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Sample records for californium 256

  1. Californium Electrodepositions at Oak Ridge National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Boll, Rose Ann [ORNL

    2015-01-01

    Electrodepositions of californium isotopes were successfully performed at Oak Ridge National Laboratory (ORNL) during the past year involving two different types of deposition solutions, ammonium acetate (NH4C2H3O2) and isobutanol ((CH3)2CHCH2OH). A californium product that was decay enriched in 251Cf was recovered for use in super-heavy element (SHE) research. This neutron-rich isotope, 251Cf, provides target material for SHE research for the potential discovery of heavier isotopes of Z=118. The californium material was recovered from aged 252Cf neutron sources in storage at ORNL. These sources have decayed for over 30 years, thus providing material with a very high 251Cf-to-252Cf ratio. After the source capsules were opened, the californium was purified and then electrodeposited using the isobutanol method onto thin titanium foils for use in an accelerator at the Joint Institute for Nuclear Research in Dubna, Russia. Another deposition method, ammonium acetate, was used to produce a deposition containing 1.7 0.1 Ci of 252Cf onto a stainless steel substrate. This was the largest single electrodeposition of 252Cf ever prepared. The 252Cf material was initially purified using traditional ion exchange media, such as AG50-AHIB and AG50-HCl, and further purified using a TEVA-NH4SCN system to remove any lanthanides, resulting in the recovery of 3.6 0.1 mg of purified 252Cf. The ammonium acetate deposition was run with a current of 1.0 amp, resulting in a 91.5% deposition yield. Purification and handling of the highly radioactive californium material created additional challenges in the production of these sources.

  2. Historical Review of Californium-252 Discovery and Development

    Science.gov (United States)

    Stoddard, D. H.

    1985-01-01

    This paper discusses the discovery and history of californium 252. This isotope may be synthesized by irradiating plutonium 239, plutonium 242, americium 243, or curium 244 with neutrons in a nuclear reactor. Various experiments and inventions involving Cf conducted at the Savannah River Plant are discussed. The evolution of radiotherapy using californium 252 is reviewed. (PLG)

  3. Production, Distribution, and Applications of Californium-252 Neutron Sources

    Energy Technology Data Exchange (ETDEWEB)

    Balo, P.A.; Knauer, J.B.; Martin, R.C.

    1999-10-03

    The radioisotope {sup 252}Cf is routinely encapsulated into compact, portable, intense neutron sources with a 2.6-year half-life. A source the size of a person's little finger can emit up to 10{sup 11} neutrons/s. Californium-252 is used commercially as a reliable, cost-effective neutron source for prompt gamma neutron activation analysis (PGNAA) of coal, cement, and minerals, as well as for detection and identification of explosives, laud mines, and unexploded military ordnance. Other uses are neutron radiography, nuclear waste assays, reactor start-up sources, calibration standards, and cancer therapy. The inherent safety of source encapsulations is demonstrated by 30 years of experience and by U.S. Bureau of Mines tests of source survivability during explosions. The production and distribution center for the U. S Department of Energy (DOE) Californium Program is the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory (ORNL). DOE sells The radioisotope {sup 252}Cf is routinely encapsulated into compact, portable, intense neutron sources with a 2.6- year half-life. A source the size of a person's little finger can emit up to 10 neutrons/s. Californium-252 is used commercially as a reliable, cost-effective neutron source for prompt gamma neutron activation analysis (PGNAA) of coal, cement, and minerals, as well as for detection and identification of explosives, laud mines, and unexploded military ordnance. Other uses are neutron radiography, nuclear waste assays, reactor start-up sources, calibration standards, and cancer therapy. The inherent safety of source encapsulations is demonstrated by 30 years of experience and by U.S. Bureau of Mines tests of source survivability during explosions. The production and distribution center for the U. S Department of Energy (DOE) Californium Program is the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory(ORNL). DOE sells {sup 252}Cf to commercial

  4. Teratogenic effect of Californium-252 irradiation in rats

    Energy Technology Data Exchange (ETDEWEB)

    Satow, Yukio; Lee, Juing-Yi; Hori, Hiroshi; Okuda, Hiroe; Tsuchimoto, Shigeo; Sawada, Shozo; Yokoro, Kenjiro (Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology)

    1989-06-01

    The teratogenicity of Californium-252 (Cf-252) irradiation which generates approximately 70% 2.3 MeV fast neutron and 30% gamma rays was evaluated. A single whole body exposure of Cf-252 at various doses was given to pregnant rats on day 8 or 9 of pregnancy, followed by microscopic autopsy of the fetuses at the terminal stage of pregnancy to search for external and internal malformations. For comparison, pregnant rats were irradiated with various doses of Cobalt-60 (Co-60) standard gamma rays at the same dose rate (1 rad/min.). The doses were 20-120 rad of Cf-252 and 80-220 rad of Co-60. Using frequency of radiation induced malformations observed on day 8 of pregnancy as an index, relative biological effectiveness (RBE) of 2.3-2.7 was obtained from the straight line obtained by modifying by the least squares method the frequency curves of malformed fetuses in total implants and in surviving fetuses. The types of malformations induced by Cf-252 and Co-60 irradiation were alike. Using fetal LD/sub 50/ as an index, 2.4 was obtained as RBE when irradiated on day 8 of pregnancy and 3.1 as that when irradiated on day 9. The results showed that Cf-252 had stronger a teratogenic effect than Co-60 gamma rays. (author).

  5. 30 CFR 256.49 - Lease form.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Lease form. 256.49 Section 256.49 Mineral... IN THE OUTER CONTINENTAL SHELF Issuance of Leases § 256.49 Lease form. Oil and gas leases and leases for sulphur shall be issued on forms approved by the Director. Other mineral leases shall be issued...

  6. 24 CFR 983.256 - Lease.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Lease. 983.256 Section 983.256... VOUCHER (PBV) PROGRAM Occupancy § 983.256 Lease. (a) Tenant's legal capacity. The tenant must have legal capacity to enter a lease under state and local law. “Legal capacity” means that the tenant is bound by...

  7. 30 CFR 256.37 - Lease term.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Lease term. 256.37 Section 256.37 Mineral... IN THE OUTER CONTINENTAL SHELF Issuance of Leases § 256.37 Lease term. (a)(1) All oil and gas leases... unusually deep water or other unusually adverse conditions. (2) If your oil and gas lease is in water...

  8. 15 CFR 256.1 - Introduction.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Introduction. 256.1 Section 256.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF... PROGRAM § 256.1 Introduction. This part states policies and procedures concerning the Research...

  9. Imaging by photon counting with 256 x 256 pixel matrix

    CERN Document Server

    Tlustos, Lukas; Heijne, Erik H M; Llopart-Cudie, Xavier

    2004-01-01

    Using 0.25 mum standard CMOS we have developed 2-D semiconductor matrix detectors with sophisticated functionality integrated inside each pixel of a hybrid sensor module. One of these sensor modules is a matrix of 256 multiplied by 256 square 55mum pixels intended for X- ray imaging. This device is called 'Medipix2' and features a fast amplifier and two-level discrimination for signals between 1000 and 100000 equivalent electrons, with overall signal noise similar to 150 e- rms. Signal polarity and comparator thresholds are programmable. A maximum count rate of nearly 1 MHz per pixel can be achieved, which corresponds to an average flux of 3 multiplied by 10exp10 photons per cm2. The selected signals can be accumulated in each pixel in a 13- bit register. The serial readout takes 5-10 ms. A parallel readout of similar to 300 mus could also be used. Housekeeping functions such as local dark current compensation, test pulse generation, silencing of noisy pixels and threshold tuning in each pixel contribute to t...

  10. Imaging by photon counting with 256x256 pixel matrix

    Science.gov (United States)

    Tlustos, Lukas; Campbell, Michael; Heijne, Erik H. M.; Llopart, Xavier

    2004-09-01

    Using 0.25µm standard CMOS we have developed 2-D semiconductor matrix detectors with sophisticated functionality integrated inside each pixel of a hybrid sensor module. One of these sensor modules is a matrix of 256x256 square 55µm pixels intended for X-ray imaging. This device is called 'Medipix2' and features a fast amplifier and two-level discrimination for signals between 1000 and 100000 equivalent electrons, with overall signal noise ~150 e- rms. Signal polarity and comparator thresholds are programmable. A maximum count rate of nearly 1 MHz per pixel can be achieved, which corresponds to an average flux of 3x10exp10 photons per cm2. The selected signals can be accumulated in each pixel in a 13-bit register. The serial readout takes 5-10 ms. A parallel readout of ~300 µs could also be used. Housekeeping functions such as local dark current compensation, test pulse generation, silencing of noisy pixels and threshold tuning in each pixel contribute to the homogeneous response over a large sensor area. The sensor material can be adapted to the energy of the X-rays. Best results have been obtained with high-resistivity silicon detectors, but also CdTe and GaAs detectors have been used. The lowest detectable X-ray energy was about 4 keV. Background measurements have been made, as well as measurements of the uniformity of imaging by photon counting. Very low photon count rates are feasible and noise-free at room temperature. The readout matrix can be used also with visible photons if an energy or charge intensifier structure is interposed such as a gaseous amplification layer or a microchannel plate or acceleration field in vacuum.

  11. Apparatus for the measurement of total body nitrogen using prompt neutron activation analysis with californium-252.

    Science.gov (United States)

    Mackie, A; Hannan, W J; Smith, M A; Tothill, P

    1988-01-01

    Details of clinical apparatus designed for the measurement of total body nitrogen (as an indicator of body protein), suitable for the critically ill, intensive-care patient are presented. Californium-252 radio-isotopic neutron sources are used, enabling a nitrogen measurement by prompt neutron activation analysis to be made in 40 min with a precision of +/- 3.2% for a whole body dose equivalent of 0.145 mSv. The advantages of Californium-252 over alternative neutron sources are discussed. A comparison between two irradiation/detection geometries is made, leading to an explanation of the geometry adopted for the apparatus. The choice of construction and shielding materials to reduce the count rate at the detectors and consequently to reduce the pile-up contribution to the nitrogen background is discussed. Salient features of the gamma ray spectroscopy system to reduce spectral distortion from pulse pile-up are presented.

  12. Improved security analysis of Fugue-256

    DEFF Research Database (Denmark)

    Gauravaram, Praveen; Bagheri, Nasour; Knudsen, Lars Ramkilde;

    2011-01-01

    in the G transform. Next we improve the designers’ meet-in-the-middle preimage attack on Fugue-256 from 2480 time and memory to 2416. Next we study the security of Fugue-256 against free-start distinguishers and free-start collisions. In this direction, we use an improved variant of the differential...

  13. Improved security analysis of Fugue-256 (poster)

    DEFF Research Database (Denmark)

    Gauravaram, Praveen; Knudsen, Lars Ramkilde; Bagheri, Nasoor;

    2011-01-01

    We present some improved analytical results as part of the ongoing work on the analysis of Fugue-256 hash function, a second round candidate in the NIST's SHA3 competition. First we improve Aumasson and Phans' integral distinguisher on the 5.5 rounds of the final transformation of Fugue-256 to 16...

  14. 17 CFR 256.301 - Organization.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Organization. 256.301 Section... COMPANY ACT OF 1935 Service Company Property Accounts § 256.301 Organization. This account shall include... incident to organizing a corporation or other form of organization and putting it into readiness to...

  15. 17 CFR 256.232 - Accounts payable.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Accounts payable. 256.232... SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 7. Current and Accrued Liabilities § 256.232 Accounts payable. This account...

  16. 40 CFR 25.6 - Public meetings.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Public meetings. 25.6 Section 25.6... meetings. Public meetings are any assemblies or gathering, (such as conferences, informational sessions... to attend. Public meetings are less formal than public hearings. They do not require...

  17. Dicty_cDB: SLC256 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLC256 (Link to dictyBase) - G01081 DDB0191143 Contig-U11921-1 SLC...256P (Link to Original site) SLC256F 738 SLC256Z 555 SLC256P 1293 - - Show SLC256 Library SL (Link to library) Clone ID SLC...Contig-U11921-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SL/SLC2-C/SLC...256Q.Seq.d/ Representative seq. ID SLC256P (Link to Original site) Representative DNA sequence >SLC256 (SLC256Q) /CSM/SL/SLC...2-C/SLC256Q.Seq.d/ AAAAAAAAAAATGATTTATAATCAAGCTTTAATTGAAATTACAAAACAAGGTGCGGTGGC TGTAGAA

  18. Spontaneous Partitioning of Californium from Curium: Curious Cases from the Crystallization of Curium Coordination Complexes

    Energy Technology Data Exchange (ETDEWEB)

    Cary, Samantha K.; Silver, Mark A.; Liu, Guokui; Wang, Jamie C.; Bogart, Justin A.; Stritzinger, Jared T.; Arico, Alexandra A.; Hanson, Kenneth; Schelter, Eric J.; Albrecht-Schmitt, Thomas E.

    2015-12-07

    The reaction of 248CmCl3 with excess 2,6-pyridinedicarboxylic acid (DPA) under mild solvothermal conditions results in crystallization of the tris-chelate complex Cm(HDPA)3·H2O. Approximately half of the curium remains in solution at the end of this process, and evaporation of the mother liquor results in crystallization of the bis-chelate complex [Cm(HDPA)- (H2DPA)(H2O)2Cl]Cl·2H2O. 248Cm is the daughter of the α decay of 252Cf and is extracted in high purity from this parent. However, trace amounts of 249,250,251Cf are still present in all samples of 248Cm. During the crystallization of Cm(HDPA)3·H2O and [Cm(HDPA)(H2DPA)(H2O)2Cl]Cl·2H2O, californium(III) spontaneously separates itself from the curium complexes and is found doped within crystals of DPA in the form of Cf(HDPA)3. These results add to the growing body of evidence that the chemistry of californium is fundamentally different from that of earlier actinides.

  19. Dicty_cDB: VHI256 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VH (Link to library) VHI256 (Link to dictyBase) - - - Contig-U15499-1 VHI256P (Link to Original site) VHI...256F 519 VHI256Z 499 VHI256P 998 - - Show VHI256 Library VH (Link to library) Clone ID VHI... URL http://dictycdb.biol.tsukuba.ac.jp/CSM/VH/VHI2-C/VHI256Q.Seq.d/ Representative seq. ID VHI...256P (Link to Original site) Representative DNA sequence >VHI256 (VHI256Q) /CSM/VH/VHI2-C/VHI2...ficant alignments: (bits) Value VSB592 (VSB592Q) /CSM/VS/VSB5-D/VSB592Q.Seq.d/ 948 0.0 VHI264 (VHI264Q) /CSM/VH/VHI2-C/VHI

  20. Dicty_cDB: VSI256 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 256F (Link to Original site) VSI256F 546 - - - - - - Show VSI256 Library VS (Link to library) Clone ID VSI...Representative seq. ID VSI256F (Link to Original site) Representative DNA sequence >VSI256 (VSI256Q) /CSM/VS/VSI2-C/VSI...-cDNA Score E Sequences producing significant alignments: (bits) Value VSI256 (VSI256Q) /CSM/VS/VSI2-C/VSI25...VS (Link to library) VSI256 (Link to dictyBase) - G21492 DDB0204751 Contig-U06933-1 VSI...256 (Link to dictyBase) Atlas ID - NBRP ID G21492 dictyBase ID DDB0204751 Link to Contig Contig-U06933-1 Original si

  1. 49 CFR 256.11 - Applications.

    Science.gov (United States)

    2010-10-01

    ... discussion of each organization's role; (4) A preliminary statement of work, and a detailed estimate of all... TRANSPORTATION FINANCIAL ASSISTANCE FOR RAILROAD PASSENGER TERMINALS Regulations Governing Applications for and Disbursement of Financial Assistance § 256.11 Applications. (a) Incorporation by reference in application...

  2. Cache Timing Analysis of HC-256

    DEFF Research Database (Denmark)

    Zenner, Erik

    2008-01-01

    In this paper, we describe an abstract model of cache timing attacks that can be used for designing ciphers. We then analyse HC-256 under this model, demonstrating a cache timing attack under certain strong assumptions. From the observations made in our analysis, we derive a number of design prin...

  3. A Cache Timing Analysis of HC-256

    DEFF Research Database (Denmark)

    Zenner, Erik

    2009-01-01

    In this paper, we describe a cache-timing attack against the stream cipher HC-256, which is the strong version of eStream winner HC-128. The attack is based on an abstract model of cache timing attacks that can also be used for designing stream ciphers. From the observations made in our analysis,...

  4. 17 CFR 256.123 - Investment in associate companies.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Investment in associate companies. 256.123 Section 256.123 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... UTILITY HOLDING COMPANY ACT OF 1935 2. Investments § 256.123 Investment in associate companies....

  5. 30 CFR 256.8 - Leasing maps and diagrams.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Leasing maps and diagrams. 256.8 Section 256.8 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF SULPHUR OR..., General § 256.8 Leasing maps and diagrams. (a) Any area of the OCS which has been appropriately platted...

  6. 42 CFR 403.256 - Loss ratio supporting data.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Loss ratio supporting data. 403.256 Section 403.256... Ratio Provisions § 403.256 Loss ratio supporting data. (a) For purposes of requesting CMS certification under § 403.232, the insuring organization must submit the following loss ratio data to CMS for...

  7. 32 CFR 256.7 - Accident potential zone guidelines.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Accident potential zone guidelines. 256.7 Section 256.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS AIR INSTALLATIONS COMPATIBLE USE ZONES § 256.7 Accident potential zone...

  8. 40 CFR 256.25 - Recommendation for inactive facilities.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommendation for inactive facilities. 256.25 Section 256.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... Disposal Programs § 256.25 Recommendation for inactive facilities. Inactive facilities that continue...

  9. 24 CFR 3282.256 - Distributor or dealer complaint handling.

    Science.gov (United States)

    2010-04-01

    ... handling. 3282.256 Section 3282.256 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT MANUFACTURED HOME PROCEDURAL AND ENFORCEMENT REGULATIONS Dealer and Distributor Responsibilities § 3282.256 Distributor or dealer complaint handling. (a) When a distributor...

  10. 42 CFR 84.256 - Quality control requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Quality control requirements. 84.256 Section 84.256... § 84.256 Quality control requirements. (a) In addition to the construction and performance requirements specified in §§ 84.251, 84.252, 84.253, 84.254, and 84.255, the quality control requirements in...

  11. Clinical Report on Californium-252 Neutron Intraluminal Brachytherapy Combined with External Irradiation for Cervical Carcinoma Treatment

    Institute of Scientific and Technical Information of China (English)

    Huanyu Zhao; Keming Wang; Jian Sun; Xin Geng; Weiming Zhang

    2006-01-01

    OBJECTIVE To observe the curative effects and complications of californium-252 (252Cf) neutron intraluminal brachytherapy (IBT) combined with external irradiation (El) for treatment of cervical carcinoma.METHODS From December 2000 to December 2004, 128 cases of cervical carcinoma staged into ⅡA~ⅢB according to the International Federation of Gynecology and Obstetrics (FIGO) standards were treated with 252Cf neutron IBT using 8~10 Gy per fraction, once a week. The total dose at reference A point was 36~40 Gy in 4~5 fractions. From the second day after 252Cf neutron IBT treatment, the whole pelvic cavity was treated with 60Co γ-ray El, applying 2 Gy per fraction, 4 times per week. After 20~25 Gy of El, the center of the whole pelvic field was blocked with 4 cm of lead in width. The total dose of El was 45~50 Gy.RESULTS The short-term therapeutic effects were CR 95.3% and PR 4.7%. The 3 and 5-year local control rates were 93.5% and 87.9%. The overall 3-year survival rate was 87.5% and for Stages Ⅱ and Ⅲ , 90.9%and 81.5% respectively; the overall 5-year survival rate was 70% and for Stages Ⅱ and Ⅲ, 76.2% and 61% respectively. The rate of radiation complications was 4.7% for radiation cystitis, 7.8% for radiation proctitis, 6.3%for vagina contracture and adhesion and 5.5% for protracted radiation proctitis.CONCLUSION An combination of 252Cf neutron IBT with El for treatment of cervical carcinoma can be well-tolerated by cervical carcinoma patients. The rate of local tumor control is high and radiation complications are few.

  12. Application of TSH bioindicator for studying the biological efficiency of neutrons from californium-252 source

    Energy Technology Data Exchange (ETDEWEB)

    Cebulska-Wasilewska, A.; Rekas, K. [Institute of Nuclear Physics, Cracow (Poland); Kim, J.K. [Korea Atomic Energy Research Inst., Taejon (Korea, Republic of)

    1997-12-31

    The effectiveness of neutrons from a Californium-252 source in the induction of various abnormalities in the Tradescantia clone 4430 stamen hair cells (TSH-assay) was studied. The special attention was paid to check whether any enhancement in effects caused by process of boron neutron capture is visible in the cells enriched with boron ions. Two chemicals (borax and BSH) were applied to introduce boron-10 ions into cells. Inflorescence, normal or pretreated with chemicals containing boron, were irradiated in the air with neutrons from a Cf-252 source at KAERI, Taejon, Korea. To estimate the relative biological effectiveness (RBE) in the induction of gene mutations of the neutron beam under the study, Tradescantia inflorescences, without any chemical pretreatment, were irradiated with various doses of X-rays. The ranges of radiation doses used were 0-0.1 Gy in neutrons and 0-0.5 Gy in X-rays. After the time needed to complete the postirradiation repair Tradescantia cuttings were transferred to Cracow, where screening of gene and lethal; mutations, cell cycle alterations in somatic cells have been done, and dose response relationships were figured. The maximal RBE values were estimated in the range of 4.6-6.8. Alterations of RBE value were observed; from 6.8 to 7.8 in the case of plants pretreated with 240 ppm of B-10 from borax, and 4.6 to 6.1 in the case of 400 ppm of B-10 from BSH. Results showed a slight, although statistically insignificant increase in biological efficacy of radiation from the Cf-252 source in samples pretreated with boron containing chemicals. (author)

  13. 50 CFR 216.256 - Applications for Letters of Authorization.

    Science.gov (United States)

    2010-10-01

    ... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND... in the Gulf of Mexico § 216.256 Applications for Letters of Authorization. To incidentally...

  14. Study of the shielding for spontaneous fission sources of Californium-252; Estudio de blindaje para fuentes de fision espontanea de Californio-252

    Energy Technology Data Exchange (ETDEWEB)

    Davila R, I

    1991-06-15

    A shielding study is made to attenuate, until maximum permissible levels, the neutrons radiation and photons emitted by spontaneous fission coming from a source of Californium-252. The compound package by a database (Library DLC-23) and the ANISNW code is used, in it version for personal computer. (Author)

  15. 17 CFR 256.411.5 - Investment tax credit.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Investment tax credit. 256.411... HOLDING COMPANY ACT OF 1935 Income and Expense Accounts § 256.411.5 Investment tax credit. (a) This account shall be debited with the amounts of investment tax credits related to service company...

  16. 30 CFR 256.56 - Lease-specific abandonment accounts.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Lease-specific abandonment accounts. 256.56... OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Bonding § 256.56 Lease-specific abandonment accounts. (a) The Regional Director may authorize you to establish a lease-specific abandonment account...

  17. 17 CFR 256.01-11 - Methods of allocation.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Methods of allocation. 256.01... HOLDING COMPANY ACT OF 1935 General Instructions § 256.01-11 Methods of allocation. Indirect costs and... applicable and currently effective methods of allocation filed with the Commission. Both direct and...

  18. 17 CFR 256.923 - Outside services employed.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Outside services employed. 256.923 Section 256.923 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED... 930.1, General advertising expenses. Separate subaccounts shall be provided for auditing,...

  19. 17 CFR 256.211 - Miscellaneous paid-in capital.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Miscellaneous paid-in capital. 256.211 Section 256.211 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... capital. This account shall include the balance of all other credits for paid-in capital which are...

  20. 17 CFR 256.201 - Common stock issued.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Common stock issued. 256.201... COMPANY ACT OF 1935 Liabilities and Other Credit Accounts § 256.201 Common stock issued. This account shall include the par or stated value of all common capital stock issued and outstanding....

  1. 27 CFR 24.256 - Bottle aging wine.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Bottle aging wine. 24.256 Section 24.256 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... not have labels affixed until the wine is removed for consumption or sale. However, the bins,...

  2. 17 CFR 256.101 - Service company property.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Service company property. 256...) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 Balance Sheet Accounts: Assets and Other Debit Accounts § 256.101...

  3. 25 CFR 256.24 - Will I need flood insurance?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Will I need flood insurance? 256.24 Section 256.24... Will I need flood insurance? You will need flood insurance if your dwelling is located in an area identified as having special flood hazards under the Flood Disaster Protection Act of 1973 (Pub. L....

  4. 40 CFR 421.256 - Pretreatment standards for new sources.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for new sources. 421.256 Section 421.256 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY Primary Precious Metals...

  5. An SEU resistant 256K SOI SRAM

    Science.gov (United States)

    Hite, L. R.; Lu, H.; Houston, T. W.; Hurta, D. S.; Bailey, W. E.

    1992-12-01

    A novel SEU (single event upset) resistant SRAM (static random access memory) cell has been implemented in a 256K SOI (silicon on insulator) SRAM that has attractive performance characteristics over the military temperature range of -55 to +125 C. These include worst-case access time of 40 ns with an active power of only 150 mW at 25 MHz, and a worst-case minimum WRITE pulse width of 20 ns. Measured SEU performance gives an Adams 10 percent worst-case error rate of 3.4 x 10 exp -11 errors/bit-day using the CRUP code with a conservative first-upset LET threshold. Modeling does show that higher bipolar gain than that measured on a sample from the SRAM lot would produce a lower error rate. Measurements show the worst-case supply voltage for SEU to be 5.5 V. Analysis has shown this to be primarily caused by the drain voltage dependence of the beta of the SOI parasitic bipolar transistor. Based on this, SEU experiments with SOI devices should include measurements as a function of supply voltage, rather than the traditional 4.5 V, to determine the worst-case condition.

  6. 76 FR 11433 - Federal Transition To Secure Hash Algorithm (SHA)-256

    Science.gov (United States)

    2011-03-02

    ... Hash Algorithm (SHA)-256 AGENCY: Department of Defense (DoD), General Services Administration (GSA... agencies about ways for the acquisition community to transition to Secure Hash Algorithm SHA-256. SHA-256... Hash Algorithm SHA-256'' in all correspondence related to this public meeting. FOR FURTHER...

  7. Long-term effects of an intracavitary treatment with californium-252 on normal tissue. [Swine, /sup 226/Ra

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, M.F.; Beamer, J.L.; Mahony, T.D.; Cross, F.T.; Lund, J.E.; Endres, G.W.R.

    1976-01-01

    About one hundred fifty swine were exposed to either radium-226 or californium-252 sources in the uterine cervix to determine an RBE for both acute and long-term effects. That value for early changes in the tissues at risk in the treatment of cervical cancer was between 6.2 and 6.8. The incidence of complications increased with time after exposure, especially among animals treated with /sup 252/Cf. Analysis of rectal injury showed that ulceration occurred frequently within a year postexposure at doses between 1600 and 2400 rad calculated at 2 cm lateral to the source midline. Fat necrosis and smooth muscle atrophy, resulting in a local rectal stricture, were delayed changes observed in some animals. The lower ureter was the site for a greater frequency of complications than the GI tract. Ureteral stricture often occurred at doses of 1200 rad from /sup 252/Cf and 7000 rad from /sup 226/Ra. Observation of delayed effects in the uterine-cervix in animals held up to 4 years postexposure indicate that the RBE for /sup 252/Cf may be increased to a value as high as 18, while repair may have even decreased it to about 5.6 in the rectum. Fifty swine are still being observed for long-term effects after doses above 800 rad from /sup 252/Cf and 5000 rad from /sup 226/Ra.

  8. Development of electron beam ion source charge breeder for rare isotopes at Californium Rare Isotope Breeder Upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Kondrashev, S.; Dickerson, C.; Levand, A.; Ostroumov, P. N.; Pardo, R. C.; Savard, G.; Vondrasek, R. [Physics Division, Argonne National Laboratory, Argonne, Illinois 60439 (United States); Alessi, J.; Beebe, E.; Pikin, A. [Collider-Accelerator Department, Brookhaven National Laboratory, Upton, New York 11973 (United States); Kuznetsov, G. I.; Batazova, M. A. [Budker Institute of Nuclear Physics, Novosibirsk 630090 (Russian Federation)

    2012-02-15

    Recently, the Californium Rare Isotope Breeder Upgrade (CARIBU) to the Argonne Tandem Linac Accelerator System (ATLAS) was commissioned and became available for production of rare isotopes. Currently, an electron cyclotron resonance ion source is used as a charge breeder for CARIBU beams. To further increase the intensity and improve the purity of neutron-rich ion beams accelerated by ATLAS, we are developing a high-efficiency charge breeder for CARIBU based on an electron beam ion source (EBIS). The CARIBU EBIS charge breeder will utilize the state-of-the-art EBIS technology recently developed at Brookhaven National Laboratory (BNL). The electron beam current density in the CARIBU EBIS trap will be significantly higher than that in existing operational charge-state breeders based on the EBIS concept. The design of the CARIBU EBIS charge breeder is nearly complete. Long-lead components of the EBIS such as a 6-T superconducting solenoid and an electron gun have been ordered with the delivery schedule in the fall of 2011. Measurements of expected breeding efficiency using the BNL Test EBIS have been performed using a Cs{sup +} surface ionization ion source for external injection in pulsed mode. In these experiments we have achieved {approx}70% injection/extraction efficiency and breeding efficiency into the most abundant charge state of {approx}17%.

  9. Development of electron beam ion source charge breeder for rare isotopes at Californium Rare Isotope Breeder Upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Kondrashev S.; Alessi J.; Dickerson, C.; Levand, A.; Ostroumov, P.N.; Pardo, R.C.; Savard, G.; Vondrasek, R.; Beebe, E.; Pikin, A.; Kuznetsov, G.I.; Batazova, M.A.

    2012-02-03

    Recently, the Californium Rare Isotope Breeder Upgrade (CARIBU) to the Argonne Tandem Linac Accelerator System (ATLAS) was commissioned and became available for production of rare isotopes. Currently, an electron cyclotron resonance ion source is used as a charge breeder for CARIBU beams. To further increase the intensity and improve the purity of neutron-rich ion beams accelerated by ATLAS, we are developing a high-efficiency charge breeder for CARIBU based on an electron beam ion source (EBIS). The CARIBU EBIS charge breeder will utilize the state-of-the-art EBIS technology recently developed at Brookhaven National Laboratory (BNL). The electron beam current density in the CARIBU EBIS trap will be significantly higher than that in existing operational charge-state breeders based on the EBIS concept. The design of the CARIBU EBIS charge breeder is nearly complete. Long-lead components of the EBIS such as a 6-T superconducting solenoid and an electron gun have been ordered with the delivery schedule in the fall of 2011. Measurements of expected breeding efficiency using the BNL Test EBIS have been performed using a Cs{sup +} surface ionization ion source for external injection in pulsed mode. In these experiments we have achieved {approx}70% injection/extraction efficiency and breeding efficiency into the most abundant charge state of {approx}17%.

  10. 17 CFR 256.403 - Depreciation and amortization expense.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Depreciation and amortization... UTILITY HOLDING COMPANY ACT OF 1935 Income and Expense Accounts § 256.403 Depreciation and amortization expense. This account shall include the amount of depreciation and amortization for all service plant,...

  11. 17 CFR 256.01-6 - Departmental classification required.

    Science.gov (United States)

    2010-04-01

    ... (CONTINUED) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 General Instructions § 256.01-6 Departmental classification required... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Departmental...

  12. Implementation of cryptographic hash function SHA256 in C++

    Science.gov (United States)

    Shrivastava, Akash

    2012-02-01

    This abstract explains the implementation of SHA Secure hash algorithm 256 using C++. The SHA-2 is a strong hashing algorithm used in almost all kinds of security applications. The algorithm consists of 2 phases: Preprocessing and hash computation. Preprocessing involves padding a message, parsing the padded message into m-bits blocks, and setting initialization values to be used in the hash computation. It generates a message schedule from padded message and uses that schedule, along with functions, constants, and word operations to iteratively generate a series of hash values. The final hash value generated by the computation is used to determine the message digest. SHA-2 includes a significant number of changes from its predecessor, SHA-1. SHA-2 consists of a set of four hash functions with digests that are 224, 256, 384 or 512 bits. The algorithm outputs a 256 bits message block with an internal state block of 256 bits and initial block size of 512 bits. Maximum message length in bit is generated is 2^64 -1, over all computed over a series of 64 rounds consisting or several operations such as and, or, Xor, Shr, Rot. The code will provide clear understanding of the hash algorithm and generates hash values to retrieve message digest.

  13. 17 CFR 256.926 - Employee pensions and benefits.

    Science.gov (United States)

    2010-04-01

    ... annuities for this purpose, when the service company has committed itself to a pension plan under which the... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Employee pensions and benefits... UTILITY HOLDING COMPANY ACT OF 1935 2. Expense § 256.926 Employee pensions and benefits. This...

  14. 17 CFR 256.181 - Unamortized debt expense.

    Science.gov (United States)

    2010-04-01

    ...) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 4. Deferred Debits § 256.181 Unamortized debt expense. This account shall... amount equitably over the life of the security. The amortization shall be on a monthly basis, and...

  15. 17 CFR 256.234 - Accounts payable to associate companies.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Accounts payable to associate... (CONTINUED) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 7. Current and Accrued Liabilities § 256.234 Accounts payable...

  16. 17 CFR 256.311 - Other service company property.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Other service company property... (CONTINUED) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 Service Company Property Accounts § 256.311 Other service...

  17. 17 CFR 256.930.1 - General advertising expenses.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false General advertising expenses... UTILITY HOLDING COMPANY ACT OF 1935 2. Expense § 256.930.1 General advertising expenses. This account shall include the cost of materials used and expenses incurred in advertising and related...

  18. 27 CFR 40.256 - Minimum manufacturing and activity requirements.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Minimum manufacturing and... Provisions Relating to Operations § 40.256 Minimum manufacturing and activity requirements. The minimum manufacturing and activity requirement prescribed in § 40.61(b) of this part is a continuing condition of...

  19. Etiological analysis of postmenopausal vaginal bleeding among 256 patients%绝经后阴道出血256例的病因分析

    Institute of Scientific and Technical Information of China (English)

    王丽君

    2011-01-01

    目的:探讨绝经后阴道出血的病因及相关因素.方法:对256例绝经后阴道出血病例的临床资料进行分析.结果:256例中,宫颈炎77例(占30.08%),阴道炎52例(20.31%),功能性子宫出血34例(13.28%),子宫内膜炎23例(8.98%),恶性肿瘤21例(8.20%),子宫内膜不典型增生20例(7.81%),子宫肌瘤16例(6.25%),宫内节育器10例(3.91%),外伤3例(1.17%).结论:炎症是绝经后出血的最主要原因;出血距绝经时间越长,恶性肿瘤的发生率越高.%Objective: To analysis the etiological factors of postmenopausal vaginal bleeding.Methods: 256 patients with postmenopausal vaginal bleeding were retrospectively analyzed.Results: The etiological factors of postmenopausal vaginal bleeding in 256 patients included cervieitis ( 30.08%, 77/256 ), vaginitis ( 20.31%,52/256), functional uterus bleeding ( 13.28%, 34/256 ), endometritis ( 8.98%, 23/256 ), malignant tumor ( 8.20% ,21/256 ) , atypical hyperplasia of endometrium ( 7.81% , 20/256 ), hysteromyoma ( 6.25% , 16/256 ) ,intrauterine contraceptive device (IUCD) ( 3.91%, 10/256 ), trauma ( 1.17 % ,3/256 ).Conclusion: Inflammation is the prior cause for postmenopausal vaginal bleeding.The longer time from menopause to postmenopausal vaginal bleeding, the higher the rate of malignant tumour.

  20. 17 CFR 256.108 - Accumulated provision for depreciation and amortization of service company property.

    Science.gov (United States)

    2010-04-01

    ... depreciation and amortization of service company property. 256.108 Section 256.108 Commodity and Securities... Accounts: Assets and Other Debit Accounts § 256.108 Accumulated provision for depreciation and amortization... 403, Depreciation and amortization expense. (b) At the time of retirement of depreciable...

  1. 30 CFR 256.68 - Effect of assignment of a particular tract.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Effect of assignment of a particular tract. 256.68 Section 256.68 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE... § 256.68 Effect of assignment of a particular tract. (a) When an assignment is made of all the...

  2. 40 CFR 256.64 - Requirements for public participation in the open dump inventory.

    Science.gov (United States)

    2010-07-01

    ... in the open dump inventory. 256.64 Section 256.64 Protection of Environment ENVIRONMENTAL PROTECTION... MANAGEMENT PLANS Public Participation § 256.64 Requirements for public participation in the open dump... classification of a facility as an open dump to the Federal Government. The State shall accomplish this...

  3. 17 CFR 256.01-12 - Compensation for use of capital.

    Science.gov (United States)

    2010-04-01

    ... capital. 256.01-12 Section 256.01-12 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... UTILITY HOLDING COMPANY ACT OF 1935 General Instructions § 256.01-12 Compensation for use of capital... of expenses plus reasonable compensation for necessary capital procured through the issuance...

  4. 17 CFR 256.01-2 - Application to service companies doing business with nonassociate companies.

    Science.gov (United States)

    2010-04-01

    ... companies doing business with nonassociate companies. 256.01-2 Section 256.01-2 Commodity and Securities... § 256.01-2 Application to service companies doing business with nonassociate companies. While this Uniform System of Accounts is designed for companies whose principal business is the performance...

  5. 6 CFR 25.6 - Procedures for designation of qualified anti-terrorism technologies.

    Science.gov (United States)

    2010-01-01

    ...-terrorism technologies. 25.6 Section 25.6 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REGULATIONS TO SUPPORT ANTI-TERRORISM BY FOSTERING EFFECTIVE TECHNOLOGIES § 25.6 Procedures for designation of qualified anti-terrorism technologies. (a) Application Procedure. Any person, firm or...

  6. 单向Hash函数SHA-256的研究与改进%One-way Hash function research and improved SHA-256

    Institute of Scientific and Technical Information of China (English)

    何润民

    2013-01-01

    This paper focuses on the study of the Hash SHA-256 algorithm,analyzes the logic and the compression function of the SHA-256 algorithm.On the basis of the study,it designs an improved Hash function SHA-256,using VC ++ development tools,completed the software implementation.It verifies the improved Hash function SHA-256 has better nonlinearity,one-way,collision resistance,randommess and avalanche effect by the theoretical analysis,realization of software for the string of text file Hash and comparison of the calculation results.%对Hash函数SHA-256进行了研究,分析了SHA-256的算法逻辑,以及它所采用的压缩函数的构造,在此基础上研究设计了一个改进的Hash函数SHA-256,应用VC++开发工具对改进的Hash函数SHA-256完成了软件实现.利用理论分析和实现软件对字符串、文本文件进行Hash计算结果的比较,结果证实改进的Hash函数具有更好的非线性性、单向性、抗碰撞性、伪随机性和雪崩效应.

  7. Low Power 256-bit Modified Carry Select Adder

    Directory of Open Access Journals (Sweden)

    P. Ramani

    2014-09-01

    Full Text Available Carry Select Adder (CSLA is one of the high speed adders used in many computational systems to perform fast arithmetic operations. When compared to earlier Ripple Carry Adder and Carry Look Ahead Adder, Regular CSLA (R-CSLA is observed to provide optimized results in terms of area. This study proposes an efficient method which replaces the RCA using BEC. The modified CSLA architecture has been developed using gate-level modification to significantly reduce the delay and power of the CSLA. Based on this modification 8-, 16-, 32-, 64- and 128-bit Square-Root CSLA (SQRT CSLA architecture have been developed and compared with the regular SQRT CSLA architecture. The proposed design for 256-bit has reduced power and delay as compared with the regular SQRT CSLA. Designs were developed using structural Verilog module and synthesized using Xilinx ISE simulator and the implementation is done in cadence RTL compiler using 0.18 µm technology. For 256-bit addition in this study, it is proposed to simple gate level modification which significantly reduces the power by 19.4% when compared with R-CSLA. The result analysis shows that the proposed architecture achieves two folded advantages in terms of delay and power.

  8. Modelo experimental do carcinossarcoma 256 de Walker em bexiga de ratos Experimental model of Walker 256 carcinosarcoma in rats bladder

    Directory of Open Access Journals (Sweden)

    Conceição Aparecida Dornelas

    2006-02-01

    Full Text Available OBJETIVO: Estudar um modelo animal para tumor de bexiga com Walker 256. MÉTODOS: Bexigas de ratos Wistar foram cateterizadas via uretral e lesão de parede vesical foi realizada por compressão extrínsica, com pequena pinça, após laparotomia. A seguir 0,3 ml de suspensão contendo 3 x 10(5 células viáveis de carcinossarcoma de Walker foram instiladas em cada bexiga. Os animais foram sacrificados após oito e 13 dias. RESULTADOS: O índice de pega do tumor foi de 100%. A média de sobrevida foi de 14,5 dias. CONCLUSÃO: O modelo estudado foi eficiente e poderá levar subsídios para o estudo experimental em tratamentos de carcinomas de bexiga localmente invasivos em ratos.PURPOSE: An animal model to study bladder tumor with Walker 256. METHODS: Bladders rats Wistar was catheterized via urethra and compression lesion of the wall bladder was realized with a little clamping after laparotomy. One total of the 0,3 ml suspension with 3 x 10(5 cels viable of the carcinossarcoma was instilled into each bladder. The animals were sacrificed after eight and 13 days. RESULTS: The index of tumor incidence was 100% and the average of surviving was 14,5 days. CONCLUSION: The model estudied was efficient and will can to take subsidy the study experiemental in treatment of local invasise bladder cancer.

  9. 人脑胶质瘤256层CT灌注成像%Perfusion 256-Slice CT Imaging of Human Gliomas

    Institute of Scientific and Technical Information of China (English)

    陆娜; Haleena Ramsahye; 冯晓源; 强金伟; 廖治河; 蒋玲

    2013-01-01

    Objective:To evaluate the feasibility of using perfusion 256-slice CT imaging in the examination of human gliomas and to investigate the perfusion characteristics of gliomas.Methods:From Jan 2010 to Feb 2012,among 55 subjects who underwent perfusion 256-slice CT imaging,there were 40 patients with gliomas(25 patients with high grade gliomas,15 patients with low grade gliomas) and 15 healthy volunteers served as controls.The raw data including cerebral blood flow(CBF),cerebral blood volume(CBV),mean transit time(MTT) and permeability surface-area product of region of interest(ROD were processed using CT perfusion software.The statistical analysis was performed to compare the difference among controls,low grade gliomas and high grade gliomas using ANOVA test.Results:A total of 40 patients with gliomas have been proved by the histopathological results.CBF,CBV and permeability surface-area product in high grade gliomas were (51.41 ± 11.60)mL/(100 g · min),(6.26 ± 1.67)mL/100 g and (5.71 ± 2.22)mL/(min · 100 g),respectively; in low grade gliomas they were (32.73 ± 7.06)mL/(100 g · min),(2.98 ± 0.73) mL/100 g and (2.33 ± 0.47) mL/(min · 100 g),respectively; and in controls they were (21.06 ± 2.06)mL/(100 g · min),(1.76 ± 0.17)mL/100 g and (0.90 ± 0.07)mL/(min · 100 g) respectively.Significant differences of CBF,CBV and permeability surface-area product were observed among high grade gliomas,low grade gliomas and controls(P all<0.01).There were no difference in MTT among 3 groups.When cutoff value of permeability surface-area product was 2.88 mL/(min · 100 g),the sensitivity and specificity were 96 % and 93 %.When cutoff value of CBV was 3.91 mL/100 g,the sensitivity and specificity were 92 % and 93 %.When cutoff value of CBF was 38.90 mL/(100g· min),the sensitivity and specificity were 92 % and 86 %.Conclusions:Perfusion 256-slice CT imaging can provide useful parameters for glioma hemodynamics.%目的:探讨人脑胶质瘤256层CT灌注

  10. 17 CFR 256.01-5 - Determination of service cost accounting.

    Science.gov (United States)

    2010-04-01

    ... accounting. 256.01-5 Section 256.01-5 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... accounting. Service at cost and fair allocation of costs require, first of all, an accurate accounting for the elements which make up the aggregate expense of conducting the business of the service company....

  11. 30 CFR 256.62 - Assignment of lease or interest in lease.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Assignment of lease or interest in lease. 256... § 256.62 Assignment of lease or interest in lease. This section explains how to assign record title and other interests in OCS oil and gas or sulphur leases. (a) MMS may approve the assignment to you of...

  12. 40 CFR 264.256 - Special requirements for ignitable or reactive waste.

    Science.gov (United States)

    2010-07-01

    ... reactive waste. 264.256 Section 264.256 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE... applicable requirements of 40 CFR part 268, and: (a) The waste is treated, rendered, or mixed before...

  13. 42 CFR 422.256 - Review, negotiation, and approval of bids.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Review, negotiation, and approval of bids. 422.256... Information and Plan Approval § 422.256 Review, negotiation, and approval of bids. (a) Authority. Subject to... submitted under § 422.252 and conduct negotiations with MA organizations regarding these bids (including...

  14. 42 CFR 441.256 - Additional condition for Federal financial participation (FFP).

    Science.gov (United States)

    2010-10-01

    ... participation (FFP). 441.256 Section 441.256 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT... financial participation (FFP). (a) FFP is not available in expenditures for any sterilization or... through November 2, 1982, FFP is available in expenditures for those services if the documentation...

  15. 17 CFR 256.01-3 - General structure of accounting system.

    Science.gov (United States)

    2010-04-01

    ... accounting system. 256.01-3 Section 256.01-3 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... accounting system. (a) The accounts provided herein are in two general categories: Balance sheet accounts and... account numbers in the Uniform System of Accounts for Public Utilities and Licensees (18 CFR Part 101)...

  16. 针对访问驱动cache攻击HC-256算法的改进%Improved algorithm for HC-256 to access-driven cache attack

    Institute of Scientific and Technical Information of China (English)

    郑继森; 谭晓青; 莫庆平; 贺婵

    2011-01-01

    In order to defense against the access-driven cache attack, this paper improved the stream cipher HC-256.Added full random sort algorithm to the HC-256, which disrupted the order of the tables P and Q.This paper used variable tables instead of ( fixed content) S-boxes, and it gave the adversary insecurity both about the input and the output of the tables.It defenses against the access-driven cache attack effectively.%为了使HC-256可以防御访问驱动cache攻击,对HC-256算法进行了改进.在HC-256中加入完全随机排序算法,对表P和表Q进行扰乱,这样使用变化的表代替固定的S盒,使得攻击者获得的输入和输出都是不安全的,有效地防御了此访问驱动cache攻击.

  17. Incidental sinus abnormalities in 256 patients referred for brain MRI

    Directory of Open Access Journals (Sweden)

    Ghanaati H

    2007-06-01

    Full Text Available Background: Imaging abnormalities in the paranasal sinuses are regularly noted as incidental findings on MRI, however, little is known about their prevalence in the Iranian population. The purpose of this study was to classify these findings in the paranasal sinuses as seen on MRI and to investigate the prevalence, according to site and type of paranasal abnormality. Methods: In this cross-sectional study, the T2-weighted axial MRI of 256 patients with diseases unrelated to their paranasal sinuses were reviewed between May 2002 and June 2003. The findings were categorized according to the anatomic location and the imaging characteristics of the abnormality. The abnormalities recorded included total sinus opacification, mucoperiosteal thickening >5mm, air fluid levels and retention cysts or polyps. Unilateral or bilateral involvement and septal deviation were also noted. A sinus was considered normal if it was fully aerated and no soft-tissue density was apparent within the cavity. Results: Among our cases, 111 (43.5% were male and 145 (56.5% were female. Of these patients, abnormalities in one or more of the sinus groups were found in 110 subjects (42.9%, 55.5% of which were male and 44.5% were female (P=0.001. Maxillary sinus abnormalities were observed in 66.4% of the patients, while ethmoid sinus abnormalities were found in 63.6%. Of the ethmoid abnormalities, 21% were found in the anterior section, 9% in the middle ethmoid, and 8% in the posterior ethmoid. The most common abnormality found was mucosal thickening. Among our cases, 23.4% had septal deviation, which was significantly higher among those with sinusitis (29% versus 19.1%; P<0.01. Of those patients with sinus involvement, 16% were involved in the sphenoid sinus and 5% in the frontal sinus. The results obtained from the patients with sinus abnormality revealed that 85% suffered from cough, nasal obstruction, runny nose, facial pain and post nasal discharge and 24% had been diagnosed

  18. High-Speed, Low Power 256 Channel Gamma Radiation Array Detector ASIC Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Building on prior success in detector electronics, we propose to design and fabricate a 256 channel readout ASIC for solid state gamma radiation array detectors...

  19. Nonlinear Phase Noise Compensation in Experimental WDM Systems with 256QAM

    DEFF Research Database (Denmark)

    Yankov, Metodi Plamenov; Da Ros, Francesco; Porto da Silva, Edson

    2016-01-01

    Nonlinear phase noise (NLPN) is studied in an experimental wavelength division multiplexed (WDM) system operating at 256QAM. Extremely narrow linewidth lasers (phase part of the nonlinear noise in a Raman amplified link. Based...

  20. Investigation of antioxidative and anticancer potentials of Streptomyces sp. MUM256 isolated from Malaysia mangrove soil

    Directory of Open Access Journals (Sweden)

    Tan Loh eTeng Hern

    2015-11-01

    Full Text Available A Streptomyces strain, MUM256 was isolated from Tanjung Lumpur mangrove soil in Malaysia. Characterization of the strain showed that it has properties consistent with those of the members of the genus Streptomyces. In order to explore the potential bioactivities, extract of the fermented broth culture of MUM256 was prepared with organic solvent extraction method. DPPH and SOD activity were utilized to examine the antioxidant capacity and the results have revealed the potency of MUM256 in superoxide anion scavenging activity in dose-dependent manner. The cytotoxicity of MUM256 extract was determined using cell viability assay against 8 different panels of human cancer cell lines. Among all the tested cancer cells, HCT116 was the most sensitive toward the extract treatment. At the highest concentration of tested extract, the result showed 2.3, 2.0 and 1.8 folds higher inhibitory effect against HCT116, HT29 and Caco-2 respectively when compared to normal cell line. This result has demonstrated that MUM256 extract was selectively cytotoxic towards colon cancer cell lines. In order to determine the constituents responsible for its bioactivities, the extract was then subjected to chemical analysis using GC-MS. The analysis resulted in the identification of chemical constituents including phenolic and pyrrolopyrazine compounds which may responsible for antioxidant and anticancer activities observed. Based on the findings of this study, the presence of bioactive constituents in MUM256 extract could be a potential source for the development of antioxidative and chemopreventive agents.

  1. PERBANDINGAN APLIKASI MENGGUNAKAN METODE CAMELLIA 128 BIT KEY DAN 256 BIT KEY

    Directory of Open Access Journals (Sweden)

    Lanny Sutanto

    2014-01-01

    Full Text Available The rapid development of the Internet today to easily exchange data. This leads to high levels of risk in the data piracy. One of the ways to secure data is using cryptography camellia. Camellia is known as a method that has the encryption and decryption time is fast. Camellia method has three kinds of scale key is 128 bit, 192 bit, and 256 bit.This application is created using the C++ programming language and using visual studio 2010 GUI. This research compare the smallest and largest key size used on the file extension .Txt, .Doc, .Docx, .Jpg, .Mp4, .Mkv and .Flv. This application is made to comparing time and level of security in the use of 128-bit key and 256 bits. The comparison is done by comparing the results of the security value of avalanche effect 128 bit key and 256 bit key.

  2. New related-key rectangle attacks on reduced AES-192 and AES-256

    Institute of Scientific and Technical Information of China (English)

    WEI YongZhuang; HU YuPu

    2009-01-01

    In this paper, we examine the security of reduced AES-192 and AES-256 against related-key rectangle attacks by exploiting the weakness in the AES key schedule. We find the following two new attacks: 9-round reduced AES-192 with 4 related keys, and 10-round reduced AES-256 with 4 related keys. Our results show that related-key rectangle attack with 4 related keys on 9-round reduced AES-192 requires a data complexity of about 2101 chosen plaintexts and a time complexity of about 2174.8 encryptions, and moreover, related-key rectangle attack with 4 related keys on 10-round reduced AES-256 requires a data complexity of about 297.5 chosen plaintexts and a time complexity of about 2254 encryptions. These attacks are the first known attacks on 9-round reduced AES-192 and 10-round reduced AES-256 with only 4 related keys. Furthermore, we give an improvement of the 10-round reduced AES-192 attack presented at FSE2007, which reduces both the data complexity and the time complexity.

  3. 42 CFR 447.256 - Procedures for CMS action on assurances and State plan amendments.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Procedures for CMS action on assurances and State... for Inpatient Hospital and Long-Term Care Facility Services Payment Rates § 447.256 Procedures for CMS action on assurances and State plan amendments. (a) Criteria for approval. (1) CMS approval action...

  4. 17 CFR 256.309 - Automobiles, other vehicles, and related garage equipment.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Automobiles, other vehicles... § 256.309 Automobiles, other vehicles, and related garage equipment. This account shall include the delivered cost of all service company owned automobiles, vans, trucks, and other vehicles used by...

  5. Low-Loss 256-Channel AWG Module with Monolithically Integrated Spot-Size Converters

    Institute of Scientific and Technical Information of China (English)

    M. Itoh; S. Kamei; M. Ishii; Y. Hida; T. Shibata; Y. Hibino

    2003-01-01

    We developed a compact fiber-pigtailed 256-channel AWG module with 1.5% △ waveguides.By monolithically integrating spot-size converters with input/output waveguides, we achieved a lowinsertion loss of 2.6-4.1 dB with a low background crosstalk of -40 dB.

  6. Low-Loss 256-Channel AWG Module with Monolithically Integrated Spot-Size Converters

    Institute of Scientific and Technical Information of China (English)

    M.; Itoh; S.; Kamei; M.; Ishii; Y.; Hida; T.; Shibata; Y.; Hibino

    2003-01-01

    We developed a compact fiber-pigtailed 256-channel AWG module with 1.5% A waveguides. By monolithically integrating spot-size converters with input/output waveguides, we achieved a low insertion loss of 2.6-4.1 dB with a low background crosstalk of-40 dB.

  7. Fast Facts: Recent Statistics from the Library Research Service, Numbers 256-265. February - November, 2008

    Science.gov (United States)

    Online Submission, 2008

    2008-01-01

    Issues 256 through 265 of "Fast Facts" from the Library Research Service present data collected from libraries in Colorado and throughout the nation. Topics addressed in these "Fast Facts" from 2008 include computer usage by public library patrons, Colorado summer reading programs, children's' use of public libraries, and the…

  8. Insertion sequence IS256 in canine pyoderma isolates of Staphylococcus pseudintermedius associated with antibiotic resistance.

    Science.gov (United States)

    Casagrande Proietti, P; Bietta, A; Coletti, M; Marenzoni, M L; Scorza, A V; Passamonti, F

    2012-06-15

    Staphylococcus pseudintermedius is the most frequent staphylococcal species isolated from canine pyoderma. The control of S. pseudintermedius infection is often difficult due to the expanded antimicrobial resistance phenotypes. Antibiotic resistance in staphylococcal pathogens is often associated to mobile genetic elements such as the insertion sequence IS256 that was first described as a part of the transposon Tn4001, which confers aminoglycoside resistance in Staphylococcus aureus and in Staphylococcus epidermidis. In this study a collection of 70 S. pseudintermedius isolates from canine pyoderma was used to investigate antimicrobial susceptibility to 15 antibiotics and the presence of IS256, not revealed in S. pseudintermedius yet. Antibiotic resistance profiling demonstrated that all S. pseudintermedius isolates had a multi-drug resistance phenotype, exhibiting simultaneous resistance to at least five antibiotics; indeed methicillin resistant S. pseudintermedius isolates were simultaneously resistant to at least nine antibiotics and all were also gentamicin resistant. PCR analyses revealed the presence of IS256 in 43/70 S. pseudintemedius isolates. The association between the presence of IS256 and the resistance was particularly significant for certain antibiotics: cefovecin, amikacin, gentamicin and oxacillin (χ(2)p-valuepseudintermedius isolates and its association with antibiotic resistance. Our findings suggest that S. pseudintermedius may acquire antibiotic resistance genes through mobile genetic elements which may play a predominant role in the dissemination of multi-drug resistance.

  9. 17 CFR 256.226 - Unamortized discount on long-term debt-debit.

    Science.gov (United States)

    2010-04-01

    ... COMMISSION (CONTINUED) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 6. Long-Term Debt § 256.226 Unamortized discount on.... The amortization shall be on a monthly basis, with the amounts thereof charged to account...

  10. 17 CFR 256.225 - Unamortized premium on long-term debt.

    Science.gov (United States)

    2010-04-01

    ... COMMISSION (CONTINUED) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 6. Long-Term Debt § 256.225 Unamortized premium on... distribute the amount equitably over the life of the security. The amortization shall be on a monthly...

  11. Genetic Fingerprinting of Wheat and Its Progenitors by Mitochondrial Gene orf256

    Directory of Open Access Journals (Sweden)

    Mona M. Elseehy

    2012-04-01

    Full Text Available orf256 is a wheat mitochondrial gene associated with cytoplasmic male sterility (CMS that has different organization in various species. This study exploited the orf256 gene as a mitochondrial DNA marker to study the genetic fingerprint of Triticum and Aegilops species. PCR followed by sequencing of common parts of the orf256 gene were employed to determine the fingerprint and molecular evolution of Triticum and Aegilops species. Although many primer pairs were used, two pairs of orf256 specific primers (5:-94/C: 482, 5:253/C: 482, amplified DNA fragments of 576 bp and 230 bp respectively in all species were tested. A common 500 bp of nine species of Triticum and Aegilops were aligned and showed consistent results with that obtained from other similar chloroplast or nuclear genes. Base alignment showed that there were various numbers of base substitutions in all species compared to S. cereal (Sc (the outgroup species. Phylogenetic relationship revealed similar locations and proximity on phylogenetic trees established using plastid and nuclear genes. The results of this study open a good route to use unknown function genes of mitochondria in studying the molecular relationships and evolution of wheat and complex plant genomes.

  12. 40 CFR 256.02 - Scope of the State solid waste management plan.

    Science.gov (United States)

    2010-07-01

    ...) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Purpose, General Requirements, Definitions § 256.02 Scope of the State solid waste management plan. (a)(1) The... plan shall consider the following aspects of solid waste management: (i) Resource conservation;...

  13. 32 CFR 256.9 - Real estate interests to be considered for clear zones and accident potential zone.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Real estate interests to be considered for clear zones and accident potential zone. 256.9 Section 256.9 National Defense Department of Defense (Continued....9 Real estate interests to be considered for clear zones and accident potential zone. (a) The...

  14. 40 CFR 256.26 - Requirement for schedules leading to compliance with the prohibition of open dumping.

    Science.gov (United States)

    2010-07-01

    ... compliance with the prohibition of open dumping. 256.26 Section 256.26 Protection of Environment... compliance with the prohibition of open dumping. In implementing the section 4005(c) prohibition on open dumping, the State plan shall provide that any entity which demonstrates that it has considered...

  15. 40 CFR 256.27 - Recommendation for schedules leading to compliance with the prohibition of open dumping.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommendation for schedules leading to compliance with the prohibition of open dumping. 256.27 Section 256.27 Protection of Environment... to compliance with the prohibition of open dumping. In reviewing applications for...

  16. Physical performance evaluation of a 256-slice CT-scanner for four-dimensional imaging.

    Science.gov (United States)

    Mori, Shinichiro; Endo, Masahiro; Tsunoo, Takanori; Kandatsu, Susumu; Tanada, Shuji; Aradate, Hiroshi; Saito, Yasuo; Miyazaki, Hiroaki; Satoh, Kazumasa; Matsushita, Satoshi; Kusakabe, Masahiro

    2004-06-01

    We have developed a prototype 256-slice CT-scanner for four-dimensional (4D) imaging that employs continuous rotations of a cone-beam. Since a cone-beam scan along a circular orbit does not collect a complete set of data to make an exact reconstruction of a volume [three-dimensional (3D) image], it might cause disadvantages or artifacts. To examine effects of the cone-beam data collection on image quality, we have evaluated physical performance of the prototype 256-slice CT-scanner with 0.5 mm slices and compared it to that of a 16-slice CT-scanner with 0.75 mm slices. As a result, we found that image noise, uniformity, and high contrast detectability were independent of z coordinate. A Feldkamp artifact was observed in distortion measurements. Full width at half maximum (FWHM) of slice sensitivity profiles (SSP) increased with z coordinate though it seemed to be caused by other reasons than incompleteness of data. With regard to low contrast detectability, smaller objects were detected more clearly at the midplane (z = 0 mm) than at z = 40 mm, though circular-band like artifacts affected detection. The comparison between the 16-slice and the 256-slice scanners showed better performance for the 16-slice scanner regarding the SSP, low contrast detectability, and distortion. The inferiorities of the 256-slice scanner in other than distortion measurement (Feldkamp artifact) seemed to be partly caused by the prototype nature of the scanner and should be improved in the future scanner. The image noise, uniformity, and high contrast detectability were almost identical for both CTs. The 256-slice scanner was superior to the 16-slice scanner regarding the PSF, though it was caused by the smaller transverse beam width of the 256-slice scanner. In order to compare both scanners comprehensively in terms of exposure dose, noise, slice thickness, and transverse spatial resolution, K=Dsigma2ha3 was calculated, where D was exposure dose (CT dose index), sigma was magnitude of

  17. 256例急性胰腺炎的心电图分析

    Institute of Scientific and Technical Information of China (English)

    吴梅丽; 李根武

    2004-01-01

    目的:分析急性胰腺炎(AP)患者心电图(ECG)的改变及其临床意义.方法:回顾性分析256例AP患者的ECG资料.结果:256例AP患者中有138例(53.9%)出现ECG异常.ECG异常主要表现为窦性心动过速、ST段降低和T波的改变等.结论:AP患者常伴有ECG的异常改变,ECG监测对判断病情发展及给予相应处理有帮助.

