WorldWideScience

Sample records for camp

  1. Lesbian camp: An unearthing.

    Science.gov (United States)

    Nielsen, Elly-Jean

    2016-01-01

    Camp-a sensibility, a style, and a form of artistic self-expression-is an elusive concept said to be in the eye of the beholder. To refute Susan Sontag's ( 1966 ) claims that camp is apolitical and not especially homosexual, a number of recent scholarly works have been geared toward revealing camp's fundamental gayness. With the odd footnote aside, lesbian camp has been collapsed into the category of gay male camp, if not eclipsed entirely. Despite the negligible efforts made to legitimize lesbian camp, there are numerous salient cultural examples one might draw on to illustrate, typify, and substantiate a lesbian camp sensibility. I lay the ground work for this scholarly exercise by outlining various definitions and critiques of camp, and by discussing its history and application to queer theory. Then, to unveil lesbian camp, three non-mutually exclusive categories are discussed: classic, erotic, and radical. By gathering various strands of inquiry, and various textual examples (e.g., photography, artistic performances, and literary tropes), this article attempts to reach a more inclusive and nuanced understanding of lesbian camp. PMID:26701773

  2. Recreation Summer Camps 2016

    Data.gov (United States)

    Montgomery County of Maryland — List of all Camps (Register here:https://apm.activecommunities.com/montgomerycounty/Home) to include Aquatics, Basketball, Soccer, Special Interest, General Sports,...

  3. Registration Summer Camp 2016

    CERN Multimedia

    2016-01-01

    Reminder: registration for the CERN Staff Association Summer Camp is now open for children from 4 to 6 years old.   More information on the website: http://nurseryschool.web.cern.ch/. The summer camp is open to all children. The proposed cost is 480.-CHF/week, lunch included. The camp will be open weeks 27, 28, 29 and 30, from 8:30 a.m. to 5:30 p.m. For further questions, you are welcome to contact us by email at Summer.Camp@cern.ch. CERN Staff Association

  4. Camp Joy: Embracing Diversity.

    Science.gov (United States)

    Krehbiel, Amy

    2001-01-01

    Camp Joy (Ohio) offers a racially integrated program to disadvantaged inner-city foster children. To attract quality minority staff, the camp recruits through former campers, word of mouth, a leader-in-training program, job and internship fairs, and networking with nearby colleges and social agencies. Staff training and the intrinsic rewards of…

  5. Scrum Code Camps

    DEFF Research Database (Denmark)

    Pries-Heje, Jan; Pries-Heje, Lene; Dahlgaard, Bente

    2013-01-01

    is required. In this paper we present the design of such a new approach, the Scrum Code Camp, which can be used to assess agile team capability in a transparent and consistent way. A design science research approach is used to analyze properties of two instances of the Scrum Code Camp where seven...

  6. Camp's "Disneyland" Effect.

    Science.gov (United States)

    Renville, Gary

    1999-01-01

    Describes the positive mental, physical, and social growth impacts that the camping experience had on the author, and urges camp program evaluation to plan and implement such changes. Sidebar lists steps of effective evaluation: program goals and objectives, goals of evaluation, implementation of evaluation, data analysis, and findings and…

  7. VisionCamp

    DEFF Research Database (Denmark)

    Lassen, Astrid Heidemann; Løwe Nielsen, Suna

    2009-01-01

    . Baseret på forløbet VisionCamp 2008, der satte eksplicit fokus på at kombinere fagfeltet "supply chain management" og kreativitet, illustrerer artiklen camp-metodens relevans og peger på centrale del-elementer i entreprenante kompetencer (kreative kompetencer, teknisk/faglige kompetencer og relationelle...

  8. CDC Disease Detective Camp

    Centers for Disease Control (CDC) Podcasts

    2010-08-02

    The CDC Disease Detective Camp gives rising high school juniors and seniors exposure to key aspects of the CDC, including basic epidemiology, infectious and chronic disease tracking, public health law, and outbreak investigations. The camp also helps students explore careers in public health.  Created: 8/2/2010 by Centers for Disease Control and Prevention (CDC).   Date Released: 8/2/2010.

  9. Rehabilitating camp cities : community driven planning for urbanised refugee camps

    OpenAIRE

    Misselwitz, Philipp

    2009-01-01

    Focussing on Palestine refugee camps in the Near East, this dissertation aims to shed light on the potential relevance of urban planning to refugee camp environments worldwide. In particular, there is a focus on the role architects and urban planners can play in facilitating participatory planning processes as well as providing guidance and expertise in the development of a spatial vision for Camp Cities. Part I - The Urbanisation of Refugee Camps as a Global Challenge The first part o...

  10. CCI: A Worldwide Camping Community.

    Science.gov (United States)

    Fawver, Gary Keith

    1992-01-01

    Describes the efforts of Christian Camping International (CCI), an alliance of Christian camping associations from Australia, Canada, the Far East, Latin America, New Zealand, United States, South Africa, Japan, and Brazil. The purpose of CCI is to help develop effective Christian camps, conferences, and retreat ministries. (LP)

  11. Running Boot Camp

    CERN Document Server

    Toporek, Chuck

    2008-01-01

    When Steve Jobs jumped on stage at Macworld San Francisco 2006 and announced the new Intel-based Macs, the question wasn't if, but when someone would figure out a hack to get Windows XP running on these new "Mactels." Enter Boot Camp, a new system utility that helps you partition and install Windows XP on your Intel Mac. Boot Camp does all the heavy lifting for you. You won't need to open the Terminal and hack on system files or wave a chicken bone over your iMac to get XP running. This free program makes it easy for anyone to turn their Mac into a dual-boot Windows/OS X machine. Running Bo

  12. A Summer Camp

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    正This summer,I had some special days.I joined Dongzhou International Educational Exchange Summer Camp. First,I will tell you about our foreign teachers,they are Shrina and Rebecca. They are friendly and beautiful.They are students at Oxford University. We talked about many things:famous people,subjects in England,different jobs, our deal days,western star signs,what can we say in a restaurant and so on.

  13. Interprofessional Flight Camp.

    Science.gov (United States)

    Alfes, Celeste M; Rowe, Amanda S

    2016-01-01

    The Dorothy Ebersbach Academic Center for Flight Nursing in Cleveland, OH, holds an annual flight camp designed for master's degree nursing students in the acute care nurse practitioner program, subspecializing in flight nursing at the Frances Payne Bolton School of Nursing at Case Western Reserve University. The weeklong interprofessional training is also open to any health care provider working in an acute care setting and focuses on critical care updates, trauma, and emergency care within the critical care transport environment. This year, 29 graduate nursing students enrolled in a master's degree program from Puerto Rico attended. Although the emergency department in Puerto Rico sees and cares for trauma patients, there is no formal trauma training program. Furthermore, the country only has 1 rotor wing air medical transport service located at the Puerto Rico Medical Center in San Juan. Flight faculty and graduate teaching assistants spent approximately 9 months planning for their participation in our 13th annual flight camp. Students from Puerto Rico were extremely pleased with the learning experiences at camp and expressed particular interest in having more training time within the helicopter flight simulator. PMID:27021671

  14. A Camp in the Desert

    OpenAIRE

    Heise, Aaron Kent

    2006-01-01

    A house is pulled apart into its separate rooms and joined in the out-of-doors. This collection of rooms is recognized as a camp. This move is in agreement with the site of the house, which is the foothills of the Rincon Mountains, twenty miles east of Tucson, Arizona, and bordering along Saguaro National Monument. The collection of structures that make up the buildings of the camp are joined by a path that encircles the camp, and also describes the active life of the camp. The design o...

  15. Registration Day-Camp 2016

    CERN Multimedia

    Nursery School

    2016-01-01

    Reminder Registration for the CERN Staff Association Day-camp are open for children from 4 to 6 years old More information on the website: http://nurseryschool.web.cern.ch/. The day-camp is open to all children. An inscription per week is proposed, cost 480.-CHF/week, lunch included The camp will be open weeks 27, 28, 29 and 30, from 8:30 am to 5:30 pm. For further questions, thanks you for contacting us by email at Summer.Camp@cern.ch.

  16. Summer Camp, July 2016

    CERN Document Server

    Staff Association

    2016-01-01

    During the month of July, the Staff Association’s Children’s Day-Care Centre and School EVEE held a summer camp for 4- to 6-year-olds. 24 children altogether joined in on the adventures. On the summer camp, the children got to “travel” to a different continent of the world every week. Day after day, they would pass through make-believe Customs upon arrival and get their passports stamped by a “customs officer”. For the first week, we went on a trip to Africa. In the spirit of the theme, the children got to do plenty of crafts and coloring, make their own little bindles and play various games. They even had the chance to visit the Museum of Ethnography in Geneva (MEG), learn to play the balafon and make musical instruments with Sterrenlab. For the second week, we set off to discover the Americas, exploring both the South and the North. Alongside different workshops (singing, dancing, storytelling, crafts), the children could enjoy several special ac...

  17. Encountering Child Abuse at Camp.

    Science.gov (United States)

    Durall, John K.

    1997-01-01

    Defines child abuse, including the three categories: physical, sexual, and psychological. Presents characteristics and behaviors of each type of abuse, and long-term effects. Discusses how to handle abuse that occurs at camp, and the effects on the camp. Sidebars present abuse statistics, 15 activities that promote psychological wellness, and 8…

  18. Explaining the Value of Camp.

    Science.gov (United States)

    Chenery, Mary Faeth

    1994-01-01

    Overviews the philosophy and theory of camp experiences and discusses the special benefits of camps, including experiences that can lead to significant life-changing outcomes, sound educational goals, a sense of psychological and physical safety, and helping children to deal with social problems such as the degradation of the environment and human…

  19. Comparison of work motivation in camp supervisors and camp counselors in Greek private camps

    Directory of Open Access Journals (Sweden)

    George Costa

    2008-06-01

    Full Text Available The purpose of this study was twofold. First, the study sought to better understand the work motivators that led camp supervisors and counselors to accept their job. Second, the study sought to better understand the ranking and rating of 20 work motivators from supervisors and camp counselors. Responders to the research questionnaire (n=121 were camp supervisory staff and counselors, age 15-55, working in seven private camps in Greece. Two instruments were used to collect data. The first instrument collected demographic data while the second instrument focused on ranking and rating 20 work motivators. The study suggested that Herzberg's theory (Motivator / Hygiene does not apply on a full scale. The results suggested that supervisory staff indicated good working conditions, meeting other people and carrying out personal growth are important. In addition, they don't like travel and don't consider working in a camp, as a stable job. The camp counselors want to have fun in their job and the opportunity to work with youth. They also don't consider working in a camp, as a stable job and they don't accept the responsibility in proportion to their position.

  20. Registration Day-Camp 2016

    CERN Multimedia

    Nursery School

    2016-01-01

    Registration for the CERN SA Day-camp are open for children from 4 to 6 years old From March 14 to 25 for children already enrolled in CERN SA EVE and School From April 4 to 15 for the children of CERN members of the personnel (MP) From April 18 for other children More information on the website: http://nurseryschool.web.cern.ch/. The day-camp is open to all children. An inscription per week is proposed, cost 480.-CHF/week, lunch included The camp will be open weeks 27, 28, 29 and 30, from 8:30 am to 5:30 pm. For further questions, thanks you for contacting us by email at Summer.Camp@cern.ch.

  1. Camp for Youth With Type 1 Diabetes.

    Science.gov (United States)

    Fegan-Bohm, Kelly; Weissberg-Benchell, Jill; DeSalvo, Daniel; Gunn, Sheila; Hilliard, Marisa

    2016-08-01

    Camps for youth with type 1 diabetes (T1D) have grown in size and scope since they first emerged in the 1920s. Anecdotal evidence suggests that attending camp with other youth with T1D is beneficial, largely attributed to sharing fun, active experiences and removing the isolation of living with diabetes. However, few studies have evaluated the psychosocial and medical impacts of T1D camp attendance during and after camp sessions. In addition, T1D camps have been a setting for numerous studies on a variety of T1D-related research questions not related to camp itself, such as testing novel diabetes management technologies in an active, non-laboratory setting. This paper reviews the evidence of psychosocial and medical outcomes associated with T1D camp attendance across the globe, provides an overview of other research conducted at camp, and offers recommendations for future research conducted at T1D camp. PMID:27292106

  2. 36 CFR 13.1208 - Lake Camp.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Lake Camp. 13.1208 Section 13... § 13.1208 Lake Camp. Leaving a boat, trailer, or vehicle unattended for more than 72 hours at the facilities associated with the Lake Camp launching ramp is prohibited without authorization from...

  3. Extension Sustainability Camp: Design, Implementation, and Evaluation

    Science.gov (United States)

    Brain, Roslynn; Upton, Sally; Tingey, Brett

    2015-01-01

    Sustainability Camps provide an opportunity for Extension educators to be in the forefront of sustainability outreach and to meet the growing demand for sustainability education. This article shares development, implementation, and evaluation of an Extension Sustainability Camp for youth, grades 4-6. Camp impact was measured via daily pre-and…

  4. Applications of Research to Camping.

    Science.gov (United States)

    Henderson, Karla A.

    1987-01-01

    Considers contributions of basic/theoretical, applied/practical, and marketing research to the field of camping. Outlines research concerns: application of qualitative methods, practical application of marketing research, effective research dissemination, and focus on longitudinal studies using larger samples. Affirms role of research to document…

  5. Lyme Disease Comes to Camp.

    Science.gov (United States)

    Peterson, Michael

    1989-01-01

    Describes one summer camp's plan for dealing with Lyme disease. Describes the disease and the deer tick. Recommends avoiding tick exposure through clothing, frequent examination, showers, and avoiding high grass and brushy areas, and using chemical insect repellents and chemicals to kill ticks in deer mouse nests. (DHP)

  6. AVTC Hosts TechnoCamp

    Science.gov (United States)

    Miner, Brenda

    2006-01-01

    The Area Vo-Tech Center (AVTC) in Russellville, Arkansas, recently hosted its first TechnoCamp to encourage enrollment based on the aptitude and interest level of the students enrolling in the various programs. The center currently offers student enrollment in auto technology, computer engineering, cosmetology, construction technology, drafting…

  7. Is juvenile boot camp policy effective

    Directory of Open Access Journals (Sweden)

    Kübra Gültekin

    2012-04-01

    Full Text Available Militaristic boot camps became very popular in the U.S. in the early 1990’s as an alternative to traditional prisons and probation. Less recidivism and less cost were the shibboleths of correctional boot camps. The boot camps are believed to reduce the number of repeat offenders and to lower operational costs. The rehabilitation programs and aftercare activities are thought to bring ongoing changes in inmates’ behaviors. Therefore, boot camps are strongly supported by politicians and the public. Tax dollars are spent to operate the boot camps. However, despite the fact that only two decades have passed since the existence of juvenile boot camps, numerous studies have declared that juvenile boot camp prisons are ineffective in reducing future offenses of inmates, operational costs, and in continually changing the behaviors of young offenders.

  8. Huijia School Summer Camp Program

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    As an open and international educational institution, Beijing Huijia Private School is located in Changping, a scenic district in Beijing's northern suburb. In order to strengthen international cultural exchanges, promote the study of Chinese language and the spread of Chinese culture, and make the world know more about China, Huijia School regularly organizes various summer camps for students of different ages every year. Until now, we have already successfully received more than 1,000 students from hom...

  9. Camping: A Tool for Relationship Maintenance?

    OpenAIRE

    Morrow, Rosie; Rodriguez, Alison; King, Nigel

    2014-01-01

    Purpose - Purpose: To investigate individuals’ lived experience of camping, and to explore the effects of camping on relationships. Design/methodology/approach - Design: The research adopted a descriptive phenomenological approach (Langdridge, 2007). Guided interviews were carried out with four participants, recalling their most memorable camping experience, with the aid of photographs to elicit memories. Analysis followed Colaizzi’s (1978) seven stage analysis and findings were discussed...

  10. College Camp Fairs: Tips for Hosts, Directors, and Students.

    Science.gov (United States)

    Gaskill, Paul L.; Campbell, Don

    1995-01-01

    Camp fairs are held on college campuses to recruit students for summer camp positions. Provides marketing and promotion strategies, recruiting suggestions for camp directors, tips for students helping to organize the fair, and suggestions for students who want to secure a summer camp position. Includes a sample camp fair evaluation. (LP)

  11. L'Europe des camps

    OpenAIRE

    Belguendouz, Abdelkrim; Bietlot, Mathieu; Bigo, Didier; Fischer, Nicolas; GARCIA CASTRO, Antonia; Intrand, Caroline; migreurop,; Perrouty, Pierre-Arnaud; Ragazzi, Francesco; Rodier, Claire; Teule, Catherine; VALLUY1, Jérôme

    2005-01-01

    Les pays occidentaux développent une culture politique de séparation et d'opposition entre ceux qui peuvent circuler librement dans le monde et ceux pour qui cela est interdit. Elle porte d'ailleurs un nom : le visa Schengen. Cela se traduit par la prolifération de camps d'exilés, où sont enfermés de force des hommes venus en Europe pour y trouver refuge, et par la subordination de pays voisins réduits à la fonction répressive de gardien des frontières... The countries of the European Union, ...

  12. Forest Fire: A Crisis Reality for Camp.

    Science.gov (United States)

    Brown, Don; Mickelson, Rhonda

    2002-01-01

    Two camp directors were interviewed about evacuations from their camps due to forest fires. Topics covered include descriptions of the events; actions taken; aspects of advance planning that proved helpful; unexpected portions of the experience and resultant changes made in plans; relations with outside agencies, the media, and parents; working…

  13. Teenagers and Risk-Taking at Camp.

    Science.gov (United States)

    Woods, Ann

    2002-01-01

    Teen risk-taking is normal, healthy developmental behavior. Teens act out their fantasies--good and bad--at camp because it is a safe place away from parents. Signs of unhealthy risk-taking, camp staff responses, and how the September 11 tragedy might affect risk-taking are discussed. Sidebars describe tips for understanding adolescent behavior…

  14. Children with Cancer: Positive Benefits of Camp.

    Science.gov (United States)

    Winfree, Christy; Williams, Richard; Powell, Gwynn M.

    2002-01-01

    A relatively new method of helping pediatric cancer patients cope with their illness is specially designed summer camps. Camp helps children with cancer address psychological effects of the disease, bodily changes, and self-concept, and helps parents and siblings cope. Sidebars present resources and tips on incorporating children with cancer into…

  15. Dealing with World Issues in Camp.

    Science.gov (United States)

    Kujawa, Charles

    1986-01-01

    Discusses dealing with global issues in the camp setting in a way that broadens young people's world views. Topics include the educational advantages of the camp setting, desired outcomes for campers, guidelines for staff, and program ideas for dealing with issues such as environmental awareness, racism, and economic justice. (JHZ)

  16. Day Camp Manual: Staff. Book II.

    Science.gov (United States)

    Babcock, William

    Book II of a 5-book day camp manual focuses on staff selection and training. Following the philosophy that developing an effective staff is the responsibility of the camp director, the book contains major sections on staff recruitment (sources of staff, problems, selection procedures, job descriptions, personnel practices); guidelines for job…

  17. Accounting Boot Camp for College Juniors

    Science.gov (United States)

    Myring, Mark; Wrege, William; Van Alst, Lucinda

    2008-01-01

    We describe a day-long introduction to new accounting majors, which we call a boot camp. Boot camp it is an effort to make juniors more aware of their identity, career purposes and learning resources that are now parts of their world, much of which is not covered explicitly in the accounting curriculum. This paper provides an overview of the…

  18. Opening of a summer camp at CERN

    CERN Multimedia

    Nursery School

    2015-01-01

    The Staff Association has the pleasure to announce the opening of a summer camp in l’EVE et Ecole de l’AP du CERN. With a capacity of 40 children, aged 4 to 6 years, it will be open from July 6 to 30. Registration Summer camp 2015 Registration for the CERN SA Summer camp for children aged 4 to 6 is open 16 to 30 April 2015 More information on the website: http://nurseryschool.web.cern.ch/ The Summer camp is open to all children of CERN Staff. An inscription per week is proposed, cost 480.-CHF/week, lunch included. The camp will be open weeks 28, 29, 30 and 31, from 8:30 am to 5:30 pm.

  19. "It's not Just Camp!": Understanding the Meaning of Children's Cancer Camps for Children and Families.

    Science.gov (United States)

    Laing, Catherine M; Moules, Nancy J

    2016-01-01

    The purpose of this philosophical hermeneutic inquiry was to understand the meaning of children's cancer camps for the child with cancer and the family. Six childhood cancer families and 5 cancer camp counselors were interviewed, in order to bring understanding to this topic. Findings from this research revealed that camp means different things for different families, and that much is at play in the cancer camp experience: the healing and developmental power of play, finding acceptance and fit, grief as something to live with versus "get over," storytelling as a means of reshaping and understanding traumatic experiences, and the solidarity of the community as one that creates intense, healing bonds. Children's cancer camps, we conclude, should be considered a necessity, versus a luxury, and could even be thought of as a psychosocial intervention for some children and families. Barriers such as structure of funding and access to resources are present and likely due to the separateness of camps from hospital programs. PMID:25643975

  20. (Compendium of State Laws and Regulations for Youth Camps).

    Science.gov (United States)

    Brookhiser, Judy, Comp.; van der Smissen, Betty, Comp.

    State laws and regulations applicable to youth camp operations provided by state agencies are organized in this Compendium under ten major headings; personnel; program safety; personal health, first aid, and medical services; site and facilities; sanitation; food service; transportation; primitive camping and out-of-camp trips; day camping; and…

  1. Design and Development Issues for Educational Robotics Training Camps

    Science.gov (United States)

    Ucgul, Memet; Cagiltay, Kursat

    2014-01-01

    The aim of this study is to explore critical design issues for educational robotics training camps and to describe how these factors should be implemented in the development of such camps. For this purpose, two robotics training camps were organized for elementary school students. The first camp had 30 children attendees, and the second had 22. As…

  2. 2012 USGS Lidar: Brooks Camp (AK)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. Geological Survey (USGS) had a requirement for high resolution Lidar needed for mapping the Brooks Camp region of Katmai National Park in Alaska....

  3. Food Safety While Hiking, Camping and Boating

    Science.gov (United States)

    ... Standard Forms FSIS United States Department of Agriculture Food Safety and Inspection Service About FSIS District Offices ... Web Content Viewer (JSR 286) Actions ${title} Loading... Food Safety While Hiking, Camping & Boating Outdoor activities are ...

  4. A specialized program for children with developmental disabilities within a "typical" overnight summer camp: Camp Ramah's Tikvah Program.

    Science.gov (United States)

    Blas, Howard I

    2007-10-01

    The Tikvah Program is an overnight camping program at Camp Ramah in New England that serves campers with a range of developmental disabilities. The program has evolved over its 37-year history and includes a camping program, vocational training program, and inclusion program. Select graduates are hired by the camp for summer employment. The Tikvah Program offers a model for serving campers with special needs within a larger "typical" summer camp. Although serving the needs of such campers offers unique challenges, the presence of such a program in a regular summer camp offers tremendous opportunities and benefits for campers with special needs and more typically developing campers. PMID:17823062

  5. Camp Health Aide Manual = Manual para trabajadores de salud.

    Science.gov (United States)

    Robinson, June Grube; And Others

    This bilingual manual serves as a textbook for migrant Camp Health Aides. Camp Health Aides are members of migrant labor camps enlisted to provide information about health and social services to migrant workers and their families. The manual is divided into 12 tabbed sections representing lessons. Teaching notes printed on contrasting paper…

  6. The Effect of a Camp Experience on Self Esteem.

    Science.gov (United States)

    Dorian, Alexia Eve

    Two groups of American adolescents of Greek descent (12-15 year olds N=90 and 16-18 year olds N=166) at an Orthodox Christian Camp in Greece responded to the Rosenberg Self Esteem Scale (1965). Campers took the test on the first day of camp (pretest) and then two weeks later at the camp's conclusion (posttest). All subjects showed a significant…

  7. Summer Camp and Positive Youth Development: Program with Romanian Youth

    Science.gov (United States)

    Feenstra, Jennifer S.

    2015-01-01

    A variety of activities are used in camps to help promote positive youth development, improving social skills and self-esteem in campers. I expanded on previous camp research in this study to address the influence camps have on trust, belief in the honesty of others, empowerment, and care for others in youth in Eastern Europe. Since 1999, New…

  8. 49 CFR 218.80 - Movement of occupied camp cars.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Movement of occupied camp cars. 218.80 Section 218... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Occupied Camp Cars § 218.80 Movement of occupied camp cars. Occupied cars may not be humped or flat switched unless coupled...

  9. 7 CFR 502.6 - Hunting, fishing, camping, horseback riding.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Hunting, fishing, camping, horseback riding. 502.6..., MARYLAND § 502.6 Hunting, fishing, camping, horseback riding. The use of BARC grounds for any form of hunting, fishing, camping, or horseback riding is prohibited. Further, the use of these grounds...

  10. Sexual Harassment at Camp: Reducing Liability.

    Science.gov (United States)

    Oakleaf, Linda; Grube, Angela Johnson

    2003-01-01

    Employers are responsible for sexual harassment perpetrated by a supervisor. Camps may be responsible for sexual harassment between campers. Steps to reduce liability include providing multiple channels for reporting sexual harassment; having written policies prohibiting sexual harassment and procedures for reporting it; posting these policies and…

  11. Conduct Disorders: Are Boot Camps Effective?

    Science.gov (United States)

    Jeter, LaVaughn V.

    2010-01-01

    Youth diagnosed with "conduct disorder" are often placed in programs using forced compliance and coercive control. One type of intervention used to treat conduct disorder is the boot camp. The basic idea is that disruptive behaviors can be corrected by strict behavioral regulation and an emphasis on skills training (Weis & Toolis 2009; Weis,…

  12. The Gold Mining Camp: A Simulation Game.

    Science.gov (United States)

    Stoltman, Joseph P.; Keach, Everett T., Jr.

    This economics simulation game complements the third grade Gold Mining Unit developed by Project Social Studies at the University of Minnesota. The simulation is designed for three purposes: 1) to reinforce the prior learning which occurs in the gold mining camp unit; 2) to involve eight-year-olds in the process of solving simulated economic…

  13. The Perspective of Camping Tourism in Romania

    Directory of Open Access Journals (Sweden)

    Andreea Marin-Pantelescu

    2015-12-01

    Full Text Available The tourists, who dream of a perfect holiday, with long term positive effects, find in camping a form of tourism that diminishes the impact of urban environment, and increase the chances of return to nature in a green place without stress and technology. Nowadays, the quests for technological detoxification methods are at high level and the customers are willing to pay a price for these services. The perspective of camping tourism in Romania represents an economic study regarding the supply and the demand of the camping services in our country and the future evolution of these particular services. The camping services evolution will be forecast using the linear trend statistical method in order to see the number of the tourist willing to use and enjoy the nature, the fresh air and the self-services regarding the accommodation, food and beverage or transportation. The impact of the paper discovery will provide better understanding of a tourism market steadily increasing and producing added value for all the stakeholders involved in the tourism sector.

  14. Camp Crisis Management: Responding to New Challenges.

    Science.gov (United States)

    Evans, Will

    2002-01-01

    Camps should have crisis management plans. Steps to formulating a plan include involving appropriate off-site agencies, identifying potential threats, gathering resources, crafting an appropriate response, training via role-playing, managing incoming and outgoing information, and writing it down. Sidebars present resources, successful response…

  15. Summer camps for children with burn injuries: a literature review.

    Science.gov (United States)

    Maslow, Gary R; Lobato, Debra

    2010-01-01

    The first summer camps for children with burn injuries started over 25 years ago, and as of 2008, there were 60 camps worldwide. This review examines the literature on summer pediatric burn camps. The authors describe common characteristics of burn camp structure, activities, and staffing and then examine the scientific evidence regarding the effect of burn camp programs on campers and camp staff volunteers. A search of Pubmed and Psychinfo databases from 1970 to 2008 for articles related to pediatric burn summer camps identified 17 articles, of which 13 fit the inclusion criteria. Existing literature consists primarily of qualitative studies, suggesting that burn camp can decrease camper isolation, improve self-esteem, and promote coping and social skills. Studies examining volunteer staff at burn camp have consistently found that there are both personal and professional benefits. Quantitative studies of self-esteem have yielded equivocal results. No studies have examined safety or the effect of burn camp on medical or rehabilitation outcomes. For the past 25 years, pediatric summer camps for children with burn injuries have played an important rehabilitation role and provided a strong community that benefits both campers and staff. Future research using more rigorous research methods and examining a broader range of outcomes (eg, safety and medical/rehabilitation outcomes) is recommended. PMID:20644489

  16. Communication Boot Camp: Discover the Speaker in You!

    Directory of Open Access Journals (Sweden)

    Zuraidah Binti Ali

    2013-07-01

    Full Text Available Learning can take place almost anywhere, and this is especially true for our undergraduates who wish to become public speakers. Besides university course and public speaking workshops on campus grounds, undergraduates are now looking for a different learning environment – communication boot camps!! This study presents a compilation of learners’ experience, fun-filled activities, insightful feedback and memorable boot camp moments as captured in camp photos and feedback surveys. It involves a total of thirty seven undergraduates who enrolled in a Communication Boot Camp at Janda Baik, Pahang. Results show that Communication Boot Camp is a successful strategy to groom public speakers with a positive correlation between camp success and camp objectives, particularly in reducing shyness, motivating participants to become public speakers and discovering their talent and skills. In short, the study adds to the promise of zest and delight in public speaking.

  17. Xerophthalmia clinics in rural eye camps.

    Science.gov (United States)

    Desai, N C; Desai, S; Desai, R

    1992-05-01

    Even though the primary prevention of many eye diseases can be effectively incorporated into the existing pattern of rural eye camps, efforts in this direction are restrained and insubstantial. We describe our technique and experience in the prevention of xerophthalmia by organising a distinct entity called a xerophthalmia clinic in our eye camps. The clinic consists of an Ophthalmologist or an Ophthalmic assistant who will exclusively examine children who come to the eye camp. This is perhaps, the first report on rural xerophthalmia clinics, in ophthalmic literature. Over a seven year period from 1984 to 1990 we have conducted 71 xerophthalmia clinics amongst the ninty eye camps organised. A total of 11,370 children were examined in the xerophthalmia clinic out of which 18.9% were afflicted with the disease. Therapeutic doses of Vitamin A were administered on the spot to the afflicted and prophylactic doses were administered to the rest. Intensive health education efforts are made through clinics to effectuate change in dietry habits towards consumption of locally grown DGLV (Dark Green Leafy Vegetables) like Anthenum, chenopodium and Amaranthus. A bipronged offensive consisting of mega-dosing and health education is, for the present and the foreseeable future, the best strategy to combat xerophthalmia in this desert region. A year by year breakdown of prevalence rates in the present study shows that in years of severe drought the prevalence of xerophthalmia increases three fold over the non-drought or mild drought years, thereby demonstrating that drought is a substantial risk factor in developing countries leading to vitamin A deficiency and xerophthalmia. PMID:1452416

  18. Core Concepts: Orthopedic Intern Curriculum Boot Camp.

    Science.gov (United States)

    Seeley, Mark A; Kazarian, Erick; King, Brandon; Biermann, Janet S; Carpenter, James E; Caird, Michelle S; Irwin, Todd A

    2016-01-01

    Orthopedic surgical interns must gain a broad array of clinical skills in a short time. However, recent changes in health care have limited resident-patient exposures. With the reported success of simulation training in the surgical literature, the American Board of Orthopaedic Surgery (ABOS) and Residency Review Committee for Orthopaedic Surgery have required that surgical simulation training be a component of the intern curricula in orthopedic surgical residencies. This study examined the short-term effectiveness of an orthopedic "intern boot camp" covering 7 of 17 simulation training concept modules published by the ABOS. Eight orthopedic post-graduate year 1 (PGY-1) residents (study group) completed a structured 3-month curriculum and were compared with 7 post-graduate year 2 (PGY-2) residents (comparison group) who had just completed their orthopedic surgical internship. Seven core skills were assessed using both task-specific and global rating scales. The PGY-1 residents demonstrated a statistically significant improvement in all 7 modules with respect to their task-specific pre-test scores: sterile technique (P=.001), wound closure (Pcasting and splinting (P<.001), arthrocentesis (P=.01), basics of internal fixation (P<.001), and compartment syndrome evaluation (P=.004). After the camp, PGY-1 and -2 scores in task-specific measures were not significantly different. A 3-month simulation-based boot camp instituted early in orthopedic internship elevated a variety of clinical skills to levels exhibited by PGY-2 residents. PMID:26730688

  19. Cardiac cAMP: production, hydrolysis, modulation and detection

    OpenAIRE

    Cédric eBOULARAN; Céline eGALES

    2015-01-01

    Cyclic adenosine 3’,5’-monophosphate (cAMP) modulates a broad range of biological processes including the regulation of cardiac myocyte contractile function where it constitutes the main second messenger for β-adrenergic receptors’ signaling to fulfill positive chronotropic, inotropic and lusitropic effects. A growing number of studies pinpoint the role of spatial organization of the cAMP signaling as an essential mechanism to regulate cAMP outcomes in cardiac physiology. Here, we will briefl...

  20. Cardiac cAMP: production, hydrolysis, modulation and detection

    OpenAIRE

    Boularan, Cédric; Gales, Céline

    2015-01-01

    Cyclic adenosine 3′,5′-monophosphate (cAMP) modulates a broad range of biological processes including the regulation of cardiac myocyte contractile function where it constitutes the main second messenger for β-adrenergic receptors' signaling to fulfill positive chronotropic, inotropic and lusitropic effects. A growing number of studies pinpoint the role of spatial organization of the cAMP signaling as an essential mechanism to regulate cAMP outcomes in cardiac physiology. Here, we will briefl...

  1. Concentration Camp Rituals: Narratives of Former Bosnian Detainees

    OpenAIRE

    Basic, Goran

    2015-01-01

    In the German camps during the Second World War, the aim was to kill from a distance, and the camps were highly efficient in their operations. Previous studies have thus analyzed the industrialized killing and the victims' survival strategies. Researchers have emphasized the importance of narratives but they have not focused on narratives about camp rituals, or analyzed post-war interviews as a continued resistance and defense of one’s self. This article tries to fill this gap by analyzin...

  2. Communication Boot Camp: Discover the Speaker in You!

    OpenAIRE

    Zuraidah Binti Ali; Noor Hafiza Binti Nor Azmi; Alicia a/p Phillip; Mohd Zin bin Mokhtar

    2013-01-01

    Learning can take place almost anywhere, and this is especially true for our undergraduates who wish to become public speakers. Besides university course and public speaking workshops on campus grounds, undergraduates are now looking for a different learning environment – communication boot camps!! This study presents a compilation of learners’ experience, fun-filled activities, insightful feedback and memorable boot camp moments as captured in camp photos and feedback surveys. It involves a ...

  3. Oscillations of cAMP with the cardiac cycle.

    Science.gov (United States)

    Wikman-Coffelt, J; Sievers, R; Coffelt, R J; Parmley, W W

    1983-03-16

    Oscillations of cAMP with the cardiac cycle were demonstrated in the rat heart using a stimulator-triggered rapid freeze-clamp to decrease the temperature of the heart from 37 degrees C to -80 degrees C in 5 msec (20,000 degrees/sec) at a predetermined phase of the cardiac cycle. The nucleotide, cAMP, oscillated 60% with the cardiac cycle during normal working conditions, the higher cAMP value occurring during systole. PMID:6301471

  4. Cardiac cAMP: production, hydrolysis, modulation and detection.

    Science.gov (United States)

    Boularan, Cédric; Gales, Céline

    2015-01-01

    Cyclic adenosine 3',5'-monophosphate (cAMP) modulates a broad range of biological processes including the regulation of cardiac myocyte contractile function where it constitutes the main second messenger for β-adrenergic receptors' signaling to fulfill positive chronotropic, inotropic and lusitropic effects. A growing number of studies pinpoint the role of spatial organization of the cAMP signaling as an essential mechanism to regulate cAMP outcomes in cardiac physiology. Here, we will briefly discuss the complexity of cAMP synthesis and degradation in the cardiac context, describe the way to detect it and review the main pharmacological arsenal to modulate its availability. PMID:26483685

  5. Yoga camp in Ayurvedgrams of Chhattisgarh

    OpenAIRE

    Raghavendra Madhu; Nilesh Jain

    2012-01-01

    The clinical and empirical health benefits of yoga and pranayam have been reiterated through research. Yoga is being adopted as a system to alleviate the burden of noncommunicable diseases (NCDs) across the globe. The Directorate of AYUSH, Government of Chhattisgarh (DoA, GoCG) conducts annual 5-day-yoga camp across 146 Ayurvedgrams in the State. The present article brings out the AYUSH initiatives the State is taking toward active ageing. A total of 71,096 people participated in the 5-day-yo...

  6. Complexities of speech in Palestinian refugee camps

    OpenAIRE

    Hawker, Nancy

    2011-01-01

    This paper is a report on work in progress. I have recently finished my fieldwork in three refugee camps in the West Bank: Shuafat RC, which is in the Jerusalem Municipal Area, Dheisheh RC, which is in the Bethlehem Governorate, and Tulkarem RC, which is in the north of the West Bank near the Green Line. I have been recording the speech of respondents in these locations to find out whether contact with Hebrew speakers is effecting language variation and change in spoken Palestinian Arabic. So...

  7. Creating a Healthy Camp Community: A Nurse's Role.

    Science.gov (United States)

    Lishner, Kris Miller; Bruya, Margaret Auld

    This book provides an organized, systematic overview of the basic aspects of health program management, nursing practice, and human relations issues in camp nursing. A foremost assumption is that health care in most camps needs improvement. Good health is dependent upon interventions involving social, environmental, and lifestyle factors that…

  8. 14 CFR 91.1417 - CAMP: Mechanical interruption summary report.

    Science.gov (United States)

    2010-01-01

    ... Ownership Operations Program Management § 91.1417 CAMP: Mechanical interruption summary report. Each program manager who maintains program aircraft under a CAMP must mail or deliver, before the end of the 10th day... and engine and aircraft on which it was installed. Propeller featherings for training,...

  9. Students Become Scientists at Science Skills Boot Camp | Poster

    Science.gov (United States)

    At the 2016 Science Skills Boot Camp (SSBC), a one-day training program designed for NIH summer interns with little or no prior research experience, students gathered to learn about basic research and laboratory skills. The boot camp provided a unique opportunity for interns to expand their knowledge of simple bench techniques, scientific papers, and ways to communicate their research.

  10. "Don't Laugh at Me" Coming to Camps.

    Science.gov (United States)

    Coleman, Marla

    2000-01-01

    Describes a multimedia resource developed for camps by the American Camping Association and Peter Yarrow, of Peter, Paul, and Mary, to help children express and manage their emotions, cooperate and appreciate the individual strengths that each child brings to a group, celebrate diversity, and practice negotiating and resolving conflict creatively.…

  11. Recidivism among Arkansas Boot Camp Graduates after 12 Months.

    Science.gov (United States)

    Toombs, Nancy J.; Benda, Brent B.; Corwyn, Robert Flynn

    1997-01-01

    Examines recidivism among 792 graduates of Arkansas' only boot camp. Results indicate that the primary predictors of recidivism were the type of offenses (drugs vs. others), race, and infractions while in boot camp. However, none of the predictors accounted for more than minor proportions of the variance in recidivism. (RJM)

  12. Making STEM Fun: How to Organize a STEM Camp

    Science.gov (United States)

    Davis, Kimberly E. Bryant; Hardin, Stacey E.

    2013-01-01

    The work from the University of Central Florida's STEM summer camp (sponsored by Workforce Central Florida) is shared. The camps targeted low-SES schools with a high percentage of students on free and reduced lunch as well as high percentages of students with. Students were given preassessments and postassessments to gauge their knowledge of and…

  13. Residential Grief Camps: An Initial Phenomenological Study of Staff Perspectives

    Science.gov (United States)

    Brown, Tiffany B.; Kimball, Thomas G.

    2012-01-01

    Research has focused primarily on the impact of death on family functioning and the stages and tasks of grief, though little attention has been given to grief camps or the experiences of those who work there. This study explored the experiences of staff at a four-day overnight children's grief camp. Eight participants reported their experience of…

  14. Camp GLOW (Girls Leading Our World): Handbook for Volunteers.

    Science.gov (United States)

    Peace Corps, Washington, DC. Information Collection and Exchange Div.

    Camp GLOW (Girls Leading Our World) began in Romania in 1995 as a weeklong leadership camp with the purpose of encouraging young women to become active citizens by building their self-esteem and confidence, increasing their self-awareness, and developing their skills in goal-setting, assertiveness, and career and life planning. Since that first…

  15. How Did a Science Camp Affect Children's Conceptions of Science?

    Science.gov (United States)

    Metin, Duygu; Leblebicioglu, Gulsen

    2011-01-01

    Science explores nature and the most authentic way of introducing science is creating learning environments in the nature and let children make their own discoveries in the nature as real scientists. Science camps would be an opportunity for this kind of science education. This study introduces a science camp and reports findings regarding its…

  16. Camping under Western Stars: Joan Crawford in "Johnny Guitar."

    Science.gov (United States)

    Robertson, Pamela

    1995-01-01

    Examines the dissonant and "camp" effect inherent in describing "Johnny Guitar" as a Joan Crawford western. Argues that the film's camp effect depends on its crossing of a female star vehicle with the western, a stereotypically masculine genre. Summarizes Crawford's childhood and rise to fame. Concludes by exploring the lesbian and "butch-femme"…

  17. Vision, Leadership, and Change: The Case of Ramah Summer Camps

    Science.gov (United States)

    Reimer, Joseph

    2010-01-01

    In his retrospective essay, Seymour Fox (1997) identified "vision" as the essential element that shaped the Ramah camp system. I will take a critical look at Fox's main claims: (1) A particular model of vision was essential to the development of Camp Ramah; and (2) That model of vision should guide contemporary Jewish educators in creating Jewish…

  18. Architecture of Stalin’s Prison Camps in Yakutia

    Directory of Open Access Journals (Sweden)

    Nikolai Kradin

    2014-09-01

    Full Text Available Based on archive and field studies, the article considers architecture of prison camp facilities built on the territory of Yakutia during Stalin’s terror. With the help of field studies, measurements and photofixation we have revealed compositional, planning and design features of bridges and prison camp facilities and analyzed their location.

  19. Summer Camp Experiences: Parental Perceptions of Youth Development Outcomes

    Science.gov (United States)

    Henderson, Karla A.; Whitaker, Leslie Scheuler; Bialeschki, M. Deborah; Scanlin, Margery M.; Thurber, Christopher

    2007-01-01

    Every summer more than 10 million children attend day or resident (sleep-over) camps sponsored by churches, not-for-profit youth agencies, and independent operators. This study explored the outcomes of a 1-week or longer camp experience from the perspective of parents. A national sample of almost 2,300 parents responded to pre-, post-, and…

  20. Crisis Management: How to Handle a Salmonella Outbreak at Camp.

    Science.gov (United States)

    Becker, William A.; Popkin, Rodger

    1992-01-01

    Details events of six days during Salmonella outbreak at camp in North Carolina. Explains how camp handled 280 sick campers and staff, well campers, news media, and parents. Based on an epidemiologic survey of food eaten, it was suspected that the culprit of the outbreak was a meat item. Offers suggestions for crisis management in the camp…

  1. 14 CFR 91.1423 - CAMP: Maintenance organization.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false CAMP: Maintenance organization. 91.1423... Operations Program Management § 91.1423 CAMP: Maintenance organization. (a) Each program manager who... the performance of that work, must have an organization adequate to perform the work. (b) Each...

  2. Turning Neighbors into Friends: The Los Angeles Camp Experience.

    Science.gov (United States)

    Jenya, Judith

    2002-01-01

    A camp for Los Angeles (California) children traumatized by war, community violence, and hatred gives them time to heal and feel safe. The camp's theme of reconciliation and nonviolence is expressed by an all-volunteer staff through community, teamwork, and cooperation. Nature's diversity is used to show how diverse groups can interact, thrive,…

  3. EduCamp Colombia: Social Networked Learning for Teacher Training

    Science.gov (United States)

    Fonseca, Diego Ernesto Leal

    2011-01-01

    This paper describes a learning experience called EduCamp, which was launched by the Ministry of Education of Colombia in 2007, based on emerging concepts such as e-Learning 2.0, connectivism, and personal learning environments. An EduCamp proposes an unstructured collective learning experience, which intends to make palpable the possibilities of…

  4. Camp Sports Injuries: Analysis of Causes, Modes and Frequencies

    Directory of Open Access Journals (Sweden)

    Panagiota Papageorgiou

    2008-12-01

    Full Text Available The purpose of this study was the description of sports injuries sustained by campers at summer camps, aged 7-15 years. A sample of 8 camps from the Greek camp population participated in this sport injury surveillance study. Doctors and camp directors completed reports detailing the number of sports injuries events sustained and provided specific information about each event. During the period of the study, 337 sport injury reports were completed. A total of 237 (70.3% boys and 100 (29.7% girls reported having a sport injury. Age of campers sustaining a sport injury was 10-12 years old (60.8%. The frequency of sports injuries was highest during the first camp season. The leading causes of sports injuries in children’s were: falls, crushed by object, collision with other person and slips. Cut/scratch injuries were the most common diagnoses (38.9%. Football, basketball and volleyball were the most frequent sport activities for injuries. Reports based surveillance systems can be successfully used to conducts sport injury surveillance among children attending summer camps. Data collected via such systems can be used to calculate sports injury rates, to describe patterns of sport injury and to identify risk factors for camper – related sport injuries. The results provide necessary information to develop prevention interventions to decrease the number of youth whose camp experiences are negatively affected by sport injury.

  5. How to run a sports camp – legally speaking

    Directory of Open Access Journals (Sweden)

    Steven Monk

    2016-04-01

    Full Text Available Camps are a great way to keep kids active throughout the summer and to make money for the program sponsoring them. Planning is needed for a sports camp to be safe for both the camp personnel and the athletes, and to minimize legal negligence.  Having a risk management plan in place is important to insure that everyone is aware of the risks of participating. Background checks on camp personnel help ensure the camp leaders and coaches do not have a criminal background.  It is important to inspect the facilities/equipment to make sure they are safe to use.  Athletic trainers help with injuries that may occur with participation.  Supervisors make sure that everyone is accounted for and camp rules help the campers behave in an appropriate manner.  When planning activities, it is important to look at the skill level of the athletes. If all of these areas are covered, camps should be legally protected if an issue were to arise.

  6. Imaging alterations of cardiomyocyte cAMP microdomains in disease

    Directory of Open Access Journals (Sweden)

    Alexander eFroese

    2015-08-01

    Full Text Available 3’,5’-cyclic adenosine monophosphate (cAMP is an important second messenger which regulates heart function by acting in distinct subcellular microdomains. Recent years have provided deeper mechanistic insights into compartmentalized cAMP signaling and its link to cardiac disease. In this mini review, we summarize newest developments in this field achieved by cutting-edge biochemical and biophysical techniques. We further compile the data from different studies into a bigger picture of so far uncovered alterations in cardiomyocyte cAMP microdomains which occur in compensated cardiac hypertrophy and chronic heart failure. Finally, future research directions and translational perspectives are briefly discussed.

  7. FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells.

    Science.gov (United States)

    Börner, Sebastian; Schwede, Frank; Schlipp, Angela; Berisha, Filip; Calebiro, Davide; Lohse, Martin J; Nikolaev, Viacheslav O

    2011-04-01

    Real-time measurements of second messengers in living cells, such as cAMP, are usually performed by ratiometric fluorescence resonance energy transfer (FRET) imaging. However, correct calibration of FRET ratios, accurate calculations of absolute cAMP levels and actual permeabilities of different cAMP analogs have been challenging. Here we present a protocol that allows precise measurements of cAMP concentrations and kinetics by expressing FRET-based cAMP sensors in cells and modulating them with an inhibitor of adenylyl cyclase activity and a cell-permeable cAMP analog that fully inhibits and activates the sensors, respectively. Using this protocol, we observed different basal cAMP levels in primary mouse cardiomyocytes, thyroid cells and in 293A cells. The protocol can be generally applied for calibration of second messenger or metabolite concentrations measured by FRET, and for studying kinetics and pharmacological properties of their membrane-permeable analogs. The complete procedure, including cell preparation and FRET measurements, takes 3-6 d. PMID:21412271

  8. It's a Small World, after All: A Look at Camp around the World.

    Science.gov (United States)

    Nicodemus, Teresa

    2000-01-01

    Camping in Malaysia, New Zealand, England, Brazil, and the United States is compared. The basic function of camp, providing a safe place for fun and discovery, seems universal. Differences discussed include camping seasons, family participation, recreational versus educational emphasis, the competitive nature of for-profit camps, and risk…

  9. 49 CFR 218.75 - Methods of protection for camp cars.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Methods of protection for camp cars. 218.75... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Occupied Camp Cars § 218.75 Methods of protection for camp cars. When camp cars requiring protection are on either main...

  10. Conditions that alter intracellular cAMP levels affect expression of the cAMP phosphodiesterase gene in Dictyostelium.

    OpenAIRE

    Riley, B B; Barclay, S L

    1990-01-01

    We examined expression of the Dictyostelium cAMP phosphodiesterase (PDE) gene under conditions that alter intracellular cAMP levels during in vitro differentiation of wild-type strain V12M2 and a sporogenous derivative, HB200. In control cultures, cellular PDE activity peaked at 6 hr and declined by 8 hr, while secreted PDE activity continued to increase through 8 hr. Lowering intracellular cAMP levels with caffeine or progesterone increased cellular and secreted PDE activities 2-fold, increa...

  11. Cardiac cAMP: production, hydrolysis, modulation and detection

    Directory of Open Access Journals (Sweden)

    Cédric eBOULARAN

    2015-10-01

    Full Text Available Cyclic adenosine 3’,5’-monophosphate (cAMP modulates a broad range of biological processes including the regulation of cardiac myocyte contractile function where it constitutes the main second messenger for β-adrenergic receptors’ signaling to fulfill positive chronotropic, inotropic and lusitropic effects. A growing number of studies pinpoint the role of spatial organization of the cAMP signaling as an essential mechanism to regulate cAMP outcomes in cardiac physiology. Here, we will briefly discuss the complexity of cAMP synthesis and degradation in the cardiac context, describe the way to detect it and review the main pharmacological arsenal to modulate its availability.

  12. The Physics of Quidditch Summer Camp: An Interdisciplinary Approach

    Science.gov (United States)

    Hammer, Donna; Uher, Tim

    The University of Maryland Physics Department has developed an innovative summer camp program that takes an interdisciplinary approach to engaging and teaching physics. The Physics of Quidditch Camp uniquely sits at the intersection of physics, sports, and literature, utilizing the real-life sport of quidditch adapted from the Harry Potter novels to stimulate critical thinking about real laws of physics and leaps of imagination, while actively engaging students in learning the sport and discussing the literature. Throughout the camp, middle school participants become immersed in fun physics experiments and exciting physical activities, which aim to build and enhance skills in problem-solving, analytical thinking, and teamwork. This camp has pioneered new ways of teaching physics to pre-college students, successfully engaged middle school students in learning physics, and grown a large demand for such activities.

  13. Camp as a Teaching Method in Health Education

    DEFF Research Database (Denmark)

    Ringby, Betina

    professionals. New learning methods are required to develop new skills. Health students must develop skills that enable them to create, develop and take action upon new services in new or existing organizations. Aim To investigate if CAMP as a learning method can contribute to didactic development in health...... education to support students in gaining innovative and entrepreneurial skills. Participants A total of 33 physiotherapist students each participated in one of three CAMPS of 48, 24 or 12 hours in an elective module named “Sport, innovation and entrepreneurship”. Methods The project was based on case...... Progression Model’ served as background theory. Evaluation Three different camps were evaluated by students in 2012 and 2013. A written individual evaluation form was filled in at the end of CAMP one; two and three. Data consisted of descriptive questionnaires with open answer alternatives. Evaluations were...

  14. Building a Successful Middle School Outreach Effort: Microscopy Camp

    Science.gov (United States)

    Penn, Lee R.; Flynn, Leslie; Johnson, Page

    2007-01-01

    Microscopy Camp program is designed to introduce acceptable representations of crystalline particles and their atomic structure to twelve-year-old middle school students at a developmental and educational stage.

  15. Thinking Big for 25 Years: Astronomy Camp Research Projects

    Science.gov (United States)

    Hooper, Eric Jon; McCarthy, D. W.; Benecchi, S. D.; Henry, T. J.; Kirkpatrick, J. D.; Kulesa, C.; Oey, M. S.; Regester, J.; Schlingman, W. M.; Camp Staff, Astronomy

    2013-01-01

    Astronomy Camp is a deep immersion educational adventure for teenagers and adults in southern Arizona that is entering its 25th year of existence. The Camp Director (McCarthy) is the winner of the 2012 AAS Education Prize. A general overview of the program is given in an accompanying contribution (McCarthy et al.). In this presentation we describe some of the research projects conducted by Astronomy Camp participants over the years. Many of the Camps contain a strong project-oriented emphasis, which reaches its pinnacle in the Advanced Camps for teenagers. High school students from around the world participate in a microcosm of the full arc of astronomy research. They plan their own projects before the start of Camp, and the staff provide a series of "key projects." Early in the Camp the students submit observing proposals to utilize time on telescopes. (The block of observing time is secured in advance by the staff.) The participants collect, reduce and analyze astronomical data with the help of staff, and they present the results to their peers on the last night of Camp, all in a span of eight days. The Camps provide research grade telescopes and instruments, in addition to amateur telescopes. Some of the Camps occur on Kitt Peak, where we use an ensemble of telescopes: the 2.3-meter (University of Arizona) with a spectrograph; the WIYN 0.9-meter; the McMath-Pierce Solar Telescope; and the 12-meter millimeter wave telescope. Additionally the Camp has one night on the 10-meter Submillimeter Telescope on Mt. Graham. Campers use these resources to study stars, galaxies, AGN, transiting planets, molecular clouds, etc. Some of the camper-initiated projects have led to very high level performances in prestigious international competitions, such as the Intel International Science and Engineering Fair. The key projects often contribute to published astronomical research (e.g., Benecchi et al. 2010, Icarus, 207, 978). Many former Campers have received Ph.D. degrees in

  16. EduCamp Colombia: Social Networked Learning for Teacher Training

    OpenAIRE

    Diego Ernesto Leal Fonseca

    2011-01-01

    This paper describes a learning experience called EduCamp, which was launched by the Ministry of Education of Colombia in 2007, based on emerging concepts such as e-Learning 2.0, connectivism, and personal learning environments. An EduCamp proposes an unstructured collective learning experience, which intends to make palpable the possibilities of social software tools in learning and interaction processes while demonstrating face-to-face organizational forms that reflect social networked lear...

  17. Inside the tent: Community and government in refugee camps

    OpenAIRE

    Bulley, Dan

    2014-01-01

    Refugee camps are increasingly managed through a liberal rationality of government similar to that of many industrialized societies, with security mechanisms being used to optimize the life of particular refugee populations. This governmentality has encompassed programmes introduced by the United Nations High Commissioner for Refugees (UNHCR) and various non-governmental organizations (NGOs) to build and empower communities through the spatial technology of the camp. The present article argue...

