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Sample records for canada prevalence drugs

  1. Drug problems among homeless individuals in Toronto, Canada: prevalence, drugs of choice, and relation to health status

    Directory of Open Access Journals (Sweden)

    Kiss Alex

    2010-02-01

    Full Text Available Abstract Background Drug use is believed to be an important factor contributing to the poor health and increased mortality risk that has been widely observed among homeless individuals. The objective of this study was to determine the prevalence and characteristics of drug use among a representative sample of homeless individuals and to examine the association between drug problems and physical and mental health status. Methods Recruitment of 603 single men, 304 single women, and 284 adults with dependent children occurred at homeless shelters and meal programs in Toronto, Canada. Information was collected on demographic characteristics and patterns of drug use. The Addiction Severity Index was used to assess whether participants suffered from drug problems. Associations of drug problems with physical and mental health status (measured by the SF-12 scale were examined using regression analyses. Results Forty percent of the study sample had drug problems in the last 30 days. These individuals were more likely to be single men and less educated than those without drug problems. They were also more likely to have become homeless at a younger age (mean 24.8 vs. 30.9 years and for a longer duration (mean 4.8 vs. 2.9 years. Marijuana and cocaine were the most frequently used drugs in the past two years (40% and 27%, respectively. Drug problems within the last 30 days were associated with significantly poorer mental health status (-4.9 points, 95% CI -6.5 to -3.2 but not with poorer physical health status (-0.03 points, 95% CI -1.3 to 1.3. Conclusions Drug use is common among homeless individuals in Toronto. Current drug problems are associated with poorer mental health status but not with poorer physical health status.

  2. Estimating the prevalence of infertility in Canada

    OpenAIRE

    Bushnik, Tracey; Cook, Jocelynn L.; Yuzpe, A. Albert; Tough, Suzanne; Collins, John

    2013-01-01

    BACKGROUND Over the past 10 years, there has been a significant increase in the use of assisted reproductive technologies in Canada, however, little is known about the overall prevalence of infertility in the population. The purpose of the present study was to estimate the prevalence of current infertility in Canada according to three definitions of the risk of conception. METHODS Data from the infertility component of the 2009–2010 Canadian Community Health Survey were analyzed for married a...

  3. Five prevalent antiprotozoal herbal drugs

    Directory of Open Access Journals (Sweden)

    Mohammad Azadbakht1

    2008-01-01

    Full Text Available , (Received 21 Jun, 2008 ; Accepted 12 Nov, 2008 AbstractAccording to the statistics provided by the World Health Organization (WHO, about 80% of the world population nowadays uses herbal drugs for treatment of diseases. Natural products obtained from medicinal plants, serve as a great source for drug production and are the main basis of new drug compounds. Unicellular organisms (Protozoa are the cause of deaths and spread of diseases in various societies, especially in developing countries. There are anti-malaria herbal dugs produced from various medicinal plants, some of which are used for treatment of the disease and some under study. The first anti-malaria drug was quinine, produced from bark of the Cinchona tree. Recently, the drug artemisinin has been introduced by Chinese scientists for the treatment of malaria and is currently used extensively. Coetaneous leishmaniosis (salak is one of the endemic diseases in most parts of Iran. Common drugs used against leishmaniosis (such as glucantim, have severe side-effects and in 10 to 25% of cases, there is a recurrence of the disease. Emetine is one of the drugs obtained from a root of the plant Ipecac, which is used for treatment of the disease sub-cutaneously. Giardiasis is an acute protozoan infection usually with no clinical symptoms, however, may appear as acute or chronic diarrhea. According to the announcement of WHO, more than 2/3 of the world’s population is infected with intestinal parasites and the prevalence of giardia is higher than other intestinal parasites. Herbal drugs, such as wild garlic, eucalyptus and thyme, are some of the major plants which can annihilate the giarda cysts. Annually, 75000 to 100000 people die of amebiasis (dysentery worldwide. Due to the motility of the organism, it causes sever pathological changes and sometimes colon ulcers, and if entered into the blood stream, it may appear as liver or brain abscess. Medicinal plants such as ipecac, mango, and papaya

  4. Prevalence of weather sensitivity in Germany and Canada

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    Mackensen, Sylvia; Hoeppe, Peter; Maarouf, Abdel; Tourigny, Pierre; Nowak, Dennis

    2005-01-01

    Several studies have shown that atmospheric conditions can affect well-being or disease, and that some individuals seem to be more sensitive to weather than others. Since epidemiological data on the prevalence of weather-related health effects are lacking, two representative weather sensitivity (WS) surveys were conducted independently in Germany and Canada. The objectives of this paper are: (1) to identify the prevalence of WS in Germany and Canada, (2) to describe weather-related symptoms and the corresponding weather conditions, and (3) to compare the findings in the two countries. In Germany 1,064 citizens (age >16 years) were interviewed in January 2001, and in Canada 1,506 persons (age >18 years) were interviewed in January 1994. The results showed that 19.2% of the German population thought that weather affected their health “to a strong degree,” 35.3% that weather had “some influence on their health” (sum of both = 54.5% weather sensitive), whereas the remaining 45.5% did not consider that weather had an effect on their health status. In Canada 61% of the respondents considered themselves to be sensitive to the weather. The highest prevalence of WS (high + some influence) in Germans was found in the age group older than 60 years (68%), which was almost identical in the Canadian population (69%). The highest frequencies of weather-related symptoms were reported in Germany for stormy weather (30%) and when it became colder (29%). In Canada mainly cold weather (46%), dampness (21%) and rain (20%) were considered to affect health more than other weather types. The most frequent symptoms reported in Germany were headache/migraine (61%), lethargy (47%), sleep disturbances (46%), fatigue (42%), joint pain (40%), irritation (31%), depression (27%), vertigo (26%), concentration problems (26%) and scar pain (23%). Canadian weather-sensitive persons reported colds (29%), psychological effects (28%) and painful joints, muscles or arthritis (10%). In Germany 32

  5. Five prevalent antiprotozoal herbal drugs

    OpenAIRE

    Mohammad Azadbakht; Masoud Azadbakht2

    2008-01-01

    , (Received 21 Jun, 2008 ; Accepted 12 Nov, 2008) AbstractAccording to the statistics provided by the World Health Organization (WHO), about 80% of the world population nowadays uses herbal drugs for treatment of diseases. Natural products obtained from medicinal plants, serve as a great source for drug production and are the main basis of new drug compounds. Unicellular organisms (Protozoa) are the cause of deaths and sp...

  6. Acetylsalicylic-acid-containing drugs and nonsteroidal anti-inflammatory drugs available in Canada

    OpenAIRE

    Brigden, M; Smith, R E

    1997-01-01

    A large number of drugs containing acetylsalicylic acid (ASA) and nonsteroidal anti-inflammatory drugs (NSAIDs) are available by prescription and over the counter in Canada. The possibility of serious side effects and drug interactions is therefore high. The authors have compiled a comprehensive list of products containing these drugs from information supplied by pharmaceutical databases, independent marketing researchers and Health Canada's Drug Directorate. Physicians should ensure that add...

  7. Mode shifting in school travel mode: examining the prevalence and correlates of active school transport in Ontario, Canada

    OpenAIRE

    Buliung Ron; Faulkner Guy; Wong Bonny Yee-Man; Irving Hyacinth

    2011-01-01

    Abstract Background Studies examining the correlates of school transport commonly fail to make the distinction between morning and afternoon school trips. The purpose of this study was to examine the prevalence and correlates of mode shift from passive in the morning to active in the afternoon among elementary and secondary school students in Ontario, Canada. Methods Data were derived from the 2009 cycle of the Ontario Student Drug Use and Health Survey (OSDUHS). 3,633 students in grades 7 th...

  8. Compulsory drug treatment in Canada: historical origins and recent developments.

    Science.gov (United States)

    Fischer, Benedikt; Roberts, Julian V; Kirst, Maritt

    2002-04-01

    In Canada, illicit drug use and addiction have traditionally been considered as a criminal justice problem and have been addressed from a legal perspective. Over the past century, a medical approach to drug addiction has slowly crept into the criminal justice processing of drug offenders. This has happened through the combination of principles of punishment with principles of addiction treatment in the sentencing of drug offenders to create a distinct application of 'compulsory drug treatment' in Canada. However, this evolution has occurred sporadically over time, with punishment and coercion as predominantly the main approach to dealing with this population. This evolution has recently culminated in Canada with the development of two criminal justice approaches to dealing with the substance use problems of drug offenders that incorporate concepts of punishment and treatment more equally than ever before - conditional sentencing and drug courts. This paper outlines the historical evolution of concepts of 'compulsory treatment', discusses such examples of contemporary 'compulsory treatment' as conditional sentencing and drug courts, and analyses the implications, concerns and challenges associated with these tools currently used in the sentencing of drug offenders in the Canadian context. PMID:11979008

  9. Distributional effects of `general population' prescription drug programs in Canada

    OpenAIRE

    Sule Alan; Thomas Crossley; Paul Grootendorst; Michael Veall

    2005-01-01

    Canadian household prescription drug expenditures are studied using the Statistics Canada Family Expenditure Survey masterfiles for periods that include the introduction of provincial `general population' prescription drug programs. Budget shares for non-senior households are examined over time using non-parametric regression, parametric `difference-in-difference' techniques, and quantile regression methods. The evidence suggests that while program effects are muted when there are high deduct...

  10. Prevalence of feline blood groups in the Montreal area of Quebec, Canada

    OpenAIRE

    Fosset, Fabrice T.J.; Blais, Marie-Claude

    2014-01-01

    The feline AB blood group system has clinical significance because type B cats have natural alloimmune anti-A antibodies which can cause isoerythrolysis of the newborn and life-threatening transfusion reactions. In the United States, the prevalence of type B blood is estimated to be 1% to 2%. This study determined the prevalence of feline AB blood groups among 207 potential blood donor cats that included 178 domestic cats, in the Montreal area of Quebec, Canada. Blood typing was performed usi...

  11. Income adequacy and education associated with the prevalence of obesity in rural Saskatchewan, Canada

    OpenAIRE

    Chen, Yue; Rennie, Donna C.; Chandima P. Karunanayake; Janzen, Bonnie; Hagel, Louise; Pickett, William; Dyck, Roland; Lawson, Joshua; Dosman, James A; Pahwa, Punam; ,

    2015-01-01

    Background Obesity is prevalent in rural communities in Canada, however little is known about the social determinants of health and obesity in rural populations. Socioeconomic status has been found to be inversely associated with the risk of obesity in developed countries. This study investigated the relationship between income adequacy, education and obesity in a rural setting. Methods The study used data from 5391 adults aged 18–69 who participated in the Saskatchewan Rural Health Study in ...

  12. Prevalence of antibodies to Leptospira in wild mammals trapped on livestock farms in Ontario, Canada.

    Science.gov (United States)

    Allen, Samantha E; Ojkic, Davor; Jardine, Claire M

    2014-07-01

    To determine the prevalence and diversity of Leptospira serogroups circulating in wildlife on farms in Ontario, we tested samples from 51 raccoons (Procyon lotor), seven skunks (Mephitis mephitis), four rats (Rattus norvegicus), and three opossums (Didelphis virginiana) that were trapped on 27 livestock (swine [Sus scrofa], cattle [Bos taurus]) farms in 2010. Seventeen of 51 raccoons (33%; 95% confidence interval [CI], 21-48%) sampled were positive for at least one Leptospira serogroup using the microscopic agglutination test. None of the other 14 animals had detectable Leptospira antibodies. On swine farms, 13 of 30 raccoons (43%; 95% CI, 27-61%) were antibody positive, and on cattle farms, four of 21 raccoons (19%; 95% CI, 8-40%) were positive. Leptospira antibody prevalence in raccoons did not differ between swine and cattle farms. Raccoons were positive to serovars representative of serogroups Grippotyphosa, Australis, Icterohaemorrhagiae, and Pomona and were negative to serovars of serogroups Autumnalis, Canicola, and Sejroe. The prevalence of Leptospira antibodies in raccoons in this study is similar to what has been reported previously; however, the diversity of serogroups was higher in this study than what has been reported in raccoons from an urban area of Ontario, Canada. Understanding the prevalence and distribution of Leptospira serogroups in wildlife in Ontario, Canada, is important for the development and maintenance of appropriate disease management strategies in humans, livestock, and companion animals. PMID:24807356

  13. Current trends in the prevalence of Cryptococcus gattii in the United States and Canada

    Directory of Open Access Journals (Sweden)

    Espinel-Ingroff A

    2015-05-01

    Full Text Available Ana Espinel-Ingroff,1 Sarah E Kidd21VCU Medical Center, Richmond, VA, USA; 2National Mycology Reference Center, SA Pathology, Adelaide, SA, AustraliaAbstract: The incidence of Cryptococcus gattii infections in both Canada and the United States (US is provided in this literature review beyond the British Columbia (BC outbreak (1999–2013. Based on a search of the literature, case reports of C. gattii human infections including the prevalent molecular genotypes causing these infections in both Canada and the US have been documented since the C. gattii outbreak in BC. The literature reveals that: i although C. gattii infections continue to be reported in both countries, the preliminary overall number of confirmed C. gattii infections may be decreasing in both Canada and the US (~23 cases each in 2012 versus ~17 and 20 cases, respectively in 2013; ii C. gattii genotype distribution is region-dependent; iii C. gattii is more frequently isolated from infections in the immunocompromised host (including acquired immune deficiency syndrome [AIDS] infection than previously expected; iv although pulmonary disease is higher than in C. neoformans infections, central nervous system disease is also reported among patients infected with C. gattii.Keywords: C. gattii, human infections, incidence, molecular epidemiology, United States, Canada 

  14. Prevalence of Rickettsia species in Dermacentor variabilis ticks from Ontario, Canada.

    Science.gov (United States)

    Wood, Heidi; Dillon, Liz; Patel, Samir N; Ralevski, Filip

    2016-07-01

    Relatively little is known about the prevalence of rickettsial species in Dermacentor ticks in eastern Canada. In this study, Dermacentor ticks from the province of Ontario, Canada, were tested for the presence of spotted fever group rickettsial (SFGR) species, Coxiella burnetii and Francisella tularensis. Rickettsia rickettsii was not detected in any ticks tested, but R. montanensis was detected at a prevalence of 2.2% in D. variabilis (17/778). Two other SFGR species, R. parkeri and Candidatus R. andeanae, were detected individually in 2 Amblyomma maculatum ticks. Rickettsia peacockii, a non-pathogenic endosymbiont, was detected in two D. andersonii ticks. Given the highly abundant nature of D. variabilis, surveillance for human pathogens in this species of tick has important public health implications, but the lack of detection of known human pathogens indicates a low risk of infection via this tick species in Ontario. However, the detection of R. parkeri in an adventive A. maculatum tick indicates that health care providers should be aware of the possibility of spotted fever rickettsioses in individuals with a history of travel outside of Ontario and symptoms compatible with a spotted fever rickettsiosis. Coxiella burnetii and Francisella tularensis, human pathogens also potentially transmitted by D. variabilis, were not detected in a subset of the ticks. PMID:27318438

  15. The Association Between Community Stressors and Asthma Prevalence of School Children in Winnipeg, Canada

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    Anita L. Kozyrskyj

    2012-02-01

    Full Text Available It is generally surmised that community stressors have an incubating effect for a variety of diagnoses on maternal and child health. This is of public health significance, as children of mothers facing long-term distress were found to have a 60% higher risk for asthma diagnosis at age 7 in Manitoba, Canada. Our objective was to determine the association of community stressors with childhood asthma prevalence in Winnipeg, Canada from participants who completed the Study of Asthma, Genes and the Environment (SAGE survey administered in 2002–2003 to a birth cohort from 1995. Measures of community socioeconomic makeup and community disorder with rank ordinalized by quintile at the census tract level were obtained from the 1996 Canada Census. Crime data (annual incidence per 10,000 persons by neighbourhood profile for 2001 was provided by the Winnipeg Police Service. Dichotomous caregiver report of child asthma along with other indicators from the geocoded SAGE survey allowed linkage to 23 neighbourhood profiles. Multilevel logistic regression analyses were performed to estimate the effect of community stressors on childhood asthma prevalence for birth and non-birth home children (N = 1472 and children resident of birth homes at age 7 or 8 (N = 698. After adjusting for individual risk factors, children resident of birth homes in a high thefts over $5,000 neighbourhood profile were twice as likely (Adjusted OR, 2.05; 95% CI, 1.11–3.81 to have report of asthma compared to children in a lower thefts over $5,000 profile, with community thefts over $5,000 explaining over half of the observed neighbourhood variation in asthma.

  16. Drug injection and HIV prevalence in inmates of Glenochil prison.

    OpenAIRE

    Gore, S M; Bird, A G; Burns, S M; Goldberg, D J; Ross, A.J.; MacGregor, J

    1995-01-01

    OBJECTIVE--To determine prevalence of HIV infection and drug injecting behaviour among inmates of Glenochil Prison on a specified date a year after an outbreak of hepatitis B and HIV infection. DESIGN--Cross sectional: voluntary, anonymous HIV salivary antibody surveillance and linked self completion questionnaire on risk factors. SETTING--Glenochil prison, Scotland, a year after an outbreak of hepatitis B and HIV transmission related to drug injection. SUBJECTS--352 prisoners, of whom 295 (8...

  17. Mode shifting in school travel mode: examining the prevalence and correlates of active school transport in Ontario, Canada

    Directory of Open Access Journals (Sweden)

    Buliung Ron

    2011-08-01

    Full Text Available Abstract Background Studies examining the correlates of school transport commonly fail to make the distinction between morning and afternoon school trips. The purpose of this study was to examine the prevalence and correlates of mode shift from passive in the morning to active in the afternoon among elementary and secondary school students in Ontario, Canada. Methods Data were derived from the 2009 cycle of the Ontario Student Drug Use and Health Survey (OSDUHS. 3,633 students in grades 7 through 12 completed self-administered questionnaires. Socio-demographic, behavioural, psychological, and environmental predictors of active school transport (AST were assessed using logistic regression. Results Overall, 47% and 38% of elementary school students reported AST to and from school, respectively. The corresponding figures were 23% and 32% for secondary school students. The prevalence of AST varied temporarily and spatially. There was a higher prevalence of walking/biking found for elementary school students than for secondary school students, and there was an approximate 10% increase in AST in the afternoon. Different correlates of active school transport were also found across elementary and secondary school students. For all ages, students living in urban areas, with a shorter travel time between home and school, and having some input to the decision making process, were more likely to walk to and from school. Conclusions Future research examining AST should continue to make the analytic distinction between the morning and afternoon trip, and control for the moderating effect of age and geography in predicting mode choice. In terms of practice, these variations highlight the need for school-specific travel plans rather than 'one size fits all' interventions in promoting active school transport.

  18. Canada

    International Nuclear Information System (INIS)

    Canada ranks ninth in the world in anthropogenic carbon dioxide emissions. Canada currently releases 1.9 percent of global carbon dioxide emissions from combustion of fossil fuels, production and treatment of oil and natural gas, and cement manufacturing. Canadian carbon dioxide emissions doubled between 1956 and 1986, growing at an average rate of about 2.4 percent per year. They reached a peak in 1979 and have since fluctuated within 10 percent of that amount. Despite the significant increase in emissions, Canada's share of global carbon dioxide emissions has declined slightly since 1956. On a per capita basis, Canada ranks fourth among nations in carbon dioxide emissions, with about 4.1 tons in 1986. This rate compares with the U.S. average of 5 tons per capita emissions have grown by about 25 percent since 1956. Canada, though a relatively small source of greenhouse gases, has been deeply involved in finding ways to reduce the risk of climatic change. The nation fortunately possesses opportunities to reduce this risk by saving energy, developing nonfossil energy resources, and facilitating international cooperation for capturing these opportunities worldwide

  19. Second-Hand Smoke Exposure in Canada: Prevalence, Risk Factors, and Association with Respiratory And Cardiovascular Diseases

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    Nicholas Vozoris

    2008-01-01

    Full Text Available OBJECTIVES: The aims of the present study were to estimate the prevalence of second-hand smoke exposure in Canada, to identify sociodemographic risk factors for second-hand smoke exposure, and to examine the relationship between second-hand smoke exposure and respiratory and cardiovascular diseases.

  20. A Profile of Substance Abuse, Gender, Crime, and Drug Policy in the United States and Canada

    Science.gov (United States)

    Grant, Judith

    2009-01-01

    The climate of domestic drug policy in the United States as it pertains to both women and men at the beginning of the 21st century is the criminalization mode of regulation--a mode that is based on the model of addiction as a crime and one that is used to prohibit the use of illegal drugs. In Canada, drug policy is based mainly on the harm…

  1. Buying and Selling Prescription Drugs on the Internet: Canada-United States Trade

    OpenAIRE

    Phillip Rosson

    2004-01-01

    In recent years, Internet pharmacies have emerged in Canada, primarily to supply US customers with lower-cost drugs. The pharmacies use e-commerce and other technologies to reach large numbers of potential customers and to exploit the sizeable price difference that exists for prescription drugs in the two countries. The resulting cross-border trade in drugs grew rapidly from 2001.2 Despite rapid, short-term success, the survival of Internet pharmacies was not assured. Critics of Internet phar...

  2. Prevalence of feline blood groups in the Montreal area of Quebec, Canada.

    Science.gov (United States)

    Fosset, Fabrice T J; Blais, Marie-Claude

    2014-01-01

    The feline AB blood group system has clinical significance because type B cats have natural alloimmune anti-A antibodies which can cause isoerythrolysis of the newborn and life-threatening transfusion reactions. In the United States, the prevalence of type B blood is estimated to be 1% to 2%. This study determined the prevalence of feline AB blood groups among 207 potential blood donor cats that included 178 domestic cats, in the Montreal area of Quebec, Canada. Blood typing was performed using a standardized tube technique. Blood types AB and B were confirmed using a backtyping technique. The frequency of blood types among the studied population was as follows: 95.2% type A, 4.4% type B, and 0.48% type AB. Among domestic cats, the frequency was 94.4% for type A, 5% for type B, and 0.6% for type AB. The frequency of type B was higher than expected, which reinforces the recommendation to ensure blood compatibility of the recipient and donor before transfusion through typing and possibly cross-matching as well. PMID:24381340

  3. Canada

    International Nuclear Information System (INIS)

    Nuclear research and development in Canada started in the 1940s as a responsibility of the federal government. An engineering design team was established at Chalk River, Ontario, to carry out research on heavy water moderated lattices. A zero-energy heavy water moderated research reactor, ZEEP, was built and achieved criticality in September 1945; it was in fact the first human-made operating reactor outside the USA. In 1947, the 20 MW heavy water moderated national research experimental reactor (NRX) started up. It served as one of the most valuable research reactors in the world, and provided the basis for Canada's development of the very successful CANDU series of pressurised heavy water reactors (PHWR) for power generation. Atomic Energy of Canada Limited (AECL) was established in 1952 as a federal Crown Corporation. It has both a public and a commercial mandate. AECL has overall responsibility for Canada's nuclear research and development programme (its public mandate) as well as for the Canadian reactor design (CANDU), engineering and marketing programme (its commercial mandate). Nuclear energy in Canada is a $5 billion per-year industry, representing about 150 firms, 21 000 direct jobs and 10 000 indirect jobs, and ∼$1.2 billion in exports - the value to the country's economy is much higher than the research and development funding provided by the federal government. The CANDU nuclear reactor system was developed by AECL in close collaboration with the Canadian nuclear industry, and in particular with Ontario Hydro (now Ontario Power Generation). Currently, Canada operates 17 CANDU reactors, which contribute 16% of the country's current electricity consumption. There are also 12 CANDU reactors operating abroad (in Argentina, China, India, the Republic of Korea, Pakistan and Romania). AECL is now developing the 'third generation plus' Advanced CANDU Reactor (ACR-1000), and also has the leading role internationally in developing the Generation IV

  4. Prevalence and Correlates of Drug-drug Interactions in the Regional Hospital of Gjilan, Kosovo

    Science.gov (United States)

    Shabani, Driton; Tahiri, Zejdush; Bara, Petrit; Hudhra, Klejda; Malaj, Ledian; Jucja, Besnik; Bozalia, Adnan; Burazeri, Genc

    2014-01-01

    Aim: Our aim was to assess the prevalence and socioeconomic and clinical correlates of drug-drug interactions among the adult population of transitional Kosovo. Methods: A cross-sectional study was conducted including a representative sample of 1921 patients aged ≥18 years (mean age: 57.8±11.2 years; 50.3% women; overall response: 96%) from the regional hospital of Gjilan, Kosovo, during 2011-2013. Potential drug-drug-interactions were assessed and clinical data as well as demographic and socioeconomic information were collected. Binary logistic regression was used to assess the correlates of drug-drug interactions. Results: Upon multivariable adjustment for all the demographic and socioeconomic factors as well as the clinical characteristics, drug-drug interactions were positively and significantly related to older age (OR=2.1, 95%CI=1.3-2.8), a lower educational attainment (OR=1.4, 95%CI=1.1-1.9), a longer hospitalization period (OR=2.7, 95%CI=2.1-3.6), presence of three groups of diseases [infectious diseases (OR=1.7, 95%CI=1.3-2.4), cardiovascular diseases (OR=1.8, 95%CI=1.4-2.6), respiratory diseases (OR=1.6, 95%CI=1.2-2.5)], presence of comorbid conditions (OR=3.2, 95%CI=2.3-4.4) and an intake of at least four drugs (OR=5.9, 95%CI=4.6-7.1). Conclusions: Our study provides important evidence on the prevalence and socioeconomic and clinical correlates of drug-drug interactions among the hospitalized patients in the regional hospital of Gjilan, Kosovo. Findings from our study should raise the awareness of decision-makers and policy makers about the prevalence and determinants of drug-drug interactions in the adult population of post-war Kosovo. PMID:25395892

  5. Second-hand smoke exposure in Canada: Prevalence, risk factors, and association with respiratory and cardiovascular diseases

    OpenAIRE

    Nicholas Vozoris; M Diane Lougheed

    2008-01-01

    OBJECTIVES: The aims of the present study were to estimate the prevalence of second-hand smoke exposure in Canada, to identify sociodemographic risk factors for second-hand smoke exposure, and to examine the relationship between second-hand smoke exposure and respiratory and cardiovascular diseases.METHODS: Data from the 2000/2001 Statistics Canada Canadian Community Health Survey (n=130,880, aged 12 years or older) were analyzed. Second-hand smoke exposure was based on self-report within the...

  6. Prevalence and Correlates of Drug-drug Interactions in the Regional Hospital of Gjilan, Kosovo

    OpenAIRE

    Shabani, Driton; Tahiri, Zejdush; Bara, Petrit; Hudhra, Klejda; Malaj, Ledian; Jucja, Besnik; Bozalia, Adnan; Burazeri, Genc

    2014-01-01

    Aim: Our aim was to assess the prevalence and socioeconomic and clinical correlates of drug-drug interactions among the adult population of transitional Kosovo. Methods: A cross-sectional study was conducted including a representative sample of 1921 patients aged ≥18 years (mean age: 57.8±11.2 years; 50.3% women; overall response: 96%) from the regional hospital of Gjilan, Kosovo, during 2011-2013. Potential drug-drug-interactions were assessed and clinical data as well as demographic and soc...

  7. The Effect of Pharmaceutical Patent Term Length on Research and Development and Drug Expenditures in Canada

    OpenAIRE

    Grootendorst, Paul; Matteo, Livio Di

    2007-01-01

    While pharmaceutical patent terms have increased in Canada, increases in patented drug spending have been mitigated by price controls and retrenchment of public prescription drug subsidy programs. We estimate the net effects of these offsetting policies on domestic pharmaceutical R&D expenditures and also provide an upper-bound estimate on the effects of these policies on Canadian pharmaceutical spending over the period 1988–2002. We estimate that R&D spending increased by $4.4 billion (1997 ...

  8. Factors associated with inability to access addiction treatment among people who inject drugs in Vancouver, Canada

    OpenAIRE

    Prangnell, Amy; Daly-Grafstein, Ben; Dong, Huiru; Nolan, Seonaid; Milloy, M-J; Wood, Evan; Kerr, Thomas; Hayashi, Kanna

    2016-01-01

    Background Addiction treatment is an effective strategy used to reduce drug-related harm. In the wake of recent developments in novel addiction treatment modalities, we conducted a longitudinal data analysis to examine factors associated with inability to access addiction treatment among a prospective cohort of persons who inject drugs (PWID). Methods Data were derived from two prospective cohorts of PWID in Vancouver, Canada, between December 2005 and November 2013. Using multivariate genera...

  9. Prevalence and risk factors of syphilis infection among drug addicts

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    Kuhlmann Thomas

    2005-05-01

    Full Text Available Abstract Background Recent epidemiological data show an increased trend of official estimates for syphilis infection in the general population. Many of the infected cases remain undetected leaving an underestimation of the true prevalence of syphilis in the general population, but also among subpopulations such as illicit drug users. There is limited epidemiological data published on the proportion and risk factors of syphilis infections associated with illicit drug abuse. Methods Illicit drug addicts (n = 1223 in inpatients units in Germany were screened (2000–01 for syphilis and interviewed regarding patterns of drug use and sexual behaviour. TPHA-test for initial screening and FTA-ABS-IgM test in TPHA-positive patients were used. Results In total, TPHA-tests were positive in 39 (3.3% and 7 patients (0.6% were IgM positive. The prevalence rate for syphilis in males was 1.9% and for women it was 8.5%. Female patients were 4.56 (CI 95% 2.37–8.78 times more likely to have a positive TPHA test than males. Sexual behaviours such as high number of sexual partners, sex for drugs/money, sex on the first day were associated with syphilis infection only in women. Females with frequent sex for drugs or money had 4.31 (CI 95% 2.32–8.52 times more likely a reactive TPHA test than remaining patients. Neither the sociodemographic factors nor sexual behaviour were statistically significant associated with syphilis infection among men at all. Conclusion Our data suggest the need for screening for syphilis among these illicit drug users in inpatient settings, in particular among sexual active women. This conclusion is corroborated by the finding of increasing numbers of syphilis infections in the general population. The identification of syphilis cases among drug addicts would give treatment options to these individuals and would help to reduce the spread of infection in this population, but also a spread into heterosexual populations related to

  10. Obesity and Type 2 Diabetes Prevalence in Adults from Two Remote First Nations Communities in Northwestern Ontario, Canada

    OpenAIRE

    Pascal Imbeault; François Haman; Blais, Jules M.; Shinjini Pal; Tim Seabert; Eva M Krümmel; Michael A. Robidoux

    2011-01-01

    Objective. To assess the prevalence rates of obesity and type 2 diabetes in adults from two First Nations communities in northwestern Ontario, Canada. Methods. Body weight, height, and waist circumference as well as fasting and postprandial glucose levels following an oral glucose tolerance test were measured in 31 men and 41 women. Results. The mean age of the sample was 43 ± 13 y. The prevalence of obesity was 65.3% and was comparable between men and women. 90.3% of the individuals presen...

  11. The prevalence and determinants of use of vitamin D supplements among children in Alberta, Canada: a cross-sectional study

    OpenAIRE

    Munasinghe, Lalani L.; Willows, Noreen; Yuan, Yan; Veugelers, Paul J.

    2015-01-01

    Background Limited cutaneous synthesis due to low sun exposure and inadequate dietary intake makes vitamin D supplementation a necessity for many Canadian children. Identification of the factors associated with supplement use is necessary for public health awareness campaigns, but they have not been identified previously. Therefore, the purpose of this study was to assess the prevalence and the determinants of the use of vitamin D supplements among children in the province of Alberta, Canada....

  12. Naturally acquired feline immunodeficiency virus (FIV) infection in cats from western Canada: Prevalence, disease associations, and survival analysis

    OpenAIRE

    Ravi, Madhu; Wobeser, Gary A.; Taylor, Susan M.; Jackson, Marion L.

    2010-01-01

    This retrospective study evaluated epidemiologic features and disease associations of feline immunodeficiency virus (FIV) infection in client owned cats from western Canada. Among 1205 cats that were tested 66 (5.5%) were positive for FIV antibody (FIV+) with a higher prevalence in males than females. FIV+ cats were older than the overall population. Epidemiologic features and disease associations were compared between 58 FIV+, but feline leukemia virus negative (FeLV−) cats and 58 age and se...

  13. Canada

    International Nuclear Information System (INIS)

    This paper reports that the Canadian oil and natural gas sector is in for another grim year in 1992. Further streamlining to enhance operating efficiencies and control costs is the first order of the day. About $4 billion worth of producing properties remains on the market, as corporate focus continues to shift to core properties. New management structures put in place in the last two years will be severely tested to improve the sector's financial performance. Massive write-downs in 1990 and 1991 have put balance sheets in much better shape for improved financial performance in the future. Although new long-term debt exceeded redemptions in 1991, largely because of debt- financing of major capital projects, individually most companies are in better shape through significant debt repayment or restructuring. The substantial reductions in interest rates will also help to enhance discretionary cash flow. At this stage, everything appears to be in place to expect that 1992 will represent the bottom of the down-cycle for Canada

  14. Obesity and Type 2 Diabetes Prevalence in Adults from Two Remote First Nations Communities in Northwestern Ontario, Canada

    Directory of Open Access Journals (Sweden)

    Pascal Imbeault

    2011-01-01

    Full Text Available Objective. To assess the prevalence rates of obesity and type 2 diabetes in adults from two First Nations communities in northwestern Ontario, Canada. Methods. Body weight, height, and waist circumference as well as fasting and postprandial glucose levels following an oral glucose tolerance test were measured in 31 men and 41 women. Results. The mean age of the sample was 43 ± 13 y. The prevalence of obesity was 65.3% and was comparable between men and women. 90.3% of the individuals presented waist circumference levels greater than the thresholds associated with an increased risk of developing health problems. 26 of the 72 individuals (36.1% were found to be type 2 diabetic. The prevalence of diabetes was not different between men and women. Conclusion. Using objective measurements, this study confirms that First Nations adults from remote communities of Canada continue to experience a disproportionately higher prevalence of obesity and type 2 diabetes than nonaboriginal Canadians.

  15. Prevalence of genotypic HIV-1 drug resistance in Thailand, 2002

    Directory of Open Access Journals (Sweden)

    Watitpun Chotip

    2003-03-01

    Full Text Available Abstract Background The prices of reverse transcriptase (RT inhibitors in Thailand have been reduced since December 1, 2001. It is expected that reduction in the price of these inhibitors may influence the drug resistance mutation pattern of HIV-1 among infected people. This study reports the frequency of HIV-1 genetic mutation associated with drug resistance in antiretroviral-treated patients from Thailand. Methods Genotypic resistance testing was performed on samples collected in 2002 from 88 HIV-1 infected individuals. Automated DNA sequencing was used to genotype the HIV-1 polymerase gene isolated from patients' plasma. Results Resistance to protease inhibitors, nucleoside and non-nucleoside reverse transcriptase inhibitors were found in 10 (12%, 42 (48% and 19 (21% patients, respectively. The most common drug resistance mutations in the protease gene were at codon 82 (8%, 90 (7% and 54 (6%, whereas resistant mutations at codon 215 (45%, 67 (40%, 41 (38% and 184 (27% were commonly found in the RT gene. This finding indicates that genotypic resistance to nucleoside reverse transcriptase inhibitors was prevalent in 2002. The frequency of resistant mutations corresponding to non-nucleoside reverse transcriptase inhibitors was three times higher-, while resistant mutation corresponding to protease inhibitors was two times lower than those frequencies determined in 2001. Conclusion This study shows that the frequencies of RT inhibitor resistance mutations have been increased after the reduction in the price of RT inhibitors since December 2001. We believe that this was an important factor that influenced the mutation patterns of HIV-1 protease and RT genes in Thailand.

  16. Drug use prevalence among students of universities of medical sciences in Tehran

    Directory of Open Access Journals (Sweden)

    Farhad Taremian

    2014-02-01

    Full Text Available Objective: This study was aimed to determine the prevalence of drug use among students of universities of Medical Sciences in Tehran. Method: Four thousands of medical students (both sexes in academic year 1388-89 in different level of education, B.A., M.Sc. and Ph.D. were selected by random stratified sampling method. These students were selected from Iran, Tehran and Shahid Beheshti Universities of Medical Sciences considering their sex and level of education. We used drug use prevalence questionnaire. Findings: The most prevalent drug of abuse in life time period was qalyan (classical pipe, followed by cigarette, and alcohol. The least frequent drug of abuse was Shisheh, followed by heroine krack. As we expected, drugs morphine, ritalin and tramadol were placed in forth, fifth and sixth of prevalent drugs. Use of different substances was significantly more prevalent in male students. Conclusion: Using soft drugs (qalyan, cigarette and alcohol was more prevalent than hard drugs (hashish, taryak, heroine kerack among Universities Medical Sciences of Tehran. Similar to drug use pattern in society, use of all of drugs were more prevalent in male students. We should pay special attention to use of drugs such as tramadol, ritalin, petedin and morphine.

  17. Prevalence of alcohol and drug use in injured British Columbia drivers

    Science.gov (United States)

    Brubacher, Jeffrey R; Chan, Herbert; Martz, Walter; Schreiber, William; Asbridge, Mark; Eppler, Jeffrey; Lund, Adam; Macdonald, Scott; Drummer, Olaf; Purssell, Roy; Andolfatto, Gary; Mann, Robert; Brant, Rollin

    2016-01-01

    Objectives Determine the prevalence of drug use in injured drivers and identify associated demographic factors and crash characteristics. Design Prospective cross-sectional study. Setting Seven trauma centres in British Columbia, Canada (2010–2012). Participants Automobile drivers who had blood obtained within 6 h of a crash. Main outcome measures We analysed blood for cannabis, alcohol and other impairing drugs using liquid chromatography/mass spectrometry (LCMS). Results 1097 drivers met inclusion criteria. 60% were aged 20–50 years, 63.2% were male and 29.0% were admitted to hospital. We found alcohol in 17.8% (15.6% to 20.1%) of drivers. Cannabis was the second most common recreational drug: cannabis metabolites were present in 12.6% (10.7% to 14.7%) of drivers and we detected Δ-9-tetrahydrocannabinol (Δ-9-THC) in 7.3% (5.9% to 9.0%), indicating recent use. Males and drivers aged under 30 years were most likely to use cannabis. We detected cocaine in 2.8% (2.0% to 4.0%) of drivers and amphetamines in 1.2% (0.7% to 2.0%). We also found medications including benzodiazepines (4.0% (2.9% to 5.3%)), antidepressants (6.5% (5.2% to 8.1%)) and diphenhydramine (4.7% (3.5% to 6.2%)). Drivers aged over 50 years and those requiring hospital admission were most likely to have used medications. Overall, 40.1% (37.2% to 43.0%) of drivers tested positive for alcohol or at least one impairing drug and 12.7% (10.7% to 14.7%) tested positive for more than one substance. Conclusions Alcohol, cannabis and a broad range of other impairing drugs are commonly detected in injured drivers. Alcohol is well known to cause crashes, but further research is needed to determine the impact of other drug use, including drug–alcohol and drug–drug combinations, on crash risk. In particular, more work is needed to understand the role of medications in causing crashes to guide driver education programmes and improve public safety. PMID:26966054

  18. Continued high prevalence of HIV, HBV and HCV among injecting and noninjecting drug users in Italy

    Directory of Open Access Journals (Sweden)

    Laura Camoni

    2010-03-01

    Full Text Available We estimated the prevalence of HIV, HBV and HCV infections among injecting and non-injecting drug users treated within public drug-treatment centres in Italy to determine the correlates of infection. In the sample of 1330 drug users, the prevalence of HIV was 14.4% among drug injectors and 1.6% among non-injectors; the prevalence of HBV was 70.4% among injecting drug users and 22.8% among non-injectors and of HCV was 83.2% among injecting drug users and 22.0% among non-injectors. Old age, unemployment, and intravenous drug use were significantly correlated with each of the infections, as well as a longer history of injecting drug use. The results indicate that these infections continue to circulate among drug users, highlighting the need for monitoring of this group in Italy.

  19. Health technology assessment of cancer drugs in Canada, the United Kingdom and Australia: should the United States take notice?

    Science.gov (United States)

    Dranitsaris, George; Papadopoulos, George

    2015-06-01

    Cancer remains a global problem, with 7.5 million deaths annually, making it responsible for approximately 13% of deaths from all causes. Cancer also becomes more prevalent as the population ages, making it a major health policy challenge for many countries around the world. However, the encouraging news is that the number of cancer-related deaths has stabilized in many countries. At least part of this success may be attributed to improved diagnosis, early intervention strategies and the development of a newer class of anticancer agents, collectively called "targeted therapies", that are more specific in inhibiting key pathways in tumour genesis. However, these newer drugs are associated with a higher cost. As a result, expenditures for agents and cancer in general have been rising rapidly, far beyond the rate of inflation. Some view this as threatening the very health care systems themselves, which are integral to the modern social contract. Different countries have adopted unique mechanisms to facilitate patient access to these newer agents, with the intent of ensuring value for money and sustainability. In this review, cancer care policies and mechanisms for patient access to new drugs will be discussed and compared between select countries. Given its position as a country that allows free pharmaceutical pricing and multi-payer health insurance, the USA will be the reference country and will be compared with the UK, Canada and Australia, three countries with socialized health care systems and active health technology assessment programmes. PMID:25274258

  20. Prevalence and risk of injury in Europe by driving with alcohol, illicit drugs and medicines

    DEFF Research Database (Denmark)

    Bernhoft, Inger Marie; Hels, Tove; Lyckegaard, Allan;

    2012-01-01

    Prevalence and injury risk of driving with alcohol, illicit drugs and medicines have been estimated as part of the DRUID (Driving under the Influence of Drugs, Alcohol and Medicines) project of FP6. Prevalence in the driving population was based on roadside surveys in thirteen European countries,...

  1. Ethnic and Regional Differences in Prevalence and Correlates of Chronic Diseases and Risk Factors in Northern Canada

    Directory of Open Access Journals (Sweden)

    Joykrishna Sarkar, MSc

    2010-01-01

    Full Text Available IntroductionWe investigated ethnic and geographic variations in major chronic diseases and risk factors in northern Canada, an area that is undergoing rapid changes in its social, cultural, and physical environments.MethodsSelf-report data were obtained from the population-based Canadian Community Health Survey in 2000-2001 and 2005-2006 for Aboriginal and non-Aboriginal respondents from the 3 regions of northern Canada: Yukon, Northwest Territories, and Nunavut. Crude prevalence estimates, adjusted odds ratios (AORs, and confidence intervals were calculated for multiple chronic diseases and risk factors.ResultsThe percentage of Aboriginal respondents who reported having any chronic health condition increased between the 2 cycles of data collection, but did not change for non-Aboriginal respondents. AORs for heart disease, arthritis, and asthma varied by ethnicity or region. AORs for overweight, obesity, daily smoking, regular and binge drinking, and infrequent physical/leisure activity were also substantially different for Aboriginal and non-Aboriginal respondents or among respondents from the 3 northern regions.ConclusionThe changing profile of health in northern Canada suggests a need for action on health policy about the delivery of community-based primary prevention interventions and further research about the determinants of health and health care use.

  2. Prevalence and risk of injury in Europe by driving with alcohol, illicit drugs and medicines.

    OpenAIRE

    Bernhoft, I.M. Hels, T. Lyckegaard, A. Houwing, S. & Verstraete, A.G.

    2012-01-01

    Prevalence and injury risk of driving with alcohol, illicit drugs and medicines have been estimated as part of the DRUID (Driving under the Influence of Drugs, Alcohol and Medicines) project of FP6. Prevalence in the driving population was based on roadside surveys in thirteen European countries, prevalence in seriously injured drivers and killed drivers on data from nine countries. Blood and/or saliva samples were collected and analysed for ethanol, amphetamines, cocaine, cannabis, illicit o...

  3. Who is using e-cigarettes in Canada? Nationally representative data on the prevalence of e-cigarette use among Canadians.

    Science.gov (United States)

    Reid, Jessica L; Rynard, Vicki L; Czoli, Christine D; Hammond, David

    2015-12-01

    The current study examined prevalence and correlates of electronic cigarette (e-cigarette) use in the Canadian population, using data from the nationally representative 2013 Canadian Tobacco, Alcohol and Drugs Survey (n=14,565). Sociodemographic correlates of e-cigarette use (ever, and in the past 30 days) were examined using logistic regression models. Overall, 8.5% of Canadians aged 15 and older reported having ever tried an e-cigarette; 1.8% had used one in the past 30 days. E-cigarette use was particularly high among smokers and young people. Overall, prevalence did not differ between males and females, for ever (P=0.24) or past 30-day use (P=0.30). Smoking status was the strongest correlate of e-cigarette use (ever and in the past 30 days, Pyoung adults aged 20-24 (20.1% ever; 3.9% past 30-day), and decreased with age. Among youth, the majority of e-cigarette users were never-smokers, while the majority of adult users were smokers. In Canada, e-cigarette use is particularly high among smokers and young people. Dual use with cigarettes was common, with most e-cigarette users also smoking conventional cigarettes. Continued monitoring of e-cigarette use and its relationship with smoking should be a priority, given the rapidly-evolving e-cigarette market and implementation of new policy measures. PMID:26348453

  4. CETA and pharmaceuticals: impact of the trade agreement between Europe and Canada on the costs of prescription drugs.

    Science.gov (United States)

    Lexchin, Joel; Gagnon, Marc-André

    2014-01-01

    On a per capita basis, Canadian drug costs are already the second highest in the world after the United States and are among the fastest rising in the Organization for Economic Co-Operation and Development. The Comprehensive Economic and Trade Agreement (CETA) between the European Union (EU) and Canada will further exacerbate the rise in costs by:  Committing Canada to creating a new system of patent term restoration thereby delaying entry of generic medicines by up to two years; Locking in Canada's current term of data protection, and creating barriers for future governments wanting to reverse it;  Implementing a new right of appeal under the patent linkage system that will create further delays for the entry of generics.CETA will only affect intellectual property rights in Canada-not the EU. This analysis estimates that CETA's provisions will increase Canadian drug costs by between 6.2% and 12.9% starting in 2023. The Canadian government committed to compensating provinces for the rise in costs for their public drug plans. Importantly, this means that people paying out-of-pocket for their drugs or receiving them through private insurance, will be charged twice: once through higher drug costs and once more through their federal taxes.As drug costs continue to grow, there are limited options available for provincial/territorial governments: restrict the choice of medicines in public drug plans; transfer costs to patients who typically are either elderly or sick; or take money from other places in the health system, and threaten the viability of Canada's single payer system. CETA will therefore negatively impact the ability of Canada to offer quality health care. PMID:24885309

  5. Temporal trends of alcohol and drug use among Inuit of Northern Quebec, Canada

    Directory of Open Access Journals (Sweden)

    Marilyn Fortin

    2015-12-01

    Full Text Available Background: Alcohol and drug use is a serious health problem for many indigenous populations across Canada, including Inuit. The literature on substance use in these populations is too sparse to devise public health interventions. Objective: The present article portrays alcohol and drug use among Inuit living in Nunavik (Northern Quebec between the 1990s and 2000s, and identifies socio-demographic characteristics related to substance use. Design: The Santé Québec Health Survey (1992 and the Nunavik Inuit Health Survey Qanuippitaa (2004 served as databases for this empirical work. Statistical comparisons were made of substance use variables in the 2 samples. Proportions were compared by chi-square tests (p≤0.05 with benchmarking of statistics for all of Quebec and, when available, all of Canada. Results: Alcohol and drug use among Inuit increased significantly between 1992 and 2004, particularly among young adults. Alcohol users consumed significantly more alcohol per drinking episode than other Canadians in both time periods. Considerable cannabis use was widespread. In 2004, no significant differences in frequencies of heavy drinking episodes were observed by gender, with 60% of drug users consuming alcohol on a regular basis. Conclusions: As in other populations from North America, this study profiles the increase in substance use among Inuit from Nunavik in the first part of the last 20 years. We observed distinct substance use patterns among them in comparison to other Canadians. Such findings, if replicated in the coming years, emphasize the need for major, culturally-relevant public health interventions in this population.

  6. Drug use at licensed premises : prevalence and prevention

    OpenAIRE

    Gripenberg Abdon, Johanna

    2012-01-01

    Background: There are a number of public health concerns related to the use of illicit drugs such as violence, injuries, unprotected sex, and drug dependence. Particularly, there is a strong need to reach adolescents and young adults with drug prevention programs. It is therefore necessary to identify new settings in the community to target young people. The nightlife setting is one arena where many young people socialize, where illicit drugs are available, and where young people are introduc...

  7. Prevalence of asthma and risk factors for asthma-like symptoms in Aboriginal and non-Aboriginal children in the northern territories of Canada

    OpenAIRE

    Zhiwei Gao; Rowe, Brian H; Carina Majaesic; Cindy O’Hara; Senthilselvan, A

    2008-01-01

    BACKGROUND: Few studies have investigated the prevalence and risk factors of asthma in Canadian Aboriginal children.OBJECTIVE: To determine the prevalence of asthma and asthma-like symptoms, as well as the risk factors for asthma-like symptoms, in Aboriginal and non-Aboriginal children living in the northern territories of Canada.METHODS: Data on 2404 children, aged between 0 and 11 years, who participated in the North component of the National Longitudinal Survey of Children and Youth were u...

  8. Prevalence of psychoactive drug use among drivers in Thailand: a roadside survey.

    Science.gov (United States)

    Ingsathit, Atiporn; Woratanarat, Patarawan; Anukarahanonta, Tongtavuch; Rattanasiri, Sasivimol; Chatchaipun, Porntip; Wattayakorn, Kanokporn; Lim, Stephen; Suriyawongpaisal, Paibul

    2009-05-01

    The objective of this study was to determine the prevalence of psychoactive drug and alcohol use among general drivers and predictors of the drug use in Thailand. One thousand six hundred and thirty-five motor vehicle drivers were randomly selected from five geographical regions of Thailand between December 2005 and May 2006. The prevalence of psychoactive drugs was determined using urine tests by gas chromatography/mass spectrometry (GC/MS). Among 1635 drivers, 5.5% were tested positive for breath alcohol with 2% having a level exceeding the legal limit (> or =50mg%). Psychoactive drug was presented in 158 (9.7%) urine samples for drug analysis. The top 3 most frequently detected licit drugs were antihistamines (2.0%), sedative cough suppressant (0.7%) and benzodiazepines (0.2%). Illicit drugs detected included amphetamine (1.8%), cannabis (1.1%), mitragynine (Kratom) (0.9%) and morphine (0.1%). Only type of driver (commercial/non-commercial) was a significant predictor with psychoactive drug use. The prevalence of psychoactive drug use among drivers not involved in road crashes in Thailand was not as low as an earlier study in Europe using objective measurements, particularly among commercial drivers. However, for illicit drugs, the prevalence detected in this study was lower than those of earlier studies from high-income countries. PMID:19393795

  9. Prevalence of asthma symptoms among adults aged 20-44 years in Canada

    DEFF Research Database (Denmark)

    Manfreda, J; Becklake, M R; Sears, M R; Chan-Yeung, M; Dimich-Ward, H; Siersted, H C; Ernst, P; Sweet, L; Van Til, L; Bowie, D M; Anthonisen, N R; Tate, R B

    2001-01-01

    Reported prevalence rates of asthma vary within and between countries around the world. These differences suggest environmental factors in addition to genetic factors in the cause of the disease and may provide clues for preventive strategies. We examined the variability of asthma-related symptom...

  10. Drug use Prevalence among College Students of Ministry of Sceince, Research and Technology, Iran (2012)

    OpenAIRE

    Hamid Yaghubi; Farhad Taremian; Hamid Peyravi; Masoud Zafar

    2015-01-01

    Introduction: This study was aimed to determine the prevalence of drug use among College Students of Ministry of Sceince, Research and Technology in Iran. Method: Seven thousands, three hundred and thirty student in academic year 2011-2012 were selected by random stratified sampling method from thirty Universities In Iran, considering their sex and level of education. We used Drug Use Prevalence Questionnaire (Taremian, Bolhari and peyravi, 2007) which were modified according to objectives...

  11. Surveying Teens in School to Assess the Prevalence of Problematic Drug Use

    Science.gov (United States)

    Falck, Russel S.; Nahhas, Ramzi W.; Li, Linna; Carlson, Robert G.

    2012-01-01

    Background: Illicit drug use by school-aged teens can adversely affect their health and academic achievement. This study used a survey administered in schools to assess the prevalence of problematic drug use among teenagers in a Midwestern community. Methods: Self-report data were collected from 11th- and 12th-grade students (N = 3974) in 16…

  12. Guidance on The Use of Antiviral Drugs for Influenza in Acute Care Facilities in Canada, 2014-2015

    OpenAIRE

    H Grant Stiver; Evans, Gerald A; Fred Y Aoki; Allen, Upton D.; Michel Laverdière

    2015-01-01

    This article represents the second update to the AMMI Canada Guidelines document on the use of antiviral drugs for influenza. The article aims to inform health care professionals of the increased risk for influenza in long-term care facilities due to a documented mismatch between the components chosen for this season’s vaccine and currently circulating influenza strains. Adjusted recommendations for the use of antiviral drugs for influenza in the acute care setting for this season are provide...

  13. Pay close attention to prevalence and treatment of multi-drug-resistant tuberculosis

    Directory of Open Access Journals (Sweden)

    Hong-bing CHEN

    2011-03-01

    Full Text Available Multi-drug-resistant tuberculosis(MDR-TB and extensive-drug-resistant tuberculosis(XDR-TB has become more prevalent worldwide.It is a disease which is difficult and expensive to treatment,with poor prognosis and high mortality.The spread of HIV accelerated the progression of malignancy of infection of tuberculosis.The evolution of MDR-and XDR-Mycobacterium tuberculosis had been a complicated and dynamic process related to the drug-resistant genes and phenotypes.The new diagnostic and therapeutic methods,research on vaccines,and the research and application of new drugs would be conducive to inhibit the prevalence of MDR-TB and XDR-TB.Prevention of initial drug-resistance infection should be emphasized in the prevention of drug-resistant TB.

  14. Methodology for evaluating Insite: Canada's first medically supervised safer injection facility for injection drug users

    Directory of Open Access Journals (Sweden)

    Wood Evan

    2004-11-01

    Full Text Available Abstract Many Canadian cities are experiencing ongoing infectious disease and overdose epidemics among injection drug users (IDUs. In particular, Human Immunodeficiency Virus (HIV and hepatitis C Virus (HCV have become endemic in many settings and bacterial and viral infections, such as endocarditis and cellulitis, have become extremely common among this population. In an effort to reduce these public health concerns and the public order problems associated with public injection drug use, in September 2003, Vancouver, Canada opened a pilot medically supervised safer injecting facility (SIF, where IDUs can inject pre-obtained illicit drugs under the supervision of medical staff. The SIF was granted a legal exemption to operate on the condition that its impacts be rigorously evaluated. In order to ensure that the evaluation is appropriately open to scrutiny among the public health community, the present article was prepared to outline the methodology for evaluating the SIF and report on some preliminary observations. The evaluation is primarily structured around a prospective cohort of SIF users, that will examine risk behavior, blood-borne infection transmission, overdose, and health service use. These analyses will be augmented with process data from within the SIF, as well as survey's of local residents and qualitative interviews with users, staff, and key stakeholders, and standardised evaluations of public order changes. Preliminary observations suggest that the site has been successful in attracting IDUs into its programs and in turn helped to reduce public drug use. However, each of the indicators described above is the subject of a rigorous scientific evaluation that is attempting to quantify the overall impacts of the site and identify both benefits and potentially harmful consequences and it will take several years before the SIF's impacts can be appropriately examined.

  15. Registration for public drug benefits across areas of differing ethnic composition in British Columbia, Canada

    Directory of Open Access Journals (Sweden)

    Wong Sabrina T

    2010-06-01

    Full Text Available Abstract Background In 2003, the government of British Columbia, Canada introduced a universal drug benefit plan to cover drug costs that are high relative to household income. Residents were required to register in order to be eligible for the income-based benefits. Given past research suggesting that registration processes may pose an access barrier to certain subpopulations, we aimed to determine whether registration rates varied across small geographic areas that differed in ethnic composition. Methods Using linked population-based administrative databases and census data, we conducted multivariate logistic regression analyses to determine whether the probability of registration for the public drug plan varied across areas of differing ethnic composition, controlling for household-level predisposing, enabling and needs factors. Results The adjusted odds of registration did not differ across regions characterized by high concentrations (greater than 30% of residents identifying as North American, British, French or other European. Households located in areas with concentrations of residents identifying as an Asian ethnicity had the highest odds of program registration: Chinese (OR = 1.21, CI: 1.19-1.23 and South Asian (OR = 1.19, CI: 1.16-1.22. Despite this positive finding, households residing in areas with relatively high concentrations of recent immigrants had slightly lower adjusted odds of registering for the program (OR = 0.97, CI: 0.95-0.98. Conclusions This study identified ethnic variation in registration for a new public drug benefit program in British Columbia. However, unlike previous studies, the variation observed did not indicate that areas with high concentrations of certain ethnicities experienced disadvantages. Potential explanations are discussed.

  16. Prevalence and Patterns of Nitrosatable Drug Use among U.S. Women during Early Pregnancy

    OpenAIRE

    Brender, Jean D.; Kelley, Katherine E.; Werler, Martha M.; Langlois, Peter H.; Suarez, Lucina; Canfield, Mark A.; ,

    2011-01-01

    BACKROUND Experimental evidence indicates that certain drugs, that are secondary or tertiary amines or amides, form N-nitroso compounds in the presence of nitrite in an acidic environment. Nitrosatable drugs have been associated with birth defects in a few epidemiologic studies. This study describes the prevalence and patterns of nitrosatable drug use among U.S. women during early pregnancy and examines maternal factors associated with such use. METHODS Data were analyzed from the National Bi...

  17. CETA and pharmaceuticals: impact of the trade agreement between Europe and Canada on the costs of prescription drugs

    OpenAIRE

    Lexchin, Joel; Gagnon, Marc-André

    2014-01-01

    On a per capita basis, Canadian drug costs are already the second highest in the world after the United States and are among the fastest rising in the Organization for Economic Co-Operation and Development. The Comprehensive Economic and Trade Agreement (CETA) between the European Union (EU) and Canada will further exacerbate the rise in costs by: • Committing Canada to creating a new system of patent term restoration thereby delaying entry of generic medicines by up to two years; • Locking i...

  18. Drug use in Ireland and Northern Ireland 2010/11 Drug Prevalence Survey: Cannabis Results Bulletin 3

    OpenAIRE

    Department of Health (Ireland)

    2013-01-01

    This bulletin presents findings regarding the use of cannabis in Ireland from the third drug prevalence survey of households in Ireland and Northern Ireland. A representative sample of adults aged between 15 and 64 years was sampled during late 2010 and early 2011. Click here to download PDF 894kb

  19. Prevalence and Risk Factors of Primary Drug-Resistant Tuberculosis in China

    Institute of Scientific and Technical Information of China (English)

    WANG Sheng Fen; ZHOU Yang; PANG Yu; ZHENG Hui Wen; ZHAO Yan Lin

    2016-01-01

    ObjectiveTo investigatetheprevalence of primary drug-resistant tuberculosis (TB) and associated risk factors in China.We also explored factors contributing tothe transmission of multidrug-resistant tuberculosis (MDR-TB). MethodsA total of 2794 representative,Mycobacterium tuberculosis isolates from treatment-naive patients were subjected to drug susceptibility testing, and risk factors for drug-resistant TBwere analyzed. We also analyzed MDR-TB strain sublineages, drug-resistance-conferring mutations, and risk factors associated with clustered primary MDR strains. ResultsAmong 2794Mycobacterium tuberculosis isolates from treatment-naive patients, the prevalence of any resistance to first-line drugs was 33.2%andthe prevalence of MDR-TB was 5.7%. We did not find any risk factors significantly associated with resistance to first-line drugs.The93 primary MDR-TB isolates were classified into six sublineages, of which, 75 (80.6%) isolates were the RD105-deleted Beijing lineage.The largest sublineage included 65 (69.9%) isolates with concurrent deletions of RD105, RD207, and RD181.Twenty-nine (31.2%) primary MDR strains grouped in clusters;MDR isolates in clusters were more likely to have S531LrpoBmutation. ConclusionThis study indicates that primary drug-resistantTBand MDR-TBstrains are prevalent in China,and multiplemeasures should be taken toaddress drug-resistant TB.

  20. Prevalence of Sexually Transmitted Diseases Among New Female Drug Abusers in a Rehabilitation Centre

    OpenAIRE

    Nordin, Rusli Bin; Rahman Bin Isa, Abdul; Rusli Bin Abdullah, Mohamed

    2001-01-01

    The prevalence of sexually transmitted diseases (STD) among female drug abusers was studied by screening 130 new inmates of a rehabilitation centre. Data was collected using a structured questionnaire, physical examination and specimen collection for laboratory investigation at the Community Medicine Clinic of HUSM. The majority (64.6%) were Malays and self-confessed sex workers (77.7%). A high prevalence of syphilis (50.8%), hepatitis B (52.2%), moniliasis (23.8%), trichomoniasis (19.2%) and...

  1. How could preventive therapy affect the prevalence of drug resistance? Causes and consequences.

    Science.gov (United States)

    Kunkel, Amber; Colijn, Caroline; Lipsitch, Marc; Cohen, Ted

    2015-06-01

    Various forms of preventive and prophylactic antimicrobial therapies have been proposed to combat HIV (e.g. pre-exposure prophylaxis), tuberculosis (e.g. isoniazid preventive therapy) and malaria (e.g. intermittent preventive treatment). However, the potential population-level effects of preventative therapy (PT) on the prevalence of drug resistance are not well understood. PT can directly affect the rate at which resistance is acquired among those receiving PT. It can also indirectly affect resistance by altering the rate at which resistance is acquired through treatment for active disease and by modifying the level of competition between transmission of drug-resistant and drug-sensitive pathogens. We propose a general mathematical model to explore the ways in which PT can affect the long-term prevalence of drug resistance. Depending on the relative contributions of these three mechanisms, we find that increasing the level of coverage of PT may result in increases, decreases or non-monotonic changes in the overall prevalence of drug resistance. These results demonstrate the complexity of the relationship between PT and drug resistance in the population. Care should be taken when predicting population-level changes in drug resistance from small pilot studies of PT or estimates based solely on its direct effects. PMID:25918446

  2. Drug use prevalence among students of universities of medical sciences in Tehran

    OpenAIRE

    Farhad Taremian; Jafar Bolhari; Hamid Peyravi; Ali Asgari

    2014-01-01

    Objective: This study was aimed to determine the prevalence of drug use among students of universities of Medical Sciences in Tehran. Method: Four thousands of medical students (both sexes) in academic year 1388-89 in different level of education, B.A., M.Sc. and Ph.D. were selected by random stratified sampling method. These students were selected from Iran, Tehran and Shahid Beheshti Universities of Medical Sciences considering their sex and level of education. We used drug use prevalence q...

  3. Prevalence of anti-ulcer drug use in a Chinese cohort

    Institute of Scientific and Technical Information of China (English)

    Tzeng-Ji Chen; Li-Fang Chou; Shinn-Jang Hwang

    2003-01-01

    AIM: To estimate the age-specific prevalence of anti-ulcer drug use and to calculate the usage of different anti-ulcer drugs over 5 years within the universal health insurance program in Taiwan area. METHODS: The National Health Insurance Research Database in Taipei supplied the cohort data sets of 200 000people. The ambulatory and inpatient claims of the cohort from 1997 to 2001 were analyzed. The anti-ulcer drugs included all drug items of the group A02B (drugs for treatment of peptic ulcer) in the Anatomical Therapeutic Chemical classification system (version 2000). The amount of drug usage was measured in unit of defined daily dose. RESULTS: Among bhe totally 13 034 393 visits wibh 56 672 631ambulatory prescription items, there were 398 150 (0.7 %)prescribed items of anti-ulcer drugs in 378 855 (2.9 %)visits. Among the 107 649 admissions with 5 762 312inpatient prescription items, there were 24 598 (0.4 %)prescribed items of anti-ulcer drugs in 11 548 (10.7 %)admissions. The annual prevalence of anti-ulcer drug use was 9.6 % in 1997, 11.6 % in 1998, 15.4 % in 1999, 14.5 %in 2000, and 15.9 % in 2001 respectively. The 5-year prevalence was 36.1%. The age-specific prevalence among the people younger than 20 years was 9.2 % in 2001 and 23.7 % during the 5-year period. Cimetidine not only was the most popular ingredient among anti-ulcer drugs (57 634cimetidine users in 70 729 all anti-ulcer drug users during the 5-year period) but also had the largest prescribed amount (42.3 % of DDDs for all anti-ulcer drug users during the 5-year period). The annually prescribed amount of anti-ulcer drugs had grown from 4.9 DDDs/1000 inhabitants/day in 1997 to 7.5 in 2001. This increase was largely attributed to H2-receptor antagonists and the expanding number of users. CONCLUSION: Prescribing of anti-ulcer drugs is indeed popular among the Chinese population in Taiwan area. The disproportionate use of anti-ulcer drugs by children demands further investigation.

