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Sample records for californium 250 target

  1. Californium-252 progress, report No. 7, April 1971

    Energy Technology Data Exchange (ETDEWEB)

    1971-12-31

    This report contains discusses of the following topics on Californium-252: First sales of californium-252; encapsulation services discussed; three new participants in market evaluation program; summer training programs to use californium; Californium-252 shipping casks available; Californium-252 questions and answers, radiotherapy; neutron radiography; natural resources exploration; nuclear safeguards; process control; dosimetry; neutron radiography; neutron shielding; and nuclear safeguards.

  2. Historical review of californium-252 discovery and development

    Science.gov (United States)

    Stoddard, D. H.

    This paper discusses the discovery and history of californium 252. This isotope may be synthesized by irradiating plutonium 239, plutonium 242, americium 243, or curium 244 with neutrons in a nuclear reactor. Various experiments and inventions involving (252)Cf conducted at the Savannah River Plant are discussed. The evolution of radiotherapy using californium 252 is reviewed.

  3. Californium-252: a remarkable versatile radioisotope

    Energy Technology Data Exchange (ETDEWEB)

    Osborne-Lee, I.W.; Alexander, C.W.

    1995-10-10

    A product of the nuclear age, Californium-252 ({sup 252}Cf) has found many applications in medicine, scientific research, industry, and nuclear science education. Californium-252 is unique as a neutron source in that it provides a highly concentrated flux and extremely reliable neutron spectrum from a very small assembly. During the past 40 years, {sup 252}Cf has been applied with great success to cancer therapy, neutron radiography of objects ranging from flowers to entire aircraft, startup sources for nuclear reactors, fission activation for quality analysis of all commercial nuclear fuel, and many other beneficial uses, some of which are now ready for further growth. Californium-252 is produced in the High Flux Isotope Reactor (HFIR) and processed in the Radiochemical Engineering Development Center (REDC), both of which are located at the Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee. The REDC/HFIR facility is virtually the sole supplier of {sup 252}Cf in the western world and is the major supplier worldwide. Extensive exploitation of this product was made possible through the {sup 252}Cf Market Evaluation Program, sponsored by the United States Department of Energy (DOE) [then the Atomic Energy Commission (AEC) and later the Energy Research and Development Administration (ERDA)]. This program included training series, demonstration centers, seminars, and a liberal loan policy for fabricated sources. The Market Evaluation Program was instituted, in part, to determine if large-quantity production capability was required at the Savannah River Laboratory (SRL). Because of the nature of the product and the means by which it is produced, {sup 252}Cf can be produced only in government-owned facilities. It is evident at this time that the Oak Ridge research facility can meet present and projected near-term requirements. The production, shipment, and sales history of {sup 252}Cf from ORNL is summarized herein.

  4. Production, Distribution, and Applications of Californium-252 Neutron Sources

    Energy Technology Data Exchange (ETDEWEB)

    Balo, P.A.; Knauer, J.B.; Martin, R.C.

    1999-10-03

    The radioisotope {sup 252}Cf is routinely encapsulated into compact, portable, intense neutron sources with a 2.6-year half-life. A source the size of a person's little finger can emit up to 10{sup 11} neutrons/s. Californium-252 is used commercially as a reliable, cost-effective neutron source for prompt gamma neutron activation analysis (PGNAA) of coal, cement, and minerals, as well as for detection and identification of explosives, laud mines, and unexploded military ordnance. Other uses are neutron radiography, nuclear waste assays, reactor start-up sources, calibration standards, and cancer therapy. The inherent safety of source encapsulations is demonstrated by 30 years of experience and by U.S. Bureau of Mines tests of source survivability during explosions. The production and distribution center for the U. S Department of Energy (DOE) Californium Program is the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory (ORNL). DOE sells The radioisotope {sup 252}Cf is routinely encapsulated into compact, portable, intense neutron sources with a 2.6- year half-life. A source the size of a person's little finger can emit up to 10 neutrons/s. Californium-252 is used commercially as a reliable, cost-effective neutron source for prompt gamma neutron activation analysis (PGNAA) of coal, cement, and minerals, as well as for detection and identification of explosives, laud mines, and unexploded military ordnance. Other uses are neutron radiography, nuclear waste assays, reactor start-up sources, calibration standards, and cancer therapy. The inherent safety of source encapsulations is demonstrated by 30 years of experience and by U.S. Bureau of Mines tests of source survivability during explosions. The production and distribution center for the U. S Department of Energy (DOE) Californium Program is the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory(ORNL). DOE sells {sup 252}Cf to commercial