  18. Discovery of a 7.6-hour high-spin isomer of einsteinium-256

    CERN Document Server

    Lougheed, R W; Daniels, W R; Hoffman, D C; Jackson, S V; Landrum, J H; Starner, J W; Wilhelmy, J B

    1976-01-01

    A 7.6-hour, beta-emitting isomer of /sup 256/Es has been produced via the (t, p) reaction by bombarding /sup 254g/Es with 16-MeV tritons. No evidence for an alpha branch has been found. A number of gamma rays have been observed, on the basis of which a partial decay scheme is proposed. It is concluded that the isomer has spin 7 or 8. (2 refs).

  19. CHARACTERIZING THE COOL KOIs. V. KOI-256: A MUTUALLY ECLIPSING POST-COMMON ENVELOPE BINARY

    Energy Technology Data Exchange (ETDEWEB)

    Muirhead, Philip S.; Shporer, Avi; Becker, Juliette; Swift, Jonathan J.; Hinkley, Sasha; Pineda, J. Sebastian; Bottom, Michael; Baranec, Christoph; Riddle, Reed; Tendulkar, Shriharsh P.; Bui, Khanh [California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Vanderburg, Andrew [University of California, Berkeley, CA 94720 (United States); Lloyd, James P.; Fuller, Jim [Cornell University, Ithaca, NY 14850 (United States); Zhao, Ming [Department of Astronomy and Astrophysics, 525 Davey Laboratory, Pennsylvania State University, University Park, PA 16802 (United States); Howard, Andrew W. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Von Braun, Kaspar [NASA Exoplanet Science Institute, California Institute of Technology, MC 100-22, Pasadena, CA 91125 (United States); Boyajian, Tabetha S. [Department of Astronomy, Yale University, New Haven, CT 06511 (United States); Law, Nicholas [Dunlap Institute for Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto M5S 3H4, Ontario (Canada); Ramaprakash, A. N. [Inter-University Centre for Astronomy and Astrophysics, Ganeshkhind, Pune 411007 (India); and others

    2013-04-20

    We report that Kepler Object of Interest 256 (KOI-256) is a mutually eclipsing post-common envelope binary (ePCEB), consisting of a cool white dwarf (M{sub *} = 0.592 {+-} 0.089 M{sub Sun }, R{sub *} = 0.01345 {+-} 0.00091 R{sub Sun }, T{sub eff} = 7100 {+-} 700 K) and an active M3 dwarf (M{sub *} = 0.51 {+-} 0.16 M{sub Sun }, R{sub *} = 0.540 {+-} 0.014 R{sub Sun }, T{sub eff} = 3450 {+-} 50 K) with an orbital period of 1.37865 {+-} 0.00001 days. KOI-256 is listed as hosting a transiting planet-candidate by Borucki et al. and Batalha et al.; here we report that the planet-candidate transit signal is in fact the occultation of a white dwarf as it passes behind the M dwarf. We combine publicly-available long- and short-cadence Kepler light curves with ground-based measurements to robustly determine the system parameters. The occultation events are readily apparent in the Kepler light curve, as is spin-orbit synchronization of the M dwarf, and we detect the transit of the white dwarf in front of the M dwarf halfway between the occultation events. The size of the white dwarf with respect to the Einstein ring during transit (R{sub Ein} = 0.00473 {+-} 0.00055 R{sub Sun }) causes the transit depth to be shallower than expected from pure geometry due to gravitational lensing. KOI-256 is an old, long-period ePCEB and serves as a benchmark object for studying the evolution of binary star systems as well as white dwarfs themselves, thanks largely to the availability of near-continuous, ultra-precise Kepler photometry.

  20. Characterizing the Cool KOIs. V. KOI-256: A Mutually Eclipsing Post-Common Envelope Binary

    CERN Document Server

    Muirhead, Philip S; Shporer, Avi; Becker, Juliette; Swift, Jonathan J; Lloyd, James P; Fuller, Jim; Zhao, Ming; Hinkley, Sasha; Pineda, J Sebastian; Bottom, Michael; Howard, Andrew W; von Braun, Kaspar; Boyajian, Tabetha S; Law, Nicholas; Baranec, Christoph; Riddle, Reed; Ramaprakash, A N; Tendulkar, Shriharsh P; Bui, Khanh; Burse, Mahesh; Chordia, Pravin; Das, Hillol; Dekany, Richard; Punnadi, Sujit; Johnson, John Asher; 10.1088/0004-637X/767/2/111

    2013-01-01

    We report that Kepler Object of Interest 256 (KOI-256) is a mutually eclipsing post-common envelope binary (ePCEB), consisting of a cool white dwarf (M = 0.592 +/- 0.089 MSun, R = 0.01345 +/- 0.00091 RSun, Teff = 7100 +/- 700 K) and an active M3 dwarf (M = 0.51 +/- 0.16 MSun, R = 0.540 +/- 0.014 RSun, Teff = 3450 +/- 50 K) with an orbital period of 1.37865 +/- 0.00001 days. KOI-256 is listed as hosting a transiting planet-candidate by Borucki et al. and Batalha et al.; here we report that the planet-candidate transit signal is in fact the occultation of a white dwarf as it passes behind the M dwarf. We combine publicly-available long- and short-cadence Kepler light curves with ground-based measurements to robustly determine the system parameters. The occultation events are readily apparent in the Kepler light curve, as is spin-orbit synchronization of the M dwarf, and we detect the transit of the white dwarf in front of the M dwarf halfway between the occultation events. The size of the white dwarf with respe...

  1. Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer rats.

    Science.gov (United States)

    Mao-Ying, Qi-Liang; Wang, Xiao-Wei; Yang, Chang-Jiang; Li, Xiu; Mi, Wen-Li; Wu, Gen-Cheng; Wang, Yan-Qing

    2012-05-20

    It has been reported that remarkable and sustained activation of astrocytes and/or microglia occurs in cancer induced pain (CIP), which is different from neuropathic and inflammatory pain. The present study was designed to investigate the role of spinal Toll-like receptor 4 (TLR4) induced glial neuroinflammation in cancer induced pain using a modified rat model of bone cancer. The rat model of CIP consisted of unilateral intra-tibial injection with Walker 256 mammary gland carcinoma. Nine days after Walker 256 inoculation, a robust activation of both astrocytes and microglia in bilateral spinal dorsal horn was observed together with significant bilateral mechanical allodynia. This neuroinflammation was characterized by enhanced immunostaining of both glial fibrillary acidic protein (GFAP, astrocyte marker) and OX-42 (microglia marker), and an elevated level of IL-1β, IL-6 and TNF-α mRNA. I.t. administration of fluorocitrate (an inhibitor of glial metabolism, 1 nmol) or minocycline (an inhibitor of microglia, 100 μg) has significant anti-allodynic effects on day 12 after Walker 256 inoculation. Naloxone (a nonstereoselective TLR4 signaling blocker, 60 μg, i.t.) also significantly alleviated mechanical allodynia and simultaneously blocked the increased inflammatory cytokine mRNA. The results suggested that spinal TLR4 might play an important role in the sustained glial activation that critically contributed to the robust and sustained spinal neuroinflammation in CIP. This result could potentially help clinicians and researchers to better understand the mechanism of complicated cancer pain.

  2. 125kHz可读写AT88RF256-12芯片简介

    Institute of Scientific and Technical Information of China (English)

    中山市达华智能科技有限公司技术部

    2004-01-01

    芯片简介:AT88RF256-12卡是美国ATMEL公司出品的一款基于125kHz频率工作的RFID感应卡芯片,数据存储空间为256位,有密码设置和写保护,是一款适合普通场合使用而又廉价的低频、加密、可读写ID卡,AT88RF256-12在低端市场上有着很大的应用前景。

  3. Californium Recovery from Palladium Wire

    Energy Technology Data Exchange (ETDEWEB)

    Burns, Jon D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2014-08-01

    The recovery of 252Cf from palladium-252Cf cermet wires was investigated to determine the feasibility of implementing it into the cermet wire production operation at Oak Ridge National Laboratory’s Radiochemical Engineering Development Center. The dissolution of Pd wire in 8 M HNO3 and trace amounts of HCl was studied at both ambient and elevated temperatures. These studies showed that it took days to dissolve the wire at ambient temperature and only 2 hours at 60°C. Adjusting the ratio of the volume of solvent to the mass of the wire segment showed little change in the kinetics of dissolution, which ranged from 0.176 mL/mg down to 0.019 mL/mg. A successful chromatographic separation of 153Gd, a surrogate for 252Cf, from Pd was demonstrated using AG 50x8 cation exchange resin with a bed volume of 0.5 mL and an internal diameter of 0.8 cm.

  4. A Passive NCITS 256 UHF RFID Transponder%一种NCITS 256协议超高频无源射频识别标签

    Institute of Scientific and Technical Information of China (English)

    刘忠奇; 孙旭光; 白蓉蓉; 张春; 李永明; 王志华

    2008-01-01

    设计了一种符合NCITS 256协议的无源超高频射频识别标签.标签携带2kbit的标准商用EEPROM.在读卡器发射功率为915MHz 4W EIRP的情况下,芯片的读距离为1.5m,写距离为0.3m.芯片在SMIC 0.18μm EEPROM CMOS工艺下流片实现,面积为1mm×1mm.标签使用Dickson倍压电路从读卡器发射的电磁波中提取能量.Dickson倍压电路使用肖特基管实现,转换效率为25%.%This paper presents a passive UHF radio frequency identification (RFID) transponder with 2k bit standard commercial EEPROM in compliance with the NCITS 256 protocol. The communication range is 1.5m for the read operation and 0.3m for the write operation with 4W effective isotropic radiated power (EIRP) at 915MHz. The integrated IC is implemented in SMIC 0.18μm EEPROM CMOS technology. The die size is 1mm × 1mm. The energy of the tag is harvested from RF electromagnetic waves transmitted by the reader with the help of a Schottky diode rectifier and achieves 25% power efficiency.

  5. Diagnostic accuracy of prospective ECG gated coronary computed tomography on a 256 slices scanner: Daily practice experience

    Directory of Open Access Journals (Sweden)

    Ahmed M. Fareed

    2014-03-01

    Conclusions: In a highly prevalence diseased population, prospective ECG-gated CTCA using 256-slice scanner is highly accurate for detection and quantification of the degree of coronary luminal stenosis in comparison to ICA.

  6. Naringin Inhibits Tumor Growth And Reduces Interleukin-6 And Tumor Necrosis Factor α Levels In Rats With Walker 256 Carcinosarcoma

    OpenAIRE

    Camargo C.A.; Gomes-Marcondes M.C.C.; Wutzki N.C.; Aoyama H.

    2012-01-01

    The flavonoid naringin is a polyphenolic compound that naturally occurs in citrus. Patients with cancer generally present features of malnutrition and cachexia. Levels of the proinflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) are raised in patients with cancer. This study was designed to analyze the in vivo effect of naringin in the therapeutic treatment of rats bearing Walker 256 carcinosarcoma (W256). Rats were treated intraperitoneally with different doses o...

  7. The influence of septal lesions on sodium and water retention induced by Walker 256 tumor

    Directory of Open Access Journals (Sweden)

    F. Guimarães

    1999-03-01

    Full Text Available In the course of studies on the effects of septal area lesions on neuroimmunomodulation and Walker 256 tumor development, it was observed that tumor-induced sodium and water retention was less marked in lesioned than in non-lesioned rats. In the present study possible mechanisms involved in this phenomenon were investigated. The experiments were performed in septal-lesioned (LW; N = 15 and sham-operated (SW; N = 7 8-week-old male Wistar rats, which received multifocal simultaneous subcutaneous (sc inoculations of Walker 256 tumor cells about 30 days after the stereotaxic surgery. Control groups (no tumor, sham-operated food-restricted (SFR, N = 7 and lesioned food-restricted (LFR, N = 10 were subjected to a feeding pattern similar to that observed in tumor-bearing animals. Multifocal inoculation of Walker 256 tumor rapidly induces anorexia, which is paradoxically accompanied by an increase in body weight, as a result of renal Na+ and fluid retention. These effects of the tumor were also seen in LW rats, although the rise in fractional sodium balance during the early clinical period was significantly smaller than in SW rats (day 4: SW = 47.6 ± 6.4% and LW = 13.8 ± 5.2%; day 5: SW = 57.5 ± 3.5% and LW = 25.7 ± 4.8%; day 6: SW = 54.4 ± 3.8% and LW = 32.1 ± 4.4%; P<0.05, suggesting a temporary reduction in tumor-induced sodium retention. In contrast, urine output was significantly reduced in SW rats and increased in LW rats (LW up to -0.85 and SW up to 4.5 ml/100 g body weight, with no change in osmolar excretion. These temporary changes in the tumor's effects on LW rats may reflect a "reversal" of the secondary central antidiuretic response induced by the tumor (from antidiuretic to diuretic.

  8. Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer rats

    Directory of Open Access Journals (Sweden)

    Mao-Ying Qi-Liang

    2012-05-01

    Full Text Available Abstract It has been reported that remarkable and sustained activation of astrocytes and/or microglia occurs in cancer induced pain (CIP, which is different from neuropathic and inflammatory pain. The present study was designed to investigate the role of spinal Toll-like receptor 4 (TLR4 induced glial neuroinflammation in cancer induced pain using a modified rat model of bone cancer. The rat model of CIP consisted of unilateral intra-tibial injection with Walker 256 mammary gland carcinoma. Nine days after Walker 256 inoculation, a robust activation of both astrocytes and microglia in bilateral spinal dorsal horn was observed together with significant bilateral mechanical allodynia. This neuroinflammation was characterized by enhanced immunostaining of both glial fibrillary acidic protein (GFAP, astrocyte marker and OX-42 (microglia marker, and an elevated level of IL-1β, IL-6 and TNF-α mRNA. I.t. administration of fluorocitrate (an inhibitor of glial metabolism, 1 nmol or minocycline (an inhibitor of microglia, 100 μg has significant anti-allodynic effects on day 12 after Walker 256 inoculation. Naloxone (a nonstereoselective TLR4 signaling blocker, 60 μg, i.t. also significantly alleviated mechanical allodynia and simultaneously blocked the increased inflammatory cytokine mRNA. The results suggested that spinal TLR4 might play an important role in the sustained glial activation that critically contributed to the robust and sustained spinal neuroinflammation in CIP. This result could potentially help clinicians and researchers to better understand the mechanism of complicated cancer pain.

  9. Modelo experimental de tumor na cavidade oral de ratos com carcinossarcoma de Walker 256 Experimental model of Walker 256 carcinosarcoma developed in the oral cavity of rats

    Directory of Open Access Journals (Sweden)

    Ana Paula Negreiros Nunes Alves

    2004-08-01

    Full Text Available OBJETIVO: Estabelecer um modelo experimental de desenvolvimento tumoral na cavidade oral de ratos, permitindo, assim, o estudo da osteólise induzida pelo tumor nos ossos do complexo maxilomandibular como também nas estruturas dentais, através da caracterização histomorfológica da reabsorção óssea e dentária. MÉTODOS: Uma suspensão de células tumorais (0,1mL do Carcinossarcoma de Walker 256, na concentração de 10(6 células/mL foi implantado na cavidade alveolar de ratos previamente aberta por exodontia. Os animais foram observados durante 12 (doze dias consecutivos para determinação da curva de peso corpóreo, sendo posteriormente sacrificados e as mandíbulas removidas para exames radiográfico e histológico. RESULTADOS: No exame radiográfico foi verificada área lítica, sem evidência de reparo, na região dos alvéolos. No exame microscópico foi identificada infiltração óssea, periférica e central, de pequenas células hipercromáticas e pleomórficas, com leve infiltrado inflamatório mononuclear associado e áreas de necrose. O índice de pega foi de 100%. CONCLUSÃO: O modelo animal de invasão óssea, do tumor de Walker na cavidade oral, possibilita a avaliação in vivo de drogas antitumorais e esquemas terapêuticos no tratamento do câncer bucal.PURPOSE: To estabilish an experimental model of tumor development in the oral cavity of rats, that would enable to study the tumor-induced autolysis in the maxillomandibular bone complex as well as of the dental structures, through histomorphological characterization of bone and dental resorption. METHODS: Walker 256 carcinossarcoma cell suspension (0,1 mL containing 10(6 cell/mL was implanted in the alveoli of first and second molars. The animals were observed during twelve consecutive days and the body weigth were determined. Later, the animals were sacrificed and their mandibles removed to radiographic and hystologic analysis. RESULTS: The radiographic image

  10. Treatment of 256 cases of Osteoarthritis of Knee Joint with Guo Jianhua's Four-step Therapy

    Institute of Scientific and Technical Information of China (English)

    Liu Yusong; Guo Liang; Ma Shanzhi; Zhu Hanting

    2008-01-01

    @@ 256 cases of osteoarthritis of knee joint were treated with Professor Guo Jianhua's four-step therapy,i.e.acupuncture at five points in the knee to remove obstruction of collaterals and stop pain,massotherapy to separate adhesion and relieve spasm,fumigation and steaming with hot decoction to promote blood circulation and expel swelling,and functional exercises to consolidate the therapeutic effects.121 cases were cured,117 cases markedly effective,and 18 cases ineffective,with a total effective rate of 92.97%.

  11. 混合AM-VSB/256QAM/Internet的同步传输系统

    Institute of Scientific and Technical Information of China (English)

    孟文杰

    2004-01-01

    本文叙述在校园中经现有多模光纤(MMF)同步传输1556nm下行CATV模拟视频、256QAM数字TV和Internet访问信号以及1310nm上行Internet访问信号的情况.这种技术使用现有的多模光纤使模拟和数字视频传输、千兆位以太网以及Internet接入教室成为可能.这种系统具有简单和费用低的特殊优点.

  12. 地塞米松对大鼠 Walker 256乳腺癌骨转移癌痛的作用%Effect of dexamethasone on rat bone metastasis pain induced by Walker 256 mammary gland carcinoma cells

    Institute of Scientific and Technical Information of China (English)

    张凡; 李毅; 丁杰; 张海林

    2015-01-01

    Objective To establish a rat model of bone metastasis pain induced by Walker 256 mammary gland carcinoma cells and observe the effect of dexamethasone on bone cancer pain. Methods Ascitic tumour cells were made from Walker 256 mammary gland carcinoma cells injected to tibia of rats.Then,the withdrawal threshold to mechanical stimulus and withdrawal time in response to radiant thermal stimulus were tested before and after operation.Results The withdrawal threshold to mechanical stimulus and withdrawal time in response to radiant thermal stimulus were significantly reduced in the tibia bone inoculated with Walker 256 cells.The pathology results showed the evidence of tibia bone structure was destructed by tumor.It is suggested that the model of bone metastasis pain induced by Walker 256 mammary gland carcinoma cell was successfully established.Dexamethasone (5 mg/kg ) elevated withdrawal threshold to mechanical stimulus in rat model of bone metastasis pain induced by Walker 256 mammary gland carcinoma cell.Conclusion Dexamethasone could alleviate bone cancer pain.%目的:建立大鼠 Walker 256乳腺癌骨转移癌痛模型,观察地塞米松对骨转移癌疼痛痛阈的影响。方法制备 Walker 256乳腺癌细胞的大鼠腹腔积液瘤细胞,将其注射入大鼠胫骨,测量术前及术后机械刺痛阈和辐射热痛阈。结果接种 Walker 256乳腺癌大鼠术侧机械刺激痛觉和辐射热痛觉阈值显著降低,且病理学结果显示骨质受到肿瘤破坏,提示 Walker 256大鼠乳腺癌骨转移癌疼痛模型成功建立。地塞米松(5 mg/kg)能够显著提高骨转移癌疼痛模型刺痛痛阈。结论地塞米松能够缓解大鼠骨转移癌疼痛。

  13. 技嘉GV-RX165P256D-RH显卡

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    技嘉GV-RX165P256D-RH基于ATi X1650 Pro核心.核心代号RV530LE.核心频率590MHz。显存部分采用四颗英飞凌编号为HYB18H512321AF-14的显存颗粒.从编号上看.单颗显存为64MB/32bit规格.组成了256MB/128bit的显存系统。显存的额定工作频率是1.4GHz.和显卡设定的默认工作频率一致.所以显存在超频方面不具备太大的超频潜力.不过相对于目前市场上其他的X1650 Pro系列显卡.显存频率能达到1.4GHz.已经占有一定优势了。

  14. Structural Variations of Human Glucokinase Glu256Lys in MODY2 Condition Using Molecular Dynamics Study

    Directory of Open Access Journals (Sweden)

    Nanda Kumar Yellapu

    2013-01-01

    Full Text Available Glucokinase (GK is the predominant hexokinase that acts as glucose sensor and catalyses the formation of Glucose-6-phosphate. The mutations in GK gene influence the affinity for glucose and lead to altered glucose levels in blood causing maturity onset diabetes of the young type 2 (MODY2 condition, which is one of the prominent reasons of type 2 diabetic condition. In view of the importance of mutated GK resulting in hyperglycemic condition, in the present study, molecular dynamics simulations were carried out in intact and 256 E-K mutated GK structures and their energy values and conformational variations were correlated. Energy variations were observed in mutated GK (3500 Kcal/mol structure with respect to intact GK (5000 Kcal/mol, and it showed increased γ-turns, decreased β-turns, and more helix-helix interactions that affected substrate binding region where its volume increased from 1089.152 Å2 to 1246.353 Å2. Molecular docking study revealed variation in docking scores (intact = −12.199 and mutated = −8.383 and binding mode of glucose in the active site of mutated GK where the involvement of A53, S54, K56, K256, D262 and Q286 has resulted in poor glucose binding which probably explains the loss of catalytic activity and the consequent prevailing of high glucose levels in MODY2 condition.

  15. Walker 256 Tumor Growth Suppression by Crotoxin Involves Formyl Peptide Receptors and Lipoxin A4

    Science.gov (United States)

    Brigatte, Patrícia; Faiad, Odair Jorge; Ferreira Nocelli, Roberta Cornélio; Landgraf, Richardt G.; Palma, Mario Sergio; Cury, Yara; Curi, Rui; Sampaio, Sandra Coccuzzo

    2016-01-01

    We investigated the effects of Crotoxin (CTX), the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, on Walker 256 tumor growth, the pain symptoms associated (hyperalgesia and allodynia), and participation of endogenous lipoxin A4. Treatment with CTX (s.c.), daily, for 5 days reduced tumor growth at the 5th day after injection of Walker 256 carcinoma cells into the plantar surface of adult rat hind paw. This observation was associated with inhibition of new blood vessel formation and decrease in blood vessel diameter. The treatment with CTX raised plasma concentrations of lipoxin A4 and its natural analogue 15-epi-LXA4, an effect mediated by formyl peptide receptors (FPRs). In fact, the treatment with Boc-2, an inhibitor of FPRs, abolished the increase in plasma levels of these mediators triggered by CTX. The blockage of these receptors also abolished the inhibitory action of CTX on tumor growth and blood vessel formation and the decrease in blood vessel diameter. Together, the results herein presented demonstrate that CTX increases plasma concentrations of lipoxin A4 and 15-epi-LXA4, which might inhibit both tumor growth and formation of new vessels via FPRs. PMID:27190493

  16. 256例急诊头晕患者临床特点分析%Clinical Characteristics Analysis of 256 Emergency Dizzy Patients

    Institute of Scientific and Technical Information of China (English)

    李渊; 姚丹林

    2016-01-01

    Objective:To explore the causes of emergency dizziness,discuss the clinical characteristics and improve the diagnostic efficiency. Method:The clinical data of 256 dizziness patients in our emergency department from January 2014 to December 2014 were included,they were divided into the elder group and non-elder group,the etiology and clinical characteristics of emergency dizziness were analyzed.Result:The main causes in non-elder group was BPPV(52.7%),the main causes in elder group was PCI(41.7%)and other central nervous system diseases.Different age groups in transcranial doppler ultrasound(TCD) of the changes in the blood flow were compared,the differences were statistically significant(P<0.05).Conclusion:Emergency dizziness etiology is complex,clinical manifestations of a variety of young and middle-aged dizziness patients first consider BPPV,mental factors and hypertension and so on.Elderly patients with dizziness mainly after the circulation ischemia(PCI) and other central nervous system diseases,and in the TCD examination and more with abnormal blood flow.%目的:分析急诊头晕患者的病因,探讨其临床特点,提高临床诊断水平。方法:收集2014年1-12月于笔者所在医院急诊科就诊的256例头晕患者的临床资料,将患者分为老年组和非老年组,分析急诊头晕的病因与临床特点。结果:非老年组以良性位置性眩晕(BPPV)发病率最高,老年组以后循环缺血(PCI)等中枢神经系统病变常见。不同年龄组在经颅多普勒超声(TCD)检查中血流变化情况比较,差异均有统计学意义(P<0.05)。结论:急诊头晕病因复杂,临床表现多样。青中年头晕患者首先考虑BPPV、精神因素及高血压病等。老年头晕患者主要以后循环缺血等中枢系统疾病为主,且在TCD检查中多伴有血流速度异常。

  17. Simulation and Design of 256 QAM Modulation Based on SDR%基于软件无线电的256QAM调制端的仿真与设计

    Institute of Scientific and Technical Information of China (English)

    曹扬; 周胜源

    2014-01-01

    在现代通信高速发展的今天,如何提高频谱利用率成为人们关注的焦点.QAM调制信号由于其较高的频带利用率而得到越来越广泛的应用.旨在采用System Generator仿真软件对256QAM进行模型化仿真验证,通过其仿真的图形分析其结果的正确性,实现对256QAM的仿真与设计.

  18. [Genetic algorithm application to multi-focus patterns of 256-element phased array for focused ultrasound surgery].

    Science.gov (United States)

    Xu, Feng; Wan, Mingxi; Lu, Mingzhu

    2008-10-01

    The genetic optimal algorithm and sound field calculation approach for the spherical-section phased array are presented in this paper. The in-house manufactured 256-element phased array focused ultrasound surgery system is briefly described. The on-axis single focus and off-axis single focus are simulated along with the axis-symmetric six-focus patter and the axis-asymmetric four-focus pattern using a 256-element phased array and the genetic optimal algorithm and sound field calculation approach. The experimental results of the described 256-element phased array focused ultrasound surgery system acting on organic glass and phantom are also analyzed. The results of the simulations and experiments confirm the applicability of the genetic algorithm and field calculation approaches in accurately steering three dimensional foci and focus.

  19. Design of a homogeneous subcritical nuclear reactor based on thorium with a source of californium 252; Diseno de un reactor nuclear subcritico homogeneo a base de Torio con una fuente de Californio 252

    Energy Technology Data Exchange (ETDEWEB)

    Delgado H, C. E.; Vega C, H. R. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas, Zac. (Mexico); Sajo B, L., E-mail: ce_delgado89@hotmail.com [Universidad Simon Bolivar, Laboratorio de Fisica Nuclear, Apdo. 89000, 1080A Caracas (Venezuela, Bolivarian Republic of)

    2015-10-15

    Full text: One of the energy alternatives to fossil fuels which do not produce greenhouse gases is the nuclear energy. One of the drawbacks of this alternative is the generation of radioactive wastes of long half-life and its relation to the generation of nuclear materials to produce weapons of mass destruction. An option to these drawbacks of nuclear energy is to use Thorium as part of the nuclear fuel which it becomes in U{sup 233} when capturing neutrons, that is a fissile material. In this paper Monte Carlo methods were used to design a homogeneous subcritical reactor based on thorium. As neutron reflector graphite was used. The reactor core is homogeneous and is formed of 70% light water as moderator, 12% of enriched uranium UO{sub 2}(NO{sub 3}){sub 4} and 18% of thorium Th(NO{sub 3}){sub 4} as fuel. To start the nuclear fission chain reaction an isotopic source of californium 252 was used with an intensity of 4.6 x 10{sup 7} s{sup -1}. In the design the value of the effective multiplication factor, whose value turned out k{sub eff} <1 was calculated. Also, the neutron spectra at different distances from the source and the total fluence were calculated, as well as the values of the ambient dose equivalent in the periphery of the reactor. (Author)

  20. Manganese determination om minerals by activation analysis, using the californium-252 as a neutron source; Determinacao de manganes em minerios, por analise por ativacao, usando californio-252 como fonte de neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Cardoso, Antonio

    1976-07-01

    Neutron Activation Analysis, using a Californium-252 neutron source, has been applied for the determination of manganese in ores such as pyrolusite, rodonite (manganese silicate)' and blending used in dry-batteries The favorable nuclear properties of manganese, such as high thermal neutron cross-section for the reaction {sup 55}Mn (n.gamma){sup 56} Mn, high concentration of manganese in the matrix and short half - life of {sup 56}Mn, are an ideal combination for non-destructive analysis of manganese in ores. Samples and standards of manganese dioxide were irradiated for about 20 minutes, followed by a 4 to 15 minutes decay and counted in a single channel pulse-height discrimination using a NaI(Tl) scintillation detector. Counting time was equal to 10 minutes. The interference of nuclear reactions {sup 56}Fe(n,p){sup 56}Mn and {sup 59} Co (n, {alpha}){sup 56} were studied, as well as problems in connection with neutron shadowing during irradiation, gamma-rays attenuation during counting and influence of granulometry of samples. One sample,was also analysed by wet-chemical method (sodium bismuthate) in order to compare results. As a whole, i t was shown that the analytical method of neutron activation for manganese in ores and blending, is a method simple, rapid and with good precision and accuracy. (author)

  1. 华硕Extreme N6600/TD/256M显卡

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    近日华硕发布一款中端显卡Extreme N6600/TD/256M。产品采用了NVIDIA的全新GeForce6600GPU,核心频率为300MHz。显存频率为500MHz.采用PCI-E接口。并具有华硕特有的Game Face Live和Video Security Online功能。可以支持最多8个视频窗口.通过Webcam在游戏中直接和最多8人进行交流Video Security Online通过摄像头或小型摄影机可以监控可视区域内的任何微小变化,如有不明身份者进入监控区域自动发出警报。

  2. A 256-TES Array for the Detection of CMB B-Mode Polarisation

    Science.gov (United States)

    Perbost, C.; Marnieros, S.; Bélier, B.; Piat, M.; Prêle, D.; Voisin, F.; Decourcelle, T.

    2016-08-01

    As part of the Q&U Bolometric Interferometer for Cosmology instrument targeting the cosmic microwave background primordial B-modes, two kilo-pixel focal planes have been designed for a NEP of ˜ 3 × 10^{-17} W√{Hz} adapted for ground-based observations. Those pixels are transition edge sensors (TESs) made of voltage-biased NbSi thin films with a critical temperature T_c ˜ 400 mK and TiV absorbing grids. The TESs are coupled to a time-domain multiplexed electronics based on superconducting quantum interference devices and an additional SiGe cryogenic integrated circuit which provides a second multiplexing stage. In this paper, we briefly discuss the instrumental context of a quarter of focal plane (a 256-TES sub-array). Then, we present its typical manufacturing process and first test results at cryogenic temperature.

  3. Radiation dose to patients and image quality evaluation from coronary 256-slice computed tomographic angiography

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Liang-Kuang [Department of Radiology, Shin Kong Wu Ho-Su Memorial Hospital, Taiwan (China); College of Medicine, Fu Jen Catholic University, Taiwan (China); Department of Radiological Technology, Yuan Pei University, Taiwan (China); Wu, Tung-Hsin [Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, 155 Li-Nong St., Section 2, Taipei 112, Taiwan (China); Yang, Ching-Ching [Department of Radiological Technology, Tzu Chi College of Technology, Hualien, Taiwan (China); Tsai, Chia-Jung [Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, 155 Li-Nong St., Section 2, Taipei 112, Taiwan (China); Lee, Jason J.S., E-mail: jslee@ym.edu.t [Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, 155 Li-Nong St., Section 2, Taipei 112, Taiwan (China)

    2010-07-21

    The aim of this study is to assess radiation dose and the corresponding image quality from suggested CT protocols which depends on different mean heart rate and high heart rate variability by using 256-slice CT. Fifty consecutive patients referred for a cardiac CT examination were included in this study. All coronary computed tomographic angiography (CCTA) examinations were performed on a 256-slice CT scanner with one of five different protocols: retrospective ECG-gating (RGH) with full dose exposure in all R-R intervals (protocol A), RGH of 30-80% pulsing window with tube current modulation (B), RGH of 78{+-}5% pulsing window with tube current modulation (C), prospective ECG-triggering (PGT) of 78% R-R interval with 5% padding window (D) and PGT of 78% R-R interval without padding window (E). Radiation dose parameters and image quality scoring were determined and compared. In this study, no significant differences were found in comparison on image quality of the five different protocols. Protocol A obtained the highest radiation dose comparing with those of protocols B, C, D and E by a factor of 1.6, 2.4, 2.5 and 4.3, respectively (p<0.001), which were ranged between 2.7 and 11.8 mSv. The PGT could significantly reduce radiation dose delivered to patients, as compared to the RGH. However, the use of PGT has limitations and is only good in assessing cases with lower mean heart rate and stable heart rate variability. With higher mean heart rate and high heart rate variability circumstances, the RGH within 30-80% of R-R interval pulsing window is suggested as a feasible technique for assessing diagnostic performance.

  4. Full-duplex transmission of 256-QAM WiMAX signals over an 80-km long-reach PON

    DEFF Research Database (Denmark)

    Prince, Kamau; Osadchiy, Alexey Vladimirovich; Tafur Monroy, Idelfonso

    2009-01-01

    We present bi-directional transmission of WiMAXcompliant signaling over an 80-km PON, using a single optical wavelength. Colorless, bi-directional transmission of 256-QAM modulation on a 2.4-GHz RF carrier was achieved at 100- Mb/s (downlink) and 64-Mb/s (uplink)....

  5. Demonstration of DFT-spread 256QAM-OFDM signal transmission with cost-effective directly modulated laser.

    Science.gov (United States)

    Li, Fan; Yu, Jianjun; Fang, Yuan; Dong, Ze; Li, Xinying; Chen, Lin

    2014-04-07

    We experimentally demonstrated a 256-ary quadrature amplitude modulation (256QAM) direct-detection optical orthogonal frequency division multiplexing (DDO-OFDM) transmission system utilizing a cost-effective directly modulated laser (DML). Intra-symbol frequency-domain averaging (ISFA) is applied to suppress in-band noise while the channel response estimation and Discrete Fourier Transform-spread (DFT-spread) is used to reduce the peak-to-average power ratio (PAPR) of the transmitted OFDM signal. The bit-error ratio (BER) of 15-Gbit/s 256QAM-OFDM signal has been measured after 20-km SSMF transmission that is less than 7% forward-error-correction (FEC) threshold of 3.8 × 10(-3) as the launch power into fiber is set at 6dBm. For 11.85-Gbit/s 256QAM-OFDM signal, with the aid of ISFA-based channel estimation and PAPR reduction enabled by DFT-spread, the BER after 20-km SSMF transmission can be improved from 6.4 × 10(-3) to 6.8 × 10(-4) when the received optical power is -6dBm.

  6. 37 CFR 1.324 - Correction of inventorship in patent, pursuant to 35 U.S.C. 256.

    Science.gov (United States)

    2010-07-01

    ... to 35 U.S.C. 256. (a) Whenever through error a person is named in an issued patent as the inventor, or through error an inventor is not named in an issued patent and such error arose without any..., issue a certificate naming only the actual inventor or inventors. A petition to correct inventorship...

  7. The Clinical Hearing Results of 256 Patients with Cleft Palate%256例腭裂患者临床听力学研究

    Institute of Scientific and Technical Information of China (English)

    姚晓琳; 丁瑞英; 王鸿南; 吴玮; 王佩林; 周丽斌; 屈昌北; 马莲; 韩浩伦; 李保卫

    2015-01-01

    目的:通过对腭裂患者行畸变产物耳声发射(Distortion Product Oto-acoustic Emission, DPOAE)、声导抗测试(Acoustic Immittance Measurement,AIM)、听性脑干反应(Auditory Brainstem Response, ABR)研究,探讨这类患者临床听力学特点,以及性别、年龄、手术等因素对患者听力的影响。方法回顾分析256例腭裂患者(术前243例、术后13例)临床听力学数据。将术前2岁内患者174例按性别分为男、女组,所有术前者243例按年龄分为≤2岁组(A组)、>2岁≤6岁组(B组)、>6岁组(C组),术后≥5年者13例编为D组。DPOAE检查选择1818、2730、3616、5434Hz 4个频点有≥3个频点通过即为该耳通过。AIM以A型图为正常,其它类型均为异常。ABR阈值检查以能重复引出V波的最小刺激强度为ABR阈值,ABR阈值>35 dB nHL即为该耳异常。结果腭裂患者不同性别间DPOAE、AIM、ABR阈值无明显差异(P>0.05),A组DPOAE、AIM、ABR阈值较C组差异显著(P0.05),B、C组DPOAE差异显著(P0.05)。C、D组年龄相仿,AIM、ABR检查示差异显著(P2 y≤6 y);and group C (>6 y);to evaluate the effects of surgery, we compared group C to 13cases who had received cleft-closure opera⁃tion (group D), because the ages of these two groups were similar. For DPOAE, at least the pass of≥3 frequencies at 1818;2730;3616;5434Hz was defined as pass. For AIM, type A was considered to be normal. Part of these cases were also tested by ABR, and the threshold of waveⅴ≥35 dB nHL was received to be abnormal.Results 174 Patients (≤2 y, group A)showed no differences in DPOAE, AIM and ABR between sexes (p>0.05). Between group A and group C, DPOAE, AIM and ABR showed significant difference (p0.05). Between group C and group D, whose ages were similar, only AIM and ABR showed significant difference(p<0.05). In group A,B and C together, the pass rate of DPOAE was higher than the normal rate of ABR (p<0

  8. Clinical characteristics analysis of 256 cases with acute myocardial infarction%256例急性心肌梗死临床特点分析

    Institute of Scientific and Technical Information of China (English)

    胡华龙; 张卫

    2012-01-01

    目的:了解急性心肌梗死(AMI)的非典型临床表现,以期提高早期诊断,减少漏、误诊率及降低死亡率.方法:对256例AMI患者进行回顾性总结分析.结果:非典型AMI患者共72例(28.1%);与典型AMI患者相比,非典型患者年龄高(69.8岁:58.5岁,P<0.01),女性比例高(43.1%:30.4%,P<0.01),伴发糖尿病(33.3%:23.9%,P<0.01)和心力衰竭(20.8%:13.6%,P<0.01)比例高,住院期间死亡率高(33.3%:5.2%,P<0.01),平均就诊时间显著延迟(24.5 h:9.8h,P<0.01),入院时确诊率显著降低(20.6%:53.4%,P<0.01).结论:AMI的非典型临床表现相当普遍,导致较高的漏、误诊率,且住院期间病死率显著增加,早期识别能有效提高确诊率,对改善预后有极其重要的意义.%Objective:To explore the atypical clinical manifestations of acute myocardial infarction (AMI), for improving the early diagnosis and reducing the false negative, false positive and fatality rate. Method:Two hundred and fifty-six patients with AMI were chosen to go through the retrospective summary and analysis. Result:There were 72 patients with atypical AMI, and the prevalence rate was 28. 1%. Compared with the typical patients, the atypical patients were characterized with old age (69. 8 vs 58. 5, P<0. 01), higher percentage of women patients (43.1% vs30.4%, P<0.01), combined higher percentage of diabetes history (33. 3% vs23.9%, P<0.01) and cardiac failure history (20.8% vs 13.6%, P<0.01) and higher in-hospital mortality (33.3% vs 5.2%, P< 0. 01). The average treatment time of the atypical patients was significantly delayed (24. 5 h vs 9. 8 h, P<0. 01) and the correct diagnose rate on admission was significantly decreased (20. 6% vs 53. 4%, P<0. 01). Conclusion: The atypical clinical manifestation of AMI is fairly common and results in higher false negative and positive rates. Moreover, the in-hospital fatality rate of patients with atypical AMI significantly increases. Therefore, early

  9. 256层螺旋CT在诊断椎体骨折中的应用价值%The Application Value of 256 Slice Spiral CT in the Diagnosis of Vertebral Fracture

    Institute of Scientific and Technical Information of China (English)

    田春阁

    2015-01-01

    目的:探讨256层螺旋CT在椎体疾病诊断中的临床应用价值。方法对临床怀疑或X线平片诊断椎体外伤及肿瘤所致病理性椎体骨骨折患者进行256层螺旋CT扫描检查,所得图像进行三维及多平面重建技术分析,结果与X线平片比较。结果85例中总椎体骨折数为121个,其中颈椎椎体骨折12个,胸椎椎体骨折56个,腰椎椎体骨折59个,骶尾椎椎体骨折19个。通过对照比较与统计分析。结论是256层螺旋CT对椎体骨折的检出率、诊断符合率明显高于X线平片,是椎体外伤及病理性椎体骨折中疑难鉴别诊断的首选检查方法。%Vertebral fractures often occur in the trauma, the preferred check method for the common X-ray photography, because it has the advantages of fast, and cheap. But vertebral physiological form belongs to irregular complex bone and soft tissue, often increases the missed diagnosis of vertebral fractures. 256 layer of the application of spiral CT, with its extreme-ly fast scanning speed and advantages of post-processing function, improve the diagnosis accuracy of vertebral fractures. This paper summarizes the 85 exception injury and pathological vertebral fracture patients 256 layer spiral CT examination and contrast analyzing X-ray photography, is to investigate 256 layer value of spiral CT in the diagnosis of vertebral frac-tures.

  10. The Walker 256 Breast Cancer Cell- Induced Bone Pain Model in Rats

    Directory of Open Access Journals (Sweden)

    Priyank Ashok Shenoy

    2016-08-01

    Full Text Available The majority of patients with terminal breast cancer show signs of bone metastasis, the most common cause of pain in cancer. Clinically available drug treatment options for the relief of cancer-associated bone pain are limited due to either inadequate pain relief and/or dose-limiting side-effects. One of the major hurdles in understanding the mechanism by which breast cancer causes pain after metastasis to the bones is the lack of suitable preclinical models. Until the late twentieth century, all animal models of cancer induced bone pain involved systemic injection of cancer cells into animals, which caused severe deterioration of animal health due to widespread metastasis. In this mini-review we have discussed details of a recently developed and highly efficient preclinical model of breast cancer induced bone pain: Walker 256 cancer cell- induced bone pain in rats. The model involves direct localized injection of cancer cells into a single tibia in rats, which avoids widespread metastasis of cancer cells and hence animals maintain good health throughout the experimental period. This model closely mimics the human pathophysiology of breast cancer induced bone pain and has great potential to aid in the process of drug discovery for treating this intractable pain condition.

  11. Discovery of Hydrogen Fluoride in the Cloverleaf Quasar at z = 2.56

    CERN Document Server

    Monje, R R; Peng, R; Lis, D C; Neufeld, D A; Emprechtinger, M; 10.1088/2041-8205/742/2/L21

    2012-01-01

    We report the first detection of hydrogen fluoride (HF) toward a high redshift quasar. Using the Caltech Submillimeter Observatory (CSO) we detect the HF J = 1 - 0 transition in absorption toward the Cloverleaf, a broad absorption line (BAL) quasi-stellar object (QSO) at z=2.56. The detection is statistically significant at the ~ 6 sigma level. We estimate a lower limit of 4 \\times 1014 cm-2 for the HF column density and using a previous estimate of the hydrogen column density, we obtain a lower limit of 1.7 \\times 10-9 for the HF abundance. This value suggests that, assuming a Galactic N(HF)/NH ratio, HF accounts for at least ~10% of the fluorine in the gas phase along the line of sight to the Cloverleaf quasar. This observation corroborates the prediction that HF should be a good probe of the molecular gas at high redshift. Measurements of the HF abundance as a function of redshift are urgently needed to better constrain the fluorine nucleosynthesis mechanism(s).

  12. DISCOVERY OF HYDROGEN FLUORIDE IN THE CLOVERLEAF QUASAR AT z = 2.56

    Energy Technology Data Exchange (ETDEWEB)

    Monje, R. R.; Phillips, T. G.; Lis, D. C.; Emprechtinger, M. [California Institute of Technology, 1200 E. California Blvd., Pasadena, CA 91125-4700 (United States); Peng, R. [Caltech Submillimeter Observatory, 111 Nowelo Street, Hilo, HI 96720 (United States); Neufeld, D. A., E-mail: raquel@caltech.edu [Department of Physics and Astronomy, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 (United States)

    2011-12-15

    We report the first detection of hydrogen fluoride (HF) toward a high-redshift quasar. Using the Caltech Submillimeter Observatory, we detect the HF J = 1-0 transition in absorption toward the Cloverleaf, a broad absorption line quasi-stellar object at z = 2.56. The detection is statistically significant at the {approx}6{sigma} level. We estimate a lower limit of 4 Multiplication-Sign 10{sup 14} cm{sup -2} for the HF column density and using a previous estimate of the hydrogen column density, we obtain a lower limit of 1.7 Multiplication-Sign 10{sup -9} for the HF abundance. This value suggests that, assuming a Galactic N(HF)/N{sub H} ratio, HF accounts for at least {approx}10% of the fluorine in the gas phase along the line of sight to the Cloverleaf quasar. This observation corroborates the prediction that HF should be a good probe of the molecular gas at high redshift. Measurements of the HF abundance as a function of redshift are urgently needed to better constrain the fluorine nucleosynthesis mechanism(s).

  13. Spatial mapping and statistical reproducibility of an array of 256 one-dimensional quantum wires

    Energy Technology Data Exchange (ETDEWEB)

    Al-Taie, H., E-mail: ha322@cam.ac.uk; Kelly, M. J. [Centre for Advanced Photonics and Electronics, Electrical Engineering Division, Department of Engineering, 9 J. J. Thomson Avenue, University of Cambridge, Cambridge CB3 0FA (United Kingdom); Cavendish Laboratory, Department of Physics, University of Cambridge, J. J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Smith, L. W.; Lesage, A. A. J.; Griffiths, J. P.; Beere, H. E.; Jones, G. A. C.; Ritchie, D. A.; Smith, C. G. [Cavendish Laboratory, Department of Physics, University of Cambridge, J. J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom); See, P. [National Physical Laboratory, Hampton Road, Teddington, Middlesex TW11 0LW (United Kingdom)

    2015-08-21

    We utilize a multiplexing architecture to measure the conductance properties of an array of 256 split gates. We investigate the reproducibility of the pinch off and one-dimensional definition voltage as a function of spatial location on two different cooldowns, and after illuminating the device. The reproducibility of both these properties on the two cooldowns is high, the result of the density of the two-dimensional electron gas returning to a similar state after thermal cycling. The spatial variation of the pinch-off voltage reduces after illumination; however, the variation of the one-dimensional definition voltage increases due to an anomalous feature in the center of the array. A technique which quantifies the homogeneity of split-gate properties across the array is developed which captures the experimentally observed trends. In addition, the one-dimensional definition voltage is used to probe the density of the wafer at each split gate in the array on a micron scale using a capacitive model.

  14. The Walker 256 Breast Cancer Cell- Induced Bone Pain Model in Rats.

    Science.gov (United States)

    Shenoy, Priyank A; Kuo, Andy; Vetter, Irina; Smith, Maree T

    2016-01-01

    The majority of patients with terminal breast cancer show signs of bone metastasis, the most common cause of pain in cancer. Clinically available drug treatment options for the relief of cancer-associated bone pain are limited due to either inadequate pain relief and/or dose-limiting side-effects. One of the major hurdles in understanding the mechanism by which breast cancer causes pain after metastasis to the bones is the lack of suitable preclinical models. Until the late twentieth century, all animal models of cancer induced bone pain involved systemic injection of cancer cells into animals, which caused severe deterioration of animal health due to widespread metastasis. In this mini-review we have discussed details of a recently developed and highly efficient preclinical model of breast cancer induced bone pain: Walker 256 cancer cell- induced bone pain in rats. The model involves direct localized injection of cancer cells into a single tibia in rats, which avoids widespread metastasis of cancer cells and hence animals maintain good health throughout the experimental period. This model closely mimics the human pathophysiology of breast cancer induced bone pain and has great potential to aid in the process of drug discovery for treating this intractable pain condition.

  15. [Leptospirosis-clinico-biological and therapeutical aspects-study of 256 cases].

    Science.gov (United States)

    Luca, Mihaela Cătălina; Dorobăţ, Carmen; Corcaci, Carmen; Scurtu, Roxana; Luca, V; Mihalache, Doina

    2002-01-01

    Leptospirosis is a zooantroponosis manifested as an infectious disease with a severe evolution, with liver and renal failure and hemorrhagic manifestation. The aim of this study was to present the clinico-biological investigation and the therapeutical aspects of 256 cases of leptospirosis admitted in the Infectious Diseases Hospital Iasi during 4 years (1998-2001). The diagnosis was based on the study of clinico-biological and therapeutical parameters (risk factors, fever, mialgia, headache, algic, eruptive, meningeal, hepatorenal, hemorrhagic syndromes with the serological evidence of the serotypes of leptospirosis); most of the cases were registered in 1998 (23% cases), in adults (31.2%) and male (75.22%). All the patients were serologic confirmed with leptospirosis (RAL and RFC), and L. icterohaemorhagiae was isolated most frequently. The standard anti-leptospirosis treatment was administered with favorable evolution; 6 deaths were registered from the severe forms of the disease. The leptospirosis is an emergent disease with the possibility of severe evolution in some forms, with liver and renal failure.

  16. A reconfigurable on-line learning spiking neuromorphic processor comprising 256 neurons and 128K synapses.

    Science.gov (United States)

    Qiao, Ning; Mostafa, Hesham; Corradi, Federico; Osswald, Marc; Stefanini, Fabio; Sumislawska, Dora; Indiveri, Giacomo

    2015-01-01

    Implementing compact, low-power artificial neural processing systems with real-time on-line learning abilities is still an open challenge. In this paper we present a full-custom mixed-signal VLSI device with neuromorphic learning circuits that emulate the biophysics of real spiking neurons and dynamic synapses for exploring the properties of computational neuroscience models and for building brain-inspired computing systems. The proposed architecture allows the on-chip configuration of a wide range of network connectivities, including recurrent and deep networks, with short-term and long-term plasticity. The device comprises 128 K analog synapse and 256 neuron circuits with biologically plausible dynamics and bi-stable spike-based plasticity mechanisms that endow it with on-line learning abilities. In addition to the analog circuits, the device comprises also asynchronous digital logic circuits for setting different synapse and neuron properties as well as different network configurations. This prototype device, fabricated using a 180 nm 1P6M CMOS process, occupies an area of 51.4 mm(2), and consumes approximately 4 mW for typical experiments, for example involving attractor networks. Here we describe the details of the overall architecture and of the individual circuits and present experimental results that showcase its potential. By supporting a wide range of cortical-like computational modules comprising plasticity mechanisms, this device will enable the realization of intelligent autonomous systems with on-line learning capabilities.

  17. Spatial mapping and statistical reproducibility of an array of 256 one-dimensional quantum wires

    Science.gov (United States)

    Al-Taie, H.; Smith, L. W.; Lesage, A. A. J.; See, P.; Griffiths, J. P.; Beere, H. E.; Jones, G. A. C.; Ritchie, D. A.; Kelly, M. J.; Smith, C. G.

    2015-08-01

    We utilize a multiplexing architecture to measure the conductance properties of an array of 256 split gates. We investigate the reproducibility of the pinch off and one-dimensional definition voltage as a function of spatial location on two different cooldowns, and after illuminating the device. The reproducibility of both these properties on the two cooldowns is high, the result of the density of the two-dimensional electron gas returning to a similar state after thermal cycling. The spatial variation of the pinch-off voltage reduces after illumination; however, the variation of the one-dimensional definition voltage increases due to an anomalous feature in the center of the array. A technique which quantifies the homogeneity of split-gate properties across the array is developed which captures the experimentally observed trends. In addition, the one-dimensional definition voltage is used to probe the density of the wafer at each split gate in the array on a micron scale using a capacitive model.

  18. Health-related quality of life of 256 recipients after liver transplantation

    Institute of Scientific and Technical Information of China (English)

    Pei-Xian Chen; Lu-Nan Yan; Wen-Tao Wang

    2012-01-01

    AIM:To investigate health-related quality of life (HRQoL)and psychological outcomes in 256 adults who had undergone liver transplantation (LT).METHODS:A stratified random sampling method was used in this follow-up multicenter study to select a representative sample of recipients undergoing either living donor liver transplantation (LDLT) or deceased donor liver transplantation (DDLT).HRQoL was measured by using the Chinese version of Medical Outcome Study Short Form-36 (SF-36),and psychological outcomes by using the beck anxiety inventory (BAI)and the self-rating depression scale (SDS).Clinical and demographic data were collected from the records of the Chinese Liver Transplant Registry and via questionnaires.RESULTS:A total of 256 patients were sampled,including 66 (25.8%) receiving LDLT and 190 (74.2%)undergoing DDLT; 15 (5.9%) recipients had anxiety and four (1.6%) developed severe depression after the operation.Compared with LDLT recipients,DDLT patients had higher scores in general health (60.33± 16.97 vs 66.86 ± 18.42,P =0.012),role-physical (63.64 ± 42.55 vs 74.47 ± 36.46,P =0.048),roleemotional (61.11 ± 44.37 vs 78.95 ± 34.31,P =0.001),social functioning (78.60 ± 22.76 vs 88.16 ± 21.85,P =0.003),vitality (70.30 ± 15.76 vs 75.95 ± 16.40,P =0.016),mental health (65.88 ± 12.94 vs 71.85 ±15.45,P =0.005),physical component summary scale (PCS,60.07 ± 7.36 vs 62.58 ± 6.88,P =0.013) and mental component summary scale (MCS,52.65 ± 7.66vs 55.95 ± 10.14,P =0.016).Recipients > 45 years old at the time of transplant scored higher in vitality (77.33 ± 15.64 vs 72.52 ± 16.66,P =0.020),mental health (73.64 ± 15.06 vs 68.00 ± 14.65,P =0.003)and MCS (56.61 ± 10.00 vs 54.05 ± 9.30,P =0.037)than those aged ≤ 45 years.MCS was poorer in recipients with than in those without complications (52.92± 12.21 vs 56.06 ± 8.16,P =0.017).Regarding MCS (55.10 ± 9.66 vs 50.0 ± 10.0,P < 0.05) and PCS (61.93± 7.08 vs 50.0 ± 10.0,P < 0.05),recipients

  19. Coronary lesion complexity assessed by SYNTAX score in 256-slice dual-source MDCT angiography

    Science.gov (United States)

    Yüceler, Zeyneb; Kantarcı, Mecit; Tanboğa, İbrahim Halil; Sade, Recep; Kızrak, Yeşim; Pirimoğlu, Berhan; Bayraktutan, Ümmügülsüm; Oğul, Hayri; Aksakal, Enbiya

    2016-01-01

    PURPOSE The SYNTAX Score (SS) has an important role in grading the complexity of coronary artery disease (CAD) in patients undergoing revascularization. Noninvasive determination of SS prior to invasive coronary angiography (ICA) might optimize patient management. We aimed to evaluate the agreement between ICA and multidetector computed tomography (MDCT) while testing the diagnostic effectiveness of SS-MDCT. METHODS Our study included 108 consecutive patients who underwent both MDCT angiography with a 256-slice dual-source MDCT system and ICA within 14±3 days. SS was calculated for both ICA and MDCT coronary angiography. Spearman’s rank correlation coefficient was used to evaluate the association of SS-MDCT with SS-ICA, and Bland-Altman analysis was performed. RESULTS The degree of agreement between SS-ICA and SS-MDCT was moderate. The mean SS-MDCT was 14.5, whereas the mean SS-ICA was 15.9. After dividing SS into three groups (high [≥33], intermediate [23–32], and low [≤22] subgroups), agreement analysis was repeated. There was a significant correlation between SS-MDCT and SS-ICA in the low SS group (r=0.63, P = 0.043) but no significant correlation in the high SS group (r=0.036, P = 0.677). The inter-test agreement analysis showed at least moderate agreement, whereas thrombotic lesions and the type of bifurcation lesion showed fair agreement. CONCLUSION The calculation of SS-MDCT by adapting SS-ICA parameters achieved nearly the same degree of precision as SS-ICA and was better than SS-ICA, especially in the low SS group. PMID:27328718

  20. 儿童胃肠道轮状病毒感染256例调查分析

    Institute of Scientific and Technical Information of China (English)

    张静

    2011-01-01

    <正>轮状病毒(rotavirus RV)是小儿常见的胃肠疾病之一,尤其在秋冬季短期内发生大量流行,直接影响小儿健康。现将库尔勒垦区2009年至2010年来我院诊治的256例小儿轮状病毒肠炎的临床流行病

  1. Fission of 255,256Es, 255-257Fm, and 258Md at moderate excitation energies

    NARCIS (Netherlands)

    Britt, H.C.; Hoffman, D.C.; Plicht, J. van der; Wilhelmy, J.; Cheifetz, E.; Dupzyk, R.J.; Lougheed, R.W.

    1984-01-01

    The fission of 255,256Es, 255-257Fm, and 258Md has been studied in the excitation energy range from threshold to 25 MeV. A target of 254Es was used in the direct reaction studies; (d,pf), (t,pf), (3He,df), (3He,pf), and in the compound induced fission reactions formed with p, d, t, and α particle pr

  2. Evaluation of the Anomalous Posterior Circulation with 256-Slice Spiral CT and Its Clinical Application%256层CT诊断大脑后循环血管变异及临床应用

    Institute of Scientific and Technical Information of China (English)

    闫燃; 任安; 黄振国; 尚燕宁; 胡莹莹

    2012-01-01

    Objective To assess the value of 256-slice spiral computed tomography in the diagnosis of anomalous posterior circulation. Methods The data of 341 patients(of head and neck) were retrospectively analyzed,maximum intensity projection ( M1P) ,curved plannar reformation( CPR) and volume rendering( VR) were used to assess the vessels. Results 105 patients with anomalous posterior circulation were identified, including anomalous of the vertebral artery ( VA, n = 80) , anomalous of the brobasilar artery ( n = 12 ), fetal origin of the posterior cerebral artery FTP ( n = 42) , including one anomalous 54 cases (51.43% ) ,two or more anomalous 51 cases(48. 57% ). Conclusion 256-slice CTA was a rapid,noninvasive and accurate method for the diagnosis of anomalous posterior circulation, and other associated vascular anomalies.%目的 研究256层CT对大脑后循环变异的诊断价值,并探讨其临床意义.方法 回顾性分析341例经头颈256层CT行CTA检查的患者的影像资料学表现,将原始图像采用容积成像(VR)、最大密度投影(MIP)、曲面重建( CPR)等方法重建.结果 诊断为大脑后循环血管变异105例(30.49%),椎动脉变异80例(23.46%),基底动脉窗式变异12例(3.52%),大脑后动脉变异42例(12.32%),其中单一变异54例(51.43%),合并两种及以上变异51例(48.57%).结论 256层CT血管造影不仅能全面、快速、无创、准确地诊断大脑后循环血管变异,同时还能显示伴发的其他病变,可以作为大脑后循环变异的常规检查方法之一.