  18. Science and technology camp for girls. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-31

    This document reports on the success of Pacific University`s camp held during the summers of 1992 and 1993; ultimate goal of this summer day camp was to increase the number of women in technical and scientific fields. Some experimentation was done with the age groups (7th and 8th grade girls). The curriculum was biology, chemistry, physics, and mathematics/computer science. Laboratory work and field trips were emphasized, along with socialization.

  19. Klambi Lurik Compang-Camping: Sebuah Komposisi Karawitan

    Directory of Open Access Journals (Sweden)

    SUHARDJONO -

    2013-11-01

    Full Text Available Klambi Lurik Compang-Camping Karawitan Composition. This article discusses the creation process ofKlambi Lurik Compang Camping karawitan composition. This composition is inspired by Jineman Klambi Lurik,penned by Wasiran –a traditional artist and teaching staff in Karawitan study programme in ISI Yogyakarta. Thisjineman is favoured by both laypeople and karawitan traditional artists. This composition consists of eight parts,united as one full composition. The creation methods are exploration, improvisation, and shaping.

  20. Social Meaning of Culture in a Stalinist Prison Camp

    Directory of Open Access Journals (Sweden)

    Aimar Ventsel

    2014-04-01

    Full Text Available The Stalinist prison camp system – popularly known as the Gulag archipelago – existed for a relatively short period (from 1931–1960 and became world famous as a synonym for terror, humiliation and human suffering. This article focuses on the social significance of culture in one of the biggest Stalinist prison camp – Karlag in Central Kazakhstan. The first part of the article gives an overview of the institutions of culture in prison camps and their activities. It also gives an overview of unofficial cultural activities and the consequences of being engaged in the unsanctioned creation of art. In the second part of the paper, the social significance of culture in Stalinist prison camps is discussed. Official and non-official art were not separate and existed in symbiosis: people crossed the border between these spheres. Moreover, the camp administration recognised the material value of art produced in the camp and began to organise the production of pictures or handicrafts in order to sell them outside the camp. Nevertheless, both official and unofficial cultures had a deep social meaning for the people. Producing unsanctioned paintings and other objects of artistry can be seen as an act of resistance, producing sanctioned art helped the artists to create their own social and mental space and distance themselves from the everyday grind of the camp. In general, culture and its institutions in the prison failed to fulfill their original purpose – instead of re-educating and changing inmates, culture helped to maintain human dignity and integrity.

  1. Students' Perceptions of the Long-Term Impact of Attending a "CSI Science Camp"

    Science.gov (United States)

    Yanowitz, Karen L.

    2016-07-01

    A science summer camp is a popular type of informal science experience for youth. While there is no one model of a science camp, these experiences typically allow for more focused and in-depth exploration of different science domains and are usually hands-on and participatory. The goal of this research was to examine the impact of a short science camp program approximately 1 year after students attended the camp. Overall, the results revealed that attending a 2-day forensic science camp had a positive and continuing influence on the participants. Students' science self-efficacy increased immediately after attending the camp and remained higher than pre-camp levels approximately 1 year later. Students were able to articulate why they believed the camp had a long-term impact on their lives. Furthermore, participants attributed a higher level of engaging in additional informal STEM-related activities during the academic year as a result of attending the camp.

  2. Characterization of the binding of cAMP and cGMP to the CRP*598 mutant of the E. coli cAMP receptor protein.

    OpenAIRE

    Ren, Y. L.; Garges, S; Adhya, S; Krakow, J. S.

    1990-01-01

    Wild type cAMP receptor protein (CRP) activates in vitro lac transcription only in the presence of cAMP. In contrast the mutant CRP*598 (Arg-142 to His, Ala-144 to Thr) can activate lac transcription in the absence of cyclic nucleotide or at concentrations of cAMP below that required by CRP. To further characterize the properties of CRP*598, the binding of cAMP and cGMP to CRP and CRP*598 has been determined. The intrinsic binding constant (K) values obtained for cAMP binding are: CRP, 1.9 x ...

  3. Direct Light-up of cAMP Derivatives in Living Cells by Click Reactions

    Directory of Open Access Journals (Sweden)

    Yan Xu

    2013-10-01

    Full Text Available 8-Azidoadenosine 3′,5′-cyclic monophosphate (8-azido cAMP was directly detected in living cells, by applying Cu-free azide-alkyne cycloaddition to probe cAMP derivatives by fluorescence light-up. Fluorescence emission was generated by two non-fluorescent molecules, 8-azido cAMP as a model target and difluorinated cyclooctyne (DIFO reagent as a probe. The azide-alkyne cycloaddition reaction between 8-azido cAMP and DIFO induces fluorescence in 8-azido cAMP. The fluorescence emission serves as a way to probe 8-azido cAMP in cells.

  4. Investigation of Sylvatic Typhus at a Wilderness Camp

    Centers for Disease Control (CDC) Podcasts

    2009-06-30

    In this podcast, Dr. Greg Dasch discusses an outbreak of four cases of sylvatic typhus that occurred at a wilderness camp in Pennsylvania. Sylvatic typhus is very rare in the United States, with only 41 cases since it was discovered in the United States in 1975. Lab work at CDC and the discovery that all four camp counselors who became ill had slept in the same bunk at the camp between 2004 and 2006 ultimately led to confirmation that flying squirrels living in the wall of the cabin were to blame for the illnesses.  Created: 6/30/2009 by Emerging Infectious Diseases.   Date Released: 6/30/2009.

  5. Science Camp - lystigt eller lærerigt

    DEFF Research Database (Denmark)

    Ahrenkiel, Linda; Albrechtsen, Thomas S. R.

    2013-01-01

    I oplægget vil vi undersøge fænomenet Science Camps nærmere ved at fortælle om dets historiske udvikling og ikke mindst lægge op til en diskussion af en definition. Derudover vil vi præsentere en case, hvor der med udgangspunkt i et aktuelt ph.d.-projekt er blevet undersøgt, hvad deltagerne får ud...... af at deltage i en science camp: Kan man både vække begejstring og medvirke til læring?...

  6. EduCamp Colombia: Social Networked Learning for Teacher Training

    Directory of Open Access Journals (Sweden)

    Diego Ernesto Leal Fonseca

    2011-03-01

    Full Text Available This paper describes a learning experience called EduCamp, which was launched by the Ministry of Education of Colombia in 2007, based on emerging concepts such as e-Learning 2.0, connectivism, and personal learning environments. An EduCamp proposes an unstructured collective learning experience, which intends to make palpable the possibilities of social software tools in learning and interaction processes while demonstrating face-to-face organizational forms that reflect social networked learning ideas. The experience opens new perspectives for the design of technology training workshops and for the development of lifelong learning experiences.

  7. Science Skills Boot Camp Gets Interns Ready for Research | Poster

    Science.gov (United States)

    By Ashley DeVine, Staff Writer Summer interns learned how to read a scientific paper, present a poster, maintain a laboratory notebook, and much more, at the Science Skills Boot Camp in June. “It was a great experience, and it was a great opportunity to meet some of the other interns also working on the campus,” said Alyssa Klein, a Werner H. Kirsten student intern in the Cellular Immunology Group, Laboratory of Molecular Immunoregulation. “The boot camp covered many topics essential to being a good scientist and science researcher.”

  8. Promoting independence in adolescent paraplegics: a 2-week "camping" experience.

    Science.gov (United States)

    Bodzioch, J; Roach, J W; Schkade, J

    1986-01-01

    In the summer of 1982, Texas Scottish Rite Hospital (Dallas, TX, U.S.A.) sponsored a camp for paraplegic adolescents. Six patients, three boys and three girls 14-17 years of age, participated in a 2-week program that was designed to improve their self-esteem, independence, and eventual employability. In their pre- and postcamp psychological evaluations, the campers demonstrated improvement in social skills and self-concept testing as compared with the scores of a matched control group, although this improvement did not reach statistical significance. We believe the camp was immensely successful, an opinion that was shared by both the campers and their parents. PMID:3514667

  9. 77 FR 25952 - Oregon Army National Guard, Camp Rilea, Clatsop County, OR; Danger Zone

    Science.gov (United States)

    2012-05-02

    ... boundaries of the Camp. If a vessel is detected in the danger zone, a cease fire will be called on all active weapons ranges and Camp Rilea will attempt to contact the vessel using marine VHF radio. Cease fire...

  10. Seafloor Science and Remotely Operated Vehicle (SSROV) Day Camp: A Week-Long, Hands-On STEM Summer Camp

    Science.gov (United States)

    Wheat, C. G.; Fournier, T.; Monahan, K.; Paul, C.

    2015-12-01

    RETINA (Robotic Exploration Technologies IN Astrobiology) has developed a program geared towards stimulating our youth with innovative and relevant hands-on learning modules under a STEM umbrella. Given the breadth of potential science and engineering topics that excite children, the RETINA Program focuses on interactive participation in the design and development of simple robotic and sensor systems, providing a range of challenges to engage students through project-based learning (PBL). Thus, young students experience scientific discovery through the use and understanding of technology. This groundwork serves as the foundation for SSROV Camp, a week-long, summer day camp for 6th-8th grade students. The camp is centered on the sensors and platforms that guide seafloor exploration and discovery and builds upon the notion that transformative discoveries in the deep sea result from either sampling new environments or making new measurements with sensors adapted to this extreme environment. These technical and scientific needs are folded into the curriculum. Each of the first four days of the camp includes four team-based, hands-on technical challenges, communication among peer groups, and competition. The fifth day includes additional activities, culminating in camper-led presentations to describe a planned mission based on a given geologic setting. Presentations include hypotheses, operational requirements and expected data products. SSROV Camp was initiated last summer for three sessions, two in Monterey, CA and one in Oxford, MS. Campers from both regions grasped key elements of the program, based on written responses to questions before and after the camp. On average, 32% of the pre-test questions were answered correctly compared with 80% of the post-test questions. Additional confirmation of gains in campers' knowledge, skills, and critical thinking on environmental issues and engineering problems were apparent during the "jeopardy" competition, nightly homework

  11. Residential summer camp: a new venue for nutrition education and physical activity promotion

    OpenAIRE

    Ventura, Alison K.; Garst, Barry A

    2013-01-01

    Background Millions of children attend residential summer camps each year. However, few studies have examined the potential of camps for obesity prevention efforts. Research in the domain of positive youth development has shown that camp programs as short as one week have both short- and long-term positive effects on self-esteem, self-efficacy and other youth outcomes. The objective of the present study was to highlight the potential of resident camps as promising venues for the promotion of ...

  12. Synergies in Marketing Management in Camping Tourism on the Slovenian Adriatic Coast

    OpenAIRE

    Bojnec, Štefan; Drakulić, Martina

    2012-01-01

    Purpose - The purpose is to investigate synergies in marketing management in camping tourism to properly understand the perceived client behaviour. Design/methodology/approach - Camping tourism is investigated by using secondary data and the perceived client behaviour by using the primary collected evidence from the interviews and surveys. Findings - The popularity of camping tourism in Slovenia is increasing among foreign tourists. Camping tourism is more significant in accommodation capacit...

  13. An Exploration of Developed Forest Camping Experiences and Meanings in the Mount Rogers National Recreation Area

    OpenAIRE

    Garst, Barry Austin

    2005-01-01

    Developed forest camping has received little attention in the recreation research since the late 1960s and early 1970s. Changes in socio-demographics, technology, and the publicâ s expectations for amenities over the past forty years suggested that the nature of the developed camping experience may have changed. Thus, the purpose of this study was to understand the modern developed forest camping experience and associated meanings and the influence of technology on developed forest camping...

  14. Reflections on Refugee Students' Major Perceptions of Education in Kakuma Refugee Camp, Kenya

    Science.gov (United States)

    Mareng, Chuei D.

    2010-01-01

    This reflective study explores refugee students' perceptions of the educational approach used in Kakuma Refugee Camp in Kenya. The study focuses on my personal reflections as a teacher and a student in this camp, and as a refugee. My goal of writing this narrative is to reflect fully on the refugee students' life in a camp and then contribute to…

  15. Hack City Summer: Computer Camps Can Bring a Vacation of Keyboard Delights.

    Science.gov (United States)

    Shell, Ellen Ruppel

    1983-01-01

    Activities at a summer computer camp (Camp Atari held at East Stroudsburg State College PA) are described. The curriculum, using logic, systematic analysis, and other fundamental programing skills, teaches students to interact effectively and creatively with computers. Sources for finding a computer camp are included. (JN)

  16. A Multidisciplinary Science Summer Camp for Students with Emphasis on Environmental and Analytical Chemistry

    Science.gov (United States)

    Schwarz, Gunnar; Frenzel, Wolfgang; Richter, Wolfgang M.; Ta¨uscher, Lothar; Kubsch, Georg

    2016-01-01

    This paper presents the course of events of a five-day summer camp on environmental chemistry with high emphasis on chemical analysis. The annual camp was optional and open for students of all disciplines and levels. The duration of the summer camp was five and a half days in the Feldberg Lake District in northeast Germany (federal state of…

  17. Strengthening Families: Exploring the Impacts of Family Camp Experiences on Family Functioning and Parenting

    Science.gov (United States)

    Garst, Barry A.; Baughman, Sarah; Franz, Nancy K.; Seidel, Richard W.

    2013-01-01

    Research suggests that family camp experiences can enhance family relationships. Families often participate in family camp experiences for a vacation, as part of a therapeutic and/or intervention strategy, or to gain general enrichment or engagement. To better understand the impacts of family camp experiences on family functioning, a mixed-methods…

  18. Culture Camp, Ethnic Identity, and Adoption Socialization for Korean Adoptees: A Pretest and Posttest Study

    Science.gov (United States)

    Baden, Amanda L.

    2015-01-01

    This study explores the impact of racial-ethnic socialization on adopted South Korean children and adolescents who attended a sleepaway Korean culture camp for one week. This camp provided racial-ethnic socialization experiences via exposure to camp counselors, staff, and teachers who were Korean Americans, Korean nationals, and Korean adult…

  19. The accidental city : violence, economy and humanitarianism in Kakuma refugee camp Kenya

    NARCIS (Netherlands)

    Jansen, B.J.

    2011-01-01

    In this research I examine social ordering processes in Kakuma refugee camp in Kenya. I view the camp as an accidental city, by which I challenge the image of the camp as a temporary and artificial waiting space or a protracted refugee crisis per se. The reference to the city is both metaphorical

  20. 76 FR 64 - Safety and Health Requirements Related to Camp Cars

    Science.gov (United States)

    2011-01-03

    ... Guidelines for Clean, Safe, and Sanitary Railroad Provided Camp Cars (1990 Guidelines), 55 FR 30892, July 27... Camp Cars AGENCY: Federal Railroad Administration (FRA), Department of Transportation (DOT). ACTION... is proposing to create regulations prescribing minimum safety and health requirements for camp...

  1. 76 FR 67073 - Safety and Health Requirements Related to Camp Cars

    Science.gov (United States)

    2011-10-31

    ... Camp Cars AGENCY: Federal Railroad Administration (FRA), Department of Transportation (DOT). ACTION... prescribing minimum safety and health requirements for camp cars that a railroad provides as sleeping quarters... hazardous material, of a camp car that is occupied exclusively by individuals employed to maintain...

  2. OUTBREAK OF NORWALK-RELATED GASTROENTERITIS AT A BOYS' CAMP

    Science.gov (United States)

    An acute gastrointestinal illness affected 213 (52%) of 407 campers and 64 (52%) of 121 staff attending a boy's camp in the Catoctin Mountains of Maryland during the summer of 1981. Nausea was the predominant symptom for ill campers and staff (73%), but more staff members experie...

  3. Criticality for Global Citizenship in Korean English Immersion Camps

    Science.gov (United States)

    Ahn, So-Yeon

    2015-01-01

    Given a heavy social, ideological pressure for parents to pursue better English education for their children in the globalized world, short-term English immersion camp programs have emerged as an educational option in South Korea, promoted as environments for intercultural communication between native English-speaking teachers and local Korean…

  4. Vietnamese in America, Part Four: Life in the Refugee Camps

    Science.gov (United States)

    Liu, William T.; Murata, Alice K.

    1978-01-01

    The experiences of Vietnamese refugees in transitional camps in the summer and fall of 1975 are described in this paper. The data show that the mental health needs of the refugees were not taken seriously and that it was assumed that assimilation would be problem-free. (Author/AM)

  5. 14 CFR 91.1415 - CAMP: Mechanical reliability reports.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false CAMP: Mechanical reliability reports. 91.1415 Section 91.1415 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... certificate (including a supplemental type certificate), a Parts Manufacturer Approval, or a...

  6. 14 CFR 91.1441 - CAMP: Transfer of maintenance records.

    Science.gov (United States)

    2010-01-01

    ... Ownership Operations Program Management § 91.1441 CAMP: Transfer of maintenance records. When a U.S... aircraft in the management specifications, the program manager must transfer to the purchaser, at the time of the sale, the following records of that aircraft, in plain language form or in coded form...

  7. Gender Differences in the Perceived Severity of Boot Camp

    Science.gov (United States)

    Wood, Peter B.; May, David C.; Grasmick, Harold G.

    2005-01-01

    We analyze survey data from 181 male and 224 female inmates serving brief prison terms for nonviolent offenses to examine offenders' perceptions of the severity of boot camp compared to prison. Building on the limited work in this area, we present reasons those offenders feel are important to both avoid and participate in alternative sanctions.…

  8. Hiring Counselors: Steps to Finding Good Camp Staff.

    Science.gov (United States)

    Brockman, Robert A.

    1990-01-01

    Describes favorable practices for hiring outdoor summer camp counselors. Offers tips for looking at resumes and applications. Describes interview process and suggests interview questions for understanding applicants' motivation, maturity, and sense of responsibility. Emphasizes counselor as campers' teacher, leader, friend, and role model. (TES)

  9. Phun Physics 4 Phemales: Physics Camp for High School Girls

    Science.gov (United States)

    Kwon, Chuhee; Gu, Jiyeong; Henriquez, Laura

    2014-03-01

    The department of Physics and Astronomy with the department of Science Education at California State University, Long Beach hosted summer program of ``Phun Physics 4 Phemales (PP4P)'' during summer 2012 and summer 2013 with the support from APS public outreach program. PP4P summer camp was hosted along with a two-week summer science camp, Young Scientists Camp, which has been institutionalized for the last 14 years since 1999. More than 2,500 3rd -8th grade students and 250 teachers have participated in the program. PP4P program provided the tools and support that female high school students need to pursue careers in physics and/or science, technology, engineering and math (STEM) field. This girls-only camp created connections among the girls and built confidence. In addition PP4P program introduced students to key principles in physics by a hands-on lab environment and demonstrated the real-world social impact of physics. In summer 2012, high school girls worked on physics experimental project on electronics and in summer 2013 they worked on the mechanics. I would share our experience in this program and the impact on the female high school students. This work was supported by 2012 Public Outreach and Informing the Public Grants from American Physical Society.

  10. Academic Boot Camp for the Writing of Psychology Research Reports

    Science.gov (United States)

    Skues, Jason L.; Wise, Lisa

    2014-01-01

    Herein, we describe the implementation of, and responses to, a structured writing workshop in the form of an academic boot camp. Participants were 42 undergraduate psychology students from a medium-sized Australian university who were completing their major assignment for the semester. A majority of the students expressed satisfaction with the…

  11. Meeting the Special Dietary Needs of All Camp Guests.

    Science.gov (United States)

    Spain, Viki Kappel

    2002-01-01

    More and more people are making personal or doctor-advised dietary changes, and camp kitchen staff must be happy and willing to provide alternative foods. Reasons for being a vegetarian, vegetarian foods, nutrition concerns in the vegetarian diet, and tips for preparing meatless dishes are discussed. Sidebars present indepth information on special…

  12. 29 CFR 1910.142 - Temporary labor camps.

    Science.gov (United States)

    2010-07-01

    ... facilities shall be spaced not closer than 36 inches both laterally and end to end, and shall be elevated at... inches both laterally and end to end. The minimum clear space between the lower and upper bunk shall be... such installations. If a camp is used during cold weather, adequate heating equipment shall be...

  13. Modeling for water penetration into narrow gap in CAMP code

    International Nuclear Information System (INIS)

    An analytical code, CAMP, is being developed at JAERI for thermo-fluiddynamics of a molten core in the lower plenum of the reactor pressure vessel (RPV). Models for the water penetration into narrow gaps based on the flooding of a two-phase flow have been recently incorporated in CAMP code. The in-vessel debris coolability experiments performed at Japan Atomic Energy Research Institute (JAERI), where an Al2O3 melt was poured into a water-filled lower head experimental vessel and the interfacial gap between the solidified Al2O3 and the vessel was supposed to form, were analyzed with CAMP code. It was found that temperature histories at the vessel outer surface were qualitatively reproduced using the water penetration model. The analysis also implied that an appropriate flooding correlation are needed to increase the predictability of CAMP code and that the steam generation in the interfacial gap, which largely influences on the flooding, was dominated by thermal radiation from the surface of the solidified Al2O3 to the penetrating water. (author)

  14. Snakes Have Feelings, Too: Elements of a Camp Snake Program.

    Science.gov (United States)

    Allen, Robert Ross

    2001-01-01

    A camp snake program can help campers overcome their fear of snakes, and people cannot truly enjoy nature when they carry a phobia about any one part of it. It can also help overcome prejudice by teaching truth and respect, instilling compassion, and helping campers develop empathy. Advice on catching, handling, identifying, keeping, and feeding…

  15. Participant Perspectives on the ESO Astronomy Camp Programme

    Science.gov (United States)

    Olivotto, C.; Cenadelli, D.; Gamal, M.; Grossmann, D.; Teller, L. A. I.; Marta, A. S.; Matoni, C. L.; Taillard, A.

    2015-09-01

    This article describes the experience of attending the European Southern Observatory (ESO) Astronomy Camp from the perspective of its participants - students aged between 16 and 18 years old from around the world. The students shared a week together during the winter of 2014 in the Alpine village of Saint-Barthelemy, Italy. The camp was organised by ESO in collaboration with Sterrenlab and the Astronomical Observatory of the Autonomous Region of the Aosta Valley and offered a rich programme of astronomy and leisure activities. This article focuses on the concept of astronomy camps, and their role as a unique tool to complement formal classroom education, rather than on the astronomy activities and the scientific programme. Thus, it is not an academic review of the implemented methodologies, but rather a reflection on the overall experience. The article was brought together from collaborative accounts by some of the participants who were asked to reflect on the experience. The participants who contributed to this article represent the diversity of the ESO Astronomy Camp's alumni community.

  16. Credit-based livelihood interventions in a Zambian refugee camp

    Directory of Open Access Journals (Sweden)

    Jane Travis

    2004-05-01

    Full Text Available Establishing community credit facilities has become an important developmental tool for building livelihood strategies. In the refugee camps where the British NGO Christian Outreach Relief andDevelopment (CORD has worked, programmes have provided credit in the form of cash, agricultural inputs or livestock.

  17. Camp stability predicts patterns of hunter–gatherer cooperation

    Science.gov (United States)

    2016-01-01

    Humans regularly cooperate with non-kin, which has been theorized to require reciprocity between repeatedly interacting and trusting individuals. However, the role of repeated interactions has not previously been demonstrated in explaining real-world patterns of hunter–gatherer cooperation. Here we explore cooperation among the Agta, a population of Filipino hunter–gatherers, using data from both actual resource transfers and two experimental games across multiple camps. Patterns of cooperation vary greatly between camps and depend on socio-ecological context. Stable camps (with fewer changes in membership over time) were associated with greater reciprocal sharing, indicating that an increased likelihood of future interactions facilitates reciprocity. This is the first study reporting an association between reciprocal cooperation and hunter–gatherer band stability. Under conditions of low camp stability individuals still acquire resources from others, but do so via demand sharing (taking from others), rather than based on reciprocal considerations. Hunter–gatherer cooperation may either be characterized as reciprocity or demand sharing depending on socio-ecological conditions. PMID:27493770

  18. Novel H1N1 Flu and Camp

    Centers for Disease Control (CDC) Podcasts

    2009-06-30

    This podcast gives tips to stay healthy and help prevent infection with novel H1N1 flu if your child or someone you know is going to camp.  Created: 6/30/2009 by Centers for Disease Control and Prevention (CDC).   Date Released: 6/30/2009.

  19. Evaluating the Effectiveness of the General Surgery Intern Boot Camp.

    Science.gov (United States)

    Schoolfield, Clint S; Samra, Navdeep; Kim, Roger H; Shi, Runhua; Zhang, Wayne W; Tan, Tze-Woei

    2016-03-01

    The aim of our study is to evaluate the effectiveness of newly implemented general surgery intern boot camp. A 2-day didactic and skills-based intern boot camp was implemented before the start of clinical duties. Participants who did not attend all boot camp activities and had prior postgraduate training were excluded. A survey utilizing a 5-point Likert scale scoring system was used to assess the participants' confidence to perform intern-level tasks before and after the boot camp. Subgroup analyses were performed comparing changes in confidence among graduates from home institution versus others and general surgery versus other subspecialties. In the analysis, 21 participants over two years were included. Among them, 7 were graduates from home institution (4 general surgery, 3 subspecialty) and 14 were from other institutions (6 general surgery and 8 subspecialty). There were significant increases in overall confidence levels (pre = 2.79 vs post = 3.43, P interpersonal skills and communication (3.04 vs 3.53, P = 0.001), and practice-based learning (2.65 vs 3.41, P = 0.001). There was an improvement in confidence level for both home institution graduates (2.89 vs 3.53, P = 0.022) and other graduates (2.74 vs 3.34, P < 0.001). Similarly, participants from general surgery (2.78 vs 3.46, P = 0.001) and other specialties (2.74 vs 3.34, P < 0.001) reported significant improvement in confidence. General surgery intern boot camp before the start of official rotation is effective in improving confidence level in performing level-appropriate tasks of the incoming new interns. PMID:27099061

  20. Using Science Camps to Develop Understandings about Scientific Inquiry--Taiwanese Students in a U.S. Summer Science Camp

    Science.gov (United States)

    Antink-Meyer, Allison; Bartos, Stephen; Lederman, Judith S.; Lederman, Norman G.

    2016-01-01

    Recent years have witnessed a dramatic rise in the number of middle and high school students from Asian countries participating in U.S.-based summer experiences (Perlez & Gao, 2013). Although summer science camps have been shown to improve students' attitudes and interests related to science and science learning (Bhattacharyya, Mead &…

  1. Multiple Facets of cAMP Signalling and Physiological Impact: cAMP Compartmentalization in the Lung

    Directory of Open Access Journals (Sweden)

    Martina Schmidt

    2012-11-01

    Full Text Available Therapies involving elevation of the endogenous suppressor cyclic AMP (cAMP are currently used in the treatment of several chronic inflammatory disorders, including chronic obstructive pulmonary disease (COPD. Characteristics of COPD are airway obstruction, airway inflammation and airway remodelling, processes encompassed by increased airway smooth muscle mass, epithelial changes, goblet cell and submucosal gland hyperplasia. In addition to inflammatory cells, airway smooth muscle cells and (myofibroblasts, epithelial cells underpin a variety of key responses in the airways such as inflammatory cytokine release, airway remodelling, mucus hypersecretion and airway barrier function. Cigarette smoke, being next to environmental pollution the main cause of COPD, is believed to cause epithelial hyperpermeability by disrupting the barrier function. Here we will focus on the most recent progress on compartmentalized signalling by cAMP. In addition to G protein-coupled receptors, adenylyl cyclases, cAMP-specific phospho-diesterases (PDEs maintain compartmentalized cAMP signalling. Intriguingly, spatially discrete cAMP-sensing signalling complexes seem also to involve distinct members of the A-kinase anchoring (AKAP superfamily and IQ motif containing GTPase activating protein (IQGAPs. In this review, we will highlight the interaction between cAMP and the epithelial barrier to retain proper lung function and to alleviate COPD symptoms and focus on the possible molecular mechanisms involved in this process. Future studies should include the development of cAMP-sensing multiprotein complex specific disruptors and/or stabilizers to orchestrate cellular functions. Compartmentalized cAMP signalling regulates important cellular processes in the lung and may serve as a therapeutic target.

  2. Musik in Konzentrationslagern The Role of Music in Concentration Camps

    Directory of Open Access Journals (Sweden)

    Gabriele Knapp

    2002-03-01

    Full Text Available Die Holocaust-Forschung hat sich jahrzehntelang vorwiegend mit den Verbrechen in den Konzentrationslagern beschäftigt, während Fragen nach dem „Alltag“ der Häftlinge und ihren Strategien des Überlebens nebensächlich erschienen. Untersuchungen zum (ÜberLeben im KZ können aber gerade die Brutalität des Systems deutlich machen. So war Musik ein integraler Bestandteil des Lageralltags und diente keineswegs nur der Erbauung der Häftlinge, sondern bedeutete für sie häufig eine zusätzliche Tortur, wie Forschungsarbeiten für die Zeit von 1939 bis 1945 bereits belegt haben. Inwieweit dies für die frühen Lager von 1933 bis 1936 zutraf, untersucht Guido Fackler in seiner Studie. Darüber hinaus versucht er, musikalische Kontinuitätslinien von den frühen Lagern bis in die späte Phase (1937–1945 zu zeichnen. Eine Gesamtdarstellung zu KZ-Musik von 1933 bis 1945 konnte dem Autor indes nicht gelingen, wenn er auch einzelne Zusammenhänge zwischen musikalischen Phänomenen in unterschiedlichen Lagern aufzeigt. Facklers Buch lässt sich eher als Quellensammlung für Musik in unterschiedlichsten Konzentrationslagern verstehen und gebrauchen – wenn auch fast ausschließlich begrenzt auf Männerlager.In the past decades, Holocaust studies have focused on researching the annihilating structures of concentration camps, while the study of the inmates’ everyday lives and their strategies for survival was not included in this field of work. However, studying aspects of daily life and survival in the concentration camps can serve to truly bring out the brutality of the Holocaust. Music, for example, was an integral part of everyday life in the camps and did not solely serve to entertain the inmates, but also represented an additional form of torture for them, as previous studies for the time period between 1939 and 1945 have documented. Fackler’s study investigates the extent to which this was the case in the early concentration camps between

  3. [Dental practice in the camps of the Third Reich].

    Science.gov (United States)

    Riaud, Xavier

    2003-01-01

    In the Concentration Camps, the Nazis made a mixing of National Socialism ideology, anti-Semitism and war effort. After the arrival of trains in the camps the Nazis selected the weakest inmates for the gas chambers, as far as they considered them to be "useless mouths". The heathly grownups were kept for productive use. However a person suffering from bad tooth was not profitable. Thus some inmate dentists were in position to give dental cares to a few prisoners as they had been allowed by the Nazis to work in precarious circumstances. On the 23rd of September 1940 Himmler ordered to pull out the dental gold from the alive prisoners or at their exit of gas chambers. The decree was reinforced on the 23rd December 1942. The product of gold became a mean to support war effort. On the other hand few dental experiments have been performed by the SS doctors. PMID:12959116

  4. From camp to kitsch: A queer eye on console fandom

    Directory of Open Access Journals (Sweden)

    Rob Gallagher

    2014-03-01

    Full Text Available Offering a queer perspective on video game fandom, this article considers the factors that fostered a subculture of Western devotees of Japanese video games in the 1990s. Focused on readers of the English publication Sega Saturn Magazine, it shows how, for these players, Japanese games became the basis of a collective identity founded on precisely the kinds of perverse over-attachment, projective identification and hermeneutic ingenuity that Eve Kosofsky Sedgwick identifies with camp. Citing this subculture as an example of how fans transform the texts they put to use, the article also addresses its implications for our understanding of fandom today, at a time when the proliferation of quantitative analysis techniques is transforming the production and consumption of games. Such techniques, I argue, threaten to compromise the contingency and ambiguity on which camp thrives, instead fostering the kinds of cynical calculation Sedgwick associates with kitsch.

  5. CORRECTIVE SURGERY IN CONGENITAL TALIPES EQUINOVARUS DEFORMITY: A CAMP APPROACH

    Directory of Open Access Journals (Sweden)

    Antony R.

    2015-09-01

    Full Text Available The study was intended to assess the results of soft tissue release and bony corrective surgery in patients of moderate to severe deformed rigid club foot (CTEV and neglected clubfoot (CTEV at free disabled surgical camps at Chhattisgarh state . MATERIAL AND METHODS : In our study 50 patients were included with 70% male and 30% female with 4 - 16 years of age grou p and 70% unilateral and 30% bilateral foot involvement. Patients were admitted and operated in different free disabled surgical camps at Chhattisgarh state over the period of 36 months (1 may 2004 to 30 th April 2007. Improvement in functional ability and locomotion of all operated patients were assessed by physical and clinical examination. RESULTS : All patients who were operated in our study showed significant improvement in functional ability and locomotion after surgery. All patients were maintaining f unctional ability at follow up duration of 12 months (1 year. 75% patients were walking normally, 10% cases were walking with internal rotation of leg and 5% cases were walking with midtarsal varus foot with AFO with medial bar support. CONCLUSION : Our st udy showed and established that excellent results can be obtained in congenital talipes equinovarus (CTEV patients by soft tissue release with bony corrective surgery. The team work of devoted surgeons, paramedical and rehabilitation staff in whole durati on of camps to achieve the goal. With an aim to help more number of CTEV cases by surgery, our team has started doing surgeries in small institutions, and organize charity camps to help poor patients and mankind even in small clinics

  6. Collaborative Tools Used to Organize a Library Camp Unconference

    OpenAIRE

    Crossett, Laura; Kraus, Joseph; Lawson, Steve

    2009-01-01

    From July to October, 2008, Laura Crossett, Joseph Kraus and Steve Lawson organized the Library Camp of the West (http://librarycampwest.pbwiki.com/). This was an unconference that took place on October 10, 2008 at the University of Denver. The authors used many technology tools to organize the event, such as email, wikis, blogs, two tools from Google, the Doodle scheduling Website, Flickr and more. This article will explain how they used those tools to prepare for the unconference.

  7. Bore-hole survey at Camp Century, 1989

    DEFF Research Database (Denmark)

    Dahl-Jensen, Dorthe; Gundestrup, NS.; Hansen, BL.; kelty, J.

    1993-01-01

    A combination of the directional surveys of the Camp Century borehole from 1966, 1967, 1969 and 1989 has revealed a deformation pattern similar to that measured at Dye-3, South Greenland and Byrd Station, Antarctica showing high deformation rate for Wisconsin ice. Compared to the Dye-3 profile, t...... deformation shows the same pattern even in details. The surface velocity obtained by integrating the bore hole deformation is in agreement with that obtained from satellite measurements Udgivelsesdato: jan...

  8. Tidal Marsh Vegetation of China Camp, San Pablo Bay, California

    OpenAIRE

    Baye, Peter R.

    2012-01-01

    China Camp (Marin County, California) preserves extensive relict stands of salt marsh vegetation developed on a prehistoric salt marsh platform with a complex sinuous tidal creek network. The low salt marsh along tidal creeks supports extensive native stands of Pacific cordgrass (Spartina foliosa). The outer salt marsh accreted following hydraulic gold mining sedimentation. It consists of a wave-scarped pickleweed-dominated (Sarcocornia pacifica) high salt marsh terrace with a broad fringing ...

  9. Smart and Green Energy (SAGE) for Base Camps Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Engels, Matthias; Boyd, Paul A.; Koehler, Theresa M.; Goel, Supriya; Sisk, Daniel R.; Hatley, Darrel D.; Mendon, Vrushali V.; Hail, John C.

    2014-02-11

    The U.S. Army Logistics Innovation Agency’s (LIA’s) Smart and Green Energy (SAGE) for Base Camps project was to investigate how base camps’ fuel consumption can be reduced by 30% to 60% using commercial off-the-shelf (COTS) technologies for power generation, renewables, and energy efficient building systems. Field tests and calibrated energy models successfully demonstrated that the fuel reductions are achievable.

  10. Camp Pendleton Saves 91% in Parking Lot Lighting

    Energy Technology Data Exchange (ETDEWEB)

    None

    2016-01-01

    Case study describes how Camp Pendleton Marine Corps Base replaced high-pressure sodium (HPS) fixtures in one parking lot with high-efficiency induction fixtures for 91% savings in energy use and $5,700 in cost savings annually. This parking lot is estimated to have a simple payback of 2.9 years. Sitewide up-grades yielded annual savings of 1 million kWh.

  11. Building Energy Audit Report for Camp Smith, HI

    Energy Technology Data Exchange (ETDEWEB)

    Chvala, William D.; De La Rosa, Marcus I.; Brown, Daryl R.; Dixon, Douglas R.

    2010-09-30

    A detailed energy assessment was performed by a team of engineers from Pacific Northwest National Laboratory (PNNL) under contract to the Department of Energy/Federal Energy Management program (FEMP). The effort used the Facility Energy Decision System (FEDS) model to determine how energy is consumed at Camp Smith, identify the most cost-effective energy retrofit measures, and calculate the potential energy and cost savings. This report documents the results of that assessment.

  12. Outbreak of chickenpox in a refugee camp of northern Thailand

    Directory of Open Access Journals (Sweden)

    Camélique Olivier

    2010-02-01

    Full Text Available Abstract Although chickenpox is a generally mild, self-limited illness of children, it can cause fatal disease in adults. Accumulating reports from tropical countries showed a high prevalence of seronegativity among the adults, implying that varicella diseases could become a heavy burden in tropical countries. However, in the situation of humanitarian emergencies in tropical areas, chickenpox has largely been ignored as a serious communicable disease, due to lack of data regarding varicella mortality and hospital admissions in such a context. This is the first report describing an outbreak of chickenpox in a refugee camp of tropical region. In 2008, we experienced a varicella outbreak in ethnic Lao Hmong refugee camp in Phetchabun Province, northern Thailand. The attack rate was 4.0% (309/7,815 and this caused 3 hospitalizations including one who developed severe varicella pneumonia with respiratory failure. All hospitalizations were exclusively seen in adults, and the proportion of patients ≥15 years old was 13.6% (42/309. Because less exposure to varicella-zoster virus due to low population density has previously been suggested to be one of the reasons behind higher prevalence of susceptible adults in tropics, the influx of displaced people from rural areas to a densely populated asylum might result in many severe adult cases once a varicella outbreak occurs. Control interventions such as vaccination should be considered even in refugee camp, if the confluence of the risk factors present in this situation.

  13. Exchange Protein Directly Activated by cAMP (epac) : A Multidomain cAMP Mediator in the Regulation of Diverse Biological Functions

    NARCIS (Netherlands)

    Schmidt, Martina; Dekker, Frank J.; Maarsingh, Harm

    2013-01-01

    Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal and versatile second messengers. The tremendous feature of cAMP to tightly control highly diverse physiologic processes, including calcium homeostasis, metabolism, secretion, muscle contraction, cell fate, and g

  14. Chlorella intake attenuates reduced salivary SIgA secretion in kendo training camp participants

    Directory of Open Access Journals (Sweden)

    Otsuki Takeshi

    2012-12-01

    Full Text Available Abstract Background The green alga Chlorella contains high levels of proteins, vitamins, and minerals. We previously reported that a chlorella-derived multicomponent supplement increased the secretion rate of salivary secretory immunoglobulin A (SIgA in humans. Here, we investigated whether intake of this chlorella-derived supplement attenuated the reduced salivary SIgA secretion rate during a kendo training camp. Methods Ten female kendo athletes participated in inter-university 6-day spring and 4-day summer camps. They were randomized into two groups; one took placebo tablets during the spring camp and chlorella tablets during the summer camp, while the other took chlorella tablets during the spring camp and placebo tablets during the summer camp. Subjects took these tablets starting 4 weeks before the camp until post-camp saliva sampling. Salivary SIgA concentrations were measured by ELISA. Results All subjects participated in nearly all training programs, and body-mass changes and subjective physical well-being scores during the camps were comparable between the groups. However, salivary SIgA secretion rate changes were different between these groups. Salivary SIgA secretion rates decreased during the camp in the placebo group (before vs. second, middle, and final day of camp, and after the camp: 146 ± 89 vs. 87 ± 56, 70 ± 45, 94 ± 58, and 116 ± 71 μg/min, whereas no such decreases were observed in the chlorella group (121 ± 53 vs. 113 ± 68, 98 ± 69,115 ± 80, and 128 ± 59 μg/min. Conclusion Our results suggest that a use of a chlorella-derived dietary supplement attenuates reduced salivary SIgA secretion during a training camp for a competitive sport.

  15. A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation.

    Directory of Open Access Journals (Sweden)

    Pei-Chi Yang

    2016-07-01

    Full Text Available Subcellular compartmentation of the ubiquitous second messenger cAMP has been widely proposed as a mechanism to explain unique receptor-dependent functional responses. How exactly compartmentation is achieved, however, has remained a mystery for more than 40 years. In this study, we developed computational and mathematical models to represent a subcellular sarcomeric space in a cardiac myocyte with varying detail. We then used these models to predict the contributions of various mechanisms that establish subcellular cAMP microdomains. We used the models to test the hypothesis that phosphodiesterases act as functional barriers to diffusion, creating discrete cAMP signaling domains. We also used the models to predict the effect of a range of experimentally measured diffusion rates on cAMP compartmentation. Finally, we modeled the anatomical structures in a cardiac myocyte diad, to predict the effects of anatomical diffusion barriers on cAMP compartmentation. When we incorporated experimentally informed model parameters to reconstruct an in silico subcellular sarcomeric space with spatially distinct cAMP production sites linked to caveloar domains, the models predict that under realistic conditions phosphodiesterases alone were insufficient to generate significant cAMP gradients. This prediction persisted even when combined with slow cAMP diffusion. When we additionally considered the effects of anatomic barriers to diffusion that are expected in the cardiac myocyte dyadic space, cAMP compartmentation did occur, but only when diffusion was slow. Our model simulations suggest that additional mechanisms likely contribute to cAMP gradients occurring in submicroscopic domains. The difference between the physiological and pathological effects resulting from the production of cAMP may be a function of appropriate compartmentation of cAMP signaling. Therefore, understanding the contribution of factors that are responsible for coordinating the spatial and

  16. A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation.

    Science.gov (United States)

    Yang, Pei-Chi; Boras, Britton W; Jeng, Mao-Tsuen; Docken, Steffen S; Lewis, Timothy J; McCulloch, Andrew D; Harvey, Robert D; Clancy, Colleen E

    2016-07-01

    Subcellular compartmentation of the ubiquitous second messenger cAMP has been widely proposed as a mechanism to explain unique receptor-dependent functional responses. How exactly compartmentation is achieved, however, has remained a mystery for more than 40 years. In this study, we developed computational and mathematical models to represent a subcellular sarcomeric space in a cardiac myocyte with varying detail. We then used these models to predict the contributions of various mechanisms that establish subcellular cAMP microdomains. We used the models to test the hypothesis that phosphodiesterases act as functional barriers to diffusion, creating discrete cAMP signaling domains. We also used the models to predict the effect of a range of experimentally measured diffusion rates on cAMP compartmentation. Finally, we modeled the anatomical structures in a cardiac myocyte diad, to predict the effects of anatomical diffusion barriers on cAMP compartmentation. When we incorporated experimentally informed model parameters to reconstruct an in silico subcellular sarcomeric space with spatially distinct cAMP production sites linked to caveloar domains, the models predict that under realistic conditions phosphodiesterases alone were insufficient to generate significant cAMP gradients. This prediction persisted even when combined with slow cAMP diffusion. When we additionally considered the effects of anatomic barriers to diffusion that are expected in the cardiac myocyte dyadic space, cAMP compartmentation did occur, but only when diffusion was slow. Our model simulations suggest that additional mechanisms likely contribute to cAMP gradients occurring in submicroscopic domains. The difference between the physiological and pathological effects resulting from the production of cAMP may be a function of appropriate compartmentation of cAMP signaling. Therefore, understanding the contribution of factors that are responsible for coordinating the spatial and temporal

  17. cAMP biosensors applied in molecular pharmacological studies of G protein-coupled receptors

    DEFF Research Database (Denmark)

    Mathiesen, Jesper Mosolff; Vedel, Line; Bräuner-Osborne, Hans

    2013-01-01

    end-point assays for quantifying GPCR-mediated changes in intracellular cAMP levels exist. More recently, fluorescence resonance energy transfer (FRET)-based cAMP biosensors that can quantify intracellular cAMP levels in real time have been developed. These FRET-based cAMP biosensors have been used...... primarily in single cell FRET microscopy to monitor and visualize changes in cAMP upon GPCR activation. Here, a similar cAMP biosensor with a more efficient mCerulean/mCitrine FRET pair is described for use in the 384-well plate format. After cloning and expression in HEK293 cells, the biosensor is...... characterized in the 384-well plate format and used for measuring the signaling of the G(s)-coupled ß(2)-adrenergic receptor. The procedures described may be applied for other FRET-based biosensors in terms of characterization and conversion to the 384-well plate format....

  18. WEBSITE AS A MARKETING TOOL IN TOURISM : Website Design for Svanen Camping Site

    OpenAIRE

    Paudel, Binaya

    2012-01-01

    The aim of this thesis was to a give little introduction into modern marketing tools in tourism, such as, websites, Facebook, YouTube, Twitter and Google Plus, and to modify the existing website of Svanen camping, Pietarsaari/ Jakobstad attractively. The Svanen camping is run during the summer by Central Ostrobothnia University of Applied Sciences (COU) since 2004. It is owned by the town of Pietarsaari. The camping is managed by Centria – Research and Development. Jennie Elfving, who is a re...

  19. The effectiveness of an American science camp for Taiwanese high school students

    Science.gov (United States)

    Kuo, Pi-Chu

    The purposes of this study were: (1) to evaluate the effectiveness of an American science camp for Taiwanese high school students in terms of student attitudes toward science; (2) to understand the factors that affect student attitudes toward science in the American science camp. Qualitative and quantitative data were collected and analyzed to answer my research questions: (1) How did the influence of the abroad science camp differ from the local one in terms of student attitudes toward science? (2) How did gender, grade level, and personality affect student attitudes toward science in the abroad science camp? An Attitudes toward Science Inventory was used in this study to measure student attitudes. The results of factor analysis suggested that the attitudes measured in this study include five common factors: science as school subjects (SC), science in society (SS), value of science (VS), science in laboratory (SL), and nature of science (NS). Significant improvements were found in SS, VS, and NS after the experiences of the abroad science camp. In the local science camp, only NS was non-significant comparing before and after the camp. The results from the comparisons between the two science camps show that different program designs have different impacts on student attitudes toward science. Furthermore, whether the science camps are designed based on learning theory or not, and regardless of how much time the campers spend in science-related activities during science camps, science camps can motivate students' interests in learning science. The results of mixed-design ANOVA for gender, grade level, and personality suggest that most of these personal factors did not significantly affect student attitudes. However, extraversion/introversion and sensing/intuition had impacts on the persuasibility of the abroad science camp.

  20. Modeling Soil Loss to Determine Water Erosion Risk at Camp Williams National Guard Base, Utah

    OpenAIRE

    Bartsch, Kevin P.

    1998-01-01

    Soil erosion was assessed at Camp Williams National Guard Base by creating an erosion risk classification map and comparing the erosion impact of disturbance regimes on different hillslopes. Soil erosion does not appear to be a problem for most of Camp Williams. The Revised Universal Soil Loss Equation was applied using GIS to create a soil erosion risk map for the entire Camp Williams facility. The map indicated where problem areas occurred and showed relative erosion risk, but its lack o...

  1. cAMP Level Modulates Scleral Collagen Remodeling, a Critical Step in the Development of Myopia

    OpenAIRE

    Tao, Yijin; Pan, Miaozhen; Liu, Shufeng; Fang, Fang; Lu, Runxia; Lu, Chanyi; Zheng, Min; An, Jianhong; Xu, Hongjia; Zhao, Fuxin; Chen, Jiang-Fan; Qu, Jia; Zhou, Xiangtian

    2013-01-01

    The development of myopia is associated with decreased ocular scleral collagen synthesis in humans and animal models. Collagen synthesis is, in part, under the influence of cyclic adenosine monophosphate (cAMP). We investigated the associations between cAMP, myopia development in guinea pigs, and collagen synthesis by human scleral fibroblasts (HSFs). Form-deprived myopia (FDM) was induced by unilateral masking of guinea pig eyes. Scleral cAMP levels increased selectively in the FDM eyes and ...

  2. Algae blooms and their consequences on camping tourism destinations: The case of Öland, Sweden

    OpenAIRE

    Foghagen, Christer

    2011-01-01

    In Sweden camping tourism holds the position as one of the largest niches within the tourism accommodation sector. The camping sector represents more than 17 million or 35% of commercial overnight stays in total. On the island of Öland which is located in Kalmar county, and in Kalmar county itself, the camping sector represents more than 1.75 million or 65% of the annual overnight stays which positions Kalmar and Öland as the second largest camping region in Sweden. However, tourism businesse...

  3. USE OF MODIFIED CAMP TEST FOR PRELIMINARY NONSEROLOGIC IDENTIFICATION OF VIBRIO CHOLERAE IN STOOL SPECIMENS

    Directory of Open Access Journals (Sweden)

    Murad Lesmana

    2012-09-01

    Full Text Available Suatu modifikasi uji CAMP digunakan bersama dengan reaksi biokimiawi untuk identifikasi Vibrio cholerae pada sampel klinis. Dari 579 usap dubur penderita diare, 92 (16% memberikan hasil isolasi V. cholerae 01 biotipe El Tor dan 34 (6% V. cholerae non-01. Semua isolat V. cholerae 01 El Tor menunjukkan reaksi CAMP positif kuat dengan gambaran hemolisis sinergistik lengkap berbentuk sosis; sedangkan V. cholerae non-01 memberikan reaksi CAMP yang sempit dengan pola hemolisis menyerupai bulan sabit. Hasil uji CAMP yang dilakukan bersama dengan reaksi biokimiawi sesuai dengan metode biakan konvensional yang menyertakan tes aglutinasi dengan antiserum V. cholerae 01 untuk mengidentifikasi V. cholerae.

  4. "cAMP sponge": a buffer for cyclic adenosine 3', 5'-monophosphate.

    Directory of Open Access Journals (Sweden)

    Konstantinos Lefkimmiatis

    Full Text Available BACKGROUND: While intracellular buffers are widely used to study calcium signaling, no such tool exists for the other major second messenger, cyclic AMP (cAMP. METHODS/PRINCIPAL FINDINGS: Here we describe a genetically encoded buffer for cAMP based on the high-affinity cAMP-binding carboxy-terminus of the regulatory subunit RIbeta of protein kinase A (PKA. Addition of targeting sequences permitted localization of this fragment to the extra-nuclear compartment, while tagging with mCherry allowed quantification of its expression at the single cell level. This construct (named "cAMP sponge" was shown to selectively bind cAMP in vitro. Its expression significantly suppressed agonist-induced cAMP signals and the downstream activation of PKA within the cytosol as measured by FRET-based sensors in single living cells. Point mutations in the cAMP-binding domains of the construct rendered the chimera unable to bind cAMP in vitro or in situ. Cyclic AMP sponge was fruitfully applied to examine feedback regulation of gap junction-mediated transfer of cAMP in epithelial cell couplets. CONCLUSIONS: This newest member of the cAMP toolbox has the potential to reveal unique biological functions of cAMP, including insight into the functional significance of compartmentalized signaling events.

  5. Classification of MEC with the ALLTEM at Camp Stanley, Texas

    Science.gov (United States)

    Asch, T.; Moulton, C.; Smith, D.V.

    2011-01-01

    The ALLTEM is a multi-axis electromagnetic induction system designed for unexploded ordnance UXO applications. It uses a continuous triangle-wave excitation and provides good late-time signal-to-noise ratio SNR especially for ferrous targets. Multi-axis transmitter Tx and receiver Rx systems such as ALLTEM provide a richer data set from which to invert for the target parameters required to distinguish between clutter and UXO. Inversions of field data acquired between 2006 and 2010 over the Army's UXO Standardized Test sites at the Yuma Proving Ground YPG in Arizona and at the Aberdeen Proving Ground APG in Maryland have produced reasonable and generally repeatable results for many UXO items buried at different orientations and depths. In February-March 2011 ALLTEM data was acquired at two locations on the Camp Stanley Storage Activity CSSA just north of San Antonio, Texas. Camp Stanley is used to store munitions as well as test, fire, and overhaul munitions components. Site B-20 is an open burn/open detonation OBOD area and Site B-27 consists of narrow trenches blasted into limestone containing buried range and munitions debris and possibly MEC. The processing, analysis, and classification techniques developed at the controlled environments of YPG and APG have been applied to these two "live" sites at Camp Stanley. ALLTEM data analysis includes both classical numerical inversion of data from each anomaly and clustering of the raw data by means of a self-organizing map SOM via generalized neural network algorithms. Final classification consists of an integration of both the numerical and SOM results. ?? 2011 Society of Exploration Geophysicists.

  6. Elevated cAMP increases aquaporin-3 plasma membrane diffusion

    DEFF Research Database (Denmark)

    Marlar, Saw; Christensen, Eva Arnspang; Koffman, Jennifer Skaarup;

    2014-01-01

    exits via basolateral AQP3 and AQP4. Upon long-term stimulation with AVP or during thirst, expression levels of both AQP2 and AQP3 are increased; however, there is so far no evidence for short-term AVP regulation of AQP3 or AQP4. To facilitate the increase in transepithelial water transport, AQP3 may be.......05)]. Immunoelectron microscopy showed no obvious difference in AQP3-EGFP expression levels or localization in the plasma membrane upon forskolin stimulation. Thus AQP3-EGFP diffusion is altered upon increased cAMP, which may correspond to basolateral adaptations in response to the increased apical water readsorption...

  7. Genetically-encoded tools for cAMP probing and modulation in living systems.

    Directory of Open Access Journals (Sweden)

    Valeriy M Paramonov

    2015-09-01

    Full Text Available Intracellular 3'-5'-cyclic adenosine monophosphate (cAMP is one of the principal second messengers downstream of a manifold of signal transduction pathways, including the ones triggered by G protein-coupled receptors. Not surprisingly, biochemical assays for cAMP have been instrumental for basic research and drug discovery for decades, providing insights into cellular physiology and guiding pharmaceutical industry. However, despite impressive track record, the majority of conventional biochemical tools for cAMP probing share the same fundamental shortcoming - all the measurements require sample disruption for cAMP liberation. This common bottleneck, together with inherently low spatial resolution of measurements (as cAMP is typically analyzed in lysates of thousands of cells, underpin the ensuing limitations of the conventional cAMP assays: 1 genuine kinetic measurements of cAMP levels over time in a single given sample are unfeasible; 2 inability to obtain precise information on cAMP spatial distribution and transfer at subcellular levels, let alone the attempts to pinpoint dynamic interactions of cAMP and its effectors. At the same time, tremendous progress in synthetic biology over the recent years culminated in drastic refinement of our toolbox, allowing us not only to bypass the limitations of conventional assays, but to put intracellular cAMP life-span under tight control – something, that seemed scarcely attainable before. In this review article we discuss the main classes of modern genetically-encoded tools tailored for cAMP probing and modulation in living systems. We examine the capabilities and weaknesses of these different tools in the context of their operational characteristics and applicability to various experimental set-ups involving living cells, providing the guidance for rational selection of the best tools for particular needs.

