 9-y-old dogs of our beagle colony were determined. The dogs were exposed only to background environmental levels of Th isotopes through ingestion (food and water) and inhalation as are humans. The organ distribution patterns of the isotopes in the beagles were compared to the organ distribution patterns in humans to determine if it is appropriate to extrapolate the beagle organ burden data to humans. Among soft tissues, only the lungs, lymph nodes, kidney and liver, and skeleton contained measurable amounts of Th isotopes. The organ distribution pattern of Th isotopes in humans and dog are similar, the majority of Th being in the skeleton of both species. The average skeletal concentrations of 228Th in dogs were 30 to 40 times higher than the average skeletal concentrations of the parent 232Th, whereas the concentration of 228Th in human skeleton was only four to five times higher than 232Th. This suggests that dogs have a higher intake of 228Ra through food than humans. There is a similar trend in the accumulations of 232Th, 230Th and 228Th in the lungs of dog and humans. The percentages of 232Th, 230Th and 228Th in human lungs are 26, 9.7 and 4.8, respectively, compared to 4.2, 2.6 and 0.48, respectively, in dog lungs. The larger percentages of Th isotopes in human lungs may be due simply to the longer life span of humans. If the burdens of Th isotopes in human lungs are normalized to an exposure time of 9.2 y (mean age of dogs at the time of sacrifice), the percent burden of 232Th, 230Th and 228Th in human lungs are estimated to be 3.6, 1.3 and 0.66, respectively. These results suggest that the beagle may be an appropriate experimental animal for extrapolating the organ distribution pattern of Th in humans

  5. Age incidence and site distribution of mammary dysplasias in young beagle bitches

    Energy Technology Data Exchange (ETDEWEB)

    Warner, M.R.

    1976-07-01

    The age incidence and site distribution of 2,142 mammary dysplasias were documented for 39 beagle bitches 6 months to 4 years of age. Lesion onset was at 2-3 years of age, at which time more than 50 percent of the females had dysplasias. Dysplasias appeared before palpable tumors. Posterior mammae developed more lesions than did anterior mammae. Thus the gradient for early onset of lesions coincided with the gradient for tumor frequency reported previously; a preneoplastic potential is suggested for (some) dysplasias. Problems of defining normal tissue are discussed.

  6. Radiological Review Studies On Ismailia Canal Ecology

    International Nuclear Information System (INIS)

    The present work is a brief review of pr-studies carried out on Ismailia Canal, Egypt, water ecosystem. Ismailia Canal water body is a bicarbonate stream with slight seasonal variations in its water chemical constituents. The canal water pH in all the stream locations are below 8.3 with low suspended matter(SM) content (22-33 mg.l-1). The mineralogical analysis of the canal bottom sediments consist mainly of quartz, smectite and kaolinite minerals. The γ- spectroscopic identification showed traces of naturally occurring radio nuclides (238U, 232Th and 40K). The average activity level of the dry samples ranged from 12 to 89 Bq.Kg-1 for the detected natural radio nuclides. Some parameters affected the sorption behaviour of radio nuclides on suspended matters and bottom sediments; such as solution pH, SM concentration, sediment grain size, carrier concentration and competing ions were studied. The reaction rates were investigated for each radionuclide studied. The distribution of the studied radio nuclides, between the liquid phase and the sediments phase was investigated, for both flowing and static systems. For both flowing and non-flowing (static), the depth penetration of the studied radio nuclides within the bottom sediment layers were found to vary from one radionuclide to the other. The total capacities of bottom sediments and the suspended matter were found to be low. As Ismailia Canal is an important source of water for public domestic uses, irrigation animals and the aquatic species; these situations have led to state that it is not recommended to release any liquid radioactive wastes to this canal. Furthermore, periodical radiometric analysis for the canal water and its components should be carried out.

  7. Radiation-induced external ear canal cholesteatoma-like disease

    International Nuclear Information System (INIS)

    Three cases of cholesteatoma-like disease in the ear canals after radiation therapy for head and neck tumor were reported. Effect of irradiation on bone and soft tissue including skin brings about pathological reaction to the external ear canal as well. Two types of disease resembling cholesteatomas have been recognized: keratosis obturans (KO) and external auditory canal cholesteatoma (EACC). KO appears to be derived from disease of canal skin involved with keratinization, creating a widning of the canal. EACC, on the other hand, seems to develop in the disease of bony canal where a localized absorption of its bone with invasion of squamous epithelium takes place. (author)

  8. El cambio climático global en la Patagonia desde el viaje de Charles Darwin hasta nuestros días The global climatic change in Patagonia and Tierra del Fuego since voyage of Charles Darwin until present times

    Directory of Open Access Journals (Sweden)

    Jorge Rabassa

    2010-08-01

    Full Text Available El viaje del Beagle que trajo a Charles Darwin a América del Sur entre 1832 y 1835 AD y en particular, al territorio argentino, se desarrolló bajo condiciones climáticas muy desfavorables: frías, secas y ventosas, correspondientes a las condiciones predominantes en la última fase de la pequeña edad del hielo, un episodio frío global que caracterizó a los siglos XVII, XVIII y XIX. Esta fase es conocida como mínimo de Dalton, en referencia a la disminución relativa de la frecuencia de las manchas solares, lo cual redunda en una disminución de la radiación solar y como consecuencia, en menores temperaturas medias globales en ese período. Darwin fue perfectamente consciente de dichas condiciones climáticas, que se manifestaban fuertemente en Europa, en particular en los Alpes, y así lo transmite en sus escritos. Desde el viaje de Darwin a la Patagonia, las condiciones climáticas y ambientales cambiaron sustancialmente, especialmente luego de 1850 AD y, finalmente, después de mediados de la década de 1970 AD. Algunas de las más importantes consecuencias del cambio climático global son el aumento de la temperatura media anual o la temperatura estacional, la elevación o disminución de las precipitaciones al nivel regional, el continuo ascenso global del nivel del mar y un incremento significativo de la frecuencia de eventos meteorológicos extremos. El impacto de esos cambios ha sido observado en los glaciares de Patagonia y Tierra del Fuego, por lo menos desde 1978 AD, y particularmente en la última década del siglo XX. Los impactos más notables son la rápida recesión de las márgenes del hielo en los glaciares, el adelgazamiento de la cobertura glacial, la elevación de la línea de nieve regional y la reducción de las áreas andinas bajo condiciones de suelos permanentemente congelados (permafrost, como han demostrado estudios científicos recientes. A la tasa presente de recesión del hielo glacial, la mayoría, si no

  9. Comparative toxicity of strontium-90 and radium-226 in beagle dogs

    International Nuclear Information System (INIS)

    The authors are completing a 30-year study of the biologic effects of 90Sr and 226Ra in the beagle in order to predict the possible long-term hazards to people from chronic exposure to low levels of irradiation. Animals received either radionuclide by several means of administration: (a) continual ingestion of 90Sr, (b) a single intravenous injection of 90Sr, or (c) a series of eight intravenous injections of 226Ra. Although administration of 90Sr and 226Ra ended at 540 days of age, the animals continued to receive chronic, low-level radiation doses from these bone-seeking radionuclides throughout life. This project is the largest single cohort study in beagles of internally deposited radionuclides. It is unique in use of the ingestion route for 90Sr and in exposures that began before birth and continued throughout development to adulthood with uniform labeling of the skeletons with 90Sr. The last of the dogs died in 1986 at age 18.5, but the authors are continuing to investigate the significance of these long-term exposures given at low dose rates with regard to cancer production, physiologic well-being, and shortening of life through the detailed records that were kept and by study of preserved materials. All the data have been successfully accumulated and entered into a main-frame computer data base management system. Current work is exclusively directed at preparing research papers summarizing the results and the associated biostatistical and survival analyses

  10. Comparative toxicity of strontium-90 and radium-226 in beagle dogs

    International Nuclear Information System (INIS)

    The authors are completing a 30-year study of the biological effects of 90Sr and 226Ra in the beagle in order to predict the possible long-term hazards to people from chronic exposure to low levels of irradiation. Animals received either radionuclide by several means of administration: (a) continual ingestion of 90Sr, (b) a single intravenous injection of 90Sr, or (c) a series of eight intravenous injections of 226Ra. Although administration of 90Sr and 226Ra ended at 540 days of age, the animals continued to receive chronic, low-level radiation doses from these bone-seeking radionuclides throughout life. This project is the largest single cohort study in beagles of internally deposited radionuclides. It is unique in use of the ingestion route for 90Sr and in exposures that began before birth and continued throughout development to adulthood with uniform labeling of the skeletons with 90Sr. The last of the dogs died in 1986 at age 18.5 years, but the authors are continuing to investigate the significance of these long-term exposures given at low dose rates with regard to cancer production, physiologic well-being, and shortening of life through the detailed records that were kept and by study of preserved materials. All the data have been successfully accumulated and entered into a main-frame computer data base management system. Current work is exclusively directed at preparing research papers summarizing the results and the associated biostatistical and survival analyses

  11. Lifetime effects of long-term exposures to strontium-90 and radium-226 in beagle dogs

    International Nuclear Information System (INIS)

    Graded doses of injected 226Ra or ingested 90Sr were given to 804 beagles in early life. The median survival times of the various irradiated groups at higher exposures were lower than the control value of 14.7 years. The 226Ra group with the highest total skeletal dose had a median survival of 4.5 years. For 90Sr the highest group had a median survival of 2.2 years. Normal life spans were evident in treatment groups with average skeletal doses of 226Ra or of 2600 rads from 90Sr. The life-shortening effects of 226Ra and 90Sr are related to the tumors produced from the radionuclide exposure. The significant causes of death among the 226Ra-treated beagles were primary bone cancers, mostly osteosarcomas. Among dogs exposed to 90Sr, significant numbers of deaths were from primary bone cancer, myeloproliferative disease, and squamous-cell carcinoma of the gingiva. In general, more of these effects were produced in the groups receiving higher doses and dose rates; at lower doses the effects, when present, appeared later than they did at higher doses. 9 refs., 6 figs., 4 tabs

  12. The removal of inhaled 239Pu from beagle dogs by bronchopulmonary lavage and chelation therapy

    International Nuclear Information System (INIS)

    The efficacy of bronchopulmonary lavage and chelatan therapy for removing 239Pu from beagle dogs after inhalation of 239Pu aerosols having different solubilities has been investigated. The four aerosols used were nebulized from a solution of 239PuCl4 and heat treated at temperatures of 325, 600, 900 and 11500C. Groups of six beagle dogs were exposed to each of the aerosols. Subsequently, three dogs in each group were treated by lavage and intravenous injections of DTPA. The remaining three dogs in each group served as untreated controls. It was found that bronchopulmonary lavage treatment was effective in removing nearly half of the 239Pu activity from the lung regardless of the aerosol production temperature. This early removal of 239Pu activity resulted in a significant reduction in daily dose rate and therefore cumulative α dose to lung. The effectiveness of DTPA treatment depended on aerosol production temperature, and was effective in reducing accumulation of 239Pu in liver and skeleton of the dogs that inhaled aerosols produced at 3250 and 6000C by enhancing urinary excretion of 239Pu. (U.K.)

  13. Framing Space: UK Newspaper Reporting of the Beagle 2 and Cassini-Huygens Space Missions

    Science.gov (United States)

    Jergovic, B.; Miller, S.

    2008-05-01

    Relatively little scholarly work has been done on looking at the portrayal of astronomy and space science in the media. This short article examines the UK press coverage of two space missions: the Beagle 2 mission to Mars and the Cassini-Huygens mission to Saturn and its moon Titan. In both cases, the leading scientists exerted a strong influence on what journalists reported, to the extent that some journalists appeared to be almost "embedded" in the mission. For the most part the coverage is positive in tone and the loss of the Beagle 2 spacecraft does not reflect badly on the (later) Cassini-Huygens coverage. Most journalists only covered the actual mission events and, in the case of Huygens, did not follow up to cover the peer-reviewed scientific articles that appeared later. Off-the-cuff comments made by scientists at the time of the missions were widely reported. There appears to be an appreciation by journalists and (by inference) their readership that this was science in the making, and that allowances should be made if these comments later turned out to be inaccurate.

  14. Effects of dietary protein and ethanol intake on pregnant beagles fed purified diets.

    Science.gov (United States)

    Switzer, B R; Anderson, J J; Pick, J R

    1986-04-01

    Maternal weight gain of beagles was approximately 50% lower when ethanol was given twice daily at a dose of 1.8 g/kg body weight with either control protein (17% energy from protein) or low protein (8.5%) diet as compared to isocalorically sucrose-treated animals. Similarly, pup birth weights were about 27% lower from beagles given ethanol with either diet when compared to those from sucrose-treated bitches. Two weeks after beginning ethanol treatment, pregnant bitches fed either diet had higher hematocrit values and lower plasma concentrations of albumin and calcium as compared to sucrose-treated animals. Low dietary protein treatment, rather than ethanol, lowered maternal concentrations of red blood cell folate during pregnancy. As compared to sucrose-treated bitches, ethanol prevented folate levels in red blood cells from returning to the normal range by the 9th wk of pregnancy in animals fed low dietary protein. These data show that ethanol consumption and low dietary protein intake, independently of each other, significantly depress maternal weight gain, pup birth weight and some nutritionally related parameters of the mother. PMID:3958813

  15. Lymphocytopenia induced in beagle dogs by inhalation of 239PuO2

    International Nuclear Information System (INIS)

    To determine the life-span dose-effect relationships of inhaled plutonium, we gave 124 beagle dogs a single exposure of 239PuO2 2 to 3 years ago at six different levels, i.e., 4, 20, 80, 300, 1100, or 5800 nCi mean initial alveolar depositions. Another group (20 dogs) served as controls. All dogs were about 18 months old. At the four highest exposure levels, a chronic lymphocytopenia developed which correlated with the initial alveolar plutonium burden in regard to magnitude of depression and time of development after exposure. The nadir occurred near 10 months after exposure in dogs receiving 5800, 1100, and 300 nCi, with corresponding lymphocyte levels 40, 55, and 75 percent, respectively, of those observed in control dogs. In the 80-nCi level the nadir occurred about 2 years after exposure at approximately 80 percent of control values. At the two lowest doses, i.e., 4 and 20 nCi, no effect on lymphocyte concentrations was noted 3 years after exposure. The persistent lymphocytopenia related to plutonium inhalation may be of significance in the subsequent development of pulmonary neoplasms previously observed in beagles at this laboratory 8 to 11 years after initial lung depositions of 200 to 1000 nCi of 239Pu

  16. Effect of low intensity pulsed ultrasound on repairing the periodontal bone of Beagle canines

    Institute of Scientific and Technical Information of China (English)

    Xiao-Qi Gu; Yong-Mei Li; Jing Guo; Li-Hua Zhang; Dong Li; Xiao-Dong Gai

    2014-01-01

    Objective: To investigate the repairing effect of low intensity pulsed ultrasound (LIPUS) on the Beagle canines periodontal bone defect. Methods: A total of 12 Beagle dogs with periodontal bone defect model were randomly divided into control group, LIPUS group, guided tissue regeneration (GTR) group and LIPUS+GTR group, with three in each. After completion of the models, no other proceeding was performed in control group; LIPUS group adopt direct exposure to radiation line LIPUS processing 1 week after modeling; GTR group adopted treatment with GTR, following the CTR standard operation reference; LIPUS+GTR group was treated with LIPUS joint GTR. Temperature change before treatment and histopathological change of periodontal tissue after repair was observed. Results: There was no significant difference in temperature changes of periodontal tissue between groups (P>0.05). The amount and maturity of LIPUS+GTR group were superior to other groups; new cementum, dental periodontal bones of GTR group were superior to the control group but less than LIPUS group; new collagen and maturity of the control group is not high relatively. Conclusions: LIPUS can accelerate the calcium salt deposition and new bone maturation, thus it can serve as promoting periodontal tissue repair, and shortening the periodontal tissue repair time.

  17. Microanalysis of oligosaccharide HS203 in beagle dog plasma by postcolumn fluorescence derivatization method.

    Science.gov (United States)

    Sun, Shumeng; Zhao, Xia; Li, Guangsheng; Yu, Guangli; Xing, Xiaoxu; Zeng, Yangyang; Wu, Jian; Wang, Jianing

    2012-06-20

    A rapid and sensitive postcolumn fluorescence derivatization method was developed for microanalysis of antidiabetic oligosaccharide HS203 in beagle dog plasma. After plasma protein was removed by a simple and fast ultrafiltration method, chromatographic separation was performed on an Asahipak GS-320 HQ column with a mobile phase of 50 mmol/L phosphate buffer (pH 6.7) and acetonitrile (83/17, v/v). The column effluent was monitored by fluorescence detection at 249 nm (excitation) and 435 nm (emission) using guanidine hydrochloride as a postcolumn derivatizing reagent. A satisfactory resolution of the analyte was achieved and the limit of detection was found to be 4 ng (more sensitive than silver staining of HS203 in polyacrylamide gel electrophoresis). The method described above was successfully applied to a pharmacokinetic study of HS203 and to monitor blood glucose level simultaneously in beagle dog. It is also possible to be applied for microanalysis of other oligosaccharides in biological samples. PMID:24750771

  18. Radiographic evaluation of obesity-caused oppression of the thoracic cavity in beagles

    International Nuclear Information System (INIS)

    Thoracic radiographs of fifteen beagles with mild-to-moderate obesity revealed that oppression of the thoracic cavity increased with increasing degree of obesity. Oppression of the thoracic cavity was evaluated based on the length, depth, width and area of the thoracic cavity. To obtain thoracic radiographs at the terminal inspiration and expiration phases, thoracic fluororadiographs were recorded with a digital video camera. Bodyweight and the depth of the back fat layer at the seventh lumbar vertebra (DB, measured by ultrasonography) were used as indicators of the degree of obesity. The length of the thoracic cavity tended to become shorter and the depth and width of the thoracic cavity tended to increase as bodyweight increased and as DB increased. On the other hand, the area of the thoracic cavity was not clearly related to bodyweight or DB. These results suggest that oppression of the thoracic cavity due to the cranial shift of the diaphragm is compensated for by increases in the depth and width of the thoracic cavity in beagles with mild-to-moderate obesity

  19. Age-related changes in the testes and prostate of the Beagle dog

    International Nuclear Information System (INIS)

    Age-related changes in the histologic morphology of the Beagle dog prostate and testes must be separated from those changes that may result from the testing of experimental compounds. The prostate and testes of healthy age-matched Beagle dogs 3 to 14 yr of age were obtained. Serum to evaluate testosterone levels was also obtained from each dog at the time of euthanasia. Tissue sections from the prostate and testes were examined by light microscopy for both qualitative and quantitative morphologic assessment. A statistically significant increase in prostatic weight with increased age was noted. Significant morphometric findings in the prostate included a decrease in the relative percent of epithelial cells and an increase in the relative lumen size of glandular acini with increased age. The absolute volume of prostate interstitial tissue and inflammation showed a statistically significant increase with age. Stereological analysis of the testes showed a decrease in the relative percent epithelium with increasing age. No distinct age-related trend could be detected in serum testosterone levels. Serum testosterone levels did not correlate with the morphologic age-related changes observed in the testes or prostate. (author)

  20. Occurrence of bone cancer among young adult Beagles given 239Pu

    International Nuclear Information System (INIS)

    Two hundred thirty-five young adult Beagles of both sexes were each given a single intravenous injection of 239Pu-citrate at graded dose-levels averaging about 0.026 to 106 kBq/kg when they were about 1 1/2 years of age and were maintained for lifespan observation. An additional 133 young adult Beagles of both sexes were entered into the experiment as control animals. All of these animals have now died or have been removed from the colony, and the occurrence of skeletal malignancies has been determined from histological examination. There were a total of 85 radiographically apparent malignant bone tumors in 77 dogs given 239Pu, and there was one control animal that developed a skeletal malignancy. Most of these were osteosarcomas, but there were seven chondrosarcomas of bone, one liposarcoma of bone, and in addition, there was one plasma cell myeloma and one ameloblastoma (admantinoma). Only those dogs that survived to at least the minimum latent period for death with radiation-induced bone sarcoma are included in the tabulation. There appeared to be a linear relationship between the percent of dogs with bone tumor and the average skeletal dose up to a dose of about 1 Gy. All dose-levels with skeletal doses of about 2 Gy and greater exhibited close to 100% occurrence

  1. Radiation injury of the developing immune system in the beagle dog

    International Nuclear Information System (INIS)

    Fetal lymphoid organs of the beagle dog were studied to determine if the developing immune system displays an age-dependent sensitivity to ionizing radiation. Pregnant beagle dams received abdominal 60Co gamma exposures to 200R or were sham irradiated at one of three ages in gestation; 35, 40, or 45 days postcoitus. The mean calculated dose to each fetus was 1.5 Gy. Half the fetuses in each litter were harvested by hysterotomy at five days and half at ten days postirradiation (PI). The volumes of the thymus lobules and lobular cortices were significantly reduced at five and ten days PI as compared to age matched controls. Radiation damage in the developing immune system was expressed in the lymphocyte populations of fetal lymphoid organs and in thymus epithelium. Damage was qualitatively and quantitatively more severe following irradiation earlier in gestation, confirming that the developing immune system displays an age-dependent sensitivity. Prenatal radiation injury to the developing lymphoid system could compromise postnatal immunologic function and could alter immunoregulation

  2. Pharmacokinetic and pharmacodynamic interactions of aspirin with warfarin in beagle dogs.

    Science.gov (United States)

    Shen, Chenlin; Huang, Xiaohui; Li, Jun; Zhang, Ping; Li, Lin; Zhang, Wei; Hu, Tingting; Pappoe, Faustina; Huang, Jihan; Tang, Haiqin

    2016-01-01

    1. Warfarin and aspirin are widely used in a wide spectrum of thromboembolic and atherothrombotic diseases. Despite the potential efficacy of warfarin-aspirin therapy, the safety and side effect of combined therapy remains unclear. 2. The aim of this study was to investigate the pharmacokinetic and pharmacodynamic interactions between warfarin and aspirin in beagles after single and multiple doses. 3. Coadministration of aspirin had no significant effects on the area under the plasma concentration time curve (AUC(0-t)) and maximum plasma concentration (Cmax) of R- and S-warfarin after a single dose of warfarin, but significantly increase the AUC(0-t) and Cmax and dramatically decrease the clearance (CL) of R- and S-warfarin after multiple dose of warfarin. Accordingly, there was a slight increase in the AUEC(0-t) and Emax of activated partial thromboplastin time (aPTT), prothrombin time (PT) and international normalized ratio (INR) after multiple dose of warfarin. 4. Coadministration of warfarin had no markedly effects on the AUC(0-t) and Cmax of aspirin and its metabolite salicylic acid after single or multiple dose of aspirin. Meanwhile, the AUEC(0-t) and Emax of inhibition of platelet aggregation (IPA) were not significantly affected by warfarin. 5. Our animal study indicated that coadministration of aspirin with warfarin can cause significant pharmacokinetic and pharmacodynamic drug-drug interactions in beagles. However, more studies are urgently needed to assess related information of warfarin-aspirin drug interactions in healthy volunteers or patients. PMID:26548565

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  11. Primeros ensayos petrofísicos sobre la roca dimensional de Tierra del Fuego First petrophysical trials over dimension stones of Tierra del Fuego

    Directory of Open Access Journals (Sweden)

    Rogelio Daniel Acevedo

    2011-06-01

    Full Text Available Se muestran aquí los primeros ensayos de laboratorio sobre las rocas dimensionales de Tierra del Fuego, región que tenía una potencialidad no evaluada respecto al uso posible de este recurso nativo. Nunca habían sido empleadas hasta ahora rocas duras (ígneas ni pizarras en la construcción residencial, el revestimiento de fachadas ó pisos. Dos pequeñas canteras de rocas plutónicas han sido abiertas recientemente: una de ellas en el cerro Jeu-Jepén, aprovechada para la construcción de la escollera marina del puerto de Río Grande y la ruta nacional, y la otra en la península de Ushuaia, iniciada con el propósito de remover un morro para localizar el aeropuerto y usada últimamente como revestimiento de viviendas. Sobre un grupo de muestras fueguinas se realizaron para este trabajo ensayos físicos de densidad aparente, absorción de agua y porosidad abierta, como asimismo ensayos mecánicos de resistencia a la compresión y a la tensión, y también algunos ensayos Dorry para medir su resistencia a la abrasión. En la Isla Grande de Tierra del Fuego los tipos más apropiados como rocas ornamentales han resultado ser las distintas variedades de rocas granitoides, con relativamente altas resistencias a la compresión y a la tensión. Las rocas del cerro Jeu-Jepén analizadas reúnen entonces las mejores condiciones para su aprovechamiento inmediato: buenos resultados petrofísicos, posibilidad de obtención de bloques de tamaño adecuado, descubrimiento de la cantera y fácil acceso.These are the first trials in laboratory over dimension stones of Tierra del Fuego. The Fuegian territory had a not evaluated potential respect of the possible use of this native resource. Neither hard rocks nor metamorphic rocks (slates have been applied ever for residential construction, facades and flooring in Fuegian buildings until now. Only in recent years, two little quarries of plutonic rocks have been opened. One of them in the Jeu-Jepen hill

  12. Epidemiología de las lesiones por mordedura de perro en Tierra del Fuego, Argentina Epidemiology of dog bite lesions in Tierra del Fuego, Argentina

    Directory of Open Access Journals (Sweden)

    Fabián Zanini

    2008-02-01

    Full Text Available La convivencia del hombre y el perro ha resultado en beneficios mutuos durante miles de años, si bien en el último tiempo han surgido una serie de inconvenientes donde las lesiones por mordeduras ocupan un lugar destacado. El objetivo del presente trabajo fue describir las características epidemiológicas de las lesiones por mordedura de perro ocurridas a lo largo de un año en Tierra del Fuego. Se realizó un estudio observacional descriptivo, transversal, de los pacientes que ingresaron con lesiones por mordedura de perro al Servicio de Guardia Clínica y Pediátrica de los Hospitales y Centros de Salud desde el 1/3/05 hasta el 1/3/06. Se confeccionaron 382 planillas. El 49.5% fueron niños resultando más afectado el grupo de 5-9 años (44.4%; IC95% 37.2-51.8. En adultos correspondió al grupo de 15-24 años (29.5%; IC95% 23.2-36.5. Se registraron más lesiones en varones (57.6% que en mujeres (42.4% (x² = 8.6, p= 0.003. En los meses primavera y verano se registró el 56.5% de las lesiones, en la vía pública el 72.8% de ellas. Los perros de tamaño grande causaron el 49.7% (IC95% 44.6-54.9 de las lesiones. El 89.8% de los ataques fueron causados por perros ajenos. El 55.8% (IC95% 50.6-60.8 se registró en miembros inferiores y el 11% (IC95% 8.1-14.7 en cabeza y cuello. Los datos obtenidos demuestran que en Tierra del Fuego las lesiones por mordedura de perro afectan en forma permanente la salud e impactan en la calidad de vida de la población.The coexistence between man and dog has resulted in mutual benefits during thousands of years, nevertheless some problems have recently arisen where bite injuries have an important role. The aim of this work was to describe the epidemiological characteristics of dog bite lesions which occurred during a year in Tierra del Fuego. A descriptive observational, transversal study of patients who were admitted with dog bite injuries to clinic and pediatric emergency services of hospitals and health

  13. Hifomicetes lignícolas de Tierra del Fuego (Fungi, Fungi Imperfecti, Hyphomycetales Hyphomycetes from Tierra del Fuego (Fungi, Fungi Imperfecti, Hyphomycetales

    Directory of Open Access Journals (Sweden)

    A. M. Godeas

    2007-07-01

    Full Text Available En este trabajo se investiga los hifomicetes en los bosques de Tierra del Fuego, que crecen sobre madera y corteza en diferentes estados de descomposición. Se incluye una clave de los géneros encontrados y cuando fue necesario una clave de las especies. Se identificaron 39 especies de las cuales 18 son primeras citas para la Argentina. Se realizan algunas consideraciones acerca de su importancia en el ecosistema.In this work, diversity and ditribution of Hyphomycetes growing in bark and wood in different degree of decomposition was study. Key of genera was included and when it was necessary, also key of species. At the end of this work, some consideration about the importance of this ecological group of fungi was made.

  14. Initial deposition and early clearance of inhaled 239Pu(NO3)4 aerosols in beagle dogs

    International Nuclear Information System (INIS)

    Data from exposures of 113 beagle dogs to 239Pu(NO3)4 aerosols were analyzed for effects of aerosol properties on deposition and early clearance. The percent of inhaled aerosols deposited was not significantly dependent on particle size or aerosol concentration. The early clearance rate was significantly slower at the highest exposure levels than at medium and low levels

  15. Effects of plutonium on the immune system: IgG in beagle dogs exposed to plutonium and in nonexposed controls

    International Nuclear Information System (INIS)

    Serum IgG levels in plutonium-oxide-exposed and unexposed beagle dogs was assayed with the Mancini system. With this system, there was no significant difference between IgG levels of exposed dogs and controls, nor among exposed dogs with different degrees of lymphopenia. (U.S.)

  16. Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs.

    Science.gov (United States)

    Liu, Hui; Wang, Ya-Jing; Yang, Lei; Zhou, Mei; Jin, Man-Wen; Xiao, Guo-Sheng; Wang, Yan; Sun, Hai-Ying; Li, Gui-Rong

    2016-01-01

    We previously reported that duodenal administration of the natural flavone acacetin can effectively prevent the induction of experimental atrial fibrillation (AF) in canines; however, it may not be used intravenously to terminate AF due to its poor water-solubility. The present study was to design a water-soluble prodrug of acacetin and investigate its anti-AF effect in beagle dogs. Acacetin prodrug was synthesized by a three-step procedure. Aqueous solubility, bioconversion and anti-AF efficacy of acacetin prodrug were determined with different methodologies. Our results demonstrated that the synthesized phosphate sodium salt of acacetin prodrug had a remarkable increase of aqueous solubility in H2O and clinically acceptable solution (5% glucose or 0.9% NaCl). The acacetin prodrug was effectively converted into acacetin in ex vivo rat plasma and liver microsome, and in vivo beagle dogs. Intravenous infusion of acacetin prodrug (3, 6 and 12 mg/kg) terminated experimental AF without increasing ECG QTc interval in beagle dogs. The intravenous LD50 of acacetin prodrug was 721 mg/kg in mice. Our preclinical study indicates that the synthesized acacetin prodrug is highly water-soluble and safe; it effectively terminates experimental AF in beagle dogs and therefore may be a promising drug candidate for clinical trial to treat patients with acute AF. PMID:27160397

  17. Triple antibiotic paste in root canal therapy

    Directory of Open Access Journals (Sweden)

    Rangasamy Vijayaraghavan

    2012-01-01

    Full Text Available The success of the endodontic treatment depends on the microbial suppression in the root canal and periapical region. Endodontic instrumentation alone cannot achieve a sterile condition. With the advent of non-instrumentation endodontic treatment and lesion sterilization and tissue repair, local application of antibiotics has been investigated. Triple antibiotic paste (TAP containing metronidazole, ciprofloxacin, and minocycline has been reported to be a successful regimen in controlling the root canal pathogen and in managing non-vital young permanent tooth. This paper reviews the existing literature on biocompatibility, efficiency, drawbacks of TAP in endodontic therapy and pulp revascularization.