  4. Drug Abuse Prevalence and Risk Factors in Students of Shaheed Sadoughi University of Medical Sciences, Yazd

    Directory of Open Access Journals (Sweden)

    Z Poormovahed

    2010-08-01

    Full Text Available Introduction: Addiction and drug abuse in one of the most important health, social and political problems in the world, especially in developing countries. Nowadays this problem has higher prevalence in young people, and so students of the universities are at risk. The aim of this study was to identify drug abuse prevalence and risk factors in students of Shaheed Sadoughi Medical University, Iran, Yazd Methods: This was a descriptive cross sectional study and 534 students were selected through random sampling from different medical sciences colleges. The data was collected by self-designed questionnaire and interview, and then analyzed using SPSS software and chi-square test. Results: Data showed the prevalence of drug abuse in students to be 21.5%, frequency of drug abuse was as follows: Hookah 15.9%, cigarette 24.13%, opium 2.8%. The major risk factors were amusement 47.4% and unemployment 42.98%. It was higher in single males who lived in university dormitories. Conclusion: According to the study results, it is recommended that families and university managers facilitate student's entertainment, marriage and occupation. The high prevalence of smoking hookah which is usually accompanied by use of other drugs should be considered in educational programs.

  5. Prevalence of and risk factors for hock and knee injuries on dairy cows in tiestall housing in Canada.

    Science.gov (United States)

    Nash, C G R; Kelton, D F; DeVries, T J; Vasseur, E; Coe, J; Heyerhoff, J C Zaffino; Bouffard, V; Pellerin, D; Rushen, J; de Passillé, A M; Haley, D B

    2016-08-01

    Leg injuries on dairy cows are a common and highly visible welfare concern on commercial dairy farms. With greater attention being placed on food animal welfare and limited research being conducted on tiestall farms, this study aimed to identify prevalence and risk factors for hock and knee injuries on dairy cows housed in tiestall barns in Ontario (n=40) and Quebec (n=60). A sample of 40 cows was purposively selected per farm and several animal- and farm-based measures were taken. Both hocks and both knees on each cow were scored as injured (presence of lesions or swelling) or not injured (no alterations or hair loss), and the highest score of each of the 2 knees and the 2 hocks was considered the cow's hock or knee score. Possible animal- and farm-based risk factors were incorporated into 2 separate multivariable logistic models for hock injuries and knee injuries respectively at the cow level. Mean (±SD) percentage of cow with hock injuries per farm was found to be 56±18% and mean percentage of knee injuries per farm was found to be 43±23%. Animal-based factors found to be associated with a greater odds of hock injuries at the cow level were increased days in milk (DIM), lower body condition score (BCS), lameness, higher parity, higher cow width, median lying bout duration, and median number of lying bouts. Environmental factors found to be associated with hock injuries at the cow level were province, stall width, tie rail position, stall base, chain length, and age of stall base. Animal-based factors found to be associated with knee injuries at the cow level were DIM, BCS, and median lying time. Environmental factors found to be associated with knee injuries at the cow level were stall width, chain length, province, stall base, and bed length. Quadratic and interaction terms were also identified between these variables in both the hock and knee models. This study demonstrates that hock and knee injuries are still a common problem on tiestall dairy farms in

  6. Prevalência do uso de drogas e desempenho escolar entre adolescentes Drug use prevalence and school performance among teenagers

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    Beatriz Franck Tavares

    2001-04-01

    Full Text Available OBJETIVO: Avaliar a prevalência do uso de drogas entre adolescentes de escolas com segundo grau. MÉTODOS: Com base em um delineamento transversal, foi realizado estudo em 1998 , em Pelotas, RS. Um questionário anônimo, auto-aplicado em sala de aula, foi respondido por uma amostra proporcional de estudantes com idade entre 10 e 19 anos, matriculados no primeiro grau (a partir da 5ª série e no segundo grau, em todas as escolas públicas e particulares na zona urbana do município que tinham segundo grau. Realizou-se até três revisitas para aplicação aos alunos ausentes. RESULTADOS: Foram entrevistados 2.410 estudantes e o índice de perdas foi de 8%. As substâncias mais consumidas, alguma vez na vida, foram álcool (86,8%, tabaco (41,0%, maconha (13,9%, solventes (11,6%, ansiolíticos (8,0%, anfetamínicos (4,3% e cocaína (3,2%. Os meninos usaram mais do que as meninas maconha, solventes e cocaína, enquanto elas usaram mais ansiolíticos e anfetamínicos. Uso no mês, uso freqüente, uso pesado e intoxicações por álcool foram mais prevalentes entre os meninos. Após controle para fatores de confusão, permaneceu positiva a associação entre uso de drogas (exceto álcool e tabaco e turno escolar noturno, maior número de faltas à escola no mês anterior e maior número de reprovações escolares. CONCLUSÕES: A prevalência de experimentação de drogas em adolescentes escolares é alta, sendo importante detectar precocemente grupos de risco e desenvolver políticas de prevenção do abuso e dependência dessas substâncias.OBJECTIVE: To assess the prevalence of drug use among teenagers. METHODS: A cross-sectional study was carried out in Pelotas, Southern Brazil, in 1998 . An anonymous, self-administered questionnaire was answered by a sample of 2,410 students with ages ranging from 10 to 19 years old, registered in all public and private high schools of the area. The schools were visited up to three times to reach absent

  7. Prevalence and characteristics of psychotropic drug use in institutionalized children and adolescents with mild intellectual disability.

    Science.gov (United States)

    Scheifes, Arlette; de Jong, Daniël; Stolker, Joost Jan; Nijman, Henk L I; Egberts, Toine C G; Heerdink, Eibert R

    2013-10-01

    Psychotropic drugs are a cornerstone in the treatment of psychopathology and/or behavioral problems in children with intellectual disability (ID), despite concerns about efficacy and safety. Studies on the prevalence of psychotropic drug use have mainly been focused on adults with ID or children without ID. Therefore the aim of this cross sectional study was to assess the prevalence and characteristics of psychotropic drug use in children with mild ID who were institutionalized in specialized inpatient treatment facilities in The Netherlands. Demographic data, psychiatric diagnoses, the nature of the behavioral problems, level of intellectual functioning, and medication data were extracted from medical records using a standardized data collection form. Adjusted relative risks (ARR) for the association between patient characteristics and psychotropic drug use were estimated with Cox regression analysis. Of the 472 included children, 29.4% (n=139) used any psychotropic drug, of which 15.3% (n=72) used antipsychotics (mainly risperidone), and 14.8% (n=70) used psychostimulants (mainly methylphenidate). Age, sex, and behavioral problems were associated with psychotropic drug use. Boys had a 1.7 (95%CI 1.1-2.4) higher probability of using psychotropic drugs, compared to girls adjusted for age and behavioral problems. Having any behavioral problem was associated with psychotropic drug use with an ARR of 2.1 (95%CI 1.3-3.3), adjusted for sex and age. The high prevalence of psychotropic drug use in children with ID is worrisome because of the lack of evidence of effectiveness (especially for behavioral problems) at this young age, and the potential of adverse drug reactions. PMID:23886758

  8. Prevalence of drug-resistant tuberculosis in mainland China: systematic review and meta-analysis.

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    Yu Yang

    Full Text Available BACKGROUND: The spread of drug-resistant tuberculosis (TB is one of the major public health problems in the world. Surveillance of anti-TB drug resistance is important for monitoring TB control strategies. However, the status of drug-resistant TB in China has been reported inconsistently. METHODS: We systematically reviewed published studies on drug-resistant TB in China until March 31, 2011, and quantitatively summarized prevalence and patterns of anti-TB drug resistance among new cases and previously treated cases, respectively. RESULTS: Ninety-five eligible articles, published during 1993-2011, were included in this review. The meta-analyses showed that the prevalence of drug-resistant TB in new cases was 27.9% (95% CI, 25.6%-30.2% (n/N = 27,360/104,356 and in previously treated cases was 60.3% (95% CI, 56.2%-64.2% (n/N = 30,350/45,858. Furthermore, in these two study populations, the prevalence of multiple drug resistance was found to be 5.3% (95% CI, 4.4%-6.4% (n/N = 8810/101,718 and 27.4% (95% CI, 24.1%-30.9% (n/N = 10,486/44,530 respectively. However, the results were found to be frequently heterogeneous (p for Q tests <0.001. The most common resistance was observed for isoniazid among both study populations. Different patterns of drug resistance were observed in the subgroup analysis with respect to geographic areas, drug susceptibility testing methods and subject enrollment time. CONCLUSIONS: Results of meta-analyses indicated a severe status of drug-resistant TB in China, which attaches an importance to strength TB prevention and control.

  9. Use of antipsychotic drugs in individuals with intellectual disability (ID) in the Netherlands : prevalence and reasons for prescription

    NARCIS (Netherlands)

    de Kuijper, G.; Hoekstra, P.; Visser, F.; Scholte, F. A.; Penning, C.; Evenhuis, H.

    2010-01-01

    Background We investigated antipsychotic drug prescription practice of Dutch ID physicians, studying prevalence of antipsychotic drug use, reasons for prescription and the relationship between these reasons and patient characteristics. Methods A cross-sectional study of medical and pharmaceutical re

  10. Qualitative investigation of barriers to accessing care by people who inject drugs in Saskatoon, Canada: perspectives of service providers

    OpenAIRE

    Lang, Katherine; Neil, Jaycie; Wright, Judith; Dell, Colleen Anne; Berenbaum, Shawna; El-Aneed, Anas

    2013-01-01

    Background People who inject drugs (PWID) often encounter barriers when attempting to access health care and social services. In our previous study conducted to identify barriers to accessing care from the perspective of PWIDs in Saskatoon, Canada: poverty, lack of personal support, discrimination, and poor knowledge and coordination of service providers among other key barriers were identified. The purpose of the present investigation was to explore what service providers perceive to be the ...

  11. The prevalence of acute cutaneous drug reactions in a Scandinavian University hospital

    DEFF Research Database (Denmark)

    Borch, Jacob Eli; Andersen, Klaus Ejner; Bindslev-Jensen, Carsten

    2006-01-01

    To investigate the epidemiology of acute cutaneous adverse drug reactions, a cross-sectional study was designed with four visits, equally distributed over one year, to all clinical departments of a large university hospital in order to find patients with possible drug-induced exanthema of less than...... 2 weeks' duration. Patients were examined clinically and offered investigation for possible drug allergy, including blood tests, and skin tests when appropriate. Subsequent drug challenge tests were performed in selected cases. Finally, the history and test results were evaluated to determine the...... imputability of each drug as the possible culprit. In a cohort of 11,371 in- and out-patients, 131 were referred for evaluation. Twenty-nine cases of acute cutaneous drug reactions were identified, giving a prevalence of 0.33% in in-patients, 0.14% in out-patients, and 0.25% overall. Twenty-five percent of the...

  12. Prevalência do consumo de drogas na FEBEM, Porto Alegre Drug use prevalence at FEBEM, Porto Alegre

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    Maristela Ferigolo

    2004-03-01

    já terem utilizado drogas ilícitas.OBJECTIVE: This study aimed to determine the prevalence of drug use among institutionalized children and adolescents; to assess the degree of associated use of illicit drugs with alcohol and tobacco; and to determine which is the gateway drug to illicit drug use. METHODS: A cross-sectional study was carried out in the Fundação Estadual do Bem-Estar do Menor, in Porto Alegre (FEBEM Southern Brazil. A questionnaire developed by the World Health Organization to determine prevalence off drug use was answered anonymously by a population of literate minors who were in FEBEM because of delinquency or due to social risk. The analysis aimed to describe the frequency of use of each drug and relate it to gender, age of beginning, and reason of institutionalization. RESULTS: A total of 382 participants answered the questionnaire. The substances most frequently used on an experimental basis were: alcohol (81,3%, tobacco (76,8%, marijuana (69,2%, cocaine (54,6%, inhalants (49,2%, anxiolytic drugs (13,4%, hallucinogens (8,4%, amphetamines (6,5% and barbiturates (2,4%. Overall, around 80% of the respondents reported having used some illicit drug at least once in the past. Licit drugs, like alcohol and tobacco, were used mainly by males, while medicines were used mostly by females. Adolescents with delinquency records showed a significantly higher frequency of alcohol, marijuana, cocaine, and solvent use. The mean age of beginning was under 12 years for alcohol and tobacco use, under 13 years for marijuana and inhalants, and under 14 years for cocaine. Concomitant use of illicit and licit drugs was found to be high in this population. CONCLUSIONS: A high prevalence of precocious drug use was found among institutionalized children and adolescent, with alcohol and tobacco being used earlier than illicit drugs. Delinquent males were more likely to have used illicit drugs.

  13. Estimating prevalence of accumulated HIV-1 drug resistance in a cohort of patients on antiretroviral therapy

    DEFF Research Database (Denmark)

    Bannister, Wendy P; Cozzi-Lepri, Alessandro; Kjær, Jesper;

    2011-01-01

    Estimating the prevalence of accumulated HIV drug resistance in patients receiving antiretroviral therapy (ART) is difficult due to lack of resistance testing at all occasions of virological failure and in patients with undetectable viral load. A method to estimate this for 6498 EuroSIDA patients...

  14. How Will We Crack the Ice and Smack the Chronic, Sugar and Coke? The Control of Illicit Drugs in Canada. The Front Line.

    Science.gov (United States)

    Kilgour, David

    1997-01-01

    Maintains that Canada's expansive geography, endless, uninhabited coastlines, and long border make it vulnerable as an entry point for illegal drugs. Briefly reviews recent revelations regarding increased drug use and money laundering. Recommends stiffening current drug laws and increasing spending for education and rehabilitation. (MJP)

  15. Prevalence of potential drug-drug interactions among internal medicine ward in University of Gondar Teaching Hospital, Ethiopia

    Institute of Scientific and Technical Information of China (English)

    Akshaya Srikanth Bhagavathula; Alemayehu Berhanie; Habtamu Tigistu; Yishak Abraham; Yosheph Getachew; Tahir Mehmood Khan; Chandrashekhar Unakal

    2014-01-01

    Objective: To determine the prevalence, clinical significance and the associated risk factors of potential drug-drug interactions (DDIs) at internal medicine ward of University of Gondar (UOG) hospital.Method:medicine ward of UOG hospital from April 29, 2013 to June 2, 2013. Data was collected from medical records and by interviewing the patients face to face. Descriptive analysis was conducted for back ground characteristics and logistic regression was used to determine the associated risk factors.Result:A prospective cross-sectional study was conducted on patients treated in internal interacting combinations with 4.13 potential DDIs per patient. Among 413 potential DDIs most were of moderate interactions 61.2% (n=253) followed by 26% (n=107) of minor interactions and 12.8% (n=53) of major interactions. There was significant association of occurrence of potential DDIs only with taking three or more medications.Conclusion:We have recorded a high rate of prevalence of potential DDI in the internal In our study, we have identified a total number of 413 potential DDIs and 184 types of medicine ward of UOG hospital and a high number of clinically significant DDIs which the most prevalent DDI were of moderate severity. Careful selection of drugs and active pharmaceutical care is encouraged in order to avoid negative consequences of these interactions.

  16. Rising Obesity Prevalence and Weight Gain Among Adults Starting Antiretroviral Therapy in the United States and Canada.

    Science.gov (United States)

    Koethe, John R; Jenkins, Cathy A; Lau, Bryan; Shepherd, Bryan E; Justice, Amy C; Tate, Janet P; Buchacz, Kate; Napravnik, Sonia; Mayor, Angel M; Horberg, Michael A; Blashill, Aaron J; Willig, Amanda; Wester, C William; Silverberg, Michael J; Gill, John; Thorne, Jennifer E; Klein, Marina; Eron, Joseph J; Kitahata, Mari M; Sterling, Timothy R; Moore, Richard D

    2016-01-01

    The proportion of overweight and obese adults in the United States and Canada has increased over the past decade, but temporal trends in body mass index (BMI) and weight gain on antiretroviral therapy (ART) among HIV-infected adults have not been well characterized. We conducted a cohort study comparing HIV-infected adults in the North America AIDS Cohort Collaboration on Research and Design (NA-ACCORD) to United States National Health and Nutrition Examination Survey (NHANES) controls matched by sex, race, and age over the period 1998 to 2010. Multivariable linear regression assessed the relationship between BMI and year of ART initiation, adjusting for sex, race, age, and baseline CD4(+) count. Temporal trends in weight on ART were assessed using a generalized least-squares model further adjusted for HIV-1 RNA and first ART regimen class. A total of 14,084 patients from 17 cohorts contributed data; 83% were male, 57% were nonwhite, and the median age was 40 years. Median BMI at ART initiation increased from 23.8 to 24.8 kg/m(2) between 1998 and 2010 in NA-ACCORD, but the percentage of those obese (BMI ≥30 kg/m(2)) at ART initiation increased from 9% to 18%. After 3 years of ART, 22% of individuals with a normal BMI (18.5-24.9 kg/m(2)) at baseline had become overweight (BMI 25.0-29.9 kg/m(2)), and 18% of those overweight at baseline had become obese. HIV-infected white women had a higher BMI after 3 years of ART as compared to age-matched white women in NHANES (p = 0.02), while no difference in BMI after 3 years of ART was observed for HIV-infected men or non-white women compared to controls. The high prevalence of obesity we observed among ART-exposed HIV-infected adults in North America may contribute to health complications in the future. PMID:26352511

  17. Nursing home patients with diabetes: Prevalence, drug treatment and glycemic control

    OpenAIRE

    Andreassen, Lillan Mo; Sandberg, Sverre; Kristensen, Gunn Berit Berge; Sølvik, Una Ørvim; Kjome, Reidun Lisbet Skeide

    2014-01-01

    Aims: Determine prevalence of diabetes, and describe use of blood glucose lowering (BGL) drugs and glycemic control in Norwegian nursing homes. Methods: In this cross-sectional study we collected details of BGL drugs, capillary blood glucose measurements (CBGM) in the last four weeks and HbA1c measurements in the last 12 months from the medical records of patients with diabetes, within a population of 742 long-term care patients from 19 randomly selected nursing homes in Western Norway. De...

  18. Use of neuroenhancement drugs: prevalence, frequency and use expectations in Switzerland

    OpenAIRE

    Stéphane Deline; Stéphanie Baggio; Joseph Studer; Alexandra A. N'Goran; Marc Dupuis; Yves Henchoz; Meichun Mohler-Kuo; Jean-Bernard Daeppen; Gerhard Gmel

    2014-01-01

    Objective: The present study investigates the use expectations, prevalence and frequency of neuroenhancement drug (ND) use among the Swiss male population, separating college students from others. Methods: Young Swiss men were invited to participate in the Cohort Study on Substance Use Risk Factors. A total of 5,967 participants responded to questions on six types of NDs (wakefulness medication, antidepressants, Alzheimer’s disease medication, Parkinson’s disease medication, attention deficit...

  19. Use of neuroenhancement drugs: prevalence, frequency and use expectations in Switzerland

    OpenAIRE

    Deline, Stéphane; Baggio, Stéphanie; Studer, Joseph; N Goran, Alexandra A; Dupuis, Marc; Henchoz, Yves; Mohler-Kuo, Meichun; Daeppen, Jean-Bernard; Gmel, Gerhard

    2014-01-01

    OBJECTIVE: The present study investigates the use expectations, prevalence and frequency of neuroenhancement drug (ND) use among the Swiss male population, separating college students from others. METHODS: Young Swiss men were invited to participate in the Cohort Study on Substance Use Risk Factors. A total of 5,967 participants responded to questions on six types of NDs (wakefulness medication, antidepressants, Alzheimer's disease medication, Parkinson's disease medication, attention defi...

  20. Prevalence of Human Immunodeficiency Virus Infection among Injection Drug Users Released from Jail

    OpenAIRE

    Moradi, Ali Reza; Emdadi, Abbas; Soori, Bahram; Mostafavi, Ehsan

    2012-01-01

    Background Injecting drug users (IDUs) and prisoners are considered to be highly vulnerable to human immunodeficiency virus (HIV) infection in Iran. This study was carried out to determine the prevalence of HIV infection among IDUs released from jail in Bahar (Hamadan, Iran). Methods In a cross-sectional study, 118 IDUs who were prisoners during 2001-07 were evaluated. Their demographic and personal characteristics were assessed by a questionnaire. In order to determine HIV-positive individua...

  1. Prevalence of use of performance enhancing drugs by fitness centre members.

    Science.gov (United States)

    Stubbe, Janine H; Chorus, Astrid M J; Frank, Laurence E; de Hon, Olivier; van der Heijden, Peter G M

    2014-05-01

    Studies on the use of performance enhancing drugs (PED) in fitness centres rely predominately on conventional survey methods using direct questioning. However, research indicates that direct questioning of sensitive information is characterized by under-reporting. The aim of the present study was to contrast direct questioning of different types of PED use by Dutch fitness centre members with results obtained with the Randomized Response Technique (RRT). Questionnaires were conducted among members of fitness centres. PED were classified into the following categories: anabolic steroids, prohormones, substances to counteract side-effects, growth hormone and/or insulin, stimulants (to reduce weight), and miscellaneous substances. A total of 718 athletes from 92 fitness centres completed the questionnaire. The conventional method resulted in prevalences varying between 0% and 0.4% for the different types of PED with an overall prevalence of 0.4%. RRT resulted in prevalences varying between 0.8% and 4.8% for the different types of PED with an overall prevalence of 8.2%. The overall prevalence of the two survey methods differed significantly. The current study showed that the conventional survey method using direct questioning led to an underestimation of the prevalence. Based on the RRT results, the percentage of users of PED among members of fitness centres is approximately 8.2%. Stimulants to lose weight had the highest prevalence, even higher than anabolic steroids. The key task for future preventive health work is to not only focus on anabolic steroid use, but also include interventions focusing on the use of stimulants to lose weight. PMID:24019293

  2. Use of cohort data to estimate national prevalence of transmitted drug resistance to antiretroviral drugs in Spain (2007-2012).

    Science.gov (United States)

    Monge, S; Díez, M; Alvarez, M; Guillot, V; Iribarren, J A; Palacios, R; Delgado, R; Jaén, A; Blanco, J R; Domingo, P; Portilla, J; Pérez Elías, M J; Garcia, F

    2015-01-01

    Prevalence of transmitted drug resistance (pTDR) to antiretroviral drugs in Spain (2007-2012) was estimated using the CoRIS cohort, adjusting its territorial distribution and transmission route to the reference population from the Spanish Information System on New human immunodeficiency virus diagnoses. A total of 2702 patients from ten autonomous communities and with naive FASTA sequence within 6 months of human immunodeficiency virus diagnosis were selected. Weighted pTDR, estimated using the inverse probability of selection in the sample by autonomous communities and transmission group, was 8.12% (95% CI 6.44-9.80), not significantly different from unweighted pTDR. We illustrate how proportional weighting can maximize representativeness of cohort-based data, and its value to monitor pTDR at country level. PMID:25636937

  3. Prevalence

    Directory of Open Access Journals (Sweden)

    Mohammed Al-Darwish

    2014-07-01

    Conclusion: Results indicated that dental caries prevalence among school children in Qatar has reached critical levels, and is influenced by socio-demographic factors. The mean decayed, missing, and filled teeth values obtained in this study were the second highest detected in the Eastern Mediterranean region.

  4. [Prevalence of illicit drug use and associated factors during pregnancy in the BRISA cohort].

    Science.gov (United States)

    Rocha, Priscila Coimbra; Britto e Alves, Maria Teresa Seabra Soares de; Chagas, Deysianne Costa das; Silva, Antônio Augusto Moura da; Batista, Rosangela Fernandes Lucena; Silva, Raimundo Antonio da

    2016-01-01

    This study analyzes the prevalence of illicit drug use and associated factors during pregnancy. This was a cross-sectional study of participants in the BRISA prenatal care cohort. Frequencies and hierarchical logistic regression were used. Estimated prevalence rates were 1.45% for illicit drug use, 22.32% for alcohol consumption, and 4.22% for smoking. The study population was mostly young (81% in the 20-34-year bracket), with 9 to 11 years of schooling (75.55%), with more than half of the women outside the workforce (52.18%), and in economic class "C" (67.61%). Pregnant women showed a high level of stress (24.46%), moderate to intense anxiety (40.84%), and severe depressive symptoms (28.8%). Approximately half (49.72%) of the pregnant women reported some type of violence, and they had wide networks (72.77%) and low social support (65.21%). Use of legal drugs, high stress levels, and single parenthood were independently associated with illicit drug use in pregnancy. PMID:26886368

  5. Review of the prevalence and drug resistance of tuberculosis in prisons: a hidden epidemic.

    Science.gov (United States)

    Biadglegne, F; Rodloff, A C; Sack, U

    2015-04-01

    SUMMARY The prison setting has been often cited as a possible reservoir of tuberculosis (TB) including multidrug-resistant (MDR)-TB. This is particularly true in low-income, high TB prevalence countries in Sub-Saharan Africa. A systemic literature review was done to assess the prevalence, drug resistance and risk factors for acquiring TB in the prison population. Our review indicated a high prevalence of TB in prisons which is reported to be 3- to 1000-fold higher than that found in the civilian population, indicating evidence and the need for public health policy formulation. In addition, high levels of MDR and extensively drug-resistant (XDR)-TB have been reported from prisons, which is a warning call to review prison TB control strategy. Multiple risk factors such as overcrowding, poor ventilation, malnutrition, human immunodeficiency virus (HIV), and others have fuelled the spread of TB in prisons. Furthermore, the impact extends beyond the prison walls; it affects the civilian population, because family visits, prison staff, and members of the judiciary system could be potential portals of exit for TB transmission. The health of prisoners is a neglected political and scientific issue. Within these background conditions, it is suggested that political leaders and scientific communities should work together and give special attention to the control of TB and MDR-TB in prisons. If not, TB in prisons will remain a neglected global problem and threatens national and international TB control programmes. Further researches are required on the prevalence and drug resistance of smear-negative TB in prisons. In addition, evidence of the circulating strains and transmission dynamics inside prisons is also warranted. PMID:25376279

  6. Prevalence of HCV infection and associated factors among illicit drug users in Breves, State of Pará, northern Brazil

    Directory of Open Access Journals (Sweden)

    Suzy Danielly Barbosa Pacheco

    2014-06-01

    Full Text Available Introduction: Illicit drug users (DUs are vulnerable to hepatitis C virus (HCV infection. The shared use of illicit drugs is the main method of HCV transmission. Methods: A cross-sectional study was conducted in Breves, in northern Brazil. We surveyed 187 DUs to determine the prevalence of and factors associated with HCV infection. Results: The prevalence of anti-HCV antibodies was 36.9%, and the prevalence of hepatitis C virus-ribonucleic acid (HCV-RNA was 31%. Hepatitis C virus infection was associated with tattoos, intravenous drug use, shared use of equipment for drug use, drug use for longer than 3 years, and daily drug use. Conclusions: Strategies for preventing and controlling HCV transmission should be implemented among DUs.

  7. Prevalence

    OpenAIRE

    Mohammed Al-Darwish; Walid El Ansari; Abdulbari Bener

    2014-01-01

    Background: To ensure the oral health of a population, clinicians must deliver appropriate dental services, and local communities need to have access to dental care facilities. However, establishment of this infrastructure must be based on reliable information regarding disease prevalence and severity in the target population. Objectives: The aims of this study were to measure the incidence of dental caries in school children aged 12–14 throughout Qatar, including the influence of socio-de...

  8. Prevalence of medicinal drugs in suspected impaired drivers and a comparison with the use in the general Dutch population

    NARCIS (Netherlands)

    Bezemer, Karlijn D B; Smink, Beitske E; van Maanen, Rianne; Verschraagen, Miranda; de Gier, Johan J

    2014-01-01

    The aim of this study was to investigate the prevalence of psychotropic medicines in drivers suspected of driving under the influence of medicinal and illicit drugs in The Netherlands and to compare the prevalence of selected impairing medicines with the use of these medicines in the general Dutch p

  9. Prevalence of HIV and the risk behaviours among injecting drug users in Myanmar

    Directory of Open Access Journals (Sweden)

    Lin Aung Swe

    2012-01-01

    Full Text Available Background: Myanmar has one of the largest HIV positive populations in Asia and injecting drug use represents one of the major causes of HIV transmission.Aim: the aim of the study was to determine the prevalence of HIV and the risk behaviours among injecting drug users in Myanmar. Methods: A cross sectional study was designed to collect the data among injecting drug users enlisted in the state harm reduction programme in selected regions.Results: Of the 590 participants, 152 (25.8% were HIV positive. Female (OR 5.96. 95% CI 1.31;30.45, using ‘used syringes’ (OR 1.81. 95% CI 1.23;2.68 and sharing syringe when first used drugs (OR 2.98. 95% CI 2.00;4.44 and injecting drugs past six months (OR 3.36. 95% CI 1.50;6.15 were significant risk factors. Age (p=<0.001 and frequency of drug use per day (p=0.022 were also statistically significant. HIV positive IDUs were more likely to use disposable syringes (OR 3.0. 95% CI 1.50;6.15 and were less likely to share syringes (OR 3.41. 95% CI 1.71;6.96 during their last drug use. HIV positive IDUs were also more likely to check for VDRL (OR 1.89. 95% CI 1.26;2.84 and more likely to be VDRL positive (OR 1.90. 95% CI 1.11;3.26. Conclusion: HIV positive respondents used disposable syringes and few shared syringes the last time they injected drugs. This could probably be due to the education they received in the needle exchange programme centres.

  10. Cancer therapy disparity: unequal access to breast cancer therapeutics and drug funding in Canada

    OpenAIRE

    Verma, S.; Sehdev, S.; Joy, A.A.

    2007-01-01

    Adjuvant therapy has made a significant contribution in reducing breast cancer–specific mortality. Standard chemotherapeutics and tamoxifen have been the mainstay treatment for years, but recent clinical evidence supports the use of novel small-molecule therapy and aromatase inhibitor therapy in selected settings, challenging not only the traditional paradigm of breast cancer treatment, but also provincial funding of oncologic care across Canada. The disparity in access to aromatase inhibitor...

  11. Prevalence of and risk factors for asthma in off-reserve Aboriginal children and adults in Canada

    OpenAIRE

    Hsiu-Ju Chang; Jeremy Beach; Ambikaipakan Senthilselvan

    2012-01-01

    Only a few studies have investigated asthma morbidity in Canadian Aboriginal children. In the present study, data from the 2006 Aboriginal Peoples Survey were used to determine the prevalence and risk factors for asthma in Canadian Aboriginal children six to 14 years of age and adults 15 to 64 years of age living off reserve. The prevalence of asthma was 14.3% in children and 14.0% in adults. Children and adults with Inuit ancestry had a significantly lower prevalence of asthma than those wit...

  12. Short Communication: Prevalence of HIV Type 1 Transmitted Drug Resistance in Slovenia: 2005–2010

    OpenAIRE

    Lunar, Maja M.; Židovec Lepej, Snježana; Abecasis, Ana B; Tomažič, Janez; Vidmar, Ludvik; Karner, Primož; Vovko, Tomaž D.; Pečavar, Blaž; Maver, Polona J.; Seme, Katja; Poljak, Mario

    2013-01-01

    Slovenia is a small European country with a total of 547 HIV-infected individuals cumulatively reported by the end of 2011. However, the estimated incidence rate of HIV infections increased from 7.0 per million in 2003 to 26.8 per million in 2011. In this study, we assessed the prevalence of transmitted drug resistance (TDR) in the past 6 years (2005–2010) and analyzed the time trend of the proportion of men having sex with men (MSM) and HIV-1 subtype B among newly diagnosed individuals in a ...

  13. The politics behind the implementation of the WTO Paragraph 6 Decision in Canada to increase global drug access

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    Esmail Laura C

    2012-04-01

    Full Text Available Abstract Background The reform of pharmaceutical policy can often involve trade-offs between competing social and commercial goals. Canada's Access to Medicines Regime (CAMR, a legislative amendment that permits compulsory licensing for the production and export of medicines to developing countries, aimed to reconcile these goals. Since it was passed in 2004, only two orders of antiretroviral drugs, enough for 21,000 HIV/AIDS patients in Rwanda have been exported. Future use of the regime appears unlikely. This research aimed to examine the politics of CAMR. Methods Parliamentary Committee hearing transcripts from CAMR's legislative development (2004 and legislative review (2007 were analysed using a content analysis technique to identify how stakeholders who participated in the debates framed the issues. These findings were subsequently analysed using a framework of framing, institutions and interests to determine how these three dimensions shaped CAMR. Results In 2004, policy debates in Canada were dominated by two themes: intellectual property rights and the TRIPS Agreement. The right to medicines as a basic human right and CAMR's potential impact on innovation were hardly discussed. With the Departments of Industry Canada and International Trade as the lead institutions, the goals of protecting intellectual property and ensuring good trade relations with the United States appear to have taken priority over encouraging generic competition to achieve drug affordability. The result was a more limited interpretation of patent flexibilities under the WTO Paragraph 6 Decision. The most striking finding is the minimal discussion over the potential barriers developing country beneficiaries might face when attempting to use compulsory licensing, including their reluctance to use TRIPS flexibilities, their desire to pursue technological development and the constraints inherent in the WTO Paragraph 6 Decision. Instead, these issues were raised in 2007

  14. Use of Neuroenhancement Drugs: Prevalence, Frequency and Use Expectations in Switzerland

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    Stéphane Deline

    2014-03-01

    Full Text Available Objective: The present study investigates the use expectations, prevalence and frequency of neuroenhancement drug (ND use among the Swiss male population, separating college students from others. Methods: Young Swiss men were invited to participate in the Cohort Study on Substance Use Risk Factors. A total of 5,967 participants responded to questions on six types of NDs (wakefulness medication, antidepressants, Alzheimer’s disease medication, Parkinson’s disease medication, attention deficit-hyperactivity disorder (ADHD medication, and beta-blockers. The frequency of use depending on five expectations (to enhance wakefulness, attention, memory, concentration and stress reduction was analyzed for a twelve-month period. Results: (1 About 3% of the sample indicated use of at least one ND; (2 ADHD medication was the most prevalent; (3 The type of ND preferred differed depending on academic status (4. Quantitatively, over the year, college student users used ND much less frequently than other users. Conclusions: Prevalence of ND use is low in Switzerland relative to other countries such as the United States. Patterns of ND use differed depending on academic status, suggesting that while college student ND users tended to do so rarely (probably to enhance cognitive abilities for exams, non-college male users used other NDs more frequently (probably to “get high”.

  15. Prevalence of and Risk Factors for Asthma in Off-Reserve Aboriginal Children and Adults in Canada

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    Hsiu-Ju Chang

    2012-01-01

    Full Text Available Only a few studies have investigated asthma morbidity in Canadian Aboriginal children. In the present study, data from the 2006 Aboriginal Peoples Survey were used to determine the prevalence and risk factors for asthma in Canadian Aboriginal children six to 14 years of age and adults 15 to 64 years of age living off reserve. The prevalence of asthma was 14.3% in children and 14.0% in adults. Children and adults with Inuit ancestry had a significantly lower prevalence of asthma than those with North American Indian and Métis ancestries. Factors significantly associated with ever asthma in children included male sex, allergy, low birth weight, obesity, poor dwelling conditions and urban residence. In adults, factors associated with ever asthma varied among Aboriginal groups; however, age group, sex and urban residence were associated with ever asthma in all four Aboriginal groups. The prevalence of asthma was lower in Aboriginal children and higher in Aboriginal adults compared with that reported for the Canadian population. Variation in the prevalence of and risk factors for asthma among Aboriginal ancestry groups may be related to genetic and environmental factors that require further investigation.

  16. Prevalence of molecular markers of Plasmodium falciparum drug resistance in Dakar, Senegal

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    Wurtz Nathalie

    2012-06-01

    Full Text Available Abstract Background As a result of the widespread resistance to chloroquine and sulphadoxine-pyrimethamine, artemisinin-based combination therapy (ACT (including artemether-lumefantrine and artesunate-amodiaquine has been recommended as a first-line anti-malarial regimen in Senegal since 2006. Intermittent preventive treatments with anti-malarial drugs based on sulphadoxine-pyrimethamine are also given to children or pregnant women once per month during the transmission season. Since 2006, there have been very few reports on the susceptibility of Plasmodium falciparum to anti-malarial drugs. To estimate the prevalence of resistance to several anti-malarial drugs since the introduction of the widespread use of ACT, the presence of molecular markers associated with resistance to chloroquine and sulphadoxine-pyrimethamine was assessed in local isolates at the military hospital of Dakar. Methods The prevalence of genetic polymorphisms in genes associated with anti-malarial drug resistance, i.e., Pfcrt, Pfdhfr, Pfdhps and Pfmdr1, and the copy number of Pfmdr1 were evaluated for a panel of 174 isolates collected from patients recruited at the military hospital of Dakar from 14 October 2009 to 19 January 2010. Results The Pfcrt 76T mutation was identified in 37.2% of the samples. The Pfmdr1 86Y and 184F mutations were found in 16.6% and 67.6% of the tested samples, respectively. Twenty-eight of the 29 isolates with the 86Y mutation were also mutated at codon 184. Only one isolate (0.6% had two copies of Pfmdr1. The Pfdhfr 108N/T, 51I and 59R mutations were identified in 82.4%, 83.5% and 74.1% of the samples, respectively. The double mutant (108N and 51I was detected in 83.5% of the isolates, and the triple mutant (108N, 51I and 59R was detected in 75.3%. The Pfdhps 437G, 436F/A and 613S mutations were found in 40.2%, 35.1% and 1.8% of the samples, respectively. There was no double mutant (437G and 540E or no quintuple mutant (Pfdhfr 108N, 51I and 59R

  17. Potential drug interactions and duplicate prescriptions among ambulatory cancer patients: a prevalence study using an advanced screening method

    OpenAIRE

    Schuitenmaker Martin S; Boom Frits A; Swart Eleonora L; van Leeuwen Roelof WF; Hugtenburg Jacqueline G

    2010-01-01

    Abstract Background The pharmacotherapeutic treatment of patients with cancer is generally associated with multiple side-effects. Drug interactions and duplicate prescriptions between anti-cancer drugs or interactions with medication to treat comorbidity can reinforce or intensify side-effects. The aim of the present study is to gain more insight into the prevalence of drug interactions and duplicate prescriptions among patients being treated in the outpatient day care departments for oncolog...

  18. High prevalence of psychotropic drug use among persons with and without Alzheimer's disease in Finnish nationwide cohort.

    Science.gov (United States)

    Taipale, Heidi; Koponen, Marjaana; Tanskanen, Antti; Tolppanen, Anna-Maija; Tiihonen, Jari; Hartikainen, Sirpa

    2014-11-01

    Psychotropic drugs are used for treatment of behavioral and psychological symptoms of dementia (BPSD) although they are associated with serious adverse drug events. Objective of our study was to investigate prevalence of psychotropic drug use one year after diagnoses of Alzheimer's disease (AD), to compare prevalence to persons without AD and to assess changes in prevalence over time. Data from the MEDALZ (Medication use and Alzheimer's disease) cohort was utilized in the study including all 69,080 community-dwelling persons with new diagnosis of AD during years 2005-2011 in Finland. Four age-, gender- and region of residence-matched persons without AD were identified for each case. Register-based data included prescription drug purchases and comorbidities from Special Reimbursement Register. Annual prevalence of psychotropic drug use one year after diagnosis was determined for each person. Psychotropic drugs were used by 53% of persons with AD compared with 33% of persons without AD during one year after diagnoses. Persons with AD were six times more likely to use antipsychotics and three times more likely to use antidepressants whereas benzodiazepine and related drug (BZDR) use was comparable between persons with and without AD. According to year of AD diagnoses during 2005-2011, antipsychotic use increased from 18% to 20% (pBPSD, antipsychotic use increased from 2005 to 2011 among newly diagnosed persons with AD in Finland. PMID:25453487

  19. Prevalence and Drug Consumption Habits at the 2011 Peninsula Festival in Tîrgu Mureș

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    L Domokos

    2013-08-01

    Full Text Available Introduction: In 2010 Romania was ranked fourth in the European Union regarding the prevalence of ethnobotanical drug use with psychotropic effect. The main purpose of our survey was to collect data on substance use and assess drug consumption habits among participants at the 2011 Peninsula Music Festival in Tîrgu Mureș, Romania. Material and method: The study was carried out as a cross-sectional survey in a sample of 256 persons, using an anonymous, self-administered structured questionnaire, containing questions about the consumption patterns of illegal psychoactive drugs, as well as sociodemographic data which could influence drug consumption (age, gender, educational level, marital status of parents. Results: Ethnobotanical drug consumption had the highest lifetime prevalence (37.7%, the second most often used drug was cannabis (marijuana with a lifetime prevalence of 35.2%. Males and females differed significantly in the use of marijuana (p = 0.023 and ethnobotanical drugs (p = 0.008 in the last 12 months, male respondents used more of these psychoactive substances. In the case of children with divorced parents the last 12 months marijuana use (p = 0.032 and ethnobotanical drug use (p = 0.013 was significantly higher than in the case of children whose parents were not divorced. Conclusions: The survey results show the importance of the development of health education programs and drug-prevention strategies for vulnerable goups (festival visitors, minors, children with divorced parents

  20. Prevalence and Risk Factors of Hepatitis B Infection in Injection Drug Users, Tehran (2001-2002

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    Hamid Tavakkoli

    2008-02-01

    Full Text Available Background and Aims: Hepatitis B virus (HBV infection has a high incidence among injection drug users (IDUs. Several important behavioral risk factors influence transmission of HBV in this group. However, consensus has not been achieved on many of them. The aim of this investigation was to assess the prevalence and risk factors for HBV in IDUs. Methods: This cross-sectional study was carried out between 2001 and 2002 in Tehran. IDUs included people who were being treated for drug abuse and those in the prison. Physician-completed risk factor questionnaires and blood samples (5 ml for serologic HBV markers (ELISA were used. Risk factors were evaluated in binary logistic regression (LR model (forward procedure for possible association with odds of past or current HBV infection. The evaluated risk factors were age, gender, sexual behavior, shared syringe use, duration of addiction, imprisonment, tattooing, past history of surgery, dental procedures, blood transfusion, jaundice, type of illicit drug use and level of education.Results: This study sample was comprised of 518 IDUs (89.6% males, including 386 (74.5% prisoners. Antibody against HBV core antigen (HBcAb was detected in 61.2% (n=317. The prevalence of hepatitis B surface antigen (HBsAg was 3.7% (n=19. Among HBsAg positive patients, HBeAg was positive in 12 individuals (63.2%. In comparison with seronegative IDUs for HBcAb and/or HBsAg, the odds of using shared syringes, male sex and past history of bisexual relationship were 1.5 (P<0.05, 1.9 (P<0.05 and 2.4 (P<0.01, respectively.Conclusions: These results suggest that seroprevalence of hepatitis B is high but chronic carrier state is not frequent in IDUs. Imprisonment, male sex and having past history of bisexual relationship are independent risk factors for past or current hepatitis B infection.

  1. Prevalence and type of drug-drug interactions involving antiretrovirals in patients attending a specialist outpatient clinic in Kampala, Uganda

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    K Seden

    2012-11-01

    Full Text Available Scale-up of HIV services in countries such as Uganda has resulted in a rapid increase in facilities offering antiretrovirals (ARVs and an increase in healthcare workers trained to deliver care. Consequently, evaluating medication safety is increasingly important in these settings. Data from developed countries suggest that drug-drug interactions (DDIs involving ARVs are common, occurring at rates of 14–58%. Few data are available from low resource settings, however a study of 996 Kenyan patients found that 33.5% were at risk of clinically significant DDIs. We evaluated the prevalence and type of ARV DDIs and the patients most at risk in an African outpatient setting. A random sample of patients taking current ARVs and accessing care at the Infectious Diseases Institute, Makerere University, Kampala was selected from the clinic database. The most recent prescription for each patient was screened for DDIs using www.hiv-druginteractions.org. Clinical significance of DDIs was assessed by two of us using a previously developed technique evaluating: likelihood of interaction, therapeutic index of affected drug and severity of potential adverse effect. From 1000 consecutive patients 99.6% were taking≥1 co-medication alongside their ARV regimen (mean 1.89. 24.5% had≥1 potential DDI, with a total of 335 DDIs observed. Of these, 255 DDIs were considered clinically significant, affecting 18.8% of patients. Only 0.3% of DDIs involved a contraindicated combination. There was a higher rate of potential DDIs observed in patients taking TB treatment (p=0.0047, who were WHO stage 3 or 4 (p=0.001, or patients taking ≥2 co-medications alongside ARVs (p<0.0001 (Fishers exact test. Patient age, gender, CD4 count and weight did not affect risk for DDIs. Co-medications commonly associated with potential DDIs were antibiotics (6.2% of 1000 patients, anthelminthics (4.6% and antifungals (3.5%. Potential DDIs involving ARVs occur at similar rates in resource

  2. The relative risks and etiologic fractions of different causes of death and disease attributable to alcohol, tobacco and illicit drug use in Canada

    OpenAIRE

    Single, E; Rehm, J.; Robson, L; Truong, M V

    2000-01-01

    BACKGROUND: In 1996 the number of deaths and admissions to hospital in Canada that could be attributed to the use of alcohol, tobacco and illicit drugs were estimated from 1992 data. In this paper we update these estimates to the year 1995. METHODS: On the basis of pooled estimates of relative risk, etiologic fractions were calculated by age, sex and province for 90 causes of disease or death attributable to alcohol, tobacco or illicit drugs; the etiologic fractions were then applied to natio...

  3. Guidance for Practitioners on the Use of Antiviral Drugs to Control Influenza Outbreaks in Long-Term Care Facilities in Canada, 2014-2015 Season

    OpenAIRE

    Fred Y Aoki; Allen, Upton D.; H Grant Stiver; Michel Laverdière; Danuta Skowronski; Evans, Gerald A

    2015-01-01

    The AMMI Canada Guidelines document ‘The use of antiviral drugs for influenza: A foundation document for practitioners’, published in the Autumn 2013 issue of the Journal, outlines the recommendations for the use of antiviral drugs to treat influenza. This article, which represents the first of two updates to these guidelines published in the current issue of the Journal, aims to inform health care professionals of the increased risk for influenza in long-term care facilities due to a documen...

  4. Time required for approval of new drugs in Canada, Australia, Sweden, the United Kingdom and the United States in 1996-1998

    OpenAIRE

    Rawson, N S

    2000-01-01

    BACKGROUND: The timeliness with which national regulatory agencies approve new drugs for marketing affects health care professionals and patients. An unnecessarily long approval process delays access to new medications that may improve patients' health status. The author compared drug approval times in Canada, Australia, Sweden, the United Kingdom and the United States. METHODS: Application and approval dates of new chemical or biological substances (excluding diagnostic products, and new sal...

  5. Strategies for the detection of drugs within the Correctional Service Canada: research and development initiatives

    Science.gov (United States)

    Roberts, Jim E.; Rochefort, Joe

    1997-02-01

    Within correctional facilities, the use and abuse of intoxicants, often leads to and results in, very serious incidents such as staff assaults, inmate assaults, murders, riots, hostage taking, deaths by drug overdose and suicides. Needless to say, these types of violent activities undermine the safety and security of our prison system, and undermine the successful reintegration of the offender back into society as the offender will be released with the same drug abuse problems that led him or her to the prison system in the first instance. In addition, without the use of reliable drug detection technologies to assist our correctional officers in conducting search and seizure, our efforts to better secure the prison environment would be severely hampered. We believe that as a member of the law enforcement community at large and, in view of our mandate to protect society, we have a legal duty to control and to seize any drugs and related contraband illegally entering our federal correctional facilities. In addition, we have a lawful duty to detect and seize drugs that are already in circulation within our correctional environment. To this end, a pilot project utilizing an Ion Mobility Spectrometry and an Ion Mobility Trap Spectrometry scanner, has aided our efforts and has resulted in an apparent reduction in drug related activities within Canadian prisons. These efforts also promote offender treatment and rehabilitative programs within our Service and better protects the public at large.

  6. The Prevalence of Tobacco, Hubble-Bubble, Alcoholic Drinks, Drugs, and Stimulants among High-School Students

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    Roghayeh Alaee

    2011-08-01

    Full Text Available Introduction: The purpose of the present study was to investigate the prevalence of tobacco, hubble-bubble, alcoholic drinks, and other drugs among Karaj high-school students in 2011. Methods: The research method was a descriptive-sectional study. Participants of this study were 447 girl and boy high-school students of Karaj that were selected by clustering random sampling. For data gathering, drug abuse questionnaire, and risk and protective factors inventory were administered among selected sample. Results: According to the results, 57% of students in this study said that they have had experiences with a kind of drug including tobacco, hubble-bubble, alcoholic drinks, and other drugs at least once in their lives. The study showed the prevalence for soft drugs: hubble-bubble, tobacco, and alcoholic drinks, and for hard drugs ecstasy, opium, hashish, meth, crack, and heroin respectively. Conclusion: Soft drugs including hubble-bubble, tobacco, and alcoholic drinks, are the most common among Karaj high-school students. The prevalence of hard drugs among them is rather low.

  7. Prevalence of texting while driving and other risky driving behaviors among young people in Ontario, Canada: Evidence from 2012 and 2014.

    Science.gov (United States)

    Tucker, Sean; Pek, Simon; Morrish, Jayne; Ruf, Megan

    2015-11-01

    This paper reports on the prevalence of texting while driving and other risky driving behaviors by age and gender in two large samples of youth aged 16-19 years in Ontario, Canada. In Study 1 (N=6133), we found that males reported more frequent texting while driving and speeding than females and, in terms of age, sixteen year olds reported frequent texting while driving than older participants. In Study 2 (N=4450), which was conducted two years later, males again reported more frequent texting while driving, however there was no difference in the rate of talking on the phone while driving among males and females. Participants also reported on experiences that led to a significant reduction in their texting while driving. The most common reasons were the perceived danger of texting while driving, laws and fines against texting while driving, and observing close-calls and accidents experienced by other people. The results of both studies suggest that driving-related risk-taking behaviors co-occur and that young passengers in vehicles, including 14 and 15 year olds, are bystanders to texting while driving. Finally, there was a substantial decline in the prevalence of texting while driving across the studies. In Study 1, 27% of participants reported "sometimes" to "almost always" texting while driving compared to 6% of participants in Study 2. Limitations and implications for public campaigns targeted youth distracted driving are discussed. PMID:26344898

  8. Population structure and drug resistance patterns of emerging non-PCV-13 Streptococcus pneumoniae serotypes 22F, 15A, and 8 isolated from adults in Ontario, Canada.

    Science.gov (United States)

    Duvvuri, Venkata R; Deng, Xianding; Teatero, Sarah; Memari, Nader; Athey, Taryn; Fittipaldi, Nahuel; Gubbay, Jonathan B

    2016-08-01

    The introduction of pneumococcal conjugate vaccines has led to the emergence of non-vaccine serotypes, which contributed to invasive pneumococcal disease in Canada and worldwide. A significant increase in the prevalence of non-13-valent pneumococcal conjugate vaccine (PCV-13)-included serotypes 22F, 15A, and 8 was observed from 2009 to 2013 in Ontario (all p valuesStreptococcus pneumoniae population structures and dynamics, and its utility in molecular surveillance. PMID:27071529

  9. The Prevalence of Cardiac Risk Factors in Men with Localized Prostate Cancer Undergoing Androgen Deprivation Therapy in British Columbia, Canada

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    Margot K. Davis

    2015-01-01

    Full Text Available Background. While androgen deprivation therapy (ADT reduces the risk of prostate cancer-specific mortality in high-risk localized prostate cancer, it adversely affects cardiovascular (CV risk factor profiles in treated men. Methods. We retrospectively reviewed the charts of 100 consecutive men with intermediate- or high-risk localized prostate cancer referred to the British Columbia Cancer Agency for ADT. Data on CV risk factors and disease were collected and Framingham risk scores were calculated. Results. The median age of the study cohort was 73 years. Established cardiovascular disease was present in 25% of patients. Among patients without established CV disease, calculated Framingham risk was high in 65%, intermediate in 33%, and low in 1%. Baseline hypertension was present in 58% of patients, dyslipidemia in 51%, and diabetes or impaired glucose tolerance in 24%. Hypertension was more prevalent in the study cohort than in an age- and sex-matched population sample (OR 1.74, P=0.006; diabetes had a similar prevalence (OR 0.93, P=0.8. Conclusions. Patients receiving ADT have a high prevalence of cardiovascular disease and risk factors and are more likely to be hypertensive than population controls. Low rates of CV risk screening suggest opportunities for improved primary and secondary prevention of CV disease in this population.

  10. High prevalence of childhood multi-drug resistant tuberculosis in Johannesburg, South Africa: a cross sectional study

    OpenAIRE

    Beylis Natalie C; Fairlie Lee; Reubenson Gary; Moore David P; Madhi Shabir A

    2011-01-01

    Abstract Background There are limited data on the prevalence of multi-drug resistant tuberculosis (MDR-TB), estimated at 0.6-6.7%, in African children with tuberculosis. We undertook a retrospective analysis of the prevalence of MDR-TB in children with Mycobacterium tuberculosis (MTB) at two hospitals in Johannesburg, South Africa. Methods Culture-confirmed cases of MTB in children under 14 years, attending two academic hospitals in Johannesburg, South Africa during 2008 were identified and h...

  11. Utilização de medicamentos em adultos: prevalência e determinantes individuais Drug utilization in adults: prevalence and individuals determinants

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    Andréa D Bertoldi

    2004-04-01

    Full Text Available OBJETIVO: Estudar os padrões de utilização de medicamentos, classificando-os por grupos farmacológicos e verificando os determinantes individuais desse uso. MÉTODOS: Delineamento transversal de base populacional. Amostra composta por 3.182 indivíduos com 20 anos de idade ou mais, residentes na região urbana do município de Pelotas, RS. O processo de amostragem foi conduzido em múltiplos estágios. O instrumento foi um questionário estruturado, utilizando um período recordatório de 15 dias e aplicado através de entrevistas individuais. Na análise bruta, foram utilizados os seguintes testes: qui-quadrado para comparação de proporções, teste t para comparação de médias e o teste de tendência linear. A análise ajustada foi conduzida através de uma regressão de Poisson. RESULTADOS: A prevalência de uso global de medicamentos foi de 65,9%. Os seguintes grupos apresentaram maiores prevalências de utilização de medicamentos após análise ajustada: mulheres, idosos, indivíduos de nível econômico mais elevado e com pior autopercepção de saúde. Os grupos farmacológicos mais utilizados foram os analgésicos, antiinflamatórios e anti-hipertensivos. CONCLUSÕES: A prevalência de uso de medicamentos foi superior às encontradas em outros estudos nacionais e internacionais. O estudo dos determinantes individuais de utilização de medicamentos indica os grupos mais sujeitos ao uso excessivo, o que pode embasar estratégias específicas para diminuir a utilização nesses grupos, tais como políticas mais restritivas para prescrição e venda de medicamentos.OBJECTIVE: To study epidemiological patterns of drug utilization and its individual determinants and to classify drugs used into pharmacological groups. METHODS: In a population-based cross-sectional study, 3,182 subjects aged 20 years or more were selected from an urban area in Southern Brazil using a multi-stage sampling design. Data were collected through home

  12. Prevalence and correlates of neck injection among people who inject drugs in Tijuana, Mexico

    Science.gov (United States)

    RAFFUL, CLAUDIA; WAGNER, KARLA D.; WERB, DAN; GONZÁLEZ-ZÚÑIGA, PATRICIA E.; VERDUGO, SILVIA; RANGEL, GUDELIA; STRATHDEE, STEFFANIE A.

    2016-01-01

    Introduction and Aims Injecting drugs in the neck has been related to adverse health conditions such as jugular vein thrombosis, deep neck infections, aneurysm, haematomas, airway obstruction, vocal cord paralysis and wound botulism, among others. We identified prevalence and correlates of neck injection among people who inject drugs (PWID) in Tijuana, Mexico. Design and Methods Beginning in 2011, PWID aged ≥18 years who injected drugs within the last month were recruited into a prospective cohort. At baseline and semi-annually, PWID completed interviewer-administered surveys soliciting data on drug-injecting practices. Logistic regression was used to identify predictors of injecting in the neck as the most frequent injection site at a single visit. Results Of 380 PWID, 35.3% injected in the neck at least once in the past 6 months, among whom 71.6% reported it as their most common injection site, the most common injecting site after the arms (47%). Controlling for age, years injecting and injecting frequency, injecting heroin and methamphetamine two or more times per day and having sought injection assistance were associated with injecting in the neck [adjusted odds ratios (AOR): 2.12; 95% confidence intervals (CI): 1.27–3.53 and AOR: 2.65; 95% CI: 1.52–4.53 respectively]. Discussion and Conclusions Injecting in the neck was very common among PWID in Tijuana and was associated with polydrug use and seeking injection assistance. Tailoring harm reduction education interventions for individuals who provide injection assistance (‘hit doctors’) may allow for the dissemination of safe injecting knowledge to reduce injection-related morbidity and mortality. PMID:25867795

  13. PREVALENCE OF DRUG-RESISTANT STRAINS OF STREPTOCOCCUS PNEUMONIAE IN ABAKALIKI

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    Iroha Ifeanyichukwu Romanus

    2012-01-01

    Full Text Available Streptococcus pneumoniae is a major cause of illness such as pneumonia, meningitis, bacteremia and otitis media in children and the elderly. The emergence of drug-resistant strains threatens to complicate the management of these diseases. We conducted a hospital-based surveillance for drug-resistant Strep. Pneumoniae in outpatients with pneumococcal infection in Abakaliki Ebonyi State Nigeria. Between 2003-2005 from January through December, a cross-sectional study was conducted in Ebonyi State University Teaching Hospital (EBSUTH Abakaliki to assess the prevalence of drug resistant strains of Streptococcus pneumoniae isolated from sputum samples of patients with pneumococcal infections attending the outpatient clinics. A total of 305 sputum samples of patients with clinically diagnosed pneumonia were collected and inoculated on 5% sheep-blood agar, incubated at 35°C for 24 h in 5-10% CO2. Colonies were Gram-stained; alpha-hemolysis colonies were tested with a 6mm optochin disk followed by bile solubility test. Susceptibility testing panels of the following antibiotics: penicillin, ciprofloxacin, clavulanic acid/amoxicillin, septrin, erythromycin, gentamycin, clarithromycin, cefotaxime and cefuroxime were tested against isolated strains of Streptococcus pneumoniae using disc diffusion method. Of the 305 sputum samples collected 30 (9.8% of S. pneumoniae was isolated from patients within the age range of 20-40 years, 140 (45.9% from patients within 41-60, 135(44.2% from patients within 60 years and above. Susceptibility studies showed that the highest resistance was 182 (59.6%, for penicillin followed by septrin 156 (51.2%, erythromycin 120(39.3%, clavulanic/amoxicillin 118(38.7% cefotaxime 114(37.4% clarithromycin 100(32.7%, ciprofloxacin 94(30.8%, gentamycin 75(24.6%, cefuroxime 70(22.9% and ceftriaxone 69(22.6%. The prevalence of S. pneumoniae resistance was relatively high and we suggest that proper antibiotics use should be adopted to avert

  14. Prevalence of oral lesions among HIV-infected intravenous drug abusers and other risk groups.

    Science.gov (United States)

    Barone, R; Ficarra, G; Gaglioti, D; Orsi, A; Mazzotta, F

    1990-02-01

    To study the prevalence of oral manifestations, we examined 217 patients infected with the human immunodeficiency virus (HIV). Most of our patients were intravenous drug abusers (IVDAs) (65%). Other risk categories were represented by IVDAs who were also male homosexuals or bisexuals (11%), male homosexuals and bisexuals (16%), sexual partners of HIV-infected patients (5%), and hemophilic persons and recipients of blood transfusions (3%). Forty-six patients were women and 171 were men, with a median age of 27 years (range, 11 to 65 years). At the time of first examination, 38% of patients had asymptomatic HIV infection, 36% had lymphadenopathy syndrome, 17% had AIDS-related complex, and 9% had AIDS. Oral manifestations were observed in 89 (41%) patients. Of these, 15 had asymptomatic infection, 23 had lymphadenopathy syndrome, 27 had AIDS-related complex, and 24 had AIDS. Increasing severity of disease was significantly associated with higher prevalence of oral lesions (p less than or equal to 0.0001). Candidiasis was the most common oral lesion, followed by hairy leukoplakia. Kaposi's sarcoma, melanotic macules, herpes labialis, condyloma acuminatum, perioral molluscum contagiosum, and bacterial glossitis due to Escherichia coli infection were found in a small number of patients. Results of culture for fungi, available for 203 patients, revealed that 51% of patients with positive Candida cultures had clinical evidence of candidiasis. Our study demonstrates that oral lesions are also important signs of HIV infection among IVDAs. Early diagnosis of these manifestations is becoming increasingly significant in the practice of dentistry. PMID:2304743

  15. Prevalence and perceived preventability of self-reported adverse drug events--a population-based survey of 7099 adults.

    Directory of Open Access Journals (Sweden)

    Katja Marja Hakkarainen

    Full Text Available PURPOSE: Adverse drug events (ADEs are common and often preventable among inpatients, but self-reported ADEs have not been investigated in a representative sample of the general public. The objectives of this study were to estimate the 1-month prevalence of self-reported ADEs among the adult general public, and the perceived preventability of 2 ADE categories: adverse drug reactions (ADRs and sub-therapeutic effects (STEs. METHODS: In this cross-sectional study, a postal survey was sent in October 2010 to a random sample of 13 931 Swedish residents aged ≥ 18 years. Self-reported ADEs experienced during the past month included ADRs, STEs, drug dependence, drug intoxications and morbidity due to drug-related untreated indication. ADEs could be associated with prescription, non-prescription or herbal drugs. The respondents estimated whether ADRs and STEs could have been prevented. ADE prevalences in age groups (18-44, 45-64, or ≥65 years were compared. RESULTS: Of 7099 respondents (response rate 51.0%, ADEs were reported by 19.4% (95% confidence interval, 18.5-20.3%, and the prevalence did not differ by age group (p>0.05. The prevalences of self-reported ADRs, STEs, and morbidities due to drug-related untreated indications were 7.8% (7.2-8.4%, 7.6% (7.0-8.2% and 8.1% (7.5-8.7%, respectively. The prevalence of self-reported drug dependence was 2.2% (1.9-2.6%, and drug intoxications 0.2% (0.1-0.3%. The respondents considered 19.2% (14.8-23.6% of ADRs and STEs preventable. Although reported drugs varied between ADE categories, most ADEs were attributable to commonly dispensed drugs. Drugs reported for all and preventable events were similar. CONCLUSIONS: One-fifth of the adult general public across age groups reported ADEs during the past month, indicating a need for prevention strategies beyond hospitalised patients. For this, the underlying causes of ADEs should increasingly be investigated. The high burden of ADEs and preventable ADEs from

  16. Prevalence and Perceived Preventability of Self-Reported Adverse Drug Events – A Population-Based Survey of 7099 Adults

    Science.gov (United States)

    Hakkarainen, Katja Marja; Andersson Sundell, Karolina; Petzold, Max; Hägg, Staffan

    2013-01-01

    Purpose Adverse drug events (ADEs) are common and often preventable among inpatients, but self-reported ADEs have not been investigated in a representative sample of the general public. The objectives of this study were to estimate the 1-month prevalence of self-reported ADEs among the adult general public, and the perceived preventability of 2 ADE categories: adverse drug reactions (ADRs) and sub-therapeutic effects (STEs). Methods In this cross-sectional study, a postal survey was sent in October 2010 to a random sample of 13 931 Swedish residents aged ≥18 years. Self-reported ADEs experienced during the past month included ADRs, STEs, drug dependence, drug intoxications and morbidity due to drug-related untreated indication. ADEs could be associated with prescription, non-prescription or herbal drugs. The respondents estimated whether ADRs and STEs could have been prevented. ADE prevalences in age groups (18–44, 45–64, or ≥65 years) were compared. Results Of 7099 respondents (response rate 51.0%), ADEs were reported by 19.4% (95% confidence interval, 18.5–20.3%), and the prevalence did not differ by age group (p>0.05). The prevalences of self-reported ADRs, STEs, and morbidities due to drug-related untreated indications were 7.8% (7.2–8.4%), 7.6% (7.0–8.2%) and 8.1% (7.5–8.7%), respectively. The prevalence of self-reported drug dependence was 2.2% (1.9–2.6%), and drug intoxications 0.2% (0.1–0.3%). The respondents considered 19.2% (14.8–23.6%) of ADRs and STEs preventable. Although reported drugs varied between ADE categories, most ADEs were attributable to commonly dispensed drugs. Drugs reported for all and preventable events were similar. Conclusions One-fifth of the adult general public across age groups reported ADEs during the past month, indicating a need for prevention strategies beyond hospitalised patients. For this, the underlying causes of ADEs should increasingly be investigated. The high burden of ADEs and preventable ADEs

  17. Prevalence, nature and potential preventability of adverse drug events – a population-based medical record study of 4970 adults

    Science.gov (United States)

    Hakkarainen, Katja M; Gyllensten, Hanna; Jönsson, Anna K; Andersson Sundell, Karolina; Petzold, Max; Hägg, Staffan

    2014-01-01

    Aims To estimate the 3 month prevalence of adverse drug events (ADEs), categories of ADEs and preventable ADEs, and the preventability of ADEs among adults in Sweden. Further, to identify drug classes and organ systems associated with ADEs and estimate their seriousness. Methods A random sample of 5025 adults in a Swedish county council in 2008 was drawn from the Total Population Register. All their medical records in 29 inpatient care departments in three hospitals, 110 specialized outpatient clinics and 51 primary care units were reviewed retrospectively in a stepwise manner, and complemented with register data on dispensed drugs. ADEs, including adverse drug reactions (ADRs), sub-therapeutic effects of drug therapy (STEs), drug dependence and abuse, drug intoxications from overdose, and morbidities due to drug-related untreated indication, were detected during a 3 month study period, and assessed for preventability. Results Among 4970 included individuals, the prevalence of ADEs was 12.0% (95% confidence interval (CI) 11.1, 12.9%), and preventable ADEs 5.6% (95% CI 5.0, 6.2%). ADRs (6.9%; 95% CI 6.2, 7.6%) and STEs (6.4%; 95% CI 5.8, 7.1%) were more prevalent than the other ADEs. Of the ADEs, 38.8% (95% CI 35.8–41.9%) was preventable, varying by ADE category and seriousness. ADEs were frequently associated with nervous system and cardiovascular drugs, but the associated drugs and affected organs varied by ADE category. Conclusions The considerable burden of ADEs and preventable ADEs from commonly used drugs across care settings warrants large-scale efforts to redesign safer, higher quality healthcare systems. The heterogeneous nature of the ADE categories should be considered in research and clinical practice for preventing, detecting and mitigating ADEs. PMID:24372506

  18. Prevalence of Transmitted Drug Resistance Mutations in HIV-1-Infected Drug-Naive Patients from Urban and Suburban Regions of Kenya.