  8. Rapid Assessment of Seismic Vulnerability in Palestinian Refugee Camps

    Science.gov (United States)

    Al-Dabbeek, Jalal N.; El-Kelani, Radwan J.

    Studies of historical and recorded earthquakes in Palestine demonstrate that damaging earthquakes are occurring frequently along the Dead Sea Transform: Earthquake of 11 July 1927 (ML 6.2), Earthquake of 11 February 2004 (ML 5.2). In order to reduce seismic vulnerability of buildings, losses in lives, properties and infrastructures, an attempt was made to estimate the percentage of damage degrees and losses at selected refugee camps: Al Ama`ri, Balata and Dhaishe. Assessing the vulnerability classes of building structures was carried out according to the European Macro-Seismic Scale 1998 (EMS-98) and the Fedral Emergency Management Agency (FEMA). The rapid assessment results showed that very heavy structural and non structural damages will occur in the common buildings of the investigated Refugee Camps (many buildings will suffer from damages grades 4 and 5). Bad quality of buildings in terms of design and construction, lack of uniformity, absence of spaces between the building and the limited width of roads will definitely increase the seismic vulnerability under the influence of moderate-strong (M 6-7) earthquakes in the future.

  9. cAMP signaling in cortisol-producing adrenal adenoma.

    Science.gov (United States)

    Calebiro, Davide; Di Dalmazi, Guido; Bathon, Kerstin; Ronchi, Cristina L; Beuschlein, Felix

    2015-10-01

    The cAMP signaling pathway is one of the major players in the regulation of growth and hormonal secretion in adrenocortical cells. Although its role in the pathogenesis of adrenocortical hyperplasia associated with Cushing's syndrome has been clarified, a clear involvement of the cAMP signaling pathway and of one of its major downstream effectors, the protein kinase A (PKA), in sporadic adrenocortical adenomas remained elusive until recently. During the last year, a report by our group and three additional independent groups showed that somatic mutations of PRKACA, the gene coding for the catalytic subunit α of PKA, are a common genetic alteration in patients with Cushing's syndrome due to adrenal adenomas, occurring in 35-65% of the patients. In vitro studies revealed that those mutations are able to disrupt the association between catalytic and regulatory subunits of PKA, leading to a cAMP-independent activity of the enzyme. Despite somatic PRKACA mutations being a common finding in patients with clinically manifest Cushing's syndrome, the pathogenesis of adrenocortical adenomas associated with subclinical hypercortisolism seems to rely on a different molecular background. In this review, the role of cAMP/PKA signaling in the regulation of adrenocortical cell function and its alterations in cortisol-producing adrenocortical adenomas will be summarized, with particular focus on recent developments. PMID:26139209

  10. Photovoltaic Technology of Electricity Generation for Desert Camping

    Directory of Open Access Journals (Sweden)

    Shafiqur Rehman

    2005-01-01

    Full Text Available This study presents a case study on the utilization of global solar radiation data on horizontal surface to perform economical feasibility of using Photovoltaic (PV panels with battery backup to meet a small load for a camping site in Saudi Arabia. The analysis considers three scenarios with daily average energy demands of: (i full load, (ii 75% load and (iii half load with annual peak load of 3.84, 3.06 and 2.27 kW, respectively. Each of these loads is further studied economically to investigate the effect of battery storage for 1 to 5 days. The study also compares the cost of electricity generation in $/kWh from PV system and diesel generating systems. The lower mean temperature (~20°C and high intensity of radiation (~ 6.3 kWh m2/day in Abha make it a promising site for the usage of PV systems for desert camping. Analysis of the data indicates that the battery storage capacity cost plays an important role in the overall cost of the PV system. The economical indicators suggest that larger PV systems be preferred over the smaller ones with minimal storage option. The energy generation cost analysis indicated that the diesel generating cost was found to be 29, 56 and 116% higher than the PV system for full, 75% and half load systems, respectively.

  11. A Temporal-Specific and Transient cAMP Increase Characterizes Odorant Classical Conditioning

    Science.gov (United States)

    Cui, Wen; Smith, Andrew; Darby-King, Andrea; Harley, Carolyn W.; McLean, John H.

    2007-01-01

    Increases in cyclic adenosine monophosphate (cAMP) are proposed to initiate learning in a wide variety of species. Here, we measure changes in cAMP in the olfactory bulb prior to, during, and following a classically conditioned odor preference trial in rat pups. Measurements were taken up to the point of maximal CREB phosphorylation in olfactory…

  12. Interpreting Camp to Parents: A Better Way to Observe--Record--Report. An Occasional Paper.

    Science.gov (United States)

    Shopper, Moisy

    1980-01-01

    Camps offer a unique opportunity to inform parents of the psychological workings of their child through information based on a large repertoire of situations. Camps can be interpreted to parents as a better way to observe, record, and report how their children: (1) reacted to "on-hand contact"; (2) accepted duties and responsibility; (3) improved…

  13. Assessment of the Psychosocial Development of Children Attending Nursery Schools in Karen Refugee Camps in Thailand

    Science.gov (United States)

    Tanaka, Akiko

    2013-01-01

    The Karen, an ethnic minority group in Burma, have experienced a prolonged state of exile in refugee camps in neighboring Thailand because of ethnic conflict in their home country. Nursery schools in the three largest Karen refugee camps aim to promote the psychosocial development of young children by providing a child-centered, creative,…

  14. Which Social Emotional Competencies Are Enhanced at a Social Emotional Learning Camp?

    Science.gov (United States)

    Ee, Jessie; Ong, Chew Wei

    2014-01-01

    Research studies have shown that educational programmes such as camps and field trips can develop affective and social relationships through personal exposure to outdoor experiences among students. This study will illustrate the outcome of a social emotional learning camp organized for 93 Secondary Two students (mean age 14.1) in Singapore. Both…

  15. The Efficacy of Mammography Boot Camp to Improve the Performance of Radiologists

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eun Hye [Dept. of Radiology, Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon (Korea, Republic of); Jun, Jae Kwan [National Cancer Control Institute, National Cancer Center, Goyang (Korea, Republic of); Jung, Seung Eun [Dept. of Radiology, Seoul St. Mary' s Hospital, College of Medicine, The Catholic University of Korea, Seoul (Korea, Republic of); Kim, You Me [Dept. of Radiology, Dankook University Hospital, Cheonan (Korea, Republic of); Choi, Nami [Dept. of Radiology, Konkuk University Medical Center, Seoul (Korea, Republic of)

    2014-10-15

    To evaluate the efficacy of a mammography boot camp (MBC) to improve radiologists' performance in interpreting mammograms in the National Cancer Screening Program (NCSP) in Korea. Between January and July of 2013, 141 radiologists were invited to a 3-day educational program composed of lectures and group practice readings using 250 digital mammography cases. The radiologists' performance in interpreting mammograms were evaluated using a pre- and post-camp test set of 25 cases validated prior to the camp by experienced breast radiologists. Factors affecting the radiologists' performance, including age, type of attending institution, and type of test set cases, were analyzed. The average scores of the pre- and post-camp tests were 56.0 ± 12.2 and 78.3 ± 9.2, respectively (p < 0.001). The post-camp test scores were higher than the pre-camp test scores for all age groups and all types of attending institutions (p < 0.001). The rate of incorrect answers in the post-camp test decreased compared to the pre-camp test for all suspicious cases, but not for negative cases (p > 0.05). The MBC improves radiologists' performance in interpreting mammograms irrespective of age and type of attending institution. Improved interpretation is observed for suspicious cases, but not for negative cases.

  16. 78 FR 55671 - Hospital Care and Medical Services for Camp Lejeune Veterans

    Science.gov (United States)

    2013-09-11

    ... hospital care and medical services. As discussed in a separate notice (78 FR 39832, July 2, 2013), we are... their service at Camp Lejeune. Section 102 of Public Law 112-154 requires VA to provide hospital care... AFFAIRS 38 CFR Part 17 RIN 2900-AO78 Hospital Care and Medical Services for Camp Lejeune Veterans...

  17. Camp Thunderbird: Taking Flight with Dance and Physical Education for Special Populations

    Science.gov (United States)

    Keglon, Johnnye

    2011-01-01

    This article describes the Dallas-based Camp Thunderbird, an enrichment program that brought together minority students in special education and students from general education for a summer of physical activity and the arts. Among the camp participants were students who functioned at a high level in the areas of autism spectrum disorders, mental…

  18. Strategies for Developing a University-Sponsored Youth Sports Summer Camp

    Science.gov (United States)

    Walsh, David

    2011-01-01

    During the summer, universities have the ability to offer on-campus camps that serve the health, physical activity, and educational needs of youths. However, the tasks, responsibilities, time, and knowledge needed to run a camp can be overwhelming. This article describes the administrative components of the lessons learned from the development of…

  19. The modulation of cell surface cAMP receptors from Dictyostelium disscoideum by ammonium sulfate

    NARCIS (Netherlands)

    Haastert, Peter J.M. van

    1985-01-01

    Dictyostelium discoideum cells contain a heterogeneous population of cell surface cAMP receptors with components possessing different affinities (Kd between 15 and 450 nM) and different off-rates of the cAMP-receptor complex (t½ between 0.7 and 150 s). The association of cAMP to the receptor and the

  20. Camper learning and friendship at pediatric oncology camps in North America.

    Science.gov (United States)

    Martiniuk, Alexandra L C; Amylon, Michael D; Briery, Brandon G; Shea-Perry, Marci; Kelsey, Kathleen P; Lam, Gary W; Körver, Sarah

    2014-01-01

    Children with cancer and their families often attend specialized camps (therapeutic recreation) through their cancer treatment journey, yet little is known about the effects of these camps. A qualitative cohort study was used to assess learning and friendship development by campers attending one of four pediatric oncology summer camps during 2010 in North America. Standardized perceived change questionnaires developed by the American Camp Association were administered following camp attendance. Five-hundred and eighteen campers were enrolled: 120 (age 6-9 years) and 398 (age 10 and older). The largest positive response from the younger campers was observed for the question, "At camp did you learn to look forward to trying new activities?" For the older campers' survey, the items "Becoming better at enjoying being with my friends," "Becoming better at helping my friends have a good time when they are with me," and "Becoming better at getting to know more things about my friends" were perceived to increase the most for the majority of campers compared to other questions. Items for which older campers most often perceived little change were "Becoming better at choosing people who would be good friends to be with" and "Becoming better at understanding friends' emotions." Camp helps children learn new activities as well as enjoy good times with friends. Dealing with one's own mistakes and understanding others' emotions are areas for improvement. Ultimately it is hoped that these skills gained at camp will help build coping and resiliency for children/siblings affected by pediatric cancers. PMID:24364990

  1. Alexander Pechersky Testifies: an Open Page of Sobibor Death Camp History

    Directory of Open Access Journals (Sweden)

    Lev S. Simkin

    2013-01-01

    Full Text Available Here, the author introduces the interrogation of the witness Alexander Aronovich Pechersky, the leader of the German death camp Sobibor Revolt during the World War II. Special attention is attached to the daily life of the death camp. The picture of revolt preparation was completed

  2. Science Camps in Europe--Collaboration with Companies and School, Implications and Results on Scientific Literacy

    Science.gov (United States)

    Lindner, M.; Kubat, C.

    2014-01-01

    The paper informs on the characteristics of a Comenius Network of seven organizations, who are collaborating in exchanging best practice on science camps. This exchange includes evaluation results on more science camps of European organizations, which will deliver information on organization, collaboration with companies, pedagogical aspects, as…

  3. Offering a Forensic Science Camp to Introduce and Engage High School Students in Interdisciplinary Science Topics

    Science.gov (United States)

    Ahrenkiel, Linda; Worm-Leonhard, Martin

    2014-01-01

    In this article, we present details of a one-week interdisciplinary science camp for high school students in Denmark, "Criminal Camp". We describe the use of forensic science and simulated crimes as a common foundation for teaching the theory and practice of concepts in chemistry, physics, and medicine or biology. The main goal of the…

  4. Dimensions of Flow in Academic and Social Activities among Summer Music Camp participants

    Science.gov (United States)

    Diaz, Frank M.; Silveira, Jason M.

    2013-01-01

    The purpose of this study was to investigate the occurrence of flow experiences among high school music students attending a two-week summer instrumental music camp. Specifically, the study sought to determine if: (1) students do indeed experience flow in summer camp settings; (2) what activities are conducive to flow; (3) what is the relationship…

  5. Student-Designed Mapping Project as Part of a Geology Field Camp

    Science.gov (United States)

    Kelley, Daniel F.; Sumrall, Jeanne L.; Sumrall, Jonathan B.

    2015-01-01

    During the summer of 2012, the Louisiana State University (LSU) field camp program was affected by close proximity to the large Waldo Canyon Fire in Colorado Springs, CO, as well as by a fire incident on the field camp property. A mapping exercise was created that incorporated spatial data acquired on the LSU property to investigate research…

  6. Camp Read-a-Rama® and Fully-Engaged Literacy Learning: Implications for LIS Education

    Science.gov (United States)

    Copeland, Clayton A.; Martin, Michelle H.

    2016-01-01

    Literacy and literacy skill development remain critical concerns in the U.S. "Two of every three students in the U.S. do not have the necessary reading proficiencies to successfully complete grade-level work" (Allington, 2011). Camp Read-a-Rama, a summer day camp in South Carolina for 4- to 11-year-olds, creates innovative programming…

  7. A summer blender camp: modeling, rendering, and animation for high school students.

    Science.gov (United States)

    Bailey, Mike; Law, Cathy

    2014-01-01

    At Camp Blender, high-school students of varying backgrounds learned how to use the Blender software package to create computer graphics content. In a postclass survey, most of them indicated that the camp affected how they thought about their career path. PMID:24808169

  8. The progressive nature of concentration camp syndrome in former prisoners of Nazi concentration camps--Not just history, but the important issue of contemporary medicine.

    Science.gov (United States)

    Jabłoński, Robert; Rosińczuk, Joanna; Leszek, Jerzy; Uchmanowicz, Izabella; Panaszek, Bernard

    2016-04-01

    Constant stress, slave labor, tortures, and starvation all affected the health of concentration camp prisoners, contributing to multimorbidities, increased mortality and accelerated development of chronic illnesses, what we have shown in an earlier publication. The interrelated somatic and psychological symptoms gave rise to concentration camp syndrome (KZ-syndrome), which has many features of PTSD, occurring frequently nowadays. The paper attempts at assessing the influence of concentration camp conditions on functional disorders in each system of the human body, occurring in KZ-syndrome, and at demonstrating the progressive nature of the syndrome. A retrospective assessment of the former prisoners' health after 5 and 30 years following their leaving camps was performed based on medical records and surveys. The materials included 250 former prisoners who underwent medical examination in 1950, i.e. 5 years after leaving the camp, of whom 120 former prisoners survived and were examined and surveyed in 1975, i.e. 30 years after leaving the camp. KZ-syndrome was shown to occur in 58.8% of former prisoners 5 years after leaving the camp, and in 77.5% after 30 years (p < 0.001), which confirms the syndrome's chronic and progressive nature. Pathological sequels of internment in concentration camps, in the form of KZ-syndrome, were observed in most former prisoners. Over time, the number of morbidities and the intensity of symptoms increased, which indicates that the syndrome has a chronic and progressive nature. KZ-syndrome is a multi-organ disorder, with numerous chronic comorbidities exacerbating the progression. PMID:26783727

  9. Evaluation of undergraduate nursing students' clinical confidence following a mental health recovery camp.

    Science.gov (United States)

    Cowley, Thomas; Sumskis, Sue; Moxham, Lorna; Taylor, Ellie; Brighton, Renee; Patterson, Chris; Halcomb, Elizabeth

    2016-02-01

    In the present study, we evaluate the impact of participation in a mental health recovery camp on the clinical confidence of undergraduate nursing students in dealing with individuals with mental illness. Twenty undergraduate nursing students who participated in the recovery camp completed the Mental Health Nursing Clinical Confidence Scale both before and directly after attending the camp. Data were analysed using descriptive and inferential statistics. Participation in the recovery camp was associated with a statistically-significant increase in students' level of overall confidence between the pretest and post-test data (P level of confidence in both the pre- and post-results. The clinical confidence of undergraduate nursing students improved through participation in an immersive clinical experience within the recovery camp. PMID:26767715

  10. Free will in total institutions: The case of choice inside Nazi death camps.

    Science.gov (United States)

    Davidov, Jonathan; Eisikovits, Zvi

    2015-07-01

    Nazi death camps, as any total institutions, were designed to deny any free will or choice from inmates. Furthermore, former inmates in such extreme conditions often account for their own actions and behavior in such settings as inevitable ("I had no other choice"). This study examines the questions of free will vs. determinism in death camps from a descriptive-phenomenological perspective. Data was collected through in-depth interviews with 20 former death camp inmates. The following themes emerged from the qualitative analysis of the data: the 'selection' experience; 'borrowed time' perception; and the experience of 'nothingness'. A conceptual model grounded in these data was developed to illustrate the inmate's lived experience of choice in the reality of the camps. Analysis of the model indicates that under the extreme conditions of the death camp, free will and existence are interchangeable: "I choose - therefore I am". PMID:25881235

  11. Resting easier : large or small, Canada's flock of remote camp operators senses better times ahead

    Energy Technology Data Exchange (ETDEWEB)

    Flackstad, N.

    2010-09-15

    This article described recent trends in the provision of remote mobile housing in the oil patch. Contemporary camps are used as recruiting tools to help attract workers, and they feature modern conveniences. Many mobile camps stay in place for years, moving only when a major project is completed or the resource depleted. Smaller camp configurations tend to be moved more frequently. Mobile camps can move from a resource site without leaving any imprint. The business models of various companies involved in remote camp operations were described, along with both large and small projects. Some companies supply inclusive packages covering accommodation, catering, water/sanitation services, camp management, and related logistics, whereas others focus on a single aspect. The slowdown in drilling had depressed remote-camp utilization, but the increase in activity is spurring the demand for remote-camp operators, and the outlook for utilization rates is optimistic. There is an increasing movement towards an open camp housing model. Whereas past work camps would serve one project or one company, open camps are more like remote, temporary hotels. Open camps are suitable when travel distances to permanent accommodations are lengthy and the long-term economics make setting up permanent hotels close to field operations unfeasible. 4 figs.

  12. Crisis DSM Generation To Support Refugee Camp Management

    Science.gov (United States)

    Gstaiger, Veronika; d'Angelo, Pablo; Schneiderhan, Tobais; Krauss, Thomas

    2013-12-01

    The extraction of high resolution surface information from satellite data has become an important area of research. One of the numerous fields of application is disaster management. Detailed information about the affected terrain is not only needed for analyses during the emergency relief phase, but also for reconstruction and prevention activities. In this paper the authors present the generation of a Digital Surface Model (DSM) based on three very high resolution optical satellite images. The DSM was produced to supplement a flood mapping activity in Jordan and serves as example for the implementation of scientific results during an emergency request. The flood affected the Zaatari refugee camp in Jordan and was mapped by the Center for Satellite Based Crisis Information (ZKI) at the German Aerospace Center (DLR) in January 2013 under emergency mapping conditions.

  13. Agitation and Propagandistic Work in Soviet POW Camps

    Directory of Open Access Journals (Sweden)

    Gulzhaukhar K. Kokebayeva

    2014-06-01

    Full Text Available The paper studies the problem of agitation work done among POWs in Soviet camps, the creation of military units and political organizations from POWs. Not only armed force was used during the Second World War, but also the power of words. The battles were accompanied by the information warfare. Opponents tried to use all possible means to manipulate people’s minds. Main directions of agitation and propaganda were defined by the «Soviet bureau of military and political propaganda», as well as the 7th Division of Soviet army. In the propaganda work among German POWs, the priority was given on shaping the ideological and political views of former soldiers and officers of the Wehrmacht. As the result of the analysis of sources the author comes to conclusion that POWs of the Second World War period became the object of testing means and methods of ideological struggle of warring nations.

  14. Laser camp: shining a light on optics careers

    Science.gov (United States)

    Donnelly, Judith; Goyette, Donna; Magnani, Nancy; Wosczyna-Birch, Karen

    2008-08-01

    Three Rivers Community College offers two associate degree programs in optics/photonics, and graduates have their choice of jobs in New England and across the United States. Nonetheless, students, their parents, teachers and guidance counselors are largely unaware of the career opportunities in the photonics industry. To promote optics/photonics career awareness, we hosted two versions of "Laser Camp" in 2007 and 2008. Hands-on activities were chosen to promote awareness of optical science and technology careers and to provide "take home" information and souvenirs to share with family and friends. In this paper, we discuss the logistics of funding, marketing, permissions, transportation and food service and share our student-tested activities.

  15. UAV Survey Data from Clifton Camp (ST56557330, Bristol, UK

    Directory of Open Access Journals (Sweden)

    Stephen Gray

    2015-05-01

    Full Text Available This data was collected via low-altitude UAV (Unmanned Aerial Vehicle survey of an area of Clifton Camp (ST565557330, best known for its Iron Age promontory fort. The dataset comprises of metadata records, near-vertical photographs and a derived 3D polygonal mesh. This dataset has been constructed with two kinds of reuse in mind: Firstly, the area surveyed is culturally rich and underexplored; while some of the non-natural features detected by this survey can be identified, others cannot. This data is intended to inform future investigations of the site. Secondly, the survey methodologies employed and the structuring of the resulting dataset are intended to act as an exemplar, a standard method of creating survey data while prioritising open technologies, and of organising UAV survey datasets to ensure maximum re-usability.

  16. Suicide in Inmates in Nazis and Soviet Concentration Camps: Historical Overview and Critique

    Science.gov (United States)

    López-Muñoz, Francisco; Cuerda-Galindo, Esther

    2016-01-01

    Living conditions in concentration camps were harsh and often inhumane, leading many prisoners to commit suicide. We have reviewed this topic in Nazi concentration camps (KL), Soviet special camps, and gulags, providing some preliminary data for our research. Data show that the incidence of suicide in Nazi KL could be up to 30 times higher than the general population and was also much higher than in Soviet special camps (maybe due to more favorable conditions for prisoners and the abolishment of death penalty), while available data on Soviet gulags are contradictory. However, data interpretation is very controversial, because, for example, the Nazi KL authorities used to cover-up the murder victims as suicides. Most of the suicides were committed in the first years of imprisonment, and the method of suicide most commonly used was hanging, although other methods included cutting blood vessels, poisoning, contact with electrified wire, or starvation. It is possible to differentiate two behaviors when committing suicide; impulsive behavior (contact with electrified barbed wire fences) or premeditated suicide (hanging up or through poison). In Soviet special camps, possible motives for suicides could include feelings of guilt for crimes committed, fear of punishment, and a misguided understanding of honor on the eve of criminal trials. Self-destructive behaviors, such as self-mutilation in gulag camps or prisoners who let themselves die, have been widely reported. Committing suicide in concentration camps was a common practice, although precise data may be impossible to obtain. PMID:27303312

  17. The effect of radioprotectors and ionizing radiation on the cAMP system

    International Nuclear Information System (INIS)

    A number of changes characteristic of all the radioprotectors which appear to play a key role in the radioprotective effect can be distinguished from a variety of radioprotector-caused processes in cells and tissues known to date. Experiments have revealed an increase in cAMP concentration in cells and tissues under the effect of radioprotectors belonging to different classes of chemical compounds. Biogenic amines account for the following reaction sequence: adenylate cyclase activation followed by an increase in cAMP concentration. The augmentation of cAMP level resultant from the effect of sulfur-containing protectors takes an indirect route since adenylate cyclase activation or phosphodiesterase inhibition have not been recorded. It is suggested that an increase in cAMP concentration brought about by sulfur-containing protectors is mediated by biogenic amines as these protectors activate biogenic amine synthesis to increase the level of biogenic amines in tissues, biogenic amines in these concentrations activating adenylate cyclase. The evidence on the dynamics of cAMP level changes after administration of radioprotectors are consistent with the above suggestion. Investigations of the effect of ionizing radiations on the intracellular regulator (cAMP) system account for some of the manifestations of radiation disease. Some data on the effect of radiations on the cAMP system enzymes are given. Changes in the enzyme activity are noted. Possible mechanisms and consequences of these changes are discussed

  18. Suicide in Inmates in Nazis and Soviet Concentration Camps: Historical Overview and Critique.

    Science.gov (United States)

    López-Muñoz, Francisco; Cuerda-Galindo, Esther

    2016-01-01

    Living conditions in concentration camps were harsh and often inhumane, leading many prisoners to commit suicide. We have reviewed this topic in Nazi concentration camps (KL), Soviet special camps, and gulags, providing some preliminary data for our research. Data show that the incidence of suicide in Nazi KL could be up to 30 times higher than the general population and was also much higher than in Soviet special camps (maybe due to more favorable conditions for prisoners and the abolishment of death penalty), while available data on Soviet gulags are contradictory. However, data interpretation is very controversial, because, for example, the Nazi KL authorities used to cover-up the murder victims as suicides. Most of the suicides were committed in the first years of imprisonment, and the method of suicide most commonly used was hanging, although other methods included cutting blood vessels, poisoning, contact with electrified wire, or starvation. It is possible to differentiate two behaviors when committing suicide; impulsive behavior (contact with electrified barbed wire fences) or premeditated suicide (hanging up or through poison). In Soviet special camps, possible motives for suicides could include feelings of guilt for crimes committed, fear of punishment, and a misguided understanding of honor on the eve of criminal trials. Self-destructive behaviors, such as self-mutilation in gulag camps or prisoners who let themselves die, have been widely reported. Committing suicide in concentration camps was a common practice, although precise data may be impossible to obtain. PMID:27303312

  19. Distancing Students From Nature: Science Camp and the Representation of the Human-Nature Relationship

    Science.gov (United States)

    Terrill, Laura Anne

    This study investigated the curricular representations of the environment and the human-environment relationship at one residential school sponsored science camp. Data gathered included field notes from observational time at the camp, interviews with staff and classroom teachers, and documents from the site's website, guides, manuals, and curricular guides. These data were analyzed to understand how the camp represented the human-environment relationship and the "proper" human-environment relationship to its participants. Analysis indicated that the camp's official and enacted curriculum was shaped in response to two perceived problems, (1) students were perceived as having a disconnected relationship with the outdoors and lacking in outdoor experiences; and (2) staff members of the camp believed that time for science during the school day had diminished and that students were not receiving adequate science instruction at school. In response, the goal of the camp was to connect students to the outdoors through hands-on, sensory, experience based science and outdoor education experiences. However, key aspects of the camp experience and the formal and enacted curriculum unintentionally positioned students as separate from nature. The camp experience presented a vacation like understanding of the human-environment relationship as students became tourists of the outdoors. Despite the site's goal of connecting students to the outdoors, the science camp experience worked to distance students from the outdoors by unintentionally representing the outdoors as a place that existed away from home and students' everyday lives. Notably, nature became a place that existed in the past, separate from modernity. Students were tourists in an exotic location - nature. They received tours of the foreign outdoors, had fun, and returned home to their ordinary lives that were separate and distinct from the natural world.

  20. The accidental city : violence, economy and humanitarianism in Kakuma refugee camp Kenya

    OpenAIRE

    Jansen, B.J.

    2011-01-01

    In this research I examine social ordering processes in Kakuma refugee camp in Kenya. I view the camp as an accidental city, by which I challenge the image of the camp as a temporary and artificial waiting space or a protracted refugee crisis per se. The reference to the city is both metaphorically and physically relevant. First, the metaphorical dimension of the city places refugees and their negotiation of space into the realm of the normal and the possible, contrary to prevailing notions o...

  1. cAMP prevents TNF-induced apoptosis through inhibiting DISC complex formation in rat hepatocytes

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharjee, Rajesh [Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 (United States); Xiang, Wenpei [Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 (United States); Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People' s Republic of China (China); Wang, Yinna [Vascular Medicine Institute, University of Pittsburgh School of Medicine, 10051-5A BST 3, 3501 Fifth Avenue, Pittsburgh, PA 15261 (United States); Zhang, Xiaoying [Department of Medicine/Endocrinology Division, University of Pittsburgh Medical Center, 200 Lothrop St., Pittsburgh, PA 15213 (United States); Billiar, Timothy R., E-mail: billiartr@upmc.edu [Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 (United States)

    2012-06-22

    Highlights: Black-Right-Pointing-Pointer cAMP blocks cell death induced by TNF and actinomycin D in cultured hepatocytes. Black-Right-Pointing-Pointer cAMP blocks NF-{kappa}B activation induced by TNF and actinomycin D. Black-Right-Pointing-Pointer cAMP blocks DISC formation following TNF and actinomycin D exposure. Black-Right-Pointing-Pointer cAMP blocks TNF signaling at a proximal step. -- Abstract: Tumor necrosis factor {alpha} (TNF) is a pleiotropic proinflammatory cytokine that plays a role in immunity and the control of cell proliferation, cell differentiation, and apoptosis. The pleiotropic nature of TNF is due to the formation of different signaling complexes upon the binding of TNF to its receptor, TNF receptor type 1 (TNFR1). TNF induces apoptosis in various mammalian cells when the cells are co-treated with a transcription inhibitor like actinomycin D (ActD). When TNFR1 is activated, it recruits an adaptor protein, TNF receptor-associated protein with death domain (TRADD), through its cytoplasmic death effector domain (DED). TRADD, in turn, recruits other signaling proteins, including TNF receptor-associated protein 2 (TRAF2) and receptor-associated protein kinase (RIPK) 1, to form a complex. Subsequently, this complex combines with FADD and procaspase-8, converts into a death-inducing signaling complex (DISC) to induce apoptosis. Cyclic AMP (cAMP) is a second messenger that regulates various cellular processes such as cell proliferation, gene expression, and apoptosis. cAMP analogues are reported to act as anti-apoptotic agents in various cell types, including hepatocytes. We found that a cAMP analogue, dibutyryl cAMP (db-cAMP), inhibits TNF + ActD-induced apoptosis in rat hepatocytes. The protein kinase A (PKA) inhibitor KT-5720 reverses this inhibitory effect of cAMP on apoptosis. Cytoprotection by cAMP involves down-regulation of various apoptotic signal regulators like TRADD and FADD and inhibition of caspase-8 and caspase-3 cleavage. We also found

  2. Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.

    Science.gov (United States)

    Krishnamurthy, Srinath; Moorthy, Balakrishnan Shenbaga; Xin Xiang, Lim; Xin Shan, Lim; Bharatham, Kavitha; Tulsian, Nikhil Kumar; Mihalek, Ivana; Anand, Ganesh S

    2014-09-16

    Cyclic 3'5' adenosine monophosphate (cAMP)-dependent-protein kinase (PKA) signaling is a fundamental regulatory pathway for mediating cellular responses to hormonal stimuli. The pathway is activated by high-affinity association of cAMP with the regulatory subunit of PKA and signal termination is achieved upon cAMP dissociation from PKA. Although steps in the activation phase are well understood, little is known on how signal termination/resetting occurs. Due to the high affinity of cAMP to PKA (KD ∼ low nM), bound cAMP does not readily dissociate from PKA, thus begging the question of how tightly bound cAMP is released from PKA to reset its signaling state to respond to subsequent stimuli. It has been recently shown that phosphodiesterases (PDEs) can catalyze dissociation of bound cAMP and thereby play an active role in cAMP signal desensitization/termination. This is achieved through direct interactions with the regulatory subunit of PKA, thereby facilitating cAMP dissociation and hydrolysis. In this study, we have mapped direct interactions between a specific cyclic nucleotide phosphodiesterase (PDE8A) and a PKA regulatory subunit (RIα isoform) in mammalian cAMP signaling, by a combination of amide hydrogen/deuterium exchange mass spectrometry, peptide array, and computational docking. The interaction interface of the PDE8A:RIα complex, probed by peptide array and hydrogen/deuterium exchange mass spectrometry, brings together regions spanning the phosphodiesterase active site and cAMP-binding sites of RIα. Computational docking combined with amide hydrogen/deuterium exchange mass spectrometry provided a model for parallel dissociation of bound cAMP from the two tandem cAMP-binding domains of RIα. Active site coupling suggests a role for substrate channeling in the PDE-dependent dissociation and hydrolysis of cAMP bound to PKA. This is the first instance, to our knowledge, of PDEs directly interacting with a cAMP-receptor protein in a mammalian system, and

  3. 1992 Environmental Summer Science Camp Program evaluation. The International Environmental Institute of Westinghouse Hanford Company

    Energy Technology Data Exchange (ETDEWEB)

    1993-07-01

    This report describes the 1992 Westinghouse Hanford Company/US Department of Energy Environmental Summer Science Camp. The objective of the ``camp`` was to motivate sixth and seventh graders to pursue studies in math, science, and the environment. This objective was accomplished through hands-on fun activities while studying the present and future challenges facing our environment. The camp was funded through Technical Task Plan, 424203, from the US Department of Energy-Headquarters, Office of Environmental Restoration and Waste Management, Technology Development,to Westinghouse Hanford Company`s International Environmental Institute, Education and Internship Performance Group.

  4. Family camping: a case study of the potential for personal development

    Directory of Open Access Journals (Sweden)

    Ivo Jirásek

    2014-04-01

    Full Text Available The purpose of this study is to examine the family camping phenomenon and its educative potential in education between generations. The study focused on the tradition of family camping in the Czech countryside and it shows the club Veteran Green as a typical Czech example of this leisure activity. This study used a sequential combine design of empirical research based on an autoethnographic examination and survey of both adult (n = 14 and children (n = 14 participants (together from 9 families of a family camp in the Czech Republic. The paper indicated four dimensions of the leisure experience: the phenomena of family, community, nature and spirituality.

  5. Exogenous Camp upregulates the expression of glnII and glnK-amtB genes in Sinorhizobium meliloti 1021

    Institute of Scientific and Technical Information of China (English)

    TIAN Zhexian; MAO Xianjun; SU Wei; LI Jian; BECKER Anke; WANG Yiping

    2006-01-01

    The existence of multiple adenylate cyclase encoding genes implies the importance of Camp in Sinorhizobium meliloti 1021. In this study, as a pioneer step of understanding Camp roles, microarray analysis on S. Meliloti was carried out for the function of exogenous Camp. To our surprise, the result showed that the transcriptions of glnII and glnK genes were significantly upshifted in the presence of exogenous Camp in S. Meliloti. This phenomenon is further confirmed in S. Meliloti that the expression of either glnII or glnK promoter-lacZ translational fusion is higher in the presence of exogenous Camp.Therefore, for the first time, we have identified genes from S. Meliloti whose expression is activated by Camp. The potential physiological role of upregulation of glnII and glnK by Camp is discussed.

  6. Cultural behaviour and the invention of traditions: music and musical practices in the early concentration camps, 1933-6/7.

    Science.gov (United States)

    Fackler, Guido

    2010-01-01

    This article investigates music in the concentration camps before the second world war. For the camp authorities, ordering prisoners to sing songs or play in orchestras was an instrument of domination. But for the prisoners, music could also be an expression of solidarity and survival: inmates could retain a degree of their own agency in the pre-war camps, despite the often unbearable living conditions and harsh treatment by guards. The present article emphasizes this ambiguity of music in the early camps. It illustrates the emergence of musical traditions in the pre-war camps which came to have a significant impact on everyday life in the camps. It helps to overcome the view that concentration camp prisoners were simply passive victims. PMID:20845575

  7. From Death To Death:Some Thoughts about Indian Camp by Ernest Hemingway

    Institute of Scientific and Technical Information of China (English)

    LI Hui

    2014-01-01

    Based on Indian Camp, the thesis probes into the death complex of Ernest Hemingway from the visual angle of Nick, the protagonist of the novel, death complex shown in Hemingway’s works and Nick, the archetype of Hemingway respectively.

  8. How to Create a Day Camp Using the Resources of Your Community.

    Science.gov (United States)

    Hazelwood, James; Hazelwood, Lisa

    1986-01-01

    Outlines process of putting together a local week-long day camp: assessing community resources, developing a curriculum, choosing the staff (coordinator; teachers/counselors; assistants; directors of art, recreation, and music) and marketing the program. (NEC)

  9. Effects of a Structured Camp Experience on Locus of Control Orientation

    Science.gov (United States)

    Nowicki, Stephen, Jr.; Barnes, Jarvis

    1973-01-01

    Inner-city teenagers experienced a structured camp program for a week. It was predicted and found that this experience led to a change toward internality, in the locus of control orientation of these youngsters. (Authors)

  10. From charity and philanthropy to State social protection: school holiday camps in Spain (1887-1936

    Directory of Open Access Journals (Sweden)

    Pedro L. MORENO MARTÍNEZ

    2013-11-01

    Full Text Available School holiday camps, which started in Switzerland in 1886, would start to function in Spain under the institutionalist and director of the then called Museo de Instrucción Primaria de Madrid (Museum of Primary Instruction, Manuel B. Cossío, in 1887. The paper analyses briefly the social, hygienic and educational context in which international movement of summer camps made their appearance and with special reference to Spain. The paper focuses on the beginnings and the scope of these camps in Spain and on the influence of public policies on these processes. These policies shifted from initial government inhibition and the call to the forces of the country to charity and patriotism, to a progressive promotion and to State protection for the summer camps.

  11. Caxingo - a promising model for integrating the hydroelectric work camps to the site communities

    International Nuclear Information System (INIS)

    The social and economical impacts caused by the hydroelectric work camps in the sites where the hydroelectric will be constructed are studied, analysing the great supply of works when the hydroelectric is been constructed face to the reduction one when the works are concluded; the neglect by the State in providing medical and educational assistances to the neighbour populations; the appearance of a commerce in the neighbour areas; the employer stableness in the camp after the pension and the lack by the neighbour cities of a social and economical substructure to offer to the population, that come with the hydroelectric construction. A new solution for these problems is presented in the Xingo camp, where the camp will be as a district of city near to the work, with community services provide by the State and the needful substructure to its construction and the equipment provide by the concessionaire. (C.G.C.). 1 fig

  12. Fiscal year 1939 : Narrative report : Pea Island Migratory Wildfowl Refuge : Camp BF-2

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This 1939 narrative report for Pea Island Migratory Wildfowl Refuge provides a roster of army personnel and service personnel, a summary of camp life, a list of...

  13. The development of creativity of hig school students during a summer camp

    OpenAIRE

    ČEJKOVÁ, Iva

    2010-01-01

    This work is monitored from a professional point of view the area of creativity and its development on students during a summer camp. The theoretical part deals with the problems of creativity, its development and leisure activities. Research section includes a comprehensive weekly program that uses various methods to develop creativity, applied on the high school students during the summer camp activities. The aim of this study was to compare the methods used in terms of their impact on huma...

  14. Narratives from Jenin Refugee Camp: Children as extreme defence against the disintegration of family and community

    OpenAIRE

    Guido Veronese; Mahmud Shobi Said; Marco Castiglioni

    2010-01-01

    This paper aim to explore practices that create serious risks to the physical and psychological  health of Palestinian children. The typical stories of three children interviewed at Jenin Refugee Camp are subjected to content analysis. This analysis also extends to the micro and macro social developmental context of these children (which the share with the entire population of the camp). Key themes emerging from the analysis include the need to "redeem" grand parents and parents (de...

  15. Integrating Enhanced STEM Themes in the UTEP CAREERS Weather Camp for Youth

    Science.gov (United States)

    Güereque, M.; Olgin, J. G.; Kier, M. W.; Winston, C. E.; Fitzgerald, R. M.; Morris, V. R.

    2014-12-01

    The NOAA Center for Atmospheric Science (NCAS) sponsors a network of high school and middle school summer camps entitled "Channeling Atmospheric Research into Educational Experiences Reaching Students program, CAREERS". These camps are conducted nationwide at NCAS academic partners; the University of Texas at El Paso (UTEP), Howard University (HU), University of Puerto Rico at Mayagüez (UPRM), and Jackson State University (JSU). The goals of these camps are to increase the interest of secondary school (HS) students in atmospheric and weather related sciences, target under-represented students, and to ultimately boost their college enrollment in STEM related fields. For 2014 at UTEP, the annual student-outreach weather camp program underwent a thematic overhaul that sought to incorporate more of the geological and environmental context of the region. Doctoral students were allowed to assume greater responsibility for the design, development and implementation of the camp activities. The prevailing assumption was that these Ph.D. students were better suited for peer mentoring, bridging the age and interest gap, and delivering the material through the modern technologies and modes of communication. The redesigned approach focused on the identification of climate drivers within the region and this concept formed a thread throughout the planning and design of the camp modules. The outcome resulted in the incorporation of project based learning (PBL) activities, field excursions, and deployment of weather instrumentation, for explaining regional climate processes and events. Standardized surveys were administered to camp participants to evaluate the efficacy, as well as student perceptions of the camp and its activities. Results will be presented that are based on qualitative and quantitative analysis of student responses.

  16. Rapid tube CAMP test for identification of Streptococcus agalactiae (Lancefield group B).

    OpenAIRE

    Phillips, E. A.; Tapsall, J W; Smith, D D

    1980-01-01

    A rapid CAMP test for the presumptive identification of Streptococcus agalactiae (Lancefield group B) is described. Sheep erythrocytes, sensitized by staphylococcal beta-lysin and suspended in phosphate-buffered saline, were used to determine the lytic capacity of the neutralized supernatant fluids of 4-h broth cultures of streptococci being tested. A total of 96.2% of 130 group B streptococci gave positive CAMP tests, that is, lysis of the sheep erythrocytes after 10 min of exposure of strep...

  17. The clown at the gates of the camp : sovereignty, resistance and the figure of the fool.

    OpenAIRE

    Amoore, L.; Hall, A

    2013-01-01

    This article considers the figure of the clown-fool as a way of approaching anew contemporary practices of sovereignty and resistance. The spectre of the camp as the nomos of modern sovereign power is widely critiqued for its neglect of the thriving and teeming life that actually accompanies the declaration of exception. The clown is an errant and troublesome figure whose life haunts the sovereign decision on exception. His presence in border-camp activism invokes a rich, provocative history ...

  18. The Prevalence of Mental Health Problems in Rwandan and Burundese Refugee Camps

    OpenAIRE

    Jong, J. de; Scholte, W.F.; Koeter, M W; Hart, A A

    2000-01-01

    OBJECTIVE: We examined the prevalence of mental health problems in refugees living in camps that emerged in Tanzania during the Rwanda crisis that started in 1994. METHOD: Using the 28-item version of the General Health Questionnaire (GHQ-28), we examined two samples: a random sample (n = 854) and a sample of clients of a psychosocial support programme in these camps (n = 23). Sensitivity, specificity and positive- and negative predictive values were estimated for several cut-off scores of th...

  19. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

    OpenAIRE

    Park Sung-Jun; Ahmad Faiyaz; Philp Andrew; Baar Keith; Williams Tishan; Luo Haibin; Ke Hengming; Rehmann Holger; Taussig Ronald; Brown Alexandra L; Kim Myung K; Beaven Michael A; Burgin Alex B; Manganiello Vincent; Chung Jay H

    2012-01-01

    Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and antidiabetogenic properties. It is widely consumed as a nutritional supplement, but its mechanism of action remains a mystery. Here, we report that the metabolic effects of resveratrol result from competitive inhibition of cAMP-degrading phosphodiesterases, leading to elevated cAMP levels. The resulting activation of Epac1, a cAMP effector protein, increases intracellular Ca2...

  20. Role of Outreach Camps in Reducing the Burden of Cataracts in South India

    OpenAIRE

    Rajesh Nayak R; Ajay Kamath R; Madhurima Nayak A; Gurudutt Kamath M; Manjunath Kamath M; Susan D'Souza

    2014-01-01

    Aim: To establish the efficacy of rural outreach programme in reducing blindness caused by cataract by comparative analysis of visual outcome. Materials and Methods: Records of patients attending outreach camps conducted during 10 years i.e., 2001-02 to 2010-11 were studied. The total number of patients attending the camp and those who were detected to have visually significant cataract were noted. Similarly, the number of patients attending the outpatient department of the department of Opht...

  1. High levels of mortality, malnutrition, and measles, among recently-displaced Somali refugees in Dagahaley camp, Dadaab refugee camp complex, Kenya, 2011

    OpenAIRE

    Polonsky, Jonathan A.; Ronsse, Axelle; Ciglenecki, Iza; Rull, Monica; Porten, Klaudia

    2013-01-01

    Background Following a rapid influx of over 200,000 displaced Somalis into the Dadaab refugee camp complex in Kenya, Médecins Sans Frontières conducted a mortality and nutrition survey of the population living in Bulo Bacte, a self-settled area surrounding Dagahaley camp (part of this complex). Methods The survey was conducted between 31st July and 10th August 2011. We exhaustively interviewed representatives from all households in Bulo Bacte, collecting information on deaths, births, and pop...

  2. Improved molecular toolkit for cAMP studies in live cells

    Directory of Open Access Journals (Sweden)

    Nicol Xavier

    2011-07-01

    Full Text Available Abstract Background cAMP is a ubiquitous second messenger involved in a wide spectrum of cellular processes including gene transcription, cell proliferation, and axonal pathfinding. Precise spatiotemporal manipulation and monitoring in live cells are crucial for investigation of cAMP-dependent pathways, but existing tools have several limitations. Findings We have improved the suitability of cAMP manipulating and monitoring tools for live cell imaging. We attached a red fluorescent tag to photoactivated adenylyl cyclase (PACα that enables reliable visualization of this optogenetic tool for cAMP manipulation in target cells independently of its photoactivation. We show that replacement of CFP/YFP FRET pair with GFP/mCherry in the Epac2-camps FRET probe reduces photobleaching and stabilizes the noise level during imaging experiments. Conclusions The modifications of PACα and Epac2-camps enhance these tools for in vitro cAMP studies in cultured living cells and in vivo studies in live animals in a wide range of experiments, and particularly for long term time-lapse imaging.

  3. Improving Surgical Access in Rural Africa through a Surgical Camp Model.

    Science.gov (United States)

    Galukande, M; Kituuka, O; Elobu, E; Jombwe, J; Sekabira, J; Butler, Elissa; Faulal, J

    2016-01-01

    Introduction. Surgical camps are preplanned activities where volunteer surgical teams congregate at specified place(s) and perform a wide range of mostly elective procedures for a limited period of time. This is usually at no cost to the patients, who belong to vulnerable (poor and hard to reach) communities. We describe a surgical camp model and its challenges as a means of improving access to surgical services. Methods. A cross-sectional descriptive study. Data from a recent Association of Surgeons of Uganda surgical camp were collected and analyzed for demographics, costs, procedure types, and rates and, in addition, challenges encountered and solutions. Personnel that participated in this exercise included specialist surgeons, surgical residents, medical officers, clinical officers, anesthetists, and theater nurses (a total of 121 staff). Results. In total, 551 procedures were performed during a four-day-long camp. Mean age was 35 years (SD 23), M : F ratio was 2 : 1. Herniorrhaphy, skin lump excision, hydrocelectomy, and thyroidectomy formed 81% of all the procedures. Average cost per procedure was $73 USD. Conclusion. Surgical camps offer increased access to surgical services to vulnerable populations. Hernias and goiters were most common. Surgical camps should become an integral part of the Health Service delivery in low-resourced environments. PMID:27413775

  4. Epac and PKA: a tale of two intracellular cAMP receptors

    Institute of Scientific and Technical Information of China (English)

    Xiaodong Cheng; Zhenyu Ji; Tamara Tsalkova; Fang Mei

    2008-01-01

    cAMP-mediated signaling pathways regulate a multitude of important biological processes under both physiological and pathological conditions,including diabetes,heart failure and cancer.In eukaryotic cells,the effects of cAMP are mediated by two ubiquitously expressed intracellular cAMP receptors,the classic protein kinase A (PKA)/cAMP-dependent protein kinase and the recently discovered exchange protein directly activated by cAMP(Epac)/cAMP-regulated guanine nucleotide exchange factors.Like PKA,Epac contains an evolutionally conserved cAMP binding domain that acts as a molecular switch for sensing intracellular second messenger cAMP levels to control diverse biological functions.The existence of two families of cAMP effectors provides a mechanism for a more precise and integrated control of the cAMP signaling pathways in a spatial and temporal manner.Depending upon the specific cellular environments as well as their relative abundance,distrbution and localization,Epac and PKA may act independently,converge synergistically or oppose each other in regulating a specific cellular function.

  5. Impact of incarceration in Nazi concentration camps on multimorbidity of former prisoners

    Directory of Open Access Journals (Sweden)

    Jablonski RK

    2015-03-01

    Full Text Available Robert K Jablonski,1 Jerzy Leszek,2 Joanna Rosińczuk,3 Izabella Uchmanowicz,4 Bernard Panaszek11Department and Clinic of Internal Diseases, Geriatry and Allergology, 2Department of Psychiatry, 3Department of Nervous System Diseases, Department of Clinical Nursing, 4Division of Nursing in Internal Medicine Procedures, Department of Clinical Nursing, Wroclaw Medical University, Wroclaw, PolandObjective: To show the extent to which the health of former prisoners was affected by incarceration in extermination camps after 5 and 30 years of leaving the camp, and to determine the etiological factors underlying particular dysfunctions.Methods: Medical records of former prisoners developed in 1950 (n=250 and 1975 (n=120 were then, after several decades, retrospectively analyzed and compared with the control group, randomized and matched according to age, sex, occupation, and environment. None of the subjects in the control group was a prisoner either at a concentration camp or at any other prison or detention facility.Results: Multimorbidity affected mainly the central nervous system (CNS. Five years after leaving a camp, CNS dysfunctions were observed in 66% of former prisoners. Skeletal (42.4% and cardiovascular system (34.4% dysfunctions were the second and third most frequent dysfunctions. Thirty years after leaving a camp, the most prevalent coexisting conditions were also found within the CNS (80%, cardiovascular system (58.33%, and skeletal system (55%. Five and 30 years after leaving a camp, multiorgan lesions were found in 21.6% and 60% of survivors, respectively. Multimorbidity was more frequent in a group of prisoners who underwent the state of apathy and depression or who had been incarcerated longer than 24 months. The rate of CNS diseases was four times higher, and the rate of cardiovascular diseases or skeletal system dysfunctions was two times higher, in the study group after 30 years of leaving a camp compared with the control group

  6. Camp life: Are northern work camps safe havens for a migrant workforce, or dens of iniquity rampant with sex, drugs and alcohol?

    Energy Technology Data Exchange (ETDEWEB)

    Laverty, K.

    2004-02-01

    Two studies, dealing with life in work camps in northern Alberta and yielding contradictory results, are discussed. One study by a graduate student in sociology found that many of the men and women housed in work camps in remote locations of the northeastern oilsands belt use drugs, alcohol and casual sex to relieve boredom and loneliness. The other study, commissioned by the Athabasca Regional Issues Working Group (RWIG) found that camp workers visit Fort McMurray on the average of just over once a week, and use that time to take care of normal business, such as visiting health care professionals, buying gasoline, clothing, etc. It found no evidence of widespread sex, or drug or alcohol abuse among work camp residents. The RWIG study surveyed 25 per cent of the 6,272 worker population living in three camps in the Wood Buffalo region during June 2003. The study prepared by V. Taylor for a M.A. degree in sociology at the University of Calgary was severely criticized, primarily for its conclusions being based on a sample size of only nine men and one woman. Despite the criticism, the Taylor study made headlines across the country and has been instrumental in raising awareness of the special needs of a mobile workforce. A more broadly-based study is in progress at the University of Alberta, supported by the RCMP and a number of workplace stakeholders. Its objectives are to examine the situation more thoroughly, identify gaps in services and to explore long term solutions to what is undeniably a serious problem, indicated, if not proven, by the Taylor study.

  7. Developing water and sanitation services in refugee settings from emergency to sustainability - The case of Zaatari Camp in Jordan

    OpenAIRE

    van der Helm, A. W. C.; Bhai, A.; Coloni, F.; Koning, W.J.G.; De Bakker, P.T.

    2015-01-01

    Three years after Zaatari camp was established in the Hashemite Kingdom of Jordan, to host Syrian refugees, its population has grown to 82,000 persons. Zaatari is one of the largest refugee camps in the world, in one of the most water scarce areas on earth. Since its establishment, drinking water has been delivered by trucks to communal facilities across the camp. Wastewater is trucked out from these facilities, and from unregulated, self-constructed wastewater storages next to family househo...

  8. A Study to Explore the Lived Experience of Camping and Associated Effects of Escapism: A Green Exercise Approach

    OpenAIRE

    Morrow, Rosie

    2013-01-01

    Aims: The aim of the current study was to investigate the lived experience of camping, with a particular focus on the associated experiences of escapism, and the potential impact of camping on psychological health and wellbeing. Method: Four semi-structured interviews took place to gather data. Participants were asked to reflect on their most memorable camping experience, and through prompts and probes we were able to explore each experience fully. Following transcription, Colaizzi’s (1978) s...