  3. Caliste 256: A CdTe imaging spectrometer for space science with a 580 {mu}m pixel pitch

    Energy Technology Data Exchange (ETDEWEB)

    Limousin, O., E-mail: olimousin@cea.fr [CEA/Saclay, DSM/Irfu/Service d' Astrophysique, F-91191 Gif-sur-Yvette (France); Lugiez, F.; Gevin, O. [CEA/Saclay, DSM/Irfu/Service d' Electronique Detecteurs et Informatique, F-91191 Gif-sur-Yvette (France); Meuris, A.; Blondel, C. [CEA/Saclay, DSM/Irfu/Service d' Astrophysique, F-91191 Gif-sur-Yvette (France); Delagnes, E. [CEA/Saclay, DSM/Irfu/Service d' Electronique Detecteurs et Informatique, F-91191 Gif-sur-Yvette (France); Donati, M.; Le Mer, I.; Martignac, J.; Pinsard, F. [CEA/Saclay, DSM/Irfu/Service d' Astrophysique, F-91191 Gif-sur-Yvette (France); Vassal, M.C.; Bocage, R.; Soufflet, F. [3D Plus, 641 rue Helene Boucher, F-78532 Buc (France)

    2011-08-11

    Caliste project aims at hybridizing 1 cm{sup 2} CdTe or CdZnTe pixel detectors with low-noise full custom front-end electronics, in a single component standing in a 1x1x2 cm{sup 3} volume. Caliste device is 4-side buttable and can be used as elementary detection unit of a large mosaic to form a hard X-ray focal plane of any size and shape. Caliste is especially designed to match astronomical space mission requirements and its design takes into account environmental constraints, radiation environment in particular. This new imaging spectrometer for hard X-rays detection offers high spectral and spatial resolution together with accurate time-tagging capability and low dead time. Caliste concept relies on a 3D hybridization technology that consists in stacking full custom ASICs perpendicular to the detection surface into a single component. This technique simultaneously permits to realize a buttable imager and to enhance performance and uniformity response. Our last prototype is called Caliste 256 and integrates 16x16 pixels array, 580 {mu}m pitch and 256 corresponding independent spectroscopy channels. This paper presents Caliste 256 design and properties. We emphasize spectral performance and demonstrate spectral resolution capabilities better than 1 keV FWHM at 60 keV.

  4. Genome Anatomy of Pyrenochaeta unguis-hominis UM 256, a Multidrug Resistant Strain Isolated from Skin Scraping.

    Science.gov (United States)

    Toh, Yue Fen; Yew, Su Mei; Chan, Chai Ling; Na, Shiang Ling; Lee, Kok Wei; Hoh, Chee-Choong; Yee, Wai-Yan; Ng, Kee Peng; Kuan, Chee Sian

    2016-01-01

    Pyrenochaeta unguis-hominis is a rare human pathogen that causes infection in human skin and nail. P. unguis-hominis has received little attention, and thus, the basic biology and pathogenicity of this fungus is not fully understood. In this study, we performed in-depth analysis of the P. unguis-hominis UM 256 genome that was isolated from the skin scraping of a dermatitis patient. The isolate was identified to species level using a comprehensive multilocus phylogenetic analysis of the genus Pyrenochaeta. The assembled UM 256 genome has a size of 35.5 Mb and encodes 12,545 putative genes, and 0.34% of the assembled genome is predicted transposable elements. Its genomic features propose that the fungus is a heterothallic fungus that encodes a wide array of plant cell wall degrading enzymes, peptidases, and secondary metabolite biosynthetic enzymes. Antifungal drug resistance genes including MDR, CDR, and ERG11/CYP51 were identified in P. unguis-hominis UM 256, which may confer resistance to this fungus. The genome analysis of P. unguis-hominis provides an insight into molecular and genetic basis of the fungal lifestyles, understanding the unrevealed biology of antifungal resistance in this fungus.

  5. 基于SHA256散列算法的比特币挖矿优化研究

    Institute of Scientific and Technical Information of China (English)

    陈雷; 王文国

    2015-01-01

    自2009年成立以来,比特币已经拥有了大量的用户,这种虚拟货币的受欢迎程度与日俱增.多年来,军备竞赛般的采矿硬件导致需要更多的采矿股,因此散列率仍然活跃在比特币采矿舞台上,而散列率对所使用的挖掘装置的能耗直接关系到Bitcoin开采的利润率的高低.比特币挖掘是从根本上计算关于双输入某一流的SHA256多次散列,大量的研究也都在对SHA256散列标准实现硬件的优化.但并没有尝试优化特定比特币的SHA256算法.本文介绍Bitcoin的领域,Bitcoin的挖掘以及一点改进的建议,重点是对比特币挖掘方法从根本上进行优化.

  6. Genome Anatomy of Pyrenochaeta unguis-hominis UM 256, a Multidrug Resistant Strain Isolated from Skin Scraping

    Science.gov (United States)

    Toh, Yue Fen; Yew, Su Mei; Chan, Chai Ling; Na, Shiang Ling; Lee, Kok Wei; Hoh, Chee-Choong; Yee, Wai-Yan; Ng, Kee Peng

    2016-01-01

    Pyrenochaeta unguis-hominis is a rare human pathogen that causes infection in human skin and nail. P. unguis-hominis has received little attention, and thus, the basic biology and pathogenicity of this fungus is not fully understood. In this study, we performed in-depth analysis of the P. unguis-hominis UM 256 genome that was isolated from the skin scraping of a dermatitis patient. The isolate was identified to species level using a comprehensive multilocus phylogenetic analysis of the genus Pyrenochaeta. The assembled UM 256 genome has a size of 35.5 Mb and encodes 12,545 putative genes, and 0.34% of the assembled genome is predicted transposable elements. Its genomic features propose that the fungus is a heterothallic fungus that encodes a wide array of plant cell wall degrading enzymes, peptidases, and secondary metabolite biosynthetic enzymes. Antifungal drug resistance genes including MDR, CDR, and ERG11/CYP51 were identified in P. unguis-hominis UM 256, which may confer resistance to this fungus. The genome analysis of P. unguis-hominis provides an insight into molecular and genetic basis of the fungal lifestyles, understanding the unrevealed biology of antifungal resistance in this fungus. PMID:27626635

  7. A customizable commercial miniaturized 320×256 indium gallium arsenide shortwave infrared camera

    Science.gov (United States)

    Huang, Shih-Che; O'Grady, Matthew; Groppe, Joseph V.; Ettenberg, Martin H.; Brubaker, Robert M.

    2004-10-01

    The design and performance of a commercial short-wave-infrared (SWIR) InGaAs microcamera engine is presented. The 0.9-to-1.7 micron SWIR imaging system consists of a room-temperature-TEC-stabilized, 320x256 (25 μm pitch) InGaAs focal plane array (FPA) and a high-performance, highly customizable image-processing set of electronics. The detectivity, D*, of the system is greater than 1013 cm-√Hz/W at 1.55 μm, and this sensitivity may be adjusted in real-time over 100 dB. It features snapshot-mode integration with a minimum exposure time of 130 μs. The digital video processor provides real time pixel-to-pixel, 2-point dark-current subtraction and non-uniformity compensation along with defective-pixel substitution. Other features include automatic gain control (AGC), gamma correction, 7 preset configurations, adjustable exposure time, external triggering, and windowing. The windowing feature is highly flexible; the region of interest (ROI) may be placed anywhere on the imager and can be varied at will. Windowing allows for high-speed readout enabling such applications as target acquisition and tracking; for example, a 32x32 ROI window may be read out at over 3500 frames per second (fps). Output video is provided as EIA170-compatible analog, or as 12-bit CameraLink-compatible digital. All the above features are accomplished in a small volume < 28 cm3, weight < 70 g, and with low power consumption < 1.3 W at room temperature using this new microcamera engine. Video processing is based on a field-programmable gate array (FPGA) platform with a soft-embedded processor that allows for ease of integration/addition of customer-specific algorithms, processes, or design requirements. The camera was developed with the high-performance, space-restricted, power-conscious application in mind, such as robotic or UAV deployment.

  8. Simultaneous transmission of 256-QAM WIMAX at 5.7GHz and optically generated impulse radio UWB over fiber for indoor wireless multi-services

    DEFF Research Database (Denmark)

    Yu, Xianbin; Yin, Xiaoli; Gibbon, Timothy Braidwood;

    2010-01-01

    Fiber transmission of simultaneous optically generated FCC compliant 625Mbps impulse radio UWB and 80Mbps 256-QAM IEEE 802.16 WIMAX signals is experimentally demonstrated by using a single directly modulated light source.......Fiber transmission of simultaneous optically generated FCC compliant 625Mbps impulse radio UWB and 80Mbps 256-QAM IEEE 802.16 WIMAX signals is experimentally demonstrated by using a single directly modulated light source....

  9. Synthesis, radiolabeling, and baboon SPECT imaging of 2β-carbomethoxy-3β-(3′-[123I]iodophenyl)tropane ([123I]YP256) as a serotonin transporter radiotracer.([123I]YP256) a potential serotonin transporter radiotracer)

    Science.gov (United States)

    Bois, Frederic; Baldwin, Ronald M.; Amici, Louis; Al-Tikriti, Mohammed S.; Kula, Nora; Baldessarini, Ross; Innis, Robert B.; Staley, Julie K.; Tamagnan., Gilles D.

    2008-01-01

    To develop a potential SPECT probe to evaluate the integrity of the serotoninergic system (5-HTT) whose dysfunction is linked to several disease conditions such as Parkinson’s, Alzheimer’s diseases and depression, we report the synthesis, radiolabeling and in vivo baboon imaging of 2β-carbomethoxy-3β-(3′-[123I]iodophenyl) tropane (YP256, 6). The radiolabeling was performed by iododestannylation using sodium [123I]iodide and peracetic acid. Although the ligand displayed high selectivity for 5-HTT over dopamine transporter (DAT) in vitro, SPECT imaging in baboons did not reveal selective 5-HTT accumulation in brain in vivo. PMID:18158943

  10. 头颈部血管变异的256层螺旋CT诊断及临床探讨%Diagnosis and clinical study of 256 -slice spiral CT in vascular variation of head and neck

    Institute of Scientific and Technical Information of China (English)

    王健; 杜晓兢

    2016-01-01

    Objective To investigate the diagnostic value of 256 -slice spiral CT angiography (CTA)in vascular variation of head and neck,and discuss its clinical significance.Methods Retrospectively analyzed 140 patients'CTA image with vascular variation of head and neck,which were analysed through a variety of reforma-tion method.Results In 140 patients with vascular variation of head and neck,there were 39 patients with vertebral artery variation(27.86%);27 patients with vascular duplication or absence(19.29%);71 patients with posterior cer-ebral artery variation (50.71%);7 patients with other kind of vascular variation (5.00%).Conclusion 256 -slice spiral CTA can clearly show normal anatomical structure and anatomical variation of head and neck arteries,which is helpful to guide the clinical doctor to make a reasonable surgical approach and treatment plan,improve the safety of surgical treatment.%目的:研究256层螺旋 CT 血管成像(CTA)对头颈部各种血管变异的诊断价值,并探讨其临床意义。方法回顾分析140例头颈部血管变异的 CTA 成像资料,通过多种重组方法对影像进行重建,并对变异血管进行分析。结果140例头颈部血管变异患者,其中椎动脉变异39例(27.86%);血管重复变异和缺如变异27例(19.29%);大脑后动脉变异71例(50.71%);其他血管变异7例(5.00%)。结论256层螺旋CTA 可很好地显示头颈部血管的正常解剖结构和解剖变异,有助于指导临床医生选择合理的手术路径及治疗方案,提高手术治疗的安全性。

  11. Design of read/write device for AT88RF256 RFID card%AT88RF256 型射频卡读写器的设计

    Institute of Scientific and Technical Information of China (English)

    董新宇; 王占国; 李杏春

    2006-01-01

    介绍采用北京威利姆兴公司AT-RFMOD06系列射频基站模块结合PIC16型单片机开发的适用于125 kHz低频的AT88RF256型射频卡读写器.重点介绍基站模块的硬件连接及如何通过基站完成对射频卡的读写等控制,并给出相应的应用软件.

  12. Respiratory-gated segment reconstruction for radiation treatment planning using 256-slice CT-scanner during free breathing

    Science.gov (United States)

    Mori, Shinichiro; Endo, Masahiro; Kohno, Ryosuke; Minohara, Shinichi; Kohno, Kazutoshi; Asakura, Hiroshi; Fujiwara, Hideaki; Murase, Kenya

    2005-04-01

    The conventional respiratory-gated CT scan technique includes anatomic motion induced artifacts due to the low temporal resolution. They are a significant source of error in radiotherapy treatment planning for the thorax and upper abdomen. Temporal resolution and image quality are important factors to minimize planning target volume margin due to the respiratory motion. To achieve high temporal resolution and high signal-to-noise ratio, we developed a respiratory gated segment reconstruction algorithm and adapted it to Feldkamp-Davis-Kress algorithm (FDK) with a 256-detector row CT. The 256-detector row CT could scan approximately 100 mm in the cranio-caudal direction with 0.5 mm slice thickness in one rotation. Data acquisition for the RS-FDK relies on the assistance of the respiratory sensing system by a cine scan mode (table remains stationary). We evaluated RS-FDK in phantom study with the 256-detector row CT and compared it with full scan (FS-FDK) and HS-FDK results with regard to volume accuracy and image noise, and finally adapted the RS-FDK to an animal study. The RS-FDK gave a more accurate volume than the others and it had the same signal-to-noise ratio as the FS-FDK. In the animal study, the RS-FDK visualized the clearest edges of the liver and pulmonary vessels of all the algorithms. In conclusion, the RS-FDK algorithm has a capability of high temporal resolution and high signal-to-noise ratio. Therefore it will be useful when combined with new radiotherapy techniques including image guided radiation therapy (IGRT) and 4D radiation therapy.

  13. The superiority of 256-slice spiral computed tomography angiography for preoperative evaluation of surrounding arteries in patients with gastric cancer

    Science.gov (United States)

    Wu, Deqing; Zhao, Linyong; Liu, Ying; Wang, Junjiang; Hu, Weixian; Feng, Xingyu; Lv, Zejian; Li, Yong; Yao, Xueqing

    2017-01-01

    Objective To evaluate the utilization of 256-slice spiral computed tomography (CT) angiography in preoperative assessment of perigastric vascular anatomy in patients with gastric cancer. Methods In this study, 80 gastric cancer patients were included. The medical procedure of 256-slice spiral CT angiography was performed on each of these patients consecutively. Thereafter, these patients were subjected to surgical treatment in our hospital. The techniques of volume rendering (VR) and maximum intensity projection (MIP) were used to image reconstruction of arteries around the stomach. Results Both VR and MIP were applied to reconstruct the images of perigastric arteries. The results indicated that VR imaging was inferior to MIP in determining the variant small artery anatomy around the greater curvature and fundus. The respective rates of imaging produced by VR and MIP for left gastroepiploic artery, short gastric artery, and posterior gastric artery, were 32.50% versus 100%, 16.25% versus 87.50%, and 3.75% versus 25.00%, respectively. According to Hiatt’s classification, 75 out of 240 cases were abnormal types, among which we found Type II in 30 cases, Type III in 33 cases, Type IV in three cases, Type V in six cases, and Type VI in only three cases. There was no significant difference for total and every single variation type, between our group and Hiatt’s group (P>0.05). Conclusion The 256-slice spiral CT angiography can be regarded as an effective and accurate diagnostic modality for preoperative assessing anatomical arterial variations in gastric cancer; MIP was superior to VR at identifying variations of some small artery, whereas VR was better than MIP at showing anatomical arterial variations due to its three-dimensional effect.

  14. Power fading mitigation of 40-Gbit/s 256-QAM OFDM carried by colorless laser diode under injection-locking.

    Science.gov (United States)

    Tsai, Cheng-Ting; Chi, Yu-Chieh; Lin, Gong-Ru

    2015-11-02

    The pre-compensation on power fading effect of a colorless laser diode (CLD) carried 40-Gbit/s 256-QAM OFDM transmission during 25-km is demonstrated. By offsetting the DC bias to thrice the threshold (I(th)) and increasing the injection to 0 dBm, the CLD not only enhances its coherence but also suppresses modulation throughput declination and reduces the relative intensity related noise floor to -50 dBm. Modeling the receiving power of the delivered 256-QAM OFDM subcarriers is established, indicating that raising the bias to 3I(th) down-shifts the power fading induced notch to 8.8 GHz. This further degrades the OFDM subcarrier peak power by -2.9 dB after 25-km transmission, and the corresponded signal-to-noise ratio (SNR), error vector magnitude (EVM) and bit-error-rate (BER) are 26.1 dB, 4.9% and 6.5 × 10(-3), respectively. Pre-leveling the OFDM subcarrier as well as the modulation throughput effectively compromises the over-bias enlarged power fading to promote transmission. With a pre-leveled power slope of 1.5 dB/GHz for 256-QAM OFDM data, the modulation throughput declination of the high biased CLD significantly mitigates under BtB transmission, enabling the receiving sensitivity at -7.2 dBm with SNR, EVM and BER of 29.9 dB, 3.1% and 1.5 × 10(-4), respectively. Increasing the pre-leveling slope to 3.2 dB/GHz minimizes the fiber dispersion induced power fading, which improves the receiving SNR, EVM and BER to 27.4 dB, 4.2% and 2.6 × 10(-3), respectively, with receiving sensitivity of -3 dBm and power penalty of 4.2 dB after 25-km SMF transmission.

  15. La jerarquía de vínculos socioafectivos en Ilíada XXIII.1-256

    OpenAIRE

    Difabio de Raimondo, Elbia Haydée

    2001-01-01

    El artículo analiza las relaciones entre Aquiles y sus camaradas en la primera parte del canto XXIII (vv. 1-256), sobre la base de una mirada lingüístico-poética y un enfoque ético-pedagógico. Aquiles tiene dos comportamientos diferentes: como amigo y como caudillo. A Patroclo le dedica sus mejores manifestaciones de ternura y afecto. Como jefe, se dirige primero a sus camaradas más próximos, los mirmidones, y luego, según avanza el canto, a Agamenón, los nobles, las tropas, la comitiva más c...

  16. 256层CT冠状动脉造影中前瞻性心电门控技术的应用价值%Application Value of Prospective ECG-gated 256-slice CT Coronary Angiography

    Institute of Scientific and Technical Information of China (English)

    李佩玲; 李菁菁; 谢秀丽; 徐克

    2012-01-01

    Objective To explore the application value and limitation of prospective ECG-gated 256-slice CT coronary angiography by comparing image quality and patient radiation dose received by prospective ECG-gated scan with those obtained by retrospective ECG-gated scan. Methods A total of 193 cases were collected in this study. 90 cases accepted prospective ECG-gated 256-slice CT coronary angiography (group A) and 103 cases accepted retrospective ECG-gated scan as a contrast group (group B). The CT dose index of volume,length of scan field were recorded immediately after scan and the dose length product and effective radiation dose (ED) were calculated. Post processing methods included volume rendering,curved planar reconstruction and multiplanar reconstruction. Each coronary segment was scored according to the post-processed image quality. Results The mean ED in group A with an average heart rate of 69 bpm was (4.11 ±1.36) mSv and that in group B with an average heart rate of 78 bpm (12.10±5.62) mSv. The evaluable rate in group A was 94.1% and that in group B was 93.6%. There was statistically significant difference in the mean ED (P 0.05) between group A and group B. Conclusion Prospective ECG-gated 256-slice CT coronary angiography could keep satisfactory image quality and reduce radiation dose. It should be used in clinic at the most if the heart rate adaptive.%目的 通过比较256层CT前瞻性与回顾性心电门控冠状动脉造影的图像质量和辐射剂量,探讨前瞻性心电门控在冠状动脉造影中的应用价值和限度.方法 收集接受冠状动脉CT造影检查并采用前瞻性心电门控扫描者90例,采用回顾性心电门控扫描者103例.扫描时记录容积剂量指数及扫描野长度,计算剂量长度乘积和有效辐射剂量.所有患者均采用容积重建、曲面重建及多平面重建等后处理技术,对各冠状动脉节段的图像质量进行评分.结果 前瞻性心电门控扫描组和回顾性心电门控

  17. The Classification of Musa L.Based on mtDNA ccb256 Sequence%芭蕉属植物基于线粒体ccb256序列的分类研究

    Institute of Scientific and Technical Information of China (English)

    邓长娟; 王静毅; 陈友; 冯慧敏; 徐小雄; 武耀廷

    2011-01-01

    The phylogeny and relationship among 42 accessions were investigated by analyzing DNA sequence obtained from mtDNA cytochrome c biogenesis orf256 (ccb256). The phylogenetic tree was constructed following maximum parsimony (MP) method using MEGA4. The results indicated that Australimusa and Callimusa section grouped together; AA and other species from Eumusa clustered with Rhodochlamys section. BB species from Eumusa section were placed a outgroup which revealed its primitive position in evolution of Musa L. In addition, Ice cream (ABB) and M. Balbisiana formed one group which showed that M. Balbisiana may be male parent providing B genotype for Ice cream. Except for Improved lady finger (AAB), other cultivated accessions and M. Acuminata formed a group. It was inferred that M. Acuminata provided A genotype for these accessions as a paternal plant. M. Acumlnata.ssp.banksii, which was considered to be the original parent of cultivars, grouped with almost all the cultivated accessions. It had a close relationship with cultivars. The results also showed that ccb256 sequence had a moderate evolutional rate, which should assist in gaining a better understanding of the evolution of wild and cultivated bananas and of the relationships between diploid and triploid bananas.%利用PCR和PCR产物直接序列分析技术,获得了芭蕉属42份材料ccb256线粒体DNA片段的序列.采用MEGA4软件构建了芭蕉属植物的MP树.结果表明,Australimusa组和Callimusa组聚到一起,真蕉组的AA、其它种和观赏蕉组聚到一起,无法明显区分.真蕉组的BB单独聚到一起,且位于MP的基部,揭示了其在芭蕉属植物进化中占据着最原始的地位.另外,栽培蕉Ice cream(ABB)与M.balbisiana聚到一起,可能是由M.balbisiana为父本提供B型供体杂交而来,而除Improved lady finger(AAB)外,其它的栽培蕉均与M.acuminata的亚(变)种聚到一起,推测由M.acuminata为父本提供A型供体杂交而来.被认为是所有栽培蕉

  18. IS256 abolishes gelatinase activity and biofilm formation in a mutant of the nosocomial pathogen Enterococcus faecalis V583.

    Science.gov (United States)

    Perez, Marta; Calles-Enríquez, Marina; del Rio, Beatriz; Ladero, Victor; Martín, María Cruz; Fernández, María; Alvarez, Miguel A

    2015-07-01

    Enterococcus faecalis is one of the most controversial species of lactic acid bacteria. Some strains are used as probiotics, while others are associated with severe and life-threatening nosocomial infections. Their pathogenicity depends on the acquisition of multidrug resistance and virulence factors. Gelatinase, which is required in the first steps of biofilm formation, is an important virulence determinant involved in E. faecalis pathogenesis, including endocarditis and peritonitis. The gene that codes for gelatinase (gelE) is controlled by the Fsr quorum-sensing system, whose encoding genes (fsrA, fsrB, fsrC, and fsrD) are located immediately upstream of gelE. The integration of a DNA fragment into the fsr locus of a derived mutant of E. faecalis V583 suppressed the gelatinase activity and prevented biofilm formation. Sequence analysis indicated the presence of IS256 integrated into the fsrC gene at nucleotide position 321. Interestingly, IS256 is also associated with biofilm formation in Staphylococcus epidermidis and Staphylococcus aureus. This is the first description of an insertion sequence that prevents biofilm formation in E. faecalis.

  19. Implementation of RSA 2048-bit and AES 256-bit with Digital Signature for Secure Electronic Health Record Application

    Directory of Open Access Journals (Sweden)

    Mohamad Ali Sadikin

    2016-10-01

    Full Text Available This research addresses the implementation of encryption and digital signature technique for electronic health record to prevent cybercrime such as robbery, modification and unauthorised access. In this research, RSA 2048-bit algorithm, AES 256-bit and SHA 256 will be implemented in Java programming language. Secure Electronic Health Record Information (SEHR application design is intended to combine given services, such as confidentiality, integrity, authentication, and nonrepudiation. Cryptography is used to ensure the file records and electronic documents for detailed information on the medical past, present and future forecasts that have been given only to the intended patients. The document will be encrypted using an encryption algorithm based on NIST Standard. In the application, there are two schemes, namely the protection and verification scheme. This research uses black-box testing and whitebox testing to test the software input, output, and code without testing the process and design that occurs in the system.We demonstrated the implementation of cryptography in SEHR. The implementation of encryption and digital signature in this research can prevent archive thievery.

  20. Brain perfusion CT for acute stroke using a 256-slice CT: improvement of diagnostic information by large volume coverage

    Energy Technology Data Exchange (ETDEWEB)

    Dorn, F. [Technical University, Department of Radiology, Klinikum rechts der Isar, Munich (Germany); Institut fuer Radiologie, Klinikum rechts der Isar der Technischen Universitaet Muenchen, Muenchen (Germany); Muenzel, D.; Meier, R.; Rummeny, E.J.; Huber, A. [Technical University, Department of Radiology, Klinikum rechts der Isar, Munich (Germany); Poppert, H. [Technical University, Department of Neurology, Klinikum rechts der Isar, Munich (Germany)

    2011-09-15

    To compare a 256-slice CT with a simulated standard CT for brain CT perfusion (CTP). CTP was obtained in 51 patients using a 256-slice CT (128 detector rows, flying z-focus, 8-cm detector width, 80 kV, 120mAs, 20 measurements, 1 CT image/2.5 s). Signal-to-noise ratios (SNR) were compared in grey and white matter. Perfusion maps were evaluated for cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) in hypoperfused areas and corresponding contralateral regions. Two reconstructed 10-mm slices for simulation of a standard CT (SDCT) were compared with the complete data sets (large-volume CT, LVCT). Adequate image quality was achieved in 50/51 cases. SNR were significantly different in grey and white matter. A perfusion deficit was present in 27 data sets. Differences between the hypoperfusions and the control regions were significant for MTT and CBF, but not for CBV. Three lesions were missed by SDCT but detected by LVCT; 24 lesions were covered incompletely by SDCT, and 6 by LVCT. 21 lesions were detected completely by LVCT, but none by SDCT. CTP imaging of the brain using an increased detector width can detect additional ischaemic lesions and cover most ischaemic lesions completely. (orig.)

  1. Application of indirect 256-slice computed tomography venography (MSCTV) in diagnosing lower extremity deep vein diseases%256层螺旋CT间接法静脉造影在下肢静脉疾病中的价值

    Institute of Scientific and Technical Information of China (English)

    李鹏飞; 龚金山

    2015-01-01

    Objective To evaluate the application value of indirect 256‐slice computed tomography venography (MSCTV) in diagnosing lower extremity deep vein diseases .Methods 30 patients highly suspected deep vein diseases un‐derwent indirect CTV .The original data were put into EBWworkstation and reconstructed with maximum intensity projec‐tion (MIP) ,multiplanar reformation (MPR) ,volume representation (VR) ,and the CT diagnoses were compared with DSA venography .Results Indirect CTV shows reconstruction images clearly in all patients .In the 30 cases ,18 cases dis‐play different parts and different degrees of thrombosis ,20 cases display varicosity of lower extremity ,4 cases display ste‐nosis or occluded of the lower extremity ,1 case displays arteriosclerosis of the lower extremity ,5 cases display collateral circulation .The CTV results conform DSA venography .Conclusion Indirect CTV of lower extremity deep vein diseases has an important value ,which is non‐invasive and highly corresponded to DSA venography .%目的:探讨256层螺旋C T间接静脉造影在下肢静脉疾病的临床应用价值。方法对30例患者进行间接法静脉造影,采集数据导入EBW工作站进行后处理,均进行最大密度投影(M IP )、多平面重组(M PR )、容积再现(V R )重建,得出CT诊断,并与DSA下肢静脉造影(作为金标准)结果对比。结果所有患者靶血管显示良好,30例患者中深静脉血栓形成18例,下肢静脉曲张20例,下肢静脉狭窄4例,下肢静脉硬化1例,侧枝循环5例。MSCTV 诊断结果与DSA造影基本相符。结论256层螺旋CT间接法静脉造影是一种无创性,在下肢静脉疾病中具有重要的临床价值。

  2. Diagnostic Accuracy of 256-Slice CT for Detecting Isolated Superior Mesenteric Artery Lesions%256层CT对孤立性肠系膜上动脉病变的诊断价值

    Institute of Scientific and Technical Information of China (English)

    叶自青; 王珏; 范占明; 刘英峰

    2016-01-01

    目的:探讨孤立性肠系膜上动脉病变(isolated superior mesenteric artery lesions,ISMAL)的256层CT的影像特征。方法回顾性分析12例ISMAL患者的影像及临床资料,以平扫横轴位、增强扫描横轴位、容积再现(VR)、曲面重建(CPR)、最大密度投影(MIP)等重建方法对肠系膜上动脉病变进行分析观察,总结其影像学特征。结果 ISMAL患者平均年龄为(50.1±2.7)岁,男性9例占75%,女性3例占25%,男性发生率高于女性。肠系膜上动脉栓塞(superior mesenteric artery embolism, SMAE)共8例,其中男性5例,女性3例;肠系膜上动脉夹层(superior mesenteric artery dissection, SMAD)共4例,均为男性;管腔局部增宽、腔内充盈缺损是SMAE典型征象;腔内条形低密度影并双腔的显示是SMAD的典型表现。结论256层CT平扫及CTA图像后处理技术可清晰显示肠系膜上动脉病变,确定其病变性质,了解其累及范围,为临床诊治提供有力的影像学依据。%Objective To evaluate the image features of isolated superior mesenteric artery lesion (ISMAL) by using 256 slice CT.Methods The images and clinical data of 12 patients were analyzed retrospectively. Every case was analyzed by the methods of vascular reconstruction, such as plain scan transverse axial, enhanced scan transverse axis, the volume rendering (VR), curved planar reformation (CPR), maximum intensity projection (MIP), and summarize the imaging characterization.Results The average age of ISMAL patients was (50.1±2.7)years old, 9 male (75%), 3 female (25%), the prevalence's of SMAD are higher among men than women. 8 patients were superior mesenteric artery embolism (SAME) including5 male and 3 female. 4 patients were superior mesenteric artery dissection (SMAD), all of them were male. The appearance of SMAE were filling defect in arteries and luminal local broadening. The typical manifestation of SMAD was the double chamber display of the strip and

  3. 256层螺旋CT一站式重建诊断颈椎病的临床应用%Clinical Application of 256-Slice CT One-stop Reconstruction Examines in Cervical Spondylosis

    Institute of Scientific and Technical Information of China (English)

    田树平; 王占宇; 王守海; 林井副; 张燕群; 郭勇

    2011-01-01

    Purpose To evaluate the clinical application value of 256 slices CT onestop reconstruction exanunes in cervical spondylosis. Materials and Methods 500 patients with clinical suspicious cervical spondylosis undertook CT volumetric scanning. Then imitation routine intervertebral discs examination and one-stop reconstruction including VR, MPR and CMPR were performed at EBW4.0 workstation. 15 signs related to cervical spondylosis including cervical curvature abnormalitie, cervical sequences abnormalities, cervical vertebral bone hyperplasia, abnormal facet joints, Luschka joint hyperplasia, bony spinal stenosis. abnormal transverse foramen, intervertebral space narrowing, lateral recess stenosis, vertebral Schmorl's nodules, intervertebral disc abnormalities, paraspinal soft tissue abnormalities, nerve root compression, anterior /posterior longitudinal ligament ossification, and nuchal ligament ossification were observed and compared in two modes, χ2 test was used to detect the differences between the two modes. Results There were no statistic differences of paraspinal soft tissue abnormalities (P =0.500), cervical sequences abnormalitie (P = 0.499), abnormal transverse foramen (P = 0.685), lateral recess stenosis (P = 0.447), and nuchal ligament ossification (P = 0.346) between the two modes (P > 0.05).There were statistic differences of other indexes (P < 0.05). Conclusion 256-slice CT one-stop reconstruction examines can accurately detect more signs of cervical spondylosis compared with CT conventional examinations.%目的 探讨256层螺旋CT一站式重建诊断颈椎病的应用价值.资料与方法 对500例临床拟诊为颈椎病的患者进行颈椎容积扫描后在EBW4.0工作站进行模拟常规椎问盘扫描重建及一站式重建[包括容积再现(VR)、多平面重组(MPR)及曲而重组(CMPR)],分别观察并比较两种扣描模式对颈椎曲度、颈椎序列、颈椎椎体骨质增生、椎小关节异常、钩椎关节增生、骨性椎

  4. Analysis of 256 patients with Nevus of Ota treated by MedliteC3 system%MedliteC3激光治疗太田痣256例分析

    Institute of Scientific and Technical Information of China (English)

    李任; 金岚; 陈朗

    2009-01-01

    目的:观察MedliteC3激光治疗太田痣的临床疗效,总结治疗体会.方法:对256例太田痣患者以1064nm波长激光进行治疗.结果:显效率在治疗3次以后达到91.41%,治愈率在治疗5次以后达到72.27%,7次以后达97.27%.结论:MedilteC3激光对于太田痣治疗具有良好的效果,值得推广应用.

  5. Initial experience of whole-brain perfusion imaging performed with 256-slice CT%256层螺旋CT全脑灌注成像的初步研究

    Institute of Scientific and Technical Information of China (English)

    唐健; 姜建威; 常军; 侯海燕; 姜旭栋; 堵红群

    2011-01-01

    目的:初步评价256层螺旋CT全脑灌注成像对正常脑血流动力学测定的可行性和价值.方法:从拟诊缺血性脑病行头颅平扫、头颅灌注成像及头颈部血管成像的114例患者中选取检查结果正常者35例,记录头颅灌注成像的辐射剂量,由两名高年资神经放射科医生分别对灌注图像进行分析,选择基底节层面和侧脑室体部层面的两侧大脑中动脉供血区的颞叶皮质进行测定,通过手动勾画选定层面的感兴趣区,CT灌注软件自动生成感兴趣区的脑血流量(CBF)、脑血容量(CBV)、平均通过时间(MTr)、达峰时间(TTP)值,测得的灌注参数均值进行单因素方差分析.结果:35例正常人的辐射剂量为(2.307±0.008)mSv.2名分析者所测得侧脑室体部层面和基底节层面的颞叶灰质的CBF、CBV、MTr、TTP值之间无明显统计学差异(P>0.05).2名分析者测得的两个层面的颞叶灰质的CBV、CBF值之间均有统计学差异(P<0.05).结论:256层螺旋CT全脑灌注成像辐射剂量低,脑灌注参数稳定,能够更真实的反应全脑血流动力学改变.%Objective;To preliminarily evaluate the feasibility and potential values of whole-brain perfusion imaging performed with 256-slice CT to assess normal adult cerebral hemodynamics. Methods; Thirty-five normal results were selected from one hundred and fourteen patients who underwent brain CT unenhanced scan.CT perfusion imaging and CT angiography in head and neck for suspicion of ischemic cerebrovascular disease. The radiation dosage of CT perfusion imaging was recorded. Two senior neuroradiologic doctors independently analyzed the CT perfusion maps. Region of interest (ROI) was placed on bilateral temporal gray matter of two slices (the basal ganglia slice and body of lateral cerebral ventricle slice) supplied by middle cerebral artery,and the cerebral blood flow(CBF),cerebral blood volume(CBV),mean transiting time(MTT), and time to peak(TTP) values of ROI

  6. The preliminary study of 256-slice spiral CT for coronary artery angiography%256层螺旋CT冠状动脉成像技术初步研究

    Institute of Scientific and Technical Information of China (English)

    马荣希; 王祺; 李晓辉; 孙伯章; 李林萌; 樊淑青; 朱晓伟

    2013-01-01

    Objective To evaluate the feasibility and clinical value of non-invasive 256-slice spiral CT angiography (CTA) in the large-scale population screening and patients reviewing. Methods 2 200 patients who were suspected or confirmed the diagnosis of coronary heart disease underwent 256-slice spiral CTA examination. The image quality was e-valuated and graded, also the possible influencing factors were analyzed. Results Of all 2 200 cases, there were 2 000 cases (group A) with suspected coronary atherosclerotic heart diseases and 200 reviewed cases (group B) after surgery of which 16 cases with coronary artery bypass surgery and 184 cases with stent implantation. For 2 200 cases, the overall success rate was 98. 0% , image quality as excellent, good, fair and poor were 41. 6% , 40. 3%, 16. 1 % and 2. 0% respectively. For group A, success rate was 98. 2% , image quality as excellent in 846 cases, accounting for 42. 3% , good in 797 cases, accounting for 39. 85% , fair in 321 cases, accounting for 16. 05% , and poor in 36 cases, accounting for 1. 8%. For group B, success rate was 96. 5% , excellent in 70 cases (35. 0%), good in 89 cases (44. 5%), fair in 34 cases (17. 0%) , and poor in 7 cases (3. 5%). The influences of breathing, heart rate, calcification and obesity on image quality were 53.8%, 20.9%, 13.4%, 11.9% respectively. Conclusion The quality of breath holding and emotional stability were the primary factors that affect the image quality, and well preparation before scanning is the key to success. The coronary CTA imaging technology with 256-slice CT could meet the clinical needs and can be used for screening, diagnosing and reassessing of coronary heart disease in the large-scale population.%目的 探讨利用256层螺旋CT冠状动脉成像进行冠心病大范围筛查及复查的可行性及临床价值.方法 使用飞利浦256层螺旋CT对临床拟诊冠心病及已确诊冠心病的复查患者共2 200例进行冠脉CTA扫描,对图像质量进行评

  7. 基于FPGA的256位CPU中定点算术逻辑器件的设计

    Institute of Scientific and Technical Information of China (English)

    朱伟

    2016-01-01

    文章首次提出了一种由FPGA构成的256位定点算术逻辑ALU,此ALU器件运行速度快结构简单,而且占用硬件资源少,此ALU器件基于现场可编程门阵列来构成,使用VHDL语言模块化的设计实现,可以将器件设计为独立的IP核,能够嵌入到各种宽位CPU中完成高性能计算机内核的设计。

  8. Purification and Characterization of a Dimethoate-Degrading Enzyme of Aspergillus niger ZHY256, Isolated from Sewage

    Science.gov (United States)

    Liu, Yu-Huan; Chung, Ying-Cheng; Xiong, Ya

    2001-01-01

    A dimethoate-degrading enzyme from Aspergillus niger ZHY256 was purified to homogeneity with a specific activity of 227.6 U/mg of protein. The molecular mass of the purified enzyme was estimated to be 66 kDa by gel filtration and 67 kDa by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The isoelectric point was found to be 5.4, and the enzyme activity was optimal at 50°C and pH 7.0. The activity was inhibited by most of the metal ions and reagents, while it was induced by Cu2+. The Michaelis constant (Km) and Vmax for dimethoate were 1.25 mM and 292 μmol min−1 mg of protein−1, respectively. PMID:11472959

  9. 256-pixel microcalorimeter array for high-resolution γ-ray spectroscopy of mixed-actinide materials

    Energy Technology Data Exchange (ETDEWEB)

    Winkler, R., E-mail: rwinkler@lanl.gov [Los Alamos National Laboratory, Los Alamos, NM (United States); Hoover, A.S.; Rabin, M.W. [Los Alamos National Laboratory, Los Alamos, NM (United States); Bennett, D.A.; Doriese, W.B.; Fowler, J.W.; Hays-Wehle, J.; Horansky, R.D.; Reintsema, C.D.; Schmidt, D.R.; Vale, L.R.; Ullom, J.N. [National Institute of Standards and Technology, Boulder, CO (United States)

    2015-01-11

    The application of cryogenic microcalorimeter detectors to γ-ray spectroscopy allows for measurements with unprecedented energy resolution. These detectors are ideally suited for γ-ray spectroscopy applications for which the measurement quality is limited by the spectral overlap of many closely spaced transitions using conventional detector technologies. The non-destructive analysis of mixed-isotope Pu materials is one such application where the precision can be potentially improved utilizing microcalorimeter detectors compared to current state-of-the-art high-purity Ge detectors (HPGe). The LANL-NIST γ-ray spectrometer, a 256-pixel microcalorimeter array based on transition-edge sensors (TESs), was recently commissioned and used to collect data on a variety of Pu isotopic standards to characterize the instrument performance. These measurements represent the first time the simultaneous readout of all 256 pixels for measurements of mixed-isotope Pu materials has been achieved. The LANL-NIST γ-ray spectrometer has demonstrated an average pixel resolution of 55 eV full-width-at-half-maximum at 100 keV, nearly an order of magnitude better than HPGe detectors. Some challenges of the analysis of many-channel ultra-high resolution data and the techniques used to produce quality spectra for isotopic analysis will be presented. The LANL-NIST γ-ray spectrometer has also demonstrated stable operation and obtained high resolution measurements at total array event rates beyond 1 kHz. For a total event rate of 1.25 kHz, approximately 5.6 cps/pixel, a 72.2 eV average FWHM for the 103 keV photopeak of {sup 153}Gd was achieved.

  10. Experimental Comparison of Gains in Achievable Information Rates from Probabilistic Shaping and Digital Backpropagation for DP-256QAM/1024QAM WDM Systems

    DEFF Research Database (Denmark)

    Porto da Silva, Edson; Yankov, Metodi Plamenov; Da Ros, Francesco;

    2016-01-01

    Gains in achievable information rates from probabilistic shaping and digital backpropagation are compared for WDM transmission of 5 × 10 GBd DP-256QAM/1024QAM up to 1700 km of reach. The combination of both techniques its shown to provide gains of up to ∼0.5 bits/QAM symbol...

  11. Mutations of residues 249 and 256 in VP2 are involved in the replication and virulence of infectious Bursal disease virus.

    Directory of Open Access Journals (Sweden)

    Xiaole Qi

    Full Text Available Infectious bursal disease virus (IBDV is a pathogen of worldwide significance to the poultry industry. Although the PDE and PFG domains of the capsid protein VP2 contribute significantly to virulence and fitness, the detailed molecular basis for the pathogenicity of IBDV is still not fully understood. Because residues 253 and 284 of VP2 are not the sole determinants of virulence, we hypothesized that other residues involved in virulence and fitness might exist in the PDE and PFG domains of VP2. To test this, five amino acid changes selected by sequence comparison of the PDE and PFG domains of VP2 were introduced individually using a reverse genetics system into the virulent strain (rGx-F9VP2. Then reverse mutations of the selected residues 249 and 256 were introduced individually into the attenuated strain (rGt. Seven modified viruses were generated and evaluated in vitro (CEF cells and in vivo (SPF chicken. For residue 249, Q249R could elevate in vitro and reduce in vivo the replication of rGx-F9VP2 while R249Q could reduce in vitro and elevate in vivo the replication of rGt; meanwhile Q249R reduced the virulence of rGx-F9VP2 while R249Q increased the virulence of rGt, which indicated that residue 249 significantly contributed to the replication and virulence of IBDV. For residue 256, I256V could elevate in vitro and reduce in vivo the replication of rGx-F9VP2 while V256I could reduce in vitro but didn't change in vivo the replication of rGt; although V256I didn't increase the virulence of rGt, I256V obviously reduced the virulence of virulent IBDV. The present results demonstrate for the first time, to different extent, residues 249 and 256 of VP2 are involved in the replication efficiency and virulence of IBDV; this is not only beneficial to further understanding of pathogenic mechanism but also to the design of newly tailored vaccines against IBDV.

  12. 256-Slice CT perfusion imaging in transcatheter arterial chemoembolization for hepatocellular carcinoma%256层CT全肝灌注成像在原发性肝癌肝动脉化疗栓塞术中的价值

    Institute of Scientific and Technical Information of China (English)

    黄丽娜; 倪衡建; 姜建威; 殷允娟; 侯海燕

    2015-01-01

    Objective To explore the clinical value of 256-slice CT whole hepatic perfusion imaging in transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).Methods Twenty-three patients with hepatocellular carcinoma underwent whole hepatic perfusion with the JOG technique one week before TACE.The scanning data of cancer and liver tissues were analyzed using the perfusion software.The cancer tissue perfusion was repeated 4 to 6 weeks after treatment and was compared with that before treatment.Results (1) Before TACE,the HCC lesions were shown on the hepatic arterial perfusion (HAP) map as homogeneous hyper-perfusion lesions in 8 patients and as inhomogeneous hyper-perfusion lesions in 15 patients.The HAP and hepatic arterial perfusion index (HAPI) values of the tumor were higher than those of the liver tissues,while the hepatic portal perfusion (HPP) values of the tumor was lower than that of the liver tissues.The differences were all significant (P < 0.05).(2) Mter TACE,the tumors were totally filled with lipiodol in 3 patients,partially filled with lipiodol in 13 patients,and sparsely filled with lipiodol in the remaining 3 patients.There was no blood perfusion in the lipiodol-filled areas and in the cancer necrotic tissues,but in the sparsely or partially lipiodol-filled areas blood perfusion could still be seen.21 patients received another session of TACE 6 to 8 weeks later.The results between the hepatic arterial digital subtraction angiography (DSA) and the CT perfusion were 100% matching.The HAP and HAPI values of the tumor decreased when compared with before treatment,and the difference was significant (both P <0.05).The HPP values decreased slightly with no significant difference (P > 0.05),while higher HAP and HPI and lower HPP were observed in the active cancer tissues when compared with the liver tissues after treatment (P < 0.05).Conclusion 256-slice MSCT whole liver perfusion imaging can quantitatively reflect abnormal

  13. 利用256iCT对正常人左心房相关参数定量研究%The application of 256 iCT in quantitative study on the left atrial related parameters

    Institute of Scientific and Technical Information of China (English)

    李敬民; 李彩英; 李庆啸; 赵爽; 刘晓伟; 王伟

    2013-01-01

    目的 应用256 iCT对左心房结构和功能相关参数定量研究.方法选择506例行256 iCT冠状动脉CTA检查结果正常的患者影像资料,所选患者近6个月之内均无心血管疾病病史.确定左心室收缩末期和舒张末期,分别测量左心房最大容积(LAVmax)、左心房最小容积(LAVmin)、左心房最大前后径(LADmax)、左心房最小前后径(LADmin),左心房前壁厚度(LAT),并计算出左心房容积指数(LAVI)和左心房射血分数(LAEF),进行相关统计学处理.结果 正常人LAVmax、LAVmin、LADmax、LADmin、LAT、LAVI以及LAEF的95%医学参考值范围分别为:15.64~82.78 mL、9.78~51.34 mL、25.75~50.87 mm、20.99~45.34 mm、1.17~3.15 mm、18.90~39.32 mL/m2 、24.65%~52.63%.LAVmax、LAVmin、LADmin值在不同年龄组之间有统计学差异(P<0.05),40岁以上人群>40岁以下人群.不同性别之间LAVmax、LAVmin有统计学差异(P<0.05),男性大于女性,其余各参数男女之间均无差异(P>0.05).LAVmax、LAVmin与年龄相关,随着年龄增长有增大趋势(P<0.05).LAVI、LAEF在不同年龄、性别之间均无明显差异.结论 本研究初步建立了正常人左心房相关参数的医学参考值,为临床评估左心房解剖结构和功能提供了参考标准.%Objective To assess the reference values for the normal left atrial construction and function using by 256 iCT. Methods 506 patients who underwent 256 iCT coronary artery CTA with negative results and normal physical examination were selected. All individuals had no history of cardiac disease in the past six months. After confirming left ventricular end-systole and end-diastole, the following parameters were measured: left atrial maximal volume ( LAVmax) , left atrial minimal volume (LAVmin) , left atrial maximal anterior posterior diameter (LADmax) , left atrial minimal anterior posterior diameter (LADmin) , left atrial wall thickness (LAT),then left atrial volume index( LAVI) and left atrial ejection

  14. Optimal temporal windows and dose-reducing strategy for coronary artery bypass graft imaging with 256-slice CT

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Kun-Mu [Department of Radiology, Shin Kong Wu Ho-Su Memorial Hospital, 95 Wen Chang Road, Shih Lin District, Taipei 111, Taiwan. (China); Lee, Yi-Wei [Department of Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (China); Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan (China); Guan, Yu-Xiang [Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan (China); Chen, Liang-Kuang [Department of Radiology, Shin Kong Wu Ho-Su Memorial Hospital, 95 Wen Chang Road, Shih Lin District, Taipei 111, Taiwan. (China); School of Medicine, Fu Jen Catholic University, Taipei, Taiwan (China); Law, Wei-Yip, E-mail: m002325@ms.skh.org.tw [Department of Radiology, Shin Kong Wu Ho-Su Memorial Hospital, 95 Wen Chang Road, Shih Lin District, Taipei 111, Taiwan. (China); Su, Chen-Tau, E-mail: m005531@ms.skh.org.tw [Department of Radiology, Shin Kong Wu Ho-Su Memorial Hospital, 95 Wen Chang Road, Shih Lin District, Taipei 111, Taiwan. (China); School of Medicine, Fu Jen Catholic University, Taipei, Taiwan (China)

    2013-12-11

    Objective: To determine the optimal image reconstruction windows in the assessment of coronary artery bypass grafts (CABGs) with 256-slice computed tomography (CT), and to assess their associated optimal pulsing windows for electrocardiogram-triggered tube current modulation (ETCM). Methods: We recruited 18 patients (three female; mean age 68.9 years) having mean heart rate (HR) of 66.3 beats per minute (bpm) and a heart rate variability of 1.3 bpm for this study. A total of 36 CABGs with 168 segments were evaluated, including 12 internal mammary artery (33.3%) and 24 saphenous vein grafts (66.7%). We reconstructed 20 data sets in 5%-step through 0–95% of the R–R interval. The image quality of CABGs was assessed by a 5-point scale (1=excellent to 5=non-diagnostic) for each segment (proximal anastomosis, proximal, middle, distal course of graft body, and distal anastomosis). Two reviewers discriminated optimal reconstruction intervals for each CABG segment in each temporal window. Optimal windows for ETCM were also evaluated. Results: The determined optimal systolic and diastolic reconstruction intervals could be divided into 2 groups with threshold HR=68. The determined best reconstruction intervals for low heart rate (HR<68) and high heart rate (HR>68) were 76.0±2.5% and 45.0±0% respectively. Average image quality scores were 1.7±0.6 with good inter-observer agreement (Kappa=0.79). Image quality was significantly better for saphenous vein grafts versus arterial grafts (P<0.001). The recommended windows of ETCM for low HR, high HR and all HR groups were 40–50%, 71–81% and 40–96% of R-R interval, respectively. The corresponding dose savings were about 60.8%, 58.7% and 22.7% in that order. Conclusions: We determined optimal reconstruction intervals and ETCM windows representing a good compromise between radiation and image quality for following bypass surgery using a 256-slice CT.

  15. The association between the brain and mind pops: a voxel-based morphometry study in 256 Chinese college students.

    Science.gov (United States)

    Zhang, Lei; Li, Wenfu; Wei, Dongtao; Yang, Wenjing; Yang, Ning; Qiao, Lei; Qiu, Jiang; Zuo, Xi-Nian; Zhang, Qinglin

    2016-06-01

    Mind pops or involuntary semantic memories refer to words, phrases, images, or melodies that suddenly pop into one's mind without any deliberate attempt to recall them. Despite their prevalence in everyday life, research on mind pops has started only recently. Notably, mind pops are very similar to clinical involuntary phenomena such as hallucinations in schizophrenia, suggesting their potential role in pathology. The present study aimed to investigate the relationship between mind pops and the brain morphometry measured in 302 healthy young adults; after exclusions, 256 participants were included in our analyses. Specifically, the Mind Popping Questionnaire (MPQ) was employed to measure the degree of individual mind pops, whereas the Voxel-Based Morphometry (VBM) was used to compute the volumes of both gray and white matter tissues. Multiple regression analyses on MPQ and VBM metrics indicated that high-frequency mind pops were significantly associated with smaller gray matter volume in the left middle temporal gyrus as well as with larger gray and white matter volume in the right medial prefrontal cortex. This increase in mind pops is also linked to higher creativity and the personality trait of 'openness'. These data not only suggest a key role of the two regions in generating self-related thoughts, but also open a possible link between brain and creativity or personality.

  16. A Re-configurable On-line Learning Spiking Neuromorphic Processor comprising 256 neurons and 128K synapses

    Directory of Open Access Journals (Sweden)

    Ning eQiao

    2015-04-01

    Full Text Available Implementing compact, low-power artificial neural processing systems with real-time on-line learning abilities is still an open challenge. In this paper we present a full-custom mixed-signal VLSI device with neuromorphic learning circuits that emulate the biophysics of real spiking neurons and dynamic synapses for exploring the properties of computational neuroscience models and for building brain-inspired computing systems. The proposed architecture allows the on-chip configuration of a wide range of network connectivities, including recurrent and deep networks with short-term and long-term plasticity. The device comprises 128 K analog synapse and 256 neuron circuits with biologically plausible dynamics and bi-stable spike-based plasticity mechanisms that endow it with on-line learning abilities. In addition to the analog circuits, the device comprises also asynchronous digital logic circuits for setting different synapse and neuron properties as well as different network configurations. This prototype device, fabricated using a 180 nm 1P6M CMOS process, occupies an area of 51.4 mm 2 , and consumes approximately 4 mW for typical experiments, for example involving attractor networks. Here we describe the details of the overall architecture and of the individual circuits and present experimental results that showcase its potential. By supporting a wide range of cortical-like computational modules comprising plasticity mechanisms, this device will enable the realization of intelligent autonomous systems with on-line learning capabilities.

  17. 256层极速CT肾动脉血管成像图像质量影响分析%Analysis of the Quality Influence Factors of Renal Artery Imaging by Speed CT 256

    Institute of Scientific and Technical Information of China (English)

    华建东; 陈伟斌; 杨小兰; 刘孜卓; 张惠英

    2015-01-01

    Objective To observe impact of the 256 speed CTA on the imaging quality of renal artery and its branches by applying different concentrations of contrast agent and adopting different injection rate. Method 336 cases with renal artery CTA examination in our hospital were observed, and they were divided, according to different concentration and the injection rate, into 3 groups with 112 cases in each group. The injection rate of Group A, Group B and Group C was 5 mL/s (iopamidol, 350), 4 mL/s (iopamidol, 350) and 5 mL/s (ioversol, 370) respectively. The dosage was 50 mL for each group. The image quality and display rate of blood vessels were compared through the classification of renal artery branch. Results With the same concentration of contrast agent, renal artery branch of Level II, III, IV, V, VI of Group A was better than that of Group B, with statistically significant difference. At the same injection rate, renal artery branch of Level IV, V, VI of Group C was better than that of Group A, with statistical difference as well. Conclusion As for the CTA image quality and of vascular imaging display rate of the renal artery branches, the greater dosing speed and the higher concentration can cause better effect.%目的:研究256层极速CTA应用不同浓度对比剂及采取不同注药速率,对肾动脉及其分支成像质量的影响。方法观察本院行肾动脉CTA检查患者336例,按注药浓度和速率分组,每组112例。 A组:注药速率5.0 mL/s (碘帕醇350); B组:注药速率4.0 mL/s (碘帕醇350); C组:注药速率5.0 mL/s (碘佛醇370),用药剂量均为50 mL。通过对肾动脉分支分级比较图像质量及血管显示率效果。结果在对比剂浓度相同情况下,肾动脉分支II、 III、 IV、 V、 VI级A组均优于B组,具有统计学差异。在注药速率相同情况下,肾动脉分支IV、 V、 VI级C组均优于A组,具有统计学差异。结论对肾动脉细小分支CTA 图像质量及血

  18. 256层CT灌注成像和三维重建对乳腺疾病诊断的临床价值%The clinical value of 256 slice CT perfusion imaging and three-dimensional reconstruction of breast disease

    Institute of Scientific and Technical Information of China (English)

    姜敏; 张刚庆; 高鹏; 李武铭; 温建燔; 张国伟

    2015-01-01

    Objective To explore the significance of 256 slice CT perfusion imaging and three-dimensional reconstruction technology for diagnosis and preoperative evaluation of breast disease. Methods 50 patients found breast tumors by color doppler ultrasound or mammography underwent 256 slice CT perfusion scan, combined with the postoperative pathological results, analyzed the perfusion imaging indexes of different nature of breast neoplasm tissue and normal breast tissue, and three-dimensional reconstruction of guidance for clinical surgery. Results The perfusion imaging indexes of 256 slice CT had important reference value in differential diagnosis of benign and malignant breast tumors, three- dimensional reconstruction model could observe lesions in all situations, and provided the basis for preoperative assessment. Conclusion 256 slice CT perfusion imaging can be helpful to differentiate the breast cancer from benign breast tumor from the aspects of hemodynamics. three-dimensional reconstruction can provide more information for clinical diagnosis, treatment, and help to preoperative evaluation of breast cancer.%目的:探讨256层CT灌注成像和三维重建技术对乳腺疾病诊断和术前评估的意义。方法采用256层CT对50例经彩超或钼靶发现有乳腺肿物的患者进行灌注扫描,结合术后病理结果,分析不同性质乳腺肿瘤组织和正常乳腺组织的灌注成像指标,以及乳腺三维重建对临床手术的指导作用。结果256层CT灌注成像指标值对鉴别诊断乳腺良恶性肿瘤具有重要的参考价值;三维重建模型可以全方位地观察病灶情况,为术前评估提供了依据。结论256层CT灌注成像能从血流动力学方面鉴别诊断乳腺良恶性肿瘤;三维重建可为临床诊断、治疗提供更多的信息,有助于乳腺癌的术前评估。

  19. Interpretations of systematic errors in the NCEP Climate Forecast System at lead times of 2, 4, 8, ..., 256 days

    Directory of Open Access Journals (Sweden)

    Siwon Song

    2012-09-01

    Full Text Available The climatology of mean bias errors (relative to 1-day forecasts was examined in a 20-year hindcast set from version 1 of the Climate Forecast System (CFS, for forecast lead times of 2, 4, 8, 16, ... 256 days, verifying in different seasons. Results mostly confirm the simple expectation that atmospheric model biases should be evident at short lead (2–4 days, while soil moisture errors develop over days-weeks and ocean errors emerge over months. A further simplification is also evident: surface temperature bias patterns have nearly fixed geographical structure, growing with different time scales over land and ocean. The geographical pattern has mostly warm and dry biases over land and cool bias over the oceans, with two main exceptions: (1 deficient stratocumulus clouds cause warm biases in eastern subtropical oceans, and (2 high latitude land is too cold in boreal winter. Further study of the east Pacific cold tongue-Intertropical Convergence Zone (ITCZ complex shows a possible interaction between a rapidly-expressed atmospheric model bias (poleward shift of deep convection beginning at day 2 and slow ocean dynamics (erroneously cold upwelling along the equator in leads > 1 month. Further study of the high latitude land cold bias shows that it is a thermal wind balance aspect of the deep polar vortex, not just a near-surface temperature error under the wintertime inversion, suggesting that its development time scale of weeks to months may involve long timescale processes in the atmosphere, not necessarily in the land model. Winter zonal wind errors are small in magnitude, but a refractive index map shows that this can cause modest errors in Rossby wave ducting. Finally, as a counterpoint to our initial expectations about error growth, a case of non-monotonic error growth is shown: velocity potential bias grows with lead on a time scale of weeks, then decays over months. It is hypothesized that compensations between land and ocean errors may

  20. Prospective ECG triggering reduces prosthetic heart valve-induced artefacts compared with retrospective ECG gating on 256-slice CT

    Energy Technology Data Exchange (ETDEWEB)

    Symersky, Petr [Academic Medical Center, Department of Cardiothoracic Surgery, Amsterdam (Netherlands); Habets, Jesse; Budde, Ricardo P.J. [University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands); Westers, Paul [University Medical Center Utrecht, Department of Biostatistics, Julius Center for Health Sciences and Primary Care, Utrecht (Netherlands); Mol, Bas A.J.M. de [Academic Medical Center, Department of Cardiothoracic Surgery, Amsterdam (Netherlands); University of Technology Eindhoven, Department of Biomedical Engineering, Eindhoven (Netherlands); Prokop, Mathias [Radboud University Nijmegen Medical Center, Department of Radiology, Nijmegen (Netherlands)

    2012-06-15

    Multidetector computed tomography (MDCT) has diagnostic value for the evaluation of prosthetic heart valve (PHV) dysfunction but it is hampered by artefacts. We hypothesised that image acquisition using prospective triggering instead of retrospective gating would reduce artefacts related to pulsating PHV. In a pulsatile in vitro model, a mono- and bileaflet PHV were imaged using 256 MDCT at 60, 75 and 90 beats per minute (BPM) with either retrospective gating (120 kV, 600 mAs, pitch 0.2, CTDI{sub vol} 39.8 mGy) or prospective triggering (120 kV, 200 mAs, CTDI{sub vol} 13.3 mGy). Two thresholds (>175 and <-45HU), derived from the density of surrounding structures, were used for quantification of hyper- and hypodense artefacts. Image noise and artefacts were compared between protocols. Prospective triggering reduced hyperdense artefacts for both valves at every BPM (P = 0.001 all comparisons). Hypodense artefacts were reduced for the monoleaflet valve at 60 (P = 0.009), 75 (P = 0.016) and 90 BPM (P = 0.001), and for the bileaflet valves at 60 (P = 0.001), 90 (P = 0.001) but not at 75 BPM (P = 0.6). Prospective triggering reduced image noise at 60 (P = 0.001) and 75 (P < 0.03) but not at 90 BPM. Compared with retrospective gating, prospective triggering reduced most artefacts related to pulsating PHV in vitro. circle Computed tomographic images are often degraded by prosthetic heart valve-induced artefacts circle Prospective triggering reduces prosthetic heart valve-induced artefacts in vitro circle Artefact reduction at 90 beats per minute occurs without image noise reduction circle Prospective triggering may improve CT image quality of moving hyperdense structures. (orig.)