    Science.gov (United States)

    Onsongo, Simon; Abidi, Syed Hani; Khamadi, Samoel; Shah, Reena; Kageha, Sheila; Ojwang, Peter; Ali, Syed; Okinda, Nancy

    2016-03-01

    HIV was first described in Kenya in 1984-1985. Currently, Kenya has an estimated HIV-1 prevalence of 6.2%. With the introduction of antiretroviral drugs, the survival of most HIV patients has been prolonged markedly. However, this is greatly threatened by increasing rates of antiretroviral dug resistance, which may eventually lead to suboptimal treatment outcomes. The objective of this study was to characterize currently occurring antiretroviral drug resistance mutations among drug-naive patients visiting two referral hospitals in Kenya. Using polymerase chain reaction, the HIV protease gene was amplified from blood samples of 63 study participants. The sequences were used to determine HIV-1 subtype and presence/prevalence of mutations associated with resistance to protease inhibitors. Finally, the protease gene was variably measured using Shannon entropy analysis. Analysis of frequency of HIV-1 subtypes revealed subtype A to be the predominant subtype, while the analysis of drug resistance mutations revealed the presence of four minor drug resistance mutations associated weakly with resistance to protease inhibitors. Among these mutations, L33I was the most prevalent mutation. Shannon entropy analysis revealed high genomic variability, especially in region spanning nucleotides 1-55, 113-170, and 205-240. This study warrants the need for dedicated efforts to improve compliance to antiretroviral therapy and reduce transmitted resistance rates, which will greatly ensure the therapeutic efficacy of antiretroviral drugs. PMID:26401720

  19. Prevalence of G6PD deficiency versus oxidizing drugs: a survey in the tertiary care hospital

    Directory of Open Access Journals (Sweden)

    Rakesh R. Pathak

    2013-04-01

    Full Text Available Background: G6PD deficiency is distributed worldwide including India and is involved in accidental hemolysis and anemia by inadvertent use of oxidizing drugs. Awareness of community wise occurrence of G6PD deficiency can help in screening beforehand. Methods: On 150 community wise classified, non-anemic, non- hemolysed (in recent past visitors of pathological laboratory attached to C U Shah Medical College, Surendranagar, Gujarat, Crayman’s hemoglobin colorimetric kit (item no 700540 was used to estimate normal or below normal status of G6PD. Results: 10 people (6.6% of population were found deficient – 7 (4 male + 3 female from Harijan community, 2 (1 male + 1 female from Rabbari community and 1 (1 male + 0 female from Lohana community. Conclusions: While applying oxidizing drugs in a person of Harijan community (prevalence 7 out of total 26, i.e. 27%, extra caution is required, esp. if a person otherwise vulnerable (e.g. alcoholic. For other less represented communities, larger stratified sampling is required. [Int J Basic Clin Pharmacol 2013; 2(2.000: 170-176

  20. Prevalence and Drug Consumption Habits at the 2011 Peninsula Festival in Tîrgu Mureș

    OpenAIRE

    L Domokos; Ábrám, Z.; Sz Sebesi; Hajnal Finta

    2013-01-01

    Introduction: In 2010 Romania was ranked fourth in the European Union regarding the prevalence of ethnobotanical drug use with psychotropic effect. The main purpose of our survey was to collect data on substance use and assess drug consumption habits among participants at the 2011 Peninsula Music Festival in Tîrgu Mureș, Romania. Material and method: The study was carried out as a cross-sectional survey in a sample of 256 persons, using an anonymous, self-administered structured questionnaire...

  1. Illicit use of opioid substitution drugs: Prevalence, user characteristics, and the association with non-fatal overdoses

    OpenAIRE

    Bretteville-Jensen, Anne Line; Lillehagen, Mats; Gjersing, Linn Renathe; Andreas, Jasmina Burdzovic

    2014-01-01

    Diversion of opioid substitution drugs (OSD) is of public concern. This study examined the prevalence, frequency, and predictors of illicit OSD use in a group of injecting drug users (IDUs) and assessed if such use was associated with non-fatal overdoses. Semi-annual cross-sectional interviews conducted in Oslo, Norway (2006–2013), from 1355 street-recruited IDUs. Hurdle, logistic, and multinomial regression models were employed. Overall, 27% reported illicit OSD use in the past four we...

  2. Prevalence of multi-drug resistant uropathogenic Escherichia coli in Potohar region of Pakistan

    Institute of Scientific and Technical Information of China (English)

    Ihsan Ali; Zara Rafaque; Safia Ahmed; Sajid Malik; Javid Iqbal Dasti

    2016-01-01

    Objective: To scrutinize patterns of multi-drug-resistant uropathogenic Escherichia coli (UPEC) strains and particularly of fluoroquinolone-resistance this is an alternative choice for the treatment of urinary tract infections. Methods: Bacterial samples (n = 250) were collected from out-patients from August 2012 to August 2014 Islamabad. Antibiotic susceptibility profiling and determination of mini-mum inhibitory concentrations (MICs) and minimum bactericidal concentrations were performed according to the guidelines of Clinical and Laboratory Standards Institute (CLSI, 2012). Genes, qnrA, qnrB and qnrS were identified by DNA amplification and sequencing. Results: The highest percentage of UPEC isolates were resistant to co-trimoxazole (82%) followed by cephalothin (80%), 2nd Gen, 3rd Gen and 4th Gen cephalosporins, respectively. Resistance against gentamicin, amikacin remained 29% and 4%. For other drugs including nitrofurantoin, tetracycline, carbapenem and beta-lactam inhibitors remained below 10%. Altogether, 59% of the isolates were resistant to at least three antibiotics including one fluoroquinolone. Overall, MICs for ciprofloxacin remained (MIC≥256 mg/mL) and for levofloxacin (MIC≥16 mg/mL and 32 mg/mL). No significant differences were observed regarding MIC values of extended spectrum b-lactamase (ESBL) and non-ESBL producers. For qnrS and qnrB positive isolates MICs remained above 32 mg/mL. Prevalence of UPEC was significantly higher among females and 40% of the isolates were ESBL producers. Conclusions: Higher percentages of ESBL producing UPEC were associated with uri-nary tract infections. Moreover, the majority of these isolates were multi-drug resistant and fluoroquinolone-resistant.

  3. Prevalence and impact of minority variant drug resistance mutations in primary HIV-1 infection.

    Directory of Open Access Journals (Sweden)

    Joanne D Stekler

    Full Text Available OBJECTIVE: To evaluate minority variant drug resistance mutations detected by the oligonucleotide ligation assay (OLA but not consensus sequencing among subjects with primary HIV-1 infection. DESIGN/METHODS: Observational, longitudinal cohort study. Consensus sequencing and OLA were performed on the first available specimens from 99 subjects enrolled after 1996. Survival analyses, adjusted for HIV-1 RNA levels at the start of antiretroviral (ARV therapy, evaluated the time to virologic suppression (HIV-1 RNA<50 copies/mL among subjects with minority variants conferring intermediate or high-level resistance. RESULTS: Consensus sequencing and OLA detected resistance mutations in 5% and 27% of subjects, respectively, in specimens obtained a median of 30 days after infection. Median time to virologic suppression was 110 (IQR 62-147 days for 63 treated subjects without detectable mutations, 84 (IQR 56-109 days for ten subjects with minority variant mutations treated with ≥3 active ARVs, and 104 (IQR 60-162 days for nine subjects with minority variant mutations treated with <3 active ARVs (p = .9. Compared to subjects without mutations, time to virologic suppression was similar for subjects with minority variant mutations treated with ≥3 active ARVs (aHR 1.2, 95% CI 0.6-2.4, p = .6 and subjects with minority variant mutations treated with <3 active ARVs (aHR 1.0, 95% CI 0.4-2.4, p = .9. Two subjects with drug resistance and two subjects without detectable resistance experienced virologic failure. CONCLUSIONS: Consensus sequencing significantly underestimated the prevalence of drug resistance mutations in ARV-naïve subjects with primary HIV-1 infection. Minority variants were not associated with impaired ARV response, possibly due to the small sample size. It is also possible that, with highly-potent ARVs, minority variant mutations may be relevant only at certain critical codons.

  4. High prevalence of childhood multi-drug resistant tuberculosis in Johannesburg, South Africa: a cross sectional study

    Directory of Open Access Journals (Sweden)

    Beylis Natalie C

    2011-01-01

    Full Text Available Abstract Background There are limited data on the prevalence of multi-drug resistant tuberculosis (MDR-TB, estimated at 0.6-6.7%, in African children with tuberculosis. We undertook a retrospective analysis of the prevalence of MDR-TB in children with Mycobacterium tuberculosis (MTB at two hospitals in Johannesburg, South Africa. Methods Culture-confirmed cases of MTB in children under 14 years, attending two academic hospitals in Johannesburg, South Africa during 2008 were identified and hospital records of children diagnosed with drug-resistant TB were reviewed, including clinical and radiological outcomes at 6 and 12 months post-diagnosis. Culture of Mycobacterium tuberculosis complex (MTB was performed using the automated liquid broth MGIT™ 960 method. Drug susceptibility testing (DST was performed using the MGIT™ 960 method for both first and second-line anti-TB drugs. Results 1317 children were treated for tuberculosis in 2008 between the two hospitals where the study was conducted. Drug susceptibility testing was undertaken in 148 (72.5% of the 204 children who had culture-confirmed tuberculosis. The prevalence of isoniazid-resistance was 14.2% (n = 21 (95%CI, 9.0-20.9% and the prevalence of MDR-TB 8.8% (n = 13 (95%CI, 4.8-14.6%. The prevalence of HIV co-infection was 52.1% in children with drug susceptible-TB and 53.9% in children with MDR-TB. Ten (76.9% of the 13 children with MDR-TB received appropriate treatment and four (30.8% died at a median of 2.8 months (range 0.1-4.0 months after the date of tuberculosis investigation. Conclusions There is a high prevalence of drug-resistant tuberculosis in children in Johannesburg in a setting with a high prevalence of HIV co-infection, although no association between HIV infection and MDR-TB was found in this study. Routine HIV and drug-susceptibility testing is warranted to optimize the management of childhood tuberculosis in settings such as ours.

  5. Short communication: high prevalence of drug-resistant human immunodeficiency virus type 1 in treatment-naive patients in Greenland

    DEFF Research Database (Denmark)

    Madsen, T.V.; Lohse, N.; Jensen, E.S.;

    2008-01-01

    A molecular epidemiologic study of HIV-1 in Greenland showed distinct transmission clusters correlated with demographic and behavioral data. Resistance mutations were found in a majority of the pol sequences. The objective of the present study was to estimate prevalence of drug resistance in...... Greenland and identify transmission chains by comparing resistance data with phylogeny and treatment history. Of 60 untreated patients, 15 (25%) had primary resistance mutations. The most prevalent mutations were T69D/N (15%), K70R (15%), and M184V (10%). Four possible transmission chains were identified...... based on phylogeny and mutation profiles. The clusters consisted of treated and untreated patients and showed the same mutation profiles in both resistance and nonresistance positions. Prevalence of transmitted drug resistance in Greenland (25%) is higher than in Denmark where only 3% transmission was...

  6. Potential of Rapid Diagnosis for Controlling Drug-Susceptible and Drug-Resistant Tuberculosis in Communities Where Mycobacterium tuberculosis Infections Are Highly Prevalent

    Science.gov (United States)

    Uys, Pieter W.; Warren, Robin; van Helden, Paul D.; Murray, Megan; Victor, Thomas C.

    2009-01-01

    The long-term persistence of Mycobacterium tuberculosis in communities with high tuberculosis prevalence is a serious problem aggravated by the presence of drug-resistant tuberculosis strains. Drug resistance in an individual patient is often discovered only after a long delay, particularly if the diagnosis is based on current culture-based drug sensitivity testing methods. During such delays, the patient may transmit tuberculosis to his or her contacts. Rapid diagnosis of drug resistance would be expected to reduce this transmission and hence to decrease the prevalence of drug-resistant strains. To investigate this quantitatively, a mathematical model was constructed, assuming a homogeneous population structure typical of communities in South Africa where tuberculosis incidence is high. Computer simulations performed with this model showed that current control strategies will not halt the spread of multidrug-resistant tuberculosis in such communities. The simulations showed that the rapid diagnosis of drug resistance can be expected to reduce the incidence of drug-resistant cases provided the additional measure of screening within the community is implemented. PMID:19297604

  7. Potential of rapid diagnosis for controlling drug-susceptible and drug-resistant tuberculosis in communities where Mycobacterium tuberculosis infections are highly prevalent.

    Science.gov (United States)

    Uys, Pieter W; Warren, Robin; van Helden, Paul D; Murray, Megan; Victor, Thomas C

    2009-05-01

    The long-term persistence of Mycobacterium tuberculosis in communities with high tuberculosis prevalence is a serious problem aggravated by the presence of drug-resistant tuberculosis strains. Drug resistance in an individual patient is often discovered only after a long delay, particularly if the diagnosis is based on current culture-based drug sensitivity testing methods. During such delays, the patient may transmit tuberculosis to his or her contacts. Rapid diagnosis of drug resistance would be expected to reduce this transmission and hence to decrease the prevalence of drug-resistant strains. To investigate this quantitatively, a mathematical model was constructed, assuming a homogeneous population structure typical of communities in South Africa where tuberculosis incidence is high. Computer simulations performed with this model showed that current control strategies will not halt the spread of multidrug-resistant tuberculosis in such communities. The simulations showed that the rapid diagnosis of drug resistance can be expected to reduce the incidence of drug-resistant cases provided the additional measure of screening within the community is implemented. PMID:19297604

  8. Prevalência de interações medicamentosas em unidades de terapia intensiva no Brasil Prevalence of drug interactions in intensive care units in Brazil

    Directory of Open Access Journals (Sweden)

    Rhanna Emanuela Fontenele Lima de Carvalho

    2013-01-01

    Full Text Available OBJETIVO: Determinar a prevalência de interações medicamentosas em unidades de terapia intensiva e analisar a significância clínica das interações identificadas. MÉTODOS: Estudo multicêntrico, transversal e retrospectivo desenvolvido com 1124 pacientes em sete unidades de terapia intensiva (UTI de hospitais de ensino no Brasil. As informações sobre os medicamentos administrados com 24 horas e 120 horas de internação foram obtidas nas prescrições. RESULTADOS: Em 24 horas 70,6% dos pacientes apresentaram pelo menos uma interação medicamentosa. O número de interações medicamentosas detectadas em 24 horas foi 2299 e em 120 horas foi 2619. Midazolam, fentanil, fenitoína e omeprazol foram os fármacos com maior frequência de interações medicamentosas. CONCLUSÃO: Nesta amostra, interações medicamentosas moderadas e graves foram mais prevalentes. Diante desses resultados, todas as ações dos profissionais de saúde que prestam assistência ao paciente devem ser integradas visando identificar e prevenir possíveis eventos a medicamentos.OBJECTIVE: To determine the prevalence of drug interactions in intensive care units and to analyze the clinical significance of interactions identified. METHODS: A multicenter, retrospective and cross sectional study conducted with 1124 patients in the seven intensive care units of teaching hospitals in Brazil. Information on drugs administered at 24 hours and 120 hours of hospitalization was obtained from the prescriptions. RESULTS: Within 24 hours, 70.6% of patients had at least one drug interaction; the number at 24h was 2299, at 120 h it was 2619. Midazolam, fentanyl, phenytoin and omeprazole were the drugs with higher frequency of drug interactions. CONCLUSION: In this sample, moderate and severe drug interactions were more prevalent. In light of these findings, all actions of health professionals who provide care to these patients must be integrated in order to identify and prevent

  9. Prevalência do uso de drogas e desempenho escolar entre adolescentes Drug use prevalence and school performance among teenagers

    OpenAIRE

    Beatriz Franck Tavares; Jorge Umberto Béria; Maurício Silva de Lima

    2001-01-01

    OBJETIVO: Avaliar a prevalência do uso de drogas entre adolescentes de escolas com segundo grau. MÉTODOS: Com base em um delineamento transversal, foi realizado estudo em 1998 , em Pelotas, RS. Um questionário anônimo, auto-aplicado em sala de aula, foi respondido por uma amostra proporcional de estudantes com idade entre 10 e 19 anos, matriculados no primeiro grau (a partir da 5ª série) e no segundo grau, em todas as escolas públicas e particulares na zona urbana do município que tinham segu...

  10. The effect of scheduling and withdrawal of carisoprodol on prevalence of intoxications with the drug.

    Science.gov (United States)

    Høiseth, Gudrun; Karinen, Ritva; Sørlid, Hanne Kristin; Bramness, Jørgen G

    2009-11-01

    The centrally acting muscle relaxant carisoprodol has previously been shown to cause psychomotor impairment and to have a narrow therapeutic range. In Norway, carisoprodol was therefore reclassified to the highest scheduling level from 1 August 2007 and withdrawn from the market on 1 May 2008. The aim of this study was to examine to what extent this action resulted in reduced numbers of driving under the influence (DUI) cases and forensic autopsies concerning carisoprodol, as well as reduced numbers of contacts to the National Poisons Information Centre (NPIC) in Norway regarding carisoprodol. From 2004 to 2008, carisoprodol (and/or its metabolite meprobamate) was detected in a total of 1261 DUI cases, decreasing from 312 in 2004 to 47 in 2008. During the same period, carisoprodol was detected in 194 forensic autopsies, also here decreasing, from 53 cases in 2004 to 11 cases in 2008. The NPIC received 1180 contacts primarily concerning carisoprodol over this period, decreasing from 267 contacts in 2004 to 87 contacts in 2008. During the same period, the sales figures for carisoprodol decreased dramatically, and we observed a relation between the numbers of DUI cases, forensic autopsies and contacts to the NPIC concerning carisoprodol and the sales figures for the drug. This study showed that the rescheduling and withdrawal of carisoprodol from the Norwegian market had a positive effect on the prevalence of carisoprodol in impaired driving, deaths and contacts regarding intoxications. This, together with previous publications, indicates that the population reflected in our data uses regularly prescribed carisoprodol and, to a lesser degree, drug from an illegal street market. PMID:19663822

  11. Comparing ELISA test-positive prevalence, risk factors and management recommendations for Johne's disease prevention between organic and conventional dairy farms in Ontario, Canada.

    Science.gov (United States)

    Pieper, Laura; Sorge, Ulrike S; DeVries, Trevor; Godkin, Ann; Lissemore, Kerry; Kelton, David

    2015-11-01

    Johne's disease (JD) is a chronic, infectious disease in cattle. Between 2010 and 2013, a voluntary JD control program was successfully launched in Ontario, Canada, including a Risk Assessment and Management Plan (RAMP) and JD ELISA testing of the entire milking herd. Over the last decade, the organic dairy sector has been growing. However, organic farming regulations and philosophies may influence the risk for JD transmission on Ontario organic dairy farms. The aim of this cross-sectional study was to investigate differences in JD ELISA test positive prevalence, risk factors for JD and recommendations for JD prevention between organic and conventional dairy herds in Ontario. RAMP results (i.e. RAMP scores and recommendations) and ELISA results were available for 2103 dairy herds, including 42 organic herds. If available, additional data on milk production, milk quality, and herd characteristics were gathered. Organic and conventional herds had a similar herd-level JD ELISA test-positive prevalence (26.2% and 27.2%, respectively). Organic herds (4.2%) had a higher within-herd JD ELISA test-positive prevalence compared to conventional herds (2.3%) if they had at least one JD test-positive animal on the farm. Organic farms had lower risk scores for biosecurity (9 points lower), and higher scores in the calving (7 points higher) and the calf-rearing management areas (4 points higher). After accounting for RAMP score, organic farms received fewer recommendations for the calving management area (Odds Ratio=0.41) and more recommendations in the adult cow management area (Odds Ratio=2.70). A zero-inflated negative binomial model was built with purchase of animals and the herd size included in the logistic portion of the model. Herd type (organic or conventional), colostrum and milk feeding practices, average bulk tank somatic cell count, and presence of non-Holstein breeds were included in the negative binomial portion of the model. Organic farms had a higher number of

  12. Injecting drugs in tight spaces: HIV, cocaine and collinearity in the Downtown Eastside, Vancouver, Canada.

    Science.gov (United States)

    Ciccarone, Daniel; Bourgois, Philippe

    2016-07-01

    This commentary revisits the political turmoil and scientific controversy over epidemiological study findings linking high HIV seroincidence to syringe exchange attendance in Vancouver in the mid-1990s. The association was mobilized polemically by US politicians and hard-line drug warriors to attack needle exchange policies and funding. In turn, program restrictions limiting access to syringes at the Vancouver exchange may have interfaced with a complex conjunction of historical, geographic, political economic and cultural forces and physiological vulnerabilities to create an extraordinary HIV risk environment: (1) ghettoization of services for indigent populations in a rapidly gentrifying, post-industrial city; (2) rural-urban migration of vulnerable populations subject to historical colonization and current patterns of racism; and (3) the flooding of North America with inexpensive powder cocaine and heroin, and the popularity of crack. In fact, we will never know with certainty the precise cause for the extreme seroincidence rates in Vancouver in the early to mid-1990s. The tendency for modern social epidemiology to decontextualize research subjects and assign excessive importance to discrete, "magic bullet" variables resulted in a counterproductive scientific and political debate in the late 1990s that has obfuscated potentially useful practical lessons for organizing the logistics of harm reduction services - especially syringe exchange - to better serve the needs of vulnerable populations and to mitigate the effects of political-economically imposed HIV risk environments. We would benefit from humbly acknowledging the limits of public health science and learn to recognize the unintended consequences of well-intentioned interventions rather than sweep embarrassing histories under the rug. PMID:27117187

  13. Prevalence of lifetime tobacco, alcohol and drug use among 10th grade students in Istanbul

    Directory of Open Access Journals (Sweden)

    cuneyt evren

    2014-01-01

    Full Text Available Objective: The aim of this study was to determine the prevalence of lifetime tobacco, alcohol and drug use among 10th grade students in Istanbul, Turkey. Method: A cross-sectional online self-report survey was conducted in 45 schools from 15 districts in Istanbul. The questionnaire included sections about demographic data, substance use in family or in environment, school life, social contacts and use of substances including tobacco, hookah, alcohol, marijuana, volatiles, heroin, cocaine, non-prescribed legal tranquillizers (benzodiazepines, alprazolam etc. and illegal tranquillizers (şunitrazepam. The analyses were conducted based on 4957 subjects. Results: A trial at least once in life is observed mostly in hookah use (45.4, followed by alcohol (34.2, cigarettes (24.4, volatile substances (4.9, benzodiazepines (3.8, marijuana (2.9, cocaine (0.6 and heroin (0.4, respectively. The risk of heroin, ecstasy or marijuana use was significantly higher among male students. Our data also show that using tobacco or alcohol increases the risk of use of all other substances. Conclusion: We believe that determining current substance use data in Istanbul, which has a heterogeneous structure and a population of 15 million, is very important. Nevertheless, it is obvious that a study covering different geographical regions of Turkey is also necessary.

  14. Baseline HCV Antibody Prevalence and Risk Factors among Drug Users in China's National Methadone Maintenance Treatment Program.

    Directory of Open Access Journals (Sweden)

    Changhe Wang

    Full Text Available Hepatitis C virus (HCV is the most common viral infection among injecting drug users worldwide. We aimed to assess HCV antibody prevalence and associated risk factors among clients in the Chinese national methadone maintenance treatment (MMT program.Data from 296,209 clients who enrolled in the national MMT program between March 2004 and December 2012 were analyzed to assess HCV antibody prevalence, associated risk factors, and geographical distribution.Anti-HCV screening was positive for 54.6% of clients upon MMT entry between 2004 and 2012. HCV antibody prevalence at entry declined from 66.8% in 2005 to 45.9% in 2012. The most significant predictors of HCV seropositivity were injecting drug use (adjusted odds ratio [AOR]: 8.34, 95% confidence interval [CI]: 8.17-8.52, p<0.0001 and a history of drug use ≥9 years (AOR: 2.01, 95% CI: 1.96-2.06, p<0.0001. Being female, of Uyghur or Zhuang ethnicity, and unmarried were identified as demographic risk factors (all p-values<0.0001. Of the 28 provincial-level divisions included in the study, we found that 5 divisions had HCV antibody prevalence above 70% and 20 divisions above 50%. The HCV screening rate within 6 months after MMT entry greatly increased from 30.4% in 2004 to 93.1% in 2012.The current HCV antibody prevalence remains alarmingly high among MMT clients throughout most provincial-level divisions in China, particularly among injecting drug users and females. A comprehensive prevention strategy is needed to control the HCV epidemic among MMT clients in China.

  15. Prevalence and determinants of resistance to use drugs among adolescents who had an opportunity to use drugs *

    OpenAIRE

    Lopez-Quintero, Catalina; Neumark, Yehuda

    2015-01-01

    Background As drugs remain ubiquitous and their use increasingly viewed as socially normative, vulnerable population groups such as adolescents face continued and growing risk. A better understanding of the factors that discourage individuals from initiating drug use, particularly in enabling scenarios, is therefore needed. This study aims to identify individual, interpersonal and school-contextual factors associated with resistance to using drugs in the presence of a drug use opportunity amo...

  16. Prevalence and occurrence rate of Mycobacterium tuberculosis Haarlem family multi-drug resistant in the worldwide population: A systematic review and meta-analysis

    OpenAIRE

    Rashid Ramazanzadeh; Daem Roshani; Pegah Shakib; Samaneh Rouhi

    2015-01-01

    Background: Transmission of Mycobacterium tuberculosis (M. tuberculosis) can occur in different ways. Furthermore, drug resistant in M. tuberculosis family is a major problem that creates obstacles in treatment and control of tuberculosis (TB) in the world. One of the most prevalent families of M. tuberculosis is Haarlem, and it is associated with drug resistant. Our objectives of this study were to determine the prevalence and occurrence rate of M. tuberculosis Haarlem family multi-drug resi...

  17. Prevalence of HIV Infection and Risk Behaviors Among Younger and Older Injecting Drug Users in the United States, 2009

    Science.gov (United States)

    Pham, Huong; Spiller, Michael; Wejnert, Cyprian; Le, Binh; Neaigus, Alan; Paz-Bailey, Gabriela

    2016-01-01

    This study compared HIV sero-prevalence and risk behaviors between younger and older injecting drug users (IDUs). IDUs aged ≥18 years were interviewed for the 2009 National HIV Behavioral Surveillance System. Using GEE regression, we assessed characteristics of younger (18–29 years) and older (≥30 years) IDUs, and factors associated with past 12-month receptive syringe sharing and unprotected sex (vaginal/anal). Of 10,090 participants, 10 % were younger. HIV sero-prevalence was lower among younger than older IDUs (4 vs. 10 %, p = 0.001). Younger IDUs were more likely (p ≤ 0.002) to be non-black race/ethnicity, report higher household income, homelessness, being arrested and to engage in receptive syringe sharing and unprotected sex. In multivariable models, age remained associated (p HIV prevalence, their behaviors place them at increased risk of HIV infection and could lead to a rapid spread in this susceptible population. PMID:24242754

  18. Why the FUSS (Fentanyl Urine Screen Study)? A cross-sectional survey to characterize an emerging threat to people who use drugs in British Columbia, Canada

    OpenAIRE

    Amlani, Ashraf; McKee, Geoff; Khamis, Noren; Raghukumar, Geetha; Tsang, Erica; Jane A Buxton

    2015-01-01

    Background Fentanyl-detected illicit drug overdose deaths in British Columbia (BC) recently increased dramatically from 13 deaths in 2012 to 90 deaths in 2014, signaling an emerging public health concern. Illicit fentanyl is sold as pills or powders, often mixed with other substances like heroin or oxycodone; reports from coroners suggested that fentanyl was frequently taken unknowingly by people who use drugs. This study aimed to assess the prevalence and characteristics of fentanyl use amon...

  19. The impact of land use, season, age, and sex on the prevalence and intensity of Baylisascaris procyonis infections in raccoons (Procyon lotor) from Ontario, Canada.

    Science.gov (United States)

    Jardine, Claire M; Pearl, David L; Puskas, Kirstie; Campbell, Doug G; Shirose, Lenny; Peregrine, Andrew S

    2014-10-01

    We assessed the impact of land use, demographic factors, and season on the prevalence and intensity of Baylisascaris procyonis infections in raccoons (Procyon lotor) in Ontario, Canada. From March to October 2012, we recorded the number of B. procyonis in the intestinal tracts of raccoons submitted to the Canadian Cooperative Wildlife Health Centre for necropsy. Logistic regression models were used to examine associations between the presence of B. procyonis and age (adult, juvenile), sex, land use (suburban/urban, rural), and season (March-June and July-October); negative binomial regression models were used to examine associations between the number of worms and the same variables. We detected B. procyonis in 38% (95% confidence interval 30-47%) of raccoons examined (n=128). In univariable models, the presence of B. procyonis was significantly associated with age, land use, and season (Praccoons were significantly more likely to be infected with B. procyonis than suburban/urban female raccoons. However, later in the summer (July-October), the opposite was true. The median number of worms in the intestinal tracts of infected raccoons was 3 (range 1-116). Worm number was significantly associated with age and season in univariable models; in the multivariable model, juvenile raccoons had significantly more worms than adults, and the impact of season on the number of worms varied with land use and sex. A better understanding of the epidemiology of B. procyonis in raccoons is important for developing appropriate strategies to reduce the risk of human exposure to B. procyonis from the environment. PMID:25098302

  20. Prevalence of hypersensitivity to dental local anesthetic drugs in patients referred to Tehran Allergy clinic (2005-2007

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    Akhlaghi F.

    2009-03-01

    Full Text Available "nBackground and Aim: According to controversies in the prevalence of hypersensitivity to dental local anesthetic drugs and patients who claim hypersensitivity to these drugs, the aim of this study was to determine the prevalence of hypersensitivity to dental amide local anesthetic drugs in patients referred to Tehran Allergy Clinic in 2005-2007. "nMaterials and Methods: In this Study (Review of existing data, records of 130 patients who were referred to "Tehran allergy Clinic" (2005-2007 were studied. "nResults: The average age of patients was 29.5±18.8 years. 34% of cases showed positive skin reactions to at least one of the tested Lidocain concentrations and 10% of cases showed positive skin reactions to at least one of the tested Prilocain concentrations. There was a statistically significant difference in hypersensitivity to Lidocain 0.01 and 0.001 (p=0.017 and also between Lidocain 0.001 and 0.0001 (p<0.01. There was no statistically significant difference between other tested drug concentrations (p>0.05. "nConclusion: Many patients with history of hypersensitivity, show positive reaction to local dental anesthetic drugs. Prilocain hypersensitivity reactions are less than Lidocain. So application of Prilocain accompanies with less risk but its application should not be considered completely safe.

  1. Predictors of HIV infection and prevalence for syphilis infection among injection drug users in China: Community-based surveys along major drug trafficking routes

    Directory of Open Access Journals (Sweden)

    Li Chunmei

    2008-08-01

    Full Text Available Abstract Objective To assess the predictors and prevalence of HIV infection among injection drug users in highly endemic regions along major drug trafficking routes in three Chinese provinces. Methods We enrolled participants using community outreach and peer referrals. uestionnaire-based interviews provided demographic, drug use, and sexual behavior information. HIV was tested via ELISA and syphilis by RPR. Results Of the 689 participants, 51.8% were HIV-infected, with persons living in Guangxi having significantly lower prevalence (16.4% than those from Xinjiang and Yunnan (66.8% and 67.1%, respectively. Syphilis seropositivity was noted in 5.4%. Longer duration of IDU, greater awareness of HIV transmission routes, and living in Xinjiang or Yunnan were associated with HIV seropositivity on multivariable analysis. Independent risk factors differed between sites. In Guangxi, being male and having a longer duration of IDU were independent risk factors for HIV infection; in Xinjiang, older age and sharing needles and/or syringes were independent factors; in Yunnan, more frequent drug injection, greater awareness of HIV transmission routes, and higher income were independent predictors of HIV seropositivity. Conclusion Prevalence rates of HIV among IDUs in China are more than two out of three in some venues. Risk factors include longer duration of IDU and needle sharing. Also associated with HIV were factors that may indicate some success in education in higher risk persons, such as higher knowledge. A systemic community-level intervention with respect to evidenced-based, population-level interventions to stem the spread of HIV from IDU in China should include needle exchange, opiate agonist-based drug treatment, condom distribution along with promotion, and advocacy for community-based VCT with bridges to HIV preventive services and care.

  2. Alcohol and Drug Use Prevalence and Factors Associated With the Experience of Alcohol Use in Iranian Adolescents

    OpenAIRE

    Baheiraei, Azam; Hamzehgardeshi, Zeinab; MOHAMMADI, Mohammad Reza; Nedjat, Saharnaz; Mohammadi, Eesa

    2013-01-01

    Background Alcohol and other drugs use is a problem among adolescents leading to numerous physical, social, and educational damages. Objective For determining the prevalence of alcohol and other substance use as well as the factors associated with the experience of alcohol use in adolescents. Patients and Methods This is a population-based and cross-sectional study, which was conducted in August 2010 on adolescents aged 15–18 years in Tehran. Data were collected by a Youth Risk Behavior Surve...

  3. Prevalence of multi drug resistant Acinetobacter baumannii in the clinical samples from Tertiary Care Hospital in Islamabad, Pakistan

    OpenAIRE

    Begum, Shahzeera; Hasan, Fariha; Hussain, Shagufta; Ali Shah, Aamer

    2013-01-01

    Background & Objectives: Acinetobacter baumannii can cause a wide range of infections, including bacteremia, pneumonia, urinary tract infection, peritonitis, etc. This organism is becoming resistant to a large group of antibiotics, especially β-lactam antibiotics. The reason for multi-drug resistance may be the production of extended- spectrum β-lactamses (ESBLs), carbapenemases/metallo β-lactamases or AmpC β-lactamases. The aim of the present study was to determine the prevalence of multi-dr...

  4. Liquid Drugs and High Dead Space Syringes May Keep HIV and HCV Prevalence High – A Comparison of Hungary and Lithuania

    Science.gov (United States)

    Gyarmathy, V. Anna; Neaigus, Alan; Li, Nan; Ujhelyi, Eszter; Caplinskiene, Irma; Caplinskas, Saulius; Latkin, Carl A.

    2010-01-01

    Despitevery similar political, drug policy and HIV prevention backgrounds, HIV and HCV prevalence is considerably different in Hungary (low HIV and moderate HCV prevalence) and Lithuania (high HCV and moderate HIV prevalence). Wecompared the drug use profile of Hungarian (n = 215) and Lithuanian (n = 300) injecting drug users (IDUs). Overall, compared with IDUs in Hungary, IDUs in Lithuania often injected opiates purchased in liquid form (‘shirka’), used and shared 2-piece syringes (vs. 1-piece syringes) disproportionately more often, were less likely to acquire their syringes from legal sources and had significantly more experience with injected and less experience with non-injected drugs. It may not be liquid drugs per se that contribute to a higher prevalence of HCV and/or HIV, but it is probably factors associated with the injecting of liquid drugs, such as the wide-spread use and sharing of potentially contaminated 2-piece syringes acquired often from non-legal sources, and syringe-mediated drug sharing with 2-piece syringes. Scaling up substitution therapy, especially heroin replacement, combined with reducing the supply of liquid drugs may decrease the prevalence of high-risk injecting behaviours related to the injecting of liquid drugs and drug injecting-related infections among IDUs in Lithuania. PMID:20798543

  5. Comorbid drug use disorders and eating disorders: a review of prevalence studies

    OpenAIRE

    Nøkleby, Heid

    2012-01-01

    AIMS – This study reviews literature on comorbidity of drug use disorders (DUD) and eating disorders (ED). The article updates knowledge on the occurrence of comorbidity of these diagnoses. METHODS – The databases Embase, Medline and PsycInfo were searched for studies published between 1990 and May 2011, with combinations of the terms ’eating disorder’, ’substance-related disorder’, ’drug dependence’, ’drug abuse’, ’drug addiction’ and ’substance abuse’. This generated altogether ...

  6. Prevalence and Characteristics of Abuse Experiences and Depression Symptoms among Injection Drug-Using Female Sex Workers in Mexico

    Directory of Open Access Journals (Sweden)

    Monica D. Ulibarri

    2013-01-01

    Full Text Available This mixed methods study examined the prevalence and characteristics of physical and sexual abuse and depression symptoms among 624 injection drug-using female sex workers (FSW-IDUs in Tijuana and Ciudad Juarez, Mexico; a subset of 47 from Tijuana also underwent qualitative interviews. Linear regressions identified correlates of current depression symptoms. In the interviews, FSW-IDUs identified drug use as a method of coping with the trauma they experienced from abuse that occurred before and after age 18 and during the course of sex work. In a multivariate linear regression model, two factors—ever experiencing forced sex and forced sex in the context of sex work—were significantly associated with higher levels of depression symptoms. Our findings suggest the need for integrated mental health and drug abuse services for FSW-IDUs addressing history of trauma as well as for further research on violence revictimization in the context of sex work in Mexico.

  7. HIGH PREVALENCE OF INCOMPATIBILITY GROUP INCA/C AMONG MULTI-DRUG RESISTANT SALMONELLA ENTERICA SEROTYPE NEWPORT ISOLATED FROM DAIRY CATTLE

    Science.gov (United States)

    Multi-drug resistant (MDR) Salmonella enterica serotype Newport exhibiting increased morbidity and mortality among man and animals has emerged in North America and Canada. Risk factors for infection by MDR S. Newport have included exposure to dairy farms, consumption of undercooked ground beef or u...

  8. Prevalence of illicit drug use in patients without controlled substance abuse in interventional pain management.

    Science.gov (United States)

    Manchikanti, Laxmaiah; Pampati, Vidyasagar; Damron, Kim S; Beyer, Carla D; Barnhill, Renee C

    2003-04-01

    Drug abuse with illicit drugs and licit drugs has been increasing steadily over the past decade. A recent National Household Survey on Drug Abuse found statistically significant increases between 2000 and 2001 in the use of multiple drugs, including marijuana, cocaine, and non-medical use of pain relievers and tranquilizers. Prescription controlled substance abuse is a major issue in chronic pain management. Various means suggested to avoid or monitor abuse in patients in treatment include urine/serum drug screening whenever requested, along with other precautions including one prescribing physician and one designated pharmacy, etc. Based on the present evidence, physicians assume that patients adhering to controlled substance agreements and without obvious dependency behavior do not abuse either illicit or licit drugs. Thus, it is accepted that there is no necessity to perform routine urine/drug testing in this specific group of the patient population. One hundred patients undergoing interventional pain management and receiving controlled substances were randomly selected for evaluation of illicit drug abuse by urine drug testing. They were selected from a total of 250 patients who were identified as non-abusers of prescription drugs. Results showed that illicit drug abuse in patients without history of controlled substance abuse was seen in 16 patients. Thirteen of the 16 patients tested positive for marijuana and 3 patients tested positive for cocaine. Only one patient tested positive for a combined use of both marijuana and cocaine. This study showed that, in an interventional pain management setting, there is significant use of illicit drugs (16%) with 13% use of marijuana and 3% use of cocaine in patients who are considered as non-abusers of prescription controlled substances and those who are adherent to controlled substance agreements. However, if cocaine is considered as a hardcore drug in contrast to marijuana, abuse of hardcore illicit drugs is only 3

  9. Uso de drogas psicotrópicas por estudantes: prevalência e fatores sociais associados Use of psychotropics drugs among students: prevalence and associated social factors

    Directory of Open Access Journals (Sweden)

    Meire Soldera

    2004-04-01

    Full Text Available OBJETIVO: Determinar a prevalência do uso pesado de drogas por estudantes de primeiro e segundo graus em uma amostra de escolas públicas e particulares, e identificar fatores demográficos, psicológicos e socioculturais associados. MÉTODOS: Trata-se de um estudo transversal com uma técnica de amostragem do tipo intencional comparando-se escolas públicas de áreas periféricas e centrais e escolas particulares. Foi utilizado um questionário anônimo de autopreenchimento. A amostra foi constituída por 2.287 estudantes de primeiro e segundo graus da cidade de Campinas, SP, no ano de 1998. Considerou-se uso pesado, o uso de drogas em 20 dias ou mais nos 30 dias que antecederam a pesquisa. Para análise estatística, utilizou-se a análise de regressão logística politômica - modelo logito, visando identificar fatores que influenciem este modo de usar drogas. RESULTADOS: O uso pesado de drogas lícitas e ilícitas foi de: álcool (11,9%, tabaco (11,7%, maconha (4,4%, solventes (1,8%, cocaína (1,4%, medicamentos (1,1%, ecstasy (0,7%. O uso pesado foi maior entre os estudantes da escola pública central, do período noturno, que trabalhavam, pertencentes aos níveis socioeconômicos A e B, e cuja educação religiosa na infância foi pouco intensa. CONCLUSÕES: Maior disponibilidade de dinheiro e padrões específicos de socialização foram identificados como fatores associados ao uso pesado de drogas em estudantes.OBJECTIVE: To determine the prevalence of the heavy use of drugs among elementary and high school students in a sample of public and private schools, and to identify associated demographic, psychological, cultural and social factors. METHODS: This report describes a cross-sectional study using an intention-type sampling technique that compared public schools in central and peripheral areas and private schools. An anonymous self-administered questionnaire was applied. The sample consisted of 2,287 elementary and high school

  10. The Prevalence of Fentanyl in Drug-Related Deaths in Philadelphia 2004–2006

    OpenAIRE

    Wong, Stella C.; Mundy, Lisa; Drake, Rebecca; Curtis, John A.; Wingert, William E.

    2010-01-01

    Fentanyl is an increasingly common drug of abuse. The Philadelphia Medical Examiner's Office reported 252 drug-related deaths in Philadelphia that tested positive for fentanyl during the year 2006 in comparison to 22 and 19 in 2005 and 2004, respectively. We reviewed the data from 2004 to 2006 from the Philadelphia Medical Examiner's office. Key words such as fentanyl, drug, cocaine, ethanol, medic (medication), tox (intoxication), or poison were used as search words. In comparison to 2004 an...

  11. Effectiveness of two rounds of mass drug administration using DEC combined with albendazole on the prevalence of Brugia malayi

    OpenAIRE

    Santoso Santoso; Aprioza Yenni; Reni Oktarina; Tri Wurisastuti

    2015-01-01

    Background: Filariasis mass drug administration carried out for 5 consecutive years aims to reduce the prevalence rate of < 1%. Evaluation of treatment needs to be done, one of them with a finger blood survey. This study aims to assess the effectiveness of mass treatment and factors that influence. Methods:The study design was cross-sectional study. Blood sampling performed at night in four selected villages with a number of samples for blood tests as many as 1,209 people. Results:The numb...

  12. Drug-resistance mechanisms and prevalence of Enterobacter cloacae resistant to multi-antibiotics

    Institute of Scientific and Technical Information of China (English)

    张杰; 顾怡明; 俞云松; 周志慧; 杜小玲

    2004-01-01

    @@The main drug-resistance mechanism of gram-negative bacteria is producing β-lactamases. Two kinds of enzymes cause drug resistance by hydrolyzing oxyimino-cephalosporins and aztreonam: one is chromosomally encoded AmpC β-lactamases, the other is plasmid-mediated extended-spectrum β-lactamases (ESBLs). Enterobacter cloacae can produce both of them, so that these strains are seriously resistance to many antibiotics. In order to study the main drug-resistant mechanism in Enterobacter cloacae, PCR and nucleotide sequencing were performed on 58 multidrug resistant strains.

  13. Prevalence of drug-related problems in self-medication in Danish community pharmacies

    OpenAIRE

    Charlotte Rossing; Hanne Herborg; Nina Griese; Tina Bolvig; Bente Frøkjær

    2012-01-01

    Background: Drug-related problems are known to be a major problem associated with pharmacotherapy. A broad range of studies, mainly in the area of prescription-only medicines, supports this fact. Only a few studies have evaluated drug-related problems with over-the-counter medicine and the role of community pharmacies in this.Purpose: To quantify drug-related problems in self-medication (use of over-the-counter medicine) identified by community pharmacies in Denmark and to document the interv...

  14. Prevalence of adverse drug reactions at a private tertiary care hospital in south India

    Directory of Open Access Journals (Sweden)

    Shanmugam Sriram

    2011-01-01

    Conclusions: Measures to improve detection and reporting of adverse drug reactions by all health care professionals is recommended to be undertaken, to ensure, and improve patient′s safety. In this way, hospital/clinical pharmacists play the cornerstone role.

  15. Prevalence of hepatitis C virus infection and its related risk factors in drug abuser prisoners in Hamedan - Iran

    Institute of Scientific and Technical Information of China (English)

    Amir Houshang Mohammad Alizadeh; Seyed Moayed Alavian; Khalil Jafari; Nastaran Yazdi

    2005-01-01

    AIM: Recent studies in Iran has shown that prevalence of hepatitis C virus (HCV) infection among Iranian prisoners is high, in spite of low HCV seroprevalence in general population.METHODS: This study was carried out in the central prison of Hamedan - Iran, in year 2002. Inmates were interviewed using a standard questionnaire including demographic,imprisonment history and HCV-related risk behaviors items. Thereafter, the sera drawn from the participants were tested for anti-HIV and anti-HCV antibodies.RESULTS: A total number of 427 drug abuser inmates participated in our study. Three hundred and ninety-seven (93%) were men and 30 (7%) were women. Total number of Ⅳ drug abusers (IDA) and non-Ⅳ drug abusers (NIDA)was 149 (34.9%) and 278 (65.1%), respectively. The overall rate of antibody positivity among inmates was 0.9% for HIV and 30% for HCV. Of all IDAs, 31.5% and of NIDAs, 29.1% had serological evidence of HCV infection.CONCLUSION: The seroprevalence of HCV infection among drug abuser prisoners in comparison with the general population in Iran, is very high (30% vs in italics 0.2%).Our results indicate the importance of policies to prevent transmission of HCV infection during and following incarceration.

  16. Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal Kenya.

    Science.gov (United States)

    Okombo, John; Kamau, Alice W; Marsh, Kevin; Sutherland, Colin J; Ochola-Oyier, Lynette Isabella

    2014-12-01

    Molecular surveillance of drug resistance markers through time provides crucial information on genomic adaptations, especially in parasite populations exposed to changing drug pressures. To assess temporal trends of established genotypes associated with tolerance to clinically important antimalarials used in Kenya over the last two decades, we sequenced a region of the pfcrt locus encompassing codons 72-76 of the Plasmodium falciparum chloroquine resistance transporter, full-length pfmdr1 - encoding multi-drug resistance protein, P-glycoprotein homolog (Pgh1) and pfdhfr encoding dihydrofolate reductase, in 485 archived Plasmodium falciparum positive blood samples collected in coastal Kenya at four different time points between 1995 and 2013. Microsatellite loci were also analyzed to compare the genetic backgrounds of parasite populations circulating before and after the withdrawal of chloroquine and sulfadoxine/pyrimethamine. Our results reveal a significant increase in the prevalence of the pfcrt K76 wild-type allele between 1995 and 2013 from 38% to 81.7% (p drug in contrast to a selective sweep around the triple mutant pfdhfr allele, leading to a mono-allelic population at this locus. These findings highlight the importance of continual surveillance and characterization of parasite genotypes as indicators of the therapeutic efficacy of antimalarials, particularly in the context of changes in malaria treatment policy. PMID:25516825

  17. Declining prevalence of HIV-infected individuals at risk of transmitting drug-resistant HIV in Denmark during 1997-2004

    DEFF Research Database (Denmark)

    Lohse, Nicolai; Obel, Niels; Kronborg, Gitte; Jørgensen, Louise Bruun; Pedersen, Court; Larsen, Carsten Schade; Kvinesdal, Birgit; Sørensen, Henrik Toft; Gerstoft, Jan

    2006-01-01

    resistance and examined temporal trends in the prevalence of patients at risk of transmitting drug-resistant HIV. METHODS: The study population included all 4,025 patients from The Danish HIV Cohort Study seen during the period 1995-2004. Virological failure to a given drug class was defined as a viral load......-resistant virus in subsequent observation time. Patients with a current VL > 1,000 copies/ml were considered at risk of transmitting HIV. RESULTS: We found a decrease from 1997 to 2004 in the prevalence of potential transmitters of drug-resistant HIV. The number of these patients with previous NRTI failure...

  18. Declining prevalence of HIV-infected individuals at risk of transmitting drug-resistant HIV in Denmark during 1997-2004

    DEFF Research Database (Denmark)

    Lohse, Nicolai; Obel, Niels; Kronborg, Gitte; Bruun Jørgensen, Louise; Pedersen, Court; Schade Larsen, Carsten; Kvinesdal, Birgit; Toft Sørensen, Henrik; Gerstoft, Jan

    2006-01-01

    resistance and examined temporal trends in the prevalence of patients at risk of transmitting drug-resistant HIV. METHODS: The study population included all 4,025 patients from The Danish HIV Cohort Study seen during the period 1995-2004. Virological failure to a given drug class was defined as a viral load......-resistant virus in subsequent observation time. Patients with a current VL > 1,000 copies/ml were considered at risk oftransmitting HIV. RESULTS: We found a decrease from 1997 to 2004 in the prevalence of potential transmitters of drug-resistant HIV. The number of these patients with previous NRTI failure...

  19. Trends in overweight prevalence among 11-, 13- and 15-year-olds in 25 countries in Europe, Canada and USA from 2002 to 2010

    DEFF Research Database (Denmark)

    Ahluwalia, Namanjeet; Dalmasso, Paola; Rasmussen, Mette;

    2015-01-01

    BACKGROUND: The purpose of this study was to assess recent changes in the prevalence of overweight (including obesity) among 11-, 13- and 15-year-olds in 33 countries from 2002 to 2010. METHODS: Data from 25 countries from three consecutive survey cycles (2002, 2006 and 2010) that had at least 80...... prevalence did not change during 2002-2010. However, increasing overweight prevalence was noted in many Eastern European countries over this time period. Overweight prevalence remained high in several countries in Europe and North America. These patterns call for continued research in youth overweight and...

  20. Prevalence of drug resistance mutations and HIV type 1 subtypes in an HIV type 1-infected cohort in rural Tanzania.

    Science.gov (United States)

    Masimba, Pax; Kituma, Elimsaada; Klimkait, Thomas; Horvath, Edit; Stoeckle, Marcel; Hatz, Christoph; Mossdorf, Erick; Mwaigomole, Emmanuel; Khamis, Salim; Jullu, Boniphace; Abdulla, Salim; Tanner, Marcel; Felger, Ingrid

    2013-09-01

    The development of resistance mutations in drug-targeted HIV-1 genes compromises the success of antiretroviral therapy (ART) programs. Genotyping of these mutations enables adjusted therapeutic decisions both at the individual and population level. We investigated over time the prevalence of HIV-1 primary drug resistance mutations in treatment-naive patients and described the HIV-1 subtype distribution in a cohort in rural Tanzania at the beginning of the ART rollout in 2005-2007 and later in 2009. Viral RNA was analyzed in 387 baseline plasma samples from treatment-naive patients over a period of 5 years. The reverse transcriptase (RT) and protease genes were reversely transcribed, polymerase chain reaction (PCR) amplified, and directly sequenced to identify HIV-1 subtypes and single nucleotide polymorphisms associated with drug resistance (DR-SNPs). The prevalence of major DR-SNPs in 2005-2007 in the RT gene was determined: K103N (5.0%), Y181C (2.5%), M184V (2.5%), and G190A (1.7%), and M41L, K65KR, K70KR, and L74LV (0.8%). In samples from 2009 only K103N (3.3%), M184V, and T215FY (0.8%) were detected. Initial frequencies of subtypes C, A, D, and recombinants were 43%, 32%, 18%, and 7%, respectively. Later similar frequencies were found except for the recombinants, which were found twice as often (15%), highlighting the subtype diversity and a relatively stable subtype frequency in the area. DR-SNPs were found at initiation of the cohort despite very low previous ART use in the area. Statistically, frequencies of major mutations did not change significantly over the studied 5-year interval. These mutations could reflect primary resistances and may indicate a possible risk for treatment failure. PMID:23806135

  1. Prevalence and sunlight photolysis of controlled and chemotherapeutic drugs in aqueous environments

    International Nuclear Information System (INIS)

    This study addresses the occurrences and natural fates of chemotherapeutics and controlled drugs when found together in hospital effluents and surface waters. The results revealed the presence of 11 out of 16 drugs in hospital effluents, and the maximum detected concentrations were at the μg L−1 level in the hospital effluents and the ng L−1 level in surface waters. The highest concentrations corresponded to meperidine, morphine, 5-fluorouracil and cyclophosphamide. The sunlight photolysis of the target compounds was investigated, and the results indicated that morphine and codeine can be significantly attenuated, with half-lives of 0.27 and 2.5 h, respectively, in natural waters. Photolysis can lower the detected environmental concentrations, also lowering the estimated environmental risks of the target drugs to human health. Nevertheless, 5-fluorouracil and codeine were found to have a high risk quotient (RQ), demonstrating the high risks of directly releasing hospital wastewater into the environment. - Highlights: • High occurrence of chemotherapeutics and controlled substances in aqueous systems. • Photolysis lowers the detected concentrations of morphine and codeine. • 5-fluorouracil and codeine in hospital effluents have high risk quotients. - Chemotherapeutics and controlled drugs occur at significant levels in hospital effluents and surface waters. Natural sunlight photolysis reduces their environmental occurrence

  2. Prevalence of use of performance enhancing drugs by fitness centre members

    NARCIS (Netherlands)

    Stubbe, J.H.; Chorus, A.M.J.; Frank, L.E.; Hon, O. de; Heijden, P.G.M. van der

    2014-01-01

    Studies on the use of performance enhancing drugs (PED) in fitness centres rely predominately on conventional survey methods using direct questioning. However, research indicates that direct questioning of sensitive information is characterized by under-reporting. The aim of the present study was to

  3. The Challenge of Counterfeit Drugs: A Comprehensive Review on Prevalence, Detection and Preventive Measures.

    Science.gov (United States)

    Kumar, Bharat; Baldi, Ashish

    2016-01-01

    Counterfeit drugs are a worldwide concern. This organized crime has deterrent effect on public health and on pharmaceutical business across the globe. Lack of comprehensive standardized definition of counterfeit drugs with global acceptance, higher benefits of cost ratio and intercomplexity of market and globalized network are the major reasons behind this. Unawareness among the stakeholders lack of intellectual property protection and social-economic factor also resulted in flourished market of fake drugs. Despite of several attempts made by global regulatory agencies, inefficient regulations, lax enforcement of existing legislation and lack of commitment by involved authorities still remain major loopholes, aggravating the serious problem of counterfeiting. Although use of techniques based on interference pattern, encryption, spectroscopy and chromatographic principles by pharmaceutical industries to authenticate genuine products has curtailed the problem to a limited extent. In order to efficiently control the organized crime of medicine counterfeiting, collective efforts of 'National Counterfeit Control Agencies', pharmaceutical industries, law regulatory agencies and public are essential. Strict legal enforcement, applications of comprehensive database, interlinked network and technological advancement are need of the hour. The purpose of this article is to overview all aspects of drug counterfeiting including current status and magnitude, effectiveness and limitation of existing technologies available to counter with particular attention to suggest possible roadmap to overcome the problem through uni-directional and focus global co-operation. PMID:26463250

  4. Prevalence of drug-related problems in self-medication in Danish community pharmacies

    Directory of Open Access Journals (Sweden)

    Charlotte Rossing

    2012-01-01

    Full Text Available Background: Drug-related problems are known to be a major problem associated with pharmacotherapy. A broad range of studies, mainly in the area of prescription-only medicines, supports this fact. Only a few studies have evaluated drug-related problems with over-the-counter medicine and the role of community pharmacies in this.Purpose: To quantify drug-related problems in self-medication (use of over-the-counter medicine identified by community pharmacies in Denmark and to document the interventions by pharmacy staff in relation to the identified drug-related problems.Method: A descriptive study mapping drug-related problems in self-medication registered at the counter at a selected number of Danish community pharmacies.Results: Data for 3,868 consecutive customers with requests for over-the-counter (OTC medicines were registered at 39 community pharmacies. The pharmacies registered a total number of 4,324 OTC medicines requests, illustrating that a customer requested 1.1 OTC medicines on average. Drug-related problems (DRPs were identified for 813 customers, equivalent to DRPs for 21.0 % of all customers, presenting symptoms or requesting OTC medicines, and for 20 % of all over-the-counter medicines requests. 1,239 DRPs were registered, corresponding to an average of 1.5 DRPs per customer requesting OTC medicines.Community pharmacies estimated that they solved or partly solved 76.2 % of the detected DRPs; 73 % were solved without involving a general practitioner.Conclusions: DRPs were identified for 21.0 % of the pharmacy customers presenting a symptom or asking for an OTC medicine. The community pharmacy counselled the customers with DRPs more thoroughly than other customers by giving 2.4 pieces of professional advice, compared to an average of 2.1 to customers in general. It is not possible to determine the magnitude of the safety risk involved. Based on the most frequent categories of DRPs, there were risks of insufficient effect, unintended

  5. Prevalence of molecular markers of Plasmodium falciparum drug resistance in Dakar, Senegal.

    OpenAIRE

    Wurtz Nathalie; Fall Bécaye; Pascual Aurélie; Diawara Silmane; Sow Kowry; Baret Eric; Diatta Bakary; Fall Khadidiatou B; Mbaye Pape S; Fall Fatou; Diémé Yaya; Rogier Christophe; Bercion Raymond; Briolant Sébastien; Wade Boubacar

    2012-01-01

    Abstract Background As a result of the widespread resistance to chloroquine and sulphadoxine-pyrimethamine, artemisinin-based combination therapy (ACT) (including artemether-lumefantrine and artesunate-amodiaquine) has been recommended as a first-line anti-malarial regimen in Senegal since 2006. Intermittent preventive treatments with anti-malarial drugs based on sulphadoxine-pyrimethamine are also given to children or pregnant women once per month during the transmission season. Since 2006, ...

  6. The prevalence of drug use among university students in St. Petersburg, Russia

    Directory of Open Access Journals (Sweden)

    Tsvetkova L. A.

    2013-01-01

    Full Text Available Over the last decade, the problem of young people's health has been among the most important and complicated ones for Russian society; these problems affect not only young children but also students in higher education institutions. The low level of physical and psychological health of young people has become an alarming characteristic of the demographic situation in modern Russia.This study was carried out at the State University of St. Petersburg, which is one of the largest higher education institutions in Russia. The university consists of many academic departments, and thus it is possible to study the health-related behavior of students with different professional backgrounds.The results show that drug use among students in Russia still remains relatively rare and episodic; in most cases, students use "light" drugs and thus have both slow rates of developing an addiction and an alternative but successful socialization in modern youth subculture. Such drugs are also not generally associated with significant health risks.

  7. Change in the Prevalence of HIV-1 and the Rate of Transmitted Drug-Resistant HIV-1 in Haiphong, Northern Vietnam.

    Science.gov (United States)

    Pham, Hung Viet; Ishizaki, Azumi; Nguyen, Cuong Hung; Saina, Matilda Chelimo; Hoang, Huyen Thi Thanh; Tran, Vuong Thi; Bi, Xiuqiong; Pham, Thuc Van; Ichimura, Hiroshi

    2015-07-01

    We previously reported a significant decrease in HIV-1 prevalence, with no increase in drug-resistant HIV-1 among injecting drug users (IDU), female sex workers (FSW), and blood donors (BD), in Haiphong, Vietnam, from 2007 to 2009. In 2012, 388 IDU, 51 FSW, and 200 BD were recruited for further analysis. None had a history of antiretroviral treatment. From 2007 to 2012, HIV-1 prevalence was reduced from 35.9% to 18.6% (pNonnucleoside RT inhibitor-resistant mutations, Y181C/I, were detected in three subjects; one had the nucleoside RT inhibitor-resistant mutations L74V and M184V and one had E138K. The prevalence of transmitted drug-resistant HIV-1 in Haiphong increased slightly from 1.8% in 2007 to 6.6% in 2012 (p=0.06). PMID:25970090

  8. The prevalence of isolated hepatitis B core antibody and its related risk factors among male injected drug users in Isfahan prisons

    OpenAIRE

    Kiana Shirani; Zary Nokhodian; Nazila Kassaian; Peyman Adibi; Alireza Emami Naeini; Behrooz Ataei

    2015-01-01

    Background: The prevalence of isolated hepatitis B core antibody (anti-HBc) varies between 1% and 30% in different populations. Isolated anti-HBc-positive patients who suffer from occult hepatitis B virus (HBV) infection have the potential to transmit HBV infection. So isolated anti-HBc screening is a valuable tool to prevent HBV transmission. Considering the importance of isolated anti-HBc screening and high prevalence of HBV among injected drug users (IDU) prisoners, we designed this study ...

  9. Evaluation of the Prevalence of Hepatitis B, Hepatitis C, and HIV in Inmates with Drug-Related Convictions in Birjand, Iran in 2008

    OpenAIRE

    Gholamreza Sharifzadeh; Zohreh Azarkar

    2010-01-01

    Background and Aims: Hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) are common infections among prisoners. Addicted prisoners are at a higher risk than the normal population for contracting these diseases. Many studies have reported higher prevalence rates of HBV, HCV, and HIV in prisoners. Because of this problem, this study was conducted to evaluate the serologic prevalence of these three diseases in prisoners convicted of drug-related crimes.Method...