  5. Unusual structure, bonding and properties in a californium borate

    Energy Technology Data Exchange (ETDEWEB)

    Polinski, Matthew J.; Garner, Edward B.; Maurice, Rémi; Planas, Nora; Stritzinger, Jared T.; Parker, T. Gannon; Cross, Justin N.; Green, Thomas D.; Alekseev, Evgeny V.; Van Cleve, Shelley M.; Depmeier, Wulf; Gagliardi, Laura; Shatruk, Michael; Knappenberger, Kenneth L.; Liu, Guokui; Skanthakumar, S.; Soderholm, Lynda; Dixon, David A.; Albrecht-Schmitt, Thomas E.

    2014-03-23

    The participation of the valence orbitals of actinides in bonding has been debated for decades. Recent experimental and computational investigations demonstrated the involvement of 6p, 6d and/or 5f orbitals in bonding. However, structural and spectroscopic data, as well as theory, indicate a decrease in covalency across the actinide series, and the evidence points to highly ionic, lanthanide-like bonding for late actinides. Here we show that chemical differentiation between californium and lanthanides can be achieved by using ligands that are both highly polarizable and substantially rearrange on complexation. A ligand that suits both of these desired properties is polyborate. We demonstrate that the 5f, 6d and 7p orbitals are all involved in bonding in a Cf(III) borate, and that large crystal-field effects are present. Synthetic, structural and spectroscopic data are complemented by quantum mechanical calculations to support these observations.

  6. Extraction of Trivalent Actinides and Lanthanides from Californium Campaign Rework Solution Using TODGA-based Solvent Extraction System

    Energy Technology Data Exchange (ETDEWEB)

    Benker, Dennis [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Delmau, Laetitia Helene [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dryman, Joshua Cory [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-07-01

    This report presents the studies carried out to demonstrate the possibility of quantitatively extracting trivalent actinides and lanthanides from highly acidic solutions using a neutral ligand-based solvent extraction system. These studies stemmed from the perceived advantage of such systems over cationexchange- based solvent extraction systems that require an extensive feed adjustment to make a low-acid feed. The targeted feed solutions are highly acidic aqueous phases obtained after the dissolution of curium targets during a californium (Cf) campaign. Results obtained with actual Cf campaign solutions, but highly diluted to be manageable in a glove box, are presented, followed by results of tests run in the hot cells with Cf campaign rework solutions. It was demonstrated that a solvent extraction system based on the tetraoctyl diglycolamide molecule is capable of quantitatively extracting trivalent actinides from highly acidic solutions. This system was validated using actual feeds from a Cf campaign.

  7. Biomedical neutron research at the Californium User Facility for neutron science

    Energy Technology Data Exchange (ETDEWEB)

    Martin, R.C. [Oak Ridge National Lab., TN (United States); Byrne, T.E. [Roane State Community College, Harriman, TN (United States); Miller, L.F. [Univ. of Tennessee, Knoxville, TN (United States)

    1997-04-01

    The Californium User Facility for Neutron Science has been established at Oak Ridge National Laboratory (ORNL). The Californium User Facility (CUF) is a part of the larger Californium Facility, which fabricates and stores compact {sup 252}Cf neutron sources for worldwide distribution. The CUF can provide a cost-effective option for research with {sup 252}Cf sources. Three projects at the CUF that demonstrate the versatility of {sup 252}Cf for biological and biomedical neutron-based research are described: future establishment of a {sup 252}Cf-based neutron activation analysis system, ongoing work to produce miniature high-intensity, remotely afterloaded {sup 252}Cf sources for tumor therapy, and a recent experiment that irradiated living human lung cancer cells impregnated with experimental boron compounds to test their effectiveness for boron neutron capture therapy.