  1. Optimisation of vascular input and output functions in CT-perfusion imaging using 256(or more)-slice multidetector CT

    Energy Technology Data Exchange (ETDEWEB)

    Niesten, Joris M.; Schaaf, Irene C. van der; Riordan, Alan J.; Jong, Hugo W.A.M. de; Mali, Willem P.T.M.; Velthuis, Birgitta K. [University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands)

    2013-05-15

    To evaluate the accuracy and reproducibility of CT-perfusion (CTP) by finding the optimal artery for the arterial input function (AIF) and re-evaluating the necessity of the venous output function (VOF). Forty-four acute ischaemic stroke patients who underwent non-enhanced CT, CTP and CT-angiography using 256-slice multidetector computed tomography (MDCT) were evaluated. The anterior cerebral artery (ACA), middle cerebral artery (MCA), internal carotid artery (ICA) and basilar artery were selected as the AIF. Subsequently the resulting area under the time-enhancement curve of the AIF (AUC{sub AIF}) and quantitative perfusion measurements were analysed by repeated measures ANOVA and subsequently the paired t test. To evaluate reproducibility we examined if the VOF could be deleted by comparing the perfusion measurements using versus not using the VOF (paired t test). The AUC{sub AIF} and perfusion measurements resulting from the different AIFs showed significant group differences (all P < 0.0001). The ICA had the largest AUC{sub AIF} and resulted in the highest mean transient time (MTT) and lowest cerebral blood flow (CBF), whereas the basilar artery showed the lowest cerebral blood volume (CBV). Not using the VOF showed significantly higher CBV and CBF in 66 % of patients on the ipsilateral (P < 0.0001 and P = 0.007, respectively) and contralateral hemisphere (P < 0.0001 and P = 0.019, respectively). Selecting the ICA as the AIF and continuing the use of the VOF would improve the accuracy of CTP. (orig.)

  2. 2.56 Tbit/s/ch (640 Gbaud) polarization-multiplexed DQPSK non-coherent Nyquist pulse transmission over 525 km.

    Science.gov (United States)

    Harako, Koudai; Seya, Daiki; Suzuki, Daiki; Hirooka, Toshihiko; Nakazawa, Masataka

    2015-11-30

    We demonstrate a single-channel 2.56 Tbit/s polarization-multiplexed DQPSK transmission using 640 Gbaud non-coherent optical Nyquist pulses. By virtue of a large tolerance to polarization-mode dispersion, the detrimental depolarization-induced crosstalk was reduced by 3.8 dB compared with RZ pulses. As a result, the transmission distance was substantially extended to 525 km compared with the distance of 300 km obtained with a Gaussian pulse.

  3. Whole-brain CT perfusion and CT angiography assessment of Moyamoya disease before and after surgical revascularization: preliminary study with 256-slice CT.

    Directory of Open Access Journals (Sweden)

    Jun Zhang

    Full Text Available BACKGROUND/AIMS: The 256-slice CT enables the entire brain to be scanned in a single examination. We evaluated the application of 256-slice whole-brain CT perfusion (CTP in determining graft patency as well as investigating cerebral hemodynamic changes in Moyamoya disease before and after surgical revascularization. METHODS: Thirty-nine cases of Moyamoya disease were evaluated before and after surgical revascularization with 256-slice CT. Whole-brain perfusion images and dynamic 3D CT angiographic images generated from perfusion source data were obtained in all patients. Cerebral blood flow (CBF, cerebral blood volume (CBV, time to peak (TTP and mean transit time (MTT of one hemisphere in the region of middle cerebral artery (MCA distribution and contralateral mirroring areas were measured. Relative CTP values (rCBF, rCBV, rTTP, rMTT were also obtained. Differences in pre- and post- operation perfusion CT values were assessed with paired t test or matched-pairs signed-ranks test. RESULTS: Preoperative CBF, MTT and TTP of potential surgical side were significantly different from those of contralateral side (P<0.01 for all. All graft patencies were displayed using the 3D-CTA images. Postoperative CBF, rCBF and rCBV values of surgical side in the region of MCA were significantly higher than those before operation (P<0.01 for all. Postoperative MTT, TTP, rMTT and rTTP values of the surgical side in the region of MCA were significantly lower than those before operation (P<0.05 for all. CONCLUSION: The 256-slice whole-brain CTP can be used to evaluate cerebral hemodynamic changes in Moyamoya disease before and after surgery and the 3D-CTA is useful for assessing the abnormalities of intracranial arteries and graft patencies.

  4. APOA2 -256T>C polymorphism interacts with saturated fatty acids intake to affect anthropometric and hormonal variables in type 2 diabetic patients.

    Science.gov (United States)

    Basiri, Marjan Ghane; Sotoudeh, Gity; Alvandi, Ehsan; Djalali, Mahmood; Eshraghian, Mohammad Reza; Noorshahi, Neda; Koohdani, Fariba

    2015-05-01

    Recent studies have established the interaction between APOA2 -256T>C polymorphism and dietary saturated fatty acids intake in relation to obesity on healthy individuals. In the current study, we investigate the effects of this interaction on anthropometric variables and serum levels of leptin and ghrelin in patients with type 2 diabetes. In this cross-sectional study, 737 patients with type 2 diabetes mellitus (290 males and 447 females) were recruited from diabetes clinics in Tehran. The usual dietary intake of all participants during the last year was obtained by validated semiquantitative food frequency questionnaire. APOA2 genotyping was performed by real-time PCR on genomic DNA. No significant relation was obtained by univariate analysis between anthropometric variables and APOA2 genotypes. However, after adjusting for age, gender, physical activity and total energy intake, we identified a significant interaction between APOA2-saturated fatty acids intake and body mass index (BMI). After adjusting for potential confounders, serum levels of ghrelin in CC genotype patients were significantly higher than T allele carriers (p = 0.03), whereas the case with leptin did not reveal a significant difference. The result of this study confirmed the interaction between APOA2 -256T>C polymorphism and SFAs intake with BMI in type 2 diabetic patients. In fact, homozygous patients for the C allele with high saturated fatty acids intake had higher BMI. The APOA2 -256T>C polymorphism was associated with elevated levels of serum ghrelin.

  5. 256层螺旋CT对肝泡性包虫切除术后门静脉的评价%256 slice spiral CT in the evaluation of portal vein of patients after resection of hepatic alveolar echinococcosis

    Institute of Scientific and Technical Information of China (English)

    韩淼; 鲍海华

    2016-01-01

    Objective:Using 256 slice spiral CT for hepatic alveolar echinococcosis hepatic portal vein imaging before and after resection,then to evaluate the situation of portal vein before and after the operation.Methods:We made a retrospective analysis of 20 patients with hepatic alveolar echinococcosis examined by liver CT examination.CT showed that the lesions were involved in 3 segments of the liver and above,the left and right branches or trunk of the portal vein were violated in different degrees,partial hepatectomy was performed in 20 patients,after 14~20 days performed the liver CT examination,we selected the portal phase of three period enhancement in liver to observe and evaluate,in order to compare the difference of portal vein before and after operation,measuring the diameter of the portal vein to judge the portal vein of patient and whether corresponding complications exist.Results:In 20 cases of patients before the surgery,5 patients with the left branch involved,12 patients with the right branch involved,3 patients with the both branches involved,in which 12 cases of patients with portal vein compression significantly,8 cases of patients with mild portal compression.The MSCT images showed after surgery that 20 cases of patients with portal pressure were improved,and the contrast agent filling well.The diameter measurement results showed that all patients’portal vein were broadening in different degrees,restored to normal level.Conclusion:Multi slice spiral CT can not only evaluate the preoperative portal vein in alveolar echinococcosis disease,providing operational information,but also can provide detailed imaging judgment on the recovery of residual liver portal vein after resection.%目的:利用256层螺旋CT对肝泡性包虫切除前后肝门静脉进行成像,进而对手术前后门脉情况进行评估。方法:回顾性分析行肝脏CT检查确诊为肝泡性包虫病患者20例,CT显示病灶均累及肝脏3段及以上,门脉左右支

  6. Biological, chemical and other data collected aboard the THOMAS G. THOMPSON during cruise TN256 in the Coastal Waters of SE Alaska from 2010-10-23 to 2010-11-03 (NODC Accession 0104361)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC accession 0104361 includes biological, chemical, optical, physical and underway data collected aboard the THOMAS G. THOMPSON during cruise TN256 in the Coastal...

  7. Anti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus Aspergillus sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines

    Directory of Open Access Journals (Sweden)

    Dong-Cheol Kim

    2016-04-01

    Full Text Available In the course of searching for bioactive secondary metabolites from marine fungi, TMC-256C1 was isolated from an ethyl acetate extract of the marine-derived fungus Aspergillus sp. SF6354. TMC-256C1 displayed anti-neuroinflammatory effect in BV2 microglial cells induced by lipopolysaccharides (LPS as well as neuroprotective effect against glutamate-stimulated neurotoxicity in mouse hippocampal HT22 cells. TMC-256C1 was shown to develop a cellular resistance to oxidative damage caused by glutamate-induced cytotoxicity and reactive oxygen species (ROS generation in HT22 cells, and suppress the inflammation process in LPS-stimulated BV2 cells. Furthermore, the neuroprotective and anti-neuroinflammatory activities of TMC-256C1 were associated with upregulated expression of heme oxygenase (HO-1 and nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2 in HT22 and BV2 cells. We also found that TMC-256C1 activated p38 mitogen-activated protein kinases (MAPK and phosphatidylinositol 3-kinase (PI3K/Akt signaling pathways in HT22 and BV2 cells. These results demonstrated that TMC-256C1 activates HO-1 protein expression, probably by increasing nuclear Nrf2 levels via the activation of the p38 MAPK and PI3K/Akt pathways.

  8. Automated Computer-Assisted Diagnosis of Obstructive Coronary Artery Disease in Emergency Department Patients Undergoing 256-Slice Coronary Computed Tomography Angiography for Acute Chest Pain.

    Science.gov (United States)

    Hashoul, Sharbell; Gaspar, Tamar; Halon, David A; Lewis, Basil S; Shenkar, Yuval; Jaffe, Ronen; Peled, Nathan; Rubinshtein, Ronen

    2015-10-01

    A 256-slice coronary computed tomography angiography (CCTA) is an accurate method for detection and exclusion of obstructive coronary artery disease (OBS-CAD). However, accurate image interpretation requires expertise and may not be available at all hours. The purpose of this study was to evaluate the usefulness of a fully automated computer-assisted diagnosis (COMP-DIAG) tool for exclusion of OBS-CAD in patients in the emergency department (ED) presenting with chest pain. Three hundred sixty-nine patients in ED without known coronary disease underwent 256-slice CCTA as part of the assessment of chest pain of uncertain origin. COMP-DIAG (CorAnalyzer II) automatically reported presence or exclusion of OBS-CAD (>50% stenosis, ≥1 vessel). Performance characteristics of COMP-DIAG for exclusion and detection of OBS-CAD were determined using expert reading as the reference standard. Seventeen (5%) studies were unassessable by COMP-DIAG software, and 352 patients (1,056 vessels) were therefore available for analysis. COMP-DIAG identified 33% of assessable studies as having OBS-CAD, but the prevalence of OBS-CAD on CCTA was only 18% (66 of 352 patients) by standard expert reading. However, COMP-DIAG correctly identified 61 of the 66 patients (93%) with OBS-CAD with 21 vessels (2%) with OBS-CAD misclassified as negative. In conclusion, compared to expert reading, automated computer-assisted diagnosis using the CorAnalyzer showed high sensitivity but only moderate specificity for detection of obstructive coronary disease in patients in ED who underwent 256-slice CCTA. The high negative predictive value of this computer-assisted algorithm may be useful in the ED setting.

  9. 256-slice CT angiographic evaluation of coronary artery bypass grafts: effect of heart rate, heart rate variability and Z-axis location on image quality.

    Directory of Open Access Journals (Sweden)

    Bettina M Gramer

    Full Text Available PURPOSE: The objective of this study is to assess the effect of heart rate, heart rate variability and z-axis location on coronary artery bypass graft (CABG image quality using a 256-slice computed tomography (CT scanner. METHODS: A total of 78 patients with 254 CABG (762 graft segments were recruited to undergo CABG assessment with 256-slice CT and prospective ECG-gating. Two observers rated graft segments for image quality on a 5-point scale. Quantitative measurements were also made. Logistic and cumulative link mixed models were used to assess the predictors of graft image quality. RESULTS: Graft image quality was judged as diagnostic (scores 5 (excellent, 4 (good and 3 (moderate in 96.6% of the 762 segments. Interobserver agreement was excellent (kappa ≥0.90. Graft image quality was not affected by heart rate level. However, high heart rate variability was associated with an important and significant image quality deterioration (odds ratio 4.31; p  =  0.036. Distal graft segments had significantly lower image quality scores than proximal segments (p ≤ 0.02. Significantly higher noise was noted at the origin of the mammary grafts (p  =  0.001, owing to streak artifacts from the shoulders. CONCLUSION: CABG imaging with 270-msec rotation 256-slice CT and prospective ECG-gating showed an adequate image quality in 96.6% of graft segments, and an excellent interobserver agreement. Graft image quality was not influenced by heart rate level. Image quality scores were however significantly decreased in patients with high heart rate variability, as well as in distal graft segments, which are closer to the heart.

  10. MT3250BA: a 320×256-50µm snapshot microbolometer ROIC for high-resistance detector arrays

    Science.gov (United States)

    Eminoglu, Selim; Akin, Tayfun

    2013-06-01

    This paper reports the development of a new microbolometer readout integrated circuit (MT3250BA) designed for high-resistance detector arrays. MT3250BA is the first microbolometer readout integrated circuit (ROIC) product from Mikro-Tasarim Ltd., which is a fabless IC design house specialized in the development of monolithic CMOS imaging sensors and ROICs for hybrid photonic imaging sensors and microbolometers. MT3250BA has a format of 320 × 256 and a pixel pitch of 50 µm, developed with a system-on-chip architecture in mind, where all the timing and biasing for this ROIC are generated on-chip without requiring any external inputs. MT3250BA is a highly configurable ROIC, where many of its features can be programmed through a 3-wire serial interface allowing on-the-fly configuration of many ROIC features. MT3250BA has 2 analog video outputs and 1 analog reference output for pseudo-differential operation, and the ROIC can be programmed to operate in the 1 or 2-output modes. A unique feature of MT3250BA is that it performs snapshot readout operation; therefore, the image quality will only be limited by the thermal time constant of the detector pixels, but not by the scanning speed of the ROIC, as commonly found in the conventional microbolometer ROICs performing line-by-line (rolling-line) readout operation. The signal integration is performed at the pixel level in parallel for the whole array, and signal integration time can be programmed from 0.1 µs up to 100 ms in steps of 0.1 µs. The ROIC is designed to work with high-resistance detector arrays with pixel resistance values higher than 250 kΩ. The detector bias voltage can be programmed on-chip over a 2 V range with a resolution of 1 mV. The ROIC has a measured input referred noise of 260 µV rms at 300 K. The ROIC can be used to build a microbolometer infrared sensor with an NETD value below 100 mK using a microbolometer detector array fabrication technology with a high detector resistance value (≥ 250 K

  11. La jerarquía de vínculos socioafectivos en Ilíada XXIII.1-256

    OpenAIRE

    Difabio de Raimondo, Elbia Haydée

    2001-01-01

    El artículo analiza las relaciones entre Aquiles y sus camaradas en la primera parte del canto XXIII (vv. 1-256), sobre la base de una mirada lingüístico-poética y un enfoque ético-pedagógico. Aquiles tiene dos comportamientos diferentes: como amigo y como caudillo. A Patroclo le dedica sus mejores manifestaciones de ternura y afecto. Como jefe, se dirige primero a sus camaradas más próximos, los mirmidones, y luego, según avanza el canto, a Agamenón, los nobles, las tropas, la comitiva más c...

  12. High resolution three-dimensional (256 to the 3rd) spatio-temporal measurements of the conserved scalar field in turbulent shear flows

    Science.gov (United States)

    Dahm, Werner J. A.; Buch, Kenneth A.

    Results from highly resolved three-dimensional spatio-temporal measurements of the conserved scalar field zeta(x,t) in a turbulent shear flow. Each of these experiments consists of 256 to the 3rd individual point measurements of the local instantaneous conserved scalar value in the flow. The spatial and temporal resolution of these measurements reach beyond the local Kolmogorov scale and resolve the local strain-limited molecular diffusion scale in the flow. The results clearly show molecular mixing occurring in thin strained laminar diffusion layers in a turbulent flow.

  13. 73.7 Tb/s (96 x 3 x 256-Gb/s) mode-division-multiplexed DP-16QAM transmission with inline MM-EDFA.

    Science.gov (United States)

    Sleiffer, V A J M; Jung, Y; Veljanovski, V; van Uden, R G H; Kuschnerov, M; Chen, H; Inan, B; Nielsen, L Grüner; Sun, Y; Richardson, D J; Alam, S U; Poletti, F; Sahu, J K; Dhar, A; Koonen, A M J; Corbett, B; Winfield, R; Ellis, A D; de Waardt, H

    2012-12-10

    Transmission of a 73.7 Tb/s (96 x 3 x 256-Gb/s) DP-16QAM mode-division-multiplexed signal over 119 km of few-mode fiber transmission line incorporating an inline multi mode EDFA and a phase plate based mode (de-)multiplexer is demonstrated. Data-aided 6 x 6 MIMO digital signal processing was used to demodulate the signal. The total demonstrated net capacity, taking into account 20% of FEC-overhead and 7.5% additional overhead (Ethernet and training sequences), is 57.6 Tb/s, corresponding to a spectral efficiency of 12 bits/s/Hz.

  14. Medium optimization to improve the flocculation rate of a novel compound bioflocculant, CBF-256, using response surface methodology and flocculation characters.

    Science.gov (United States)

    Ren, Dunjian; Li, Hongyang; Pu, Yuewu; Yi, Lvyun

    2013-01-01

    A novel compound bioflocculant, CBF-256, was obtained using three bacterial strains, Bacillus sp., Enterobacter sp., and Aeromonas sp., which were screened from activated sludge of a printing and dyeing wastewater treatment plant. Response surface methodology was employed to optimize the fermentation medium dosage to improve the flocculation rate of CBF-256, which increased from 69.00% to 82.65%. In addition the yield of the compound bioflocculant increased from 2.31 g·L(-1) to 2.84 g·L(-1). The flocculating efficiency distribution of the components of the culture broth indicated that the supernatant was the most effective component in the flocculation process. Fourier transform infrared spectroscopy and scanning electron microscopy were used to analyze the fermentation medium and composite bacteria. The compound flocculants were produced easily, and during the flocculation process, all the flocculation ingredients settled down in the remaining sludge along with the bacteria screened from the activated sludge, without causing secondary pollution.

  15. 256-slice CT coronary angiography in atrial fibrillation: The impact of mean heart rate and heart rate variability on image quality

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Liang-Kuang [Department of Radiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); College of Medicine, Fu Jen Catholic University, Taipei, Taiwan (China); Hsu, Shih-Ming [Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan (China); Mok, Greta S.P. [Department of Electrical and Electronics Engineering, Faculty of Science and Technology, University of Macau, Macau (China); Law, Wei-Yip; Lu, Kun-Mu [Department of Radiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); Yang, Ching-Ching, E-mail: g39220003@yahoo.com.tw [Department of Radiological Technology, Tzu Chi College of Technology, 880, Sec.2, Chien-kuo Rd. Hualien 970, Taiwan (China); Wu, Tung-Hsin, E-mail: tung@ym.edu.tw [Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, 155 Li-Nong St., Sec. 2, Taipei 112, Taiwan (China)

    2011-08-21

    Objective: The aim of this study was to evaluate the image quality of 256-MDCT in atrial fibrillation and to compare the findings with those among patients in sinus rhythm. Materials: All reconstructed images were evaluated by two independent experienced readers blinded to patient information, heart rate, and ECG results to assess the diagnostic quality of images of the coronary artery segments using axial images, multi-planar reformations, maximum intensity projections, and volume rendering technique. Results: No statistical significance was detected in terms of the overall image quality between patients in sinus rhythm and with atrial fibrillation. Pearson's correlation analysis showed no significant association between image quality and mean heart rate no matter for patients in sinus rhythm or with atrial fibrillation. Similarly, there was no correlation between image quality and heart rate variability for either patients in sinus rhythm or with atrial fibrillation. Our results showed that the optimal reconstruction window depends on patient's HR, and the pattern for patients in atrial fibrillation is similar to that obtained from non-atrial fibrillation patients. Conclusion: This study shows the potential of using 256-MDCT coronary angiography in patients with atrial fibrillation. Our results suggest that when appropriate reconstruction timing window is applied, patients with atrial fibrillation do not have to be excluded from MDCT coronary angiographic examinations.

  16. 256-slice CT coronary angiography in atrial fibrillation: The impact of mean heart rate and heart rate variability on image quality

    Science.gov (United States)

    Chen, Liang-Kuang; Hsu, Shih-Ming; Mok, Greta S. P.; Law, Wei-Yip; Lu, Kun-Mu; Yang, Ching-Ching; Wu, Tung-Hsin

    2011-08-01

    The aim of this study was to evaluate the image quality of 256-MDCT in atrial fibrillation and to compare the findings with those among patients in sinus rhythm.MaterialsAll reconstructed images were evaluated by two independent experienced readers blinded to patient information, heart rate, and ECG results to assess the diagnostic quality of images of the coronary artery segments using axial images, multi-planar reformations, maximum intensity projections, and volume rendering technique.ResultsNo statistical significance was detected in terms of the overall image quality between patients in sinus rhythm and with atrial fibrillation. Pearson's correlation analysis showed no significant association between image quality and mean heart rate no matter for patients in sinus rhythm or with atrial fibrillation. Similarly, there was no correlation between image quality and heart rate variability for either patients in sinus rhythm or with atrial fibrillation. Our results showed that the optimal reconstruction window depends on patient's HR, and the pattern for patients in atrial fibrillation is similar to that obtained from non-atrial fibrillation patients.ConclusionThis study shows the potential of using 256-MDCT coronary angiography in patients with atrial fibrillation. Our results suggest that when appropriate reconstruction timing window is applied, patients with atrial fibrillation do not have to be excluded from MDCT coronary angiographic examinations.

  17. Quantitative assessment of right ventricular function and pulmonary regurgitation in surgically repaired tetralogy of Fallot using 256-slice CT: comparison with 3-Tesla MRI

    Energy Technology Data Exchange (ETDEWEB)

    Yamasaki, Yuzo; Yonezawa, Masato; Matsuo, Yoshio; Kamitani, Takeshi; Higuchi, Ko; Honda, Hiroshi [Graduate School of Medical Sciences, Kyushu University, Department of Clinical Radiology, Higashi-ku, Fukuoka (Japan); Nagao, Michinobu; Kawanami, Satoshi [Graduate School of Medical Sciences, Kyushu University, Department of Molecular Imaging and Diagnosis, Higashi-ku, Fukuoka (Japan); Yamamura, Kenichiro [Graduate School of Medical Sciences, Kyushu University, Department of Pediatrics, Higashi-ku, Fukuoka (Japan); Sakamoto, Ichiro [Graduate School of Medical Sciences, Kyushu University, Department of Cardiovascular Medicine, Higashi-ku, Fukuoka (Japan); Shiokawa, Yuichi [Graduate School of Medical Sciences, Kyushu University, Department of Cardiovascular Surgery, Higashi-ku, Fukuoka (Japan); Yabuuchi, Hidetake [Graduate School of Medical Sciences, Kyushu University, Department of Health Sciences, Higashi-ku, Fukuoka (Japan)

    2014-12-15

    To compare 256-slice cardiac computed tomography (CCT) with cardiac magnetic resonance (CMR) imaging to assess right ventricular (RV) function and pulmonary regurgitant fraction (PRF) in patients with repaired tetralogy of Fallot (TOF). Thirty-three consecutive patients with repaired TOF underwent retrospective ECG-gated CCT and 3-Tesla CMR. RV and left ventricular (LV) end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) were measured using CCT and CMR. PRF-CCT (%) was defined as (RVSV - LVSV)/RVSV. PRF-CMR (%) was measured by the phase-contrast method. Repeated measurements were performed to determine intra- and interobserver variability. CCT measurements, including PRF, correlated highly with the CMR reference (r = 0.71-0.96). CCT overestimated RVEDV (mean difference, 17.1 ± 2.9 ml), RVESV (12.9 ± 2.1 ml) and RVSV (4.2 ± 2.0 ml), and underestimated RVEF (-2.6 ± 1.0 %) and PRF (-9.1 ± 2.0 %) compared with CMR. The limits of agreement between CCT and CMR were in a good range for all measurements. The variability in CCT measurements was lower than those in CMR. The estimated effective radiation dose was 7.6 ± 2.6 mSv. 256-slice CCT can assess RV function and PRF with relatively low dose radiation exposure in patients with repaired TOF, but overestimates RV volume and underestimates PRF. (orig.)

  18. Whole-organ CT perfusion of the pancreas: impact of iterative reconstruction on image quality, perfusion parameters and radiation dose in 256-slice CT-preliminary findings.

    Directory of Open Access Journals (Sweden)

    Qian Xie

    Full Text Available BACKGROUND: This study was performed to assess whether iterative reconstruction can reduce radiation dose while maintaining acceptable image quality, and to investigate whether perfusion parameters vary from conventional filtered back projection (FBP at the low-tube-voltage (80-kVp during whole-pancreas perfusion examination using a 256-slice CT. METHODS: 76 patients with known or suspected pancreatic mass underwent whole-pancreas perfusion by a 256-slice CT. High- and low-tube-voltage CT images were acquired. 120-kVp image data (protocol A and 80-kVp image data (protocol B were reconstructed with conventional FBP, and 80-kVp image data were reconstructed with iDose(4 (protocol C iterative reconstruction. The image noise; contrast-to-noise ratio (CNR relative to muscle for the pancreas, liver, and aorta; and radiation dose of each protocol were assessed quantitatively. Overall image quality was assessed qualitatively. Among 76 patients, 23 were eventually proven to have a normal pancreas. Perfusion parameters of normal pancreas in each protocol including blood volume, blood flow, and permeability-surface area product were measured. RESULTS: In the quantitative study, protocol C reduced image noise by 36.8% compared to protocol B (P<0.001. Protocol C yielded significantly higher CNR relative to muscle for the aorta, pancreas and liver compared to protocol B (P<0.001, and offered no significant difference compared to protocol A. In the qualitative study, protocols C and A gained similar scores and protocol B gained the lowest score for overall image quality (P<0.001. Mean effective doses were 23.37 mSv for protocol A and 10.81 mSv for protocols B and C. There were no significant differences in the normal pancreas perfusion values among three different protocols. CONCLUSION: Low-tube-voltage and iDose(4 iterative reconstruction can dramatically decrease the radiation dose with acceptable image quality during whole-pancreas CT perfusion and have no

  19. Evaluation of image quality and radiation dose at prospective ECG-triggered axial 256-slice multi-detector CT in infants with congenital heart disease

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Mei-ping; Liang, Chang-hong; Zhao, Zhen-jun; Liu, Hui; Li, Jing-lei; Zhang, Jin-e; Cui, Yan-hai; Yang, Lin; Liu, Qi-shun [Guangdong Academy of Medical Sciences, Guangdong General Hospital, Department of Radiology, Guangzhou (China); Ivanc, Thomas B.; Vembar, Mani [Philips Healthcare, CT Clinical Science, Highland Heights, OH (United States)

    2011-07-15

    There are a limited number of reports on the technical and clinical feasibility of prospective electrocardiogram (ECG)-gated multi-detector computed tomography (MDCT) in infants with congenital heart disease (CHD). To evaluate image quality and radiation dose at weight-based low-dose prospectively gated 256-slice MDCT angiography in infants with CHD. From November 2009 to February 2010, 64 consecutive infants with CHD referred for pre-operative or post-operative CT were included. All were scanned on a 256-slice MDCT system utilizing a low-dose protocol (80 kVp and 60-120 mAs depending on weight: 60 mAs for {<=}3 kg, 80 mAs for 3.1-6 kg, 100 mAs for 6.1-10 kg, 120 mAs for 10.1-15 kg). No serious adverse events were recorded. A total of 174 cardiac deformities, confirmed by surgery or heart catheterization, were studied. The sensitivity of MDCT for cardiac deformities was 97.1%; specificity, 99.4%; accuracy, 95.9%. The mean heart rate during scan was 136.7 {+-} 14.9/min (range, 91-160) with a corresponding heart rate variability of 2.8 {+-} 2.2/min (range, 0-8). Mean scan length was 115.3 {+-} 11.7 mm (range, 93.6-143.3). Mean volume CT dose index, mean dose-length product and effective dose were 2.1 {+-} 0.4 mGy (range, 1.5-2.8), 24.7 {+-} 5.9 mGy.cm (range, 14.7-35.8) and 1.6 {+-} 0.3 mSv (range, 1.1-2.5), respectively. Diagnostic-quality images were achieved in all cases. Satisfactory diagnostic quality for visualization of all/proximal/distal coronary artery segments was achieved in 88.4/98.8/80.0% of the scans. Low-dose prospectively gated axial 256-slice CT angiography is a valuable tool in the routine clinical evaluation of infants with CHD, providing a comprehensive three-dimensional evaluation of the cardiac anatomy, including the coronary arteries. (orig.)

  20. Tumor growth reduction is regulated at the gene level in Walker 256 tumor-bearing rats supplemented with fish oil rich in EPA and DHA.

    Science.gov (United States)

    Borghetti, G; Yamazaki, R K; Coelho, I; Pequito, D C T; Schiessel, D L; Kryczyk, M; Mamus, R; Naliwaiko, K; Fernandes, L C

    2013-08-01

    We investigated the effect of fish oil (FO) supplementation on tumor growth, cyclooxygenase 2 (COX-2), peroxisome proliferator-activated receptor gamma (PPARγ), and RelA gene and protein expression in Walker 256 tumor-bearing rats. Male Wistar rats (70 days old) were fed with regular chow (group W) or chow supplemented with 1 g/kg body weight FO daily (group WFO) until they reached 100 days of age. Both groups were then inoculated with a suspension of Walker 256 ascitic tumor cells (3 × 10(7) cells/mL). After 14 days the rats were killed, total RNA was isolated from the tumor tissue, and relative mRNA expression was measured using the 2(-ΔΔCT) method. FO significantly decreased tumor growth (W=13.18 ± 1.58 vs WFO=5.40 ± 0.88 g, Psupplementation also resulted in a significant decrease in COX-2 (W=100.1 ± 1.62 vs WFO=59.39 ± 5.53, Pprotein expression. Relative mRNA expression was W=1.06 ± 0.022 vs WFO=0.31 ± 0.04 (P<0.001) for COX-2, W=1.08 ± 0.02 vs WFO=0.52 ± 0.08 (P<0.001) for PPARγ, and W=1.04 ± 0.02 vs WFO=0.82 ± 0.04 (P<0.05) for RelA. FO reduced tumor growth by attenuating inflammatory gene expression associated with carcinogenesis.

  1. Tumor growth reduction is regulated at the gene level in Walker 256 tumor-bearing rats supplemented with fish oil rich in EPA and DHA

    Energy Technology Data Exchange (ETDEWEB)

    Borghetti, G.; Yamazaki, R.K.; Coelho, I.; Pequito, D.C.T.; Schiessel, D.L.; Kryczyk, M.; Mamus, R.; Naliwaiko, K.; Fernandes, L.C. [Departamento de Fisiologia, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba, PR (Brazil)

    2013-08-23

    We investigated the effect of fish oil (FO) supplementation on tumor growth, cyclooxygenase 2 (COX-2), peroxisome proliferator-activated receptor gamma (PPARγ), and RelA gene and protein expression in Walker 256 tumor-bearing rats. Male Wistar rats (70 days old) were fed with regular chow (group W) or chow supplemented with 1 g/kg body weight FO daily (group WFO) until they reached 100 days of age. Both groups were then inoculated with a suspension of Walker 256 ascitic tumor cells (3×10{sup 7} cells/mL). After 14 days the rats were killed, total RNA was isolated from the tumor tissue, and relative mRNA expression was measured using the 2{sup -ΔΔCT} method. FO significantly decreased tumor growth (W=13.18±1.58 vs WFO=5.40±0.88 g, P<0.05). FO supplementation also resulted in a significant decrease in COX-2 (W=100.1±1.62 vs WFO=59.39±5.53, P<0.001) and PPARγ (W=100.4±1.04 vs WFO=88.22±1.46, P<0.05) protein expression. Relative mRNA expression was W=1.06±0.022 vs WFO=0.31±0.04 (P<0.001) for COX-2, W=1.08±0.02 vs WFO=0.52±0.08 (P<0.001) for PPARγ, and W=1.04±0.02 vs WFO=0.82±0.04 (P<0.05) for RelA. FO reduced tumor growth by attenuating inflammatory gene expression associated with carcinogenesis.

  2. Discussion of “Geomechanical modeling of the nucleation process of Australia's 1989 M5.6 Newcastle earthquake” by C.D. Klose [Earth Planet. Sci. Lett. 256 (2007) 547 553

    Science.gov (United States)

    Quinn, C. D.; Glen, R. A.; Diessel, C. F. K.

    2008-05-01

    On the basis of a numerical simulation, Klose [Earth Planet. Sci. Lett. 256: 547-553 (2007)] proposed that the MW = 5.2-5.6 earthquake that nucleated beneath Newcastle (New South Wales, Australia) at 10.30 AM December 28, 1989 (AEST), was the result of 200yr of coal mining in the region. We argue here that Klose's [Earth Planet. Sci. Lett. 256: 547-553 (2007)] ultimate conclusion is not supported by his own model or by available geological and seismic data. In particular, the 1989 Newcastle earthquake was not anomalous with respect to regional seismic activity.

  3. 256层螺旋CT对颈动脉狭窄程度与性别及年龄关系的初步研究%A preliminary study in the relationship carotid stenosis and age or gender by 256 -slice carotid ;CTA

    Institute of Scientific and Technical Information of China (English)

    乔桂荣; 杨海庆; 李彩英; 刘晓伟; 宋登浩; 尹兰英

    2016-01-01

    Objective To quantitatively analyze the relationship between carotid stenosis and gender or age by 256 -slice carotid CTA .Method A retrospective analysis of 573 cases image data of 256 iCT carotid angiography, male 332 cases, female 241 cases, with an average age of 57.22 ± 13.02 years old. Multi- planar reconstruction (MPR), maximum density image (MIP), volume rendering (VR) technology were used in post-processing workstations, carotid artery , internal carotid artery atherosclerotic plaque location and degree of stenosis were measured. Results Men were more likely than women with mild stenosis . However, there was no difference between males and females in internal carotid artery(P = 0.027) . Males were more often than females either in carotid arteries or in internal carotid artery with moderate or severe (P = 0.013, P = 0.000) . There were correlated among carotid artery stenosis degree with different age group(P = 0.000), with age increases the degree of stenosis increased.Conclusion 256 iCTA can be objectively display carotid artery stenosis degree and plaque, gender and age are very important factors of carotid stenosis .%目的:采用256iCT血管造影对颈动脉狭窄定量分析,探讨颈动脉狭窄程度与性别及年龄的关系。方法分析于本院接受256iCT颈动脉造影检查患者的影像资料573例,男性332例,女性241例,平均年龄57.22±13.02岁。采用多平面重建(MPR)、最大密度图像(MIP)、容积再现(VR)等技术分别测量及统计颈总动脉、颈内动脉动脉粥样硬化斑块部位及狭窄程度。结果颈总动脉轻度狭窄有性别分布差异,男性轻度狭窄者较女性多(P=0.027);颈内动脉轻度狭窄无性别分布差异;颈总动脉及颈内动脉中度及以上狭窄均有性别分布差异(P=0.013,P=0.000),男性中度以上狭窄者较女性多;颈总动脉及颈内动脉动脉狭窄程度与年龄均有相关性(P=0.000),随年龄增加

  4. THE 256 CTA IMAGING CHARACTERISTICS AND THE RELATED RISK FACTORS IN PATIENTS WITH TYPE 2 DIABETIC LOWER EXTREMITY VASCULAR DISEASE%2型糖尿病下肢血管病变256层CTA成像特点及危险因素分析

    Institute of Scientific and Technical Information of China (English)

    柳治; 周静; 薛连彬; 杨冬生

    2016-01-01

    目的 探讨糖尿病下肢血管病变(Lower extremity arterial disease,LEAD)患者下肢血管256层螺旋CT血管造影(CT angiography,CTA)成像特点及发生危险因素.方法 回顾性分析2型糖尿病150例的临床及下肢动脉256层CTA资料,分析糖尿病LEAD病变特点,比较LEAD与非LEAD一般资料差异,并对糖尿病LEAD相关危险因素进行Logistic回归分析.结果 256层CTA诊断LEAD 112例,动脉狭窄程度Ⅰ级26例,Ⅱ级33例,Ⅲ级40例,Ⅳ级13例;狭窄节段血管1 156支,发生在髂总动脉89支,髂外动脉94支,髂内动脉85支,股总动脉76支,股浅动脉89支,股深动脉57支,腘动脉129支,胫前动脉165支,胫腓干77支,胫后动脉152支,腓动脉143支.LEAD组和非LEAD组性别、病程、收缩压(SBP)、舒张压(DBP)、餐后2h血糖(PBG2h)、糖化血红蛋白(HbA1C)、C反应蛋白(CRP)、低密度脂蛋白胆固醇(LDL-C)及同型半胱氨酸(Hey)比较差异有统计学意义(P<0.05).Logistic回归分析结果显示,HbA1C、SBP、CRP、Hcy及LDL-C与2型糖尿病LEAD明显相关.结论 256层CTA是一种简便、安全、准确的早期检出糖尿病LEAD的手段,糖尿病患者应综合管理血糖、血压、血脂等多种危险因素,以预防和延缓LEAD发生、发展.%Objective To study the 256 slice CT angiography (256-CTA) imaging characteristics in patierts with diabetic lower extremity vascular disease and its risk factors Methods A retrospective analysis on the 256-CTA imaging data of 130 type 2 diabetes with lower extremity arterial was performed.The DLEAD characteristics were analyzed,and clinical data were compared between the LEAD group and no LEAD group,the relative risk factors were analyzed by the logistic regression.Results The 256-CTA could early diagnosis DLEAD and visually evaluate the severity,and 112 cases were diagnosed.Grade I stenosis degree of carotid artery was 26 cases,grade Ⅱ in 33,grade Ⅲ in 40,and grade Ⅳ in 13.Narrow segmental blood vessels were 1156

  5. Two novel variants of human medium chain acyl-CoA dehydrogenase (MCAD). K364R, a folding mutation, and R256T, a catalytic-site mutation resulting in a well-folded but totally inactive protein

    DEFF Research Database (Denmark)

    O'Reilly, Linda P; Andresen, Brage S; Engel, Paul C

    2005-01-01

    Two novel rare mutations, MCAD approximately 842G-->C (R256T) and MCAD approximately 1166A-->G (K364R), have been investigated to assess how far the biochemical properties of the mutant proteins correlate with the clinical phenotype of medium chain acyl-CoA dehydrogenase (MCAD) deficiency. When t...

  6. Feasibility of establishment of rat model of bone cancer pain by using Walker 256 cells cultured in vitro or in vivo%腹水传代与体外培养Walker 256癌细胞系建立大鼠骨癌痛模型的可行性

    Institute of Scientific and Technical Information of China (English)

    姚明; 杨建平; 王丽娜; 成浩; 张艳兵; 许期年; 吴翼伟

    2008-01-01

    目的 探讨腹水传代与体外培养Walker 256细胞接种建立SD大鼠骨癌痛模型的可行性并验证其可靠性.方法 体外培养细胞与大鼠腹水传代培养Walker 256细胞,种植于SD大鼠左胫骨上端.大鼠分为Hank's液对照组(N组)、热杀死肿瘤细胞组(K组)、体外培养的肿瘤细胞种植组(V组)和腹水肿瘤细胞种植组(A组),每组8只.通过疼痛行为学、镇痛药效学、影像学、病理组织学等检查评估肿瘤及疼痛发生发展情况.结果 大鼠接种后肛温无明显变化.A组与V组大鼠术后第6天开始左侧后肢活动度开始下降,X线摄片可见左胫骨上端骨小梁小缺损;第12天X线摄片示骨皮质有破坏,放射性核素显像可见接种区反应性骨形成活跃;第14天增重开始减缓;第18天X线摄片显示大片骨质缺损,软组织肿块形成,左胫骨病理切片示骨癌细胞生长.模型大鼠接种后第6~18天,机械性压爪缩爪阈值、触痛觉超敏von Frey阈值、左侧后肢负重进行性下降(P<0.01).术后第15天注射吗啡后,模型大鼠机械性压爪缩爪阈值呈剂量依赖性增高,而纳洛酮可拮抗此效应.结论 经腹水传代与体外培养Walker 256细胞均可用于SD大鼠骨癌痛模型的建立;经腹水传代建模更为简便.%Objective To investigate the possibility of establishing rat model of bone cancer pain using cancer cells cultured in vitro or by ascites passaging and verify the reliability of this method.Methods Syngeneic SD rat carcinoma cells of the line Walker 256 were cultured in vitro and inoculated into the peritoneal cavity of SD rats respectively.Two kinds of Walker 256 cell suspension were made.Thirty-two SD rats were randomly divided into 4 equal groups:Group N(undergoing injection of Hank's solution into cavitas medullaris of left tibia),Group K(undergoing injection of heat-killed Walker 256 cells),Group V (injected with Walker 256 cells cultured in vitro),and Group A(injected with Walker

  7. Alterations caused by physical training in pulmonary edema and loss of muscle mass in rats with Walker-256 tumor Alterações promovidas pelo treinamento físico no edema pulmonar e perda de massa muscular em ratos portadores de tumor Walker-256

    Directory of Open Access Journals (Sweden)

    Rubens Cecchini

    2008-10-01

    Full Text Available Walker-256 tumor is a fast-growing tumor and has been studied under several metabolic aspects associated or not to cachexia. It was observed in our laboratory that animals with Walker-256 tumor, after spontaneous death (usually around the fifteenth day, showed significant pulmonary edema with fluid in the pleural cavity. Some studies have suggested that physical training improves the survival of animals with tumor and minimizes the effects of cachexia. The purpose of our work was to assess the pulmonary edema index as well as the cardiac and skeletal muscle mass, besides the survival of rats with Walker-256 tumor submitted previously to physical training through swimming (N. For this study male Wistar rats (200 to 220 g were used, submitted to physical training through swimming (1 hour; 5 days a week, four weeks. One day after the training, sedentary rats (C or trained ones (N were submitted to inoculation on the right flank of 8 x 107 Walker-256 tumor cells (T. Immediately after spontaneous death of these animals, the pulmonary edema index (PEI, cardiac and skeletal muscle mass (gastrocnemius and soleus were evaluated. Pulmonary edema was evaluated through the index calculated by the relation between lung and body weights of each animal, and multiplied by 100 (PP/PC x 100 (LEE et al., 2001. Muscle mass (MM index was calculated similarly. In normal animals the PEI is equal to 0,53±0,02 (n=20. In tumor-bearing rats after spontaneous death the PEI was significantly higher (2,62±0,31, n=18. After the physical training in rats without tumor, the PEI was 0,55±0,03 (n=5. Whereas in tumor-bearing rats previously trained, it was obtained a pulmonary edema index lower than that of the control group with tumor (1,46±0,16, n=5; pO tumor Walker-256 é um carcinoma de crescimento rápido e tem sido estudado sob vários aspectos metabólicos, associados ou não, à caquexia. Foi observado, em nosso laboratório, que em animais portadores de tumor Walker

  8. Paired observation of californium-252 neutron intraluminal brachytherapy combined with external-beam radiotherapy with and without lead shielding for cervical cancer%252 Cf中子腔内照射结合挡铅与不挡铅外照射治疗宫颈癌的配对观察

    Institute of Scientific and Technical Information of China (English)

    戴卓捷; 雷新; 陈永红; 刘佳

    2015-01-01

    目的:比较252 Cf中子腔内照射结合挡铅盆腔对穿野和不挡铅箱式四野外照射治疗宫颈癌的治疗结果。方法2004—2007年本院收治的Ⅱa—Ⅲb 期的宫颈鳞癌患者,按照临床分期、年龄、肿瘤大小、贫血程度为配对条件,共筛选出26对(52例)研究对象,分为挡铅盆腔对穿野组(挡铅组)和不挡铅箱式四野组(不挡铅组)。两组患者外照射期间穿插252 Cf中子后装治疗。 Kaplan?Meier法计算5年LC、OS、DFS 并 Logrank 检验差异,晚期并发症发生率差异行 McNemar 法检验。结果挡铅、不挡铅组5年LC 率分别为85%、81%(P=0??014),OS 率分别为89%、73%(P=0??013),DFS 率分别为89%、73%(P=0??013),晚期并发症发生率分别为12%、23%(P=0??008)。结论腔内照射结合外照射治疗宫颈癌时无论采取对穿野还是箱式四野,后程前后野中央均应挡铅。%Objective To compare the efficacy between californium?252 ( 252 Cf ) neutron intraluminal brachytherapy combined with external?beam radiotherapy with lead?shielding pelvic parallel opposing field technique and non?lead?shielding four?field box technique for cervical cancer. Methods A total of 52 patients with stage Ⅱa?Ⅲb cervical squamous cell carcinoma who were admitted to our hospital from 2004 to 2007 were enrolled as subjects and paired by clinical stage, age, tumor size, and degree of anemia. The 26 pairs of patients were divided into lead?shielding pelvic parallel opposing field group (lead?shielding group) and non?lead?shielding four?field box group (non?lead?shielding group). For all patients in both groups, 252 Cf neutron brachytherapy was added in external?beam radiotherapy. The local control (LC), overall survival (OS), and disease?free survival (DFS) rates were calculated using the Kaplan?Meier method and analyzed using the log?rank test. The difference in the incidence of late complications was

  9. Infections During Induction Therapy of Protocol CCLG-2008 in Childhood Acute Lymphoblastic Leukemia: A Single-center Experience with 256 Cases in China

    Institute of Scientific and Technical Information of China (English)

    Si-Dan Li; Yong-Bing Chen; Zhi-Gang Li; Run-Hui Wu; Mao-Quan Qin; Xuan Zhou; Jin Jiang

    2015-01-01

    Background:Infections remain a major cause of therapy-associated morbidity and mortality in children with acute lymphoblastic leukemia (ALL).Methods:We retrospectively analyzed the medical charts of 256 children treated for ALL under the CCLG-2008 protocol in Beijing Children's Hospital.Results:There were 65 infectious complications in 50 patients during vincristine,daunorubicin,L-asparaginase and dexamethasone induction therapy,including microbiologically documented infections (n =12; 18.5%),clinically documented infections (n =23; 35.3%) and fever of unknown origin (n =30; 46.2%).Neutropenia was present in 83.1% of the infectious episodes.In all,most infections occurred around the 15t1h day of induction treatment (n =28),and no patients died of infection-associated complications.Conclusions:The infections in this study was independent of treatment response,minimal residual diseases at the end of induction therapy,gender,immunophenotype,infection at first visit,risk stratification at diagnosis,unfavorable karyotypes at diagnosis and morphologic type.The infection rate of CCLG-2008 induction therapy is low,and the outcome of patients is favorable.

  10. Study of EDFA and Raman system transmission reach with 256 Gb/s PM-16QAM signals over three optical fibers with 100 km spans.

    Science.gov (United States)

    Downie, John D; Hurley, Jason; Pikula, Dragan; Ten, Sergey; Towery, Chris

    2013-07-15

    We compare the transmission performance of three different optical fibers in separate 256 Gb/s PM-16QAM systems amplified with erbium doped fiber amplifiers (EDFAs) and distributed Raman amplification. The span length in each system is 100 km. The fibers studied include standard single-mode fiber, single-mode fiber with ultra-low loss, and ultra-low loss fiber with large effective area. We find that the single-mode fiber with ultra-low loss and the large effective area fiber with ultra-low loss afford reach advantages of up to about 31% and 80%, respectively, over standard fiber measured at distances with 3 dB margin over the forward error correction (FEC) threshold. The Raman amplified systems provide about 50% reach length enhancement over the EDFA systems for all three fibers in the experimental set-up. For the best performing fiber with large effective area and ultra-low loss, the absolute reach lengths with 3 dB margin are greater than 1140 km and 1700 km for the for EDFA and Raman systems, respectively.

  11. Design and characterization of a 256 x 64-pixel single-photon imager in CMOS for a MEMS-based laser scanning time-of-flight sensor.

    Science.gov (United States)

    Niclass, Cristiano; Ito, Kota; Soga, Mineki; Matsubara, Hiroyuki; Aoyagi, Isao; Kato, Satoru; Kagami, Manabu

    2012-05-21

    We introduce an optical time-of-flight image sensor taking advantage of a MEMS-based laser scanning device. Unlike previous approaches, our concept benefits from the high timing resolution and the digital signal flexibility of single-photon pixels in CMOS to allow for a nearly ideal cooperation between the image sensor and the scanning device. This technique enables a high signal-to-background light ratio to be obtained, while simultaneously relaxing the constraint on size of the MEMS mirror. These conditions are critical for devising practical and low-cost depth sensors intended to operate in uncontrolled environments, such as outdoors. A proof-of-concept prototype capable of operating in real-time was implemented. This paper focuses on the design and characterization of a 256 x 64-pixel image sensor, which also comprises an event-driven readout circuit, an array of 64 row-level high-throughput time-to-digital converters, and a 16 Gbit/s global readout circuit. Quantitative evaluation of the sensor under 2 klux of background light revealed a repeatability error of 13.5 cm throughout the distance range of 20 meters.

  12. Coronary Plaque Characteristics Assessed by 256-Slice Coronary CT Angiography and Association with High-Sensitivity C-Reactive Protein in Symptomatic Patients with Type 2 Diabetes

    Directory of Open Access Journals (Sweden)

    Jinling Zhang

    2016-01-01

    Full Text Available Little is known regarding plaque distribution, composition, and the association with inflammation in type 2 diabetes mellitus (DM2. This study aimed to assess the relationship between coronary plaque subtypes and high-sensitivity C-reactive protein levels. Coronary CTA were performed in 98 symptomatic DM2 patients and 107 non-DM2 patients using a 256-slice CT. The extent and types of plaque as well as luminal narrowing were evaluated. Patients with DM2 were more likely to have significant stenosis (>50% with calcified plaques in at least one coronary segment (p<0.01; the prevalence rates of diffuse calcified plaques in the DM2 and non-DM2 groups were 31.6% and 4.7%, respectively (p<0.01. Plasma hs-CRP levels in DM2 with calcified plaques were higher compared with values obtained for the non-DM2 group (p<0.01. In conclusion, combination of coronary CTA and hs-CRP might improve risk stratification in symptomatic DM2 patients.

  13. Characterisation of clinical meticillin-resistant Staphylococcus epidermidis demonstrating high levels of linezolid resistance (>256 μg/ml) resulting from transmissible and mutational mechanisms.

    Science.gov (United States)

    Gabriel, Emma M; Fitzgibbon, Siobhan; Clair, James; Coffey, Aidan; O'Mahony, Jim M

    2015-07-01

    Staphylococcus epidermidis (S. epidermidis), one of the leading etiological agents of nosocomial infections poses a significant economic burden globally. Introduced in 2000, linezolid (LZD) has become an important antibiotic, used in nearly seventy countries worldwide to treat infections caused by Gram-positive pathogens such as meticillin-resistant Staphylococcus and Streptococcus species along with vancomycin-resistant enterococci. Resistance to LZD in clinical settings remains rare. Here, we report the emergence of meticillin resistant S. epidermidis (MRSE) clinical isolates from two voluntary general acute hospitals exhibiting higher than typically reported levels of LZD resistance (MIC>256 μg/ml). The MRSE ST-2 clone isolated from eight patients (2010-2011) not only possessed resistance-conferring mutations such as G2576T in domain V of 23S rRNA gene (as determined by HRM-PCR analysis) and R172C substitution in the ribosomal protein L3, but also carried the cfr gene (the only known transmissible mechanism of LZD resistance). All isolates possessed several key biofilm-associated genes (such as icaA, icaD, aap and atlE) and resistance to multiple clinically significant antibiotics was recorded. This study reports the earliest incidence (2010) of clinical MRSE in the Republic of Ireland demonstrating multiple LZD resistance mechanisms both mutational and potentially transmissible, and characterises this emerging resistance from a molecular perspective.

  14. Flexible non-volatile optical memory thin-film transistor device with over 256 distinct levels based on an organic bicomponent blend

    Science.gov (United States)

    Leydecker, Tim; Herder, Martin; Pavlica, Egon; Bratina, Gvido; Hecht, Stefan; Orgiu, Emanuele; Samorì, Paolo

    2016-09-01

    Organic nanomaterials are attracting a great deal of interest for use in flexible electronic applications such as logic circuits, displays and solar cells. These technologies have already demonstrated good performances, but flexible organic memories are yet to deliver on all their promise in terms of volatility, operational voltage, write/erase speed, as well as the number of distinct attainable levels. Here, we report a multilevel non-volatile flexible optical memory thin-film transistor based on a blend of a reference polymer semiconductor, namely poly(3-hexylthiophene), and a photochromic diarylethene, switched with ultraviolet and green light irradiation. A three-terminal device featuring over 256 (8 bit storage) distinct current levels was fabricated, the memory states of which could be switched with 3 ns laser pulses. We also report robustness over 70 write-erase cycles and non-volatility exceeding 500 days. The device was implemented on a flexible polyethylene terephthalate substrate, validating the concept for integration into wearable electronics and smart nanodevices.

  15. Decreased response to cAMP in the glucose and glycogen catabolism in perfused livers of Walker-256 tumor-bearing rats.

    Science.gov (United States)

    de Morais, Hely; Cassola, Priscila; Moreira, Carolina Campos Lima; Bôas, Suéllen Kathiane Fernandes Vilas; Borba-Murad, Glaucia Regina; Bazotte, Roberto Barbosa; de Souza, Helenir Medri

    2012-09-01

    The hepatic response to cyclic adenosine monophosphate (cAMP) and N6-monobutyryl-cAMP (N6-MB-cAMP) in the glucose and glycogen catabolism and hepatic glycogen levels were evaluated in Walker-256 tumor-bearing rats, on days 5 (WK5), 8 (WK8), and 11 (WK11) after the implantation of tumor. Rats without tumor fed ad libitum (fed control rats) or that received the same daily amount of food ingested by anorexics tumor-bearing rats (pair-fed control rats) or 24 h fasted (fasted control rats) were used as controls. Glucose and glycogen catabolism were measured in perfused liver. Hepatic glycogen levels were lower (p catabolism was lower (p catabolism, under condition of depletion of hepatic glycogen (24 h fast), was lower (p catabolism was lower (p catabolism in various stages of tumor development (days 5, 8 and 11), which was probably not due to the lower hepatic glycogen levels nor due to the increased activity of PDE3B.

  16. 256层ICT探测冠状动脉钙化在不稳定心绞痛与稳定心绞痛患者中的对比%Detection of Coronary Artery Calcification Score and Compare it in Patients Diagnosed Clinically as Stable and Unstable Angina by 256 ICT

    Institute of Scientific and Technical Information of China (English)

    朱大光

    2013-01-01

    目的:探讨256层ICT在探测冠状动脉钙化积分中的意义。方法:采用256层ICT对2组患者进行冠状动脉钙化积分扫描,钙化积分由工作站软件自动获得,132例患者分为2组,55例稳定心绞痛,77不例稳定心绞痛。结果:不稳定心绞痛患者的钙化积分要显著大于稳定心绞痛患者(p<0.05),不稳定心绞痛患者的血管钙化数目要明显多于稳定心绞痛组。结论:不稳定心绞痛患者的钙化更明显,因此预测冠状动脉情况冠状动脉钙化积分可以作为重要指标。%Objective:To detect Coronary calcification score and compare it in patients diagnosed clinically of having stable and unsta -ble angina and they being more prone for cardiovascular risk .Methods:Coronary artery calcification was scanned and its scores ( CACS) were measured through 256-slice ICT in 132 patients diagnosed of having stable and unstable angina .(55 stable and 77 unstable angi-na).the result were analyzed statistically by 2-grouped test.Also some associated risk factors were also taken into concideraton (HTN, total cholesterol ,Triglycerides etc ) .Results:The calcification scores in patients with unstable angina were comparatively more than those with patients having stable angina (p<0.05).Also it found that 3-vesssel calcification was more significant with unstable angina ,where as 1-vesssel calcification was more significant with stable angina cases .Conclusion:Coronary artery calcification scores is of great value in predicting cardiovascular enets .

  17. 个体化对比剂注射方案在256层CT冠状动脉成像中的应用%Application of the individual protocol of contrast medium injection in coronary angiography by 256-slice CT

    Institute of Scientific and Technical Information of China (English)

    曹希明; 黄美萍; 郑君惠; 巫梓斌; 温孟皇

    2012-01-01

    目的 探讨个体化对比剂注射方案在256层CT冠状动脉成像中的应用价值.方法 100例临床怀疑冠心病需接受冠状动脉CT(CTA)检查者,按照对比剂注射方案个体化原则,对比剂总量(ml)=患者体重(kg),对比剂流率ml/s=对比剂总量/(扫描时间+8)ml/s,同样流率追加30ml生理盐水}进行冠脉CTA检查,测量升主动脉根部左冠开口处CT值并对冠状动脉的显示进行评分,分析对比剂注射方案个体化的可行性.结果 按照个体化对比剂注射方案行冠脉CTA检查后,100例检查者升主动脉根部左冠开口处平均强化程度为(420.19±56.59) HU,冠状动脉显示评分得3分比例为88.78%,得2分比例为11.22%,无得1分者.结论 个体化对比剂注射方案在256层CT冠状动脉成像中具有良好的应用价值.%Objective To investigate the application value of individual protocol of contrast medium injection in coronary angiography by 256-slice CT. Methods 100 subjects with clinically suspected coronary disease underwent coronary artery CT inspection, according to the individual principle of contrast agent injection plan, that is, total amount of contrast agent (ml) equals to patients body weight (kg), discharge rate of contrast agent (ml/s) equals to total amount of contrast agent /(trace time +8) ml/s, and 30 ml physiological saline is supplemented if the discharge rate is similar. Subsequently, the CT value of left crown jaw opening in ascending aorta root was measured and the coronary artery's demonstration was graded so as to analyze the feasibility of individual plan of contrast agent injection. Results After the CTA inspection via the individuation of contrast agent injection plan, the mean strengthening degree of left crown jaw opening in ascending aorta root of these 100 patients was (420. 19±56. 59) HU. The coronary artery demonstrated scale was 3 in 88. 78%, 2 in 11. 22%, and 1 in none. Conclusion Individuation of contrast media injection protocol

  18. Inhibitory Effects of 99 Tc-MDP Injection on Bone Invasion by Walker256 Carcinoma in Rats%99锝亚甲基二膦酸盐对Walker256癌荷瘤大鼠骨侵袭的抑制作用

    Institute of Scientific and Technical Information of China (English)

    陈英茂; 张锦明; 田嘉禾; 姚树林; 丁为民

    2003-01-01

    目的:研究99锝亚甲基二膦酸盐(99Tc-MDP)注射液对大鼠骨侵袭的抑制作用.方法:建立Walker256癌荷瘤大鼠模型.分空白对照组、骨膦对照组及99Tc-MDP 8,4,2,1 mg 4个剂量组.腹腔内注射药物10 d后,处死大鼠取瘤组织称重,剥离左、右腿胫骨称重,摄胫骨X线片,作组织切片.结果:与对照组比较:99Tc-MDP 8和4 mg组及骨膦对照组对减轻荷瘤侧胫骨增重及骨侵袭程度均差异有显著性(P<0.05);99Tc-MDP 8和4 mg组与骨膦对照组相比差异无显著性(P>0.05);99Tc-MDP 2和1 mg组对癌细胞骨侵袭的抑制作用均差异无显著性(P>0.05).结论:99Tc-MDP及骨膦注射液对Walker256癌荷瘤大鼠均有抑制癌细胞骨侵袭的作用;在抑制程度上,骨膦注射液与99Tc-MDP作用相当;99Tc-MDP 4个剂量组的抑制程度与剂量呈正相关.

  19. The hemolytic component of cancer anemia: effects of osmotic and metabolic stress on the erythrocytes of rats bearing multifocal inoculations of the Walker 256 tumor

    Directory of Open Access Journals (Sweden)

    Vido A.A.

    2000-01-01

    Full Text Available Cancer anemia is classified as an anemia of chronic diseases, although it is sometimes the first symptom of cancer. Cancer anemia includes a hemolytic component, important in the terminal stage when even transfused cells are rapidly destroyed. The presence of a chronic component and the terminal complications of the illness limit studies of the hemolytic component. A multifocal model of tumor growth was used here to simulate the terminal metastatic dissemination stage (several simultaneous inoculations of Walker 256 cells. The hemolytic component of anemia began 3-4 days after inoculation in 100% of the rats and progressed rapidly thereafter: Hb levels dropped from 14.9 ± 0.02 to 8.7 ± 0.06 from days 7 to 11 (~5 times the physiologically normal rate in rats in the absence of bleeding. The development of anemia was correlated (r2 = 0.86 with the development of other systemic effects such as anorexia. There was a significant decrease in the osmotic fragility of circulating erythrocytes: the NaCl concentration causing 50% lysis was reduced from 4.52 ± 0.06 to 4.10 ± 0.01 (P<0.01 on day 7, indicating a reduction in erythrocyte volume. However, with mild metabolic stress (4-h incubation at 37oC, the erythrocytes showed a greater increase in osmotic fragility than the controls, suggesting marked alteration of erythrocyte homeostasis. These effects may be due to primary plasma membrane alterations (transport and/or permeability and/or may be secondary to metabolic changes. This multifocal model is adequate for studying the hemolytic component of cancer anemia since it is rapid, highly reproducible and causes minimal animal suffering.