  9. Assisting Groundwater Exploration for Refugee/IDP Camps by Remote Sensing and GIS

    Science.gov (United States)

    Wendt, Lorenz; Robl, Jörg; Hilberg, Sylke; Braun, Andreas; Rogenhofer, Edith; Dirnberger, Daniel; Strasser, Thomas; Füreder, Petra; Lang, Stefan

    2015-04-01

    Refugee camps and camps of internally displaced people (IDP) often form spontaneously or have to be established rapidly in remote, rural areas, where little is known about the hydrogeological situation. This requires a rapid assessment of the availability of groundwater to enable humanitarian organisations like Médecins Sans Frontières (MSF) to supply the camp population with sufficient potable water. Within the project EO4HumEn, hydrogeological reconnaissance maps are produced for MSF by integrating remote sensing data like SRTM, Landsat, ASTER, optical very-high resolution (VHR) imagery, and SAR data. Depending on the specific situation of the camps, these maps contain topography, permanent and temporary water bodies, hard rock outcrops and their geological variability, locations of existing boreholes and wells (if available), potential contamination sources, roads and obstacles (e.g. swampland). In areas characterized by unconsolidated sediments, specific landforms like alluvial fans, meanders, levees, deltas or beach ridges are identified. Here, the reconnaissance map can be sufficient to plan drill sites for groundwater abstraction. In hard rock areas, the lithology is determined, if the vegetation cover allows it. Fractures, faults and karst features are mapped to resolve the structural setting. Anomalous vegetation patterns are interpreted in terms of near-surface groundwater. The maps provide an overview of the camp surroundings, and allow the field hydrogeologists to focus their investigations on the most promising locations. The maps are complemented by a literature review on geological maps, articles and reports available for the area of interest. Assisting groundwater exploration by remote sensing data analysis is not a new development, but it has not been widely adopted by the humanitarian community as interfaces between humanitarian organisations and GI-scientists were missing. EO4HumEn fills this gap by a strong interdisciplinary cooperation

  10. Requirement of cAMP signaling for Schwann cell differentiation restricts the onset of myelination.

    Directory of Open Access Journals (Sweden)

    Ketty Bacallao

    Full Text Available Isolated Schwann cells (SCs respond to cAMP elevation by adopting a differentiated post-mitotic state that exhibits high levels of Krox-20, a transcriptional enhancer of myelination, and mature SC markers such as the myelin lipid galactocerebroside (O1. To address how cAMP controls myelination, we performed a series of cell culture experiments which compared the differentiating responses of isolated and axon-related SCs to cAMP analogs and ascorbate, a known inducer of axon ensheathment, basal lamina formation and myelination. In axon-related SCs, cAMP induced the expression of Krox-20 and O1 without a concomitant increase in the expression of myelin basic protein (MBP and without promoting axon ensheathment, collagen synthesis or basal lamina assembly. When cAMP was provided together with ascorbate, a dramatic enhancement of MBP expression occurred, indicating that cAMP primes SCs to form myelin only under conditions supportive of basal lamina formation. Experiments using a combination of cell permeable cAMP analogs and type-selective adenylyl cyclase (AC agonists and antagonists revealed that selective transmembrane AC (tmAC activation with forskolin was not sufficient for full SC differentiation and that the attainment of an O1 positive state also relied on the activity of the soluble AC (sAC, a bicarbonate sensor that is insensitive to forskolin and GPCR activation. Pharmacological and immunological evidence indicated that SCs expressed sAC and that sAC activity was required for morphological differentiation and the expression of myelin markers such as O1 and protein zero. To conclude, our data indicates that cAMP did not directly drive myelination but rather the transition into an O1 positive state, which is perhaps the most critical cAMP-dependent rate limiting step for the onset of myelination. The temporally restricted role of cAMP in inducing differentiation independently of basal lamina formation provides a clear example of the

  11. Refugees in and out North Africa: a study of the Choucha refugee camp in Tunisia.

    Science.gov (United States)

    Dourgnon, Paul; Kassar, Hassène

    2014-08-01

    In recent years, North African (NA) countries ceased to be emigration-only countries and are now on the verge of becoming immigration as well as transit countries for economic migrants and refugees. Contextual as well as structural long-term factors are driving these changes. The ongoing crises in Africa and the Middle East are prompting strong outflows of refugees, which are likely to induce NA countries to share some common public policy and public health concerns with European countries in a near future. This article highlights some aspects of these changes, from the study of the consequences of the 2011 Libyan crisis in Tunisia. It addresses individual trajectories and health concerns of refugees in and out North Africa from a study of the Choucha camp in Tunisia. The camp opened to immigrants from Libya during the 2011 crisis and accommodated the bulk of the refugees flow to Tunisia until July 2012. The study includes a monographic approach and a qualitative survey in the Choucha camp refugees. We describe the crisis history and the health response with a focus on the camp. We then address refugees' trajectories, and health needs and concerns from the interviews we collected in the camp in April 2012. PMID:25107992

  12. Persistent cAMP Signaling by Internalized LH Receptors in Ovarian Follicles.

    Science.gov (United States)

    Lyga, Sandra; Volpe, Silvia; Werthmann, Ruth C; Götz, Konrad; Sungkaworn, Titiwat; Lohse, Martin J; Calebiro, Davide

    2016-04-01

    A crucial event in female reproduction occurs at midcycle, when a LH peak induces the final maturation of ovarian follicles. LH signals via a G protein-coupled receptor selectively expressed in the outermost follicular cell layers. However, how LH signals are relayed inside these cells and finally to the oocyte is incompletely understood. Here, we monitored LH signaling in intact ovarian follicles of transgenic mice expressing a fluorescent cAMP sensor. We found that LH stimulation induces 2 phases of cAMP signaling in all cell layers surrounding the oocyte. Interfering with LH receptor internalization abolished the second, persistent cAMP phase and partially inhibited oocyte meiosis resumption. These data suggest that persistent cAMP signals from internalized LH receptors contribute to transmitting LH effects inside follicle cells and ultimately to the oocyte. Thus, this study indicates that the recently proposed paradigm of cAMP signaling by internalized G protein-coupled receptors is implicated in receptor function and is physiologically relevant. PMID:26828746

  13. cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia.

    Directory of Open Access Journals (Sweden)

    Yijin Tao

    Full Text Available The development of myopia is associated with decreased ocular scleral collagen synthesis in humans and animal models. Collagen synthesis is, in part, under the influence of cyclic adenosine monophosphate (cAMP. We investigated the associations between cAMP, myopia development in guinea pigs, and collagen synthesis by human scleral fibroblasts (HSFs. Form-deprived myopia (FDM was induced by unilateral masking of guinea pig eyes. Scleral cAMP levels increased selectively in the FDM eyes and returned to normal levels after unmasking and recovery. Unilateral subconjunctival treatment with the adenylyl cyclase (AC activator forskolin resulted in a myopic shift accompanied by reduced collagen mRNA levels, but it did not affect retinal electroretinograms. The AC inhibitor SQ22536 attenuated the progression of FDM. Moreover, forskolin inhibited collagen mRNA levels and collagen secretion by HSFs. The inhibition was reversed by SQ22536. These results demonstrate a critical role of cAMP in control of myopia development. Selective regulation of cAMP to control scleral collagen synthesis may be a novel therapeutic strategy for preventing and treating myopia.

  14. Intercellular redistribution of cAMP underlies selective suppression of cancer cell growth by connexin26.

    Directory of Open Access Journals (Sweden)

    Anjana Chandrasekhar

    Full Text Available Connexins (Cx, which constitute gap junction intercellular channels in vertebrates, have been shown to suppress transformed cell growth and tumorigenesis, but the mechanism(s still remain largely speculative. Here, we define the molecular basis by which Cx26, but less frequently Cx43 or Cx32, selectively confer growth suppression on cancer cells. Functional intercellular coupling is shown to be required, producing partial blocks of the cell cycle due to prolonged activation of several mitogenic kinases. PKA is both necessary and sufficient for the Cx26 induced growth inhibition in low serum and the absence of anchorage. Activation of PKA was not associated with elevated cAMP levels, but appeared to result from a redistribution of cAMP throughout the cell population, eliminating the cell cycle oscillations in cAMP required for efficient cell cycle progression. Cx43 and Cx32 fail to mediate this redistribution as, unlike Cx26, these channels are closed during the G2/M phase of the cell cycle when cAMP levels peak. Comparisons of tumor cell lines indicate that this is a general pattern, with growth suppression by connexins occurring whenever cAMP oscillates with the cell cycle, and the gap junction remain open throughout the cell cycle. Thus, gap junctional coupling, in the absence of any external signals, provides a general means to limit the mitotic rate of cell populations.

  15. Hydromania II: Journey of the Oncorhynchus. Summer Science Camp Curriculum 1994.

    Energy Technology Data Exchange (ETDEWEB)

    Moura, Joan; Swerin, Rod

    1995-01-01

    The Hydromania II curriculum was written for the third in a series of summer science camp experiences targeting students in grades 4--6 who generally have difficulty accessing supplementary academic programs. The summer science camp in Portland is a collaborative effort between Bonneville Power Administration (BPA), the US Department of Energy (DOE), and the Portland Parks and Recreation Community Schools Program along with various other cooperating businesses and organizations. The curriculum has also been incorporated into other summer programs and has been used by teachers to supplement classroom activities. Camps are designed to make available, affordable learning experiences that are fun and motivating to students for the study of science and math. Inner-city, under-represented minorities, rural, and low-income families are particularly encouraged to enroll their children in the program.

  16. Involvement of the second messenger cAMP in gravity-signal transduction in physarum

    Science.gov (United States)

    Block, I.; Rabien, H.; Ivanova, K.

    The aim of the investigation was to clarify, whether cellular signal processing following graviperception involves second messenger pathways. The test object was a most gravisensitive free-living ameboid cell, the myxomycete (acellular slime mold) Physarum polycephalum. It was demonstrated that the motor response is related to acceleration-dependent changes in the levels of the cellular second messenger cyclic adenosine monophosphate (cAMP). Rotating Physarum plasmodia in the gravity field of the Earth about a horizontal axis increased their cAMP concentration. Depriving the cells for a few days of the acceleration stimulus (near weightlessness in a space experiment on STS-69) slightly lowered plasmodial cAMP levels. Thus, the results provide first indications that the acceleration-stimulus signal transduction chain of Physarum uses an ubiquitous second messenger pathway.

  17. Modulation of adhesion-dependent cAMP signaling by echistatin and alendronate

    Science.gov (United States)

    Fong, J. H.; Ingber, D. E.

    1996-01-01

    We measured intracellular cAMP levels in cells during attachment and spreading on different extracellular matrix (ECM) proteins. Increases in cAMP were observed within minutes when cells attached to fibronectin, vitronectin, and a synthetic RGD-containing fibronectin peptide (Petite 2000), but not when they adhered to another integrin alpha nu beta 3 ligand, echistatin. Because echistatin also inhibits bone resorption, we measured the effects of adding another osteoporosis inhibitor, alendronate, in this system. Alendronate inhibited the cAMP increase induced by ligands that primarily utilize integrin alpha nu beta 3 (vitronectin, Peptite 2000), but not by fibronectin which can also use integrin alpha 5 beta 1. These results show that cell adhesion to ECM can increase intracellular cAPM levels and raise the possibility that inhibitors of osteoporosis may act, in part, by preventing activation of this pathway by integrins.

  18. [Miranda de Ebro: Medical condition of the concentration camp in the autumn of 1943].

    Science.gov (United States)

    Héraut, Louis-Armand

    2008-01-01

    Georges Morin's thesis (Algiers January 4 1944) allows to understand the sanitary conditions of the refugee camp at Miranda De Ebro (Spain) in the fall 1943. To avoid the Nazi occupation and the Obligatory Work Service in Germany 18,000 French got in Spain in 1943 and 10,000 including 39 physicians came through Miranda. The French were the majority and they created a Health Service separate from the official Spanish Health Service. The general dirtiness, the lack of water, the rudimentary conditions of lodging, the inadequacy and imbalance of food provoked two diseases among the young men: scabies and the so-called "mirandite" that is to say all the diarrheic diseases in the camp. Despite hard conditions of living the death rate in the camp remained smaller than crossing the Pyrenees from France where the danger threatened the escaped men. PMID:19230323

  19. Campers’ Characteristic, Recreation Activities and Related Forest Camping Attributes in Shah Alam Agriculture Park, Selangor

    Directory of Open Access Journals (Sweden)

    Abdullah Mohd

    2005-01-01

    Full Text Available A study was conducted to identify the campers’ backgrounds and their recreation participation pattern in camping site at Shah Alam Agriculture Park, Selangor. The study has found that the campers were comprised of well-educated youths with tertiary education background. They usually came during festive holiday break with their friends and most of them are the first time visitors. The results also indicated that most of them valued the natural beauty, cleanliness and maintenance in campsite, safety and friendly staff of the park. The main purpose of camping is to enjoy and experiencing nature, escape from daily stress and learning of new experience. In overall, it shows that the campers’ dynamics where their emphasis on the naturalness, cleanliness as well as provision of more activities (especially activities involving family recreation or group leadership camping programs and facilities (using actually tent instead of chalet would be the criteria to attract campers to this park.

  20. Regulation of cAMP Intracellular Levels in Human Platelets Stimulated by 2-Arachidonoylglycerol.

    Science.gov (United States)

    Signorello, Maria Grazia; Leoncini, Giuliana

    2016-05-01

    We demonstrated that in human platelets the endocannabinoid 2-arachidonoylglycerol (2-AG) decreased dose- and time-dependently cAMP intracellular levels. No effect on cAMP decrease induced by 2-AG was observed in the presence of the adenylate cyclase inhibitor SQ22536 as well in platelets pretreated with the thromboxane A2 receptor antagonist, SQ29548 or with aspirin, inhibitor of arachidonic acid metabolism through the cyclooxygenase pathway. An almost complete recovering of cAMP level was measured in platelets pretreated with the specific inhibitor of phosphodiesterase (PDE) 3A, milrinone. In platelets pretreated with LY294002 or MK2206, inhibitors of PI3K/AKT pathway, and with U73122, inhibitor of phospholipase C pathway, only a partial prevention was shown. cAMP intracellular level depends on synthesis by adenylate cyclase and hydrolysis by PDEs. In 2-AG-stimulated platelets adenylate cyclase activity seems to be unchanged. In contrast PDEs appear to be involved. In particular PDE3A was specifically activated, as milrinone reversed cAMP reduction by 2-AG. 2-AG enhanced PDE3A activity through its phosphorylation. The PI3K/AKT pathway and PKC participate to this PDE3A phosphorylation/activation mechanism as it was greatly inhibited by platelet pretreatment with LY294002, MK2206, U73122, or the PKC specific inhibitor GF109203X. Taken together these data suggest that 2-AG potentiates its power of platelet agonist reducing cAMP intracellular level. J. Cell. Biochem. 117: 1240-1249, 2016. © 2015 Wiley Periodicals, Inc. PMID:26460717

  1. Geophysical Summer Field Camp: Answering questions about the subsurface for the local community

    Science.gov (United States)

    van Wijk, K.; Batzle, M.; Liberty, L.; Raynolds, R.

    2008-12-01

    Summer Geophysics Field Camp is part of the core requirement for undergraduate Geophysics majors at Boise State University (CSM), as well as at Colorado School of Mines (CSM). We have found it to be most effectively taught when the target of the camp involves answering questions, which impact society. For example, currently the CSM/BSU geophysics summer camp focuses on ground water resources and geothermal potential in the Upper Arkansas River Basin, a part of the Rio Grande Rift system in Chaffee County, Colorado. A prime goal is to train students how to combine diverse sources of information into a unified interpretation: Students examine lithologies and structures on the periphery of the basin. Cross sections are constructed to predict the geophysical signature. Geophysical tools then are used to ascertain the gross structure and examine subsurface conditions in greater detail. These tools include surveying, regional gravity, deep and shallow seismic surveys, magnetics, DC resistivity, Ground Penetrating Radar, electromagnetics, hydrochemistry, and karaoke. While BSU and CSM own a considerable amount of geophysical hardware, our field camps are only possible because of extensive support by corporations and governmental agencies. In addition, the Society of Exploration Geohysics (SEG) Foundation provides financial support, Chaffee County assists with housing costs, and local land owners provide open access. In turn, the field camp results aid the community of Chaffee County in assessing their water resources for long term growth planning, as well as understanding the geothermal potential for hydroelectric power generation. BSU is currently exploring with the SEG Foundation under the Geophysicists Without Borders program to apply this model of combined education and social outreach in the form a geophysics camp for Southeast Asia, where we propose to study geohazards,geoarcheology and groundwater issues.

  2. Cooperation between cAMP signalling and sulfonylurea in insulin secretion.

    Science.gov (United States)

    Shibasaki, T; Takahashi, T; Takahashi, H; Seino, S

    2014-09-01

    Although glucose is physiologically the most important regulator of insulin secretion, glucose-induced insulin secretion is modulated by hormonal and neural inputs to pancreatic β-cells. Most of the hormones and neurotransmitters evoke intracellular signals such as cAMP, Ca²⁺ , and phospholipid-derived molecules by activating G protein-coupled receptors (GPCRs). In particular, cAMP is a key second messenger that amplifies insulin secretion in a glucose concentration-dependent manner. The action of cAMP on insulin secretion is mediated by both protein kinase A (PKA)-dependent and Epac2A-dependent mechanisms. Many of the proteins expressed in β-cells are phosphorylated by PKA in vitro, but only a few proteins in which PKA phosphorylation directly affects insulin secretion have been identified. On the other hand, Epac2A activates the Ras-like small G protein Rap in a cAMP-dependent manner. Epac2A is also directly activated by various sulfonylureas, except for gliclazide. 8-pCPT-2'-O-Me-cAMP, an Epac-selective cAMP analogue, and glibenclamide, a sulfonylurea, synergistically activate Epac2A and Rap1, whereas adrenaline, which suppresses cAMP production in pancreatic β-cells, blocks activation of Epac2A and Rap1 by glibenclamide. Thus, cAMP signalling and sulfonylurea cooperatively activate Epac2A and Rap1. This interaction could account, at least in part, for the synergistic effects of incretin-related drugs and sulfonylureas in insulin secretion. Accordingly, clarification of the mechanism of Epac2A activation may provide therapeutic strategies to improve insulin secretion in diabetes. PMID:25200305

  3. Professional burnout of personnel working in summer camps of people with disabilities

    Directory of Open Access Journals (Sweden)

    Giannia N.

    2011-10-01

    Full Text Available Introduction: Professional burnout constitutes a syndrome of physical and mental exhaustion occurring in working environment with symptoms that are present after frequent and long-term exposure in difficult working conditions especially in special education settings where a higher burnout in noticed due to tne nature of the profession. Purpose: The purpose of this study was to examine professional burnout of working personnel in summer camps for people with disabilities. Materials – Methods: The sample consisted of 35 participants (11 men and 25 women all camp personnel escorting people with disabilities in summer camps. Each participant completed the Maslach Burnout Inventory (Maslach & Jackson, 1986 comprised of 22 items that assess the variables of exhaustion, accomplishment and depersonalization. Omega total reliability analysis revealed an internal consistency ranging from good (ω total= .72 to high (ω total = .91 and a positive interaction between all factors. Independent samples t-test revealed differences personal accomplishment (t = -1.9 , df = 33, p = 0.32 και depersonalization t = -2.59 , df = 33, p = .014 according to participation in physical activity during the summer camp period. ANOVA analysis showed statistically significant differences in depersonalization (F (3, 33 = 2.81, p = .043, η2 =.076 , exhaustion (F (3, 33 = .335, p = .032, η2 =.084 , and personal accomplishment (F (3, 33 = 4.67, p = .008, η2 =.090 in relation to work satisfaction and type of disability. Conclusions: Professional burnout of personnel working in summer camps for people with disabilities appears high due to many hours and high working load that is affected by the nature of disability, participation of personnel in physical activities and their satisfaction derived from primary profession other than summer camp work.

  4. Marketingová strategie společnosti Camp Leaders s.r.o.

    OpenAIRE

    Švubová, Tereza

    2014-01-01

    The bachelor thesis deals with the marketing strategy of the company Camp Leaders s.r.o. in the Czech Republic. The main objective of the work is to analyse the marketing strategy. The first chapter explains some key concepts of marketing. The second chapter is dedicated to the introduction of the company Camp Leaders, part of the Smaller Earth. Then the second chapter analyses the marketing mix of this company and the main competitors of providing Work&Travel programmes are introduced. The m...

  5. Dermatologic challenges of health care for displaced people. lessons from a German emergency refugee camp

    OpenAIRE

    Uwe Wollina; Beatrix Gaber; Rahaf Mansour; Dana Langner; Gesina Hansel; André Koch

    2016-01-01

    Background: The World faces the highest waves of displaced people since World War II. There is limited knowledge about need of dermatological care for refugees and asylum seekers. Methods: We report the experience with a temporary emergency refugee camp in Dresden form the viewpoint of a hospital department. This is a descriptive report covering the period of 10 weeks. Results: In this refugee camp up to 1 100 people were hosted. The male to female ratio was 5.3. The majority of inhab...

  6. Intestinal parasitic infections in the residents of an emigration camp in Tijuana, Mexico.

    Science.gov (United States)

    Huh, S; Ahn, C; Chai, J Y

    1995-03-01

    We examined stool specimens of the residents in the emigration camp in Tijuana, Mexico for helminth eggs or protozoan cysts with formalin-ethyl acetate concentration method in February and July 1992. Out of 92 examined samples, number of positive was 49 (53.3%). While number of cumulative positive was 66 (71.7%). Cysts of Entamoeba coli (29.3%) Giardia lamblia (9.8%), Entamoeba histolytica (7.6%), and eggs of Taenia spp. (6.5) were most frequently observed. Filtered water supply and chemotherapy were required in this camp. PMID:7735788

  7. Effectiveness of a one-year multi-component day-camp intervention for overweight children

    DEFF Research Database (Denmark)

    Larsen, Kristian Traberg; Huang, Tao; Møller, Niels Christian;

    2014-01-01

    was offered two weekly hours of physical activity training for six weeks. The outcomes were measured at baseline and at six-week and 52-week follow-ups. Furthermore, BMI will be assessed again at 48-month follow-up. Test personnel were kept blinded. The intervention effect will be evaluated using......-camp intervention program on overweight children, due to the design and the follow-up period. Moreover, it will add to the knowledge on designing and implementing feasible camp settings for preventing overweight in children. TRIAL REGISTRATION: NCT01574352 at http://clinicaltrials.gov on the 8th of March 2012....

  8. Biophysical Techniques for Detection of cAMP and cGMP in Living Cells

    Directory of Open Access Journals (Sweden)

    Viacheslav O. Nikolaev

    2013-04-01

    Full Text Available Cyclic nucleotides cAMP and cGMP are ubiquitous second messengers which regulate myriads of functions in virtually all eukaryotic cells. Their intracellular effects are often mediated via discrete subcellular signaling microdomains. In this review, we will discuss state-of-the-art techniques to measure cAMP and cGMP in biological samples with a particular focus on live cell imaging approaches, which allow their detection with high temporal and spatial resolution in living cells and tissues. Finally, we will describe how these techniques can be applied to the analysis of second messenger dynamics in subcellular signaling microdomains.

  9. The research of teenager's physical development level in summer health tent camps.

    Directory of Open Access Journals (Sweden)

    Rybalko P.F.

    2011-05-01

    Full Text Available The problems of forming and content of physical-health work in scout camp organization are examined. In the research took part 230 pupils of 11 - 15 years old. The level of physical development and physical preparation of children is estimated; it is found out that majority of children have "lower that average level". The effectiveness of express-methodic that gives the estimation level of physical development and physical preparation of 11 - 15 years old schoolchildren is proved. Special complex of health physical training programmers for children summer camps is worked out.

  10. Communication and Shared Practices are Bringing NASA STEM Resources to Camp Youth

    Science.gov (United States)

    LaConte, K.; Shaner, A.; Shipp, S.; Garst, B.; Bialeschki, M. D.; Netting, R.; Erickson, K.

    2015-11-01

    In 2012, NASA and the American Camp Association (ACA) entered into an alliance to further both organizations' goals and objectives with regard to science, technology, engineering, and mathematics (STEM) education. This alliance is providing camp staff—and their young audiences—access to NASA's resources. NASA disseminates resources (e.g., pathways for requesting guest presenters, informal learning lesson plans), conducts ACA professional development (online and at ACA conferences), and coordinates efforts around key events (e.g., spacecraft launches). ACA promotes awareness of NASA resources through their communications and services. Together, the organizations are working to inspire a new generation of scientists, engineers, explorers, educators, and innovators to pursue STEM careers.

  11. Cartographies of the Political Camp of Afro-Descendents in Latin America

    OpenAIRE

    Agustín Lao-Montes

    2009-01-01

    This article lays out, in general terms, what it calls the political camp of Afro-descendents in Latin America. After establishing a series of theoretical and methodological criteria for the historical analysis of black movements in modernity and the Afro-American movements in particular, the article focuses on the emergence of afro-descendant movements in Latin America during the last part of the 1980s. One of the principal arguments is that in the 1990s a political camp of afro-descendents ...

  12. Developing water and sanitation services in refugee settings from emergency to sustainability - The case of Zaatari Camp in Jordan

    NARCIS (Netherlands)

    Van der Helm, A.W.C.; Bhai, A.; Coloni, F.; Koning, W.J.G.; De Bakker, P.T.

    2015-01-01

    Three years after Zaatari camp was established in the Hashemite Kingdom of Jordan, to host Syrian refugees, its population has grown to 82,000 persons. Zaatari is one of the largest refugee camps in the world, in one of the most water scarce areas on earth. Since its establishment, drinking water ha

  13. Nobody Can See Atoms: Science Camps Highlighting Approaches for Making Chemistry Accessible to Blind and Visually Impaired Students

    Science.gov (United States)

    Wedler, Henry B.; Boyes, Lee; Davis, Rebecca L.; Flynn, Dan; Franz, Annaliese; Hamann, Christian S.; Harrison, Jason G.; Lodewyk, Michael W.; Milinkevich, Kristin A.; Shaw, Jared T.; Tantillo, Dean J.; Wang, Selina C.

    2014-01-01

    Curricula for three chemistry camp experiences for blind and visually impaired (BVI) individuals that incorporated single- and multiday activities and experiments accessible to BVI students are described. Feedback on the camps from students, mentors, and instructors indicates that these events allowed BVI students, who in many cases have been…

  14. Camp Creates a World of Magic: The Trail to Innovative Thinking Begins at the ACA National Conference.

    Science.gov (United States)

    Coleman, Marla

    2001-01-01

    The American Camping Association 2001 National Conference at Walt Disney World draws parallels between the administration of camp programs and practices at Disney World. Seminars led by Disney managers focus on recruitment of college students, development of a corporate culture and philosophy, emphasis on environment, and quality service that…

  15. Development and evaluation of a learner-centered educational summer camp program on soft skills for baccalaureate nursing students.

    Science.gov (United States)

    Lau, Ying; Wang, Wenru

    2014-01-01

    The objectives were to develop a learner-centered educational camp program for nursing students and to evaluate 4 areas of soft skills, communication ability, clinical interaction, interpersonal relationships, and social problem solving, before and after the program. The results showed that the summer camp program was effective in improving nursing students' soft skills. PMID:24978015

  16. Democracy Camp for Teachers: Cross-Cultural Professional Development for Preparing Educators to Create Social Justice-Minded Citizens

    Science.gov (United States)

    Burroughs, Susie; Hopper, Peggy F.; Brocato, Kay; Webeck, Mary Lee

    2009-01-01

    The Civitas Democracy Camp for Teachers provides professional development for educators to collaboratively explore ideals of citizenship and citizenship education in democratic societies. Reported herein are the findings of a study of the camp experience of a cross-cultural group of educators who examined the concept of social justice and ways to…

  17. High incidence of subcutaneous emphysema in children in a Somali refugee cAMP during measles outbreak.

    OpenAIRE

    Moons, Peter; Thallinger, Monica

    2014-01-01

    During an outbreak of measles in a refugee camp in Ethiopia, 9 patients (age range 4 months to 18 years) were diagnosed with subcutaneous emphysema. Incidence of this rare complication of measles in this refugee camp was higher than previously reported. We hypothesize that the high incidence is most likely related to poor physical state of the refugee population with high rates of malnutrition.

  18. Camp of Hip-Hop - kõigile kohustuslik / Mari Hiiemäe ; kommenteerinud Joel Juht

    Index Scriptorium Estoniae

    Hiiemäe, Mari

    2012-01-01

    Üheksandat korda toimuvast rahvusvahelisest tantsulaagrist ja tänavakultuuri tutvustavast noortelaagrist Camp of Hip-Hop, mis toimub Lääne Virumaal Käsmus. 28. juunil toimub kõigile huvilistele meelelahutusüritus Camp of Hip-Hop Championships, kus näitavad oma tantsuoskusi laagris osalejad ja maailmas tunnustatud koreograafid

  19. Change Agent Research on the BANA-Can/Am Summer Camp for Young People with Eating Disorders.

    Science.gov (United States)

    Moriarty, Dick; And Others

    This document reports on the model and method used to design, implement, coordinate, and evaluate a summer camp for young people with eating disorders. The basic approach used at the camp is described as the Sports Institute for Research model, a systems analysis model which focuses on: (1) the ultimate goal or mission; (2) obstacles or problems…

  20. Rethinking the roles of CRP, cAMP, and sugar-mediated global regulation in the Vibrionaceae.

    Science.gov (United States)

    Colton, Deanna M; Stabb, Eric V

    2016-02-01

    Many proteobacteria modulate a suite of catabolic genes using the second messenger cyclic 3', 5'-AMP (cAMP) and the cAMP receptor protein (CRP). Together, the cAMP-CRP complex regulates target promoters, usually by activating transcription. In the canonical model, the phosphotransferase system (PTS), and in particular the EIIA(Glc) component for glucose uptake, provides a mechanistic link that modulates cAMP levels depending on glucose availability, resulting in more cAMP and activation of alternative catabolic pathways when glucose is unavailable. Within the Vibrionaceae, cAMP-CRP appears to play the classical role in modulating metabolic pathways; however, it also controls functions involved in natural competence, bioluminescence, pheromone signaling, and colonization of animal hosts. For this group of marine bacteria, chitin is an ecologically relevant resource, and chitin's monomeric sugar N-acetylglucosamine (NAG) supports robust growth while also triggering regulatory responses. Recent studies with Vibrio fischeri indicate that NAG and glucose uptake share EIIA(Glc), yet the responses of cAMP-CRP to these two carbon sources are starkly different. Moreover, control of cAMP levels appears to be more dominantly controlled by export and degradation. Perhaps more surprisingly, although CRP may require cAMP, its activity can be controlled in response to glucose by a mechanism independent of cAMP levels. Future studies in this area promise to shed new light on the role of cAMP and CRP. PMID:26215147

  1. Writing and Teaching behind Barbed Wire: An Exiled Composition Class in a Japanese-American Internment Camp

    Science.gov (United States)

    Wu, Hui

    2007-01-01

    By reflecting on Japanese internment camps executed by the U.S. government in World War II, this article examines camp schools' curricula and writing assignments and an English teacher's response to student essays to show how racially profiled students and their Caucasian teacher negotiated the political meanings of civil rights and freedom.…

  2. Effects of a multi-component camp-based intervention on inflammatory markers and adipokines in children

    DEFF Research Database (Denmark)

    Huang, T.; Larsen, K. T.; Moller, N. C.;

    2015-01-01

    Objective. To examine the effects of a multi-component camp-based intervention on inflammatory markers and adipokines in children. Methods. One hundred and fifteen children were recruited in Odense, Denmark (2012-2014). The participants were randomly allocated to either the day camp intervention ...

  3. An evaluation of productivity and mortality factors influencing goose populations: A status report of the 1984 waterfowl monitoring effort at Old Chevak field camp

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — During spring and summer 1984 data were obtained from nine field camps located on the Yukon Delta National Wildlife Refuge one cooperative camp and eight refuge...

  4. Evaluation Report of the Ontario Camp Leadership Centre at Bark Lake.

    Science.gov (United States)

    Applied Research Consulting House Ltd., Mississauga (Ontario).

    Both participants in the Ontario Camp Leadership Center at Bark Lake and their sponsoring organizations agreed on the benefits of the leadership development experience and enthusiastically endorsed the program. Researchers conducted a 19-question telephone survey of 202 program participants and a 32-question survey of 40 sponsors and 20…

  5. [Odontological contribution to the identification of concentration camp physician Josef Mengele].

    Science.gov (United States)

    Endris, R

    1985-01-01

    The body which had been exhumed from a graveyard in Embú (Brazil) on June 6th was investigated by forensic experts. The comparison of the post-mortem dental findings and jaw bones with ante-mortem data of Josef Mengele, physician of the concentration camp of Auschwitz, makes evident, that there is positive identity by high probability. PMID:3911920

  6. 36 CFR 13.1116 - Do I need a camping permit in Glacier Bay?

    Science.gov (United States)

    2010-07-01

    ... Glacier Bay? 13.1116 Section 13.1116 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Glacier Bay National Park and Preserve General Provisions § 13.1116 Do I need a camping permit in Glacier Bay? From May...

  7. Education in the field: The making of the High Desert Youth Range Camp

    Science.gov (United States)

    In June 2011 sixteen high school age students from Oregon and Idaho participated in a youth oriented camp specifically focusing on rangeland science at the Northern Great Basin Experimental Range near Burns, OR. Rangeland professionals came together to develop a remarkable experience for youth inter...

  8. An innovative summer camp program improves weight and self-esteem in obese children

    Science.gov (United States)

    Obese children benefit from structured life-style changes and need help with self-esteem, which is lower when compared to normal-weight children. Summer camp might offer an opportunity to achieve a healthy lifestyle and to improve weight and self-esteem. he objective is to determine the effectivenes...

  9. 75 FR 62755 - Mt. Hood National Forest, Oregon; Cooper Spur-Government Camp Land Exchange

    Science.gov (United States)

    2010-10-13

    .... L. 111-11, 129 Stat. 1019) The legislation also states that a trail easement be used at the... Camp may result in no net loss of wetlands. Cultural and Heritage resource surveys were conducted on... Preservation Officer (SHPO) consultation. Trails 755, 755A, and 755B cross the Federal parcels. A...

  10. Evidence for cAMP as a mediator of gonadotropin secretion from female pituitaries

    International Nuclear Information System (INIS)

    Sodium flufenamate, which inhibited gonadotropin-releasing hormone (GnRH)-stimulated increases in adenosine 3',5'-cyclic monophosphate (cAMP), was used to evaluate the potential role of cAMP as a mediator of GnRH-stimulated gonadotropin secretion. Quartered pituitaries from diestrous II female rats were perifused at 370C, and sequential effluent fractions were collected every 10 min. Administration of GnRH resulted in a characteristic biphasic response for both luteinizing hormone (LH) and follicle-stimulating hormone (FSH), whereas 5 μM cycloheximide inhibited the secondary augmented responses (phase II) of both hormones. Infusions of 0.1 mM flufenamate inhibited GnRH-stimulated gonadotropin secretion in a manner similar to that of cycloheximide, whereas the administration of 5 mM dibutyryl cAMP in combination with GnRH and flufenamate resulted in the restoration of LH and FSH secretion. The dibutyryl cAMP-restored response appeared to be protein synthesis dependent and specific for cAMP. These results suggest that although the cyclic nucleotide is not involved in the acute release of LH and FSH, it does appear to play a pivotal but indirect role in phase II release of the hormones, by effects involving the stimulation of de novo protein synthesis

  11. 14 CFR 91.1433 - CAMP: Maintenance and preventive maintenance training program.

    Science.gov (United States)

    2010-01-01

    ... maintenance training program. Each program manager who maintains program aircraft under a CAMP or a person performing maintenance or preventive maintenance functions for it must have a training program to ensure that... maintenance training program. 91.1433 Section 91.1433 Aeronautics and Space FEDERAL AVIATION...

  12. Adenyl cyclases and cAMP in plant signaling - Past and present

    KAUST Repository

    Gehring, Christoph A

    2010-06-25

    In lower eukaryotes and animals 3\\'-5\\'-cyclic adenosine monophosphate (cAMP) and adenyl cyclases (ACs), enzymes that catalyse the formation of cAMP from ATP, have long been established as key components and second messengers in many signaling pathways. In contrast, in plants, both the presence and biological role of cAMP have been a matter of ongoing debate and some controversy. Here we shall focus firstly on the discovery of cellular cAMP in plants and evidence for a role of this second messenger in plant signal transduction. Secondly, we shall review current evidence of plant ACs, analyse aspects of their domain organisations and the biological roles of candidate molecules. In addition, we shall assess different approaches based on search motifs consisting of functionally assigned amino acids in the catalytic centre of annotated and/or experimentally tested nucleotide cyclases that can contribute to the identification of novel candidate molecules with AC activity such as F-box and TIR proteins. 2010 Gehring; licensee BioMed Central Ltd.

  13. All Write - Virginia Tech to host creative writing camp in June

    OpenAIRE

    Elliott, Jean

    2005-01-01

    Virginia Tech's department of English will hold a week-long writing camp for youth this summer. Targeted for ages 8-18, All Write will be held from June 20-24. Participants can opt to focus on poetry, fiction, or non-fiction writing.

  14. Rural Camp School Eco Learn--Outdoor Education in Rural Settings

    Science.gov (United States)

    Smeds, Pia; Jeronen, Eila; Kurppa, Sirpa; Vieraankivi, Marja-Liisa

    2011-01-01

    Outdoor education in rural and agricultural surroundings offers many possibilities for learning and studying different school subjects as well as teaching. This study aims to explore the development of an educational rural camp school, Eco Learn, and to investigate pupils' expectations and experiences and teachers' experiences of carrying out the…

  15. Identity Development of Youth during Participation at an Informal Science Education Camp

    Science.gov (United States)

    Riedinger, Kelly

    2015-01-01

    In this exploratory case study, I investigated the ways that youth engaged in negotiating their identity during learning conversations at an informal science education camp. In particular, I was interested in exploring the ways that youth positioned themselves within their learning group and how this influenced their identities as learners of…

  16. Teachable Moments in Jewish Education: An Informal Approach in a Reform Summer Camp

    Science.gov (United States)

    Cohen, Erik H.; Bar-Shalom, Yehuda

    2010-01-01

    Utilizing "teachable moments" within daily situations to impart knowledge and transmit values is a type of informal education. In a structured camp environment, such teachable moments may be integrated into the educational curriculum. "Jewish teachable moments" may be used to address Judaism and Jewish Peoplehood holistically, as the educators and…

  17. Malnourished Children in Refugee Camps and Lack of Connection with Services After US Resettlement

    Science.gov (United States)

    Cookson, Susan T.; Talley, Leisel; Rochat, Roger

    2016-01-01

    Identifying and addressing malnutrition among US-bound refugee children is an important human rights issue. Failure to address childhood malnutrition can impair cognitive development and productivity. The target population was children aged 6–59 months, originating from eight countries representing 51 % of US-resettled refugees for 2005–2011, living in 22 camps prior to potential US-resettlement. The corresponding camp-level nutritional survey data were evaluated. State Refugee Health Coordinators were surveyed on nutritional assessment, reporting and referrals for their US-refugee medical screenings. From 2004 to 2010, half of the camps (63 total surveys) had global acute malnutrition prevalence over 15 % at least once (surveys not done annually) and anemia prevalence greater than 40 %. The majority of US-refugee medical screenings included height and weight measurements but few used national or WHO standards to evaluate presence or level of malnutrition. Improve overseas camp monitoring and link these nutritional data to US-resettling refugee children to inform potential nutritional interventions. Domestically, use WHO or US growth standards for anthropometrics to determine presence of malnutrition and need for corrective action. PMID:23430464

  18. Outdoor Centers and Camps: A 'Natural' Location for Youth Leadership Development. ERIC Digest.

    Science.gov (United States)

    Kielsmeier, James C.

    This digest offers camp leaders, outdoor experiential educators, school and college faculty, or youth agency staff who are interested in nurturing youth leaders a framework for designing youth leadership programs which employ an outdoor setting as a "leadership classroom." Basic categories for leadership theory are defined: trait theory,…

  19. A community-based cervical cancer screening program among women of Delhi using camp approach

    Directory of Open Access Journals (Sweden)

    Sharma Pragya

    2010-01-01

    Full Text Available Background: Cervical cancer is the commonest malignancy among women in developing countries. Cytological screening (Pap smear have been claimed to reduce incidence and mortality of carcinoma cervix significantly for which sensitization of women is required through community-based approach. Objectives: To find out number of cervical cancer cases among patients reporting to a general health care camp through screening program and study the prevalence of perceived morbidity and its confirmation. Settings: Cross-sectional study among women attending cancer awareness camps. Materials and Methods: A total of 435 women attending cancer awareness camps were screened for carcinoma cervix. The findings of history and clinical examination were recorded. Pap smears of all the symptomatic patients were collected and cytological diagnosis was confirmed by a pathologist. Results and Conclusions: The perceived gynecological morbidity was observed to be 59.8%. The smear of the women who were suspected of carcinoma on clinical examination was confirmed to be the cases of carcinoma-in-situ (7.8% and high-grade neoplasia (2.9% on laboratory investigations. The findings of the study highlight the utility and need of cancer cervix screening among the women at regular intervals through camp approach in the community.

  20. 78 FR 41720 - CampCo Petition to Allow Commercial Distribution of Tritium Markers

    Science.gov (United States)

    2013-07-11

    ...; ] NUCLEAR REGULATORY COMMISSION 10 CFR Part 32 CampCo Petition to Allow Commercial Distribution of Tritium... commercial distribution of tritium markers for use under exemption from licensing requirements. DATES: Submit... allow the commercial distribution of tritium markers for use under exemption from licensing...

  1. Effects of radioprotectors on the cAMP and cGMP systems

    International Nuclear Information System (INIS)

    The sulphur-containing radioprotectors mercaptoethylamine (MEA), aminoethylisothiourea (AET), 2-aminothiazoline, 4-oxo-2-amino-thiazoline, and S-S-oxapentane-1,5-diisorthiourea, and the radioprotective biogenic amines serotonin, histamine, and dopamine, caused the elevation of cAMP content and intensified the rate of cAMP-dependent protein phosphorylation in tissues of animals following intraperitoneal injection at radioprotective doses. Biogenic amines stimulated the adenylate cyclase activity in membrane preparations from liver, spleen, and small-intestine mucosa; sulphur-containing radioprotectors caused no such effects. None of the radioprotectors affected CAMP and cGMP phosphodiesterases in vitro. AET and MEA inhibited guanylate cyclase in vitro, whereas serotonin and dopamine stimulated the enzyme. A biphasic change in the level of cGMP was observed in tissues after the administration of MEA and AET (more than 2-fold fally by 1-3 min after the administration of drug and 1.4-fold rise after 15-20 min); serotonin and dopamine caused a slow rise in the cGMP level, the cAMP/cGMP ratio in liver showed biphasic changes in level during the 20 min following injection of serotonin. The data obtained support the conclusion that the action of radioprotectors on cellular metabolism in animals may be mediated by the cAMP system.The reciprocal regulation of radioresistance by cAMP and cGMP is unlikely to exist. (orig.)

  2. Offering a Forensic Science Camp To Introduce and Engage High School Students in Interdisciplinary Science Topics

    DEFF Research Database (Denmark)

    Ahrenkiel, Linda; Worm-Leonhard, Martin

    2014-01-01

    In this article, we present details of a one-week interdisciplinary science camp for high school students in Denmark, “Criminal Camp”. We describe the use of forensic science and simulated crimes as a common foundation for teaching the theory and practice of concepts in chemistry, physics...

  3. THE SPORTS CAMP – FUNCTIONING SPECIFIC AND MANAGERIAL SPECIFIC IN THE GLOBALIZATION CONTEXT

    Directory of Open Access Journals (Sweden)

    Nichifor Florin

    2014-03-01

    Full Text Available The purpose of the research is to analyze the elements of cultural specificity of the OglinziTârguNeamţ sports camp, with a focus on the following aspects: the activity of the manager and of the managerial team, employees’ attitude, the behaviour of clients (children, students, young people, teenagers, athletes, the mental, behavioural, and attitudinal conditions in the context of globalization. Usually considered by children and teenagers the most exciting and attractive space, the camp attracts people every year, thus “producing” the most beautiful and intense memories. The camp is the place where the clients look for sports activity, relaxation, entertainment, and rest. At the same time, it becomes, for a shorter or longer period, a special institution, a community. For any client, the camp means emotion, surprise, knowledge, meeting expectations. The client also has the possibility of developing practical (sports and communicational skills, of getting used to the spirit of teamwork, of expressing and developing new creative skills, of getting in contact with the customs, traditions, and culture of the area.

  4. Malnourished children in refugee camps and lack of connection with services after US resettlement.

    Science.gov (United States)

    Lutfy, Caitlyn; Cookson, Susan T; Talley, Leisel; Rochat, Roger

    2014-10-01

    Identifying and addressing malnutrition among US-bound refugee children is an important human rights issue. Failure to address childhood malnutrition can impair cognitive development and productivity. The target population was children aged 6-59 months, originating from eight countries representing 51 % of US-resettled refugees for 2005-2011, living in 22 camps prior to potential US-resettlement. The corresponding camp-level nutritional survey data were evaluated. State Refugee Health Coordinators were surveyed on nutritional assessment, reporting and referrals for their US-refugee medical screenings. From 2004 to 2010, half of the camps (63 total surveys) had global acute malnutrition prevalence over 15 % at least once (surveys not done annually) and anemia prevalence greater than 40 %. The majority of US-refugee medical screenings included height and weight measurements but few used national or WHO standards to evaluate presence or level of malnutrition. Improve overseas camp monitoring and link these nutritional data to US-resettling refugee children to inform potential nutritional interventions. Domestically, use WHO or US growth standards for anthropometrics to determine presence of malnutrition and need for corrective action. PMID:23430464

  5. Revisiting the magnetostratigraphy of the Central Atlantic Magmatic Province (CAMP) in Morocco

    Czech Academy of Sciences Publication Activity Database

    Font, E.; Youbi, N.; Fernandes, S.; El Hachimi, H.; Kratinová, Zuzana; Hamim, Y.

    2011-01-01

    Roč. 309, č. 3-4 (2011), s. 302-317. ISSN 0012-821X Institutional research plan: CEZ:AV0Z30120515 Keywords : CAMP * Morocco * remagnetization * magnetostratigraphy * Triassic-Jurassic boundary Subject RIV: DB - Geology ; Mineralogy Impact factor: 4.180, year: 2011

  6. Serving At-Risk Youth at Camp: Understanding This Population and Meeting Their Needs.

    Science.gov (United States)

    Grayson, Randall

    2001-01-01

    Defines "at-risk youth." Describes characteristics of resilient children and their families, friends and mentors, schools, and communities. Discusses camp program practices that have been shown to promote resiliency: focus on youth development, intentional processes that target the personal domain, organizational elements borrowed from successful…

  7. Summer Camp to Engage Students in Nutritional Chemistry Using Popular Culture and Hands-On Activities

    Science.gov (United States)

    Skluzacek, Joanna M.; Harper, Joshua; Herron, Emily; Bortiatynski, Jacqueline M.

    2010-01-01

    Action Potential Science Experience (APSE) is a five-day summer camp offering science opportunities for K-8 students. The focus of the APSE curriculum is to teach science concepts and methods while challenging the participants to solve an overarching problem from the popular-culture context. The participants in the APSE entitled Burger 'N Fries…

  8. Burnout Among Summer Camp Staff Supporting People with Intellectual Disability and Aggression

    Science.gov (United States)

    Ko, Clara; Lunsky, Yona; Hensel, Jennifer; Dewa, Carolyn S.

    2012-01-01

    Studies have shown that there is an association between exposure to people with intellectual disability who are aggressive and burnout in the staff who support them. Little is known, however, about the experience of summer camp staff who work with this population. This study examined the relationship between aggression and burnout in 169 staff…

  9. 75 FR 3212 - Office of Elementary and Secondary Education; College Assistance Migrant Program (CAMP)

    Science.gov (United States)

    2010-01-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION Office of Elementary and Secondary Education; College Assistance Migrant Program (CAMP) Catalog of... Register (74 FR 66300) a notice inviting applications for new awards for FY 2010. The notice specified...

  10. The Rise and Fall of Boot Camps: A Case Study in Common-Sense Corrections

    Science.gov (United States)

    Cullen, Francis T.; Blevins, Kristie R.; Trager, Jennifer S.; Gendreau, Paul

    2005-01-01

    "Common sense" is often used as a powerful rationale for implementing correctional programs that have no basis in criminology and virtually no hope of reducing recidivism. Within this context, we undertake a case study in "common-sense' corrections by showing how the rise of boot camps, although having multiple causes, was ultimately legitimized…

  11. Video podcasts as a long-distance outreach tool: Polar science from Byrd Camp, West Antarctica

    Science.gov (United States)

    Berg, M.; Science; Engineering Team Of Polenet Field Seasons 2009-10; 2010-11

    2011-12-01

    Video Podcasts offer a unique opportunity to actively engage the public in ongoing research projects by revealing faces and stories from field, lab and engineering efforts that often happen behind the scenes. Podcasts thus allow the science community to not only present their accomplishments, but also the where, how and why. Publishing these videos in real time while stationed at remote field camps brings particular challenges to the process. This was the case during the POLNET (Polar Earth Observing Network) field seasons at Byrd Camp, West Antarctica. With no internet connection and limited flights in and out of camp, the team worked to produce a series of Video Podcast field updates that were flown to McMurdo Station and uploaded to a web server off the continent. These videos provided glimpses of living and working on a remote ice sheet while installing GPS and seismic stations. At a time when climate science is under extreme scrutiny, this project offered a tangible and human view of efforts to model how ice masses are changing. In any science education effort, the risk of diluting the science until it is no longer meaningful poses certain challenges. At the same time, going into great depth about the methods and theories using technical vocabulary can immediately turn away an audience that is already inundated with information. These videos represent an attempt to creatively and accurately present scientific concepts in short, digestible segments that bring elements of fun from the unique field setting and personalities of Byrd Camp, West Antarctica.

  12. Breaking Down the Stigma of Mental Illness through an Adventure Camp: A Collaborative Education Initiative.

    Science.gov (United States)

    Stuhlmiller, Cynthia M.

    2003-01-01

    Describes an outdoor adventure camp to help mental health consumers and nursing students explore the issues of mental health and illness through experiential and perceived risk challenges. Evaluation data reveals a breakdown in the stigma of mental illness as consumers and students came to know, trust, and count on each other in order to succeed…

  13. Senior Thesis Camp: Partnerships in Practice at the University of Notre Dame

    Science.gov (United States)

    Smith, Cheri; Kayongo, Jessica

    2011-01-01

    The article describes the process of developing a week long thesis camp for seniors in the College of Arts and Letters at the University of Notre Dame. The library and other university groups worked together to provide the students with workshops, ready access to research assistance, and dedicated space to work on their theses. This inaugural…

  14. Anagrelide, a potent inhibitor of platelet aggregation, inhibits inositol phosphate generation and elevates cAMP

    International Nuclear Information System (INIS)

    The effects of the potent platelet aggregation inhibitor, anagrelide (6,7-dichloro-1,5-dihydroimidazo[2,1-6]quinazolin-2(3H)-one monohydrochloride; BL-4162A), on polyphosphoinositide metabolism in human platelets was investigated. Anagrelide maximally inhibited the thrombin-stimulated increase in inositol phosphates (IPn) at approximately 3.3 x 10-6M. The time of incubation required for a maximal response was between 15 and 30 min. Since anagrelide has been reported to inhibit low-Km cAMP phosphodiesterase, the authors compared its ability to inhibit stimulated IPn to that of the well known cAMP phosphodiesterase inhibitor IBMX. Both compounds inhibited IPn similarly except in experiments in which the IP phosphatase inhibitor, lithium chloride, was omitted. In these experiments, anagrelide totally inhibited, while IBMX only partially inhibited, the thrombin-stimulated elevation of IPn. The effect of anagrelide on platelet cyclic nucleotide levels was also measured. After 30 min incubation, concentrations of anagrelide which maximally inhibit aggregation induced a 2-fold increase in cAMP without significantly altering cGMP. These results suggest the mechanism of platelet aggregation inhibition includes an anagrelide-induced elevation of cAMP

  15. Effect of an Engineering Camp on Students' Perceptions of Engineering and Technology

    Science.gov (United States)

    Hammack, Rebekah; Ivey, Toni A.; Utley, Juliana; High, Karen A.

    2015-01-01

    Students' knowledge about a profession influences their future decisions about careers. Research indicates that students tend to hold stereotypical views of engineers, which would hinder engineering as a career choice. The purpose of this study was to measure how participating in a week long engineering summer camp affected middle school students'…

  16. Proteomic signatures implicate cAMP in light and temperature responses in Arabidopsis thaliana

    KAUST Repository

    Thomas, Ludivine

    2013-05-01

    The second messenger 3\\'-5\\'-cyclic adenosine monophosphate (cAMP) and adenylyl cyclases (ACs), enzymes that catalyse the formation of cAMP from ATP, are increasingly recognized as important signaling molecules in a number of physiological responses in higher plants. Here we used proteomics to identify cAMP-dependent protein signatures in Arabidopsis thaliana and identify a number of differentially expressed proteins with a role in light- and temperature-dependent responses, notably photosystem II subunit P-1, plasma membrane associated cation-binding protein and chaperonin 60 β. Based on these proteomics results we conclude that, much like in cyanobacteria, algae and fungi, cAMP may have a role in light signaling and the regulation of photosynthesis as well as responses to temperature and we speculate that ACs could act as light and/or temperature sensors in higher plants. Biological significance: This current study is significant since it presents the first proteomic response to cAMP, a novel and key second messenger in plants. It will be relevant to researchers in plant physiology and in particular those with an interest in second messengers and their role in biotic and abiotic stress responses. © 2013 Elsevier B.V.

  17. An innovative summer camp program improves weight and self-esteem in obese children

    Science.gov (United States)

    To determine the potential benefits of a residential summer camp to treat childhood obesity, 21 obese, multiethnic children (aged 11.4 +/- 1.4 years; body mass index [BMI] percentile 98.5 +/- 1.4; BMI z score 2.30 +/- 0.33) from a diverse socioeconomic background were enrolled in a 2-week summer cam...

  18. Exploring the "Black Box" of Programming: Applying Systematic Implementation Evaluation to a Structured Camp Curriculum

    Science.gov (United States)

    Mainieri, Tracy L.; Anderson, Denise M.