  8. Beyond Californium-A Neutron Generator Alternative for Dosimetry and Instrument Calibration in the U.S.

    Science.gov (United States)

    Piper, Roman K; Mozhayev, Andrey V; Murphy, Mark K; Thompson, Alan K

    2017-09-01

    Evaluations of neutron survey instruments, area monitors, and personal dosimeters rely on reference neutron radiations, which have evolved from the heavy reliance on (α,n) sources to a shared reliance on (α,n) and the spontaneous fission neutrons of californium-252 (Cf). Capable of producing high dose equivalent rates from an almost point source geometry, the characteristics of Cf are generally more favorable when compared to the use of (α,n) and (γ,n) sources or reactor-produced reference neutron radiations. Californium-252 is typically used in two standardized configurations: unmoderated, to yield a fission energy spectrum; or with the capsule placed within a heavy-water moderating sphere to produce a softened spectrum that is generally considered more appropriate for evaluating devices used in nuclear power plant work environments. The U.S. Department of Energy Cf Loan/Lease Program, a longtime origin of affordable Cf sources for research, testing and calibration, was terminated in 2009. Since then, high-activity sources have become increasingly cost-prohibitive for laboratories that formerly benefited from that program. Neutron generators, based on the D-T and D-D fusion reactions, have become economically competitive with Cf and are recognized internationally as important calibration and test standards. Researchers from the National Institute of Standards and Technology and the Pacific Northwest National Laboratory are jointly considering the practicality and technical challenges of implementing neutron generators as calibration standards in the U.S. This article reviews the characteristics of isotope-based neutron sources, possible isotope alternatives to Cf, and the rationale behind the increasing favor of electronically generated neutron options. The evaluation of a D-T system at PNNL has revealed characteristics that must be considered in adapting generators to the task of calibration and testing where accurate determination of a dosimetric quantity is

  9. Discovery of abundant cellulose microfibers encased in 250 Ma Permian halite: a macromolecular target in the search for life on other planets.

    Science.gov (United States)

    Griffith, Jack D; Willcox, Smaranda; Powers, Dennis W; Nelson, Roger; Baxter, Bonnie K

    2008-04-01

    In this study, we utilized transmission electron microscopy to examine the contents of fluid inclusions in halite (NaCl) and solid halite crystals collected 650 m below the surface from the Late Permian Salado Formation in southeastern New Mexico (USA). The halite has been isolated from contaminating groundwater since deposition approximately 250 Ma ago. We show that abundant cellulose microfibers are present in the halite and appear remarkably intact. The cellulose is in the form of 5 nm microfibers as well as composite ropes and mats, and was identified by resistance to 0.5 N NaOH treatment and susceptibility to cellulase enzyme treatment. These cellulose microfibers represent the oldest native biological macromolecules to have been directly isolated, examined biochemically, and visualized (without growth or replication) to date. This discovery points to cellulose as an ideal macromolecular target in the search for life on other planets in our Solar System.

  10. Apparatus for the measurement of total body nitrogen using prompt neutron activation analysis with californium-252.

    Science.gov (United States)

    Mackie, A; Hannan, W J; Smith, M A; Tothill, P

    1988-01-01

    Details of clinical apparatus designed for the measurement of total body nitrogen (as an indicator of body protein), suitable for the critically ill, intensive-care patient are presented. Californium-252 radio-isotopic neutron sources are used, enabling a nitrogen measurement by prompt neutron activation analysis to be made in 40 min with a precision of +/- 3.2% for a whole body dose equivalent of 0.145 mSv. The advantages of Californium-252 over alternative neutron sources are discussed. A comparison between two irradiation/detection geometries is made, leading to an explanation of the geometry adopted for the apparatus. The choice of construction and shielding materials to reduce the count rate at the detectors and consequently to reduce the pile-up contribution to the nitrogen background is discussed. Salient features of the gamma ray spectroscopy system to reduce spectral distortion from pulse pile-up are presented.

  11. Safety Analysis Report for Packaging (SARP) of the Oak Ridge National Laboratory TRU Californium Shipping Container

    Energy Technology Data Exchange (ETDEWEB)

    Box, W.D.; Shappert, L.B.; Seagren, R.D.; Klima, B.B.; Jurgensen, M.C.; Hammond, C.R.; Watson, C.D.

    1980-01-01

    An analytical evaluation of the Oak Ridge National Laboratory TRU Californium Shipping Container was made in order to demonstrate its compliance with the regulations governing off-site shipment of packages that contain radioactive material. The evaluation encompassed five primary categories: structural integrity, thermal resistance, radiation shielding, nuclear criticality safety, and quality assurance. The results of this evaluation demonstrate that the container complies with the applicable regulations.