  20. Changes in red blood cell osmotic fragility induced by total plasma and plasma fractions obtained from rats bearing progressive and regressive variants of the Walker 256 tumor

    Directory of Open Access Journals (Sweden)

    Cavalcanti T.C.

    2003-01-01

    Full Text Available Two variants (A and B of the widely employed Walker 256 rat tumor cells are known. When inoculated sc, the A variant produces solid, invasive, highly metastasizing tumors that cause severe systemic effects and death. We have obtained a regressive variant (AR whose sc growth is slower, resulting in 70-80% regression followed by development of immunity against A and AR variants. Simultaneously with the beginning of tumor regression, a temporary anemia developed (~8 days duration, accompanied by marked splenomegaly (~300% and changes in red blood cell osmotic fragility, with mean corpuscular fragility increasing from 4.1 to 6.5 g/l NaCl. The possibility was raised that plasma factors associated with the immune response induced these changes. In the present study, we identify and compare the osmotic fragility increasing activity of plasma fractions obtained from A and AR tumor bearers at different stages of tumor development. The results showed that by day 4 compounds precipitating in 60% (NH42SO4 and able to increase red blood cell osmotic fragility appeared in the plasma of A and AR tumor bearers. Later, these compounds disappeared from the plasma of A tumor bearers but slightly increased in the plasma of AR tumor bearers. Furthermore, by day 10, compounds precipitating between 60 and 80% (NH42SO4 and with similar effects appeared only in plasma of AR tumor bearers. The salt solubility, production kinetics and hemolytic activity of these compounds resemble those of the immunoglobulins. This, together with their preferential increase in rats bearing the AR variant, suggest their association with an immune response against this tumor.

  1. Uncaria tomentosa exerts extensive anti-neoplastic effects against the Walker-256 tumour by modulating oxidative stress and not by alkaloid activity.

    Science.gov (United States)

    Dreifuss, Arturo Alejandro; Bastos-Pereira, Amanda Leite; Fabossi, Isabella Aviles; Lívero, Francislaine Aparecida Dos Reis; Stolf, Aline Maria; Alves de Souza, Carlos Eduardo; Gomes, Liana de Oliveira; Constantin, Rodrigo Polimeni; Furman, Aline Emmer Ferreira; Strapasson, Regiane Lauriano Batista; Teixeira, Simone; Zampronio, Aleksander Roberto; Muscará, Marcelo Nicolás; Stefanello, Maria Elida Alves; Acco, Alexandra

    2013-01-01

    This study aimed to compare the anti-neoplastic effects of an Uncaria tomentosa (UT) brute hydroethanolic (BHE) extract with those of two fractions derived from it. These fractions are choroformic (CHCl3) and n-butanolic (BuOH), rich in pentacyclic oxindole alkaloids (POA) and antioxidant substances, respectively. The cancer model was the subcutaneous inoculation of Walker-256 tumour cells in the pelvic limb of male Wistar rat. Subsequently to the inoculation, gavage with BHE extract (50 mg.kg(-1)) or its fractions (as per the yield of the fractioning process) or vehicle (Control) was performed during 14 days. Baseline values, corresponding to individuals without tumour or treatment with UT, were also included. After treatment, tumour volume and mass, plasma biochemistry, oxidative stress in liver and tumour, TNF-α level in liver and tumour homogenates, and survival rates were analysed. Both the BHE extract and its BuOH fraction successfully reduced tumour weight and volume, and modulated anti-oxidant systems. The hepatic TNF-α level indicated a greater effect from the BHE extract as compared to its BuOH fraction. Importantly, both the BHE extract and its BuOH fraction increased the survival time of the tumour-bearing animals. Inversely, the CHCl3 fraction was ineffective. These data represent an in vivo demonstration of the importance of the modulation of oxidative stress as part of the anti-neoplastic activity of UT, as well as constitute evidence of the lack of activity of isolated POAs in the primary tumour of this tumour lineage. These effects are possibly resulting from a synergic combination of substances, most of them with antioxidant properties.

  2. Uncaria tomentosa exerts extensive anti-neoplastic effects against the Walker-256 tumour by modulating oxidative stress and not by alkaloid activity.

    Directory of Open Access Journals (Sweden)

    Arturo Alejandro Dreifuss

    Full Text Available This study aimed to compare the anti-neoplastic effects of an Uncaria tomentosa (UT brute hydroethanolic (BHE extract with those of two fractions derived from it. These fractions are choroformic (CHCl3 and n-butanolic (BuOH, rich in pentacyclic oxindole alkaloids (POA and antioxidant substances, respectively. The cancer model was the subcutaneous inoculation of Walker-256 tumour cells in the pelvic limb of male Wistar rat. Subsequently to the inoculation, gavage with BHE extract (50 mg.kg(-1 or its fractions (as per the yield of the fractioning process or vehicle (Control was performed during 14 days. Baseline values, corresponding to individuals without tumour or treatment with UT, were also included. After treatment, tumour volume and mass, plasma biochemistry, oxidative stress in liver and tumour, TNF-α level in liver and tumour homogenates, and survival rates were analysed. Both the BHE extract and its BuOH fraction successfully reduced tumour weight and volume, and modulated anti-oxidant systems. The hepatic TNF-α level indicated a greater effect from the BHE extract as compared to its BuOH fraction. Importantly, both the BHE extract and its BuOH fraction increased the survival time of the tumour-bearing animals. Inversely, the CHCl3 fraction was ineffective. These data represent an in vivo demonstration of the importance of the modulation of oxidative stress as part of the anti-neoplastic activity of UT, as well as constitute evidence of the lack of activity of isolated POAs in the primary tumour of this tumour lineage. These effects are possibly resulting from a synergic combination of substances, most of them with antioxidant properties.

  3. Diagnostic accuracy of low-dose 256-slice multi-detector coronary CT angiography using iterative reconstruction in patients with suspected coronary artery disease

    Energy Technology Data Exchange (ETDEWEB)

    Hou, Yang; Ma, Yue; Wang, Yuke; Yu, Mei; Guo, Qiyong [Shengjing Hospital of China Medical University, Department of Radiology, Shenyang (China); Fan, Weipeng [Central Hospital of Anshan, Department of Radiology, Anshan (China); Vembar, Mani [CT Clinical Science Philips Healthcare, Cleveland, OH (United States)

    2014-01-15

    To evaluate the accuracy of low-dose coronary CTA with iterative reconstruction (IR) in the diagnosis of coronary artery disease (CAD) in patients with suspected CAD. Ninety-six patients with suspected CAD underwent low-dose prospective electrocardiogram-gated coronary CTA, with images reconstructed using IR. Image quality (IQ) of coronary segments were graded on a 4-point scale (4, excellent; 1, non-diagnostic). With invasive coronary angiography (ICA) considered the ''gold standard'', the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of coronary CTA were calculated on segment-, vessel- and patient-based levels. The patient data were divided into two groups (Agatston scores of ≥ 400 and <400). The differences in diagnostic performance between the two groups were tested. Diagnostic image quality was found in 98.1 % (1,232/1,256) of segments. The sensitivity, specificity, PPV, NPV and accuracy were 90.8 %, 95.3 %, 81.8 %, 97.8 % and 94.3 % (segment-based) and 97.2 %, 83.3 %, 94.6 %, 90.9 % and 93.8 % (patient-based). Significant differences between the two groups were seen in specificity, PPV and accuracy (92.1 % vs. 97.9 %, 76.0 % vs. 86.7 %, 91.7 % vs. 96.6 %, P < 0.05; segment-based). The average effective dose was 1.30 ± 0.15 mSv. Low-dose prospective coronary CTA with IR can acquire satisfactory image quality and show high diagnostic accuracy in patients with suspected CAD; however, blooming continues to pose a challenge in severely calcified segments. (orig.)

  4. Step and shoot coronary CT angiography using 256-slice CT: effect of heart rate and heart rate variability on image quality

    Energy Technology Data Exchange (ETDEWEB)

    Muenzel, D.; Noel, P.B.; Dorn, F.; Dobritz, M.; Rummeny, E.J.; Huber, A. [Klinikum rechts der Isar der Technischen Universitaet Muenchen, Department of Radiology, Munich (Germany)

    2011-11-15

    To evaluate the effect of heart rate variability (HRV) and heart rate (HR) on intra-image ''motion'' and inter-image ''stairstep'' artefacts in step-and-shoot coronary CT angiography (CCTA) using a wide detector CT scanner. 66 patients underwent step-and-shoot CCTA using 256-slice CT. Patients were divided into two groups (Group 1: HR <65 bpm, Group 2 {>=}65bpm). Motion artefacts were quantified using a 5-point-scale. Stairstep artefacts were defined by measurements of misalignment. Image noise, contrast-to-noise-ratio (CNR), signal-to-noise-ratio (SNR), and radiation dose were assessed. Mean HR was 66 {+-} 16.7 bpm (range: 45-125 bpm) and mean HRV was 10.7 {+-} 17.5 bpm. A significant correlation between HR and stairstep artefacts (r = 0.46, p < 0.001) and motion artefacts (r = 0.63, p < 0.001) was found. Group 2 showed significantly increased step artefacts with a mean misalignment of 1.4 mm compared to 0.4 mm in Group 1 (p < 0.001). There was no significant effect of HRV on stairstep artefacts (r = 0.15, p = 0.416) and motion artefacts (r = 0.13, p = 0.311). No significant differences in image noise, CNR, SNR, and radiation dose were seen. Unlike CCTA using narrow CT detectors, HRV has no significant effect on motion and stairstep artefacts using a wide CT detector with high z-coverage. However, a higher HR still increases stairstep and motion artefacts. (orig.)

  5. (18)F-FLT and (18)F-FDG PET-CT imaging in the evaluation of early therapeutic effects of chemotherapy on Walker 256 tumor-bearing rats.

    Science.gov (United States)

    Xu, Weina; Yu, Shupeng; Xin, Jun; Guo, Qiyong

    2016-12-01

    The present study aimed to evaluate the early therapeutic effects of chemotherapy on Walker 256 tumor-bearing Wistar rats via F-18-fluoro-3'-deoxy-3'-L-fluorothymidine ((18)F-FLT) and F-18-fluoro-deoxyglucose ((18)F-FDG) positron emission tomography-computed tomography (PET-CT) imaging. Walker 256 tumor-bearing Wistar rats were subjected to (18)F-FLT and (18)F-FDG PET-CT imaging prior to and 24 and 48 h after epirubicin chemotherapy. (18)F-FLT and (18)F-FDG uptake [tumor/muscle (T/M)], the percentage of injected dose per gram (% ID/g), and the Ki-67 labeling index (LI-Ki-67) were quantitatively determined for each rat prior to and following epirubicin chemotherapy. The correlation between % ID/g and tumor LI-Ki-67 was analyzed. Both (18)F-FLT and (18)F-FDG tumor uptake decreased significantly at 24 and 48 h after chemotherapy (Ptumor uptake correlated positively with LI-Ki-67 before and after chemotherapy (r=0.842 and 0.813, respectively). During the early post-chemotherapy stage, (18)F-FLT and (18)F-FDG uptake in Walker 256 tumors reduced significantly, which correlated positively with the tumor cell proliferative activity.

  6. Combination use of multiple interventional techniques for the treatment of prolapse of lumbar intervertebral disc: therapeutic observation in 256 cases%多种介入方法联合应用治疗腰椎间盘突出症256例疗效观察

    Institute of Scientific and Technical Information of China (English)

    李振; 阿斯哈尔; 谷淑梅

    2011-01-01

    Objective To observe the therapeutic effect of combination use of'multiple interventional techniques in treating lumbar intervertebral dise herniation. Methods Comhination use of ozone disc ablation. dissolution of disk with collagenase . windowing of fiber ring to reduce pressure within the disk and other endo-dise or extra-disc techniques was employed to treat 256 patients with lumbar intervertebral disc protrusion. The clinical results were analyzed and the technique was evaluated. Results Combination use of multiple interventional techniques was completed for 437 diseased lumbar disks in 256 patients. The therapeutic efficacy was judged hy Macnah criterion. Excellent effectiveness was obtained in 82.4% patients.And the response to treatment became better with time. The curative effect in patients with ruptured fiber ring was much better than that with no ruptured fiber ring. Conclusion Comhination use of multiple interventional techniques carries wide indications for the treatment of intervertebral disc protrusion and has excellent therapeutic efficacy. Collagenase has proteolytic effect on fiber ring, ozone possesses oxidation effect to the nucleus pulposus. and fiber ring windowing can reduce the pressure within the disk. All the above three techniques have their own distinguishing features. Based on imaging findings and the pressure within the disk, an optimal combination of theses techniques can surely bring satisfactory results. (J Intervent Radiol,2011, 20: 45-47)%目的 观察多种介入方法联合应用治疗腰椎间盘突出症的疗效.方法 采用臭氧盘内消融术、胶原酶溶解术、纤维环开窗减压术多种方法盘内、盘外联合应用治疗腰椎间盘突出症.结果 治疗腰椎间盘突出症256例,437个椎间盘,采用Macnab标准评价疗效,优良率82.4%;远期疗效似更佳,纤维环破裂组疗效优于未破裂组.结论 本项技术治疗腰椎间盘突出适应证广泛、疗效好,胶原酶对纤维环有溶

  7. 心率对256层CT前瞻性心电门控冠状动脉成像质量的影响%Prospectively ECG-gated coronary angiograhpy with 256-slice CT:impact of heart rate on image quality

    Institute of Scientific and Technical Information of China (English)

    张晓东; 赖紫霞; 唐秉航; 李芳云; 李良才; 黄晖; 何亚奇; 吴任国; 黄德成; 梁建雄

    2011-01-01

    目的:探讨心率对256层螺旋CT前瞻性心电门控冠状动脉成像质量的影响,并与回顾性心电门控进行对照分析。方法:156例患者行前瞻性心电门控冠状动脉检查,73例行回顾性心电门控冠状动脉检查,所有病例按心率分为<60次/分,60~69次/分,70~79次/分,80~89次/分,90~99次/分及≥100次/分共6组。对所有冠状动脉节段图像质量进行评分(4分法)。比较不同心率组间的图像质量;比较各心率组前瞻性心电门控与回顾性心电门控图像质量。记录前瞻性心电门控检查每例图像是否出现运动伪影,并对平均心率与运动伪影进行ROC曲线分析。结果:前瞻性心电门控检查,冠状动脉节段评分优良(1~2分)者在各心率组分别达96%、93%、80%、62%、45%和54%,不同心率组冠状动脉分段评估差异无显著性意义(P>0.05);回顾性心电门控检查,各心率组评分为优良者分别达100%、95%、90%、88%、92%和49%,不同心率组冠状动脉分段评估差异有显著性意义(P<0.05)。各组冠状动脉节段图像质量符合诊断要求的,在前瞻性心电门控检查时分别为100%、99%、98%、98%、98%和100%;回顾性心电门控检查时分别为100%、100%、99%、100%、100%和96%;除心率80~89次/分之外,前瞻性与回顾性心电门控检查能满足诊断图像质量者在各心率组间差异均无显著性意义(P>0.05)。前瞻性心电门控检查,ROC分析表明平均心率与运动伪影密切相关(AUC=0.783;95%CI:0.709~0.856;P<0.01)。结论:256层螺旋CT前瞻性心电门控冠状动脉成像时心率对冠状动脉节段图像质量无明显影响;前瞻性心电门控能获得与回顾性心电门控检查相似的能满足诊断需要的图像质量。平均心率影响冠状动脉运动伪影的出现,心率65.5次/分可作为冠状动脉出

  8. Iterative model reconstruction: Improved image quality of low-tube-voltage prospective ECG-gated coronary CT angiography images at 256-slice CT

    Energy Technology Data Exchange (ETDEWEB)

    Oda, Seitaro, E-mail: seisei0430@nifty.com [Department of Cardiology, MedStar Washington Hospital Center, 110 Irving Street, NW, Washington, DC 20010 (United States); Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Chuo-ku, Kumamoto, 860-8556 (Japan); Weissman, Gaby, E-mail: Gaby.Weissman@medstar.net [Department of Cardiology, MedStar Washington Hospital Center, 110 Irving Street, NW, Washington, DC 20010 (United States); Vembar, Mani, E-mail: mani.vembar@philips.com [CT Clinical Science, Philips Healthcare, c595 Miner Road, Cleveland, OH 44143 (United States); Weigold, Wm. Guy, E-mail: Guy.Weigold@MedStar.net [Department of Cardiology, MedStar Washington Hospital Center, 110 Irving Street, NW, Washington, DC 20010 (United States)

    2014-08-15

    Objectives: To investigate the effects of a new model-based type of iterative reconstruction (M-IR) technique, the iterative model reconstruction, on image quality of prospectively gated coronary CT angiography (CTA) acquired at low-tube-voltage. Methods: Thirty patients (16 men, 14 women; mean age 52.2 ± 13.2 years) underwent coronary CTA at 100-kVp on a 256-slice CT. Paired image sets were created using 3 types of reconstruction, i.e. filtered back projection (FBP), a hybrid type of iterative reconstruction (H-IR), and M-IR. Quantitative parameters including CT-attenuation, image noise, and contrast-to-noise ratio (CNR) were measured. The visual image quality, i.e. graininess, beam-hardening, vessel sharpness, and overall image quality, was scored on a 5-point scale. Lastly, coronary artery segments were evaluated using a 4-point scale to investigate the assessability of each segment. Results: There was no significant difference in coronary arterial CT attenuation among the 3 reconstruction methods. The mean image noise of FBP, H-IR, and M-IR images was 29.3 ± 9.6, 19.3 ± 6.9, and 12.9 ± 3.3 HU, respectively, there were significant differences for all comparison combinations among the 3 methods (p < 0.01). The CNR of M-IR was significantly better than of FBP and H-IR images (13.5 ± 5.0 [FBP], 20.9 ± 8.9 [H-IR] and 39.3 ± 13.9 [M-IR]; p < 0.01). The visual scores were significantly higher for M-IR than the other images (p < 0.01), and 95.3% of the coronary segments imaged with M-IR were of assessable quality compared with 76.7% of FBP- and 86.9% of H-IR images. Conclusions: M-IR can provide significantly improved qualitative and quantitative image quality in prospectively gated coronary CTA using a low-tube-voltage.

  9. Clinical Application and Therapeautic Effect of Fluorouracil Controlled Release Implant on Walker-256 Carcinosarcoma in the Liver of Wistar Rats%5-Fu控释剂对Walker-256移植性鼠肝癌的治疗效果及临床应用

    Institute of Scientific and Technical Information of China (English)

    贺银成; 袁月英; 陈纪伟; 乔建国; 史海安

    2000-01-01

    以硅橡胶囊为骨架,制成5氟尿嘧啶(5Fu)控释植入剂,观察对Walker256移植性鼠肝癌的治疗效果.实验分对照组(A组)及治疗组(B组),每组Wistar大鼠12只.结果A、B组带瘤大鼠生存时间分别为(28.0±2.2)及(38.7±6.7) d(P<0.01),B组抑瘤率为96.3%.光镜下见B组癌细胞片状坏死,外周肝细胞排列整齐,肝小叶结构存在.初步临床应用结果表明,5Fu控释剂对继发性肝癌治疗效果较好.

  10. 基于256层螺旋CT头颈部扫描的最优辐射剂量节省模式的实验研究%The experimental study of optimal radiation dosage saving mode based on the scan of head and neck using 256-slice CT

    Institute of Scientific and Technical Information of China (English)

    马恩森; 马国林; 王武; 任安

    2013-01-01

    目的 探讨在保证影像质量前提下的头颈部256层CT最优低剂量节省模式.方法 应用组织等效头颈部模型置于Philips Brilliance256层CT机以标准模式(400mAs)和低剂量节省模式进行分别扫描,其中低剂量节省模式包括自动管电流选择(ACS)、螺旋剂量节省(Helical Dose Saving)、X-Y平面动态电流调节(D-DOM)、Z轴动态电流调节技术(Z-DOM)等进行组合,测量、记录模型蝶鞍、下颌骨和胸骨柄各部位CT值、CT值噪声标准差(SD),分别行方差分析.结果 共有8种组合模式可降低辐射剂量.即:①ACS;②ACS+ Helical;③ACS+ (D-DOM);④ACS+ (Z-DOM);⑤ACS+ Helical +(D-DOM);⑥ACS+ (D-DOM)+ (Z-DOM);⑦ACS+ Helical--(Z-DOM);③ACS+ Helical+ (D-DOM)+(Z-DOM).与标准剂量CTDI26.5mGy,DLP1276.8 mGy* cm相比,CT不同剂量节省方式扫描时,在保证图像质量的同时,辐射剂量可节省11.21%~68.12%.采用最优剂量节省模式ACS+ Helical+(D-DOM)+(Z-DOM),CTDI从26mGy降低到11.8mGy,DLP从1134.6mGy* cm降低到504.9mGy* cm.蝶鞍、下颌骨和胸骨柄水平相同部位软组织和骨骼的CT值在各组间差异均无统计学意义(P≥0.05).蝶鞍、下颌骨水平骨骼结构测量的SD值有统计学差别(P<0.01),而胸骨柄水平骨骼SD值和蝶鞍、下颌骨、胸骨柄水平相同部位软组织SD值间差异均无统计学意义(P>0.05).结论 在头颈部螺旋CT扫描中,恰当运用螺旋CT剂量节省模式,辐射剂量可大大降低.%Objective To investigate the optimal low dose 256-slice CT scan mode of the head and neck on the promise to ensure image quality. Methods A head and neck phantom equivalent to human tissue was scaned by Philips Brilliance 256 slice-CT at standard dose(400 mAs)and low dose saving mode scanning, the low-dose saving mode includes automatic current selection (ACS), helical dose saving, dynamic angular dose modulation (D-DOM), Z-axis dose modulation (Z-DOM), and the combination of the above mode. The CT

  11. 2010年某大学5256例员工血脂、血糖体检结果分析%Analysis of blood lipids and glucoses levels in 5 256 cases of faculty of certain university in 2010

    Institute of Scientific and Technical Information of China (English)

    冯杨

    2012-01-01

    Objective To understand the health status of university staff and provide basis for medical treatment , diseases prevention and health care . Methods Health examination results of 5 256 cases of in-service teachers were analyzed .Results In total of 5 256 subjects , serum TG level of 972 cases were equal with or more than 1 .70 mmol/L, accounting for 21.66% , serum TC level of 438 cases were equal with or more than 6 .21 μmol/L, accounting for 9 .87% , serum GLU level of 314 cases were equal with or more than 6 .1 μmol/L, accounting for 7 .00% .Blood glucose and lipid levels increased with the increasing of age . And there were statistical difference between different genders , for males were higher than for females .Conclusion Medical treatment, diseases prevention and health care should be further strengthened to improve the staff s health level.%目的 了解高校员工的健康状况,同时为其医疗、预防保健提供依据.方法 对5 256例员工体检结果进行统计分析.结果 5 256例体检者血清测定中,三酰甘油(TG)≥1.70 μmol/L者972例,占21.66%;总胆固醇(TC)≥6.21 μmol/L者438例,占9.87%;血糖(GLU)≥6.1 μmol/L者314例,占7.00%.血糖、血脂水平存在年龄差异,随年龄增长而增高.同时也存在性别差异,男性较高于女性.结论 重视员工的医疗预防保健工作,提高员工的健康水平.

  12. Synthesis, radiolabeling and baboon SPECT imaging of 2{beta}-carbomethoxy-3{beta}-(3'-[{sup 123}I]iodophenyl)tropane ([{sup 123}I]YP256) as a serotonin transporter radiotracer

    Energy Technology Data Exchange (ETDEWEB)

    Bois, Frederic; Baldwin, Ronald M.; Amici, Louis; Al-Tikriti, Mohammed S. [Yale University, School of Medicine, VA Connecticut HCS (116A2), West Haven, CT 06516 (United States); Kula, Nora; Baldessarini, Ross [Department of Psychiatry and Neuroscience Program, Harvard Medical School, Mailman Research Center McLean Division of Massachusetts General Hospital, Belmont, MA 02478 (United States); Innis, Robert B.; Staley, Julie K. [Yale University, School of Medicine, VA Connecticut HCS (116A2), West Haven, CT 06516 (United States); Tamagnan, Gilles D. [Yale University, School of Medicine, VA Connecticut HCS (116A2), West Haven, CT 06516 (United States); Institute for Neurodegenerative Disorders, New Haven, CT 06510 (United States)], E-mail: gtamagnan@indd.org

    2008-01-15

    To develop a potential SPECT probe to evaluate the integrity of the serotoninergic system (5-HTT) whose dysfunction is linked to several disease conditions such as Parkinson's disease, Alzheimer's disease and depression, we report the synthesis, radiolabeling and in vivo baboon imaging of 2{beta}-carbomethoxy-3{beta}-(3'-[{sup 123}I]iodophenyl) tropane (YP256, ). The radiolabeling was performed by iododestannylation using sodium [{sup 123}I]iodide and peracetic acid. Although the ligand displayed high selectivity for 5-HTT over dopamine transporter in vitro, SPECT imaging in baboons did not reveal selective 5-HTT accumulation in brain in vivo.

  13. 低剂量256排螺旋 CT肺灌注扫描对非小细胞肺癌化疗疗效的评估%Evaluation of Low-dose 256 Spiral CT Lung Perfusion Scan for the Efficacy of Chemo-therapy for Non-small Cell Lung Cancer

    Institute of Scientific and Technical Information of China (English)

    舒圣捷; 王全; 周航; 刘白鹭; 李大庆; 李里; 娄阁; 王梓鹏

    2015-01-01

    目的:探讨低剂量256排螺旋CT肺灌注扫描对非小细胞肺癌化疗疗效的评估意义。方法对45例晚期非小细胞肺癌患者,在化疗前和化疗后40天分别进行CT灌注扫描。计算表面通透性( permeability surface,PS)、血流量(blood flow,BF)、血容量(blood volume,BV)和平均通过时间(mean transit time,MTT)、达峰时间(time to peak)。用RE-CIST( Response Evaluation Criteria In Solid Tumors)标准测量和比较化疗前后灌注值的均数间的差异。结果 Pearson相关检验结果显示BV和BF呈显著相关性(γ=0.48,P=0.001),达峰时间与PS相关(γ=0.31,P=0.04)、与血流量相关(γ=20.66,P,0.001)、与血容量相关(γ=20.39,P=0.007)。缓解组患者的BF、BV和PS高于其他组患者。结论 CT灌注成像可以评价晚期非小细胞肺癌患者化疗前后的血管生成,进而评估疗效。%Objective To explore the evaluation of the low-dose 256 spiral CT lung perfusion scan for the efficacy of chemotherapy for non-small cell lung cancer( NSCLC) .Methods 45 advanced NSCLC patients undergone CT perfusion scan be-fore chemotherapy and 40 days after chemotherapy respectively.To calculate the permeability surface (PS),blood flow (BF), blood volume ( BV) and mean transit time ( MTT) ,and time to peak.RECIST standard was used for measuring and calculating the difference of the mean perfusion value before and after chemotherapy.Results Pearson correlation test results showed that the BV and BF had significant correlation(γ=0.48,P=0.001),and time to peak was related with PS(γ=0.31,P=0.04),blood flow(γ=20.66,P=0.001),and blood volume(γ=20.39,P=0.007).BF,BV,and PS of ease group were higher than the other patients.Conclusion CT perfusion imaging can evaluate angiogenesis in patients with advanced NSCLC before and after chemo-therapy,and assess the efficacy.

  14. Whole-brain perfusion imaging and angiography performed with 256-slice CTin evaluation of cerebrovascular reserve capacity in unilateral carotid artery stenosis%256层CT全脑灌注成像联合CTA评估单侧颈动脉狭窄的脑血管储备能力的价值

    Institute of Scientific and Technical Information of China (English)

    唐健; 常军; 侯海燕; 姜旭栋; 堵红群; 姜建威

    2012-01-01

    Objective To assess the value of combination of whole-brain perfusion imaging and CTA in evaluating cerebrovascular reserve capacity in unilateral carotid artery stenosis. Methods Twenty-seven patients with unilateral carotid artery stenosis of ≥50% were divided into 2 groups according to CTA results: carotid moderate stenosis groupfcarotid stenosis of 50%-69%, group A) and carotid severe stenosis or occlusion group(carotid stenosis of ≥70% , group B). The relative cerebral blood volume(rCBV) , the relative cerebral blood folw(rCBF) , the difference in mean transit time(dMTT) and the difference in time to peak(dTTP) in bilateral temporal white matter and gray matter supplied by middle cerebral artery were measured and calculated. CTA was used to assess the configuration of the circle of Willis and if primary collaterals were patent. Differences in perfusion parameters between group A and group B, and between patients with patent primary collaterals or not were determined by using one way ANOVA test. Results There were statistical differences in rCBV, rCBF, dMTT and dTTP between two groups in white matter. Statistical difference of dMTT and dTTP was found between two groups in gray matter. There was significant increase in dTTP in the group B of the patients without patent primary collaterals. Conclusion Combined whole-brain perfusion imaging and CTA is a good way to evaluate cerebrovascular reserve capacity in unilateral carotid artery stenosis, and to provide a reliable method for choice of clinic treatments.%目的 探讨256层CT全脑灌注成像联合CTA评估单侧颈动脉狭窄的脑血管储备能力的价值.方法 单侧颈动脉狭窄≥50%的患者27例,根据CTA结果 按颈动脉狭窄程度划分为第一组中度狭窄组(血管阻塞50%~69%)和第二组重度狭窄或闭塞组(血管阻塞≥70%).测量并计算2组大脑中动脉供血区的白质和灰质的相对脑血容量(relative cerebral blood volume,r

  15. The Value of Diagnosing Rabbit VX2 Peritoneal Implantation Metastasis Tumor by 256 Line CT JOG-H Perfusion Scan%256排CT JOG-H模式灌注扫描诊断兔VX2腹膜腔移植瘤的诊断价值评价

    Institute of Scientific and Technical Information of China (English)

    佟元涛

    2015-01-01

    Objective To evaluate the value of diagnosing rabbit VX2 peritoneal implantation metastasis tumor by 256 line CT JOG-H perfusion scan. Method The rabbits were induced into tumor models by injecting suspended particle, then CT perfusion scan were used to scan the abdomen of rabbit model. Pathological result was taken as gold standard to evaluate CT perfusion scan.Results CT perfusion scan was superior than CT enhanced scan in detecting the metastatic tumor less than 10mm,10-20 mm by CT enhanced scan.Conclusion CT perfusion scan was superior than CT enhanced scan in detecting the metastatic tumor less than 20 mm. In the focus greater than 20 mm, CT perfusion scan was equal to CT enhanced scan .%目的:评估CT灌注对腹腔内移植瘤的诊断价值。方法制作兔VX2腹膜腔移植瘤模型,对瘤兔腹部进行CT灌注扫描获得影像学结果,以病理结果为金标准评价CT增强加CT灌注的诊断价值。结果在对<10 mm及对10~20 mm的腹腔种植瘤进行扫描对于病灶检出能力CT增强加CT灌注扫描要优于单纯CT增强扫描。结论对于20 mm以下的病灶CT增强加CT灌注扫描检出能力在敏感度、特异度、准确度方面优于单纯CT增强,而对于>20 mm的病灶CT增强与CT增强加CT灌注检出结果相同均与病理结果一致。

  16. Complete Circular Genome Sequence of Successful ST8/SCCmecIV Community-Associated Methicillin-Resistant Staphylococcus aureus (OC8) in Russia: One-Megabase Genomic Inversion, IS256’s Spread, and Evolution of Russia ST8-IV

    Science.gov (United States)

    Wan, Tsai-Wen; Higuchi, Wataru; Hung, Wei-Chun; Reva, Ivan V.; Singur, Olga A.; Gostev, Vladimir V.; Sidorenko, Sergey V.; Peryanova, Olga V.; Salmina, Alla B.; Reva, Galina V.; Teng, Lee-Jene; Yamamoto, Tatsuo

    2016-01-01

    ST8/SCCmecIV community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has been a common threat, with large USA300 epidemics in the United States. The global geographical structure of ST8/SCCmecIV has not yet been fully elucidated. We herein determined the complete circular genome sequence of ST8/SCCmecIVc strain OC8 from Siberian Russia. We found that 36.0% of the genome was inverted relative to USA300. Two IS256, oppositely oriented, at IS256-enriched hot spots were implicated with the one-megabase genomic inversion (MbIN) and vSaβ split. The behavior of IS256 was flexible: its insertion site (att) sequences on the genome and junction sequences of extrachromosomal circular DNA were all divergent, albeit with fixed sizes. A similar multi-IS256 system was detected, even in prevalent ST239 healthcare-associated MRSA in Russia, suggesting IS256’s strong transmission potential and advantage in evolution. Regarding epidemiology, all ST8/SCCmecIVc strains from European, Siberian, and Far Eastern Russia, examined had MbIN, and geographical expansion accompanied divergent spa types and resistance to fluoroquinolones, chloramphenicol, and often rifampicin. Russia ST8/SCCmecIVc has been associated with life-threatening infections such as pneumonia and sepsis in both community and hospital settings. Regarding virulence, the OC8 genome carried a series of toxin and immune evasion genes, a truncated giant surface protein gene, and IS256 insertion adjacent to a pan-regulatory gene. These results suggest that unique single ST8/spa1(t008)/SCCmecIVc CA-MRSA (clade, Russia ST8-IVc) emerged in Russia, and this was followed by large geographical expansion, with MbIN as an epidemiological marker, and fluoroquinolone resistance, multiple virulence factors, and possibly a multi-IS256 system as selective advantages. PMID:27741255

  17. The effect of head size/shape, miscentering, and bowtie filter on peak patient tissue doses from modern brain perfusion 256-slice CT: How can we minimize the risk for deterministic effects?

    Energy Technology Data Exchange (ETDEWEB)

    Perisinakis, Kostas; Seimenis, Ioannis; Tzedakis, Antonis; Papadakis, Antonios E.; Damilakis, John [Department of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 2208, Heraklion 71003, Crete (Greece); Medical Diagnostic Center ' Ayios Therissos,' P.O. Box 28405, Nicosia 2033, Cyprus and Department of Medical Physics, Medical School, Democritus University of Thrace, Panepistimioupolis, Dragana 68100, Alexandroupolis (Greece); Department of Medical Physics, University Hospital of Heraklion, P.O. Box 1352, Heraklion 71110, Crete (Greece); Department of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 2208, Heraklion 71003, Crete (Greece)

    2013-01-15

    Purpose: To determine patient-specific absorbed peak doses to skin, eye lens, brain parenchyma, and cranial red bone marrow (RBM) of adult individuals subjected to low-dose brain perfusion CT studies on a 256-slice CT scanner, and investigate the effect of patient head size/shape, head position during the examination and bowtie filter used on peak tissue doses. Methods: The peak doses to eye lens, skin, brain, and RBM were measured in 106 individual-specific adult head phantoms subjected to the standard low-dose brain perfusion CT on a 256-slice CT scanner using a novel Monte Carlo simulation software dedicated for patient CT dosimetry. Peak tissue doses were compared to corresponding thresholds for induction of cataract, erythema, cerebrovascular disease, and depression of hematopoiesis, respectively. The effects of patient head size/shape, head position during acquisition and bowtie filter used on resulting peak patient tissue doses were investigated. The effect of eye-lens position in the scanned head region was also investigated. The effect of miscentering and use of narrow bowtie filter on image quality was assessed. Results: The mean peak doses to eye lens, skin, brain, and RBM were found to be 124, 120, 95, and 163 mGy, respectively. The effect of patient head size and shape on peak tissue doses was found to be minimal since maximum differences were less than 7%. Patient head miscentering and bowtie filter selection were found to have a considerable effect on peak tissue doses. The peak eye-lens dose saving achieved by elevating head by 4 cm with respect to isocenter and using a narrow wedge filter was found to approach 50%. When the eye lies outside of the primarily irradiated head region, the dose to eye lens was found to drop to less than 20% of the corresponding dose measured when the eye lens was located in the middle of the x-ray beam. Positioning head phantom off-isocenter by 4 cm and employing a narrow wedge filter results in a moderate reduction of

  18. Quantification of aortic valve area at 256-slice computed tomography: Comparison with transesophageal echocardiography and cardiac catheterization in subjects with high-grade aortic valve stenosis prior to percutaneous valve replacement

    Energy Technology Data Exchange (ETDEWEB)

    Klass, Oliver, E-mail: oliver.klass@uniklinik-ulm.de [University Hospital of Ulm, Department of Diagnostic and Interventional Radiology, Steinhoevelstr. 9, 89075 Ulm (Germany); Walker, Matthew J.; Olszewski, Mark E. [Philips Healthcare, CT Clinical Science, Cleveland, OH (United States); Bahner, Johannes; Feuerlein, Sebastian; Hoffmann, Martin H.K.; Lang, Alexandra [University Hospital of Ulm, Department of Diagnostic and Interventional Radiology, Steinhoevelstr. 9, 89075 Ulm (Germany)

    2011-10-15

    Purpose: The purpose of this study was to compare planimetric aortic valve area (AVA) measurements from 256-slice CT to those derived from transesophageal echocardiography (TEE) and cardiac catheterization in high-risk subjects with known high-grade calcified aortic stenosis. Methods and materials: The study included 26 subjects (10 males, mean age: 79 {+-} 6; range, 61-88 years). All subjects were clinically referred for aortic valve imaging prior to percutaneous aortic valve replacement from April 2008 to March 2009. Two radiologists, blinded to the results of TEE and cardiac catheterization, independently selected the systolic cardiac phase of maximum aortic valve area and independently performed manual CT AVA planimetry for all subjects. Repeated AVA measurements were made to establish CT intra- and interobserver repeatability. In addition, the image quality of the aortic valve was rated by both observers. Aortic valve calcification was also quantified. Results: All 26 subjects had a high-grade aortic valve stenosis (systolic opening area <1.0 cm{sup 2}) via CT-based planimetry, with a mean AVA of 0.62 {+-} 0.18. In four subjects, TEE planimetry was precluded due to severe aortic valve calcification, but CT-planimetry was successfully performed with a mean AVA of 0.46 {+-} 0.23 cm{sup 2}. Mean aortic valve calcium mass score was 563.8 {+-} 526.2 mg. Aortic valve area by CT was not correlated with aortic valve calcium mass score. A bias and limits of agreement among CT and TEE, CT and cardiac catheterization, and TEE and cardiac catheterization were -0.07 [-0.37 to 0.24], 0.03 [-0.49 to 0.55], 0.12 [-0.39 to 0.63] cm{sup 2}, respectively. Differences in AVA among CT and TEE or cardiac catheterization did not differ systematically over the range of measurements and were not correlated with aortic valve calcium mass score. Conclusion: Planimetric aortic valve area measurements from 256-slice CT agree well with those derived from TEE and cardiac catheterization in

  19. Novel Nonsense Variants c.58C>T (p.Q20X) and c.256G>T (p.E85X) in the CHEK2 Gene Identified dentified in Breast Cancer Patients from Balochistan.

    Science.gov (United States)

    Baloch, Abdul Hameed; Khosa, Ahmad Nawaz; Bangulzai, Nasrullah; Shuja, Jamila; Naseeb, Hafiz Khush; Jan, Mohammad; Marghazani, Illahi Bakhsh; Kakar, Masood-Ul-Haq; Baloch, Dost Mohammad; Cheema, Abdul Majeed; Ahmad, Jamil

    2016-01-01

    Breast cancer is the most commonly occurring and leading cause of cancer deaths among women globally. Hereditary cases account 5-10% of all the cases and CHEK2 is considered as a moderate penetrance breast cancer risk gene. CHEK2 plays a crucial role in response to DNA damage to promote cell cycle arrest and repair DNA damage or induce apoptosis. Our objective in the current study was to analyze mutations in the CHEK2 gene related to breast cancer in Balochistan. A total of 271 individuals including breast cancer patients and normal subjects were enrolled. All 14 exons of CHEK2 were amplified and sequenced. The majority of the patients (>95%) had invasive ductal carcinomas (IDCs), 52.1% were diagnosed with tumor grade III and 56.1% and 27.5% were diagnosed with advance stages III and IV. Two novel nonsense variants i.e. c.58C>T (P.Q20X) and c.256G>T (p.E85X) at exon 1 and 2 in two breast cancer patients were identified in the current study. Both the variants identified were novel and have not been reported elsewhere.

  20. Novel Nonsense Variants c.58C>T (p.Q20X) and c.256G>T (p.E85X) in the CHEK2 Gene Identified in Breast Cancer Patients from Balochistan.

    Science.gov (United States)

    Baloch, Abdul Hameed; Khosa, Ahmad Nawaz; Bangulzai, Nasrullah; Shuja, Jamila; Naseeb, Hafiz Khush; Jan, Mohammad; Marghazani, Illahi Bakhsh; Kakar, MasoodulHaq; Baloch, Dost Mohammad; Cheema, Abdul Majeed; Ahmad, Jamil

    2016-01-01

    Breast cancer is very common and the leading cause of cancer deaths among women globally. Hereditary cases account for 510% of the total burden and CHEK2, which plays crucial role in response to DNA damage to promote cell cycle arrest and repair or induce apoptosis, is considered as a moderate penetrance breast cancer risk gene. Our objective in the current study was to analyze mutations in related to breast cancer. A total of 271 individuals including breast cancer patients and normal subjects were enrolled and all 14 exons of CHEK2 were amplified and sequenced. The majority of the patients (>95%) were affected with invasive ductal carcinoma (IDC), 52.1% were diagnosed with grade III tumors and 56.2% and 27.5% with advanced stages III and IV. Two novel nonsense variants i.e. c.58C>T (P.Q20X) and c.256G>T (p.E85X) at exon 1 and 2 in two breast cancer patients were identified, both novel and not reported elsewhere.

  1. Ge0.975Sn0.025 320  ×  256 imager chip for 1.6-1.9  μm infrared vision.

    Science.gov (United States)

    Chang, Chiao; Li, Hui; Ku, Chien-Te; Yang, Shih-Guo; Cheng, Hung Hsiang; Hendrickson, Joshua; Soref, Richard A; Sun, Greg

    2016-12-20

    We report the experimental fabrication and testing of a GeSn-based 320×256 image sensor focal plane array operating at -15°C in the 1.6-1.9 μm spectral range. For image readout, the 2D pixel array of Ge/GeSn/Ge p-i-n heterophotodiodes was flip-chip bonded to a customized silicon CMOS readout integrated circuit. The resulting camera chip was operated using back-side illumination. Successful imaging of a tungsten-filament light bulb was attained with observation of gray-scale "hot spot" infrared features not seen using a visible-light camera. The Ge wafer used in the present imaging array will be replaced in future tests by a germanium-on-silicon wafer offering thin-film Ge upon Si or on SiO2/Si. This is expected to increase the infrared responsivity obtained in back-side illumination, and it will allow an imager in a Si-based foundry to be manufactured. Our experiments are a significant step toward the realization of group IV near-mid-infrared imaging systems, such as those for night vision.

  2. Action of tacrolimus on Wistar rat kidneys implanted with Walker 256 carcinosarcoma Estudo da ação do tacrolimus em rins de ratos Wistar implantados com carcinossarcoma de Walker

    Directory of Open Access Journals (Sweden)

    Cristiano Machado Inácio

    2010-02-01

    Full Text Available PURPOSE: To evaluate the development of Walker 256 tumor in male Wistar rats treated with tacrolimus using an experimental kidney tumor model. METHODS: 40 male Wistar rats were divided into four groups: Tumor group (TU (n=10, Tacrolimus-Tumor group (TT (n=10, Tacrolimus group (TC (n=10 and Control group (C (n=10. Treatment with tacrolimus was performed in groups TT and TC. Under anesthesia, the right kidney of each animal of TU and TT was accessed through a supraumbilical incision and inoculated with a 0.1mL solution containing 2x10(6 tumor cells (Walker 256 carcinosarcoma tumor cells. Group TC was treated with a saline solution. All the animals of groups TC and TT were treated with tacrolimus (5mg/kg/day by gavage for 15 days. TU group animals received saline by gavage for 15 days. On the 15th postoperative day, all animals were submitted to euthanasia and blood sampling for analysis of serum creatinine (Cr and blood urea nitrogen (BUN. Abdominal gross examination was performed, the right kidney removed and prepared for histological analysis by hematoxylin-eosin staining. The resulting data were submitted to statistical analysis by ANOVA. RESULTS: Statistical significance was found when comparing creatinine level between groups TU, TT and TC -TT group culminated with a marked increased in creatinine levels (Cr=1.013 ± 0.3028 mg/mL, TU group (Cr=0.5670 ± 0.03536 mg/dL P=0.00256, TC group (Cr =0.711 ± 0.1653 mg/mL P= 0.02832. Statistical significance was found when comparing BUN levels in TT group (71.32 ± 17.14 mg/mL, compared with TU group (45.83 ± 5.046 mg/dL, P=0.000318. There were no statistically significant differences between groups TT and TC (61.23 ± 9.503 mg/mL P=0.7242. Histological analysis showed a poor evolution in TT group with multiple foci of hemorrhage and cortical invasion by the Walker tumor. CONCLUSION: The Tacrolimus-treated group developed a more aggressive tumor and a drug-related nephrotoxic effect.OBJETIVO: Avaliar

  3. 32 CFR 256.3 - Criteria.

    Science.gov (United States)

    2010-07-01

    ... adverse effects of a possible aircraft accident. (ii) DoD fixed wing runways are separated into two types... airspace or otherwise be hazardous to aircraft operations, and (2) land areas which are exposed to the health, safety or welfare hazards of aircraft operations. (b) Height of obstructions. The land area...

  4. 37 CFR 2.56 - Specimens.

    Science.gov (United States)

    2010-07-01

    ... indicate membership in the collective organization. (5) A certification mark specimen must show how a... of a union or other organization performed the work or labor on the goods or services. (c) A... be a digitized image in .jpg or .pdf format....

  5. 25 CFR 256.2 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... must include a properly installed system of piping and fixtures; (v) The electrical system must include... companion to aid in basic needs, such as dressing, preparing food, etc.; or severe heart and/or respiratory... tribes listed in the Federal Register pursuant to 25 CFR part 83, as recognized by and receiving...

  6. Reference: 256 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available in parallel with POL. We observe a strong dosage sensitivity at the meristem for ...nt analysis. POL and related phosphatases are dosage-sensitive regulators of meristem and organ development

  7. 30 CFR 256.5 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... States, and includes islands, transition and intertidal areas, salt marshes, wetlands, and beaches, which..., the contiguous zone, transitional and intertidal areas, salt marshes, and wetlands within the...

  8. 30 CFR 256.12 - Supplemental sales.

    Science.gov (United States)

    2010-07-01

    ... lease having a well with indicated hydrocarbons; the reservoir may or may not be interpreted to extend... Mexico Planning Areas. (e) The Director may disclose the classification of blocks in supplemental...

  9. 30 CFR 256.40 - Definitions.

    Science.gov (United States)

    2010-07-01

    ..., natural gasoline, and other natural gas products recovered by a process of absorption, adsorption, compression, or refrigeration cycling, or a combination of such processes. (h) Natural gas means a mixture...

  10. Planning/Evaluation Report 94-256.

    Science.gov (United States)

    Des Moines Public Schools, IA. Dept. of Information Management.

    The Des Moines (Iowa) Independent Community School District Department of Information Management provides leadership and management services for the district in the areas of strategic planning for district improvement, technology, telecommunications, accountability, program evaluation, research, testing/assessment, and student information. This is…

  11. BDML Metadata: 256 [SSBD[Archive

    Lifescience Database Archive (English)

    Full Text Available C BY-NC-SA 0.150 dd417ead-6cde-4952-8f16-a377db1adb9b 0.105 x 0.105 x 0.5 (micrometer), 40 (second) http://ssbd.qbic.riken.jp/data.../source/Ce_KK_P002/RNAi_Y47D3A.d_040930_02/ http://ssbd.qbic.riken.jp/data.../bdml/Ce_KK_P002/RNAi_Y47D3A.d_040930_02.bdml0.15.xml http://ssbd.qbic.riken.jp/data/pdpml/Ce..._KK_P002.pdpml0.05.xml http://ssbd.qbic.riken.jp/search/dd417ead-6cde-4952-8f16-a377db1adb9b/ http://ssbd.qbic.riken.jp/omero/webclient/?show=dataset-208 ...

  12. 40 CFR 256.50 - Requirements.

    Science.gov (United States)

    2010-07-01

    ... Drinking Water Act (42 U.S.C. 300f et seq.) and with the designation of sole source aquifers under section..., State implementation plan requirements impacting resource recovery systems). (i) The State plan shall... Insecticide, Fungicide and Rodenticide Act (7 U.S.C. 1362 et seq.; disposal and storage of pesticides...

  13. 76 FR 256 - Informed Consent Elements

    Science.gov (United States)

    2011-01-04

    ... elements which align with various ethics codes and apply to all clinical investigations regulated by FDA and clinical investigations that support applications for research or marketing permits for products... ethical research, patient advocacy organizations, health care attorneys, pharmacy and law students,...

  14. 17 CFR 256.01-7 - Records.

    Science.gov (United States)

    2010-04-01

    ... accounts and financial statements shall be maintained in accordance with Regulation S-X and Accounting... identification and audit. (b) The books and records referred to herein shall include not only accounting records... provisions of part 257 of this chapter. (d) The accounts may be further subdivided: Provided,...

  15. LinoSPAD: a time-resolved 256×1 CMOS SPAD line sensor system featuring 64 FPGA-based TDC channels running at up to 8.5 giga-events per second

    Science.gov (United States)

    Burri, Samuel; Homulle, Harald; Bruschini, Claudio; Charbon, Edoardo

    2016-04-01

    LinoSPAD is a reconfigurable camera sensor with a 256×1 CMOS SPAD (single-photon avalanche diode) pixel array connected to a low cost Xilinx Spartan 6 FPGA. The LinoSPAD sensor's line of pixels has a pitch of 24 μm and 40% fill factor. The FPGA implements an array of 64 TDCs and histogram engines capable of processing up to 8.5 giga-photons per second. The LinoSPAD sensor measures 1.68 mm×6.8 mm and each pixel has a direct digital output to connect to the FPGA. The chip is bonded on a carrier PCB to connect to the FPGA motherboard. 64 carry chain based TDCs sampled at 400 MHz can generate a timestamp every 7.5 ns with a mean time resolution below 25 ps per code. The 64 histogram engines provide time-of-arrival histograms covering up to 50 ns. An alternative mode allows the readout of 28 bit timestamps which have a range of up to 4.5 ms. Since the FPGA TDCs have considerable non-linearity we implemented a correction module capable of increasing histogram linearity at real-time. The TDC array is interfaced to a computer using a super-speed USB3 link to transfer over 150k histograms per second for the 12.5 ns reference period used in our characterization. After characterization and subsequent programming of the post-processing we measure an instrument response histogram shorter than 100 ps FWHM using a strong laser pulse with 50 ps FWHM. A timing resolution that when combined with the high fill factor makes the sensor well suited for a wide variety of applications from fluorescence lifetime microscopy over Raman spectroscopy to 3D time-of-flight.

  16. A workflow for multiclass determination of 256 pesticides in essential oils by liquid chromatography tandem mass spectrometry using evaporation and dilution approaches: Application to lavandin, lemon and cypress essential oils.

    Science.gov (United States)

    Fillatre, Yoann; Rondeau, David; Daguin, Antoine; Communal, Pierre-Yves

    2016-01-01

    This paper describes the determination of 256 multiclass pesticides in cypress and lemon essential oils (EOs) by the way of liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI/MS/MS) analysis using the scheduled selected reaction monitoring mode (sSRM) available on a hybrid quadrupole linear ion trap (QLIT) mass spectrometer. The performance of a sample preparation of lemon and cypress EOs based on dilution or evaporation under nitrogen assisted by a controlled heating were assessed. The best limits of quantification (LOQs) were achieved with the evaporation under nitrogen method giving LOQs≤10µgL(-1) for 91% of the pesticides. In addition the very satisfactory results obtained for recovery, repeatability and linearity showed that for EOs of relatively low evaporation temperature, a sample preparation based on evaporation under nitrogen is well adapted and preferable to dilution. By compiling these results with those previously published by some of us on lavandin EO, we proposed a workflow dedicated to multiresidue determination of pesticides in various EOs by LC-ESI/sSRM. Among the steps involved in this workflow, the protocol related to mass spectrometry proposes an alternative confirmation method to the classical SRM ratio criteria based on a sSRM survey scan followed by an information-dependent acquisition using the sensitive enhanced product ion (EPI) scan to generate MS/MS spectra then compared to a reference. The submitted workflow was applied to the case of lemon EOs samples highlighting for the first time the simultaneous detection of 20 multiclass pesticides in one EO. Some pesticides showed very high concentration levels with amounts greatly exceeding the mgL(-1).

  17. Milli-ampere modulation in prospectively and retrospectively electrocardiography gated coronary artery angiography%256层CT前瞻性及回顾性心电门控ECG电流调制技术的应用

    Institute of Scientific and Technical Information of China (English)

    李芳云; 唐秉航; 张晓东; 李良才; 吴任国; 何亚奇

    2011-01-01

    目的:探讨256层CT前瞻性及回顾性心电门控ECG电流调制技术图像质量及辐射剂量,探讨其临床应用价值。方法:160例患者分为3组:A组50例,采用回顾性心电门控技术,关闭ECG电流调控;B组50例,采用回顾性心电门控螺旋扫描,开启ECG电流调控;C组60例,采用前瞻性心电门控横轴面扫描,心率≤70次/分(32例)时数据采集时间窗设在R-R间期75%时相,心率>70次/分(28例)时,数据采集时间窗设在45%~50%R-R间期。冠状动脉分段采用美国心脏协会(AHA)15分段法,采用3分法评价图像质量,3分为优,2分为中等,1分为差,其中≥2分为合格。在横轴面图像上左冠状动脉主干自左窦发出的层面测量升主动脉中心部的噪声值。对3组图像质量评分、图像噪声、容积CT剂量指数(CTDIvol)、剂量长度乘积(DLP)、有效剂量(ED)进行方差分析。结果:①三组图像质量评分中,A组中99.3%节段(609/612)为可评价节段,B组为99.1%节段(607/615),C组为98.9%节段(732/740),三组间差异无统计学意义(P>0.05);②心率≤70次/分和>70次/分时3组可评价率无明显差异,但心率>70次/分时A、B组优秀率无差异,但A组与C组、B组与C组冠脉段数的优秀率有差异;③三组图像噪声值分别为32.95士5.49、32.7士5.14和33.47士5.5,三组间差异无统计学意义(P>0.05);④三组CTDIvol均值分别为(62.52±4.67)、(50.56±9.76)和(17.47±7.42)mGy,三组ED值分别为(15.3±1.44)、(13.05±2.34)和(3.06±1.23)mSv。B组有效剂量比A组减少约13%,C组比A组有效剂量减少约80%,三组间差异有极显著性意义(P<0.01)。结论:采用前瞻性心电门控技术显著降低辐射剂量且不受心率的影响,当需要进行心功能分析或心瓣膜痛动态观察时,可以采用ECG电流调制技术降低辐射剂量。%Objective:To evaluate the impact of

  18. Time Series Analysis For The Californium Source In Sudbury Neutrino Observatory

    CERN Document Server

    Labranche, H

    2004-01-01

    The Sudbury Neutrino Observatory uses a 252Cf source to measure the neutron detection efficiency of its detector. We propose a method, the Time Series Analysis, that uses pairs of time intervals between the detected events to find the neutron detection efficiency, the probability to detect from a fission the prompt γ-rays, the neutron mean life inside the detector, the source fission rate and the residual activity rate from non-fission events. We explain our theoretical model of the source and the procedure to fit the data. With a 2.5 MeV threshold cut on the data, the neutron mean life is 5.281 ± 0.004(stat) msec and the source fission rate at June 12, 2001 is 4.360 ± 0.004(stat) sec −1. At this moment, the Time Series can only be applied to data when the source is near the centre. The technique is also applied with an AmBe source. We also show the latest progress to improve the technique. Finally, we briefly show another method, the Multiplicity Analysis, which was ...

  19. Design and Potentials of the Californium-252 Radiation Facility at WES

    Science.gov (United States)

    1975-09-01

    standards, using an Image Quality Indicator (IQI) and also a Beam Purity Indicator (BPI),** shows a relatively good thermal and epithermal neutron ...colli-nated beam of the desired neutron radiation. Consideration of the basic nuclear properties was therefore a necessity in achieving the desired...The upper 6 ft has been designed for use in radiography and neutron counting. The steel tank was prefabricated in two sections. The lower 6-ft

  20. Design of a californium-based epithermal neutron beam for neutron capture therapy.

    Science.gov (United States)

    Yanch, J C; Kim, J K; Wilson, M J

    1993-08-01

    The potential of the spontaneously fissioning isotope, 252Cf, to provide epithermal neutrons for use in boron neutron capture therapy (BNCT) has been investigated using Monte Carlo simulation. The Monte Carlo code MCNP was used to design an assembly composed of a 26 cm long, 11 cm radius cylindrical D2O moderator followed by a 64 cm long Al filter. Lithium filters are placed between the moderator and the filter and between the Al and the patient. A reflector surrounding the moderator/filter assembly is required in order to maintain adequate therapy flux at the patient position. An ellipsoidal phantom composed of skull- and brain-equivalent material was used to determine the dosimetric effect of this beam. It was found that both advantage depths and advantage ratios compare very favourably with reactor and accelerator epithermal neutron sources. The dose rate obtainable, on the other hand, is 4.1 RBE cGy min-1, based on a very large (1.0 g) source of 252Cf. This dose rate is two to five times lower than those provided by existing reactor beams and can be viewed as a drawback of using 252Cf as a neutron source. Radioisotope sources, however, do offer the advantage of in-hospital installation.

  1. Effect of polypeptide extract from scorpion venom on tumor growth and cellular immunity in rats with W256 sarcocarcinoma%蝎毒多肽提取物对肿瘤生长和细胞免疫功能的影响

    Institute of Scientific and Technical Information of China (English)

    张维东; 张月英; 王朝霞; 王兆朋; 贾青

    2007-01-01

    目的:观察蝎毒多肽提取物(PESV)对大鼠W256癌肉瘤抑制作用及其对荷瘤大鼠细胞免疫功能的影响.方法:将30只Wistar荷瘤大鼠,随机分为模型组、5-FU治疗组和蝎毒治疗组,连续灌胃给蝎毒多肽提取物7 d,处死,计算各组抑瘤率;流式细胞术(FCM)检测外周血T淋巴细胞亚群变化;酶联免疫吸附试验(ELISA)法测定血清中细胞因子INF-γ和IL-4含量.结果:蝎毒治疗组抑瘤率为55.21%.与模型组相比较,蝎毒治疗组荷瘤大鼠外周血中CD4+T细胞比例明显提高,CD8+T细胞明显降低,CD4+T/CD8+T值明显增高,差异均具有统计学意义(P<0.05);血清中细胞因子INF-γ含量明显升高,而IL-4含量显著降低,差异均具有统计学意义(P<0.05).结论:蝎毒多肽提取物对W256荷瘤大鼠肿瘤有明显抑制作用,通过提高细胞免疫功能,逆转荷瘤机体Th1/Th2漂移,改变荷瘤机体免疫抑制状态,发挥抗肿瘤作用.