  10. Prevalence and Correlates of the Use of Prefilled Syringes Among Persons Who Inject Drugs in San Diego, CA.

    Science.gov (United States)

    Armenta, Richard F; Roth, Alexis M; Wagner, Karla D; Strathdee, Steffanie A; Brodine, Stephanie K; Cuevas-Mota, Jazmine; Munoz, Fatima A; Garfein, Richard S

    2015-12-01

    Persons who inject drugs (PWID) are at increased risk for blood-borne virus (BBV) infections and overdose resulting from high-risk injecting practices. Studies of prefilled syringe use ([PFSU] using a syringe that already contained drug solution when it was obtained by the user), an injection practice previously described in Eastern Europe, suggest that it increases susceptibility to BBV. However, little is known about this practice in the USA. Data were obtained from an ongoing cohort study of PWID to determine the prevalence and assess correlates of PFSU in San Diego, CA. Baseline interviews assessed socio-demographics and drug use behaviors. Logistic regression was used to identify factors independently associated with ever using a prefilled syringe (yes/no). Participants (n = 574) were predominately males (73.9%) and white (50.9%) with a mean age of 43.4 years (range 18-80); 33.3% reported ever using prefilled syringes, although only 4.9% reported use in the past 6 months. In multivariable analyses, PFSU was independently associated with ever having a rushed injection due to police presence [adjusted odds ratio (AOR) = 2.51, 95% CI 1.66, 3.79], ever being in prison (AOR = 1.80, 95% CI 1.23, 2.63), injecting most often in public versus private places in the past 6 months (AOR = 1.66, 95% CI 1.11, 2.48), and injecting drugs in Mexico (AOR = 1.70, 95% CI 1.16, 2.49). Results indicate that a history of PFSU is common and associated with environmental factors that may also increase risk for adverse health outcomes. Studies are needed to better understand PFSU in order to develop interventions to prevent adverse outcomes associated with their use. PMID:26382653

  11. Exposure to tobacco, alcohol and drugs of abuse during pregnancy. A study of prevalence among pregnant women in Malaga (Spain).

    Science.gov (United States)

    Blasco-Alonso, Marta; González-Mesa, Ernesto; Gálvez Montes, Milagros; Lozano Bravo, Isabel; Merino Galdón, Federico; Cuenca Campos, Francisco; Marín Schiaffino, Gema; Pérez Torres, Sergio; Herrera Peral, José; Bellido Estévez, Inmaculada

    2015-01-01

    The prevalence of substance abuse in women who become pregnant is similar to that of the general population, resulting in a high fetal exposure rate during the most vulnerable period regarding neurodevelopment and organogenesis. The present study was intended to assess the level of prenatal exposure to tobacco, alcohol or illicit drugs in the city of Málaga (Spain). It was designed as a cross-sectional study, and based on the anonymous self-reports of participants. A total of 451 pregnant women were recruited in the first, second or third trimester. The prevalence in each of the quarters respectively was 21.2%, 18.5% and 13.3% for smoking, 40.7%, 23.1% and 17.1% for alcohol and 4.8%, 1.9% and 1.2% for cannabis. We also found that a higher educational level was associated with a lower consumption of tobacco (RR 0.659 [0.537-0.810] p<0.0001) and greater exposure to alcohol (RR 1.87 [1.30-2.69] p<0.0007). These results, particularly in regard to alcohol intake, are sufficiently alarming to alert obstetric care providers about the need to implement preventive measures. PMID:26132299

  12. Toxicology screening in urban trauma patients: drug prevalence and its relationship to trauma severity and management.

    Science.gov (United States)

    Sloan, E P; Zalenski, R J; Smith, R F; Sheaff, C M; Chen, E H; Keys, N I; Crescenzo, M; Barrett, J A; Berman, E

    1989-12-01

    Although toxicology screening is often used when treating trauma patients, its utility and significance remain controversial. Data from 623 toxicology screens performed in urban trauma center patients with mental status alterations are reported. The study patients were predominantly black and male, with a mean age of 32 (+/- 22) years. Overall, 86% of screens were positive. Substances of abuse, including ethanol, were noted in 525 (84%) of urine toxicology screens. Ethanol, cannabinoids, and cocaine were the drugs most commonly found in urine, with positivity noted in 53%, 37%, and 34% of screens. Serum analysis was 44% positive, with ethanol noted in 41% of patients. In blacks, the odds ratio of illicit drug use before trauma ranged from 1.9 to 4.2 (p less than 0.005), and in those aged 17 to 40 years, the odds ratio for illicit urine drugs ranged from 4.7 to 16.8 (p less than 0.001). In patients older than 40 years, the odds of a positive serum ethanol level were 1.7 times greater than in younger patients, and a level above 300 mg% was 3.8 times more likely in this age group (p less than 0.001). When serum ethanol was detected, the odds ratio of a head injury was 1.4 relative to patients without serum ethanol (p less than 0.06), and the odds ratio for abdominal injury was 1.6 for patients with serum ethanol (p less than 0.03). The odds of a TS less than 12 were 1.8 (p less than 0.05), and the odds of a GCS less than 12 were 3.3 (p less than 0.001) with ethanol levels greater than 100 mg%.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2593195

  13. Prevalence and Characteristics of Femoral Injection among Seattle-Area Injection Drug Users

    OpenAIRE

    Coffin, Phillip O; Coffin, Lara S.; Murphy, Shilo; Jenkins, Lindsay M.; Golden, Matthew R.

    2012-01-01

    Injection drug use (IDU) into central veins, most common among long-term IDUs with no other options, can lead to severe infectious, vascular, and traumatic medical consequences. To follow-up on anecdotal reports of femoral vein injection and related medical problems in Seattle, we analyzed data from the annual survey of a community-based syringe exchange program. A total of 276 (81%) of 343 program attendees completed the survey in August 2010. Among 248 IDUs, 66% were male, 78% white, and 86...

  14. Prevalence of malaria parasitemia and purchase of artemisinin-based combination therapies (ACTs among drug shop clients in two regions in Tanzania with ACT subsidies.

    Directory of Open Access Journals (Sweden)

    Melissa A Briggs

    Full Text Available BACKGROUND: Throughout Africa, many people seek care for malaria in private-sector drug shops where diagnostic testing is often unavailable. Recently, subsidized artemisinin-based combination therapies (ACTs, a first-line medication for uncomplicated malaria, were made available in these drug shops in Tanzania. This study assessed the prevalence of malaria among and purchase of ACTs by drug shop clients in the setting of a national ACT subsidy program and sub-national drug shop accreditation program. METHOD AND FINDINGS: A cross-sectional survey of drug shop clients was performed in two regions in Tanzania, one with a government drug shop accreditation program and one without, from March-May, 2012. Drug shops were randomly sampled from non-urban districts. Shop attendants were interviewed about their education, training, and accreditation status. Clients were interviewed about their symptoms and medication purchases, then underwent a limited physical examination and laboratory testing for malaria. Malaria prevalence and predictors of ACT purchase were assessed using univariate analysis and multiple logistic regression. Amongst 777 clients from 73 drug shops, the prevalence of laboratory-confirmed malaria was 12% (95% CI: 6-18%. Less than a third of clients with malaria had purchased ACTs, and less than a quarter of clients who purchased ACTs tested positive for malaria. Clients were more likely to have purchased ACTs if the participant was 5 years, experience (aOR: 2.8; 95% CI: 1.2-6.3. Having malaria was only a predictor of ACT purchase in the region with a drug shop accreditation program (aOR: 3.4; 95% CI: 1.5-7.4. CONCLUSION: Malaria is common amongst persons presenting to drug shops with a complaint of fever. The low proportion of persons with malaria purchasing ACTs, and the high proportion of ACTs going to persons without malaria demonstrates a need to better target who receives ACTs in these drug shops.

  15. The prevalence of trimetazidine use in athletes in Poland: excretion study after oral drug administration.

    Science.gov (United States)

    Jarek, Anna; Wójtowicz, Marzena; Kwiatkowska, Dorota; Kita, Monika; Turek-Lepa, Ewa; Chajewska, Katarzyna; Lewandowska-Pachecka, Sylwia; Pokrywka, Andrzej

    2014-01-01

    Stimulants, together with anabolic androgenic steroids, are regarded as one of the most popular doping substances in sport. Owing to a great variety of these substances and new designer drugs being introduced to the market, each year the World Anti-Doping Agency (WADA) updates the list of substances and methods prohibited in sport. On 1 January 2014, a new doping agent - trimetazidine (TMZ) - was added to the WADA Prohibited List. TMZ, a substance prohibited in competition, is classified in the S6b Specified Stimulant Group. TMZ is used as a well-known cardiologic drug with confirmed biochemical and clinical activity. According to knowledge of the pharmacology and mechanism of TMZ action, TMZ can be used by athletes to improve physical efficiency, especially in the case of endurance sports. This study presents the phenomena of TMZ use by Polish athletes involved in anti-doping control in the WADA-accredited laboratory in Warsaw (Poland) between 2008 and 2013. Samples were taken from the athletes of such disciplines as cycling, athletics, and triathlon. Moreover, the elimination study of TMZ has been conducted to establish the change of TMZ concentration in urine sample after oral administration of a single or double (during the long-term therapy) dose. TMZ was monitored in urine samples by gas chromatography-mass spectrometry-nitrogen phosphorus detection (GC-MS-NPD). PMID:25421604

  16. Prevalence of, and risk factors for, HIV, hepatitis B and C infections among men who inject image and performance enhancing drugs: a cross-sectional study

    OpenAIRE

    Hope, Vivian D.; McVeigh, Jim; Marongiu, Andrea; Evans-Brown, Michael; Smith, Josie; Kimergård, Andreas; Croxford, Sara; Beynon, Caryl M.; Parry, John V.; Bellis, Mark A; Ncube, Fortune

    2013-01-01

    Objective To describe drug use, sexual risks and the prevalence of blood-borne viral infections among men who inject image and performance enhancing drugs (IPEDs). Design A voluntary unlinked-anonymous cross-sectional biobehavioural survey. Setting 19 needle and syringe programmes across England and Wales. Participants 395 men who had injected IPEDs. Results Of the participants (median age 28 years), 36% had used IPEDs for

  17. Prevalence and factors associated with alcohol and drug-related disorders in prison: a French national study

    Directory of Open Access Journals (Sweden)

    Reynaud Michel

    2007-01-01

    Full Text Available Abstract Background Most studies measuring substance-use disorders in prisons focus on incoming or on remand prisoners and are generally restricted to drugs. However, there is evidence that substance use initiation or continuation occurs in prison, and that alcohol use is common. The aim of this study is 1 to assess prevalence of both drug and alcohol abuse and dependence (DAD/AAD in a national randomised cohort of French prisoners, short or long-term sentence 2 to assess the risk factors associated with DAD/AAD in prison. a stratified random strategy was used to select 1 23 prisons among the different types of prison 2 998 prisoners. Diagnoses were assessed according to a standardized procedure, each prisoner being assessed by two psychiatrists, one junior, using a structured interview (MINI 5 plus, and one senior, completing the procedure with an open clinical interview. At the end of the interview the clinicians met and agreed on a list of diagnoses. Cloninger's Temperament and Character Inventory (TCI was also used. Results More than a third of prisoners presented either AAD or DAD in the last 12 months. Cannabis was the most frequent drug and just under a fifth of prisoners had AAD. AAD and DAD were clearly different for the following: socio-demographic variables, childhood history, imprisonment characteristics, psychiatric comorbidity and Cloninger's TCI. Profiles of AAD in prison are similar to type II alcoholism. Conclusion Regular screening of AAD/DAD in prison, and specific treatment programmes taking into account differences between prisoners with an AAD and prisoners with a DAD should be a public health priority in prison

  18. Prevalence of co-occurring alcohol and other drug use in an Australian older adult mental health service.

    Science.gov (United States)

    Searby, Adam; Maude, Phil; McGrath, Ian

    2016-03-01

    Co-occurring mental illness and substance use disorder, known as dual diagnosis, is a significant challenge to mental health services. Few older adult specific alcohol and other drug treatment services exist, meaning older adult mental health services may become the default treatment option for many. Evidence suggests that dual diagnosis leads to substandard treatment outcomes, including higher rates of psychiatric relapse, higher costs of care and poorer treatment engagement. This paper explores the prevalence of co-occurring alcohol and other drug (AOD) use in an older adult community mental health service in inner Melbourne, Australia. This aim was accomplished by using a retrospective file audit of clinical intake assessments (n = 593) performed on consumers presenting to the service over a two-year period, June 2012-2014. Of consumers presenting to the service, 15.5% (n = 92) were assessed by clinicians as having co-occurring AOD use. Depression predominated in the dual diagnosis group as the primary mental health disorder. Dual diagnosis consumers in this sample were statistically more likely to be male and younger than their non-dual diagnosis counterparts. A limitation of this audit was the lack of implementation of screening tools, leaving assessment to clinical judgement or the interest of the clinician. This may also explain the discrepancy between the results of this study and previous work. Although appearing to be a relatively small percentage of assessments, the results accounted for 92 individuals with complex mental health, AOD and medical issues. Poor screening procedures in a population that is traditionally difficult to assess need to be rectified to meet the future challenges inherent in the ageing baby boomer generation, changing drug use trends and extended lifespans through harm reduction initiatives and medical advancements. PMID:26834037

  19. Distributional consequences of the transition from age-based to income-based prescription drug coverage in British Columbia, Canada.

    Science.gov (United States)

    Hanley, Gillian E; Morgan, Steve; Hurley, Jeremiah; van Doorslaer, Eddy

    2008-12-01

    In May, 2003, British Columbia transitioned from an age-based public drug program, with public subsidy primarily based on age, to an age-irrelevant income-based drug program, in which public subsidy is based primarily on household income. As one of the specific aims of the policy change was to improve fairness by increasing the extent to which payment for drugs is based on ability to pay, we measure the progressivity of pharmaceutical financing before and after the policy change in BC using Kakwani indices. Our results suggest that pharmaceutical financing became less regressive after the policy change. However, this decrease in regressivity arose primarily because high-income seniors were making greater direct contributions to pharmaceutical financing and not because low-income households were making smaller direct contributions. Our results also suggest that if the public financing of pharmaceuticals were maintained or increased, a change from age-based to income-based eligibility can unambiguously improve equity in finance. As populations in developed countries age, governments will increasingly consider reforms to publicly financed health-care programs with age-based eligibility. In assessing policy options, financial equity is likely to be a key consideration. These results suggest that income-based pharmacare can improve financial equity especially when implemented with a commitment to maintain or increase public funding for prescription drugs. PMID:18189226

  20. Effect of repeated mass drug administration with praziquantel and track and treat of taeniosis cases on the prevalence of taeniosis in Taenia solium endemic rural communities of Tanzania

    DEFF Research Database (Denmark)

    Braae, Uffe Christian; Magnussen, Pascal; Ndawi, Benedict;

    2016-01-01

    This study evaluated the effect of mass drug administration (MDA) with praziquantel administered to school-aged children (SAC) combined with ‘track and treat’ of taeniosis cases in the general population on the copro-antigen (Ag) prevalence of taeniosis. The study was conducted in 14 villages in ...

  1. Effect of repeated mass drug administration with praziquantel and track and treat of taeniosis cases on the prevalence of taeniosis in Taenia solium endemic rural communities of Tanzania

    DEFF Research Database (Denmark)

    Braae, Uffe Christian; Magnussen, Pascal; Ndawi, Benedict;

    This study evaluated the effect of mass drug administration (MDA) with praziquantel administered to school-aged children (SAC) combined with ‘track and treat’ of taeniosis cases on the prevalence of taeniosis. The study was conducted in 14 villages in Mbozi and Mbeya district, Tanzania. SAC recei...

  2. Fusion Canada

    International Nuclear Information System (INIS)

    This first issue of a quarterly newsletter announces the startup of the Tokamak de Varennes, describes Canada's national fusion program, and outlines the Canadian Fusion Fuels Technology Program. A map gives the location of the eleven principal fusion centres in Canada. (L.L.)

  3. PREVALENCE AND FACTORS ASSOCIATED WITH DRUG USE IN PREGNANT WOMEN ASSISTED IN PRIMARY CARE

    Directory of Open Access Journals (Sweden)

    Danielle Satie Kassada

    2015-01-01

    Full Text Available El objetivo del estudio fue identificar la prevalencia del consumo de drogas por mujeres embarazadas inscritas en la atención primaria; la clasificación de los medicamentos utilizados en función del riesgo de acuerdo a las drogas Food and Drug Administration y la agrupación usadas de acuerdo con la Clasificación Anatómica Terapéutica. Se trata de un estudio transversal analítico, en Maringá, Paraná que incluyó 394 embarazadas, en el periodo enero-julio de 2012, a través de entrevistas semi-estructuradas en los hogares. Los resultados mostraron que el 94,67% de las mujeres embarazadas usaron al menos un medicamento (2,03% sin receta médica y los fármacos más utilizados fueron antianémicos, seguido de los antieméticos y analgésicos. Los datos mostraron una relación estadísticamente significativa entre el uso de medicamentos y el estado civil, trimestre de embarazo, enfermedad crónica, enfermedad mental y la orientación de los profesionales de la salud primaria sobre los medicamentos. Es conocido por la complejidad de la cuestión que los profesionales de la salud, especialmente las enfermeras, desarrollar el papel importante de la educación continua y educación para la salud.

  4. Prevalence and occurrence rate of Mycobacterium tuberculosis Haarlem family multi-drug resistant in the worldwide population: A systematic review and meta-analysis

    Directory of Open Access Journals (Sweden)

    Rashid Ramazanzadeh

    2015-01-01

    Full Text Available Background: Transmission of Mycobacterium tuberculosis (M. tuberculosis can occur in different ways. Furthermore, drug resistant in M. tuberculosis family is a major problem that creates obstacles in treatment and control of tuberculosis (TB in the world. One of the most prevalent families of M. tuberculosis is Haarlem, and it is associated with drug resistant. Our objectives of this study were to determine the prevalence and occurrence rate of M. tuberculosis Haarlem family multi-drug resistant (MDR in the worldwide using meta-analysis based on a systematic review that performed on published articles. Materials and Methods: Data sources of this study were 78 original articles (2002-2012 that were published in the literatures in several databases including PubMed, Science Direct, Google Scholar, Biological abstracts, ISI web of knowledge and IranMedex. The articles were systematically reviewed for prevalence and rate of MDR. Data were analyzed using meta-analysis and random effects models with the software package Meta R, Version 2.13 (P < 0.10. Results: Final analysis included 28601 persons in 78 articles. The highest and lowest occurrence rate of Haarlem family in M. tuberculosis was in Hungary in 2006 (66.20% with negative MDR-TB and in China in 2010 (0.8%, respectively. From 2002 to 2012, the lowest rate of prevalence was in 2010, and the highest prevalence rate was in 2012. Also 1.076% were positive for MDR and 9.22% were negative (confidence interval: 95%.0020. Conclusion: Many articles and studies are performed in this field globally, and we only chose some of them. Further studies are needed to be done in this field. Our study showed that M. tuberculosis Haarlem family is prevalent in European countries. According to the presence of MDR that was seen in our results, effective control programs are needed to control the spread of drug-resistant strains, especially Haarlem family.

  5. Assessment on the prevalence and contributing factors of social drugs utilization among university of Gondar regular undergraduate students, maraki campus, 2013.

    Directory of Open Access Journals (Sweden)

    Desalegn Birara Mamo

    2014-08-01

    Full Text Available Introduction: According to WHO expert committee on drug dependence, drug abuse is persistent or sporadic excessive drug use in consistence with all unrelated to medical practice. Substances of abuse include controlled drugs (under international law and other substance with abuse potential but not subjected to international controls such as alcohol, khat, tobacco, and volatile substances. Social drug utilization has a negative impact on health and economic development of an individual and a country as a whole. Especially youngsters, who are the most productive section of the population, are suffering from the negative consequences of social drugs utilization. The objective of this study is to assess the prevalence and contributing factors of social drugs utilization in university of Gondar regular undergraduate students, Maraki campus, in 2013 academic year. The study design employed was mixed type where quantitative data was emphasized and the qualitative data was used to illustrate the quantitative data. Descriptive survey method using questionnaires, key informant interview and focus group discussion (FGD was conducted to collect the data. Utilization of social drugs among regular students of different departments of Maraki campus of University of Gondar was assessed using cross sectional study in 2013. Results: From a total of 682 respondents the majority 429(62.9% were found as utilizers and the rest 253(37.1% as non utilizers. Regarding contributing factors the result of this study showed that relaxation 125(29.1%, to increase performance 63(14.7%, and peer pressure 53(12.4% were the major contributing factors for students’ social drugs utilization. The prevalence of social drugs utilization was high (62.9%. Although the majority of utilizers started utilization before they join campus, peer pressure had a statistically significant association with social drugs utilization. All the concerned bodies should take part and work hand in hand

  6. Evaluation of the Prevalence of Hepatitis B, Hepatitis C, and HIV in Inmates with Drug-Related Convictions in Birjand, Iran in 2008

    Directory of Open Access Journals (Sweden)

    Gholamreza Sharifzadeh

    2010-01-01

    Full Text Available Background and Aims: Hepatitis B virus (HBV, hepatitis C virus (HCV, and human immunodeficiency virus (HIV are common infections among prisoners. Addicted prisoners are at a higher risk than the normal population for contracting these diseases. Many studies have reported higher prevalence rates of HBV, HCV, and HIV in prisoners. Because of this problem, this study was conducted to evaluate the serologic prevalence of these three diseases in prisoners convicted of drug-related crimes.Methods: A descriptive cross-sectional study was conducted on a random sample of prisoners with drug charges who were inmates in a prison in Birjand, Iran. Information was collected via questionnaire after obtaining prisoners' informed consent and blood samples were tested for hepatitis B surface antigen (HBsAg, antibodies to HCV (anti-HCV, and antibodies to HIV (anti-HIV. The results were analyzed by chi-square tests.Results: In this study, 358 prisoners were selected. 80.2% of prisoners were male, and 19.8% were female. The average age was 34.7±12 years. 39.1% were addicted to drugs, 54.2% were smokers, and 19.3% had tattoos. 8.4% had had extramarital intercourse, and 16.8% had had a sexually transmitted disease (STD in past. HBsAg, anti-HCV, and anti-HIV prevalence in these samples were 6.1%, 8.1%, and 0%, respectively. The prevalence rate of HBV in the addicted prisoners was 4.3%, and the rate in non-addicted prisoners was 7.3% (P = 0.24. The prevalence of HCV in addicted prisoners was 15.7%, and the prevalence in non-addicted prisoners was 3.2%; this difference was significant (P < 0.001. Furthermore, a significant difference between the prevalence of HBV and extramarital intercourse was noted (P < 0.005. A significant difference between HCV and transfusion, history of STDs, addiction, and tattooing was noted.Conclusions: The survey showed that HCV, HBV, and HIV prevalence rates in prisoners were 8.1%, 6.1%, 0%, respectively. The prevalence rates of HCV and HBV

  7. Effectiveness of two rounds of mass drug administration using DEC combined with albendazole on the prevalence of Brugia malayi

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    Santoso Santoso

    2015-11-01

    Full Text Available Background: Filariasis mass drug administration carried out for 5 consecutive years aims to reduce the prevalence rate of < 1%. Evaluation of treatment needs to be done, one of them with a finger blood survey. This study aims to assess the effectiveness of mass treatment and factors that influence. Methods:The study design was cross-sectional study. Blood sampling performed at night in four selected villages with a number of samples for blood tests as many as 1,209 people. Results:The number of microfilaria positive population of 10 people. The Village with the most number of cases (6 people with a microfilaria rate of 2.08% is Nibung Putih villages. History of fever, behavior taking medication, age and gender related to the incidence of filariasis. Regency East Tanjung Jabung is endemic filariasis because they found villages with Mf rate > 1%. Conclusions: Implementation of filariasis mass treatment was less effective because they can not derive filariasis endemicity. Recommendation: Implementation of filariasis mass treatment needs to be improved by increasing the participation of local community leaders in order to reach all levels of society, including isolated communities.

  8. Prevalence and impact of alcohol and other drug use disorders on sedation and mechanical ventilation: a retrospective study

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    Jenvey Wendy I

    2007-03-01

    Full Text Available Abstract Background Experience suggests that patients with alcohol and other drug use disorders (AOD are commonly cared for in our intensive care units (ICU's and require more sedation. We sought to determine the impact of AOD on sedation requirement and mechanical ventilation (MV duration. Methods Retrospective review of randomly selected records of adult patients undergoing MV in the medical ICU. Diagnoses of AOD were identified using strict criteria in Diagnostic and Statistical Manual of Mental Disorders, and through review of medical records and toxicology results. Results Of the 70 MV patients reviewed, 27 had AOD (39%. Implicated substances were alcohol in 22 patients, cocaine in 5, heroin in 2, opioids in 2, marijuana in 2. There was no difference between AOD and non-AOD patients in age, race, or reason for MV, but patients with AOD were more likely to be male (21 versus 15, p Conclusion The prevalence of AOD among medical ICU patients undergoing MV is high. Patients with AOD receive higher doses of sedation than their non-AOD counterparts to achieve similar RASS scores but do not undergo longer duration of MV.

  9. Using hepatitis C prevalence to estimate HIV epidemic potential among people who inject drugs in the Middle East and North Africa

    OpenAIRE

    Mumtaz, Ghina R; Weiss, Helen A.; Vickerman, Peter; Larke, Natasha; Abu-Raddad, Laith J

    2015-01-01

    Objectives: The objective of this study is to understand the association between HIV and hepatitis C virus (HCV) among people who inject drugs (PWIDs) in the Middle East and North Africa (MENA), and to estimate HIV epidemic potential among PWIDs using HCV prevalence. Design/methods: Using data from a systematic review of HIV and HCV among PWID in MENA, we conducted two analyses, stratified by HIV epidemic state: a meta-analysis of the risk ratio of HCV to HIV prevalence (RRHCV/HIV) using DerS...

  10. The prevalence of drug resistance in patients with HIV/AIDS attending to Imam Khomeini Hospital in Tehran, Iran during 2008-2009: letter to editor

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    Hajabdulbaghy M

    2011-07-01

    Full Text Available "nThe combinations of antiretroviral (ARV drugs have proven effective in controlling the progression of AIDS, but these benefits can be compromised by drug resistance. Thus, drug-resistance testing has become an important tool in the management of HIV-infected individuals.1 Drug resistance develops when mutations in the HIV virus proteins occur due to amino acid substitutions.2 Drug resistance testing is done in two ways: phenotypic test and genotypic test.3 In the first method, virus proliferation is measured in the presence of different concentrations of the drugs. In the second, the genetic structure of viral genome sequences are investigated.4 Although, the first case of HIV infection in Iran was identified 23 years ago (1988, there is still no study published on its drug resistance. The main purpose of this study was to determine the prevalence of drug resistance mutations in patients with HIV/AIDS attending Imam Khomeini Hospital in Tehran. The secondary objectives of the study were to determine the frequency of drug resistance to specific drugs such as nucleoside reverse transcriptase inhibitors (NRTIs, non-nucleoside reverse transcriptase inhibitors (NNRTIs and protease inhibitors (PI. We collected plasma samples from 25 patients with HIV/AIDS and immunological failure. After the extraction of the viral RNA from plasma, genomic sequencing was performed. Finally, the data for determining drug resistance were analyzed by the Stanford HIV Drug Resistance Database (http://hivdb.stanford.edu software. Out of the 25 patients under study, 20 were male (80% and five were female (20%. Routes of HIV transmission were: 56% by needle sharing among injecting drug users (IDUs, 20% through sexual contact, 12% through blood transfusions and 12% by unknown routes. High-level drug resistance for ARV drugs included: 24% to NRTIs, 28% to NNRTIs and zero percent to PI drugs. In addition, 15 patients had been infected with genotype A and 10 patients with

  11. Zoonotic potential of Giardia duodenalis and Cryptosporidium spp. and prevalence of intestinal parasites in young dogs from different populations on Prince Edward Island, Canada.

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    Uehlinger, Fabienne D; Greenwood, Spencer J; McClure, J Trenton; Conboy, Gary; O'Handley, Ryan; Barkema, Herman W

    2013-09-23

    The prevalence of Giardia duodenalis, Cryptosporidium spp. and other intestinal parasites was determined in dogs Dogs from the pet store had the highest prevalence of intestinal parasites (78%, 95% CI: 68-88%), followed by the private veterinary clinics (49%, 95% CI: 37-60%), and the local animal shelter (34%, 95% CI: 22-46%). The majority G. duodenalis belonged to host-adapted assemblages D (47%, 95% CI: 31-64%) and C (26%, 95% CI: 13-43%), respectively. Zoonotic assemblages A and B were isolated alone or in mixed infections from 16% (95% CI: 6-31%) of G. duodenalis-positive dogs. All Cryptosporidium spp. were the host-adapted C. canis. While host-adapted, non-zoonotic G. duodenalis genotypes were more common, the presence of G. duodenalis assemblages A and B, T. canis, and U. stenocephala suggests that these dogs may present a zoonotic risk. The zoonotic risk from Cryptosporidium-infected dogs was minimal. PMID:23601666

  12. Decreased prevalence of Plasmodium falciparum resistance markers to amodiaquine despite its wide scale use as ACT partner drug in Zanzibar

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    Fröberg Gabrielle

    2012-09-01

    Full Text Available Abstract Background Zanzibar has recently undergone a rapid decline in Plasmodium falciparum transmission following combined malaria control interventions with artemisinin-based combination therapy (ACT and integrated vector control. Artesunate-amodiaquine (ASAQ was implemented as first-line treatment for uncomplicated P. falciparum malaria in Zanzibar in 2003. Resistance to amodiaquine has been associated with the single nucleotide polymorphism (SNP alleles pfcrt 76T, pfmdr1 86Y, 184Y and 1246Y. An accumulation of these SNP alleles in the parasite population over time might threaten ASAQ efficacy. The aim of this study was to assess whether prolonged use of ASAQ as first-line anti-malarial treatment selects for P. falciparum SNPs associated with resistance to the ACT partner drug amodiaquine. Methods The individual as well as the combined SNP allele prevalence were compared in pre-treatment blood samples from patients with uncomplicated P. falciparum malaria enrolled in clinical trials conducted just prior to the introduction of ASAQ in 2002–2003 (n = 208 and seven years after wide scale use of ASAQ in 2010 (n = 122. Results There was a statistically significant decrease of pfcrt 76T (96–63%, pfmdr1 86Y (75–52%, 184Y (83–72%, 1246Y (28–16% and the most common haplotypes pfcrt/pfmdr1 TYYD (46–26% and TYYY (17–8%, while an increase of pfcrt/pfmdr1 KNFD (0.4–14% and KNYD (1–12%. Conclusions This is the first observation of a decreased prevalence of pfcrt 76T, pfmdr1 86Y, 184Y and 1246Y in an African setting after several years of extensive ASAQ use as first-line treatment for uncomplicated malaria. This may support sustained efficacy of ASAQ on Zanzibar, although it was unexpected considering that all these SNPs have previously been associated with amodiaquine resistance. The underlying factors of these results are unclear. Genetic dilution by imported P. falciparum parasites from mainland Tanzania, a de-selection by

  13. Mathematical Modeling of Hepatitis C Prevalence Reduction with Antiviral Treatment Scale-Up in Persons Who Inject Drugs in Metropolitan Chicago.

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    Desarae Echevarria

    Full Text Available New direct-acting antivirals (DAAs provide an opportunity to combat hepatitis C virus (HCV infection in persons who inject drugs (PWID. Here we use a mathematical model to predict the impact of a DAA-treatment scale-up on HCV prevalence among PWID and the estimated cost in metropolitan Chicago.To estimate the HCV antibody and HCV-RNA (chronic infection prevalence among the metropolitan Chicago PWID population, we used empirical data from three large epidemiological studies. Cost of DAAs is assumed $50,000 per person.Approximately 32,000 PWID reside in metropolitan Chicago with an estimated HCV-RNA prevalence of 47% or 15,040 cases. Approximately 22,000 PWID (69% of the total PWID population attend harm reduction (HR programs, such as syringe exchange programs, and have an estimated HCV-RNA prevalence of 30%. There are about 11,000 young PWID (<30 years old with an estimated HCV-RNA prevalence of 10% (PWID in these two subpopulations overlap. The model suggests that the following treatment scale-up is needed to reduce the baseline HCV-RNA prevalence by one-half over 10 years of treatment [cost per year, min-max in millions]: 35 per 1,000 [$50-$77] in the overall PWID population, 19 per 1,000 [$20-$26] for persons in HR programs, and 5 per 1,000 [$3-$4] for young PWID.Treatment scale-up could dramatically reduce the prevalence of chronic HCV infection among PWID in Chicago, who are the main reservoir for on-going HCV transmission. Focusing treatment on PWID attending HR programs and/or young PWID could have a significant impact on HCV prevalence in these subpopulations at an attainable cost.

  14. Injecting drug use among gay and bisexual men in Sydney: prevalence and associations with sexual risk practices and HIV and hepatitis C infection.

    Science.gov (United States)

    Lea, Toby; Mao, Limin; Bath, Nicky; Prestage, Garrett; Zablotska, Iryna; de Wit, John; Holt, Martin

    2013-05-01

    Injecting drug use is commonly reported among gay and bisexual men in Australia. We examined the prevalence and covariates of injecting drug use among men participating in the Sydney Gay Community Periodic Survey between 2004-06 and 2011. In 2004-06, data was collected about which drugs were injected, while in 2011, data was collected about hepatitis C (HCV) and esoteric sexual practices. In 2004-06, 5.6 % of men reported injecting drugs in the previous 6 months; 3.4 % reported methamphetamine injection and 0.4 % heroin injection. In 2011, men who injected drugs were less likely to be employed full-time, and more likely to be HCV-positive, HIV-positive, to have used party drugs for sex, and to have engaged in esoteric sexual practices. The strong associations between injecting drug use, sexual risk practices and blood-borne virus infection suggests the need for combined sexual health and harm reduction services for gay and bisexual men who inject drugs. PMID:23321949

  15. Prevalence and distribution of gastrointestinal nematodes on 32 organic and conventional commercial sheep farms in Ontario and Quebec, Canada (2006-2008).

    Science.gov (United States)

    Mederos, A; Fernández, S; VanLeeuwen, J; Peregrine, A S; Kelton, D; Menzies, P; LeBoeuf, A; Martin, R

    2010-06-24

    In order to characterize the epidemiology of sheep gastrointestinal nematodes in organic and conventional flocks in Canada, a longitudinal study was carried out from May 2006 to March 2008 on 32 purposively selected farms in Ontario (ON) and Quebec (QC): 8 certified organic (CO), 16 non-certified organic (NCO), and 8 conventional (C) farms. On each farm, 10 ewes and 10 female lambs were selected. Farm visits were undertaken monthly during the grazing season, and twice in the winter. At each visit, individual fecal samples were taken, and pasture samples were obtained during the grazing season. In addition, body condition score was recorded for all sheep. Fecal egg counts per gram of feces (EPGs) were determined for all fecal samples, and infective larvae (L(3)) were identified in fecal samples (lambs and ewes separately) and pasture samples from farms. Necropsies of 14 lambs from 7 of the 23 Ontario farms were performed at the end of the grazing season in 2006. The mean EPG for year 1 (May 2006 to March 2007) was 181 (range=0-9840) and 351 (range=0-18,940) for the ewes in ON and QC, respectively, and for the lambs was 509 (range=0-25,020) and 147 (range=0-3060) for ON and QC, respectively. During year 2 (April 2007 to March 2008), the mean EPG was 303 (range=0-21,160) and 512 (range=0-22,340) for the ewes in ON and QC, respectively, and for lambs was 460 (range=0-26,180) and 232 (range=0-8280) for ON and QC, respectively. Although the overall mean EPGs were not remarkably high, there were months of higher EPG such as May-June for ewes and July-August for lambs in both provinces. Pasture infectivity was highest in May-June and September. There was a general trend for the CO farms to have lower mean EPG than NCO and C farms. Fecal cultures demonstrated that the most predominant nematode genera were Teladorsagia sp., Haemonchus sp. and Trichostrongylus spp. Pasture infectivity was highest during June-July (984 L3/kg DM) in ON farms and September (mean=436 L3/kg DM) in

  16. Prevalence of Wuchereria Bancrofti Antigenemia and Associated Factors Among Children of School Age Born After Initiation of Mass Drug Administration with ivermectin and albendazole in Rufiji district, Tanzania

    OpenAIRE

    Clarer, Jones

    2012-01-01

    The National Lymphatic Filariasis (LF) Elimination Programme use Ivermectin and Albendazole mass drug administration (MDA) for the control of LF. Screening children of school age has successfully been used for mapping geographical distribution of LF worldwide. The implementation of MDA for LF in Rufiji district started in 2002 and up to 2011, nine rounds had been administered. The prevalence of LF after MDA was not known, thus this study aimed to screen children born during the period of prog...

  17. Prevalence and risk factors for Campylobacter spp., Salmonella spp., Coxiella burnetii, and Newcastle disease virus in feral pigeons (Columba livia) in public areas of Montreal, Canada.

    Science.gov (United States)

    Gabriele-Rivet, Vanessa; Fairbrother, Julie-Hélène; Tremblay, Donald; Harel, Josée; Côté, Nathalie; Arsenault, Julie

    2016-01-01

    Feral pigeons (Columbia livia) can harbor a range of zoonotic pathogens. A transversal study was undertaken to estimate the prevalence of feral pigeons infected by various pathogens in public areas in Montreal, Quebec. Cloacal swabs from captured birds were cultured for Salmonella spp. and Campylobacter spp. and tested by real-time polymerase chain reaction (RT-PCR) for the detection of Coxiella burnetii. An oropharyngeal swab was also submitted to real-time reverse-transcription polymerase chain reaction (RRT-PCR) for the detection of Newcastle disease virus. Among the 187 pigeons tested from 10 public areas, 9.1% (95% CI: 3.0 to 15.2) were positive for Campylobacter spp. with all strains identified as Campylobacter jejuni. The Campylobacter status of birds was not associated with individual characteristics of birds, with the exception of body score. None of the pigeons tested positive for the other pathogens. Direct or indirect contacts with feral pigeons may constitute a potential risk for Campylobacter infection in humans. PMID:26733736

  18. Prevalencia del consumo de medicamentos en la población adulta de Cataluña Prevalence of drug utilization in the adult population of Catalonia, Spain

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    S. Sans

    2002-04-01

    Full Text Available Objetivos: Describir la prevalencia de la utilización de medicamentos según factores sociodemográficos y estado de salud autopercibido en la población adulta. Métodos: Examen de salud transversal del estudio CRONICAT/MONICA-Cataluña realizado en 1994-1996 en una muestra aleatoria de la población general de 25 a 64 años. Se interrogó a 3.421 participantes (tasa de respuesta del 72% con cuestionario abierto sobre los medicamentos consumidos durante las dos semanas previas y otros hábitos de salud. Los medicamentos se codificaron posteriormente según la clasificación ATC (versión 1993. Resultados: Mayor proporción de mujeres (38% que de varones (26% autopercibió peor estado de salud (p Objectives: To describe the prevalence of drug utilization according to sociodemographic factors and self-perceived health in the adult population. Methods: Cross-sectional health survey of the CRONICAT/MONICA-Catalonia study carried out in 1994-96 in a random sample of the general population aged 25-64 years. A total of 3,421 participants (72% response rate were interviewed about drug consumption in the previous two weeks with an open questionnaire. The participants were also asked about other health habits. Drugs were subsequently classified according to the ATC classification (1993 version. Results: A higher proportion of women (38% than men (26% self-perceived poor health status (p < 0.001. Age-adjusted total drug utilization was 57% in men (95%CI: 55-59 and 76% in women (95%CI: 74-78. Excluding contraceptives, regular drug utilization was 35% in men (95%CI: 33-37 and 48% in women (95%CI: 46-51. Twenty-nine percent of men and 48% of women (p < 0.001 took more than one drug. Neither educational level nor marital status influenced drug utilization. Among men, drug consumption was higher in retired individuals and pensioners (68%; 95%CI: 62-74 than in active workers (54%; 95%CI: 52-57. The most frequently used drugs were those for the nervous system

  19. A systematic review of the prevalence and risk factors for adverse drug reactions in the elderly in the acute care setting

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    Alhawassi TM

    2014-12-01

    Full Text Available Tariq M Alhawassi,1,2 Ines Krass,1 Beata Bajorek,3,4 Lisa G Pont5 1Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia; 2College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 3Graduate School of Health – Pharmacy, University of Technology Sydney, 4Pharmacy Department, Royal North Shore Hospital, 5Sydney Nursing School, University of Sydney, Sydney, NSW, Australia Abstract: Adverse drug reactions (ADRs are an important health issue. While prevalence and risk factors associated with ADRs in the general adult population have been well documented, much less is known about ADRs in the elderly population. The aim of this study was to review the published literature to estimate the prevalence of ADRs in the elderly in the acute care setting and identify factors associated with an increased risk of an ADR in the elderly. A systematic review of studies published between 2003 and 2013 was conducted in the Cochrane Database of Systematic Reviews, EMBASE, Google Scholar and MEDLINE. Key search terms included: “adverse drug reactions”, “adverse effects”, “elderly patients and hospital admission”, “drug therapy”, “drug adverse effects”, “drug related”, “aged”, “older patients”, “geriatric”, “hospitalization”, and “emergency admissions”. For inclusion in the review, studies had to focus on ADRs in the elderly and had to include an explicit definition of what was considered an ADR and/or an explicit assessment of causality, and a clear description of the method used for ADR identification, and had to describe factors associated with an increased risk of an ADR. Fourteen hospital-based observational studies exploring ADRs in the elderly in the acute care setting were eligible for inclusion in this review. The mean prevalence of ADRs in the elderly in the studies included in this review was 11.0% (95% confidence interval [CI]: 5.1%–16.8%. The median prevalence of ADRs leading to

  20. Prevalence of resistance to second-line tuberculosis drug among multidrug-resistant tuberculosis patients in Viet Nam, 2011

    Science.gov (United States)

    Tran, Huong Thi Giang; Bui, Quyen Thi Tu

    2016-01-01

    Introduction Extensively drug-resistant tuberculosis (XDR-TB) represents an emerging public health problem worldwide. According to the World Health Organization, an estimated 9.7% of multidrug-resistant TB (MDR-TB) cases are defined as XDR-TB globally. The objective of this study was to determine the prevalence of drug resistance to second-line TB drugs among MDR-TB cases detected in the Fourth National Anti-Tuberculosis Drug Resistance Survey in Viet Nam. Methods Eighty clusters of TB cases were selected using a probability-proportion-to-size approach. To identify MDR-TB cases, drug susceptibility testing (DST) was performed for the four major first-line TB drugs. DST of second-line drugs (ofloxacin, amikacin, kanamycin, capreomycin) was performed on isolates from MDR-TB cases to identify pre-XDR and XDR cases. Results A total of 1629 smear-positive TB cases were eligible for culture and DST. Of those, DST results for first-line drugs were available for 1312 cases, and 91 (6.9%) had MDR-TB. Second-line DST results were available for 84 of these cases. Of those, 15 cases (17.9%) had ofloxacin resistance and 6.0% were resistant to kanamycin and capreomycin. Five MDR-TB cases (6.0%) met the criteria of XDR-TB. Conclusion This survey provides the first estimates of the proportion of XDR-TB among MDR-TB cases in Viet Nam and provides important information for local policies regarding second-line DST. Local policies and programmes that are geared towards TB prevention, early diagnosis and treatment with effective regimens are of high importance. PMID:27508089

  1. An association between anti-platelet drug use and reduced cancer prevalence in diabetic patients: results from the Vermont Diabetes Information System Study

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    Ramos-Nino Maria E

    2010-06-01

    Full Text Available Abstract Background Diabetes is associated with an increased risk of several malignancies. Both diabetic patients and patients with cancer have an increase in platelet reactivity and platelet activation has recently emerged as a potential mediator of cancer progression. Drug therapies, such as aspirin, that reduce platelet reactivity reduce both cardiovascular and cancer risk. Methods We performed a cross-sectional analysis to assess the association between history of cancer and current anti-platelet drug use in a primary care population of adults with diabetes enrolled in the Vermont Diabetes Information System. Results Self-reported characteristics, medical history, and a complete medication list were recorded on 1007 diabetic adults. Fifty percent of diabetic patients used an anti-platelet drug. In unadjusted analysis, no association was seen between anti-platelet drug use and cancer history (OR = 0.93; P = .70. Platelet inhibitor use was associated with a decreased patient-reported history of malignancy in a multivariate logistic regression adjusted for age, sex, body mass index, comorbidity, and number of medications (OR = 0.66; CI 0.44-0.99; P = .045. Similar odds of association were seen in both males and females, and for aspirin and non-aspirin platelet inhibitor therapy. Conclusions Our data suggest an association between anti-platelet drug use and reduced cancer prevalence in patients with diabetes. Given the potentially large implications of our observations in the diabetic population, further studies are required to determine if this association is causal.

  2. Sustained reduction in prevalence of lymphatic filariasis infection in spite of missed rounds of mass drug administration in an area under mosquito nets for malaria control

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    Shimada Masaaki

    2011-05-01

    Full Text Available Abstract Background The Global Programme to Eliminate Lymphatic Filariasis (GPELF was established by the World Health Organisation (WHO in 2000 with the goal of eliminating lymphatic filariasis (LF as a public health problem globally by 2020. Mass drug administration (MDA of antifilarial drugs is the principal strategy recommended for global elimination. Kenya launched a National Programme for Elimination of Lymphatic Filariasis (NPELF in Coast Region in 2002. During the same year a longitudinal research project to monitor trends of LF infection during MDA started in a highly endemic area in Malindi District. High coverage of insecticide treated nets (ITNs in the coastal region has been associated with dramatic decline in hospital admissions due to malaria; high usage of ITNs is also expected to have an impact on LF infection, also transmitted by mosquitoes. Results Four rounds of MDA with diethylcarbamazine citrate (DEC and albendazole were given to 8 study villages over an 8-year period. Although annual MDA was not administered for several years the overall prevalence of microfilariae declined significantly from 20.9% in 2002 to 0.9% in 2009. Similarly, the prevalence of filarial antigenaemia declined from 34.6% in 2002 to 10.8% in 2009. All the examined children born since the start of the programme were negative for filarial antigen in 2009. Conclusions Despite the fact that the study villages missed MDA in some of the years, significant reductions in infection prevalence and intensity were observed at each survey. More importantly, there were no rebounds in infection prevalence between treatment rounds. However, because of confounding variables such as insecticide-treated bed nets (ITNs, it is difficult to attribute the reduction to MDA alone as ITNs can lead to a significant reduction in exposure to filariasis vectors. The results indicate that national LF elimination programmes should be encouraged to continue provision of MDA albeit

  3. Violence and Drug Use in Rural Teens: National Prevalence Estimates from the 2003 Youth Risk Behavior Survey

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    Johnson, Andrew O.; Mink, Michael D.; Harun, Nusrat; Moore, Charity G.; Martin, Amy B.; Bennett, Kevin J.

    2008-01-01

    Objectives: The purpose of this study was to compare national estimates of drug use and exposure to violence between rural and urban teens. Methods: Twenty-eight dependent variables from the 2003 Youth Risk Behavior Survey were used to compare violent activities, victimization, suicidal behavior, tobacco use, alcohol use, and illegal drug use…

  4. Prevalence and structural correlates of gender based violence among a prospective cohort of female sex workers

    OpenAIRE

    Shannon, Kate; Kerr, T.; Strathdee, S.A.; Shoveller, J; Montaner, J S; Tyndall, M W

    2009-01-01

    Objective To examine the prevalence and structural correlates of gender based violence against female sex workers in an environment of criminalised prostitution. Design Prospective observational study. Setting Vancouver, Canada during 2006-8. Participants Female sex workers 14 years of age or older (inclusive of transgender women) who used illicit drugs (excluding marijuana) and engaged in street level sex work. Main outcome measure Self reported gender based violence. Results Of 267 female s...

  5. HIV, Hepatitis B and C among people who inject drugs: high prevalence of HIV and Hepatitis C RNA positive infections observed in Delhi, India

    OpenAIRE

    Ray Saraswati, Lopamudra; Sarna, Avina; Sebastian, Mary Philip; Sharma, Vartika; Madan, Ira; Thior, Ibou; Pulerwitz, Julie; Tun, Waimar

    2015-01-01

    Background India has large PWID (persons who inject drugs) population estimated at 177,000. PWIDs are at high risk for HIV, Hepatitis B (HBV) and Hepatitis C (HCV) infections. We report the prevalence of HIV, HBV and HCV infections and correlates of HIV-HCV co-infection among male PWIDs in Delhi. Methods 3748 male PWIDs were recruited for a longitudinal HIV incidence study. Participants were tested for HBV and HCV infections at their first follow-up visit (FV1) using serum HBV-surface antigen...

  6. Prevalence and behavioural risks for HIV and HCV infections in a population of drug users of Dakar, Senegal: the ANRS 12243 UDSEN study

    Science.gov (United States)

    Leprêtre, Annie; Ba, Idrissa; Lacombe, Karine; Maynart, Maryvonne; Toufik, Abdalla; Ndiaye, Ousseynou; Kane, Coumba Toure; Gozlan, Joël; Tine, Judicaël; Ndoye, Ibrahim; Raguin, Gilles; Girard, Pierre-Marie

    2015-01-01

    Objectives Data on the extent of drug use and associated HIV, hepatitis C and hepatitis B infection in West Africa are lacking. The objectives of ANRS12244 UDSEN study were to estimate the size of the heroin and/or cocaine drug user (DU) population living in the Dakar area (Senegal), and assess the prevalence and risk factors of HIV, hepatitis C virus (HCV) and hepatitis B virus (HBV), including behavioural determinants in this population, in order to set up an integrated prevention and treatment programme for DUs. Design and methods A capture-recapture method was applied for population size estimation, whereas the respondent-driven sampling (RDS) method was used to recruit a sample of DUs living in the Dakar area and determine HIV, HBV and HCV prevalence. Behavioural data were gathered during face-to-face interviews, and blood samples were collected on dried blood spots for analysis in a central laboratory. Data analysis was performed using the RDS analysis tool, and risk factors were determined by logistic regression. Access to laboratory results was organized for the participants. Results The size of the DU population in the Dakar area was estimated to reach 1324 (95% confidence interval (95% CI: 1281–1367)). Based on the 506 DUs included in the study, the HIV, HCV and HBV prevalence were 5.2% (95% CI: 3.8–6.3), 23.3% (95% CI: 21.2–25.2) and 7.9% (95% CI: 5.2–11.1), respectively. In people who inject drugs (PWID), prevalence levels increased to 9.4% for HIV and 38.9% for HCV (p=0.001 when compared to those who never injected). Women were more at risk of being HIV infected (prevalence: 13.04% versus 2.97% in males, p=0.001). Being PWID was a risk factor for HCV and HIV infection (odds ratio, OR: 2.7, 95% CI: 1.7–4.3, and OR: 4.3, 95% CI: 1.7–10.7, respectively), whereas older age and female sex were additional risk factors for HIV infection (10% increase per year of age, p=0.03 and OR: 4.9, 95% CI: 1.6–156, respectively). No specific determinant was

  7. Prevalence and behavioural risks for HIV and HCV infections in a population of drug users of Dakar, Senegal: the ANRS 12243 UDSEN study

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    Annie Leprêtre

    2015-05-01

    Full Text Available Objectives: Data on the extent of drug use and associated HIV, hepatitis C and hepatitis B infection in West Africa are lacking. The objectives of ANRS12244 UDSEN study were to estimate the size of the heroin and/or cocaine drug user (DU population living in the Dakar area (Senegal, and assess the prevalence and risk factors of HIV, hepatitis C virus (HCV and hepatitis B virus (HBV, including behavioural determinants in this population, in order to set up an integrated prevention and treatment programme for DUs. Design and methods: A capture-recapture method was applied for population size estimation, whereas the respondent-driven sampling (RDS method was used to recruit a sample of DUs living in the Dakar area and determine HIV, HBV and HCV prevalence. Behavioural data were gathered during face-to-face interviews, and blood samples were collected on dried blood spots for analysis in a central laboratory. Data analysis was performed using the RDS analysis tool, and risk factors were determined by logistic regression. Access to laboratory results was organized for the participants. Results: The size of the DU population in the Dakar area was estimated to reach 1324 (95% confidence interval (95% CI: 1281–1367. Based on the 506 DUs included in the study, the HIV, HCV and HBV prevalence were 5.2% (95% CI: 3.8–6.3, 23.3% (95% CI: 21.2–25.2 and 7.9% (95% CI: 5.2–11.1, respectively. In people who inject drugs (PWID, prevalence levels increased to 9.4% for HIV and 38.9% for HCV (p=0.001 when compared to those who never injected. Women were more at risk of being HIV infected (prevalence: 13.04% versus 2.97% in males, p=0.001. Being PWID was a risk factor for HCV and HIV infection (odds ratio, OR: 2.7, 95% CI: 1.7–4.3, and OR: 4.3, 95% CI: 1.7–10.7, respectively, whereas older age and female sex were additional risk factors for HIV infection (10% increase per year of age, p=0.03 and OR: 4.9, 95% CI: 1.6–156, respectively. No specific

  8. Prevalence of antibodies to hepatitis C virus and association with intravenous drug abuse and tattooing in a national prison in Norway.

    Science.gov (United States)

    Holsen, D S; Harthug, S; Myrmel, H

    1993-09-01

    A study was performed in order to determine the prevalence of anti-hepatitis C virus (HCV) antibodies, the risk factors for HCV infection and the markers of hepatic disease in a population of prisoners. Of 101 new prisoners admitted to a Norwegian national prison over a three month period, 70 were included in the study, of whom 32 (46%) were anti-HCV positive. Intravenous drug abuse was the predominant risk factor for HCV infection, although a history of tattooing was found by logistic regression analysis to be a significant risk factor independent of intravenous drug abuse. Most anti-HCV positive prisoners had a history of previous incarcerations. Among the anti-HCV positive subjects, increased alanine aminotransferase (> 50 U/l) was found in 23 (72%). HCV infection was the major cause of hepatic abnormalities in the study population. Only 15 (47%) of the anti-HCV positive prisoners reported knowledge of previous hepatic disease. PMID:7694850

  9. Addiction Treatment and Stable Housing among a Cohort of Injection Drug Users

    OpenAIRE

    Palepu, Anita; Marshall, Brandon D. L.; Lai, Calvin; Wood, Evan; Kerr, Thomas

    2010-01-01

    Background Unstable housing and homelessness is prevalent among injection drug users (IDU). We sought to examine whether accessing addiction treatment was associated with attaining stable housing in a prospective cohort of IDU in Vancouver, Canada. Methods We used data collected via the Vancouver Injection Drug User Study (VIDUS) between December 2005 and April 2010. Attaining stable housing was defined as two consecutive “stable housing” designations (i.e., living in an apartment or house) d...

  10. Prevalence of decreased susceptibility to triclosan in Salmonella enterica isolates from animals and humans and association with multiple drug resistance

    OpenAIRE

    Copitch, Justin L.; Whitehead, Rebekah N.; Webber, Mark A.

    2010-01-01

    Abstract Previous laboratory studies have implicated triclosan as a possible selective force driving resistance to multiple antibiotics and have identified a number of triclosan resistance mechanisms in Salmonella enterica. The aim of this work was to determine the prevalence of decreased susceptibility to triclosan in a panel of human and animal isolates of S. enterica and to identify the mechanisms of triclosan resistance in these strains. Over 400 animal and human isolates of no...

  11. The prevalence of isolated hepatitis B core antibody and its related risk factors among male injected drug users in Isfahan prisons

    Directory of Open Access Journals (Sweden)

    Kiana Shirani

    2015-01-01

    Full Text Available Background: The prevalence of isolated hepatitis B core antibody (anti-HBc varies between 1% and 30% in different populations. Isolated anti-HBc-positive patients who suffer from occult hepatitis B virus (HBV infection have the potential to transmit HBV infection. So isolated anti-HBc screening is a valuable tool to prevent HBV transmission. Considering the importance of isolated anti-HBc screening and high prevalence of HBV among injected drug users (IDU prisoners, we designed this study to evaluate the isolated anti-HBc positivity among inmates with the history of IDU in our area. Materials and Methods: We did this cross-sectional study from September 2009 to March 2010 among volunteer male IDU prisoners in Isfahan. Blood samples were taken from all of subjects and tested for HBV markers. Then a questionnaire containing socio-demographic, drug histories and high risk behaviors information was completed for all participants. Data analysis was done utilizing univariate analysis and multiple logistic regressions. A P < 0.05 was considered significant. Results: Totally 970 male IDU prisoners (mean age 32.6 ± 8.1 were included in our study. The prevalence of isolated HBc Ab was 4.5%. Isolated anti-HBc significantly was related to tooth filling (OR: 2.62, CI: 1.20-7.14 and imprisonment (OR: 3.95, CI: 1.39-11.18 . We couldn′t find any relationship between isolated anti-HBc positivity and addiction duration, incarceration frequency, recent incarceration duration or number of injection per month. Conclusion: For screening high risk groups in parallel with hepatitis B surface antigen (HBsAg, hepatitis B surface antibody (HBsAb and other viral markers, maybe it is better to check HBcAb too, because isolated HBcAb-positive patients may have occult hepatitis B infection which could transfer the infection to others.

  12. Bleeding peptic ulcer. Prevalence of Helicobacter pylori and use of nonsteroidal anti-inflammatory drugs/acetylsalicylic acid

    DEFF Research Database (Denmark)

    Vestergard, A.; Bredahl, K.; Muckadell, O.B. de;

    2009-01-01

    INTRODUCTION: Helicobacter pylori (HP) infection and use of nonsteroidal anti-inflammatory drugs (NSAIDs)/acetyl salicylic acid (ASA) are risk factors for bleeding peptic ulcer. HP eradication reduces the risk of rebleeding. Antibiotics, proton pump inhibitors (PPI) and presence of blood...

  13. Prevalence, drug-induced hepatotoxicity, and mortality among patients multi-infected with HIV, tuberculosis, and hepatitis virus

    OpenAIRE

    Pingzheng Mo; Qi Zhu; Caroline Teter; Rongrong Yang; Liping Deng; Yajun Yan; Jun Chen; Jie Zeng; Xi-en Gui

    2014-01-01

    Objectives: To investigate the prevalence, incidence of abnormal liver function tests (LFTs), and mortality during anti-TB treatment in patients multi-infected with HIV, tuberculosis (TB), and hepatitis virus (hepatitis B virus (HBV) and hepatitis C virus (HCV)). Methods: Three hundred and sixty-one HIV-positive TB patients were enrolled and divided into an HIV/TB group, HIV/TB/HBV group, and HIV/TB/HCV group; 1013 HIV-negative TB patients were selected randomly as controls. Results: On...

  14. Transmitted drug resistance in the CFAR network of integrated clinical systems cohort: prevalence and effects on pre-therapy CD4 and viral load.

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    Art F Y Poon

    Full Text Available Human immunodeficiency virus type 1 (HIV-1 genomes often carry one or more mutations associated with drug resistance upon transmission into a therapy-naïve individual. We assessed the prevalence and clinical significance of transmitted drug resistance (TDR in chronically-infected therapy-naïve patients enrolled in a multi-center cohort in North America. Pre-therapy clinical significance was quantified by plasma viral load (pVL and CD4+ cell count (CD4 at baseline. Naïve bulk sequences of HIV-1 protease and reverse transcriptase (RT were screened for resistance mutations as defined by the World Health Organization surveillance list. The overall prevalence of TDR was 14.2%. We used a Bayesian network to identify co-transmission of TDR mutations in clusters associated with specific drugs or drug classes. Aggregate effects of mutations by drug class were estimated by fitting linear models of pVL and CD4 on weighted sums over TDR mutations according to the Stanford HIV Database algorithm. Transmitted resistance to both classes of reverse transcriptase inhibitors was significantly associated with lower CD4, but had opposing effects on pVL. In contrast, position-specific analyses of TDR mutations revealed substantial effects on CD4 and pVL at several residue positions that were being masked in the aggregate analyses, and significant interaction effects as well. Residue positions in RT with predominant effects on CD4 or pVL (D67 and M184 were re-evaluated in causal models using an inverse probability-weighting scheme to address the problem of confounding by other mutations and demographic or risk factors. We found that causal effect estimates of mutations M184V/I (-1.7 log₁₀pVL and D67N/G (-2.1[³√CD4] and 0.4 log₁₀pVL were compensated by K103N/S and K219Q/E/N/R. As TDR becomes an increasing dilemma in this modern era of highly-active antiretroviral therapy, these results have immediate significance for the clinical management of HIV-1

  15. Teenage pregnancy: use of drugs in the third trimester and prevalence of psychiatric disorders Gravidez na adolescência: uso de drogas no terceiro trimestre e prevalência de transtornos psiquiátricos

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    Sandro Sendin Mitsuhiro

    2006-06-01

    Full Text Available OBJECTIVE: To determine the prevalence of psychiatric disorders during pregnancy, the prevalence of cocaine and marijuana use during the third trimester of gestation and the socio-demographic characteristics of a population of low-income teenagers. METHOD: One thousand pregnant teenagers were evaluated using the Composite International Diagnostic Interview, and a socio-demographic and socio-economic questionnaire at the obstetric center of a public hospital in São Paulo, Brazil. Hair sample was collected for analysis. RESULTS: Of the 1000 pregnant teenagers interviewed, 53.6% were poor, 90.4% were unemployed, 92.5% were financially dependant and 60.2% dropped out of school. Those using drugs during the third trimester of pregnancy were equal to 6% (marijuana: 4%, cocaine: 1.7%, both: 0.3%. Those having at least one psychiatric disorder equaled 27.6%. The most frequent diagnoses were depression (12.9%, posttraumatic stress disorder (10.0% and anxiety disorders (5.6%. DISCUSSION: Unstructured families, dropping out of school, unemployment and a low level of professional training are all contributing factors to the maintenance of an unfavorable socio-economic environment in which there is a high prevalence of cocaine and marijuana use during the third trimester of pregnancy and an abnormally high incidence of psychiatric disorders.OBJETIVO: Determinar, em adolescentes de baixa renda, a prevalência de transtornos psiquiátricos durante a gravidez, a prevalência de uso de cocaína e maconha no terceiro trimestre de gestação e descrever suas características sociodemográficas. MÉTODO: Mil adolescentes grávidas foram avaliadas por meio do Composite International Diagnostic Interview e de um questionário sociodemográfico e socioeconômico no centro obstétrico de um hospital público de São Paulo. Dessas, foi colhida amostra para análise de fios de cabelo. RESULTADOS: Das mil pacientes entrevistadas, 53,6% têm baixa renda, 60,2% abandonaram

  16. The prevalence and degree of resistance of Plasmodium falciparum to first-line antimalarial drugs: an in vitro study from a malaria endemic region in Yemen

    International Nuclear Information System (INIS)

    Unpublished studies on antimalarial drug efficacy have found low levels of chloroquine resistance in Yemen. This study was carried out to determine the current prevalence of drug resistance in Plasmodium falciparum in Yemen to the main anti-malarial drugs and to determine the effective concentration (EC) values. The WHO standard protocol was used for the selection of subjects, collection of blood samples, culture techniques, examination of post-culture blood slides and interpretation of results. The in vitro micro-test Mark III was used for assessing susceptibility of P. falciparum isolates. The criteria for blood parasite density was met by 219 P. falciparum malaria patients. Chloroquine resistance was found in 47% of isolated P. falciparum schizonts. Mefloquine resistance was found in 5.2%. In addition, the EC50 and EC95 values in blood that inhibited schizont maturation in resistant isolates were higher than the normal therapeutic level for mefloquine. No resistance occurred against quinine or artemisinin, with no growth at the cut off level for quinine and inhibition at low concentrations of artemisinin. Our study confirmed the occurrence of chloroquine-resistant P. falciparum and a slow increase in the rate of this resistance will increase further and spread over all the foci of malaria in Yemen. The low rate of chloroquine-resistant P. falciparum was lower than that reported in Africa or Southeast Asia, but is the first report of the mefloquine resistance in Yemen. Finally, the isolates were sensitive to low concentrations of quinine and artemisinin. (author)

  17. HIV and HCV prevalence and incarceration-related risks among injecting drug users in three West Bank governorates.

    Science.gov (United States)

    Štulhofer, Aleksandar; Jwehan, Isam; AbuRabie, Randa

    2016-09-01

    In the Middle East, the HIV epidemic among injecting drug users (IDUs) seems to be in an early phase, which increases the importance of prevention and systematic risk surveillance. To gain information about HIV and HCV infection rates among IDUs in the West Bank, a biobehavioral survey was conducted using time-location sampling in the Ramallah, Hebron, and Bethlehem governorates in 2013. The researchers recruited 288 Palestinian IDUs ages 16-64 (Mage = 39.2, SD = 11.11). While no HIV cases were found in the sample, 41% of participants tested positive for HCV. Imprisonment was common among participants (83%), so we explored the association of incarceration experience with HCV infection and HIV testing. In multivariate assessments, incarceration was shown to increase the odds of being infected with HCV and ever tested for HIV. HIV prevention should be strengthened in West Bank prisons and correctional facilities, and imprisonment for drug use re-examined. PMID:26936370

  18. Evaluation of the Prevalence of Drug Abuse and Smoking in Parents of Children with Attention Deficit Hyperactivity Disorder

    OpenAIRE

    Parvaresh, Nooshin; Mazhari, Shahrzad; Mohamadi, Neda; Mohamadi, Najmeh

    2016-01-01

    Background Attention deficit hyperactivity disorder (ADHD) affects 5% of children. In addition to pharmacotherapy, non-drug treatments such as appropriate parenting are also very important in the treatment of these children. Diagnosis and treatment of parents with psychiatric disorders and substance abuse and evaluation of the frequency of these disorders in parents is critical. Methods In this case-control study, 200 parents were studied. The target population included parents of 7 to 12 yea...