  12. Act250 Permits

    Data.gov (United States)

    Vermont Center for Geographic Information — The dataset includes the geographic location for Act 250 permits issued since the inception of the law in 1970. Base permit numbers only are included; permit...

  13. ACT250 Districts

    Data.gov (United States)

    Vermont Center for Geographic Information — The ACT 250 Districts layer is part of a larger dataset that contains administrative boundaries for Vermont's Agency of Natural Resources. The dataset includes...

  14. Application of TSH bioindicator for studying the biological efficiency of neutrons from californium-252 source

    Energy Technology Data Exchange (ETDEWEB)

    Cebulska-Wasilewska, A.; Rekas, K. [Institute of Nuclear Physics, Cracow (Poland); Kim, J.K. [Korea Atomic Energy Research Inst., Taejon (Korea, Republic of)

    1997-12-31

    The effectiveness of neutrons from a Californium-252 source in the induction of various abnormalities in the Tradescantia clone 4430 stamen hair cells (TSH-assay) was studied. The special attention was paid to check whether any enhancement in effects caused by process of boron neutron capture is visible in the cells enriched with boron ions. Two chemicals (borax and BSH) were applied to introduce boron-10 ions into cells. Inflorescence, normal or pretreated with chemicals containing boron, were irradiated in the air with neutrons from a Cf-252 source at KAERI, Taejon, Korea. To estimate the relative biological effectiveness (RBE) in the induction of gene mutations of the neutron beam under the study, Tradescantia inflorescences, without any chemical pretreatment, were irradiated with various doses of X-rays. The ranges of radiation doses used were 0-0.1 Gy in neutrons and 0-0.5 Gy in X-rays. After the time needed to complete the postirradiation repair Tradescantia cuttings were transferred to Cracow, where screening of gene and lethal; mutations, cell cycle alterations in somatic cells have been done, and dose response relationships were figured. The maximal RBE values were estimated in the range of 4.6-6.8. Alterations of RBE value were observed; from 6.8 to 7.8 in the case of plants pretreated with 240 ppm of B-10 from borax, and 4.6 to 6.1 in the case of 400 ppm of B-10 from BSH. Results showed a slight, although statistically insignificant increase in biological efficacy of radiation from the Cf-252 source in samples pretreated with boron containing chemicals. (author)

  15. Study of the shielding for spontaneous fission sources of Californium-252; Estudio de blindaje para fuentes de fision espontanea de Californio-252

    Energy Technology Data Exchange (ETDEWEB)

    Davila R, I

    1991-06-15

    A shielding study is made to attenuate, until maximum permissible levels, the neutrons radiation and photons emitted by spontaneous fission coming from a source of Californium-252. The compound package by a database (Library DLC-23) and the ANISNW code is used, in it version for personal computer. (Author)

  16. Simulation and design of an electron beam ion source charge breeder for the californium rare isotope breeder upgrade

    Directory of Open Access Journals (Sweden)

    Clayton Dickerson

    2013-02-01

    Full Text Available An electron beam ion source (EBIS will be constructed and used to charge breed ions from the californium rare isotope breeder upgrade (CARIBU for postacceleration into the Argonne tandem linear accelerator system (ATLAS. Simulations of the EBIS charge breeder performance and the related ion transport systems are reported. Propagation of the electron beam through the EBIS was verified, and the anticipated incident power density within the electron collector was identified. The full normalized acceptance of the charge breeder with a 2 A electron beam, 0.024π  mm mrad for nominal operating parameters, was determined by simulating ion injection into the EBIS. The optics of the ion transport lines were carefully optimized to achieve well-matched ion injection, to minimize emittance growth of the injected and extracted ion beams, and to enable adequate testing of the charge bred ions prior to installation in ATLAS.