  18. Stratification and enumeration of Boolean functions by canalizing depth

    Science.gov (United States)

    He, Qijun; Macauley, Matthew

    2016-01-01

    Boolean network models have gained popularity in computational systems biology over the last dozen years. Many of these networks use canalizing Boolean functions, which has led to increased interest in the study of these functions. The canalizing depth of a function describes how many canalizing variables can be recursively "picked off", until a non-canalizing function remains. In this paper, we show how every Boolean function has a unique algebraic form involving extended monomial layers and a well-defined core polynomial. This generalizes recent work on the algebraic structure of nested canalizing functions, and it yields a stratification of all Boolean functions by their canalizing depth. As a result, we obtain closed formulas for the number of n-variable Boolean functions with depth k, which simultaneously generalizes enumeration formulas for canalizing, and nested canalizing functions.

  19. [Frequency and most common localisation of root canal curvature].

    Science.gov (United States)

    Blasković-Subat, V

    1991-01-01

    The root canal therapy of the curved canals is a complex operative procedure. Therefore 260 root canals were analysed radiologically to determine the frequency and the most common localisation of the root canal curvature. The frequency of the curved canals averaged at 59%, being greater in the sample of posterior than in the anterior teeth (p less than 0.05). The root canal curvature was most frequently localised at the apical third part (53.9%), followed by the cervical (33.3%) and the middle (12.8%) third part. The apical curvature was predominant in the sample of the anterior, while the cervical predominant (45.2%) in the sample of the posterior teeth. This study pointed out that the frequency of the curved canals is rather high. Consequently, the necessity for practising the modern root canal preparation techniques, bearing in mind their potential danger, is emphasized. PMID:1819932

  20. Stratification and enumeration of Boolean functions by canalizing depth

    CERN Document Server

    He, Qijun

    2015-01-01

    Boolean network models have gained popularity in computational systems biology over the last dozen years. Many of these networks use canalizing Boolean functions, which has led to increased interest in the study of these functions. The canalizing depth of a function describes how many canalizing variables can be recursively picked off, until a non-canalizing function remains. In this paper, we show how every Boolean function has a unique algebraic form involving extended monomial layers and a well-defined core polynomial. This generalizes recent work on the algebraic structure of nested canalizing functions, and it yields a stratification of all Boolean functions by their canalizing depth. As a result, we obtain closed formulas for the number of n-variable Boolean functions with depth k, which simultaneously generalizes enumeration formulas for canalizing, and nested canalizing functions.

  1. Loss of helminth species diversity in the large hairy armadillo Chaetophractus villosus on the Tierra del Fuego Island, Argentina.

    Science.gov (United States)

    Ezquiaga, M C; Abba, A M; Navone, G T

    2016-03-01

    The aim of this work is to compare the taxonomic diversity of parasite species of the large hairy armadillo Chaetophractus villosus in its native range and in another recently introduced population (Tierra del Fuego island), and to evaluate whether the isolation of the latter determines a decrease in its parasitic diversity. Forty specimens from Buenos Aires and Tierra del Fuego Provinces were collected and examined for helminths. Eleven parasite species were found in the native population, and only one species was present in Tierra del Fuego (Trichohelix tuberculata). This may be explained because isolation and climatic conditions prevent encounters between potential host species and infective forms of parasites. Further sampling will be needed throughout the entire Patagonia steppe to confirm how the characteristic parasitic fauna of C. villosus behaves across the armadillo's southern distribution. PMID:25673233

  2. [Tierra del Fuego: the scientific-political construction of exclusion and counter-image of the ideal city dweller].

    Science.gov (United States)

    Nacach, Gabriela

    2012-01-01

    Due to its late incorporation into the national State, the social, economic and political setting of the Argentine province Tierra del Fuego differed from that of the rest of the national territory. In the construction of dependent otherness, objectifications and representations were imposed by state-related and non-state-related institutions, among other agencies. In this context, the Salesian mission of La Candelaria and Ushuaia's Jail for recidivists stand out as spaces in which biopolitics was concretised. The native population and criminals in Tierra del Fuego were those to be subjugated. The thesis of the extinction of the Indian and the simultaneous exaltation of the criminal as the subject of progress identified the scientific and political mechanisms by which the exclusion of certain social groups (Tierra del Fuego's indigenous population) and the inclusion of others (criminals) were regulated. PMID:22849216

  3. Reduction of Enterococcus faecalis in curved root canals after various sizes and tapers of canal preparation

    OpenAIRE

    Amir Abbas Moshari; Nahid Mohammadzadeh Akhlaghi; Nahid Rahimifard; Soheila Darmiani

    2015-01-01

    Aims: The aim of this study was to evaluate the reduction of Enterococcus faecalis in curved root canals after various sizes and tapers of the canal preparation. Materials and Methods: Mandibular first molars (n = 103) with curved mesiobuccal canals were divided into one control (n = 5) and 7 experimental (n = 14) groups, were inoculated with E. faecalis (ATTC 29212) and prepared with the following RaCe files (FKG Dentaire) as master apical file: Groups: 25.04, 25.06, 30.04, 30.06, 35.04,...

  4. Spectral variability on primitive asteroids of the Themis and Beagle families: Space weathering effects or parent body heterogeneity?

    Science.gov (United States)

    Fornasier, S.; Lantz, C.; Perna, D.; Campins, H.; Barucci, M. A.; Nesvorny, D.

    2016-05-01

    Themis is an old and statistically robust asteroid family populating the outer main belt, and resulting from a catastrophic collision that took place 2.5 ± 1.0 Gyr ago. Within the old Themis family a young sub-family, Beagle, formed less than 10 Myr ago, has been identified. We present the results of a spectroscopic survey in the visible and near infrared range of 22 Themis and 8 Beagle families members. The Themis members investigated exhibit a wide range of spectral behaviors, including asteroids with blue/neutral and moderately red spectra, while the younger Beagle family members look spectrally bluer than the Themis ones and they have a much smaller spectral slope variability. Four Themis members, including (24) Themis, have absorption bands centered at 0.68-0.73 μm indicating the presence of aqueously altered minerals. The best meteorite spectral analogues found for both Themis and Beagle families members are carbonaceous chondrites having experienced different degrees of aqueous alteration, prevalently CM2 but also CV3 and CI, and some of them are chondrite samples being unusual or heated. The presence of aqueous altered materials on the asteroids surfaces and the meteorite matches indicate that the parent body of the Themis family experienced mild thermal metamorphism in the past. We extended the spectral analysis including the data available in the literature on Themis and Beagle families members, and we looked for correlations between spectral behavior and physical parameters using the albedo and size values derived from the WISE data. The analysis of this larger sample confirms the spectral diversity within the Themis family and that Beagle members tend to be bluer and to have an higher albedo. The differences between the two families may be partially explained by space weathering processes, which act on these primitive surfaces in a similar way than on S-type asteroids, i.e. producing reddening and darkening. However we see several Themis members

  5. Mapa de usos potenciales de la tierra de Galicia. Una perspectiva arqueológica

    Directory of Open Access Journals (Sweden)

    Currás Refojos, Brais X.

    2014-06-01

    Full Text Available A digital version of the map of potential land use of Galicia is here presented, adapted to a reclassification of three types of potential land use, established using historical criteria. An analytical procedure is developed to select the land-types and the system used for their digitalisation. In the final part the map is used to critically revise the possibilities of using this record for territorial characterisation in archaeological research.La cartografía de usos potenciales de la tierra es una herramienta de gran utilidad en el estudio de las formas de poblamiento y su relación con la explotación de los recursos agrícolas desde el enfoque de la arqueología del paisaje. La digitalización de esta información permite su aplicación sistemática en el análisis del territorio mediante SIG. En este trabajo se presenta el Mapa de usos potenciales de la tierra de Galicia, reclasificado en tres tipos establecidos en función de criterios históricos. Se muestra el procedimiento analítico desarrollado para la selección y clasificación de los tipos de tierra y su sistema de digitalización. Se examina la validez de esta fuente para la investigación arqueológica de las formas agrícolas en la antigu.edad desde el punto de vista del análisis del territorio y se ofrece una visión crítica sobre sus ventajas y limitaciones.

  6. Iniciación en investigación de arquitectura de tierra cruda : FAU - UNT

    OpenAIRE

    Sosa, Mirta Eufemia; Latina, Stella Maris

    2015-01-01

    En la Facultad de Arquitectura y Urbanismo (FAU) de la Universidad Nacional de Tucumán (UNT), la formación de arquitecto se desarrolla en cincos niveles que se implementan en tres ciclos de grado y en cuatros áreas de contenidos: Comunicación y Forma; Proyecto y Planeamiento; Ciencias Básicas, Tecnología, Producción y Gestión e Historia y Teoría. En el marco del área de Tecnología el Centro Regional de Investigaciones de Arquitectura de Tierra Cruda (CRIATiC), desarrolla actividades en el ...

  7. Crecimiento de Colossoma macropomum en estanques de tierra en dependencia de la densidad.

    OpenAIRE

    Jorge Günther; Jorge Boza; Nazira Gálvez

    2016-01-01

    Se analiza el crecimiento y la utilización de alimento del tambaquí, Colossoma macropomum, cultivado a densidades de 0,5, 1 y 2 peces/m2 en estanques de tierra de 60m2 con alimento balanceado con 35% proteína. No se encontraron diferencias estadísticas significativas con respecto a la densidad. Sin embargo, el crecimiento obtenido fue mucho menor que en otro ensayo realizado en las mismas condiciones y simultáneamente en un estanque de 3000 m2, por lo que se discute la hipótesis de que el cre...

  8. El regreso de los judíos hispanos a Tierra Santa

    OpenAIRE

    Cantera Montenegro, Enrique

    2004-01-01

    Tras un breve análisis acerca del lugar que la ciudad de Jerusalén y la Tierra Prometida ocupan en el judaismo y en la conciencia colectiva del pueblo judío, y del papel que la Ciudad Santa desempeña como meta de los peregrinos judíos, se estudian los movimientos de migración de los judíos hispanos hacia Palestina, a lo largo de la Edad Media y hasta el siglo XVII Añera brief analysis about the importance of Jerusaiem and the Promised Land in the Judaism and i...

  9. Los latidos de la tierra: Arte ecológico para acompasar nuestros ritmos

    OpenAIRE

    Soler Ruiz, Mª Isabel; Soto Sánchez, Pilar

    2014-01-01

    Desde nuestros orígenes el ser humano ha respetado su entorno por propia supervivencia. Salvo algunas culturas que aún sobreviven en su ambiente original, nos hemos ido alejando del latido de la tierra. El arte, como una acción ecológica más, puede ayudarnos a despertar nuestras conciencias. Desde finales del siglo XIX hasta mediados de los sesenta se han ido gestando movimientos ecológicos en defensa del espacio natural y acciones de sostenibilidad dentro del espacio urb...

  10. Problemas ambientales detectados por la población de Ushuaia (Tierra del Fuego, Argentina)

    OpenAIRE

    María Gabriela Orzanco

    1999-01-01

    Ushuaia, capital de la provincia de Tierra del Fuego. es una ciudad que ha experimentado un crecimiento poblacional intenso en un ambiente con restricciones físicas y biológicas, por lo que se han manifestado numerosos problemas ambientales. Este trabajo pretende conocer la imagen que de la ciudad tienen los habitantes de sus diferentes zonas. Se elaboró un cuestionario que se distribuyó en siete zonas de la ciudad. A partir de 114 cuestionarios completos recogidos se puede concluir que la...

  11. Primeros ensayos petrofísicos sobre la roca dimensional de Tierra del Fuego

    OpenAIRE

    Rogelio Daniel Acevedo; Mauricio González-Guillot

    2011-01-01

    Se muestran aquí los primeros ensayos de laboratorio sobre las rocas dimensionales de Tierra del Fuego, región que tenía una potencialidad no evaluada respecto al uso posible de este recurso nativo. Nunca habían sido empleadas hasta ahora rocas duras (ígneas) ni pizarras en la construcción residencial, el revestimiento de fachadas ó pisos. Dos pequeñas canteras de rocas plutónicas han sido abiertas recientemente: una de ellas en el cerro Jeu-Jepén, aprovechada para la construcción de la escol...

  12. “Caminando sobre la tierra, de nuevo desconocida, toda cambiada”

    OpenAIRE

    Russo, Alessandra

    2012-01-01

    La producción de mapas por parte de los cartógrafos indígenas, mestizos y españoles en los siglos XVI y XVII, es un laboratorio de increíble riqueza para estudiar los efectos pictóricos que la transformación territorial-administrativa empezada por la conquista tuvo al pasar por la esfera de la creación. En las imágenes, hoy en el Archivo General de la Nación, los pintores locales tuvieron que inventar una nueva forma de visualizar las tierras, los espacios y los paisajes. De esta mina inagota...

  13. El antiguo cementerio de la mision de Río Grande, Tierra del Fuego

    OpenAIRE

    García Laborde, Pamela; Suby, Jorge A.; Guichón, Ricardo Aníbal; Casali, Romina

    2010-01-01

    En el marco del proceso de contacto interétnico ocurrido hacia fines del siglo XIX y principios del XX en Tierra del Fuego, lo acontecido específicamente en la misión salesiana La Candelaria (Rio Grande) cobra relevancia por la variedad de registros y fuentes que dicho escenario ofrece. La aproximación historiográfica permitió generar información acerca de la presencia de tuberculosis como causa principal de muerte entre los aborígenes que vivieron en la misión y sobre la dieta, la actividad ...

  14. Enfermedades infecciosas probablemente dispersadas por los europeos durante el contacto indirecto en Tierra del Fuego

    OpenAIRE

    Fugassa, Martín H.; Guichón, Ricardo Aníbal

    2003-01-01

    Para la colonización de Norteamérica, ciertos autores sugieren que enfermedades infecciosas actuaron de modo discreto durante un período inicial llamado de Contacto Indirecto. Ello implicaría que los registros históricos con que contamos describan sociedades transformadas. Para Tierra del Fuego, Borrero establece la incertidumbre sobre el tamaño de las poblaciones previas a los primeros relatos de Gusinde y otros. Pretendemos brindar un marco probabilístico sobre las enfermedades infecciosas ...

  15. Nuevas determinaciones de isótopos estables para Tierra del Fuego

    OpenAIRE

    Guichón, Ricardo Aníbal; Borrero, Luis Alberto; Prieto, Luis A.; Cárdenas, Pedro; Tykot, Robert

    2001-01-01

    Se presentan los resultados del análisis de isótopos estables (d 13C y d 15N sobre colágeno, d 13C sobre apatita) de 8 muestras óseas procedentes de Tierra del Fuego que, junto con 15 determinaciones previas, informan sobre la variación en la subsistencia de poblaciones de cazadores-recolectores. Se observa que los valores más "marítimos" se encuentran en el conjunto Sudeste de la Isla Grande. Por otra parte, los más "continentales" se encuentran en el conjunto Norte de la Isla Grande. Es int...

  16. Holocene paleoclimate characterization in Lago Fagnano (Tierra del Fuego) using sedimentary, physical and geochemical proxies

    Science.gov (United States)

    Vizcaino Marti, A.; Dunbar, R. B.; Wahl, D.; Moy, C. M.; Mucciarone, D. A.; Anderson, L.; Guilderson, T. P.

    2010-12-01

    Tierra del Fuego is the world's southernmost landmass outside of Antarctica. Two features of ocean circulation control the climate of Tierra del Fuego: the Southern Ocean circumpolar flow and the South Pacific Gyre. Together with Patagonia, Tierra del Fuego is the only terrestrial region directly influenced by the southern hemisphere westerly winds. This region is also a tectonically active area affected by volcanic and seismic activity related to South American and Scotia-Antarctic plate boundaries. Accommodated along the Magallanes-Fagnano fault system, as part of the plate boundary, the Lago Fagnano is the largest lake in Tierra del Fuego. This E-W trending lake is 100 km long and 5-15 km wide. Our investigations were carried out on the upper 4 meters of an 8.4 m long piston core obtained at 69 m water depth in Bahía Grande (LF06-PC8); a southwestern lake sub-basin separated from the main lake by a shallow sill. Our studies are based on the integration of sediment description, physical properties, pollen, and geochemical analyses including C and N isotopes (1cm interval) and XRF scan (1mm interval). The age model for the core is based on radiocarbon ages and tephrochronology. Additionally, a 800 km long grid of high resolution seismic profiles support the sedimentary analyses and allow the correlation with other cores from within the lake basin. LF06-PC8 yields continuous and high accumulation-rate sedimentary sections for Lago Fagnano. The presented sediment record corresponds to a laminated hemipelagite with presence of a single but complex mass transport deposit interval. An accurate sedimentological interpretation of the core together with the radiocarbon ages and tephra dates allow to identify and characterize the main sedimentary processes occurring in the lake over the last 8 kyr. In addition, proxy data (C and N isotopes and XRF scan data) from the laminated hemipelagic interval provide a reliable record of past variability in the westerly wind field as

  17. Estudios arqueológicos en San Julio 2 (Tierra del Fuego)

    OpenAIRE

    Victoria D. Horwitz; Borrero, Luis Alberto; Casiraghi , Marcela

    1994-01-01

    Este trabajo presenta la información de las excavaciones del locus San Julio 2, ubicado en el interior de la estepa del norte de Tierra del Fuego. Se describen y discuten los conjuntos óseo, y de artefactos, así también como las huellas de corte, patrones de trozamiento, y tafonomía. Por último, se evalúa el locus desde la perspectiva de las contribuciones a la historia del contacto, a los estudios de movilidad y subsistencia prehistóricas, y a las investigaciones arqueológicas de sitios simi...

  18. LA RESTITUCIÓN DE TIERRAS EN COLOMBIA EXPECTATIVAS Y RETOS

    OpenAIRE

    Claudia Margarita Martínez Sanabria; Andrea Carolina Pérez Forero

    2012-01-01

    Se pretende hacer un estudio de la obligación a cargo del Estado Colombiano de restituir las tierras que les han sido arrebatadas a los desplazados-víctimas del conflicto armado, como parte de la obligación de reparación integral. Dentro de éste contexto se analizará el problema del desplazamiento forzado interno en Colombia a partir de sus antecedentes e identificación de los derechos de los desplazados y la regulación y jurisprudencia que se ha expedido en la materia. Así mismo, se analizar...

  19. Los dilemas de la restitución de tierras en Colombia

    OpenAIRE

    Rodrigo Uprimny-Yepes; Nelson Camilo Sánchez

    2010-01-01

    El texto sostiene que si bien existen algunos encuentros estratégicos en el tema de tierras en distintos sectores de la sociedad, los cuales confluyen en el tema específico de la restitución, también existen diametrales desacuerdos sobre el tema. Por un lado, están quienes abogan por una “restitución fina”, y respaldan entonces una política de restitución que se concentre en corregir la ilegalidad del despojo y aclarar los títulos y los derechos individuales sobre los bienes, lo cual serviría...

  20. El poblamiento de la edad del cobre en la tierra llana de Huelva

    OpenAIRE

    Pérez Macías, Juan Aurelio; Gómez Toscano, Francisco; Campos Carrasco, Juan Manuel

    2010-01-01

    Se presentan en este trabajo los resultados del Proyecto Tierra Llana de Huelva referidos a la ocupación de la Edad del Cobre. Proponemos una permanencia del sistema del poblamiento durante el Calcolítico y Bronce Pleno, y su ruptura hacia el Bronce Final, periodo en el que se estructura el territorio en turno a centros hegemónicos.____________________________They are presented in this work the results of the project Flat Earth of Huelva referred to the occupation of the Copper Age. We pro...

  1. El Reverendo Padre Bonaventura Ubach, peregrino en Tierra Santa: el monje y su obra

    Directory of Open Access Journals (Sweden)

    Valdés Pereiro, Carmen

    2005-04-01

    Full Text Available Se estudia aquí la figura de un religioso benedictino del Monasterio de Montserrat, el padre Bonaventura Ubach, que dedicó gran parte de su vida al estudio de la Biblia. Para conocer mejor el libro sagrado realizó numerosos viajes por Tierra Santa y Mesopotamia durante los primeros decenios del siglo XX. La documentación recogida durante sus viajes le permitiría realizar dos de sus más importantes obras: la ilustración de la Biblia de Montserrat y la creación del Museo Bíblico.…

  2. MERCADO DE TIERRAS Y PROPIEDAD SOCIAL: UNA DISCUSIÓN ACTUAL

    OpenAIRE

    Plata Vázquez, José Luis; Instituto de Investigaciones Antropológicas

    2014-01-01

    No es posible abarcar la complejidad del mercado de tierras desde una sola perspectiva pues los aspectos relacionados con ella son siempre diversos y dependen de factores como la ubicación geográfica de cada pueblo por estudiar, la cultura de los habitantes del medio rural y las políticas agrarias que aplica el gobierno; no obstante, en un intento por contribuir en la comprensión de este fenómeno, el presente análisis incluye algunas ideas desarrolladas hasta el momento en torno a los concept...

  3. Las normativas de construcción con tierra en el mundo

    Directory of Open Access Journals (Sweden)

    Cid, J.

    2011-09-01

    Full Text Available For centuries, earth has been used as a construction material. Nevertheless, the normative in this matter is very scattered, and in the most developed countries, carrying out a construction with this material implies a variety of technical and legal problems. This article analyzes, in an international level, the normative panorama about constructions with earth, analyzing fifty five standards and regulations of countries all around the five continents; these represent the state of art that normalizes the earth as a construction material. It is a study indexed on the actual procedures and regulations developed by the national organisms of normalization or correspondent authorities. The standards and the organisms that produce them appear, analyzing the structure and the content of each one. We have studied and analyzed the most relevant aspects, such as stabilization, soil selections, the requisites of the products and the existent test, comparing the diverse normative. The knowledge from this study could be very useful for the development of future standards and as a reference for architects and engineers that work with earth.

    La tierra ha sido utilizada como material de construcción desde hace siglos. No obstante, la normativa al respecto está muy dispersa, y en la mayoría de países desarrollados surgen numerosos problemas técnicos y legales para llevar a cabo una construcción con este material. Este artículo estudia el panorama normativo para las construcciones con tierra cruda a nivel internacional, analizando cincuenta y cinco normas y reglamentos de países repartidos por los cinco continentes, que representan el estado del arte de la normalización de la tierra cruda como material de construcción. Es un estudio referenciado sobre las normas y reglamentos vigentes desarrollados por los organismos nacionales de normalización o autoridades correspondientes. Se presentan las normativas y los organismos que las emiten

  4. Los satélites de observación de la tierra en el 2000

    OpenAIRE

    Denore, Bernard J.; López García, María José

    1999-01-01

    Este artículo presenta las tendencias actuales en los satélites de observación de la tierra, a partir del análisis de las series operativas, los satélites de reciente lanzamiento y programas en preparación. Se detallan cinco tipos de misiones: la nueva generación de sistemas meteorológicos, las misiones científicas de las grandes agencias espaciales, los sistemas ya operativos para la cartografía de recursos (Landsat, SPOT, IRS...), los nuevos sistemas comerciales de muy alta resolución y, f...

  5. 21 CFR 872.3820 - Root canal filling resin.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Root canal filling resin. 872.3820 Section 872...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3820 Root canal filling resin. (a) Identification. A root canal filling resin is a device composed of material, such as methylmethacrylate,...

  6. Newer Root Canal Irrigants in Horizon: A Review

    OpenAIRE

    Prashant P. Jaju; Sushma Jaju

    2011-01-01

    Sodium hypochloride is the most commonly used endodontic irrigant, despite limitations. None of the presently available root canal irrigants satisfy the requirements of ideal root canal irrigant. Newer root canal irrigants are studied for potential replacement of sodium hypochloride. This article reviews the potential irrigants with their advantages and limitations with their future in endodontic irrigation.

  7. Newer Root Canal Irrigants in Horizon: A Review

    Directory of Open Access Journals (Sweden)

    Sushma Jaju

    2011-01-01

    Full Text Available Sodium hypochloride is the most commonly used endodontic irrigant, despite limitations. None of the presently available root canal irrigants satisfy the requirements of ideal root canal irrigant. Newer root canal irrigants are studied for potential replacement of sodium hypochloride. This article reviews the potential irrigants with their advantages and limitations with their future in endodontic irrigation.

  8. Computed tomography of the thoracic canal. Experimental and clinical studies

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, S. (Yamaguchi Univ., Ube (Japan). School of Medicine)

    1981-05-01

    Under the adequate CT condition, thoracic canal was studied in twelve normal cases, nine cases of cervical myelopathy with developmental cervical canal stenosis and four cases of thoracic myelopathy with ossification of thoracic yellow ligament. The results were as follows. 1) The adequate condition for delineation of thoracic canal seemed to be nearly 400 EMI units in window width and 150 in level. Scanning angle was permitted within about 10/sup 0/. Bony thoracic canal was well scanned at the center of vertebral body. 2) The configulation of the normal thoracic canal was oval at Th/sub 1/, Th/sub 2/ levels and round at Th/sub 3/-Th/sub 10/ and large oval at Th/sub 11/, Th/sub 12/. The sagittal diameter was almost fixed at each level and the transverse diameter was large at upper and lower levels and small at middle levels. 3) Thoracic canal was narrowed in the cases of cervical myelopathy with developmental cervical canal stenosis especially in sagittal diameter, but not narrowed in transverse diameter. Three of four cases who had myelopathy with ossification of thoracic yellow ligament had narrow canals. 4) There was a good relation between sagittal diameter of cervical canal and thoracic canal. 5) There was a good relation between sagittal diameter of thoracic canal measured by conventional radiographs (Hattori's method) and CT scans. The author thinks that Hattori's method is useful to diagnose the thoracic canal stenosis.

  9. El frente de pueblos en defensa de la tierra (FPDT) y la violencia de género.

    OpenAIRE

    Carrillo Franco, Blanca Estela

    2010-01-01

    En esta investigación se muestra que el Estado ante la crisis hegemónica por la que atraviesa criminaliza a los movimientos sociales que disienten del “orden establecido”. Es el caso del Frente de Pueblos en Defensa de la Tierra (FPDT). El Estado mexicano ha optado por reprimirlo y judicializarlo. La represión estatal a dicho movimiento es añeja, desde que surgió ante la inminente expropiación de sus tierras, el 22 de octubre de 2001, las personas del FPDT han vivido la violencia del brazo re...

  10. El modelo sol-tierra-luna en el lenguaje iconográfico de estudiantes de magisterio

    OpenAIRE

    Gil Quílez, M. José; Martínez Peña, M. Begoña

    2005-01-01

    Las ilustraciones que acompañan a los textos no siempre facilitan el proceso de aprendizaje. En este trabajo se estudian las representaciones gráfi cas y los textos que acompañan a las mismas, realizadas por estudiantes de Magisterio sobre los movimientos de la Tierra y de la Luna y sus consecuencias. Su análisis permite afi rmar que hay una falta de comprehensión del modelo Sol-Tierra-Luna. Así mismo los estudiantes tienen severas dificultades en expresarse mediante dibujos. Hay que evitar e...

  11. Una nueva forma de concentración de la tierra en Colombia:la ley 1448 de 2011

    OpenAIRE

    Jhon Jair González Pulgarín; Juan Pablo Henao Guzmán

    2012-01-01

    En este artículo se pretende mostrar, mediante un análisis económico, cómo la Ley 1448 de 2011 (o Ley de Víctimas y Restitución de Tierras), junto al Plan Nacional de Desarrollo (PND) 2011-2014, generan concentración de la tierra en Colombia. Esto se debe a que los objetivos del PND terminan disgregando los que busca la Ley 1448, lo cual se explica con el uso de un modelo de agencia y el subsecuente problema de riesgo moral para el Estado y las víctimas del conflicto. A partir de los resultad...

  12. La territorialidad del indígena americano de la tierra alta del norte de la Baja California

    OpenAIRE

    Ralph Michelsen

    1991-01-01

    Ralph Michelsen explora la idea de territorialidad entre los indígenas de Baja California como sujetos de otro tipo de realidad; un tiempo cuando el usufructo de la tierra se ceñía a reglas aborígenes particulares en contraste con las formas de tenencia de la tierra actuales y la noción de "país" que en el mundo prevalece. Su finalidad se logra mediante una reconstrucción histórica que le permite hacer propuestas sobre la percepción del espacio geográfico por los miembros de unidades lingüíst...