  19. Common Genotypes of Hepatitis B virus prevalent in Injecting drug abusers (addicts of North West Frontier Province of Pakistan

    Directory of Open Access Journals (Sweden)

    Alam Muhammad

    2007-06-01

    Full Text Available Abstract Background The epidemiological significance of Hepatitis B virus genotypes has been well established and becoming an essential concern day by day however, much little is known about the mixed infection with more than one Hepatitis B virus genotypes and their clinical relevance. Methods Intravenous drug abusers are considered as a major risk group for the acquisition and transmission of blood borne infections like hepatitis B, however, in Pakistan, no such data has ever been reported about the epidemiology of HBV and its genotypes in Injecting Drug Users. 250 individuals were analyzed for hepatitis B virus genotypes after prior screening with serological assay for the detection of HBsAg. Results 56 (22.4% individuals were found positive on ELSIA for HBsAg. The genotype distribution was found to be as: genotype D, 62.5%; genotype A, 8.92% while 28.57% individuals were found to be infected with a mixture of genotype A and D. Conclusion There is an urgent need of the time to develop public health care policies with special emphasis towards the control of HBV transmission through high risk groups especially Injecting Drug Users.

  20. Prevalence of Alcohol Consumption and Hazardous Drinking, Tobacco and Drug Use in Urban Tanzania, and Their Associated Risk Factors

    Directory of Open Access Journals (Sweden)

    Nicola Singleton

    2009-07-01

    Full Text Available Evidence suggests substance abuse in Tanzania is a growing public health problem. A random sample of 899 adults aged 15-59 in two urban sites of differing levels of poverty surveyed alcohol, tobacco and illicit substance use. Rates of substance use were 17.2%. 8.7% and 0.8% for alcohol, tobacco and cannabis, respectively. Living in the less affluent area was associated with higher lifetime rates of tobacco and alcohol use. Substance use is less prevalent in Tanzania than in richer countries, but lifetime consumption is higher in poorer areas. The association of substance use with a range of socio-economic factors warrants further research.

  1. Drug resistance and genetic characteristics of clinical isolates of staphylococci in Myanmar: high prevalence of PVL among methicillin-susceptible Staphylococcus aureus belonging to various sequence types

    Directory of Open Access Journals (Sweden)

    M.S. Aung

    2016-03-01

    Full Text Available Prevalence, drug resistance and genetic characteristics were analysed for a total of 128 clinical isolates of staphylococci obtained from a tertiary hospital in Myanmar. The dominant species were S. aureus (39% and S. haemolyticus (35%, followed by S. epidermidis (6% and S. saprophyticus (5%. The majority of S. haemolyticus isolates (71.1% harboured mecA, showing high resistance rates to ampicillin, cephalosporins, erythromycin and levofloxacin, while methicillin-resistant S. aureus (MRSA was only 8% (four isolates among S. aureus with type IV SCCmec. Panton-Valentine leukocidin (PVL genes were detected in 20 isolates of S. aureus (40%, among which only one isolate was MRSA belonging to sequence type (ST 88/agr-III/coa-IIIa, and the other 19 methicillin-susceptible S. aureus (MSSA isolates were classified into six STs (ST88, ST121, ST1153, ST1155, ST1930, ST3206. An ST1153 MSSA isolate with PVL was revealed to belong to a novel coa type, XIIIa. ST121 S. aureus was the most common in the PVL-positive MSSA (47%, 9/19, harbouring genes of bone sialoprotein and variant of elastin binding protein as a distinctive feature. Although PVL-positive MSSA was susceptible to most of the antimicrobial agents examined, ST1930 isolates were resistant to erythromycin and levofloxacin. ST59 PVL-negative MRSA and MSSA had more resistance genes than other MRSA and PVL-positive MSSA, showing resistance to more antimicrobial agents. This study indicated higher prevalence of mecA associated with multiple drug resistance in S. haemolyticus than in S. aureus, and dissemination of PVL genes to multiple clones of MSSA, with ST121 being dominant, among hospital isolates in Myanmar.

  2. Drug resistance and genetic characteristics of clinical isolates of staphylococci in Myanmar: high prevalence of PVL among methicillin-susceptible Staphylococcus aureus belonging to various sequence types.

    Science.gov (United States)

    Aung, M S; Zi, H; Nwe, K M; Maw, W W; Aung, M T; Min, W W; Nyein, N; Kawaguchiya, M; Urushibara, N; Sumi, A; Kobayashi, N

    2016-03-01

    Prevalence, drug resistance and genetic characteristics were analysed for a total of 128 clinical isolates of staphylococci obtained from a tertiary hospital in Myanmar. The dominant species were S. aureus (39%) and S. haemolyticus (35%), followed by S. epidermidis (6%) and S. saprophyticus (5%). The majority of S. haemolyticus isolates (71.1%) harboured mecA, showing high resistance rates to ampicillin, cephalosporins, erythromycin and levofloxacin, while methicillin-resistant S. aureus (MRSA) was only 8% (four isolates) among S. aureus with type IV SCCmec. Panton-Valentine leukocidin (PVL) genes were detected in 20 isolates of S. aureus (40%), among which only one isolate was MRSA belonging to sequence type (ST) 88/agr-III/coa-IIIa, and the other 19 methicillin-susceptible S. aureus (MSSA) isolates were classified into six STs (ST88, ST121, ST1153, ST1155, ST1930, ST3206). An ST1153 MSSA isolate with PVL was revealed to belong to a novel coa type, XIIIa. ST121 S. aureus was the most common in the PVL-positive MSSA (47%, 9/19), harbouring genes of bone sialoprotein and variant of elastin binding protein as a distinctive feature. Although PVL-positive MSSA was susceptible to most of the antimicrobial agents examined, ST1930 isolates were resistant to erythromycin and levofloxacin. ST59 PVL-negative MRSA and MSSA had more resistance genes than other MRSA and PVL-positive MSSA, showing resistance to more antimicrobial agents. This study indicated higher prevalence of mecA associated with multiple drug resistance in S. haemolyticus than in S. aureus, and dissemination of PVL genes to multiple clones of MSSA, with ST121 being dominant, among hospital isolates in Myanmar. PMID:27257489

  3. The prevalence of human immunodeficiency virus type 1 and hepatitis C virus among injection drug users who use high risk inner-city locales in Miami, Florida

    Directory of Open Access Journals (Sweden)

    Clyde B McCoy

    2004-12-01

    Full Text Available In order to estimate the prevalence of human immunodeficiency virus type 1 (HIV-1 and hepatitis C virus (HCV co-infection in hard-to-reach intravenous drug users, 199 subjects from high-risk inner-city locales, the so called "shooting galleries", were consented, interviewed, and tested in Miami, FL, US. Positive HIV-1 status was based on repeatedly reactive ELISA and confirmatory Western Blot. Positive HCV status was based on reactive ELISA and confirmatory polymerase chain reaction techniques. Overall, 50 (25% were not infected with either virus, 61 (31% were HIV-1/HCV co-infected, 17 (8% infected by HIV-1 only, and 71 (36% infected by HCV only. The results of the multivariable analyses showed that more years using heroin was the only significant risk factor for HCV only infection (odds ratio = 1.15; 95% confidence interval = 1.07, 1.24 and for HIV-1/HCV co-infection (odds ratio = 1.17; 95% confidence interval = 1.09, 1.26. This paper demonstrates that HIV-1/HCV co-infection is highly prevalent among so called "shooting galleries".

  4. Prevalence of selected sexually and blood-borne infections in Injecting drug abuser inmates of bandar abbas and roodan correction facilities, Iran, 2002

    Directory of Open Access Journals (Sweden)

    Parivash Davoodian

    2009-10-01

    Full Text Available Human Immunodeficiency Virus (HIV and other blood borne viral infections like hepatitis B virus (HBV and hepatitis C virus (HCV are major health issues especially in young and growing population of developing countries. All around the globe correctional facilities are known as potential source of spreading such disease. During summer 2002, HIV, HCV antibodies, hepatitis B surface (HBs antigen and rapid plasma reagin (RPR test were checked in venous blood samples of 252 injecting drug abuser prisoners from correctional facilities in southern Iran. Overall HIV, HCV and HBV infection rate was 15.1% (38/249, 64.8% (163/249, and 4.7% (12/249, respectively. HCV infection rate of HIV positive cases was 94% (35/38. All RPR results were negative. Duration of previous drug abuse and imprisonment were correlated with HIV and HCV infection (p value = 0.0003 and 0.015 & p value =0.02 and 0.02. Considering the higher prevalence of HIV and HCV infection in correctional facilities compared to general population of Iran, warrants immediate multidisciplinary approaches targeted at controlling further spread of these infections primarily among prisoners and secondarily preventing them to act as carrier to general population.

  5. Risk of HIV and Hepatitis B and C Over Time Among Men Who Inject Image and Performance Enhancing Drugs in England and Wales: Results From Cross-Sectional Prevalence Surveys, 1992–2013

    OpenAIRE

    Hope, VD; R. Harris; McVeigh, J.; Cullen, KJ; J. Smith; Parry, JV; DeAngelis, D; Ncube, F

    2016-01-01

    Background: Infection risks among people who inject drugs (PWID) are widely recognized, but few studies have focused on image and performance enhancing drugs (IPEDs). Globally, concern about IPED injection has increased and, in the United Kingdom, IPED injectors have become the largest group using Needle and Syringe Programmes. Blood-borne virus prevalence trends among IPED injectors are explored. Method: Data from 2 surveys of IPED injectors (2010–2011; 2012–2013) and the national bio-behavi...

  6. Patterns of HIV prevalence among injecting drug users in the cross-border area of Lang Son Province, Vietnam, and Ning Ming County, Guangxi Province, China

    Directory of Open Access Journals (Sweden)

    Hoang Tran V

    2005-08-01

    Full Text Available Abstract Background To assess patterns of injecting drug use and HIV prevalence among injecting drug users (IDUs in an international border area along a major heroin trans-shipment route. Methods Cross-sectional surveys of IDUs in 5 sites in Lang Son Province, Vietnam (n = 348 and 3 sites in Ning Ming County, Guangxi Province, China (n = 308. Respondents were recruited through peer referral ("snowball" methods in both countries, and also from officially recorded lists of IDUs in Vietnam. A risk behavior questionnaire was administered and HIV counseling and testing conducted. Results Participants in both countries were largely male, in their 20s, and unmarried. A majority of subjects in both countries were members of ethnic minority groups. There were strong geographic gradients for length of drug injecting and for HIV seroprevalence. Both mean years injecting and HIV seroprevalence declined from the Vietnamese site farthest from the border to the Chinese site farthest from the border. 10.6% of participants in China and 24.5% of participants in Vietnam reported crossing the international border in the 6 months prior to interview. Crossing the border by IDUs was associated with (1 distance from the border, (2 being a member of an ethnic minority group, and (3 being HIV seropositive among Chinese participants. Conclusion Reducing the international spread of HIV among IDUs will require programs at the global, regional, national, and "local cross border" levels. At the local cross border level, the programs should be coordinated on both sides of the border and on a sufficient scale that IDUs will be able to readily obtain clean injection equipment on the other side of the border as well as in their country of residence.

  7. Canada: Health system review.

    Science.gov (United States)

    Marchildon, Gregory

    2013-01-01

    Canada is a high-income country with a population of 33 million people. Its economic performance has been solid despite the recession that began in 2008. Life expectancy in Canada continues to rise and is high compared with most OECD countries; however, infant and maternal mortality rates tend to be worse than in countries such as Australia, France and Sweden. About 70% of total health expenditure comes from the general tax revenues of the federal, provincial and territorial governments. Most public revenues for health are used to provide universal medicare (medically necessary hospital and physician services that are free at the point of service for residents) and to subsidise the costs of outpatient prescription drugs and long-term care. Health care costs continue to grow at a faster rate than the economy and government revenue, largely driven by spending on prescription drugs. In the last five years, however, growth rates in pharmaceutical spending have been matched by hospital spending and overtaken by physician spending, mainly due to increased provider remuneration. The governance, organization and delivery of health services is highly decentralized, with the provinces and territories responsible for administering medicare and planning health services. In the last ten years there have been no major pan-Canadian health reform initiatives but individual provinces and territories have focused on reorganizing or fine tuning their regional health systems and improving the quality, timeliness and patient experience of primary, acute and chronic care. The medicare system has been effective in providing Canadians with financial protection against hospital and physician costs. However, the narrow scope of services covered under medicare has produced important gaps in coverage and equitable access may be a challenge in these areas. PMID:23628429

  8. HIV Prevalence among Aboriginal British Columbians

    Directory of Open Access Journals (Sweden)

    Strathdee Steffanie

    2005-12-01

    Full Text Available Abstract Context There is considerable concern about the spread of HIV disease among Aboriginal peoples in British Columbia. Objective To estimate the number of Aboriginal British Columbians infected with HIV. Design and setting A population-based analysis of Aboriginal men and women in British Columbia, Canada from 1980 to 2001. Participants Epidemic curves were fit for gay and bisexual men, injection drug users, men and women aged 15 to 49 years and persons over 50 years of age. Main outcome measures HIV prevalence for the total Aboriginal population was modeled using the UNAIDS/WHO Estimation and Projection Package (EPP. Monte Carlo simulation was used to estimate potential number infected for select transmission group in 2001. Results A total of 170,025 Aboriginals resided in British Columbia in 2001, of whom 69% were 15 years and older. Of these 1,691 (range 1,479 – 1,955 men and women aged 15 years and over were living with HIV with overall prevalence ranging from 1.26% to 1.66%. The majority of the persons infected were men. Injection drug users (range 1,202 – 1,744 and gay and bisexual men (range 145, 232 contributed the greatest number of infections. Few persons infected were from low risk populations. Conclusion More than 1 in every 100 Aboriginals aged 15 years and over was living with HIV in 2001. Culturally appropriate approaches are needed to tailor effective HIV interventions to this community.

  9. High prevalence of extensively drug-resistant and metallo beta-lactamase-producing clinical Acinetobacter baumannii in Iran.

    Science.gov (United States)

    Maspi, Hossein; Mahmoodzadeh Hosseini, Hamideh; Amin, Mohsen; Imani Fooladi, Abbas Ali

    2016-09-01

    Acinetobacter species particularly Acinetobacter baumannii (A. baumannii) have been widely reported as broad-spectrum antibiotic resistant pathogens. Expression of various types of metallo beta-lactamases (MBL), classified as Ambler class B, has been associated with carbapenem resistance. Here, we attempted to assess the frequency of extensively drug-resistant (XDR) and MBL-producing A. baumannii among clinical isolates. 86 clinical A. baumannii strains were collected from 2014 to 2015 and their susceptibility to meropenem (10 μg), imipenem (10 μg), azteronem (30 μg), pipracillin (100 μg) tazobactam (110 μg), tobramycin (10 μg), fosfomycin (200 μg), rifampicin (5 μg), colistin (10 μg), tigecycline (15 μg), sulbactam/ampicillin (10 μg + 10 μg) and polymixin B (300 U) was evaluated using disk diffusion method. The MBL-producing isolates were screened using combined disc diffusion method. Furthermore, the presence of blaVIM, blaIMP, blaSPM, blaGIM, blaSIM and blaNDM was detected by PCR. 34.9% of isolates were recovered from bronchoalveolar lavage (BAL). 81 (94.2%) and 62 (71.2%) isolates were multidrug resistance (MDR) and XDR, respectively. 44 (51.2%) and 65 (75.6%) isolates were MBL-producing strains with resistance to imipenem and meropenem, respectively. 2 (2.3%), 13 (15.1%), 2 (2.3%), 4 (4.7%) and 2 (2.3%) isolates carried blaVIM, blaIMP, blaSPM, blaGIM and blaSIM genes, respectively. Our data showed that the rate of XDR and MBL A. baumannii is on the rise. PMID:27448835

  10. Prevalence of drug resistance mutations in HAART patients infected with HIV-1 CRF06_cpx in Estonia.

    Science.gov (United States)

    Avi, Radko; Pauskar, Merit; Karki, Tõnis; Kallas, Eveli; Jõgeda, Ene-Ly; Margus, Tõnu; Huik, Kristi; Lutsar, Irja

    2016-03-01

    HIV-1 drug resistance mutations (DRMs) and substitutions were assessed after the failure of the first line non-nucleoside reverse transcriptase inhibitors (NNRTIs) + 2 nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) treatment regimens (efavirenz [EFV] + lamivudine[3TC] + zidovudine [ZDV] vs. EFV + 3TC + ddI) among the HIV-1 CRF06_cpx infected subjects in Estonia. HIV-1 genomic RNA was sequenced; DRMs and amino acid substitutions were compared in 44 treatment naïve and 45 first-line NNRTI + 2 NRTI treatment failed patients consisting of EFV + 3TC + ZDV (n = 17) and EFV + 3TC + didanosine[ddI] (n = 21) therapy failed sub-populations. At least one DRM was found in 78% of treatment experienced patients. The most common NRTI mutations were M184V (80%), L74V (31%), L74I (17%), K219E (9%), and M184I (9%), NNRTI mutations were K103N (83%), P225H (14%), L100I (11%), and Y188L (11%), reflecting generally the similar pattern of DRMs to that seen in treatment failed subtype B viruses. Sub-population analysis revealed that EFV + 3TC + ddI failed patients had more DRMs compared to EFV + 3TC + ZDV failed patients, especially the ddI DRM L74IV and several additional NNRTI DRMs. Additionally, CRF06_cpx specific mutation E179V and substitutions R32K, K122E, and V200AE were also detected in treatment experienced population. After the failure of the first-line EFV + 3TC + ddI therapy HIV-1 CRF06_cpx viruses develop additional NRTI and NNRTI mutations compared to EFV + 3TC + ZDV regimen. Therefore the usage of EFV + 3TC + ddI in this subtype decreases the options for next regimens containing abacavir, and NNRTI class agents. PMID:26291050

  11. Syringe exchange in Canada: good but not enough to stem the HIV tide.

    Science.gov (United States)

    Hankins, C A

    1998-04-01

    This article provides a historical perspective on the development of syringe exchange in Canada, the Canadian legal and policy context, evaluation and monitoring strategies, and current challenges facing HIV prevention efforts among injecting drug users. Despite the fact that it is legal to sell, exchange, or provide an IDU with a syringe and there are no laws in Canada requiring a physician's prescription to justify possession of a syringe, policy development and programming have not been adequate to hold HIV at bay in several cities across the country. Although there have been concerted efforts by syringe and needle exchange programs to increase the supply of injecting equipment, HIV prevalence continues to rise, provoking a rethinking of the role of syringe exchange. In a coordinated strategy for HIV prevention among drug users in Canada, needle and syringe exchange is not itself in question; however, ghettoization and needle quota systems may have had an adverse impact on prevention programming. A national action plan has been developed which aims to decentralize both methadone maintenance and syringe and needle exchange programs, increase access to detoxification and treatment modalities, and advocate for changes in the criminal justice system and law enforcement practices. PMID:9596380

  12. Prevalence, genetic diversity and antiretroviral drugs resistance-associated mutations among untreated HIV-1-infected pregnant women in Gabon, central Africa

    Directory of Open Access Journals (Sweden)

    Caron Mélanie

    2012-03-01

    Full Text Available Abstract Background In Africa, the wide genetic diversity of HIV has resulted in emergence of new strains, rapid spread of this virus in sub-Saharan populations and therefore spread of the HIV epidemic throughout the continent. Methods To determine the prevalence of antibodies to HIV among a high-risk population in Gabon, 1098 and 2916 samples were collected from pregnant women in 2005 and 2008, respectively. HIV genotypes were evaluated in 107 HIV-1-positive samples to determine the circulating subtypes of strains and their resistance to antiretroviral drugs (ARVs. Results The seroprevalences were 6.3% in 2005 and 6.0% in 2008. The main subtype was recombinant CRF02_AG (46.7%, followed by the subtypes A (19.6%, G (10.3%, F (4.7%, H (1.9% and D (0.9% and the complex recombinants CRF06_cpx (1.9% and CRF11_cpx (1.9%; 12.1% of subtypes could not be characterized. Analysis of ARVs resistance to the protease and reverse transcriptase coding regions showed mutations associated with extensive subtype polymorphism. In the present study, the HIV strains showed reduced susceptibility to ARVs (2.8%, particularly to protease inhibitors (1.9% and nucleoside reverse transcriptase inhibitors (0.9%. Conclusions The evolving genetic diversity of HIV calls for continuous monitoring of its molecular epidemiology in Gabon and in other central African countries.

  13. The prevalence and determinants of drug-resistance-associated mutations in the HIV-1-infected MSM population of Henan Province in China.

    Science.gov (United States)

    Hou, Li-Juan; Wang, Hong-Wei; Duan, Shu-Peng; Zhuo, Ya; Zhou, Yan-Cai; Wu, Hong-Jie; Shen, Bao-Sheng

    2015-08-01

    To estimate the prevalence of human immunodeficiency virus (HIV) drug resistance (DR) in a population of men who have sex with men (MSM) from Henan Province of China and to identify the DR-associated HIV-1 mutations in these MSM. The HIV-positive status of the MSM subjects in this study was confirmed using ELISA and Western blotting. The MSM subjects were classified into non-treatment group (n = 106) and treatment group (n = 313). CD4(+) T-lymphocyte counts were obtained by flow cytometry, and viral load was measured by branched DNA (bDNA) signal amplification assay. HIV-1 genotypic resistance tests were performed by sequence analysis of the HIV-1 protease and reverse transcriptase genes. In the non-treatment group, 15 patients (14.2 %) displayed DR to non-nucleoside reverse transcriptase inhibitor (NNRTI). In the treatment group, the failure rate of viral suppression was 38.33 % and the DR rate was 33.2 %, which was higher than the rate observed in the non-treatment group (P homosexual orientation are the major risk factors for DR in this MSM population (all P homosexual orientation were identified as the risk factors for DR in the MSM population from Henan Province in China. PMID:26077516

  14. Prevalence and seroincidence of hepatitis B and hepatitis C infection in high risk people who inject drugs in china and Thailand.

    Science.gov (United States)

    Jackson, J Brooks; Wei, Liu; Liping, Fu; Aramrattana, Apinun; Celentano, David D; Walshe, Louise; Xing, Yi; Richardson, Paul; Jun, Ma; Beauchamp, Geetha; Donnell, Deborah; Ruan, Yuhua; Ma, Liying; Metzger, David; Shao, Yiming

    2014-01-01

    We determined the prevalence and incidence of HBV and HCV infection in people who inject drugs (PWIDs) at high risk for HIV in China and Thailand and determined the association of HBV and HCV incidence with urine opiate test results and with short-term versus long-term buprenorphine-naloxone (B-N) treatment use in a randomized clinical trial (HPTN 058). 13.8% of 1049 PWIDs in China and 13.9% of 201 PWIDs in Thailand were HBsAg positive at baseline. Among HBsAg negative participants, the HBsAg incidence rate was 2.7/100 person years in China and 0/100 person years in Thailand. 81.9% of 1049 PWIDs in China and 59.7% of 201 in Thailand were HCV antibody positive at baseline. The HCV confirmed seroincidence rate among HCV antibody negative PWIDs was 22/100 person years in China and 4.6/100 person years in Thailand. Incident HBsAg was not significantly different in the short-term versus long-term B-N arm in China or Thailand. Participants with positive opiate results in at least 75% of their urines during the time period were at increased risk of incident HBsAg (HR = 5.22; 95% CI, 1.08 to 25.22; P = 0.04) in China, but not incident HCV conversion in China or Thailand. PMID:24860664

  15. Potential Consequences of Essential Drug Shortages in Canada: Brain Abscess due to Nocardia farcinica Associated with Dapsone Prophylaxis for Pneumocystis jirovecii Pneumonia

    OpenAIRE

    Wuerz, Terry C; Bow, Eric J; Matthew D Seftel

    2013-01-01

    In 2012, Canadian pharmacies experienced a shortage of trimethoprim-sulfamethoxazole tablets. Drug shortages may result in unintended clinical consequences such as infection with pathogens against which the alternative medication is ineffective. This is highlighted in the present article, which describes a case of brain abscess due to Nocardia species that developed while receiving dapsone as an alternative for prophylaxis against Pneumocystis jirovecii pneumonia in a highly immune-suppressed...

  16. Event-Level Analysis of Anal Sex Roles and Sex Drug Use Among Gay and Bisexual Men in Vancouver, British Columbia, Canada.

    Science.gov (United States)

    Rich, Ashleigh J; Lachowsky, Nathan J; Cui, Zishan; Sereda, Paul; Lal, Allan; Moore, David M; Hogg, Robert S; Roth, Eric A

    2016-08-01

    This study analyzed event-level partnership data from a computer-assisted survey of 719 gay and bisexual men (GBM) enrolled in the Momentum Health Study to delineate potential linkages between anal sex roles and the so-called "sex drugs," i.e., erectile dysfunction drugs (EDD), poppers, and crystal methamphetamine. Univariable and multivariable analyses using generalized linear mixed models with logit link function with sexual encounters (n = 2514) as the unit of analysis tested four hypotheses: (1) EDD are significantly associated with insertive anal sex roles, (2) poppers are significantly associated with receptive anal sex, (3) both poppers and EDD are significantly associated with anal sexual versatility, and (4) crystal methamphetamine is significantly associated with all anal sex roles. Data for survey respondents and their sexual partners allowed testing these hypotheses for both anal sex partners in the same encounter. Multivariable results supported the first three hypotheses. Crystal methamphetamine was significantly associated with all anal sex roles in the univariable models, but not significant in any multivariable ones. Other multivariable significant variables included attending group sex events, venue where first met, and self-described sexual orientation. Results indicate that GBM sex-drug use behavior features rational decision-making strategies linked to anal sex roles. They also suggest that more research on anal sex roles, particularly versatility, is needed, and that sexual behavior research can benefit from partnership analysis. PMID:26525571

  17. 9 CFR 93.419 - Sheep and goats from Canada.

    Science.gov (United States)

    2010-01-01

    ... requirements established by the U.S. Food and Drug Administration at 21 CFR 589.2000, and, before the animal's... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Sheep and goats from Canada. 93.419... FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Ruminants Canada 8 § 93.419 Sheep and goats...

  18. Prevalence of drug resistance and culture-positive rate among microorganisms isolated from patients with ocular infections over a 4-year period

    Directory of Open Access Journals (Sweden)

    Shimizu Y

    2013-04-01

    Full Text Available Yusuke Shimizu,1 Hiroshi Toshida,1 Rio Honda,1 Asaki Matsui,1 Toshihiko Ohta,1 Yousuke Asada,2 Akira Murakami2 1Department of Ophthalmology, Juntendo University Shizuoka Hospital, Shizuoka, Japan; 2Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan Purpose: To investigate the microbial isolates from patients with ocular infections and the trend in the emergence of levofloxacin-resistant strains over the past four years from 2006 to 2009 retrospectively. Patients and methods: The subjects were 242 patients with ocular infections or traumas treated in our hospital including outpatients, inpatients, and emergency room patients. Most of them needed urgent care presenting with eye complaints, traumas, or decreased vision. Clinical samples were obtained from discharges, corneal, conjunctival tissues or vitreous fluid or aqueous humor, and cultured. Items for assessment included the patient’s age, the diagnosis, the prevalence of isolated bacteria, and the results of susceptibility tests for levofloxacin (LVFX cefamezin (CEZ, gentamicin (GM and vancomycin. This information was obtained from the patients’ medical records. Results: There were 156 male patients and 86 female patients who were aged from 2 months old to 94 years old and mean age was 56.8 ± 24.2 years. Of the 242 patients, 78 (32.2% had positive cultures. The culture-positive rate was significantly higher in male patients than female in total (P = 0.002 and in patients with corneal perforation (P = 0.005. Corneal perforation was the highest culture-positive rate (60.0%, followed by orbital cellulitis (56.5%, blepharitis (50.0%, dacryoadenitis (45.5%, conjunctivitis (38.2%, infectious corneal ulcer (28.5% and endophthalmitis (24.7%. LVFX-resistant strains accounted for 40 out of a total of 122 strains (32.8%, and the minimum inhibitory concentration (MIC was significantly higher in LVFX and GM compared with the other antibiotics. There were no vancomycin

  19. A prospective study on prevalence of adverse drug reactions due to antibiotics usage in otolaryngology department of a tertiary care hospital in North India

    Directory of Open Access Journals (Sweden)

    Farhan Ahmad Khan

    2013-10-01

    Full Text Available Background: Polypharmacy, advancing age and longer duration of hospital stay are the factors responsible for adverse drug reactions (ADRs. This study has attempted to analyze the pattern of antimicrobial prescription in OPD & IPD of the Otolaryngology department and to detect, document, assess and report the suspected ADRs due to antibiotic use and preparation of guidelines to minimize the incidence of ADRs. Methods: A prospective study conducted at the TMMC&RC on patients aged >40 years, who visited the Otolaryngology department over a period of 5 months. Suspected ADRs were assessed for causality and severity using Naranjo’s probability scale and modified Hartwig’s criteria, respectively. Results: Out of 1200, 925 prescriptions were analyzed. Most patients were from 41-60 age (59.45% followed by 61-80 age (37.29% and least from >80 yr (3.24%. But the incidence of ADRs were found to be higher in patients of >80 yr age group n=8 (26.66%. The most commonly prescribed antibacterials were β-Lactams (64.61%. Out of 925 prescriptions studied, only 94 were found to have 154 ADRs. The most commonly identified ADRs were Gastrointestinal 47.40%, followed by Neurotoxicity 24.67%, cutaneous reactions 20.12%, Hepatic 4.54% and Kidney 3.24%. 74.67% of the ADRs were probable and 20.77% were possible type and only 4.54% were definite. 74.67% ADRs were found to be type A, and 25.32% type B. Conclusions: Our study showed that prevalence of ADRs was highest in elder age group and diarrhea was the most common ADR found. Therefore elderly patients should be given special attention when prescribing medications to avoid clinically significant harmful consequences. Minimizing unnecessary antibiotic use by even a small percentage could significantly reduce the immediate and direct risks of drug-related adverse events in individual patients. [Int J Basic Clin Pharmacol 2013; 2(5.000: 548-553

  20. Teenage pregnancy: use of drugs in the third trimester and prevalence of psychiatric disorders Gravidez na adolescência: uso de drogas no terceiro trimestre e prevalência de transtornos psiquiátricos

    OpenAIRE

    Sandro Sendin Mitsuhiro; Elisa Chalem; Marina Moraes Barros; Ruth Guinsburg; Ronaldo Laranjeira

    2006-01-01

    OBJECTIVE: To determine the prevalence of psychiatric disorders during pregnancy, the prevalence of cocaine and marijuana use during the third trimester of gestation and the socio-demographic characteristics of a population of low-income teenagers. METHOD: One thousand pregnant teenagers were evaluated using the Composite International Diagnostic Interview, and a socio-demographic and socio-economic questionnaire at the obstetric center of a public hospital in São Paulo, Brazil. Hair sample w...

  1. Addressing Household Food Insecurity in Canada - Position Statement and Recommendations - Dietitians of Canada.

    Science.gov (United States)

    2016-07-01

    POSITION STATEMENT It is the position of Dietitians of Canada that household food insecurity is a serious public health issue with profound effects on physical and mental health and social well-being. All households in Canada must have sufficient income for secure access to nutritious food after paying for other basic necessities. Given the alarming prevalence, severity and impact of household food insecurity in Canada, Dietitians of Canada calls for a pan-Canadian, government-led strategy to specifically reduce food insecurity at the household level, including policies that address the unique challenges of household food insecurity among Indigenous Peoples. Regular monitoring of the prevalence and severity of household food insecurity across all of Canada is required. Research must continue to address gaps in knowledge about household vulnerability to food insecurity and to evaluate the impact of policies developed to eliminate household food insecurity in Canada. Dietitians of Canada recommends: Development and implementation of a pan-Canadian government-led strategy that includes coordinated policies and programs, to ensure all households have consistent and sufficient income to be able to pay for basic needs, including food. Implementation of a federally-supported strategy to comprehensively address the additional and unique challenges related to household food insecurity among Indigenous Peoples, including assurance of food sovereignty, with access to lands and resources, for acquiring traditional/country foods, as well as improved access to more affordable and healthy store-bought/market foods in First Nation reserves and northern and remote communities. Commitment to mandatory, annual monitoring and reporting of the prevalence of marginal, moderate and severe household food insecurity in each province and territory across Canada, including among vulnerable populations, as well as regular evaluation of the impact of poverty reduction and protocols for

  2. Evaluating the Cost-effectiveness of Pharmaceuticals in Canada

    OpenAIRE

    Katherine Boothe

    2016-01-01

    Canada adopted guidelines for the economic evaluation of pharmaceuticals in 1994, and a central process for drug assessment in 2003. The context and the way the issue reached the agenda in the two time periods differed. The guidelines were adopted amidst growing academic interest in methods for economic evaluation of pharmaceuticals in Canada and internationally, and were first promoted by an entrepreneur from the pharmaceutical industry. The Common Drug Review (CDR) was adopted in a context ...

  3. Assessment on the prevalence and contributing factors of social drugs utilization among university of Gondar regular undergraduate students, maraki campus, 2013.

    OpenAIRE

    Desalegn Birara Mamo; Deribew Abebaw Abuhay; Belayneh Kefale Gelaw; Gobezie Temesgen Tegegne

    2014-01-01

    Introduction: According to WHO expert committee on drug dependence, drug abuse is persistent or sporadic excessive drug use in consistence with all unrelated to medical practice. Substances of abuse include controlled drugs (under international law) and other substance with abuse potential but not subjected to international controls such as alcohol, khat, tobacco, and volatile substances. Social drug utilization has a negative impact on health and economic development of an individual and a c...

  4. The relationship between type of drug therapy and blood glucose self-monitoring test strips claimed by beneficiaries of the Seniors' Pharmacare Program in Nova Scotia, Canada

    Directory of Open Access Journals (Sweden)

    Sketris Ingrid

    2008-05-01

    Full Text Available Abstract Background The healthcare expenditure on self-monitoring of blood glucose (SMBG test strips under the Nova Scotia Seniors' Pharmacare Program (NSSPP has increased significantly in recent years. The objective of this study was to identify the frequency and cost of claims for blood glucose monitoring test strips by NSSPP beneficiaries in the fiscal year 2005/06 and to explore the variation in the use of test strips by type of treatment, age and sex. Methods Retrospective analysis was conducted using pharmacy administrative claims data for NSSPP beneficiaries. Study subjects were aged ≥ 65 years on October 1, 2004, received SMBG test strips in the 110 days prior to April 1, 2005, and were alive throughout the twelve month study period. Subjects were categorized into four groups: insulin only, oral antihyperglycemic agents (OAA only, both OAA and insulin; and no reimbursed diabetes medications. Statistical analysis was performed to identify differences in expenditure by medication group and in frequency of SMBG test strips claimed by medication group, age, and sex. Results Of 13,564 included beneficiaries, 13.2% were categorized as insulin only, 53.5% OAA only, 7.2% both OAA and insulin, and 26.0% no reimbursed diabetes medications. Over half (58.7% were femle. The insulin only category had the highest mean (± SD number of SMBG test strips claimed per day (2.0 ± 1.5 with a mean annual total cost of $615 ± $441/beneficiary. Beneficiaries aged 80 years and above claimed fewer test strips than beneficiaries below 80 years. Conclusion This population based study shows that in Nova Scotia the SMBG test strips claimed by the majority of seniors were within Canadian guidelines. However, a small proportion of beneficiaries claimed for SMBG test strips infrequently or too frequently, which suggests areas for improvement. The provincial drug plan covers the majority of the costs of test strip utilization, suggesting that the majority of test

  5. Fusion Canada issue 13

    International Nuclear Information System (INIS)

    A short bulletin from the National Fusion Program. Included in this issue is a report on Canada's plans to participate in the Engineering Design Activities (EDA), bilateral meetings with Canada and the U.S., committee meeting with Canada-Europe, an update at Tokamak de Varennes on Plasma Biasing experiments and boronized graphite tests, fusion materials research at the University of Toronto using a dual beam accelerator and a review of the CFFTP and the CCFM. 2 figs

  6. Canada; Selected Issues

    OpenAIRE

    International Monetary Fund

    2000-01-01

    The issue of productivity growth in Canada has received considerable attention reflecting its marked slowdown since the early 1970s and concerns about its implications for Canadian competitiveness. To better understand productivity developments in Canada, it is useful to decompose total factor productivity (TFP) into investment-specific productivity change (ISP) and technologically neutral productivity change (TNP). The gap in manufacturing productivity growth between Canada and the United St...

  7. Routine outcome measures in Canada.

    Science.gov (United States)

    Kisely, Steve; Adair, Carol E; Lin, Elizabeth; Marriott, Brian

    2015-01-01

    Canada is a federal country of 10 provinces and three territories. High level information on mental health conditions and service use has mostly been generated from administrative data collected by provinces and territories. These include four major types - hospital admissions and discharges, physician billings, ambulatory care services, and drug databases. At the national level, the Canadian Institute for Health Information brings together this information to produce indicators of outcome. Although these data provide information on patient and health system characteristics, they do not capture the full spectrum of formal and informal mental healthcare. These include changes in health status, functioning, community integration and quality of life. As a result, some jurisdictions have begun to implement more standardized measures of outcome such as the clinician-rated Health of the Nation Outcome Scales or the inpatient Resident Assessment Instrument - Mental Health. In this paper we provide an overview of mental-health-related data sources in Canada, highlight some of the more progressive practices beginning to emerge, and conclude with some thoughts about how the routine measurement and reporting of mental health outcomes in Canada might be advanced including efforts at engaging both clinicians and decision-makers. PMID:25738745

  8. Climate change and malaria in Canada: a systems approach.

    Science.gov (United States)

    Berrang-Ford, L; Maclean, J D; Gyorkos, Theresa W; Ford, J D; Ogden, N H

    2009-01-01

    This article examines the potential for changes in imported and autochthonous malaria incidence in Canada as a consequence of climate change. Drawing on a systems framework, we qualitatively characterize and assess the potential direct and indirect impact of climate change on malaria in Canada within the context of other concurrent ecological and social trends. Competent malaria vectors currently exist in southern Canada, including within this range several major urban centres, and conditions here have historically supported endemic malaria transmission. Climate change will increase the occurrence of temperature conditions suitable for malaria transmission in Canada, which, combined with trends in international travel, immigration, drug resistance, and inexperience in both clinical and laboratory diagnosis, may increase malaria incidence in Canada and permit sporadic autochthonous cases. This conclusion challenges the general assumption of negligible malaria risk in Canada with climate change. PMID:19277107

  9. Climate Change and Malaria in Canada: A Systems Approach

    Directory of Open Access Journals (Sweden)

    N. H. Ogden

    2009-01-01

    Full Text Available This article examines the potential for changes in imported and autochthonous malaria incidence in Canada as a consequence of climate change. Drawing on a systems framework, we qualitatively characterize and assess the potential direct and indirect impact of climate change on malaria in Canada within the context of other concurrent ecological and social trends. Competent malaria vectors currently exist in southern Canada, including within this range several major urban centres, and conditions here have historically supported endemic malaria transmission. Climate change will increase the occurrence of temperature conditions suitable for malaria transmission in Canada, which, combined with trends in international travel, immigration, drug resistance, and inexperience in both clinical and laboratory diagnosis, may increase malaria incidence in Canada and permit sporadic autochthonous cases. This conclusion challenges the general assumption of negligible malaria risk in Canada with climate change.

  10. Small animal dentistry in Canada: 1994 survey.

    OpenAIRE

    Haws, I J; Anthony, J .M.

    1996-01-01

    Small animal dentistry is a rapidly growing area of interest and specialization internationally, offering tremendous benefits to patients, clients, and practitioners. To date, no studies have been done to determine the standard of small animal dental care in Canada. A national mail survey was designed to document the prevalence of dental disease in small animal patients, the types of veterinary dental procedures being provided by practitioners, as well as home care recommendations and complia...

  11. Drug testing in the Australian workplace: overview of the issues.

    Science.gov (United States)

    Blaze-Temple, D

    1992-01-01

    This paper is an overview of the issues surrounding employee drug testing programs as they apply to the Australian workplace. Drug testing may be seen within a historical context of control over workers. Its practice is most prevalent in the USA, but it is also occurring in Australia, Canada and England. It is undeniable that alcohol and other drug use causes significant problems in many workplaces, though the apparently substantial costs to industry and the prevalence of drug use among workers are difficult to estimate with any degree of precision. Drug testing programs in the workplace appear to have majority public support in the USA and are even supported by some unions in Australia and the USA; there are, however, critics of the programs. The evaluation evidence to date is sparse, but is promising in that it suggests that drug testing programs can be responsible for reducing the prevalence of drug use among workers as well as dramatically reducing company costs for absenteeism, accidents and medical insurance claims. However, due to methodological shortcomings one cannot state conclusively that drug testing programs are as effective as they appear to be. Research using more rigorous designs and generating data that can be compared across studies is needed. Distasteful though drug testing is, we may see benefits in its use, similar in concept to random breath testing on our roads. Many of the procedural and legal problems in early US programs have been eliminated, refinements which should assist Australians. The legal issues, however, are quite different in Australia. A drug testing program should not be the sole remedy for reducing alcohol and other drug problems in the workplace and such a program must also be accompanied by rehabilitation and educational components. Ethical issues are briefly discussed. PMID:16840069

  12. Fusion Canada issue 14

    International Nuclear Information System (INIS)

    A short bulletin from the National Fusion Program. Included in this issue is a report on a fusion cooperation agreement between Japan and Canada, an update at Tokamak de Varennes on plasma biasing experiments and boronization tests and a collaboration between Canada and the U.S. on a compact toroid fuelling gun. 4 figs

  13. Fusion Canada issue 21

    International Nuclear Information System (INIS)

    A short bulletin from the National Fusion Program highlighting in this issue Europe proposes Canada's participation in ITER, tritium for JET, CCFM/TdeV-Tokamak helium pumping and TdeV update, ITER-related R and D at CFFTP, ITER Deputy Director visits Canada, NFP Director to Chair IFRC, Award for Akira Hirose. 3 figs

  14. Energy in Canada

    International Nuclear Information System (INIS)

    This discussion paper was prepared by the Department of Energy, Mines and Resources Canada to provide information about Canada's resource potential, the contribution of energy to the Canadian economy, Canada's place in the world energy market, and the outlook for the development of Canadian energy resources. In addition, it provides background information on issues such as: energy and the environment, energy security, Canadian ownership of energy resources, energy R and D, and energy conservation. Finally, it concludes with an indication of some of the key challenges facing the energy sector. The paper is intended to inform the public and to serve as a reference document for those participating in the review of Canada's energy options. The paper was prepared before Canada and the U.S. agreed in principle on a free trade agreement (FTA) and does not include a discussion of the FTA or its potential impacts on the energy sector

  15. 关注临床耐多药结核病的流行及治疗%Pay close attention to prevalence and treatment of multi-drug-resistant tuberculosis

    Institute of Scientific and Technical Information of China (English)

    陈红兵; 俞珊; 李净

    2011-01-01

    Multi-drug-resistant tuberculosis (MDR-TB) and extensive-drug-resistant tuberculosis (XDR-TB) has become more prevalent worldwide. It is a disease which is difficult and expensive t0 treatment, with poor prognosis and high mortality. The spread of HIV accelerated the progression of malignancy of infection of tuberculosis. The evolution of MDR- and XDR- Mycobacterium tuberculosis had been a complicated and dynamic process related to the drug-resistant genes and phenotypes. The new diagnostic and therapeutic methods, research on vaccines, and the research and application of new drugs would be conducive to inhibit the prevalence of MDR-TB and XDR-TB. Prevention of initial drug-resistance infection should be emphasized in the prevention of drug-resistant TB.%耐多药肺结核(MDR-TB)和广泛耐药肺结核(XDR-TB)在世界范围内日益增多,治疗难度大,周期长,费用高,预后差.HIV的流行更加快了患者从感染结核菌到肺结核发病的进程,病死率很高.耐多药及广泛耐药结核菌株的进化是个复杂的动态过程,可能与基因和耐药表型有关.遏制MDR-TB和XDR-TB的措施在于新的诊断方法的发展,疫苗研制以及抗结核新药的发现与应用等.加强基础结核控制以防止初治耐药是耐药结核管理的重中之重.

  16. Prevalence of HIV-1 Subtypes and Drug Resistance-Associated Mutations in HIV-1-Positive Treatment-Naive Pregnant Women in Pointe Noire, Republic of the Congo (Kento-Mwana Project).

    Science.gov (United States)

    Bruzzone, Bianca; Saladini, Francesco; Sticchi, Laura; Mayinda Mboungou, Franc A; Barresi, Renata; Caligiuri, Patrizia; Calzi, Anna; Zazzi, Maurizio; Icardi, Giancarlo; Viscoli, Claudio; Bisio, Francesca

    2015-08-01

    The Kento-Mwana project was carried out in Pointe Noire, Republic of the Congo, to prevent mother-to-child HIV-1 transmission. To determine the prevalence of different subtypes and transmitted drug resistance-associated mutations, 95 plasma samples were collected at baseline from HIV-1-positive naive pregnant women enrolled in the project during the years 2005-2008. Full protease and partial reverse transcriptase sequencing was performed and 68/95 (71.6%) samples were successfully sequenced. Major mutations to nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and protease inhibitors were detected in 4/68 (5.9%), 3/68 (4.4%), and 2/68 (2.9%) samples, respectively. Phylogenetic analysis of HIV-1 isolates showed a high prevalence of unique recombinant forms (24/68, 35%), followed by CRF45_cpx (7/68, 10.3%) and subsubtype A3 and subtype G (6/68 each, 8.8%). Although the prevalence of transmitted drug resistance mutations appears to be currently limited, baseline HIV-1 genotyping is highly advisable in conjunction with antiretroviral therapy scale-up in resource-limited settings to optimize treatment and prevent perinatal transmission. PMID:25970260

  17. Canada's nuclear export policy

    International Nuclear Information System (INIS)

    The factors influencing the evolution of Canada's nuclear export policy are examined. Initially, nuclear technology was exported to establish an industry in Canada and to share the technology with other countries. After 1974 an increasingly broad range of political and social factors were taken into account and safeguards became the dominant factor. The indirect impacts of the new policy fall into two groups. One consists of the effects of Canada's leadership in taking a tough stand on safeguards. The second group of effects involve the concern of other countries about access to secure energy supplies and advanced technology. (O.T.)

  18. HIV prevalence and cellular immune function analysis among drug addicts in certain area%某地区吸毒者HIV感染状况调查及细胞免疫功能分析

    Institute of Scientific and Technical Information of China (English)

    张丽; 曾汝良

    2012-01-01

    Objective To investigate the prevalence of human immunodeficiency virus(HIV) and immune function among drug addicts in this area. Methods 4 827 cases of drug addicts were surveyed, and detected for anti-HIV antibody and subgroups of T lymphocyte. Results The positive rate of anti-HIV antibody was 1. 28% (62/4 827). Most HIV-positive drug addicts were from other regions[75. 81% (47/62)] , injection drug users[80. 65% (50/62)] , with a history of drug abuse for more than three to five years and at the age of nineteen to less than thirty-five years old. The amount of CD3 +CD4+ T lymphocyte and ratio of CD4+/ CD8+ were both lower than healthy subjects(P5~10)年[67.74%(42/62)]、年龄范围为(19~<35)岁[69.35%(43/62)].HIV阳性者CD3+CD4+T淋巴细胞数及CD4+/CD8+比值均低于健康者(P<0.05).结论 该地区HIV感染吸毒者存在低龄化和地域外来化趋势,需加强相关管理措施,重视健康教育.

  19. Canada's Neutron Beam Laboratory

    International Nuclear Information System (INIS)

    This paper describes the current and planned activities of Canada's Neutron Beam Laboratory which is managed by the National Research Council of Canada. In 1994, Professor Bertram Brockhouse shared the Nobel Prize in Physics for his pioneering work carried out in this laboratory. He developed neutron scattering as a powerful and versatile tool for investigating materials at the level of molecules and nano structures. The neutron source for this work is Canada's NRU reactor located at the Chalk River Nuclear Laboratories of the Atomic Energy of Canada Limited. This neutron source is also used for the production of medical isotopes, testing of components for the nuclear power stations and neutron scattering experiments on materials

  20. Physics Teaching in Canada.

    Science.gov (United States)

    McFarland, Ernie; Hirsch, Alan

    1992-01-01

    Provides an overview of physics teaching in Canada. Responds to questions involving the curriculum, efforts to promote gender equity, teaching methods, high school physics teachers, physics teaching organizations, and educational trends. (27 references) (MDH)

  1. Fusion Canada issue 20

    International Nuclear Information System (INIS)

    Fusion Canada's publication of the National Fusion Program. Included in this issue is the CFFTP Industrial Impact Study, CCFM/TdeV Update:helium pumping, research funds, and deuterium in beryllium - high temperature behaviour. 3 figs

  2. Uranium in Canada

    International Nuclear Information System (INIS)

    In 1974 the Minister of Energy, Mines and Resources (EMR) established a Uranium Resource Appraisal Group (URAG) within EMR to audit annually Canada's uranium resources for the purpose of implementing the federal government's uranium export policy. A major objective of this policy was to ensure that Canadian uranium supplies would be sufficient to meet the needs of Canada's nuclear power program. As projections of installed nuclear power growth in Canada over the long term have been successively revised downwards (the concern about domestic security of supply is less relevant now than it was 10 years ago) and as Canadian uranium supply capabilities have expanded significantly. Canada has maintained its status as the western world's leading exporter of uranium and has become the world's leading producer. Domestic uranium resource estimates have increased to 551 000 tonnes U recoverable from mineable ore since URAG completed its last formal assessment (1982). In 1984, Canada's five primary uranium producers employed some 5800 people at their mining and milling operations, and produced concentrates containing some 11 170 tU. It is evident from URAG's 1984 assessment that Canada's known uranium resources, recoverable at uranium prices of $150/kg U or less, are more than sufficient to meet the 30-year fuelling requirements of those reactors that are either in opertaion now or committed or expected to be in-service by 1995. A substantial portion of Canada's identified uranium resources, recoverable within the same price range, is thus surplus to Canadian needs and available for export. Sales worth close to $1 billion annually are assured. Uranium exploration expenditures in Canada in 1983 and 1984 were an estimated $41 million and $35 million, respectively, down markedly from the $128 million reported for 1980. Exploration drilling and surface development drilling in 1983 and 1984 were reported to be 153 000 m and 197 000 m, respectively, some 85% of which was in

  3. Canada; Selected Issues

    OpenAIRE

    International Monetary Fund

    1998-01-01

    This Selected Issues paper reviews the factors that may explain high and persistent unemployment in Canada, with particular emphasis on the role that a decline in the relative cost of capital may have had on trend unemployment. The analysis suggests that in Canada a declining trend in the cost of capital, associated with technological changes and innovations, has been an important factor in explaining the rise and persistence of unemployment. The paper also analyzes recent trends in personal ...

  4. Child Poverty in Canada

    OpenAIRE

    Thomas Crossley; Lori Curtis

    2003-01-01

    A 1989 all-party motion of parliament called for the elimination of child poverty in Canada by the year 2000. Despite a series of policy initiatives, recent reports suggest that the child poverty rate may now be comparable to that in 1989. The apparent persistence of child poverty in Canada might reflect socioeconomic developments, or something about the way that child poverty is measured. Using micro data covering the period 1986 to 2000 we find little support for these explanations.

  5. Canada's radiation scandal?

    International Nuclear Information System (INIS)

    In July 1990, Greenpeace distributed a 16-page treatise entitled 'Canada's Radiation Scandal' to a wide audience. The bottom line of the Greenpeace critique was that 'Canada's radiation limits are among the worst in the developed world'. This is a commentary on the Greenpeace pamphlet from the Atomic Energy Control Board (AECB), the body that sets and enforces radiation standards covering the use of nuclear energy in Canadian industry, science and medicine

  6. Trends in Hepatitis B Virus, Hepatitis C Virus, and Human Immunodeficiency Virus Prevalence, Risk Behaviors, and Preventive Measures among Seattle Injection Drug Users Aged 18–30 Years, 1994–2004

    OpenAIRE

    Burt, Richard D.; Hagan, Holly; Garfein, Richard S.; Sabin, Keith; Weinbaum, Cindy; Thiede, Hanne

    2007-01-01

    Injection drug users (IDUs) are at risk for infection with hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV). Information on time trends in prevalence of these viruses among IDUs and in behaviors influencing their transmission can help define the status of these epidemics and of public health efforts to control them. We conducted a secondary data analysis combining cross-sectional data from IDUs aged 18–30 years enrolled in four Seattle-area studies from...

  7. South Asian populations in Canada: migration and mental health

    OpenAIRE

    Islam, Farah; Khanlou, Nazilla; Tamim, Hala

    2014-01-01

    Background South Asian populations are the largest visible minority group in Canada; however, there is very little information on the mental health of these populations. The objective of this study was to determine the prevalence rates and characteristics of mental health outcomes for South Asian first-generation immigrant and second-generation Canadian-born populations. Methods The Canadian Community Health Survey (CCHS) 2011 was used to calculate the estimated prevalence rates of the follow...

  8. Calendar time trends in the incidence and prevalence of triple-class virologic failure in antiretroviral drug-experienced people with HIV in Europe

    DEFF Research Database (Denmark)

    Nakagawa, Fumiyo; Lodwick, Rebecca; Costagliola, Dominique;

    2012-01-01

    Despite the increasing success of antiretroviral therapy (ART), virologic failure of the 3 original classes [triple-class virologic failure, (TCVF)] still develops in a small minority of patients who started therapy in the triple combination ART era. Trends in the incidence and prevalence of TCVF...

  9. 英国、加拿大和澳大利亚国家卫生服务保障体系下罕用药遴选原则分析%Selection Principle of Orphan Drug Under UK, Canada and Australia National Health Service Security System

    Institute of Scientific and Technical Information of China (English)

    胡娟娟; 陈昕; 龚时薇

    2016-01-01

    采用对比研究方法,分析英国、加拿大和澳大利亚医疗保险制度中罕用药保险覆盖遴选的评价原则. 研究发现3个国家医保药物评价机构罕用药遴选的评价原则不仅考虑药物的经济学及循证医学评价证据,而且还引入新的评价理念,如风险分担、社会团结,利益相关者参与等. 建议我国罕用药遴选评价,不仅要考虑罕用药的成本,更要综合考虑罕用药的治疗价值、唯一性和社会需要.%This paper used comparative method to analyze the evaluation principles of the selection of orphan drug of medical insurance sys-tem in UK, Canada and Australia.The medical insurance system of UK, Canada and Australia not only focuses on the economic and evidence-based evaluation principles of orphan drugs, but also considers some new ideas during the evaluation process of orphan drugs, such as risk-sha-ring agreement, social solidarity, stakeholder participation, and so on.Based on the good experiences from three medical insurance systems, it is very crucial for the evaluation principles of orphan drugs'selection that we should consider the cost of orphan drugs and also care for the treatment value and therapeutic uniqueness and society needs of the orphan drugs in China.

  10. The prevalence and relative risk of drink and drug driving in the Netherlands: a case-control study in the Tilburg police district : research in the framework of the European research programme IMMORTAL (Impaired Motorists, Methods of Roadside Testing and Assessment for Licensing).

    NARCIS (Netherlands)

    Mathijssen, M.P.M. & Houwing, S.

    2005-01-01

    Drink and drug driving can have an impact on the driving performance and accident risk. This epidemiological study, which forms part of the European project IMMORTAL, investigates the prevalence of eight defined drug groups, including alcohol, among drivers in the Tilburg police district. To examine

  11. Transfusion and risk of infection in Canada: Update 2006

    OpenAIRE

    2006-01-01

    In Canada and other developed countries, many steps are taken to minimize the risk of infection from transfusion of blood or blood products (1). However, the infection risk can never be zero because these are biological products taken from living donors who are never 'germ free' (2). This is in contrast to drugs that can be manufactured de novo under sterile conditions in a laboratory. The present note provides an update on transfusion infection risks in Canada. It replaces the 2005 note (3) ...

  12. Sustained reduction in prevalence of lymphatic filariasis infection in spite of missed rounds of mass drug administration in an area under mosquito nets for malaria control

    OpenAIRE

    Shimada Masaaki; Omar Anisa A; Mukoko Dunstan A; Wamae C Njeri; Mwandawiro Charles S; Njenga Sammy M; Bockarie Moses J; Molyneux David H

    2011-01-01

    Abstract Background The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was established by the World Health Organisation (WHO) in 2000 with the goal of eliminating lymphatic filariasis (LF) as a public health problem globally by 2020. Mass drug administration (MDA) of antifilarial drugs is the principal strategy recommended for global elimination. Kenya launched a National Programme for Elimination of Lymphatic Filariasis (NPELF) in Coast Region in 2002. During the same year a long...

  13. Constructing Bullying in Ontario, Canada: A Critical Policy Analysis

    Science.gov (United States)

    Winton, Sue; Tuters, Stephanie

    2015-01-01

    As the prevalence and negative effects of bullying become widely known, people around the world seem desperate to solve the bullying "problem". A sizeable body of research about many aspects of bullying and a plethora of anti-bullying programmes and policies now exist. This critical policy analysis asks: how does Ontario, Canada's…

  14. Alzheimer's disease and other dementias in Canada.

    Science.gov (United States)

    Wong, Suzy L; Gilmour, Heather; Ramage-Morin, Pamela L

    2016-05-18

    This article provides information on Alzheimer's disease and other dementias, using the 2010/2011 Canadian Community Health Survey, the 2011/2012 Survey of Neurological Conditions in Institutions in Canada, and the 2011 Survey on Living with Neurological Conditions in Canada. Among Canadians aged 45 or older, an estimated 0.8% in private households and 45% in long-term residential care facilities had a diagnosis of dementia. Prevalence rose with age. The vast majority of people with dementia in private households received assistance with medical care (81%), housework and home maintenance (83%), meal preparation (88%), emotional support (90%), transportation (92%), and managing care (92%). Among those receiving assistance, 85% relied, at least in part, on family, friends or neighbours. The primary caregiver tended to be a spouse (46%) or an adult child (44%), most of whom were daughters (71%). The majority of primary caregivers lived in the same household (83%) and provided daily care (86%). PMID:27192206

  15. Prevalence of class1, 2 and 3 integrons among extensive drug resistance Acinetobacter baumanii strains isolated from intensive care units in Hamadan, west province, Iran

    OpenAIRE

    Fatemeh abestani, 1Mina Safari, 2Ghodratollah Roshanaii, 1Mohammad Yousef Alikhani Moammadi; Mohammad Reza Arabestani; Mina Safari; Ghodratollah Roshanaii; Mohammad Yousef Alikhani

    2014-01-01

    Background and Aim: Acinetobacter baumannii is opportunistic, gram negative, aerobic and nonfermentative coccobacilli. It is difficult to control and eradicate these bacteria, because of increased resistance to last-line antibiotic therapy and high peripheral resistance. The purpose of this study was to determine the prevalence of integron  and its relationship with the antibiotic resistance in A. baumannii. Materials and Methods: 100 isolates of A. baumannii were ...

  16. High prevalence of Streptococcus pneumoniae in adenoids and nasopharynx in preschool children with recurrent upper respiratory tract infections in Poland – distribution of serotypes and drug resistance patterns

    OpenAIRE

    Niedzielski, Artur; Korona-Glowniak, Izabela; Malm, Anna

    2013-01-01

    Background Streptococcus pneumoniae is one of the major bacterial pathogens colonizing nasopharynx, and often causes upper respiratory tract infections in children. We investigated the prevalence of S. pneumoniae in nasopharynx and adenoid core in 57 children aged 2–5 years who underwent adenoidectomy for recurrent pharyngotonsillitis, and we determined serotypes and antibiotic resistance patterns of the isolated pneumococci. Material/Methods The nasopharyngeal specimens obtained before adeno...

  17. Increases and decreases in drug use attributed to housing status among street-involved youth in a Canadian setting

    OpenAIRE

    Cheng, Tessa; Wood, Evan; Nguyen, Paul; Kerr, Thomas; DeBeck, Kora

    2014-01-01

    Background Among a cohort of drug-using street-involved youth, we sought to identify the prevalence of reporting increases and decreases in illicit drug use due to their current housing status and to identify factors associated with reporting these changes. Findings This longitudinal study was based on data collected between June 2008 and May 2012 from a prospective cohort of street-involved youth aged 14–26 in Vancouver, Canada. At semi-annual study follow-up visits, youth were aske...

  18. Injection site infections and injuries in men who inject image- and performance-enhancing drugs: prevalence, risks factors, and healthcare seeking.

    Science.gov (United States)

    Hope, V D; McVeigh, J; Marongiu, A; Evans-Brown, M; Smith, J; Kimergård, A; Parry, J V; Ncube, F

    2015-01-01

    People who inject drugs are vulnerable to infections and injuries at injection sites, but these have rarely been studied in those injecting image- and performance-enhancing drugs (IPEDs). This study examined the factors associated with reported symptoms of injection site infections and injuries in IPED injectors. Of the 366 male IPED injectors surveyed, 42% reported ever having redness, swelling and tenderness (36% in the preceding year), and 6·8% had ever had an abscess or open wound at an injection site. Having these symptoms was associated with a range of factors related to drug use and healthcare utilization. One sixth (17%) of those reporting redness, tenderness and swelling had ever sought treatment, as had the majority (76%) of those reporting an abscess, sore or open wound. Most common sources of advice were emergency clinics and General Practitioners. Interventions are needed to support access to appropriate injecting equipment and provide targeted harm reduction advice. PMID:24713416

  19. Hunger among Inuit children in Canada

    Directory of Open Access Journals (Sweden)

    Leanne C. Findlay

    2013-04-01

    Full Text Available Background and objectives. Inuit populations may be at increased risk for experiencing poor nutrition or hunger due to limited access and availability to food. The prevalence and correlates of parental perceptions of hunger among a nationally representative sample of Inuit children in Canada have not yet been reported. Design. Data are from the 2006 Aboriginal Children's Survey (ACS. Sociodemographic information, dietary behaviours and hunger status were parent-reported via a household interview for Inuit children aged 2–5 years (n=1,234. Prevalence of hunger was calculated among Inuit children by sociodemographic factors and by dietary behaviours. In addition, a multivariate logistic regression model was conducted to determine factors associated with parental perception of ever experiencing hunger. Results. The prevalence of Inuit children in Canada aged 2–5 years ever experiencing hunger was 24.4%. Children who were reported to have experienced hunger consumed milk and milk products (p<0.001; fish, eggs and meat (p<0.05; fruits (p<0.001; and vegetables (p<0.001 significantly less often than never-hungry children. Fast food and processed foods, soft drinks and juice, and salty snacks, sweets and desserts were consumed as often as never-hungry children (all p>0.05. The majority (81% of Inuit parents/guardians of ever-hungry children sought help from family or friends. Factors associated with an increased likelihood of experiencing hunger include sociodemographic characteristics (such as income and household size, living in an Inuit region and living in a community with cultural activities. Conclusion. About 1 in 4 Inuit children were reported by their parents to have experienced hunger, and hunger was associated with region, sociodemographic and community factors. Future research could further examine the impact of ever experiencing hunger on the health status of Inuit children and their families in Canada.