  17. Californium-252 Brachytherapy Combined With External-Beam Radiotherapy for Cervical Cancer: Long-Term Treatment Results

    Energy Technology Data Exchange (ETDEWEB)

    Lei Xin; Qian Chengyuan; Qing Yi; Zhao Kewei; Yang Zhengzhou; Dai Nan; Zhong Zhaoyang; Tang Cheng; Li Zheng; Gu Xianqing; Zhou Qian; Feng Yan; Xiong Yanli; Shan Jinlu [Cancer Center, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing (China); Wang Dong, E-mail: dongwang64@hotmail.com [Cancer Center, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing (China)

    2011-12-01

    Purpose: To observe, by retrospective analysis, the curative effects and complications due to californium-252 ({sup 252}Cf) neutron intracavitary brachytherapy (ICBT) combined with external-beam radiotherapy (EBRT) in the treatment of cervical cancer. Methods and Materials: From February 1999 to December 2007, 696 patients with cervical cancer (Stages IB to IIIB) were treated with {sup 252}Cf-ICBT in combination of EBRT. Of all, 31 patients were at Stage IB, 104 at IIA, 363 at IIB, 64 at IIIA, and 134 at IIIB. Californium-252 ICBT was delivered at 7-12 Gy per insertion per week, with a total dose of 29-45 Gy to reference point A in three to five insertions. The whole pelvic cavity was treated with 8-MV X-ray external irradiation at 2 Gy per fraction, four times per week. After 16-38 Gy of external irradiation, the center of the whole pelvic field was blocked with a 4-cm-wide lead shield, with a total external irradiation dose of 44-56 Gy. The total treatment course was 5 to 6 weeks. Results: Overall survival rate at 3 and 5 years for all patients was 76.0% and 64.9%, respectively. Disease-free 3- and 5-year survival rates of patients were 71.2% and 58.4%, respectively. Late complications included vaginal contracture and adhesion, radiation proctitis, radiation cystitis, and inflammatory bowel, which accounted for 5.8%, 7.1%, 6.2%, and 4.9%, respectively. Univariate analysis results showed significant correlation of stage, age, histopathologic grade, and lymph node status with overall survival. Cox multiple regression analysis showed that the independent variables were stage, histopathologic grade, tumor size, and lymphatic metastasis in all patients. Conclusion: Results of this series suggest that the combined use of {sup 252}Cf-ICBT with EBRT is an effective method for treatment of cervical cancer.

  18. Long-term effects of an intracavitary treatment with californium-252 on normal tissue. [Swine, /sup 226/Ra

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, M.F.; Beamer, J.L.; Mahony, T.D.; Cross, F.T.; Lund, J.E.; Endres, G.W.R.

    1976-01-01

    About one hundred fifty swine were exposed to either radium-226 or californium-252 sources in the uterine cervix to determine an RBE for both acute and long-term effects. That value for early changes in the tissues at risk in the treatment of cervical cancer was between 6.2 and 6.8. The incidence of complications increased with time after exposure, especially among animals treated with /sup 252/Cf. Analysis of rectal injury showed that ulceration occurred frequently within a year postexposure at doses between 1600 and 2400 rad calculated at 2 cm lateral to the source midline. Fat necrosis and smooth muscle atrophy, resulting in a local rectal stricture, were delayed changes observed in some animals. The lower ureter was the site for a greater frequency of complications than the GI tract. Ureteral stricture often occurred at doses of 1200 rad from /sup 252/Cf and 7000 rad from /sup 226/Ra. Observation of delayed effects in the uterine-cervix in animals held up to 4 years postexposure indicate that the RBE for /sup 252/Cf may be increased to a value as high as 18, while repair may have even decreased it to about 5.6 in the rectum. Fifty swine are still being observed for long-term effects after doses above 800 rad from /sup 252/Cf and 5000 rad from /sup 226/Ra.

  19. Ab initio full-potential study of mechanical properties and magnetic phase stability of californium monopnictides (CfN and CfP)

    Energy Technology Data Exchange (ETDEWEB)

    Amari, S., E-mail: siham_amari@yahoo.fr [Faculté des Sciences de la Nature et de la Vie, Université Hassiba Benbouali, Chlef, 02000 (Algeria); Bouhafs, B. [Laboratoire de Modélisation et Simulation en Sciences des Matériaux, Université Djillali Liabès de Sidi Bel-Abbés, Sidi Bel-Abbés, 22000 (Algeria)

    2016-09-15

    Based on the first-principles methods, the structural, elastic, electronic, properties and magnetic ordering of californium monopnictides CfX (X = P) have been studied using the full-potential augmented plane wave plus local orbitals (FP-L/APW + lo) method within the framework of density functional theory (DFT). The electronic exchange correlation energy is described by generalized gradient approximation GGA and GGA+U (U is the Hubbard correction). The GGA+U method is applied to the rare-earth 5f states. We have calculated the lattice parameters, bulk modulii and the first pressure derivatives of the bulk modulii. The elastic properties of the studied compounds are only investigated in the most stable calculated phase. In order to gain further information, we have calculated Young’s modulus, shear modulus, anisotropy factor and Kleinman parameter by the aid of the calculated elastic constants. The results mainly show that californium monopnictides CfX (X = P) have an antiferromagnetic spin ordering. Density of states (DOS) and charge densities for both compounds are also computed in the NaCl (B1) structure.