  13. Nerve canals at the fundus of the internal auditory canal on high-resolution temporal bone CT

    Energy Technology Data Exchange (ETDEWEB)

    Ji, Yoon Ha; Youn, Eun Kyung; Kim, Seung Chul [Sungkyunkwan Univ., School of Medicine, Seoul (Korea, Republic of)

    2001-12-01

    To identify and evaluate the normal anatomy of nerve canals in the fundus of the internal auditory canal which can be visualized on high-resolution temporal bone CT. We retrospectively reviewed high-resolution (1 mm thickness and interval contiguous scan) temporal bone CT images of 253 ears in 150 patients who had not suffered trauma or undergone surgery. Those with a history of uncomplicated inflammatory disease were included, but those with symptoms of vertigo, sensorineural hearing loss, or facial nerve palsy were excluded. Three radiologists determined the detectability and location of canals for the labyrinthine segment of the facial, superior vestibular and cochlear nerve, and the saccular branch and posterior ampullary nerve of the inferior vestibular nerve. Five bony canals in the fundus of the internal auditory canal were identified as nerve canals. Four canals were identified on axial CT images in 100% of cases; the so-called singular canal was identified in only 68%. On coronal CT images, canals for the labyrinthine segment of the facial and superior vestibular nerve were seen in 100% of cases, but those for the cochlear nerve, the saccular branch of the inferior vestibular nerve, and the singular canal were seen in 90.1%, 87.4% and 78% of cases, respectiveIy. In all detectable cases, the canal for the labyrinthine segment of the facial nerve was revealed as one which traversed anterolateralIy, from the anterosuperior portion of the fundus of the internal auditory canal. The canal for the cochlear nerve was located just below that for the labyrinthine segment of the facial nerve, while that canal for the superior vestibular nerve was seen at the posterior aspect of these two canals. The canal for the saccular branch of the inferior vestibular nerve was located just below the canal for the superior vestibular nerve, and that for the posterior ampullary nerve, the so-called singular canal, ran laterally or posteolateralIy from the posteroinferior aspect of

  14. The crazy project – Canal Istanbul

    Directory of Open Access Journals (Sweden)

    Seda Kundak

    2011-10-01

    Full Text Available It was late April 2011 when “the Crazy Project - Canal Istanbul” was proposed by the Prime Minister of Turkey, during his election campaign.  Although the idea of an artificial canal is not new, since it is initiated without any consensus between the people and institutions in Istanbul, the project immediately set a large number of debates. These vary from the legitimacy of decentralization of governance, to potential impacts of the canal on international politics, economy, environment and urban life.  Regarding past infrastructure projects in Istanbul, such large scale investments have caused extensive acceleration in construction sector in one hand and social and economic shifts on the other.  In this paper, the Canal Istanbul Project is evaluated according to basic motivations and claims of the PM, multi-perspective view through challenges and limitation that the project is likely to face with and speculations on implementation approach. The final discussion on the project is based on benefits/losses of Istanbul once the project will be implemented.

  15. Root canal treatment in necrotic primary molars.

    Science.gov (United States)

    Reyes, A D; Reina, E S

    1989-01-01

    Fifty-three patients (27 boys and 26 girls) with necrotic primary teeth received root canal treatments with a paste consisting of KRI-1 paste and pure calcium hydroxide powder with one drop of formocresol. All cases were followed clinically, radiographically and some histologically at 6, 12 and 17 to 24 months postoperatively. All cases were clinically and radiographically successful. PMID:2637358

  16. Infrared tympanic temperature and ear canal morphology

    NARCIS (Netherlands)

    Daanen, H.A.M.

    2006-01-01

    Several publications indicate that the infrared tympanic temperature (IRTT) underestimates the core temperature of the body when the ear canal is long, curvy and narrow. In order to quantify these observations, a study was performed in 10 subjects. The IRTT was determined and compared to the oesopha

  17. Study of four week repeated dose toxic test of Sweet Bee Venom in Beagle Dogs

    Directory of Open Access Journals (Sweden)

    Jae-Seuk Park

    2010-12-01

    Full Text Available Objectives: This study was performed to analyse four week repeated dose toxicity of Sweet Bee Venom(Sweet BV extracted from the bee venom in Beagle dogs. Methods: All experiments were conducted under the regulations of Good Laboratory Practice (GLP at Biotoxtech Company, a non-clinical study authorized institution. Male and female Beagle dogs of 5-6 months old were chosen for the pilot study of four week repeated dose toxicity of Sweet BV which was administered at the level of 0.56㎎/㎏ body weight which is eighty times higher than the clinical application dosage as the high dosage, followed by 0.28 and 0.14㎎/㎏ as midium and low dosage, respectively. Equal amount of excipient(normal saline to the Sweet BV experiment groups was administered as the control group every day for four weeks. Results: 1. No mortality was witnessed in all of the experiment groups. 2. All experiment groups were appealed pain sense in the treating time compared to the control group, and hyperemia and movement disorder were observed around the area of administration in all experiment groups, and higher occurrence in the higher dosage treatment. 3. For weight measurement, Neither male nor female groups showed significant changes. 4. In the urine analysis, CBC and biochemistry didn't show any significant changes in the experiment groups compared with control group. 5. For weight measurement of organs, experiment groups didn't show any significant changes compared with control group. 6. To verify abnormalities of organs and tissues, thigh muscle which treated with Sweet BV, cerebrum, liver, lung, kidney, and spinal cords were removed and conducted histologocal observation with H-E staining. In the histologocal observation of thigh muscle, cell infiltration, inflammatory, degeneration, necrosis of muscle fiber, and fibrosis were found in both thigh tissue. And the changes were depend on the dose of Sweet BV. But another organs were not detected in any abnormalities. 7

  18. Assessment of the wetting behavior of three different root canal sealers on root canal dentin

    OpenAIRE

    Muralidhar Tummala; Veeramachaneni Chandrasekhar; A Shashi Rashmi; Kundabala, M; Vasudev Ballal

    2012-01-01

    Aim: The objective of the present study was to evaluate and compare the wetting behavior of three different root canal sealers on the root canal dentin surface treated with irrigants and their combination. Materials and Methods: Decoronation and apical third resections of 27 extracted single-rooted human mandibular premolars were done. The roots were then split longitudinally into two halves, and randomly assigned into three treatment groups (n=18). The root dentin surfaces in Group1, Gro...

  19. MR determination of neonatal spinal canal depth

    Energy Technology Data Exchange (ETDEWEB)

    Arthurs, Owen, E-mail: owenarthurs@uk2.net [Centre for Cardiovascular MR, Great Ormond Street Hospital for Children, London WC1N 3JH (United Kingdom); Thayyil, Sudhin, E-mail: s.thayyil@ucl.ac.uk [Academic Neonatology, Institute for Women' s Health, London WC1E 6AU (United Kingdom); Wade, Angie, E-mail: a.wade@ucl.ac.uk [Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London (United Kingdom); Chong, W.K., E-mail: Kling.Chong@gosh.nhs.uk [Paediatric Neuroradiology, Great Ormond Street Hospital for Children, London (United Kingdom); Sebire, Neil J., E-mail: Neil.Sebire@gosh.nhs.uk [Histopathology, Great Ormond Street Hospital for Children, London WC1E 6AU (United Kingdom); Taylor, Andrew M., E-mail: a.taylor76@ucl.ac.uk [Centre for Cardiovascular MR, Cardiorespiratory Unit, Great Ormond Street Hospital for Children and UCL Institute of Cardiovascular Science, London WC1E 6AU (United Kingdom)

    2012-08-15

    Objectives: Lumbar punctures (LPs) are frequently performed in neonates and often result in traumatic haemorrhagic taps. Knowledge of the distance from the skin to the middle of the spinal canal (mid-spinal canal depth - MSCD) may reduce the incidence of traumatic taps, but there is little data in extremely premature or low birth weight neonates. Here, we determined the spinal canal depth at post-mortem in perinatal deaths using magnetic resonance imaging (MRI). Patients and methods: Spinal canal depth was measured in 78 post-mortem foetuses and perinatal cases (mean gestation 26 weeks; mean weight 1.04 kg) at the L3/L4 inter-vertebral space at post-mortem MRI. Both anterior (ASCD) and posterior (PSCD) spinal canal depth were measured; MSCD was calculated and modelled against weight and gestational age. Results: ASCD and PSCD (mm) correlated significantly with weight and gestational age (all r > 0.8). A simple linear model MSCD (mm) = 3 Multiplication-Sign Weight (kg) + 5 was the best fit, identifying an SCD value within the correct range for 87.2% (68/78) (95% CI (78.0, 92.9%)) cases. Gestational age did not add significantly to the predictive value of the model. Conclusion: There is a significant correlation between MSCD and body weight at post-mortem MRI in foetuses and perinatal deaths. If this association holds in preterm neonates, use of the formula MSCD (mm) = 3 Multiplication-Sign Weight (kg) + 5 could result in fewer traumatic LPs in this population.

  20. Ecohydrological features of some contrasting mires in Tierra del Fuego, Argentina

    Directory of Open Access Journals (Sweden)

    A. Grootjans

    2010-01-01

    Full Text Available In November 2005, Tierra del Fuego (Argentina hosted the biennial conference and field excursion of the International Mire Conservation Group (IMCG. The group considered the vegetation, hydrology, peat stratigraphy and possible management options for about 20 mires which were visited during a seven-day excursion. We report here some field observations and measurements of electrical conductivity (EC25 in five mires which have been selected to encompass the most important ecohydrological features of the mires of Tierra del Fuego. Existing and new data on landscape topography and vegetation were combined in three-dimensional drawings. These drawings are actually conceptual models which could underpin further ecohydrological research, and proved to be very useful as a basis for discussions amongst conference participants about possible ecohydrological relationships. The mires that were studied developed under a wide range of climatic conditions and included fens and bogs. The bogs typically developed from lakes or fens and most are now dominated by Sphagnum magellanicum. This species forms large hummocks, and can invade weakly-buffered fens. Most of the mires were well preserved, but effects of human impact - such as road building and peat extraction - were also noticeable.

  1. Iridium, platinum and rhodium baseline concentration in lichens from Tierra del Fuego (South Patagonia, Argentina).

    Science.gov (United States)

    Pino, Anna; Alimonti, Alessandro; Conti, Marcelo Enrique; Bocca, Beatrice

    2010-10-01

    Lichen samples of Usnea barbata were used as possible biomonitors of the atmospheric background level of iridium (Ir), platinum (Pt) and rhodium (Rh) in the remote region of Tierra del Fuego (South Patagonia, Argentina). Lichens were collected in 2006 at 53 sites covering 7 different areas of the region (24 transplanted lichens of the northern region and 29 native lichen samples of the central-southern region). A microwave acidic digestion procedure was used to mineralize the samples and a sector field inductively coupled plasma mass spectrometry method was developed to quantify the elements. The study of the influence of interferences on analyte signals and a quality control procedure were carried out. The analytical protocol was further applied to evaluate Ir, Pt and Rh bioaccumulation in lichens. The detection limits obtained were 0.010 ng g⁻¹, 0.013 ng g⁻¹ and 0.030 ng g⁻¹ for Ir, Pt and Rh, respectively. Recoveries at different fortification levels were between 96.3% and 106% and precision was 3.3% on average. The metals concentration (as dry weight) spanned the following ranges: Ir, Tierra del Fuego. Values detected are more likely influenced by the long-range atmospheric transport of these pollutants and, in comparison with densely populated areas in the world, they can represent the baseline for low impacted areas. PMID:20830409

  2. Isolation of Sphaerotilus-Leptothrix strains from iron bacteria communities in Tierra del Fuego wetlands.

    Science.gov (United States)

    Schmidt, Bertram; Sánchez, Leandro A; Fretschner, Till; Kreps, Gastón; Ferrero, Marcela A; Siñeriz, Faustino; Szewzyk, Ulrich

    2014-11-01

    Sheath-forming iron- and manganese-depositing bacteria belonging to the Sphaerotilus-Leptothrix group (SLG) are widespread in natural and artificial water systems. Known requirements for their growth include the presence of organic substrates and molecular oxygen. High concentrations of reduced iron or manganese, although not necessary for most species, make their growth a noticeable phenomenon. Such microbial communities have been studied mostly in the Northern Hemisphere. Here, we present descriptions of diverse ochre-depositing microbial communities in Tierra del Fuego, Argentina, using a combined approach of microscopical examination, clone library construction and cultivation focused on SLG bacteria. To date, only few SLG type strains are available. The present work increases the number and diversity of cultivated SLG bacteria by obtaining isolates from biofilms and sediment samples of wetlands in Tierra del Fuego. Thirty isolates were selected based on morphological features such as sheath formation and iron/manganese deposition. Five operational taxonomic units (OTUs) were deduced. Sequencing of 16S rRNA genes showed that one OTU is identical to the Leptothrix mobilis Feox-1(T) -sequence while the four remaining OTUs show similarity values related to previously described type strains. Similarity values ranged from 96.5% to 98.8%, indicating possible new species and subspecies. PMID:25098830

  3. para la valoración de tierras rurales en Guatemala

    Directory of Open Access Journals (Sweden)

    Mario Eddy Díaz Visquerra

    2014-01-01

    Full Text Available Se estima el valor de las tierras rurales del país con objeto de facilitar de forma objetiva los procesos de financiamiento de fincas, para el establecimiento de comunidades agrarias sostenibles. En esta investigación se analizaron mediante trabajo de campo 64 fincas en vías de mercado para estimar relaciones entre el precio por unidad de área y una serie de variables independientes tanto cuantitativas como cualitativas mediante análisis de regresión múltiple. Con significancia del 5% se concluye que las variables que ejercen mayor efecto sobre el valor de las tierras rurales son: la región natural donde están ubicadas las fincas.el área.la distancia a la cabecera departamental y la infraestructura vial de acceso (con o sin asfalto. Se determinaron modelos estadísticos de tipo logarítmico de la forma:LN (Precio·ha -1 = β 0 + β 1 LN (área+ β 2 LN (distancia cabecera departamental.

  4. Toxicity of 90Sr inhaled in a relatively insoluble form by beagle dogs

    International Nuclear Information System (INIS)

    Beagle dogs were exposed by inhalation to 90Sr in a relatively insoluble form to study long-term health effects. Lung burdens ranged from 0.12 to 96 μCi of 90Sr per kilogram of body weight. High levels of exposure have caused pulmonary fibrosis and radiation pneumonitis; lower level exposures caused long-term effects which included cancer of the lung, heart and tracheobronchial lymph nodes. Most of these tumors were hemangiosarcomas. Six dogs died during the past year and two of them had hemangiosarcoma primary to a tracheobronchial lymph node. This was a new finding in this study and indicates the importance of considering the radiation dose to thoracic lymph nodes which continually accumulate radioactive particles after inhalation exposure to relatively insoluble radioactive aerosols

  5. Toxicity of 90Sr inhaled in a relatively insoluble form by Beagle dogs. XIII

    International Nuclear Information System (INIS)

    Beagle dogs were exposed by inhalation to 90Sr in a relatively insoluble form to study long-term health effects. Lung burdens ranged from 0.02 to 96 μCi of 90Sr per kilogram of body weight. High levels of exposure resulted in radiation pneumonitis and pulmonary fibrosis; lower level exposures caused long-term effects which included cancer of the lung, heart and tracheobronchial lymph nodes. Most of these tumors were hemangiosarcomas. Three control dogs and two 90Sr-exposed dogs died or were euthanized during the past year. One exposed dog died with hemangiosarcoma of the liver; the other exposed dog died with hemangiosarcoma of the tracheobronchial lymph nodes. One control dog died during routine anesthesia, one died with hepatocellular carcinoma and the third died with transitional cell carcinoma of the bladder

  6. Bioavailability of water-soluble CoQ10 in beagle dogs.

    Science.gov (United States)

    Prosek, Mirko; Butinar, Janos; Lukanc, Barbara; Fir, Maja Milivojevic; Milivojevic, Luka; Krizman, Mitja; Smidovnik, Andrej

    2008-08-01

    The bioavailability of a novel water-soluble inclusion complex of CoQ10, prepared in our laboratory was determined and compared with the bioavailability of commercially available oil-based form of CoQ10. Experimental work consisted of single dose comparative bioavailability study on seven beagle dogs, with a 14-day washout period between treatments. Identification and quantification of CoQ10 was done with HPLC-MS method using positive APCI ionization and SIM mode, M+ m/z 863.4. The bioavailability results confirm that the water-soluble formulation has nearly three times higher AUC(0-48 h), two times higher Cmax, and Tmax is shortened from 6 to 4 h. PMID:18495407

  7. Clearance patterns for 111In-oxide particles deposited in specific airways of beagle dogs

    International Nuclear Information System (INIS)

    The International Commission on Radiological Protection (ICRP) has incorporated long-term retention of radioactive particles in conducting airways into its newly approved respiratory tract dosimetry model. This model is purported to provide a better basis for assessing risk associated with human inhalation exposures to radioactive particles. However, applying the new model requires an understanding of particle retention patterns in conducting airways of the lung. Studies are being conducted at ITRI to quantify long-term retention patterns for particles deposited at specific sites in conducting airways of Beagle dogs. The dog was selected as a model because long-term retention and clearance patterns for particles deposited in the lungs of dogs and humans are similar

  8. Biomarkers and heavy metal bioaccumulation in mussels transplanted to coastal waters of the Beagle Channel.

    Science.gov (United States)

    Giarratano, Erica; Duarte, Claudia A; Amin, Oscar A

    2010-03-01

    Mussels coming from a mussel farm at Brown Bay (Beagle Channel) were transplanted to four sites inside Ushuaia Bay for 2 and 4 weeks. The objective of this study was to assess the quality of coastal waters of Ushuaia Bay by measuring catalase activity, lipid peroxidation, total lipid content, bioaccumulation of heavy metals and condition index in transplanted mussel Mytilus edulis chilensis. Biomarkers except condition index showed significant differences among exposure times as well as among tissues. Digestive gland presented the highest catalase activity, malondialdehyde level and total lipid content. Digestive gland also was the main target tissue of accumulation of iron and copper, while gill accumulated the highest levels of zinc. A principal component analyzes with the whole set of data allowed to separate stations based on physicochemical conditions and biochemical responses of each studied area. PMID:19913913

  9. Seasonal and pollution-induced variations in biomarkers of transplanted mussels within the Beagle Channel.

    Science.gov (United States)

    Giarratano, Erica; Gil, Mónica N; Malanga, Gabriela

    2011-06-01

    The occurrence of biomarker variations linked to environmental factors makes it difficult to distinguish the effect of pollution. In an attempt to evaluate spatial and seasonal effects of environmental parameters on biomarker responses, mussels Mytilus edulis chilensis coming from an aquaculture farm were transplanted to several points within Ushuaia Bay (Beagle Channel) for 6 weeks in summer and winter. Activities of superoxide dismutase, catalase, glutathione-S-transferase and levels of lipid peroxidation were measured in gills and digestive gland. Cu, Zn, Fe, Cd and Pb concentrations were also assessed. Results indicated a significant effect of seasons on biological responses as well as in metal bioaccumulation showing the influence of natural factors such as dissolved oxygen, temperature and food availability. The interdependence of those environmental factors is important for the homeostasis of thermoconformers, especially regarding their oxidative metabolism and should also be taken into consideration to distinguish natural from pollution-induced variations. PMID:21550069

  10. Radium-226-induced bone lesions in beagle dogs treated by amputation: clinical, radiological, and histologic observations

    International Nuclear Information System (INIS)

    Within a colony of beagle dogs that had received intravenous injections of 226Ra there was a subgroup of dogs, each of which developed a painful lesion of a long bone. These bone lesions had their inception in bizarre, progressively expansile resorption cavities in which the process of normal bone tissue replacement was defective. On occasion, bone sarcomas arose in some of the sites of perturbed bone repair. This radiation-induced disturbance of the normal bone remodeling process with its preneoplastic spectrum of radiographic and histologic lesions was termed radiation-osteodystrophy. Lesions were studied by sequential radiography prior to the onset of clinical signs. Because of the painful nature of the lesion and difficulty experienced by the dogs in walking, full leg amputations were performed. This not only provided relief from clinical signs, but also permitted the dog to continue to live, allowing study of subsequently identified radiation-induced lesions

  11. Toxicity of 144Ce inhaled in a relatively insoluble form by immature Beagle dogs. XVII

    International Nuclear Information System (INIS)

    Immature Beagle dogs (3-mo old) received a single, brief inhalation exposure to 144Ce in fused aluminosilicate particles as part of a series of studies designed to study the effects of age on dose response relationships for inhaled radionuclides. Forty-nine dogs inhaled graded levels of 144Ce that resulted in initial lung burdens ranging from 0.004-140 μCi/kg 0.15-5200 kBq/kg) body weight. Five control dogs inhaled nonradioactive fused aluminosilicate particles. Forty-one of the 144Ce-exposed dogs have died: 11 with lung tumors 4 with tumors of the tracheobronchial lymph nodes, with a nasal cavity tumor, and 9 with non neoplastic diseases of the respiratory tract. Observations are continuing on the 8 144Ce-exposed dogs that are surviving at this time. (author)

  12. Flora bucal en perros de la raza Beagle con enfermedad periodontal inducida

    Directory of Open Access Journals (Sweden)

    Cabrera García, Alexei

    2012-01-01

    Full Text Available ResumenLa enfermedad periodontal afecta a los perros durante toda su vida y se debe a la acumulación de placa dental bacteriana en las coronas dentales a lo largo de la encía, lo que conlleva a una reacción inflamatoria de la misma, conocida como gingivitis. Con el fin determinar la flora bucal en perros con enfermedad periodontal inducida se estudiaron 10 canes de la raza Beagle que previamente fueron sometidos a una intervención quirúrgica para inducir la enfermedad.SummaryPeriodontal diseases affect the dogs all its life and this is due to the accumulation of bacterial dental plaque along the gums as results this provokes a well known inflammatory reaction defined as gingivitis. The purpose of this paper was to determine the bucal flora in dogs with periodontal disease induced.

  13. Lifetime tumor risk coefficients for beagle dogs that inhaled cerium-144 chloride

    Energy Technology Data Exchange (ETDEWEB)

    Boecker, B.B.; Hahn, F.F.; Griffith, W.C. [and others

    1995-12-01

    Reported here is one of the life-span radionuclide toxicology studies being conducted at ITRI in Beagle dogs. These studies are examining the life-span health risks of inhaled {Beta}-, {gamma}- and {alpha}-emitting radionuclides to expand available knowledge on these risks especially for the many cases for which human data are not available. The outcomes of these studies are providing important information on dosimetry and dose-response relationships for these inhaled radionuclides and the relative importance of a broad range of dose- and effect-modifying factors. A number of these studies are currently coming to completion. Much of the ITRI effort is being directed to final reviews of the dosimetric, clinical, and pathologic results and writing summary manuscripts. Radiation doses and effects in tissues adjacent to bone, specifically those of epithelial or marrow origin, should be considered when determining risks from internally deposited, bone-seeking radionuclides such as {sup 144}Ce.

  14. Biological effects of cesium-137 injected in beagle dogs of different ages

    Energy Technology Data Exchange (ETDEWEB)

    Nikula, K.J.; Muggenburg, B.A.; Griffith, W.C. [and others

    1995-12-01

    The toxicity of cesium-137 ({sup 137}Cs) in the Beagle dog was investigated at the Argonne National Laboratory (ANL) as part of a program to evaluate the biological effects of internally deposited radionuclides. The toxicity and health effects of {sup 137}Cs are important to understand because {sup 137}Cs is produced in large amounts in light-water nuclear reactors. Large quantities of cesium radioisotopes have entered the human food chain as a result of atmospheric nuclear weapons test, and additional cesium radioisotopes were released during the Chernobyl accident. Although the final analyses are not complete, three findings are significant: older dogs dies significantly earlier than juvenile and young adult dogs; greater occurrence of sarcomas in the cesium-137 injected dogs; the major nonneoplastic effect in dogs surviving beyond 52 d appears to be testicular atrophy.

  15. Toxicity of 239PuO2 in immature Beagle dogs. X

    International Nuclear Information System (INIS)

    Immature beagles have been exposed by inhalation to a monodisperse aerosol of 239PuO2 (1.5 μm AMAD) to compare the biological effects with those being observed in dogs exposed to a similar aerosol when they were young or aged adults. The study includes 96 dogs exposed to 239PuO2 and 12 controls. A total of 66 experimental and 11 control dogs are still alive. Six dogs died during the past year, all of radiation-related causes. Five dogs died from lung carcinomas and the sixth dog died of pneumonia/fibrosis, but with a lung tumor. With the large number of dogs still alive in this study, it is still premature to compare the cancer dose-response relationships for the immature and adult dogs. (author)

  16. Pyovagina and stump pyometra in a neutered XX sex-reversed Beagle: a case report

    International Nuclear Information System (INIS)

    An 18-month-old, neutered male beagle presented with acute abdominal signs and a suppurative infection of the urogenital tract. Chromosomal sex was female (78, XX), gonadal sex was male (testicles), and phenotypic sex was ambiguous, with evidence of both male and female duct systems. The internal and external genitalia consisted of epididymides, an underdeveloped uterus with an immature spermatic cord, communication between the uterus or cranial vagina and the membranous urethra, a urethrographically male urethra, a hypoplastic os penis, and a hypoplastic penis with hypospadia. Based on these findings and the familial history of a similarly affected litter mate, the dog was diagnosed as having the XX male syndrome with pyovagina and uterine stump pyometra. Radiographic and ultrasonographic investigations are described, and abnormalities of chromosomal sex, gonadal sex, and phenotypic sex are discussed

  17. Toxicity of inhaled 239PuO2 in immature beagle dogs

    International Nuclear Information System (INIS)

    Immature beagle dogs have been exposed by inhalation to a 1.5 μm aerodynamic diameter monodisperse aerosol of 239PuO2 to compare the biological effects with those seen in young adult and aged dogs exposed to a similar aerosol. To date, 18 dogs have been exposed to the aerosol, resulting in graded initial lung burdens ranging from 0.003 to 0.38 μCi/kg body weight. Two dogs have been exposed to the aerosol diluent and serve as controls. Two of the 18 exposed animals were sacrificed 8 days after exposure to provide information on initial deposition and distribution. All other exposed animals are alive 400 days after exposure. No dogs were exposed during the past year because of an outbreak of canine parvovirus enteritis which caused death in 8 to 10 week-old dogs

  18. Toxicity of 90Sr inhaled in a relatively insoluble form by Beagle dogs. XIV

    International Nuclear Information System (INIS)

    Beagle dogs were exposed by inhalation to 90Sr in a relatively insoluble form to study long-term health effects. Lung burdens ranged from 0.12 to 96 μCi of 90Sr/kg body weight. High levels of exposure resulted in radiation pneumonitis and pulmonary fibrosis; lower level exposures caused long-term effects, including cancer of the lung, heart, and tracheobronchial lymph modes. Most of these tumors were hemangiosarcomas. Two control dogs and two 90Sr-exposed dogs died or were euthanized during the past year. One exposed dog died with hemangiosarcoma of the spleen; the other exposed dog died with pulmonary thrombosis. One control dog died of pulmonary carcinoma, and the other control dog died of a carcinoma of the bladder. The remaining 19 exposed and 11 control dogs are being maintained for lifetime observation

  19. Expression of Kirsten murine sarcoma virus sequences in Beagle dog tissues

    International Nuclear Information System (INIS)

    Labeled cDNA synthesized from RNA extracted from 238PuO2-, 239PuO2-, and 90Sr-induced lung tumors in Beagle dogs, from nontumor tissue from 239PuO2-exposed dogs, and from unexposed dog lung and liver tissue produces strong hybridization signals with a plasmid (pKSma) that contains Kirsten murine sarcoma virus (KMSV) sequences. At least 90 percent of the KMSV sequences are expressed in these dog tissues, including sequences corresponding to p21 K-ras, qp70 envelope glycoprotein, and at least one other proviral sequence. The expression of Kirsten ras and other sarcoma virus sequences may have important implications for the interpretation of carcinogenesis studies in these dogs. (author)

  20. Toxicity of 91Y inhaled in a relatively insoluble form by Beagle dogs. XVI

    International Nuclear Information System (INIS)

    Beagle dogs were exposed by inhalation to aerosols of 91Y in fused aluminosilicate particles, resulting in initial lung burdens ranging from 11 to 360 μCi (0.4-13 MBq) 91Y/kg body weight. These 96 dogs, plus 12 controls, were maintained for life-span observation of toxic and carcinogenic effects. Dogs with the highest lung burdens died at early times with radiation pneumonitis. At later times, tumors were seen in lungs, nasal cavity, heart, and tracheobronchial lymph nodes; these organs received the highest radiation doses. Observations are continuing on the 5 exposed and 3 control dogs that remain alive 5120 to 5605 days after exposure. 2 figures, 1 table

  1. Toxicity of 239PuO2 inhaled by aged Beagle dogs. X

    International Nuclear Information System (INIS)

    The influence of age at exposure on the metabolism, dosimetry, and biological effects of inhaled 239PuO2 particles is being studied in aged Beagle dogs (8.0-10.5 yr of age at exposure). Forty-eight dogs inhaled 239PuO2 particles with an activity median aerodynamic diameter of 1.5 mm to achieve graded levels of initial pulmonary burdens (IPB) ranging from 0.02-0.66 μCi 239Pu/kg body weight (0.75-24 kBq/kg). Twelve other dogs were exposed to the aerosol diluent only. All forty-eight exposed dogs have died, including two in the past year. The twelve control dogs have also died, including one in the past year. Radiation pneumonitis and pulmonary fibrosis have been the primary causes of death in these aged dogs exposed to 239PuO2. (author)

  2. Comparison of the rheological properties of four root canal sealers

    Institute of Scientific and Technical Information of China (English)

    Seok Woo Chang; Kwang Shik Bae; Young-Kyu Lee; Qiang Zhu; Won Jun Shon; Woo Cheol Lee; Kee Yeon Kum; Seung Ho Baek; In Bog Lee; Bum-Soon Lim

    2015-01-01

    The flowability of a root canal sealer is clinically important because it improves the penetration of the sealer into the complex root canal system. The purpose of this study was to compare the flowabilities of four root canal sealers, measured using the simple press method (ISO 6876), and their viscosities, measured using a strain-controlled rheometer. A newly developed, calcium phosphate-based root canal sealer (Capseal) and three commercial root canal sealers (AH Plus, Sealapex and Pulp Canal Sealer EWT) were used in this study. The flowabilities of the four root canal sealers were measured using the simple press method (n55) and their viscosities were measured using a strain-controlled rheometer (n55). The correlation between these two values was statistically analysed using Spearman’s correlation test. The flow diameters and the viscosities of the root canal sealers were strongly negatively correlated (r520.8618). The viscosity of Pulp Canal Sealer EWT was the lowest and increased in the following order:AH Plus,Sealapex,Capseal (P,0.05). All of the tested root canal sealers showed characteristic time-and temperature-dependent changes in their rheological properties. The viscosities measured using the strain-controlled rheometer were more precise than the flowabilities measured using the simple press method, suggesting that the rheometer can accurately measure the rheological properties of root canal sealers.