  20. A review of feline leukemia virus and feline immunodeficiency virus seroprevalence in cats in Canada.

    Science.gov (United States)

    Little, Susan

    2011-10-15

    Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are common and important infectious diseases of cats in Canada. Prevalence data are necessary to define prophylactic, management, and therapeutic measures for stray, feral and owned cats. Recently, comprehensive data on the seroprevalence of retrovirus infections of cats in Canada have become available and are reviewed. Further investigation into geographic variations in retrovirus seroprevalence within Canada is warranted, and may provide information to improve recommendations for testing and prevention. As well, more information is needed on FIV subtypes in Canada to improve diagnostics and vaccines, as well as to provide information on disease outcomes. PMID:21757241

  1. The prevalence of the pre-existing hepatitis C viral variants and the evolution of drug resistance in patients treated with the NS3-4a serine protease inhibitor telaprevir

    Energy Technology Data Exchange (ETDEWEB)

    Rong, Libin [Los Alamos National Laboratory; Ribeiro, Ruy M [Los Alamos National Laboratory; Perelson, Alan S [Los Alamos National Laboratory

    2008-01-01

    Telaprevir (VX-950), a novel hepatitis C virus (HCV) NS3-4A serine protease inhibitor, has demonstrated substantial antiviral activity in patients infected with HCV genotype 1. Some patients experience viral breakthrough, which has been shown to be associated with emergence of telaprevir-resistant HCV variants during treatment. The exact mechanisms underlying the rapid selection of drug resistant viral variants during dosing are not fully understood. In this paper, we develop a two-strain model to study the pre-treatment prevalence of the mutant virus and derive an analytical solution of the mutant frequency after administration of the protease inhibitor. Our analysis suggests that the rapid increase of the mutant frequency during therapy is not due to mutant growth but rather due to the rapid and profound loss of wild-type virus, which uncovers the pre-existing mutant variants. We examine the effects of backward mutation and hepatocyte proliferation on the pre-existence of the mutant virus and the competition between wild-type and drug resistant virus during therapy. We then extend the simple model to a general model with multiple viral strains. Mutations during therapy do not play a significant role in the dynamics of various viral strains, although they are capable of generating low levels of HCV variants that would otherwise be completely suppressed because of fitness disadvantages. Hepatocyte proliferation may not affect the pretreatment frequency of mutant variants, but is able to influence the quasispecies dynamics during therapy. It is the relative fitness of each mutant strain compared with wild-type that determines which strain(s) will dominate the virus population. The study provides a theoretical framework for exploring the prevalence of pre-existing mutant variants and the evolution of drug resistance during treatment with other protease inhibitors or HCV polymerase inhibitors.

  2. Prevalence of lymphatic filariasis in a tea garden worker population of Dibrugarh (Assam, India after six rounds of mass drug administration

    Directory of Open Access Journals (Sweden)

    A M Khan

    2015-01-01

    Interpretation & conclusion: Mass drug administration data showed six rounds of MDA with drug distribution coverage in between 63.42 and 95.93% in the study population. Out of 634 individuals examined 47 were found microfilaraemic giving an overall infection rate of 7.41%. Mosquito vector infection and infectivity rates were 13.20 and 3.70%, respectively. Presence of high mf rate, vector infectivity rate and clinical cases in the study population after six rounds of MDA warrants concerted efforts to be made for effective implementation and monitoring of MDA for success of LF elimination programme.

  3. Illicit drugs in Canadian municipal wastewater and estimates of community drug use

    International Nuclear Information System (INIS)

    In this study of wastewater treatment plants in three Canadian cities, selected illicit drugs, including cocaine and its major metabolite, benzoylecgonine (BE), amphetamine, methamphetamine and ecstasy (i.e. MDMA) were detected in untreated wastewater. Cocaine was the most widely used illicit drug at a median level for the 3 cities of 15.7 doses per day per 1000 people. For the other drugs, the median doses per day per 1000 people were 1.8 for amphetamine, 4.5 for methamphetamine and 0.4 for ecstasy. Methamphetamine use was highest in the largest city and cocaine use was lowest in the smallest city. Removal of the illicit drugs by wastewater treatment was generally >50%, except in a WWTP that uses primary treatment. The community consumption estimate for ecstasy in the present study is far below published estimates of the prevalence of ecstasy use among the Canadian population, which may be due to only occasional use of ecstasy. - Cocaine and amphetamines were detected in untreated and treated sewage in the wastewater treatment plants of three Canadian cities, and community consumption patterns estimated from the concentrations of the drugs in untreated wastewater were consistent with estimates of the use of illicit drugs in Canada.

  4. Illicit drugs in Canadian municipal wastewater and estimates of community drug use

    Energy Technology Data Exchange (ETDEWEB)

    Metcalfe, Chris, E-mail: cmetcalfe@trentu.c [Worsfold Water Quality Centre, Trent University, 1600 West Bank Drive Peterborough, ON, K9J 7B8 (Canada); Tindale, Kathryn [Worsfold Water Quality Centre, Trent University, 1600 West Bank Drive Peterborough, ON, K9J 7B8 (Canada); Li, Hongxia, E-mail: lihongxia@trentu.c [Worsfold Water Quality Centre, Trent University, 1600 West Bank Drive Peterborough, ON, K9J 7B8 (Canada); Rodayan, Angela [Department of Chemical Engineering, McGill University, 3610 University St., Montreal, QC, H3A 2B2 (Canada); Yargeau, Viviane, E-mail: viviane.yargeau@mcgill.c [Department of Chemical Engineering, McGill University, 3610 University St., Montreal, QC, H3A 2B2 (Canada)

    2010-10-15

    In this study of wastewater treatment plants in three Canadian cities, selected illicit drugs, including cocaine and its major metabolite, benzoylecgonine (BE), amphetamine, methamphetamine and ecstasy (i.e. MDMA) were detected in untreated wastewater. Cocaine was the most widely used illicit drug at a median level for the 3 cities of 15.7 doses per day per 1000 people. For the other drugs, the median doses per day per 1000 people were 1.8 for amphetamine, 4.5 for methamphetamine and 0.4 for ecstasy. Methamphetamine use was highest in the largest city and cocaine use was lowest in the smallest city. Removal of the illicit drugs by wastewater treatment was generally >50%, except in a WWTP that uses primary treatment. The community consumption estimate for ecstasy in the present study is far below published estimates of the prevalence of ecstasy use among the Canadian population, which may be due to only occasional use of ecstasy. - Cocaine and amphetamines were detected in untreated and treated sewage in the wastewater treatment plants of three Canadian cities, and community consumption patterns estimated from the concentrations of the drugs in untreated wastewater were consistent with estimates of the use of illicit drugs in Canada.

  5. The Prevalence and Comorbidity between Delinquency, Drug Abuse, Suicide Attempts, Physical and Sexual Abuse, and Self-Mutilation among Delinquent Hispanic Females

    Science.gov (United States)

    Cuellar, Jeanette; Curry, Theodore R.

    2007-01-01

    Representative data show that drug abuse, delinquency, and suicide attempts are major concerns among adolescent Hispanic females. Although comorbidity research indicates that such problems tend to be related to each other, this research largely neglects Hispanic females. Using data from presentence investigations on 141 Hispanic girls sentenced to…

  6. Sylvatic trichinosis in Canada.

    OpenAIRE

    Smith, H J; Snowdon, K E

    1988-01-01

    Pepsin digestion of musculature from 2253 animals revealed that sylvatic trichinosis occurred in various species of mammals from the eastern to the western Arctic and extended down into the Rocky Mountain and Foothills regions of western Canada. Infections were demonstrated in Arctic fox, red fox, wolf, raccoon, coyote, lynx, bobcat and dog.

  7. Update on Canada.

    Science.gov (United States)

    Hochstadt, John Webster

    1994-01-01

    Gift planning is increasing in Canada's colleges and universities to offset effects of retrenchment. New annuity vehicles and the emergence of university Crown Foundations offer tax breaks that support private giving to institutions. In addition, a simplified process for gifts is anticipated. (MSE)

  8. Nuclear power in Canada

    International Nuclear Information System (INIS)

    The Canadian Nuclear Association believes that the CANDU nuclear power generation system can play a major role in achieving energy self-sufficiency in Canada. The benefits of nuclear power, factors affecting projections of electric power demand, risks and benefits relative to other conventional and non-conventional energy sources, power economics, and uranium supply are discussed from a Canadian perspective. (LL)

  9. Fusion Canada issue 7

    International Nuclear Information System (INIS)

    A short bulletin from the National Fusion Program. Included in this issue are CFFTP highlights on the Karlsruhe Isotope Separation System, a report on ITER tritium process systems, an experimental update on Tokamak de Varennes and Canada-U.S. bilateral technical collaboration topics. 2 figs

  10. Nuclear technology in Canada

    International Nuclear Information System (INIS)

    This pamphlet provides a summary of the research being carried out by Atomic Energy of Canada Limited. The design and development of the CANDU type reactor are highlighted and the contribution of nuclear technology to medicine, agriculture and the Canadian economy is briefly discussed

  11. Fusion Canada issue 22

    International Nuclear Information System (INIS)

    A short bulletin from the National Fusion Program highlighting in this issue a bi-lateral meeting between Canada and Japan, water and hydrogen detritiation, in-situ tokamak surface analysis, an update of CCFM/TdeV and tritium accounting Industry guidance in Fusion, fast probe for plasma-surface interaction. 4 figs

  12. Fusion Canada issue 17

    International Nuclear Information System (INIS)

    A short bulletin from the National Fusion Program. Included in this issue is a report on increased funding for the Canadian Fusion Program, news of the compact Toroid fuelling gun, an update on Tokamak de Varennes, the Canada - U.S. fusion meeting, measurements of plasma flow velocity, and replaceable Tokamak divertors. 4 figs

  13. Electric power in Canada 1992

    International Nuclear Information System (INIS)

    Electric power in Canada is given a comprehensive review by the Electricity Branch of the Department of Natural Resources Canada. The Electric Power Industry is scrutinized for electricity consumption, generation, trade and pricing across all of Canada. 98 tabs. 26 figs

  14. Uranium in Canada

    International Nuclear Information System (INIS)

    In 1988 Canada's five uranium producers reported output of concentrate containing a record 12,470 metric tons of uranium (tU), or about one third of total Western world production. Shipments exceeded 13,200 tU, valued at $Cdn 1.1 billion. Most of Canada's uranium output is available for export for peaceful purposes, as domestic requirements represent about 15 percent of production. The six uranium marketers signed new sales contracts for over 11,000 tU, mostly destined for the United States. Annual exports peaked in 1987 at 12,790 tU, falling back to 10,430 tU in 1988. Forward domestic and export contract commitments were more than 70,000 tU and 60,000 tU, respectively, as of early 1989. The uranium industry in Canada was restructured and consolidated by merger and acquisition, including the formation of Cameco. Three uranium projects were also advanced. The Athabasca Basin is the primary target for the discovery of high-grade low-cost uranium deposits. Discovery of new reserves in 1987 and 1988 did not fully replace the record output over the two-year period. The estimate of overall resources as of January 1989 was down by 4 percent from January 1987 to a total (measured, indicated and inferred) of 544,000 tU. Exploration expenditures reached $Cdn 37 million in 1987 and $59 million in 1988, due largely to the test mining programs at the Cigar Lake and Midwest projects in Saskatchewan. Spot market prices fell to all-time lows from 1987 to mid-1989, and there is little sign of relief. Canadian uranium production capability could fall below 12,000 tU before the late 1990s; however, should market conditions warrant output could be increased beyond 15,000 tU. Canada's known uranium resources are more than sufficient to meet the 30-year fuel requirements of those reactors in Canada that are now or are expected to be in service by the late 1990s. There is significant potential for discovering additional uranium resources. Canada's uranium production is equivalent, in

  15. Canada country report

    Energy Technology Data Exchange (ETDEWEB)

    Cottrill, Cheryl [Bruce Power, 3394 County Road 20 - RRH2, N0G 2T0 Tiverton ON (Canada)

    2008-07-01

    1 - Nuclear 2007 highlights: New Build Applications and Environmental Assessments (Ontario Power Generation (OPG), Bruce Power, Bruce Power Alberta), Refurbishments (Bruce Power's Bruce A Units 1 and 2 Restart Project, NB Power's Refurbishment of Point Lepreau, New Brunswick, Atomic Energy of Canada Limited (AECL) NRU 50. Anniversary, expansion of the solid radioactive waste storage facilities at Gentilly-2 nuclear generating station, Ontario Power Generation (OPG) Deep Geologic Repository..); 2. Nuclear overview: a. Energy policy (Future of nuclear power, state of the projects, schedule, Refurbishment), b. Public acceptance, Statements from Government Officials in Canada; c. Nuclear equipment (number and type); d. Nuclear waste management, Deep Geologic Repository; e. Nuclear research at AECL; f. Other nuclear activities (Cameco Corporation, MDS Nordion); 3. Nuclear competencies; 4. WIN 2007 Main Achievements: GIRLS Science Club, Skills Canada, WiN-Canada Web site, Book Launch, WINFO, 2007 WiN-Canada conference 4 - Summary: - 14.6% of Canada's electricity is provided by Candu nuclear reactors; Nuclear equipment: 10 Research or isotope producing reactors - Pool-Type; Slowpoke 2; Sub-Critical assembly; NRU; and Maple; 22 Candu reactors providing electricity production - 18 of which are currently operating. Public acceptance: 41% feel nuclear should play more of a role, 67% support refurbishment, 48% support new build, 13% point gender gap in support, with men supporting more than women. Energy policy: Future of nuclear power - recognition that nuclear is part of the solution across Canada; New Build - 3 applications to regulator to prepare a site for new build, in Provinces of Ontario and Alberta, with one feasibility study underway in New Brunswick; Refurbishment - Provinces of Ontario (2010) and New Brunswick (2009). Nuclear waste management policy: Proposal submitted to regulator to prepare, construct and operate a deep geologic disposal facility

  16. Canada country report

    International Nuclear Information System (INIS)

    1 - Nuclear 2007 highlights: New Build Applications and Environmental Assessments (Ontario Power Generation (OPG), Bruce Power, Bruce Power Alberta), Refurbishments (Bruce Power's Bruce A Units 1 and 2 Restart Project, NB Power's Refurbishment of Point Lepreau, New Brunswick, Atomic Energy of Canada Limited (AECL) NRU 50. Anniversary, expansion of the solid radioactive waste storage facilities at Gentilly-2 nuclear generating station, Ontario Power Generation (OPG) Deep Geologic Repository..); 2. Nuclear overview: a. Energy policy (Future of nuclear power, state of the projects, schedule, Refurbishment), b. Public acceptance, Statements from Government Officials in Canada; c. Nuclear equipment (number and type); d. Nuclear waste management, Deep Geologic Repository; e. Nuclear research at AECL; f. Other nuclear activities (Cameco Corporation, MDS Nordion); 3. Nuclear competencies; 4. WIN 2007 Main Achievements: GIRLS Science Club, Skills Canada, WiN-Canada Web site, Book Launch, WINFO, 2007 WiN-Canada conference 4 - Summary: - 14.6% of Canada's electricity is provided by Candu nuclear reactors; Nuclear equipment: 10 Research or isotope producing reactors - Pool-Type; Slowpoke 2; Sub-Critical assembly; NRU; and Maple; 22 Candu reactors providing electricity production - 18 of which are currently operating. Public acceptance: 41% feel nuclear should play more of a role, 67% support refurbishment, 48% support new build, 13% point gender gap in support, with men supporting more than women. Energy policy: Future of nuclear power - recognition that nuclear is part of the solution across Canada; New Build - 3 applications to regulator to prepare a site for new build, in Provinces of Ontario and Alberta, with one feasibility study underway in New Brunswick; Refurbishment - Provinces of Ontario (2010) and New Brunswick (2009). Nuclear waste management policy: Proposal submitted to regulator to prepare, construct and operate a deep geologic disposal facility in Ontario

  17. Prevalence and correlates of HIV risk among adolescents and young adults reporting drug use: Data from an urban Emergency Department in the U.S

    Science.gov (United States)

    Bonar, Erin E.; Whiteside, Lauren K.; Walton, Maureen A.; Zimmerman, Marc A.; Booth, Brenda M.; Blow, Frederic C.; Cunningham, Rebecca

    2014-01-01

    Adolescents and young adults who use substances are at particularly high risk for contracting Human Immunodeficiency Virus (HIV). The Emergency Department (ED) is a critical location for HIV prevention for at-risk youth. To inform future interventions in the ED, this study identifies correlates of HIV risk behaviors among substance using youth seeking ED care. Among 600 14-24-year-olds with past 6-month drug use, bivariate correlates of HIV risk included: older age, female gender, depressive symptoms, alcohol use, marijuana use, other drug use, and dating, peer, and community violence. Regression analyses indicated that older age, marijuana use, and dating violence were positively related to HIV risk. Results suggest HIV prevention efforts for youth in the urban ED should address marijuana use and dating violence as well as sexual risk behaviors. PMID:25126024

  18. Epidemiology of myasthenia gravis in Ontario, Canada.

    Science.gov (United States)

    Breiner, Ari; Widdifield, Jessica; Katzberg, Hans D; Barnett, Carolina; Bril, Vera; Tu, Karen

    2016-01-01

    Incidence and prevalence estimates in myasthenia gravis have varied widely. Recent studies based on administrative health data have large sample sizes but lack rigorous validation of MG cases, and have not examined the North American population. Our aim was to explore trends in MG incidence and prevalence for the years 1996-2013 in the province of Ontario, Canada (population 13.5 million). We employed a previously validated algorithm to identify MG cases. Linking with census data allowed for the calculation of crude- and age/sex-standardized incidence and prevalence rates for the years 1996-2013. The regional distribution of MG cases throughout the province was examined. Mean age at the first myasthenia gravis encounter was 60.2 ± 17.1 years. In 2013, there were 3611 prevalent cases in Ontario, and the crude prevalence rate was 32.0/100,000 population. Age- and sex-standardized prevalence rates rose consistently over time from 16.3/100,000 (15.4-17.1) in 1996 to 26.3/100,000 (25.4-27.3) in 2013. Standardized incidence rates remained stable between 1996 (2.7/100,000; 95% CL 2.3-3.0) and 2013 (2.3/100,000; 2.1-2.6). Incidence was highest in younger women and older men, and geographic variation was evident throughout the province. In conclusion, this large epidemiological study shows rising myasthenia gravis prevalence with stable incidence over time, which is likely reflective of patients living longer, possibly due to improved disease treatment. Our findings provide accurate information on the Canadian epidemiology of myasthenia gravis and burden for health care resources planning for the province, respectively. PMID:26573434

  19. Impact of two rounds of mass drug administration using diethylcarbamazine combined with albendazole on the prevalence of Brugia timori and of intestinal helminths on Alor Island, Indonesia

    OpenAIRE

    Oqueka, Tim; Supali, Taniawati; Ismid, Is Suhariah; Purnomo,; Rückert, Paul; Bradley, Mark; Fischer, Peter

    2005-01-01

    Background Annual mass drug administration (MDA) using diethylcarbamizine (DEC, 6 mg/kg) combined with albendazole (alb, 400 mg) is recommended by the Global Programme to Eliminate Lymphatic Filariasis (GPELF). This strategy has been shown to be efficient in the of control bancroftian filariasis, but data on brugian filariasis as well as on the positive side effects on intestinal helminths are lacking. Methods The effect of one selective treatment and two rounds of MDA using DEC and alb on th...

  20. The Added Value of Water, Sanitation, and Hygiene Interventions to Mass Drug Administration for Reducing the Prevalence of Trachoma: A Systematic Review Examining

    OpenAIRE

    Anyess Travers; Sheryl Strasser; Palmer, Stephanie L.; Christine Stauber

    2013-01-01

    Trachoma is the leading cause of infectious blindness worldwide. The SAFE strategy, the World Health Organization-recommended method to eliminate blinding trachoma, combines developments in water, sanitation, surgery, and antibiotic treatment. Current literature does not focus on the comprehensive effect these components have on one another. The present systematic review analyzes the added benefit of water, sanitation, and hygiene education interventions to preventive mass drug administration...

  1. An association between anti-platelet drug use and reduced cancer prevalence in diabetic patients: results from the Vermont Diabetes Information System Study

    OpenAIRE

    Ramos-Nino Maria E; Holmes Chris E; Littenberg Benjamin

    2010-01-01

    Abstract Background Diabetes is associated with an increased risk of several malignancies. Both diabetic patients and patients with cancer have an increase in platelet reactivity and platelet activation has recently emerged as a potential mediator of cancer progression. Drug therapies, such as aspirin, that reduce platelet reactivity reduce both cardiovascular and cancer risk. Methods We performed a cross-sectional analysis to assess the association between history of cancer and current anti-...

  2. Prevalence of HIV, Hepatitis B and C Infections and an Assessment of HCV-Genotypes and Two IL28B SNPs among People Who Inject Drugs in Three Regions of Nepal

    Science.gov (United States)

    Kinkel, Hans-Tilmann; Karmacharya, Dibesh; Shakya, Jivan; Manandhar, Sulochana; Panthi, Santosh; Karmacharya, Prajwola; Sitaula, Deepika; Thapaliya, Reenu; K. C., Prawachan; Rai, Apurva; Dixit, Sameer

    2015-01-01

    As part of a comprehensive health care programme for people who use drugs in Nepal, HIV and viral hepatitis B and C status—including risk factors, HCV-genotypes and co-infections—as well as two IL28B Single-nucleotide polymorphisms (SNPs) were assessed for a random sample of 401 people who inject drugs in three regions of Nepal: mid-western Terrai (Nepalgunj), the eastern region (Dharan, Biratnagar) and the central region (Kathmandu, Lalitpur and Chitwan). Individuals were included who showed at least a minimum of health care seeking behaviour. This latter criterion was defined by being registered with any organisation offering health services. The average age of the participants was 30.5 yrs, and the average length of intravenous drug use was 8.5 yrs. The prevalence rates of HBsAg, anti-HIV antibodies and HCV-RNA were 3.5%, 13.8% and 41.9%, respectively. Spontaneous HCV clearance was evident in 16% of all of those who tested positive for anti-HCV antibodies. Independent risk factors for HCV-RNA positivity were age, gender, geographical region, duration of injecting drug use, history of imprisonment and HIV co-infection. In the age group ≤24 yrs, the rate of spontaneous HCV clearance was 43.5%. Overall, 59.8% of HCV infections were caused by HCV genotype 3 and 40.2% by HCV genotype 1. No other HCV genotypes were identified in this study. The IL28B SNP rs12979860 and rs8099917 were identified in 122 patients, and 75.4% of all participants had both favourable genotypes rs12979860 C/C and rs8099917 T/T. PMID:26263394

  3. Prevalence of molecular markers of anti-malarial drug resistance in Plasmodium vivax and Plasmodium falciparum in two districts of Nepal

    DEFF Research Database (Denmark)

    Ranjitkar, Samir; Schousboe, Mette L; Thomsen, Thomas;

    2011-01-01

    ABSTRACT: BACKGROUND: Sulphadoxine-pyrimethamine (SP) and chloroquine (CQ) have been used in treatment of falciparum and vivax malaria in Nepal. Recently, resistance to both drugs have necessitated a change towards artemisinin combination therapy (ACT) against Plasmodium falciparum in highly...... high levels of in vivo resistance are reflected at molecular level as well. METHODS: Finger prick blood samples (n=189) were collected from malaria positive patients from two high endemic districts and analysed for single nucleotide polymorphisms (SNPs) in the resistance related genes of P. falciparum...... endemic areas. However, SP is still used against P. falciparum infections in low endemic areas while CQ is used in suspected cases in areas with lack of diagnostic facilities. This study examines the prevalence of molecular markers of P. falciparum and Plasmodium vivax CQ and SP resistance to determine if...

  4. Comparative assessment on the prevalence of mutations in the Plasmodium falciparum drug-resistant genes in two different ecotypes of Odisha state, India.

    Science.gov (United States)

    Kar, Narayani Prasad; Chauhan, Kshipra; Nanda, Nutan; Kumar, Ashwani; Carlton, Jane M; Das, Aparup

    2016-07-01

    Considering malaria as a local and focal disease, epidemiological understanding of different ecotypes of malaria can help in devising novel control measures. One of the major hurdles in malaria control lies on the evolution and dispersal of the drug-resistant malaria parasite, Plasmodium falciparum. We herewith present data on genetic variation at the Single Nucleotide Polymorphism (SNP) level in four different genes of P. falciparum (Pfcrt, Pfmdr1, Pfdhfr, and Pfdhps) that confer resistance to different antimalarials in two different eco-epidemiological settings, i.e. Hilly-Forest (HF) and Riverine-Plain (RP), in a high malaria endemic district of Odisha state, India. Greater frequency of antimalarial resistance conferring SNPs and haplotypes was observed in all four genes in P. falciparum, and Pfdhps was the most variable gene among the four. No significant genetic differentiation could be observed in isolates from HF and RP ecotypes. Twelve novel, hitherto unreported nucleotide mutations could be observed in the Pfmdr1 and Pfdhps genes. While the Pfdhps gene presented highest haplotype diversity, the Pfcrt gene displayed the highest nucleotide diversity. When the data on all the four genes were complied, the isolates from HF ecotype were found to harbour higher average nucleotide diversity than those coming from RP ecotype. High and positive Tajima's D values were obtained for the Pfcrt and Pfdhfr genes in isolates from both the HF and RP ecotypes, with statistically significant deviation from neutrality in the RP ecotype. Different patterns of Linkage Disequilibrium (LD) among SNPs located in different drug-resistant genes were found in the isolates collected from HF and RP ecotypes. Whereas in the HF ecotype, SNPs in the Pfmdr1 and Pfdhfr were significantly associated, in the RP ecotype, SNPs located in Pfcrt were associated with Pfmdr1, Pfdhfr and Pfdhps. These findings provide a baseline understanding on how different micro eco-epidemiological settings

  5. The prevalence of primary HIV-1 drug resistance in newly reported HIV infections in Henan%河南省新确证HIV感染者中HIV原发耐药状况研究

    Institute of Scientific and Technical Information of China (English)

    刘佳; 许巍; 何翠; 燕晶; 邢辉; 薛秀娟; 孙定勇; 朱谦; 王哲

    2016-01-01

    目的 了解河南省新确证未进行抗病毒治疗的HIV感染者中HIV耐药株的流行状况.方法 收集河南省6个地区2013年1-6月和2014年1-6月新确证上报的HIV感染者的网络直报信息资料,并进行血样采集、基因型耐药检测和序列分析.结果 624例患者中有45例患者被检测到耐药株,原发耐药率为7.21%,属中度流行.单因素分析发现女性的原发耐药率高于男性(x2=11.463,P=0.001),20岁以下病例的原发耐药率高于其他年龄段(x2=8.969,P=0.011),文盲的原发耐药率高于其他文化水平的人群(x2=18.072,P=0.001),B亚型的原发耐药率高于其他亚型(x2=9.897,P=0.019),多因素分析发现女性中发生原发耐药的风险高(0R=2.194,95%CI:1.111~ 4.331).非核苷类反转录酶抑制剂(NNRTI)、核苷类反转录酶抑制剂(NRTI)和蛋白酶抑制剂(PI)耐药突变的发生率分别为4.97%、3.53%和1.12%.Ml84V/I(2.08%)和K103N/S(2.88%)分别是出现最多的NRTI和NNRTI耐药突变.有4例出现多个NRTI耐药突变.B亚型是624例中占比最多的基因亚型(51.76%,323/624例),其次为CRF07_BC (23.72%,148/624例)和CRF01_AE(19.71%,123/624例).结论 HIV耐药株在河南省新确证HIV感染者中出现了中度流行,应加强对HIV耐药株传播的监测,适时开展治疗前的耐药检测.%Objective To study the prevalence of primary HIV-1 drug resistance in newly reported HIV infected individuals receiving no antiviral treatment in Henan.Methods Network direct reporting information of newly reported HIV infection cases in six cities of Henan during January to June,2013 and January to June,2014 were collected,and blood samples were collected from the cases to conduct genotypic drug resistance test and sequence analysis.Results Primary HIV-1 drug resistance was detected in 45 of 624 newly reported HIV infection cases,the prevalence of primary HIV-1 drug resistance was 7.21%,which was classified as moderate.Univariate analysis

  6. Prevalência do consumo de álcool e drogas entre adolescentes: análise dos dados da Pesquisa Nacional de Saúde Escolar Prevalence of alcohol and drug consumption among adolescents: data analysis of the National Survey of School Health

    Directory of Open Access Journals (Sweden)

    Deborah Carvalho Malta

    2011-09-01

    Full Text Available OBJETIVO: Descrever a prevalência do consumo de álcool e outras drogas entre estudantes adolescentes. MÉTODO: Estudo transversal com amostra de conglomerados de 60.973 estudantes do nono ano do Ensino Fundamental de escolas públicas e privadas das capitais dos estados brasileiros e do Distrito Federal, em 2009. Foram analisadas as prevalências e os intervalos de confiança de 95% (IC95% do consumo de álcool e drogas. RESULTADOS: Para o conjunto dos alunos entrevistados, identificou-se o seguinte: experimentação de bebida alcoólica (71,4%; IC95% 70,8-72,0; consumo regular de álcool (27,3%; IC95% 26,7-28,0; embriaguez na vida (22,1%; IC95% 21,6-22,7; preocupação da família se chegasse bêbado em casa (93,8%; IC95% 93,3-94,2; problemas com uso de álcool (9,0%; IC95% 8,6-9,4 e experimentação de outras drogas (8,7%; IC95% 8,3-9,1. CONCLUSÃO: O estudo demonstra a extensão do problema do uso de álcool e drogas entre adolescentes brasileiros, destacando a facilidade com que os jovens entrevistados tiveram acesso ao álcool em festas, bares, lojas e até em suas próprias casas.OBJECTIVE: To describe the prevalence of alcohol and other drugs consumption, among adolescent students. METHODS: A cross-sectional study with conglomerate samples of 60,973 students at freshman year high school in public and private schools in capitals and the Federal District in Brazil, in 2009. The 95% confidence interval and the prevalence of alcohol and drug consumption were analyzed. RESULTS: For the set of surveyed students, the following were identified: experimenting alcoholic beverages (71.4%; 95%CI 70.8-72.0; regular alcoholic beverage consumption (27.3%; 95%CI 26.7-28.0; drunkenness in lifetime (22.1%; 95%CI 21.6-22.7; family is worried when the student gets home drunk (93.8%; 95%CI 93.3-94.2; problems with alcohol use (9.0%; 95%CI 8.6-9.4; consumption of other drugs (8.7%; 95%CI 8.3-9.1. CONCLUSION: This study shows the extension of the alcohol and

  7. Nuclear insurance in Canada

    International Nuclear Information System (INIS)

    Many years ago, a group of insurance companies founded an organization offering nuclear insurance, called Nuclear Insurance Association of Canada. The passage of Order-in-Council P.C. 1960-555 gave Atomic Energy of Canada Ltd. the power to indemnify suppliers, contractors, etc. against liability claims. The situation has remained essentially unchanged. In 1970 Parliament passed the Nuclear Liability Act, but it has never been proclaimed. The act sets mandatory levels of nuclear insurance as high as $75 million for firms involved in nuclear activity. It is expected that agreement between the insurers and government will be reached later this year (1976), so that the act can be proclaimed. (N.D.H.)

  8. High Prevalence of Infectious Diseases and Drug-Resistant Microorganisms in Asylum Seekers Admitted to Hospital; No Carbapenemase Producing Enterobacteriaceae until September 2015

    Science.gov (United States)

    Ravensbergen, Sofanne J.; Lokate, Mariëtte; Cornish, Darren; Kloeze, Eveline; Ott, Alewijn; Friedrich, Alex W.; van Hest, Rob; Akkerman, Onno W.; de Lange, Wiel C.; van der Werf, Tjip S.; Bathoorn, Erik

    2016-01-01

    Introduction The current refugee crisis emphasizes the need for information on infectious diseases and resistant microorganisms in asylum seekers with possible consequences for public health and infection control. Methods We collected data from asylum seekers admitted to our university hospital or who presented at the Emergency Department (n = 273). We collected general and demographic characteristics including country of origin, the reason of presentation, and the screening results of multi-drug resistant organisms. Results 67% of the patients were male with a median age of the study group of 24 years (IQR 15–33); 48% of the patients had an infectious disease—predominantly malaria with P. vivax or tuberculosis. Patients also reported with diseases which are less common—e.g. leishmaniasis, or even conditions rarely diagnosed in Europe—e.g. louse borne relapsing fever. A carriage rate of 31% for multi-drug resistant microorganisms (MDRO) was observed, with ESBL-expressing E.coli (n = 20) being the most common MDRO. No carriage of Carbapenemase Producing Enterobacteriaceae was found. Conclusion The current refugee crisis in Europe challenges hospitals to quickly identify and respond to communicable diseases and the carriage of MDRO. A rapid response is necessary to optimize the treatment of infectious diseases amongst asylum seekers to maximize infection control. PMID:27144599

  9. High Prevalence of Infectious Diseases and Drug-Resistant Microorganisms in Asylum Seekers Admitted to Hospital; No Carbapenemase Producing Enterobacteriaceae until September 2015.

    Directory of Open Access Journals (Sweden)

    Sofanne J Ravensbergen

    Full Text Available The current refugee crisis emphasizes the need for information on infectious diseases and resistant microorganisms in asylum seekers with possible consequences for public health and infection control.We collected data from asylum seekers admitted to our university hospital or who presented at the Emergency Department (n = 273. We collected general and demographic characteristics including country of origin, the reason of presentation, and the screening results of multi-drug resistant organisms.67% of the patients were male with a median age of the study group of 24 years (IQR 15-33; 48% of the patients had an infectious disease-predominantly malaria with P. vivax or tuberculosis. Patients also reported with diseases which are less common-e.g. leishmaniasis, or even conditions rarely diagnosed in Europe-e.g. louse borne relapsing fever. A carriage rate of 31% for multi-drug resistant microorganisms (MDRO was observed, with ESBL-expressing E.coli (n = 20 being the most common MDRO. No carriage of Carbapenemase Producing Enterobacteriaceae was found.The current refugee crisis in Europe challenges hospitals to quickly identify and respond to communicable diseases and the carriage of MDRO. A rapid response is necessary to optimize the treatment of infectious diseases amongst asylum seekers to maximize infection control.

  10. Prevalencia del consumo de drogas en pacientes atendidos en urgencias de adultos Drug consumption prevalence in adult patients attending the emergency room

    Directory of Open Access Journals (Sweden)

    Sofía Piñero-De Fuentes

    1998-05-01

    Full Text Available Objetivo. Conocer la asociación entre consumo de marihuana, cocaína y/o bazuco, y causas de ingreso de pacientes al Hospital Central de Valencia, Venezuela. Material y métodos. Se estudiaron 148 individuos recibidos en el área de urgencias, debido a lesiones por agresión (LA, accidentes de tránsito (AT, accidentes de trabajo (ATB, lesión autoinfringida (LAU e intoxicaciones (INT. Se aplicó un cuestionario y un análisis toxicológicos. Resultados. Se encontró un consumo de drogas, solas y/o asociadas, de 23.6% (13.5% cocaína, 7.4% marihuana y 2.7% ambas. De los pacientes positivos para cocaína, 50% ingresaron por LA; 20% por INT; 10% por LAU; 5% por ATB, y 15% por otras causas. De los positivos para marihuana, 36.4% ingresaron por AT; 27.3% por ATB; 18% por LA; 9.09% por INT, y 9.09% por otros motivos. Los ingresos por LA fueron de 75%, y por ATB, de 25%, para drogas en combinación. El consumo alcohólico asociado a cocaína fue de 50%; a marihuana, de 9%; a combinación, de 25%. Conclusiones. Estos hallazgos demuestran que uno de cada cuatro ingresos por causa traumática está asociado al abuso de drogas, solas o en combinación, lo que revela una estrecha relación causa-efecto.Objective. To determine the association between patient admission due to trauma and the consumption of marihuana, cocaine and bazooka (basic cocaine paste at the Central Hospital of Valencia, Venezuela. Material and methods. 148 subjects were studied who had entered the emergency room due to lesions caused by aggression (AL, traffic accidents (TA, work-related accidents (WRA, self-inflicted injury (SII and intoxication (INT. A questionnaire was applied and toxicology analyses performed. Results. Drug consumption, alone or in combination, was found in 23.6% of individuals (13.5% cocaine, 7.4% marihuana and 2.7% both. Of the cocaine positive, 50% entered for AL, 20% for INT, 10% for SII, 5% for WRA and 15% for other causes. Of the marihuana positive, 36

  11. Canada's medical isotope strategy

    International Nuclear Information System (INIS)

    This paper details Canada's medical isotope strategy and the role of the Canadian Government in the security of the isotope supply chain. The government's role is to promote health and safety of Canadians, establish appropriate regulatory framework, allow the markets to work, facilitate international collaboration, fund high-risk early stage research and development, encourage private sector investment in innovation and support and respect environmental and non-proliferation goals.

  12. Canada's Global Partnership Program

    International Nuclear Information System (INIS)

    Curbing the proliferation of biological weapons (BW) is an essential element of the Global Partnership Against the Spread of Weapons and Materials of Mass Destruction. At the Kananaskis Summit in June 2002, G8 Leaders committed to prevent terrorists, or those that harbour them, from acquiring or developing biological weapons and related materials, equipment and technology. To this end, Canada's Global Partnership Program is investing heavily in biological non-proliferation activities in countries of the former Soviet Union. A comprehensive strategy has been developed to help improve biological safety (biosafety) and biological security (biosecurity) with provision for addressing dual-use concerns. Raising awareness and creating a self-sustaining culture of biosecurity is a key driver of the program. Through this strategy, Canada is assisting various FSU countries to: develop and implement effective and practical biosafety/biosecurity standards and guidelines; establish national and/or regional biosafety associations; develop and deliver effective biosafety and biosecurity training; put in place enhanced physical security measures and equipment. In addition to biosafety and biosecurity, the GPP supports a broad range of Biological Non-Proliferation projects and initiatives, including dozens of projects aimed at redirecting former biological weapons scientists. To date, most of these activities have been supported through Canada's contribution to the International Science and Technology Center (ISTC) and the Science and Technology Centre Ukraine (STCU).(author)

  13. Canada's reactor exports

    International Nuclear Information System (INIS)

    A brief sketch of the development of Canada's nuclear exports is presented and some of the factors which influence the ability to export reactors have been identified. The potential market for CANDUs is small and will develop slowly. The competition will be tough. There are few good prospects for immediate export orders in the next two or three years. Nonetheless there are reasonable opportunities for CANDU exports, especially in the mid-to-late 1980s. Such sales could be of great benefit to Canada and could do much to sustain the domestic nuclear industry. Apart from its excellent economic and technical performance, the main attraction of the CANDU seems to be the autonomy it confers on purchasing countries, the effectiveness with which the associated technology can be transferred, and the diversification it offers to countries which wish to reduce their dependence on the major industrial suppliers. Each sales opportunity is unique, and marketing strategy will have to be tailored to the customer's needs. Over the next decade, the factors susceptible to Canadian government action which are most likely to influence CANDU exports will be the political commitment of the government to those reactor exports, the performance established by the four 600 MWe CANDUs now nearing completion, the continuing successful operation of the nuclear program in Ontario, and the co-ordination of the different components of Canada's nuclear program (AECL, nuclear industry, utilities, and government) in putting forth a coherent marketing effort and following through with effective project management

  14. Environmental performance reviews: Canada

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-09-01

    OECD's comprehensive 2004 report on Canada's environmental policies and programmes systematically examines policy related to air, water, and nature/biodiversity as well as the interface between environmental policy and economic policy, social policy, and specific sectors. It finds that while Canada has made satisfactory progress since 1985, there are still significant challenges, and the report makes specific recommendations for more use of economic instruments and use of the polluter and user pays principles, rationalising water governance, strengthening nature protection, reducing energy intensity, implementing climate change policies, reviewing environmentally related taxes, and implementing marine and aid commitments. Coal provides about 20% of Canada's electric power. Most direct subsidisation of the fossil fuel supply industries (upstream oil, gas and coal) has been reduced. The report recommends subsidies to the mining industry for exploration should also be phased out. Recent measurements indicate emissions of mercury are increasing, mainly due to long-range transboundary air pollution from coal-burning plants. 42 figs., 24 tabs.

  15. Transnational surrogacy: Canada's contradictions.

    Science.gov (United States)

    Lozanski, Kristin

    2015-01-01

    Transnational commercial surrogacy represents a form of medical tourism undertaken by intended parents who seek to hire women in other countries, increasingly often in the global South, as surrogates. While much of the scholarly literature focuses on the conditions of surrogacy within host countries, such as India, there has been limited analysis of transnational surrogacy focused upon origin countries. In this article, I build upon the scholarship that explores the impact of host country structures on transnational surrogacy, with special attention to the significance of Canadian citizenship policy through analysis of legislation and policy vis-à-vis transnational commercial surrogacy. The Canadian case demonstrates clear contradictions between the legislation and policy that is enacted domestically to prohibit commercial surrogacy within Canada and legislation and policy that implicitly sanctions commercial surrogacy through the straightforward provision of citizenship for children born of such arrangements abroad. The ethical underpinnings of Canada's domestic prohibition of commercial surrogacy, which is presumed to exploit women and children and to impede gender equality, are violated in Canada's bureaucratic willingness to accept children born of transnational commercial surrogacy as citizens. Thus, the ethical discourses apply only to Canadian citizens within Canadian geography. The failure of the Canadian government to hold Canadian citizens who participate in transnational commercial surrogacy to the normative imperatives that prohibit the practice within the country, or to undertake a more nuanced, and necessarily controversial, discussion of commercial surrogacy reinforces transnational disparities in terms of whose bodies may be commodified as a measure of gendered inequality. PMID:25308235

  16. Prevalences and associated risk factors of HCV/HIV co-infection and HCV mono-infection among injecting drug users in a methadone maintenance treatment program in Taipei, Taiwan

    Directory of Open Access Journals (Sweden)

    Yen Yung-Feng

    2012-12-01

    Full Text Available Abstract Background Injecting drug users (IDUs in Taiwan contributed significantly to an HIV/AIDS epidemic in 2005. In addition, studies that identified risk factors of HCV/HIV co-infection among IDUs were sparse. This study aimed to identify risk factors of HCV/HIV co-infection and HCV mono-infection, as compared with seronegativity, among injecting drug users (IDUs at a large methadone maintenance treatment program (MMTP in Taipei, Taiwan. Methods Data from enrollment interviews and HCV and HIV testing completed by IDUs upon admission to the Taipei City Hospital MMTP from 2006–2010 were included in this cross-sectional analysis. HCV and HIV testing was repeated among re-enrollees whose HCV or HIV test results were negative at the preceding enrollment. Backward stepwise multinomial logistic regression was used to identify risk factors associated with HCV/HIV co-infection and HCV mono-infection. Results Of the 1,447 IDUs enrolled, the prevalences of HCV/HIV co-infection, HCV mono-infection, and HIV mono-infection were 13.1%, 78.0%, and 0.4%, respectively. In backward stepwise multinomial regression analysis, after controlling for potential confounders, syringe sharing in the 6 months before MMTP enrollment was significantly positively associated with HCV/HIV co-infection (adjusted odds ratio [AOR]=27.72, 95% confidence interval [CI] 13.30–57.76. Incarceration was also significantly positively associated with HCV/HIV co-infection (AOR=2.01, 95% CI 1.71–2.37 and HCV mono-infection (AOR=1.77, 95% CI 1.52–2.06, whereas smoking amphetamine in the 6 months before MMTP enrollment was significantly inversely associated with HCV/HIV co-infection (AOR=0.44, 95% CI 0.25–0.76 and HCV mono-infection (AOR=0.49, 95% CI 0.32–0.75. HCV seroincidence was 45.25/100 person-years at risk (PYAR; 95% CI 24.74–75.92/100 PYAR and HIV seroincidence was 0.53/100 PYAR (95% CI 0.06–1.91/100 PYAR among re-enrolled IDUs who were HCV- or HIV-negative at the

  17. Prevalencia de abuso sexual en estudiantes y su relación con el consumo de drogas Prevalence of sexual abuse in students and its relationship with drug consumption

    Directory of Open Access Journals (Sweden)

    Luciana Ramos-Lira

    1998-05-01

    particularidades de cada género.Objective. To determine the prevalence of sexual abuse among high school (secondary and preparatory students, male and female, throughout Mexico, and its relationship with drug abuse. Material and methods. Data were obtained from the National Survey of Drug Use in Schools applied in November and December, 1991. A total of 61 779 students, 51.8% men and 47.1% women, with a mean age of 14.4 years completed the self-applied questionnaire. Sexual abuse was explored from the perspective of the abusers and of the victims. Results. The prevalence of sexual abuse in adolescent victims was 4.3% and no statistically significant differences were found between sexes. The prevalence of sexual aggressors was 2.5%. Men coerced someone else in a higher proportion than women. Adolescent women experienced sexual abuse at a younger age than men and they also reported a higher percentage of intrafamily abuse. Men reported friends as the most frequent aggressors. Victims and aggressors of both sexes reported a significantly higher drug consumption than students without these antecedents. Conclusions. The differences in the experience of sexual abuse between men and women are described. In particular, the fact that sexual abuse in men mainly occurs outside the family sphere, while in women it is mainly within the family and at a younger age than in men. Additionally, the need for further research focusing on the consequences on mental health of infantile and adolescent sexual abuse and drug consumption is emphasized, considering the characteristics of each gender.

  18. A alta prevalência de prescrições de medicamentos off-label e não licenciados em unidade de terapia intensiva pediátrica brasileira High prevalence of off-label and unlicensed drug prescribing in a Brazilian intensive care unit

    Directory of Open Access Journals (Sweden)

    Lilian de Abreu Ferreira

    2012-02-01

    Full Text Available OBJETIVO: Descrever o uso e determinar a prevalência de medicamentos de uso off-label enão licenciados em prescrições na unidade de terapia intensiva pediátrica de um hospital no sudeste do Brasil. MÉTODOS: Estudo transversal envolvendo os pacientes internados na unidade de terapia intensiva pediátrica durante o período de maio de 2008 a janeiro de 2009. A classificação quanto aos critérios de aprovação da Agência de Vigilância Sanitária (Anvisa foi baseada em seu bulário eletrônico e no Dicionário de Especialidades Farmacêuticas e as análises realizadas no software R. RESULTADOS: Foram analisados 1.054 itens de prescrição de 73 pacientes. O gênero feminino foi o mais frequente (52% e a idade dos pacientes variou de zero a 16 anos. Observou-se que 23,4% dos medicamentos foram prescritos de modo off-label, 12,6% não licenciados e 1,4% foram classificados em ambas as razões; 86% receberam ao menos um item de uso off-label e 67% ao menos um item de uso não licenciado. Os grupos terapêuticos mais prescritos foram os antibacterianos de uso sistêmico, os analgésicos, psicolépticos e antiasmáticos. CONCLUSÃO: Os resultados do presente trabalho confirmam a alta prevalência do uso off-label e não licenciados dos medicamentos em unidade de terapia intensiva pediátrica.OBJECTIVE: To describe the use and determine the prevalence of off-label and unlicensed drug use prescribing in a pediatric intensive care unit in a Southeastern Brazilian hospital METHODS: Cross-sectional study of inpatients in a pediatric intensive care unit from May 2008 through January 2009. The classification according to the Brazilian regulatory agency (Agência de Vigilância Sanitária - Anvisa approval criteria was based on the Anvisa electronic package insert list, Pharmaceuticals Dictionary, and the analysis was conducted through R software. RESULTS: We analysed 1,054 prescription items for 73 patients. Females predominated (52%, and the

  19. Declining sex ratios in Canada

    OpenAIRE

    Allan, B. B.; Brant, R; Seidel, J E; Jarrell, J F

    1997-01-01

    OBJECTIVE: To examine the trends in the proportion of annual live births that were male in Canada and to compare the trends with those in the United States. DESIGN: Analysis of census data. SETTING: Canada as a whole and 4 main regions (West, Ontario, Quebec and Atlantic). SUBJECTS: All live births from 1930 to 1990. OUTCOME MEASURES: Sex ratio (expressed as the proportion of total live births that were male [male proportion]) overall and by region. RESULTS: The male proportion in Canada decr...

  20. Prevalência do uso de drogas entre escolares do ensino médio do Município de São José do Rio Preto, São Paulo, Brasil Drug abuse prevalence among secondary school students in São José do Rio Preto, São Paulo State, Brazil

    Directory of Open Access Journals (Sweden)

    Elissandro de Freitas Silva

    2006-06-01

    Full Text Available Este estudo dispõe-se a estudar as taxas de prevalência de consumo de substâncias psicoativas entre escolares do ensino médio no Município de São José do Rio Preto, São Paulo, Brasil, e sua distribuição por sexo e período escolar. Utilizou-se um estudo de corte transversal em escolas públicas do ensino médio do município com uma amostragem de conglomerados. Aplicaram-se 1.041 questionários autopreenchíveis de maneira coletiva nas classes, mantidos sem identificação. As prevalências do consumo na vida foram: álcool 77%, tabaco 28,7%, solventes 18,1%, maconha 12,1%, anfetamínicos 3,7%, cocaína 3,3%, alucinógenos 3,1%, e crack 1,4%. O uso na semana de maconha foi o maior (2,8%, seguido dos solventes (1,3%. O sexo masculino consumiu mais álcool, maconha, cocaína e crack que o feminino. O período noturno teve prevalência significantemente superior para o tabaco, maconha, cocaína e alucinógeno. No presente estudo, verificou-se uma caracterização da prevalência do consumo de substâncias psicoativas em São José do Rio Preto semelhante à encontrada em outros estudos brasileiros.This study investigates the prevalence of drug consumption among secondary school students in São José do Rio Preto, São Paulo State, Southeast Brazil, and its distribution in relation to gender and grade in school. A cross-sectional survey was carried out in São José do Rio Preto. A self-applied questionnaire was answered by a proportional sample of 1,041 teenagers enrolled in 9th, 10th, and 11th grades in public schools. Lifetime consumption of psychoactive substances was: alcohol 77%, tobacco 28.7%, solvents 18.1%, marijuana 12.1%, amphetamines 3.7%, cocaine 3.3%, hallucinogens 3.1%, and crack 1.4%. Weekly use of marijuana was the highest (2.8%, followed by solvents (1.3%. Males consumed more alcohol, marijuana, cocaine, and crack than females. Nighttime use of tobacco, marijuana, cocaine, and hallucinogens was observed. In the present

  1. Prevalence of alcohol, tobacco and street drugs consumption in adult Latin American immigrants Prevalencia de consumo de alcohol, tabaco y drogas ilícitas en inmigrantes latinoamericanos adultos Prevalência do consumo de álcool, tabaco e drogas ilícitas em adultos imigrantes latino-americanos

    Directory of Open Access Journals (Sweden)

    José Rafael González-López

    2012-06-01

    Full Text Available To estimate the prevalence of alcohol, tobacco and illicit drug consumption (through the self-report in adult Latin-American immigrants of Seville, a cross-sectional descriptive study was carried out in a representative sample of 190 immigrants. The results showed that 61.4% of the participants had consumed alcohol in previous month before data collection, although 13.2% of them were at risk of alcoholism. Moreover, 30.0% were smokers. In addition, 5.3% of the interviewed people had consumed illicit psychoactive substances in the previous six months (Marihuana: 3.7%, hashish: 1.1% and cocaine: 0.5%. For all substances under analysis, the consumption prevalence was much higher in men from 25 to 39 years of age. In conclusion, prevalence levels of this consumption were high among the studied immigrants. Nurses could train the population in the prevention of these risk behaviors through preventive practices.Con el fin de estimar la prevalencia por autorreporte del consumo de alcohol, tabaco y drogas ilícitas en la población adulta de inmigrantes latinoamericanos en Sevilla, se realizó un estudio descriptivo de corte transversal en una muestra representativa de 190 inmigrantes. Los resultados mostraron que el 61,4% de los sujetos bebió alcohol en el mes anterior a la recolección de datos, y el 13,2% de los participantes mostró tener riesgo de alcoholismo. El 30,0% ya era fumador. El 5,3% de los encuestados ha consumido drogas ilícitas en los últimos seis meses (marihuana: 3,7%, el hachís, la cocaína un 1,1% y 0,5%. Para todas las sustancias investigadas, la prevalencia de consumo fue mayor en hombres de 25-39 años. Se concluye que los inmigrantes tienen una alta prevalencia de consumo de drogas. La enfermera puede prevenir estos comportamientos de riesgo mediante la implementación de prácticas educativas.Para estimar a prevalência de autorrelato de consumo de álcool, tabaco e drogas ilícitas da população adulta de latino

  2. Intensive hog farming operations and self-reported health among nearby rural residents in Ottawa, Canada

    OpenAIRE

    Challacombe Laurel; Ali Amira; Villeneuve Paul J; Hebert Sophie

    2009-01-01

    Abstract Background In 2004, hog farming operations were introduced in the village of Sarsfield in the eastern part of Ottawa, Canada. This study evaluates the health-related quality of life (HRQOL), and the prevalence of respiratory conditions among adults and children who lived in proximity to this farm. Methods A cross-sectional survey was administered to a random sample of residents from seven rural communities in the eastern part of Ottawa, Canada. We analyzed self-reported questionnaire...

  3. Canada's disposal concept

    International Nuclear Information System (INIS)

    A concept for the safe and permanent disposal of nuclear fuel wastes from Canada's CANDU reactors has been developed by Atomic Energy of Canada Ltd. (AECL). The waste would be placed in an engineered disposal vault 500 to 1000 m below the surface in plutonic rock of the Canadian Shield. The multiple barriers to retain the waste and retard the release of radioactivity would be the waste form, the containers, buffer and backfill, and the rock overlying the vault. Numerous research programmes have been carried out to develop the technology for the concept. These include work on materials corrosion and failure mechanisms to assess the performance of the used fuel containers. Predictive modelling has shown that more than 97% of ASTM Grade 2 titanium containers will retain their integrity, even under pessimistic assumptions, for 1200-6000 years after emplacement, and even longer times may be achieved with other grades of titanium or copper. Other research has been aimed at vault sealing, at site characterization for an underground research laboratory and at the development of a methodology for assessing radiological and environmental effects after closure of the facility. A review of the safety and environmental impacts of the concept is now being carried out by an independent panel appointed by the government. (2 figures, 3 references) (UK)

  4. Canada's Clean Air Act

    International Nuclear Information System (INIS)

    This paper provided an outline of Canada's Clean Air Act and examined some of the regulatory changes that will occur as a result of its implementation. The Act is being introduced to strengthen the legislative basis for taking action on reducing air pollution and GHGs, and will allow the government to regulate both indoor and outdoor air pollutants and GHGs. The Act will require the Ministers of the Environment and Health to establish national air quality objectives, as well as to monitor and report on their attainment. The Canadian Environmental Protection Act will be amended to enable the government to regulate the blending of fuels and their components. The Motor Vehicle Fuel Consumption Standards Act will also be amended to enhance the government's authority to regulate vehicle fuel efficiency. The Energy Efficiency Act will also be expanded to allow the government to set energy efficiency standards and labelling requirements for a wider range of consumer and commercial products. The Act will commit to short, medium and long-term industrial air pollution targets. Regulations will be proposed for emissions from industry; on-road and off-road vehicles and engines; and consumer and commercial products. It was concluded that the Government of Canada will continue to consult with provinces, territories, industries and Canadians to set and reach targets for the reduction of both indoor and outdoor air pollutants and GHG emissions. 6 figs

  5. Energy in Canada

    International Nuclear Information System (INIS)

    Canada's historical energy consumption, its current consumption and its likely requirements by the turn of the century are reviewed. It is estimated that at least 50% more energy will be required in the year 2000 than is consumed now, assuming a minimum 2% growth rate in primary energy consumption. Both non-renewable and renewable energy resources are examined in the light of these future energy requirements and the need to substitute alternative energy sources for conventional oil in various end uses. The comparative risks involved in energy production are also reviewed. Most of the increase in energy consumption and the substitution of oil over the next 20 years is likely to be met by conventional energy sources, since indigenous reserves are extensive and the relevant technologies well-established. Coal, nuclear and hydro reserves could cover the increase in energy demand until well into the next century, and natural gas reserves are sufficient to bridge the gap during conversion from oil to other energy sources. Nuclear power using advanced fuel cycles and oil from tar sands offer Canada long-term security. The penetration of unconventional energy sources is likely to be relatively small during the next 20 years. However, the most promising may become significant in the next century. (author)

  6. A hepatitis A, B, C and HIV prevalence and risk factor study in ever injecting and non-injecting drug users in Luxembourg associated with HAV and HBV immunisations

    Directory of Open Access Journals (Sweden)

    Schmit Jean-Claude

    2011-05-01

    Full Text Available Abstract Background In Luxembourg, viral hepatitis and HIV infection data in problem drug users (PDUs are primarily based on self-reporting. Our study aimed to determine the prevalence of HAV, HBV, HCV and HIV infections in ever injecting (IDUs and non-injecting drug users (nIDUs including inherent risk factors analysis for IDUs. Secondary objectives were immunisation against HAV and HBV, referral to care and treatment facilities as well as reduction in risk behaviour. Methods A nationwide, cross-sectional multi-site survey, involving 5 in-, 8 out-treatment and 2 prison centres, included both an assisted questionnaire (n = 368 and serological detection of HIV and Hepatitis A, B, C (n = 334. A response rate of 31% resulted in the participation of 310 IDUs and 58 nIDUs. Risk factors such as drug use, sexual behaviour, imprisonment, protection and health knowledge (HAV, HBV status and immunisations, HCV, HIV, piercing/tattoo and use of social and medical services were studied by means of chi2 and logistic models. Results Seroprevalence results for IDUs were 81.3% (218/268, 95%CI=[76.6; 86.0] for HCV, 29.1% (74/254, 95%CI=[25.5;34.7 ] for HBV (acute/chronic infection or past cured infection, 2.5% (5/202, 95%CI=[0.3; 4.6] for HIV-1 and 57.1% (108/189, 95%CI=[50.0; 64.1] for HAV (cured infections or past vaccinations. Seroprevalence results for nIDUs were 19.1% (9/47, 95%CI=[7.9;30.3] for HCV, 8.9% (4/45, 95%CI=[0.6;17.2] for HBV (acute/chronic infection or past cured infection, 4.8% (2/42, 95%CI=[-1.7;11.3] for HIV-1 and 65.9% (27/41, 95%CI=[51.4;80.4] for HAV. Prisoners showed the highest rates for all infections. Age, imprisonment and setting of recruitment were statistically associated with HCV seropositivity. Age, speedball career and nationality were significantly associated with HBV seropositivity. Only 56% of the participants in outpatient centres collected their serology results and 43 doses of vaccine against HAV and/or HBV were administered

  7. The clinical characteristics of adolescents reporting methamphetamine as their primary drug of choice: an examination of youth admitted to inpatient substance-abuse treatment in northern British Columbia, Canada, 2001-2005.

    Science.gov (United States)

    Callaghan, Russell C; Brands, Bruna; Taylor, Lawren; Lentz, Tim

    2007-03-01

    We conducted a 5-year medical-chart review of all admissions to an inpatient adolescent substance-abuse program. Youth indicating methamphetamine as their primary drug of choice did not have worse dropout rates or a more severe baseline profile on 4 Addiction Severity Index subscales (Family/Social Conflict, Legal, Psychological, and Medical), compared to adolescents reporting another drug of choice. PMID:17321434

  8. Radioactive waste management in Canada

    International Nuclear Information System (INIS)

    This bibliography is an up-date to AECL-6186(Rev 3), 1952-1982, 'Radioactive Waste Management in Canada AECL Publications and Other Literature' compiled by Dianne Wallace. Canadian publications from outside contractors concerning the Canadian Nuclear Fuel Waste Management Program are included in addition to Atomic Energy of Canada Limited reports and papers. 252 refs

  9. OECD Economic Surveys: Canada 2012

    Science.gov (United States)

    OECD Publishing (NJ3), 2012

    2012-01-01

    Canada weathered the global economic crisis well, mainly reflecting sustained growth in domestic pending, and the economy is continuing to grow despite the persistence of international turbulence, most recently stemming from the euro zone sovereign debt crisis. In Canada's case, several factors are acting in its favour. Federal fiscal plans are…

  10. Farming. Canada at Work Series.

    Science.gov (United States)

    Love, Ann; Drake, Jane

    This book is part of the Canada At Work series that introduces children to the people, machines, work and environmental concerns involved in bringing to market the products from important Canadian natural resources. This volume features a year-round look at two kinds of agriculture in Canada. On the vegetable farm, children find out about spring…

  11. Quality of Artemisinin-Based Combination Formulations for Malaria Treatment: Prevalence and Risk Factors for Poor Quality Medicines in Public Facilities and Private Sector Drug Outlets in Enugu, Nigeria

    Science.gov (United States)

    Kaur, Harparkash; Allan, Elizabeth Louise; Mamadu, Ibrahim; Hall, Zoe; Ibe, Ogochukwu; El Sherbiny, Mohamed; van Wyk, Albert; Yeung, Shunmay; Swamidoss, Isabel; Green, Michael D.; Dwivedi, Prabha; Culzoni, Maria Julia; Clarke, Siân; Schellenberg, David; Fernández, Facundo M.; Onwujekwe, Obinna

    2015-01-01

    Background Artemisinin-based combination therapies are recommended by the World Health Organisation (WHO) as first-line treatment for Plasmodium falciparum malaria, yet medication must be of good quality for efficacious treatment. A recent meta-analysis reported 35% (796/2,296) of antimalarial drug samples from 21 Sub-Saharan African countries, purchased from outlets predominantly using convenience sampling, failed chemical content analysis. We used three sampling strategies to purchase artemisinin-containing antimalarials (ACAs) in Enugu metropolis, Nigeria, and compared the resulting quality estimates. Methods ACAs were purchased using three sampling approaches - convenience, mystery clients and overt, within a defined area and sampling frame in Enugu metropolis. The active pharmaceutical ingredients were assessed using high-performance liquid chromatography and confirmed by mass spectrometry at three independent laboratories. Results were expressed as percentage of APIs stated on the packaging and used to categorise each sample as acceptable quality, substandard, degraded, or falsified. Results Content analysis of 3024 samples purchased from 421 outlets using convenience (n=200), mystery (n=1,919) and overt (n=905) approaches, showed overall 90.8% ACAs to be of acceptable quality, 6.8% substandard, 1.3% degraded and 1.2% falsified. Convenience sampling yielded a significantly higher prevalence of poor quality ACAs, but was not evident by the mystery and overt sampling strategies both of which yielded results that were comparable between each other. Artesunate (n=135; 4 falsified) and dihydroartemisinin (n=14) monotherapy tablets, not recommended by WHO, were also identified. Conclusion Randomised sampling identified fewer falsified ACAs than previously reported by convenience approaches. Our findings emphasise the need for specific consideration to be given to sampling frame and sampling approach if representative information on drug quality is to be obtained

  12. Quality of artemisinin-based combination formulations for malaria treatment: prevalence and risk factors for poor quality medicines in public facilities and private sector drug outlets in Enugu, Nigeria.

    Directory of Open Access Journals (Sweden)

    Harparkash Kaur

    Full Text Available Artemisinin-based combination therapies are recommended by the World Health Organisation (WHO as first-line treatment for Plasmodium falciparum malaria, yet medication must be of good quality for efficacious treatment. A recent meta-analysis reported 35% (796/2,296 of antimalarial drug samples from 21 Sub-Saharan African countries, purchased from outlets predominantly using convenience sampling, failed chemical content analysis. We used three sampling strategies to purchase artemisinin-containing antimalarials (ACAs in Enugu metropolis, Nigeria, and compared the resulting quality estimates.ACAs were purchased using three sampling approaches--convenience, mystery clients and overt, within a defined area and sampling frame in Enugu metropolis. The active pharmaceutical ingredients were assessed using high-performance liquid chromatography and confirmed by mass spectrometry at three independent laboratories. Results were expressed as percentage of APIs stated on the packaging and used to categorise each sample as acceptable quality, substandard, degraded, or falsified.Content analysis of 3024 samples purchased from 421 outlets using convenience (n=200, mystery (n=1,919 and overt (n=905 approaches, showed overall 90.8% ACAs to be of acceptable quality, 6.8% substandard, 1.3% degraded and 1.2% falsified. Convenience sampling yielded a significantly higher prevalence of poor quality ACAs, but was not evident by the mystery and overt sampling strategies both of which yielded results that were comparable between each other. Artesunate (n=135; 4 falsified and dihydroartemisinin (n=14 monotherapy tablets, not recommended by WHO, were also identified.Randomised sampling identified fewer falsified ACAs than previously reported by convenience approaches. Our findings emphasise the need for specific consideration to be given to sampling frame and sampling approach if representative information on drug quality is to be obtained.