  2. General Criteria for Waterfront Construction. Design Manual 25.6.

    Science.gov (United States)

    1981-07-01

    25.6-43 INCLINED qTIRRUPS , NEGATIVE REINFORCEMENT SUPPORT- ._SUPPORT POSITIVE REINFOC ENT I) CONSTRUCTION CRACK N\\CRACKS LINES OF TENSILE STRESS...Pue to Cracking of Reinforced Co rrete Member 25.6-44 II STIRRU EAM NEGATIVE REINFORCEMENT SU P RI Z.. .. SUPPORT POSITIVE REINFORCEMENT I

  3. Dicty_cDB: CFC256 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available nificant alignments: (bits) Value N BD092935 |BD092935.1 Methods and compositions... for synthesis of longfatty acids in plants. 1306 0.0 1 BD082645 |BD082645.1 Methods and compositions for sy...nthesis of long chain polyunsaturated fatty acids. 1306 0.0 1 BD082630 |BD082630.1 Methods and compositions

  4. Dicty_cDB: AFO256 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available oducing significant alignments: (bits) Value N AZ549565 |AZ549565.1 ENTGD95TF Entamoeba histolytica Shear...TCI79TR Entamoeba histolytica Sheared DNA Entamoeba histolytica genomic, DNA sequence. 42 1.5 1 AZ688547 |AZ...688547.1 ENTIN90TR Entamoeba histolytica Sheared DNA Entamoeba histolytica genomi...c, DNA sequence. 42 1.5 1 BH148090 |BH148090.1 ENTQM09TR Entamoeba histolytica Sheared DNA Entamoeba histoly...tica genomic, DNA sequence. 42 1.5 1 BH131557 |BH131557.1 ENTOL83TF Entamoeba histolytica Sheared DNA Entamo

  5. Dicty_cDB: SHA256 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available NA. 244 1e-70 3 BI863585 |BI863585.1 kx46a06.y1 Parastrongyloides trichosuri FL pAMP1 v1 Chiapelli McCarter Parastrongyloides...CTOR 2 ;, mRNA sequence. 66 4e-18 4 BI863575 |BI863575.1 kx45h07.y1 Parastrongyloides trichosuri FL pAMP1 v1...;, mRNA sequence. 66 9e-15 3 BI451383 |BI451383.1 kx23e09.y1 Parastrongyloides tr...ichosuri FL pAMP1 v1 Chiapelli McCarter Parastrongyloides trichosuri cDNA 5' similar to SW:EF2_CAEEL P29691 ... Chiapelli McCarter Parastrongyloides trichosuri cDNA 5' similar to SW:EF2_CHICK Q90705 ELONGATION FACTOR 2

  6. 40 CFR 98.256 - Data reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... number). (6) If you use Equation Y-1 of this subpart, the annual volume of flare gas combusted (in scf/year) and the annual average molecular weight (in kg/kg-mole) and carbon content of the flare gas (in kg carbon per kg flare gas). (7) If you use Equation Y-2 of this subpart, the annual volume of...

  7. Dicty_cDB: SLA256 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available oducing significant alignments: (bits) Value N BD092935 |BD092935.1 Methods and compositions for synthesis o...f longfatty acids in plants. 1479 0.0 1 BD082645 |BD082645.1 Methods and compositions for synthesis of long ...chain polyunsaturated fatty acids. 1479 0.0 1 BD082630 |BD082630.1 Methods and composition

  8. 17 CFR 256.223 - Advances from associate companies.

    Science.gov (United States)

    2010-04-01

    ... settlement which are includable in account 233, Notes payable to associate companies or account 234, Accounts... (CONTINUED) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC... account shall include the principal amount of notes and balances on open accounts due to...

  9. Dicty_cDB: SSL256 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available NcEST3a21h12.y1 Nc 1314 Tachyzoite cDNA Neospora caninum cDNA 5' similar to TR:Q9ZNS3 Q9ZNS3 RIBOSOMAL PROT...EIN S27. ;, mRNA sequence. 36 0.27 2 BG235080 |BG235080.1 NcEST3a40b01.y1 Nc 1314 Tachyzoite cDNA Neospora c...9095.1 NcEST3a07a05.y1 Nc 1314 Tachyzoite cDNA Neospora caninum cDNA 5' similar t

  10. Dicty_cDB: AFI256 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available LKHIAQTCMKLANG KYLLHRDPNRNVINLYSVPENAFDXIEEETQEEEEEXQSKGWVEESRE*thyxy*ptpys pispiqifixnifrik*d Translated Am...CMKLANG KYLLHRDPNRNVINLYSVPENAFDXIEEETQEEEEEXQSKGWVEESRE*thyxy*ptpys pispiqifixnifrik*d Homology vs CSM-cDNA

  11. 38 CFR 3.256 - Eligibility reporting requirements.

    Science.gov (United States)

    2010-07-01

    ...) Income; (2) Net worth or corpus of estate; (3) Marital status; (4) Nursing home patient status; (5... unless the Secretary determines that doing so is necessary to preserve program integrity. (3) Except for... circumstances: (i) If the Social Security Administration has not verified the beneficiary's Social...

  12. 28 CFR 2.56 - Disclosure of Parole Commission file.

    Science.gov (United States)

    2010-07-01

    ... Parole Commission is exempt from the record disclosure provisions of the Privacy Act of 1974, as well as... section. In no event will the Commission consider satisfaction of a request under this section, the... expected to pose an imminent threat to the life or physical safety of an individual; or (ii) With...

  13. 17 CFR 256.154 - Materials and supplies.

    Science.gov (United States)

    2010-04-01

    ... cumulative average, first-in-first-out, or such other method of inventory accounting as conforms with generally accepted accounting standards consistently applied. ...) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC...

  14. 49 CFR 256.13 - Review and approval of applications.

    Science.gov (United States)

    2010-10-01

    ...; (2) Demonstrate the advantages of joint use terminal facilities to carriers; (3) Demonstrate a more comprehensive and effective network of energy efficient surface common carrier transportation services through... services and for providing an appropriate focal point for civic and cultural activities; (6)...

  15. Dicty_cDB: SSJ256 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SGDGLYEGLDWLSNTLTSSSK*mt*evnliefirffnylii *lnycclilk*kkkkpclyk***ik*****kkkkkknplkilcdctqk Translated Amino ...RSRKWYIQSTCATSGDGLYEGLDWLSNTLTSSSK*mt*evnliefirffnylii *lnycclilk*kkkkpclyk***ik*

  16. Dicty_cDB: SLH256 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available BT080943 |pid:none) Caligus clemensi clone ccle-evs-51... 73 3e-12 BT076915_1( BT076915 |pid:none) Caligus roger...cresseyi clone crog-e... 69 7e-11 BT077060_1( BT077060 |pid:none) Caligus rogercresseyi clone crog-e...

  17. 256层CT上肢血管成像对血液透析患者自体动静脉内瘘功能不全的评价%Multi-slice CT angiography evaluation of autogenous arteriovenous fistula dysfunction in hemodialysis patients

    Institute of Scientific and Technical Information of China (English)

    金文韬; 李斌; 刘洪超; 刘士远; 郝楠馨; 于红

    2013-01-01

    Objective To evaluate the clinical value of CT angiography (CTA) using 256-slicc CT scanner for autogenous arteriovenous fistula dysfunction in hemodialysis patients. Methods A total of 20 hemodialysis patients with autogenous arteriovenous fistula dysfunction underwent CTA of the affected upper limbs. A total of 80-100 ml- of noniodinatcd contrast agent (iopamidol) was injected at a rate of 3-1. 5 mL/s into the antccubital vein of contralatcral limb. A contrast agent concentration tracking technology was utilized. Aortic arch was regarded as the region of interest (ROI) and the threshold was set at 150 HU. Imaging commenced after a delay of 18 s when ROI arrived at the threshold. In two patients, the delay phase scanning was started at 30 s after the first scanning . The images were reconstructed with standard algorithm, with 0. 625 mm slice thickness and 0. 625 mm slice gap, using different postprocessing techniques such as surface reconstruction, multiple planar reconstruction, maximum intensity projection and volume rendering on the EBW workstation. The cross sectional area of the fistula anastomotic stoma was measured using the vessel analysis and measurement function of the EBW workstation, and compared with the supplying artery. Results The blood vessels in affected limb were clearly displayed on CTA. Of 94 vascular segments in 20 hemodialysis patients, 29 were of stenosis, including 15 at arteriovenous anastomotic stoma (51.7%), 8 at venous outflow in forearm (27.5%), 3 at venous outflow in upper arm ( 10. 3 % ) and 3 at subclavian vein ( 10. 3%). Five cases exhibited collateral circulation formation; 10 had draining vein dilatation; 9 had supplying artery variation and 1 had hematoma in the elbow. Conclusion Autogenous arteriovenous fistula can be accurately evaluated by using CT angiography, which is helpful for guiding management clinically of the patients with chronic renal failure fistula dysfunction.%目的 研究256层CT血管成像对于血液透

  18. Determination of the optimum-size californium-252 neutron source for borehole capture gamma-ray analysis

    Science.gov (United States)

    Senftle, F.E.; Macy, R.J.; Mikesell, J.L.

    1979-01-01

    The fast- and thermal-neutron fluence rates from a 3.7 ??g 252Cf neutron source in a simulated borehole have been measured as a function of the source-to-detector distance using air, water, coal, iron ore-concrete mix, and dry sand as borehole media. Gamma-ray intensity measurements were made for specific spectral lines at low and high energies for the same range of source-to-detector distances in the iron ore-concrete mix and in coal. Integral gamma-ray counts across the entire spectrum were also made at each source-to-detector distance. From these data, the specific neutron-damage rate, and the critical count-rate criteria, we show that in an iron ore-concrete mix (low hydrogen concentration), 252Cf neutron sources of 2-40 ??g are suitable. The source size required for optimum gamma-ray sensitivity depends on the energy of the gamma ray being measured. In a hydrogeneous medium such as coal, similar measurements were made. The results show that sources from 2 to 20 ??g are suitable to obtain the highest gamma-ray sensitivity, again depending on the energy of the gamma ray being measured. In a hydrogeneous medium, significant improvement in sensitivity can be achieved by using faster electronics; in iron ore, it cannot. ?? 1979 North-Holland Publishing Co.

  19. Optical transitions in highly charged californium ions with high sensitivity to variation of the fine-structure constant.

    Science.gov (United States)

    Berengut, J C; Dzuba, V A; Flambaum, V V; Ong, A

    2012-08-17

    We study electronic transitions in highly charged Cf ions that are within the frequency range of optical lasers and have very high sensitivity to potential variations in the fine-structure constant, α. The transitions are in the optical range despite the large ionization energies because they lie on the level crossing of the 5f and 6p valence orbitals in the thallium isoelectronic sequence. Cf(16+) is a particularly rich ion, having several narrow lines with properties that minimize certain systematic effects. Cf(16+) has very large nuclear charge and large ionization energy, resulting in the largest α sensitivity seen in atomic systems. The lines include positive and negative shifters.

  20. Keno-Nr a Monte Carlo Code Simulating the Californium -252-SOURCE-DRIVEN Noise Analysis Experimental Method for Determining Subcriticality

    Science.gov (United States)

    Ficaro, Edward Patrick

    The ^{252}Cf -source-driven noise analysis (CSDNA) requires the measurement of the cross power spectral density (CPSD) G_ {23}(omega), between a pair of neutron detectors (subscripts 2 and 3) located in or near the fissile assembly, and the CPSDs, G_{12}( omega) and G_{13}( omega), between the neutron detectors and an ionization chamber 1 containing ^{252}Cf also located in or near the fissile assembly. The key advantage of this method is that the subcriticality of the assembly can be obtained from the ratio of spectral densities,{G _sp{12}{*}(omega)G_ {13}(omega)over G_{11 }(omega)G_{23}(omega) },using a point kinetic model formulation which is independent of the detector's properties and a reference measurement. The multigroup, Monte Carlo code, KENO-NR, was developed to eliminate the dependence of the measurement on the point kinetic formulation. This code utilizes time dependent, analog neutron tracking to simulate the experimental method, in addition to the underlying nuclear physics, as closely as possible. From a direct comparison of simulated and measured data, the calculational model and cross sections are validated for the calculation, and KENO-NR can then be rerun to provide a distributed source k_ {eff} calculation. Depending on the fissile assembly, a few hours to a couple of days of computation time are needed for a typical simulation executed on a desktop workstation. In this work, KENO-NR demonstrated the ability to accurately estimate the measured ratio of spectral densities from experiments using capture detectors performed on uranium metal cylinders, a cylindrical tank filled with aqueous uranyl nitrate, and arrays of safe storage bottles filled with uranyl nitrate. Good agreement was also seen between simulated and measured values of the prompt neutron decay constant from the fitted CPSDs. Poor agreement was seen between simulated and measured results using composite ^6Li-glass-plastic scintillators at large subcriticalities for the tank of uranyl nitrate. It is believed that the response of these detectors is not well known and is incorrectly modeled in KENO-NR. In addition to these tests, several benchmark calculations were also performed to provide insight into the properties of the point kinetic formulation.

  1. Accurate determination of Curium and Californium isotopic ratios by inductively coupled plasma quadrupole mass spectrometry (ICP-QMS) in 248Cm samples for transmutation studies

    Energy Technology Data Exchange (ETDEWEB)

    Gourgiotis, A.; Isnard, H.; Aubert, M.; Dupont, E.; AlMahamid, I.; Cassette, P.; Panebianco, S.; Letourneau, A.; Chartier, F.; Tian, G.; Rao, L.; Lukens, W.

    2011-02-01

    The French Atomic Energy Commission has carried out several experiments including the mini-INCA (INcineration of Actinides) project for the study of minor-actinide transmutation processes in high intensity thermal neutron fluxes, in view of proposing solutions to reduce the radiotoxicity of long-lived nuclear wastes. In this context, a Cm sample enriched in {sup 248}Cm ({approx}97 %) was irradiated in thermal neutron flux at the High Flux Reactor (HFR) of the Laue-Langevin Institute (ILL). This work describes a quadrupole ICP-MS (ICP-QMS) analytical procedure for precise and accurate isotopic composition determination of Cm before sample irradiation and of Cm and Cf after sample irradiation. The factors that affect the accuracy and reproducibility of isotopic ratio measurements by ICP-QMS, such as peak centre correction, detector dead time, mass bias, abundance sensitivity and hydrides formation, instrumental background, and memory blank were carefully evaluated and corrected. Uncertainties of the isotopic ratios, taking into account internal precision of isotope ratio measurements, peak tailing, and hydrides formations ranged from 0.3% to 1.3%. This uncertainties range is quite acceptable for the nuclear data to be used in transmutation studies.

  2. Radiological Characterization Technical Report on Californium-252 Sealed Source Transuranic Debris Waste for the Off-Site Source Recovery Project at Los Alamos National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Feldman, Alexander [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-04-24

    This document describes the development and approach for the radiological characterization of Cf-252 sealed sources for shipment to the Waste Isolation Pilot Plant. The report combines information on the nuclear material content of each individual source (mass or activity and date of manufacture) with information and data on the radionuclide distributions within the originating nuclear material. This approach allows for complete and accurate characterization of the waste container without the need to take additional measurements. The radionuclide uncertainties, developed from acceptable knowledge (AK) information regarding the source material, are applied to the summed activities in the drum. The AK information used in the characterization of Cf-252 sealed sources has been qualified by the peer review process, which has been reviewed and accepted by the Environmental Protection Agency.

  3. 3-(4-Bromophenylsulfinyl-2,5,6-trimethyl-1-benzofuran

    Directory of Open Access Journals (Sweden)

    Uk Lee

    2013-08-01

    Full Text Available In the title compound, C17H15BrO2S, the dihedral angle between the mean plane [r.m.s. deviation = 0.003 (2 Å] of the benzofuran ring system and the mean plane [r.m.s. deviation = 0.006 (2 Å] of the 4-bromophenyl ring is 83.09 (7°. In the crystal, weak C—H...π interactions are observed.

  4. 31 CFR 256.10 - Who may request payment from the Judgment Fund?

    Science.gov (United States)

    2010-07-01

    ... (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE OBTAINING PAYMENTS FROM... from the Judgment Fund? (a) Court judgments and settlements of litigation. The Department of Justice... litigating authority may submit a request for payment themselves if the Department of Justice is...

  5. 19 CFR 10.256 - Maintenance of records and submission of Certificate by importer.

    Science.gov (United States)

    2010-04-01

    ... same in all material respects, including physical characteristics, quality, and reputation. (c...-commercial importation of an article; or (iii) A commercial importation of an article whose value does...

  6. Draft Genome Sequence of Dematiaceous Coelomycete Pyrenochaeta sp. Strain UM 256, Isolated from Skin Scraping.

    Science.gov (United States)

    Yew, Su Mei; Chan, Chai Ling; Soo-Hoo, Tuck Soon; Na, Shiang Ling; Ong, Seong Siang; Hassan, Hamimah; Ngeow, Yun Fong; Hoh, Chee Choong; Lee, Kok Wei; Yee, Wai Yan; Ng, Kee Peng

    2013-05-30

    Pyrenochaeta, classified under the order Pleosporales, is known to cause diseases in plants and humans. Here, we report a draft genome sequence of a Pyrenochaeta sp. isolated from a skin scraping, with an estimated genome size of 39.4 Mb. Genes associated with the synthesis of proteases, toxins, plant cell wall degradation, and multidrug resistance were found.

  7. 32 CFR 256.10 - Air installations compatible use zone noise descriptors.

    Science.gov (United States)

    2010-07-01

    ... available in the Office of the Assistant Secretary of Defense (Installations and Logistics)—IO, Washington... frequencies to insure a description most representative of actual human response....

  8. Establishment of Animal Model for Bone Metastasis of Walker 256 Breast Cancer Cells

    Institute of Scientific and Technical Information of China (English)

    PANG; Fang-fang; SHEN; Hong-tao; HE; Ming; DONG; Ke-jun; WU; Shao-yong; DOU; Liang; SHI; Yan-jun; ZHANG; Shuang; WANG; Xiao-ming; ZHAO; Qin-zhang; YANG; Xu-ran; XU; Yong-ning; LAN; Xiao-xi; CAI; Li; JIANG; Shan

    2013-01-01

    Bone metastasis is a common complication of cancer.It often occurs in lung,breast and prostate cancer,and may cause osteolytic lesions,or cause few osteoblastic lesions.It has already advanced cancer When cancer metastasis to bone,which usually cannot be cured.It is one of the important factors leading to the death of cancer patients.Studying animal model of bone

  9. 17 CFR 256.01-4 - Construction or service contracts, and centralized procurement accounting.

    Science.gov (United States)

    2010-04-01

    ... classification of expenditures relating to projects as will meet the accounting requirements of the company for... COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 General Instructions... or service contracts, under which the service company undertakes projects to construct...

  10. 2-(5,6-Diphenyl-1,2,4-triazin-3-ylaniline

    Directory of Open Access Journals (Sweden)

    Mariusz Mojzych

    2012-12-01

    Full Text Available The title compound, C21H16N4, obtained under standard Suzuki cross-coupling conditions, is a model compound in the synthesis and biological activity evaluation of new aza-analogues of sildenafil containing a pyrazolo[4,3-e][1,2,4]triazine system. An N—H...N intramolecular hydrogen bond involving the aminobenzene system and the 1,2,4-triazine moiety helps to establish a near coplanar orientation of the rings with a dihedral angle of 12.04 (4°, which is believed to be necessary for the biological activity of sildenafil analogues. The 1,2,4-triazine ring is slightly distorted from planarity [r.m.s deviation = 0.0299 (11 Å] and forms dihedral angles of 58.60 (4 and 36.35 (3° with the pendant phenyl rings. The crystal packing features bifurcated N—H...(N,N hydrogen bonds linking screw-axis-related molecules into chains parallel to the [010] direction< and π–π interactions, with a centroid–centroid separation of 3.8722 (7 Å and a slippage of 1.412 (3 Å. The crystal studied was a nonmerohedral twin with a ratio of 0.707 (2:0293 (2.

  11. Constellation Shaping for WDM systems using 256QAM/1024QAM with Probabilistic Optimization

    CERN Document Server

    Yankov, Metodi P; da Silva, Edson P; Forchhammer, Søren; Larsen, Knud J; Oxenløwe, Leif K; Galili, Michael; Zibar, Darko

    2016-01-01

    In this paper, probabilistic shaping is numerically and experimentally investigated for increasing the transmission reach of wavelength division multiplexed (WDM) optical communication system employing quadrature amplitude modulation (QAM). An optimized probability mass function (PMF) of the QAM symbols is first found from a modified Blahut-Arimoto algorithm for the optical channel. A turbo coded bit interleaved coded modulation system is then applied, which relies on many-to-one labeling to achieve the desired PMF, thereby achieving shaping gain. Pilot symbols at rate at most 2% are used for synchronization and equalization, making it possible to receive input constellations as large as 1024QAM. The system is evaluated experimentally on a 10 GBaud, 5 channels WDM setup. The maximum system reach is increased w.r.t. standard 1024QAM by 20% at input data rate of 4.65 bits/symbol and up to 75% at 5.46 bits/symbol. It is shown that rate adaptation does not require changing of the modulation format. The performanc...

  12. Investigation on steam oxidation behaviour of TP347H FG Part I Exposure at 256 bar

    DEFF Research Database (Denmark)

    Jianmin, J; Montgomery, Melanie; Larsen, OH;

    2005-01-01

    The stainless steel TP347H FG is a candidate material for the final stage tubing of superheater and reheater sections of ultra supercritical boilers operated at steam temperatures up to 620C in the mild corrosion environments of coal-firing. A series of field tests has been conducted...... with the aforementioned steel in coal-fired boilers and this paper focuses on the steam oxidation behaviour for specimens tested at various metal temperatures for exposure times of 7700, 23000 and 30000 hours as investigated by light optical and scanning electron microscopy. The oxide present on the specimens is a duplex...

  13. Constellation Shaping for WDM systems using 256QAM/1024QAM with Probabilistic Optimization

    DEFF Research Database (Denmark)

    Yankov, Metodi Plamenov; Da Ros, Francesco; Porto da Silva, Edson;

    2016-01-01

    In this paper, probabilistic shaping is numerically and experimentallyinvestigated for increasing the transmission reach of wavelength divisionmultiplexed (WDM) optical communication system employing quadrature amplitudemodulation (QAM). An optimized probability mass function (PMF) of the QAMsymb...

  14. 32 CFR 256.8 - Land use compatibility guidelines for accident potential.

    Science.gov (United States)

    2010-07-01

    ... Yes. Personal and business services: 5 Finance, insurance and real estate ......do ......do Do. Personal services ......do ......do Do. Business services ......do ......do Do. Repair services ......do... 4170.7, “Natural Resources—Forest Management,” June 21, 1965 (32 CFR 233) and DoD Instruction...

  15. Towards Primary School Physics Teaching and Learning: Design Research Approach. Research Report 256

    Science.gov (United States)

    Juuti, Kalle

    2005-01-01

    This thesis describes a project to design a primary school physics learning environment which takes into account teachers' needs, design procedures, properties of the learning environment, and pupil learning outcomes. The project's design team has wide experience in research and development work in relation to science education, the use of ICT in…

  16. 40 CFR 256.31 - Recommendations for developing and implementing resource conservation and recovery programs.

    Science.gov (United States)

    2010-07-01

    ... requirement. (4) Development of a strategy for the consideration of the legislature to prohibit and/or remove...; and (4) Development of a strategy and plan of action for the consideration of the legislature for... requirements, pricing mechanisms and long-term contract availability. (3) Resource recovery feasibility...

  17. The Walker 256 Breast Cancer Cell- Induced Bone Pain Model in Rats

    OpenAIRE

    Priyank Ashok Shenoy; Andy Kuo; Irina Vetter; Maree Therese Smith

    2016-01-01

    The majority of patients with terminal breast cancer show signs of bone metastasis, the most common cause of pain in cancer. Clinically available drug treatment options for the relief of cancer-associated bone pain are limited due to either inadequate pain relief and/or dose-limiting side-effects. One of the major hurdles in understanding the mechanism by which breast cancer causes pain after metastasis to the bones is the lack of suitable preclinical models. Until the late twentieth century,...

  18. 37 CFR 256.2 - Royalty fee for compulsory license for secondary transmission by cable systems.

    Science.gov (United States)

    2010-07-01

    ... section, 3.75 per centum of the gross receipts of the cable systems for each distant signal equivalent... market, (i) .599 per centum of such gross receipts for the first distant signal equivalent; (ii) .377 per... additional distant signal equivalent thereafter; (2) For cable systems located wholly or in part within...

  19. 30 CFR 256.90 - Which leases may I exchange for a bonus or royalty credit?

    Science.gov (United States)

    2010-07-01

    ... coastline of the State of Florida, or (2) The Central planning area and within the Desoto Canyon OPD, the Destin Dome OPD, or the Pensacola OPD, and within 100 miles of the coastline of the State of Florida....

  20. Experimental Study of Nonlinear Phase Noise and its Impact on WDM Systems with DP-256QAM

    DEFF Research Database (Denmark)

    Yankov, Metodi Plamenov; Da Ros, Francesco; Porto da Silva, Edson

    2016-01-01

    A probabilistic method for mitigating the phase noise component of the non-linear interference in WDM systems with Raman amplification is experimentally demonstrated. The achieved gains increase with distance and are comparable to the gains of single-channel digital back-propagation....

  1. 78 FR 62329 - Special Local Regulation; Tennessee River, Miles 255.0 to 256.5, Florence, AL

    Science.gov (United States)

    2013-10-17

    ... assessment of potential costs and benefits under section 6(a)(3) of Executive Order 12866 or under section 1...'' comprises small businesses, not-for-profit organizations that are independently owned and operated and are not dominant in their fields, and governmental jurisdictions with populations of less than 50,000....

  2. 2-(5,6-Dibromo-7-methyl-3H-imidazo[4,5-b]pyridin-2-ylphenol

    Directory of Open Access Journals (Sweden)

    Haixia Wang

    2010-12-01

    Full Text Available In the title compound, C13H9Br2N3O, the molecular skeleton, influenced by an intramolecular O—H...N hydrogen bond, is roughly planar, with a mean deviation of 0.033 Å. In the crystal, intermolecular N—H...O hydrogen bonds link the molecules into chains propagating in [100]. Weak intermolecular π–π interactions [centroid–centroid distances = 3.760 (3 and 3.723 (3 Å] further consolidate the packing.

  3. 256-Slice coronary computed tomographic angiography in patients with atrial fibrillation: optimal reconstruction phase and image quality

    Energy Technology Data Exchange (ETDEWEB)

    Oda, Seitaro; Yuki, Hideaki; Kidoh, Masafumi; Utsunomiya, Daisuke; Nakaura, Takeshi; Namimoto, Tomohiro; Yamashita, Yasuyuki [Kumamoto University, Department of Diagnostic Radiology, Faculty of Life Sciences, Chuou-ku, Kumamoto (Japan); Honda, Keiichi; Yoshimura, Akira; Katahira, Kazuhiro [Kumamoto Chuo Hospital, Department of Diagnostic Radiology, Minami-ku, Kumamoto (Japan); Noda, Katsuo; Oshima, Shuichi [Kumamoto Chuo Hospital, Department of Cardiology, Minami-ku, Kumamoto (Japan)

    2016-01-15

    To assess the optimal reconstruction phase and the image quality of coronary computed tomographic angiography (CCTA) in patients with atrial fibrillation (AF). We performed CCTA in 60 patients with AF and 60 controls with sinus rhythm. The images were reconstructed in multiple phases in all parts of the cardiac cycle, and the optimal reconstruction phase with the fewest motion artefacts was identified. The coronary artery segments were visually evaluated to investigate their assessability. In 46 (76.7 %) patients, the optimal reconstruction phase was end-diastole, whereas in 6 (10.0 %) patients it was end-systole or mid-diastole, and in 2 (3.3 %) patients it was another cardiac phase. In 53 (88.3 %) of the controls, the optimal reconstruction phase was mid-diastole, whereas it was end-systole in 4 (6.7 %), and in 3 (5.0 %) it was another cardiac phase. There was a significant difference between patients with AF and the controls in the optimal phase (p < 0.01) but not in the visual image quality score (p = 0.06). The optimal reconstruction phase in most patients with AF was the end-diastolic phase. The end-systolic phase tended to be optimal in AF patients with higher average heart rates. (orig.)

  4. Prospective ECG triggering reduces prosthetic heart valve-induced artefacts compared with retrospective ECG gating on 256-slice CT.

    NARCIS (Netherlands)

    Symersky, P.; Habets, J.; Westers, P.; Mol, B.A. de; Prokop, M.; Budde, R.P.

    2012-01-01

    OBJECTIVES: Multidetector computed tomography (MDCT) has diagnostic value for the evaluation of prosthetic heart valve (PHV) dysfunction but it is hampered by artefacts. We hypothesised that image acquisition using prospective triggering instead of retrospective gating would reduce artefacts related

  5. Thermal and physical property determination for IONSIV/256 IE-911 crystalline silicotitanate and Savannah River Site waste simulant solutions

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-12-08

    This document describes physical and thermophysical property determinations that were made in order to resolve questions associated with the decontamination of Savannah River Site waste streams using ion exchange on crystalline silicotitanate.

  6. Patrick Charaudeau. — Le discours politique. Les masques du pouvoir. Paris : Vuibert, 256 pages (23 €).

    OpenAIRE

    De Chanay, Hugues

    2006-01-01

    À partir d’une analyse de portée générale du discours politique en tant que tel (dont l’auteur s’efforce de préciser théoriquement la nature, les fonctions, les contraintes, les procédés), c’est à la fois à une réflexion sur la construction des identités, tant individuelles que collectives, et à un diagnostic prudent sur l’évolution de la médiation politique – indispensable à la cohésion minimale du « vivre ensemble » qui fait la société – dans le monde contemporain (occidental essentiellemen...

  7. Hadron Spectrum in QCD with Valence Wilson Fermions and Dynamical Staggered Fermions at $6/g^2=5.6$

    CERN Document Server

    Bitar, K M; Edwards, R G; Gottlieb, S; Heller, U M; Kennedy, A D; Kogut, J B; Krasnitz, A; Liu, W; Ogilvie, M C; Renken, R L; Rossi, P; Sinclair, D K; Sugar, R L; Toussaint, D; Wang, K C

    1992-01-01

    We present an analysis of hadronic spectroscopy for Wilson valence quarks with dynamical staggered fermions at lattice coupling $6/g^2 = \\beta=5.6$ at sea quark mass $am_q=0.01$ and 0.025, and of Wilson valence quarks in quenched approximation at $\\beta=5.85$ and 5.95, both on $16^3 \\times 32$ lattices. We make comparisons with our previous results with dynamical staggered fermions at the same parameter values but on $16^4$ lattices doubled in the temporal direction.

  8. 256 Shades of Grey: Dating young lava flows using high-resolution sidescan imagery from the Kolbeinsey Ridge

    Science.gov (United States)

    Yeo, I. A.; Rothenbeck, M.; Devey, C. W.

    2013-12-01

    We present high-resolution (1 m) sidescan data from the slow-spreading (1.8 cm/yr) Kolbeinsey Ridge between 71°45'N and 70°30'N collected using an Edgetech 2200-MP 120 kHz sidescan sonar. Comparing the sound intensity between flat, heavily sedimented, off-axis areas and flat, brightly reflective, on-axis lava flows yields a difference of 20 - 30 dB and therefore a detection depth for basaltic lava flows of 30 - 60 cm of sediment burial at a grazing angle of 30 degrees. The single sensor does not allow for the extraction of phase bathymetry from the sidescan, however hummocks covered by the surveys were characterized by relatively flat summits (as seen in profiles extracted from the AUV depth and altitude measurements), and so summit regions could be considered comparable to flatter areas of seafloor. As volcanic hummocks are likely to be monogenetic edifices, sediment thicknesses extracted for the summits should be equivalent to those for the whole edifice. Using only flat areas also removes the problems of sediment slumping downslope. Ground truthing of actual sediment thicknesses will be carried out on cruises in November/December 2013 and September/October 2014 and will open up the potential for in-cruise estimation of the actual ages of young volcanic features covered by sidescan surveys, where good estimates of sedimentation rates are available.

  9. Implementing a benchmarking and feedback concept decreases postoperative pain after total knee arthroplasty: A prospective study including 256 patients

    Science.gov (United States)

    Benditz, A.; Drescher, J.; Greimel, F.; Zeman, F.; Grifka, J.; Meißner, W.; Völlner, F.

    2016-01-01

    Perioperative pain reduction, particularly during the first two days, is highly important for patients after total knee arthroplasty (TKA). Problems are not only caused by medical issues but by organization and hospital structure. The present study shows how the quality of pain management can be increased by implementing a standardized pain concept and simple, consistent benchmarking. All patients included into the study had undergone total knee arthroplasty. Outcome parameters were analyzed by means of a questionnaire on the first postoperative day. A multidisciplinary team implemented a regular procedure of data analyzes and external benchmarking by participating in a nationwide quality improvement project. At the beginning of the study, our hospital ranked 16th in terms of activity-related pain and 9th in patient satisfaction among 47 anonymized hospitals participating in the benchmarking project. At the end of the study, we had improved to 1st activity-related pain and to 2nd in patient satisfaction. Although benchmarking started and finished with the same standardized pain management concept, results were initially pure. Beside pharmacological treatment, interdisciplinary teamwork and benchmarking with direct feedback mechanisms are also very important for decreasing postoperative pain and for increasing patient satisfaction after TKA. PMID:27917911

  10. Response to "Comment on ‘Electric Multipole Moments for Some First-Row Diatomic Hydride Molecules' [Commun. Theor. Phys. 38 (2002) 256]"

    Institute of Scientific and Technical Information of China (English)

    Metin Orbay; Telhat Ozdogan

    2003-01-01

    The comment of Guseinov is irrelevant and also unjust. In contrast to his comment, we show that theobtained electric multipole moment values for some first-row diatomic molecules are original and better than his values(I.I. Guseinov, E. Akin, and A.M. Rzaeva, J. Mol. Struct. (Theochem) 453 (1998) 163) with respect to Hartree-Fockvalues. Moreover, it must be noted that all the formulas are cited in our paper (M. Orbay and T. Ozdogan, Commun.Theor. Phys. (Beijing, China) 35 (2001) 585) and corrigendum (M. Orbay and T. Ozdogan, Commun. Theor. Phys.(Beijing, China) 37 (2002) 768).

  11. Measurement of isolated myocyte volume using the Coulter models Z2 and ZM/C256: a comparison of instrument function.

    Science.gov (United States)

    Said, S; Tamura, T; Gerdes, A M

    1998-09-01

    Changes in cardiac structure that depart from normal have generally been termed "remodeling". Assessment of ventricular remodeling at the cellular level should include measurement of myocyte dimensions. A well-established and reliable method to assess myocyte remodeling uses isolated cells and the Coulter Counter/Channelyzer system. The new Coulter Model Z2 has numerous modifications and improvements from the Model Z predecessor(s) interfaced to a pulse-height analyzer (e.g., channelyzer). Improvements of the Model Z2 over older instruments include: (i) elimination of the mercury manometer with accompanying oil-displacement pump; (ii) reduced size and weight; (iii) a higher degree of mechanization and automation; (iv) inclusion of an advanced comprehensive statistical package and (v) a substantial reduction in cost. The purpose of this study was to determine if the newly modified instrument produces the same results as the previous instrument combinations, which were shown to produce reliable cell volume data from irregularly shaped cells such as cardiac myocytes.

  12. Identifying plant species using mid-wave infrared (2.5-6µm) and thermal infrared (8-14µm) emissivity spectra

    NARCIS (Netherlands)

    Ullah, S.; Schlerf, M.; Skidmore, A.K.; Hecker, C.

    2012-01-01

    Plant species discrimination using remote sensing is generally limited by the similarity of their reflectance spectra in the visible, NIR and SWIR domains. Laboratory measured emissivity spectra in the mid infrared (MIR; 2.5µm-6µm) and the thermal infrared (TIR; 8µm-14µm) domain of different plant s

  13. Crystal structure of hexaaquanickel(II bis{2-[(5,6-dihydroxy-3-sulfonatoquinolin-1-ium-7-yloxy]acetate} dihydrate

    Directory of Open Access Journals (Sweden)

    Hai Le Thi Hong

    2015-09-01

    Full Text Available The asymmetric unit of the title compound, [Ni(H2O6](C11H8NO8S2·2H2O, features a half-hexaaquanickel(II complex cation with the NiII ion on an inversion center, one deprotonated 5,6-dihydroxy-3-sulfoquinolin-7-yloxyacetic acid (QOH molecule appearing in its zwitterionic form and one lattice water molecule. The sulfonate group is disordered over two positions with occupancy factors of 0.655 (5 and 0.345 (5. The hexaaquanickel(II cation interacts through hydrogen bonding with eight QOH molecules and two water molecules. The six-membered rings of quinoline show π–π stacking [centroid-to-centroid distances of 3.679 (2 Å and 3.714 (2 Å].

  14. Wilderness record, Semidi wilderness proposal involving Semidi Island (256,422) acres in the Semidi National Wildlife Refuge, Third Judicial District, Alaska

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Wilderness study report; mineral appraisal; refuge objective statement; Federal Register notice; materials sent to news media; and public hearing package, mailing...

  15. Efraín Kristal. Temptation of the Word. The Novels of Mario Vargas Llosa. Nashville: Vanderbilt University Press, 1998. 256 pp

    Directory of Open Access Journals (Sweden)

    Cecilia Esparza

    2013-09-01

    Full Text Available El estudio de Efraín Kiistal sobre las novelas de Mario VargasLlosa se centra en el análisis del proceso creativo del autor, en losdiálogos que entabla con otros trabajos literarios y en la transformaciónde la experiencia vital en sus textos ficcionales.

  16. 78 FR 21567 - Installation of Radiation Alarms for Rooms Housing Neutron Sources

    Science.gov (United States)

    2013-04-11

    ... californium-252 (Cf-252). A licensee's decision to use a specific type of source may depend upon cost, availability, and the dependence upon historical data with which to compare current measurement results. The...

  17. 256排螺旋CT灌注成像对肝细胞型肝癌与局灶性结节增生的鉴别诊断价值%The Differential Diagnosis Value of 256 Slices Spiral CT Perfusion Imaging in Hepatocellular Carcinoma and Focal Nodular Hyperplasia

    Institute of Scientific and Technical Information of China (English)

    李靖翊; 刘建滨; 史凤霞; 谢安

    2014-01-01

    目的:探讨CT灌注成像对肝细胞型肝癌(HCC)与局灶性结节增生(FNH)的鉴别诊断价值。方法比较14例HCC(A组)、10例FNH(B组)的实性成分的CT灌注值;比较FNH实性成分与远处肝组织CT灌注值;比较HCC实性成分、灶周组织及远处肝组织的CT灌注值。结果 A组的实性部分肝动脉灌注量(hepatic arterial perfusion,HAP)、总肝灌注量(total liver perfusion,TLP)、肝动脉灌注指数(hepatic artery perfusion index, HPI)都低于B组,门静脉灌注量(portal venous perfusion,PVP)高于B组,其中HAP、PVP及HPI存在统计学差异。A组病灶实性部分的HAP、HPI高于灶周、远处肝组织,并存在统计学意义;病灶实性部分的PVP低于灶周、远处肝组织,存在统计学差异。B组中病灶实性部分的HAP、HPI、TLP高于远处肝组织,PVP低于远处肝组织,其中HAP、HPI及PVP存在统计学差异。结论 CT灌注成像对肝癌及局灶性结节增生的诊断及鉴别诊断具有重要临床意义。%Objective To investigate the differential diagnosis value of CT perfusion imaging in hepatocellular carcinoma(HCC) and focal nodular hyperplasia(FNH). Methods Comparison of 14 cases of HCC (group A) and 10 cases of FNH (group B) CT perfusion value of solid part; Comparison of FNH of solid composition and the distant liver tissue CT perfusion value; Comparison of HCC solid component, Lesions surrounding tissue and distant liver tissue CT perfusion value. Results The group A solid part of the hepatic artery perfusion (HAP), the total amount of liver perfusion (TLP), hepatic artery perfusion index (HPI) is lower than that of group B, portal venous perfusion (PVP) higher than that of group B, the HAP, PVP and HPI statistical differences. Group A solid lesions component of HAP, HPI above focal weeks, liver tissue in the distance, and there is statistical significance; Solid lesions component of PVP below focal weeks, distant liver tissue, statistical differences. Solid lesions in group B component of HAP, the HPI, TLP is higher than the distant liver tissue, PVP is lower than the distant liver tissue, HAP, HPI and PVP statistical differences among them. Conclusion CT perfusion imaging of HCC and FNH of the diagnosis and differential diagnosis has important clinical significance.

  18. 256层螺旋CT全肝灌注成像对正常肝脏血流状态的评价研究%Evaluation of the blood flow in normal liver by 256 Slices MSCT whole liver perfusion imaging

    Institute of Scientific and Technical Information of China (English)

    高知玲; 李梦迪; 朱凯; 陈勇

    2015-01-01

    目的 通过多层螺旋CT全肝灌注模式,探讨正常肝脏各段血流状态.方法 选择胃癌患者43例,男28例,女15例;年龄35~ 81岁,中位年龄为55.6岁;应用多层螺旋CT(MSCT)进行全肝灌注增强扫描,并分别测定肝脏各段灌注参数值,包括动脉灌注量(HAP)、门静脉灌注量(PVP)、总肝灌注量(TLP)和肝动脉灌注指数(HPI),以评价正常肝脏各段的血流动力学状态.结果 正常肝脏S3段HAP与S6、S7、S8以及S4与S7段差异均有统计学意义(P<0.05),S3段HPI与S7段差异亦有统计学意义(P<0.05).不同性别正常肝脏Couinaud 8段之间灌注参数值差异无统计学意义.结论 正常肝脏部分肝段之间血流存在差异,多螺旋CT全肝脏灌注成像能更全面地评价肝脏的血流状态.

  19. A new shipping container for an intense neutron emitter

    Energy Technology Data Exchange (ETDEWEB)

    Bigelow, J.E.; Alexander, C.W.; Pace, J.V. III; Simmons, C.M.

    1994-06-01

    Californium-252 is an intense neutron emitter (2.34 {times} 10{sup 12} n/s{center_dot}g) used in medicine, research, and industry. The western world`s sole source of this rare radioisotope is the Californium Facility at Oak Ridge National Laboratory`s Radiochemical Engineering Development Center (REDC). A project has been initiated at the REDC to design a new Type B Californium Shipping Container. This effort is essential for future transportation of californium to meet the needs of users all over the world. The shipping container must meet all requirements for transport by motor freight, air, vessel, and rail, both domestic and foreign. There are unique problems in the design, fabrication, and licensing of a new Type B shipping container that will accommodate up to 60 milligrams of californium-252. One of the first challenges in the design phase of the project is the selection of a material to shield the high neutron flux. The more stringent safety precautions of today`s world impel us to consider more exotic materials for such a purpose. The candidate materials must be examined not just for their neutron shielding properties, but also in conjunction with other properties such as thermal and structural requirements to withstand the hypothetical accident conditions. The design and building of such a container is a formidable task requiring much planning. The licensing process, with the complex, interactive federal codes, is a special challenge and may be the biggest on the project in terms of time and money.

  20. SU-E-J-256: Predicting Metastasis-Free Survival of Rectal Cancer Patients Treated with Neoadjuvant Chemo-Radiotherapy by Data-Mining of CT Texture Features of Primary Lesions

    Energy Technology Data Exchange (ETDEWEB)

    Zhong, H; Wang, J; Shen, L; Hu, W; Wan, J; Zhou, Z; Zhang, Z [Fudan University Shanghai Cancer Center, Shanghai (China)

    2015-06-15

    Purpose: The purpose of this study is to investigate the relationship between computed tomographic (CT) texture features of primary lesions and metastasis-free survival for rectal cancer patients; and to develop a datamining prediction model using texture features. Methods: A total of 220 rectal cancer patients treated with neoadjuvant chemo-radiotherapy (CRT) were enrolled in this study. All patients underwent CT scans before CRT. The primary lesions on the CT images were delineated by two experienced oncologists. The CT images were filtered by Laplacian of Gaussian (LoG) filters with different filter values (1.0–2.5: from fine to coarse). Both filtered and unfiltered images were analyzed using Gray-level Co-occurrence Matrix (GLCM) texture analysis with different directions (transversal, sagittal, and coronal). Totally, 270 texture features with different species, directions and filter values were extracted. Texture features were examined with Student’s t-test for selecting predictive features. Principal Component Analysis (PCA) was performed upon the selected features to reduce the feature collinearity. Artificial neural network (ANN) and logistic regression were applied to establish metastasis prediction models. Results: Forty-six of 220 patients developed metastasis with a follow-up time of more than 2 years. Sixtyseven texture features were significantly different in t-test (p<0.05) between patients with and without metastasis, and 12 of them were extremely significant (p<0.001). The Area-under-the-curve (AUC) of ANN was 0.72, and the concordance index (CI) of logistic regression was 0.71. The predictability of ANN was slightly better than logistic regression. Conclusion: CT texture features of primary lesions are related to metastasisfree survival of rectal cancer patients. Both ANN and logistic regression based models can be developed for prediction.

  1. Cooperation of invariant NKT cells and CD46+CD256+ T regulatory cells in prevention of autoimmune diabetes in non-obese diabetic mice treated with α-galactosylceramide

    Institute of Scientific and Technical Information of China (English)

    Weipeng Li; Fang Ji; Yong Zhang; Ying Wang; Neng yang; Hailiang Ge; Fuqing Wang

    2008-01-01

    CD1d-restricted natural killer T (NKT) cells and CD4+CD25+regulatory T (Treg) cells are two thymus-derived subsets of regulatory T cells that play an important role in the maintenance of self-tolerance. Yet the functional changes of the two subsets of regulatory T cells in the development of diabetes in non-obese diabetic (NOD) mice remain unclear, and how NKT cells and CD4+CD25+ Treg cells cooperate functionally in the regulation of autoimmune diabetes is also uncertain.We provide evidence that in NOD mice, an animal model of human type 1 diabetes, the functions of both NKT cells and CD4+CD25+ Treg cells decrease in an age-dependent manner.We show that treatment with α-galactosylceramide increases the size of the CD4+CD25+ Treg cell compartment in NOD mice, and augments the expression of forkhead/winged helix transcription factor and the potency of CD4+CD25+ Treg cells to inhibit proliferation of CD4+CD25- T cells. Our data indicate that NKT cells and CD4+CD25+ Treg cells might cooperate in the prevention of autoimmune diabetes in NOD mice treated with α-galactosylceramide. Induced cooperation of NKT cells and CD4+CD25+ Treg cells could serve as a strategy to treat human autoimmune disease, such as type 1 diabetes.

  2. A PERCEPÇÃO DA INCERTEZA E O DESEMPENHO OPERACIONAL DA INDÚSTRIA BRASILEIRA DE 2007 A 2009 DOI:10.7444/fsrj.v2i2.56

    OpenAIRE

    Marta Sambiase Lombardi; Caio Eduardo Bertoni; Guilherme Issamu Nozawa; Leandro Augustto Grandi; Thiago Bellato

    2010-01-01

    This article poses to explore the relationship between the manager´s perception of uncertainty and the Brazilian industry´s operational performance during the period from 2007 to 2009. This timeframe was chosen because it comprised both positive and negative cycles of the global economic panorama, and thus capable of interfering in the manager´s perception of uncertainty and consequent business strategies. Periods of market fluctuations and more dynamic and complex business environments clear...

  3. Crystal structure of hexa-aqua-nickel(II) bis{2-[(5,6-di-hy-droxy-3-sul-fon-ato-quino-lin-1-ium-7-yl)oxy]acetate} dihydrate.

    Science.gov (United States)

    Le Thi Hong, Hai; Nguyen Thi Ngoc, Vinh; Tran Thi, Da; Nguyen Bich, Ngan; Van Meervelt, Luc

    2015-09-01

    The asymmetric unit of the title compound, [Ni(H2O)6](C11H8NO8S)2·2H2O, features a half-hexa-aqua-nickel(II) complex cation with the Ni(II) ion on an inversion center, one deprotonated 5,6-dihy-droxy-3-sulfoquinolin-7-yloxyacetic acid (QOH) molecule appearing in its zwitterionic form and one lattice water mol-ecule. The sulfonate group is disordered over two positions with occupancy factors of 0.655 (5) and 0.345 (5). The hexa-aqua-nickel(II) cation inter-acts through hydrogen bonding with eight QOH mol-ecules and two water mol-ecules. The six-membered rings of quinoline show π-π stacking [centroid-to-centroid distances of 3.679 (2) Å and 3.714 (2) Å].

  4. La generación app (The App Generation) : Autores: Howard Gardner y Katie Davis. Editorial: Paidos. Año 2014 - 256 paginas. Idioma: Español. ISBN: 978-84-493-2985-2

    OpenAIRE

    Luque, Mónica

    2014-01-01

    La reciente publicación de Gardner, en colaboración con Katie Davis, propone una interesante línea de indagación y reflexión en torno a las jóvenes generaciones. En primer término, lo particular de este grupo etario consiste en que son los únicos que no han conocido un mundo sin la ubicuidad que ofrecen los medio digitales. Por tanto, Gardner indica que las apps están modificando el desarrollo psicológico de los jóvenes, quienes tienden actualmente a ser más renuentes al riesgo que las genera...

  5. Multibeam collection for TN256: Multibeam data collected aboard Thomas G. Thompson from 2010-10-23 to 2010-11-03, departing from Seattle, WA and returning to Seattle, WA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  6. Discovery of Isotopes of the Transuranium Elements with 93 <= Z <= 98

    CERN Document Server

    Fry, C

    2012-01-01

    One hundred and five isotopes of the transuranium elements neptunium, plutonium, americium, curium, berkelium and californium have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  7. Analysis and Performance Evaluation of Electrocardiogram Data compression Techniques.

    Science.gov (United States)

    1980-12-01

    7, - 04290 0,1, 1-0 ("’C4 I A ?APC(-CL- PT C, 0431f, 04’ P6 03C C-I ISO C77 C 04320 04C’ -on T1 di ) 043 O 481𔃼> 1-1 ) 0 1*ji1 JC 1, ~ P, 1’ "’ W...1120 DIGITS= 4 1130 L7=6 1140 M4=PEEK(13483)+PEEK(13482)*256+PEEK(134EI)*256*256 1150 D4=PEEK(13487)+PEEK(13486)*256+PEEK( 13485 )*256*256 1160 D4=PEEI

  8. Results of Near Field Probe Scanning Tests for Ultralow Sidelobe Arrays

    Science.gov (United States)

    1986-05-01

    FILE? - Y/N N ROW - 256 COLUMN - 128 ANPC - 0.0019 PHSC- -112.7022 ANPX- 0.2125 PHSX - -176.670 ROW - 256 COLUMN - 129 AMPC - 0.0017 PHSC- -80.3665 AMPX...0.2143 PHSX - -176.955 * ROW-- 256 COLUMN -130 AMPC - 0.0014 PHSC- -47.i0944 AMPX- 0.2160 PHSX - -177.479- ROW - 256 COLUMN 131 AMPC -*0.0020 PHSC...22.1320 ANPXa 0.2179 PHSX - ;-177.015 ROW - 256 COLUMN - 132 AMPC - 0.0026 PHSC- -2.0839 AMPX- 0.2197 PHSX - -176.580 ROW - 256 COLUMN - 133 ANPC

  9. Measurement of the energy spectra of fission fragments using nuclear track detectors and digital image processing

    Energy Technology Data Exchange (ETDEWEB)

    Espinosa, Guillermo; Golzarri, Jose I. [Instituto de Fisica, Universidad Nacional Autonoma de Mexico, A.P. 20-364, Mexico D.F. 01000 (Mexico); Castano, Victor M., E-mail: castano@fata.unam.m [Centro de Fisica Aplicada y Tecnologia Avanzada, Universidad Nacional Autonoma de Mexico, Boulevard Juriquilla 3001, Santiago de Queretaro, Queretaro 76230 (Mexico)

    2010-08-15

    Energy spectra of fission fragments were determined using a Nuclear Track Methodology (NTM) supported by digital image analysis and numerical data processing using a standard personal computer. The analysis of a californium ({sup 252}Cf) spectrum with this approach shows improvement compared with the values reported previously using the standard procedure, in terms of resolution and accuracy. This new method adds full automation to the technical advantages and cost effectiveness of an NTM.

  10. Latte-Abdallah Stéphanie et Parizot Cédric (dir., À l'ombre du mur. Israéliens et Palestiniens entre séparation et occupation, Actes Sud/MMSH, 2011, 368 p.Barthe Benjamin, Ramallah Dream. Voyage au cœur du mirage palestinien, Paris, La Découverte, 2011, 256 p.

    Directory of Open Access Journals (Sweden)

    Jean-François Legrain

    2012-12-01

    Full Text Available En ces temps où le conflit israélo-palestinien ne suscite qu’un intérêt des plus limités parmi les politiques et les médias, la lecture de ces deux ouvrages, éminemment complémentaires, continue à s’imposer plus d’un an après leur parution. Si le premier, en effet, est l’œuvre d’universitaires français, palestiniens et israéliens quand le second a été écrit par un journaliste au Monde, tous deux sont le fruit d’une réflexion menée à partir d’une profonde expérience de terrain. Plus fondamenta...

  11. Pablo Rodríguez Jiménez. Cartas de Amor en tiempos de guerra. Rafael Uribe Uribe. Selección de textos y prólogo. Bogotá: Editorial Universidad del Rosario, Escuela de Ciencias Humanas, 2014. 256 páginas

    Directory of Open Access Journals (Sweden)

    Eulalia Hernández Ciro

    2015-07-01

    Full Text Available Conversar por escrito es lo que hacía Rafael Uribe Uribe con su esposa, Sixta Tulia Gaviria, a través de las cartas, retratos, telegramas y cables que intercambiaron durante varios años y que hoy podemos leer de corrido, gracias al libro Cartas de amor en tiempos de guerra..., compilado por el historiador Pablo Rodríguez Jiménez y publicado en el 2014 por la Editorial de la Universidad del Rosario, que agrupa conversas que, además de su riqueza literaria, son valioso material para la comprensión de la historia de nuestro país, no solo porque muestran el lado sensible y cotidiano de la vida de un hombre que ocupa un lugar privilegiado en la historia de Colombia, sino porque dejan entrever los discursos, las representaciones y las prácticas de la clase dirigente del país. Acercarse a esta correspondencia posibilita conocer asuntos concernientes a los roles femeninos y masculinos, a la educación de los hijos, a las relaciones sociales y públicas, a la vida doméstica, es decir, tanto las ideas y los sentimientos, como la geografía y la cultura material de una época.

  12. 47 CFR 76.1909 - Redistribution control of unencrypted digital terrestrial broadcast content.

    Science.gov (United States)

    2010-10-01

    ... of the 8-VSB, 16-VSB, 64-QAM or 256-QAM signal, inspect either the EIT or PMT for the broadcast flag...; and (2) Use 8-VSB, 16-VSB, 64-QAM, or 256-QAM signal modulation for the retransmission. (d)...

  13. Novel Single Photon Counting Readout Circuits and APD Arrays with Capability from UV to IR Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The overall goal of the proposed Phase I SBIR project is to develop and demonstrate 256x256 segmented readout integrated circuits (ROICs) that can read, digitize and...

  14. NCBI nr-aa BLAST: CBRC-BTAU-01-2827 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available tical protein bbp_256 [Buchnera aphidicola str. Bp (Baizongia pistaciae)] NP_777878.1 3e-04 27% ... ...CBRC-BTAU-01-2827 ref|NP_777878.1| hypothetical protein bbp256 [Buchnera aphidicola str. Bp (Baizongia pista...ciae)] sp|Q89AL2|Y256_BUCBP UPF0259 membrane protein bbp_256 gb|AAO26983.1| hypothe

  15. DOD Product Support Business Case Analysis Guidebook

    Science.gov (United States)

    2011-04-01

    Cargo Aircraft; Mike Tesi , 256-313-3745 10 Automatic Requirements Computation System Initial Provisioning (ARCSIP) CECOM; Ken Steinberg, LEO...Block III 256-313- 4988 PM Aviation Systems, PD Joint Cargo Aircraft Mike Tesi , 256- 313-3745 16 Computerized Optimization Model for

  16. TOWARD AN IMPROVED UNDERSTANDING OF STRUCTURE AND MAGNETISM IN NEPTUNIUM AND PLUTONIUM PHOSPHONATES AND SULFONATES

    Energy Technology Data Exchange (ETDEWEB)

    Albrecht-Schmitt, Thomas

    2012-03-01

    This grant supported the exploratory synthesis of new actinide materials with all of the actinides from thorium to californium with the exceptions of protactinium and berkelium. We developed detailed structure-property relationships that allowed for the identification of novel materials with selective ion-exchange, selective oxidation, and long-range magnetic ordering. We found novel bonding motifs and identified periodic trends across the actinide series. We identified structural building units that would lead to desired structural features and novel topologies. We also characterized many different spectroscopic trends across the actinide series. The grant support the preparation of approximately 1200 new compounds all of which were structurally characterized.

  17. Detection of rare earth elements in Powder River Basin sub-bituminous coal ash using laser-induced breakdown spectroscopy (LIBS)

    Energy Technology Data Exchange (ETDEWEB)

    Tran, Phuoc [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State; Mcintyre, Dustin [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State

    2015-10-01

    We reported our preliminary results on the use of laser-induced breakdown spectroscopy to analyze the rare earth elements contained in ash samples from Powder River Basin sub-bituminous coal (PRB-coal). We have identified many elements in the lanthanide series (cerium, europium, holmium, lanthanum, lutetium, praseodymium, promethium, samarium, terbium, ytterbium) and some elements in the actinide series (actinium, thorium, uranium, plutonium, berkelium, californium) in the ash samples. In addition, various metals were also seen to present in the ash samples

  18. NONDESTRUCTIVE IDENTIFICATION OF CHEMICAL WARFARE AGENTS AND EXPLOSIVES BY NEUTRON GENERATOR-DRIVEN PGNAA

    Energy Technology Data Exchange (ETDEWEB)

    T. R. Twomey; A. J. Caffrey; D. L. Chichester

    2007-02-01

    Prompt gamma-ray neutron activation analysis (PGNAA) is now a proven method for the identification of chemical warfare agents and explosives in military projectiles and storage containers. Idaho National Laboratory is developing a next-generation PGNAA instrument based on the new Ortec Detective mechanically-cooled HPGe detector and a neutron generator. In this paper we review PGNAA analysis of suspect chemical warfare munitions, and we discuss the advantages and disadvantages of replacing the californium-252 radioisotopic neutron source with a compact accelerator neutron generator.

  19. An ECR Charge Breeder for the 252 Cf Fission Source Project (CARIBU) at ATLAS%ATLAS用于CARIBU项目的ECR离子剥离器

    Institute of Scientific and Technical Information of China (English)

    R.C.Pardo; R.Vondrasek; T.Kulevoy; V.Aseev; R.Scott; P.Suominen

    2007-01-01

    A new radioactive beam facility for ATLAS,the Californium Rare Ion Breeder Upgrade(CARIBU),is under construction.The facility will use fission fragments from a 1 Ci 252 Cf source;thermalized and collected into a low-energy beam by a helium gas catcher.In order to reaccelerate these beams.the existing ATLAS ECR-I ion source is being redesigned to function as a charge breeder source.The design and features of this charge breeder configuration is discussed and the project status described.

  20. Advanced development of the spectrum sciences Model 5005-TF, single-event test fixture

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, M.R.; Browning, J.S. (Sandia National Labs., Albuquerque, NM (USA)); Hughlock, B.W. (Boeing Aerospace and Electronics Co., Seattle, WA (USA)); Lum, G.K. (Lockheed Missiles and Space Co., Sunnyvale, CA (USA)); Tsacoyeanes, W.C. (Draper (Charles Stark) Lab., Inc., Cambridge, MA (USA)); Weeks, M.D. (Spectrum Sciences, Inc., Santa Clara, CA (USA))

    1990-09-01

    This report summarizes the advanced development of the Spectrum Sciences Model 5005-TF, Single-Event Test Fixture. The Model 5005-TF uses a Californium-252 (Cf-252) fission-fragment source to test integrated circuits and other devices for the effects of single-event phenomena. Particle identification methods commonly used in high-energy physics research and nuclear engineering have been incorporated into the Model 5005-TF for estimating the particle charge, mass, and energy parameters. All single-event phenomena observed in a device under test (DUT) are correlated with an identified fission fragment, and its linear energy transfer (LET) and range in the semiconductor material of the DUT.

  1. Method for measuring multiple scattering corrections between liquid scintillators

    Science.gov (United States)

    Verbeke, J. M.; Glenn, A. M.; Keefer, G. J.; Wurtz, R. E.

    2016-07-01

    A time-of-flight method is proposed to experimentally quantify the fractions of neutrons scattering between scintillators. An array of scintillators is characterized in terms of crosstalk with this method by measuring a californium source, for different neutron energy thresholds. The spectral information recorded by the scintillators can be used to estimate the fractions of neutrons multiple scattering. With the help of a correction to Feynman's point model theory to account for multiple scattering, these fractions can in turn improve the mass reconstruction of fissile materials under investigation.

  2. PROCEEDINGS OF THE SYMPOSIUM COMMEMORATING THE 25th ANNIVERSARY OF ELEMENTS 97 and 98 HELD ON JAN. 20, 1975

    Energy Technology Data Exchange (ETDEWEB)

    Seaborg, Glenn T.; Street Jr., Kenneth; Thompson, Stanley G.; Ghiorso, Albert

    1976-07-01

    This volume includes the talks given on January 20, 1975, at a symposium in Berkeley on the occasion of the celebration of the 25th anniversary of the discovery of berkelium and californium. Talks were given at this symposium by the four people involved in the discovery of these elements and by a number of people who have made significant contributions in the intervening years to the investigation of their nuclear and chemical properties. The papers are being published here, without editing, in the form in which they were submitted by the authors in the months following the anniversary symposium, and they reflect rather faithfully the remarks made on that occasion.

  3. Web‐Based Portal for Impact Evaluation Reveals Information Needs for Museums, Libraries and Archives. A review of: Williams, Dorothy A., Caroline Wavell, Graeme Baxter, Alan MacLennan, and Debbie Jobson. “Implementing Impact Evaluation in Professional Practice: A Study of Support Needs Within the Museum, Archive and Library Sector.” International Journal of Information Management 25.6 (Dec. 2005: 533‐48.