  3. Comparative toxicity of strontium-90 and radium-226 in beagle dogs

    International Nuclear Information System (INIS)

    We are completing a 30-year study of the biological effects of 90Sr and 226Ra in the beagle in order to predict the possible long-term hazards to people from chronic exposure to low levels of irradiation. Animals received either radionuclide by several means of administration: (a) continual ingestion of 90Sr, (b) a single intravenous injection of 90Sr, or (c) a series of eight intravenous injections of 226Ra. Although administration of 90Sr and 226Ra ended at 540 days of age, the animals continued to receive chronic, low-level radiation doses from these bone-seeking radionuclides throughout life. This project is the largest single cohort study in beagles of internally deposited radionuclides. It is unique in use of the ingestion route for 90Sr and in exposure that began before birth and continued throughout development to adulthood with uniform labeling of the skeletons with 90Sr. The last of the dogs died in 1986 at age 18.5 years, but we are continuing to investigate the significance of these long-term exposures given at low dose rates with regard to cancer production, physiologic well-being, and shortening of life through the detailed records that were kept and by study of preserved materials. All the data have been successfully accumulated and entered into a main-frame computer data base management system. Current work is exclusively directed at preparing research papers summarizing the results and the associated biostatistical and survival analyses. 15 refs., 1 fig., 4 tabs

  4. Study on Plasma Concentration and Bioavailability of Wogonin in Beagle's Dogs

    Institute of Scientific and Technical Information of China (English)

    LI Jian-chun; CHEN Fei-hu; DONG Hai-jun; GAO Shu

    2011-01-01

    Objective To develop an LC-MS/MS method for determining the concentration of wogonin in dog plasma and investigate the pharmacokinetics and bioavailability by different administrations of wogonin in Beagle's dogs. Methods LC-MS/MS was employed in determining the concentration of wogonin with the selected ion monitoring model after liquid-liquid extraction with ethyl acetate of dog plasma samples. The lower limit of quantification was 0.105 μg/L. Target ions were at m/z 285.0→270.0 for wogonin and 373.3→305.3 for finasteride. In a randomized, self-control, and cross-over study, six male Beagle's dogs were treated with different administration methods in three test periods. Pharmacokinetic parameters were calculated with DAS software (Ver. 2.0). Results The calibration curve was linear in the range of 0.105-107.36 μg/L for wogonin in dog plasma samples. The main pharmacokinetic parameters of ig administration (native drug of 15 mg/kg and solution preparation of 5 mg/kg) and iv route were as follows: Cmax (2.5 ± 1.1), (7.9 ± 3.3), and (6838.7 ± 1322.1) μg/L, tmax (0.7 ± 0.3) and (0.3 ± 0.2) h for the both former, AUC0-1 (7.1 ± 2.0), (21.0 ± 3.2), and (629.7 ±111.8) μg·h/L. The absolute bioavailability of native and solution of wogonin were (0.59 ± 0.35)% and (3.65 ± 2.00)%, respectively. Conclusion The validated method is convenient, sensitive, and specific, and the improvement of wogonin solubility could remarkably increase the absolute bioavailability.

  5. Toxicity of inhaled 90Sr in fused aluminosilicate particles in beagle dogs. VIII

    International Nuclear Information System (INIS)

    Studies on the metabolism, dosimetry and biological effects of 90Sr inhaled in a relatively insoluble form by Beagle dogs have continued during the past year to define the biological consequences of inhaling this important radionuclide in a form which has a long retention time in the lung. One hundred and six dogs were exposed to a polydisperse aerosol of fused aluminosilicate particles labeled with 90Sr. Initial lung burdens ranged from 0.21 to 94 μCi 90Sr per kilogram of body weight (μCi/kg). Eighteen control dogs were exposed to an aerosol of stable strontium in fused aluminosilicate particles. These 124 dogs were assigned to the longevity study. An additional 26 dogs were exposed similarly to achieve lung burdens of approximately 1.5 to 12 μCi/kg and assigned for sacrifice at intervals after exposure to define metabolism and dosimetry of this aerosol in Beagle dogs. Of the longevity dogs, 33 dogs having initial lung burdens of 16 to 94 μCi 90Sr/kg and cumulative doses to lung of 40,000 to 96,000 rads have died from radiation pneumonitis and/or pulmonary fibrosis from 159 to 2373 days after exposure. Thirty-one dogs with initial lung burdens of 3.7 to 36 μCi 90Sr/kg and cumulative doses to lung of 13,000 to 68,000 rads have died from hemangiosarcomas in the lung or heart between 644 and 2565 days after exposure. In addition, one dog developed a bronchioloalveolar carcinoma, another developed epidermoid carcinoma of the lung, another died of pneumonia while recovering from anesthesia, one dog died at 1821 days after exposure with a hemangiosarcoma of the spleen and two dogs developed squamous cell carcinomas in the nasal cavity. The remaining exposed dogs and controls of the longevity study are surviving at 1022 to 2803 days after exposure

  6. Osteoporotic-like effects of cadmium on bone mineral density and content in aged ovariectomized beagles

    Energy Technology Data Exchange (ETDEWEB)

    Sacco-Gibson, N.; Abrams, J.; Chaudhry, S.; Hurst, D.; Peterson, D.; Bhattacharyya, M.

    1992-12-31

    Our purpose was to evaluate the effects of ovariectomy in conjunction with cadmium (Cd) exposure on bone. Aged female beagles with {sup 45}Ca-labeled skeletons ovariectomized and exposed to Cd. Successive vertebral scans by dual photon absorptiometry monitored changes in bone mineral density (BMD) in each dog with time. Results showed that ovariectomy or Cd exposure alone caused significant decreases in BMD; ovariectomy with Cd exposure caused the greatest decrease. Ovariectomy alone did not decrease BMD in the distal end or mid-shaft of the tibia while BMD of the distal tibia decreased significantly due to Cd exposure alone. Combination treatment resulted in significant decreases in BMD of both tibial regions. At necropsy, tibiae, humeri, lumbar vertebrae and ribs were obtained for biochemical analysis. No group-to-group differences in bone weights (wet, dry, ash), in ash/dry ratios, or in long bone and vertebral Ca/dry or Ca/ash ratios were observed. Significantly higher total {sup 45}Ca content and {sup 45}Ca/dry and {sup 45}Ca/ash ratios were observed in long bones and vertebrae of OV- and OV+ groups. In contrast, intact ribs showed significantly decreased Ca/dry and Ca/ash ratios compared to the SO-group. Quartered ribs demonstrated regional responses to specific treatment; decreases in total Ca content were greatest in the mid-rib region ({minus}36 to {minus}46%). Results suggest that in the aged female beagle, bone mineral loss associated with estrogen depletion is not only related to bone type (trabecular versus cortical) but also to bone Ca pools. Our results also suggest that a regional heterogeneity of bone plays a role in responsiveness to ovariectomy and Cd exposure. These aspects suggest that Cd is an exogenous factor affecting bone mineral loss independently of estrogen depletion. However, estrogen depletion primes bone for responsiveness to Cd-induced bone mineral loss.

  7. Osteoporotic-like effects of cadmium on bone mineral density and content in aged ovariectomized beagles

    International Nuclear Information System (INIS)

    Our purpose was to evaluate the effects of ovariectomy in conjunction with cadmium (Cd) exposure on bone. Aged female beagles with 45Ca-labeled skeletons ovariectomized and exposed to Cd. Successive vertebral scans by dual photon absorptiometry monitored changes in bone mineral density (BMD) in each dog with time. Results showed that ovariectomy or Cd exposure alone caused significant decreases in BMD; ovariectomy with Cd exposure caused the greatest decrease. Ovariectomy alone did not decrease BMD in the distal end or mid-shaft of the tibia while BMD of the distal tibia decreased significantly due to Cd exposure alone. Combination treatment resulted in significant decreases in BMD of both tibial regions. At necropsy, tibiae, humeri, lumbar vertebrae and ribs were obtained for biochemical analysis. No group-to-group differences in bone weights (wet, dry, ash), in ash/dry ratios, or in long bone and vertebral Ca/dry or Ca/ash ratios were observed. Significantly higher total 45Ca content and 45Ca/dry and 45Ca/ash ratios were observed in long bones and vertebrae of OV- and OV+ groups. In contrast, intact ribs showed significantly decreased Ca/dry and Ca/ash ratios compared to the SO-group. Quartered ribs demonstrated regional responses to specific treatment; decreases in total Ca content were greatest in the mid-rib region (-36 to -46%). Results suggest that in the aged female beagle, bone mineral loss associated with estrogen depletion is not only related to bone type (trabecular versus cortical) but also to bone Ca pools. Our results also suggest that a regional heterogeneity of bone plays a role in responsiveness to ovariectomy and Cd exposure. These aspects suggest that Cd is an exogenous factor affecting bone mineral loss independently of estrogen depletion. However, estrogen depletion primes bone for responsiveness to Cd-induced bone mineral loss

  8. Relationship of dose rate and total dose to responses of continuously irradiated beagles

    International Nuclear Information System (INIS)

    Young-adult beagles were exposed continuously (22 hours/day) to 60Co γ rays in a specially constructed facility. The exposure rates were either 5, 10, 17, or 35 R/day, and the exposures were terminated at either 600, 1400, 2000, or 4000 R. A total of 354 dogs were irradiated; 221 are still alive as long-term survivors, some after more than 2000 days. The data on survival of these dogs, coupled with data from similar preliminary experiments, allow an estimate of the LD50 for γ-ray exposures given at a number of exposure rates. They also allow comparison of the relative importance of dose rate and total dose, and the interaction of these two variables, in the early and late effects after protracted irradiation. The LD50 for the beagle increases from 258 rad delivered at 15 R/minute to approximately 3000 rad at 10 R/day. Over this entire range, the LD50 is dependent upon hematopoietic damage. At 5 R/day and less, no meaningful LD50 can be determined; there is nearly normal continued hematopoietic function, survival is prolonged, and the dogs manifest varied individual responses in other organ systems. Although the experiment is not complete, interim data allow several important conclusions. Terminated exposures, while not as effective as radiation continued until death, can produce myelogenous leukemia at the same exposure rate, 10 R/day. More importantly, at the same total accumulated dose, lower exposure rates are more damaging than higher rates on the basis of the rate and degree of hematological recovery that occurs after termination of irradiation. Thus, the rate of hematologic depression, the nadir of the depression, and the rate of recovery are dependent upon exposure rate; the latter is inversely related and the former two are directly related to exposure rate

  9. Radiation-Induced Neoplasms in Beagles after Administrations of 90Sr and 226Ra

    International Nuclear Information System (INIS)

    The comparative carcinogenic efficiency of two bone-seeking radionuclides is under study in a colony of several hundred beagles. The toxicity of internally deposited alpha emitters (226Ra and its daughters) and of beta irradiation (90Sr) at comparable dosage rates indicates marked differences in site of appearance and mode of action in litters studied up to 7 years of age. Radiation carcinogenesis in beagles exposed to 90Sr daily from midgestation to adulthood (1.5 yr) is at present confined to dogs fed 4 μCi 90Sr/d or higher. The 20 cases constitute a spectrum of myeloproliferative disorders characterized by terminal anaemias, and ranging from myeloid metaplasia to granulocytic leukaemia. Continuous high-level 90Sr irradiation to bone and marrow from early life onward causes a thickened hypocellular bone ('pachyostosis'), some instances of myelofibrosis, and persistent mild leukopenia on which the final spectrum of terminal disoideis is superimposed. In contrast, up to 100 μCl 226Ra given intravenously (8 equally spaced injections at 14 to 18 months of age) to young adults is not a potent marrow cell carcinogen. The higher LET, shorter-range alpha particles are efficient in inducing bone cancers (14 cases) and skeletal lesions similar to those documented in watch-dial luminizers exposed to 226Ra in the early 1900's. The incidence of haematopoietic and skeletal neoplasms observed is dose-rate related, and the morphologic characteristics have several analogues in human cancer. The use of identically treated litters rather than individuals affords additional opportunity to study possible familial factors in the distribution of the neoplasms. Pathogenic evaluation at this juncture strongly indicates that continued bone and marrow irradiation in early life is more likely to induce haematopoietic neoplasms than is skeletal irradiation starting in young adulthood, which induces osseous neoplasms. (author)

  10. Effects of a tetracycline blended polylactic and polyglycolic acid membrane on the healing of one-wall intrabony defects in beagle dogs

    International Nuclear Information System (INIS)

    The purpose of this study was to evaluate the regenerative effects of a tetracycline blended polylactic and polyglycolic acid (TC-PLGA) and non-blended polylactic and polyglycolic acid (PLGA) barrier membrane on one-wall intrabony defects in beagle dogs. It can be concluded that when used for guided tissue regeneration TC-PLGA membranes show a beneficial effect on one-wall intrabony defects in beagle dogs

  11. Gross and surgical pathologic findings in beagles receiving gamma radiation during development and sacrificed at 5 or 8 years of age

    International Nuclear Information System (INIS)

    Gross necropsy examinations have been completed on each of the 140 beagles scheduled for sacrifice at 5 years of age and on 28 of 140 beagles for sacrifice at 8 years of age. To date, the only major gross pathologic changes that are correlated with radiation treatment are an unusual number of testicular tumors occurring in irradiated dogs, especially in those receiving 100R at 55 days postcoitus and sacrificed at 5 years of age

  12. Effects of a tetracycline blended polylactic and polyglycolic acid membrane on the healing of one-wall intrabony defects in beagle dogs

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Il-Young [Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-752l (Korea, Republic of); Jung, Ui-Won [Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-752l (Korea, Republic of); Kim, Chang-Sung [Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-752l (Korea, Republic of); Lee, Yong-Keun [Department and Research Institute of Dental Biomaterials and Bioengineering, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-750 (Korea, Republic of); Cho, Kyoo-Sung [Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-752l (Korea, Republic of); Chai, Jung-Kiu [Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-752l (Korea, Republic of); Kim, Chong-Kwan [Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-752l (Korea, Republic of); Choi, Seong-Ho [Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 134 Shinchon-Dong, Seodaemun-gu, Seoul 120-752l (Korea, Republic of)

    2007-09-15

    The purpose of this study was to evaluate the regenerative effects of a tetracycline blended polylactic and polyglycolic acid (TC-PLGA) and non-blended polylactic and polyglycolic acid (PLGA) barrier membrane on one-wall intrabony defects in beagle dogs. It can be concluded that when used for guided tissue regeneration TC-PLGA membranes show a beneficial effect on one-wall intrabony defects in beagle dogs.

  13. Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine

    OpenAIRE

    Araujo, Joseph A.; Landsberg, Gary M.; Milgram, Norton W.; Miolo, Alda

    2008-01-01

    Aged dogs demonstrate cognitive decline that is linked to brain aging. The purpose of the present study was to examine if a commercially available nutraceutical supplement that may be neuroprotective and contains phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine could improve cognitive function in aged beagles. Nine aged beagles were tested on performance on a delayed-non-matching-to-position task, which is a neuropsychological test of short-term visuospatial memory. All subjects w...

  14. Fechados radiocarbónicos en una turbera holocénica del centro de Tierra del Fuego

    OpenAIRE

    Trivi de Mandri, Matilde; D'Antoni, Héctor Luis; Burry, Susana

    2005-01-01

    El objetivo de esta nota es presentar nueve fechados radiocarbónicos de una turbera situada en el centro de la Isla Grande de Tierra del Fuego. Se señala la importancia que tienen estos sistemas como registros paleoambientales en su relación con los estudios arqueológicos.

  15. Acaparamiento de tierras y acumulación global capitalista: aspectos clave en América Latina.

    Directory of Open Access Journals (Sweden)

    Natalia Landivar

    2014-03-01

    Full Text Available El número especial de la Canadian  Journal  of Develop-ment Studies aporta con nuevos elementos para entender el fenómeno del acaparamiento de tierras. Basado en estudios empíricos de expertos de siete países de AméricaLatina.

  16. Ley 19.640, Sub Régimen de promoción industrial en la Isla Grande de Tierra del Fuego

    OpenAIRE

    Bergues, Sebastían

    2014-01-01

    Asesoramiento para la toma de decisiones de fabricar en Tierra del Fuego en base al decreto 459/10 "Plan Conectar Igualdad", para las empresas Newsan SA y Novatec Solutions SA. Problema: Analizar y evaluar la conveniencia de fabricar netbooks conforme al "Plan Conectar Igualdad" en la Isla Grande de Tierra del Fuego. Justificación: La provincia de Tierra del Fuego, Antártida e Islas del Atlántico Sur es la provincia más joven y nueva de las veintitrés provincias que conforman la R...

  17. Historia y memoria campesina: silencios y representaciones sobre la lucha por la tierra y la represión en Ongoy

    OpenAIRE

    Guido Chati

    2015-01-01

    Este artículo sostiene que hay espacios sociales en Perú donde se producen memorias alternativas sobre la violencia política que tuvo lugar entre 1980 y 2000. En Andahuaylas, Apurímac, las narrativas recurrentes hablan acerca de la servidumbre en la hacienda, de la movilización campesina por la restitución de sus tierras, la ocupación de tierras y sobre su violenta represión. Existe esta memoria victoriosa respecto de la ocupación de la tierra, al lado de una memoria de victimización respecto...

  18. Water quality of the Boca Raton canal system and effects of the Hillsboro Canal inflow, southeastern Florida, 1990-91

    Science.gov (United States)

    McKenzie, D.J.

    1995-01-01

    The City of Boca Raton in southeastern Palm Beach County, Florida, is an urban residential area that has sustained a constant population growth with subsequent increase in water use. The Boca Raton network of canals is controlled to provide for drainage of excess water, to maintain proper coastal ground-water levels to prevent saltwater intrusion, and to recharge the surficial aquifer system from which the city withdraws potable water. Most of the water supplied to the Boca Raton canal system and the surficial aquifer system, other than rainfall and runoff, is pumped from the Hillsboro Canal. The Biscayne aquifer, principal hydrogeologic unit of the surficial aquifer system, is highly permeable and there is a close relation between water levels in the canals and the aquifer. The amount of water supplied by seepage from the conservation areas is unknown. Because the Hillsboro Canal flows from Lake Okeechobee and Water Conservation Areas 1 and 2, which are places of more highly mineralized ground water and surface water, the canal is a possible source of contamination. Water samples were collected at 10 canal sites during wet and dry seasons and analyzed for major inorganic ions and related characteristics, nutrients, and trace elements. All concentrations were generally within or less than the drinking-water standards established by the Florida Department of Environmental Protection. The high concentrations of sodium and chloride that were detected in samples from the Boca Raton canal system are probably from the more mineralized water of the Hillsboro Canal. Other water-quality data, gathered from various sources from 1982 through 1991, did not indicate any significant changes nor trends. The effects of the Hillsboro Canal on the water quality of the Boca Raton canal system are indicated by increased concentrations of sodium, chloride, dissolved solids, and total organic carbon. Concentrations of the constituents in the canal water generally decrease with distance

  19. Atmospheric background trace elements deposition in Tierra del Fuego region (Patagonia, Argentina), using transplanted Usnea barbata lichens.

    Science.gov (United States)

    Conti, Marcelo Enrique; Finoia, Maria Grazia; Bocca, Beatrice; Mele, Giustino; Alimonti, Alessandro; Pino, Anna

    2012-01-01

    Lichen, Usnea barbata, transplants taken from Tierra del Fuego (south Patagonia, Argentina) were tested as potential biomonitors of atmospheric airborne deposition in an apparently pristine environment. In 2005, lichens were sampled in a reference site (n = 31) and transplanted in the northern Region of Tierra del Fuego. After, respectively, 1 month and 1 year of exposure, we collected them. The aim of the study was to determine the bioaccumulation of 26 elements in order to evaluate the background levels in the selected area. Samples were analyzed by the sector field inductively coupled plasma mass spectrometry. Discriminant analysis on principal component analysis factors was applied in order to explore the relationship among the different elements as far as time and spatial variation in transplants regards. The analysis was tested by Monte Carlo test based on 999 replicates. The most important contamination source resulted to be the atmospheric soil particle deposition. Furthermore, the results were compared with those obtained from the lichens collected in central and southern Tierra del Fuego. This study confirms the ability of U. barbata to reflect the background levels of the 26 elements in that environment. Compared with other background sites in the world, we did confirm that Tierra del Fuego lichens have a low content of the studied elements. Tierra del Fuego turned out not to be a pristine environment as supposed, but it can be considered as a reference basal ecosystem for useful comparisons among different geographical areas. These findings can be very relevant and useful for environmental conservation programs. PMID:21409357

  20. Anal cancer; Cancer du canal anal

    Energy Technology Data Exchange (ETDEWEB)

    Fesneau, M.; Champeaux-Orange, E. [Service de radiotherapie, Centre regional universitaire de cancerologie Henry-S.-Kaplan CHU de Tours, Hopital Bretonneau, 37 - Tours (France); Champeaux-Orange, E. [Service d' oncologie-radiotherapie, Centre hospitalier regional d' Orleans, 45 - Orleans (France); Hennequin, C. [Service de cancerologie-radiotherapie, hopital Saint-Louis, 75 - Paris (France)

    2010-07-01

    Anal canal epidermoid carcinomas represent 1.2% of digestive cancers and 6% of ano-rectal cancers. For localized diseases, the treatment is based on radiotherapy with or without chemotherapy (5-FU and cisplatin or mitomycin), according to tumour and nodal extension. The recommended treatment dose is 45 Gy in the anal canal, the mesorectum, para-rectal lymph nodes, and inguinal lymph nodes. An additional dose of 15 to 20 Gy is delivered in the initial tumour for good responders. Salvage surgery is necessary in case of poor response. The organs at risk to be considered are bladder, femur heads, small intestine and vulva. The objective of this work is to summarize the epidemiological and radio-anatomic and prognostic characteristics of this tumour. The conformal radiotherapy technique is illustrated by a case report. (authors)

  1. Ewing Sarcoma of the External Ear Canal.

    Science.gov (United States)

    Binnetoglu, Adem; Baglam, Tekin; Tokuc, Gulnur; Kecelioglu Binnetoglu, Kiymet; Gerin, Fatma; Sari, Murat

    2016-01-01

    Background. Ewing sarcoma (ES) is a high-grade malignant tumor that has skeletal and extraskeletal forms and consists of small round cells. In the head and neck region, reported localization of extraskeletal ES includes the larynx, thyroid gland, submandibular gland, nasal fossa, pharynx, skin, and parotid gland, but not the external ear canal. Methods. We present the unique case of a 2-year-old boy with extraskeletal ES arising from the external ear canal, mimicking auricular hematoma. Results. Surgery was performed and a VAC/IE (vincristine, adriamycin, cyclophosphamide alternating with ifosfamide, and etoposide) regimen was used for adjuvant chemotherapy for 12 months. Conclusion. The clinician should consider extraskeletal ES when diagnosing tumors localized in the head and neck region because it may be manifested by a nonspecific clinical picture mimicking common otorhinolaryngologic disorders. PMID:27313930

  2. Squamous cell carcinoma of the anal canal.

    LENUS (Irish Health Repository)

    Martin, F T

    2012-01-31

    Squamous cell carcinoma ofthe anal canal represents 1.5% of all malignancies affectingthe gastrointestinal tract. Over the past 20 years dramatic changes have been seen in both the epidemiological distribution of the disease and in the therapeutic modalities utilised to manage it. CLINICAL MANAGEMENT: Historically abdominoperineal resection had been the treatment of choice with local resection reserved for early stage disease. Work by Nigro et al. has revolutionised how we currently manage carcinoma of the anal canal, demonstrating combined modality chemoradiotherapy as an appropriate alternative to surgical resection with the benefit of preserving sphincter function. Surgery is then reserved for recurrent disease with salvage abdominoperineal resection. This article reviews current literature and highlights the changing therapeutic modalities with selected clinical cases

  3. The shape of the human lumbar vertebral canal A forma do canal vertebral lombar humano

    Directory of Open Access Journals (Sweden)

    Edmundo Zarzur

    1996-09-01

    Full Text Available Literature on the anatomy of the human vertebral column characterizes the shape of the lumbar vertebral canal as triangular. The purpose of the present study was to determine the precise shape of the lumbar vertebral canal. Ten lumbar vertebral columns of adult male cadavers were dissected. Two transverse sections were performed in the third lumbar vertebra. One section was performed at the level of the lower border of the ligamenta flava, and the other section was performed at the level of the pedicles. The shape of the lumbar vertebral canal at the level of the pedicles tends to be oval or circular, whereas the shape of the lumbar vertebral canal at the level of the lower border of the ligamenta flava is triangular. Thus, the shape of the human lumbar vertebral canal is not exclusively triangular, as reported in the literature. It is related to the level of the transversal section performed on the lumbar vertebra. This finding should be taken into consideration among factors involved in the spread of solutions introduced into the epidural space.A literatura sobre a anatomia da coluna vertebral descreve como sendo triangular o formato do canal vertebral na região lombar. O objetivo deste estudo é determinar a real forma do canal da coluna vertebral lombar.Dez colunas vertebrais de cadáveres de homens adultos foram dissecadas. Dois cortes transversais foram executados na terceira vértebra lombar. Um corte foi feito no nível das bordas inferiores de dois ligamentos amarelos vizinhos e o outro corte foi transversal, no nível dos pedículos. A forma do canal vertebral variou: no nível dos pedículos ela tende a ser oval ou circular e junto às bordas inferiores dos ligamentos amarelos passa a ser triangular. Portanto, a forma do canal vertebral lombar não é somente triangular; ela depende do nível em que se faz o corte transversal da vértebra. Estes achados devem ser levados em consideração entre os fatores envolvidos na difusão das

  4. Comparison of Bacterial Leakage between 3 Different Root Canal Obturation Techniques in Oval Shaped Canals

    Directory of Open Access Journals (Sweden)

    Eshagh-ali Saberi

    2014-06-01

    Full Text Available Introduction: The purpose of this study was to evaluate the sealing ability of 3 obturation techniques in oval-shaped canals by bacterial leakage assessment. Methods: Sixty mandibular incisors with oval canals were selected after providing buccolingual and mesiodistal radiographs. The teeth were sectioned at a 10 mm distance from the apex. After instrumentation, the teeth were divided into 3 groups and the canals in the three groups were obturated with lateral condensation (G1, warm vertical condensation (G2 and thermoplasticized injectable gutta percha (G3. The teeth were exposed to human saliva. Observing the turbidity of the BHI broth for a period of 63 days the number of days required for the complete contamination of root canals was recorded. The data were analyzed using descriptive statistical methods and Kruskal-Wallis test with SPSS statistical software. Results: Warm vertical condensation (G2 needed a significantly greater average time for leakage than the two other methods. No significant differences were found between lateral condensations and thermoplasticized injectable G.P techniques. Conclusion: warm vertical condensation provides a better seal against bacterial leakage than lateral condensation and obtura II method in obturating oval-canals.

  5. Spinal canal narrowing during simulated frontal impact

    OpenAIRE

    Ivancic, Paul C.; Panjabi, Manohar M.; Tominaga, Yasuhiro; Pearson, Adam M.; Elena Gimenez, S.; Maak, Travis G.

    2005-01-01

    Between 23 and 70% of occupants involved in frontal impacts sustain cervical spine injuries, many with neurological involvement. It has been hypothesized that cervical spinal cord compression and injury may explain the variable neurological profile described by frontal impact victims. The goals of the present study, using a biofidelic whole cervical spine model with muscle force replication, were to quantify canal pinch diameter (CPD) narrowing during frontal impact and to evaluate the potent...

  6. Koebner phenomenon of the ear canal skin.

    LENUS (Irish Health Repository)

    Young, O

    2009-02-01

    The Koebner phenomenon originally described the appearance of psoriatic lesions in the uninvolved skin of patients with psoriasis as a consequence of trauma. We describe a case of concurrent lichen planus and sarcoidosis in the auditory canal, which represents an unusual manifestation of the Koebner phenomenon. This is the first case of concurrent lichen planus and sarcoidosis in the head and neck region and highlights the need for biopsy to allow accurate histopathological diagnosis and treatment.

  7. Koebner phenomenon of the ear canal skin.

    LENUS (Irish Health Repository)

    Young, O

    2012-02-01

    The Koebner phenomenon originally described the appearance of psoriatic lesions in the uninvolved skin of patients with psoriasis as a consequence of trauma. We describe a case of concurrent lichen planus and sarcoidosis in the auditory canal, which represents an unusual manifestation of the Koebner phenomenon. This is the first case of concurrent lichen planus and sarcoidosis in the head and neck region and highlights the need for biopsy to allow accurate histopathological diagnosis and treatment.

  8. CSF Hydrodynamics in the spinal canal

    Czech Academy of Sciences Publication Activity Database

    Kaczmarská, A.; Vaněk, P.; Maršík, František; Převorovská, Světlana; Otáhal, S.; Otáhal, J.

    Brno : Brno University of Technology, 2006 - (Burša, J.; Fuis, V.), s. 116-117 ISBN 80-214-3232-2. [Human Biomechanics 2006. Hrotovice (CZ), 13.11.2006-16.11.2006] R&D Projects: GA ČR(CZ) GA106/03/0958 Institutional research plan: CEZ:AV0Z20760514 Keywords : spinal canal * cerebrospinal flluid * hydrodynamics Subject RIV: BK - Fluid Dynamics

  9. Root canal cleaning through cavitation and microstreaming

    OpenAIRE

    Verhaagen, B.

    2012-01-01

    We have investigated the flow from a needle using Computational Fluid Dynamics simulations and high-speed imaging experiments on sub-millimeter fluidic channels. These have shown that the flow is not effective in delivering the bleach near the bacteria, due to the complex geometry of the root canal. Laser-Activated Irrigation (LAI) and Passive Ultrasonic Irrigation (PUI) are techniques for improving the irrigant distribution, of which we have investigated the cleaning mechanism, being acousti...

  10. Epidermoid carcinoma of the external auditory canal

    International Nuclear Information System (INIS)

    A 43 years-old, urban, male patient assists the consultation of Otolaryngology with a long evolving otorrhea (around two years), receiving several treatments against the external otitis he suffered. With those antecedents and what we found when examining him, we decided to take a sample (biopsy) of the area, diagnosing an epidermoid carcinoma of the left external canal, an infrequent pathology in our settings

  11. Root canal filling using Resilon: a review.

    LENUS (Irish Health Repository)

    Shanahan, D J

    2011-07-01

    Root canal treatment is achieved by chemo-mechanical debridement of the root canal system followed by filling. The filling material \\'entombs\\' residual bacteria and acts as a barrier which prevents the entrance of oral microorganisms and reinfection of the root canal system through microleakage. However, filling with contemporary root filling materials such as gutta-percha offers limited long-term resistance to microorganisms; as a result other materials such as Resilon have been investigated as alternatives. The aim of this review was to analyse the literature to consider whether Resilon is a suitable root canal filling material. A MEDLINE and Cochrane library search including various keyword searches identified several papers which investigated or discussed Resilon or RealSeal\\/Epiphany. Analysis of the literature demonstrated that the bulk of the literature is in vitro in nature, based largely on leakage-type studies, and demonstrates a wide variety of methodologies with conflicting findings; as a result meaningful conclusions are difficult. Within the limit of these in vitro studies Resilon appears to perform adequately in comparison to gutta-percha, however, as a result of the questionable merit of such studies, it cannot presently be considered an evidence-based alternative to the current gold standard gutta-percha. It is imperative that before Resilon is considered as a replacement material, a better understanding of the physical properties of the resin sealer and the reality of the adhesive \\'monoblock\\' are elucidated. The literature also demonstrates a paucity of quality long-term clinical outcome studies which will need to be addressed before firm conclusions can be reached.