  13. A Case for Developing Community Drug Indicators

    Science.gov (United States)

    Loughran, Hilda; McCann, Mary Ellen

    2011-01-01

    The EU Action Plan on Drugs (2005-2008) calls for member states of the European Union to provide information on five key epidemiological indicators. These are: general population surveys, prevalence and patterns of problem drug use, drug related infectious diseases, drug related deaths and mortality of drug users, and demand for drug treatment.…

  14. Recognition of sleep paralysis among normal adults in Canada and in Japan.

    Science.gov (United States)

    Fukuda, K; Ogilvie, R D; Takeuchi, T

    2000-06-01

    There were no differences between Canada and Japan in the prevalence and symptoms of sleep paralysis (SP), but many more Canadians considered SP to be a dream. The difference was considered to be derived from the fact that there is a common expression for SP in Japan but there is not one in Canada. Then, we investigated why there are individuals who consider SP to be a dream and others who do not, and found that many Japanese who regarded it as a dream did not report the symptom of 'unable to move', while in Canada, self-evaluation of spirituality was different between the two groups. PMID:11186082

  15. Prevalência e fatores associados ao uso de antiinflamatórios não-esteróides por pacientes submetidos a endoscopia digestiva alta, Belo Horizonte, Minas Gerais, 2000 Prevalence of and factors associated with nonsteroidal anti-inflammatory drug use by patients submitted to upper endoscopy, Belo Horizonte, Minas Gerais, 2000

    Directory of Open Access Journals (Sweden)

    Andréia Queiroz Ribeiro

    2005-09-01

    Full Text Available OBJETIVO: Determinar a prevalência e os fatores associados ao uso de AINE por pacientes submetidos a endoscopia digestiva alta no Hospital das Clínicas da UFMG. MÉTODOS: Estudo transversal de uma amostra de 533 pacientes com idade igual ou superior a 17 anos, com endoscopia previamente marcada na Seção de Endoscopia do Hospital das Clínicas da Universidade Federal de Minas Gerais. Os dados foram coletados por meio de entrevistas. Foram considerados quatro grupos de variáveis exploratórias: sociodemográficas, relacionadas aos hábitos de vida, relacionadas à história de morbidades e relacionadas ao uso de medicamentos. Os dados foram submetidos às análises estatísticas bivariada e multivariada. RESULTADOS E CONCLUSÕES: Entre os entrevistados, 34,1% relataram algum uso de AINE no período de 1 mês anterior à realização da endoscopia. Os AINE mais utilizados foram o ácido acetilsalicílico e o diclofenaco. Os fatores associados ao uso de AINE foram: sexo feminino (OR = 2,07; IC 95% = 1,28-3,34, renda igual ou superior a 3 salários mínimos (OR = 3,20; IC 95% = 1,74-5,90, uso de álcool (OR = 2,43; IC 95% = 1,39-4,24, presença de sintomas gastrintestinais (OR = 1,82; IC 95% = 1,18-2,80, uso regular de 4 ou mais medicamentos (OR = 4,33; IC 95% = 2,49-7,54 e história prévia de úlcera e/ou hemorragia digestiva (OR = 0,40; IC 95% = 0,22-0,75. Estes resultados mostram semelhanças aos observados em países desenvolvidos. Além disso, alertam para a necessidade de maior atenção por profissionais de saúde para com os subgrupos de uso evidenciados.INTRODUCTION: The objective was to determine the prevalence and the factors associated with nonsteroidal anti-inflammatory drugs (NSAID used by patients submitted to upper endoscopy at Hospital das Clínicas/UFMG, Belo Horizonte, MG. METHODS: Cross-sectional study of a 533 patients, aged 17 or older, whose endoscopies had been previously scheduled at the Endoscopy Section of Hospital

  16. Western Canada uranium perspective

    International Nuclear Information System (INIS)

    The current situation in the exploration for uranium in British Columbia, the Yukon, the Northwest Territories, and Saskatchewan is reviewed. A moratorium on exploration has been in effect in British Columbia since 1980; it is due to expire in 1987. Only the Blizzard deposit appears to have any economic potential. The Lone Gull discovery in the Thelon Basin of the Northwest Territories has proven reserves of more than 35 million pounds U3O8 grading 0.4%. Potentially prospective areas of the northern Thelon Basin lie within a game sanctuary and cannot be explored. Exploration activity in Saskatchewan continues to decline from the peak in 1980. Three major deposits - Cluff Lake, Rabbit Lake and Key Lake - are in production. By 1985 Saskatchewan will produce 58% of Canada's uranium, and over 13% of the western world's output. (L.L.) (3 figs, 2 tabs.)

  17. Gambling households in Canada.

    Science.gov (United States)

    MacDonald, Martha; McMullan, John L; Perrier, David C

    2004-01-01

    This paper examines the distribution of gambling dollars in Nova Scotia, Saskatchewan and Canada and studies the impact of this spending on households. We focus first on how gambling expenditures are related to the level and source of household income as well as to other demographic characteristics such as age, education, household composition, geographical area, and sources of income. Next we analyze how gambling expenditures are distributed among those households that gamble. We show how expenditure patterns differ in the intensity of gambling as measured by the proportion of household income or total amount of dollars spent on gambling. Then we study the affects that gambling has on spending on household necessities, changes in net worth, retirement savings and household debt. Finally we determine whether gambling expenditures act as a substitute or a complement to other recreational spending on entertainment products and services. Throughout the paper we offer a comparative analysis of provincial and national data. PMID:15353922

  18. Mackenzie River Delta, Canada

    Science.gov (United States)

    2007-01-01

    The Mackenzie River in the Northwest Territories, Canada, with its headstreams the Peace and Finley, is the longest river in North America at 4241 km, and drains an area of 1,805,000 square km. The large marshy delta provides habitat for migrating Snow Geese, Tundra Swans, Brant, and other waterfowl. The estuary is a calving area for Beluga whales. The Mackenzie (previously the Disappointment River) was named after Alexander Mackenzie who travelled the river while trying to reach the Pacific in 1789. The image was acquired on August 4, 2005, covers an area of 55.8 x 55.8 km, and is located at 68.6 degrees north latitude, 134.7 degrees west longitude. The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate.

  19. Canada No. 1 in business

    International Nuclear Information System (INIS)

    Canada has for the fifth time in a row been chosen the best industrialized country in the world in which to initiate and run a business. The Norwegian interest in Canada has grown strongly the last years and Norwegian companies have invested over 20 billion NOK there. Canada is the perfect gateway to the large markets in the USA. Norway is currently Canada's 15th largest trading partner. In addition to low costs and strategic location, Canada has the most highly educated workforce in the world. A company on the Canadian side of the US border has the same access to the American market as a US-based company. There is even a Norwegian company in Canada that exports 100 per cent of its products across the border to the USA. The trade between the USA and Canada is more extensive than between the USA and all the EU countries together. Furthermore, Canadian companies concentrating on research and education are given a generous tax credit

  20. Nuclear fuel activities in Canada

    International Nuclear Information System (INIS)

    Nuclear fuel activities in Canada are considered in the presentation on the following directions: Canadian utility fuel performance; CANDU owner's group fuel programs; AECL advanced fuel program (high burnup fuel behaviour and development); Pu dispositioning (MOX) activities. 1 tab

  1. Canada goose behavior: Fall 1969

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Canada geese use four divisions of the Mark Twin NWR: Louisa, Delair, Cannon, and Calhoun. There was a shortage of cultivated crops, corn and soybeans, on all...

  2. Prevalence of Congenital Malformations

    Directory of Open Access Journals (Sweden)

    Akhavan Karbasi Sedighah

    2009-05-01

    Full Text Available Congenital malformation (CM will begin to emerge as one of the major childhood health problems .Treatment and rehabilitation of children with congenital malformations are costly and complete recovery is usually impossible. The aim of this study was to determine frequency of CM in Yazd central city of the Islamic Republic of Iran to find out if there has been any difference in the rate and types of CM in this area. This descriptive-observational study carried on 4800 births delivered at all maternity hospitals in Yazd from October 2003 to June 2004. Prevalence of CM was 2.83% (2.86 % in male and 2.68 % in female out of the 136 cases 69(51.88% were males and 64 (48.12% were females and 3 with ambiguous genitalia. Positive family history of CM in sibling was in only 6 cases (4.41%.Overall, musculoskeletal (0.83%, central nerv-ous system (0.47% and genital system (0.37% were accounted as the most common. Frequency of CM was more seen in still birth (12.5% as in comparison to live birth (2.71%. There was not statistical difference be-tween prevalence of CM and neonatal's gender, gestational age, birth order and mother's age, drug ingestion, illness and parental consanguinity. In this study the overall prevalence of congenital malformation among the newborn was higher than those previous reported in Iran and determining the causes of this difference needs more extensive studies.

  3. Recent Decrease in the Prevalence of Congenital Heart Defects in Europe

    DEFF Research Database (Denmark)

    Khoshnood, Babak; Loane, Maria; Garne, Ester;

    2013-01-01

    OBJECTIVES: To examine trends in the prevalence of congenital heart defects (CHDs) in Europe and to compare these trends with the recent decrease in the prevalence of CHDs in Canada (Quebec) that was attributed to the policy of mandatory folic acid fortification. STUDY DESIGN: We used data for th...

  4. Difficulties Assessing Multifactor Productivity for Canada

    OpenAIRE

    Michael J. Harper; Nakamura, Alice O.; Lu Zhang

    2012-01-01

    In 2011, Canada's business sector multifactor productivity (MFP) index, as estimated by Statistics Canada, was below that for 1977, a third of a century earlier. Over these years, public policies were enacted to try to improve Canada's productivity. Yet the nation's MFP continued to fall, relative to both the past and Canada's main trading partners. Policymakers and business decision makers need to know whether Canada's MFP statistics accurately reflect the nation's productivity. We argue tha...

  5. Obesity Prevalence Maps

    Science.gov (United States)

    ... Breastfeeding Micronutrient Malnutrition State and Local Programs Adult Obesity Prevalence Maps Recommend on Facebook Tweet Share Compartir Obesity Prevalence in 2015 Varies Across States and Territories ...

  6. Fusion Canada issue 29

    International Nuclear Information System (INIS)

    A short bulletin from the National Fusion Program highlighting in this issue Canada-Europe Accords: 5 year R and D collaboration for the International Thermonuclear Experimental Reactor (ITER) AECL is designated to arrange and implement the Memorandum of Understanding (MOU) and the ITER Engineering Design Activities (EDA) while EUROTAM is responsible for operating Europe's Fusion R and D programs plus MOU and EDA. The MOU includes tokamaks, plasma physics, fusion technology, fusion fuels and other approaches to fusion energy (as alternatives to tokamaks). STOR-M Tokamak was restarted at the University of Saskatchewan following upgrades to the plasma chamber to accommodate the Compact Toroid (CT) injector. The CT injector has a flexible attachment thus allowing for injection angle adjustments. Real-time video images of a single plasma discharge on TdeV showing that as the plasma density increases, in a linear ramp divertor, the plasma contact with the horizontal plate decreases while contact increases with the oblique plate. Damage-resistant diffractive optical elements (DOE) have been developed for Inertial Confinement Fusion (ICF) research by Gentac Inc. and the National Optics Institute, laser beam homogeniser and laser harmonic separator DOE can also be made using the same technology. Studies using TdeV indicate that a divertor will be able to pump helium from the tokamak with a detached-plasma divertor but helium extraction performance must first be improved, presently the deuterium:helium retention radio-indicates that in order to pump enough helium through a fusion reactor, too much deuterium-tritium fuel would be pumped out. 2 fig

  7. Eastern Canada hydrocarbon development

    International Nuclear Information System (INIS)

    Current petroleum industry activities on Canada's east coast, and future potential were discussed. Offshore drilling activity is proceeding in the Jeanne d'Arc Basin, in addition to the Sable and Terra Nova Offshore Energy Projects. Future potential for Newfoundland and Nova Scotia has been estimated at 30 billion BOE and 13 billion BOE respectively. Natural gas potential off Labrador was estimated at 37 Tcf, offshore Newfoundland at 41 Tcf, and offshore Sable Island at 49 Tcf with varying amounts of oil associated with each field. Cumulative industry spending is expected to reach $ 10 billion by the year 2000, and could reach $20 billion by 2005. Prospects for Mobil Oil, number One in discoveries and industry influence, and number Two in acreage among the partners, were reviewed. Some details of the Sable Offshore Energy Project were outlined. The estimated cost of the project is $2 billion. It is expected to be on stream in late 1999 with a total of 27 wells (11 in phase 1). Reserves are estimated at 3.5 TCF or more. Hibernia was on stream in November 1997. Total recoverable reserves at Hibernia are estimated at 750 MMBls. Peak production of 180,000 b/d is expected by 2000-2001. Life expectancy of 20 years is predicted. The Terra Nova project, located 25 miles southeast of Hibernia, was also reviewed. It will be on stream in late 2000 with total reserves of 350-450 MMBls of oil, peak production at 115,000 to 135,000 b/d with a life expectancy of 15 years. 21 figs

  8. SCWR Concept in Canada

    International Nuclear Information System (INIS)

    AECL is designing the Canadian SCWR concept, which has evolved from the well-established pressuretube type CANDU® reactor. The Canadian SCWR is designed to produce electrical energy as the main product, plus process heat, hydrogen, industrial isotopes, and drinking water (through the desalination process) as supplementary products, all within a more compact reactor building. Another potential application of the available co-generated process heat is the extraction and refining of oil sands, which is presently achieved using co-generation with natural gas turbines and process heat. The extraction and upgrading process requires: thermal power to lower the viscosity and extract the oil; electric power for separation and refining equipment; and hydrogen gas for upgrading the oil product prior to transport. A National Program has been established in Canada to support R&D studies for the Canadian SCWR design. It covers key areas of interest (such as thermal hydraulics, safety, materials, and chemistry) to participants in the Generation-IV International Forum (GIF) SCWR designs. Results generated from the program are contributed to the GIF SCWR project management boards (PMBs). For example, heat transfer correlations have been derived using experimental data primarily obtained from fossil-plant related studies (which were started as early as 1930s. Materials and chemistry studies have evolved from operating experience of fossil-fired power plants to a) develop, and perform targeted testing of, materials for key components, in particular in-core reactor components that will be exposed to conditions not encountered in a fossil-fired boiler (such as irradiation and water radiolysis), and b) develop a suitable water chemistry to minimize corrosion and corrosion product transport

  9. Mental Health Services for Individuals with Intellectual Disabilities in Canada: Findings from a National Survey

    Science.gov (United States)

    Lunsky, Y.; Garcin, N.; Morin, D.; Cobigo, V.; Bradley, E.

    2007-01-01

    Background: People with intellectual disabilities are known to have a high prevalence of mental health problems but few studies have considered how such mental health problems are addressed in Canada. The purpose of the present study was to document both the range of mental health services available to individuals with intellectual disabilities…

  10. Seroprevalence of Borrelia burgdorferi, Anaplasma phagocytophilum, Ehrlichia canis, and Dirofilaria immitis among dogs in Canada

    OpenAIRE

    Villeneuve, Alain; Goring, Jonas; Marcotte, Lynne; Overvelde, Sébastien

    2011-01-01

    The seropositivity of dogs to Borrelia burgdorferi, Anaplasma phagocytophilum, and Ehrlichia canis antibodies, and Dirofilaria immitis antigen was assessed in Canada. Borrelia burgdorferi had the highest seroprevalence, while that of Dirofilaria immitis has not changed significantly in the past 20 y. The risk for these vector-borne infectious agents in Canadian dogs is low but widespread with foci of higher prevalence.

  11. Western Canada Sedimentary Basin competitiveness

    International Nuclear Information System (INIS)

    Recent dramatic expansion of the natural gas industry in the Western Canada Sedimentary Basin provided ample proof of the potential of this area for further development of natural gas supply. However, the inherent competitive advantages provided by the Western Canada Sedimentary Basin were said to have been offset by low netback prices resulting in poor producer economics when competitiveness is measured by availability of opportunities to find and develop gas supply at costs low enough to ensure attractive returns. Technology was identified as one of the key elements in improving basin competitiveness, but the greatest potential lies in reduced transportation costs and increased access to North American market centres. 8 figs

  12. Toxicological findings in fatal motor vehicle collisions in ontario, Canada: a one-year study.

    Science.gov (United States)

    Woodall, Karen L; Chow, Betty L C; Lauwers, Albert; Cass, Dan

    2015-05-01

    Drug-impaired driving is a complex area of forensic toxicology due in part to limited data concerning the type of drugs involved and the concentrations detected. This study analyzed toxicological findings in drivers from fatal motor vehicle collisions (FMVCs) in Ontario, Canada, over a one-year period using a standardized protocol. Of the 229 cases included in the study, 56% were positive for alcohol and/or drugs. After alcohol, cannabis was the most frequently encountered substance (27%), followed by benzodiazepines (17%) and antidepressants (17%). There were differences in drugs detected by age but no marked difference in drugs detected between single and multiple FMVC's. Not all drugs detected were considered impairing either due to drug type, concentration or case history. The findings indicate the importance of comprehensive drug testing in FMVCs and highlight the need to consider a variety of factors, in addition to drug type and concentration, when assessing the role of drugs in driving impairment. PMID:25693690

  13. Legalizing and Regulating Marijuana in Canada: Review of Potential Economic, Social, and Health Impacts

    Science.gov (United States)

    Hajizadeh, Mohammad

    2016-01-01

    Notwithstanding a century of prohibition, marijuana is the most widely used illicit substance in Canada. Due to the growing public acceptance of recreational marijuana use and ineffectiveness of the existing control system in Canada, the issue surrounding legalizing this illicit drug has received considerable public and political attentions in recent years. Consequently, the newly elected Liberal Government has formally announced that Canada will introduce legislation in the spring of 2017 to start legalizing and regulating marijuana. This editorial aims to provide a brief overview on potential economic, social, and public health impacts of legal marijuana in Canada. The legalization could increase tax revenue through the taxation levied on marijuana products and could also allow the Government to save citizens’ tax dollars currently being spent on prohibition enforcement. Moreover, legalization could also remove the criminal element from marijuana market and reduce the size of Canada’s black market and its consequences for the society. Nevertheless, it may also lead to some public health problems, including increasing in the uptake of the drug, accidents and injuries. The legalization should be accompanied with comprehensive strategies to keep the drug out of the hands of minors while increasing awareness and knowledge on harmful effects of the drug. In order to get better insights on how to develop an appropriate framework to legalize marijuana, Canada should closely watch the development in the neighboring country, the United States, where some of its states viz, Colorado, Oregon, Washington, and Alaska have already legalized recreational use of marijuana.

  14. 78 FR 16493 - ExxonMobil Canada Energy, Flint Hills Resources Canada, LP, Imperial Oil, NOVA Chemical (Canada...

    Science.gov (United States)

    2013-03-15

    ..., NOVA Chemical (Canada) Ltd., PBF Holding Company LLC, Toledo Refining Company, LLC, Pennzoil-Quaker... Resources Canada, LP, Imperial Oil, NOVA Chemical (Canada) Ltd., PBF Holding Company LLC, Toledo Refining... party must file a notice of intervention or motion to intervene, as appropriate. The Respondent's...

  15. Canada's commitment to nuclear technology

    International Nuclear Information System (INIS)

    This paper gives a broad update on all facets of the Canadian nuclear industry and demonstrates Canada's continuing commitment to nuclear technology. Canada has developed a global leadership position in nuclear technology for power generation, uranium production and isotope supply. This commitment is being further enhanced by successes in international markets with Candu technology, new uranium mine developments in our province of Saskatchewan, and expanding isotope capabilities including the construction of two new production reactors. Korea's economy is benefiting through collaboration with Canada's leading nuclear companies, both in Korea and Canada. These collaborations have the potential to expand considerably with the implementation of the Kyoto Framework Convention on Climate Change and the anticipated increased demand for new nuclear power generation installations in all major global markets. Much has been publicized about the situation surrounding Ontario Hydro Nuclear and its nuclear recovery program. This paper gives the background and highlights the actions within Ontario and Ontario Hydro designed to ensure the long term recovery of all twenty nuclear units in Ontario. The presentation at the conference will bring the audience completely up-to-date on recent events. (author)

  16. Financing Higher Education in Canada.

    Science.gov (United States)

    Association of Universities and Colleges of Canada, Ottawa (Ontario).

    It is the purpose of the committee responsible for this document to study, report, and make recommendations on the financing of universities and colleges of Canada, with particular reference to the decade ending 1975, including: (1) prospective financial requirements of universities and colleges, for operation, research, physical facilities and…

  17. Canada-China power experience

    International Nuclear Information System (INIS)

    International energy opportunities were reviewed, with emphasis on China, and on Canada-China Power Inc., alternatively known as 'Team Canada'. Canada-Chine Power Inc., is a company founded by three of Canada's leading engineering consulting firms, i.e., Monenco AGRA Inc., SNC Lavalin Inc., and Acres International Limited. An office was established in Beijing in January 1994. Other Canadian manufacturers and engineering companies also have been actively pursuing hydro power opportunities in China for several years in view of China's enormous demand for power. It was estimated that by the year 2000, China will install 137 GW of new capacity, and foreign investment will account for approximately a third of the growth. AGRA is working on a 5400 MW thermal plant on Hainan Island, and is in final negotiations with the Yangtze Three Gorges Development Corporation for a management information system for their 18200 MW multi-purpose project. Criteria used by AGRA to identify international opportunities include: (1) a large capital spending program in fields with capabilities, expertise and past experience, (2) access to international funding, (3) competitive Canadian technology, and (4) an acceptable business and cultural climate. In assessing the opportunities, AGRA decided to concentrate on providing technologies in greatest need, such as project management systems, computer engineering and CAD systems, and clean coal technology

  18. The Inuit (Eskimo) of Canada.

    Science.gov (United States)

    Creery, Ian

    This report examines the history of the colonization of Arctic Canada and the efforts of its 25,000 Inuit residents to decolonize themselves. Initial sections outline the origins and early history of the Inuit; characteristics of Inuit culture, family life, and spirituality; the effects of whaling and the fur trade; and the movement of the Inuit…

  19. Canada report on bioenergy 2008

    International Nuclear Information System (INIS)

    Canada is a nation rich in fossil fuel resources. Canada has a large, well-developed forest sector and is one of the world's largest exporters of wood products. Although national bioenergy policies exist, provincial policies regarding forest resources are necessary because 77 per cent of Canada's forests are under provincial jurisdiction. This report presented an update on Canada's bioenergy policy and resources. The report discussed biomass resources such as woody biomass; agricultural residues; and municipal waste. The use of biomass was presented with particular reference to heat and power; biofuels production; pyrolysis oil; wood pellets; and trends in biomass production and consumption. Current biomass users and biomass prices were also examined. Last, the report addressed imports and exports of ethanol, biodiesel, pyrolysis oil, and wood pellets as well as barriers and opportunities to trade. A list of Canadian bioenergy initiatives and programs was also provided. It was concluded that the greatest opportunities for trade are to succeed in research on super-densified pellets; raise ocean shipping capacity to bring down rates; and to establish and entire biomass industry in Newfoundland Labrador. 20 tabs., 8 figs., 1 appendix

  20. Compute Canada: Advancing Computational Research

    International Nuclear Information System (INIS)

    High Performance Computing (HPC) is redefining the way that research is done. Compute Canada's HPC infrastructure provides a national platform that enables Canadian researchers to compete on an international scale, attracts top talent to Canadian universities and broadens the scope of research.

  1. Advancing clean energy technology in Canada

    International Nuclear Information System (INIS)

    This paper discusses the development of clean energy technology in Canada. Energy is a major source of Canadian prosperity. Energy means more to Canada than any other industrialized country. It is the only OECD country with growing oil production. Canada is a stable and secure energy supplier and a major consumer. Promoting clean energy is a priority to make progress in multiple areas.

  2. Fusion Canada issue 32. Final edition

    International Nuclear Information System (INIS)

    Fusion Canada is a bulletin of the National Fusion Program, this is the last edition. Included in this July edition are articles on Funding for Canada's fusion program, Research and Development on TdeV-96 , Divertor Maintenance Robotics and reference listing for Canada's Fusion research and development sites

  3. The prevalence of transmitted resistance to first-generation non-nucleoside reverse transcriptase inhibitors and its potential economic impact in HIV-infected patients.

    Directory of Open Access Journals (Sweden)

    Sonya J Snedecor

    Full Text Available Non-nucleoside reverse transcriptase inhibitor (NNRTI-based highly active antiretroviral therapy (HAART including efavirenz is recommended as a 1(st-line treatment choice in international HIV guidelines, and it is one of the most common components of initial therapy. Resistance to 1(st-generation NNRTIs is found among treated and untreated HIV-infected individuals creating a subpopulation of HIV-infected individuals in whom efavirenz is not fully effective. This analysis reviewed published articles and conference abstracts to examine the prevalence of 1(st-generation NNRTI resistance in Europe, the United States (US, and Canada and to identify published evidence of the economic consequences of resistance. The reported prevalence of NNRTI resistance was generally higher in US/Canada than in Europe and increased in both regions from their introduction in the late 1990s until the early 2000s. The most recent time-based trends suggest that NNRTI-resistance prevalence may be stable or decreasing. These estimates of resistance may be understated as resistance estimates using ultra-sensitive genotypic testing methods, which identify low-frequency mutations undetected by standard testing methods, showed increased prevalence of resistance by more than two-fold. No studies were identified that explicitly investigated the costs of drug resistance. Rather, most studies reported costs of treatment change, failure, or disease progression. Among those studies, annual HIV medical costs of those infected with HIV increased 1 as CD4 cells decreased, driven in part by hospitalization at lower CD4 cell counts; 2 for treatment changes, and 3 for each virologic failure. The possible erosion of efficacy or of therapy choices through resistance transmission or selection, even when present with low frequency, may become a barrier to the use of 1(st-generation NNRTIs and the increased costs associated with regimen failure and disease progression underlie the importance

  4. Drug Facts

    Medline Plus

    Full Text Available ... Why Is It So Hard to Quit Drugs? Effects of Drugs Drug Abuse Hurts Other People Drug Abuse Hurts Families Drug Abuse Hurts Kids Drug Abuse Hurts Unborn Children Drug Abuse Hurts Your Health Drug Abuse Hurts Bodies Drug Abuse Hurts Brains Drug Abuse and Mental ...

  5. Drug addiction and periodontal diseases

    OpenAIRE

    Saini, Gurpreet Kaur; N D Gupta; Prabhat, K. C.

    2013-01-01

    The prevalence of drug addiction is increasing globally. Drug abuse damages many parts of the body such as oral cavity, lungs, liver, brain, heart etc., Addicts suffer from physical, psychological, emotional and behavioral problems. Their nutrition is also compromised. There is certainly an impact of all these factors on the health of periodontium. Dentists should be aware of the effects of drugs while treating the drug addicts. This article correlates the studies done on the impact of abused...

  6. The current status of percutaneous vertebroplasty in Canada

    Energy Technology Data Exchange (ETDEWEB)

    Heffernan, E.J.; O' Sullivan, P.J.; Alkubaidan, F.O.; Heran, M.K.S.; Legiehn, G.M.; Munk, P.L. [Dept. of Radiology, Vancouver General Hospital, Univ. of British Columbia, Vancouver, British Columbia (Canada)], E-mail: ejheffernan@eircom.net

    2008-04-15

    To provide an overview of the current status of percutaneous vertebroplasty (PVP) practice in Canada, including the preprocedure work up operative technique and follow-up practice of physicians performing the procedure in this county. Questionnaires were emailed to 31 institutions performing percutaneous vertebroplasty across Canada. Twenty-three (74.2%) completed surveys were returned, representing data from 1,516 vertebroplasties performed by 66 radiologists and surgeons. Preoperative routine imaging and screening practice varies widely. The majority of respondents perform PVP under conscious sedation; however, an anaesthetist is present in only 22% of institutions. Biplane fluoroscopy is used in 43.5% of practices. The preference for unipedicular or bipedicular injection varies: in 7 institutions, a unipedicular approach is used in at least 80% of cases. Patients receive a follow-up by the screening physician in 65.2% of institutions. There were 4 complications requiring treatment. Venous and intradiscal extravasation rates were 20.8% and 25.3%, respectively; however, the vast majority of these were clinically insignificant. PVP complication rates reported in our Canadian survey compare favourably with those in the published literature. The number of PVPs performed annually in the institutions surveyed appears small, relative to the figures from the United States. The prevalence of osteoporosis and incidence of vertebral compression fractures in Canada is increasing as the population ages, and demand for PVP is likely to rise significantly in the coming years. (author)

  7. Drug Facts

    Medline Plus

    Full Text Available ... Drug Abuse Hurts Kids Drug Abuse Hurts Unborn Children Drug Abuse Hurts Your Health Drug Abuse Hurts ... and Family Can Help Prevent Drug Abuse Help Children and Teens Stay Drug-Free Talking to Kids ...

  8. Drug Facts

    Medline Plus

    Full Text Available ... People Drug Abuse Hurts Families Drug Abuse Hurts Kids Drug Abuse Hurts Unborn Children Drug Abuse Hurts ... Children and Teens Stay Drug-Free Talking to Kids About Drugs: What To Say if You Were ...

  9. Environmental radioactivity in Canada 1986

    International Nuclear Information System (INIS)

    The radiological surveillance program of the Department of National Health and Welfare is conducted for the purpose of determining levels of environmental radioactivity in Canada and assessing the resulting population exposures. During 1986 the program was strongly influenced by radioactive fallout on Canada resulting from the Chernobyl nuclear reactor accident on April 26, 1986 in the Soviet Ukraine. The Environmental Radiation Hazards Division (ERHD) increased its frequency of analyses of environmental samples immediately following the accident. Interim screening limits for foodstuffs were developed. A measurement program for radioactivity in domestic and imported foods was implemented. The ERHD measurement program was supplemented by additional measurements conducted by many other private and government laboratories. Radiation doses to Canadian from Chernobyl fallout were extremely low with no group in the population receiving more than 10 microsieverts

  10. Civil emergency planning in Canada.

    Science.gov (United States)

    Wallace, J F

    1967-01-28

    THE NATIONAL OBJECTIVES OF CIVILIAN EMERGENCY PLANNING ARE: (1) protection and preservation of life and property; (2) maintenance of governmental structure; and (3) conservation of resources. The Canada Emergency Measures Organization (E.M.O.) has been developed to accomplish these objectives. E.M.O. co-ordinates other departments and agencies of federal government and its organization is reflected within provincial and municipal governments.Present E.M.O. accomplishments include: an attack warning system; an emergency broadcasting system; emergency government facilities; 400 emergency measure organizations across Canada; plans to implement general readiness; a medical stockpile; and "shadow agencies" for control of housing, food and manpower.PRESENT UNDERTAKINGS INCLUDE: a national survey of fallout shelters; the equipping of the radiation defence (RADEF); the pre-positioning of the items of the medical stockpile; and the training at the Canadian Emergency Measures College at Arnprior. PMID:6015737

  11. Fusion energy and Canada's role

    International Nuclear Information System (INIS)

    Fusion is the process of releasing energy from matter which occurs in our sun. Canada is contributing to the development of technology which will permit this process to be harnessed and made available on earth. The international effort has increased from a modest beginning in the 1950s to a level of approximately two billion dollars annually in the 1980s. The purpose of this booklet is to introduce the concept of fusion energy as a technology which should make an important addition to the mix of energy sources for our future. Through a co-ordinated approach, Canada has established several projects which will contribute significantly to the development of technologies in specific areas leading to opportunities now for Canadian industry in the international effort

  12. Women in physics in Canada

    Science.gov (United States)

    Xu, Li-Hong; Ghose, Shohini; Milner-Bolotin, Marina; McKenna, Janis; Bhadra, Sampa; Predoi-Cross, Adriana; Dasgupta, Arundhati; Campbell, Melanie; Barkanova, Svetlana; Steinitz, Michael

    2015-12-01

    While the overall climate for women physicists both in academia and industry has improved significantly over the past decade in Canada, it will be some time before women are well represented. Numbers of women in physics at all academic levels have increased, but are less than ideal at the full professor level. Organizations such as the Canadian Association of University Teachers and local initiatives are striving to minimize the socio-economic and professional gaps between women and men. The Canadian Association of Physicists, through its Committee to Encourage Women in Physics, and the Natural Sciences and Engineering Research Council are supportive and serve as catalysts, bringing together men and women to discuss and address issues concerning women in physics across Canada.

  13. Nuclear criticality safety in Canada

    International Nuclear Information System (INIS)

    The approach taken to nuclear criticality safety in Canada has been influenced by the historical development of participants. The roles played by governmental agencies and private industry since the Atomic Energy Control Act was passed into Canadian Law in 1946 are outlined to set the scene for the current situation and directions that may be taken in the future. Nuclear criticality safety puts emphasis on the control of materials called special fissionable material in Canada. A brief account is given of the historical development and philosophy underlying the existing regulations governing special fissionable material. Subsequent events have led to a change in emphasis in the regulatory process that has not yet been fully integrated into Canadian legislation and regulations. Current efforts towards further development of regulations governing the practice of nuclear criticality safety are described. (auth)

  14. Electric power in Canada, 1990

    International Nuclear Information System (INIS)

    This report reviews the structure of the electric power industry in Canada, describes the regulatory structures that are in place, and puts the Canadian electricity industry into an international context. It presents statistics on electricity generation and consumption, imports and exports, transmission, costs and pricing, and financing. It forecasts anticipated energy demands, generating capacity and actual generation, exports, fuel requirements, and expenditures. The impacts of demand-side management and non-utility generation are discussed. (82 tabs., 23 figs.)

  15. Electric power in Canada, 1989

    International Nuclear Information System (INIS)

    This report reviews the structure of the electric power industry in Canada, describes the regulatory structures that are in place, and puts the Canadian electricity industry into an international context. It presents statistics on electricity generation and consumption, imports and exports, transmission, costs and pricing, and financing. It forecasts anticipated energy demands, generating capacity and actual generation, exports, fuel requirements, and expenditures. The impacts of demand-side management and non-utility generation are discussed. (78 tabs., 27 figs.)

  16. Canada: The largest uranium producer

    International Nuclear Information System (INIS)

    Despite all the current difficulties, previous erroneous forecasts and other mistakes, the longer term future looks good for uranium mining and for Canada's industry in particular. Saskatchewan continues to offer the most exciting new prospects, the huge and fabulously high grade Cigar Lake deposits being the most spectacular of the recent discoveries. Notwithstanding continuous mining for 30 years from Elliot Lake there still remain there significant uncommitted reserves which can be developed when the market for uranium is in better balance

  17. The nuclear debate in Canada

    International Nuclear Information System (INIS)

    The author argues that the nuclear debate in Canada is concerned less with the safety of nuclear power plants and more with arguments of economics and social decision-making. The nuclear industry cannot afford to neglect the continuing need to inform the public about nuclear risks. But there is also a need to develop specific arguments to increase public acceptance of nuclear energy as an economic, democratic and equitable energy option

  18. The use of Traditional Medicine by Ghanaians in Canada

    Directory of Open Access Journals (Sweden)

    van Teijlingen Edwin R

    2008-06-01

    Full Text Available Abstract Background Research into health and health-care seeking behaviour amongst immigrant populations suggests that culturally-based behaviours change over time towards those prevalent in the host culture. Such acculturation of immigrant groups occurs as part of the interaction of immigrants with mainstream culture. This study examined the acculturation of Ghanaian immigrants in Greater Toronto Area (Canada focusing particularly on attitudes towards and usage of Ghanaian traditional medicine (TRM. Methods The study used both quantitative and qualitative methods. Structured questionnaire interviews were conducted with a sample of Ghanaians in active collaboration with the Ghanaian-Canadian Association in the Greater Toronto Area (GTA. A total of 512 questionnaire interviews were conducted. In addition, three focus groups of nine participants each were conducted with a sub-sample of Ghanaians in Canada. Results Both the questionnaire and the focus groups indicated that nearly 73% of the Ghanaian immigrants in Canada have a positive attitude toward Ghanaian TRM. This is in comparison with less than 30% who have changed their attitude for various reasons. Some of the attraction of TRM lies in its holistic origin. Ghanaians in the GTA have been pursuing 'integration' and 'assimilation' in their acculturation in Canada. Some have given up or modified some of their attitudes and opinions toward TRM to embrace the 'modern' or 'civilized' way of living. Conclusion There is the need for health care providers and other stakeholders to be aware of the influence of religion on African immigrants during their acculturation process. Although modernity is said to be founded on the 'ruthless undermining of tradition', there is no evidence to suggest that Ghanaian traditional religion has been undermined to such an extent that there is a major change in attitudes towards TRM.

  19. Indigenous Educational Attainment in Canada

    Directory of Open Access Journals (Sweden)

    Catherine E. Gordon

    2014-06-01

    Full Text Available In this article, the educational attainment of Indigenous peoples of working age (25 to 64 years in Canada is examined. This diverse population has typically had lower educational levels than the general population in Canada. Results indicate that, while on the positive side there are a greater number of highly educated Indigenous peoples, there is also a continuing gap between Indigenous and non-Indigenous peoples. Data also indicate that the proportion with less than high school education declined, which corresponds with a rise of those with a PSE; the reverse was true in 1996. Despite these gains, however, the large and increasing absolute numbers of those without a high school education is alarming. There are intra-Indigenous differences: First Nations with Indian Status and the Inuit are not doing as well as non-Status and Métis peoples. Comparisons between the Indigenous and non-Indigenous populations reveal that the documented gap in post-secondary educational attainment is at best stagnant. Out of the data analysis, and based on the history of educational policy, we comment on the current reform proposed by the Government of Canada, announced in February of 2014, and propose several policy recommendations to move educational attainment forward.

  20. Overview of Canada's uranium industry

    International Nuclear Information System (INIS)

    This paper places Canada's uranium industry in its international context. Most uranium, except that produced in the United States, is traded internationally. A brief history of the industry worldwide is given to show how the principal producing areas have fared to date. The industry is young, highly cyclical, and still far from achieving stability. Uranium is a single end-use commodity, entirely dependent on the generation of electricity in nuclear stations, and is without price elasticity: lowering the price does not increase demand. The typical nuclear fuel processing chain has not encouraged or led to much vertical integration. Uranium is subject to more governmental control than any other commodity. The principal market is located in the industrial countries of western Europe, the United States, Canada, and the far east. The uranium supply-demand situation is reviewed, including the current and near-term oversupply and the longer term outlook to 1995. The major negative impact of reactor cancellations and deferments in the United States is discussed. Because of the difficulty in getting reactors on line, it has become easier to forecast the demand for uranium over the next 10 years. It is more difficult to predict how that demand will be met from the more than ample competing sources. Canada's potential for supplying a significant portion of this demand is considered in relation to producers and potential new producers in other countries

  1. Education of pharmacists in Canada.

    Science.gov (United States)

    Austin, Zubin; Ensom, Mary H H

    2008-12-15

    In Canada, the education of pharmacists is built upon a foundation of strong, research-intensive publicly funded universities and a universal health-care system that balances government and private financing for prescription medications. The evolution of pharmacy education and practice in Canada has laid the foundation for a variety of emerging trends related to expanded roles for pharmacists, increasing interprofessional collaboration for patient-centered care, and emergence of pharmacy technicians as a soon-to-be regulated professional group in parts of the country. Current challenges include the need to better integrate internationally educated pharmacists within the domestic workforce and tools to ensure continuous professional development and maintenance of competency of practitioners. Academic pharmacy is currently debating how best to manage the need to enhance the pharmacy curriculum to meet current and future skills needs, and whether a doctor of pharmacy (PharmD) degree ought to become the standard entry-to-practice qualification for pharmacists in Canada. PMID:19325948

  2. Women in Physics in Canada

    Science.gov (United States)

    McKenna, Janis

    2012-10-01

    Here we are in the 21st century in Canada, where most of us would say that young girls and boys have equal access to education, opportunities, and careers of their own choice. In Canada, women currently outnumber men in full-time university enrollment, in Medical Schools and in Law Schools. 48% of the Canadian work force is female, yet women make up only 21% of working professionals in science, engineering and technology. Canada-wide in Physics, the situation is such that only 20% of our BSc graduates are women, and 19% of our PhD graduates are women. It is evident that the ``leaky pipeline'' in Physics leaks most at a young age, before BSc graduation. High school physics statistics in BC indicate that while most of the grade 12 science and math disciplines have roughly equal numbers of young men and women enrolled, this is not the case for high school physics, where province-wide, only 30% of Physics 12 students are women. (Biology is also skewed, but in the other direction: 62% of Biology 12 students are women) This poster will present current statistics and will hopefully be a wake-up call for us all to consider participating in more outreach in science, and especially physics, in our high schools.

  3. Youth and Drugs. Internships in Drug Education: A Feasibility Study.

    Science.gov (United States)

    Cheaney, Lee

    New statistics indicate that drug use is prevalent among today's youth for reasons of alienation, affluency, a philosophy of experimentation, peer pressure of social acceptance, availability of drugs, and changing values. The solution lies not in punitive measures but in education as a practical approach. Although much is being done toward drug…

  4. Drugs in Sport: An Overview.

    Science.gov (United States)

    Ungerleider, Steven

    This literature review addresses the prevalance of drug use and abuse among college athletes and the reasons for such abuse. Among reasons cited are status, peer pressure, boredom, and performance enhancement. Possible interventions that may prevent illegal drug use are also discussed, including educating coaches and trainers to help athletes,…

  5. The Geographic Distribution of Liver Cancer in Canada Does Not Associate with Cyanobacterial Toxin Exposure

    Directory of Open Access Journals (Sweden)

    Meaghan A. Labine

    2015-11-01

    Full Text Available Background: The incidence of liver cancer has been increasing in Canada over the past decade, as has cyanobacterial contamination of Canadian freshwater lakes and drinking water sources. Cyanotoxins released by cyanobacteria have been implicated in the pathogenesis of liver cancer. Objective: To determine whether a geographic association exists between liver cancer and surrogate markers of cyanobacterial contamination of freshwater lakes in Canada. Methods: A negative binomial regression model was employed based on previously identified risk factors for liver cancer. Results: No association existed between the geographic distribution of liver cancer and surrogate markers of cyanobacterial contamination. As predicted, significant associations existed in areas with a high prevalence of hepatitis B virus infection, large immigrant populations and urban residences. Discussion and Conclusions: The results of this study suggest that cyanobacterial contamination of freshwater lakes does not play an important role in the increasing incidence of liver cancer in Canada.

  6. Drug Facts

    Medline Plus

    Full Text Available ... Abuse Hurts Unborn Children Drug Abuse Hurts Your Health Drug Abuse Hurts Bodies Drug Abuse Hurts Brains Drug Abuse and Mental Health Problems Often Happen Together The Link Between Drug ...

  7. Drug Facts

    Medline Plus

    Full Text Available ... Addiction? Addiction Risk Factors Does Addiction Run in Families? Why Is It So Hard to Quit Drugs? ... Drug Abuse Hurts Other People Drug Abuse Hurts Families Drug Abuse Hurts Kids Drug Abuse Hurts Unborn ...

  8. Immigration and Crime: Evidence from Canada

    OpenAIRE

    Zhang, Haimin

    2014-01-01

    There is growing belief in many developed countries, including Canada, that the large influx of the foreign-born population increases crime. Despite the heated public discussion, the immigrant-crime relationship is understudied in the literature. This paper identifies the causal linkages between immigration and crime using panel data constructed from the Uniform Crime Reporting Survey and the master files of the Census of Canada. This paper distinguishes immigrants by their years in Canada an...

  9. Fusion energy. What Canada can do

    International Nuclear Information System (INIS)

    As Canada's fusion programs have grown, Canadian capabilities in fusion science and technology have grown and matured with them. The fusion capabilities described in this booklet have come from a coordinated national effort. The Government of Canada is committed to continuing its fusion energy program, and to supporting global fusion efforts. These first pages provide an overview of Canada's fusion work and its underlying basis of science and technology

  10. Chiropractic radiology in Canada: an anthology of the Chiropractic College of Radiologists (Canada) Inc

    OpenAIRE

    Shrubb, Eric F.

    1990-01-01

    Although there are numerous chiropractic institutions, one which receives little acclaim, but contributes significantly to chiropractic life in Canada, is the Chiropractic College of Radiologists (Canada) Inc. The following presentation represents a brief historical perspective of this most prestigious organization.

  11. Nonmedical Prescription Drug Use among Adolescents: The Influence of Bonds to Family and School

    Science.gov (United States)

    Ford, Jason A.

    2009-01-01

    There has been a tremendous increase in the prevalence of nonmedical prescription drug use among adolescents in recent years. Research now indicates that the prevalence of nonmedical prescription drug use is greater than the prevalence of other illicit drug use, excluding marijuana. Despite these recent trends, there is a dearth of research in the…

  12. Canada Education Savings Program: Annual Statistical Review 2012

    Science.gov (United States)

    Human Resources and Skills Development Canada, 2012

    2012-01-01

    The Canada Education Savings Program (CESP) has been an initiative of the Government of Canada since 1998. As part of the Department of Human Resources and Skills Development Canada, the program administers the Canada Education Savings Grant (CESG) and the Canada Learning Bond (CLB). These two initiatives help Canadian families save for a child's…

  13. Abortion health services in Canada

    Science.gov (United States)

    Norman, Wendy V.; Guilbert, Edith R.; Okpaleke, Christopher; Hayden, Althea S.; Steven Lichtenberg, E.; Paul, Maureen; White, Katharine O’Connell; Jones, Heidi E.

    2016-01-01

    Abstract Objective To determine the location of Canadian abortion services relative to where reproductive-age women reside, and the characteristics of abortion facilities and providers. Design An international survey was adapted for Canadian relevance. Public sources and professional networks were used to identify facilities. The bilingual survey was distributed by mail and e-mail from July to November 2013. Setting Canada. Participants A total of 94 abortion facilities were identified. Main outcome measures The number and location of services were compared with the distribution of reproductive-age women by location of residence. Results We identified 94 Canadian facilities providing abortion in 2012, with 48.9% in Quebec. The response rate was 83.0% (78 of 94). Facilities in every jurisdiction with services responded. In Quebec and British Columbia abortion services are nearly equally present in large urban centres and rural locations throughout the provinces; in other Canadian provinces services are chiefly located in large urban areas. No abortion services were identified in Prince Edward Island. Respondents reported provision of 75 650 abortions in 2012 (including 4.0% by medical abortion). Canadian facilities reported minimal or no harassment, in stark contrast to American facilities that responded to the same survey. Conclusion Access to abortion services varies by region across Canada. Services are not equitably distributed in relation to the regions where reproductive-age women reside. British Columbia and Quebec have demonstrated effective strategies to address disparities. Health policy and service improvements have the potential to address current abortion access inequity in Canada. These measures include improved access to mifepristone for medical abortion; provincial policies to support abortion services; routine abortion training within family medicine residency programs; and increasing the scope of practice for nurses and midwives to include abortion

  14. Landfill gas management in Canada

    International Nuclear Information System (INIS)

    Landfill gas produced from solid waste landfills is one of the most significant sources of anthropogenic methane in Canada. Methane, a potent greenhouse gas, is 24.5 times more powerful than carbon dioxide by weight in terms of global climate change. Landfill gas recovery plays an important role in Canada's commitment to stabilize greenhouse gas emissions at 1990 levels by the year 2000 under the United Nations Framework Convention on Climate Change. Landfill gas is a potentially harmful emission that can be converted into a reliable environmentally-sustainable energy source used to generate electricity, fuel industries and heat buildings. The recovery and utilization of landfill gas is a win-win situation which makes good sense from local, regional and global perspectives. It provides the benefits of (1) reducing the release of greenhouse gases that contribute to global warming; (2) limiting odors; (3) controlling damage to vegetation; (4) reducing risks from explosions, fires and asphyxiation; (5) converting a harmful emission into a reliable energy source; and (6) creating a potential source of revenue and profit. Canadian landfills generate about 1 million tons of methane every year; the equivalent energy of 9 million barrels of oil (eight oil super tankers), or enough energy to meet the annual heating needs of more than half a million Canadian homes. Currently, twenty-seven facilities recover and combust roughly 25% of the methane generated by Canadian landfills producing about 3.2 PJ (1015 Joules) of energy including 80 MW of electricity and direct fuel for nearby facilities (e.g., cement plants, gypsum board manufacturers, recycling facilities, greenhouses). This paper reviews landfill gas characteristics; environmental, health and safety impacts; landfill gas management in Canada; the costs of landfill gas recovery and utilization systems; and on-going projects on landfill gas utilization and flaring

  15. Nuclear waste management in Canada

    International Nuclear Information System (INIS)

    The classification of radioactive wastes in Canada involves two categories - waste of such a nature or in such amounts that it could be hazardous to the public, and waste which can be dealt with safely by methods available to individual institutions having at their disposal only conventional methods for getting rid of unwanted material. It is easy to provide for long-term retention of radioactive wastes if no account need be taken of expense. However, it is unreasonable (and discouraging to progress) to insist upon techniques of waste management that are applicable to multi-curie sources when the amounts to be dealt with are in the millicurie range. (author)

  16. Decommissioning Experience: Chalk River, Canada

    International Nuclear Information System (INIS)

    Full text: Atomic Energy of Canada Limited has reported that work has continued on the decommissioning of old structures on the Chalk River laboratory site. An environmental assessment was approved in 2006 for the decommissioning of the NRX reactor fuel bays (A and B). The regulator approved two work packages for the removal of water and the wooden structure over the bays. The A bays were cleaned as far as possible and were emptied in 2007. Decontamination work will continue. Sections of the B bays were filled with sand and other parts filled with water. NRX is currently in storage (i.e. a dormant state) with surveillance. (author)

  17. Environmental radioactivity in Canada 1987

    International Nuclear Information System (INIS)

    The radiological surveillance program of the Department of National Health and Welfare is conducted for the purpose of determining levels of environmental radioactivity in Canada and assessing the resulting population exposures. A study was initiated to evaluate the contamination by cesium-137, of caribou, a major source of food in northern communities. Work on development of methods proceeded for the determination of radon, carbon-14, polonium-210, radium-228 and isotopic uranium in samples. Monitoring continued of fallout contamination from Chernobyl of imported foods. All measurements made during 1987 are below the limits recommended by the International Commission on Radiological Protection

  18. Environmental radioactivity in Canada - 1982

    International Nuclear Information System (INIS)

    The radiological surveillance program of the Department of National Health and Welfare is conducted for the purpose of determining levels of environmental radioactivity in Canada and assessing the resulting population exposures. Special investigations were carried out during 1982 on metabolism of natural radionuclides and on the accumulation of radon in energy-efficient homes. The pre-operational phase of the monitoring program at the Point Lepreau Nuclear Generating Station was completed. Dose commitments have been estimated for the ongoing natural radioactivity, fallout and reactor studies. All measurements made during the year are below the limits recommended by the International Commission on Radiological Protection

  19. Environmental radioactivity in Canada, 1980

    International Nuclear Information System (INIS)

    The radiological surveillance program of the Department of National Health and Welfare is conducted to determine levels of environmental radioactivity in Canada and asessing the resulting population exposures. In this report, the results for 1980 from the analyses of air, precipitation, water vapour, drinking water, milk, biota and bone for critical radionuclides are presented. The graphical format is used with extensions of the trend-lines to enable identification of changes in the levels and assessment of their potential health significance. All the levels measured during this period are below the permissible limits recommended by the International Commission for Radiological Protection

  20. Canada.

    Science.gov (United States)

    Gilham, Virginia

    1994-01-01

    Annotates 122 publications from the Canadian federal government and from 9 Canadian provinces. Topics include environmental programs and problems, gambling, crime, young offenders, health and welfare issues, use of electronic information, materials on education, employment, tourism, the North American Free Trade Agreement, and issues relating to…

  1. Canada.

    Science.gov (United States)

    Gillham, Virginia

    1992-01-01

    This annotated bibliography lists 110 Canadian federal and provincial government documents published in 1991 that address a wide range of topics, including demographics; constitutional law; social issues, including problems of women, children, and minorities; education; the environment; and standard of living. A list of reviewers is included. (MES)

  2. Drug addiction and periodontal diseases

    Science.gov (United States)

    Saini, Gurpreet Kaur; Gupta, N. D.; Prabhat, K. C.

    2013-01-01

    The prevalence of drug addiction is increasing globally. Drug abuse damages many parts of the body such as oral cavity, lungs, liver, brain, heart etc., Addicts suffer from physical, psychological, emotional and behavioral problems. Their nutrition is also compromised. There is certainly an impact of all these factors on the health of periodontium. Dentists should be aware of the effects of drugs while treating the drug addicts. This article correlates the studies done on the impact of abused drugs such as alcohol, tobacco, opiates, cannabis, amphetamines etc., on general and periodontal health. PMID:24174750

  3. Prevalence of crab asthma in crab plant workers in Newfoundland and Labrador

    OpenAIRE

    Cartier, André; Lehrer, Samuel B.; Horth-Susin, Lise; Swanson, Mark; Neis, Barbara; Howse, Dana; Jong, Michael

    2004-01-01

    Objectives. The aim of the study was to determine the prevalence of snow crab sensitisation and occupational asthma. Study design. Prevalence study of symptoms, pulmonary function testing and allergy testing to crab was conducted in four crab plants of different design in Newfoundland and Labrador, Canada. Methods. Plants workers in four crab plants were interviewed and offered skin testing, RAST, pulmonary function testing and peak flow monitoring before and during crab processing. Results. ...

  4. Drug Facts

    Medline Plus

    Full Text Available ... Health Drug Abuse Hurts Bodies Drug Abuse Hurts Brains Drug Abuse and Mental Health Problems Often Happen Together The Link Between Drug Abuse and HIV/AIDS Recovery & Treatment Drug Treatment Facts Does Drug Treatment Work? Types of Drug Treatment What Is a Relapse? ...

  5. Natural background radiation in Canada

    International Nuclear Information System (INIS)

    Published airborne gamma ray survey data from 33 areas of Canada were used to compile information on the average ground level exposure from natural radiation. The exposures at ground level were calculated from the surface concentrations of potassium, uranium and thorium. The highest levels of radioactivity were found in northern Canada and were generally related to granitic rocks; the lowest levels with the Athabasca sandstone. Summer outdoor exposure rates have a population-weighted average of 3.7 +- 2.3 μR.h-1, of which 48 percent orginated from potassium, 43 percent from the thorium series and 9 percent from the uranium series. This low level of radioactivity, compared to worldwide data, has resulted from erosion of a geologically old continental crust in which radioactivity decreases with depth. When seasonal variations of soil moisture and snow cover are considered, the annual population-weighted average outdoor exposure rate decreases to 2.8 +- 1.7 μR.h-1 corresponding to an annual outdoor dose-equivalent of 150 +- 90 μSV. Factors increasing the annual outdoor dose-equivalent are cosmic radiation (320 +- 30 μSV) and the internal radioactivity of the body (190 μSV). Using the ratio between indoor and outdoor values for worldwide published data, the average annual Canadian whole-body dose-equivalent from all sources of natural radiation is estimated to be 690 +-130 μSV

  6. 2000 Western Canada activity forecast

    International Nuclear Information System (INIS)

    All wells drilled in Western Canada during the first nine months of 1999 are listed and sorted into 12 geographical areas used in the Petroleum Services Association of Canada (PSAC) well cost study. Each area represents wells of common drilling, production and depth characteristics. Area totals for well counts and meters drilled were determined from the sorting process. Previous years' activities are reviewed and various operators and PSAC members contacted to review upcoming programs. In addition, trends and other projections were consulted to develop an estimate of drilling activity for the rest of 1999 as well as a projection of drilling activity for 2000. The historical and projected drilling activities were tabulated and plotted for each area. Average drilling costs for each area were determined, and the total expenditures were calculated for each area by multiplying the the projected meterage by the adjusted drilling costs. All costs were allocated to various services and products utilizing percentages determined in the Well Cost Study. During the sorting process, a list was developed of the major operators in each area, which list is included in the report along with average depths and types of wells drilled by the various operators in each area. The costs included in the report include only drilling and completion operations, starting with the building of the location prior to drilling, and ending with the installation of the wellhead after construction. 5 tabs

  7. 1999 Western Canada activity forecast

    International Nuclear Information System (INIS)

    The forecasts contained in this report are based on a review of the drilling activity through the first eight months of 1998 in twelve geographic areas of Western Canada. The forecasts incorporate current operator activity and trends into an estimate of well counts and meters drilled for the entire year of 1998. The estimates produced in this manner serve as the basis for the activity forecast for 1999. This projection, and cost data developed for the Association's 1998 Well Cost Study released in September 1998, provide the foundation for calculating the anticipated expenditure for various products and services in each of the specified geographical areas. Major operators in each area, and the type of drilling activities conducted by them, are also included. For Western Canada as a whole, a total of 9,885 wells are predicted to be drilled in 1999, at a total expenditure of $3.939 billion. The predicted average well depth will be 1,171 m, at an average cost of $ 219/m

  8. Nuclear emergency preparedness in Canada

    International Nuclear Information System (INIS)

    The preparedness of utilities and government agencies at various levels for dealing with nuclear emergencies occurring at nuclear reactors in Canada is reviewed and assessed. The review is centered on power reactors, but selected research reactors are included also. Emergency planning in the U.S.A., Germany and France, and international recommendations on emergency planning are reviewed to provide background and a basis for comparison. The findings are that Canadians are generally well protected by existing nuclear emergency plans at the electric utility and provincial levels but there are improvements that can be made, mainly at the federal level and in federal-provincial coordination. Ten issues of importance are identified: commitment to nuclear emergency planning by the federal government; division of federal and provincial roles and responsibilities; auditing of nuclear emergency preparedness of all levels of government and of electric utilities; the availability of technical guidance appropriate to Canada; protective action levels for public health and safety; communication with the public; planning and response for the later phases of a nuclear emergency; off-site exercises and training; coordination of international assistance; and emergency planning for research reactors. (L.L.) 79 refs., 2 tabs

  9. Eastern Canada natural gas developments

    International Nuclear Information System (INIS)

    This power point presentation addressed the following topics regarding development of natural gas in eastern Canada: (1) the 18 Tcf of proven natural gas reserves at Sable Island, (2) Canadian markets benefiting from the Maritimes and Northeast Pipeline (M and NP), (3) a 20 year franchise agreement between Enbridge Gas and the government of New Brunswick, (4) the 25 year provincial franchise agreement by Sempra Atlantic Gas, and (5) Sable Island's influence on central Canada. The Sable Offshore Energy Project (SOEP) is now producing about 540,000 MMBtu/day from 6 fields. Plans for Tier 2 expansion are underway. Firm contracts for the M and NP are scheduled to transport gas from the SOEP to markets in Nova Scotia, New Brunswick, Maine and New Hampshire. Sable gas is also a potential supply for the Quebec market. Gaz Metropolitain and Enbridge have proposed to build the Cartier Pipeline from the Quebec/New Brunswick border to Quebec City. It is unlikely that Sable Island supply will directly serve the Ontario market. Canadian customers for Sable gas and M and NP service include pulp and paper companies, oil refineries, power generators and local distribution companies (LDC), with the majority of demand coming form the electric power industry. tabs., figs

  10. Energy in Canada: An overview

    International Nuclear Information System (INIS)

    Recent changes in the North American natural gas industry are discussed, with a focus on how these changes will affect the ability of Alberta and Canadian natural gas supply to meet market growth. These changes include a decline in the merchant role of many of the major interstate pipelines, resulting in a larger number of smaller-sized purchasers for natural gas marketers to deal with; a greater extent of direct purchasing by local distribution companies and large industrial users, combined with a preference for spot sales rather than long-term commitments; direct marketing of uncontracted gas by many producers and brokers; a bidding type of sales process rather than a negotiated process; and price deregulation. It is foreseen that long term security of supply will again become an important factor to North American buyers, and Canada can offer substantial supplies under secure long term contracts. Marketers will have to seek new market targets such as cogeneration plants and the transportation sector. Access to pipeline transport will be one of the major factors in obtaining new markets. The Canada-USA free trade agreement is viewed as a positive development which should help Canadian gas marketers to gain and retain U.S. customers

  11. Outlier populations: individual and social network correlates of solvent-using injection drug users.

    Directory of Open Access Journals (Sweden)

    Souradet Y Shaw

    Full Text Available OBJECTIVE: We previously identified a high prevalence of Hepatitis C (HCV amongst solvent-using injection drug users (S-IDU relative to other injection drug users within the same locality. Here we incorporated social network variables to better characterize some of the behavioural characteristics that may be putting this specific subgroup of IDU at elevated disease risk. METHODS: A cross-sectional survey of at-risk populations was carried out in Winnipeg, Canada in 2009. Individuals reporting any history of injection drug and/or solvent use were included in the study. Associations between subgroup membership, infection with HCV and HIV and individual and social network variables were examined. RESULTS: In relation to other IDU, S-IDU were more likely to be infected with HCV, to report ever having shared a syringe, and to associate with other IDU. They were further differentiated in terms of their self-reported sexual orientation, ethnicity and in the injection drugs typically used. CONCLUSION: Solvent use stands as a proxy measure of numerous other characteristics that put this group of IDU at higher risk of infection. Provision of adequate services to ostracized subpopulations may result in wider population-level benefits.

  12. Hunger and associated harms among injection drug users in an urban Canadian setting

    Directory of Open Access Journals (Sweden)

    Anema Aranka

    2010-08-01

    Full Text Available Abstract Background Food insufficiency is often associated with health risks and adverse outcomes among marginalized populations. However, little is known about correlates of food insufficiency among injection drug users (IDU. Methods We conducted a cross-sectional study to examine the prevalence and correlates of self-reported hunger in a large cohort of IDU in Vancouver, Canada. Food insufficiency was defined as reporting "I am hungry, but don't eat because I can't afford enough food". Logistic regression was used to determine independent socio-demographic and drug-use characteristics associated with food insufficiency. Results Among 1,053 participants, 681 (64.7% reported being hungry and unable to afford enough food. Self-reported hunger was independently associated with: unstable housing (adjusted odds ratio [AOR]: 1.68, 95% confidence interval [CI]: 1.20 - 2.36, spending ≥ $50/day on drugs (AOR: 1.43, 95% CI: 1.06 - 1.91, and symptoms of depression (AOR: 3.32, 95% CI: 2.45 - 4.48. Conclusion These findings suggest that IDU in this setting would likely benefit from interventions that work to improve access to food and social support services, including addiction treatment programs which may reduce the adverse effect of ongoing drug use on hunger.

  13. Drug allergies

    Science.gov (United States)

    Allergic reaction - drug (medication); Drug hypersensitivity; Medication hypersensitivity ... vomiting to life-threatening anaphylaxis . A true drug allergy is caused by a series of chemical steps ...

  14. Survey of Four Decades of Addiction Prevalence Researches in Iran

    Directory of Open Access Journals (Sweden)

    Hamid Sarrami

    2013-07-01

    Full Text Available Objective: The main aim of this research is the survey of addiction and drug abuse and psychotropic drugs prevalence researches which have been done in our country in last decades Method: To do this research all addiction and drug abuse prevalence researches that have been taken place were collected and analyzed. Results: the results of the researches show that the statistics of addiction has been in an oscillation as in 1390, the survey in 15 to 64 years old people (according to 1385 census that is 50 million people, is equal to one million and three hundred thousand and twenty five persons. Conclusion: the results of the four decades of addiction prevalence in Iran show that in according to the size of the threat of drugs and psychotropic drugs and addiction prevalence and also the change of gender, matrimony, age, job and the level of addicts education, less attention has been given to the drug abuse prevalence researches in public, youngsters, students and governmental and governmental non- officials.

  15. Discontinuation of Preventive Drugs in General Practice

    DEFF Research Database (Denmark)

    Andersen, John Sahl; Lindberg, Laura Maria Glahder; Nixon, Michael Simon;

    the most preventive drugs are prescribed in general practice. Special considerations exist in relation to medication of elderly patients. The prevalence of polypharmacy and the subsequent increased risk of side effects and drug interactions is high. Drug-related problems represent the fifth leading...

  16. Canada's forest biomass resources: deriving estimates from Canada's forest inventory

    International Nuclear Information System (INIS)

    A biomass inventory for Canada was undertaken to address the data needs of carbon budget modelers, specifically to provide estimates of above-ground tree components and of non-merchantable trees in Canadian forests. The objective was to produce a national method for converting volume estimates to biomass that was standardized, repeatable across the country, efficient and well documented. Different conversion methods were used for low productivity forests (productivity class 1) and higher productivity forests (productivity class 2). The conversion factors were computed by constructing hypothetical stands for each site, age, species and province combination, and estimating the merchantable volume and all the above-ground biomass components from suitable published equations. This report documents the procedures for deriving the national biomass inventory, and provides illustrative examples of the results. 46 refs., 9 tabs., 5 figs

  17. Professor: Lær af Canada

    DEFF Research Database (Denmark)

    Greve, Carsten

    2013-01-01

    Transportdebatten: En mulig finansiering af fremtidige infrastrukturprojekter kunne være OPP. Danmark bør tage ved lære af erfaringer fra Canada.......Transportdebatten: En mulig finansiering af fremtidige infrastrukturprojekter kunne være OPP. Danmark bør tage ved lære af erfaringer fra Canada....