    Directory of Open Access Journals (Sweden)

    David Hook

    2007-03-01

    Full Text Available Objective – This study reports on research into the information and support needs of practitioners in the museum, archive, and library sectors, who are undergoing an impact evaluation.Design – Qualitative survey.Setting – Web‐based questionnaire.Subjects – Twenty‐one practitioners in the fields of museums, archives, and libraries.Methods – The study made use of a small scale web portal that provides impact evaluation research findings, toolkits, and examples of methods. The portal’s intent was to present to the users multiple views of the available information in order to overcome the problem of users not being able to identify their needs. A purposive sample group consisting of 50 practitioners from the museum, library, and archive fields was invited to participate in a questionnaire evaluating the website.Main Results – Despite a fairly low response rate (49% and poor distribution among the three sectors (museums, libraries, and archives, the results indicated a significant difference in the levels of knowledge and understanding of impact evaluation. Over half of the organizations surveyed had done some assessment of their institution’s economic impact, and there appears to be a rising trend towards doing impact studies for specific projects and developments. Nearly a quarter of the organizations had not undertaken any impact evaluation study previously. Practitioners already familiar with impact evaluation tended to look at broader range of fields for expertise, whereas those with less familiarity remained within their own sector. Practitioners with less experience preferred tools, guidance, and examples of methodologies as opposed to actual evidence of impact. The results also provided the authors with feedback on their web portal and how to organize the information therein.Conclusions – One of the findings of the study was that the overall reaction to impact evaluation support through research evidence, guidance, and other mechanisms was positive. For most practitioners, evaluation itself and the level of understanding of impact evaluation are at early stages. The primary goals for those undertaking impact evaluation were found to be professional and organizational learning, thus there is a need for practical help and guidance in these areas. Time limitation appeared to be a significant factor in the responses – particularly with smaller organizations – suggesting that their portal material would provide much‐needed assistance to such organizations. Finally, it was concluded that future emphasis should be placed on developing practical applications rather than pure research.

  4. Supercomputing:HPCMP, Performance Measures and Opportunities

    Science.gov (United States)

    2007-11-02

    28 PEs Redstone Technical Test Center (RTTC) SGI Origin 3900 24 PEs Simulations & Analysis Facility (SIMAF) Beowulf Cluster Linux...HPCMP Systems (MSRCs) HPC Center System Processors Army Research Laboratory (ARL) IBM P3 SGI Origin 3800 IBM P4 Linux Networx Cluster LNX1...Xeon Cluster IBM Opteron Cluster SGI Altix Cluster 1,280 PEs 256 PEs 512 PEs 768 PEs 128 PEs 256 PEs 2,100 PEs 2,372 PEs 256 PEs

  5. SVP-AX/CX/EX系列视频处理与变频电路解析(二)

    Institute of Scientific and Technical Information of China (English)

    周彦芳

    2011-01-01

    二、SVP-EX(256)电路 SVP—EX(256)也是Trident公司生产的一种新型视频处理与变频电路,同样采用塑料扁平封装(PQFT)形式,256脚。采用+3.3.V、+5V-1两种供电形式。

  6. The Correlation Between Subjective and Objective Measures of Coded Speech Quality and Intelligibility Following Noise Corruption

    Science.gov (United States)

    1981-12-01

    USED TO STORE C ONE BLOCK OF UNSHIFTED DATA C FROM IFILE. C JSTORE - 256 VALUE ARRAY USED TO STORE C ONE BLOCK OF SHIFTED DATA FOR C STORAGE IN JFILE...INTEGER IBLOCKSISHIFT,IFILE(13),MOVES,JFILE(13), ISTORE(256) , JSTORE (256),IER,ST(22) ,SBLK C C C ZERO OUT THE ISTORE AND JSTORE ARRAIS AT START 52 I.. C DO...10 I=1,256 ISTORE( I)=O JSTORE (I)=O 10 CONTINUE C C C ENTER THE INPUT FILENAME TO BE SHIFTED AND THE C OUTPUT FILENAME TO STORE RESULTS OF THE SHIFT

  7. Kuritegevusehirm, sotsiaalkontroll ja kommunitarism : kas kriminaalõiguse suund suuremale ühiskondlikkusele? / Jaan Sootak

    Index Scriptorium Estoniae

    Sootak, Jaan, 1948-

    2000-01-01

    Positiivsest üldpreventsioonist, ubikviteedipreventsioonist, nulltolerantsist ja kommunitaristlikust karistusteooriast. Ilmunud ka: Sootak, Jaan. Kuri karjas : [artiklite kogumik]. Tartu, 2009, lk. 225-256

  8. Improved charge breeding efficiency of light ions with an electron cyclotron resonance ion source

    Energy Technology Data Exchange (ETDEWEB)

    Vondrasek, R.; Kutsaev, Sergey [Argonne National Laboratory, Argonne, Illinois 60439 (United States); Delahaye, P.; Maunoury, L. [Grand Accelerateur National d' Ions Lourds (GANIL), CEA/DSM-CNRS/IN2P3, Blvd Henri Becquerel, 14076 Caen (France)

    2012-11-15

    The Californium Rare Isotope Breeder Upgrade is a new radioactive beam facility for the Argonne Tandem Linac Accelerator System (ATLAS). The facility utilizes a {sup 252}Cf fission source coupled with an electron cyclotron resonance ion source to provide radioactive beam species for the ATLAS experimental program. The californium fission fragment distribution provides nuclei in the mid-mass range which are difficult to extract from production targets using the isotope separation on line technique and are not well populated by low-energy fission of uranium. To date the charge breeding program has focused on optimizing these mid-mass beams, achieving high charge breeding efficiencies of both gaseous and solid species including 14.7% for the radioactive species {sup 143}Ba{sup 27+}. In an effort to better understand the charge breeding mechanism, we have recently focused on the low-mass species sodium and potassium which up to present have been difficult to charge breed efficiently. Unprecedented charge breeding efficiencies of 10.1% for {sup 23}Na{sup 7+} and 17.9% for {sup 39}K{sup 10+} were obtained injecting stable Na{sup +} and K{sup +} beams from a surface ionization source.

  9. Evaluation of the wavelet image two-line coder

    DEFF Research Database (Denmark)

    Rein, Stephan Alexander; Fitzek, Frank Hanns Paul; Gühmann, Clemens

    2015-01-01

    . The times on a low-cost microcontroller for 256×256 grayscale pictures are measured as 0.25–0.6 s for encoding and 0.22–0.77 s for decoding. The algorithm can thus realize a low complexity system for compression of images when combined with a customized scheme for the wavelet transform; low complexity here...

  10. The Impact of Assistive Technology on the Educational Performance of Students with Visual Impairments: A Synthesis of the Research

    Science.gov (United States)

    Kelly, Stacy M.; Smith, Derrick W.

    2011-01-01

    This synthesis examined the research literature from 1965 to 2009 on the assistive technology that is used by individuals with visual impairments. The authors located and reviewed 256 articles for evidence-based research on assistive technology that had a positive impact on educational performance. Of the 256 studies, only 2 provided promising…

  11. Dicty_cDB: Contig-U02923-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available , Expect = e-126 Identities = 256/256 (100%) Strand = Plus / Plus Query: 1 agaaaaaagcatcttttggtaaagaatttca...|||||||||| Sbjct: 1 agaaaaaagcatcttttggtaaagaatttcancaaaanncaataattcattgttgttatg 60 Query: 61 tttattcttttgan...Identities = 170/170 (100%) Strand = Plus / Minus Query: 1 agaaaaaagcatcttttggtaaagaatttcancaaaanncaataattca...: 586 agaaaaaagcatcttttggtaaagaatttcancaaaanncaataattcattgttgttatg 527 Query: 61 tttattcttttganncaactttctttg

  12. Converged delivery of WiMAX and wireline services over an extended reach passive optical access network

    DEFF Research Database (Denmark)

    Osadchiy, Alexey Vladimirovich; Prince, Kamau; Tafur Monroy, Idelfonso

    2010-01-01

    In this paper we present long-reach fiber access links supporting transmission of Worldwide Interoperability for Microwave Access (WiMAX) compliant signals. We present bi-directional full-duplex transmission of 256-state quadrature amplitude modulation (256-QAM) modulated WiMAX-compliant signals...

  13. Does Family Structure Matter in the Relationships between Youth Assets and Youth Alcohol, Drug and Tobacco Use?

    Science.gov (United States)

    Oman, Roy F.; Vesely, Sara K.; Tolma, Eleni; Aspy, Cheryl B.; Rodine, Sharon; Marshall, LaDonna

    2007-01-01

    This study investigated significant relationships between youth assets and youth alcohol, tobacco, and drug use that differ according to family structure (one- or two-parent households). Data were collected from a randomly sampled inner-city population (n=1,256 teenagers and 1,256 parents of the teenagers) using in-home, in-person interviews.…

  14. 78 FR 56696 - Agency Information Collection Activities

    Science.gov (United States)

    2013-09-13

    ... of the relevant labor pool in compliance with the laws enforced by the Commission and whether the... that the information collected of applicants mirror the information collected from employees on SF-256... or paralysis). The Commission concurs that the applicant flow form and the SF-256 should mirror...

  15. Equational Programming (A Study in Executable Algebraic Formal Specification).

    Science.gov (United States)

    1986-03-05

    Lecture Notes in Computer Science . Volume 86: Proceedings of the 1979 Copenhagen Winter School on Abstract Software...Dexter Kozen (editor), Lecture Notes in Computer Science . Volume 164: Proceedings, Logics of Programming Workshop, pages 221-256. Springer-Verlag...Programming Workshop, edited by Edward Clarke and Dexter Kozen, volume 164, Springer-Verlag Lecture Notes *. , in Computer Science , pages 221-256,

  16. AcEST: DK958921 [AcEST

    Lifescience Database Archive (English)

    Full Text Available se, putative;... 256 8e-67 tr|Q4PSZ5|Q4PSZ5_ARATH Putative cinnamyl-alcohol dehydrogenase O... 256 8e-67 tr|...KENNLQ 669 Query: 568 LVTINPAMVIGPLLQPTL 621 LV+INPAMVIGPLLQPTL Sbjct: 670 LVSINPAMVIGPLLQPTL 687 >tr|Q4PSZ5|Q4PS

  17. An analytical model for perpetual network codes in packet erasure channels

    DEFF Research Database (Denmark)

    Pahlevani, Peyman; Crisostomo, Sergio; Roetter, Daniel Enrique Lucani

    2016-01-01

    it with simulation results. The simulations show that for ω=5ω=5, generation size g=256g=256, and low erasure probability on the link, a destination can receive up to 70%70% overhead in average. Moreover, increasing the width, the overhead contracts, and for ω≥60ω≥60 it becomes negligible....

  18. Drug: D05341 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D05341 Drug Palmitic acid (NF) C16H32O2 256.2402 256.4241 D05341.gif Ingredient in a diagnostic aid [ultraso...und contrast medium] Same as: C00249 Component of Leovist (TN) CAS: 57-10-3 PubChem

  19. Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation in ERG11 and Exhibiting Cross-Resistance to Azoles and Amphotericin B

    NARCIS (Netherlands)

    Hull, Claire M.; Parker, Josie E.; Bader, Oliver; Weig, Michael; Gross, Uwe; Warrilow, Andrew G. S.; Kelly, Diane E.; Kelly, Steven L.

    2012-01-01

    We identified a clinical isolate of Candida glabrata (CG156) exhibiting flocculent growth and cross-resistance to fluconazole (FLC), voriconazole (VRC), and amphotericin B (AMB), with MICs of >256, >256, and 32 mu g ml(-1), respectively. Sterol analysis using gas chromatography-mass spectrometry (GC

  20. A large area position sensitive X-ray detector for astrophysical observations

    NARCIS (Netherlands)

    Mels, W.A.; Lowes, P.; Buurmans, H.B.; Brinkman, A.C.; Naber, A.P.; Rook, A.

    1988-01-01

    A large area position sensitive X-ray detector has been developed for use in the coded mask imaging X-ray spectrometer (COMIS) aboard the USSR research module KVANT. The module was launched on March 31, 1987. The detector, having a sensitive area of 256 × 256 mm2, is a sealed multiwire proportional

  1. Triton and alpha-particle contribution from LiF converter for neutron dosimeter

    CERN Document Server

    Camacho, M E; Balcazar, M

    1999-01-01

    A personnel neutron dosimeter prototype based on chemical and electrochemical etched CR-39 detector, combined with LiF converter, has been calibrated using an ICRP-like phantom, under a heavy-water moderated Californium source neutron spectra; A conversion factor of 1.052+-126 spots cm sup - sup 2 mSv sup - sup 1 was obtained. The sealing properties of the detector holder showed a ten-fold reduction in radon background when it was tested in a high radon atmosphere. A convenient mechanical shock resistance was achieved in LiF converters by sintering to 11 tons pressure LiF powder at 650 deg. C, during one hour.

  2. Reliability of semiconductor and gas-filled diodes for over-voltage protection exposed to ionizing radiation

    Directory of Open Access Journals (Sweden)

    Stanković Koviljka

    2009-01-01

    Full Text Available The wide-spread use of semiconductor and gas-filled diodes for non-linear over-voltage protection results in a variety of possible working conditions. It is therefore essential to have a thorough insight into their reliability in exploitation environments which imply exposure to ionizing radiation. The aim of this paper is to investigate the influence of irradiation on over-voltage diode characteristics by exposing the diodes to californium-252 combined neutron/gamma radiation field. The irradiation of semiconductor over-voltage diodes causes severe degradation of their protection characteristics. On the other hand, gas-filled over-voltage diodes exhibit a temporal improvement of performance. The results are presented with the accompanying theoretical interpretations of the observed changes in over-voltage diode behaviour, based on the interaction of radiation with materials constituting the diodes.

  3. First results from the CARIBU facility: mass measurements on the r-process path.

    Science.gov (United States)

    Van Schelt, J; Lascar, D; Savard, G; Clark, J A; Bertone, P F; Caldwell, S; Chaudhuri, A; Levand, A F; Li, G; Morgan, G E; Orford, R; Segel, R E; Sharma, K S; Sternberg, M G

    2013-08-09

    The Canadian Penning Trap mass spectrometer has made mass measurements of 33 neutron-rich nuclides provided by the new Californium Rare Isotope Breeder Upgrade facility at Argonne National Laboratory. The studied region includes the 132Sn double shell closure and ranges in Z from In to Cs, with Sn isotopes measured out to A=135, and the typical measurement precision is at the 100 ppb level or better. The region encompasses a possible major waiting point of the astrophysical r process, and the impact of the masses on the r process is shown through a series of simulations. These first-ever simulations with direct mass information on this waiting point show significant increases in waiting time at Sn and Sb in comparison with commonly used mass models, demonstrating the inadequacy of existing models for accurate r-process calculations.

  4. Nuclear fission and the transuranium elements

    Energy Technology Data Exchange (ETDEWEB)

    Seaborg, G.T.

    1989-02-01

    Many of the transuranium elements are produced and isolated in large quantities through the use of neutrons furnished by nuclear fission reactions: plutonium (atomic number 94) in ton quantities; neptunium (93), americium (95), and curium (96) in kilogram quantities; berkelium (97) in 100 milligram quantities; californium (98) in gram quantities; and einsteinium (99) in milligram quantities. Transuranium isotopes have found many practical applications---as nuclear fuel for the large-scale generation of electricity, as compact, long-lived power sources for use in space exploration, as means for diagnosis and treatment in the medical area, and as tools in numerous industrial processes. Of particular interest is the unusual chemistry and impact of these heaviest elements on the periodic table. This account will feature these aspects. 9 refs., 5 figs.

  5. Production of highly pure einsteinium and fermium preparations

    Energy Technology Data Exchange (ETDEWEB)

    Andreev, O.I.; Tarasov, V.A.; Zotov, E.A.; Baranov, A.Yu. [Federal State Unitary Enterprise ' ' State Scientific Center of Russian Federation Research Institute of Atomic Reactors' ' (Russian Federation)

    2004-07-01

    Highly pure einsteinium and fermium preparations are in increased demand due to the progress of the following fields of modern sciences: Fundamental and applied nuclear physics. Heavy actinides are necessary for detailed study of structure and decay of a nucleus, as well as initial material both for nuclear synthesis of new superheavy elements and for manufacturing radioactive radiation sources. Fundamental and applied radiochemistry. Einsteinium and fermium preparations are required to investigate chemical properties of these hard-to-obtain elements and to improve technology of their recovery and purification. Nuclear medicine. Biologically active compounds labeled with alpha- emitting einsteinium and fermium may be applied in prospect for a radioimmunotherapy of oncological diseases. The principal method of einsteinium and fermium production is irradiation of curium or californium isotopes in a high-flux nuclear reactor. Large-scale production of transplutonium elements at RIAR enables also to produce regularly significant quantities of einsteinium and fermium. (orig.)

  6. Beta-delayed neutron spectroscopy using ion traps

    Science.gov (United States)

    Wang, Barbara; Czeszumska, A.; Siegl, K.; Caldwell, S.; Aprahamian, A.; Burkey, M.; Clark, J.; Levand, A.; Marley, S.; Morgan, G.; Norman, E.; Nystrom, A.; Orford, R.; Padgett, S.; Perez Galvan, A.; Savard, G.; Scielzo, N.; Sharma, K.; Strauss, S.

    2017-01-01

    Trapped radioactive ions suspended in vacuum allow for a new way to perform beta-delayed neutron spectroscopy. Decay branching ratios and energy spectra of the emitted neutrons are inferred from a measurement of the nuclear recoil, thereby circumventing the many limitations associated with direct neutron detection. Beta-delayed neutron measurements were carried out for 137-138,140I, 134-136Sb, and 144-145Cs at the Californium Rare Isotope Breeder Upgrade (CARIBU) facility at Argonne National Laboratory. The data collected are needed in many fields of basic and applied science such as nuclear energy, nuclear astrophysics, and stockpile stewardship. Results for the isotopes 135-136Sb and 140I will be presented. Supported by NSF under PHY-1419765, and U.S. DOE under NEUP 13-5485, DE-AC02-06CH11357 (ANL), DE-AC52-07NA27344 (LLNL), and DE-NA0000979 (NNSA).

  7. Environmental assessment of the thermal neutron activation explosive detection system for concourse use at US airports

    Energy Technology Data Exchange (ETDEWEB)

    Jones, C.G.

    1990-08-01

    This document is an environmental assessment of a system designed to detect the presence of explosives in checked airline baggage or cargo. The system is meant to be installed at the concourse or lobby ticketing areas of US commercial airports and uses a sealed radioactive source of californium-252 to irradiate baggage items. The major impact of the use of this system arises from direct exposure of the public to scattered or leakage radiation from the source and to induced radioactivity in baggage items. Under normal operation and the most likely accident scenarios, the environmental impacts that would be created by the proposed licensing action would not be significant. 44 refs., 19 figs., 18 tabs.

  8. TRIGA-TRAP: A penning trap mass spectrometer at the research reactor TRIGA Mainz

    Energy Technology Data Exchange (ETDEWEB)

    Smorra, Christian [Physikalisches Institut, Universitaet Heidelberg (Germany); Institut fuer Kernchemie, Universitaet Mainz (Germany); Blaum, Klaus [Physikalisches Institut, Universitaet Heidelberg (Germany); Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Block, Michael; Herfurth, Frank [GSI, Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany); Eberhardt, Klaus [Institut fuer Kernchemie, Universitaet Mainz (Germany); Eibach, Martin; Ketelaer, Jens; Ketter, Jochen; Knuth, Konstantin; Repp, Julia [Institut fuer Physik, Universitaet Mainz (Germany); Nagy, Szilard [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany)

    2009-07-01

    Nuclear masses represent the binding energies and, therefore, the sum of all interactions in the nucleus. They provide an important input parameter to nuclear structure models. Presently, a tremendous interest in masses of very exotic neutron-rich nuclides exists to support theoretical models for the nucleosynthesis via the rapid neutron capture process. The research reactor TRIGA Mainz provides access to a large variety of neutron-rich nuclides produced by thermal-neutron induced fission of an actinide target. The double-Penning trap mass spectrometer TRIGA-TRAP will perform high-precision mass measurements in this region of the nuclear chart as well as on actinides from uranium to californium. It also serves as a test facility for the development of new techniques that will be implemented in future facilities like MATS at FAIR (GSI, Darmstadt). The layout of TRIGA-TRAP as well as recent mass measurements are presented.

  9. Populations of selected microbial and fungal species growing on the surface of rape seeds following treatment with desiccants or plant growth regulators.

    Science.gov (United States)

    Frac, Magdalena; Jezierska-Tys, Stefania; Tys, Jerzy

    2010-01-01

    The aim of this study was to determine the effects of desiccants and plant growth regulators on selected microbial species affecting rape seeds, with special emphasis on the growth of fungi and identification of the genus and species composition. The experimental material in the study was seeds of winter rape cv. Californium that were collected from the field during combine harvest. The chemical agents applied, both desiccants and growth regulators, generally decreased the populations of bacteria occurring on the surface of rape seeds. The responses of fungi depended upon the type of agent applied and were manifested as either stimulation or inhibition of the growth of the fungal species. The fungi isolated from the surface of rape seeds were characteristic of those found in the field environment (Cladosporium and Penicillium) and typical for those present on the surface of rape seeds (Alternaria).

  10. Measurements of the neutron capture cross sections and incineration potentials of minor-actinides in high thermal neutron fluxes: Impact on the transmutation of nuclear wastes; Mesures des sections efficaces de capture et potentiels d'incineration des actinides mineurs dans les hauts flux de neutrons: Impact sur la transmutation des dechets

    Energy Technology Data Exchange (ETDEWEB)

    Bringer, O

    2007-10-15

    This thesis comes within the framework of minor-actinide nuclear transmutation studies. First of all, we have evaluated the impact of minor actinide nuclear data uncertainties within the cases of {sup 241}Am and {sup 237}Np incineration in three different reactor spectra: EFR (fast), GT-MHR (epithermal) and HI-HWR (thermal). The nuclear parameters which give the highest uncertainties were thus highlighted. As a result of fact, we have tried to reduce data uncertainties, in the thermal energy region, for one part of them through experimental campaigns in the moderated high intensity neutron fluxes of ILL reactor (Grenoble). These measurements were focused onto the incineration and transmutation of the americium-241, the curium-244 and the californium-249 isotopes. Finally, the values of 12 different cross sections and the {sup 241}Am isomeric branching ratio were precisely measured at thermal energy point. (author)

  11. Carbon Ion Therapy

    DEFF Research Database (Denmark)

    Bassler, Niels; Hansen, David Christoffer; Herrmann, Rochus;

    On the importance of choice of target size for selective boosting of hypoxic tumor subvolumina in carbon ion therapy Purpose: Functional imaging methods in radiotherapy are maturing and can to some extent uncover radio resistant structures found within a tumour entity. Selective boost of identified...... size and PTV position. Methods: Several treatment plans are produced with TRiP, using a 256x256x256 mm3 water phantom and SOBP optimization on physical dose. Box formed PTV volumes between 0.15 - 1010 cm3, and PTV positions ranging from 3 cm to 200 cm depth (relative...

  12. Upgrade and Extension of the Data Acquisition System for Propulsion and Gas Dynamic Laboratories

    Science.gov (United States)

    1992-06-01

    RW- 18 g DOCUmRNT FROG 59 256 13-Apr-92 8:45 RW-RW-RW- 18 9 VER CFO BOAT 6 256 24-Apr-92 16:51 RW-RW-RW- 18 9 HP6i44A MENU FROG 7 256 7-Apr-92 7:18 RW...port assigned, read the port 410 L-BINAND(PO,15) 1n. oer, and convert it to decimal 420 TSBIFT(PO,4) Iformat. 430 M- DIRAND (T,7) 440 Port read-10*8+L

  13. NODC Standard Product: Climatic Atlas of the Barents Sea 1998: Temperature, Salinity, Oxygen (NODC Accession 0000300)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NODC CD-ROM product (NODC-121) contains the time and space distribution of 74,256 ocean stations (temperature, salinity, and oxygen) occupied in the Barents Sea...

  14. Food for Thought: Cross-Classification and Category Organization in a Complex Real-World Domain.

    Science.gov (United States)

    Ross, Brian H.; Murphy, Gregory L.

    1999-01-01

    Seven studies involving 256 undergraduates examined how people represent, access, and make inferences about the real-world category domain, foods. Results give a detailed picture of the use of cross-classification in a complex domain. (SLD)

  15. A Medipix2-based imaging system for digital mammography with silicon pixel detectors

    CERN Document Server

    Bisogni, M G; Fantacci, M E; Mettivier, G; Montesi, M C; Novelli, M; Quattrocchi, M; Rosso, V; Russo, P; Stefanini, A

    2004-01-01

    In this paper we present the first tests of a digital imaging system based on a silicon pixel detector bump-bonded to an integrated circuit operating in single photon counting mode. The X-rays sensor is a 300 mu m thick silicon, 14 by 14 mm/sup 2/, upon which a matrix of 256 * 256 pixels has been built. The read-out chip, named MEDIPIX2, has been developed at CERN within the MEDIPIX2 Collaboration and it is composed by a matrix of 256 * 256 cells, 55 * 55 mu m/sup 2/. The spatial resolution properties of the system have been assessed by measuring the square wave resolution function (SWRF) and first images of a standard mammographic phantom were acquired using a radiographic tube in the clinical irradiation condition. (5 refs).

  16. A New Method for Impossible Differential Cryptanalysis of 8-Round Advanced Encryption Standard

    Institute of Scientific and Technical Information of China (English)

    CHEN Jie; HU Yupu; WEI Yongzhuang

    2006-01-01

    This paper first presents an impossible differential property for 5-round Advanced Encryption Standard (AES) with high probability. Based on the property and the impossible differential cryptanalytic method for the 5-round AES, a new method is proposed for cryptanalyzing the 8-round AES-192 and AES-256. This attack on the reduced 8-round AES-192 demands 2121 words of memory, and performs 2148 8-round AES-192 encryptions. This attack on the reduced 8-round AES-256 demands 2153 words of memory, and performs 2180 8-round AES-256 encryptions. Furthermore, both AES-192 and AES-256 require about 298 chosen plaintexts for this attack, and have the same probability that is only 2-3 to fail to recover the secret key.

  17. AcEST: BP917664 [AcEST

    Lifescience Database Archive (English)

    Full Text Available uery: 256 TDFAFANHVIGHVREEEAVWLPKNLSFKYIREKDIALPKNPS*GRKMSYGAIPSTSHSST 77 T AFA+ +G E++A WLPK L + I + P+ G ++S G + Sbjct: 176 TGLAFAS...IALGGSAEQKAEWLPKMLDLETIGAFGLTEPEG---GSQVSQGMRTTCQRDGD 23

  18. Drug: D06601 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D06601 Drug Hemoglobin glutamer-256 (human) (USAN); Polyheme (TN) Immediate replacement of lost oxygen-carry...ing capacity due to red blood cell loss CAS: 679404-95-6 PubChem: 47208252 ...

  19. Adlayer of hydroquinone on Pt(111) in solution and in a vacuum studied by STM and LEED.

    Science.gov (United States)

    Inukai, Junji; Wakisaka, Mitsuru; Yamagishi, Masaoki; Itaya, Kingo

    2004-08-31

    Hydroquinone (HQ) adlayers were formed on Pt(111) in HF solution and in a vacuum. By using scanning tunneling microscopy (STM) in solution, it was revealed that HQ formed an ordered structure on Pt(111) with a strong attractive interaction between two adjacent hydroxyl groups in neighboring HQ molecules. After the sample was transferred into a vacuum, low-energy electron diffraction (LEED) measurement was performed, which showed that the (2.56 x 2.56)R16 degrees incommensurate structure of the HQ adlayer was formed in solution. The HQ adlayer on Pt(111) was formed also by vapor deposition, and the identical (2.56 x 2.56)R16 degrees adlayer structure was found by LEED and STM in a vacuum.

  20. 76 FR 10587 - Product Cancellation Order for Certain Pesticide Registrations

    Science.gov (United States)

    2011-02-25

    ... Deltamethrin Tralomethrin 000264-01010 Scout X-tra Gel Tralomethrin Insecticide. 000432-00755 Saga WP... Isopropyl alcohol Glass & Surface Propylene glycol Cleaner. 005741-00009 Sparquat 256 1-Decanaminium,...

  1. Review: Leonard and Virginia Woolf, the Hogarth Press and the Networks of Modernism, Ed. Helen Southworth (Edinburgh: Edinburgh UP, 2010

    Directory of Open Access Journals (Sweden)

    Caitlyn Tierney Caldwell

    2014-12-01

    Full Text Available A review of Helen Southworth (Editor, Leonard and Virginia Woolf, the Hogarth Press and the Networks of Modernism. ix + 256 pp., notes, appendix, index. Edinburgh: Edinburgh University Press, 2010. £75

  2. Sequence Classification: 894411 [

    Lifescience Database Archive (English)

    Full Text Available and position 35 in pre-tRNA(Tyr); Asp(256) mutation abolishes activity; conserved in archaea, some bacteria, and vertebrates; Pus7p || http://www.ncbi.nlm.nih.gov/protein/6324817 ...

  3. 77 FR 71588 - Alaska Electric Light and Power Company, et al.; Notice of Petition for Declaratory Order

    Science.gov (United States)

    2012-12-03

    ... County, Project No. 2114-256 Washington. Sabine River Authority of Texas and Sabine Project No. 2305-040... No. 2 of Grant County, Washington, Project No. 2114; Sabine River Authority of Texas and Sabine...

  4. Attosecond nanotechnology: NEMS of energy storage and nanostructural transformations in materials

    Science.gov (United States)

    Beznosyuk, Sergey A.; Zhukovsky, Mark S.; Maslova, Olga A.

    2015-10-01

    The attosecond technology of the nanoelectromechanical system (NEMS) energy storage as active center fast transformation of nanostructures in materials is considered. The self-organizing relaxation of the NEMS active center containing nanocube of 256-atoms limited by planes (100) in the FCC lattice matrix of 4d-transition metals (Ru, Rh, Pd) is described by the quantum NEMS-kinetics (NK) method. Typical for these metals change of the NEMS active center physicochemical characteristics during the time of relaxation is presented. There are three types of intermediate quasistationary states of the NEMS active center. Their forms are plainly distinguishable. The full relaxed NEMS active centers (Ru256, Rh256, Pd256) accumulate next storage energies: ERu = 2.27 eV/at, ERh = 1.67 eV/at, EPd = 3.02 eV/at.

  5. Review: Abdul Raufu Mustapha (ed., Sects & Social Disorder: Muslim Identities & Conflict in Northern Nigeria (2014

    Directory of Open Access Journals (Sweden)

    Heinrich Bergstresser

    2015-01-01

    Full Text Available Review of the edited volume:Abdul Raufu Mustapha (ed., Sects & Social Disorder: Muslim Identities & Conflict in Northern Nigeria, Martlesham: James Currey, 2014, ISBN 9781847011077, 256 pages

  6. Sõlmes alumiiniummaja = Aluminium House in a Knot

    Index Scriptorium Estoniae

    2008-01-01

    Alumiiniumplaatidega kaetud sõlmekujulise plaaniga eramu (256 m2). Arhitektid: Peeter Pere, Urmas Muru. Projektbüroo: Muru & Pere. Konsultant Katrin Kaevats. Valmis: 2007. 2 plaani, 4 värv. välisvaadet, sisevaade

  7. A quantitative comparison of the TERA modeling and DFT magnetic resonance image reconstruction techniques.

    Science.gov (United States)

    Smith, M R; Nichols, S T; Constable, R T; Henkelman, R M

    1991-05-01

    The resolution of magnetic resonance images reconstructed using the discrete Fourier transform (DFT) algorithm is limited by the effective window generated by the finite data length. The transient error reconstruction approach (TERA) is an alternative reconstruction method based on autoregressive moving average (ARMA) modeling techniques. Quantitative measurements comparing the truncation artifacts present during DFT and TERA image reconstruction show that the modeling method substantially reduces these artifacts on "full" (256 X 256), "truncated" (256 X 192), and "severely truncated" (256 X 128) data sets without introducing the global amplitude distortion found in other modeling techniques. Two global measures for determining the success of modeling are suggested. Problem areas for one-dimensional modeling are examined and reasons for considering two-dimensional modeling discussed. Analysis of both medical and phantom data reconstructions are presented.

  8. The Knowledge Based Information Economy

    OpenAIRE

    1990-01-01

    Working Paper No. 256 is published as "The Knowledge Based Information Economy" (authors: Gunnar Eliasson, Stefan Fölster, Thomas Lindberg, Tomas Pousette and Erol Taymaz). Stockholm: Industrial Institute for Economic and Social Research and Telecon, 1990.

  9. AGARD Flight Test Techniques Series. Volume 3. Identification of Dynamic Systems - Applications to Aircraft. Part 1. The Output Error Approach

    Science.gov (United States)

    1986-12-01

    Generalized Matrix Eigenvalue Problems. SIAM J. Numer. Anal., vol. 10, no. 2, pp. 241-256, Apr. 1973. Moler, Cleve; and Van Loan, Charles: Nineteen Dubious Ways to Compute the Exponential of a Matrix . SIAM

  10. Fujiwara, Aya, Ethnic Elites and Canadian Identity: Japanese, Ukrainians and Scots, 1919-1971.

    Directory of Open Access Journals (Sweden)

    Heather Metcalfe

    2013-10-01

    Full Text Available Fujiwara, Aya, Ethnic Elites and Canadian Identity: Japanese, Ukrainians and Scots, 1919-1971. Winnipeg: University of Manitoba Press, 2012. Pp. xi + 256. ISBN 978-0-8875-737-8 (paperback. $27.95.

  11. 78 FR 43180 - Procurement List; Proposed Additions and Deletions

    Science.gov (United States)

    2013-07-19

    ... Bottle, GS High Dilution 256 Neutral Disinfectant, Silk Screened, 12-32oz bottles NPA: Susquehanna... and Printing, 9000 Blue Mound Road, Fort Worth, TX NPA: Goodwill Industrial Services of Fort...

  12. Reference: 16 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available ion. 2 256-68 12533513 2003 Jan Genes & development Allenbach Laure|Chory Joanne|Davis Seth J|Fankhauser Christian|Fiechter Vincent|Millar Andrew J|Salathia Neeraj|Staiger Dorothee

  13. Enhancing Recruitment and Retention of Volunteers in the U.S. Coast Guard Auxiliary

    Science.gov (United States)

    2008-12-01

    Leedy and Ormrod .256 Charts of the both datasets were also generated. 252 U.S. Coast Guard, Report to...www.nationalservice.gov/ (accessed November 11, 2008). 256 Paul D. Leedy and Jeanne Ellis Ormrod , Practical Research: Planning and Design, 8th Edition (Upper...were entered into a Microsoft® Excel spreadsheet, analyzed, compared, and interpreted using quantitative statistics outlined in Leedy and Ormrod .261

  14. AcEST: DK950215 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 8 sp|P59671|RL3_NEUCR 60S ribosomal protein L3 OS=Neurospora crass... 256 5e-68 sp|P49149|RL3_TOXCA 60S ribosomal protein L3 OS=Toxoc...ara canis G... 256 9e-68 sp|Q92901|RL3L_HUMAN 60S ribosomal protein L3-like OS=Homo

  15. GETDB: 104775 [GETDB

    Lifescience Database Archive (English)

    Full Text Available inal cells, mouth fook (26-R-6), sg dorsal crescent of proximal leg, ubiquitous lethal - comment1:A, comme...ethal Also known as - Original Comments comment1:A, comment2:56A Disc (Image) d1 d2 d3 Disc (number) 3 Embry...nt2:56A d1 d2 d3 - - - Show 104775 DGRC Number 104775 Link to Original Genotype w[*

  16. Structure-guided modification of Rhizomucor miehei lipase for production of structured lipids.

    Directory of Open Access Journals (Sweden)

    Jun-Hui Zhang

    Full Text Available To improve the performance of yeast surface-displayed Rhizomucor miehei lipase (RML in the production of human milk fat substitute (HMFS, we mutated amino acids in the lipase substrate-binding pocket based on protein hydrophobicity, to improve esterification activity. Five mutants: Asn87Ile, Asn87Ile/Asp91Val, His108Leu/Lys109Ile, Asp256Ile/His257Leu, and His108Leu/Lys109Ile/Asp256Ile/His257Leu were obtained and their hydrolytic and esterification activities were assayed. Using Discovery Studio 3.1 to build models and calculate the binding energy between lipase and substrates, compared to wild-type, the mutant Asp256Ile/His257Leu was found to have significantly lower energy when oleic acid (3.97 KJ/mol decrease and tripalmitin (7.55 KJ/mol decrease were substrates. This result was in accordance with the esterification activity of Asp256Ile/His257Leu (2.37-fold of wild-type. The four mutants were also evaluated for the production of HMFS in organic solvent and in a solvent-free system. Asp256Ile/His257Leu had an oleic acid incorporation of 28.27% for catalyzing tripalmitin and oleic acid, and 53.18% for the reaction of palm oil with oleic acid. The efficiency of Asp256Ile/His257Leu was 1.82-fold and 1.65-fold that of the wild-type enzyme for the two reactions. The oleic acid incorporation of Asp256Ile/His257Leu was similar to commercial Lipozyme RM IM for palm oil acidolysis with oleic acid. Yeast surface-displayed RML mutant Asp256Ile/His257Leu is a potential, economically feasible catalyst for the production of structured lipids.

  17. Structure-guided modification of Rhizomucor miehei lipase for production of structured lipids.

    Science.gov (United States)

    Zhang, Jun-Hui; Jiang, Yu-Yan; Lin, Ying; Sun, Yu-Fei; Zheng, Sui-Ping; Han, Shuang-Yan

    2013-01-01

    To improve the performance of yeast surface-displayed Rhizomucor miehei lipase (RML) in the production of human milk fat substitute (HMFS), we mutated amino acids in the lipase substrate-binding pocket based on protein hydrophobicity, to improve esterification activity. Five mutants: Asn87Ile, Asn87Ile/Asp91Val, His108Leu/Lys109Ile, Asp256Ile/His257Leu, and His108Leu/Lys109Ile/Asp256Ile/His257Leu were obtained and their hydrolytic and esterification activities were assayed. Using Discovery Studio 3.1 to build models and calculate the binding energy between lipase and substrates, compared to wild-type, the mutant Asp256Ile/His257Leu was found to have significantly lower energy when oleic acid (3.97 KJ/mol decrease) and tripalmitin (7.55 KJ/mol decrease) were substrates. This result was in accordance with the esterification activity of Asp256Ile/His257Leu (2.37-fold of wild-type). The four mutants were also evaluated for the production of HMFS in organic solvent and in a solvent-free system. Asp256Ile/His257Leu had an oleic acid incorporation of 28.27% for catalyzing tripalmitin and oleic acid, and 53.18% for the reaction of palm oil with oleic acid. The efficiency of Asp256Ile/His257Leu was 1.82-fold and 1.65-fold that of the wild-type enzyme for the two reactions. The oleic acid incorporation of Asp256Ile/His257Leu was similar to commercial Lipozyme RM IM for palm oil acidolysis with oleic acid. Yeast surface-displayed RML mutant Asp256Ile/His257Leu is a potential, economically feasible catalyst for the production of structured lipids.

  18. No decrease in susceptibility to NVC-422 in multiple-passage studies with methicillin-resistant Staphylococcus aureus, S. aureus, Pseudomonas aeruginosa, and Escherichia coli.

    Science.gov (United States)

    D'Lima, Louisa; Friedman, Lisa; Wang, Lu; Xu, Ping; Anderson, Mark; Debabov, Dmitri

    2012-05-01

    Twenty-five serial passages of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus and 50 passages of methicillin-resistant Staphylococcus aureus resulted in no significant increase in NVC-422 MICs, while ciprofloxacin MICs increased 256-fold for E. coli and 32-fold for P. aeruginosa and S. aureus. Mupirocin, fusidic acid, and retapamulin MICs for MRSA increased 64-, 256-, and 16-fold, respectively. No cross-resistance to NVC-422 was observed with mupirocin-, fusidic acid-, and retapamulin-resistant strains.

  19. Small Satellites and RPAs in Global-Change Research

    Science.gov (United States)

    1992-12-01

    The Urban Climate (Academic Press, New York). 7. Mitigation Panel Report of NAS Committee on Policy Implications of Greenhouse Warming (in press, 1991...used to unfold the net radiation budget from the raw data, using statistical models of the bi-directional radiance function and taking into account the...hybrid) mode and Configuration 256 x 256 Photovoltaic 165 ONR proposes to use conventional silicon CCD arrays as detectors, but they have rather low

  20. Deoxyribozymes inhibit the expression of periodl gene in vitro

    Institute of Scientific and Technical Information of China (English)

    ZHOU Wei; WANG Yueqi; LIU Yanyou; PENG Wenzhen; XIAO Jing; ZHU Bin; WANG Zhengrong

    2005-01-01

    To investigate the effect of two deoxyribozymes targeting periodl (perl) mRNA in vitro for exploring a novel gene therapy approach about circadian rhythm diseases, the specific deoxyribozymes targeting perl were designed and synthesized chemically following MFold analysis according to its mRNA secondary structure, perl RNA fragments were prepared by in vitro transcription of pcDNA3.1 (+)-perl164:256. The cleavage reactions containing deoxyribozymes and perl RNA fragments were performed under certain conditions. With the transfection technique mediated by LipofectAMINETM, pcDNA3-perl and DRz164 or DRz256 were introduced into NIH3T3 cells. The effects of deoxyribozymes on perl were studied by reverse transcript-polymerase chain reaction (RT-PCR) and flow cytometry (FCM). When deoxyribozymes and RNA transcripts were incubated under the adopted conditions at 37℃ for 2 h, about 63% of perl164:256 RNA transcripts were cleaved by DRz164 and about 50.5% by DRz256. After cotransfecting pcDNA3-perl with DRz164 or DRz256, the expression of perl mRNA was decreased, as indicated by RT-PCR semi-quantity analysis. FCM analysis showed that Perl protein was inhibited. Both DRz164 and DRz256 targeting perl have the specific cleavage activity toward perl mRNA in vitro and can highly block the expression of perl gene in cellular milieu.

  1. Impossible differential cryptanalysis of advanced encryption standard

    Institute of Scientific and Technical Information of China (English)

    CHEN Jie; HU YuPu; ZHANG YueYu

    2007-01-01

    Impossible differential cryptanalysis is a method recovering secret key, which gets rid of the keys that satisfy impossible differential relations. This paper concentrates on the impossible differential cryptanalysis of Advanced Encryption Standard (AES)and presents two methods for impossible differential cryptanalysis of 7-round AES-192 and 8-round AES-256 combined with time-memory trade-off by exploiting weaknesses in their key schedule. This attack on the reduced to 7-round AES-192 requires about 294.5 chosen plaintexts, demands 2129 words of memory, and performs 2157 7-round AES-192 encryptions. Furthermore, this attack on the reduced to 8-round AES-256 requires about 2101 chosen plaintexts, demands 2201 words of memory, and performs 2228 8-round AES-256 encryptions.

  2. Image Binarization Using Multi-Layer Perceptron: A Semi-Supervised Approach

    Directory of Open Access Journals (Sweden)

    Amlan Raychaudhuri

    2012-04-01

    Full Text Available In this paper, we have discussed the Image Binarization technique using Multilayer Perceptron (MLP. The purpose of Image Binarization is to extract the lightness (brightness, density as a feature amount from the Image. It converts a gray-scale image of up to 256 gray levels to a black and white image. We use Backpropagation algorithm for training MLP. It is a supervised learning technique. Here Kmeans clustering algorithm has been used for clustering a 256 × 256 gray-level image. The dataset obtained by this is fed to the MLP and processed in a Semi-Supervised way where some training samples are taken as Known patterns (for training and others as Unknown patterns. Finally through this approach a Binarized image is produced.

  3. Precessing jets and molecular outflows a 3-D numerical study

    CERN Document Server

    Cliffe, J A; Frank, Adam

    1996-01-01

    We present 3-D numerical hydrodynamical simulations of precessing supersonic heavy jets to explore how well they serve as a model for generating molecular outflows from Young Stellar Objects. The dynamics are studied with a number of high resolution simulations on a Cartesian grid (128x128x128 zones) using a high order finite difference method. A range of cone angles and precession rates were included in the study. Two higher resolution runs (256x256x256 zones) were made for comparison in order to confirm numerical convergence of global flow characteristics. Morphological, kinematical and dynamical characteristics of precessing jets are described and compared to important properties of straight jets and also to observations of YSOs. In order to examine the robustness of precessing jets as a mean to produce molecular outflows around Young Stellar Objects, ``synthetic observations'' of the momentum distributions of the simulated precessing jets are compared to observations of molecular outflows. It is found tha...

  4. Role of multiple phosphorylation sites in the COOH-terminal tail of aquaporin-2 for water transport: evidence against channel gating

    DEFF Research Database (Denmark)

    Moeller, Hanne B; Macaulay, Nanna; Knepper, Mark A;

    2009-01-01

    in the COOH-terminal tail of AQP2 on protein function. When expressed in Xenopus laevis oocytes, prevention of AQP2 phosphorylation at S256A (S256A-AQP2) reduced osmotic water permeability threefold compared with wild-type (WT) AQP2-injected oocytes. In contrast, prevention of AQP2 single phosphorylation at S...... demonstrated that lack of phosphorylation at S256, S261, S264, or S269 had no effect on AQP2 unit water transport. Similarly, no effect on AQP2 unit water transport was observed for the 264D and 269D forms, indicating that phosphorylation of the COOH-terminal tail of AQP2 is not involved in gating...

  5. Klebsiella pneumoniae with multiple antimicrobial resistance

    Directory of Open Access Journals (Sweden)

    Caio Mendes

    2004-02-01

    Full Text Available A Klebsiella pneumoniae strain was isolated from the urine of a patient at one of the centers participating in the 2001 edition of the MYSTIC program in Brazil. The initial phenotypic findings of the isolated K. pneumoniae presented an unusual MIC of 8 mug/mL to meropenem, 2 mug/mL to imipenem, elevated MICs to broad spectrum cephalosporins (ceftazidime/cefotaxime/cefepime MIC > 256 mug/mL, aminoglycosides (gentamycin > 256 mug/mL and tobramycin = 48 mug/mL, piperacillin/tazobactam (MIC > 256 mug/mL and susceptibility to ciprofloxacin (MIC = 0.25 mug/mL. The strain also tested positive for ESBL production with double-disk and E-test methodologies. More detailed investigation revealed that the strain produced a SHV-4 type enzyme and also lacked a 36 kDa outer membrane porin.

  6. Improved Impossible Differential Attacks on Large-Block Rijndael

    DEFF Research Database (Denmark)

    Wang, Qingju; Gu, Dawu; Rijmen, Vincent;

    2012-01-01

    . The improvement can lead to 10-round attack on Rijndael-256 as well. With 2198.1 chosen plaintexts, an attack is demonstrated on 9-round Rijndael-224 with 2 195.2 encryptions and 2140.4 bytes memory. Increasing the data complexity to 2216 plaintexts, the time complexity can be reduced to 2130 encryptions...... and the memory requirements to 2 93.6 bytes. For 9-round Rijndael-256, we provide an attack requiring 2229.3 chosen plaintexts, 2194 encryptions, and 2 139.6 bytes memory. Alternatively, with 2245.3 plaintexts, an attack with a reduced time of 2127.1 encryptions and a memory complexity of 290.9 bytes can...... be mounted. With 2244.2 chosen plaintexts, we can attack 10-round Rijndael-256 with 2253.9 encryptions and 2186.8 bytes of memory....

  7. 讯景6600 DDR2荣誉版

    Institute of Scientific and Technical Information of China (English)

    西疯古盗

    2005-01-01

    XFX(讯景)近日推出了一款6600 DDR2 256MB荣誉版,与先前的6600系列显卡不同,该产品配备256MB DDR2显存,核心/显存频率为较高的400/800MHz,且采用NVIDIA最新的P295公版PCB。6600 DDR2版沿用了XFX传统的深蓝色PCB,采用8频英飞凌2.5ns GDDR2显存,组成256MB/128bit规格。

  8. Research from an Operatonal Space Weather Satellite

    Science.gov (United States)

    de Koning, C. A.

    2015-12-01

    STEREO real-time white-light images, or beacon images, are heavily compressed, 256x256 pixel images. And yet, they show the same transient features that are in the STEREO science images, which are up to 2048x2048 pixels. Based on our experience with STEREO beacon images, we demonstrate that operational images can be used to do good quality science. We also discuss the limitations of operational data for scientific research. Finally, we discuss ways in which a predominantly operational mission could be combined with science mission, to further enhance research.

  9. AcEST: BP913260 [AcEST

    Lifescience Database Archive (English)

    Full Text Available YMU001_000028_C08 256 Adiantum capillus-veneris mRNA. clone: YMU001_000028_C08. BP913260 - Show BP913260...is mRNA. clone: YMU001_000028_C08. Accession BP913260 Tissue type prothallium Developmental stage - Contig I...arch programs, Nucleic Acids Res. 25:3389-3402. Query= BP913260|Adiantum capillus-veneris mRNA, clone: YMU00...25:3389-3402. Query= BP913260|Adiantum capillus-veneris mRNA, clone: YMU001_000028_C08. (256 letters) Databa

  10. First Overtone Frequency Stimulated Quartz Tuning Fork Used for Shear-Force Scanning Near-Field Optical Microscopy

    Institute of Scientific and Technical Information of China (English)

    刘晟; 孙家林; 孙红三; 谭晓靖; 时硕; 郭继华; 赵钧

    2003-01-01

    The conventional 32.768 kHz tuning fork is stimulated at its first overtone resonant frequency of ~190 kHz for shear-force distance control.The time constant is measured to be 0.54 ms and it decreases about 40 times faster than that of the fundamental frequency(20.76ms).The cross section of a corn root with a height difference of ~ 3μm is imaged at a scan speed of 12μm/s for 256 × 256 pixels.

  11. Development of multichannel low-energy neutron spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Arikawa, Y., E-mail: arikawa-y@ile.osaka-u.ac.jp; Nagai, T.; Abe, Y.; Kojima, S.; Sakata, S.; Inoue, H.; Utsugi, M.; Iwasa, Y.; Sarukura, N.; Nakai, M.; Shiraga, H.; Fujioka, S.; Azechi, H. [Institute of Laser Engineering, Osaka University, 2-6 Yamada-oka, Suita, Osaka (Japan); Murata, T. [Kumamoto University, 2-40-1 Kurokami, Kumamoto 860-8555 (Japan)

    2014-11-15

    A multichannel low-energy neutron spectrometer for down-scattered neutron (DSN) measurements in inertial confinement fusion (ICF) experiments has been developed. Our compact-size 256-channel lithium-glass-scintillator-based spectrometer has been implemented and tested in ICF experiments with the GEKKO XII laser. We have performed time calibration of the 256-channel analog-to-digital convertor system used for DSN measurements via X-ray pulse signals. We have clearly observed the DD-primary fusion neutron signal and have successfully studied the detector's impulse response. Our detector is soon to be implemented in future ICF experiments.

  12. An Experimental Study of an Ultra-Mobile Vehicle for Off-Road Transportation.

    Science.gov (United States)

    1983-07-01

    considered hostile to a human being. Examples are remote planet exploration, fire fighting, material nandling in nuclear power plants, and mining [1...vision system employes a linear array camera ( Reticon RL25bC 256 x 1) which images a narrow strip accross the belt perpendicular to the belt’s direction of...and Reticon LC600C 256 x 1 17 Light Linear Array Source Camera %% \\ % ’ !Conveyor 40M Belt Figure ’.4 Arrangement of the CONSIGHT System. (a) (b

  13. [Anti-toxoplasma antibodies in bovine serums in Jaboticabal County; São Paulo, Brazil].

    Science.gov (United States)

    Costa, A J; Avila, F A; Kassai, N; Paulillo, A C; Barbosa da Silva, M; Galesco, H

    1978-01-01

    Sera of 204 cows in Jaboticabal, S.P., Brazil were examined by indirect immunofluorescent test for detecting anti-Toxoplasma antibody. Assuming titers from 1:64 as indicative of toxoplasmic infection it was observed 32.3% of positive reactions. The antibody titers even to 1:256 represented 7.8% of the reacting animals. The serological titers varied from 1:64 to 1:256. No clinical story could be correlated with the reacting animals and no isolation was performed.

  14. Compressive wavefront sensing with weak values.

    Science.gov (United States)

    Howland, Gregory A; Lum, Daniel J; Howell, John C

    2014-08-11

    We demonstrate a wavefront sensor that unites weak measurement and the compressive-sensing, single-pixel camera. Using a high-resolution spatial light modulator (SLM) as a variable waveplate, we weakly couple an optical field's transverse-position and polarization degrees of freedom. By placing random, binary patterns on the SLM, polarization serves as a meter for directly measuring random projections of the wavefront's real and imaginary components. Compressive-sensing optimization techniques can then recover the wavefront. We acquire high quality, 256 × 256 pixel images of the wavefront from only 10,000 projections. Photon-counting detectors give sub-picowatt sensitivity.

  15. Study of hard X-ray dose enhancement effects for some kinds of semiconductor devices

    CERN Document Server

    Guo Hong Xia; Chen Yu Sheng; Zhou Hui; He Chao Hui; Xie Ya Ning; Huang Yu Ying; He Wei; Hu Tian Dou

    2002-01-01

    Experimental results of X-ray dose enhancement effects are given for CMOS4069 and floating gate ROMs irradiated in Beijing Synchrotron Radiation Facility and in cobalt source. Shift of threshold voltage vs. total dose for CMOS4069 and the errors vs. total dose for 28f256 and 29c256 have been tested on line and the equivalent relation of total dose damage under the same accumulated dose is provided comparing the response of devices irradiated by X-ray and gamma-ray source. These results can be provided for X-ray radiation hardening technology as an effective evaluation data

  16. AcEST: DK950225 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ... 256 5e-67 tr|A1Y9I8|A1Y9I8_TOBAC Chloroplast post-illumination chlorophyll... 254 3e-66 tr|A9PFG9|A9PFG9...a m... 245 2e-63 tr|A1Y9I7|A1Y9I7_MAIZE Chloroplast post-illumination chlorophyll...YANVD 255 Query: 549 DGSCPYISDESSD 587 DGSCP +S + Sbjct: 256 DGSCPLELSDSDE 268 >tr|A1Y9I8|A1Y9I8_TOBAC Chloroplast post-illuminati

  17. Pulsatile microvascular blood flow imaging by short-time Fourier transform analysis of ultrafast laser holographic interferometry

    CERN Document Server

    Puyo, L; Rancillac, A; Simonutti, M; Paques, M; Sahel, J A; Fink, M; Atlan, M

    2015-01-01

    We report on wide-field imaging of pulsatile microvascular blood flow in the exposed cerebral cortex of a mouse by holographic interferometry. We recorded interferograms of laser light backscattered by the tissue, beating against an off-axis reference beam with a 50 kHz framerate camera. Videos of local Doppler contrasts were rendered numerically by Fresnel transformation and short-time Fourier transform analysis. This approach enabled instantaneous imaging of pulsatile blood flow contrasts in superficial blood vessels over 256 x 256 pixels with a spatial resolution of 10 microns and a temporal resolution of 20 ms.

  18. Intégration d'un Nouveau Marqueur dans le Codeur d'Images EZW basé sur les Ondelettes

    OpenAIRE

    Chouchane, Sabrina; Puech, William

    2005-01-01

    National audience; Dans cet article, nous présentons une nouvelle méthode de tatouage non aveugle à clef secrète effectuant un multimarquage dans la même image lors de son codage avec la méthode EZW basée sur la transformée en ondelettes. La détection des marques est cependant faite lors de la décompression. L'algorithme, testé sur des images de taille 256 x 256 en niveaux de gris, reste robuste aux attaques tant que l'image reste exploitable.

  19. The Temperature Dependence of the Debye-Waller Factor of Magnesium

    DEFF Research Database (Denmark)

    Sledziewska-Blocka, D.; Lebech, Bente

    1976-01-01

    The temperature dependence of the average Debye-Waller factor for magnesium was measured by means of neutron diffraction spectrometry. The experimental results obtained in the temperature range from 5 to 256 K are compared with theoretical calculations, using the harmonic and quasi-harmonic appro......The temperature dependence of the average Debye-Waller factor for magnesium was measured by means of neutron diffraction spectrometry. The experimental results obtained in the temperature range from 5 to 256 K are compared with theoretical calculations, using the harmonic and quasi...

  20. WiMAX radio-on-fibre in 118-km long-reach PON with deployed fibre

    DEFF Research Database (Denmark)

    Prince, Kamau; Osadchiy, Alexey Vladimirovich; Tafur Monroy, Idelfonso

    2009-01-01

    We demonstrate a radio over fibre link supporting 256-QAM / 12 Mbaud WiMAX signalling over 118-km long-reach PON with deployed fibre. Our colourless implementation uses commercially-available, low-complexity devices typically used in TDM-PON or WDM-PON.......We demonstrate a radio over fibre link supporting 256-QAM / 12 Mbaud WiMAX signalling over 118-km long-reach PON with deployed fibre. Our colourless implementation uses commercially-available, low-complexity devices typically used in TDM-PON or WDM-PON....

  1. USAF Summer Research Program - 1993 High School Apprenticeship Program Final Reports, Volume 15, Wright Laboratory

    Science.gov (United States)

    1993-12-01

    change this name into one that will describe the function of the application because this will be the name referee to in the written code. * 3...Decreasing Row to Column Ratio ( DRC ) Algorithm data. To do this, we reversed the original FOM data and evaluated it sinmlay to the IRC data. Using the...5 256 then evaluated the data as seen if the partitons were looked at in reverse order as the DRC data: PARTrTION NUMBER POM 1 256 2 28 3 28 4 28 5

  2. United States Air Force Summer Research Program -- 1993 Summer Research Program Final Reports. Volume 15. Wright Laboratory

    Science.gov (United States)

    1993-01-01

    will be "Framel." The user must change this name into one that will describe the function of the application because this will be the name referee to in...2 28 3 124 4 48 5 256 lbm Vwuougd tbs dam a u md f bspaiddm au s lookind at inseee toy nb wr. tu l DRC duaw PAR.TMrONNUNMB 1CM 1 256 2 28 3 28 4 28 5...x8 glinin mr then Menmy DRC dua. We again developed a dwrt hCdasoft QBASIC prop= to do dos nmoazy d~aadvailadon We then plotted Wei damn with Mcmuod

  3. HF-hash : Hash Functions Using Restricted HFE Challenge-1

    CERN Document Server

    Dey, Dhananjoy; Gupta, Indranath Sen

    2009-01-01

    Vulnerability of dedicated hash functions to various attacks has made the task of designing hash function much more challenging. This provides us a strong motivation to design a new cryptographic hash function viz. HF-hash. This is a hash function, whose compression function is designed by using first 32 polynomials of HFE Challenge-1 with 64 variables by forcing remaining 16 variables as zero. HF-hash gives 256 bits message digest and is as efficient as SHA-256. It is secure against the differential attack proposed by Chabaud and Joux as well as by Wang et. al. applied to SHA-0 and SHA-1.

  4. Mean-field and Monte Carlo calculations of the three-dimensional structure factor for YBa2Cu3O6+x

    DEFF Research Database (Denmark)

    Fiig, Thomas; Andersen, Niels Hessel; Lindgård, Per-Anker

    1996-01-01

    We develop a general mean-field matrix theory for calculating phase boundaries and structure factors for a class of lattice gas Hamiltonians, We investigate the oxygen ordering in YBa2Cu3O6+x by applying the theory and by Monte Carlo simulation using an extension to three dimensions of the two......-dimensional anisotropic next nearest neighbor lattice gas model. The calculation of the structure factor in three spatial dimensions on a 256 x 256 x 16 system has been implemented on a massively parallel computer, the Connection Machine CM2. This allows for an extremely accurate determination of the line shape...

  5. AcEST: DK959931 [AcEST

    Lifescience Database Archive (English)

    Full Text Available etetrahydrofolate reductase 1 OS=Arabidopsis thaliana GN=MTHFR1 PE=1 SV=1 Length = 592 Score = 256 bits (655...ofolate reductase 2 OS=Arabidopsis thaliana GN=MTHFR2 PE=1 SV=2 Length = 594 Score = 256 bits (653), Expect ..._HUMAN Methylenetetrahydrofolate reductase OS=Homo sapiens GN=MTHFR PE=1 SV=3 Length = 656 Score = 123 bits ...NYAVDLVKHIRSEFGDYFDICVAGYP 198 >sp|Q60HE5|MTHR_MACFA Methylenetetrahydrofolate reductase OS=Macaca fascicularis GN=MTHFR

  6. Photonic network-on-chip architecture using 3D integration

    Science.gov (United States)

    Biberman, Aleksandr; Sherwood-Droz, Nicolás; Zhu, Xiaoliang; Preston, Kyle; Hendry, Gilbert; Levy, Jacob S.; Chan, Johnnie; Wang, Howard; Lipson, Michal; Bergman, Keren

    2011-01-01

    We introduce a multi-layer silicon photonic microring resonator filter, fabricated using deposited materials, and transmit up to 12.5-Gb/s error-free data, establishing a novel class of high-performance silicon photonics for advanced photonic NoCs. Furthermore, by leveraging deposited materials, we propose a novel fully-integrated scalable photonic switch architecture for data center networks, sustaining nonblocking 256×256 port size with nanosecond-scale switching times, interconnecting 2,560 server racks with 51.2-Tb/s bisection bandwidth.