  12. Ad libitum feeding following ovariectomy in female Beagle dogs: effect on maintenance energy requirement and on blood metabolites.

    Science.gov (United States)

    Jeusette, I; Detilleux, J; Cuvelier, C; Istasse, L; Diez, M

    2004-04-01

    The aim of this study was (i) to evaluate the effect of ovariectomy on daily energy requirement in Beagle dogs, and (ii) to evaluate the effects of ad libitum feeding with a high energy diet on energy consumption, body weight gain and blood metabolites in these spayed dogs. Four young adult female Beagle dogs were used. Ovariectomy induced a significant decrease of daily energy requirement in dogs. Ad libitum feeding, initiated 6 months after spaying, induced a significant increase in consumption in spayed dogs. This overconsumption was greatest during the first month of ad libitum feeding but continued for the entire 4 months of this period. When fed ad libitum, dogs gained excess body weight without significant effect on plasma cholesterol, triglycerides, glucose and insulin, at short term. These data suggest that energy intake should be strictly controlled to avoid excess weight gain in spayed dogs. PMID:15059235

  13. Experimental therapeutic effect of combined cytokines on beagle dogs exposed to 4.5 Gy γ-rays

    International Nuclear Information System (INIS)

    Objective: To evaluate the effects of combined administration of recombinant human interleukin-11 (rhIL-11), recombinant human G-CSF (rhG-CSF) and recombinant human interleukin-2 (rhIL-2) on acute radiation sickness (ARS) beagles. Methods: Sixteen beagle were irradiated with 4.5 Gy 60Co γ-rays to establish ARS models, and were divided into irradiation control group, supportive care group and combined cytokines treatment group. After irradiation irradiation control group was given no treatment, the dogs in supportive care group received purely symptomatic treatment, while combined cytokines treatment group received rhIL-11 50 μg/(kg·d) subcutaneously (0-14 d) and rhIL-2 1 x 106 U/d(29-43 d) besides symptomatic treatment. Manifestation and characteristics of ARS (authors)

  14. Endoscopic posterior decompression of lumbar canal stenosis

    Directory of Open Access Journals (Sweden)

    Yad Ram Yadav

    2013-01-01

    Full Text Available Lumbar canal stenosis (LCS is quite common. Surgery is indicated when patient fails to improve after conservative treatment. Endoscopic technique can be used in LCS and lateral recess stenosis. It can be performed in degenerative canal stenosis or with disc bulges. Bilateral severe bony canal stenosis and unstable spine are the contraindications. This procedure should be avoided in patients with a history of trauma. Detailed history and thorough physical examination should be performed to find out exact level of pathology responsible for symptoms. Patient′s symptoms must correlate with radiological findings. Magnetic resonance imaging is the investigation of choice because of its superior visualization of soft-tissue. Computed tomography scan does give a more accurate and detailed picture of the bony anatomy. Although the operative time and the complication rate could be more in the initial learning curve, the results of endoscopic decompression are comparable with conventional open procedures with the additional benefit of decreased complications and lower morbidity, when sufficient experience is gained. Complications in endoscopic surgery for LCS could be dural tears, hematomas and root and facet injury. This procedure is also associated with limitations such as steep learning curve and the contra lateral decompression may not be as good as ipsilateral side. Some of the limitations of this technique can be overcome by attending live operative workshop, practice on models and hands on cadaveric dissection. Conversion to an open procedure may be required when there is disorientation, management of dural tear and for control of bleeding.

  15. Revestimientos y acabados superficiales en construcciones con tierra contemporáneas

    Directory of Open Access Journals (Sweden)

    Castilla, F. J.

    2011-09-01

    Full Text Available Earth construction is in increasing demand in some areas of building activity, which means a need for technical solutions to maintain and preserve the properties of earth walls. Like earth wall construction techniques themselves, materials used for rendering (plastering, painting, panelling, etc have evolved in a way that allows us to find formal solutions suitable for every architectural situation. This paper deals with the special features of each rendering technique available in contemporary construction, from renderings permitting earth wall textures and finish to be appreciated, to plasters from different materials. Special attention will be focused on clay plasters, which are more appreciated due to its natural characteristics and compatibility with the base wall. The explanations are supported by different examples of buildings where these techniques have been used during the last two decades.

    La creciente demanda para la construcción de muros de tierra en algunos ámbitos del sector de la edificación conlleva la necesidad de plantear soluciones constructivas que permitan el adecuado mantenimiento de las prestaciones de dichos muros. Al igual que las propias técnicas para la construcción de los muros, los materiales utilizados para su revestimiento y protección han evolucionado permitiendo una gran variedad de soluciones formales acordes a cada situación. En este artículo se pretende hacer una revisión sobre las particularidades de las diferentes posibilidades que se presentan en el panorama de la construcción actual: desde los revestimientos que permitan mantener a la vista los acabados de los muros de tierra a los revocos de distinta naturaleza, con especial incidencia en aquellos que utilizan la propia tierra como material base, siendo los más apropiados a priori por su natural compatibilidad con el soporte. La explicación se acompañará de ejemplos ilustrativos de la aplicación de dichas técnicas en edificios

  16. La tierra en armas de Dávalos-Serrano (o las armas del teatro

    Directory of Open Access Journals (Sweden)

    Marcela Beatriz Sosa

    2003-01-01

    Full Text Available La tierra en armas (1926 constituye un texto enigmático por diversas cuestiones, a pesar de su celebridad –es la obra teatral más famosa de la literatura salteña- y de su aparente transparencia al representar hechos históricos relativos a la gesta de Güemes. El primer enigma es el problema de la autoría, ya que La tierra en armas surge de la escritura en colaboración de Juan Carlos Dávalos y Ramón Serrano, pero en el momento de publicación del texto (1935 aparecerá en la portada sólo el nombre de Dávalos. El gesto editorial de borrar el nombre del segundo autor en esa primera publicación es decisivo para el futuro teatral de Serrano, quien desaparece posteriormente de la escena salteña. La segunda cuestión deriva de la categoría de teatro histórico a la cual pertenece La tierra en armas La ficcionalización de un personaje histórico implica plantear las complejas relaciones que se establecen entre discurso dramático y discurso histórico. Luego de trazar someramente la trayectoria épica de Güemes, se realiza una descripción de la acción dramática y de los fundamentales procedimientos discursivos, como el encadenamiento entre la intriga principal (histórica y la secundaria (sentimental, la mise en abyme de la leyenda de la flor del Ilolay y la visualización escénica del texto. La tercera cuestión incluye el contexto de producción, circulación y recepción del teatro de la época, así como el nivel ideológico, sin los cuales sería imposible postular una interpretación del texto de Dávalos y Serrano como estrategia individual y colectiva de afianzamiento de la identidad.

  17. Dynamics of Alloplastic Bone Grafts on an Early Stage of Corticotomy-Facilitated Orthodontic Tooth Movement in Beagle Dogs

    OpenAIRE

    Hyung-Joo Choi; Dong-Yeol Lee; Tae-Woo Kim

    2014-01-01

    Alveolar augmented corticotomy is effective in accelerating orthodontic tooth movement, but the effect only lasts for a relatively short time. Therefore, the purpose of this study was to investigate the underlying biology of the immediate periodontal response to orthodontic tooth movement after a corticotomy with alloplastic bone grafts. The results demonstrated that measurable tooth movement began as early as 3 days after the intervention in beagle dogs. Based on the results and histological...

  18. Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs

    OpenAIRE

    LIU, HUI; Wang, Ya-Jing; YANG, Lei; Zhou, Mei; Jin, Man-Wen; Xiao, Guo-Sheng; Wang, Yan; Sun, Hai-Ying; Li, Gui-Rong

    2016-01-01

    We previously reported that duodenal administration of the natural flavone acacetin can effectively prevent the induction of experimental atrial fibrillation (AF) in canines; however, it may not be used intravenously to terminate AF due to its poor water-solubility. The present study was to design a water-soluble prodrug of acacetin and investigate its anti-AF effect in beagle dogs. Acacetin prodrug was synthesized by a three-step procedure. Aqueous solubility, bioconversion and anti-AF effic...

  19. Safety and biodistribution of a double-deleted oncolytic vaccinia virus encoding CD40 ligand in laboratory Beagles

    OpenAIRE

    Autio, Karoliina; Knuuttila, Anna; Kipar, Anja; Pesonen, Sari; Guse, Kilian; Parviainen, Suvi; Rajamäki, Minna; Laitinen-Vapaavuori, Outi; Vähä-Koskela, Markus; Kanerva, Anna; Hemminki, Akseli

    2014-01-01

    We evaluated adverse events, biodistribution and shedding of oncolytic vaccinia virus encoding CD40 ligand in two Beagles, in preparation for a phase 1 trial in canine cancer patients. Dog 1 received one dose of vaccinia virus and was euthanized 24 hours afterwards, while dog 2 received virus four times once weekly and was euthanized 7 days after that. Dogs were monitored for adverse events and underwent a detailed postmortem examination. Blood, saliva, urine, feces, and organs were collected...

  20. Effect of Age and Level of Cognitive Function on Spontaneous and Exploratory Behaviors in the Beagle Dog

    OpenAIRE

    Siwak, Christina T.; Tapp, P. Dwight; Milgram, Norton W.

    2001-01-01

    Cognitively characterized young and aged beagle dogs were administered six different spontaneous behavior tests, which provided measures of locomotion, exploration, and social interaction. Consistent with our previous findings, we obtained no overall effect of age on locomotion. We did find, however, that for the aged dogs locomotion correlated with level of cognitive function, being lowest in age-unimpaired dogs and highest in impaired dogs. Exploratory behavior, as measured by response to n...

  1. Use of linear model analysis techniques in the evaluation of radiation effects on the life span of the beagle

    International Nuclear Information System (INIS)

    The dependency of the beagle-dog life span on level of and age at exposure to 60Co gamma radiation was analyzed by several techniques; one of these methods was linear model analysis. Beagles of both sexes were given single, bilateral exposures at 8, 28, or 55 days postcoitus (dpc) or at 2, 70, or 365 days postpartum (dpp). Dogs exposed at 8, 28, or 55 dpc or at 2 dpp received 0, 20, or 100 R, whereas those exposed at 70 or 365 dpp received 0 or 100 R. Beagles were designated initially either as sacrifice or as life-span animals. All deaths of life-span study animals were classified as spontaneous, hence for this group the mean age of death was a quantitative response that can be analyzed by linear model analysis techniques. Such analyses for each age group were performed, taking into account differences due to sex, linear and quadratic dependency on dose, and interaction between sex and dose. At this time most of the animals have reached 11 years of age. No significant effects of radiation on mean life span have been detected. 6 refs., 3 figs., 3 tabs

  2. Absorbed dose distribution patterns in the beagle thorax after inhalation of 90Sr--90Y fused clay particles. II

    International Nuclear Information System (INIS)

    This experiment was designed to examine absorbed dose patterns in the Beagle dog thorax after inhalation of polydisperse fused montmorillonite clay particles labeled with 90Sr-90Y. Sixteen dogs were exposed nose-only to achieve initial lung burdens of 91 to 200 μCi. Dogs are being serially sacrificed and photographic data and autoradiographic data produced for a series of parallel planes approximately 1 cm apart through the thorax. Data analysis will include definition of absorbed dose patterns in the Beagle thorax at 8 days, 64 days, 1 year, 2 years, and 3 years post-exposure. To date, 8-day, 64-day, and 1-year animals have been sacrificed and partially analyzed. The result of this experiment will be a better understanding of deposition and absorbed dose patterns and allow a better correlation between absorbed dose and biological response for Beagle dogs exposed to relatively insoluble aerosols contaminated by energetic beta-emitting radionuclides. In addition, results will allow quantitating anomalies in deposition patterns, such as the striated pattern near ribs previously observed in this laboratory. (U.S.)

  3. EVOLUCIÓN DEL CLIMA A TRAVÉS DE LA HISTORIA DE LA TIERRA

    OpenAIRE

    Norma Sánchez-Santillán; Rubén Sánchez-Trejo; Guadalupe de la Lanza Espino; René Garduño

    2014-01-01

    Naturalmente, la atmósfera y, por tanto, el clima evolucionaron junto con el continente, el océano, el interior de la Tierra y todos los demás componentes planetarios. Esta co-evolución frecuentemente fue a través de catástrofes, por cierto fructíferas, especialmente para la evolución y diversificación biológi - cas. En varias etapas, el vulcanismo aportó ingredientes a la atmósfera, otro tanto llegó con los cometas y meteoritos; el océano contribuyó con vapor de agua con sus sucesivos cambio...

  4. Atmospheric electric discharges and grounding systems; Descargas atmosfericas y sistemas de conexion a tierra

    Energy Technology Data Exchange (ETDEWEB)

    Rivas, Elena [ed.] [Instituto de Investigaciones Electricas, Temixco, Morelos (Mexico)

    1999-07-01

    In this article the work made by the Institute of Investigaciones Electricas (IIE), in the area of atmospheric electric discharges and grounding connections at Comision Federal de Electricidad (CFE) is presented. The work consisted of the revision of the procedures for the design of transmission lines and substations of CFE from which high indexes of interruptions are reported, from this, a program was defined that allowed to improve the existing designs in CFE. [Spanish] En este articulo se presenta el trabajo realizado por el Instituto de Investigaciones Electricas (IIE), en el area de descargas atmosfericas y conexiones a tierra en Comision Federal de Electricidad (CFE). El trabajo consistio en la revision de los procedimientos de diseno de las areas de transmision y subestaciones de la CFE para los que se reportan altos indices de salidas, a partir de esto se definio un programa que permitio mejorar los disenos existentes en la CFE.

  5. Clasificación probabilistica de umbrales de lluvia para predecir deslizamientos de tierra

    OpenAIRE

    Medina-Cetina, Zenon; Cepeda, Rivera Jose Mauricio

    2012-01-01

    Este artículo presenta la formulación probabilista de un modelo empírico para la determinación de deslizamientos de tierra producidos por el efecto de lluvia. El modelo de umbral propuesto I contiene un vector de parámetros, el cual integra el efecto de la intensidad de la lluvia I y su duración D. La clasificación probabilista de este modelo está basada en la solución del problema inverso definido por el marco teórico Bayesiano. Esta aproximación permite la identificación, caracterización y ...

  6. Crecimiento de Colossoma macropomum en estanques de tierra en dependencia de la densidad.

    Directory of Open Access Journals (Sweden)

    Jorge Günther

    2016-03-01

    Full Text Available Se analiza el crecimiento y la utilización de alimento del tambaquí, Colossoma macropomum, cultivado a densidades de 0,5, 1 y 2 peces/m2 en estanques de tierra de 60m2 con alimento balanceado con 35% proteína. No se encontraron diferencias estadísticas significativas con respecto a la densidad. Sin embargo, el crecimiento obtenido fue mucho menor que en otro ensayo realizado en las mismas condiciones y simultáneamente en un estanque de 3000 m2, por lo que se discute la hipótesis de que el crecimiento del tambaquí esté relacionado con el tamaño del estanque.

  7. Substations grounding systems design; Diseno de sistemas de conexion a tierra en subestaciones

    Energy Technology Data Exchange (ETDEWEB)

    Velazquez Sanchez, Raul [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1986-12-31

    The grounding systems have been the object of a great number of analytical and experimental studies in the past 15 years, that have given rise to research reports on the several aspects involved in this technique. In this work are briefly reviewed various aspects that is necessary to take into account for its design, analysis and put in operation. [Espanol] Los sistemas de conexion a tierra han sido objeto de gran cantidad de estudios analiticos y experimentales en los pasados quince anos, que han dado origen a informes de investigacion sobre los diversos aspectos que involucra esta tecnica. En este trabajo se revisan brevemente diversos aspectos que es necesario considerar para su diseno, analisis y puesta en operacion.

  8. La tierra entre derecho y cultura indígena en Argentina

    Directory of Open Access Journals (Sweden)

    Marzia Rosti

    2009-03-01

    Full Text Available The paper considers the relationships between the indigenous peoples and the Argentinian State since the XIX century until 1994, when it was introduced in the Constitution the provision acknowledging to the indigenous peoples “la posesión y propiedad comunitarias de las tierras que tradicionalmente ocupan”, “la entrega de otras aptas y suficientes para el desarrollo humano” and granting them “la parcipación en la gestión referida a sus recursos naturales y a los demás intereses que los afecten” (art. 75, inc. 17. The paper describes then the issue concerning the claim for indigenous land – raised by the new constitutional provision – and focuses on some significant cases and the more recent jurisprudence on that issue.

  9. Saprolegnia oliviae sp. nov. isolated from an Argentine river (Tierra del Fuego Province, Argentina).

    Science.gov (United States)

    Steciow, Mónica Mirta

    2003-02-28

    Saprolegnia oliviae sp. nov. is described from litter (floating dead twigs, leaves and roots) in the Olivia River, Ushuaia Department, Tierra del Fuego Province (Argentina). The new species is illustrated and compared with other species of the genus. Distinguishing characteristics of S. oliviae are the production of smooth oogonia (with some lateral or terminal projections) and the absence of antheridial branches on the majority of the oogonia, but when present, they are mostly diclinous, at times oogonia are supplied with androgynous and monoclinous antheridial branches. The oogonial stalks are predominantly short and straight or long and bent, curved or many times coiled; oospores are distinctive subcentric, (1-) 15-50 (-70) per oogonium. Morphological details of the new species and its comparison with other described species are discussed here. PMID:12620629

  10. Problemas ambientales detectados por la población de Ushuaia (Tierra del Fuego, Argentina

    Directory of Open Access Journals (Sweden)

    María Gabriela Orzanco

    1999-01-01

    Full Text Available Ushuaia, capital de la provincia de Tierra del Fuego. es una ciudad que ha experimentado un crecimiento poblacional intenso en un ambiente con restricciones físicas y biológicas, por lo que se han manifestado numerosos problemas ambientales. Este trabajo pretende conocer la imagen que de la ciudad tienen los habitantes de sus diferentes zonas. Se elaboró un cuestionario que se distribuyó en siete zonas de la ciudad. A partir de 114 cuestionarios completos recogidos se puede concluir que la imagen de la ciudad construida a partir de sus problemas generales y ambientales, y de los recursos a preservar, difiere de acuerdo con la zona, existiendo en general una relación entre el tipo de problemas percibidos y el nivel educativo y el grupo ocupacional predominante en la misma.

  11. NARRATOLOGÍA EN LA NOVELA HÍBRIDA NO SERÁ LA TIERRA DE JORGE VOLPI

    Directory of Open Access Journals (Sweden)

    Roberto Ángel G.

    2013-07-01

    Full Text Available El presente texto efectúa un estudio narratológico de la novela de Jorge Volpi No será la Tierra. Se analiza la estructura contradictoria del libro, la multiplicidad de tramas, el narrador polifónico, el tiempo posapocalíptico, el espacio antiutópico y desencantado y los personajes, coprotagonistas del siglo XX. Todas estas características antes mencionadas contribuyen, en el ámbito de la desterritorialización, a desalojar posturas que tienden a anquilosarse en conceptos fijos y sin movimiento, por lo que los distintos rasgos narratológicos en las novelas híbridas --aquellas que están compuestas por una yuxtaposición de subgéneros-- siempre estarán emparentados con las nociones de heterogeneidad, diversidad y pluralidad, en el marco de la caída de los grandes relatos del siglo XX.

  12. Three new species and one new record of Tullbergiidae (Collembola: Onychiuroidea) from Tierra del Fuego.

    Science.gov (United States)

    Arbea, Javier I

    2016-01-01

    Three new species, Tullbergia rapoporti sp. nov., Dinaphorura nerudai sp. nov. and Dinaphorura najtae sp. nov., and one new record, Tullbergia meridionalis Cassagnau & Rapoport, 1962 are described based on specimens from Tierra del Fuego. Tullbergia rapoporti sp. nov. is similar to T. crozetensis, but can be distinguished from it by the presence of an empodial appendage and the chaetotaxy of Abd VI. Dinaphorura nerudai sp. nov. is diagnosed by the dorsal pso formula, the seven spiniform processes on Abd VI, an elongate PAO, the absence of vesicle on Ant IV and the dorsal chaetotaxy. Dinaphorura najtae sp. nov. is characterised by the dorsal pso formula, the seven spiniform processes on Abd VI, a triangular PAO, the absence of vesicle on Ant IV and the dorsal chaetotaxy. PMID:27394481

  13. Advances in extended reach drilling technology allow development of new marginal reservoirs offshore Tierra del Fuego

    Energy Technology Data Exchange (ETDEWEB)

    Delahaye, Thierry; Naegel, Matthieu [Total Austral S.A., Buenos Aires (Argentina)

    1998-07-01

    The paper presents the latest development by Total Austral of marginal satellites of the Hidra field made possible by extended reach drilling technology. Lying 6 km off the coast of Tierra del Fuego in 45 m of water, the Hidra field was originally developed in 1989-1990 with conventional deviated wells drilled from two small wellhead platforms, Hidra Centro and Hidra Norte. In 1996 a first series of three ERD wells were drilled with a jack-up from these platforms in order to tap the Ara Sur and Hidra Sur accumulations. Although many technical difficulties had to be overcome, the project was successfully completed, one of the wells (HNP-7) reaching an horizontal departure of 6.2 km at 1700 m TVD representing more than twice the reach of previous conventional wells. (author)

  14. Características y problemas de tenencia de la tierra en el sector agropecuario colombiano

    OpenAIRE

    Tobón Restrepo Arturo

    2012-01-01

    El término “Tenencia” es bastante amplio, pues relaciona la posesión física de un bien sin importar la legitimidad en el dominio de él. En cuanto a la posesión nuestro Código Civil (3) estipula: "La posesión es la tenencia de una cosa determinada con ánimo de señor o dueño, sea que el dueño o el que se la da por tal tenga la cosa por sí misma, o por otra persona que la tenga en lugar y a nombre de él". Para nuestro fin concretemos únicamente en el aspecto de la tierra. El presente...

  15. ROOT CANAL IRRIGANTS AND IRRIGATION TECHNIQUES: A REVIEW

    Directory of Open Access Journals (Sweden)

    Aniketh

    2015-04-01

    Full Text Available Root canal irrigation is not much emphasised in endodontic therapy. Most articles discussed are on root canal shaping and obturation not much emphasis is given for irrigation. There are many irrigation solutions which are introduced into market. The primary objective of root canal therapy is the ret ention of the pulpless or pulpally involved tooth with its associated periapical tissues in a healthy state. Achievement of this objective requires that the pulpal spaces and contents be eliminated as sources of infection. As the Enterococcus faecalis is a lso found to be the most important cause for endodontic failures, the action and efficacy of fewer irrigants against E. faecalis should also be given prime importance as of others. Therefore, the introduction of an antimicrobial endodontic irrigant during root canal therapy should be given priority in the hierarchy of root canal treatment. The purpose of this article is to analyse root canal irrigants, irrigation techniques and irrigation protocol.

  16. Bryophyte-cyanobacteria associations during primary succession in recently Deglaciated areas of Tierra del Fuego (Chile.

    Directory of Open Access Journals (Sweden)

    María Arróniz-Crespo

    Full Text Available Bryophyte establishment represents a positive feedback process that enhances soil development in newly exposed terrain. Further, biological nitrogen (N fixation by cyanobacteria in association with mosses can be an important supply of N to terrestrial ecosystems, however the role of these associations during post-glacial primary succession is not yet fully understood. Here, we analyzed chronosequences in front of two receding glaciers with contrasting climatic conditions (wetter vs drier at Cordillera Darwin (Tierra del Fuego and found that most mosses had the capacity to support an epiphytic flora of cyanobacteria and exhibited high rates of N2 fixation. Pioneer moss-cyanobacteria associations showed the highest N2 fixation rates (4.60 and 4.96 µg N g-1 bryo. d-1 very early after glacier retreat (4 and 7 years which may help accelerate soil development under wetter conditions. In drier climate, N2 fixation on bryophyte-cyanobacteria associations was also high (0.94 and 1.42 µg N g-1 bryo. d-1 but peaked at intermediate-aged sites (26 and 66 years. N2 fixation capacity on bryophytes was primarily driven by epiphytic cyanobacteria abundance rather than community composition. Most liverworts showed low colonization and N2 fixation rates, and mosses did not exhibit consistent differences across life forms and habitat (saxicolous vs terricolous. We also found a clear relationship between cyanobacteria genera and the stages of ecological succession, but no relationship was found with host species identity. Glacier forelands in Tierra del Fuego show fast rates of soil transformation which imply large quantities of N inputs. Our results highlight the potential contribution of bryophyte-cyanobacteria associations to N accumulation during post-glacial primary succession and further describe the factors that drive N2-fixation rates in post-glacial areas with very low N deposition.

  17. Bryophyte-cyanobacteria associations during primary succession in recently Deglaciated areas of Tierra del Fuego (Chile).

    Science.gov (United States)

    Arróniz-Crespo, María; Pérez-Ortega, Sergio; De Los Ríos, Asunción; Green, T G Allan; Ochoa-Hueso, Raúl; Casermeiro, Miguel Ángel; de la Cruz, María Teresa; Pintado, Ana; Palacios, David; Rozzi, Ricardo; Tysklind, Niklas; Sancho, Leopoldo G

    2014-01-01

    Bryophyte establishment represents a positive feedback process that enhances soil development in newly exposed terrain. Further, biological nitrogen (N) fixation by cyanobacteria in association with mosses can be an important supply of N to terrestrial ecosystems, however the role of these associations during post-glacial primary succession is not yet fully understood. Here, we analyzed chronosequences in front of two receding glaciers with contrasting climatic conditions (wetter vs drier) at Cordillera Darwin (Tierra del Fuego) and found that most mosses had the capacity to support an epiphytic flora of cyanobacteria and exhibited high rates of N2 fixation. Pioneer moss-cyanobacteria associations showed the highest N2 fixation rates (4.60 and 4.96 µg N g-1 bryo. d-1) very early after glacier retreat (4 and 7 years) which may help accelerate soil development under wetter conditions. In drier climate, N2 fixation on bryophyte-cyanobacteria associations was also high (0.94 and 1.42 µg N g-1 bryo. d-1) but peaked at intermediate-aged sites (26 and 66 years). N2 fixation capacity on bryophytes was primarily driven by epiphytic cyanobacteria abundance rather than community composition. Most liverworts showed low colonization and N2 fixation rates, and mosses did not exhibit consistent differences across life forms and habitat (saxicolous vs terricolous). We also found a clear relationship between cyanobacteria genera and the stages of ecological succession, but no relationship was found with host species identity. Glacier forelands in Tierra del Fuego show fast rates of soil transformation which imply large quantities of N inputs. Our results highlight the potential contribution of bryophyte-cyanobacteria associations to N accumulation during post-glacial primary succession and further describe the factors that drive N2-fixation rates in post-glacial areas with very low N deposition. PMID:24819926

  18. El antiguo cementerio de la mision de Río Grande, Tierra del Fuego

    Directory of Open Access Journals (Sweden)

    García Laborde, Pamela

    2010-01-01

    Full Text Available En el marco del proceso de contacto interétnico ocurrido hacia fines del siglo XIX y principios del XX en Tierra del Fuego, lo acontecido específicamente en la misión salesiana La Candelaria (Rio Grande cobra relevancia por la variedad de registros y fuentes que dicho escenario ofrece. La aproximación historiográfica permitió generar información acerca de la presencia de tuberculosis como causa principal de muerte entre los aborígenes que vivieron en la misión y sobre la dieta, la actividad física y las condiciones en las que vivieron aquellos. Paralelamente tres campañas de excavación realizadas hasta el momento permitieron exhumar restos óseos humanos de once individuos integrantes de la comunidad Selk'nam del cementerio de la misión. El objetivo de este trabajo es presentar los primeros resultados sobre el relevamiento de patologías nutricionales-metabólicas e infecciosas surgidos de los trabajos de campo realizados por todo el equipo de investigación en dicho cementerio. Los resultados hallados muestran hasta el momento una alta frecuencia de indicadores de stress metabólico-nutricional, mayor a la observada en general en restos de aborígenes de Tierra del Fuego en otros contextos arqueológicos. Además, se observaron lesiones infecciosas inespecíficas que también están presentes en frecuencias altas en casos de tuberculosis

  19. Primeros ensayos petrofísicos sobre la roca dimensional de Tierra del Fuego

    Directory of Open Access Journals (Sweden)

    Rogelio Daniel Acevedo

    2011-06-01

    Full Text Available Se muestran aquí los primeros ensayos de laboratorio sobre las rocas dimensionales de Tierra del Fuego, región que tenía una potencialidad no evaluada respecto al uso posible de este recurso nativo. Nunca habían sido empleadas hasta ahora rocas duras (ígneas ni pizarras en la construcción residencial, el revestimiento de fachadas ó pisos. Dos pequeñas canteras de rocas plutónicas han sido abiertas recientemente: una de ellas en el cerro Jeu-Jepén, aprovechada para la construcción de la escollera marina del puerto de Río Grande y la ruta nacional, y la otra en la península de Ushuaia, iniciada con el propósito de remover un morro para localizar el aeropuerto y usada últimamente como revestimiento de viviendas. Sobre un grupo de muestras fueguinas se realizaron para este trabajo ensayos físicos de densidad aparente, absorción de agua y porosidad abierta, como asimismo ensayos mecánicos de resistencia a la compresión y a la tensión, y también algunos ensayos Dorry para medir su resistencia a la abrasión. En la Isla Grande de Tierra del Fuego los tipos más apropiados como rocas ornamentales han resultado ser las distintas variedades de rocas granitoides, con relativamente altas resistencias a la compresión y a la tensión. Las rocas del cerro Jeu-Jepén analizadas reúnen entonces las mejores condiciones para su aprovechamiento inmediato: buenos resultados petrofísicos, posibilidad de obtención de bloques de tamaño adecuado, descubrimiento de la cantera y fácil acceso.