    2015-01-01

    Camp scholars have designed structured curricula to engender specific outcomes and to break down the "black box" of programming. Implementation evaluation explores how well a program operates when delivered, further breaking down the black box. The purpose of this study was to explore the implementation of a new structured camp…

  19. Impact of Conflict in Syria on Syrian Children at the Zaatari Refugee Camp in Jordan

    Science.gov (United States)

    Jabbar, Sinaria Abdel; Zaza, Haidar Ibrahim

    2014-01-01

    This paper describes a study performed to investigate the impact of the conflict in Syria on Syrian refugee children. The Zaatari refugee camp in Jordan was chosen for this task. Two control (comparison) groups of children were selected: one from the Jordanian Ramtha district, which is just across the border from Syria, and that indirectly feel…

  20. Forskolin and derivatives as tools for studying the role of cAMP.

    Science.gov (United States)

    Alasbahi, R H; Melzig, M F

    2012-01-01

    Forskolin (7beta-acetoxy-1alpha,6beta,9alpha-trihydroxy-8,13-epoxy-labd-14-en-11-one) is the first main labdane diterpenoid isolated from the roots of the Indian Plectranthus barbatus ANDREWS and one of the most extensively studied constituents of this plant. The unique character of forskolin as a general direct, rapid and reversible activator of adenylyl cyclase not only underlies its wide range of pharmacological effects but also renders it as a valuable tool in the study of the role of cAMP. The purpose of this review is to provide data presenting the utility of forskolin--as a cAMP activator--for studying the function of cAMP from different biological viewpoints as follows: 1) Investigation on the role of cAMP in various cellular processes in different organs such as gastrointestinal tract, respiratory tract, reproductive organs, endocrine system, urinary system, olfactory system, nervous system, platelet aggregating system, skin, bones, eyes, and smooth muscles. 2) Studies on the role of cAMP activation and inhibition to understand the pathogenesis (e.g. thyroid autoimmune disorders, leukocyte signal transduction defect in depression, acute malaria infection, secretory dysfunction in inflammatory diseases) as well as its possibly beneficial role for curing diseases such as the regulation of coronary microvascular NO production after heart failure, the attenuation of the development or progression of fibrosis in the heart and lungs, the augmentation of myo-protective effects of ischemic preconditioning especially in the failing hearts after myocardial infarction, the stimulation of the regeneration of injured retinal ganglion cells, the curing of glaucoma and inflammatory diseases, the reducing of cyst formation early in the polycystic kidney disease, and the management of autoimmune disorders by enhancing Fas-mediated apoptosis. 3) Studies on the role of cAMP in the mechanism of actions of a number of drugs and substances such as the effect of the

  1. Communication of cAMP by connexin43 gap junctions regulates osteoblast signaling and gene expression.

    Science.gov (United States)

    Gupta, Aditi; Anderson, Hidayah; Buo, Atum M; Moorer, Megan C; Ren, Margaret; Stains, Joseph P

    2016-08-01

    Connexin43 (Cx43) containing gap junctions play an important role in bone homeostasis, yet little is known about the second messengers communicated by Cx43 among bone cells. Here, we used MC3T3-E1 pre-osteoblasts and UMR106 rat osteosarcoma cells to test the hypothesis that cAMP is a second messenger communicated by bone cells through Cx43 containing gap junctions in a manner that is sufficient to impact osteoblast function. Overexpression of Cx43 markedly enhanced the activity of a cAMP-response element driven transcriptional luciferase reporter (CRE-luc) and increased phospho-CREB and phospho-ERK1/2 levels following expression of a constitutively active Gsα or by treatment with prostaglandin E2 (PGE2), 3-Isobutyl-1-methyl xanthine (IBMX) or forskolin. The Cx43-dependent potentiation of signaling in PGE2 treated cells was not accompanied by a further increase in cAMP levels, suggesting that the cAMP was shared between cells rather than Cx43 enhancing cAMP production. To support this, we developed a novel assay in which one set of cells expressing constitutively active Gsα (donor cells) were co-cultured with a second set of cells expressing a CRE-luc reporter (acceptor cells). Using this assay, activation of a CRE-luc reporter in the acceptor cells was both Cx43- and cell contact-dependent, indicating communication of cAMP among cells. Finally, we showed that Cx43 increased the cAMP-dependent mRNA expression of receptor activator of nuclear factor kappa B ligand (RANKL) and enhanced the repression of the sclerostin mRNA, implying a potential mechanism for the modulation of tissue remodeling. In total, these data demonstrate that Cx43 can communicate cAMP between cells and, more importantly, that the communicated cAMP is sufficient to impact signal transduction cascades and the expression of key bone effector molecules between interconnected cells. PMID:27156839

  2. Lighting the Fire for 25 years: The Nature and Legacy of Astronomy Camp

    Science.gov (United States)

    McCarthy, Donald W.; Hooper, E.; Benecchi, S. D.; Henry, T. J.; Kirkpatrick, J. D.; Kulesa, C.; Oey, M. S.; Regester, J.; Schlingman, W. M.; Camp Staff, Astronomy

    2013-01-01

    In 1988, Astronomy Camp began in an era when science was entirely the realm of professionals, astronomical observatories were off-limits to the public at night, and scientists were not encouraged to spend time in science education. Since then we have grown a dynamic science education program that immerses individuals (ages 11-80), educators, schools, and Girl Scout Leaders in authentic science at Arizona’s research observatories in the Catalina mountains and at Kitt Peak. Often labeled “life changing,” these residential programs have engaged thousands of people from 49 U.S. states and 20 foreign countries. Female enrollment has increased steadily, and women now generally outnumber men in our teenage programs. Graduate students have played a major creative role and many have gone on to become educators and research leaders around the world. By involving a wide range of ages, the Camps have helped strengthen the STEM-pipeline. Many of our alumni remain in touch via social and professional networks and have developed not only into professional astronomers but also into leaders throughout society, parents, and educators. Our emphasis on age-appropriate research helped inspire today’s concepts of research-based science education and Citizen Science. An accompanying paper (E. Hooper et al.) discusses our approach to project-oriented astronomical research. Scientific discoveries include Near-Earth Objects, supernova classification, and lightcurves of Kuiper Belt Objects. The Camps have also contributed to educational research involving informal science education, youth perceptions, and student identities. Ironically, the Camps have leveraged new initiatives in both research and education at NOAO, LSST, and JWST. Here we review the philosophy, conduct, and content of Astronomy Camp and summarize the unexpected nature of its ongoing legacy. We remain grateful to The University of Arizona Alumni Association for its long-term encouragement and support.

  3. Biochemical characterization and cellular imaging of a novel, membrane permeable fluorescent cAMP analog

    Directory of Open Access Journals (Sweden)

    Zaccolo Manuela

    2008-06-01

    Full Text Available Abstract Background A novel fluorescent cAMP analog (8-[Pharos-575]- adenosine-3', 5'-cyclic monophosphate was characterized with respect to its spectral properties, its ability to bind to and activate three main isoenzymes of the cAMP-dependent protein kinase (PKA-Iα, PKA-IIα, PKA-IIβ in vitro, its stability towards phosphodiesterase and its ability to permeate into cultured eukaryotic cells using resonance energy transfer based indicators, and conventional fluorescence imaging. Results The Pharos fluorophore is characterized by a Stokes shift of 42 nm with an absorption maximum at 575 nm and the emission peaking at 617 nm. The quantum yield is 30%. Incubation of the compound to RIIα and RIIβ subunits increases the amplitude of excitation and absorption maxima significantly; no major change was observed with RIα. In vitro binding of the compound to RIα subunit and activation of the PKA-Iα holoenzyme was essentially equivalent to cAMP; RII subunits bound the fluorescent analog up to ten times less efficiently, resulting in about two times reduced apparent activation constants of the holoenzymes compared to cAMP. The cellular uptake of the fluorescent analog was investigated by cAMP indicators. It was estimated that about 7 μM of the fluorescent cAMP analog is available to the indicator after one hour of incubation and that about 600 μM of the compound had to be added to intact cells to half-maximally dissociate a PKA type IIα sensor. Conclusion The novel analog combines good membrane permeability- comparable to 8-Br-cAMP – with superior spectral properties of a modern, red-shifted fluorophore. GFP-tagged regulatory subunits of PKA and the analog co-localized. Furthermore, it is a potent, PDE-resistant activator of PKA-I and -II, suitable for in vitro applications and spatial distribution evaluations in living cells.

  4. Regulation of chloride self exchange by cAMP in cortical collecting tubule

    International Nuclear Information System (INIS)

    The hormonal control of Cl transport was examined in rabbit cortical collecting tubules using the lumen-to-bath 36Cl tracer rate coefficient (K/sub Cl/, nm/s). Tracer movement via Sl-HCO3 exchange was minimized by using HCO3-CO2-free solutions. The electrical driving force was minimized by treating with amiloride. Under these conditions, net Cl transport was zero, yet there was a large K/sub Cl/ that fell 88% on removing bath (trans) Cl. These results are consistent with the mechanism of tracer flux being predominantly Cl self exchange. K/sub Cl/ fell spontaneously with time in vitro; after this decline K/sub Cl/ could be stimulated with 8-bromo-cAMP. cAMP present from the onset of perfusion prevented the time-dependent fall in K/sub Cl/. When tracer movement was restricted to diffusion by eliminating Cl self exchange (0 Cl bath), cAMP had no effect on K/sub Cl/. Although both isoproterenol and vasopressin are known to stimulate adenylate cyclase in this epithelium, only isoproterenol mimicked the cAMP effect on K/sub Cl/. The isoproterenol effect was blocked by either propranolol or prostaglandin E2. Lumen addition of the disulfonic stilbene DIDS had no effect on K/sub Cl/. Lumen addition of furosemide or trichloromethiazide had minimal or no effect. Taken together, these results indicate that Cl self exchange is regulated by β-adrenergic agents acting via cAMP. The lack of an effect of vasopressin suggests cellular heterogeneity in this response to cAMP

  5. Mycobacterium tuberculosis cAMP Receptor Protein (Rv3676) Differs from the Escherichia coli Paradigm in Its cAMP Binding and DNA Binding Properties and Transcription Activation Properties

    OpenAIRE

    Stapleton, M.; Haq, I.; Hunt, D M; Arnvig, K. B.; Artymiuk, P. J.; Buxton, R S; Green, J

    2010-01-01

    The pathogen Mycobacterium tuberculosis produces a burst of cAMP upon infection of macrophages. Bacterial cyclic AMP receptor proteins (CRP) are transcription factors that respond to cAMP by binding at target promoters when cAMP concentrations increase. Rv3676 (CRP Mt ) is a CRP family protein that regulates expression of genes (rpfA and whiB1) that are potentially involved in M. tuberculosis persistence and/or emergence from the dormant state. Here, the CRP Mt homodimer is shown to bind two ...

  6. Changes in Socio-Emotional and Behavioral Functioning After Attending a Camp for Children with Tourette Syndrome: A Preliminary Investigation.

    Science.gov (United States)

    Eaton, Cyd K; LaMotte, Julia; Gutierrez-Colina, Ana M; Kardon, Patricia; Blount, Ronald L

    2016-08-01

    Children and adolescents with Tourette syndrome are at risk for social, emotional, and behavioral difficulties that may negatively influence feelings of self-competence and attitudes toward having this diagnosis. Attending a camp for children with Tourette syndrome may facilitate improvements in overall socio-emotional and behavioral functioning and self-perception. The current study obtained data from 37 campers (76 % male, 24 % female) and 47 caregivers of campers to investigate changes in children's emotional and behavioral functioning, self-perception (i.e., social and general), attitudes towards having Tourette syndrome, and how different they felt from peers after attending a 1-week summer camp for youth with Tourette syndrome using a pre-post design. Results indicated that campers endorsed a significantly improved sense of social self-competence and more favorable attitudes toward having Tourette syndrome post-camp. Campers also tended to endorse feeling less different than peers at camp versus peers in general. Caregivers endorsed significantly less severe symptoms associated with Tourette syndrome for campers after attending camp. No pre-to-post-camp changes were observed for campers' levels of anxiety or obsessive-compulsive symptoms. These preliminary findings suggest that attending camp or having other opportunities to interact with similar peers may promote better perceptions of social self-competence, more favorable attitudes toward having Tourette syndrome, and a stronger sense of affiliation with peers for children with Tourette syndrome. PMID:26589437

  7. RU SciTech: Weaving Astronomy and Physics into a University-sponsored Summer Camp for Middle School Students

    Science.gov (United States)

    Hart, Quyen N.

    2015-01-01

    We present a successful model for organizing a small University-sponsored summer camp that integrates astronomy and physics content with other science disciplines and computer programming content. The aim of our science and technology camp is to engage middle school students in a wide array of critical thinking tasks and hands-on activities centered on science and technology. Additionally, our program seeks to increase and maintain STEM interest among children, particularly in under-represented populations (e.g., Hispanic, African-American, women, and lower socioeconomic individuals) with hopes of decreasing disparities in diversity across many STEM fields.During this four-day camp, organized and facilitated by faculty volunteers, activities rotated through many STEM modules, including optics, telescopes, circuit building, computer hardware, and programming. Specifically, we scaffold camp activities to build upon similar ideas and content if possible. Using knowledge and skills gained through the AAS Astronomy Ambassadors program, we were able to integrate several astronomy activities into the camp, leading students through engaging activities, and conduct educational research. We present best practices on piloting a similar program in a university environment, our efforts to connect the learning outcomes common across all the modules, specifically in astronomy and physics, outline future camp activities, and the survey results on the impact of camp activities on attitudes toward science, technology, and science careers.

  8. Prison Camp No. 29 for Prisoners of War from the Second World War on the Territory of Kazakhstan between 1943–1949

    OpenAIRE

    Aimar Ventsel; Baurzhan Zhanguttin

    2016-01-01

    This article is the first publication of materials about Pakhta-Aral prison camp No. 29 for prisoners of war. The fate of prisoners of war (both Western and Eastern) remains largely unclear. One reason is because the camps for prisoners of war were subordinated to an extremely closed and classified structure – the GUPVI. To some extent, Pakhta-Aral was an untypical prison camp in the Soviet prison camp system. While most prison camps were established to support industry or resource extraction...

  9. gidakiimanaaniwigamig (gidaa) science camps for 3-12 students at Fond du Lac Band of Lake Superior Chippewa

    Science.gov (United States)

    Ito, E.; Kowalczak, C.; Dalbotten, D. M.; Pellerin, H.; Greensky, L.

    2015-12-01

    Gidaa informal science camps have been held in various formats and emphases for over 10 years at Fond du Lac (FDL). These camps provided a safe place for young people to be "nerds" but did not have specific focus. In the last 5 years the camp themes became more focused on environmental issues facing the reservation. From 2009 to 2014 the camps focused on issues surrounding the health of wild rice plants. Since September 2014, we are focusing on climate literacy and how climate changes are affecting tribal environment. We learned from our wild rice themed activities that students are more focused and interested in topics that affect them and their reservation and traditional activities.Each camp has a presentation by a staff from the FDL Resource Management Division. These presentations are sometimes given on Friday evenings after dinner and yet students remain alert, respectful, and actively take notes. The presentation topic is known in advance and camp teachers (local middle and high school teachers who have been with us for 5 to 10 years) plan lessons around that topic. In addition, college students, some of them past camp participants, are on hand to assist the teachers and to provide role models. Students have investigated, for example, possible effects of climate change on the timing of rising of sugar maple sap and whether sugar maple tress will continue to thrive in their area, efforts to bring back sturgeon to local rivers and how the changes in water temperature may affect that effort, possible climate connection to decline of moose and walleye pike population at 5 weekend camps during the last academic year. We have conducted 2 surveys by an outside evaluator and will have the results before the next round of camps starts in fall 2015 to help us tweak the format if necessary. Teachers and planners (PIs) are happy with the way camps are running this year; there is a good balance of camp activities that allow teachers to translate and adapt the

  10. Transcriptome changes and cAMP oscillations in an archaeal cell cycle

    Directory of Open Access Journals (Sweden)

    Soppa Jörg

    2007-06-01

    Full Text Available Abstract Background The cell cycle of all organisms includes mass increase by a factor of two, replication of the genetic material, segregation of the genome to different parts of the cell, and cell division into two daughter cells. It is tightly regulated and typically includes cell cycle-specific oscillations of the levels of transcripts, proteins, protein modifications, and signaling molecules. Until now cell cycle-specific transcriptome changes have been described for four eukaryotic species ranging from yeast to human, but only for two prokaryotic species. Similarly, oscillations of small signaling molecules have been identified in very few eukaryotic species, but not in any prokaryote. Results A synchronization procedure for the archaeon Halobacterium salinarum was optimized, so that nearly 100% of all cells divide in a time interval that is 1/4th of the generation time of exponentially growing cells. The method was used to characterize cell cycle-dependent transcriptome changes using a genome-wide DNA microarray. The transcript levels of 87 genes were found to be cell cycle-regulated, corresponding to 3% of all genes. They could be clustered into seven groups with different transcript level profiles. Cluster-specific sequence motifs were detected around the start of the genes that are predicted to be involved in cell cycle-specific transcriptional regulation. Notably, many cell cycle genes that have oscillating transcript levels in eukaryotes are not regulated on the transcriptional level in H. salinarum. Synchronized cultures were also used to identify putative small signaling molecules. H. salinarum was found to contain a basal cAMP concentration of 200 μM, considerably higher than that of yeast. The cAMP concentration is shortly induced directly prior to and after cell division, and thus cAMP probably is an important signal for cell cycle progression. Conclusion The analysis of cell cycle-specific transcriptome changes of H. salinarum

  11. A tool for modernisation? The Boer concentration camps of the South African War, 1900–1902

    Directory of Open Access Journals (Sweden)

    Elizabeth van Heyningen

    2010-05-01

    Full Text Available While not denying the tragedy of the high mortality of people in the concentration camps in the South African War of 1899–1902, this article suggests that, for Lord Milner and the British Colonial Office, the camps became a means of introducing the rural society of the Boers to the facilities of modern life. To some extent they became, in effect, part of Milner’s project for ‘civilising’ and assimilating the Boers into British colonial society. The high mortality rate was finally contained through the introduction of a modern public health system, including the use of statistics and the employment of qualified doctors and nurses. Young Boer women working in the camp hospitals as nurse aids were trained as ‘probationers’ and classes in infant and child care were offered to the Boer mothers. In addition, the need for adequate water supplies and effective sanitation meant that an infrastructure was established in the camps that familiarised the Boers with modern sanitary routines and left a legacy of more substantial services for the Transvaal and Orange Free State villages.

    Author comment: My article was never intended to denigrate Afrikaners in any way. The republican Boers were caught up in an unjust war and they suffered dreadful losses as a result. However, I have argued elsewhere that many of the farm families, who had had little contact with modern preventive medicine, functioned within a different cultural world from the British who ran the camps. I have discussed this in much more detail in the following article: Van Heyningen E. Women and disease. The clash of medical cultures in the concentration camps of the South African War. In: Cuthbertson G, Grundlingh A, Suttie M-L, editors. Writing a wider war. Rethinking gender, race, and identity in the South African War, 1899–1902. Athens: Ohio University Press, 2002; p. 186–212. A shorter version of the article has also been published in Van Heyningen E

  12. Digital Geologic Map of the American Camp Unit and vicinity, Washington (NPS, GRD, GRE, SAJH, SJIS digital map)

    Data.gov (United States)

    National Park Service, Department of the Interior — The Digital Geologic Map of the American Camp Unit and vicinity, Washington is composed of GIS data layers complete with ArcMap 9.2 layer (.LYR) files, two...

  13. High adenylyl cyclase activity and in vivo cAMP fluctuations in corals suggest central physiological role.

    Science.gov (United States)

    Barott, K L; Helman, Y; Haramaty, L; Barron, M E; Hess, K C; Buck, J; Levin, L R; Tresguerres, M

    2013-01-01

    Corals are an ecologically and evolutionarily significant group, providing the framework for coral reef biodiversity while representing one of the most basal of metazoan phyla. However, little is known about fundamental signaling pathways in corals. Here we investigate the dynamics of cAMP, a conserved signaling molecule that can regulate virtually every physiological process. Bioinformatics revealed corals have both transmembrane and soluble adenylyl cyclases (AC). Endogenous cAMP levels in live corals followed a potential diel cycle, as they were higher during the day compared to the middle of the night. Coral homogenates exhibited some of the highest cAMP production rates ever to be recorded in any organism; this activity was inhibited by calcium ions and stimulated by bicarbonate. In contrast, zooxanthellae or mucus had >1000-fold lower AC activity. These results suggest that cAMP is an important regulator of coral physiology, especially in response to light, acid/base disturbances and inorganic carbon levels. PMID:23459251

  14. Twitching motility and cAMP levels: signal transduction through a single methyl-accepting chemotaxis protein.

    Science.gov (United States)

    Jansari, Vibhuti H; Potharla, Vishwakanth Y; Riddell, Geoff T; Bardy, Sonia L

    2016-06-01

    The Pseudomonas aeruginosa Chp chemosensory system regulates twitching motility, intracellular adenosine 3('') 5(')-cyclic monophosphate (cAMP) levels and is postulated to be involved in directional twitching towards phosphatidylethanolamine (PE). Because PilJ is the only methyl-accepting chemotaxis protein (MCP) identified in the Chp system, we determined the role of PilJ in mediating signal transduction for the distinct outputs of this system. Mutants that lack the periplasmic domain of PilJ (pilJΔ74-273) showed lower levels of cAMP but retained directional twitching towards PE. While initial studies revealed reduced twitching motility by PilJΔ74-273, this was due to decreased cAMP levels. Our data illustrate the importance of the periplasmic domain of PilJ in regulating cAMP. This is the first time a defined domain within PilJ has been identified as having a distinct role in signal transduction. PMID:27190147

  15. Final Report Recommended Actions to Reduce Electrical Peak Loads at the Marine Corps Air Station at Camp Pendleton, California

    Energy Technology Data Exchange (ETDEWEB)

    Hail, John C.; Brown, Daryl R.; McCullough, Jeffrey J.; Underhill, Ronald M.

    2001-05-08

    PNNL conducted a walk-through audit of Marine Corps Air Station at Camp Pendleton. The audit inspected a significant portion of the site and identified a large number of similar energy saving opportunities across all building types.

  16. The Trumpeter, Company 424 Civilian Conservation Corps Camp Redington in Swan Quarter, North Carolina; October Issue, Volume 1

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is a historic monthly report of Camp Redington Civilian Conservation Corps located in Swan Quarter, North Carolina. It describes the progress and...

  17. [Encapsulated voices : Estonian sound recordings from the German prisoner-of-war camps in 1916-1918] / Tõnu Tannberg

    Index Scriptorium Estoniae

    Tannberg, Tõnu, 1961-

    2013-01-01

    Arvustus: Encapsulated voices : Estonian sound recordings from the German prisoner-of-war camps in 1916-1918 (Das Baltikum in Geschichte und Gegenwart, 5). Hrsg. von Jaan Ross. Böhlau Verlag. Köln, Weimar und Wien 2012

  18. Narratives from Jenin Refugee Camp: Children as extreme defence against the disintegration of family and community

    Directory of Open Access Journals (Sweden)

    Guido Veronese

    2010-07-01

    Full Text Available This paper aim to explore practices that create serious risks to the physical and psychological  health of Palestinian children. The typical stories of three children interviewed at Jenin Refugee Camp are subjected to content analysis. This analysis also extends to the micro and macro social developmental context of these children (which the share with the entire population of the camp. Key themes emerging from the analysis include the need to "redeem" grand parents and parents (depressed, preoccupied, without hope, intolerance of imprisonment and being coerced into confined spaces, which are invaded on daily bases, the need to spaces to play in, the acceleration, through violence, toward adulthood. The motivations leading to dangerous practices and risk and protective factors are discussed.

  19. Narratives from Jenin Refugee Camp: Children as extreme defence against the disintegration of family and community

    Directory of Open Access Journals (Sweden)

    Guido Veronese

    2010-07-01

    Full Text Available This paper aim to explore practices that create serious risks to the physical and psychological health of Palestinian children. The typical stories of three children interviewed at Jenin Refugee Camp are subjected to content analysis. This analysis also extends to the micro and macro social developmental context of these children (which the share with the entire population of the camp. Key themes emerging from the analysis include the need to "redeem" grand parents and parents (depressed, preoccupied, without hope, intolerance of imprisonment and being coerced into confined spaces, which are invaded on daily bases, the need to spaces to play in, the acceleration, through violence, toward adulthood. The motivations leading to dangerous practices and risk and protective factors are discussed.

  20. Norovirus outbreak at a wildland fire base camp ignites investigation of restaurant inspection policies.

    Science.gov (United States)

    Britton, Carla L; Guzzle, Patrick L; Hahn, Christine G; Carter, Kris K

    2014-01-01

    Norovirus outbreaks occur worldwide and have been associated with congregate settings (e.g., military and recreational camps). Investigation of a norovirus outbreak at a wildland fire base camp identified 49 (27%) illnesses among approximately 180 responders. Epidemiologic evidence implicated a restaurant as the infection source. Eight (89%) of nine wildland fire responder groups who ate at the restaurant had ill members; no groups who ate elsewhere reported ill members. An environmental health specialist restaurant inspection identified lack of managerial knowledge to protect against foodborne disease one year after the restaurant's opening; earlier inspection after opening might have led to earlier intervention. States were surveyed to determine existence of any policy or rule for food establishment inspection after opening and inspection timing. Among 18 states, five had no state rule or policy; nine had a policy in place; and four required postopening inspection by rule. Further research is needed to evaluate post-opening inspection efficacy and timing. PMID:25185322

  1. Aggression Among Male Migrant Farmworkers Living in Camps in Eastern North Carolina.

    Science.gov (United States)

    Kraemer Diaz, Anne E; Weir, Maria M; Isom, Scott; Quandt, Sara A; Chen, Haiying; Arcury, Thomas A

    2016-06-01

    The living and working arrangements of migrant farmworkers in North Carolina are shaped by grower provided housing, codified by the US Department of Labor's H-2A temporary worker program. Growers typically dictate all facets about residences, living conditions, and even food acquirements. Farmworker camps likely contribute to aggression because of the forced relationships among a small group of people that live, work and recreate together for extended time periods. Participants in the study consisted of 371 farmworkers living in 183 camps. The Revised Conflict Tactics Scale was used to assess aggression among migrant farmworkers. Results indicated that aggressive acts were prevalent among the farmworkers, but the frequency of aggressive acts was low. The most common aggressive act was minor psychological aggression. Results also indicated that alcohol misuse was a common characteristic for both victims and perpetrators and the majority of aggressive acts occurred later in the agricultural season. PMID:26022146

  2. H.E. Mr Josep Piqué i Camps, Minister of Science and Technology, Spain

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Photo 01: H.E. Mr Josep Piqué i Camps, Minister for Science and Technology, Spain (right foreground) visiting SM 18 with (from left to right) F. Rodriguez Mateos, G. Babé, C. Dopazo in front of H.E. Mr J. Pérez-Villanueva y Tovar, Ambassador. Photo 05: The delegation, accompanied by Spanish scientists at CERN, also visited the LHC superconducting magnet test hall. From l. to r.: Matteo Cavalli-Sforza of CERN, Josep Piqué i Camps, Spanish Minister of Science and Technology, César Dopazo, Director-General of CIEMAT (Spanish Research Centre for Energy, Environment and Technology), Juan Antonio Rubio, ETT Division Leader at CERN, Manuel Aguilar-Benitez, Spanish Delegate to Council, Gonzalo León, Secretary-General of Scientific Policy to the Minister, and Manuel Delfino, IT Division Leader at CERN.

  3. Entre camping et campement, visible et invisible, deux vies pour l’habitat de plein air

    OpenAIRE

    Poulain, France

    2016-01-01

    En France, tente, caravane, mobil-home ou camping-car sont perçus depuis plus de cinquante ans comme des habitats de loisirs. Nul autre usage ne peut réglementairement en être fait. D’ailleurs, plusieurs millions de Français les utilisent tout au long de l’année pour profiter de leurs périodes de temps libre sur parcelles privées ou à l’intérieur des terrains de camping autorisés. Mais le loisir est-il le seul usage de ces habitats ? Ne peuvent-ils pas servir à autre chose ? Et ces autres usa...

  4. Zoran Mušič and the Problem of Concentration Camp Art

    Directory of Open Access Journals (Sweden)

    Asta Vrečko

    2014-07-01

    Full Text Available Art that concerns itself with themes of concentration camps, the Holocaust and genocide is extremely varied. Many authors of different generations have been engaged in it in different media. And yet, similar problems and dilemmas appear in the analysis of this art. Often questions about the artistic merit of the works are secondary, being overshadows by questions about the moral justification of the existence of the work of art and its historical accuracy. Reflections on the aesthetics of these works of art turn out to be very delicate. The cycle We Are not the Last by Zoran Mušič (1909–2005, one of the most recognisable Slovene painters, is distinguished at once by aesthetic perfection and the immediate cruel reality of the imagery. Reflecting upon his works within the framework of concentration camp art and survivor‘s testimony can contribute to a better understanding of his works.

  5. Carbon-14 production compared to oxygen isotope records from Camp Century, Greenland and Devon Island, Canada

    International Nuclear Information System (INIS)

    Carbon-14 production rate variations that are not explainable by geomagnetic changes are thought to be in antiphase with solar activity and as such should be in antiphase with paleotemperature records or proxy temperature histories such as those obtainable from oxygen isotope analyses of ice cores. Oxygen isotope records from Camp Century, Greeland and Devon Island Ice Cap are in phase with each other over thousands of years and in antiphase to the 14C production rate residuals. (Auth.)

  6. Sudanese and South Sudanese refugee women’s sense of security in Kakuma refugee camp.

    OpenAIRE

    Nilsson, Helena Marianne

    2013-01-01

    This thesis aims to find out how Sudanese and South Sudanese refugee women experience their security and safety in Kakuma refugee camp, which is situated in north- western part of Kenya. Sudan and South Sudan has had two civil wars since its independence from the British colonialism. The civil wars in Sudan and South Sudan have mainly been concerning the differences between northern and southern Sudan, with the northern part predominantly Muslim and the southern is predominantly Christian. Th...

  7. Eating behaviors, victimization, and desire for supportive intervention among adolescents in weight-loss camps.

    Science.gov (United States)

    King, Kelly M; Puhl, Rebecca M; Luedicke, Joerg; Peterson, Jamie Lee

    2013-12-01

    This study examined links between eating behaviors, weight-based victimization (WBV) and preferences for bullying intervention among adolescents. Adolescents enrolled in weight loss camps participated in an online survey (N = 361). Regression models examined relationships between key variables. Almost half of adolescents who experienced WBV engaged in unhealthy eating behaviors, which corresponded to less desire for supportive intervention. Unhealthy eating behaviors may offset adaptive coping strategies to deal with WBV, such as support from peers and family. PMID:24183141

  8. Soap is not enough: handwashing practices and knowledge in refugee camps, Maban County, South Sudan

    OpenAIRE

    Phillips, Raina M; Vujcic, Jelena; Boscoe, Andrew; Handzel, Thomas; Aninyasi, Mark; Cookson, Susan T.; Blanton, Curtis; S Blum, Lauren; Ram, Pavani K.

    2015-01-01

    Background Refugees are at high risk for communicable diseases due to overcrowding and poor water, sanitation, and hygiene conditions. Handwashing with soap removes pathogens from hands and reduces disease risk. A hepatitis E outbreak in the refugee camps of Maban County, South Sudan in 2012 prompted increased hygiene promotion and improved provision of soap, handwashing stations, and latrines. We conducted a study 1 year after the outbreak to assess the knowledge, attitudes, and practices of...

  9. FimL regulates cAMP synthesis in Pseudomonas aeruginosa.

    Directory of Open Access Journals (Sweden)

    Yuki F Inclan

    Full Text Available Pseudomonas aeruginosa, a ubiquitous bacteria found in diverse ecological niches, is an important cause of acute infections in immunocompromised individuals and chronic infections in patients with Cystic Fibrosis. One signaling molecule required for the coordinate regulation of virulence factors associated with acute infections is 3', 5'-cyclic adenosine monophosphate, (cAMP, which binds to and activates a catabolite repressor homolog, Vfr. Vfr controls the transcription of many virulence factors, including those associated with Type IV pili (TFP, the Type III secretion system (T3SS, the Type II secretion system, flagellar-mediated motility, and quorum sensing systems. We previously identified FimL, a protein with histidine phosphotransfer-like domains, as a regulator of Vfr-dependent processes, including TFP-dependent motility and T3SS function. In this study, we carried out genetic and physiologic studies to further define the mechanism of action of FimL. Through a genetic screen designed to identify suppressors of FimL, we found a putative cAMP-specific phosphodiesterase (CpdA, suggesting that FimL regulates cAMP levels. Inactivation of CpdA increases cAMP levels and restores TFP-dependent motility and T3SS function to fimL mutants, consistent with in vivo phosphodiesterase activity. By constructing combinations of double and triple mutants in the two adenylate cyclase genes (cyaA and cyaB, fimL, and cpdA, we show that ΔfimL mutants resemble ΔcyaB mutants in TM defects, decreased T3SS transcription, and decreased cAMP levels. Similar to some of the virulence factors that they regulate, we demonstrate that CyaB and FimL are polarly localized. These results reveal new complexities in the regulation of diverse virulence pathways associated with acute P. aeruginosa infections.

  10. Calmness in mindful practice: emotional stroop performance following stress induction in a mindfulness camp

    OpenAIRE

    Yeung, Kin-yan.; 楊健恩.

    2012-01-01

    The current study aims to explore the underlying mechanisms of mindfulness in understanding how it can bring about beneficial effects in clinical applications. We adopted a prospective design to examine the impact of a 3-day intensive mindfulness training camp on responses to different categories of words on the Emotional Stroop task (Watts, McKenna, Sharrock, & Trezise, 1986) and compared the performance of this group of participants with that of a control group. Five Facets of Mindfulness...

  11. Abanicos aluviales cuaternarios del Baix Camp (provincia de Tarragona): resultados de dataciones radiométricas

    OpenAIRE

    Villamarín, J. A.; Masana, E; Calderón, T.; Julià, Ramón; Santanach, P.

    1998-01-01

    The Quaternary fans which cover the southernmost part of the El Camp Basin belong to three generations. Noticeable calcrete levels developed on the top of fans from the first and second generation. Radiometric dating by means of U/Th and termolumiscence techniques of the mentioned caliche levels allow us to attribute a minimal age of ca. 300000 years to the top of the first generation fans, and ca. 100000 years to the top of the second generation alluvial fans

  12. Giardiasis in children living in post-earthquake camps from Armenia (Colombia)

    OpenAIRE

    Gonzalez Maria; Torres Elizabeth; Gallego Martha; Loango Nelsy; Marin-Vasquez Carolina; Lora-Suarez Fabiana; Castaño-Osorio Jhon; Gómez-Marín Jorge

    2002-01-01

    Abstract Background An earthquake in the coffee growing region of Colombia on January 25, 1999 destroyed 70% of the houses in Armenia city. Transitory housing camps still remained until two years after the disaster. Parasitological studies found that, in this population, giardiasis was the most frequent parasitic infection. This study was carried out in order to determine the epidemiological risk factors associated with this high prevalence. Methods Fecal samples were obtained from 217 childr...

  13. Retinoic acid and cAMP inhibit rat hepatocellular carcinoma cell proliferation and enhance cell differentiation

    International Nuclear Information System (INIS)

    Hepatocellular carcinoma (HCC) is the third highest cause of cancer death worldwide. In general, the disease is diagnosed at an advanced stage when potentially curative therapies are no longer feasible. For this reason, it is very important to develop new therapeutic approaches. Retinoic acid (RA) is a natural derivative of vitamin A that regulates important biological processes including cell proliferation and differentiation. In vitro studies have shown that RA is effective in inhibiting growth of HCC cells; however, responsiveness to treatment varies among different HCC cell lines. The objective of the present study was to determine if the combined use of RA (0.1 µM) and cAMP (1 mM), an important second messenger, improves the responsiveness of HCC cells to RA treatment. We evaluated the proliferative behavior of an HCC cell line (HTC) and the expression profile of genes related to cancer signaling pathway (ERK and GSK-3β) and liver differentiation [E-cadherin, connexin 26 (Cx26), and connexin 32 (Cx32)]. RA and cAMP were effective in inhibiting the proliferation of HTC cells independently of combined use. However, when a mixture of RA and cAMP was used, the signals concerning the degree of cell differentiation were increased. As demonstrated by Western blot, the treatment increased E-cadherin, Cx26, Cx32 and Ser9-GSK-3β (inactive form) expression while the expression of Cx43, Tyr216-GSK-3β (active form) and phosphorylated ERK decreased. Furthermore, telomerase activity was inhibited along treatment. Taken together, the results showed that the combined use of RA and cAMP is more effective in inducing differentiation of HTC cells

  14. Retinoic acid and cAMP inhibit rat hepatocellular carcinoma cell proliferation and enhance cell differentiation

    Energy Technology Data Exchange (ETDEWEB)

    Ionta, M. [Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Alfenas MG (Brazil); Departamento de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo SP (Brazil); Rosa, M.C.; Almeida, R.B.; Freitas, V.M.; Rezende-Teixeira, P.; Machado-Santelli, G.M. [Departamento de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo SP (Brazil)

    2012-05-25

    Hepatocellular carcinoma (HCC) is the third highest cause of cancer death worldwide. In general, the disease is diagnosed at an advanced stage when potentially curative therapies are no longer feasible. For this reason, it is very important to develop new therapeutic approaches. Retinoic acid (RA) is a natural derivative of vitamin A that regulates important biological processes including cell proliferation and differentiation. In vitro studies have shown that RA is effective in inhibiting growth of HCC cells; however, responsiveness to treatment varies among different HCC cell lines. The objective of the present study was to determine if the combined use of RA (0.1 µM) and cAMP (1 mM), an important second messenger, improves the responsiveness of HCC cells to RA treatment. We evaluated the proliferative behavior of an HCC cell line (HTC) and the expression profile of genes related to cancer signaling pathway (ERK and GSK-3β) and liver differentiation [E-cadherin, connexin 26 (Cx26), and connexin 32 (Cx32)]. RA and cAMP were effective in inhibiting the proliferation of HTC cells independently of combined use. However, when a mixture of RA and cAMP was used, the signals concerning the degree of cell differentiation were increased. As demonstrated by Western blot, the treatment increased E-cadherin, Cx26, Cx32 and Ser9-GSK-3β (inactive form) expression while the expression of Cx43, Tyr216-GSK-3β (active form) and phosphorylated ERK decreased. Furthermore, telomerase activity was inhibited along treatment. Taken together, the results showed that the combined use of RA and cAMP is more effective in inducing differentiation of HTC cells.

  15. Trading Effort for Freedom: Workday Credits in the Stalinist Camp System1

    OpenAIRE

    Simon Ertz

    2005-01-01

    In this paper, we focus on the economics of forced labour during Stalinism. We show that, despite the regime's ability to apply massive coercion, the camp system administrators used various incentives to raise labour productivity. The particular incentive system examined in this paper is the so-called workday credit system. Workday credits provided for a reduction in sentences for plan fulfilment and overfulfilment to motivate prisoners. An analysis of the economic implications of this instru...

  16. Mapping of landslide susceptibility of coastal cliffs : the Mont-Roig del Camp case study

    OpenAIRE

    Montoya-Montei, I.; Rodríguez-Santalla, I.; Sánchez-García, M.J.; Alcántara-Carrió, Javier; Martín-Velázquez, S.; Gómez-Ortiz, D.; Martín-Crespo, T.

    2012-01-01

    The weathered and fractured conglomerate cliffs of Mont Roig del Camp constitute a rock fall hazard for the surrounding pocket beaches and, therefore, for the population that frequent them, especially over the summer. Landslide susceptibility of the cliff has been assessed using the Rock Engineering System method (RES). The determinant and triggering factors considered in this study include: wave exposure, shoreline variations, cliff height, cliff slope, geotechnical quality of the rocky mass...

  17. Transcriptional regulation induced by cAMP elevation in mouse Schwann cells

    OpenAIRE

    Schmid, Daniela; Zeis, Thomas; Schaeren-Wiemers, Nicole

    2014-01-01

    In peripheral nerves, Schwann cell development is regulated by a variety of signals. Some of the aspects of Schwann cell differentiation can be reproduced in vitro in response to forskolin, an adenylyl cyclase activator elevating intracellular cAMP levels. Herein, the effect of forskolin treatment was investigated by a comprehensive genome-wide expression study on primary mouse Schwann cell cultures. Additional to myelin-related genes, many so far unconsidered genes were ascertained to be mod...

  18. Professional burnout of personnel working in summer camps of people with disabilities

    OpenAIRE

    Giannia N.; Kokaridas D.; Ampatzidou A.; Paslamouska M.; Patsiaouras A.; Latini E.; Kyparisi G.

    2011-01-01

    Introduction: Professional burnout constitutes a syndrome of physical and mental exhaustion occurring in working environment with symptoms that are present after frequent and long-term exposure in difficult working conditions especially in special education settings where a higher burnout in noticed due to tne nature of the profession. Purpose: The purpose of this study was to examine professional burnout of working personnel in summer camps for people with disabilities. Materials – Methods: ...

  19. Reaching the unreached: Mobile surgical camps in a remote village of Himachal Pradesh

    Directory of Open Access Journals (Sweden)

    Sonal Bathla

    2014-01-01

    Conclusion: Uterovaginal prolapse is not only socially embarrassing and disabling; its surgical treatment is complex and costly too. The free mobile surgical camps under "Project Prolapse" in Shillai, Himachal Pradesh has provided relief to old neglected, disabled women suffering from prolapse in this remote village. Parallel counseling of women and dais for safe hospital delivery and training subordinates in prolapse surgery may help in addressing the problem of POP in this area in the long run.

  20. Five days at outdoor education camp without screens improves preteen skills with nonverbal emotion cues

    OpenAIRE

    Uhls, YT; Michikyan, M; Morris, J; Garcia, D; Small, GW; Zgourou, E; Greenfield, PM

    2014-01-01

    A field experiment examined whether increasing opportunities for face-to-face interaction while eliminating the use of screen-based media and communication tools improved nonverbal emotion-cue recognition in preteens. Fifty-one preteens spent five days at an overnight nature camp where television, computers and mobile phones were not allowed; this group was compared with school-based matched controls (n = 54) that retained usual media practices. Both groups took pre- and post-tests that requi...

  1. Access to Safe Water and Personal Hygiene Practices in the Kulandia Refugee Camp (Jerusalem)

    OpenAIRE

    Mohamad Issa; Michael McHenry; Abdul Aziz Issa; R. Alexander Blackwood

    2015-01-01

    Diarrheal illness, frequently associated with fecal-oral transmission, is one of the leading causes of death worldwide. It is commonly preventable through the implementation of safe water practices. This experiment concerns how to best implement safe water practices in a quasi-permanent refugee camp setting with limited ability for structural changes. Specifically, we explore how health promotion activities that help identify target groups for hygiene interventions can play a role in disease ...

  2. Evaluation of a short-term medical mission to Syrian refugee camps in Turkey

    OpenAIRE

    Alghothani, Nora; Alghothani, Yousef; Atassi, Bassel

    2012-01-01

    BACKGROUND: The escalating political and humanitarian crisis in Syria has left thousands detained, killed or displaced in neighboring countries. Given the permission and co-operation of the Turkish health authorities, a short-term medical mission to the Syrian refugee camps in the Hatay province was arranged. MATERIALS AND METHODS: To assess this mission's impact and potential expansion to serve other more emergently inflicted areas both inside and outside the Syrian borders, an evaluation wa...

  3. Zoran Mušič and the Problem of Concentration Camp Art

    OpenAIRE

    Asta Vrečko

    2014-01-01

    Art that concerns itself with themes of concentration camps, the Holocaust and genocide is extremely varied. Many authors of different generations have been engaged in it in different media. And yet, similar problems and dilemmas appear in the analysis of this art. Often questions about the artistic merit of the works are secondary, being overshadows by questions about the moral justification of the existence of the work of art and its historical accuracy. Reflections on the aesthetics of the...

  4. Hope and recognition. A music project among youth in a Palestinian refugee camp

    OpenAIRE

    Vegard Storsve; Inger Anne Westbye; Even Ruud

    2012-01-01

    Hope and recognition are keywords that characterize the cultural and humanitarian aid The Norwegian Academy of Music together with NORWAC2 and Forum for Culture and International Cooperation are doing in South-Lebanon. Since 2002, Norwegian music educator Vegar Storsve together with Petter Barg and Inger Anne Westby have conducted a music project in the Palestinian refugee camp Rashedie and in a Lebanese special school in the city of Tyr. They have organized a community music project for heal...

  5. Agents of Human Anaplasmosis and Lyme Disease at Camp Ripley, Minnesota

    OpenAIRE

    Johnson, Russell C.; Kodner, Carrie; Jarnefeld, Janet; Eck, Deborah K.; Xu, Yaning

    2011-01-01

    The transmission dynamics of Anaplasma phagocytophilum (Ap) and Borrelia burgdorferi (Bb) among Ixodes scapularis (Is) and mammalian hosts was investigated at Camp Ripley, an area representative of central Minnesota. Prevalence of white-footed mouse infection with Ap and Bb were 20% and 42%, respectively, with a coinfection level of 14%. Peak levels of infection with both agents occurred in May. The average levels of seropositivity to Ap and Bb were 29.3% and 48%, respectively. Of the mice in...

  6. Cross-Talk between Signaling Pathways Can Generate Robust Oscillations in Calcium and cAMP

    OpenAIRE

    Siso-Nadal, Fernando; Fox, Jeffrey J.; Laporte, Stéphane A.; Hébert, Terence E.; Swain, Peter S

    2009-01-01

    Background To control and manipulate cellular signaling, we need to understand cellular strategies for information transfer, integration, and decision-making. A key feature of signal transduction is the generation of only a few intracellular messengers by many extracellular stimuli. Methodology/Principal Findings Here we model molecular cross-talk between two classic second messengers, cyclic AMP (cAMP) and calcium, and show that the dynamical complexity of the response of both messengers inc...

  7. Evaluation of the NOAA CAREERS Weather Camp's Effectiveness in Promoting Atmospheric Science amongst High School Students

    Science.gov (United States)

    Olgin, J. G.; Fitzgerald, R. M.; Morris, V. R.

    2013-12-01

    The NOAA Center for Atmospheric Science (NCAS) sponsors the Channeling Atmospheric Research into Educational Experiences Reaching Students program (CAREERS); a program that manages a network of weather camps for students in secondary education with particular focus on increasing access for students from traditionally underrepresented backgrounds. Hosted by a college or university, the primary mission goals of the program are to engage students in discussions, lectures and interactive projects to better learn and comprehend a suite of atmospheric science disciplines (i.e. weather forecasting, environmental modeling, atmospheric data acquisition), and guide talented students towards higher education to pursue careers in atmospheric science primarily, or toward other STEM field professions. The need to evaluate and analyze the program's efficacy is crucial for continued growth and sustainability. Therefore a means to identify and measure the success of the program's initiatives will be addressed. Two Hispanic serving institutions, the University of Texas at El Paso (UTEP) and the University of Puerto Rico in Mayaguez (UPRM), both hosted the CAREER weather camps during the summers of 2012 and 2013, and provide the basis of this initial analysis. Participants performed entrance surveys of their knowledge of atmospheric science prior to the course. They were then re-evaluated through exit surveys over the topics covered during the weather camp. These data will be analyzed to correlate which program activities worked best in increasing participant awareness (i.e. geology tours of the local area, discussion on local climate variations, geophysical and geochemical demonstrations), and comprehension of atmospheric science. A comparison between the two universities on their uniqueness in program design and execution will also highlight those activities that best progressed CAREERS' program goals. Results from this analysis, along with possible new strategies for improved

  8. Quality of life of Syrian refugees living in camps in the Kurdistan Region of Iraq

    OpenAIRE

    Aziz, Izaddin A.; Hutchinson, Claire V.; Maltby, John

    2014-01-01

    The current study explores the perceived quality of life of Syrian refugees who have entered the Kurdistan Region of Iraq. Two hundred and seventy participants residing in refugee camps in the Erbil region in Kurdistan completed the WHOQOL-BREF, which measures Quality of Life (QOL) within four domains; physical, psychological, social relationships and environment. Syrian refugees in Kurdistan scored significantly lower for general population norms on physical health, psychological and environ...

  9. Assessment of pollution risk ascribed to Santa Margarida Military Camp activities (Portugal)

    OpenAIRE

    M.J. Matias; Marques, J M; Figueiredo, P.; M.J. Basto; M.M. Abreu; Carreira, P.M.; C. Ribeiro; Flambó, A.; J. Feliciano; Vicente, E.M.

    2009-01-01

    Santa Margarida Military Camp (S.M.M.C.) is the only one Portuguese military training area, including firing ranges for tactical military manoeuvres of mechanised divisions. For this reason, various negative effects on the environment were expected due to the military activities, as the Military Camp’s area is classified as a high vulnerability area to pollution of its multilayer porous aquifers. The aim of this study was to identify and characterise local/regional geo...

  10. Grow Together under the Sunshine——The 4th Summer Camp for AIDS Orphaned Children

    Institute of Scientific and Technical Information of China (English)

    NING LILI

    2007-01-01

    @@ The 4th summer camp for AIDS-orphaned children was held in Beijing from August 2-8,2007.Co-sponsored by the China Youth Concern Commission and China Foundation for the Prevention and Control of STDs (sexually transmitted disease) and AIDS,the event was attended by 80 AIDS-orphaned children aged 8-16 from 18 counties and cities of 8 provinces of Shanxi,Yunnan,Henan,Jilin,Liaoning,Guizhou,Sichuan and Anhui.

  11. Analisis Pengaruh Strategi Bauran Pemasaran Jasa Terhadap Kepuasan Konsumen (Studi Kasus Konsumen Kampung Ladang Outbound Camp).

    OpenAIRE

    Safrin, Feby Aulia

    2015-01-01

    Customer satisfaction is very important to the sustainability of a business, especially a business in tourism services. In order to enhance customer satisfaction, companies must be able to understand market demand, supported by good marketing strategy. This can be done by applying marketing mix. Kampung Ladang Outbound Camp is a leading provider of outbound travel services. Founded in 2008, Kampung Ladang become place for outbound tourism for Medan people and surrounding. This research servi...

  12. Repression and punishment in North Korea: survey evidence of prison camp experiences

    OpenAIRE

    Noland, Marcus; Haggard, Stephan

    2009-01-01

    The penal system has played a central role in the North Korean government’s response to the country’s profound economic and social changes. Two refugee surveys—one conducted in China, one in South Korea—document its changing role. The regime disproportionately targets politically suspect individuals, particularly those involved in market-oriented economic activities. Levels of violence and deprivation do not appear to differ substantially between the infamous political prison camps, penitenti...

  13. Propionibacterium acnes CAMP factor and host acid sphingomyelinase contribute to bacterial virulence: potential targets for inflammatory acne treatment.

    Directory of Open Access Journals (Sweden)

    Teruaki Nakatsuji

    Full Text Available BACKGROUND: In the progression of acne vulgaris, the disruption of follicular epithelia by an over-growth of Propionibacterium acnes (P. acnes permits the bacteria to spread and become in contact with various skin and immune cells. METHODOLOGY/PRINCIPAL FINDINGS: We have demonstrated in the present study that the Christie, Atkins, Munch-Peterson (CAMP factor of P. acnes is a secretory protein with co-hemolytic activity with sphingomyelinase that can confer cytotoxicity to HaCaT keratinocytes and RAW264.7 macrophages. The CAMP factor from bacteria and acid sphingomyelinase (ASMase from the host cells were simultaneously present in the culture supernatant only when the cells were co-cultured with P. acnes. Either anti-CAMP factor serum or desipramine, a selective ASMase inhibitor, significantly abrogated the P. acnes-induced cell death of HaCaT and RAW264.7 cells. Intradermal injection of ICR mouse ears with live P. acnes induced considerable ear inflammation, macrophage infiltration, and an increase in cellular soluble ASMase. Suppression of ASMase by systemic treatment with desipramine significantly reduced inflammatory reaction induced by intradermal injection with P. acnes, suggesting the contribution of host ASMase in P. acnes-induced inflammatory reaction in vivo. Vaccination of mice with CAMP factor elicited a protective immunity against P. acnes-induced ear inflammation, indicating the involvement of CAMP factor in P. acnes-induced inflammation. Most notably, suppression of both bacterial CAMP factor and host ASMase using vaccination and specific antibody injection, respectively, cooperatively alleviated P. acnes-induced inflammation. CONCLUSIONS/SIGNIFICANCE: These findings envision a novel infectious mechanism by which P. acnes CAMP factor may hijack host ASMase to amplify bacterial virulence to degrade and invade host cells. This work has identified both CAMP factor and ASMase as potential molecular targets for the development of drugs

  14. Blood Glucose Levels and Performance in a Sports Camp for Adolescents with Type 1 Diabetes Mellitus: A Field Study

    OpenAIRE

    Dylan Kelly; Hamilton, Jill K.; Michael C Riddell

    2010-01-01

    Background. Acute hypo- and hyperglycemia causes cognitive and psychomotor impairment in individuals with type 1 diabetes mellitus (T1DM) that may affect sports performance. Objective. To quantify the effect of concurrent and antecedent blood glucose concentrations on sports skills and cognitive performance in youth with T1DM attending a sports camp. Design/Methods. 28 youth (ages 6–17 years) attending a sports camp carried out multiple skill-based tests (tennis, basketball, or soccer skills)...

  15. Race and Racism: British Responses to Civilian Prison Camps in the Boer War and the Kenya Emergency

    OpenAIRE

    Lally, Erica

    2015-01-01

    During both the Boer War (1899-1902) and the Kenya Emergency (1952-1960), British authorities responded to nationalist movements by adopting a policy of total war that included imprisonment of suspected conspirators and civilians alike in overcrowded detention camps with inadequate facilities and high mortality rates. During both conflicts, women activists – Emily Hobhouse in 1901 and Barbara Castle in 1955 – spearheaded campaigns, demanding official, independent inquiries into camp condition...

  16. Exchange Protein Activated by cAMP Enhances Long-Term Memory Formation Independent of Protein Kinase A

    Science.gov (United States)

    Ma, Nan; Abel, Ted; Hernandez, Pepe J.

    2009-01-01

    It is well established that cAMP signaling within neurons plays a major role in the formation of long-term memories--signaling thought to proceed through protein kinase A (PKA). However, here we show that exchange protein activated by cAMP (Epac) is able to enhance the formation of long-term memory in the hippocampus and appears to do so…

  17. High adenylyl cyclase activity and in vivo cAMP fluctuations in corals suggest central physiological role

    OpenAIRE

    Barott, K.L.; Helman, Y.; Haramaty, L.; Barron, M. E.; Hess, K.C.; Buck, J.; Levin, L. R.; Tresguerres, M.

    2013-01-01

    Corals are an ecologically and evolutionarily significant group, providing the framework for coral reef biodiversity while representing one of the most basal of metazoan phyla. However, little is known about fundamental signaling pathways in corals. Here we investigate the dynamics of cAMP, a conserved signaling molecule that can regulate virtually every physiological process. Bioinformatics revealed corals have both transmembrane and soluble adenylyl cyclases (AC). Endogenous cAMP levels in ...

  18. Assessment of physical education model in summer health-improving camp, aimed at cultivating interest to physical exercises in teenagers

    OpenAIRE

    Yezersky V. I.

    2010-01-01

    Article presents characteristic of teenagers' physical education model in summer health-improving camp, which provides social-pedagogical conditions for cultivating interest in physical exercises. This model is based on realization of principles of systematic, activity and person-oriented approaches to development of physical culture of a person. Assessment of teenagers' attitude to educational health-improving physical activities in summer health-improving camp is presented basing on results...

  19. Predicting Stress Related to Basic Needs and Safety in Darfur Refugee Camps: A Structural and Social Ecological Analysis

    OpenAIRE

    Rasmussen, Andrew; Annan, Jeannie

    2009-01-01

    The research on the determinants of mental health among refugees has been largely limited to traumatic events, but recent work has indicated that the daily hassles of living in refugee camps also play a large role. Using hierarchical linear modelling to account for refugees nested within camp blocks, this exploratory study attempted to model stress surrounding safety and acquiring basic needs and functional impairment among refugees from Darfur living in Chad, using individual-level demograph...

  20. Isolation of an inactive bovine heart cAMP-dependent protein kinase holoenzyme containing bound cAMP

    International Nuclear Information System (INIS)

    Bovine heart Type II cAMP-dependent protein kinase (PK) was purified to homogeneity as determined by SDS-PAGE. The purification steps were DEAE-cellulose, ammonium sulfate precipitation, phenyl-Sepharose, alumina C-γ, and HPLC-DEAE. The last step resolved two distinct peaks of cAMP dependent kinase activity (activity ratios = 0.05 - 0.10) eluting at approximately 250 (Peak 1) and 275 (Peak 2) mM NaCl. When subjected to HPLC-gel permeation they had the same Stoke's radii. Linear sucrose gradients gave S/sub 20,w/ values of 7.73 S and 7.25 S for Peaks 1 and 2, respectively. It was determined by integrating the areas of scanned SDS-PAGE bands that regulatory and catalytic subunits were present in equimolar amounts in both Peaks 1 and 2. The ratios of equilibrium [3H] cAMP binding to kinase activity for the two peaks were the same. cAMP was present in trace amounts in Peak 1 but in stoichiometric amounts in Peak 2 (between 25 and 75 % saturation of cAMP binding sites). Although SDS-PAGE analysis ruled out conversions by proteolysis or autophosphorylation-dephosphorylation, Peak 1 could be partially converted to Peak 2 by the addition of subsaturating amounts of cAMP, 3H] cAMP binding and in kinase activation (as indicated by a larger Hill coefficient) of Peak 2 relative to Peak 1 also supported the presence of cAMP in Peak 2. In conclusion, two forms of inactive PK have been isolated, one of which is a ternary complex of PK holoenzyme and cAMP. This complex could represent a cellular form of the enzyme which is primed for activation

  1. Assessment of physical education model in summer health-improving camp, aimed at cultivating interest to physical exercises in teenagers

    Directory of Open Access Journals (Sweden)

    Yezersky V. I.