  18. Canada Experientially: Every Trail Has a Story.

    Science.gov (United States)

    Henderson, Bob

    The discovery of Canada means rolling out a new map, giving meaning to the land and its heritage. Experientially discovering Canada is at the heart of teaching and learning. It is necessary to balance experiential exploration with classroom and library exploration. In order to achieve this, the student must be a traveler. Programs that attempt to…

  19. AECL: 60 years of contributing to Canada

    International Nuclear Information System (INIS)

    This paper traces the history of the Atomic Energy of Canada Limited. For 60 years AECL has contributed world class science and technology to Canada, while assisting Government on policy issues, enabling business innovation and technology transfer, and generating highly qualified workforce for Canadian industry.

  20. Open Educational Resources in Canada 2015

    Science.gov (United States)

    McGreal, Rory; Anderson, Terry; Conrad, Dianne

    2015-01-01

    Canada's important areas of expertise in open educational resources (OER) are beginning to be built upon or replicated more broadly in all education and training sectors. This paper provides an overview of the state of the art in OER initiatives and open higher education in general in Canada, providing insights into what is happening nationally…

  1. Increased risk for hepatitis C associated with solvent use among Canadian Aboriginal injection drug users

    Directory of Open Access Journals (Sweden)

    Jolly Ann M

    2010-07-01

    Full Text Available Abstract Background Solvent abuse is a particularly serious issue affecting Aboriginal people. Here we examine the association between solvent use and socio-demographic variables, drug-related risk factors, and pathogen prevalence in Aboriginal injection drug users (IDU in Manitoba, Canada. Methods Data originated from a cross-sectional survey of IDU from December 2003 to September 2004. Associations between solvent use and variables of interest were assessed by multiple logistic regression. Results A total of 266 Aboriginal IDU were included in the analysis of which 44 self-reported recent solvent use. Hepatitis C infection was 81% in solvent-users, compared to 55% in those reporting no solvent use. In multivariable models, solvent-users were younger and more likely to be infected with hepatitis C (AOR: 3.5; 95%CI: 1.3,14.7, to have shared needles in the last six months (AOR: 2.6; 95%CI:1.0,6.8, and to have injected talwin & Ritalin (AOR: 10.0; 95%CI: 3.8,26.3. Interpretation High hepatitis C prevalence, even after controlling for risky injection practices, suggests that solvent users may form closed networks of higher risk even amongst an already high-risk IDU population. Understanding the social-epidemiological context of initiation and maintenance of solvent use is necessary to address the inherent inequalities encountered by this subpopulation of substance users, and may inform prevention strategies for other marginalized populations.

  2. DRUGS IN SPORT

    Directory of Open Access Journals (Sweden)

    David R. Mottram

    2005-12-01

    Full Text Available This new edition includes fresh information regarding drugs use and abuse in sport and the updated worldwide anti-doping laws, and changes to the prohibited and therapeutic use exemption lists. The objectives of the book are to review/discuss the latest information on drugs in sport by considering i actions of drugs and hormones, ii medication and nutritional supplements in sport, iii the latest doping control regulations of the WADA, iv the use of banned therapeutic drugs in sport, v an assessment of the prevalence of drug taking in sport. FEATURES A common, uniform strategy and evidence-based approach to organizing and interpreting the literature is used in all chapters. This textbook is composed of twelve parts with sub-sections in all of them. The topics of the parts are: i An introduction to drugs and their use in sport, ii Drug use and abuse in sport, iii Central nervous system stimulants, iv WADA regulations in relation to drugs used in the treatment of respiratory tract disorders, v Androgenic anabolic steroids, vi Peptide and glycoprotein hormones and sport, vii Blood boosting and sport, viii Drug treatment of inflammation in sports injuries, ix Alcohol, anti-anxiety drugs and sport, x Creatine, xi Doping control and sport, xii Prevalence of drug misuse in sport. Each specific chapter has been systematically developed from the data available in prospective, retrospective, case-control, and cross-sectional studies. The tables and figures are numerous, helpful and very useful. AUDIENCE The book provides a very useful resource for students on sports related courses, coaches and trainers, researchers, nutritionists, exercise physiologists, pharmacologists, healthcare professionals in the fields of sports medicine and those involved in the management and administration side of sport. The readers are going to discover that this is an excellent reference book. Extensively revised new edition of this book is also a first-rate resource for

  3. Resistance patterns, prevalence, and predictors of fluoroquinolones resistance in multidrug resistant tuberculosis patients

    OpenAIRE

    Nafees Ahmad; Arshad Javaid; Syed Azhar Syed Sulaiman; Long Chiau Ming; Izaz Ahmad; Amer Hayat Khan

    2016-01-01

    Abstract Background Fluoroquinolones are the backbone of multidrug resistant tuberculosis treatment regimens. Despite the high burden of multidrug resistant tuberculosis in the country, little is known about drug resistance patterns, prevalence, and predictors of fluoroquinolones resistance among multidrug resistant tuberculosis patients from Pakistan. Objective To evaluate drug resistance patterns, prevalence, and predictors of fluoroquinolones resistance in multidrug resistant tuberculosi...

  4. Anabolic-Androgenic Steroids: Prevalence, Knowledge, and Attitudes in Junior and Senior High School Students.

    Science.gov (United States)

    Luetkemeier, Maurie J.; And Others

    1995-01-01

    Reports a survey of junior and senior high school students that investigated the prevalence of anabolic-androgenic steroid use and examined gender, sports participation, and illicit drug use. Results indicated the prevalence of steroid use was 3.3%. Steroid use was greater for males, users of other drugs, and strength trainers. (SM)

  5. A survey of the prevalence of Giardia in dogs presented to Canadian veterinary practices.

    OpenAIRE

    Jacobs, S R; Forrester, C P; Yang, J

    2001-01-01

    Fecal samples (1216) were collected from dogs presented to 15 veterinary practices across Canada and tested for Giardia by ELISA for group-specific antigen. If positive, the presence of Giardia was confirmed by microscopy. Eighty-eight submissions tested positive by ELISA and microscopy. The overall prevalence rate of Giardia was 7.2%.

  6. Prevalência e fatores associados ao uso de antiinflamatórios não-esteróides por pacientes submetidos a endoscopia digestiva alta, Belo Horizonte, Minas Gerais, 2000 Prevalence of and factors associated with nonsteroidal anti-inflammatory drug use by patients submitted to upper endoscopy, Belo Horizonte, Minas Gerais, 2000

    OpenAIRE

    Andréia Queiroz Ribeiro; Gil Sevalho; Cibele Comini César

    2005-01-01

    OBJETIVO: Determinar a prevalência e os fatores associados ao uso de AINE por pacientes submetidos a endoscopia digestiva alta no Hospital das Clínicas da UFMG. MÉTODOS: Estudo transversal de uma amostra de 533 pacientes com idade igual ou superior a 17 anos, com endoscopia previamente marcada na Seção de Endoscopia do Hospital das Clínicas da Universidade Federal de Minas Gerais. Os dados foram coletados por meio de entrevistas. Foram considerados quatro grupos de variáveis exploratórias: so...

  7. Drug Facts

    Science.gov (United States)

    ... text to you. This web site talks about drug abuse, addiction and treatment. Watch Videos Information About Drugs Alcohol ... of the drug. "Max" was addicted to prescription drugs. The addiction slowly took over his life. I need different ...

  8. Generic Drugs

    Science.gov (United States)

    ... name drug. A brand- name drug has a patent. When the patent runs out— usually after 10 to 14 years— ... if you do not have drug coverage. Condition Diabetes Heart failure High cholesterol Migraine Brand-name drug ...

  9. Do Drugs Reduce Utilisation of Other Healthcare Resources?

    OpenAIRE

    Pierre-Yves Cremieux; Pierre Ouellette; Patrick Petit

    2007-01-01

    Background: Drug expenditures per capita have drastically increased over the last quarter century in Canada, with a share of overall healthcare costs rising from 8.8% in 1980 to 16.8% in 2002. Pressure to curb expenditure on drugs has increased accordingly, but containing drug expenditure might increase costs elsewhere in the healthcare sector. Objective: To measure substitution patterns between drugs and other healthcare resources over the last 25 years and thus assess whether containing dru...

  10. Short Communication: Emerging Transmitted HIV Type 1 Drug Resistance Mutations Among Patients Prior to Start of First-Line Antiretroviral Therapy in Middle and Low Prevalence Sites in China

    OpenAIRE

    Wang, Xia; He, Cui; Xing, Hui; Liao, Lingjie; Xu, XiaoQin; He, Jianmei; Liu, Yong; Ling, Hua; Liang, Shu; Jenny H. Hsi; Ruan, Yuhua; Shao, Yiming

    2012-01-01

    It is known that transmitted drug resistance (TDR) will most likely emerge in regions where antiretroviral therapy (ART) has been widely available for years. However, after a decade of rapid scale-up of ART in China, there are few data regarding TDR among HIV-infected patients prior to initiating first-line ART in China. A prospective, observational cohort study was performed at sentinel sites in five provinces or municipalities. Study participants were recruited at the county- or city-level ...

  11. Quality of Artemisinin-Based Combination Formulations for Malaria Treatment: Prevalence and Risk Factors for Poor Quality Medicines in Public Facilities and Private Sector Drug Outlets in Enugu, Nigeria

    OpenAIRE

    Harparkash Kaur; Elizabeth Louise Allan; Ibrahim Mamadu; Zoe Hall; Ogochukwu Ibe; Mohamed El Sherbiny; Albert van Wyk; Shunmay Yeung; Isabel Swamidoss; Green, Michael D.; Prabha Dwivedi; Maria Julia Culzoni; Siân Clarke; David Schellenberg; Fernández, Facundo M.

    2015-01-01

    Background Artemisinin-based combination therapies are recommended by the World Health Organisation (WHO) as first-line treatment for Plasmodium falciparum malaria, yet medication must be of good quality for efficacious treatment. A recent meta-analysis reported 35% (796/2,296) of antimalarial drug samples from 21 Sub-Saharan African countries, purchased from outlets predominantly using convenience sampling, failed chemical content analysis. We used three sampling strategies to purchase artem...

  12. An Observational Study to Evaluate the Prevalence of Erectile Dysfunction (ED) and Prescribing Pattern of Drugs in Patients with ED Visiting an Andrology Specialty Clinic, Mumbai: 2012-14

    Science.gov (United States)

    Kulkarni, Vijay R.; Bhagat, Sagar B.; Beldar, Amit S.; Patel, Sadiq B.

    2015-01-01

    Introduction: Erectile dysfunction (ED) is a common occurrence and its incidence is expected to increase significantly along with the increase in various lifestyle diseases. The drug utilization for ED is very low. Also, studies describing the prescription pattern in ED are lacking. Materials and Methods: We conducted a retrospective cross-sectional observational study, including a drug utilization analysis, of 606 prescriptions as per the standard guidelines (WHO and STROBE). Results: Out of 606, 249 (41%) were from the age group of 30-39 years. Addictions were present in 388 (64%). Out of 606, 186 had urological, 154 had cardiovascular and 102 had psychological co-morbid disorders. Out of 348, 201 were prescribed Tadalafil (low dose) on a once daily basis. Out of 172, 121 were prescribed Sildenafil (high dose) on an ‘as and when required’ basis. Nutritional/ herbal supplements were prescribed in 126/606. The ratio of ‘Prescribed Daily Dose’ to ‘Defined Daily Dose’ of Tadalafil, Sildenafil, and Dapoxetine were 1.1, 1.3 and 1.5 respectively. Conclusion: Measures for de-addiction play an important role in the overall management of ED. The most common co-morbid disorders were urological, like BPH, LUTS, etc, followed by cardiovascular, psychological and diabetes. Overall, rational pharmacotherapy was observed. Tadalafil was the most commonly prescribed drug for ED. The main factor in the selection of a particular PDE5 inhibitor was its pharmacokinetics and cost. Udenafil, being the costliest, was the least prescribed. Dapoxetine was used in a significant number of individuals primarily for PE with ED. The combination of Papaverine, Chlorpromazine ± Alprostadil was used as intracavernosal injection in patients not responding to oral drugs. PMID:26393163

  13. The characteristics of psychiatrists disciplined by professional colleges in Canada.

    Directory of Open Access Journals (Sweden)

    Asim Alam

    Full Text Available BACKGROUND: The identification of health care professionals who are incompetent, impaired, exploitative or have criminal intent is important for public safety. It is unclear whether psychiatrists are more likely to commit medical misconduct offences than non-psychiatrists, and if the nature of these offences is different. AIM: The aim of this study was to compare the characteristics of psychiatrists disciplined in Canada and the nature of their offences and disciplinary sentences for the ten years from 2000 through 2009 to other physicians disciplined during that timeframe. METHODS: Utilizing a retrospective cohort design, we constructed a database of all physicians disciplined by provincial licensing authorities in Canada for the ten years from 2000 through 2009. Demographic variables and information on type of misconduct violation and penalty imposed were also collected for each physician disciplined. We compared psychiatrists to non-psychiatrists for the various outcomes. RESULTS: There were 82 (14% psychiatrists of 606 physicians disciplined in Canada in the ten years from 2000 through 2009, double the national proportion of psychiatrists. Of those disciplined psychiatrists, 8 (9.6% were women compared to 29% in the national cohort. A total of 5 (6% psychiatrists committed at least two separate offenses, accounting for approximately 11% of the total violations. A higher proportion of psychiatrists were disciplined for sexual misconduct (OR 3.62 [95% Confidence Interval [CI] 2.45-5.34], fraudulent behavior (OR 2.32 [95% CI 1.20-4.40] and unprofessional conduct (OR 3.1 [95% CI 1.95-4.95]. As a result, psychiatrists had between 1.85-4.35 greater risk of having disciplinary penalties in almost all categories in comparison to other physicians. CONCLUSION: Psychiatrists differ from non-psychiatrist physicians in the prevalence and nature of medical misconduct. Efforts to decrease medical misconduct by psychiatrists need to be conducted and

  14. A qualitative exploration of prescription opioid injection among street-based drug users in Toronto: behaviours, preferences and drug availability

    OpenAIRE

    Firestone Michelle; Fischer Benedikt

    2008-01-01

    Abstract Background There is evidence of a high prevalence of prescription opioid (PO) and crack use among street drug users in Toronto. The purpose of this qualitative study was to describe drug use behaviours and preferences as well as the social and environmental context surrounding the use of these drugs among young and old street-based drug injection drug users (IDUs). Methods In-depth interviews were conducted with 25 PO injectors. Topics covered included drug use history, types of drug...

  15. Oil price uncertainty in Canada

    Energy Technology Data Exchange (ETDEWEB)

    Elder, John [Department of Finance and Real Estate, 1272 Campus Delivery, Colorado State University, Fort Collins, CO 80523 (United States); Serletis, Apostolos [Department of Economics, University of Calgary, Calgary, Alberta (Canada)

    2009-11-15

    Bernanke [Bernanke, Ben S. Irreversibility, uncertainty, and cyclical investment. Quarterly Journal of Economics 98 (1983), 85-106.] shows how uncertainty about energy prices may induce optimizing firms to postpone investment decisions, thereby leading to a decline in aggregate output. Elder and Serletis [Elder, John and Serletis, Apostolos. Oil price uncertainty.] find empirical evidence that uncertainty about oil prices has tended to depress investment in the United States. In this paper we assess the robustness of these results by investigating the effects of oil price uncertainty in Canada. Our results are remarkably similar to existing results for the United States, providing additional evidence that uncertainty about oil prices may provide another explanation for why the sharp oil price declines of 1985 failed to produce rapid output growth. Impulse-response analysis suggests that uncertainty about oil prices may tend to reinforce the negative response of output to positive oil shocks. (author)

  16. 1999 Western Canada activity forecast

    International Nuclear Information System (INIS)

    Oil and gas drilling activity for the final quarter of 1998 and the first quarter of 1999 for 12 specific geographical areas in Western Canada is reviewed. Each area represents wells of common drilling, production and depth characteristics. Current operator activity and trends are incorporated into an estimate of well counts for 1999. Average drilling costs for each area are also calculated. Drilling of about 8920 wells is projected for 1999. The anticipated drilling and completion expenditures will be about $3.2 (Cdn) billion. While horizontal drilling activity appears to have decreased slightly in 1998, an increase to over 1200 horizontal and directionally drilled wells is projected for 1999. A list of the major operators in each geographical area is also provided. 8 tabs., 3 figs

  17. Oil price uncertainty in Canada

    International Nuclear Information System (INIS)

    Bernanke [Bernanke, Ben S. Irreversibility, uncertainty, and cyclical investment. Quarterly Journal of Economics 98 (1983), 85-106.] shows how uncertainty about energy prices may induce optimizing firms to postpone investment decisions, thereby leading to a decline in aggregate output. Elder and Serletis [Elder, John and Serletis, Apostolos. Oil price uncertainty.] find empirical evidence that uncertainty about oil prices has tended to depress investment in the United States. In this paper we assess the robustness of these results by investigating the effects of oil price uncertainty in Canada. Our results are remarkably similar to existing results for the United States, providing additional evidence that uncertainty about oil prices may provide another explanation for why the sharp oil price declines of 1985 failed to produce rapid output growth. Impulse-response analysis suggests that uncertainty about oil prices may tend to reinforce the negative response of output to positive oil shocks. (author)

  18. Environmental radioactivity in Canada 1988

    International Nuclear Information System (INIS)

    The radiological surveillance program of the Department of National Health and Welfare is conducted for the purpose of determining levels of environmental radioactivity in Canada and assessing the resulting population exposures. Following major changes to the CAMECO Port Hope operations to reduce uranium emissions, a study was initiated to measure uranium levels in air in the community. Studies continued on lung cancer and domestic exposure to radon, and current levels of cesium-137 in caribou, a major source of food in northern communities. The movement of tritium on the Ottawa and St. Lawrence rivers was studied following an accidental release into the Ottawa River. Monitoring continued of fallout contamination from Chernobyl in imported foods. All measurements recorded during 1988 were below the limits recommended by the International Commission on Radiological Protection. (14 refs., 14 figs., 15 tabs.)

  19. Beyond design basis in Canada

    International Nuclear Information System (INIS)

    In response to the Fukushima Daiichi accident, the Canadian Government required: — Ongoing environmental monitoring on Canadian territory from coast to coast. — Deployment of experts to the IAEA. —Issuance of a directive pursuant to the regulatory requirements to all major nuclear facilities to review initial lessons learned. — Re-examination of the safety cases with a focus on: ● External hazards and measures to prevent or mitigate severe accidents; ● Emergency preparedness; ● Implementation of immediate short term and long term measures. At the regulatory level, the CNSC carried out reviews of the safety status of the plants in Canada and abroad. The CNSC site staff carried out focused inspection on seismic, fire, flooding, backup power, hydrogen igniters and passive recombiners, in addition to ongoing inspections against external hazards. The CNSC conducted inspections of spent fuel bays, their components and equipment, heat sinks and alarms, as well as the availability of on-site and off-site resources

  20. How Can Health System Efficiency Be Improved in Canada?

    Science.gov (United States)

    Allin, Sara; Veillard, Jeremy; Wang, Li; Grignon, Michel

    2015-08-01

    Improving value for money in the health system is an often-stated policy goal. This study is the first to systematically measure the efficiency of health regions in Canada in producing health gains with their available resources, and to identify the factors that are associated with increased efficiency. Based on the objective elicited from decision-makers that the health system should ensure access to care for Canadians when they need it, we measured the efficiency with which regions reduce causes of death that are amenable to healthcare interventions using a linear programming approach (data envelopment analysis). Variations in efficiency were explained in part by public health factors, such as the prevalence of obesity and smoking in the population; in part by characteristics of the population, such as their average income; and in part by managerial factors, such as hospital readmissions. PMID:26571467

  1. Drug Facts

    Medline Plus

    Full Text Available ... Drug Abuse Hurts Other People Drug Abuse Hurts Families Drug Abuse Hurts Kids Drug Abuse Hurts Unborn Children ... a Relapse? Find Treatment/Rehab Resources Friends and Family Can Help Prevent Drug Abuse Help Children and Teens Stay Drug-Free ...

  2. The Life Time Prevalence of Childhood Seizure

    Directory of Open Access Journals (Sweden)

    P AlizadehTaheri

    2009-03-01

    Full Text Available "nBackground: Seizure is the most common pediatric neurologic disorder. Epidemiological studies of childhood epilepsy are of importance to compare incidence and prevalence rates, age distribution, inheritance, seizure types, epilepsy syn­dromes and treatment strategies. Since there is little information about prevalence of childhood seizure in Iran, this study was aimed to determine the life time prevalence of childhood seizure and some of its determining factors in Tehran, Iran."nMethods: In this cross sectional study, 2500 male and female students, aged 12 years or younger, studying in fifth grade of primary schools in district one of Ministry of Education were assessed by filling a preliminary questionnaire. Those who were categorized by the author as having a history of any form of seizure were assessed by a second questionnaire. The clinical form of seizure, the presumptive cause, positive family history and use of anti-convulsant drugs were recorded."nResults: The life time prevalence of seizure was 32/1000 population which was more prevalent in boys .Generalized seizure was the most common clinical form. Approximately 60% of cases reported febrile convulsion as the presumptive cause stated by the physician. Positive family history was reported in 29.6% of cases. Anti epileptic drugs were taken by 54% of students with a positive history of seizure."nConclusion: The results of this study show that the life time prevalence of seizure is relatively high in Iranian community, although the other factors were in concordance with other communities.

  3. Prescription and Over-the-Counter Drug Abuse Prevention. Prevention Update

    Science.gov (United States)

    Higher Education Center for Alcohol, Drug Abuse, and Violence Prevention, 2010

    2010-01-01

    According to the White House Office of National Drug Control Policy, "abuse of prescription drugs to get high has become increasingly prevalent among teens and young adults. Past year abuse of prescription pain killers now ranks second--only behind marijuana--as the Nation's most prevalent illegal drug problem." Use of prescription drugs without a…

  4. Prevalence of hepatitis C virus and HIV infection among injection drug users in two Mexican cities bordering the U.S Prevalencia de los virus de la hepatitis C y de la inmunodeficiencia humana entre usuarios de drogas intravenosas, en dos ciudades mexicanas fronterizas con los Estados Unidos de America

    Directory of Open Access Journals (Sweden)

    Emily Faye White

    2007-06-01

    Full Text Available OBJECTIVE: To estimate the prevalence of the hepatitis C virus (HCV and HIV infection and associated risk behaviors among injection drug users (IDUs in two northern Mexican cities. MATERIAL AND METHODS: Between February and April 2005, IDUs were recruited in Tijuana (N=222 and Ciudad Juarez (N=206 using respondent-driven sampling (RDS, a chain referral sampling approach. Interviewer-administered questionnaires assessed drug-using behaviors during the prior six months. Venous blood was collected for immunoassays to detect HIV and HCV antibodies. For HIV, Western blot or immunofluorescence assay was used for confirmatory testing. Final HCV antibody prevalence was estimated using RDS adjustments. RESULTS: Overall, HCV and HIV prevalence was 96.0% and 2.8%, respectively, and was similar in both cities. Most IDUs (87.5% reported passing on their used injection equipment to others, and 85.9% had received used equipment from others. CONCLUSIONS: HIV prevalence was relatively high given the prevalence of HIV in the general population, and HCV prevalence was extremely high among IDUs in Tijuana and Ciudad Juarez. Frequent sharing practices indicate a high potential for continued transmission for both infections. HCV counseling and testing for IDUs in Mexico and interventions to reduce sharing of injection equipment are needed.OBJETIVO: Estimar las prevalencias de los virus de hepatitis C (VHC y de VIH y los comportamientos de riesgo asociados con ellos, entre usuarios de drogas inyectables (UDI en dos ciudades del norte de México. MATERIAL Y MÉTODOS: Entre febrero y abril de 2005, se reclutaron UDIs en Tijuana (N=222 y en Ciudad Juárez (N=206, mediante un método de muestreo llamado en inglés "respondent-driven sampling" (RDS, lo cual es un sistema basado en cadenas de referencia. Los participantes contestaron una encuesta aplicada por entrevista, la cual indagó acerca de los comportamientos en el uso de drogas durante los seis meses previos. Una

  5. National Survey on Drug Use and Health (NSDUH), 2012

    Data.gov (United States)

    U.S. Department of Health & Human Services — The National Survey on Drug Use and Health (NSDUH) series (formerly titled National Household Survey on Drug Abuse) primarily measures the prevalence and correlates...

  6. National Survey on Drug Use and Health (NSDUH), 2009

    Data.gov (United States)

    U.S. Department of Health & Human Services — The National Survey on Drug Use and Health (NSDUH) series (formerly titled National Household Survey on Drug Abuse) primarily measures the prevalence and correlates...

  7. National Survey on Drug Use and Health (NSDUH), 2002

    Data.gov (United States)

    U.S. Department of Health & Human Services — The National Survey on Drug Use and Health (NSDUH) series (formerly titled National Household Survey on Drug Abuse) primarily measures the prevalence and correlates...

  8. National Survey on Drug Use and Health (NSDUH), 2011

    Data.gov (United States)

    U.S. Department of Health & Human Services — The National Survey on Drug Use and Health (NSDUH) series (formerly titled National Household Survey on Drug Abuse) primarily measures the prevalence and correlates...

  9. National Survey on Drug Use and Health (NSDUH), 2004

    Data.gov (United States)

    U.S. Department of Health & Human Services — The National Survey on Drug Use and Health (NSDUH) series (formerly titled National Household Survey on Drug Abuse) primarily measures the prevalence and correlates...

  10. National Survey on Drug Use and Health (NSDUH), 2008

    Data.gov (United States)

    U.S. Department of Health & Human Services — The National Survey on Drug Use and Health (NSDUH) series (formerly titled National Household Survey on Drug Abuse) primarily measures the prevalence and correlates...

  11. National Survey on Drug Use and Health (NSDUH), 2003

    Data.gov (United States)

    U.S. Department of Health & Human Services — The National Survey on Drug Use and Health (NSDUH) series (formerly titled National Household Survey on Drug Abuse) primarily measures the prevalence and correlates...

  12. National Survey on Drug Use and Health (NSDUH), 2010

    Data.gov (United States)

    U.S. Department of Health & Human Services — The National Survey on Drug Use and Health (NSDUH) series (formerly titled National Household Survey on Drug Abuse) primarily measures the prevalence and correlates...

  13. National Survey on Drug Use and Health (NSDUH), 2005

    Data.gov (United States)

    U.S. Department of Health & Human Services — The National Survey on Drug Use and Health (NSDUH) series (formerly titled National Household Survey on Drug Abuse) primarily measures the prevalence and correlates...

  14. National Survey on Drug Use and Health (NSDUH), 2006

    Data.gov (United States)

    U.S. Department of Health & Human Services — The National Survey on Drug Use and Health (NSDUH) series (formerly titled National Household Survey on Drug Abuse) primarily measures the prevalence and correlates...

  15. Drug-induced pancreatitis.

    Science.gov (United States)

    Nitsche, Claudia; Maertin, Sandrina; Scheiber, Jonas; Ritter, Christoph A; Lerch, Markus M; Mayerle, Julia

    2012-04-01

    Drugs are thought to be a rare cause for acute pancreatitis; however 525 different drugs are listed in the World Health Organization (WHO) database suspected to cause acute pancreatitis as a side effect. Many of them are widely used to treat highly prevalent diseases. The true incidence is not entirely clear since only few systematic population based studies exist. The majority of the available data are derived from case reports or case control studies. Furthermore, the causality for many of these drugs remains elusive and for only 31 of these 525 dugs a definite causality was established. Definite proof for causality is defined by the WHO classification if symptoms reoccur upon rechallenge.In the actual algorithm the diagnosis is confirmed if no other cause of acute pancreatitis can be detected, and the patient is taking one of the suspected drugs. PMID:22314811

  16. Canada's nuclear non-proliferation policy

    International Nuclear Information System (INIS)

    Canada's non-proliferation and safeguards policy has two objectives: 1) to promote the emergence of a more effective and comprehensive international non-proliferation regime; and 2) to assure the Canadian people and the international community that Canadian nuclear exports will not be used for any nuclear explosive purpose. By emphasizing the key role of the NPT, by promoting reliance upon and improvements in the IAEA safeguards system, by treating nuclear weapon and non-nuclear weapon states alike regarding Canadian nuclear exports, by working for new approaches covering the sensitive phases (e.g. reprocessing) of the nuclear fuel cycle, Canada's policy promotes attainment of the first objective. The latter objective is served through the network of bilateral nuclear agreements that Canada has put into place with its nuclear partners. Those agreements provide assurance that Canada's nuclear exports are used solely for legitimate, peaceful, nuclear energy production purposes. At the same time, Canada, having formulated its non-proliferation and safeguards policy during the period 1945 to 1980, has recognized that it has gone as far as it can on its own in this field and that from this point on any further changes should be made on the basis of international agreement. The Canadian objective in post-INFCE forums such as the Committee on Assurances of Supply is to exert Canada's best efforts to persuade the international community to devise a more effective and comprehensive international non-proliferation regime into which Canada and other suppliers might subsume their national requirements

  17. Uranium in Canada: Billion-dollar industry

    International Nuclear Information System (INIS)

    In 1988, Canada maintained its position as the world's leading producer and exporter of uranium; five primary uranium producers reported concentrate output containing 12,400 MT of uranium, or about one-third of Western production. Uranium shipments made by these producers in 1988 exceeded 13,200 MT, worth Canadian $1.1 billion. Because domestic requirements represent only 15% of current Canadian output, most of Canada's uranium production is available for export. Despite continued market uncertainty in 1988, Canada's uranium producers signed new sales contracts for some 14,000 MT, twice the 1987 level. About 90% of this new volume is with the US, now Canada's major uranium customer. The recent implementation of the Canada/US Free Trade agreement brings benefits to both countries; the uranium industries in each can now develop in an orderly, free market. Canada's uranium industry was restructured and consolidated in 1988 through merger and acquisition; three new uranium projects advanced significantly. Canada's new policy on nonresident ownership in the uranium mining sector, designed to encourage both Canadian and foreign investment, should greatly improve efforts to finance the development of recent Canadian uranium discoveries

  18. Taxi and limousine industry in Canada

    International Nuclear Information System (INIS)

    Taxi and limousine service plays an important role in the movement of people within a city. In 2004, the total revenue in this industry in Canada was $1.305 billion, and an estimated 35,339 carriers served the industry. In Canada, economic and safety regulations of taxi supply were imposed in most cities during the 1930s and 1940s and continue to this date. Although the industry is regulated, the competition law also applies. The appropriateness of these regulations continues to be challenged and regulatory reforms in the major cities in Canada have concentrated their efforts on increasing the rate of services, improving the quality of vehicles and enhancing the training of taxi drivers. Indicators for the 1999-2004 period reveal that the taxi and limousine industry in Canada did not perform very well. Revenue increased by only 1.7 per cent per year and margins deteriorated by -1.78 per cent together with the operating ratio. The purpose of this paper was to examine the taxi and limousine industry in Canada. First, the structure of the industry in Canada was examined followed by a review of the economic regulation of the industry. Recent regulatory developments in Canada and in other countries were then reviewed with arguments for or against deregulation. 28 refs., 2 tabs

  19. Petro-Canada 1997 annual report

    International Nuclear Information System (INIS)

    Petro-Canada is a dominant player in the petroleum industry in Western Canada as well as on the Grand Banks offshore Newfoundland. This report presents a review of operations, provides detailed statements of the corporation's finances, and a wealth of information of interest to shareholders. The report states that in 1997 Petro-Canada achieved record financial results, following a dramatic turnaround over the past five years. Net earnings for 1997 were $306 million, a $59 million increase over 1996. The company's share price appreciated 34 per cent in 1997 and was one of the most heavily traded stocks in Canada. The company plans to maximize shareholder value by reducing its interests in conventional oil from mature fields in western Canada and by re-investing the proceeds in natural gas development. Petro-Canada is also committed to an expansion that will double production at the Syncrude oil sands plant over the next decade and has tested large in-situ oil sands resources for potential development in northeastern Alberta. On the Atlantic coast too, Petro-Canada is delivering leadership with increasing production from Hibernia, and final approvals in place to proceed with development of the Terra Nova field. International operations are also contributing to the Corporation's profitability by delivering new production from oil fields offshore Norway and from the Sahara Desert in North Africa. tabs., figs

  20. Survey of prevalence of HIV infection, syphilis and HCV infection and related risk behaviors among club drug users in Zhejiang, 2011%浙江省2011年新型毒品使用者艾滋病、梅毒和丙型肝炎感染状况及其危险行为特征分析

    Institute of Scientific and Technical Information of China (English)

    潘晓红; 蒋均; 何欢; 陈琳; 杨介者; 张洪波; 汪宁

    2015-01-01

    目的 了解浙江省新型毒品使用者艾滋病、梅毒和丙型肝炎(丙肝)感染水平、相关行为特征以及相互关系.方法 2011年在浙江省6个城市对戒毒人员进行匿名问卷调查,调查内容包括社会人口学、使用毒品种类、性行为、接受干预情况,并采集血液进行艾滋病、梅毒和丙肝抗体检测.利用SPSS 15.0统计软件进行数据分析.结果 共调查3 253人,其中新型毒品使用者1 298人,占39.9%,北部和中部地区、女性、≤25岁年龄组、浙江省户籍和有商业性性行为的吸毒者中使用新型毒品的比例较高.1 298例新型毒品使用者中,使用冰毒者占91.2%,HIV抗体阳性率为0.1%(95%CI:0.0%~ 0.2%),梅毒抗体阳性率为8.1%(95%CI:6.6%~9.6%),丙肝抗体阳性率为17.3%(95%CI:15.2%~19.4%);艾滋病知识知晓率为12.7%,有注射吸毒史者占9.2%,最近一年有商业性性行为者占29.6%.曾接受安全套发放和咨询的比例为33.4%,曾接受艾滋病检测的比例为14.0%.多因素分析表明,来自中部和南部地区的新型毒品使用者的梅毒感染、丙肝感染和有注射吸毒行为比例高于来自北部地区者;女性是梅毒感染的相关因素;曾注射吸毒和最近一年有商业性性行为与丙肝感染相互关联;曾注射吸毒行为与最近一年商业性性行为相互关联.男性、浙江省户籍及未接受过安全套发放和咨询者更有可能发生商业性性行为.结论 新型毒品使用者梅毒和丙肝感染水平高,不安全行为发生率高,接受干预服务比例低,提示需要提高对该人群的艾滋病、梅毒和丙肝感染风险的认识,设计制定针对该人群的有效干预措施,扩大干预覆盖率.%Objective To understand the prevalence of HIV infection,syphilis and hepatitis C infection and related risk behaviors among club drug users in Zhejiang province.Methods The drug users were interviewed with questionnaires in

  1. Monitoring Adverse Drug Reactions: A Preliminary Study

    OpenAIRE

    Reynolds, J. L.

    1981-01-01

    The feasibility of family physicians functioning as monitors of adverse drug reactions (ADR) was examined over one month in ten practices. This was done as a preliminary trial, before attempting to use the 200 family physicians of the National Reporting System of the College of Family Physicians of Canada to monitor ADRs on a national basis. Both of these trials were designed to examine the feasibility of family physicians acting as prospective monitors of ADRs in newly marketed drugs and to ...

  2. Drug use in Ireland and Northern Ireland, Bulletin 2

    OpenAIRE

    Department of Health (Ireland)

    2012-01-01

    19.6.2012 This bulletin presents key findings at a local level from the third drug prevalence survey of households in both Ireland and Northern Ireland. The bulletin presents results relating to drug prevalence on a lifetime, last year (recent) and last month (current) basis for illegal and other drugs including alcohol and tobacco for each Regional Drug Task Force Area (former Health Board areas) in Ireland, and Health and Social Care Trust (HSCT) in Northern Ireland. Click here to do...

  3. A alta prevalência de prescrições de medicamentos off-label e não licenciados em unidade de terapia intensiva pediátrica brasileira High prevalence of off-label and unlicensed drug prescribing in a Brazilian intensive care unit

    OpenAIRE

    Lilian de Abreu Ferreira; Cássio da Cunha Ibiapina; Márcia Gomes Penido Machado; Eleonora Druve Tavares Fagundes

    2012-01-01

    OBJETIVO: Descrever o uso e determinar a prevalência de medicamentos de uso off-label enão licenciados em prescrições na unidade de terapia intensiva pediátrica de um hospital no sudeste do Brasil. MÉTODOS: Estudo transversal envolvendo os pacientes internados na unidade de terapia intensiva pediátrica durante o período de maio de 2008 a janeiro de 2009. A classificação quanto aos critérios de aprovação da Agência de Vigilância Sanitária (Anvisa) foi baseada em seu bulário eletrônico e no Dic...

  4. Prevalência, quantificação e resistência a antimicrobianos de sorovares de Salmonella isolados de lingüiça frescal suína Prevalence, quantification, and antimicrobial drug resistance of Salmonella serovars isolated from fresh pork sausage

    Directory of Open Access Journals (Sweden)

    Denis Augusto Spricigo

    2008-12-01

    Full Text Available A Salmonella sp. é uma das principais causas mundiais de toxinfecção alimentar. Nos últimos anos, as preocupações têm se voltado para a carne e produtos suínos tanto no aspecto de saúde pública como na sua comercialização/exportação. O presente estudo tem como objetivos: 1 verificar a prevalência de sorovares de Salmonella sp. em lingüiças tipo frescal de matéria-prima suína comercializadas em Lages (SC, bem como o seu nível de contaminação; e 2 verificar o perfil de resistência aos antimicrobianos destes isolados. Para tanto, foram coletadas 200 amostras de nove marcas, em diferentes estabelecimentos comerciais. Foram isoladas Salmonella sp. em 27% (54, sendo o sorovar Derby o mais encontrado. Apenas uma amostra apresentou uma concentração de microorganismos maior que 1,100 NMP.g-1, valor normalmente tido como necessário para causar infecção por Salmonella do grupo não-tifóide. Posteriormente, os 60 isolados foram submetidos ao teste de susceptibilidade in vitro, frente a 14 antimicrobianos. Entre esses isolados, 56,67% apresentaram resistência a pelo menos um dos antimicrobianos testados e o perfil de multirresistência foi encontrado em 20%. A prevalência elevada de produtos positivos para Salmonella sp. pode representar um risco ao consumidor, principalmente considerando-se o alto número de isolados resistentes encontrado neste estudo.Salmonella sp. is one of the main causes of food poisoning. In the last years, the main focus has been on beef and swine products because of both public health concerns and commercialization/exportation. This study was conducted in order to: 1 verify the prevalence of Salmonella serovars in fresh pork sausages commercialized in Lages, state of Santa Catarina and analyze its level of contamination; and 2 determine the profile of antimicrobial resistance of Salmonella sp. isolates. For this purpose, 200 samples of nine brands were collected from different commercial stores

  5. Leveraging Canada's nuclear infrastructure for medical innovation

    International Nuclear Information System (INIS)

    This paper discusses the role that Canada plays in nuclear medicine worldwide. Canada supplies over 75% of the world's Cobalt-60 which sterilizes 45% of all single-use medical supplies in the world. Cobalt-60 teletherapy delivers 45000 cancer treatments daily. It is used in non-destructive testing. Canada also supplies over 50% of the world's medical isotopes. NRU reactor-produced isotopes include Molybdenum 99, iodine 131, Iodine 125, Xenon 133 and Cobalt 60. MDS Nordion maintains a strategic supply agreement with AECL

  6. Electricity - a great asset for Canada

    International Nuclear Information System (INIS)

    Canada has a great national asset in its ability to generate electricity economically from its abundant hydro, coal, and uranium resources. Its nuclear industry has an excellent product. Despite lack of orders for now, the CANDU will be a competitive force when the reactor market recovers. Canada has a proven record of reliability for electricity trade with the United States. There appear to be some opportunities for plants in Canada dedicated to the export of electric power. The federal government is prepared to work closely with the provinces to develop projects which will be attractive to customers in the United States

  7. Operational expert system applications in Canada

    CERN Document Server

    Suen, Ching Y

    1992-01-01

    This book is part of a new series on operational expert systems worldwide. Expert systems are now widely used in different parts of the world for various applications. The past four years have witnessed a steady growth in the development and deployment of expert systems in Canada. Research in this field has also gained considerable momentum during the past few years. However, the field of expert systems is still young in Canada. This book contains 13 chapters contributed by 31 experts from both universities and industries across Canada covering a wide range of applications related to electric

  8. Bailarinas Exoticas, Striptease e Inmigracion en Canada.

    Directory of Open Access Journals (Sweden)

    Gloria Patricia Diaz Barrero.

    2004-01-01

    Full Text Available This article is the product of exploratory field research conducted in Toronto, Canada. It consists of in-depth interviews of Latin American women from diverse countries who obtained temporary work visas as exotic dancers. The objective of the study is to determine the ways in which women are recruited in their countries of origin, transported to Canada and what happens to them upon arrival. The author proposes that the conditions inherent to migration, more than women's legal status, determines their emotional, economic and legal well-being. However, upon obtaining legal residency in Canada, abuse committed by employers and state agents is significantly reduced.

  9. Nuclear fuel waste disposal in Canada

    International Nuclear Information System (INIS)

    Atomic Energy of Canada Limited (AECL) has developed a concept for disposing of Canada's nuclear fuel waste and is submitting it for review under the Federal Environmental Assessment and Review Process. During this review, AECL intends to show that careful, controlled burial 500 to 1000 metres deep in plutonic rock of the Canadian Precambrian Shield is a safe and feasible way to dispose of Canada's nuclear fuel waste. The concept has been assessed without identifying or evaluating any particular site for disposal. AECL is now preparing a comprehensive report based on more than 10 years of research and development

  10. [Colorectal carcinoma in Cronkhite-Canada syndrome].

    Science.gov (United States)

    Zügel, N P; Hehl, J A; Jechart, G; Tannapfel, A; Wienbeck, M; Witte, J

    2001-05-01

    We report a 63-year-old lady with Cronkhite-Canada syndrome, who developed colorectal cancer. A hemicolectomy was performed, and the tumor specimen was prepared for DNA-analysis and immunohistochemical screening. We found a mutation of p53 gene without APC- and ras-gene alteration and expression of erbB2-protooncogen. The polyps in non-hereditary Cronkhite-Canada-syndrom are neither adenomatous nor hyperplastic, but patients often develop colorectal cancers. The steps of mutation do not follow the adenoma-carcinoma sequence, first described by Vogelstein 1988. This and previous observations suggest that carcinogenesis in Cronkhite-Canada syndrome follows another independent sequence. PMID:11413916

  11. 广东省艾滋病长期抗病毒治疗患者耐药情况调查%Investigation of HIV-1 drug resistance prevalence in AIDS patients with long-term HAART therapy in Guangdong Province

    Institute of Scientific and Technical Information of China (English)

    于国龙; 鄢心革; 秦冰; 李杰; 刁丽梅; 况轶群; 付笑冰; 颜瑾; 林鹏

    2013-01-01

    Objective To find the HIV-1 drug resistance prevalence in AIDS patients with HAART therapy over four years.Methods Recruited the HIV/AIDS patients with HAART for more than four years,counted CD4 + T lymphocyte and HIV-1 viral load; and then detected the genotype drug resistance when the samples with virus load more than 1000 copies/ml by the IN-house method.Firstly amplified the whole genome of HIV-1 protease and part of reverse transcriptase genome,secondly sequenced the PCR products,and then assembled the sequence.Blast the sequence with the Stanford HIV-1 Drug Resistance Database and get the drug resistance mutation and drug resistance.Results CD4 + T Lymphocytes partly reconverted again and the virus load uncontrolled is 18.3%; about 10% patients (12 patients) were with high genotypic resistance.Major drug resistance mutations in RT region are as follows:Y181C、G190A、K101Q/E/N、M184IMV、K219KR.No major mutation was found in PI region.The NNTRI drug resistance is 100%,92% to NVP and EFV respectively.The NTRI Drug resistance to 3TC、FTC and ABC is 83%,83% and 42% respectively.Conclusions HIV-1 drug resistance in therapy patients for long time was already more than 10 percent in Guangdong province.Viruses with high drug resistance to NNTRI and NTRI were found in this population,and more measure should be done in these people.%目的 了解广东省艾滋病长期抗病毒治疗患者耐药情况.方法 在接受HAART治疗方案4年以上的120例艾滋病患者,对其中病毒载量大于1 000 copies/ml的22例患者,进行HIV-1耐药基因型检测.采用In-House方法,扩增HIV-l的POL基因蛋白酶区(PR)基因全长和逆转录酶区(RT)基因部分片段,通过HIV-1耐药数据库,获得个体耐药突变位点及药物耐受情况.结果 该人群HIV-1病毒未抑制率为18.3% (22/120);基因型高度耐药12例,高度耐药比例为10%,RT区常见耐药突变:Y181C、G190A、K101Q/E/N、M184IMV和K219KR,PR区未见主要耐药

  12. Young People, Drug Use and Family Conflict: Pathways into Homelessness

    Science.gov (United States)

    Mallett, Shelley; Rosenthal, Doreen; Keys, Deborah

    2005-01-01

    Young people who experience homelessness, in Australia and in other western contexts (US, Canada, England), are widely perceived to use and abuse alcohol and drugs. The available research indicates that homeless young people use all drug types, whether injected or otherwise, more frequently than their home-based peers. Debate exists in the…

  13. Tuberculosis treatment and drug regimens.

    Science.gov (United States)

    Sotgiu, Giovanni; Centis, Rosella; D'ambrosio, Lia; Migliori, Giovanni Battista

    2015-05-01

    Tuberculosis is an airborne infectious disease treated with combination therapeutic regimens. Adherence to long-term antituberculosis therapy is crucial for maintaining adequate blood drug level. The emergence and spread of drug-resistant Mycobacterium tuberculosis strains are mainly favored by the inadequate medical management of the patients. The therapeutic approach for drug-resistant tuberculosis is cumbersome, because of the poor, expensive, less-effective, and toxic alternatives to the first-line drugs. New antituberculosis drugs (bedaquiline and delamanid) have been recently approved by the health authorities, but they cannot represent the definitive solution to the clinical management of drug-resistant tuberculosis forms, particularly in intermediate economy settings where the prevalence of drug resistance is high (China, India, and former Soviet Union countries). New research and development activities are urgently needed. Public health policies are required to preserve the new and old therapeutic options. PMID:25573773

  14. Size estimation, HIV prevalence and risk behaviours of female sex workers in Pakistan

    International Nuclear Information System (INIS)

    Objective: To provide size estimation and to determine risky behaviours and HIV prevalence among female sex workers in Pakistan, which has progressed from a low to concentrated level of HIV epidemic. Methods: A cross-sectional study (geographic mapping and integrated behavioural and biological survey-IBBS) was conducted between August 2005 to January 2006 in Karachi, Hyderabad and Sukkur. A detailed questionnaire and dry blood spot (DBS) specimen for HIV testing were collected by trained interviewers after informed consent. The study was ethically approved by review boards in Canada and Pakistan. Results: About 14,900 female sex workers were estimated to be functional in Sindh. A total of 1158 of them were interviewed for the study. Average age of sex workers was 27.4+- 6.7 years, and the majority 787 (67.9%) were married, and uneducated 764 (65.9%). Sindhi (26.4%) was the predominant ethnicity. Mean number of paid clients was 2.1+-1.2. Three workers were confirmed HIV positive (0.75%, 95 percent CI 0.2-2.2%) from Karachi. Condom use at last sexual act was highest (68%) among brothel-based workers from Karachi, and the lowest in Sukkur where only 1.3% street-based workers reported using a condom at last sexual act. Overall use of illicit drugs through injections was negligible. Conclusion: HIV prevalence among female sex workers in Sindh, Pakistan is low but risky behaviours are present. Well organised service delivery programmes can help promoting safer practices. (author)

  15. The prevalence of natural health product use in patients with acute cardiovascular disease.

    Directory of Open Access Journals (Sweden)

    Aws Alherbish

    Full Text Available BACKGROUND: Natural health products (NHP use may have implications with respect to adverse effects, drug interactions and adherence yet the prevalence of NHP use by patients with acute cardiovascular disease and the best method to ascertain this information is unknown. OBJECTIVE: To identify the best method to ascertain information on NHP, and the prevalence of use in a population with acute cardiovascular disease. METHODS: Structured interviews were conducted with a convenience sample of consecutive patients admitted with acute cardiovascular disease to the University of Alberta Hospital during January 2009. NHP use was explored using structured and open-ended questions based on Health Canada's definition of NHP. The medical record was reviewed, and documentation of NHP use by physicians, nurses, and pharmacists, compared against the gold-standard structured interview. RESULTS: 88 patients were interviewed (mean age 62 years, standard deviation [SD 14]; 80% male; 41% admitted for acute coronary syndromes. Common co-morbidities included hypertension (59%, diabetes (26% and renal impairment (19%. NHP use was common (78% of patients and 75% of NHP users reported daily use. The category of NHP most commonly used was vitamins and minerals (73% followed by herbal products (20%, traditional medicines including Chinese medicines (9%, homeopathic preparations (1% and other products including amino acids, essential fatty acids and probiotics (35%. In a multivariable model, only older age was associated with increased NHP use (OR 1.5 per age decile [95%CI 1.03 to 2.2]. When compared to the interview, the highest rate of NHP documentation was the pharmacist history (41%. NHP were documented in 22% of patients by the physician and 19% by the nurse. CONCLUSIONS: NHP use is common in patients admitted with acute cardiovascular disease. However, health professionals do not commonly identify NHP as part of the medication profile despite its potential importance

  16. Impact of a drug-free program on broiler chicken growth performances, gut health, Clostridium perfringens and Campylobacter jejuni occurrences at the farm level.

    Science.gov (United States)

    Gaucher, M-L; Quessy, S; Letellier, A; Arsenault, J; Boulianne, M

    2015-08-01

    The use of antimicrobial agents as feed additives in poultry production is a public health concern due to the overall increase in antimicrobial resistance. Although some alternative products are commercially available, little is known on their potential impact on flock health and productivity. A prospective study involving 1.55 million birds was conducted on eight commercial broiler farms in Québec, Canada, to evaluate the impact of replacing antibiotic growth promoters and anticoccidial drugs by a drug-free program including improved brooding conditions, anticoccidial vaccination, essential oil-based feed additives, and water acidification. Various productivity and health parameters were compared between barns allocated to the conventional and the drug-free program. Zootechnical performances were monitored as productivity criteria. Clinical necrotic enteritis and subclinical enteritis occurrences, litter and fecal moistures content were measured, and microscopic gut health was evaluated. Clostridium perfringens and Campylobacter spp. strains were recovered from fecal samples collected during farm visits. Clostridium perfringens counts were used as poultry health indicators and Campylobacter prevalence was noted as well. The drug-free program was associated with a significant increase in feed conversion ratio and a decrease in mean live weight at slaughter and in daily weight gain. An increased incidence of necrotic enteritis outbreaks and subclinical enteritis cases, as well as an increase in litter moisture content at the end of the rearing period were also observed for this program. Mean microscopic intestinal lesion scores and prevalence of Campylobacter colonization were not statistically different between the two groups but the drug-free program was associated with higher Clostridium perfringens isolation rates. According to the current study design, the results suggest that substitution of antibiotic growth promoters and anticoccidial drugs by a drug

  17. Epidemiology and risk factors for drug allergy

    OpenAIRE

    Thong, Bernard Y-H; Tan, Teck-Choon

    2011-01-01

    The aim of this review was to describe the current evidence-based knowledge of the epidemiology, prevalence, incidence, risk factors and genetic associations of drug allergy. Articles published between 1966 and 2010 were identified in MEDLINE using the key words adult, adverse drug reaction reporting systems, age factors, anaphylactoid, anaphylaxis, anaesthetics, antibiotics, child, drug allergy, drug eruptions, ethnic groups, hypersensitivity, neuromuscular depolarizing agents, neuromuscular...

  18. Cost Effectiveness of Infant Vaccination for Rotavirus in Canada

    Directory of Open Access Journals (Sweden)

    Doug Coyle

    2012-01-01

    Full Text Available INTRODUCTION: Rotavirus is the main cause of gastroenteritis in Canadian children younger than five years of age, resulting in significant morbidity and cost. The present study provides evidence on the cost effectiveness of two alternative rotavirus vaccinations (RotaTeq [Merck Frosst Canada Ltd, Canada] and Rotarix [GlaxoSmithKline, Canada] available in Canada.

  19. Canada Education Savings Program: Annual Statistical Review 2011

    Science.gov (United States)

    Human Resources and Skills Development Canada, 2011

    2011-01-01

    The Canada Education Savings Program has been an initiative of the Government of Canada since 1998. As part of the Department of Human Resources and Skills Development, the program administers the Canada Education Savings Grant and the Canada Learning Bond. These two initiatives help Canadian families save for a child's post-secondary education in…

  20. 9 CFR 93.317 - Horses from Canada.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Horses from Canada. 93.317 Section 93... CONVEYANCE AND SHIPPING CONTAINERS Horses Canada 16 § 93.317 Horses from Canada. (a) Except as provided in paragraph (c) of this section, horses from Canada shall be inspected as provided in § 93.306; shall...

  1. Canada Education Savings Program: Annual Statistical Review--2009

    Science.gov (United States)

    Human Resources and Skills Development Canada, 2009

    2009-01-01

    The Canada Education Savings Program is an initiative of the Government of Canada. As part of the Department of Human Resources and Skills Development, the program administers the Canada Education Savings Grant and the Canada Learning Bond. These two initiatives help Canadian families save for a child's post-secondary education in Registered…

  2. Drug Trafficking Routes and Hepatitis B in Injection Drug Users, Manipur, India

    OpenAIRE

    Datta, Sibnarayan; Banerjee, Arup; Chandra, Partha K; Mahapatra, Pradip K.; Chakrabarti, Shekhar; Chakravarty, Runu

    2006-01-01

    Prevalence of hepatitis B genotype C in injection drug users in the northeastern Indian state of Manipur, neighboring the "Golden Triangle," correlates well with overland drug-trafficking routes, the injection drug use epidemic, and the spread of HIV. Further spread to other regions of India through mobile populations is possible.

  3. Performance-Enhancing Drugs in Sport: A Different Form of Drug Abuse.

    Science.gov (United States)

    Fuller, John R.; LaFountain, Marc J.

    1987-01-01

    Addresses an often overlooked area of drug abuse: performance-enhancing drugs in sport, used for different reasons than for recreation. Examines the seriousness and prevalence of performance-enhancing drugs and presents the results of a series of interviews with steroid users to determine their attitudes. Discusses the implications of the…

  4. 1982 Aleutian Canada goose nesting survey

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Investigation of the endangered Aleutian Canada goose (Branta canadensis leucopareia) was conducted from 1974 to 1976, again in 1977 and in 1979 on Buldir. During...

  5. Gulf Canada Resources Limited 1998 annual report

    International Nuclear Information System (INIS)

    A review of operations in 1998 and financial information from Gulf Canada Resources Limited is provided to keep shareholders abreast of company performance. Gulf Canada Resources Limited explores for, develops, produces and markets conventional and synthetic crude oil, natural gas and natural gas liquids. In 1998, the company's main operating centres were in western Canada (where it owns a nine per cent interest in the Syncrude Joint Venture), Indonesia, the North Sea and Australia. The report summarizes the company's energy resource activities, presents a detailed review of operations, and provides consolidated financial statements, and common share information. Although Gulf Canada Resources sold $ 1.2 billion worth of non-producing assets during the year, year end proved reserves of 838 million barrels of oil equivalent were less than ten per cent lower than a year earlier, reflecting reserve additions of 100 million barrels of oil equivalent. tabs., figs

  6. Mineral Operations of Latin America and Canada

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of records for over 900 mineral facilities in Latin America and Canada. The mineral facilities include mines, plants, smelters, or refineries...

  7. Canada's nuclear non-proliferation policy

    International Nuclear Information System (INIS)

    Canada's non-proliferation safeguards policy has two objectives: 1) to promote a more effective and comprehensive international non-proliferation regime; and 2) to ensure that Canadian nuclear exports will not be used for any nuclear explosive purpose. By emphasizing the key role of the Non-Proliferation Treaty, promoting reliance upon and improvements in the IAEA safeguards system, treating nuclear weapon and non-weapon states alike, and working for new approaches covering reprocessing, Canada promotes attainment of the first objective. The second is served through the network of bilateral nuclear agreements that Canada has put into place with its partners. The Canadian objective in post-INFCE forums is to persuade the international community to devise a more effective and comprehensive non-proliferation regime into which Canada and other suppliers may subsume their national requirements

  8. Emerging Churches in Post-Christian Canada

    Directory of Open Access Journals (Sweden)

    Lee Beach

    2012-09-01

    Full Text Available The traditional mainline and evangelical churches in Canada, as in most western countries, are either in decline or static. Taken as a measure of the future, the prospects for Christianity in Canada, and more broadly the West, are bleak. Post-Christian Canada, however, contains thriving alternative and innovative forms of church, often called ‘emerging’ churches. They take many forms of expression, but share common theological convictions. Based on site research and personal interviews, this article describes the various types and contexts of these churches in Canada. It then highlights three of their central theological characteristics. First, rejecting the ‘culture wars’ social involvement of Christendom churches, they embrace practices and initiatives that transform their local communities. Second, they embrace an incarnational and contextual understanding of Christian life and ministry. Eschewing mega-church franchise models, they endeavor to shape their ministry to the their local communities. Third, they adopt a comprehensive rather than compartmental spirituality.

  9. Cackling Canada goose nesting populations, Yukon Delta

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Number of potential territories, number of cackling Canada Goose nests, and percent occupancy of available territories from CCG plots on the Yukon Delta National...

  10. Canada's constitutional separation of (wind) power

    International Nuclear Information System (INIS)

    This paper investigates the impact that a federal government structure has on strategic selection of renewable energy policy instruments. The context for this study centers on wind power development in Canada. Canada is a nation that is blessed by all the attributes necessary to catalyze global leadership in installed wind power capacity. Unfortunately, the constitutional separation of powers that underpins Canada's federal system impedes the creation of a national wind power development strategy because Canada's provinces have constitutional authority over electricity governance. The insights gleaned from the case study are used to develop a conceptual framework for understanding the impact that federal structure has on policy instrument selection and efficacy under areas of federal, regional and concurrent policy jurisdiction. Finally, this framework is re-applied to identify specific approaches the Canadian federal government could take to resolve what currently amounts to be a fragmented, ineffective approach to wind power development planning.

  11. Symbolism and Militarism of Canada's North

    DEFF Research Database (Denmark)

    Williams, Mark; Burke, Danita Catherine

    2015-01-01

    Canada is often characterised as a mosaic for world cultures while contending with the difficulty of defining its national identity. Canada’s confederation in 1867 was influenced by the fear that then-British North America was at risk from the United States’ internal conflicting forces. This sense...... component of Canada’s domestic politics. Understanding the relationship dynamics of the Canadian Armed Forces, the Government of Canada and the idea of the North in Canada has broader implications for states wishing to cooperate or negotiate with Canada on matters pertaining to Canada’s Northern region....... of vulnerability bred the desire to strengthen the position of the British North American colonies while avoiding the violent internal conflicts which plagued its southern neighbour. In the decades since its formation, Canadian political parties have learnt that national campaigns, not regional or...

  12. Prescription Drugs

    Science.gov (United States)

    ... Us Search Search close Teens Teachers Parents Drugs & Health Blog NDAFW Enter Search Term(s): Teens / Drug Facts / Prescription Drugs Prescription Drugs Print What Is Prescription Drug Abuse? Also known as: Opioids: Hillbilly heroin, oxy, OC, oxycotton, percs, happy pills, vikes Depressants: ...

  13. Drug Facts

    Medline Plus

    Full Text Available ... Work? Types of Drug Treatment What Is a Relapse? Find Treatment/Rehab Resources Friends and Family Can Help Prevent Drug Abuse Help Children and Teens Stay Drug-Free Talking to Kids About Drugs: What To Say if You Were Once Addicted Drug Abuse Prevention Phone ... English ...

  14. Climate change plan for Canada

    International Nuclear Information System (INIS)

    This document updates Natsource's previous briefing on the October 24 Climate change draft plan' outlining significant changes and modifications incorporated in the November 21, 2002 version of the Climate change plan for Canada' as tabled in the House of Commons by the Minister of the Environment. The changes in the new version of the Plan are the result of continued consultations with industry and the provinces. The revised Plan addresses nine of the 12 concerns expressed by the provinces. Key changes include: (1) establishment of sectoral emissions reduction targets through negotiated covenants with a regulatory or financial backstop; (2) guaranteeing a limit of 55 Megatonnes reductions for covered sectors under the covenants and trading system; (3) introducing flexibility in timing by signaling willingness on the part of the Government to discuss acceptance of commitments over a longer term; (4) promising to work with industry on options for providing protection against risks associated with sustained carbon prices above certain levels; (5) designing implementation system in such a way as to not disadvantage those companies that have taken early action in emission reductions; (6) building in contingencies, assessing progress and adjusting the Federal approach and level of investment; (7) remaining engaged in joint efforts with the United States to minimize impacts on Canadian competitiveness. The Federal Government also recognizes the need for further research in addressing climate model uncertainties, in providing regional-scale climate change information, in future evolution of the climate in the Arctic, and in determining the record of past climate variability and extremes

  15. Gulf Canada's Russian joint venture

    International Nuclear Information System (INIS)

    After three years of evaluating prospects and negotiating with government and industry representatives, Gulf Canada established its first joint venture in the Russian Federation with Komineft, a production association from the Komi autonomous republic. Komineft has a 50% share of the venture, and the rest is shared equally between Gulf and British Gas. The operating area is at the Vozey and Upper Vozey fields in the Timan-Pechora Basin, some 1,500 km northeast of Moscow just inside the Arctic Circle. An attractive feature of the Upper Vozey project is low development costs of ca $2/bbl. In the Vozey field, the venture will set up an enhanced oil recovery demonstration project to test techniques perfected in Alberta. About 60 Canadians are involved on the project, and headquarters are in Usinsk, ca 100 km south of the oil fields. In the first half of 1992, oil production in the first phase of the venture averaged around 10,000 bbl/d and continues to increase

  16. Understanding gasoline pricing in Canada

    International Nuclear Information System (INIS)

    This brochure is designed to help consumers understand how gasoline is priced and explained why prices increase, fluctuate and vary by location, city or region. The price of a litre of gasoline reflects the costs of crude oil, refining, retailing and taxes. Taxes are usually the largest single component of gasoline prices, averaging 40 to 50 per cent of the pump price. The cost of crude oil makes up another 35 to 45 per cent of the price. Refining costs make up 10 to 15 per cent while the remaining 5 to 10 per cent represents retail costs. Gasoline retailers make a profit of about 1 cent per litre. The latest network technology allows national and regional retail chains to constantly monitor price fluctuations to change their prices at gasoline stations at a moments notice to keep up with the competition and to protect their market shares. Several government studies, plus the Conference Board of Canada, have reported that competition is working in favour of Canadian motorists. This brochure also explained the drawbacks of regulating crude and pump prices with the reminder that crude prices were regulated in the 1970s with many negative consequences. 2 tabs., 1 fig

  17. NDT in Canada - the next 20 years

    International Nuclear Information System (INIS)

    The theme for the Fifth Canadian Conference on Nondestructive Testing was 'NDT in Canada - The Next 20 years'. The three day conference with 42 presentations provided a short overview of NDT in Canada, a look at NDT in pipeline, materials, offshore, nuclear and training applications, and a glimpse into the next 20 years with recent advances in research and development as related to this 'hi-tech' field of work

  18. Occupational radiation exposures in Canada - 1994

    International Nuclear Information System (INIS)

    This is the seventeenth in a series of annual reports on Occupational Radiation Exposures in Canada. The information is derived from the National Dose Registry of the Radiation Protection Bureau, Health Canada. As in the past, this report presents the following data by occupation: average yearly whole body doses by region, dose distributions, and variations of the average doses with time. (author). 17 refs., 4 tabs., 3 figs

  19. Canada 2030: An Agenda for Sustainable Development

    OpenAIRE

    Shannon Kindornay; Centre for the Study of Living Standards

    2015-01-01

    As the Millennium Development Goals (MDGs) reach their end date in 2015, negotiations are ramping up at the United Nations for the establishment of a new set of Sustainable Development Goals (SDGs). The SDGs, to be announced in September this year, will replace the MDGs and serve as a universal framework for achieving sustainable development outcomes in all countries by 2030, including Canada. This report takes an in-depth look at what the SDGs could mean for Canada, providing a concise overv...

  20. Visible minorities` educational choices in Canada

    OpenAIRE

    Bolbocean, Corneliu

    2009-01-01

    Paper investigates educational choices of visible minorities in Canada, educational attainment and choices over fields of study. Using 2001 Canada Census data and multinomial logistic regression, research finds that choices over level of education and field of study significantly differ among visible minorities. The choices of visible minorities’ males and females differentiate substantially; insights into visible minorities` culture and role of education might explain those differences. Math...