  20. Facial nerve canal dehiscence in chronic otitis media without cholesteatoma

    OpenAIRE

    Nomiya, Shigenobu; Kariya, Shin; Nomiya, Rie; MORITA, NORIMASA; Nishizaki, Kazunori; Paparella, Michael M.; Cureoglu, Sebahattin

    2013-01-01

    The information on incidence of the facial nerve canal dehiscence in chronic otitis media is important for surgeons. The purpose of this study is to disclose the histopathologic findings of facial nerve canal dehiscence in human temporal bones with chronic otitis media. We divided the human temporal bones into two groups (age 4 years, and under 4 years of age). We evaluated the incidence and the area of the facial nerve canal dehiscence in chronic otitis media under light microscopy. Age-matc...

  1. Ulnar Nerve Compression in Guyon's Canal by Ganglion Cyst

    OpenAIRE

    Kwak, Kyung-Woo; Kim, Min-Su; Chang, Chul-Hoon; Kim, Seong-Ho

    2011-01-01

    Compression of the ulnar nerve in Guyon's canal can result from repeated blunt trauma, fracture of the hamate's hook, and arterial thrombosis or aneurysm. In addition, conditions such as ganglia, rheumatoid arthritis and ulnar artery disease can rapidly compress the ulnar nerve in Guyon's canal. A ganglion cyst can acutely protrude or grow, which also might compress the ulnar nerve. So, clinicians should consider a ganglion cyst in Guyon's canal as a possible underlying cause of ulnar nerve c...

  2. Feasibility and limitations of endoscopy in Guyon's canal

    OpenAIRE

    Noszczyk, Bartłomiej H.; Zdybek, Piotr

    2014-01-01

    Introduction This retrospective report summarizes observations from eight operations where the endoscopically assisted approach was used to explore Guyon's canal syndromes of idiopathic aetiology. Aim To evaluate the feasibility and limitations of endoscopic Guyon's canal release performed from a distal forearm incision. Material and methods Eight charts and video records of eight ulnar tunnel syndrome patients presenting concomitant idiopathic Guyon's canal syndromes were retrospectively rev...

  3. Cervical spinal canal narrowing and cervical neurologi-cal injuries

    OpenAIRE

    Zhang, Ling; Chen, Hai-Bin; Wang, Yi; ZHANG Li-ying; Liu, Jing-cheng; WANG Zheng-guo

    2012-01-01

    【Abstract】Cervical spinal canal narrowing can lead to injury of the spinal cord and neurological symptoms in-cluding neck pain, headache, weakness and parasthesisas. According to previous and recent clinical researches, we investigated the geometric parameters of normal cervical spinal canal including the sagittal and transverse diameters as well as Torg ratio. The mean sagittal diameter of cervical spinal canal at C 1 to C 7 ranges from 15.33 mm to 20.46 mm, ...

  4. Optimizing the chemical aspect of root canal irrigation

    OpenAIRE

    Wesselink, P.R.; Sluis, van der, J.; Versluis, A.M.; Macedo, de, R.G.

    2013-01-01

    Root canal treatment is aimed at the removal of inflamed and infected tissue present in the root canal system. It will prevent the entrance of new microorganisms or nutrients in order to maintain or create a healthy environment around the root. There is sufficient evidence that shows that traditional endodontic therapy cannot make the root canal system completely free of bacteria. Moreover, it may not always result in complete healing of apical periodontitis, highlighting the need of optimizi...

  5. Choice of root canal irrigants by Serbian dental practitioners

    OpenAIRE

    Tošić Goran; Miladinović Milan; Kovačević Milorad; Stojanović Miodrag

    2016-01-01

    Background/Aim. Root canal treatment is considered to be the one of the most important procedures in endodontic treatment. To irrigate the root canal it is most common to use sodium hypochlorite (NaOCl), chlorhexodine, ethylenediami-netetraacetic acid (EDTA), local anesthetic solution, while the most used in Serbia is hydrogen peroxide (H2O2). The aim of this survey was to reveal the preferred root canal irrigants used by general dental practitioners in Ser...

  6. ROOT CANAL IRRIGANTS AND IRRIGATION TECHNIQUES: A REVIEW

    OpenAIRE

    Aniketh; Mohamed; Geeta; Nandakishore; Gourav Kumar; Patrick Timothy; Jayson Mathew; Sahle Abdul

    2015-01-01

    Root canal irrigation is not much emphasised in endodontic therapy. Most articles discussed are on root canal shaping and obturation not much emphasis is given for irrigation. There are many irrigation solutions which are introduced into market. The primary objective of root canal therapy is the ret ention of the pulpless or pulpally involved tooth with its associated periapical tissues in a healthy state. Achievement of this objective requires that the pulpal spaces and con...

  7. Interactions between root canal irrigants, sealers and dentin

    OpenAIRE

    Neelakantan, P.

    2016-01-01

    The objective of this thesis was to determine the interactions between root filling materials and root dentin and to investigate if root canal irrigating solutions had an impact on these interactions. The following outcomes were assessed in the studies encompassed in this thesis: (i) dislocation resistance of an epoxy resin based root canal sealer and tricalcium silicate based root canal sealers, (ii) the influence of irrigation protocols on the sealing ability and chemical interactions with ...

  8. Mapping ear canal movement using area-based surface matching

    Science.gov (United States)

    Grenness, Malcolm J.; Osborn, Jon; Weller, W. Lee

    2002-02-01

    Movement of the external ear canal, associated with jaw motion, relative to the concha region of the pinna has been studied. Pairs of open-jaw and closed-jaw impressions were taken of 14 ears from 10 subjects. Three-dimensional coordinate data were obtained from the concha and the anterior surface of the canal using a reflex microscope. Proprietary area-based matching software was used to evaluate distortion of the two surfaces between the two jaw positions. The canal data from each pair were placed into the same coordinate system with their respective concha regions aligned. Difference maps of the canal data were used to demonstrate the amount of anterior-posterior (A-P), superior-inferior (S-I), and medial-lateral (M-L) movement, relative to the concha, that occurred between the open- and closed-jaw impressions. The concha regions did not undergo significant deformation. The canal regions underwent varying amounts of deformation with all canals conforming within an rms of 136 μm across the entire surface. The majority of canals underwent significant movement relative to the concha. M-L movement ranged from +2.0 to -3.8 mm; eight canals moved laterally, five moved medially, and two showed no movement. S-I movement ranged from +3.7 to -2.7 mm; nine canals moved inferiorly, two moved superiorly, and three showed no movement. A-P movement ranged between +7.5 and -8.5 mm, with five canals moving anteriorly, three posteriorly, and four in a mixed fashion. This study has shown the variability of canal movement relative to the concha and does not support previous reports that suggest that the ear canal only widens with jaw opening.

  9. Computed tomography imaging for superior semicircular canal dehiscence syndrome

    International Nuclear Information System (INIS)

    Superior semicircular canal dehiscence is a newly described syndrome of sound and/or pressure induced vertigo. Computed tomography (CT) imaging plays an important role in confirmation of a defect in the bone overlying the canal. A high resolution CT technique utilising 0.5 mm or thinner slices and multi-planar reconstructions parallel to the superior semicircular canal is required. Placement of a histogram over a suspected defect can assist CT diagnosis

  10. Endodontic Considerations in Three-canalled Premolars: A Practical Update.

    Science.gov (United States)

    Mohammadi, Zahed; Shalavi, Sousan; Giardino, Luciano; Asgary, Saeed

    2016-01-01

    The most difficult clinical considertions in orthograde root canal treatment are generally related to the anatomy of the teeth. Three-canalled maxillary and mandibular premolars (mini-molars) have been reported in several studies. The purpose of this paper was to review various aspects of three-canalled premolars including incidence, clinical and radiographic diagnosis, racial predisposition, access cavity preparation, instrumentation and obturation. PMID:27141223

  11. Dinámica sedimentaria y evolución morfológica de un profundo canal del estuario de Bahía Blanca Sedimentary dynamics and morphological evolution of a deep channel in the Bahia Blanca estuary

    Directory of Open Access Journals (Sweden)

    Salvador Aliotta

    2004-03-01

    Full Text Available Al sur de la provincia de Buenos Aires se ubica la región costera de Bahía Blanca. La misma es un extenso sistema mesomareal, con canales de diversas dimensiones y características. El objetivo de esta investigación es analizar los rasgos morfológicos del canal Tres Brazas y su entorno, definiendo dinámica sedimentaria y tendencias evolutivas asociadas. Ondas de arena de hasta 1,5 m de altura y megaóndulas evidencian la migración de los sedimentos. La arena transportada desde el interior del Tres Brazas resulta la fuente de aporte de una barra tipo espiga, que se desarrolla desde la margen derecha de su desembocadura. En tanto, en el interior de los canales Tres Brazas y Tierra Firme son intensos los procesos erosivos sobre sus veriles. Estos, constituidos por material limo arcillo arenoso, según dataciones 14C corresponden a la regresión marina holocena. Las formas acrecionales más significativas son point bars, genéticamente relacionadas a la sedimentación producida por la corriente de reflujo. En la confluencia del Tres Brazas y Tierra Firme se desarrolla una gran depresión de 26 m de profundidad. Sismoestratigráficamente, se define que ésta se originó durante el último período regresivo marino, cuando condiciones turbulentas producidas en el encuentro de los canales de marea habrían iniciado el socavamiento del fondo, generándose una geoforma enteramente erosiva. En una fase posterior, por una mayor disponibilidad de sedimento arenoso, se produce la acreción del flanco sur y sureste, mientras que la erosión del veril norte y noroeste resulta indicativa de la tendencia evolutiva actual.The Bahía Blanca coastal region is located to the south of Buenos Aires Province. It is an extended mesotidal system, with channels of diverse dimensions and characteristics. The objective of this work is to analyse the morphological features of the Tres Brazas channel and its environment, defining sedimentary dynamics and associated

  12. Bone sarcoma induction by 224Ra in Beagles: An interim report

    International Nuclear Information System (INIS)

    During 1963-1968, 20 young adult Beagle dogs were given a single intravenous injection of 224Ra that was unintentionally contaminated with 210Pb and 228Th. All of these dogs have died, eight with bone sarcomas. In addition, 128 Beagle dogs were given purified 224Ra in one, ten or fifty weekly injections during 1977-1979. The acute lethal dosage (LD50) for a single injection was about 400 kBq 224Ra/kg (11 μCi 224Ra/kg). As of September 14, 1987, at the highest skeletal dose of 3 Gy from purified 224Ra, bone sarcomas occurred in 5 of 6 dogs at an average ± SD of 2069 ± 302 days after the start of injections (no survivors), in 4 of 6 dogs at 2485 ± 1,110 days after the start of 10 injections (healthy survivor) and in 1 of 8 dogs at 3066 days after a single injection (3 healthy survivors). At 3 Gy the toxicity of 224Ra relative to 239Pu, based on the ratio of skeletal doses at equal tumor appearance times, was 1.0 for 50 injections of 224Ra, 0.7 for 10 injections, and 0.4 for one injection. In contrast, the effectiveness per Gy of a 224Ra-equivalent dose from a single injection of 224Ra contaminated with 228Th and 210Pb was equal to that from 239Pu, assuming that the 224Ra-equivalent dose equaled the 224Ra dose plus the 228Th dose pus 0.1 of the 210Pb dose. A possible explanation is that protracted irradiation from the 1.91-yr half-life 228Th and the 22.3-yr half-life 210Pb may have 'activated' residual damage from the short-lived, 3.62 day half-life 224Ra, possibly by stimulating the division of damaged stem cells to replace the bone cells killed by the protracted alpha particle irradiation. An important spin off from the study is experimental support for the assumption that the bone sarcoma effectiveness for 210Pb is similar to that from long-lived, 1600 yr half-life 226Ra. (author)

  13. Toxicity of inhaled 90Sr fused clay particles in beagle dogs. V

    International Nuclear Information System (INIS)

    Studies on the metabolism, dosimetry, and biological effects of 90Sr in fused clay particles in Beagle dogs have continued with a view toward defining the biological consequences of inhaling this important radionuclide in a relatively insoluble form. Seventy-two dogs were exposed to a polydisperse aerosol (AMAD 1.4 to 2.8 μm and sigma/sub g/ 1.4 to 2.7) of fused montmorillonite clay particles labeled with 90Sr to achieve graded initial lung burdens (ILB) of 3.7 to 94 μCi/kg body weight; 12 control dogs were exposed to an aerosol of stable strontium in fused clay particles. These 84 dogs were assigned to the 90Sr fused clay longevity study. An additional 26 dogs were exposed similarly (AMAD 1.9 to 2.5 μm and sigma/sub g/ 1.6 to 2.0) and assigned for sacrifice (Series II) at intervals after exposure to define metabolism and dosimetry of this aerosol in Beagle dogs. Of the 72 longevity dogs, 32 dogs having ILBs of 29 to 94 μCi/kg and cumulative doses to lung to death of 40,000 to 96,000 rads have died from radiation pneumonitis and/or pulmonary fibrosis from 159 to 477 days post-exposure. Fourteen dogs with ILBs of 15 to 36 μCi/kg and cumulative doses to lung to death of 34,000 to 68,000 rads have died from primary pulmonary hemangiosarcomas between 644 and 1214 days post-exposure. In addition, one dog developed a bronchiolo-alveolar carcinoma, another epidermoid carcinoma of the lung and a third, a squamous cell carcinoma in the nasal cavity. The remaining 26 exposed dogs and 12 controls of the longevity study are surviving at 1070 to 1707 days post-exposure. Dogs in the sacrifice series have been sacrificed to 1536 days post-exposure. (U.S.)

  14. Determining optimal transit charges: The Kiel Canal in Germany

    OpenAIRE

    Heitmann, Nadine; Rehdanz, Katrin; Schmidt, Ulrich

    2011-01-01

    The Kiel Canal in Germany connects ports on the Baltic Sea with the rest of the world and is the most-used artificial waterway in the world. Despite this fact, it generates a balance sheet loss. Revenues, which are mainly generated by the transit charge, do not cover its operating expenses. This situation raises the question: What reforms could be made to make the canal generate a balance sheet profit? In this paper, we focus solely on the canal's revenue. Because the canal is a monopoly that...

  15. GeoGebra helps to know canal surfaces better

    Science.gov (United States)

    Bímová, Daniela; Bittnerová, Daniela; Vraštil, Ondřej

    2015-11-01

    GeoGebra 5.0 is the dynamic geometric and mathematic software which dynamic tools allow the user to solve dynamic problems in a plane and as well as in the three-dimensional space. The contribution presents the dynamic applets constructed in GeoGebra 5.0 that show the origin as well as some properties of various kinds of canal surfaces. There are described the applets for constructing the canal surfaces in the paper. Some of the created canal surfaces are compared with the real life canal surface examples.

  16. [Canal infection. Ecological theory and repair with osteodentin].

    Science.gov (United States)

    Muñiz, M A; Zeberio, T

    1991-01-01

    The characteristics of the infection in the root canal are analyzed, specially its development before pulpal necrosis. It is inferred that it is an ecological infection with a function: to decompose the necrosis. Inactivating the infection in the canal by the formocresol technique, calcium hidroxide or with the conventional basic treatment in Endodontics, cleaning, washing, disinfecting and, in this case, with partial obturation of the canal, it is possible to induce a reparation with osteodentine that can cover all the free extension of the canal. PMID:1882104

  17. Morphometric analysis of the cervical spinal canal on MRI.

    Science.gov (United States)

    Matveeva, Niki; Janevski, Petar; Nakeva, Natasha; Zhivadinovik, Julija; Dodevski, Ace

    2013-01-01

    Two useful numerical values, called the Torg ratio and the spinal canal diameter (SC diameter) are widely accepted as reliable morphometric determinants of spinal stenosis. The aims of the study were to examine morphometric determinants of the cervical spinal canal on MRI in both sexes and analyse them as reliable indicators of spinal stenosis. Measurements were made on 50 MR images (sagittal T2 weighted images from C3 to C7) of the cervical spine of patients from the Emergency Centre who had undertaken MRI of the cervical spine in addition to CT for various diagnostic indications. Torg ratio, used in evaluation of the spinal canal stenosis on plain x-ray radiographs, cannot be used as a spinal canal stenosis indicator due to the gender differences in the vertebral bodies' width. Sagittal canal diameters were more spread out in males than in females. MRI enables the value of the space available for the spinal cord, (SAC) to be determined, by subtracting the sagittal diameter of the spinal cord from the sagittal diameter of the spinal canal. Not gender, but individual and level differences in the SAC values were evident (cervical cord enlargement). SAC values relied more on the spinal canal than on the spinal cord, so that the differences in the dimensions of the spinal cord accounted for less variability in the SAC values. MR imaging of the cervical spine provides more accurate cervical canal and spinal cord measurements that could serve as morphometric determinants of the cervical canal stenosis. PMID:24280784

  18. Evaluation of furcation perforation repair by MTA and Cav-Hycal in beagle dog%两种材料修复比格犬髓室底穿孔的效果评价

    Institute of Scientific and Technical Information of China (English)

    侯惠敏; 侯本祥; 卫书盛

    2011-01-01

    Objective To investigate the effect of MTA and Cav-Hycal for the repair of beagle dogs'furcation perforations. Methods Thirty-six premolars of three adult beagle dogs with the root canals filled were randomly divided into two groups. Furcation perforations were made and repaired with either MTA or Cav-Hycal. Twenty-four molars served as the positive and negative contros. Fureation perforations were made and covered with polyvinychlorid in positive control and no furcation perforations were made in negative control The periodontal status were evaluated 1, 4 and 12 weeks after treatment. Results At one week, all experimental teeth showed normal. At 4 weeks, minor to severe bone loss were observed in the two experimental groups. The teeth in positive group showed periodontal pockets with severe bone loss. At 12 weeks, the bone defects were entirely or partly repaired in 12 cases of either MTA or Cav-Hycal group with no periodontal pockets. The bone defects in the positive control group became bigger and the periodontal pockets became deeper. The teeth in negative control group showed nomal. There was no significant difference between MTA and Cav-Hycal group( P >0. 05). Conclusion The effect of MTA and Cav-Hycal on the repair of furcation perforations in beagle dogs was similar.%目的:评价MTA和光固化氢氧化钙修复比格犬牙齿髓室底穿孔的效果.方法:3只成年比格犬的36颗前磨牙根管治疗后做髓室底穿孔模型,随机分为两组,分别采用MTA和光固化氢氧化钙修复穿孔.另外24颗磨牙根管治疗后随机分为阳性和阴性对照组,阳性对照组做髓室底穿孔模型后以聚氯乙烯膜覆盖穿孔,阴性对照组不穿孔.分别于术后1,4,12周进行牙周检查及X线影像学评价.结果:术后1周,各组牙周及X线片检查未见异常.术后4周,两实验组各12例牙周未见异常,各6例牙周破坏,所有样本不同程度骨质破坏;阳性对照组12例牙周破坏伴重度骨质破坏.术后12

  19. Comparison of antimicrobial substantivity of root canal irrigants in instrumented root canals up to 72 h: An in vitro study

    OpenAIRE

    M N Shahani; Subba Reddy, V. V.

    2011-01-01

    Disinfection of the root canal system is one of the primary aims of root canal treatment. This can be achieved through the use of various antimicrobial agents in the form of irrigants and medicaments. The antimicrobial substantivity of 2% chlorhexidine gluconate, 1% povidone iodine, 2.5% hydrogen peroxide followed by 2% sodium hypochlorite, and 2% sodium hypochlorite alone as irrigants was assessed in instrumented root canals. 2% chlorhexidine showed antimicrobial substantivity lasting up to ...

  20. Knowing for controlling: ecological effects of invasive vertebrates in Tierra del Fuego Conocer para controlar: efectos ecológicos de vertebrados invasores en Tierra del Fuego

    Directory of Open Access Journals (Sweden)

    CLAUDIA A SILVA

    2008-03-01

    Full Text Available The Tierra del Fuego (TDF archipelago is recognized as part o the last places on Earth that may still be considered wild. However, this condition may be threatened by the large number of invasive species present on the archipelago. These species can have significant effects on the ecology of the invaded ecosystems, at the genetic as well as at population, community and ecosystem levels. The aim of this study is to, by a bibliographic review, systematize existing information on the ecological impacts these species would be having on the TDF archipelago and detect information gaps in order to orient future research and effective management programs on these species. We restricted our review to vertebrate, non-marine invaders. We determined which species have invaded TDF, described their impacts on the archipelago and evaluated their potential impacts; this last issue was determined by reviewing some of the impacts these species have had in other geographic areas. Our findings indicate that at least nine vertebrate species (Salmo trutta, Salvelinus fontinalis, Oncorhynchus mykiss, Castor canadensis, Ondatra zibethicus, Oryctolagus cuniculus, Pseudalopex griseus, Mustela vison and Sus seroja have wild populations established away from human settlements in TDF. There is some scientific evidence on ecological impacts on the area for only five of these invaders, with the American beaver (Castor canadensis being the species monopolizing the greatest number of studies. These results contrast with the recognition, both in TDF and worldwide, of the potential of most of these species to cause significant ecological impacts, which makes it unlikely that the lack of verified impacts on TDF reflects an absence of significant effects of these invaders on the archipelago. We suggest that future research should focus on determining population density and distribution of these and other (i.e., feral species invasive vertebrates, as well as their impacts mainly on

  1. CAVERNOUS HEMANGIOMA OF THE INTERNAL AUDITORY CANAL

    Directory of Open Access Journals (Sweden)

    Mohammad Hossein Hekmatara

    1993-06-01

    Full Text Available Cavernous hemangioma is a rare benign tumor of the internal auditory canal (IAC of which fourteen cases have been reported so far."nTinnitus and progressive sensorineural hearing loss (SNHL are the chief complaints of the patients. Audiological and radiological planes, CTScan, and magnetic resonance image (MRI studies are helpful in diagnosis. The only choice of treatment is surgery with elective transmastoid trans¬labyrinthine approach. And if tumor is very large, the method of choice will be retrosigmoid approach.

  2. Computed tomography in spinal canal diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Sobota, J.; Dutka, J. (Ustredni Vojenska Nemocnice, Prague (Czechoslovakia))

    1983-09-01

    On a sample of 128 patients examined for suspected disorders of the spinal canal by computed tomography, the experience with the diagnostic possibilities of this quick, accurate and noninvasive imaging technique is demonstrated. The methodology of the examination and the range of obtained information in diagnosing congenital anomalies, traumas and degenerative changes are briefly described. Certain problems and limitations of this method for the diagnosis of tumors are presented. For the assessment of vascular changes and inflammatory processes, computed tomography cannot be expected to be used on a wider scale.

  3. Computed tomography in spinal canal diagnosis

    International Nuclear Information System (INIS)

    On a sample of 128 patients examined for suspected disorders of the spinal canal by computed tomography, the experience with the diagnostic possibilities of this quick, accurate and noninvasive imaging technique is demonstrated. The methodology of the examination and the range of obtained information in diagnosing congenital anomalies, traumas and degenerative changes are briefly described. Certain problems and limitations of this method for the diagnosis of tumors are presented. For the assessment of vascular changes and inflammatory processes, computed tomography cannot be expected to be used on a wider scale

  4. Water Environment Evolution along the China Grand Canal

    Science.gov (United States)

    Mao, F.; Wu, Y. X.; Yang, B. F.; Li, X. J.

    2014-03-01

    The China Grand Canal is one of the earliest canals in the world, having lasted for nearly 3000 years. Even its section canals have a rich history, such as the North-South Grand Canal that was established during the Sui Dynasty, whereas the Beijing-Hangzhou Canal was excavated during the Yuan Dynasty and the east line of the South-to-North Water Diversion. As one of the longest in the world, the China Grand Canal's total length is over 3500 kilometers. This length includes the navigable, unnavigable, and underground sections. Making the best use of situations and according to local conditions, the Chinese people harmoniously constructed the Beijing-Hangzhou Canal with nature. Tens of millions of workers took nearly 3000 years to complete the great shipping system. Navigable sections still exist for up to 900 kilometers and the volume of freight traffic is approximately 300 million tons. The canal remains the main logistical channel of the North-to-South Coal Transportation, South-to-North Water Diversion, and resources circulation. To date, China is promoting the success of heritage application. Part of these efforts is the declaration of the China Grand Canal as a World Cultural Heritage by 2014. In addition, the east route of the South-to-North Water Transfer project is planned to be navigable by 2016. The ancient Beijing-Hangzhou Grand Canal will usher in the new ecological civilization and cultural revival along the canal. This paper presents technical methods of water environment evolution research on the river system, river, and water quality along the Beijing-Hangzhou Canal through the integration of historical literature and modern remote sensing image data. The study carried out water environment investigation and analysis along the Beijing-Hangzhou canal by using ETM, SPOT image data, and GPS measurement data. Spatial and temporal evolution characteristics and regulations of the Beijing-Hangzhou Grand Canal regional water environment in the span of 3000

  5. Water Environment Evolution along the China Grand Canal

    International Nuclear Information System (INIS)

    The China Grand Canal is one of the earliest canals in the world, having lasted for nearly 3000 years. Even its section canals have a rich history, such as the North-South Grand Canal that was established during the Sui Dynasty, whereas the Beijing-Hangzhou Canal was excavated during the Yuan Dynasty and the east line of the South-to-North Water Diversion. As one of the longest in the world, the China Grand Canal's total length is over 3500 kilometers. This length includes the navigable, unnavigable, and underground sections. Making the best use of situations and according to local conditions, the Chinese people harmoniously constructed the Beijing-Hangzhou Canal with nature. Tens of millions of workers took nearly 3000 years to complete the great shipping system. Navigable sections still exist for up to 900 kilometers and the volume of freight traffic is approximately 300 million tons. The canal remains the main logistical channel of the North-to-South Coal Transportation, South-to-North Water Diversion, and resources circulation. To date, China is promoting the success of heritage application. Part of these efforts is the declaration of the China Grand Canal as a World Cultural Heritage by 2014. In addition, the east route of the South-to-North Water Transfer project is planned to be navigable by 2016. The ancient Beijing-Hangzhou Grand Canal will usher in the new ecological civilization and cultural revival along the canal. This paper presents technical methods of water environment evolution research on the river system, river, and water quality along the Beijing-Hangzhou Canal through the integration of historical literature and modern remote sensing image data. The study carried out water environment investigation and analysis along the Beijing-Hangzhou canal by using ETM, SPOT image data, and GPS measurement data. Spatial and temporal evolution characteristics and regulations of the Beijing-Hangzhou Grand Canal regional water environment in the span of

  6. Effect of moderate treadmill exercise on some physiological parameters in untrained Beagle dogs.

    Science.gov (United States)

    Piccione, Giuseppe; Casella, Stefania; Panzera, Michele; Giannetto, Claudia; Fazio, Francesco

    2012-01-01

    The aim of the present study was to evaluate the modifications of some physiological parameters during moderate treadmill exercise in seven healthy Beagle dogs. All animals were submitted to treadmill exercise consisting of walking (15 min), trotting (20 min) and walking (10 min). At every step, rectal temperature (RT) was measured, and the mean heart rate (HR) was assessed. Venous blood samples were collected immediately before starting the treadmill exercise session (at rest), after the end of walking (15 min), trotting (20 min) and walking (10 min), and after 30 min of passive recovery. For immediate assessment of lactate and glucose concentration, blood was analyzed with portable blood lactate and blood glucose analyzers, respectively. Blood was also transferred into sterile glass tubes containing K(3)-ethylenediaminetetraacetic acid (K(3)-EDTA) for evaluation of red blood cells (RBC), white blood cells (WBC), platelets (PLT), hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC). One-way repeated measures analysis of variance (ANOVA) showed a significant effect of treadmill exercise (P<0.05) on RT, HR, lactate, glucose, RBC and Hct. Considering these significant variations, the knowledge of RT, HR, glucose and lactate concentrations, RBC, and Hct, the most suitable and sensitive indicators of response to treadmill exercise in untrained dogs, is essential in order to evidence the individual levels of exercise tolerance, to investigate exercise-related problems and to design specific and individual treadmill protocols. PMID:23095814

  7. Effects of x-irradiation of young female beagles on life span and tumor incidence

    International Nuclear Information System (INIS)

    Causes of death and the occurrence of neoplasia in female beagle dogs were evaluated retrospectively for 57 unexposed and 296 exposed dogs given single or fractionated whole-body x-irradiation exposures of 100 or 300 R. Some dogs subsequently were bred, and all were observed for the duration of their lives. The pathology for these dogs was derived from clinical records, gross-necropsy reports, tissue slides, and Formalin-fixed tissues. The results of this study indicated dose-related shortening of life span was clearly evident; causes of death due to either neoplasia (50%) or nonneoplastic disease (50%), with few exceptions, were similar in control and irradiated dogs; the incidences of neoplasms were not significantly greater for irradiated dogs than for controls, but the latency period decreased as dose increased; protraction increased survival in dogs given 300 R but not 100 R, which is attributable solely to amelioration of incidence rates of nonmammary neoplasia; and the cumulative rates of death due to mammary tumors were the same in dogs exposed to 100 R and 300 R. 14 refs., 6 figs., 2 tabs

  8. Small intestinal emptying time in normal Beagle dogs: a contrast radiographic study

    International Nuclear Information System (INIS)

    Gastric emptying time and small intestinal transit time in dogs are frequently discussed. However, it is often of interest to the radiologist to know what normal small intestinal emptying times should be. A total of 15 upper gastrointestinal studies was performed on five internal parasite-free, normal, standard Beagle dogs with three studies on each dog, 6 days apart. The ages and weights of the dogs ranged from 2–8 years and from 12.4–13.7 kg, respectively. Following 24-hour fasting, a dose of 10 ml/kg bw of 60% wt/vol barium sulfate suspension was administered through a stomach tube. Then, sequential radiographs were made at 30-minute intervals until the entire contrast medium column was in the colon and cecum. The mean, standard deviation, and range of gastric emptying time, small intestinal transit time, and small intestinal emptying time were 76 ± 16.7 (30–120), 73 ± 16.4 (30–120), and 214 ± 25.1 (180–300) minutes, respectively. This study offers the possibility that small intestinal emptying time may be used to further evaluate patients with suspected small intestinal partial obstruction, pseudo-obstruction, ischemia, or lymphangiectasia

  9. Ovariectomy-induced changes in aged beagles: Histomorphometry and mineral content of the rib

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, A.K.; Bhattacharyya, M.H.; Hurst, D. [Argonne National Lab., IL (United States). Center for Mechanistic Biology and Biotechnology; Miller, S. [Univ. of Utah, Salt Lake City, UT (United States). Radiobiology Div.; Sacco-Gibson, N. [Proctor and Gamble Pharmaceuticals, Cincinnati, OH (United States)

    1997-08-01

    The effects of ovariectomy on the aged beagle skeleton were studied by histomorphometric analysis of the cortical bone in sequential rib biopsies. Biopsies were taken from each ovariectomized (OV) or sham-operated (SO) dog at the time of surgery and at 1, 4, and 8.5 months after surgery. Tetracycline, calcein, and xylenol orange, respectively, were administered by a fluorochrome labeling procedure (2d-10d-2d) just prior to each postoperative biopsy to provide markers of bone formation. Analysis of sequential biopsies provided a means to follow the response to ovariectomy over time and compare each animal against its own baseline. Examination of sequential biopsies indicated that cortical porosity increased by the fourth month after ovariectomy and remained high at 8.5 months. Ovariectomy did not influence histomorphometric indices at one month after surgery, but substantial differences were observed at later times. Ovariectomy stimulated a transient increase in bone formation and was increased six-fold over that of SO dogs at four months. Ribs were also analyzed for mineral content at necropsy. The rib was heterogeneous along its length for calcium content and concentration. In the midrib where biopsies for histomorphometric analysis were taken, ovariectomy induced a decrease in mass and mineral content; total calcium was decreased by approximately 31%. These data demonstrate that the rib cortical bone is a responsive site for the effects of ovariectomy in female dogs.