    2010-03-01

    Full Text Available Article presents characteristic of teenagers' physical education model in summer health-improving camp, which provides social-pedagogical conditions for cultivating interest in physical exercises. This model is based on realization of principles of systematic, activity and person-oriented approaches to development of physical culture of a person. Assessment of teenagers' attitude to educational health-improving physical activities in summer health-improving camp is presented basing on results of conducted survey.

  2. Looking Outside: Summer Camp for Children Who Have Undergone a Solid-Organ Transplant.

    Science.gov (United States)

    Bilhartz, Jacob L; Drayton, Amy K; Shieck, Victoria L

    2016-01-01

    A high-quality critical care team is an essential component of any successful organ transplant program. From pretransplant care to the crucial postoperative period, its importance cannot be discounted. However, because of the focused nature of work in an intensive care unit (ICU), all too often members of the ICU team are not able to see and appreciate the ultimate fruits of their labor. These are factors that can contribute to the high rates of burnout and turnover among ICU teams. This article presents the concept of a summer camp for children who have received a solid-organ transplant. We discuss a vehicle by which ICU staff as well as other members of a patient's care team can gain a better appreciation of the full nature of both medical and, perhaps more importantly in this situation, nonmedical goals and outcomes in pediatric transplantation. We review our institutional experience running a summer camp for these children, discuss some of the important points in making such a camp successful, and discuss potential benefits to the campers as well as those taking care of them. PMID:27254644

  3. Dermatologic challenges of health care for displaced people. lessons from a German emergency refugee camp

    Directory of Open Access Journals (Sweden)

    Uwe Wollina

    2016-04-01

    Full Text Available Background: The World faces the highest waves of displaced people since World War II. There is limited knowledge about need of dermatological care for refugees and asylum seekers. Methods: We report the experience with a temporary emergency refugee camp in Dresden form the viewpoint of a hospital department. This is a descriptive report covering the period of 10 weeks. Results: In this refugee camp up to 1 100 people were hosted. The male to female ratio was 5.3. The majority of inhabitants were young males (60%, 20% were children. While 40% of refuges came from Syria, Afghanistan, Iraq and Pakistan were also important countries of origin. Communication war a crucial issue while providing health care. Dermatologic service was granted as consultation, outpatient and inpatient clinic. Most contacts were noted in the outpatient clinic. The majority of patient attended the clinic with communicable diseases such as bacterial or viral infections and infestations. Wounds and chronic inflammatory diseases were rather uncommon. Only 4 patients had to be treated in the hospital (inpatient clinic. Conclusions: Displaced people (refugees, asylum seekers come in big waves to Europe. Dermatologic service is an important part of first aid health care in an emergency camp. Language barriers and cultural barriers have to overcome for optimal service. This is the first report from Germany.

  4. Radioligand assay on β-adrenoreceptor, AC and cAMP levels during myocardial ischemia

    International Nuclear Information System (INIS)

    To investigate β-adrenoreceptor (β-AR) signal transduction during myocardial ischemia and the effect of Sini Decoction, the β-AR was blocked by propranolol, myocardial ischemia was induced by giving a booster dose of pituitrin in rats. The density of β-AR was detected by radioligand binding assay. The AC activity on cardiac cellular membranes and cAMP level in plasma and myocardium was detected by RIA. The results showed that the density of β-AR in myocardial ischemia groups was up-regulated (P < 0.01), but the AC activity and cAMP levels in plasma and myocardium in myocardial ischemia group were lower than normal control group (P < 0.01). The Sini Decoction (SD) can increase the density of β-AR on cardiac cellular membranes and cAMP levels in plasma (P < 0.01). Sini Decoction can reduce the desensitization of β-AR during myocardial ischemia and improve signal transduction of β-AR

  5. Diatom acclimation to elevated CO2 via cAMP signalling and coordinated gene expression

    Science.gov (United States)

    Hennon, Gwenn M. M.; Ashworth, Justin; Groussman, Ryan D.; Berthiaume, Chris; Morales, Rhonda L.; Baliga, Nitin S.; Orellana, Mónica V.; Armbrust, E. V.

    2015-08-01

    Diatoms are responsible for ~40% of marine primary productivity, fuelling the oceanic carbon cycle and contributing to natural carbon sequestration in the deep ocean. Diatoms rely on energetically expensive carbon concentrating mechanisms (CCMs) to fix carbon efficiently at modern levels of CO2 (refs , , ). How diatoms may respond over the short and long term to rising atmospheric CO2 remains an open question. Here we use nitrate-limited chemostats to show that the model diatom Thalassiosira pseudonana rapidly responds to increasing CO2 by differentially expressing gene clusters that regulate transcription and chromosome folding, and subsequently reduces transcription of photosynthesis and respiration gene clusters under steady-state elevated CO2. These results suggest that exposure to elevated CO2 first causes a shift in regulation, and then a metabolic rearrangement. Genes in one CO2-responsive cluster included CCM and photorespiration genes that share a putative cAMP-responsive cis-regulatory sequence, implying these genes are co-regulated in response to CO2, with cAMP as an intermediate messenger. We verified cAMP-induced downregulation of CCM gene δ-CA3 in nutrient-replete diatom cultures by inhibiting the hydrolysis of cAMP. These results indicate an important role for cAMP in downregulating CCM and photorespiration genes under elevated CO2 and provide insights into mechanisms of diatom acclimation in response to climate change.

  6. Cartographies of the Political Camp of Afro-Descendents in Latin America

    Directory of Open Access Journals (Sweden)

    Agustín Lao-Montes

    2009-07-01

    Full Text Available This article lays out, in general terms, what it calls the political camp of Afro-descendents in Latin America. After establishing a series of theoretical and methodological criteria for the historical analysis of black movements in modernity and the Afro-American movements in particular, the article focuses on the emergence of afro-descendant movements in Latin America during the last part of the 1980s. One of the principal arguments is that in the 1990s a political camp of afro-descendents starts to emerge in the region of Latin America based on a series of developments, including the emergence of new social movements that included ethno-racial movements of Afros and indigenous people, events of regional importance like the contra-celebration of 1492 in 1992, the World Conference against Racism 2001 in Durban, South Africa, and the effects of the neoliberal pattern of globalization. The political camp of Afro-descendents is composed not only of social movements, but also of state actors and transnational actors (such as the World Bank and the Ford Foundation. The article concludes with an analysis of the challenges and perspectives of Afro-American politics in general and of Afro-Latin movements in particular considering the current crisis of the modern/colonial world-system.

  7. Traditional Geology Field Camp: A capstone course at South Dakota School of Mines and Technology (BHNSFS)

    Science.gov (United States)

    Uzunlar, N.; Lisenbee, A. L.

    2012-12-01

    The Black Hills Natural Sciences Field Station (BHNSFS) has provided field training in geology and geological engineering for more than 40 years, and since the 1980's as a consortium serving five schools with South Dakota School of Mines and Technology as the coordinator. The traditional summer geology field camp is a five week long, intense program aimed to prepare students for subsequent professional geologic experiences. It is delivered from two separate facilities, one in the Black Hills (South Dakota) from a beautiful log lodge along Sand Creek, in eastern Wyoming, and a second from the town of Taskesti along the North Anatolian fault approximately 200 km east of Istanbul, Turkey. At both locations, the courses maintain a strong emphasis on basic field applications, including the use of GPS as a mapping tool in most exercises. The preparation of well-written reports, based on field descriptions supplemented by research on the web or through published documents, is strongly emphasized. Projects at the Black Hills field camp includes mapping of Precambrian basement, Paleozoic stratigraphy, and Laramide Tertiary plutons and structural features as welll as post-Laramide,, faulted continental strata. The popular Taskesti field camp utilizes the diverse geology of the Tethyan realm, as well as the culture and history, of central Turkey (Anatolia). The course is based at a Turkish Government Earthquake Research Center facility along the North Anatolian fault. Students examine and map selected locations across the Izmir-Ankara suture including: 1) Deformed Cretaceous and Tertiary carbonate and clastic strata of the Sakarya micro-continent in a fore-arc basin; 2) Marble and skarn surrounding Eocene, subduction-related granite intruded into a passive margin sequence in the Sivrihisar region of central Anatolia; 3) Faulted and folded Neogene strata in the northern flank of the post-Tethyan, Haymana Basin and the contrasting terrains across the North Anatolian fault (J

  8. Preliminary Outcomes from a Week-Long Environmental Engineering Summer Camp for High School Female Students

    Science.gov (United States)

    Balasubramanian, S.; Koloutsou-Vakakis, S.

    2014-12-01

    There is a need for environment engineers and sustainability managers to address global environmental, energy and health challenges. Environmental literacy programs at K-12 level provide a unique opportunity in motivating young minds in joining STEM and also provide additional value in learning about "saving planet earth". The Women in Engineering at the University of Illinois organize an annual week long camp, for female high school students with tracks corresponding to different fields of Engineering. The Environmental Engineering and Sustainability (EES) track is organized by faculty and graduate students of the Civil and Environmental Engineering department and introduces students to concepts in sustainability and systems thinking in connection with air and water quality, climate change and renewable energy. This study is a preliminary assessment of the relevance of the EES outreach track conducted in July 2014 in student learning. Specific goals include assessing (a) demographics of participants and their motivation to join this camp, (b) educational and enjoyability quotients of the modules and (c) learning and motivational outcomes using the Likert scale. A pre-camp survey indicated keen interest in learning about environmental engineering (4.56/5.0) and expected this camp to be a venue to learn about related career choices (4.9/5.0). Five days of instruction were divided thematically and included a mix of lectures, activity based learning, demonstrations and field visits. Overall modules were rated as educational (4.4/5.0) and enjoyable (4.5/5.0). Modules with hands-on learning were best received (4.67/5.0) and rated unique (4.7/5.0). Post camp, participants acknowledged the important contribution of environmental engineers to society (4.8/5.0) and could relate the different modules to the role engineer's play (4.06/5.0) for sustainability. On an average, the participants evinced interest in engineering as a career choice (4.0/5.0) but there was a broader

  9. Effect of cAMP on short-circuit current in isolated human ciliary body

    Institute of Scientific and Technical Information of China (English)

    WU Ren-yi; MA Ning; HU Qian-qian

    2013-01-01

    Background Cyclic adenosine monophosphate (cAMP) could activate chloride channels in bovine ciliary body and trigger an increase in the ionic current (short-circuit current,Isc) across the ciliary processes in pigs.The purpose of this study was to investigate how cAMP modulates Isc in isolated human ciliary processes and the possible involvement of chloride transport across the tissue in cAMP-induced Isc change.Methods In an Ussing-type chamber system,the Isc changes induced by the cAMP analogue 8-bromo-cAMP and an adenylyl cyclase activator forskolin in isolated human ciliary processes were assessed.The involvement of Cl-component in the bath solution was investigated.The effect of Cl-channel (10 μmol/L niflumic acid and 1 mmol/L 4,4′-diisothiocyanostilbene-2,2′-disulfonic acid (DIDS)),K+ channel (10 mmol/L tetraethylammonium chloride (TEA)),or Na+ channel blockers (1 mmol/L amiloride) on 8-bromo-cAMP-induced Isc change was also studied.Results Dose-dependently,8-bromo-cAMP (10 nmol/L-30 μmol/L) or forskolin (10 nmol/L-3 μmol/L) increased Isc across the ciliary processes with an increase in negative potential difference on the non-pigmented epithelium (NPE) side of the tissue.Isc increase induced by 8-bromo-cAMP was more pronounced when the drug was applied on the NPE side than on the pigmented epithelium side.When the tissue was bathed in low Cl-solutions,the Isc increase was significantly inhibited.Finally,niflumic acid and DIDS,but not TEA or amiloride,significantly prevented the Isc increase induced by 8-bromo-cAMP.Conclusions cAMP stimulates stroma-to-aqueous anionic transport in isolated human ciliary processes.Chloride is likely to be among the ions,the transportation of which across the tissue is triggered by cAMP,suggesting the potential role of cAMP in the process of aqueous humor formation in human eyes.

  10. Ethics Camp: The Appropriate Management Model for Northeastern Region Youth, Ecclesiastical Region 9

    Directory of Open Access Journals (Sweden)

    Wongsathit Wisupee

    2011-01-01

    Full Text Available Problem statement: Youth’s ethics tended to be a continuous increased problem and they were in their age without judgment. Youths were very important for national development in future, if their problems were not urgently solved it would overall effect to way of live in their families, communities, socials and Thailand. Approach: This research aimed to study backgrounds, current conditions, problems on management and the appropriate management model of Ethics Camp for the Northeastern Region Youth, Ecclesiastical Region 9. The study was a qualitative research conducted in 4 provinces 1 place of the Northeastern Region Youth, Ecclesiastical Region 9 and Thailand. Observation form, survey form, interview form, focus group discussion and study shop were used as research tools. Triangulation was used to test all data and data was analyzed by descriptive research. Results: The result founded that the background in overall of 4 places were began by making study trips of directors or lecturing monks at famous camp and they, later, brought those models back to establish ethics camps in their own provinces. For current conditions and problems, it was found that; in aspect of personnel-there was lacking of competent personnel, in aspect of budget-there was lacking of budget for expenses, in aspect of material-some place had old and damaged equipments, in aspect of management-there was not enough budget for long-term training and also lacking of lecturing monks, in aspect of marketing-there was lacking of public relation and distinct documents of courses and in aspect of technological innovation-lecturing monks had no knowledge to produce modern technological media. For appropriate management model, it was found that; in aspect of personnel-camp directors should have wide and long vision, intelligence, perseverance, honesty and human relation while lecturing monks must be professional; in aspect of budget-charges for any expenses should be depended on

  11. Contos de Camp Wilde: tornando queer a pesquisa em educação ambiental Tales from Camp Wilde: queer(ying environmental education research

    Directory of Open Access Journals (Sweden)

    Noel Gough

    2011-04-01

    Full Text Available Este artigo questiona o relativo silêncio da teoria e da teorização queer sobre a pesquisa em educação ambiental. Exploramos algumas possibilidades para tornar queer a pesquisa em educação ambiental ao criar (estimulando outras/os a fazer o mesmo narrativas de Camp Wilde, um local imaginário que nos ajuda a expor o fato de este ser um campo marcado por uma construção heteronormativa. Essas narrativas propõem métodos alternativos de representação e (reprodução do sujeito e do objeto de nossas indagações e nossas identidades como pesquisadoras/es. As/os colaboradoras/es utilizam-se de diferentes recursos teóricos como história da arte, desconstrução, ecofeminismo, crítica literária, estudos culturais populares e pós-estruturalismo feminista a fim de desenvolver uma nova orientação para a pesquisa em Educação Ambiental, a qual esperamos que jamais seja categorizada como um 'novo gênero'.This paper questions the relative silence of queer theory and theorizing in environmental education research. We explore some possibilities for queering environmental education research by fabricating (and inviting colleagues to fabricate stories of Camp Wilde, a fictional location that helps usto expose the facticity of the field's heteronormative constructedness. These stories suggest alternative ways of (representing and (reproducing both the subjects/objects of our inquiries and our identities as researchers. The contributors draw on a variety of theoretical resources from art history, deconstruction, ecofeminism, literary criticism, popular cultural studies, and feminist poststructuralism to perform an orientation to environmental education research that we hope will never be arrested by its categorization as a "new genre."

  12. cAMP induction by ouabain promotes endothelin-1 secretion via MAPK/ERK signaling in beating rabbit atria

    Science.gov (United States)

    Peng, Li-qun; Li, Ping; Zhang, Qiu-li; Hong, Lan; Liu, Li-ping

    2016-01-01

    Adenosine 3',5'-cyclic monophosphate (cAMP) participates in the regulation of numerous cellular functions, including the Na+-K+-ATPase (sodium pump). Ouabain, used in the treatment of several heart diseases, is known to increase cAMP levels but its effects on the atrium are not understood. The aim of the present study was to examine the effect of ouabain on the regulation of atrial cAMP production and its roles in atrial endothelin-1 (ET-1) secretion in isolated perfused beating rabbit atria. Our results showed that ouabain (3.0 µmol/L) significantly increased atrial dynamics and cAMP levels during recovery period. The ouabain-increased atrial dynamics was blocked by KB-R7943 (3.0 µmol/L), an inhibitor for reverse mode of Na+-Ca2+ exchangers (NCX), but did not by L-type Ca2+ channel blocker nifedipine (1.0 µmol/L) or protein kinase A (PKA) selective inhibitor H-89 (3.0 µmol/L). Ouabain also enhanced atrial intracellular cAMP production in response to forskolin and theophyline (100.0 µmol/L), an inhibitor of phosphodiesterase, potentiated the ouabain-induced increase in cAMP. Ouabain and 8-Bromo-cAMP (0.5 µmol/L) markedly increased atrial ET-1 secretion, which was blocked by H-89 and by PD98059 (30 µmol/L), an inhibitor of extracellular-signal-regulated kinase (ERK) without changing ouabain-induced atrial dynamics. Our results demonstrated that ouabain increases atrial cAMP levels and promotes atrial ET-1 secretion via the mitogen-activated protein kinase (MAPK)/ERK signaling pathway. These findings may explain the development of cardiac hypertrophy in response to digitalis-like compounds. PMID:26807018

  13. Klonierung, Sequenzierung und Charakterisierung der genetischen Determinante des CAMP-Faktors (=cbf-Gen) der Gruppe-B-Streptokokken (Streptococcus agalactiae)

    OpenAIRE

    Blankenstein, Oliver

    2005-01-01

    The CAMP reaction, a synergistic lysis of sheep erythrocytes by Staphylococcus aureus (beta-toxin) and group B streptococci (Streptococcus agalactiae) was first described in 1944 by Christie et al.. This phenomenon is caused by the CAMP-factor, an extra-cellular protein which role pathogenicity and virulence is still unknown. The focus of this work is the molecular isolation and characterization of the CAMP-factor gene of group B streptococci (cbf-Gene). First cloning attempts were made using...

  14. Mental, neurological, and substance use problems among refugees in primary health care: analysis of the Health Information System in 90 refugee camps

    OpenAIRE

    Kane, Jeremy C.; Ventevogel, Peter; Spiegel, Paul; Bass, Judith K; van Ommeren, Mark; Tol, Wietse A.

    2014-01-01

    Background Population-based epidemiological research has established that refugees in low- and middle-income countries (LMIC) are at increased risk for a range of mental, neurological and substance use (MNS) problems. Improved knowledge of rates for MNS problems that are treated in refugee camp primary care settings is needed to identify service gaps and inform resource allocation. This study estimates contact coverage of MNS services in refugee camps by presenting rates of visits to camp pri...

  15. Queering Conversation: An Ethnographic Exploration of The Functional Properties of Camp-­Based Language Use in U.S. Gay Men's Interactions

    OpenAIRE

    Kelley, Jeremy Carl

    2013-01-01

    This multi-sited ethnographic study explores U.S. gay men's interactional usages of camp, a queer aesthetic and sociopolitical mode of expressivity that reframes and transforms dominant, heterosexual-constrained communicative conventions and reality through queer forms of experience. Differing from earlier work on camp, which primarily explored the subject from the perspective of cultural studies, the current analyses are premised upon the examination of camp as a product of talk-in-interacti...

  16. Calcium-linked increase in coupled cAMP synthesis and hydrolysis is an early event in cholinergic and. beta. -adrenergic stimulation of parotid secretion

    Energy Technology Data Exchange (ETDEWEB)

    Deeg, M.A.; Graeff, R.M.; Walseth, T.F.; Goldberg, N.D. (Univ. of Minnesota, Minneapolis (USA))

    1988-11-01

    The dynamics and compartmental characteristics of cAMP metabolism were examined by {sup 18}O labeling of cellular adenine nucleotide {alpha} phosphoryls in rat parotid gland stimulated to secrete with {beta}-adrenergic and cholinergic agents. The secretory response occurred in association with a rapidly increased rate of cAMP hydrolysis apparently coordinated with an equivalent increase in the rate of cAMP synthesis, since the cellular concentration of cAMP remained unchanged. The magnitude of this metabolic response was equivalent to the metabolism of 10-75 times the cellular content of cAMP within the first minute of stimulation. This increased metabolic rate occurred only during the early (1-3 min) period of stimulation, in what appeared to be an exclusive cellular compartment distinguished by a unique distribution of {sup 18}O among adenine nucleotide {alpha} phosphoryls. This {sup 18}O distribution contrasted with that produced by forskolin, which increased cellular cAMP concentration and elicited only a delayed response missing the early secretory component. The early acceleration of cAMP metabolism appeared linked to a stimulus-induced increase in intracellular Ca{sup 2+} concentration, since the Ca{sup 2+} ionophore ionomycin produced the same metabolic response in association with secretion. These observations suggest that cAMP metabolism is involved in stimulus-secretion coupling by a Ca{sup 2+}-linked mechanism different from that in which cAMP plays the role of a second messenger.

  17. Calcium-linked increase in coupled cAMP synthesis and hydrolysis is an early event in cholinergic and β-adrenergic stimulation of parotid secretion

    International Nuclear Information System (INIS)

    The dynamics and compartmental characteristics of cAMP metabolism were examined by 18O labeling of cellular adenine nucleotide α phosphoryls in rat parotid gland stimulated to secrete with β-adrenergic and cholinergic agents. The secretory response occurred in association with a rapidly increased rate of cAMP hydrolysis apparently coordinated with an equivalent increase in the rate of cAMP synthesis, since the cellular concentration of cAMP remained unchanged. The magnitude of this metabolic response was equivalent to the metabolism of 10-75 times the cellular content of cAMP within the first minute of stimulation. This increased metabolic rate occurred only during the early (1-3 min) period of stimulation, in what appeared to be an exclusive cellular compartment distinguished by a unique distribution of 18O among adenine nucleotide α phosphoryls. This 18O distribution contrasted with that produced by forskolin, which increased cellular cAMP concentration and elicited only a delayed response missing the early secretory component. The early acceleration of cAMP metabolism appeared linked to a stimulus-induced increase in intracellular Ca2+ concentration, since the Ca2+ ionophore ionomycin produced the same metabolic response in association with secretion. These observations suggest that cAMP metabolism is involved in stimulus-secretion coupling by a Ca2+-linked mechanism different from that in which cAMP plays the role of a second messenger

  18. The Geothermal Field Camp: Capacity building for geothermal energy systems in Indonesia

    Science.gov (United States)

    Moeck, I.; Sule, R.; Saptadji, N. M.; Deon, F.; Herdianita, N. R.; Jolie, E.; Suryantini, N.; Erbas, K.

    2012-04-01

    In July 2011, the first geothermal field camp was hold on Java/Indonesia near the city Bandung south of the volcanic field Tangkuban Perahu. The course was organized by the Institut Teknologie Bandung (ITB) and International Centre for Geothermal Research (ICGR) of the German Centre of Geosciences (GFZ). The purpose of the Geothermal Field Camp is to combine both field based work and laboratory analysis to ultimately better understand the data collected in field and to integrate data gained by various disciplines. The training belongs to a capacity building program for geothermal energy systems in Indonesia and initially aims to train the trainers. In a later stage, the educational personal trained by the Geothermal Field Camp shall be able to hold their individual Geothermal Field Camp. This is of special interest for Indonesia where the multitude of islands hindered a broad uniform education in geothermal energy systems. However, Indonesia hold the largest geothermal potential worldwide and educated personal is necessary to successfully develop this huge potential scattered over region in future. The interdisciplinary and integrative approach combined with field based and laboratory methodologies is the guiding principle of the Geothermal Field Camp. Tangkuban Perahu was selected because this field allows the integration of field based structural geological analysis, observation and sampling of geothermal manifestations as hot springs and sinters and ultimately of structural geology and surface geochemistry. This innovative training introduces in methods used in exploration geology to study both, fault and fracture systems and fluid chemistry to better understand the selective fluid flow along certain fractures and faults. Field geology covered the systematic measurement of faults and fractures, fault plane and fracture population analysis. In addition, field hydro-geochemistry focused on sampling techniques and field measurements onsite. Subsequent data analysis

  19. Impact of an informal learning science camp on urban, low socioeconomic status middle school students and participating teacher-leaders

    Science.gov (United States)

    Votaw, Nikki L.

    Studies suggest that students have difficulty connecting science to their own lives (Lee & Fradd, 1998; Aikenhead, 1996). This difficulty results in a decline in students' attitudes toward science, leading to low science achievement. These factors result in fewer students interested in careers related to science, specifically for urban, minority students. The purpose of this study was to examine the impact that a ten day informal learning immersion science camp had on the participants, both urban, low-socioeconomic status middle school students and teacher-leaders. The students were incoming seventh grade students involved in a community-based scholar program designed to recruit and support socioeconomically disadvantaged, academically talented students. The teacher-leaders were professional educators working toward an advanced degree. This ten day camp included seven visits to different sites and complementary classroom-based activities. The purpose of the camp was to immerse the students in informal learning environments that affect their daily lives. Students and teacher-leaders visited facilities that provide public utility services (i.e. power plant, sewage treatment facility, and water company), zoo, large commercial cave system, planetarium, university based electrooptics and nanotechnology center, and forest and arboretum. These site visits were supported by activities that were provided by teacher-leaders. A model used as a framework for studying learning in the context of this ten day camp as Falk and Dierking's (2000) Contextual Model for Learning. This model described three basic intersecting elements that contributed to learning within the given context. The three contexts (personal, sociocultural, and physical) intersect affecting the learning that takes place. A mixed methodology design was employed to determine the impact of the camp on students' content knowledge and attitudes toward science. Qualitative data were collected to determine the impact

  20. Membrane estrogen receptor-α levels in MCF-7 breast cancer cells predict cAMP and proliferation responses

    International Nuclear Information System (INIS)

    17β-estradiol (E2) can rapidly induce cAMP production, but the conditions under which these cAMP levels are best measured and the signaling pathways responsible for the consequent proliferative effects on breast cancer cells are not fully understood. To help resolve these issues, we compared cAMP mechanistic responses in MCF-7 cell lines selected for low (mERlow) and high (mERhigh) expression of the membrane form of estrogen receptor (mER)-α, and thus addressed the receptor subform involved in cAMP signaling. MCF-7 cells were immunopanned and subsequently separated by fluorescence activated cell sorting into mERhigh (mER-α-enriched) and mERlow (mER-α-depleted) populations. Unique (compared with previously reported) incubation conditions at 4°C were found to be optimal for demonstrating E2-induced cAMP production. Time-dependent and dose-dependent effects of E2 on cAMP production were determined for both cell subpopulations. The effects of forskolin, 8-CPT cAMP, protein kinase A inhibitor (H-89), and adenylyl cyclase inhibitor (SQ 22,536) on E2-induced cell proliferation were assessed using the crystal violet assay. We demonstrated a rapid and transient cAMP increase after 1 pmol/l E2 stimulation in mERhigh cells; at 4°C these responses were much more reliable and robust than at 37°C (the condition most often used). The loss of cAMP at 37°C was not due to export. 3-Isobutyl-1-methylxanthine (IBMX; 1 mmol/l) only partially preserved cAMP, suggesting that multiple phosphodiesterases modulate its level. The accumulated cAMP was consistently much higher in mERhigh cells than in mERlow cells, implicating mER-α levels in the process. ICI172,780 blocked the E2-induced response and 17α-estradiol did not elicit the response, also suggesting activity through an estrogen receptor. E2 dose-dependent cAMP production, although biphasic in both cell types, was responsive to 50-fold higher E2 concentrations in mERhigh cells. Proliferation of mERlow cells was stimulated

  1. Tabud ja reeglid. Sissevaateid eesti laagriromaani / Taboos and Rules. Insights into Prison Camp Novels by Estonian Writers

    Directory of Open Access Journals (Sweden)

    Anneli Kõvamees

    2013-12-01

    Full Text Available The article concentrates on Estonian novels depicting Soviet prison camps in the 1940s and 1950s. The goal is to map themes, motifs and characteristics in such novels, concentrating on various taboos and rules in the prison camp environment. For a long time the Soviet prison camp theme was not publicly discussed in Estonia due to political reasons. Texts dealing with prison camps could appear in print only outside the Soviet Union; the way Estonians saw these historical events and hellish experiences were depicted mostly in exile novels. Most notable are the novels by Arved Viirlaid (b. 1922, e.g., Kes tappis Eerik Hormi? (Who Killed Eerik Horm? (1974, Surnud ei loe (The Dead do not Read (1975, Vaim ja ahelad (Mind and Chains (1961.Estonian prison camp novels can be seen as “the literature of testimony”, to use the term by Leona Toker. Dramatic historical events are written down to record the events and to show the inhumane nature of Soviet society. These records of the dramatic past follow certain patterns and create certain self- and hetero-images.A prison camp is a closed territory within a closed territory; prison camps can be seen as small models of Soviet society. Prison camp novels give a detailed view of the environment of the prison camp, its inhabitants and activities. Two central aspects are labour and food; the life of the prisoner whirls around these. The most important thing is to survive, which often leads to moral decline, e.g., stealing, cheating. However, there are lines Estonians do not cross, e.g., cannibalism or homosexual relationships with superiors. Estonians are always depicted as political prisoners (not common criminals and heterosexuals, while Russians are portrayed mainly as criminals and often also as homosexuals. Another important component of the image of the Estonians is their enterprising spirit and ability to manage even under very difficult conditions. Therefore, several oppositions can be identified, e

  2. [The infectious diseases experiments conducted on human guinea pigs by Nazis in concentration camps].

    Science.gov (United States)

    Sabbatani, Sergio

    2013-06-01

    The author systematically examined all available publications and web documents, with regard to scientifically documented experiments carried out by Nazi physicians in their concentration camps during World War II. This research focused on human experiments dealing with: malaria, tuberculosis, petechial typhus, viral hepatitis, and those regarding sulphonamides as antimicrobial agents. The concentration camps involved by experimental programmes on human guinea pigs were: Natzweiler Struthof, Dachau, Mauthausen, Buchenwald, Neuengamme, Ravensbrück, Sachsenhausen and Auschwitz. Overall, around 7,200 deported prisoners went to their deaths during or because of these experiments (also considering human trials other than previously quoted ones). At the end of the war several physicians were charged with war crimes in two trials (Nuremberg and Dachau), and those found guilty were sentenced to death, or years of imprisonment. Some of them, including the notorious Josef Mengele, succeeded in escaping capture and being brought to justice. Thanks to these trials, partial light has been shed on these crimes, which not infrequently had children as designated victims, selected with excruciating cruelty in special segregation sections. The SS was the key structure which ensured maximum efficiency for these experimental programmes, from both logistic planning through to an operative control system carried out in concentration camps, and thanks to an autonomous, dedicated medical structure, which included a rigid hierarchy of physicians directly dependent on the head of SS forces (Reichsführer), i.e. Dr. Heinrich Himmler. Moreover, it is worth noting that also physicians who were not part of the SS corps collaborated in the above experiments on human guinea pigs: these included military personnel belonging to the Wehrmacht, academic physicians from German universities, and researchers who worked in some German pharmaceutical industries, such as IG Farben, Bayer and Boehring

  3. Characterization of the insulin-sensitive low Km cAMP phosphodiesterase from rat adipose tissue

    International Nuclear Information System (INIS)

    Particulate, but not soluble, low K/sub m/ cAMP phosphodiesterase (PDE) activity of rat adipocytes was increased 50-100% during incubation (10 min) of intact cells with 1-3 nM insulin; activation was less with higher or lower insulin concentrations. Activation was maintained during solubilization with an alkyl polyoxyethylene non-ionic detergent C13, E12 and NaBr and chromatography on DEAE. Enzyme from DEAE was further purified by chromatography on Sepahadex G-200 and Blue-Sepharose. Activity (with 0.5 μM [3H]cAMP) was rather sensitive to inhibition by p-chloromercuribenzoate (IC50, 1 μM) and less so by 2,2'-dithiobis-(5-nitropyridine) (160 μM), N-ethylmaleimide (525 μM) and iodoacetamide (750 μM). PDE activity was also rather sensitive to inhibition by cilostamide (IC50, ∼40 nM) and the cardiotonic drugs CI 930 (450 nM) and milrinone (630 nM) but rather insensitive to RO 20-1724 (190 μM). Based on effects of these inhibitors, the hormone-sensitive low K/sub m/ particulate cAMP PDE from rat adipocytes seems to be analogous to the insulin-activated particulate PDE from 3T3-L1 adipocytes and the cilostamide-sensitive soluble low K/sub m/ cAMP PDE from bovine liver (designated as III-C), platelets, heart, and other tissues

  4. Pattern of dermatoses among nicobarese in a community health camp at Nancowry, Andaman and Nicobar Islands

    Directory of Open Access Journals (Sweden)

    Radhakrishnan Subramaniyan

    2016-01-01

    Full Text Available Background: The Andaman and Nicobar Islands are a group of islands to the east of the Indian mainland. The Nicobar district in its southern part includes the Nancowry group. Very little is known about the dermatoses in this remote region and hence, this study was carried out at a community medical camp held in Kamorta on November 12, 2014. Aims: To study the pattern of dermatoses in Nicobarese attending a community medical camp at Nancowry.Subjects and Methods: All Nicobarese, predominantly mongoloid, attending a multi-specialty community medical camp at Kamorta on November 12, 2014, were initially seen by a general practitioner. Persons with dermatologic complaints or the presence of skin lesions were then seen by a single dermatologist. Results: A total of 375 patients were seen. Out of these, 113 cases (30.13% had a skin disorder. Females comprised 50.44% and males 49.56% of the cases. The mean age was 21.28 years. The most common dermatoses were infections and infestations comprising 53 cases (46.9% of which fungal infections were seen in 25 cases (22.12%, pyodermas in 12 cases (10.62%, scabies in 9 cases (7.96%, warts in 4 cases (3.54%, 1 case each of molluscum contagiosum, herpes zoster, and pediculosis capitis (0.88% followed by eczema in 20 cases (17.70%, acne in 13 cases (11.5%, papular urticaria in 9 cases (7.96%, and psoriasis in 3 cases (2.65%. Miscellaneous dermatoses made up the rest of the 15 cases (13.27%. Conclusion: The pattern of dermatoses seen among the Nicobarese is quite similar with respect to the prevalence of infections in other regions of India, especially humid regions such as Assam, coastal Karnataka, and Kolkata and much higher than arid regions such as the deserts of Rajasthan.

  5. Developing knowledge intensive ideas in engineering education: the application of camp methodology

    Science.gov (United States)

    Heidemann Lassen, Astrid; Løwe Nielsen, Suna

    2011-11-01

    Background: Globalization, technological advancement, environmental problems, etc. challenge organizations not just to consider cost-effectiveness, but also to develop new ideas in order to build competitive advantages. Hence, methods to deliberately enhance creativity and facilitate its processes of development must also play a central role in engineering education. However, so far the engineering education literature provides little attention to the important discussion of how to develop knowledge intensive ideas based on creativity methods and concepts. Purpose: The purpose of this article is to investigate how to design creative camps from which knowledge intensive ideas can unfold. Design/method/sample: A framework on integration of creativity and knowledge intensity is first developed, and then tested through the planning, execution and evaluation of a specialized creativity camp with focus on supply chain management. Detailed documentation of the learning processes of the participating 49 engineering and business students is developed through repeated interviews during the process as well as a survey. Results: The research illustrates the process of development of ideas, and how the participants through interdisciplinary collaboration, cognitive flexibility and joint ownership develop highly innovative and knowledge-intensive ideas, with direct relevance for the four companies whose problems they address. Conclusions: The article demonstrates how the creativity camp methodology holds the potential of combining advanced academic knowledge and creativity, to produce knowledge intensive ideas, when the design is based on ideas of experiential learning as well as creativity principles. This makes the method a highly relevant learning approach for engineering students in the search for skills to both develop and implement innovative ideas.

  6. Aclidinium bromide combined with formoterol inhibits remodeling parameters in lung epithelial cells through cAMP.

    Science.gov (United States)

    Lambers, Christopher; Costa, Luigi; Ying, Qi; Zhong, Jun; Lardinois, Didier; Dekan, Gerhard; Schuller, Elisabeth; Roth, Michael

    2015-12-01

    Combined muscarinic receptor antagonists and long acting β2-agonists improve symptom control in chronic obstructive pulmonary disease (COPD) significantly. In clinical studies aclidinium bromide achieved better beneficial effects than other bronchodilators; however, the underlying molecular mechanisms are unknown. This study assessed the effect of aclidinium bromide combined with formoterol on COPD lung (n=20) and non-COPD lung (n=10) derived epithelial cells stimulated with TGF-β1+carbachol on: (i) the generation of mesenchymal cells in relation to epithelial cells, (II) extracellular matrix (ECM) deposition, and (iii) the interaction of ECM on the generation of epithelial and mesenchymal cells. TGF-β1+carbachol enhanced the generation of mesenchymal cells, which was significantly reduced by aclidinium bromide or formoterol. The effect of combined drugs was additive. Inhibition of p38 MAP kinase and Smad by specific inhibitors or aclidinium bromide reduced the generation of mesenchymal cells. In mesenchymal cells, TGF-β1+carbachol induced the deposition of collagen-I and fibronectin which was prevented by both drugs dose-dependently. Formoterol alone reduced collagen-I deposition via cAMP, this however, was overruled by TGF-β1+carbachol and rescued by aclidinium bromide. Inhibition of fibronectin was cAMP independent, but involved p38 MAP kinase and Smad. Seeding epithelial cells on ECM collagen-I and fibronectin induced mesenchymal cell generation, which was reduced by aclidinium bromide and formoterol. Our results suggest that the beneficial effect of aclidinium bromide and formoterol involves cAMP affecting both, the accumulation of mesenchymal cells and ECM remodeling, which may explain the beneficial effect of the drugs on lung function in COPD. PMID:26546746

  7. The impact of occupation on child health in a Palestinian refugee camp.

    Science.gov (United States)

    Basak, Polly

    2012-12-01

    This article focuses on child health in the Palestinian refugee camp of Dheisheh in the West Bank region of the Occupied Palestinian Territories. Thirty in-depth interviews were carried out with parents to determine their perceptions of their children's health. The questions related to physical, mental and social well-being, access to health facilities, factors that were likely to hinder health and measures that could be implemented to improve child health. The study was carried out prior to and during the Gaza War in December 2008 that resulted in the deaths of 1380 Palestinians including 431 children and 112 women [1]. The effects of occupation, conflict and being a refugee had a detrimental impact on perceptions of health. Interviewees revealed that their perceptions of their children's health were determined by the camp's conditions, the current economic climate, past and current political conflict and financial and social restrictions. The understanding of being healthy incorporated physical and mental health as well as social well-being. As a result, 70% of interviewees deemed that their children were not in good health. This finding accelerated to 100% after the Gaza War, showing the negative effect war has on health perceptions. Findings showed that perceptions of physical health are very much interlinked with mental well-being and parents' perceptions of their children's health, and are closely related to their state of mental health. Consequently, a clear correlation can be discerned between the ongoing occupation and its detrimental effects on mental health. Therapeutic and preventive health programmes such as child therapy and stress management that have already been implemented by the Gaza Community Mental Health Programme would be highly beneficial to both children and adults in Dheisheh refugee camp. PMID:22491534

  8. Possibilities of Reducing Greenhouse Gas Emissions in Hotels and Camps Along the Adriatic Coast

    International Nuclear Information System (INIS)

    The article presents a possibility of reducing greenhouse gas emissions in hotels and camps along the Adriatic Coast, through equipment modernisation, efficient use of various energy forms (electric energy, oil, gas) including solar energy. An elaborate quantitative analysis the greenhouse gas emissions and possible ways of reducing them have been carried out in 180 hotels with their own boiler rooms and 70 camps with solar hot water system. The representatives of the two specified groups were chosen in order to perform the quantitative analysis. Considering that the reduction of the carbon emission is the basic condition for the prevention of climate changes, the assumptions were made in line with their reducing. The starting point is that the combustion of a litre of fuel causes 2,5 kg CO2, while the generation of 1 kWh of electric energy and use of 1 m3 of water emit 0,5 kg of CO2 respectively. Thereby it is necessary to bear in mind that the reduction of emissions can be achieved directly in hotel boiler rooms and, in a wider perspective, in plants through the reduction of the electric energy and water consumption, i.e. solar energy consumption The article ends with a review of possible emission reductions which are to be carried out. According to the calculation presented, the share of the reduction of greenhouse gas emission in hotels and camps along the Adriatic Coast principate with 1% in the obligatory 5% emission reduction of the Republic of Croatia till the year 2012 related to the Kyoto Protocol. (author)

  9. A homogeneous single-label time-resolved fluorescence cAMP assay.

    Science.gov (United States)

    Martikkala, Eija; Rozwandowicz-Jansen, Anita; Hänninen, Pekka; Petäjä-Repo, Ulla; Härmä, Harri

    2011-03-01

    G-protein-coupled receptors (GPCRs) are an important class of pharmaceutical drug targets. Functional high-throughput GPCR assays are needed to test an increasing number of synthesized novel drug compounds and their function in signal transduction processes. Measurement of changes in the cyclic adenosine monophosphate (cAMP) concentration is a widely used method to verify GPCR activation in the adenylyl cyclase pathway. Here, a single-label time-resolved fluorescence and high-throughput screening (HTS)-feasible method was developed to measure changes in cAMP levels in HEK293(i) cells overexpressing either β(2)-adrenergic or δ-opioid receptors. In the quenching resonance energy transfer (QRET) technique, soluble quenchers reduce the signal of unbound europium(III)-labeled cAMP in solution, whereas the antibody-bound fraction is fluorescent. The feasibility of this homogeneous competitive assay was proven by agonist-mediated stimulation of receptors coupled to either the stimulatory G(s) or inhibitory G(i) proteins. The reproducibility of the assays was excellent, and Z' values exceeded 0.7. The dynamic range, signal-to-background ratio, and detection limit were compared with a commercial time-resolved fluorescence resonance energy transfer (TR-FRET) assay. In both homogeneous assays, similar assay parameters were obtained when adenylyl cyclase was stimulated directly by forskolin or via agonist-mediated activation of the G(s)-coupled β(2)AR. The advantage of using the single-label approach relates to the cost-effectiveness of the QRET system compared with the two-label TR-FRET assay as there is no need for labeling of two binding partners leading to reduced requirements for assay optimization. PMID:21343601

  10. Evidence that the cAMP pathway controls emergence of both primary and appressorial germ tubes of barley powdery mildew.

    Science.gov (United States)

    Kinane, J; Dalvin, S; Bindslev, L; Hall, A; Gurr, S; Oliver, R

    2000-05-01

    Development of conidia of barley powdery mildew involves the formation of a primary germ tube (PGT), an appressorial germ tube (AGT), and an appressorium. Previously, it was found that cyclic AMP (cAMP) was involved in these developmental processes. Comparison of development on the host surface with two types of cellulose membrane revealed that frequency of PGT emergence was surface independent. On one type of cellulose, where the frequencies of both AGT and appressorial differentiation were similar to that on the host surface, cAMP levels and protein kinase A (PKA) activities had a biphasic pattern with peaks at 15 min and 4 h after inoculation (prior to PGT and AGT emergence, respectively). The effect of manipulating cAMP levels was tested on another type of cellulose membrane, which stimulated a lower degree of AGT and appressorial formation than the host surface. Cholera toxin and forskolin, activators of adenylyl cyclase, significantly increased PGT emergence, but cAMP did not. Cholera toxin, forskolin, and cAMP increased the frequency of AGT and appressorial formation, but in a time-dependent manner. PMID:10796015

  11. STUDY ON THE IDENTIFICATION OF CULTURAL DIMENSIONS RELATED TO THE DECISION FLOW IN THE SPORTS CAMP ORGANIZATION

    Directory of Open Access Journals (Sweden)

    Nichifor F.

    2013-07-01

    Full Text Available This paper proposes to identify the influences of cultural specificity upon managerial decision flows within a sports camp. This influence is analyzed from the perspective of cultural dimensions elaborated by G. Hofstede, F. Trompenaas, and Ed. Hall. This effort represents a pilot-research and the purpose is to elaborate a methodology for assessing the intercultural management of the sports camps in Romania. This research aims to identify the elements of cultural specificity within a sports camp, with a focus on the activity of the manager, of the managerial team, and on the employees’ attitude. We have initiated this research starting from the hypothesis that there exist and that one may use the elements referring to the dimensions elaborated by the aforementioned authors on the level of a sports camp. We may conclude that, through the qualitative and quantitative analysis of the intercultural dimensions, we will emphasize on the dynamic of the cultural influences in the managerial aspect of the sports camp in the geo-cultural area of Moldavia, Romania.

  12. Basal and adenosine receptor-stimulated levels of cAMP are reduced in lymphocytes from alcoholic patients

    International Nuclear Information System (INIS)

    Alcoholism causes serious neurologic disease that may be due, in part, to the ability of ethanol to interact with neural cell membranes and change neuronal function. Adenosine receptors are membrane-bound proteins that appear to mediate some of the effects of ethanol in the brain. Human lymphocytes also have adenosine receptors, and their activation causes increases in cAMP levels. To test the hypothesis that basal and adenosine receptor-stimulated cAMP levels in lymphocytes might be abnormal in alcoholism, the authors studied lymphocytes from 10 alcoholic subjects, 10 age- and sex-matched normal individuals, and 10 patients with nonalcoholic liver disease. Basal and adenosine receptor-stimulated cAMP levels were reduced 75% in lymphocytes from alcoholic subjects. Also, there was a 76% reduction in ethanol stimulation of cAMP accumulation in lymphocytes from alcoholics. Similar results were demonstrable in isolated T cells. Unlike other laboratory tests examined, these measurements appeared to distinguish alcoholics from normal subjects and from patients with nonalcoholic liver disease. Reduced basal and adenosine receptor-stimulated levels of cAMP in lymphocytes from alcoholics may reflect a change in cell membranes due either to chronic alcohol abuse or to a genetic predisposition unique to alcoholic subjects

  13. Identification of secreted proteins regulated by cAMP in glioblastoma cells using glycopeptide capture and label-free quantification.

    Science.gov (United States)

    Hill, Jennifer J; Moreno, Maria J; Lam, Jean C Y; Haqqani, Arsalan S; Kelly, John F

    2009-02-01

    Exposure of glioblastoma U87MG cells to a cAMP analog leads to a decrease in proliferation, invasion, and angiogenic potential. Here, we apply a label-free MS-based approach to identify formerly N-linked glycopeptides that change in abundance upon cAMP treatment. Over 150 unique glycopeptides in three biological repetitions were quantified, leading to the identification of 14 upregulated proteins and 21 downregulated proteins due to cAMP treatment. Of these, eight have been validated, either through comparison with microarray data or by Western blot. We estimate our ability to identify differentially expressed peptides at greater than 85% in a single biological repetition, while the analysis of multiple biological repetitions lowers the false positive rate to approximately 2%. Many of the proteins identified in this study are involved in cell signaling and some, such as Tenascin C, Cathepsin L, Neuroblastoma suppressor of tumorigenicity, and AXL/UFO tyrosine-protein kinase receptor, have been previously shown to be involved in glioblastoma progression. We also identify several semitryptic peptides that increase in abundance upon cAMP treatment, suggesting that cAMP regulates protease activity in these cells. Overall, these results demonstrate the benefits of using a highly specific enrichment method for quantitative proteomic experiments. PMID:19137551

  14. Alan Hollinghurst/Ronald Firbank: Camp Filiation as an Aesthetic of the Outrageous

    OpenAIRE

    Letissier, Georges

    2013-01-01

    Alan Hollinghurst revendique sa parenté littéraire avec l’écrivain édouardien Ronald Firbank qu’il a édité et auquel il a consacré des essais critiques. Firbank apparaît également dans The Swimming Pool Library, le premier roman de Hollinghurst qui en 1988 traitait ouvertement de l’homosexualité masculine alors que Margaret Thatcher avec la Section 28 du Local Government Act menait une politique résolument homophobe. En partant de la notion de Camp (Susan Sontag), reprise par les études Queer...

  15. Access to Safe Water and Personal Hygiene Practices in the Kulandia Refugee Camp (Jerusalem).

    Science.gov (United States)

    Issa, Mohamad; McHenry, Michael; Issa, Abdul Aziz; Blackwood, R Alexander

    2015-12-22

    Diarrheal illness, frequently associated with fecal-oral transmission, is one of the leading causes of death worldwide. It is commonly preventable through the implementation of safe water practices. This experiment concerns how to best implement safe water practices in a quasi-permanent refugee camp setting with limited ability for structural changes. Specifically, we explore how health promotion activities that help identify target groups for hygiene interventions can play a role in disease prevention. An anonymous survey was conducted at the United Nations Relief and Works Agency Health Clinic in the Kulandia refugee camp to assess the safe water and personal hygiene practices. Demographic and social characteristics, accessible water and personal hygiene characteristics, and gastrointestinal (GI) burden for individuals and their households were assessed. A total of 96 individuals were enrolled; 62 females and 34 males. Approximately 58% of the sample had soap available and washed hands before and after eating and when preparing food. Piped water was the main source of drinking water (62%), while 31% of our sample utilized tanker-trucks. 93% of participants had access to toilet facilities, with 86% of these facilities being private households. 55% practice extra water hygiene measures on their household drinking water source. 51.3% considered vendor cleanliness when they were buying food. 51% had received formal health education. 68.8% had been taught by their parents, but only 55.2% were teaching their children and 15.6% had consistent access to a health professional for hygiene inquiries. Individual variables and hygiene practices associated with lower rates of diarrheal illnesses included having water piped into the home, proper hand washing, adequate soap availability, proper consideration of vendor cleanliness, higher income, levels of education, health hygiene education, and having access to healthcare professions to discuss hygiene related matters. This is

  16. 'Plasma Camp': A Different Approach to Professional Development for Physics Teachers

    Energy Technology Data Exchange (ETDEWEB)

    Andrew Post-Zwicker and Nicholas R. Guilbert

    1998-12-01

    The Plasma Physics and Fusion Energy Institute ('Plasma Camp') was inaugurated in 1998 as a way to address two areas of concern in the professional development of high-school physics teachers: involving teachers in the theory and methods of a current area of research in physics and connecting the research experience back into the classroom. The Institute, run jointly by a scientist and a teacher, immersed high-school teachers from across the country in laboratory investigations and in pedagogical projects for two weeks at Princeton University's Plasma Physics Laboratory. The goals, structure, and initial outcomes of the Institute are discussed.

  17. The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB

    OpenAIRE

    Kandel Eric R

    2012-01-01

    Abstract The analysis of the contributions to synaptic plasticity and memory of cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB has recruited the efforts of many laboratories all over the world. These are six key steps in the molecular biological delineation of short-term memory and its conversion to long-term memory for both implicit (procedural) and explicit (declarative) memory. I here first trace the background for the clinical and behavioral studies of implicit memory that made a molecular biol...

  18. The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB

    Directory of Open Access Journals (Sweden)

    Kandel Eric R

    2012-05-01

    Full Text Available Abstract The analysis of the contributions to synaptic plasticity and memory of cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB has recruited the efforts of many laboratories all over the world. These are six key steps in the molecular biological delineation of short-term memory and its conversion to long-term memory for both implicit (procedural and explicit (declarative memory. I here first trace the background for the clinical and behavioral studies of implicit memory that made a molecular biology of memory storage possible, and then detail the discovery and early history of these six molecular steps and their roles in explicit memory.

  19. Predicting sickness during a 2-week soccer camp at 3600 m (ISA3600)

    OpenAIRE

    Buchheit, Martin; Simpson, Ben M; Schmidt, Walter F; Aughey, Robert J; Soria, Rudy; Hunt, Robert A; Garvican-Lewis, Laura A; Pyne, David B; Gore, Christopher J; Bourdon, Pitre C

    2013-01-01

    Objectives To examine the time course of changes in wellness and health status markers before and after episodes of sickness in young soccer players during a high-altitude training camp (La Paz, 3600 m). Methods Wellness and fatigue were assessed daily on awakening using specifically-designed questionnaires and resting measures of heart rate and heart rate variability. The rating of perceived exertion and heart rate responses to a submaximal run (9 km/h) were also collected during each traini...

  20. Usefulness of training camps at high altitude for well-trained adolescents

    OpenAIRE

    Jiří Suchý; Jakub Opočenský

    2015-01-01

    Objective: Opinions on the suitability of sports training at altitudes of 1800-2200 m above sea level (ASL) for increasing performance in youth are not unanimous. The objective of this study was to test the influence of a ten day altitude training camp on performance in well-trained adolescent cross-country skiers. Methods: A running test of 3 × 2 km (aerobic, anaerobic and critical intensity) was used with a rest interval of 10 minutes. The test was performed 4 times - an initial test at a l...

  1. Extracellular ATP and Dibutyryl cAMP Enhance the Freezability of Rat Epididymal Sperm

    OpenAIRE

    Yamashiro, Hideaki; Toyomizu, Masaaki; Toyama, Natsuki; Aono, Nobuya; Sakurai, Masahiro; HIRADATE, Yuuki; Yokoo, Masaki; Moisyadi, Stefan; Sato, Eimei

    2010-01-01

    We studied the effects of ATP, ionomycin, and dibutyryl cAMP (dbcAMP) on the motility, freezability, and oxygen consumption of rat epididymal sperm. In vitro fertilization and intrauterine insemination were performed by using frozen–thawed rat sperm. Frozen–thawed sperm diluted in raffinose–modified Krebs-Ringer bicarbonate solution–egg yolk extender containing 1.85 mM ATP and 100 μM dbcAMP exhibited considerably higher motility and viability than sperm diluted in dbcAMP-free extender. Additi...

  2. Exploratory Study of Participants' Perceptions of the Benefits of Surf Camps

    OpenAIRE

    Smith, Troy Scott

    2010-01-01

    The purpose of this study was to discuss and validate the benefits of surf camps. Additionally, the results of this study will aid the further research of adolescents achieving higher self-esteem levels, increased positive self-worth, and behavior change through non-traditional sports. The primary research question asked for this study is â How do non-traditional sports, such as surfing, affect self worth, self-esteem, and positive behavior change?â A survey was used to collect data among ...

  3. An assessment of diabetes care in Palestinian refugee camps in Syria

    OpenAIRE

    Alabed, Samer; Guul, Aisha; Crighton, Claire; Alahdab, Fares; Fares, Munes; Morad, Mohammad; Sonbol, Mohamad B; Madmani, Mohammed E; Sasa, Anas; Unwin, Nigel

    2014-01-01

    Background: Palestinian refugees have been a displaced group of people since 1948, many of whom are living in refugee camps in the Middle East. They are entitled to free health care from the United Nations Relief and Work Agency (UNRWA). They show a higher prevalence of diabetes than the population in their host countries in the Middle East. This study examined the realities of care for diabetic patients in UNRWA health clinics in Damascus, Syria. The aim was three-fold: To investigate the le...

  4. The peculiarities of training process creation in bowling in summer camp

    Directory of Open Access Journals (Sweden)

    Fanigina O.U.

    2009-12-01

    Full Text Available Theoretical development of the departmental bowling teaching is presented in a summer health camp. The system takes into account the features of technique of game and mobile games. They determine the level of development of motive qualities and technique of playing bowling. The construction of lesson is examined. A purpose of lesson is strengthening of locomotorium, development of physical qualities, acquaintance with the rules of safety at a game. The system mastering of rational method of management the motions is rotined a player.