  7. Statistical Image Processing.

    Science.gov (United States)

    1982-11-16

    spectral analysist texture image analysis and classification, __ image software package, automatic spatial clustering.ITWA domenit hi ba apa for...ICOLOR(256),IBW(256) 1502 FORMATO (30( CNO(N): fF12.1)) 1503 FORMAT(o *FMINo DMRGE:0f2E20.8) 1504 FORMAT(/o IMRGE:or15) 1505 FOR14ATV FIRST SUBIMAGE:v...1506 FORMATO ’ JOIN CLUSTER NL:0) 1507 FORMAT( NEW CLUSTER:O) 1508 FORMAT( LLBS.GE.600) 1532 FORMAT(15XoTHETA ,7X, SIGMA-SQUAREr3Xe MERGING-DISTANCE

  8. The charge pump PLL clock generator designed for the 1.56 ns bin size time-to-digital converter pixel array of the Timepix3 readout ASIC

    CERN Document Server

    Fu, Y et al.

    2014-01-01

    Timepix3 is a newly developed pixel readout chip which is expected to be operated in a wide range of gaseous and silicon detectors. It is made of 256×256 pixels organized in a square pixel-array with 55 µm pitch. Oscillators running at 640 MHz are distributed across the pixel-array and allow for a highly accurate measurement of the arrival time of a hit. This paper concentrates on a low-jitter phase locked loop (PLL) that is located in the chip periphery. This PLL provides a control voltage which regulates the actual frequency of the individual oscillators, allowing for compensation of process, voltage, and temperature variations.

  9. 1×4 Optical packet switching of variable length 640 Gbit/s data packets using in-band optical notch-filter labeling

    DEFF Research Database (Denmark)

    Medhin, Ashenafi Kiros; Kamchevska, Valerija; Galili, Michael;

    2014-01-01

    We experimentally perform 1×4 optical packet switching of variable length 640 Gbit/s OTDM data packets using in-band notch-filter labeling with only 2.7-dB penalty. Up to 8 notches are employed to demonstrate scalability of the labeling scheme to 1×256 switching operation.......We experimentally perform 1×4 optical packet switching of variable length 640 Gbit/s OTDM data packets using in-band notch-filter labeling with only 2.7-dB penalty. Up to 8 notches are employed to demonstrate scalability of the labeling scheme to 1×256 switching operation....

  10. Neutron Detector Signal Processing to Calculate the Effective Neutron Multiplication Factor of Subcritical Assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Talamo, Alberto [Argonne National Lab. (ANL), Argonne, IL (United States). Nuclear Engineering Division; Gohar, Yousry [Argonne National Lab. (ANL), Argonne, IL (United States). Nuclear Engineering Division

    2016-06-01

    This report describes different methodologies to calculate the effective neutron multiplication factor of subcritical assemblies by processing the neutron detector signals using MATLAB scripts. The subcritical assembly can be driven either by a spontaneous fission neutron source (e.g. californium) or by a neutron source generated from the interactions of accelerated particles with target materials. In the latter case, when the particle accelerator operates in a pulsed mode, the signals are typically stored into two files. One file contains the time when neutron reactions occur and the other contains the times when the neutron pulses start. In both files, the time is given by an integer representing the number of time bins since the start of the counting. These signal files are used to construct the neutron count distribution from a single neutron pulse. The built-in functions of MATLAB are used to calculate the effective neutron multiplication factor through the application of the prompt decay fitting or the area method to the neutron count distribution. If the subcritical assembly is driven by a spontaneous fission neutron source, then the effective multiplication factor can be evaluated either using the prompt neutron decay constant obtained from Rossi or Feynman distributions or the Modified Source Multiplication (MSM) method.

  11. On-line charge breeding using ECRIS and EBIS

    Science.gov (United States)

    Vondrasek, Richard

    2016-06-01

    The efficient and rapid production of a high-quality, pure beam of highly charged ions is at the heart of any radioactive ion beam facility. Whether an electron cyclotron resonance (ECR) ion source or an electron beam ion source (EBIS) is used to produce these highly charged ions, their operating characteristics will set the boundaries on the range of experiments which can be performed. In addition, time structure and duty cycle have to be considered when defining the operating parameters of the accelerator system as a whole. At Argonne National Laboratory (ANL), an ECR charge breeder was developed as part of the Californium Rare Ion Breeder Upgrade (CARIBU) program. The charge breeding efficiency and high charge state production of the source is at the forefront of ECR charge breeders, but its overall performance as part of the accelerator system is limited by pervasive background and relatively long breeding times. As such, an EBIS charge breeder has been developed and is running in an off-line configuration. It has already demonstrated good breeding efficiencies, shorter residence times, and reduced background and is scheduled to replace the ECR charge breeder in late 2015. The resultant change in duty cycle and time structure necessitates changes to the overall operation of the facility. The experiences with these breeders, as well as from several other facilities which already utilize an ECR or EBIS for charge breeding, help to define the operational characteristics of each technology - their strengths, their weaknesses, and the possible paths to improvement.

  12. γ -soft Ba146 and the role of nonaxial shapes at N90

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, A. J.; Lister, C. J.; McCutchan, E. A.; Albers, M.; Ayangeakaa, A. D.; Bertone, P. F.; Carpenter, M. P.; Chiara, C. J.; Chowdhury, P.; Clark, J. A.; Copp, P.; David, H. M.; Deo, A. Y.; DiGiovine, B.; D' Olympia, N.; Dungan, R.; Harding, R. D.; Harker, J.; Hota, S. S.; Janssens, R. V. F.; Kondev, F. G.; Liu, S. H.; Ramayya, A. V.; Rissanen, J.; Savard, G.; Seweryniak, D.; Shearman, R.; Sonzogni, A. A.; Tabor, S. L.; Walters, W. B.; Wang, E.; Zhu, S.

    2016-01-01

    Low-spin states in the neutron-rich, N=90 nuclide Ba146 were populated following β decay of Cs146, with the goal of clarifying the development of deformation in barium isotopes through delineation of their nonyrast structures. Fission fragments of Cs146 were extracted from a 1.7-Ci Cf252 source and mass selected using the CAlifornium Rare Ion Breeder Upgrade (CARIBU) facility. Low-energy ions were deposited at the center of a box of thin β detectors, surrounded by a highly efficient high-purity Ge array. The new Ba146 decay scheme now contains 31 excited levels extending up to ~2.5 MeV excitation energy, double what was previously known. These data are compared to predictions from the interacting boson approximation (IBA) model. It appears that the abrupt shape change found at N=90 in Sm and Gd is much more gradual in Ba and Ce, due to an enhanced role of the γ degree of freedom.

  13. Significant relationships among frost tolerance and net photosynthetic rate, water use efficiency and dehydrin accumulation in cold-treated winter oilseed rapes.

    Science.gov (United States)

    Urban, Milan Oldřich; Klíma, Miroslav; Vítámvás, Pavel; Vašek, Jakub; Hilgert-Delgado, Alois Albert; Kučera, Vratislav

    2013-12-15

    Five winter oilseed rape cultivars (Benefit, Californium, Cortes, Ladoga, Navajo) were subjected to 30 days of cold treatment (4 °C) to examine the effect of cold on acquired frost tolerance (FT), dehydrin (DHN) content, and photosynthesis-related parameters. The main aim of this study was to determine whether there are relationships between FT (expressed as LT50 values) and the other parameters measured in the cultivars. While the cultivar Benefit accumulated two types of DHNs (D45 and D35), the other cultivars accumulated three additional DHNs (D97, D47, and D37). The similar-sized DHNs (D45 and D47) were the most abundant; the others exhibited significantly lower accumulations. The highest correlations were detected between LT50 and DHN accumulation (r=-0.815), intrinsic water use efficiency (WUEi; r=-0.643), net photosynthetic rate (r=-0.628), stomatal conductance (r=0.511), and intracellular/intercellular CO2 concentration (r=0.505). Those cultivars that exhibited higher Pn rate in cold (and further a significant increase in WUEi) had higher levels of DHNs and also higher FT. No significant correlation was observed between LT50 and E, PRI, or NDVI. Overall, we have shown the selected physiological parameters to be able to distinguish different FT cultivars of winter oilseed rape.

  14. Studies of Beta-Delayed Neutron Emission using Trapped Ions

    Science.gov (United States)

    Siegl, Kevin; Aprahamian, A.; Scielzo, N. D.; Savard, G.; Clark, J. A.; Levand, A. F.; Burkey, M.; Caldwell, S.; Czeszumska, A.; Hirsh, T. Y.; Kolos, K.; Marley, S. T.; Morgan, G. E.; Norman, E. B.; Nystrom, A.; Orford, R.; Padgett, S.; Pérez Galván, A.; Sh, K. S.; Strauss, S. Y.; Wang, B. S.

    2017-01-01

    Using a radio-frequency quadrupole ion trap to confine radioactive ions allows indirect measurements of beta-delayed neutron (BDN) emission. By determining the recoil energy of the beta-decay daughter ions it is possible to study BDN emission, as the neutron emission can impart a significantly larger nuclear recoil than from beta-decay alone. This method avoids most of the systematic uncertainties associated with direct neutron detection but introduces dependencies on the specifics of the decay and interactions of the ion with the RF fields. The decays of seven BDN precursors were studied using the Beta-decay Paul Trap (BPT) to confine fission fragments from the Californium Rare Isotope Breeder Upgrade (CARIBU) facility at Argonne National Laboratory. The analysis of these measurements and results for the branching ratios and neutron energy spectra will be presented. Supported by the NSF under grant PHY-1419765, and the U.S. DOE under the NEUP project 13-5485, contracts DE-AC02-06CH11357 (ANL) and DE-AC52-07NA27344 (LLNL), and award DE-NA0000979 (NNSA).

  15. Production of Medical Radioisotopes in the ORNL High Flux Isotope Reactor (HFIR) for Cancer Treatment and Arterial Restenosis Therapy after PTCA

    Science.gov (United States)

    Knapp, F. F. Jr.; Beets, A. L.; Mirzadeh, S.; Alexander, C. W.; Hobbs, R. L.

    1998-06-01

    The High Flux Isotope Reactor (HFIR) at the Oak Ridge National Laboratory (ORNL) represents an important resource for the production of a wide variety of medical radioisotopes. In addition to serving as a key production site for californium-252 and other transuranic elements, important examples of therapeutic radioisotopes which are currently routinely produced in the HFIR for distribution include dysprosium-166 (parent of holmium-166), rhenium-186, tin-117m and tungsten-188 (parent of rhenium-188). The nine hydraulic tube (HT) positions in the central high flux region permit the insertion and removal of targets at any time during the operating cycle and have traditionally represented a major site for production of medical radioisotopes. To increase the irradiation capabilities of the HFIR, special target holders have recently been designed and fabricated which will be installed in the six Peripheral Target Positions (PTP), which are also located in the high flux region. These positions are only accessible during reactor refueling and will be used for long-term irradiations, such as required for the production of tin-117m and tungsten-188. Each of the PTP tubes will be capable of housing a maximum of eight HT targets, thus increasing the total maximum number of HT targets from the current nine, to a total of 57. In this paper the therapeutic use of reactor-produced radioisotopes for bone pain palliation and vascular brachytherapy and the therapeutic medical radioisotope production capabilities of the ORNL HFIR are briefly discussed.

  16. Extraction studies of selected actinide ions from aqueous solutions with 4-benzoyl-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-thione and tri-n-octylphosphine oxide

    Energy Technology Data Exchange (ETDEWEB)

    Hannink, N.J.; Hoffman, D.C. [Lawrence Berkeley Lab., CA (United States)]|[California Univ., Berkeley, CA (United States). Dept. of Chemistry; Smith, B.F. [Los Alamos National Lab., NM (United States)

    1991-11-01

    The first measurements of distribution coefficients (K{sub d}) for Cm(III), Bk(III), Cf(III), Es(III), and Fm(III) between aqueous perchlorate solutions and solutions of 4-benzoyl-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-thione (BMPPT) and the synergist tri-n-octylphosphine oxide (TOPO) in toluene are reported. Curium-243, berkelium-250, californium-249, einsteinium-254, and fermium-253 were used in these studies. The K{sub d} for {sup 241}Am was also measured and is in agreement with previously published results. Our new results show that the K{sub d}`s decrease gradually with increasing atomic number for the actinides with a dip at Cf. In general, the K{sub d}`s for these actinides are about a factor of 5 to 10 greater than the K{sub d}`s for the homologous lanthanides at a pH of 2.9, a BMPPT concentration of 0.2 M, and a TOPO concentration of 0.04 M. The larger K{sub d}`s for the actinides are consistent with greater covalent bonding between the actinide metal ion and the sulfur bonding site in the ligand.

  17. Extraction studies of selected actinide ions from aqueous solutions with 4-benzoyl-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-thione and tri-n-octylphosphine oxide

    Energy Technology Data Exchange (ETDEWEB)

    Hannink, N.J.; Hoffman, D.C. (Lawrence Berkeley Lab., CA (United States) California Univ., Berkeley, CA (United States). Dept. of Chemistry); Smith, B.F. (Los Alamos National Lab., NM (United States))

    1991-11-01

    The first measurements of distribution coefficients (K{sub d}) for Cm(III), Bk(III), Cf(III), Es(III), and Fm(III) between aqueous perchlorate solutions and solutions of 4-benzoyl-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-thione (BMPPT) and the synergist tri-n-octylphosphine oxide (TOPO) in toluene are reported. Curium-243, berkelium-250, californium-249, einsteinium-254, and fermium-253 were used in these studies. The K{sub d} for {sup 241}Am was also measured and is in agreement with previously published results. Our new results show that the K{sub d}'s decrease gradually with increasing atomic number for the actinides with a dip at Cf. In general, the K{sub d}'s for these actinides are about a factor of 5 to 10 greater than the K{sub d}'s for the homologous lanthanides at a pH of 2.9, a BMPPT concentration of 0.2 M, and a TOPO concentration of 0.04 M. The larger K{sub d}'s for the actinides are consistent with greater covalent bonding between the actinide metal ion and the sulfur bonding site in the ligand.

  18. Extraction studies of selected actinide ions from aqueous solutions with 4-benzoyl-2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-thione and Tri-n-octylphosphine oxide

    Energy Technology Data Exchange (ETDEWEB)

    Hannink, N.J.; Hoffman, D.C. [Lawrence Berkeley Lab., CA (United States); Smith, B.F. [Los Alamos National Lab., NM (United States)

    1992-07-01

    The first measurements of distribution coefficients (k{sub d}) for Cm(III), Bk(III), Cf(III), Es(III), and Fm(III) between aqueous perchlorate solutions and solutions of 4-benzoyl-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-thione (BMPPT) and the synergist tri-n-octylphosphine oxide (TOPO) in toluene are reported. Curium-243, berkelium-250, californium-249, einsteinium-254, and fermium-253 were used in these studies. The K{sub d} for {sup 241}Am was also measured and is in agreement with previously published results. Our new results show that the K{sub d}`s decrease gradually with increasing atomic number for the actinides with a dip at Cf. In general, the K{sub d}`s for these actinides are about about a factor of 10 greater than the K{sub d}`s for the homologous lanthanides at a pH of 2.9, a BMPPT concentration of 0.2 M, and a TOPO concentration of 0.04 M. The larger K{sub d}`s for the actinides are consistent with greater covalent bonding between the actinide metal ion and the sulfur bonding site in the ligand. 9 refs., 2 figs., 1 tab.

  19. Recovery and chemical purification of actinides at JRC, Karlsruhe

    Science.gov (United States)

    Bokelund, H.; Apostolidis, C.; Glatz, J.-P.

    1989-07-01

    The application of actinide elements in research and in technology is many times subject to rather stringent purity requirements; often a nuclear grade quality is specified. The additional possible demand for a high isotopic purity is a special feature in the handling of these elements. The amount of actinide elements contained in or adhering to materials declared as waste should be low for safety reasons and out of economic considerations. The release of transuranium elements to the environment must be kept negligible. For these and for other reasons a keen interest in the separation of actinides from various materials exists, either for a re-use through recycling, or for their safe confinement in waste packages. This paper gives a short review of the separation methods used for recovery and purification of actinide elements over the past years in the European Institute for Transuranium Elements. The methods described here involve procedures based on precipitation, ion exchange or solvent extraction; often used in a combination. The extraction methods were preferably applied in a Chromatographie column mode. The actinide elements purified and/or separated from each other by the above methods include uranium, neptunium, plutonium, americium, curium, and californium. For the various elements the work was undertaken with different aims, ranging from reprocessing and fabrication of nuclear fuels on a kilogramme scale, over the procurement of alpha-free waste, to the preparation of neutron sources of milligramme size.

  20. Production of medical radioisotopes in the ORNL High Flux Isotope Reactor (HFIR) for cancer treatment and arterial restenosis therapy after PTCA

    Energy Technology Data Exchange (ETDEWEB)

    Knapp, F.F. Jr.; Beets, A.L.; Mirzadeh, S.; Alexander, C.W.; Hobbs, R.L.

    1998-06-01

    The High Flux Isotope Reactor (HFIR) at the Oak Ridge National Laboratory (ORNL) represents an important resource for the production of a wide variety of medical radioisotopes. In addition to serving as a key production site for californium-252 and other transuranic elements, important examples of therapeutic radioisotopes which are currently routinely produced in the HFIR for distribution include dysprosium-166 (parent of holmium-166), rhenium-186, tin-117m and tungsten-188 (parent of rhenium-188). The nine hydraulic tube (HT) positions in the central high flux region permit the insertion and removal of targets at any time during the operating cycle and have traditionally represented a major site for production of medical radioisotopes. To increase the irradiation capabilities of the HFIR, special target holders have recently been designed and fabricated which will be installed in the six Peripheral Target Positions (PTP), which are also located in the high flux region. These positions are only accessible during reactor refueling and will be used for long-term irradiations, such as required for the production of tin-117m and tungsten-188. Each of the PTP tubes will be capable of housing a maximum of eight HT targets, thus increasing the total maximum number of HT targets from the current nine, to a total of 57. In this paper the therapeutic use of reactor-produced radioisotopes for bone pain palliation and vascular brachytherapy and the therapeutic medical radioisotope production capabilities of the ORNL HFIR are briefly discussed.

  1. Compensated bismuth-loaded plastic scintillators for neutron detection using low-energy pseudo-spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Dumazert, Jonathan, E-mail: jonathan.dumazert@cea.fr [CEA, LIST, Laboratoire Capteurs Architectures Electroniques, 91191 Gif-sur-Yvette (France); Coulon, Romain; Bertrand, Guillaume H.V.; Normand, Stéphane [CEA, LIST, Laboratoire Capteurs Architectures Electroniques, 91191 Gif-sur-Yvette (France); Méchin, Laurence [CNRS, UCBN, Groupe de Recherche en Informatique, Image, Automatique et Instrumentation de Caen, 14050 Caen (France); Hamel, Matthieu [CEA, LIST, Laboratoire Capteurs Architectures Electroniques, 91191 Gif-sur-Yvette (France)

    2016-05-21

    Gadolinium-covered modified plastic scintillators show a high potential for the deployment of cost-effective neutron detectors. Taking advantage of the low-energy photon and electron signature of thermal neutron captures in gadolinium-155 and gadolinium-157 however requires a background correction. In order to display a trustable rate, dual compensation schemes appear as an alternative to Pulse Shape Discrimination. This paper presents the application of such a compensation scheme to a two-bismuth loaded plastic scintillator system. A detection scintillator interacts with incident photon and fast neutron radiations and is covered with a gadolinium converter to become thermal neutron-sensitive as well. In the meantime, an identical compensation scintillator, covered with terbium, solely interacts with the photon and fast neutron part of incident radiations. After the acquisition and the treatment of the counting signals from both sensors, a hypothesis test determines whether the resulting count rate after subtraction falls into statistical fluctuations or provides a robust image of neutron activity. A laboratory prototype is tested under both photon and neutron radiations, allowing us to investigate the performance of the overall compensation system. The study reveals satisfactory results in terms of robustness to a cesium-137 background and in terms of sensitivity in presence of a californium-252 source.

  2. Fast neutron tomography with real-time pulse-shape discrimination in organic scintillation detectors

    Science.gov (United States)

    Joyce, Malcolm J.; Agar, Stewart; Aspinall, Michael D.; Beaumont, Jonathan S.; Colley, Edmund; Colling, Miriam; Dykes, Joseph; Kardasopoulos, Phoevos; Mitton, Katie

    2016-10-01

    A fast neutron tomography system based on the use of real-time pulse-shape discrimination in 7 organic liquid scintillation detectors is described. The system has been tested with a californium-252 source of dose rate 163 μSv/h at 1 m and neutron emission rate of 1.5×107 per second into 4π and a maximum acquisition time of 2 h, to characterize two 100×100×100 mm3 concrete samples. The first of these was a solid sample and the second has a vertical, cylindrical void. The experimental data, supported by simulations with both Monte Carlo methods and MATLAB®, indicate that the presence of the internal cylindrical void, corners and inhomogeneities in the samples can be discerned. The potential for fast neutron assay of this type with the capability to probe hydrogenous features in large low-Z samples is discussed. Neutron tomography of bulk porous samples is achieved that combines effective penetration not possible with thermal neutrons in the absence of beam hardening.

  3. A review of neutron scattering correction for the calibration of neutron survey meters using the shadow cone method

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sang In; Kim, Bong Hwan; Kim, Jang Lyul; Lee, Jung Il [Health Physics Team, Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-12-15

    The calibration methods of neutron-measuring devices such as the neutron survey meter have advantages and disadvantages. To compare the calibration factors obtained by the shadow cone method and semi-empirical method, 10 neutron survey meters of five different types were used in this study. This experiment was performed at the Korea Atomic Energy Research Institute (KAERI; Daejeon, South Korea), and the calibration neutron fields were constructed using a {sup 252}Californium ({sup 252}Cf) neutron source, which was positioned in the center of the neutron irradiation room. The neutron spectra of the calibration neutron fields were measured by a europium-activated lithium iodide scintillator in combination with KAERI's Bonner sphere system. When the shadow cone method was used, 10 single moderator-based survey meters exhibited a smaller calibration factor by as much as 3.1 - 9.3% than that of the semi-empirical method. This finding indicates that neutron survey meters underestimated the scattered neutrons and attenuated neutrons (i.e., the total scatter corrections). This underestimation of the calibration factor was attributed to the fact that single moderator-based survey meters have an under-ambient dose equivalent response in the thermal or thermal-dominant neutron field. As a result, when the shadow cone method is used for a single moderator-based survey meter, an additional correction and the International Organization for Standardization standard 8529-2 for room-scattered neutrons should be considered.

  4. Active Neutron Interrogation of Non-Radiological Materials with NMIS

    Energy Technology Data Exchange (ETDEWEB)

    Walker, Mark E [ORNL; Mihalczo, John T [ORNL

    2012-02-01

    The Nuclear Materials Identification System (NMIS) at Oak Ridge National Laboratory (ORNL), although primarily designed for analyzing special nuclear material, is capable of identifying nonradiological materials with a wide range of measurement techniques. This report demonstrates four different measurement methods, complementary to fast-neutron imaging, which can be used for material identification: DT transmission, DT scattering, californium transmission, and active time-tagged gamma spectroscopy. Each of the four techniques was used to evaluate how these methods can be used to identify four materials: aluminum, polyethylene, graphite, and G-10 epoxy. While such measurements have been performed individually in the past, in this project, all four measurements were performed on the same set of materials. The results of these measurements agree well with predicted results. In particular, the results of the active gamma spectroscopy measurements demonstrate the technique's applicability in a future version of NMIS which will incorporate passive and active gamma-ray spectroscopy. This system, designated as a fieldable NMIS (FNMIS), is under development by the US Department of Energy Office of Nuclear Verification.

  5. X-ray Measurements of a Thermo Scientific P385 DD Neutron Generator

    Energy Technology Data Exchange (ETDEWEB)

    E.H. Seabury; D.L. Chichester; A.J. Caffrey; J. Simpson; M. Lemchak; C.J. Wharton

    2001-08-01

    Idaho National Laboratory is experimenting with electrical neutron generators, as potential replacements for californium-252 radioisotopic neutron sources in its PINS prompt gamma-ray neutron activation analysis (PGNAA) system for the identification of military chemical warfare agents and explosives. In addition to neutron output, we have recently measured the x-ray output of the Thermo Scientific P385 deuterium-deuterium neutron generator. X-rays are a normal byproduct from a neutron generator and depending on their intensity and energy they can interfere with gamma rays from the object under test, increase gamma-spectrometer dead time, and reduce PGNAA system throughput. The P385 x-ray energy spectrum was measured with a high-purity germanium (HPGe) detector, and a broad peak is evident at about 70 keV. To identify the source of the x-rays within the neutron generator assembly, it was scanned by collimated scintillation detectors along its long axis. At the strongest x-ray emission points, the generator also was rotated 60° between measurements. The scans show the primary source of x-ray emission from the P385 neutron generator is an area 60 mm from the neutron production target, in the vicinity of the ion source. Rotation of the neutron generator did not significantly alter the x-ray count rate, and the x-ray emission appears to be axially symmetric within the neutron generator.

  6. An Account of Oak Ridge National Laboratory's Thirteen Research Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Rosenthal, Murray Wilford [ORNL

    2009-08-01

    The Oak Ridge National Laboratory has built and operated 13 nuclear reactors in its 66-year history. The first was the graphite reactor, the world's first operational nuclear reactor, which served as a plutonium production pilot plant during World War II. It was followed by two aqueous-homogeneous reactors and two red-hot molten-salt reactors that were parts of power-reactor development programs and by eight others designed for research and radioisotope production. One of the eight was an all-metal fast burst reactor used for health physics studies. All of the others were light-water cooled and moderated, including the famous swimming-pool reactor that was copied dozens of times around the world. Two of the reactors were hoisted 200 feet into the air to study the shielding needs of proposed nuclear-powered aircraft. The final reactor, and the only one still operating today, is the High Flux Isotope Reactor (HFIR) that was built particularly for the production of californium and other heavy elements. With the world's highest flux and recent upgrades that include the addition of a cold neutron source, the 44-year-old HFIR continues to be a valuable tool for research and isotope production, attracting some 500 scientific visitors and guests to Oak Ridge each year. This report describes all of the reactors and their histories.

  7. Test and evaluation results of the /sup 252/Cf shuffler at the Savannah River Plant

    Energy Technology Data Exchange (ETDEWEB)

    Crane, T.W.

    1981-03-01

    The /sup 252/Cf Shuffler, a nondestructive assay instrument employing californium neutron source irradiation and delayed-neutron counting, was developed for measuring /sup 235/U content of scrap and waste items generated at the Savannah River Plant (SRP) reactor fuel fabrication facility. The scrap and waste items include high-purity uranium-aluminum alloy ingots as well as pieces of castings, saw and lathe chips from machining operations, low-purity items such as oxides of uranium or uranium intermixed with flux materials found in recovery operations, and materials not recoverable at SRP such as floor sweepings or residues from the uranium scrap recovery operation. The uranium contains about 60% /sup 235/U with the remaining isotopes being /sup 236/U, /sup 238/U, and /sup 234/U in descending order. The test and evaluation at SRP concluded that the accuracy, safety, reliability, and ease of use made the /sup 252/Cf Shuffler a suitable instrument for routine use in an industrial, production-oriented plant.

  8. Compensated bismuth-loaded plastic scintillators for neutron detection using low-energy pseudo-spectroscopy

    Science.gov (United States)

    Dumazert, Jonathan; Coulon, Romain; Bertrand, Guillaume H. V.; Normand, Stéphane; Méchin, Laurence; Hamel, Matthieu

    2016-05-01

    Gadolinium-covered modified plastic scintillators show a high potential for the deployment of cost-effective neutron detectors. Taking advantage of the low-energy photon and electron signature of thermal neutron captures in gadolinium-155 and gadolinium-157 however requires a background correction. In order to display a trustable rate, dual compensation schemes appear as an alternative to Pulse Shape Discrimination. This paper presents the application of such a compensation scheme to a two-bismuth loaded plastic scintillator system. A detection scintillator interacts with incident photon and fast neutron radiations and is covered with a gadolinium converter to become thermal neutron-sensitive as well. In the meantime, an identical compensation scintillator, covered with terbium, solely interacts with the photon and fast neutron part of incident radiations. After the acquisition and the treatment of the counting signals from both sensors, a hypothesis test determines whether the resulting count rate after subtraction falls into statistical fluctuations or provides a robust image of neutron activity. A laboratory prototype is tested under both photon and neutron radiations, allowing us to investigate the performance of the overall compensation system. The study reveals satisfactory results in terms of robustness to a cesium-137 background and in terms of sensitivity in presence of a californium-252 source.

  9. Measurement of neutron dose and spectra at light-water reactors

    Energy Technology Data Exchange (ETDEWEB)

    Soldat, K.L.; Endres, G.W.R.; Cummings, F.M.

    1982-08-01

    In choosing one dosimeter over another, both sensitivity and precision must be addressed. It has been determined that dosimeters employing NTA film lack adequate sensitivity for use inside containment of nuclear plants. From this study, it is apparent that CR-39 and polycarbonate track etch films used without radiators are also inadequate. The rest of the dosimeters tested displayed adequate sensitivity. The two general types of dosimeters which comprise that group are: (1) TLDs and (2) the polycarbonate track etch which was used in conjunction with (n, ..cap alpha..) radiators. The precision of the TLD dosimeter depends on the calibration technique and response correction technique. TLD dosimeters calibrated to D/sub 2/O-moderated californium-252 or corrected based on 9- to 3-in. sphere response rates seemed to function best inside reactor containment. Polycarbonate track etch film with (n, ..cap alpha..) radiators was found to be sensitive enough for use inside reactor containment; however, the standard deviation for the results was roughly twice the value of the most precise TLD albedo dosimeters. Also, several of the polycarbonate dosimeters saturated, rendering any evaluation impossible.

  10. Report on the workshop "Decay spectroscopy at CARIBU: advanced fuel cycle applications, nuclear structure and astrophysics". 14-16 April 2011, Argonne National Laboratory, USA.

    Energy Technology Data Exchange (ETDEWEB)

    Kondev, F.; Carpenter, M.P.; Chowdhury, P.; Clark, J.A.; Lister, C.J.; Nichols, A.L.; Swewryniak, D. (Nuclear Engineering Division); (Univ. of Massachusetts); (Univ. of Surrey)

    2011-10-06

    A workshop on 'Decay Spectroscopy at CARIBU: Advanced Fuel Cycle Applications, Nuclear Structure and Astrophysics' will be held at Argonne National Laboratory on April 14-16, 2011. The aim of the workshop is to discuss opportunities for decay studies at the Californium Rare Isotope Breeder Upgrade (CARIBU) of the ATLAS facility with emphasis on advanced fuel cycle (AFC) applications, nuclear structure and astrophysics research. The workshop will consist of review and contributed talks. Presentations by members of the local groups, outlining the status of relevant in-house projects and availabile equipment, will also be organized. time will also be set aside to discuss and develop working collaborations for future decay studies at CARIBU. Topics of interest include: (1) Decay data of relevance to AFC applications with emphasis on reactor decay heat; (2) Discrete high-resolution gamma-ray spectroscopy following radioactive decya and related topics; (3) Calorimetric studies of neutron-rich fission framgents using Total ABsorption Gamma-Ray Spectrometry (TAGS) technique; (4) Beta-delayed neutron emissions and related topics; and (5) Decay data needs for nuclear astrophysics.

  11. Neutron activation determination of gold in technogenic raw materials with different mineral composition

    Directory of Open Access Journals (Sweden)

    Yudakov Aleksandr A.

    2015-01-01

    Full Text Available The methods used to determine the gold content in the technogenic objects of gold mining were analyzed regarding their non-homogeneity and complexity of chemical and mineral compositions. A possible application of the neutron activation analysis with the use of the californium source of neutrons for determining the content of fine-grained and extra-fine-grained gold in the technogenic objects, including the bottom-ash waste of energy providers, is considered. It was demonstrated that the chemical composition of the sample affects the neuron flux distribution in the sample, which can essentially distort the results of the neutron activation analysis. In order to eliminate possible systematic errors investigations of the effect of the sample mineral composition on the results of the gold determination using the neutron activation analysis were carried out. Namely, a large mass of rock (3-5 kg was loaded into an activation zone using four matrix types such as silicate, carbon-containing, iron-containing, and titanium magnetite. It was shown that there wereno significant difference between the dispersal of the fluxes of thermal and resonance neutrons emitted from 252Cf during activation of the gold-containing technogenic samples with different mineral compositions.

  12. Occurrence of Ehrlichia canis and Anaplasma platys in household dogs from northern Parana.

    Science.gov (United States)

    da Silva, Gislaine Cristina Ferreira; Benitez, Aline do Nascimento; Girotto, Aline; Taroda, Alessandra; Vidotto, Marilda Carlos; Garcia, João Luis; de Freitas, Julio Cesar; Arlington, Selwyn Headley; Vidotto, Odilon

    2012-01-01

    Canine monocytic ehrlichiosis caused primarily by Ehrlichia canis and canine thrombocytic anaplasmosis induced by Anaplasma platys are important emerging zoonotic tick-borne diseases of dogs. There is evidence that these pathogens can also affect humans. This study evaluated the presence of E. canis and A. platys in blood samples collected from 256 domiciled dogs in the municipality of Jataizinho, located in north region of the State of Parana, Brazil, by PCR assay. The occurrence of E. canis and A. platys was 16.4% (42/256) and 19.4% (49/256), respectively; while 5.47% (14/256) of the dogs evaluated were co-infected by these two organisms. The presence of E. canis and A. platys was not significantly associated with the variables evaluated (sex, age, outdoor access, and presence of ticks during blood collection). Infection of dogs by E. canis was associated with anemia and thrombocytopenia, while infection induced by A. platys was related only to thrombocytopenia. Canine monocytic ehrlichiosis and canine thrombocytic anaplasmosis should be included in the differential diagnoses when these hematological alterations are observed during routine laboratory evaluation of dogs.

  13. Promoting healthy eating to children

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino; Grønhøj, Alice

    2013-01-01

    The paper presents the design and results of a goal-setting and feedback intervention aimed at increasing consumption of fruits and vegetables. The intervention involved 256 Danish adolescents (aged 12), and consisted of a nutrition education programme and an SMS-based diary and feedback procedur...

  14. 78 FR 44016 - Exclusion of Orphan Drugs for Certain Covered Entities Under 340B Program

    Science.gov (United States)

    2013-07-23

    ... HUMAN SERVICES 42 CFR Part 10 RIN 0906-AA94 Exclusion of Orphan Drugs for Certain Covered Entities Under... exclusion requirements. This rule will provide clarity in the marketplace, maintain the 340B savings for... 340B(e) of the PHSA (42 U.S.C. 256b(e)) states the following: EXCLUSION OF ORPHAN DRUGS FOR...

  15. Nurses' Motivations for Web-Based Learning and the Role of Internet Self-Efficacy

    Science.gov (United States)

    Liang, Jyh-Chong; Wu, Szu-Hsien

    2010-01-01

    The purpose of this study was to investigate clinical nurses' Internet self-efficacy and motivations toward Web-based learning. The sample consisted of 256 volunteer nurses from one selected medical centre in Taiwan. This study used the Internet Self-efficacy Survey (ISS) and the Motivations about Web-based Continuing Learning Survey (MWCL) for…

  16. Polymorphous Computing Architecture (PCA) Kernel Benchmark Measurements on the MIT Raw Microprocessor

    Science.gov (United States)

    2006-06-14

    grammer . The term "static" applied to the networks implies that the programmer must set up the communication pattern used by the switch in advance of...length of 256 using the I x-l Raw Handheld Board. The total chip throughput is based on parallel FIR filters teach side of the chip performs a FIR

  17. The Effects of Transformational Leadership and the Sense of Calling on Job Burnout among Special Education Teachers

    Science.gov (United States)

    Gong, Tao; Zimmerli, Laurie; Hoffer, Harry E.

    2013-01-01

    This article examines the effects of transformational leadership of supervisors and the sense of calling on job burnout among special education teachers. A total of 256 special education teachers completed the Maslach Burnout Inventory and rated their supervisors on the Multifactor Leadership Questionnaire. The results reveal that transformational…

  18. 77 FR 16058 - Willapa National Wildlife Refuge, Pacific County, WA; Record of Decision for Final Environmental...

    Science.gov (United States)

    2012-03-19

    ... conservation purposes. It encompasses over 16,000 acres of tidelands, temperate rainforest, ocean beaches, sand... establishing the early-blue violet host plant on 33 acres, which will serve the future reintroduction of the... Bend, WA 98586. Ocean Park Timberland Library, 1308 256th Place, Ocean Park, WA 98640. Astoria...

  19. 76 FR 40903 - Grand River Dam Authority; Notice of Application for Amendment of License and Soliciting Comments...

    Science.gov (United States)

    2011-07-12

    ... Energy Regulatory Commission Grand River Dam Authority; Notice of Application for Amendment of License...: Grand River Dam Authority. e. Name of Project: Salina Pumped Storage Project. f. Location: The project... River Dam Authority, P.O. Box 409, Vinita, OK 73401-0409. Tel: (918) 256-5545. i. FERC Contact:...

  20. 77 FR 30518 - Grand River Dam Authority; Notice of Application for Amendment of License and Soliciting Comments...

    Science.gov (United States)

    2012-05-23

    ... Energy Regulatory Commission Grand River Dam Authority; Notice of Application for Amendment of License... 11, 2012. d. Applicant: Grand River Dam Authority. e. Name of Project: Pensacola Hydroelectric... Counsel, Grand River Dam Authority, P.O. Box 409, Vinita, Oklahoma 74301, (918) 256-5545. i. FERC...

  1. 76 FR 7831 - Grand River Dam Authority; Notice of Application for Amendment of License and Soliciting Comments...

    Science.gov (United States)

    2011-02-11

    ... Energy Regulatory Commission Grand River Dam Authority; Notice of Application for Amendment of License...: Grand River Dam Authority. e. Name of Project: Markham Ferry Project. f. Location: The project is..., Grand River Dam Authority, P.O. Box 409, Vinita, OK 73401-0409. Tel: (918) 256-5545. i. FERC...

  2. 78 FR 30914 - Grand River Dam Authority Notice of Application for Temporary Variance of License and Soliciting...

    Science.gov (United States)

    2013-05-23

    ... Federal Energy Regulatory Commission Grand River Dam Authority Notice of Application for Temporary...: March 20, 2013, and supplemented on May 3, 2013, and May 16, 2013. d. Applicant: Grand River Dam..., Grand River Dam Authority, P.O. Box 409, Vinita, OK 74301; telephone: (918) 256-5545. i. FERC Contact:...

  3. Removal and fate of Cryptosporidium parvum, Clostridium perfringens and small-sized centric diatoms (Stephanodiscus hantzschii) in slow sand filters

    NARCIS (Netherlands)

    Hijnen, W.A.M.; Dullemont, Y.J.; Schijven, J.F.; Brouwer-Hanzens, Anke J.; Rosielle, M.; Medema, Gerriet Jan

    2007-01-01

    The decimal elimination capacity (DEC) of slow sand filtration (SSF) for Cryptosporidium parvum was assessed to enable quantitative microbial risk analysis of a drinking water production plant. A mature pilot plant filter of 2.56 m2 was loaded with C. parvum oocysts and two other persistent organism

  4. The Structure and Development of Dispositional Compassion in Early Adolescence

    Science.gov (United States)

    Bengtsson, Hans; Söderström, Micael; Terjestam, Yvonne

    2016-01-01

    Compassion may be directed at a broad range of targets. The present study investigated interrelations among other-directed compassion, self-compassion, and environmental compassion in early adolescence (age = 12-14; n = 256) and examined how the different manifestations of compassion related to age and sex during this age period. Dispositional…

  5. A Chip for an Implantable Neural Stimulator

    DEFF Research Database (Denmark)

    Gudnason, Gunnar; Bruun, Erik; Haugland, Morten

    2000-01-01

    transmission to the stimulator passes through a 5 MHz inductive link. From the signals transmitted to the stimulator, the chip is able to generate charge-balanced current pulses with a controllable length up to 256 µs and an amplitude up to 2 mA, for stimulation of nerve fibers. The quiescent current...

  6. Microbiological quality of water from hand-dug wells used for domestic purposes in urban communities in Kumasi, Ghana

    DEFF Research Database (Denmark)

    Akple, M.; Keraita, Bernard; Konradsen, Flemming

    2011-01-01

    Assessment was done on the microbiological quality of water in hand-dug wells in urban communities in Kumasi, Ghana. A total of 256 water samples were taken from eight wells and examined for faecal coliforms, enterococci and helminths. High contamination levels were recorded in the wells, more so...

  7. Modeling Longitudinal Changes in 5m Sprinting Performance Among Young Male Tennis Players

    NARCIS (Netherlands)

    Kramer, Tamara; Valente-Dos-Santos, Joao; Coelho-E-Silva, Manuel J.; Malina, Robert M.; Huijgen, Barbara C. H.; Smith, Joanne; Elferink-Gemser, Marije T.; Visscher, Chris

    2016-01-01

    Year-to-year changes in sprinting in youth tennis players were examined in a mixed-longitudinal study (256 male players, aged 10-15 years: 993 measurements). Height (h), body mass (BM), lower limb explosive strength (LLES), and a 5-m sprint were measured over five years. During that period, players

  8. LIP5 interacts with aquaporin 2 and facilitates its lysosomal degradation.

    NARCIS (Netherlands)

    Balkom, B.W.M. van; Boone, M.; Hendriks, G.; Kamsteeg, E.J.; Robben, J.H.; Stronks, H.C.; Voorde, A. van der; Herp, F. van; Sluijs, P. van der; Deen, P.M.T.

    2009-01-01

    Vasopressin binding to the V2 receptor in renal principal cells leads to activation of protein kinase A, phosphorylation of aquaporin 2 (AQP2) at Ser256, and the translocation of AQP2 to the apical membrane, resulting in concentration of the urine. In contrast, phorbol ester-induced activation of pr

  9. Adaptive Patterns of Stress Responsivity: A Preliminary Investigation

    Science.gov (United States)

    Del Giudice, Marco; Hinnant, J. Benjamin; Ellis, Bruce J.; El-Sheikh, Mona

    2012-01-01

    The adaptive calibration model (ACM) is an evolutionary-developmental theory of individual differences in stress responsivity. In this article, we tested some key predictions of the ACM in a middle childhood sample (N = 256). Measures of autonomic nervous system activity across the sympathetic and parasympathetic branches validated the 4-pattern…

  10. A validation study of the Brief Irrational Thoughts Inventory

    NARCIS (Netherlands)

    L.M. Hoogsteder; I.B. Wissink; G.J.J.M. Stams; J.E. van Horn; J. Hendriks

    2014-01-01

    This study examines the reliability and validity of the "Brief Irrational Thoughts Inventory" (BITI) in a sample of 256 justice-involved youths. The BITI is a questionnaire used to determine the nature and severity of irrational thoughts related to aggressive (externalizing), sub-assertive (internal

  11. Depression and College Stress among University Undergraduates: Do Mattering and Self-Esteem Make a Difference?

    Science.gov (United States)

    Dixon, Sarah K.; Kurpius, Sharon E. Robinson

    2008-01-01

    Depression and college stress, major concerns among undergraduates, are potentially related to self-esteem and mattering. This study investigated the interrelationships among these four variables. Participants included college students (199 males and 256 females) between the ages of 18 and 23. Significant sex differences were found with women…

  12. 8 CFR 1280.6 - Bond to obtain clearance; form.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Bond to obtain clearance; form. 1280.6... IMMIGRATION REGULATIONS IMPOSITION AND COLLECTION OF FINES § 1280.6 Bond to obtain clearance; form. A bond to obtain clearance of a vessel or aircraft under section 231, 237, 239, 243, 251, 253, 254, 255, 256,...

  13. 75 FR 6360 - Information on Surplus Land at a Military Installation Designated for Disposal: Newport Naval...

    Science.gov (United States)

    2010-02-09

    ... surface areas (i.e. parking areas, sidewalks, etc). (7) Utility facilities (approximately 2 structures... concrete underground fuel storage tanks (2.56 million-gallon capacity), 6 steel underground fuel storage... capacity), 1 underground water tank (1 million-gallon capacity), and 3 support facilities (22,738...

  14. A forensic and phylogenetic survey of Caulerpa species (Caulerpales, Chlorophyta) from the Florida coast, local aquarium shops, and e-commerce : Establishing a proactive baseline for early detection

    NARCIS (Netherlands)

    Stam, Wytze T.; Olsen, Jeanine L.; Zaleski, Susan Frisch; Murray, Steven N.; Brown, Katherine R.; Walters, Linda J.

    2006-01-01

    Baseline genotypes were established for 256 individuals of Caulerpa collected from 27 field locations in Florida (including the Keys), the Bahamas, US Virgin Islands, and Honduras, nearly doubling the number of available GenBank sequences. On the basis of sequences from the nuclear rDNA-ITS 1+2 and

  15. Geographic Mobility as Seen by the Wife and Mother

    Science.gov (United States)

    Jones, Stella B.

    1973-01-01

    This paper summarizes the responses of 256 women to a questionnaire which focused on their recent experiences in the process of moving with their families. Typically they are happy with the new community and with the personality changes which have occured as a result of their moving experiences. (Author)

  16. Deaf Adults' Reasons for Genetic Testing Depend on Cultural Affiliation: Results from a Prospective, Longitudinal Genetic Counseling and Testing Study

    Science.gov (United States)

    Boudreault, Patrick; Baldwin, Erin E.; Fox, Michelle; Dutton, Loriel; Tullis, LeeElle; Linden, Joyce; Kobayashi, Yoko; Zhou, Jin; Sinsheimer, Janet S.; Sininger, Yvonne; Grody, Wayne W.; Palmer, Christina G. S.

    2010-01-01

    This article examines the relationship between cultural affiliation and deaf adults' motivations for genetic testing for deafness in the first prospective, longitudinal study to examine the impact of genetic counseling and genetic testing on deaf adults and the deaf community. Participants (n = 256), classified as affiliating with hearing, Deaf,…

  17. Phenotype-gene: 58 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 58 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1057i decreased efficiency...17(2):256-68. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u12533513i decreased efficiency durin

  18. Domain Modeling: NP_001002912.3 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_001002912.3 chr1 CRYSTAL STRUCTURE OF TROPOMYOSIN AT 7 ANGSTROMS RESOLUTION IN T...HE SPERMINE-INDUCED CRYSTAL FORM c1c1gd_ chr1/NP_001002912.3/NP_001002912.3_apo_256-533.pdb psi-blast 0 ...

  19. Automatic Measurement of Particles from Holograms Taken in the Combustion Chamber of a Rocket Motor

    Science.gov (United States)

    1988-12-01

    properties that are very important in this speckle reduction, the resolution and the processing speed. Both aspects were improved a great deal since...RPIXEL((I-1),(J-1)) 40 CONTINUE 30 CONTINUE 20 CONTINUE ’*** DEVIDE EACH PIXEL VALUE BY THE NUMBER OF IMAGES (NOI) *********** DO 50 K - 1,256 DO 60

  20. Comparative Policy Brief: Status of Intellectual Disabilities in the Republic of Zambia

    Science.gov (United States)

    Mung'omba, James

    2008-01-01

    In the Republic of Zambia, an estimated 256,000 persons have some form of disability, and of these, 5.4% have intellectual disabilities. Even now, traditional beliefs about the etiology of intellectual disabilities persist and considerable stigma is attached to the presence of persons with intellectual disabilities who are often excluded from…

  1. Basic Studies on Electro-Energetic Physics (EEP) Weapons Technologies

    Science.gov (United States)

    2015-01-15

    Po\\\\ered Microwa\\e. High Energ) Laser. Charged Particle Beams. and II) pcrsonic Rail guns . Using these representations. wargame simulations of’ arious...weaponry, it is illustrating to compare these figures with the M-1 Abrams M256 120mm gun firing a M829A1 kinetic energy round Page 5 • Muzzle

  2. Climate science: The history of Greenland's ice

    Science.gov (United States)

    Blard, Pierre-Henri; Leduc, Guillaume; Glasser, Neil

    2016-12-01

    Global sea levels would rise by several metres if the Greenland Ice Sheet melted completely. Two studies have examined its past behaviour in an effort to evaluate its vulnerability in a warming world -- and have come to seemingly conflicting conclusions. Two geochemists and a glaciologist discuss the issues. See Letters p.252 & p.256

  3. Effect of spatial noise of medical grade Liquid Crystal Displays (LCD) on the detection of micro-calcification

    Science.gov (United States)

    Roehrig, Hans; Fan, Jiahua; Dallas, William J.; Krupinski, Elizabeth A.; Johnson, Jeffrey

    2009-08-01

    This presentation describes work in progress that is the result of an NIH SBIR Phase 1 project that addresses the wide- spread concern for the large number of breast-cancers and cancer victims [1,2]. The primary goal of the project is to increase the detection rate of microcalcifications as a result of the decrease of spatial noise of the LCDs used to display the mammograms [3,4]. Noise reduction is to be accomplished with the aid of a high performance CCD camera and subsequent application of local-mean equalization and error diffusion [5,6]. A second goal of the project is the actual detection of breast cancer. Contrary to the approach to mammography, where the mammograms typically have a pixel matrix of approximately 1900 x 2300 pixels, otherwise known as FFDM or Full-Field Digital Mammograms, we will only use sections of mammograms with a pixel matrix of 256 x 256 pixels. This is because at this time, reduction of spatial noise on an LCD can only be done on relatively small areas like 256 x 256 pixels. In addition, judging the efficacy for detection of breast cancer will be done using two methods: One is a conventional ROC study [7], the other is a vision model developed over several years starting at the Sarnoff Research Center and continuing at the Siemens Corporate Research in Princeton NJ [8].

  4. Gclust Server: 10014 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 10014 DKLA_KLLA0A11462g Cluster Sequences Related Sequences(7) 256 - 11 1.00e-06 14....29 33.33 0.0 0.0 0.0 62.5 Show 10014 Cluster ID 10014 Sequence ID DKLA_KLLA0A11462g Link to cluster sequenc

  5. Antibodies Against Human BLyS and APRIL Attenuate EAE Development in Marmoset Monkeys

    NARCIS (Netherlands)

    S.A. Jagessar (Anwar); N. Heijmans (Nicole); J. Bauer; E. Blezer (Erwin); J.D. Laman (Jon); T.S. Migone (Thi-Sau); M.N. Devalaraja (Matt); B.A. 't Hart (Bert)

    2012-01-01

    textabstractB lymphocyte stimulator (BLyS, also indicated as BAFF (B-cell activating factor) and CD257), and A Proliferation Inducing Ligand (APRIL, CD256) are two members of the TNF superfamily with a central role in B cell survival. Antibodies against these factors have potential therapeutic relev

  6. Antibodies Against Human BLyS and APRIL Attenuate EAE Development in Marmoset Monkeys

    NARCIS (Netherlands)

    Jagessar, S. Anwar; Heijmans, Nicole; Bauer, Jan; Blezer, Erwin L. A.; Laman, Jon D.; Migone, Thi-Sau; Devalaraja, Matt N.; 't Hart, Bert A.

    2012-01-01

    B lymphocyte stimulator (BLyS, also indicated as BAFF (B-cell activating factor) and CD257), and A Proliferation Inducing Ligand (APRIL, CD256) are two members of the TNF superfamily with a central role in B cell survival. Antibodies against these factors have potential therapeutic relevance in auto

  7. Starloc (Sandia TARget LOcation Computer): A special-purpose computer architecture for target location within an image

    Energy Technology Data Exchange (ETDEWEB)

    Napolitano, L.M. Jr.; Bryson, P.R.; Berry, K.R.; Klapp, S.R.; Leeper, J.E.; Redinbo, G.R.

    1988-01-01

    Starloc (Sandia TARget LOcation Computer) is a special-purpose computer designed for target location in an image. It is now under development and when completed will process two 256 pixel by 256 pixel input images per second, recognizing targets within them regardless of target variations such as rotation, range, brightness, and angle of view. Starloc's basic architecture consists of ten pipelined processing stages (eight for Fast Fourier Transform operations and two for pixel by pixel operations) arranged in a ring-like structure. Within each stage are a controller, image memory, address generator, and register file with parallel floating-point processors. Starloc is designed to be fault tolerant by including two hot standby stages that can be switched into the data path when other stages fail and by incorporating a comprehensive set of error checkers. Using currently available 10 MFLOP (million floating-point operations per second) floating-point processors, Starloc will run at a sustained rate of 188 MFLOPS with 94% efficiency. At this rate, it is performing 36 complex 256 pixel by 256 pixel two-dimensional Fast Fourier Transforms per second. 5 refs., 7 figs.

  8. Water Flow through Xylem: An Investigation of a Fluid Dynamics Principle Applied to Plants

    Science.gov (United States)

    Rice, Stanley A.; McArthur, John

    2004-01-01

    A study was conducted to prove that a large blood or xylem vessel could conduct 256 times more fluid than a vessel or a pipe that is four times smaller. The result of this study proved that if arteriosclerosis causes an artery to loose half its effective diameter, the blood flow would be reduced by fifteen-sixteenths.

  9. Acculturation and Aggression in Latino Adolescents: Modeling Longitudinal Trajectories from the Latino Acculturation and Health Project

    Science.gov (United States)

    Smokowski, Paul Richard; Rose, Roderick A.; Bacallao, Martica

    2009-01-01

    This study examines how multiple indicators of adolescent and parent acculturation relate to longitudinal trajectories of Latino adolescent aggression. The hierarchical linear modeling analysis is based on a final sample of 256 adolescents paired with one parent. Of the adolescents, 66% were born outside of the United States and the remaining 34%…

  10. New Image-Based Techniques for Prostate Biopsy and Treatment

    Science.gov (United States)

    2012-04-01

    Stranded Seeds Following Prostate Brachytherapy Julio R. Lobo, Mehdi Moradi, Nick Chng, Ehsan Dehghan, William J. Morris, Gabor Fichtinger, and...statistical texture matching method. IEEE Trans. Med. Imaging 25(3), 256– 272 (2006) 4. Hodge , A.C., Fenster, A., Downey, D.B., Ladak, H.M.: Prostate boundary

  11. Rebound Attacks on the Reduced Grøstl Hash Function

    DEFF Research Database (Denmark)

    Mendel, Florian; Rechberger, C.; Schlaffer, Martin;

    2010-01-01

    Grøstl is one of 14 second round candidates of the NIST SHA-3 competition. Cryptanalytic results on the wide-pipe compression function of Grøstl-256 have already been published. However, little is known about the hash function, arguably a much more interesting cryptanalytic setting. Also, Grøstl-...

  12. Measurement of Anisotropic Elastic Constitutive Properties at High Temperatures

    Science.gov (United States)

    2006-05-31

    1295 (1997) 6. Ing, R. K. and Fink, M., IEEE Trans. Ultrason. Ferroelectr. Freq. Control 45(4), 1032-1043 (1998). 7. Prada , C. and Fink, M., Wave...256. 7 Telschow, K.L., J.B. Walter, G.V. Garcia , D.C.Kunerth, “Process monitoring using Optical Ultrasonic Wave Detection. Review of Progress in

  13. A Disruption of ctpA Encoding Carboxy-Terminal Protease Attenuates Burkholderia mallei and Induces Partial Protection in CD1 Mice

    Science.gov (United States)

    2008-06-03

    depression , shortness of breath, diarrhea, and rapid weight loss with mortality [1,2]. Death may occur after a few weeks from an acute infection...microbiologist. N Engl J Med 2001;345:256–8. [6] Kaufmann AF, Meltzer MI, Schmid GP. The economic impact of a bioterrorist attack: are prevention and postattack

  14. Behavior of Materials at Cold Regions Temperatures. Part 1. Program Rationale and Test Plan

    Science.gov (United States)

    1988-07-01

    tempera- polycarbonate molding material (Titus 1967). ture of polycarbonate ( Merlon ) (Titus 1967). 001 4 45 a 30 S 25U - 20 -. 4 15, 4 "’"~ . 20 • - 0a...impact strength vs Figure B43. Urethane foam spring rate vs tern- temperature of ( Merlon ) polycarbon- perature (Titus 1967). ate (ASTM) D-256) (Titus

  15. A Laser-Diode End-Pumped Nd:YVO4 Slab Laser at 1342 nm

    Institute of Scientific and Technical Information of China (English)

    YAN Ying; ZHANG Heng-Li; LIU Yang; XING Ji-Chuan; XIN Jian-Guo

    2009-01-01

    A laser-diode end-pumped Nd:YV04 slab laser with a fiat-concave stable cavity at 1342nm is demonstrated. Under the pumping power of 92 W, a cw laser of output 17.8 W is obtained with the slope efficiency of 25.6%.

  16. European Analytical Criteria: Past, Present and Future

    NARCIS (Netherlands)

    Vanhaecke, L.; Gowik, P.; Bizec, Le B.; Ginkel, van L.A.; Bichon, E.; Blokland, M.H.; Brabander, de H.F.

    2011-01-01

    In this paper, the past, present, and (possible) future of the European analytical criteria for residues are described. The elaboration of the revision of Commission Decision 93/256/EC was a long process starting in 1996 and ending with the formation of a European Commission (EC) working group in 19

  17. Civil-Military Relations: A Selected Bibliography

    Science.gov (United States)

    2011-05-01

    Relations." In Armed Forces and Society: New Challenges and Environments, edited by Centro de Estudios e Investigaciones Militares, 241-256. Santiago, Chile...CESIM [Centro de Estudios e Investigaciones Militares], June 2009. http://cronopio.flacso.cl/fondo/pub/ openaccess/2009/libro/030889.pdf#page=242

  18. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

    NARCIS (Netherlands)

    Hobbs, Brian D; de Jong, Kim; Lamontagne, Maxime; Bossé, Yohan; Shrine, Nick; Artigas, María Soler; Wain, Louise V; Hall, Ian P; Jackson, Victoria E; Wyss, Annah B; London, Stephanie J; North, Kari E; Franceschini, Nora; Strachan, David P; Beaty, Terri H; Hokanson, John E; Crapo, James D; Castaldi, Peter J; Chase, Robert P; Bartz, Traci M; Heckbert, Susan R; Psaty, Bruce M; Gharib, Sina A; Zanen, Pieter; Lammers, Jan W; Oudkerk, Matthijs; Groen, H J; Locantore, Nicholas; Tal-Singer, Ruth; Rennard, Stephen I; Vestbo, Jørgen; Timens, Wim; Paré, Peter D; Latourelle, Jeanne C; Dupuis, Josée; O'Connor, George T; Wilk, Jemma B; Kim, Woo Jin; Lee, Mi Kyeong; Oh, Yeon-Mok; Vonk, Judith M; de Koning, Harry J; Leng, Shuguang; Belinsky, Steven A; Tesfaigzi, Yohannes; Manichaikul, Ani; Wang, Xin-Qun; Rich, Stephen S; Barr, R Graham; Sparrow, David; Litonjua, Augusto A; Bakke, Per; Gulsvik, Amund; Lahousse, Lies; Brusselle, Guy G; Stricker, Bruno H; Uitterlinden, André G; Ampleford, Elizabeth J; Bleecker, Eugene R; Woodruff, Prescott G; Meyers, Deborah A; Qiao, Dandi; Lomas, David A; Yim, Jae-Joon; Kim, Deog Kyeom; Hawrylkiewicz, Iwona; Sliwinski, Pawel; Hardin, Megan; Fingerlin, Tasha E; Schwartz, David A; Postma, Dirkje S; MacNee, William; Tobin, Martin D; Silverman, Edwin K; Boezen, H Marike; Cho, Michael H

    2017-01-01

    Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10(-6)) in 9,498 cases and 9,748 controls. In the combined meta-analysis, we identifie

  19. Genetically high plasma vitamin C, intake of fruit and vegetables, and risk of ischemic heart disease and all-cause mortality

    DEFF Research Database (Denmark)

    Kobylecki, Camilla J; Afzal, Shoaib; Davey Smith, George;

    2015-01-01

    in the sodium-dependent vitamin C transporter 1 in 97,203 white individuals of whom 10,123 subjects had ischemic heart disease, and 8477 subjects died. We measured plasma vitamin C in 3512 individuals and included dietary information on 83,256 individuals. RESULTS: The SLC23A1 rs33972313 G allele was associated...

  20. Particle size fractionation of high-amylose rice (Goami 2) flour as an oil barrier in a batter-coated fried system

    Science.gov (United States)

    The particle size effects of high-amylose rice (Goami 2) flour on quality attributes of frying batters were characterized in terms of physicochemical, rheological, and oil-resisting properties. High-amylose rice flours were fractionated into four fractions (70, 198, 256, and 415 µm) of which morpho...