  10. Lifetime radiation risks from low-dose rate radionuclides in beagles

    International Nuclear Information System (INIS)

    One of the largest, long-term (25-yr) animal studies on the effects of low-dose internal irradiation is almost completed. Some 335 beagles were given continuous exposure to graded 90Sr [low linear energy transfer (LET)] in their diets (D-dogs) through adulthood. A second group (R-dogs) was given fractionated doses of 225Ra (high LET) as young adults. A third group of 44 was given a single injection of 90Sr as adults (S-dogs) to compare single to continuous dosages. All dogs were followed through their lifetimes. Only one of the 848 dogs is still alive. The animals were whole-body counted over their entire life span and were examined frequently for assessment of medical status. There were no acute radiation lethalities. Analyses of the large data base from these dogs have begun and preliminary indications are that 90Sr, which was tested over a 1500-fold skeletal dose rate range, does not cause significant life shortening at average accumulation skeletal doses of ∼2500 rads (25 Gy) and that a curvilinear dose response curve for life shortening was seen at higher accumulation doses. The data will be discussed in terms of modern epidemiological concepts and quantifications will be related to certain parameters of human risk from acute or chronic radiation exposures

  11. Toxicity of 144Ce inhaled in a relatively insoluble form by immature Beagle dogs. XII

    International Nuclear Information System (INIS)

    Immature Beagle dogs (3 months old) were exposed once by inhalation to an aerosol of 144Ce incorporated in fused aluminosilicate particles. The influence of this age on the dose-response relationships is being compared to that of 13-mo-old and 8 to 10.5-yr-old dogs. This study involves 49 dogs that received graded initial lung burdens from 0.004 to 140 μCi 144Ce/kg body weight and five control dogs. To date, 19 of the 144Ce-exposed dogs and one of the controls have died. Dogs with the highest initial lung burdens of 144Ce died during the first 4 months with radiation pneumonitis, pulmonary fibrosis, and congestive heart failure. Pulmonary hemangiosarcoma was the primary finding in dogs that died at 1.5 to 2 years after exposure. Deaths beyond that time have been due primarily to extrapulmonary hemangiosarcomas. Observations are continued on the surviving 30 144Ce-exposed and four control dogs at 7.0 to 11.2 years after exposure

  12. Toxicity of 90Sr inhaled in relatively insoluble form by Beagle dogs. XV

    International Nuclear Information System (INIS)

    Beagle dogs were exposed by inhalation to 90Sr in a relatively insoluble form to study long-term health effects. Lung burdens ranged from 0.12 to 96 μCi (4.4 to 3550 kBq) of 90Sr/kg body weight. High levels of exposure resulted in radiation pneumonitis and pulmonary fibrosis; lower level exposures caused long-term effects, including cancer of the lung, heart, and tracheobronchial lymph nodes. Most of these tumors were hemangiosarcomas. Two control dogs and four 90Sr-exposed dogs died or were euthanized during the past year. One exposed dog died with hemangiosarcoma of the heart and pulmonary adenoma, another exposed dog died with angiosarcoma of tracheobronchial lymph nodes, another exposed dog died with hemangiosarcoma of the heart, and the fourth exposed dog died with hemangiosarcoma of tracheobronchial lymph nodes. One control dog died with adenocarcinoma of the prostate, and the other control dog died with adenocarcinoma of the pancreas. The remaining 15 exposed and 9 control dogs are being maintained for lifetime observation. 2 figures, 1 table

  13. Nasal carcinomas in beagle dogs after inhalatioon of relatively soluble forms of beta-emitting radionuclides

    International Nuclear Information System (INIS)

    Beagle dogs were exposed by inhalation to relatively soluble forms of three beta-emitting radionuclides and are being held for life span observation to evaluate hazards associated with nuclear power production. Dogs were exposed to graded activity levels of 91YCl3, 144CeCl3 or 90SrCl2. With 91YCl3 and 144CeCl3, significant radiation dose was delivered to liver, respiratory tract, and skeleton. With 90SrCl2, the dose was essentially to skeleton. Nasal cavity squamous cell carcinomas have been the most frequent neoplasms in the 91Y and one of the most frequent in the 144Ce study while relatively few have been seen after 90Sr exposure. Also one nasal cavity hemangiosarcoma was seen in the 144Ce study. The 90Sr-exposed dogs have survived longer after exposure and have higher skeletal radiation doses than do the dogs exposed to 91Y or 144Ce. The greater incidence of nasal carcinomas can be explained by the finding of high concentrations of the lanthanides, 91Y and 144Ce, associated with the nasal turbinate epithelium

  14. Current status of life-span studies with inhaled plutonium in beagles at Pacific Northwest Laboratory

    International Nuclear Information System (INIS)

    Beagles that inhaled 239PuO2, 238PuO2, or 239Pu(NO3)4, in dose-level groups of 20 dogs, with initial lung burdens of ∼2, 15, 70, 300, 1100, or 5500 nCi, are now 11, 9, or 5 years postexposure. Lung tumors, bone tumors, and radiation pneumonitis, the plutonium-exposure-related causes of death observed to date, have occurred in the two, three, and four highest dose-level groups exposed to 238PuO2, 239Pu(NO3)4, and 239PuO2, respectively. No plutonium-exposure-related deaths have thus far been observed in dose-level groups exposed to less than ∼40 times the current maximum permissible lung dose for a plutonium worker. Plutonium-exposure-related effects not directly related to the cause of death include chronic lymphopenia, chronic neutropenia, sclerosis of the tracheobronchial lymph nodes, focal radiation pneumonitis, adenomatous hyperplasia in the liver, and dystrophic osteolytic lesions in the skeleton. No plutonium-exposure-related effects have thus far been observed in dose-level groups that received less than ∼15 times the current maximum permissible lung dose for a plutonium worker. 10 refs., 5 figs., 4 tabs

  15. Regional effects of ovariectomy and cadmium on bone mineral in ribs from aged female beagles

    Energy Technology Data Exchange (ETDEWEB)

    Hurst, D.R. (Miami Univ., Oxford, OH (USA). Dept. of Zoology)

    1991-01-01

    The purpose of this study was to evaluate effects of estrogen depletion and cadmium (Cd) on bone calcium and to determine if these effects were localized in specific regions of ribs. Fourteen female beagles with {sup 45}Ca labeled skeletons were divided into four groups: sham controls (SO{minus}); ovariectomized (OV{minus}); shams exposed to Cd (SO+); ovariecomized exposed to Cd (OV+). Total Cd exposure period was 7 months, including 1 month by capsules and 6 months by drinking H{sub 2}O. Ribs were taken at necropsy from 12 of the 14 dogs, and each rib was quartered. Wet, dry, and ash weights, as well as total Ca and {sup 45}Ca content, were determined for each quarter. Analysis of ribs from control animals demonstrated that a given rib is heterogeneous in composition. One end appears to be less mineralized and more metabolically active than other regions. The OV{minus} and OV+ mid-rib regions had significantly lower dry and ash weights than SO{minus}. Total Ca contents of these same regions were also decreased in the OV{minus} and OV+. The only significant change in Ca/dry and Ca/ash was observed when comparing OV+ to SO{minus}. Analysis of treatment suggests that there are regional effects following ovariectomy increased the loss of bone mineral occurring as a result of ovariectomy. 30 refs., 1 fig.

  16. Biokinetics aand dosimetry of inhaled 238PuO2 in the beagle dog: An update

    International Nuclear Information System (INIS)

    The temporal and spatial distributions of 238Pu have been measured during the course of a dose-response study of the biological effects of inhaled 238PuO2 in Beagle dogs. These measurements were done on the dose-response study animals, as well as a separate group of dogs exposed to similar aerosols and killed serially out to 4 y after exposure. The data from this latter group provided the basis for the development of a biokinetic/dosimetric model for 238PuO2 in dogs. Since the publication of this model, several important findings have been made that affected the dosimetric evaluations. The first involved the discovery of significant quantities of natural uranium (U) in the feces samples. The U was measured with the plutonium (Pu), which inflated the values for purported Pu in feces. The second finding involved the addition of Pu biokinetics data from the dose-response dogs, which increased the period of observation from 4 y to 15 y; these later data were not consistent with the earlier model predictions. The purpose of this investigation was (1) to remove the analytical bias in the 238Pu radiochemical data due to the U and (2) to modify the original model of Mewhinney and Diel, taking into account all data from both studies

  17. Study on toxicity of danshensu in beagle dogs after 3-month continuous intravenous infusion.

    Science.gov (United States)

    Li, Guisheng; Gao, Yonglin; Li, Shenjun; Li, Chunmei; Zhu, Xiaoyin; Li, Min; Liu, Zhifeng

    2009-09-01

    Danshensu (3-(3,4-dihydroxyphenyl) lactic acid), a natural phenolic acid, is isolated from root of Salvia miltiorrhiza, and is widely used as a traditional Chinese medicine for treatment of various cardiovascular diseases. In the present study, toxicity of danshensu was evaluated in male and female dogs after 3-month continuous intravenous infusion. Beagle dogs were treated with danshensu at doses of 17, 50, and 150 mg/kg/day, and observed for 90 days followed by recovery periods. Measurements included clinical observations, body weight, food consumption, temperature, electro-cardiography (EGC), hematology, blood chemistry, urinalysis, gross necropsy, organ weight, and histopathology. No significant adverse effects on these parameters were observed. The only treatment-related finding was a hard knot at injection site observed in the 150 mg/kg group after 2-3 weeks continuous administration, and returned to normal after 3-4 days withdrawal. From these results, it might be concluded that danshensu did not produce any significant cumulative toxicity at the doses administered, as reflected by the various parameters investigated. PMID:19778246

  18. Regional effects of ovariectomy and cadmium on bone mineral in ribs from aged female beagles

    International Nuclear Information System (INIS)

    The purpose of this study was to evaluate effects of estrogen depletion and cadmium (Cd) on bone calcium and to determine if these effects were localized in specific regions of ribs. Fourteen female beagles with 45Ca labeled skeletons were divided into four groups: sham controls (SO-); ovariectomized (OV-); shams exposed to Cd (SO+); ovariecomized exposed to Cd (OV+). Total Cd exposure period was 7 months, including 1 month by capsules and 6 months by drinking H2O. Ribs were taken at necropsy from 12 of the 14 dogs, and each rib was quartered. Wet, dry, and ash weights, as well as total Ca and 45Ca content, were determined for each quarter. Analysis of ribs from control animals demonstrated that a given rib is heterogeneous in composition. One end appears to be less mineralized and more metabolically active than other regions. The OV- and OV+ mid-rib regions had significantly lower dry and ash weights than SO-. Total Ca contents of these same regions were also decreased in the OV- and OV+. The only significant change in Ca/dry and Ca/ash was observed when comparing OV+ to SO-. Analysis of treatment suggests that there are regional effects following ovariectomy increased the loss of bone mineral occurring as a result of ovariectomy. 30 refs., 1 fig

  19. Sub-chronic safety evaluation of the ethanol extract of Aralia elata leaves in Beagle dogs.

    Science.gov (United States)

    Li, Fengjin; He, Xiaoli; Niu, Wenying; Feng, Yuenan; Bian, Jingqi; Kuang, Haixue; Xiao, Hongbin

    2016-08-01

    Aralia elata Seem. (A. elata) is a traditional Chinese medicine to treat some diseases. This investigation aims to evaluate the pharmaceutical safety of the ethanol extract of A. elata leaves, namely ethanol leaves extract (ELE), in Beagle dogs. In sub-chronic oral toxicity study, dogs were treated with the ELE at doses of 50, 100 and 200 mg/kg for 12 weeks and followed by 4 weeks recovery period. During experimental period, clinical signs, mortality, body temperature, food consumption and body weight were recorded. Analysis of electrocardiogram, urinalysis, ophthalmoscopy, hematology, serum biochemistry, organ weights and histopathology were performed. The results showed that both food consumption and body weight significantly decreased in high-dose group. Treatment-related side effects and mortality were observed in high-dose female dogs. Some parameters showed significant alterations in electrocardiogram, urinalysis, serum biochemistry and relative organ weights. These alterations were not related to dose or consistent across gender, which were ascribed to incidental and biological variability. The findings in this study indicated that the no-observed adverse effect level (NOAEL) of the ELE was 100 mg/kg in dogs and provided a vital reference for selecting a safe application dosage for human consumption. PMID:27156779

  20. Effect of inhaled 90Y in fused clay particles on the gastrointestinal tract of beagle dogs

    International Nuclear Information System (INIS)

    Ten Beagle dogs were exposed by inhalation to aerosols of 90Y in fused clay particles to study the radiation dose to the gastrointestinal (GI) tract and effects resulting from clearance of the upper respiratory tract after the deposition of high initial body burdens of inhaled 90Y. Focal colonic lesions were found in 2 dogs, 8 and 12 days after inhalation of 90Y which resulted in transient GI burdens (GIB) of 18 and 34 mCi. Similar, but less severe, lesions were found in 2 dogs sacrificed 27 days after exposure with GIBs of 18 and 32 mCi. No GI lesions were found in 6 dogs with GIBs of 9 to 18 mCi. Two of the 10 dogs had thermoluminescent dosimeters surgically implanted in the GI tract lumen and submucosa. Highest radiation doses were measured in the colon. One dog, with measured doses to the colon of 3200 to 5700 rads, had focal colitis when sacrificed 8 days after exposure. The other dog, with doses to colon of 1000 to 2800 rads had no GI lesions at sacrifice 8 days after exposure. Although focal colitis was found, no dogs died due primarily to GI injury. Other significant findings were nasal dermatitis and radiation pneumonitis. The latter was more severe and life threatening than the GI injury. (U.S.)

  1. Deposition of Crocidolite asbestos and glass microfibers inhaled by the beagle dog

    International Nuclear Information System (INIS)

    The respiratory tract deposition of neutron activated Crocidolite asbestos and glass microfibers was determined in two groups of four Beagle dogs. The dogs were given 60-minute, nose-only inhalation exposures to an aerosol of either asbestos or glass fibers. The radioactivity in tissues and excreta four days after exposure was used to determine the fraction of inhaled fibers deposited in the upper respiratory tract and the deep lung. The activity median aerodynamic diameter (AMAD), count median diameter (CMD) and count median length (CML) were determined from fibers sampled during exposure. Crocidolite asbestos fibers had an AMAD of 1.8 μm, a CMD of 0.25 μm and a CML < 5 μm. The fraction of inhaled mass deposited in deep lung was 13-19%, while total deposition in the respiratory tract was 54-72%. Glass microfibers had an AMAD of 2.5 μm, a CMD of 0.15 μm and a CML of 5.4 μ. Five to 17% of the mass of glass fiber was deposited in the deep lung; total respiratory tract deposition was 45-64%. The deposition patterns were similar for these small asbestos and glass fibers inhaled by dogs and in good agreement with previous predictions made for man. 24 references, 4 figures, 5 tables

  2. Upper gastrointestinal examinations: a radiographic study of clinically normal Beagle puppies

    International Nuclear Information System (INIS)

    A total of 24 upper gastrointestinal examinations were performed on four weanling beagle puppies over six weeks, using liquid barium (10 ml/kg body weight of 60 per cent w/v barium sulphate suspension] and barium food (8 g/kg of crushed kibble dog food and 7 ml/kg body weight of 60 per cent w/v barium sulphate suspension) as contrast media. The radiographic appearance was similar to that noted in adult dogs except for the consistent location of the pylorus on or near the midline. Duodenal pseudoulcers were seen more often with liquid barium and the caecal shadows were identified more often with the longer examination time with barium food. The stomach of the puppies appeared to have discriminatory emptying function; that is, semi-solid food was emptied from the stomach at a slower rate (210 to 450 minutes) than liquid (60 to 90 minutes). Solid meals emptied faster in puppies than in adult dogs. Dosages of 13 to 15 mg/kg body weight for the liquid barium examination and 14 g of ground kibble and 16 ml of barium sulphate suspension per m2 of body surface area for the barium food examination are suggested as more appropriate for contrast studies in puppies

  3. Toxicity of 144Ce inhaled in a relatively insoluble form by aged Beagle dogs. XII

    International Nuclear Information System (INIS)

    The toxicity of relatively insoluble 144Ce inhaled by 8- to 10.5-year-old Beagle dogs is being investigated to determine possible age-related differences in long-term biological responses. Forty-two dogs were exposed to aerosols of 144Ce in fused aluminosilicate particles to yield initial lung burdens of 2.2 to 75 μCi 144Ce/kg body weight, and 12 control dogs were exposed to non-radioactive fused aluminosilicate particles. All 144Ce-exposed and control dogs have died or were euthanized between 197 and 2726 days after the inhalation exposure. Prominent findings in the 144Ce-exposed dogs were radiation pneumonitis in 19 of the 23 dogs that died during the first 943 days after exposure, and neoplastic disease in 13 of the 20 dogs that died beyond 904 days after exposure. Pulmonary tumors were found in five of these dogs. In contrast to the study with young adult dogs, in which pulmonary hemangiosarcomas were one of the prominent findings, all of these tumors were carcinomas

  4. Impact of release characteristics of sinomenine hydrochloride dosage forms on its pharmacokinetics in beagle dogs

    Institute of Scientific and Technical Information of China (English)

    Jin Sun; Jie-Ming Shi; Tian-Hong Zhang; Kun Gao; Jing-Jing Mao; Bing Li; Ying-Hua Sun; Zhong-Gui He

    2005-01-01

    AIM: To investigate the effect of release behavior of sustained-release dosage forms of sinomenine hydrochloride dosage forms, including commercial 12-h sustained-release tablets and 24-h sustained-release pellets prepared in our laboratory, was examined. The two dosage forms were orally administrated to beagle dogs, and then the in vivo formulation was achieved by mixing slow- and rapid-of the sustained-release pellets were scarcely influenced by the pH of the dissolution medium. Release from the 12-h sustained-release tablets was markedly quicker than that from the 24-h sustained-release pellets, the cumulative release up to 12-h was 99.9% vs68.7%. From release pellets had longer tmax and lower Cmax compared to the 12-h sustained-release tablets, the tmax being 2.67±0.52 h vs9.83±0.98 h and the Cmax being 1 334.45±368.76 ng/mL vs 893.12±292.55 ng/mL, respectively. However, the AUC0-tn preparations were statistically bioequivalent. Furthermore,percentage absorption in vivo and the cumulative percentage release in vitro.CONCLUSION: The in vitro release properties of the dosage forms strongly affect their pharmacokinetic behavior in vivo. Therefore, managing the in vitro release behavior of dosage forms is a promising strategy for obtaining the optimal in vivo pharmacokinetic characteristics and safe therapeutic drug concentration-time curves.

  5. Omental leiomyosarcoma with unusual giant cells in a Beagle dog - Short communication.

    Science.gov (United States)

    Sasaki, Jun; Toyoshima, Megumi; Okamura, Yasuhiko; Goryo, Masanobu

    2016-06-01

    A 10-year-old castrated male Beagle dog was presented with a 2-month history of intermittent vomiting and abdominal pain. The dog was referred to the Veterinary Teaching Hospital at Iwate University for further evaluation, and a splenic tumour was suspected on the basis of ultrasonography and computed tomography. Surgery identified a large, solid, light-pink mass on the greater omentum with blood-coloured ascites in the abdominal cavity, and resection was performed. Microscopically, the mass comprised spindle-shaped tumour cells and scattered osteoclast-like giant cells. Most spindle-shaped cells were positive for vimentin, desmin, and smooth muscle actin (α-SMA), whereas osteoclast-like giant cells were positive only for vimentin. On the basis of histopathological and immunohistochemical findings, a diagnosis of leiomyosarcoma was made. To the best of our knowledge, this represents the first report of leiomyosarcoma associated with osteoclast-like giant cells developing from the greater omentum in a dog. PMID:27342093

  6. Root canal treatment of mandibular second premolar tooth with taurodontism

    Directory of Open Access Journals (Sweden)

    Vujašković Mirjana

    2008-01-01

    Full Text Available INTRODUCTION Taurodontism is a morphoanatomical change in the shape of a tooth. An enlarged body of a tooth with smaller than usual roots is a characteristic feature. Internal tooth anatomy correlates with this appearance, which means that a taurodontal tooth has a large pulp chamber and apically positioned furcations. This dental anomaly may be associated with different syndromes and congenital discoders. CASE OUTLINE The case report presents the patient of a rare case of taurodontism in the mandibular second premolar with chronic periodontitis. Endodontic treatment was performed after dental history and clinical examination. Special care is required in all segments of endodontic treatment of a taurodontal tooth from the identification orifice, canal exploration, determining working length, cleaning and shaping and obturation of the root canal. Precurved K-file was used for canal exploration and location of the furcation. One mesial and one distal canal with the buccal position were identified in the apical third of the root canal. The working lengths of two canals were determined by radiographic interpretation with two K-files in each canal and verified with the apex locator. During canal instrumentation, the third canal was located in the disto-lingual position. The working length of the third canal was established using the apex locator. CONCLUSION Thorough knowledge of tooth anatomy and its variations can lead to lower percentage of endodontic failure. Each clinical case involving these teeth should be investigated carefully, clinically and radiographically to detect additional root canals. High quality radiographs from different angles and proper instrumentarium improve the quality of endodontic procedure.

  7. Root canal filling evaluation using optical coherence tomography

    Science.gov (United States)

    Negrutiu, Meda L.; Sinescu, Cosmin; Topala, Florin; Nica, Luminita; Ionita, Ciprian; Marcauteanu, Corina; Goguta, Luciana; Bradu, Adrian; Dobre, George; Rominu, Mihai; Podoleanu, Adrian Gh.

    2010-04-01

    Endodontic therapy consists in cleaning and shaping the root canal system, removing organic debris and sealing the intra-canal space with permanent filling materials. The purpose of this study was to evaluate various root canal fillings in order to detect material defects, the marginal adaptation at the root canal walls and to assess the quality of the apical sealing. 21 extracted single-root canal human teeth were selected for this study. We instrumented all roots using NiTi rotary instruments. All canals were enlarged with a 6% taper size 30 GT instrument, 0,5 mm from the anatomical apex. The root canals were irrigated with 5% sodium hypochlorite, followed by 17% ethylenediaminetetraacetic acid (EDTA). After the instrumentation was completed, the root canals were obturated using a thermoplasticizable polymer of polyesters. In order to assess the defects inside the filling material and the marginal fit to the root canal walls, the conebeam micro-computed tomography (CBμCT) was used first. After the CBμCT investigation, time domain optical coherence tomography working in en face mode (TDefOCT) was employed to evaluate the previous samples. The TDefOCT system was working at 1300 nm and was doubled by a confocal channel at 970 nm. The results obtained by CBμCT revealed no visible defects inside the root-canal fillings and at the interfaces with the root-canal walls. TDefOCT investigations permit to visualize a more complex stratificated structure at the interface filling material/dental hard tissue and in the apical region.

  8. La territorialidad del indígena americano de la tierra alta del norte de la Baja California

    Directory of Open Access Journals (Sweden)

    Ralph Michelsen

    1991-01-01

    Full Text Available Ralph Michelsen explora la idea de territorialidad entre los indígenas de Baja California como sujetos de otro tipo de realidad; un tiempo cuando el usufructo de la tierra se ceñía a reglas aborígenes particulares en contraste con las formas de tenencia de la tierra actuales y la noción de "país" que en el mundo prevalece. Su finalidad se logra mediante una reconstrucción histórica que le permite hacer propuestas sobre la percepción del espacio geográfico por los miembros de unidades lingüísticas y/o de parentesco.

  9. Management of mandibular first molar with four canals in mesial root

    OpenAIRE

    Subbiya, Arunajatesan; Kumar, Krishnamurthy Sathish; Vivekanandhan, Paramasivam; Prakash, Venkatachalam

    2013-01-01

    Successful root canal treatment depends on adequate cleaning, shaping, and filling of the root canal system. The presence of middle mesial (MM) root canal of mandibular molars has been reported by various authors. But incidence of four canals in mesial root of mandibular molar is very rare. The aim of this case report is to present and describe the identification and management of a mandibular first molar with four canals in the mesial root and single canal in the distal root.

  10. Use of ATLANTIS TIERRA 2.0 in mapping the biodiversity (invertebrates and bryophytes) of caves in the Azorean archipelago

    OpenAIRE

    Paulo A V Borges; Gabriel, Rosalina; Pereira, Fernando E. A. P.; Mendonça,Enésima; Sousa, Eva

    2008-01-01

    XII International Symposium on vulcanospeleology. Tepoztlan, Morelos, Mexico, July 2-7, 2006. In this contribution the software ATLANTIS Tierra 2.0 is described as a promising tool to be used in the conservation management of the animal and plant biodiversity of caves in Macaronesia. In the Azores, the importance of cave entrances to bryophytes is twofold: i) since these are particularly humid, sheltered habitats, they support a diverse assemblage of bryophyte species and circa 25% of the ...

  11. Structural geology of the Fuegian Andes and Magallanes fold-and-thrust belt - Tierra del Fuego Island

    OpenAIRE

    Menichetti, Marco; Lodolo, Emanuele; Tassone, Alejandro

    2008-01-01

    A synthesis of the structural geology of the Tierra del Fuego Island, which integrates a new data set derived from field surveys and literature data of the last few years, is presented here. The main geological features of the region developed during the Mesozoic-Cenozoic Andean orogenic cycle that started in the Middle to Late Jurassic with a back-arc extension, crustal stretching and widespread volcanism, related to the break-up of Gondwanaland. An extensional fault system deriving from the...

  12. Effect of resource spatial correlation and hunter-fisher-gatherer mobility on social cooperation in tierra del fuego

    OpenAIRE

    José Ignacio Santos; María Pereda; Débora Zurro; Myrian Álvarez; Jorge Caro; José Manuel Galán; Ivan Briz i Godino

    2015-01-01

    This article presents an agent-based model designed to explore the development of cooperation in hunter-fisher-gatherer societies that face a dilemma of sharing an unpredictable resource that is randomly distributed in space. The model is a stylised abstraction of the Yamana society, which inhabited the channels and islands of the southernmost part of Tierra del Fuego (Argentina-Chile). According to ethnographic sources, the Yamana developed cooperative behaviour supported by an indirect reci...

  13. Effect of Resource Spatial Correlation and Hunter-Fisher-Gatherer Mobility on Social Cooperation in Tierra del Fuego

    OpenAIRE

    Santos, José Ignacio; Pereda, M; Zurro Hernández, Débora; Álvarez, Myrian; Caro Saiz, Jorge; Galán, José Manuel; Briz i Godino, Iván

    2015-01-01

    This article presents an agent-based model designed to explore the development of cooperation in hunter-fisher-gatherer societies that face a dilemma of sharing an unpredictable resource that is randomly distributed in space. The model is a stylised abstraction of the Yamana society, which inhabited the channels and islands of the southernmost part of Tierra del Fuego (Argentina-Chile). According to ethnographic sources, the Yamana developed cooperative behaviour supported by a...

  14. ANÁLISIS PRELIMINAR DEL TRATAMIENTO FISICOQUÍMICO Y BIOLÓGICO DEL ACEITE DIELÉCTRICO PRESENTE EN TIERRA FULLER

    Directory of Open Access Journals (Sweden)

    EDISON ALEXANDER AGUDELO

    2011-01-01

    Full Text Available Este estudio evalúa dos tecnologías: una físico-química y otra biológica, que buscan eliminar la contaminación por el aceite dieléctrico presente en la tierra Fuller, Buscando con ello gestionar de forma ambientalmente adecuada este residuo peligroso. Para la Tecnología físico-química, se usó hexano como solvente y se alcanzó de manera preliminar remociones del aceite dieléctrico del orden del 87% en la tierra Fuller tratada, con una relación tierra Fuller: solvente de 1:8 p/v, una velocidad de agitación de 100 rpm y un tiempo de contacto de 30 minutos. La calidad del aceite dieléctrico recuperado no es apta para su uso en equipos eléctricos, por su baja rigidez dieléctrica, baja densidad y color desfavorable. La tierra Fuller recuperada alcanzó una densidad aparente de 0.623 gr/ml, una densidad real de 2.231 gr/ml y una porosidad de 72.075 %, lo que indica al menos preliminarmente que dicha tierra está muycercana en sus características físicas a la tierra fuller limpia. Para la tecnología biológica se trató la tierra contaminada en un reactor biológico de tierra activada, evaluando la velocidad de agitación y el tiempo de degradación necesario para alcanzar niveles de contaminación adecuados que permitan disponer el residuo en un relleno sanitario convencional sin riesgo para la salud de los ecosistemas y el ser humano, esta fase aún se encuentra en experimentación y los resultados dependen del análisis cromatográfi co del aceite dieléctrico que permanece en la tierra Fuller tratada, en el cual se hará el seguimiento de 10 especies que son clave dentro de este producto, debido a su cantidad y/o toxicidad , falta comprobar la calidad química de la tierra fuller y del aceite dieléctrico recuperados en el tratamiento físico-químico, y validar el proceso biológico para degradar el aceite dieléctrico.