  5. La vulnerabilitat de les zones d'interfase urbana i forestal davant els incendis : estudi de cas de l'incendi de Mont-Roig del Camp (Baix Camp)

    OpenAIRE

    Mira i Pou, Núria; Badia i Perpinyà, Anna

    2008-01-01

    L'incendi de Mont-roig del Camp (Baix Camp) del juliol del 2007 va posar en evidència la manca de planificació i prevenció de les zones que se situen a la interfase entre l'urbà i el forestal. L'experiència dels darrers incendis en zones urbanes ha mostrat la vulnerabilitat d'aquestes àrees davant una nova tipologia d'incendis que no presenta les mateixes característiques que els incendis forestals que tots coneixem, i que s'han anomenat incendis d'interfase urbana i forestal. El present arti...

  6. The analysis of functional capacity of people with tetraplegia during the 1st level of the Active Rehabilitation camp.

    Directory of Open Access Journals (Sweden)

    Jozefowsky Peter

    2011-08-01

    Full Text Available The aim of the study was to analyze functional capacity during the 1st level of the Active Rehabilitation camp of people after spinal cord injury (SCI in cervical segment. The individual functional indicators as: self-service, sphincter control, mobility, locomotion and communication have been analyzed. The study included 30 men with SCI in cervical segment and in age of 18-45. The clinimetric scale for functional rating of neurological patients - The Functional Indicator "Repty" was used in the study. The test were conducted twice: immediately before the beginning of the camp and after. An improvement in functional capacity occurred among all respondents during the 1st level of the AR camp. The greatest improvements concerned the mobility and self-service, smaller improvement occurred in locomotion and sphincter control. There was no significant improvement in level of communication.

  7. Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner.

    Science.gov (United States)

    Kottyan, Leah C; Collier, Ann R; Cao, Khanh H; Niese, Kathryn A; Hedgebeth, Megan; Radu, Caius G; Witte, Owen N; Khurana Hershey, Gurjit K; Rothenberg, Marc E; Zimmermann, Nives

    2009-09-24

    The microenvironment of the lung in asthma is acidic, yet the effect of acidity on inflammatory cells has not been well established. We now demonstrate that acidity inhibits eosinophil apoptosis and increases cellular viability in a dose-dependent manner between pH 7.5 and 6.0. Notably, acidity induced eosinophil cyclic adenosine 5'-monophosphate (cAMP) production and enhanced cellular viability in an adenylate cyclase-dependent manner. Furthermore, we identify G protein-coupled receptor 65 (GPR65) as the chief acid-sensing receptor expressed by eosinophils, as GPR65-deficient eosinophils were resistant to acid-induced eosinophil cAMP production and enhanced viability. Notably, GPR65(-/-) mice had attenuated airway eosinophilia and increased apoptosis in 2 distinct models of allergic airway disease. We conclude that eosinophil viability is increased in acidic microenvironments in a cAMP- and GPR65-dependent manner. PMID:19641187

  8. Race in California's prison fire camps for men: prison politics, space, and the racialization of everyday life.

    Science.gov (United States)

    Goodman, Philip

    2014-09-01

    The vast majority of social scientists agree that race is "socially constructed." Yet many scholars of punishment and prisons still treat race as static, self-evident categories. One result is that not enough is known about the production, meanings, and consequences of race as experienced by prisoners and those who guard and manage them. The author's research on California's prison fire camps uncovers the micro-level ways in which race is performed and imbued with meaning; he reveals how racial understandings color people and settings. One puzzle is that prisoners in California's fire camps will fight natural disasters side by side, sharing water and provisions, but separate into racial groups when in the camp itself. In part to answer this (and in part to develop better understandings of race and prisons more generally), the author unpacks the variegated nature of punishment and the spatialization of race and advocates for research that is faithful to the constructivist framework. PMID:25811067

  9. Conditional Allele Mouse Planner (CAMP): software to facilitate the planning and design of breeding strategies involving mice with conditional alleles.

    Science.gov (United States)

    Hoffert, Jason D; Pisitkun, Trairak; Miller, R Lance

    2012-06-01

    Transgenic and conditional knockout mouse models play an important role in biomedical research and their use has grown exponentially in the last 5-10 years. Generating conditional knockouts often requires breeding multiple alleles onto the background of a single mouse or group of mice. Breeding these mice depends on parental genotype, litter size, transmission frequency, and the number of breeding rounds. Therefore, a well planned breeding strategy is critical for keeping costs to a minimum. However, designing a viable breeding strategy can be challenging. With so many different variables this would be an ideal task for a computer program. To facilitate this process, we created a Java-based program called Conditional Allele Mouse Planner (CAMP). CAMP is designed to provide an estimate of the number of breeders, amount of time, and costs associated with generating mice of a particular genotype. We provide a description of CAMP, how to use it, and offer it freely as an application. PMID:21870117

  10. Systems biology investigation of cAMP modulation to increase SMN levels for the treatment of spinal muscular atrophy.

    Directory of Open Access Journals (Sweden)

    Sean G Mack

    Full Text Available Spinal muscular atrophy (SMA, a leading genetic cause of infant death worldwide, is an autosomal recessive disorder caused by the loss of SMN1 (survival motor neuron 1, which encodes the protein SMN. The loss of SMN1 causes a deficiency in SMN protein levels leading to motor neuron cell death in the anterior horn of the spinal cord. SMN2, however, can also produce some functional SMN to partially compensate for loss of SMN1 in SMA suggesting increasing transcription of SMN2 as a potential therapy to treat patients with SMA. A cAMP response element was identified on the SMN2 promoter, implicating cAMP activation as a step in the transcription of SMN2. Therefore, we investigated the effects of modulating the cAMP signaling cascade on SMN production in vitro and in silico. SMA patient fibroblasts were treated with the cAMP signaling modulators rolipram, salbutamol, dbcAMP, epinephrine and forskolin. All of the modulators tested were able to increase gem formation, a marker for SMN protein in the nucleus, in a dose-dependent manner. We then derived two possible mathematical models simulating the regulation of SMN2 expression by cAMP signaling. Both models fit well with our experimental data. In silico treatment of SMA fibroblasts simultaneously with two different cAMP modulators resulted in an additive increase in gem formation. This study shows how a systems biology approach can be used to develop potential therapeutic targets for treating SMA.

  11. Networks of trainees: examining the effects of attending an interdisciplinary research training camp on the careers of new obesity scholars

    Directory of Open Access Journals (Sweden)

    Godley J

    2014-10-01

    Full Text Available Jenny Godley,1 Nicole M Glenn,2 Arya M Sharma,3 John C Spence4 1Department of Sociology, University of Calgary, Calgary, AB, Canada; 2School of Public Health, Université de Montréal, Montreal, QC, Canada; 3Department of Medicine, 4Sedentary Living Laboratory, Faculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada Abstract: Students training in obesity research, prevention, and management face the challenge of developing expertise in their chosen academic field while at the same time recognizing that obesity is a complex issue that requires a multidisciplinary and multisectoral approach. In appreciation of this challenge, the Canadian Obesity Network (CON has run an interdisciplinary summer training camp for graduate students, new career researchers, and clinicians for the past 8 years. This paper evaluates the effects of attending this training camp on trainees' early careers. We use social network analysis to examine the professional connections developed among trainee Canadian obesity researchers who attended this camp over its first 5 years of operation (2006–2010. We examine four relationships (knowing, contacting, and meeting each other, and working together among previous trainees. We assess the presence and diversity of these relationships among trainees across different years and disciplines and find that interdisciplinary contact and working relationships established at the training camp have been maintained over time. In addition, we evaluate the qualitative data on trainees' career trajectories and their assessments of the impact that the camp had on their careers. Many trainees report that camp attendance had a positive impact on their career development, particularly in terms of establishing contacts and professional relationships. Both the quantitative and the qualitative results demonstrate the importance of interdisciplinary training and relationships for career development in the health

  12. Interaction between cAMP and intracellular Ca(2+)-signaling pathways during odor-perception and adaptation in Drosophila.

    Science.gov (United States)

    Murmu, Meena Sriti; Martin, Jean-René

    2016-09-01

    Binding of an odorant to olfactory receptors triggers cascades of second messenger systems in olfactory receptor neurons (ORNs). Biochemical studies indicate that the transduction mechanism at ORNs is mediated by cyclic adenosine monophosphate (cAMP) and/or inositol,1,4,5-triphosphate (InsP3)-signaling pathways in an odorant-dependent manner. However, the interaction between these two second messenger systems during olfactory perception or adaptation processes is much less understood. Here, we used interfering-RNAi to disrupt the level of cAMP alone or in combination with the InsP3-signaling pathway cellular targets, InsP3 receptor (InsP3R) or ryanodine receptor (RyR) in ORNs, and quantify at ORN axon terminals in the antennal lobe, the odor-induced Ca(2+)-response. In-vivo functional bioluminescence Ca(2+)-imaging indicates that a single 5s application of an odor increased Ca(2+)-transients at ORN axon terminals. However, compared to wild-type controls, the magnitude and duration of ORN Ca(2+)-response was significantly diminished in cAMP-defective flies. In a behavioral assay, perception of odorants was defective in flies with a disrupted cAMP level suggesting that the ability of flies to correctly detect an odor depends on cAMP. Simultaneous disruption of cAMP level and InsP3R or RyR further diminished the magnitude and duration of ORN response to odorants and affected the flies' ability to detect an odor. In conclusion, this study provides functional evidence that cAMP and InsP3-signaling pathways act in synergy to mediate odor processing within the ORN axon terminals, which is encoded in the magnitude and duration of ORN response. PMID:27212269

  13. Interpreting performance of mammograms by radiology residents trained in breast imaging: Comparison with radiologists who attend mammography boot camp

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eun Hye [Dept. of Radiology, Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon (Korea, Republic of); Kim, Sung Hun [Dept. of Radiology, Seoul St. Mary' s Hospital, The Catholic University of Korea College of Medicine, Seoul (Korea, Republic of); An, Jin Kyung [Dept. of Radiology, Eulji General Hospital, Eulji University College of Medicine, Seoul (Korea, Republic of); Choi, Seon Hyeong [Dept. of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Kim, Suk Jung [Dept. of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, Busan (Korea, Republic of)

    2014-12-15

    To compare the interpreting performance of mammograms between residents trained in breast imaging and radiologists who attended the mammography boot camp (MBC) suggesting directions for training in breast imaging. We compared the performance of 61 residents trained in breast imaging for more than 2 months at 21 institutions with that of 141 radiologists who attended MBC using the same test case series. We compared mean scores and rates of correct answers between the two groups and examined residents' mean scores varied by institution. Residents' mean score was 60.9 ± 12.2 and radiologists' mean scores were 56.0 ± 12.2 (p = 0.004) and 78.3 ± 9.2 (p < 0.001) before and after camp, respectively. Residents were superior to pre-camp radiologists in interpreting microcalcifications (70.5% vs. 56.4%; p < 0.001) and true-negative cases (71.8% vs. 59.2%; p < 0.001). They were inferior to post-camp radiologists in interpreting mass/asymmetry (56.7% vs. 86.6%; p < 0.001) and microcalcifications (70.5% vs. 90.3%; p < 0.001). The mean score of all institutions except one was 61.8 ± 9.4. Trained residents' interpreting performance of mammograms is superior to that of pre-camp radiologists but inferior to that of post-camp radiologists. Substantial training in interpreting mammograms during residency is suggested.

  14. Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma

    Science.gov (United States)

    Friesen, Claudia; Hormann, Inis; Roscher, Mareike; Fichtner, Iduna; Alt, Andreas; Hilger, Ralf; Debatin, Klaus-Michael; Miltner, Erich

    2014-01-01

    Glioblastoma are the most frequent and malignant human brain tumors, having a very poor prognosis. The enhanced radio- and chemoresistance of glioblastoma and the glioblastoma stem cells might be the main reason why conventional therapies fail. The second messenger cyclic AMP (cAMP) controls cell proliferation, differentiation, and apoptosis. Downregulation of cAMP sensitizes tumor cells for anti-cancer treatment. Opioid receptor agonists triggering opioid receptors can activate inhibitory Gi proteins, which, in turn, block adenylyl cyclase activity reducing cAMP. In this study, we show that downregulation of cAMP by opioid receptor activation improves the effectiveness of anti-cancer drugs in treatment of glioblastoma. The µ-opioid receptor agonist D,L-methadone sensitizes glioblastoma as well as the untreatable glioblastoma stem cells for doxorubicin-induced apoptosis and activation of apoptosis pathways by reversing deficient caspase activation and deficient downregulation of XIAP and Bcl-xL, playing critical roles in glioblastomas’ resistance. Blocking opioid receptors using the opioid receptor antagonist naloxone or increasing intracellular cAMP by 3-isobutyl-1-methylxanthine (IBMX) strongly reduced opioid receptor agonist-induced sensitization for doxorubicin. In addition, the opioid receptor agonist D,L-methadone increased doxorubicin uptake and decreased doxorubicin efflux, whereas doxorubicin increased opioid receptor expression in glioblastomas. Furthermore, opioid receptor activation using D,L-methadone inhibited tumor growth significantly in vivo. Our findings suggest that opioid receptor activation triggering downregulation of cAMP is a promising strategy to inhibit tumor growth and to improve the effectiveness of anti-cancer drugs in treatment of glioblastoma and in killing glioblastoma stem cells. PMID:24626197

  15. [Suitability of spatial pattern of camping sites in Langxiang Natural Reserve, Northeast Chi- na, based on GIS technology].

    Science.gov (United States)

    Yuan, Wei; Zhang, Jie; Tan Ji-qiang; Zhou, Bo; Kang, Rui-cun; Wang, Ai-hong; Liu, Wei; Zhang, Lu

    2015-09-01

    It is an effective way for natural reserves to enhance self-supportive ability and realize sustainable development by developing ecotourism. Taking the experimental zone of Langxiang Natural Reserve in Heilongjiang Province as research object, the forest sub-compartment as research unit, and spatial pattern of environmental suitability of camping sites as research content, an evaluation index system taking natural environment, geographical security, infrastructure and traffic as project levels was built. Delphi and AHP methods were used to determine index weights. A spatial distribution map of camping environmental suitability in Langxiang Natural Reserve was drawn using the GIS spatial information processing technology based on "3S" measurement and the survey data. The results showed that the highest score for quantification of environmental suitability was 90, while the lowest score was 78, and the average value was 83.66 in the 1067 forest sub-compartments for test. The area of forest sub-compartments which were suitable for camping was 1094.44 hm2, being 12.2% of the experimental zone. The forest sub-compartments which had high environmental suitability in the research area were distributed uniformly and centralized with low degree of fragmentation. It was suggested that the contiguous forest sub-compartments with high scores of environmental suitability could be integrated for camping tourism. Due to the high level of environmental suitability for camping, the experimental zone of Langxiang Natural Reserve is suitable for developing camping tourism. Based on "3S" technology, the land use conditions of ecotourism environment of a natural reserve could be evaluated quickly and quantitatively by mathematical model. PMID:26785562

  16. Characterization of a new CAMP factor carried by an integrative and conjugative element in Streptococcus agalactiae and spreading in Streptococci.

    Directory of Open Access Journals (Sweden)

    Sarah Chuzeville

    Full Text Available Genetic exchanges between Streptococci occur frequently and contribute to their genome diversification. Most of sequenced streptococcal genomes carry multiple mobile genetic elements including Integrative and Conjugative Elements (ICEs that play a major role in these horizontal gene transfers. In addition to genes involved in their mobility and regulation, ICEs also carry genes that can confer selective advantages to bacteria. Numerous elements have been described in S. agalactiae especially those integrated at the 3' end of a tRNA(Lys encoding gene. In strain 515 of S. agalactiae, an invasive neonate human pathogen, the ICE (called 515_tRNA(Lys is functional and carries different putative virulence genes including one encoding a putative new CAMP factor in addition to the one previously described. This work demonstrated the functionality of this CAMP factor (CAMP factor II in Lactococcus lactis but also in pathogenic strains of veterinary origin. The search for co-hemolytic factors in a collection of field strains revealed their presence in S. uberis, S. dysgalactiae, but also for the first time in S. equisimilis and S. bovis. Sequencing of these genes revealed the prevalence of a species-specific factor in S. uberis strains (Uberis factor and the presence of a CAMP factor II encoding gene in S. bovis and S. equisimilis. Furthermore, most of the CAMP factor II positive strains also carried an element integrated in the tRNA(Lys gene. This work thus describes a CAMP factor that is carried by a mobile genetic element and has spread to different streptococcal species.

  17. Funktionelle in vitro-Effekte CAMP/CGMP-modulierender Pharmaka am humanen Detrusormuskel

    Directory of Open Access Journals (Sweden)

    Ückert St

    2002-01-01

    Full Text Available Die zyklischen Nukleotidmonophosphate cAMP und cGMP regulieren als intrazelluläre Second Messenger zahlreiche Gewebe- und Organfunktionen. cAMP und cGMP werden von zellulären Adenylat- und Guanylatzyklasen synthetisiert und von Phosphodiesterasen degradiert, die somit Schlüsselenzyme im Prozeß der Tonusregulation glatter Muskulatur sind. Die Markteinführung des PDE5-Inhibitors Sildenafil (Viagra hat dem Konzept der PDE-Inhibition auch in der Urologie breite Akzeptanz verschafft. Eigene Arbeiten der vergangenen Jahre beschreiben die Präsenz der PDE-Isoenzyme 1, 2, 3, 4 und 5 in der Muskulatur des humanen Detrusors und zeigen das klinische Potential des PDE1-Inhibitors Vinpocetin in der Behandlung der motorischen Dranginkontinenz. Mit dem Ziel der Charakterisierung geeigneter Substanzen für die Pharmakotherapie der Detrusorhyperaktivität haben wir die in vitro-Effekte neuer, selektiver Inhibitoren der PDE des Typs 2, 3 und 5 auf isolierte humane Detrusormuskulatur untersucht und mit denen des Diterpens Forskolin (Aktivator der Adenylatzyklase und der Stickoxid (NO-Donatoren Dihydropyridin (DHP und Na+Nitroprussid (NNP verglichen.

  18. Training Diaries during Altitude Training Camp in Two Olympic Champions: An Observational Case Study

    Directory of Open Access Journals (Sweden)

    Lorenzo Pugliese, Fabio R. Serpiello, Grégoire P. Millet, Antonio La Torre

    2014-09-01

    Full Text Available Traditionally, Live High-Train High (LHTH interventions were adopted when athletes trained and lived at altitude to try maximising the benefits offered by hypoxic exposure and improving sea level performance. Nevertheless, scientific research has proposed that the possible benefits of hypoxia would be offset by the inability to maintain high training intensity at altitude. However, elite athletes have been rarely recruited as an experimental sample, and training intensity has almost never been monitored during altitude research. This case study is an attempt to provide a practical example of successful LHTH interventions in two Olympic gold medal athletes. Training diaries were collected and total training volumes, volumes at different intensities, and sea level performance recorded before, during and after a 3-week LHTH camp. Both athletes successfully completed the LHTH camp (2090 m maintaining similar absolute training intensity and training volume at high-intensity (> 91% of race pace compared to sea level. After the LHTH intervention both athletes obtained enhancements in performance and they won an Olympic gold medal. In our opinion, LHTH interventions can be used as a simple, yet effective, method to maintain absolute, and improve relative training intensity in elite endurance athletes.

  19. Engaging undergraduates in interdisciplinary science during a pre-orientation camp

    Science.gov (United States)

    Heath, Jennifer; Reinke, Catherine; Crosser, Michael; Kruchten, Anne

    2015-03-01

    The Interdisciplinary First-Year Orientation Camp for Undergraduate Sciences (iFOCUS) was created three years ago at Linfield College. Foremost, we looked to create a supportive community to enhance the recruitment, retention, and success of science students--all students, and especially students from non-traditional backgrounds. We saw the close knit community of athletes that came together during pre-orientation practices. Could a community of science students come together with similar enthusiasm and energy? And, we were also looking for a way to expose first year students to a scientific way of thinking, embracing open-ended, research oriented, interdisciplinary problems. After the camp is over, iFOCUS students frequently join faculty research laboratories, they draw in additional students to ongoing learning communities, and a seminar series brings in outside speakers. I will discuss the program initiatives and outcomes, which have been especially useful to physics-where building an enthusiastic peer network and addressing misconceptions about science in general, and physics in particular, seem to be especially useful. Supported by the Hearst Foundation.

  20. Cl- transport pathways regulated by Ca++, cAMP, and pH in human fibroblasts

    International Nuclear Information System (INIS)

    Under basal conditions Cl- efflux from human fibroblasts occurs with a rate constant of permeability of 0.08 min-1. 50% of the basal efflux is due to Cl-/anion exchange and is DIDS inhibitable, 25% is due to Na+/K+/Cl- cotransport and is furosemide inhibitable, and 20% is due to an electrically conductive pathway. Increasing intracellular Ca++ with A23187 stimulates Cl- efflux by 30%. This increase appears to occur entirely via an electrically conducting pathway, but unlike basal Cl- conductance, it is DIDS sensitive. Exposure of the cells to dibutyryl cAMP stimulates Cl- efflux by 15%. They do not yet know whether the cAMP stimulated pathway is electrically conductive, but the stimulation is additive with that caused by elevated Ca++ suggesting that different pathways are activated. Elevation of intracellular pH by any of several standard methods increases Cl- efflux by as much as 700%. The pH effect appears to be mediated by a Cl-/anion exchange pathway since it is DIDS sensitive and electroneutral. Previous work from this laboratory describing a transient rapid efflux of Cl- followed by a slower efflux phase can now be explained as the result of a transient alkalinization of cells rather than as 2 subcellular Cl- compartments. This alkalinization occurs when cells are transferred from a 5% CO2 atmosphere during 36Cl- load to ambient CO2 for efflux

  1. Combined use of SAR and optical data for environmental assessments around refugee camps in semiarid landscapes

    Science.gov (United States)

    Braun, A.; Hochschild, V.

    2015-04-01

    Over 15 million people were officially considered as refugees in the year 2012 and another 28 million as internally displaced people (IDPs). Natural disasters, climatic and environmental changes, violent regional conflicts and population growth force people to migrate in all parts of this world. This trend is likely to continue in the near future, as political instabilities increase and land degradation progresses. EO4HumEn aims at developing operational services to support humanitarian operations during crisis situations by means of dedicated geo-spatial information products derived from Earth observation and GIS data. The goal is to develop robust, automated methods of image analysis routines for population estimation, identification of potential groundwater extraction sites and monitoring the environmental impact of refugee/IDP camps. This study investigates the combination of satellite SAR data with optical sensors and elevation information for the assessment of the environmental conditions around refugee camps. In order to estimate their impact on land degradation, land cover classifications are required which target dynamic landscapes. We performed a land use / land cover classification based on a random forest algorithm and 39 input prediction rasters based on Landsat 8 data and additional layers generated from radar texture and elevation information. The overall accuracy was 92.9 %, while optical data had the highest impact on the final classification. By analysing all combinations of the three input datasets we additionally estimated their impact on single classification outcomes and land cover classes.

  2. The Effect of an Altitude Training Camp on Swimming Start Time and Loaded Squat Jump Performance.

    Science.gov (United States)

    García-Ramos, Amador; Štirn, Igor; Padial, Paulino; Argüelles-Cienfuegos, Javier; De la Fuente, Blanca; Calderón, Carmen; Bonitch-Góngora, Juan; Tomazin, Katja; Strumbelj, Boro; Strojnik, Vojko; Feriche, Belén

    2016-01-01

    This study evaluated the influence of an altitude training (AT) camp on swimming start time and loaded squat jump performance. To accomplish this goal, 13 international swimmers (8 women, 5 men) were allocated to both the control (Sea Level Training, SLT) and experimental conditions (AT, 2320 m above sea level) that were separated by a one year period. All tests (15 m freestyle swimming start and loaded squat jumps with additional loads of 25%, 50%, 75%, and 100% of swimmers' body weight) were performed before and after a concurrent 3-week strength and endurance training program prescribed by the national coach. Following the SLT camp, significant impairments in swimming start times to 10 (+3.1%) and 15 m (+4.0%) were observed (P 0.05). Trivial changes in peak velocity were obtained during the loaded squat jump after both training periods (effect sizes: < 0.20). Based on these results we can conclude that a traditional training high-living high strategy concurrent training of 3 weeks does not adversely affect swimming start time and loaded squat jump performance in high level swimmers, but further studies are necessary to assess the effectiveness of power-oriented resistance training in the development of explosive actions. PMID:27467760

  3. Cross-talk between signaling pathways can generate robust oscillations in calcium and cAMP.

    Directory of Open Access Journals (Sweden)

    Fernando Siso-Nadal

    Full Text Available BACKGROUND: To control and manipulate cellular signaling, we need to understand cellular strategies for information transfer, integration, and decision-making. A key feature of signal transduction is the generation of only a few intracellular messengers by many extracellular stimuli. METHODOLOGY/PRINCIPAL FINDINGS: Here we model molecular cross-talk between two classic second messengers, cyclic AMP (cAMP and calcium, and show that the dynamical complexity of the response of both messengers increases substantially through their interaction. In our model of a non-excitable cell, both cAMP and calcium concentrations can oscillate. If mutually inhibitory, cross-talk between the two second messengers can increase the range of agonist concentrations for which oscillations occur. If mutually activating, cross-talk decreases the oscillation range, but can generate 'bursting' oscillations of calcium and may enable better filtering of noise. CONCLUSION: We postulate that this increased dynamical complexity allows the cell to encode more information, particularly if both second messengers encode signals. In their native environments, it is unlikely that cells are exposed to one stimulus at a time, and cross-talk may help generate sufficiently complex responses to allow the cell to discriminate between different combinations and concentrations of extracellular agonists.

  4. cAMP receptor protein (CRP) downregulates Klebsiella pneumoniae nif promoters in Escherichia coli

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In enteric bacteria, in response to the PTS system, the cAMP receptor protein (CRP) mediates the glucose effect, via regulating s70-dependent catabolic genes at transcriptional level. In this study, it is observed that the nitrogen fixation capacity of Klebsiella pneumoniae varies strongly when cells are grown on different carbohydrates, and this carbon effect occurs at the level of nif gene expression. Here we show that CRP can repress s54-dependent nif promoters (nifB, nifE, nifF, nifH, nifJ, nifLA and nifU), in a cAMP dependent fashion, in closed related E. coli background. Sequence analysis of these nif promoters indicates that there is no direct correlation between the fold of CRP-cAMP-mediated inhibition and the upstream cis elements at the promoters. In addition, the crp gene of K. pneumoniae has been isolated and sequenced, which is structural and functional highly homologous to that of E. coli. This suggests that CRP-cAMP-mediated inhibition on the nif promoters could be the reason for carbon effect on nitrogen fixation and thus has its physiological significance. A novel regulatory linkage between carbon metabolism and nitrogen fixation is proposed.

  5. Quality of life of Syrian refugees living in camps in the Kurdistan Region of Iraq

    Directory of Open Access Journals (Sweden)

    Izaddin A. Aziz

    2014-11-01

    Full Text Available The current study explores the perceived quality of life of Syrian refugees who have entered the Kurdistan Region of Iraq. Two hundred and seventy participants residing in refugee camps in the Erbil region in Kurdistan completed the WHOQOL-BREF, which measures Quality of Life (QOL within four domains; physical, psychological, social relationships and environment. Syrian refugees in Kurdistan scored significantly lower for general population norms on physical health, psychological and environment QOL, and score significantly lower for physical health and psychological QOL for refugees in the Gaza strip. However, respondents in the current sample scored significantly higher on environment QOL compared to refugees in the Gaza strip, and significantly higher on all the QOL domains than those reported for refugees in West Africa. Finally, Syrian refugees in Kurdistan scored significantly higher than general population norms for social relationships QOL. The current findings provide the first report of QOL domain scores among Syrian refugees in the Kurdistan camps and suggest that social relationships and environmental QOL circumstances are relatively satisfactory, and that further investigation might be focused on physical and psychological QOL.

  6. Demonstration of a 1 MWe biomass power plant at USMC Base Camp Lejeune

    International Nuclear Information System (INIS)

    A biomass energy conversion project is being sponsored by the U.S. Environmental Protection Agency (EPA) to demonstrate an environmentally and economically sound electrical power option for government installations, industrial sites, rural cooperatives, small municipalities, and developing countries. Under a cooperative agreement with EPA, Research Triangle Institute is initiating operation of the Camp Lejeune Energy from Wood (CLEW) biomass plant. Wood gasification combined with internal combustion engines was chosen because of (1) recent improvements in gas cleaning, (2) simple, economical operation for units less than 10 MW, and (3) the option of a clean, cheap fuel for the many existing facilities generating expensive electricity from petroleum fuels with reciprocating engines. The plant incorporates a downdraft, moving bed gasifier utilizing hogged waste wood from the Marine Corps Base at Camp Lejeune, NC. A moving bed bulk wood dryer and both spark ignition and diesel engines are included. Unique process design features are briefly described relative to the gasifier, wood drying, tar separation, and process control. A test plan for process optimization and demonstration of reliability, economics, and environmental impact is outlined. (author)

  7. Notes from the Field: Tickborne Relapsing Fever Outbreak at an Outdoor Education Camp - Arizona, 2014.

    Science.gov (United States)

    Jones, Jefferson M; Schumacher, Mare; Peoples, Marie; Souders, Nina; Horn, Kimberly; Fox, Lisa; Scott, Michele; Brady, Shane; Weiss, Joli; Komatsu, Ken; Nieto, Nathan

    2015-06-19

    Tickborne relapsing fever (TBRF) is a bacterial infection characterized by recurring episodes of fever, headache, muscle and joint aches, and nausea. In North America, TBRF primarily is caused by Borrelia hermsii spirochetes transmitted by Ornithodoros hermsii ticks. Once infected, these soft ticks are infectious for life and transmit the spirochete to sleeping humans quickly (possibly within 30 seconds) during short feeds (15-90 minutes). On August 10, 2014, the Coconino County Public Health Services District in Arizona was notified by a local hospital that five high school students who attended the same outdoor education camp had been hospitalized with fever, headache, and myalgias. Hantavirus infection initially was suspected because of reported exposure to rodent droppings, but after detecting spirochetes on peripheral blood smears from all five hospitalized students, TBRF was diagnosed. The camp was instructed to close immediately, and the health department, in collaboration with local university experts, investigated to identify additional cases, determine the cause, and prevent further infections. A total of 11 cases (six confirmed and five probable) were identified. PMID:26086637

  8. Malaria in Kakuma refugee camp, Turkana, Kenya: facilitation of Anopheles arabiensis vector populations by installed water distribution and catchment systems

    Directory of Open Access Journals (Sweden)

    Cetron Martin S

    2011-06-01

    Full Text Available Abstract Background Malaria is a major health concern for displaced persons occupying refugee camps in sub-Saharan Africa, yet there is little information on the incidence of infection and nature of transmission in these settings. Kakuma Refugee Camp, located in a dry area of north-western Kenya, has hosted ca. 60,000 to 90,000 refugees since 1992, primarily from Sudan and Somalia. The purpose of this study was to investigate malaria prevalence and attack rate and sources of Anopheles vectors in Kakuma refugee camp, in 2005-2006, after a malaria epidemic was observed by staff at camp clinics. Methods Malaria prevalence and attack rate was estimated from cases of fever presenting to camp clinics and the hospital in August 2005, using rapid diagnostic tests and microscopy of blood smears. Larval habitats of vectors were sampled and mapped. Houses were sampled for adult vectors using the pyrethrum knockdown spray method, and mapped. Vectors were identified to species level and their infection with Plasmodium falciparum determined. Results Prevalence of febrile illness with P. falciparum was highest among the 5 to 17 year olds (62.4% while malaria attack rate was highest among the two to 4 year olds (5.2/1,000/day. Infected individuals were spatially concentrated in three of the 11 residential zones of the camp. The indoor densities of Anopheles arabiensis, the sole malaria vector, were similar during the wet and dry seasons, but were distributed in an aggregated fashion and predominantly in the same zones where malaria attack rates were high. Larval habitats and larval populations were also concentrated in these zones. Larval habitats were man-made pits of water associated with tap-stands installed as the water delivery system to residents with year round availability in the camp. Three percent of A. arabiensis adult females were infected with P. falciparum sporozoites in the rainy season. Conclusions Malaria in Kakuma refugee camp was due mainly

  9. Crp of Streptomyces Coelicolor Is the Third Transcription Factor of the Large Crp-Fnr Superfamily Able to Bind Camp

    OpenAIRE

    Derouaux, Adeline; Dehareng, Dominique; Lecocq, Elke; Halici, Serkan; Nothaft, Harald; Giannotta, Fabrizio; Moutzourelis, Georgios; Dusart, Jean; Devreese, Bart; Titgemeyer, Fritz; Van Beeumen, Jozef; Rigali, Sébastien

    2004-01-01

    The chromosomal inactivation of the unique transcription factor of Streptomyces coelicolor that displays a cyclic-nucleotide-binding domain, Crp(Sco), led to a germination-defective phenotype similar to the mutant of the adenylate cyclase gene (cya) unable to produce cAMP. By means of cAMP affinity chromatography we demonstrate the specific cAMP-binding ability of Crp(Sco), which definitely demonstrate that a Cya/cAMP/Crp system is used to trigger germination in S. coelicolor. However, electr...

  10. A new cAMP response element in the transcribed region of the human c-fos gene.

    OpenAIRE

    Härtig, E; Loncarević, I F; Büscher, M.; Herrlich, P; Rahmsdorf, H J

    1991-01-01

    In NIH 3T3 cells the c-fos gene is induced rapidly and transiently by cAMP. As shown by the analysis of 3T3 cells stably transfected with promoter mutants of the human c-fos gene this induction does not depend on the dyad symmetry element (position -320 to -300), but involves at least two other non-related sites: an element located around position -60 resembling the cAMP response element of the fibronectin and somatostatin genes (which has been described before), and an element located betwee...

  11. ["With paper, pencil, and slide rule." Cancer specialist Hermann Druckrey in internment camp Hammelburg (1946-1947)].

    Science.gov (United States)

    Wunderlich, Volker

    2008-01-01

    After World War II, Hermann Druckrey and Karl Küpfmüller spent many months in allied internment camps in Germany. In camp Hammelburg, the scholars formed a research collaboration which resulted in two very important publications. Druckrey informed Adolf Butenandt about the co-operation in personal letters which have recently become accessible. Through this new source, the origins of the Druckrey-Küpfmüller papers of 1948-1949 have been confirmed and some further details have been added. PMID:19137980

  12. cAMP dependent and independent regulation of thyroglobulin synthesis by two clones of the OVNIS 6H thyroid cell line.

    Science.gov (United States)

    Aouani, A; Hovsépian, S; Fayet, G

    1987-07-01

    The hormonal regulation of thyroglobulin synthesis has been studied using two independent clones of the OVNIS 6H cell line. Insulin, hydrocortisone and TSH were able to stimulate thyroglobulin synthesis, whereas transferrin, somatostatin and glycyl-histidyl-lysine were without effect. Insulin stimulated thyroglobulin synthesis without affecting cAMP production. Hydrocortisone, when combined with insulin was a stimulator too; this stimulation was not accompanied by an increase in cAMP. TSH alone was unable to stimulate either cAMP or thyroglobulin synthesis. The stimulatory effect of TSH on thyroglobulin synthesis took place only when combined with insulin or insulin plus hydrocortisone, and was mediated by cAMP. Consequently, insulin and hydrocortisone stimulated thyroglobulin synthesis by cAMP-independent mechanisms, whereas TSH acted via the cAMP system. Forskolin mimicked TSH effects on cAMP and thyroglobulin synthesis. Calf serum inhibited cAMP and thyroglobulin production. Optimal cAMP and thyroglobulin synthesis as well as TSH responsiveness were obtained in serum-free medium supplemented with 5 micrograms/ml insulin, 100 nM hydrocortisone and 1 mU/ml TSH. PMID:3040495

  13. A cAMP Biosensor-Based High-Throughput Screening Assay for Identification of Gs-Coupled GPCR Ligands and Phosphodiesterase Inhibitors

    DEFF Research Database (Denmark)

    Vedel, Line; Bräuner-Osborne, Hans; Mathiesen, Jesper Mosolff

    2015-01-01

    Cyclic adenosine 3',5'-monophosphate (cAMP) is an important second messenger, and quantification of intracellular cAMP levels is essential in studies of G protein-coupled receptors (GPCRs). The intracellular cAMP levels are regulated by the adenylate cyclase (AC) upon activation of either Gs- or Gi......-coupled GPCRs, which leads to increased or decreased cAMP levels, respectively. Here we describe a real-time Förster resonance energy transfer (FRET)-based cAMP high-throughput screening (HTS) assay for identification and characterization of Gs-coupled GPCR ligands and phosphodiesterase (PDE) inhibitors...... resulted in prolonged signaling and enabled detection of weak partial agonists and/or ligands with low potency, which is highly advantageous in large HTS settings and hit identification. In addition, the assay enabled detection of β2AR inverse agonists and PDE inhibitors. High signal-to-noise ratios were...

  14. Enhanced killing effects of caffein post-treatment in ultraviolet-light irradiated mouse lymphoma cells: is cAMP a mediator of the effects?

    Science.gov (United States)

    Kuwashima, Y; Miyachi, Y; Okada, S; Iio, M; Nakamura, N

    1983-01-01

    Effects of post-treatment with caffein, cyclic adenosine 3':5'-monophosphate (cAMP) and N6, O2-dibutyryl cAMP (dbcAMP) were investigated in ultraviolet light (UV)-irradiated mouse lymphoma L5178Y cells. Under conditions where UV or each chemical alone caused only slight cytotoxic effects, caffein post-treatment showed clear synergistic effects in cell killing but not for cAMP or dbcAMP. Subsequently, a mutant clone resistant to cAMP was isolated. This mutant was supposed to be deficient in cAMP-mediated cellular functions. Using the mutant cells, it was found that these cells were also sensitive to caffein post-treatment as wild cells after UV-irradiation. The results imply that the enhanced killing effects by caffein post-treatment in UV irradiated cells is not mediated by cAMP. PMID:6093199

  15. Long-term Monitoring of the Environmental Impact of a Refugee Camp Based on Landsat Time Series: The Example of Deforestation and Reforestation During the whole Lifespan of the Camp Lukole, Tanzania. GI_Forum|GI_Forum 2015 – Geospatial Minds for Society|

    OpenAIRE

    TIEDE Dirk; Lüthje, Fritjof; Langer, Sebastian

    2016-01-01

    This study deals with the long-term monitoring of the environmental impact of the refugee camp Lukole, Tanzania. Based on high resolution (HR) satellite time series of different Landsat sensors, the whole lifespan of the camp is covered, starting before the camp was established (1994) until seven years after the dismantling (2015). A fully automated preclassification approach for different Landsat sensors was applied, and the results were integrated into a post-classification object-specific ...

  16. Intimate partner physical violence among women in Shimelba refugee camp, northern Ethiopia

    Directory of Open Access Journals (Sweden)

    Feseha Girmatsion

    2012-02-01

    Full Text Available Abstract Background Domestic violence has unwanted effects on the physical and psychological well-being of women, which have been recognized globally as an important public health problem. Violence perpetrated by intimate partner is one form of domestic violence, a serious human rights abuse and a public health issue, among refugees owing to its substantial consequences for women's physical, mental and reproductive health problems. Because the incidents are under-reported, the true scale of the problem is unknown and unexamined among refugee women in Ethiopia. Thus, this study aim to assess the magnitude of intimate partner physical violence and associated factors among women in Shimelba refugee camp, Northern Ethiopia. Methods A community-based cross-sectional study was conducted among a sample of 422 refugee women from March to April 2011. A simple random sampling method was used to select the study subjects from seven zones of the refugee camp. Census was done to identify all households with women having an intimate partner. A pre-tested interviewer guided structured questionnaire was used for data collection. Data were entered, cleaned and analyzed using SPSS software version 16.0. Descriptive, bivariate and multivariate logistic regression analyses were done where applicable. A p-value less than 0.05 with 95% CI were set and used as a cut-off point to examine the statistical association between the explanatory and outcome variables. Results The prevalence of physical violence in the last 12 months and lifetime were 107(25.5% and 131(31.0% respectively. The commonest forms of physical violence reported included slapping 101(61.6% and throwing objects 32(19.5%. Significant risk factors associated with experiencing physical violence were being a farmer (AOR = 3.0[95%CI: 1.7, 5.5], knowing women in neighborhood whose husband to beat them (AOR = 1.87[95%CI: 1.0, 3.5], being a Muslim (AOR = 2.4 [95%C.I: 1.107, 5.5], and having a drunkard partner

  17. Relationship Between Vertical Jump Height and Swimming Start Performance Before and After an Altitude Training Camp.

    Science.gov (United States)

    García-Ramos, Amador; Padial, Paulino; de la Fuente, Blanca; Argüelles-Cienfuegos, Javier; Bonitch-Góngora, Juan; Feriche, Belén

    2016-06-01

    García-Ramos, A, Padial, P, de la Fuente, B, Argüelles-Cienfuegos, J, Bonitch-Góngora, J, and Feriche, B. Relationship between vertical jump height and swimming start performance before and after an altitude training camp. J Strength Cond Res 30(6): 1638-1645, 2016-This study aimed (a) to analyze the development in the squat jump height and swimming start performance after an altitude training camp, (b) to correlate the jump height and swimming start performance before and after the altitude training period, and (c) to correlate the percent change in the squat jump height with the percent change in swimming start performance. Fifteen elite male swimmers from the Spanish Junior National Team (17.1 ± 0.8 years) were tested before and after a 17-day training camp at moderate altitude. The height reached in the squat jump exercise with additional loads of 0, 25, 50, 75, and 100% of swimmers' pretest body weight and swimming start performance (time to 5, 10, and 15 m) were the dependent variables analyzed. Significant increases in the jump height (p ≤ 0.05; effect size [ES]: 0.35-0.48) and swimming start performance (p < 0.01; ES: 0.48-0.52) after the training period were observed. The start time had similar correlations with the jump height before training (r = -0.56 to -0.77) and after training (r = -0.50 to -0.71). The change in the squat jump height was inversely correlated with the change in the start time at 5 m (r = -0.47), 10 m (r = -0.73), and 15 m (r = -0.62). These results suggest that altitude training can be suitable to enhance explosive performance. The correlations obtained between the squat jump height and start time in the raw and change scores confirm the relevance of having high levels of lower-body muscular power to optimize swimming start performance. PMID:26473522

  18. Ammonia differentially suppresses the cAMP chemotaxis of anterior-like cells and prestalk cells in Dictyostelium discoideum

    Indian Academy of Sciences (India)

    Ira N Feit; Erika J Medynski; Michael J Rothrock

    2001-06-01

    A drop assay for chemotaxis to cAMP confirms that both anterior-like cells (ALC) and prestalk cells (pst cells) respond to cAMP gradients. We present evidence that the chemotactic response of both ALC and pst cells is suppressed by ammonia, but a higher concentration of ammonia is required to suppress the response in pst cells. ALC show a chemotactic response to cAMP when moving on a substratum of prespore cells in isolated slug posteriors incubated under oxygen. ALC chemotaxis on a prespore cell substratum is suppressed by the same concentration of ammonia that suppresses ALC chemotaxis on the agar substratum in drop assays. Chemotaxis suppression is mediated by the unprotonated (NH3) species of ammonia. The observed suppression, by ammonia, of ALC chemotaxis to cAMP supports our earlier hypothesis that ammonia is the tip-produced suppressor of such chemotaxis. We discuss implications of ammonia sensitivity of pst cells and ALC with regard to the movement and localization of ALC and pst cells in the slug and to the roles played by ALC in fruiting body formation. In addition, we suggest that a progressive decrease in sensitivity to ammonia is an important part of the maturation of ALC into pst cells.

  19. Effects of low dose radiation on cAMP ,cGMP and Fos protein expressions in mouse hypothalamus

    International Nuclear Information System (INIS)

    Objective: In the present study the authors observed the effects of low dose radiation (LDR) on cAMP, cGMP and Fos expressions in mouse hypothalamus. Methods: The changes of cAMP and cGMP contents as well as Fos protein expression in hypothalamus were determined using competitive protein binding assay, radioimmunoassay and immuno-histochemistry, respectively. Results: The cAMP content in the hypothalamus increased rapidly after irradiation with 75 mGy X-rays. It reached its peak value at 15 min, and then returned to nearly normal value at 1 h, followed by small fluctuations. The changes of cGMP content were basically opposite to those of cAMP. The Fos protein was positive in a variety of neurons of hypothalamus after irradiation, and it reached the peak value at 8 h. Then it gradually returned to the control level 48 h after irradiation. Conclusion: These findings suggest that LDR could influence the neuronal signal transduction in mouse hypothalamus with modulating functions on the immune system

  20. Activation of the cAMP Pathway Induces RACK1-Dependent Binding of β-Actin to BDNF Promoter

    Science.gov (United States)

    Neasta, Jeremie; Fiorenza, Anna; He, Dao-Yao; Phamluong, Khanhky; Kiely, Patrick A.; Ron, Dorit

    2016-01-01

    RACK1 is a scaffolding protein that contributes to the specificity and propagation of several signaling cascades including the cAMP pathway. As such, RACK1 participates in numerous cellular functions ranging from cell migration and morphology to gene transcription. To obtain further insights on the mechanisms whereby RACK1 regulates cAMP-dependent processes, we set out to identify new binding partners of RACK1 during activation of the cAMP signaling using a proteomics strategy. We identified β-actin as a direct RACK1 binding partner and found that the association between β-actin and RACK1 is increased in response to the activation of the cAMP pathway. Furthermore, we show that cAMP-dependent increase in BDNF expression requires filamentous actin. We further report that β-actin associates with the BDNF promoter IV upon the activation of the cAMP pathway and present data to suggest that the association of β-actin with BDNF promoter IV is RACK1-dependent. Taken together, our data suggest that β-actin is a new RACK1 binding partner and that the RACK1 and β-actin association participate in the cAMP-dependent regulation of BDNF transcription. PMID:27505161

  1. Impact of drug awareness and treatment camps on attendance at a community outreach de-addiction clinic

    Directory of Open Access Journals (Sweden)

    Om Prakash Giri

    2015-01-01

    Full Text Available Background: Substance misuse is an increasing problem in urban and rural India. The utility of community-based interventions and preventive strategies are increasingly emphasized in this context. The drug de-addiction and treatment center, Department of Psychiatry, Postgraduate Institute of Medical Education and Research, has been running a drug de-addiction and treatment clinic at Kharar Civil Hospital, Kharar, District Mohali, Punjab, since 1998. As part of an effort to enhance this community outreach program, community-based drug awareness and treatment camps have been organized since March 2004 in villages in and around Tehsil Kharar of Mohali. Aim: To study the impact of the drug awareness and treatment camps on the attendance of patients at the community outreach drug de-addiction and treatment clinic at Kharar Civil Hospital. Methods: Sociodemographic and clinical variables, including treatment outcome-related variables, of patients attending the clinic at Kharar Civil Hospital, before and after the camps were compared. Discussion and Conclusion: The study showed a positive impact on drug awareness and treatment camps held in the community on outpatient attendance at a community outreach clinic, with attendance increasing more than 1.8 times.

  2. A residential summer camp can reduce body fat and improve health-related quality of life in obese children

    Science.gov (United States)

    In an earlier report, we showed that a 2-week, residential summer camp (Kamp K'aana) led to improved body weight, body mass index, body mass index z score, and self-esteem among obese children. To assess whether improvements in body weight and self-esteem translate into improvement in body fat and w...

  3. Native American Ethnicity and Childhood Maltreatment as Variables in Perceptions and Adjustments to Boot Camp vs. "Traditional" Correctional Settings

    Science.gov (United States)

    Gover, Angela R.

    2005-01-01

    A sample of 302 juveniles confined in two separate correctional facilities in a Western plains state was assessed to examine the relationship between child maltreatment and other delinquency risk factors, and Native American ethnicity on perceptions of the institutional environments and psychological adjustment in a boot camp and traditional…

  4. c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements

    Energy Technology Data Exchange (ETDEWEB)

    Inagaki, Nobuya; Seino, Yutaka; Imura, Hiroo (Kyoto Univ. (Japan)); Maekawa, Toshio; Sudo, Tatsuhiko; Ishii, Shunsuke (Inst. of Physical and Chemical Research (RIKEN), Tsukuba (Japan))

    1992-02-01

    Glucose is known to increase the cAMP concentration in pancreatic {beta} cells. To determine the mechanism by which cAMP augments insulin gene expression, the authors first identified the cAMP response elements (CREs) of human insulin gene. In DNase I footprint analysis, the bacterially synthesized CRE-binding protein, CRE-BP1, protected four sites: two sites in the region upstream from the insulin core promoter, one site in the first exon, and one site in the first intron. To examine the roles of those four sites, they constructed a series of DNA plasmids in which the wild-type and mutant insulin promoters were linked to the chloramphenicol acetyltransferase gene. Studies of the transcriptional activity of these plasmids after transfection into hamster insulinoma (HIT) cells showed that these four sites contributed additively to the cAMP inducibility of the insulin promoter. Surprisingly, the c-jun protooncogene product (c-Jun) repressed the cAMP-induced activity of the insulin promoter in a cotransfection assay with the c-Jun expression plasmic. Northern blot analysis demonstrated that the level of c-jun mRNA was dramatically increased by glucose deprivation in HIT cells. These results suggest that glucose deprivation in HIT cells. These results suggest that glucose may regulate expression of the human insulin gene through multiple CREs and c-Jun.

  5. Radiometric survey in the sites of Regional office in Fortaleza, research gallery and camp in Itataia, CE (Brazil)

    International Nuclear Information System (INIS)

    The radiometric survey in Regional officer sites in Fortaleza, Brazil, research gallery and camp in Itataia is presented. The measurings to be done, the instrumentation used and results obtained are described as well as the conclusions and recommendations. (C.M.)

  6. Trauma Healing in Refugee Camps in Guinea: A Psychosocial Program for Liberian and Sierra Leonean Survivors of Torture and War

    Science.gov (United States)

    Stepakoff, Shanee; Hubbard, Jon; Katoh, Maki; Falk, Erika; Mikulu, Jean-Baptiste; Nkhoma, Potiphar; Omagwa, Yuvenalis

    2006-01-01

    From 1999 to 2005, the Minneapolis-based Center for Victims of Torture (CVT) served Liberian and Sierra Leonean survivors of torture and war living in the refugee camps of Guinea. A psychosocial program was developed with 3 main goals: (1) to provide mental health care; (2) to train local refugee counselors; and (3) to raise community awareness…

  7. Requiem for a CAMP: the life and death of a domestic U.S. drug war institution.

    Science.gov (United States)

    Corva, Dominic

    2014-01-01

    The life and death of California's Campaign Against Marijuana Planting (CAMP, 1983-2012) offers a unique analytical window into the time and space of the U.S. war on drugs in a global context. This paper draws on CAMP report archives, ethnographic interviews, and secondary data sources to locate the significance of CAMP, its demise, and enduring legacy for the political economy of domestic illicit cannabis production in southern Humboldt County, where it was initially focused. I first introduce the economic geography of cannabis production in southern Humboldt County and California. In the first part of the paper, using theoretical frameworks from Critical Geopolitics and International Relations, I examine the geo-politics of CAMP's emergence. In the second part of the paper, I examine industrial reterritorialization associated with its geographies of enforcement over time. I conclude by discussing the eclipse of its foundational logic-and-practice (policing the "Emerald Triangle") by new political and economic geographies of power. PMID:23561719

  8. A Randomized Evaluation of the Maryland Correctional Boot Camp for Adults: Effects on Offender Antisocial Attitudes and Cognitions

    Science.gov (United States)

    Mitchell, Ojmarrh; MacKenzie, Doris L.; Perez, Deanna M.

    2005-01-01

    This research addresses the question: Does the military atmosphere of a treatment-oriented boot camp lead to greater reductions in antisocial attitudes and cognitions than a standard correctional facility that is also treatment-oriented? A self-report measure of antisocial attitudes and cognitions was collected from 118 inmates randomly assigned…

  9. At-Risk Boys' Social Self-Efficacy and Physical Activity Self-Efficacy in a Summer Sports Camp

    Science.gov (United States)

    Su, Xiaoxia; Xiang, Ping; McBride, Ron E.; Liu, Jiling; Thornton, Michael A.

    2016-01-01

    This study examined at-risk boys' social self-efficacy and physical activity self-efficacy within Bandura's self-efficacy framework. A total of 97 boys, aged between 10 and 13 years, attending a summer sports camp completed questionnaires assessing their social self-efficacy, physical activity self- efficacy, prosocial behaviors, and effort.…

  10. EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1.

    Science.gov (United States)

    Lobo, Miguel J; Amaral, Margarida D; Zaccolo, Manuela; Farinha, Carlos M

    2016-07-01

    Cyclic AMP (cAMP) activates protein kinase A (PKA) but also the guanine nucleotide exchange factor 'exchange protein directly activated by cAMP' (EPAC1; also known as RAPGEF3). Although phosphorylation by PKA is known to regulate CFTR channel gating - the protein defective in cystic fibrosis - the contribution of EPAC1 to CFTR regulation remains largely undefined. Here, we demonstrate that in human airway epithelial cells, cAMP signaling through EPAC1 promotes CFTR stabilization at the plasma membrane by attenuating its endocytosis, independently of PKA activation. EPAC1 and CFTR colocalize and interact through protein adaptor NHERF1 (also known as SLC9A3R1). This interaction is promoted by EPAC1 activation, triggering its translocation to the plasma membrane and binding to NHERF1. Our findings identify a new CFTR-interacting protein and demonstrate that cAMP activates CFTR through two different but complementary pathways - the well-known PKA-dependent channel gating pathway and a new mechanism regulating endocytosis that involves EPAC1. The latter might constitute a novel therapeutic target for treatment of cystic fibrosis. PMID:27206858

  11. Human cellular differences in cAMP - CREB signaling correlate with light-dependent melatonin suppression and bipolar disorder

    NARCIS (Netherlands)

    Gaspar, Ludmila; van de Werken, Maan; Johansson, Anne-Sophie; Moriggi, Ermanno; Owe-Larsson, Bjorn; Kocks, Janwillem W. H.; Lundkvist, Gabriella B.; Gordijn, Marijke C. M.; Brown, Steven A.

    2014-01-01

    Various lines of evidence suggest a mechanistic role for altered cAMP-CREB (cAMP response element - binding protein) signaling in depressive and affective disorders. However, the establishment and validation of human inter-individual differences in this and other major signaling pathways has proven

  12. Documents sobre el monestir de Sant Pau del Camp, de Barcelona (segles XIII-XIV)

    OpenAIRE

    Mutgé Vives, Josefina

    1994-01-01

    Com que entre les moltes línies d'investigació cultivades pel Dr. Trenchs també hi figurava la història monàstica -només ens cal recordar que la seva tesi de llicenciatura, presentada en el llunya any de 1966, consistí en l'estudi de la Cartoixa de Scala Dei-, ens plau d'oferir-li aquí alguns documents inèdits sobre el monestir benedictí de Sant Pau del Camp, de Barcelona, procedents dels registres de cancelleria reial de l'Arxiu de la Corona d'Aragó, que constitueixen la primícia d'un futur ...

  13. Environmental Factors Affecting Mercury in Camp Far West Reservoir, California, 2001-03

    Science.gov (United States)

    Alpers, Charles N.; Stewart, A. Robin; Saiki, Michael K.; Marvin-DiPasquale, Mark C.; Topping, Brent R.; Rider, Kelly M.; Gallanthine, Steven K.; Kester, Cynthia A.; Rye, Robert O.; Antweiler, Ronald C.; De Wild, John F.

    2008-01-01

    This report documents water quality in Camp Far West Reservoir from October 2001 through August 2003. The reservoir, located at approximately 300 feet above sea level in the foothills of the northwestern Sierra Nevada, California, is a monomictic lake characterized by extreme drawdown in the late summer and fall. Thermal stratification in summer and fall is coupled with anoxic conditions in the hypolimnion. Water-quality sampling was done at approximately 3-month intervals on eight occasions at several stations in the reservoir, including a group of three stations along a flow path in the reservoir: an upstream station in the Bear River arm (principal tributary), a mid-reservoir station in the thalweg (prereservoir river channel), and a station in the deepest part of the reservoir, in the thalweg near Camp Far West Dam. Stations in other tributary arms of the reservoir included those in the Rock Creek arm of the reservoir, a relatively low-flow tributary, and the Dairy Farm arm, a small tributary that receives acidic, metal-rich drainage seasonally from the inactive Dairy Farm Mine, which produced copper, zinc, and gold from underground workings and a surface pit. Several water-quality constituents varied significantly by season at all sampling stations, including major cations and anions, total mercury (filtered and unfiltered samples), nitrogen (ammonia plus organic), and total phosphorus. A strong seasonal signal also was observed for the sulfurisotope composition of aqueous sulfate from filtered water. Although there were some spatial differences in water quality, the seasonal variations were more profound. Concentrations of total mercury (filtered and unfiltered water) were highest during fall and winter; these concentrations decreased at most stations during spring and summer. Anoxic conditions developed in deep parts of the reservoir during summer and fall in association with thermal stratification. The highest concentrations of methylmercury in unfiltered

  14. Electric Vehicle Preparedness: Task 1, Assessment of Fleet Inventory for Marine Corps Base Camp Lejeune

    Energy Technology Data Exchange (ETDEWEB)

    Schey, Stephen [Idaho National Lab. (INL), Idaho Falls, ID (United States); Francfort, Jim [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-01-01

    Several U.S. Department of Defense-based studies were conducted to identify potential U.S. Department of Defense transportation systems that are strong candidates for introduction or expansion of plug-in electric vehicles (PEVs). Task 1 included a survey of the inventory of non-tactical fleet vehicles at the Marine Corps Base Camp Lejeune (MCBCL) to characterize the fleet. This information and characterization will be used to select vehicles for monitoring that takes place during Task 2. This monitoring involves data logging of vehicle operation in order to identify the vehicle’s mission and travel requirements. Individual observations of these selected vehicles provide the basis for recommendations related to PEV adoption. It also identifies whether a battery electric vehicle or plug-in hybrid electric vehicle (collectively referred to as PEVs) can fulfill the mission requirements and provides observations related to placement of PEV charging infrastructure.

  15. Outbreak of leptospirosis during a scout camp in the Luxembourg Belgian province, Belgium, summer 2012.

    Science.gov (United States)

    Mori, M; VAN Esbroeck, M; Depoorter, S; Decaluwe, W; Vandecasteele, S J; Fretin, D; Reynders, M

    2015-06-01

    An outbreak of leptospirosis occurred in the South of Belgium, during August 2012, in teenagers who participated in two consecutive adventure scout camps near the Semois river. Among the symptomatic patient population (ten scouts), clinical manifestations included headache (70%), myalgia (50%), fever (50%), bilateral conjunctival injection (50%), general malaise (30%), vomiting (20%), anorexia (20%) and cough (20%). Some of the cases presented elevated blood creatinine (40%), or proteinuria (30%). Three patients were confirmed by serology and one by polymerase chain reaction. Potential risk factors included direct contact with a muskrat and indirect contact with potentially contaminated environments including the river water. Prospective environmental investigation carried out near the river banks 2 weeks after the outbreak identified Ondatra zibethicus (muskrat) as one Leptospira sp. reservoir. PMID:25311398

  16. Horizontalist Youth Camps and the Bolivarian Revolution: A Story of Blocked Diffusion

    Directory of Open Access Journals (Sweden)

    Lesley J. Wood

    2015-08-01

    Full Text Available Between 2001 and 2005, the Intercontinental Youth Camp at the World Social Forum in Porto Alegre, Brazil became associated with a decentralized, horizontalist form of organizing. When the polycentric forum took place in 2006, this horizontalist identity and strategy did not diffuse successfully to the new site in Caracas, Venezuela. This article argues that for diffusion to be successful, the local hosts must be able to deliberate on the locally new idea, see themselves as similar to the earlier users, and have the opportunity to adapt the tactic to the local context. Analysing interviews with participants, and activist writing, I argue that the relational context of Caracas, Venezuela, along with recent events in that city, made such processes impossible. In particular, the deliberation essential for diffusion was blocked by the centralization and polarization of the political field, the formalization of the potential adopters, and the temporal proximity of a similar event, the World Festival of Youth and Students.

  17. Neonatal intensive care in a Karen refugee camp: a 4 year descriptive study.

    Directory of Open Access Journals (Sweden)

    Claudia Turner

    Full Text Available BACKGROUND: A third of all deaths in children aged <5 years occur in the neonatal period. Neonatal intensive care is often considered too complex and expensive to be implemented in resource poor settings. Consequently the reductions that have been made in infant mortality in the poorest countries have not been made in the neonatal period. This manuscript describes the activities surrounding the introduction of special care baby unit (SCBU in a refugee setting and the resulting population impact. METHODS: A SCBU was developed in Maela refugee camp on the Thailand-Myanmar border. This unit comprised of a dedicated area, basic equipment, drugs and staff training. Training was built around neonatal guidelines, comprising six clinical steps: recognition, resuscitation, examination, supportive medical care, specialised medical care, and counselling of parents with sick newborns. RESULTS: From January 2008 until December 2011, 952 infants were admitted to SCBU. The main admission diagnoses were early onset neonatal sepsis, jaundice and prematurity. Early prematurity (<34 weeks carried the highest risk of mortality (OR 9.5, 95% CI 5.4-16.5, p<0.001. There was a significant decrease in mortality from 19.3% (2008 to 4.8% (2011 among the infants admitted for prematurity (p=0.03. The neonatal mortality in Maela camp as a whole declined by 51% from 21.8 to 10.7 deaths per 1000 live births over the corresponding period (p=0.04. Staff expressed more confidence in their ability to take care of neonates and there was a more positive attitude towards premature infants. CONCLUSION: Neonatal mortality can be reduced in a resource poor setting by introduction of a simple low cost unit specialising in care of sick neonates and run by local health workers following adequate training. Training in recognition and provision of simple interventions at a high standard can increase staff confidence and reduce fatalistic attitudes towards premature neonates.

  18. A program evaluation of Protovation Camp at an elementary school in North Carolina

    Science.gov (United States)

    Cavoly, Denise Y.

    The purpose of this program evaluation was to investigate the impact over time teachers' self-efficacies and the outcome expectancies of those who participated in an inquiry-based, hands-on, constructivist professional development program to learn science content. The hope was that after active participation in this inquiry-based professional development program that provides science inquiry experiences, the teachers, graduate students and elementary students would gain content knowledge, increase self-efficacies, and provide the outcome expectancies of the learning development program that provides science inquiry experiences. The mixed-methods approach used quantitative and qualitative data for campers, which consisted of pre-test and post-test scores on the Test of Science-Related Attitudes (TOSRA), the Draw-A-Scientist Test, Science Process Skills Inventory (SPSI) and content tests based on the camp activities. Additionally, TOSRA scores, Teacher Sense of Efficacy Scale (TSES), and Thinking about Science Survey (TSSI) results for the graduate students and elementary teachers were used along with qualitative data collected from plusdelta charts and interviews to determine the impact of participation in Protovation Camp on teachers and students. Results of the program evaluation indicated that when students were taught inquiry-based lessons that ignite wonder, both their attitudes toward science and their knowledge about science improved. An implication for teacher preparation programs was that practicing inquiry-based lessons on actual elementary students was an important component for teachers and graduate students as they prepare to positively impact student learning in their own classrooms. The findings of this study suggest that it is not just the length of the professional development program that is crucial, but the need for an implementation period while teachers work to transfer the learning to the classroom to their own students is critical to the

  19. Implementation of the Introductory Clinician Development Series: an optional boot camp for Emergency Medicine interns

    Directory of Open Access Journals (Sweden)

    Min AA

    2014-08-01

    Full Text Available Alice A Min,1 Lisa R Stoneking,1 Kristi H Grall,1 Karen Spear-Ellinwood2 1Department of Emergency Medicine, 2Office of Medical Student Education, University of Arizona, Tucson, AZ, USA Background: The transition from medical student to first-year intern can be challenging. The stress of increased responsibilities, the gap between performance expectations and varying levels of clinical skills, and the need to adapt to a new institutional space and culture can make this transition overwhelming. Orientation programs intend to help new residents prepare for their new training environment. Objective: To ease our interns' transition, we piloted a novel clinical primer course. We believe this course will provide an introduction to basic clinical knowledge and procedures, without affecting time allotted for mandatory orientation activities, and will help the interns feel better prepared for their clinical duties. Methods: First-year Emergency Medicine residents were invited to participate in this primer course, called the Introductory Clinician Development Series (or "intern boot camp", providing optional lecture and procedural skills instruction prior to their participation in the mandatory orientation curriculum and assumption of clinical responsibilities. Participating residents completed postcourse surveys asking for feedback on the experience. Results: Survey responses indicated that the intern boot camp helped first-year residents feel more prepared for their clinical shifts in the Emergency Department. Conclusion: An optional clinical introductory series can allow for maintenance of mandatory orientation activities and clinical shifts while easing the transition from medical student to clinician. Keywords: orientation, residency training, educational design

  20. Forskolin-free cAMP assay for Gi-coupled receptors.

    Science.gov (United States)

    Gilissen, Julie; Geubelle, Pierre; Dupuis, Nadine; Laschet, Céline; Pirotte, Bernard; Hanson, Julien

    2015-12-01

    G protein-coupled receptors (GPCRs) represent the most successful receptor family for treating human diseases. Many are poorly characterized with few ligands reported or remain completely orphans. Therefore, there is a growing need for screening-compatible and sensitive assays. Measurement of intracellular cyclic AMP (cAMP) levels is a validated strategy for measuring GPCRs activation. However, agonist ligands for Gi-coupled receptors are difficult to track because inducers such as forskolin (FSK) must be used and are sources of variations and errors. We developed a method based on the GloSensor system, a kinetic assay that consists in a luciferase fused with cAMP binding domain. As a proof of concept, we selected the succinate receptor 1 (SUCNR1 or GPR91) which could be an attractive drug target. It has never been validated as such because very few ligands have been described. Following analyses of SUCNR1 signaling pathways, we show that the GloSensor system allows real time, FSK-free detection of an agonist effect. This FSK-free agonist signal was confirmed on other Gi-coupled receptors such as CXCR4. In a test screening on SUCNR1, we compared the results obtained with a FSK vs FSK-free protocol and were able to identify agonists with both methods but with fewer false positives when measuring the basal levels. In this report, we validate a cAMP-inducer free method for the detection of Gi-coupled receptors agonists compatible with high-throughput screening. This method will facilitate the study and screening of Gi-coupled receptors for active ligands. PMID:26386312

  1. Implementation Approach for Electric Vehicles at Marine Corps Base Camp Lejeune. Task 4

    Energy Technology Data Exchange (ETDEWEB)

    Schey, Stephen [Idaho National Lab. (INL), Idaho Falls, ID (United States); Francfort, Jim [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-11-01

    Battelle Energy Alliance, LLC, managing and operating contractor for the U.S. Department of Energy’s Idaho National Laboratory, is the lead laboratory for U.S. Department of Energy Advanced Vehicle Testing. Battelle Energy Alliance, LLC contracted with Intertek Testing Services, North America (Intertek) to conduct several U.S. Department of Defense base studies to identify potential U.S. Department of Defense transportation systems that are strong candidates for introduction or expansion of plug-in electric vehicles (PEVs). This study is focused on the Marine Corps Base Camp Lejeune (MCBCL) located in North Carolina. Task 1 consisted of a survey of the non-tactical fleet of vehicles at MCBCL to begin the review of vehicle mission assignments and types of vehicles in service. In Task 2, daily operational characteristics of vehicles were identified to select vehicles for further monitoring and attachment of data loggers. Task 3 recorded vehicle movements in order to characterize the vehicles’ missions. The results of the data analysis and observations were provided. Individual observations of the selected vehicles provided the basis for recommendations related to PEV adoption, i.e., whether a battery electric vehicle (BEV) or plug-in hybrid electric vehicle (PHEV) (collectively PEVs) can fulfill the mission requirements. It also provided the basis for recommendations related to placement of PEV charging infrastructure. This report focuses on an implementation plan for the near-term adoption of PEVs into the MCBCL fleet. Intertek acknowledges the support of Idaho National Laboratory, Marine Corps headquarters, and Marine Corps Base Camp Lejeune fleet management and personnel for participation in this study. Intertek is pleased to provide this report and is encouraged by enthusiasm and support from MCBCL personnel.

  2. Involvement of cAMP and protein kinase A in conidial differentiation by Erysiphe graminis f. sp. hordei.

    Science.gov (United States)

    Hall, A A; Bindslev, L; Rouster, J; Rasmussen, S W; Oliver, R P; Gurr, S J

    1999-11-01

    Erysiphe graminis f. sp. hordei, the causal agent of barley powdery mildew, is an obligate biotroph. On arrival on the host, a primary germ tube (PGT) emerges from the conidium. An appressorial germ tube (AGT) then appears, forms an appressorium, and effects host penetration. Such developmental precision may be due to multiple, plant-derived signals and to endogenous tactile and chemical signals. The transduction mechanism remains obscure. The isolation of an expressed sequence tag (EST) homologue of the catalytic subunit of cyclic AMP (cAMP)-dependent protein kinase A (PKA) enabled the corresponding gene to be characterized and the transcript to be identified in conidia and in PGT and AGT stage spores. cAMP-dependent PKA activity was detected in ungerminated conidia. These data suggest that PKA and cAMP are involved in conidial development. To substantiate this we exploited the responses of developing conidia to various surfaces, including exposure to the host leaf (fully inductive to AGT formation), cellulose membrane (semi-inductive), and glass (non-inductive). Assessment of fungal development, following application of exogenous cAMP or cAMP analogues, revealed that, at different concentrations and on different surfaces, cAMP either promoted or inhibited conidial differentiation. Various PKA inhibitors were tested for their effect on PKA activity and conidial development. A negative correlation was established between PKA inhibition in vitro and fungal development in vivo. Taken collectively, these data suggest that PKA and cAMP play a role in conidial differentiation in this obligate, plant-pathogenic fungus. PMID:10550894

  3. Modulatory effects of cAMP and PKC activation on gap junctional intercellular communication among thymic epithelial cells

    Directory of Open Access Journals (Sweden)

    Neves-dos-Santos Sandra

    2010-01-01

    Full Text Available Abstract Background We investigated the effects of the signaling molecules, cyclic AMP (cAMP and protein-kinase C (PKC, on gap junctional intercellular communication (GJIC between thymic epithelial cells (TEC. Results Treatment with 8-Br-cAMP, a cAMP analog; or forskolin, which stimulates cAMP production, resulted in an increase in dye transfer between adjacent TEC, inducing a three-fold enhancement in the mean fluorescence of coupled cells, ascertained by flow cytometry after calcein transfer. These treatments also increased Cx43 mRNA expression, and stimulated Cx43 protein accumulation in regions of intercellular contacts. VIP, adenosine, and epinephrine which may also signal through cyclic nucleotides were tested. The first two molecules did not mimic the effects of 8-Br-cAMP, however epinephrine was able to increase GJIC suggesting that this molecule functions as an endogenous inter-TEC GJIC modulators. Stimulation of PKC by phorbol-myristate-acetate inhibited inter-TEC GJIC. Importantly, both the enhancing and the decreasing effects, respectively induced by cAMP and PKC, were observed in both mouse and human TEC preparations. Lastly, experiments using mouse thymocyte/TEC heterocellular co-cultures suggested that the presence of thymocytes does not affect the degree of inter-TEC GJIC. Conclusions Overall, our data indicate that cAMP and PKC intracellular pathways are involved in the homeostatic control of the gap junction-mediated communication in the thymic epithelium, exerting respectively a positive and negative role upon cell coupling. This control is phylogenetically conserved in the thymus, since it was seen in both mouse and human TEC preparations. Lastly, our work provides new clues for a better understanding of how the thymic epithelial network can work as a physiological syncytium.

  4. β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D.

    Directory of Open Access Journals (Sweden)

    Thomas Trian

    Full Text Available BACKGROUND AND OBJECTIVE: Asthma is associated with airway narrowing in response to bronchoconstricting stimuli and increased airway smooth muscle (ASM mass. In addition, some studies have suggested impaired β-agonist induced ASM relaxation in asthmatics, but the mechanism is not known. OBJECTIVE: To characterize the potential defect in β-agonist induced cAMP in ASM derived from asthmatic in comparison to non-asthmatic subjects and to investigate its mechanism. METHODS: We examined β(2-adrenergic (β(2AR receptor expression and basal β-agonist and forskolin (direct activator of adenylyl cyclase stimulated cAMP production in asthmatic cultured ASM (n = 15 and non-asthmatic ASM (n = 22. Based on these results, PDE activity, PDE4D expression and cell proliferation were determined. RESULTS: In the presence of IBMX, a pan PDE inhibitor, asthmatic ASM had ∼50% lower cAMP production in response to isoproterenol, albuterol, formoterol, and forskolin compared to non-asthmatic ASM. However when PDE4 was specifically inhibited, cAMP production by the agonists and forskolin was normalized in asthmatic ASM. We then measured the amount and activity of PDE4, and found ∼2-fold greater expression and activity in asthmatic ASM compared to non-asthmatic ASM. Furthermore, inhibition of PDE4 reduced asthmatic ASM proliferation but not that of non-asthmatic ASM. CONCLUSION: Decreased β-agonist induced cAMP in ASM from asthmatics results from enhanced degradation due to increased PDE4D expression. Clinical manifestations of this dysregulation would be suboptimal β-agonist-mediated bronchodilation and possibly reduced control over increasing ASM mass. These phenotypes appear to be "hard-wired" into ASM from asthmatics, as they do not require an inflammatory environment in culture to be observed.

  5. Les limites extérieures du camp de réfugiés palestiniens d'Al Buss à Tyr (Liban)

    OpenAIRE

    Doraï, Kamel

    2000-01-01

    Dans les camps du sud Liban, ici Al-Buss à l'entrée nord de la ville de Tyr, la limite entre le camp et la ville est beaucoup plus marquée. Pour contrôler les entrées et sorties du camp, les rues ont été barrées par les autorités libanaises, ne laissant aux voitures qu'une seule entrée et deux sorties contrôlées par l'armée libanaise.

  6. "Ya no estás más a mi lado, corazón" : estética Camp en América Latina

    OpenAIRE

    Hueso Fibla, Silvia

    2012-01-01

    Esta tesis doctoral consta de tres capítulos cuyo recorrido pretende ilustrar que la puerta de entrada a la Estética Camp pasa por una mirada diferente sobre los productos culturales de masas y que su puerta de salida en América Latina atraviesa la Estética Neobarroca; por tanto, el Camp resulta tanto física como conceptualmente central en el trabajo. Se inserta el análisis de tres novelas y una obra teatral para mostrar cuáles son los mecanismos que el Camp adopta en América Latina: Tengo mi...

  7. Effect of electroacupuncture for different duration of time on the contents of cAMP in the central nervous system of rats

    International Nuclear Information System (INIS)

    Objective: To explore the relationship between acupuncture analgesia and the change of contents of cAMP of the rat brain. Methods: The contents of cAMP of brain after electroacupuncture (EA) for 15, 30 or 45 minutes were measured by radioimmunoassay (RIA). Results: The contents of cAMP in whole brain after EA for 15 and 30 minutes and that in diencephalon for 30 minutes were lowered remarkably (P < 0.05) while the threshold of pain elevated. Conclusion: The results show that the optimal duration for acupuncture analgesia may be 30 minutes

  8. A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis

    OpenAIRE

    Ding, Bo; Abe, Jun-ichi; Wei, Heng; Xu, Haodong; Che, Wenyi; Aizawa, Toru; Liu, Weimin; Molina, Carlos A.; Sadoshima, Junichi; Blaxall, Burns C.; Berk, Bradford C.; Yan, Chen

    2005-01-01

    cAMP plays crucial roles in cardiac remodeling and the progression of heart failure. Recently, we found that expression of cAMP hydrolyzing phosphodiesterase 3A (PDE3A) was significantly reduced in human failing hearts, accompanied by up-regulation of inducible cAMP early repressor (ICER) expression. Angiotensin II (Ang II) and the β-adrenergic receptor agonist isoproterenol (ISO) also induced persistent PDE3A down-regulation and concomitant ICER up-regulation in vitro, which is important in ...

  9. Training and deployment of lay refugee/internally displaced persons to provide basic health services in camps: a systematic review

    Directory of Open Access Journals (Sweden)

    John E. Ehiri

    2014-10-01

    Full Text Available Background: Training of lay refugees/internally displaced persons (IDPs and deploying them to provide basic health services to other women, children, and families in camps is perceived to be associated with public health benefits. However, there is limited evidence to support this hypothesis. Objectives: To assess the effects of interventions to train and deploy lay refugees and/or IDPs for the provision of basic health service to other women, children, and families in camps. Methods: PubMed, Science and Social Science Citation Indices, PsycINFO, EMBASE, POPLINE, CINAHL, and reference lists of relevant articles were searched (from inception to June 30, 2014 with the aim of identifying studies that reported the effects of interventions that trained and deployed lay refugees and/or IDPs for the provision of basic health service to other women, children, and families in camps. Two investigators independently reviewed all titles and abstracts to identify potentially relevant articles. Discrepancies were resolved by repeated review, discussion, and consensus. Study quality assessment was undertaken using standard protocols. Results: Ten studies (five cross-sectional, four pre-post, and one post-test only conducted in Africa (Guinea and Tanzania, Central America (Belize, and Asia (Myanmar were included. The studies demonstrated some positive impact on population health associated with training and deployment of trained lay refugees/IDPs as health workers in camps. Reported effects included increased service coverage, increased knowledge about disease symptoms and prevention, increased adoption of improved treatment seeking and protective behaviors, increased uptake of services, and improved access to reproductive health information. One study, which assessed the effect of peer refugee health education on sexual and reproductive health, did not demonstrate a marked reduction in unintended pregnancies among refugee/IDP women. Conclusion: Although

  10. Incidence and risk factors for Malaria, pneumonia and diarrhea in children under 5 in UNHCR refugee camps: A retrospective study

    Directory of Open Access Journals (Sweden)

    Hershey Christine L

    2011-10-01

    Full Text Available Abstract Background United Nations High Commissioner for Refugees (UNHCR refugee camps are located predominantly in rural areas of Africa and Asia in protracted or post-emergency contexts. Recognizing the importance of malaria, pneumonia and diarrheal diseases as major causes of child morbidity and mortality in refugee camps, we analyzed data from the UNHCR Health Information System (HIS to estimate incidence and risk factors for these diseases in refugee children younger than five years of age. Methods Data from 90 UNHCR camps in 16 countries, including morbidity, mortality, health services and refugee health status, were obtained from the UNHCR HIS for the period January 2006 to February 2010. Monthly camp-level data were aggregated to yearly estimates for analysis and stratified by location in Africa (including Yemen or Asia. Poisson regression models with random effects were constructed to identify factors associated with malaria, pneumonia and diarrheal diseases. Spatial patterns in the incidence of malaria, pneumonia and diarrheal diseases were mapped to identify regional heterogeneities. Results Malaria and pneumonia were the two most common causes of mortality, with confirmed malaria and pneumonia each accounting for 20% of child deaths. Suspected and confirmed malaria accounted for 23% of child morbidity and pneumonia accounted for 17% of child morbidity. Diarrheal diseases were the cause of 7% of deaths and 10% of morbidity in children under five. Mean under-five incidence rates across all refugee camps by region were: malaria [Africa 84.7 cases/1000 U5 population/month (95% CI 67.5-102.0, Asia 2.2/1000/month (95% CI 1.4-3.0]; pneumonia [Africa 59.2/1000/month (95% CI 49.8-68.7, Asia 254.5/1000/month (95% CI 207.1-301.8]; and diarrheal disease [Africa 35.5/1000/month (95% CI 28.7-42.4, Asia 69.2/1000/month (95% CI 61.0-77.5]. Measles was infrequent and accounted for a small proportion of child morbidity (503 cases, Conclusions As in

  11. The Greek military camp in the ten thousand´s army

    Directory of Open Access Journals (Sweden)

    Alvárez Rico, Mauricio G.

    2002-12-01

    Full Text Available The first and main conclusion of this study of the Xenophon´s works is that the Greek military camp should be the subject of research and should get more than ten pages at most in any handbook on Greek warfare. Once the castramental vocabulary problem is resolved, and we know the exact difference on meaning between words like τὸ στρατόπεδον, τὰ ὄπλα or σκηνὲω, it will be possible to attempt an approximation to Greek castramental theory of the 4th century as it would have been described in lost contemporary works, such as the one by Aeneas Tacticus. The Greek military camp seems to have had a high level of professional organisation, with a regular plan and internal structure, a very sophisticated watch guard system and a routine that shows the generals concern for the order and discipline of their troops. Inside the camp it was the συσκηνὶα (the group of soldiers who shared the same tent the basic logistical (and also probably, tactical unit in the Greek armies on campaign.

    La conclusión principal de este estudio de las obras de Jenofonte es que el campamento militar griego puede y debe ser investigado, pudiéndosele dedicar más de las diez páginas que como mucho se le han venido otorgando en los manuales de historia militar de la Grecia clásica. Una vez solventado el problema del vocabulario, y conociendo la diferencia exacta de significado entre términos como τὸ στρατόπεδον, τὰ ὄπλα o σκηνὲω hemos podido aproximarnos a la teoría castramental griega del s. IV tal y como pudo aparecer en obras hoy perdidas como la de Eneas Táctico. La castramentación griega parece haber alcanzado un alto grado de profesionalidad, con campamentos que mostraban un plano y una estructura interna regular, con un sofisticado sistema de guardias, y un horario que demuestra la preocupación de los generales por el mantenimiento del orden y la disciplina entre la tropa. Dentro del

  12. A novel proxy links CAMP volcanism with end-Triassic mass extinction and early Jurassic evolution

    Science.gov (United States)

    Ruhl, M.; Bjerrum, C. J.; Frei, R.

    2011-12-01

    Global mass extinction events are marked by a major loss of terrestrial and marine biodiversity and the global collapse of ecosystems during times of extensive volcanic activity and the emplacement of large igneous provinces (LIPs). Large-scale greenhouse gas release, initiated by volcanism, had a profound impact on global geochemical cycles (e.g. initiating strong perturbations in δ13C records). Hence, these events may be regarded as natural deep-time analogues for studying mechanistic feedbacks between rapid and large/scale greenhouse gas emissions, environmental change and biotic crises. Such studies require high resolution stratigraphic correlation between volcanic activity, disruption of global geochemical cycles and biotic crises, which at present is poorly constrained. Here we present a novel proxy that records explosive continental volcanic activity in distant marine shale sediments. The proxy builds on the relative abundance of the trace elements Lu, Hf, Y and Nb (monitored as the (Lu/ Hf)/(Y/ Nb)-ratio). We test the method on a marine sedimentary record comprising Central Atlantic Magmatic Province (CAMP) volcanism and the associated end-Triassic global mass extinction, at ~201.38 Ma. We show that the onset of sharp well-defined peaks in the (Lu/ Hf)/(Y/ Nb)-ratio coincides with the end-Triassic biotic crisis. Subsequent subordinate peaks closely correspond to periods of early Jurassic biotic radiation and evolution. Large-scale volcanic activity therefore not only initiated the end-Triassic mass extinction, it possibly also actively punctuated and regulated the pace of early Jurassic evolution. Further, the proxy also records the timing of Siberian Traps volcanism relative to the end-Permian mass extinction, the largest extinction in Earth's history. Hence, this proxy for the first time allows causality studies between increased volcanic activity, disruption of global geochemical cycles and global biodiversity loss, in unprecedented stratigraphic

  13. Fish fauna of the Camp dels Ninots locality (Pliocene; Caldes de Malavella, province of Girona, Spain) - first results with notes on palaeoecology and taphonomy

    Czech Academy of Sciences Publication Activity Database

    Přikryl, Tomáš; Gómez de Soler, B.; Oms, O.; Roubach, S.; Blain, H-A.; Agustí, J.

    2016-01-01

    Roč. 28, č. 3 (2016), s. 347-357. ISSN 0891-2963 Institutional support: RVO:67985831 Keywords : Camp dels Ninots * Cyprinidae * maar lake * NE Spain * Pliocene * Teleostei Subject RIV: DB - Geology ; Mineralogy

  14. Audubon National Wildlife Refuge, Lake Nettie National Wildlife Refuge, Camp Lake Easement Refuge, Wintering River Easement Refuge, Cottonwood Lake Easement Refuge, Sheyenne Lake Easement Refuge : Narrative report : 1969

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Audubon National Wildlife Refuge including Lake Nettie National Wildlife Refuge, Camp Lake Easement Refuge, Cottonwood Lake...

  15. Poor housing quality increases risk of rodent infestation and Lassa fever in refugee camps of Sierra Leone.

    Science.gov (United States)

    Bonner, Phillip Cullison; Schmidt, Wolf-Peter; Belmain, Steven R; Oshin, Babafemi; Baglole, Debbie; Borchert, Matthias

    2007-07-01

    Lassa fever, a viral hemorrhagic fever endemic in parts of West Africa, is a severe febrile illness transmitted to humans by the rodent Mastomys natalensis. To determine risk of Lassa fever in households in Sierra Leonean refugee camps, we analyzed the spatial relationships between households with a Lassa case and focal locations of potential rodent habitats. Quality and hygiene factors of households were assessed to determine possible risk factors for household rodent infestation and occurrence of Lassa fever. The odds to have a rat burrow were higher in case houses than in control houses (OR 24, 95% CI 6.0-93). Case houses scored significantly worse in the quality of housing and external hygiene. These findings suggest that risk of Lassa fever in refugee camps depends on individual housing quality and the hygiene of the immediate surrounding environment. PMID:17620650

  16. TEWS'98. Final report [5th annual International Science Camp: The Earth We Share 1998, Golden, CO

    Energy Technology Data Exchange (ETDEWEB)

    Mae C. Jemison

    1999-04-06

    The fifth annual International Science Camp The Earth We Share 1998 (TEWS'98) was held at the Colorado School of Mines located in Goldez Colorado. TEWS98 was a four week residential program which focused on providing a meaningful science education experience while developing critical thinking skills. Thirty three students, three teachers, four college interns and the camp administrator lived and worked together while developing solutions to several worldwide problems. These problems are called the Discovery Topics and they are: (1) design the worlds perfect house; (2) how many people can the world hold; and (3) predict the hot stocks for the year 2030. The participants, both students and staff came from different countries all over the world The following countries were represented: The United Kingdom, Sierra Leone (West Africa), Ireland, USA Nigeria, West Indies and Barbados.

  17. An outbreak of hepatitis A virus among children in a flood rescue camp: A post-disaster catastrophe

    Directory of Open Access Journals (Sweden)

    S Pal

    2016-01-01

    Full Text Available We report an outbreak of acute viral hepatitis among children in a flood rescue camp at Rudraprayag district of Uttarakhand State, India. In May 2013, there was a disastrous natural calamity, The Himalayan Tsunami in Himalayan and Sub-Himalayan region of Uttarakhand. More than 5700 people were feared dead, and thousands were sheltered in different rescue camps. A linkage was hypothesised between the infected individuals and the common water sources feared of being contaminated faecally. Aetiological agent of the present outbreak was HAV that is emerging in an outbreak form in India, emphasizing a definite need for formulating mandatory vaccination and proper control strategies. The report exemplifies the basic problems encountered after a natural calamity.

  18. An outbreak of hepatitis A virus among children in a flood rescue camp: A post-disaster catastrophe.

    Science.gov (United States)

    Pal, S; Juyal, D; Sharma, M; Kotian, S; Negi, V; Sharma, N

    2016-01-01

    We report an outbreak of acute viral hepatitis among children in a flood rescue camp at Rudraprayag district of Uttarakhand State, India. In May 2013, there was a disastrous natural calamity, The Himalayan Tsunami in Himalayan and Sub-Himalayan region of Uttarakhand. More than 5700 people were feared dead, and thousands were sheltered in different rescue camps. A linkage was hypothesised between the infected individuals and the common water sources feared of being contaminated faecally. Aetiological agent of the present outbreak was HAV that is emerging in an outbreak form in India, emphasizing a definite need for formulating mandatory vaccination and proper control strategies. The report exemplifies the basic problems encountered after a natural calamity. PMID:27080781

  19. Reciprocal bystander effect between α-irradiated macrophage and hepatocyte is mediated by cAMP through a membrane signaling pathway

    Energy Technology Data Exchange (ETDEWEB)

    He, Mingyuan [Institute of Radiation Medicine, Fudan University, No. 2094 Xie-Tu Road, Shanghai 200032 (China); Department of Radiation Oncology, China–Japan Union Hospital of Jilin University, Changchun 130033 (China); Dong, Chen; Xie, Yuexia; Li, Jitao; Yuan, Dexiao; Bai, Yang [Institute of Radiation Medicine, Fudan University, No. 2094 Xie-Tu Road, Shanghai 200032 (China); Shao, Chunlin, E-mail: clshao@shmu.edu.cn [Institute of Radiation Medicine, Fudan University, No. 2094 Xie-Tu Road, Shanghai 200032 (China)

    2014-05-15

    Highlights: • α-Irradiation induced reciprocal effects between macrophage and hepatocyte cells. • cAMP played a protective role in regulating the reverse bystander effect. • cAMP communication contributed to the reciprocal effects via membrane signaling. • p53 was required for cAMP-regulated bystander effect in the recipient cells. - Abstract: Irradiated cells can induce biological effects on vicinal non-irradiated bystander cells, meanwhile the bystander cells may rescue the irradiated cells through a feedback signal stress. To elucidate the nature of this reciprocal effect, we examined the interaction between α-irradiated human macrophage cells U937 and its bystander HL-7702 hepatocyte cells using a cell co-culture system. Results showed that after 6 h of cell co-culture, mitochondria depolarization corresponding to apoptosis was significantly induced in the HL-7702 cells, but the formation of micronuclei in the irradiated U937 cells was markedly decreased compared to that without cell co-culture treatment. This reciprocal effect was not observed when the cell membrane signaling pathway was blocked by filipin that inhibited cAMP transmission from bystander cells to irradiated cells. After treatment of cells with exogenous cAMP, forskolin (an activator of cAMP) or KH-7 (an inhibitor of cAMP), respectively, it was confirmed that cAMP communication from bystander cells to targeted cells could mitigate radiation damage in U739 cells, and this cAMP insufficiency in the bystander cells contributed to the enhancement of bystander apoptosis. Moreover, the bystander apoptosis in HL-7702 cells was aggravated by cAMP inhibition but it could not be evoked when p53 of HL-7702 cells was knocked down no matter of forskolin and KH-7 treatment. In conclusion, this study disclosed that cAMP could be released from bystander HL-7702 cells and compensated to α-irradiated U937 cells through a membrane signaling pathway and this cAMP communication played a profound role in

  20. Effect of a wildlife conservation camp experience in China on student knowledge of animals, care, propensity for environmental stewardship, and compassionate behavior toward animals

    Science.gov (United States)

    Bexell, Sarah M.

    The goal of conservation education is positive behavior change toward animals and the environment. This study was conducted to determine whether participation in a wildlife conservation education camp was effective in positively changing 8-12 year old students': (a) knowledge of animals, (b) care about animals, (c) propensity for environmental and wildlife stewardship, and (d) compassionate behavior toward animals. During the summer of 2005, 2 five-day camps were conducted at 2 zoological institutions in Chengdu, China. The camp curriculum was influenced by theory and research on the following: conservation psychology, social learning theory, empathy and moral development theory, socio-biological theory, constructivist theory, and conservation science. Camp activities were sensitive to Chinese culture and included Chinese conservation issues. Activities were designed to help children form bonds with animals and care enough about them to positively change their behavior toward animals and the environment. This mixed methods study triangulated quantitative and qualitative data from six sources to answer the following: (1) Did camp increase student knowledge of animals? (2) Did camp increase student caring about animals? (3) Did camp increase student propensity for environmental and wildlife stewardship? (4) Did camp affect student compassionate behavior toward animals? A conservation stewards survey revealed significant increases on pre-post, self-report of knowledge, care, and propensity. Pre-post, rubric-scored responses to human-animal interaction vignettes indicated a significant increase in knowledge, and stable scores on care and propensity. Qualitative data from student journals, vignettes, and end-of-camp questionnaires demonstrated knowledge, caring, and propensity, and revealed the emergent theme empathy. To address question 4, instructors tallied campers' behavior toward animals using a student behavior ethogram. Occurrence of positive behaviors was

  1. Reciprocal bystander effect between α-irradiated macrophage and hepatocyte is mediated by cAMP through a membrane signaling pathway

    International Nuclear Information System (INIS)

    Highlights: • α-Irradiation induced reciprocal effects between macrophage and hepatocyte cells. • cAMP played a protective role in regulating the reverse bystander effect. • cAMP communication contributed to the reciprocal effects via membrane signaling. • p53 was required for cAMP-regulated bystander effect in the recipient cells. - Abstract: Irradiated cells can induce biological effects on vicinal non-irradiated bystander cells, meanwhile the bystander cells may rescue the irradiated cells through a feedback signal stress. To elucidate the nature of this reciprocal effect, we examined the interaction between α-irradiated human macrophage cells U937 and its bystander HL-7702 hepatocyte cells using a cell co-culture system. Results showed that after 6 h of cell co-culture, mitochondria depolarization corresponding to apoptosis was significantly induced in the HL-7702 cells, but the formation of micronuclei in the irradiated U937 cells was markedly decreased compared to that without cell co-culture treatment. This reciprocal effect was not observed when the cell membrane signaling pathway was blocked by filipin that inhibited cAMP transmission from bystander cells to irradiated cells. After treatment of cells with exogenous cAMP, forskolin (an activator of cAMP) or KH-7 (an inhibitor of cAMP), respectively, it was confirmed that cAMP communication from bystander cells to targeted cells could mitigate radiation damage in U739 cells, and this cAMP insufficiency in the bystander cells contributed to the enhancement of bystander apoptosis. Moreover, the bystander apoptosis in HL-7702 cells was aggravated by cAMP inhibition but it could not be evoked when p53 of HL-7702 cells was knocked down no matter of forskolin and KH-7 treatment. In conclusion, this study disclosed that cAMP could be released from bystander HL-7702 cells and compensated to α-irradiated U937 cells through a membrane signaling pathway and this cAMP communication played a profound role in

  2. Contributo di dati di gravità nella valutazione del vulcanismo CAMP in Africa Nord-Occidentale

    OpenAIRE

    Fabbri, Julius

    2015-01-01

    La domanda alla base di questa ricerca è stata se il metodo della gravimetria satellitare possa essere utilizzato per seguire le unità geologiche anche in luoghi difficilmente accessibili. L’obiettivo di questa ricerca è di verificare se le missioni satellitari di nuova generazione permettano di identificare la più grande delle province ignee della Terra (Bertrand et al., 2013), nota come CAMP (Central Atlantic Magmatic Province) in Africa nord-occidentale. Oltre alle motivazioni scientifiche...

  3. Pediatric Cardiology Boot Camp: Description and Evaluation of a Novel Intensive Training Program for Pediatric Cardiology Trainees.

    Science.gov (United States)

    Ceresnak, Scott R; Axelrod, David M; Motonaga, Kara S; Johnson, Emily R; Krawczeski, Catherine D

    2016-06-01

    The transition from residency to subspecialty fellowship in a procedurally driven field such as pediatric cardiology is challenging for trainees. We describe and assess the educational value of a pediatric cardiology "boot camp" educational tool designed to help prepare trainees for cardiology fellowship. A two-day intensive training program was provided for pediatric cardiology fellows in July 2015 at a large fellowship training program. Hands-on experiences and simulations were provided in: anatomy, auscultation, echocardiography, catheterization, cardiovascular intensive care (CVICU), electrophysiology (EP), heart failure, and cardiac surgery. Knowledge-based exams as well as surveys were completed by each participant pre-training and post-training. Pre- and post-exam results were compared via paired t tests, and survey results were compared via Wilcoxon rank sum. A total of eight participants were included. After boot camp, there was a significant improvement between pre- and post-exam scores (PRE 54 ± 9 % vs. POST 85 ± 8 %; p ≤ 0.001). On pre-training survey, the most common concerns about starting fellowship included: CVICU emergencies, technical aspects of the catheterization/EP labs, using temporary and permanent pacemakers/implantable cardiac defibrillators (ICDs), and ECG interpretation. Comparing pre- and post-surveys, there was a statistically significant improvement in the participants comfort level in 33 of 36 (92 %) areas of assessment. All participants (8/8, 100 %) strongly agreed that the boot camp was a valuable learning experience and helped to alleviate anxieties about the start of fellowship. A pediatric cardiology boot camp experience at the start of cardiology fellowship can provide a strong foundation and serve as an educational springboard for pediatric cardiology fellows. PMID:26961569

  4. Level of development of the physical components of social activity schoolchildren 10-11 years children summer camp

    OpenAIRE

    Chovgan R.Ya.; Ivanishyn I.M.; Prezliata A.V.

    2014-01-01

    Purpose: to determine the level of physical health of schoolchildren. Material : the study involved 146 children aged 10-11 years. Results : the questions of children's health issues such: the state of development of physical qualities, cardiovascular and respiratory systems, the ratio of children to their own health, interest in physical education means in terms of the Camp. The characteristic of the state of physical health and adaptive capacity of the organism respondents. Found that 50.7 ...

  5. Management of Emergency Peace Education Programmes for Boko Haram Internally Displaced Persons in Yola Refugee Camp of Adamawa State Nigeria

    OpenAIRE

    Kabiru Mohammed Badau; Olowoselu Abdulrasheed

    2015-01-01

    Education is a fundamental right of children even under emergency situations. The purpose of this study was to asses, access resources, curriculum activities, coordination of capacity building in managing emergency peace education programmes for Boko Haram internally displaced persons in Yola Refugee Camp of Adamawa State. Data was collected using teachers assessment of emergency peace Education for Internally Displaced Persons questionnaire (TAEPEIDPQ) consisting of twenty (20) items. The fi...

  6. Physiological and Molecular Effects of the Cyclic Nucleotides cAMP and cGMP on Arabidopsis thaliana

    KAUST Repository

    Herrera, Natalia M.

    2012-12-01

    The cyclic nucleotide monophosphates (CNs), cAMP and cGMP, are second messengers that participate in the regulation of development, metabolism and adaptive responses. In plants, CNs are associated with the control of pathogen responses, pollen tube orientation, abiotic stress response, membrane transport regulation, stomatal movement and light perception. In this study, we hypothesize that cAMP and cGMP promote changes in the transcription level of genes related to photosynthesis, high light and membrane transport in Arabidopsis thaliana leaves and, that these changes at the molecular level can have functional biological consequences. For this reason we tested if CNs modulate the photosynthetic rate, responses to high light and root ion transport. Real time quantitative PCR was used to assess transcription levels of selected genes and infrared gas analyzers coupled to fluorescence sensors were used to measure the photosynthetic parameters. We present evidence that both cAMP and cGMP modulate foliar mRNA levels early after stimulation. The two CNs trigger different responses indicating that the signals have specificity. A comparison of proteomic and transcriptional changes suggest that both transcriptional and post-transcriptional mechanisms are modulated by CNs. cGMP up-regulates the mRNA levels of components of the photosynthesis and carbon metabolism. However, neither cAMP nor cGMP trigger differences in the rate of carbon assimilation, maximum efficiency of the photosystem II (PSII), or PSII operating efficiency. It was also demonstrated that CN regulate the expression of its own targets, the cyclic nucleotide gated channels - CNGC. Further studies are needed to identify the components of the signaling transduction pathway that mediate cellular changes and their respective regulatory and/or signaling roles.

  7. Prevalence of Malaria and Treatment Seeking Behaviours among Pregnant Women in Postconflict Internally Displaced Persons' Camps in Gulu District

    OpenAIRE

    Obol James Henry; Kitara David Lagoro; Christopher Garimoi Orach

    2012-01-01

    Background. Malaria is a serious health problem that contributes greatly to morbidity and mortality in Uganda. It mainly affects pregnant women and children under 5 years of age. Malaria accounts for 9–14% of inpatient deaths in public and private not-for-profit health facilities in Uganda. Methods. A cross-sectional study using quantitative data collection technique was carried out in Gulu district IDP camps. Proportion to size cluster sampling method was used to determine the numbers of pre...

  8. Effects of Exergame Play on EF in Children and Adolescents at a Summer Camp for Low Income Youth

    OpenAIRE

    2014-01-01

    Past research has suggested exergame play improves adolescents’ executive function (EF) skills. EF change in 70 African American and Hispanic/Latino 10- to 16-year-olds participating in an inner-city summer camp was assessed following five 30-minute exergame play sessions. Children’s EF scores improved from pre- to posttest, and factors related to this change were examined. The number of exergame sessions the participants attended predicted posttest scores. In addition, level of achievement d...

  9. A silver lining in strife torn camps of Bodoland, Assam: a case study intersecting gender, disaster, and mental health

    OpenAIRE

    Budhiswatya Shankar Das; Arif Ali

    2016-01-01

    A case of a 40-year-old, Muslim woman, educated up to class IV, homemaker by profession, hailing from a lower socioeconomic background of Chirang district of Assam was referred to medical camp, with symptoms of reduced interest in daily activities, increased tension, fearfulness, with decreased amount of sleep and appetite. Psychiatric social work assessment showed that she had a frictional and conflicting relationship with her husband. Due to which her quality of life was compromised. On fur...

  10. Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics.

    Science.gov (United States)

    Golkowski, Martin; Shimizu-Albergine, Masami; Suh, Hyong Won; Beavo, Joseph A; Ong, Shao-En

    2016-07-01

    Many cellular processes are modulated by cyclic AMP and nucleotide phosphodiesterases (PDEs) regulate this second messenger by catalyzing its breakdown. The major unique function of testicular Leydig cells is to produce testosterone in response to luteinizing hormone (LH). Treatment of Leydig cells with PDE inhibitors increases cAMP levels and the activity of its downstream effector, cAMP-dependent protein kinase (PKA), leading to a series of kinase-dependent signaling and transcription events that ultimately increase testosterone release. We have recently shown that PDE4B and PDE4C as well as PDE8A and PDE8B are expressed in rodent Leydig cells and that combined inhibition of PDE4 and PDE8 leads to dramatically increased steroid biosynthesis. Here we investigated the effect of PDE4 and PDE8 inhibition on the molecular mechanisms of cAMP actions in a mouse MA10 Leydig cell line model with SILAC mass spectrometry-based phosphoproteomics. We treated MA10 cells either with PDE4 family specific inhibitor (Rolipram) and PDE8 family specific inhibitor (PF-04957325) alone or in combination and quantified the resulting phosphorylation changes at five different time points between 0 and 180min. We identified 28,336 phosphosites from 4837 proteins and observed significant regulation of 749 sites in response to PDE4 and PDE8 inhibitor treatment. Of these, 132 phosphosites were consensus PKA sites. Our data strongly suggest that PDE4 and PDE8 inhibitors synergistically regulate phosphorylation of proteins required for many different cellular processes, including cell cycle progression, lipid and glucose metabolism, transcription, endocytosis and vesicle transport. Our data suggests that cAMP, PDE4 and PDE8 coordinate steroidogenesis by acting on not one rate-limiting step but rather multiple pathways. Moreover, the pools of cAMP controlled by these PDEs also coordinate many other metabolic processes that may be regulated to assure timely and sufficient testosterone secretion

  11. Over the Borders. Building and launching the Virtual Campus SW-VirCamp. An external evaluation report.

    OpenAIRE

    Lahti Edmark, Helene

    2010-01-01

    The Social Work Virtual Campus (SW-VirCamp) is an Internet based international pedagogical pilot project aiming at 1) developing a virtual campus for social work education; 2) developing a new e-learning module in Community Work and Community Development; 3) arranging a pilot course in the mentioned subjects. The project is financed by the EU Comission within the Lifelong learning ERASMUS program. The report is an external evaluation of the project primarily based on interviews with parti...

  12. Harboring illnesses: On the association between disease and living conditions in a Palestinian refugee camp in Lebanon

    OpenAIRE

    Habib, Rima R.; BASMA, SHIRAZ H.; Yeretzian, Joumana S.

    2006-01-01

    This research examined the association between the domestic built environment in a Palestinian refugee camp in Beirut, Lebanon, and the presence of illness among household members. Data on the domestic built environment, socio-demographics and health were collected in 860 households. The association between the presence of illness among household members and three environmental indices, namely infrastructure and services, housing conditions, and crowding was evaluated. These indices were base...

  13. Nutritional Characterization and Phenolic Profiling of Moringa oleifera Leaves Grown in Chad, Sahrawi Refugee Camps, and Haiti

    OpenAIRE

    Alessandro Leone; Giovanni Fiorillo; Franca Criscuoli; Stefano Ravasenghi; Laura Santagostini; Gelsomina Fico; Angela Spadafranca; Alberto Battezzati; Alberto Schiraldi; Federica Pozzi; Sara di Lello; Sandro Filippini; Simona Bertoli

    2015-01-01

    Moringa oleifera is a plant that grows in tropical and subtropical areas of the world. Its leaves are rich of nutrients and bioactive compounds. However, several differences are reported in the literature. In this article we performed a nutritional characterization and a phenolic profiling of M. oleifera leaves grown in Chad, Sahrawi refugee camps, and Haiti. In addition, we investigated the presence of salicylic and ferulic acids, two phenolic acids with pharmacological activity, whose prese...

  14. Characterization of the Vegetation and Soil of the Forest Communities at Camp Brookside in Summers County, West Virginia

    OpenAIRE

    Mitchem, David O.

    2004-01-01

    Camp Brookside, a seasonal island, is located on the floodplain of the New River in Summers County, West Virginia. This island hosts several rare plant species and a rare plant community known as a riverside flat rock plant community (FRPC). The FRPC is characterized by flat resistant sandstone shelves above water that are generally associated with rapids. Flooding has historically maintained the FRPC by scouring any soil off of the bedrock and leaving sand deposits in cracks or depressions. ...

  15. Micronutrient status in lactating mothers before and after introduction of fortified flour: cross-sectional surveys in Maela refugee camp

    OpenAIRE

    Stuetz, Wolfgang; Carrara, Verena Ilona; McGready, Rose; Lee, Sue Jean; Erhardt, Juergen Georg; Breuer, Joern; Biesalski, Hans Konrad; Nosten, François Henry

    2011-01-01

    Background Deficiency of micronutrients is common in refugee populations. Objectives Identify deficiencies and whether provided supplements and wheat flour fortified with 10 micronutrients impacts upon status among breast-feeding women from Maela refugee camp. Methods Two sequential cross-sectional studies were conducted in different groups of lactating mothers at 12 weeks postpartum. The first survey was before and the second 4–5 months after micronutrient fortified flour (MFF) had been prov...

  16. Basis of the International Research Project of the Roman Military Camps in the Barbarian Territory to the North of Carnuntum

    Czech Academy of Sciences Publication Activity Database

    Groh, S.; Komoróczy, Balázs; Vlach, Marek; Sedlmayer, H.

    2015-01-01

    Roč. 42, č. 1 (2015), s. 749-754. ISSN 0323-9535. [International Congress of Roman Frontier Studies /22./. Ruse, 06.09.2012-11.09.2012] Grant ostatní: Rada Programu interní podpory projektů mezinárodní spolupráce AV ČR(CZ) M300011201 Institutional support: RVO:68081758 Keywords : Roman temporary camps * Middle Danube region * Marcomannic wars * field methodology * environmental analyses Subject RIV: AC - Archeology, Anthropology, Ethnology

  17. How do radical climate movements negotiate their environmental and their social agendas? A study of debates within the Camp for Climate Action (UK)

    OpenAIRE

    Schlembach, Raphael

    2011-01-01

    This is a case study of the Camp for Climate Action, which has held several high-profile protest events in the UK since its inception in 2006. It analyses the Camp as a contested space where different emphases on environmental and social priorities have to be negotiated by its activists. The article considers areas of contestation where concerns over climate change meet questions of social justice. These are structured around tangible issues of campaigning, such as opposition to new coal-fire...

  18. Transiently Increasing cAMP Levels Selectively in Hippocampal Excitatory Neurons during Sleep Deprivation Prevents Memory Deficits Caused by Sleep Loss

    OpenAIRE

    Havekes, Robbert; Bruinenberg, Vibeke M.; Tudor, Jennifer C; Ferri, Sarah L.; Baumann, Arnd; Meerlo, Peter; Abel, Ted

    2014-01-01

    The hippocampus is particularly sensitive to sleep loss. Although previous work has indicated that sleep deprivation impairs hippocampal cAMP signaling, it remains to be determined whether the cognitive deficits associated with sleep deprivation are caused by attenuated cAMP signaling in the hippocampus. Further, it is unclear which cell types are responsible for the memory impairments associated with sleep deprivation. Transgenic approaches lack the spatial resolution to manipulate specific ...

  19. Mechanism of the down-regulation of cAMP receptor protein by glucose in Escherichia coli: role of autoregulation of the crp gene.

    OpenAIRE

    ISHIZUKA, H; Hanamura, A; Inada, T; Aiba, H.

    1994-01-01

    Glucose causes catabolite repression by lowering the intracellular levels of both cAMP and cAMP receptor protein (CRP) in Escherichia coli. The molecular mechanism underlying the down-regulation of CRP by glucose has been investigated. We show that glucose lowers the level of crp mRNA without affecting its stability. Replacement of the crp promoter with the bla promoter almost completely abolishes the glucose-mediated regulation of crp expression. Only a slight reduction in the crp expression...

  20. The nutrition and health profile of the Turkish female national weightlifting team who attended to pre-camp of Beijing Olympics- Pilot study

    OpenAIRE

    Ozdemir, Gunay; Ersoy, Gülgün

    2010-01-01

    In this study, National Turkish weightlifter female team who joined preparation camp before 2008 Beijing Olympiads nutrition habits, food intake, using of nutritional ergogenic aids, anthropometric measures and biochemical findings have been evaluated. Nine athletes who have been taken the camp participated to this study. The information were collected about their anthropometric (height, body weight, waist-hip circumference, waist / height ratio, body fat values) and biochemical measures, nut...