  15. PERSPECTIVAS DEL PROCESO DE TITULACIÓN DE TIERRAS EN LA COMUNIDAD CAMPESINA SAN JUAN DE MIRAFLORES, 2011

    Directory of Open Access Journals (Sweden)

    Roger Ricardo Ríos Ramirez

    2014-12-01

    Full Text Available El objetivo del trabajo fue evaluar las perspectivas hacia la titulación de tierras en la Comunidad Campesina San Juan de Miraflores (CCSJM.El estudio fue de tipo descriptivo, con un diseño no experimental transversal. Se aplicó un cuestionario estructurado para evaluar perspectivas a una muestra de 353 comuneros seleccionados de manera aleatoria, estratificada y proporcional, previa validación de expertos y con una confiabilidad alfa de Cronbach α =  0.944.En la CCSJM, las parcelas no tienen las características necesarias para que la agricultura o ganadería se desarrollen, asimismo la actividad campesina no es la principal actividad económica. Asimismo, los comuneros de la CCSJM muestran una perspectiva favorable hacia la titulación de tierras.Por lo tanto, consideramos imperante el proceso de titulación de tierras y la promoción de opciones laborales distintas a las que usualmente realiza un campesino.

  16. Negociando la tierra: empresas extranjeras, minería a gran escala y derechos humanos en Colombia

    Directory of Open Access Journals (Sweden)

    Juan David Velasco

    2014-01-01

    Full Text Available La adquisición masiva de tierras por parte de empresas extranjeras en países africanos, asiáticos y latinoamericanos refleja una nueva fase del capitalismo global (Sassen, 2013. Colombia no ha escapado a esta lógica mundial del capitalismo, pues en la última década la influencia de las empresas extranjeras en el mercado de tierras ha sido notoria. En esa lógica, este artículo compara, desde un enfoque de Derechos Humanos, las prácticas de adquisición de tierras de tres compañías extranjeras que han explotado carbón a cielo abierto en La Guajira y Cesar. Los resultados indican que la formalidad de la propiedad agraria y las restricciones institucionales de las empresas —asociadas al gobierno corporativo, la participación en bolsa de valores y el veto de compradores internacionales—influyen significativamente en el respeto a los derechos humanos.

  17. Lichen Usnea barbata as biomonitor of airborne elements deposition in the Province of Tierra del Fuego (southern Patagonia, Argentina).

    Science.gov (United States)

    Conti, Marcelo Enrique; Pino, Anna; Botrè, Francesco; Bocca, Beatrice; Alimonti, Alessandro

    2009-05-01

    Lichen Usnea barbata was tested as a possible biomonitor of atmospheric deposition in a supposedly pristine environment Tierra del Fuego (Argentina). Lichen samples were collected in 2005 and again in 2006 in 71 sites covering almost the entire region. The aim of the study was to evaluate the bioaccumulation of 26 elements in order to define the background levels in the region. The quantification was carried out by the sector field inductively coupled plasma mass spectrometry. No relevant temporal accumulation patterns between 2005 and 2006 sampling campaigns were observed. Then, the results were submitted to multivariate statistical analysis (cluster and principal component analyses). Cluster analysis produced a dendrogram where the 71 sites were divided into four clusters at (Dlink/Dmax)100Ushuaia-Road 3 (E area) and it was characterized by high levels of Cd, Co, Ni, Pb, Sb, and W in lichens. The present study has revealed the good capacity of U. barbata to reflect the baseline levels of elements in the environment at a regional scale level. The presence of certain level of elements in lichens agrees with the hypothesis that Tierra del Fuego is not a relatively pristine environment as occasionally supposed. However, when comparing our results with other countries, Tierra del Fuego lichens have a very low content of the measured elements. PMID:19232724

  18. Fate of a broad spectrum of perfluorinated compounds in soils and biota from Tierra del Fuego and Antarctica

    International Nuclear Information System (INIS)

    In this study, the presence of 18 perfluorinated compounds was investigated in biota and environmental samples from the Antarctica and Tierra de Fuego, which were collected during a sampling campaign carried out along February and March 2010. 61 samples were analysed including fish, superficial soils, guano, algae, dung and tissues of Papua penguin by liquid chromatography coupled to tandem mass spectrometry. The concentrations of PFCs were ranging from 0.10 to 240 ng/g for most of the samples except for penguin dung, which presented levels between 95 and 603 ng/g for perfluorooctane sulfonate, and guano samples from Ushuaia, with concentration levels of 1190–2480 ng/g of perfluorohexanoic acid. PFCs acids presented, in general, the highest levels of concentration and perfluorooctanesulfonate was the most frequently found compound. The present study provides a significant amount of results, which globally supports the previous studies, related to the transport, deposition, biodegradation and bioaccumulation patterns of PFCs. - Highlights: ► 61 samples from the Antarctica and Tierra de Fuego analysed for the presence of 18 perfluorinated compounds. ► Acid compounds presented the highest levels of concentration and perfluorooctane sulfonate was the most frequently found. ► Concentrations in algae much higher than those in soils. ► Data supporting existing models for the transport, deposition, biodegradation and bioaccumulation patterns are presented. - 18 perfluorinated compounds assessed in biota and environmental samples from Tierra del Fuego and the Antarctica. Concentrations related to Compounds properties.

  19. New Technologies to Improve Root Canal Disinfection.

    Science.gov (United States)

    Plotino, Gianluca; Cortese, Teresa; Grande, Nicola M; Leonardi, Denise P; Di Giorgio, Gianni; Testarelli, Luca; Gambarini, Gianluca

    2016-01-01

    Effective irrigant delivery and agitation are prerequisites to promote root canal disinfection and debris removal and improve successful endodontic treatment. This paper presents an overview of the currently available technologies to improve the cleaning of the endodontic space and their debridement efficacy. A PubMed electronic search was conducted with appropriate key words to identify the relevant literature on this topic. After retrieving the full-text articles, all the articles were reviewed and the most appropriate were included in this review. Several different systems of mechanical activation of irrigants to improve endodontic disinfection were analysed: manual agitation with gutta-percha cones, endodontic instruments or special brushes, vibrating systems activated by low-speed hand-pieces or by sonic or subsonic energy, use of ultrasonic or laser energy to mechanically activate the irrigants and apical negative pressure irrigation systems. Furthermore, this review aims to describe systems designed to improve the intracanal bacterial decontamination by a specific chemical action, such as ozone, direct laser action or light-activated disinfection. The ultrasonic activation of root canal irrigants and of sodium hypochlorite in particular still remains the gold standard to which all other systems of mechanical agitation analyzed in this article were compared. From this overview, it is evident that the use of different irrigation systems can provide several advantages in the clinical endodontic outcome and that integration of new technologies, coupled with enhanced techniques and materials, may help everyday clinical practice. PMID:27007337

  20. Visibility of the central canal on MRI

    Energy Technology Data Exchange (ETDEWEB)

    Petit-Lacour, M.C.; Lasjaunias, P.; Iffenecker, C.; Benoudiba, F.; Hadj Rabia, M.; Doyon, D. [Service de Neuroradiologie, Faculte de Paris Sud (France); Hurth, M. [Department of Neurosurgery, Faculte Paris Sud, Kremlin-Bicetre (France)

    2000-10-01

    The central canal of the spinal cord is present at birth and becomes progressively obliterated. Cadaver studies have shown that it may persiste partially or completely. To our knowledge, this entity has not been described on MRI. We reviewed 794 MRI studies of the spinal cord, and found 12 patients (aged 14 to 65 years) who had an intramedullary cavity. The cavity was at the junction of the ventral {sup 1}/{sub 3} and dorsal {sup 2}/{sub 3} of the spinal cord, except at the level of the lumbar enlargement, where it was central. It was filiform in most cases, although sometimes fusiform (3 to 4 mm in diameter), and had regular contours. The cavity were thoracic in 69 % of cases. The clinical features were totally unrelated to the image, and there were no anatomical factors (Chiari malformation, dysraphism) predisposing to syringomyelia. The images were perfectly compatible with a persistent central canal, which we interpret as a variant of normal anatomy. Therefore it is important to regard these findings as normal, to avoid unnecessary treatment and follow-up. (orig.)

  1. Anal canal carcinoma: Diagnosis - therapy - prognosis

    International Nuclear Information System (INIS)

    78 patients with anal canal carcinoma were treated between 1970 and 1988 at the University Hospital Erlangen. 48 patients (35 women, 13 men) were treated by surgery alone, 44/48 by abdominoperineal resection, 4/48 by local excision. Median age was 63 years, median follow-up 8.5 years. The overall local recurrence rate was 16.7%, the overall five-year-survival was 51%. 30 patients received a combined radio-chemotherapy. The small pelvis was treated with a.-p./p.-a. fields up to a total dose between 42 and 50 Gy. Two courses of chemotherapy consisting of 5-FU (800 to 1000 mg/m2 days 1 to 4 and 29 to 32) and Mitomycin C (10 mg/m2 days 1 and 29) were administered. Two months after completion of treatment 83% had a biopsy proven complete remission. After a median follow-up of 15 months 87% are alive with NED, 74% are continent. The combined regimen of radio-chemotherapy is considered as the treatment of the choice for anal canal carcinoma. Abdominoperineal resection is only performed in patients with non response or local recurrent disease. (orig.)

  2. Reform in Indian canal irrigation: does technology matter?

    NARCIS (Netherlands)

    Narain, V.

    2008-01-01

    This paper examines the implications of technology - the design of canal irrigation for irrigation management reform. With reference to two different design systems in Indian irrigation - shejpali and warabandi - it shows that the potential for reform varies with the design of canal irrigation. Thre

  3. RCRA closure of the Building 3001 Storage Canal

    International Nuclear Information System (INIS)

    The 3001 Storage Canal is located under portions of Buildings 3001 and 3019 at Oak Ridge National Laboratory (ORNL) and has a capacity of approximately 62,000 gallons of water. The term canal has historically been used to identify this structure, however, the canal is an in-ground reinforced concrete structure satisfying the regulatory definition of a tank. From 1943 through 1963, the canal in Building 3001 was designed to be an integral part of the system for handling irradiated fuel from the Oak Ridge Graphite Reactor. Because one of the main initial purposes of the reactor was to produce plutonium for the chemical processing pilot plant in Building 3019, the canal was designed to be the connecting link between the reactor and the pilot plant. During the war years, natural uranium slugs were irradiated in the reactor and then pushed out of the graphite matrix into the system of diversion plates and chutes which directed the fuel into the deep pit of the canal. After shutdown of the reactor, the canal was no longer needed for its designed purpose. Since 1964, the canal has only been used to store radioisotopes and irradiated samples under a water pool for radiation protection. This report describes closure alternatives

  4. 5 CFR 550.714 - Panama Canal Commission employees.

    Science.gov (United States)

    2010-01-01

    ...) Notwithstanding any other provisions of this subpart, an employee separated from employment with the Panama Canal... a position that meets all the following conditions: (1) The position is with the Panamanian public... below the employee's rate of basic pay as a Panama Canal Commission employee; (3) The position is...

  5. Convergence or reticulation? Mosaic evolution in the canalized American Amaryllidaceae

    Science.gov (United States)

    Canalization is defined as the suppression of phenotypic variation, or, in the context of molecular evolution, genetic buffering that has evolved under natural selection in order to stabilize the phenotype. Very little is understood on the processes behind canalization, even in today’s genomic era....

  6. Status of the interoceanic canal study

    International Nuclear Information System (INIS)

    The studies of Atlantic-Pacific Interoceanic Sea-Level Canal Study Commission are are not as yet completed, although there is no reason at this time to doubt that the 1 December 1970 deadline for the Commission's final report will be met. Since it has not been published, I am unable to pass on to you any of its conclusions; they simply do not exist today. And it would be improper for me to reveal the substance of the Commission's deliberations to date or to speculate upon what their outcome may be. But many elements of the work being conducted under my supervision - The Engineering Feasibility Study - are already in the public domain. It is to them that my remarks here are addressed. Of the six basic routes we have considered in our studies for possible sea-level canal alinements, four could involve nuclear excavating techniques. The so-called nuclear alternatives are Route 8 along the Nicaragua-Costa Rica border, Route 17 across the Darien Isthmus of Panama, Route 23 crossing the Panama-Colombia border and Route 25 across the western tip of Colombia. The conventionally excavated routes are Route 10 west of the Panama Canal Zone and Route 14 along the alinement of the present canal. The engineering studies examine from a technical standpoint the feasibility of constructing these routes and estimate their costs. To accomplish this we have made conceptual designs for canals capable of transiting at least 40,000 vessels annually (and possibly several times that many) and of accommodating ships of up to 250,000 dwt in size. Thus, in terms of basic requirements, all alternatives - conventional and nuclear - have been made comparable. Beginning with the northernmost route, let us now consider the four nuclear alternatives. Route 8 is 137 miles in length. Its maximum elevations are slightly less than 800 feet in the Continental Divide and about 400 feet through the so-called Eastern Divide. The rock to be excavated is primarily volcanic tuff. It is readily apparent that

  7. The Influence of Canalization on the Robustness of Boolean Networks

    CERN Document Server

    Kadelka, Claus; Laubenbacher, Reinhard

    2016-01-01

    Time- and state-discrete dynamical systems are frequently used to model molecular networks. This paper provides a collection of mathematical and computational tools for the study of robustness in Boolean network models. The focus is on networks governed by $k$-canalizing functions, a recently introduced class of Boolean functions that contains the well-studied class of nested canalizing functions. The activities and sensitivity of a function quantify the impact of input changes on the function output. This paper generalizes the latter concept to $c$-sensitivity and provides formulas for the activities and $c$-sensitivity of general $k$-canalizing functions as well as canalizing functions with more precisely defined structure. A popular measure for the robustness of a network, the Derrida value, can be expressed as a weighted sum of the $c$-sensitivities of the governing canalizing functions, and can also be calculated for a stochastic extension of Boolean networks. These findings provide a computationally eff...

  8. Apical pressures developed by needles for canal irrigation.

    Science.gov (United States)

    Bradford, C E; Eleazer, P D; Downs, K E; Scheetz, J P

    2002-04-01

    Drying instrumented canals with pressurized air may result in patient morbidity or even fatality. Low pressure and side vent needles have been suggested to lessen the danger. This study observed apical pressures from different needles inserted deeply into small round and ovoid canals as instrumentation progressed. Low-pressure (5 psi) air was injected through the needles, and apical pressures were recorded after each instrument. Pressures varied greatly within each test group. Generalities that can be drawn are that binding the needle within the canal gives higher pressures than with the needle slightly short of binding and that pressures were higher with apexes instrumented to size 30 and higher. With the needle tightly bound, neither needle size, needle design, nor canal shape resulted in statistically significant mean pressure differences. With the needle slightly withdrawn, larger bore needles gave higher pressures than small diameter needles. Caution is advised with the clinical use of pressurized air in the drying of root canals. PMID:12043877

  9. Direct solutions for normal depths in curved irrigation canals

    CERN Document Server

    Zhang, X Y

    2013-01-01

    The normal depth is an important hydraulic element for canal design, operation and management. Curved irrigation canals including parabola, U-shaped and catenary canals have excellent hydraulic performance and strong ability of anti-frost heave, while the normal depths in the governing equations of the current common methods have no explicit analytical solution. They are only indirect methods by using trial procedures, numerical methods, and graphical tools. This study presents new direct formulas for normal depth in curved irrigation canals by applying for Marquardt method. The maximum relative error of the proposed formulas is less than 1% within the practice range by comparative analysis, and they are simple and convenient for manual calculations. The results may provide the reliable theoretical basis and useful reference for the design and operation management of irrigation canals.

  10. Tierras de la microcuenca potrerillo (Cauca, Colombia: Clasificación local en relación con propiedades edáficas.

    Directory of Open Access Journals (Sweden)

    Cerón Rengifo Carmen Patricia

    2003-12-01

    Full Text Available Este estudio se realizó con el objetivo de relacionar la clasificación local de tierras con propiedades físicas, químicas y biológicas del suelo. Se hicieron entrevistas a 36 agricultores de la microcuenca, Potrerillo, Cauca, Colombia, para considerar criterios culturales de clasificación local; se tomaron muestras de suelo en 8 tierras, de 0 a 5 y 0 a 20 cm, con 5 repeticiones. Se determinó color, textura, N y P disponible, C total, fracción liviana de materia orgánica (LL, PH, Ca, K, Mg y Al. Los datos se trabajaron estadísticamente a partir de análisis de varianza, prueba Duncan y análisis de clasificación de datos. La información sugiere que los agricultores diferencias las tierras a partir de la ubicación, características físicas del suelo y de categorías culturales llamadas tierra buena, mala, brava y cansada. Las tierras consideradas buenas se relacionan con colores pardos oscuros, contenidos más altos de N, C y fracción LL, mayor densidad de miriápodos en tierras con vegetación arbórea y mayor biomasa de lombrices en barbecho de la parte baja de la colina. Entre las tierras de menor calidad, disminuye N, C fracción LL y Al y aumenta el pH; en aquellas que no son utilizadas son frecuentes los colores amarillos o rojos, decrecen los valores de N, C, LL, Ph y se incrementa el Al.

  11. Rock Magnetic Properties of Laguna Carmen (Tierra del Fuego, Argentina): Implications for Paleomagnetic Reconstruction

    Science.gov (United States)

    Gogorza, C. G.; Orgeira, M. J.; Ponce, F.; Fernández, M.; Laprida, C.; Coronato, A.

    2013-05-01

    We report preliminary results obtained from a multi-proxy analysis including paleomagnetic and rock-magnetic studies of two sediment cores of Laguna Carmen (53°40'60" S 68°19'0" W, ~83m asl) in the semiarid steppe in northern Tierra del Fuego island, Southernmost Patagonia, Argentina. Two short cores (115 cm) were sampled using a Livingstone piston corer during the 2011 southern fall. Sediments are massive green clays (115 to 70 cm depth) with irregularly spaced thin sandy strata and lens. Massive yellow clay with thin sandy strata continues up to 30 cm depth; from here up to 10 cm yellow massive clays domain. The topmost 10 cm are mixed yellow and green clays with fine sand. Measurements of intensity and directions of Natural Remanent Magnetization (NRM), magnetic susceptibility, isothermal remanent magnetization, saturation isothermal remanent magnetization (SIRM), back field and anhysteretic remanent magnetization at 100 mT (ARM100mT) were performed and several associated parameters calculated (ARM100mT/k and SIRM/ ARM100mT). Also, as a first estimate of relative magnetic grain-size variations, the median destructive field of the NRM (MDFNRM), was determined. Additionally, we present results of magnetic parameters measured with vibrating sample magnetometer (VSM). The stability of the NRM was analyzed by alternating field demagnetization. The magnetic properties have shown variable values, showing changes in both grain size and concentration of magnetic minerals. It was found that the main carrier of remanence is magnetite with the presence of hematite in very low percentages. This is the first paleomagnetic study performed in lakes located in the northern, semiarid fuegian steppe, where humid-dry cycles have been interpreted all along the Holocene from an aeolian paleosoil sequence (Orgeira et el, 2012). Comparison between paleomagnetic records of Laguna Carmen and results obtained in earlier studies carried out at Laguna Potrok Aike (Gogorza et al., 2012

  12. Basalto alcalino portador de xenolitos ultramáficos en Tierra del Fuego

    Directory of Open Access Journals (Sweden)

    R.D. Acevedo

    2004-09-01

    Full Text Available En el extremo sur de Tierra del Fuego han sido descubiertas rocas basáltico alcalinas con enclaves ultramáficos. Los pequeños cuerpos de basalto alcalino hasta aquí conocidos son escasos y las rocas circundantes están constituidas por pizarras pertenecientes a depósitos mesozoicos. La petrografía, textura y composición de los basaltos y xenolitos fue investigada con microscopio petrográfico y microsonda electrónica. Xenocristales de anfíbol y feldespato alcalino, olivina, espinelos, flogopita y minerales de Fe-Ti (10% y una diversidad de xenolitos (15%, principalmente lherzolíticos, piroxeníticos y wehrlíticos, pero también provenientes de rocas metamórficas, se encuentran inmersos en el basalto, cuya pasta está formada por tablillas y agujas de plagioclasa, piroxeno, minerales opacos, apatita y vidrio, con texturas intersertal, hialopilítica y pilotáxica. Hay amígdalas rellenas por analcita, ceolitas, sodalita y calcita. La clasificación normativa de esta roca, basada en su contenido nefelínico, es la de un basalto alcalino. La clasificación química, considerando la relación Zr/TiO2 frente a Nb/Y indica también un basalto alcalino y en el diagrama TAS los puntos caen en los campos de las foiditas (ricas en Na o nefelinitas y basanitas. Los diagramas de tierras raras muestran un alto grado de fraccionamiento (La/Yb~30. La datación isotópica de K-Ar sobre macrocristales da edades de 146±5 Ma (anfíbol y 127±4 Ma (feldespato alcalino y sobre roca total, 8,3±0,3 Ma. Sin embargo, las muestras fértiles denotan rasgos geoquímicos típicos de materiales de profundidad, lo que indicaría, basado en su posición tectónica actual, que el basalto es más antiguo que la edad isotópica obtenida.

  13. Apuntes para una historia de la insurgencia en la Tierra Caliente de Guerrero, 1810-1821

    Directory of Open Access Journals (Sweden)

    Jesús Guzmán Urióstegui

    2009-06-01

    Full Text Available Durante el periodo de lucha por la independencia de México, de 1810 a 1821, una de las zonas geográficas más destacadas por su apoyo a la insurgencia fue la del Sur, cuyo territorio forma actualmente el estado de Guerrero. Primero con José María Morelos y Pavón y luego con Vicente Guerrero, la complicada geografía suriana y su no menos malsano clima puso en entredicho todos los intentos de las autoridades virreinales por reestablecer ahí la paz. Es cierto que los realistas lograron algunos éxitos, pero nunca pudieron vencer los afanes de libertad de los pobladores del lugar, especialmente de los de Tierra Caliente, mismos que si bien de 1811 a 1813 actuaron de manera en cierta forma aislada, pues Morelos no los tomaba muy en cuenta ya que prefería a los costeños, después fueron su sostén principal. Este papel lo refrendarían de igual manera de 1816 a 1821 con Guerrero, obligando a Agustín de Iturbide a negociar la paz.During Mexico's struggle for independence, from 1810 to 1821, one of the geographical zones that provided most support for the insurgents was the south, whose territory currently forms part of the state of Guerrero. First with José María Morelos y Pavón and then with Vicente Guerrero, the complicated geography of the south and its no less unhealthy climate jeopardized all the viceregal authorities' attempts to re-establish peace there. Although the royalists had some success, they were never able to overcome the locals' desire for freedom, especially those in Tierra Caliente. Although they acted in a somewhat isolated fashion from 1811 to 1813, since Morelos ignored them, preferring those on the coast, they subsequently provided his greatest support. They did the same with Guerrero from 1816 to 1821, forcing Agustín de Iturbide to negotiate peace.

  14. Carcinogenesis and Inflammatory Effects of Plutonium-Nitrate Retention in an Exposed Nuclear Worker and Beagle Dogs.

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, Christopher E. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Wang, Xihai [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Robinson, Robert J. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Brooks, Antone L. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Lovaglio, Jamie A. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Patton, Kristin M. [Battelle Toxicology Northwest, Richland, WA (United States); McComish, Stacey [United States Transuranium and Uranium Registries, Washington State University, College of Pharmacy, Richland, WA (United States); Tolmachev, Sergei Y. [United States Transuranium and Uranium Registries, Washington State University, College of Pharmacy, Richland, WA (United States); Morgan, William F. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

    2014-01-01

    The genetic and inflammatory response pathways elicited following plutonium exposure in archival lung tissue of an occupationally exposed human and experimentally exposed beagle dogs were investigated. These pathways include: tissue injury, apoptosis and gene expression modifications related to carcinogenesis and inflammation. In order to determine which pathways are involved, multiple lung samples from a plutonium exposed worker (Case 0269), a human control (Case 0385), and plutonium exposed beagle dogs were examined using histological staining and immunohistochemistry. Examinations were performed to identify target tissues at risk of radiation-induced fibrosis, inflammation, and carcinogenesis. Case 0269 showed interstitial fibrosis in peripheral and subpleural regions of the lung, but no pulmonary tumors. In contrast, the dogs with similar and higher doses showed pulmonary tumors primarily in brochiolo-alveolar, peripheral and subpleural alveolar regions. The TUNEL assay showed slight elevation of apoptosis in tracheal mucosa, tumor cells, and nuclear debris was present in the inflammatory regions of alveoli and lymph nodes of both the human and the dogs. The expression of apoptosis and a number of chemokine/cytokine genes was slightly but not significantly elevated in protein or gene levels compared to that of the control samples. In the beagles, mucous production was increased in the airway epithelial goblet cells and glands of trachea, and a number of chemokine/cytokine genes showed positive immunoreactivity. This analysis of archival tissue from an accidentally exposed worker and in a large animal model provides valuable information on the effects of long-term retention of plutonium in the respiratory tract and the histological evaluation study may impact mechanistic studies of radiation carcinogenesis.

  15. Carcinogenesis and Inflammatory Effects of Plutonium-Nitrate Retention in an Exposed Nuclear Worker and Beagle Dogs

    International Nuclear Information System (INIS)

    The genetic and inflammatory response pathways elicited following plutonium exposure in archival lung tissue of an occupationally exposed human and experimentally exposed beagle dogs were investigated. These pathways include: tissue injury, apoptosis and gene expression modifications related to carcinogenesis and inflammation. In order to determine which pathways are involved, multiple lung samples from a plutonium exposed worker (Case 0269), a human control (Case 0385), and plutonium exposed beagle dogs were examined using histological staining and immunohistochemistry. Examinations were performed to identify target tissues at risk of radiation-induced fibrosis, inflammation, and carcinogenesis. Case 0269 showed interstitial fibrosis in peripheral and subpleural regions of the lung, but no pulmonary tumors. In contrast, the dogs with similar and higher doses showed pulmonary tumors primarily in brochiolo-alveolar, peripheral and subpleural alveolar regions. The TUNEL assay showed slight elevation of apoptosis in tracheal mucosa, tumor cells, and nuclear debris was present in the inflammatory regions of alveoli and lymph nodes of both the human and the dogs. The expression of apoptosis and a number of chemokine/cytokine genes was slightly but not significantly elevated in protein or gene levels compared to that of the control samples. In the beagles, mucous production was increased in the airway epithelial goblet cells and glands of trachea, and a number of chemokine/cytokine genes showed positive immunoreactivity. This analysis of archival tissue from an accidentally exposed worker and in a large animal model provides valuable information on the effects of long-term retention of plutonium in the respiratory tract and the histological evaluation study may impact mechanistic studies of radiation carcinogenesis

  16. Bovine Colostral Antibody Against Verotoxin 2 Derived from Escherichia coli O157:H7: Resistance to Proteases and Effects in Beagle Dogs

    OpenAIRE

    Kuribayashi, Takashi; Seita, Tetsuro; Matsumoto, Mariko; Furuhata, Katsunori; Tagata, Kazutoshi; Yamamoto, Shizuo

    2009-01-01

    A bovine colostral antibody against verotoxin (VT) 2 of Escherichia coli O157:H7 was administered orally to beagle dogs. The antibody remained in the dogs’ small intestine for at least 2 h, whereas little serum antibody remained 1.5 h after administration. Furthermore, the antibody activity of secretory IgA did not change until 2 h after administration; however, the activity of IgG and IgM antibodies decreased by approximately 60% and 40% at 2 h after administration, respectively. Seven beagl...

  17. Chov psů plemene beagle v ČR a některé etologické aspekty reprodukce

    OpenAIRE

    Šabatová, Jitka

    2013-01-01

    Beagle is one of favourite dog breeds in the world. Beagle is bred in the Czech Republic for only 20 years but despite this fact it became very popular not only as hunting breed but mainly as family breed. Reproduction of bred animal is for breeders one of the most important function of the organism. Ethological aspects of dogs´ reproduction are related to successful breeding. Dog has been domesticated for very long time, despite this fact its social behaviour has not changed n...

  18. Dynamics of Alloplastic Bone Grafts on an Early Stage of Corticotomy-Facilitated Orthodontic Tooth Movement in Beagle Dogs

    Directory of Open Access Journals (Sweden)

    Hyung-Joo Choi

    2014-01-01

    Full Text Available Alveolar augmented corticotomy is effective in accelerating orthodontic tooth movement, but the effect only lasts for a relatively short time. Therefore, the purpose of this study was to investigate the underlying biology of the immediate periodontal response to orthodontic tooth movement after a corticotomy with alloplastic bone grafts. The results demonstrated that measurable tooth movement began as early as 3 days after the intervention in beagle dogs. Based on the results and histological findings, augmented corticotomy-facilitated orthodontic tooth movement might enhance the condition of the periodontal tissue and the stability of the outcomes of orthodontic treatment.

  19. Dynamics of alloplastic bone grafts on an early stage of corticotomy-facilitated orthodontic tooth movement in beagle dogs.

    Science.gov (United States)

    Choi, Hyung-Joo; Lee, Dong-Yeol; Kim, Tae-Woo

    2014-01-01

    Alveolar augmented corticotomy is effective in accelerating orthodontic tooth movement, but the effect only lasts for a relatively short time. Therefore, the purpose of this study was to investigate the underlying biology of the immediate periodontal response to orthodontic tooth movement after a corticotomy with alloplastic bone grafts. The results demonstrated that measurable tooth movement began as early as 3 days after the intervention in beagle dogs. Based on the results and histological findings, augmented corticotomy-facilitated orthodontic tooth movement might enhance the condition of the periodontal tissue and the stability of the outcomes of orthodontic treatment. PMID:25276787

  20. Study of bone formation in the mandibular alveolar process of the young adult beagle by tetracycline label analysis

    International Nuclear Information System (INIS)

    The mandibular alveolar processes of young, adult beagles were observed to determine several aspects of tissue-level bone turnover. The animals had been previously labeled with a double tetracycline (TC) regimen, and analysis carried out on the resulting label distributions and patterns. Analysis of the fraction of bone surface incorporating TC showed that about 1.5 percent of surfaces are double labeled, 16 percent are single labeled, and 75 percent of surfaces are bare of label. The apposition rate for formation sites was found to be approximately 1.54 μm/day