  20. Low-Dose-Rate Californium-252 Neutron Intracavitary Afterloading Radiotherapy Combined With Conformal Radiotherapy for Treatment of Cervical Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Min [Department of Oncology, Armed Police Hospital of Hangzhou, Hangzhou, Zhejiang Province (China); Xu Hongde [Cancer Center, Armed Police Hospital of Hangzhou, Hangzhou, Zhejiang Province (China); Pan Songdan; Lin Shan; Yue Jianhua [Department of Oncology, Armed Police Hospital of Hangzhou, Hangzhou, Zhejiang Province (China); Liu Jianren, E-mail: liujianren0571@hotmail.com [Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province (China)

    2012-07-01

    Purpose: To study the efficacy of low-dose-rate californium-252 ({sup 252}Cf) neutron intracavitary afterloading radiotherapy (RT) combined with external pelvic RT for treatment of cervical cancer. Methods and Materials: The records of 96 patients treated for cervical cancer from 2006 to 2010 were retrospectively reviewed. For patients with tumors {<=}4 cm in diameter, external beam radiation was performed (1.8 Gy/day, five times/week) until the dose reached 20 Gy, and then {sup 252}Cf neutron intracavitary afterloading RT (once/week) was begun, and the frequency of external beam radiation was changed to four times/week. For patients with tumors >4 cm, {sup 252}Cf RT was performed one to two times before whole-pelvis external beam radiation. The tumor-eliminating dose was determined by using the depth limit of 5 mm below the mucosa as the reference point. In all patients, the total dose of the external beam radiation ranged from 46.8 to 50 Gy. For {sup 252}Cf RT, the dose delivered to point A was 6 Gy/fraction, once per week, for a total of seven times, and the total dose was 42 Gy. Results: The mean {+-} SD patient age was 54.7 {+-} 13.7 years. Six patients had disease assessed at stage IB, 13 patients had stage IIA, 49 patients had stage IIB, 3 patients had stage IIIA, 24 patients had stage IIIB, and 1 patient had stage IVA. All patients obtained complete tumor regression (CR). The mean {+-} SD time to CR was 23.5 {+-} 3.4 days. Vaginal bleeding was fully controlled in 80 patients within 1 to 8 days. The mean {+-} SD follow-up period was 27.6 {+-} 12.7 months (range, 6-48 months). Five patients died due to recurrence or metastasis. The 3-year survival and disease-free recurrence rates were 89.6% and 87.5 %, respectively. Nine patients experienced mild radiation proctitis, and 4 patients developed radiocystitis. Conclusions: Low-dose-rate {sup 252}Cf neutron RT combined with external pelvic RT is effective for treating cervical cancer, with a low incidence of

  1. 48 CFR 1846.673 - Distribution of DD Forms 250 and 250c.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Distribution of DD Forms... Reports 1846.673 Distribution of DD Forms 250 and 250c. (a) DD Forms 250 and 250c shall be distributed in accordance with installation procedures. (b) The contractor is responsible for distributing DD Forms 250 and...

  2. [Prokaryotic expression, purification and antigenicity identification of human renal cell carcinoma-associated antigen G250].

    Science.gov (United States)

    Xiao, Yi; Gao, Jiangping; Gao, Kun; Yan, Jinqi; Zhang, Liang; Wang, Yu; Xu, Yuanji; Wang, Wei; Wang, Xiaoxiong; Yu, Jiyun

    2013-03-01

    To amplify human renal cell carcinoma (RCC)-associated antigen G250 gene and construct a recombinant plasmid pET-42a-hG250, express and purify human G250 protein and identify its antigenicity. The gene of human G250 was amplified from pGEM-T-G250 by PCR. After sequencing, the PCR product (112-1242 bp) was cloned into pET-42a prokaryotic expression vector to construct the recombinant plasmid pET-42a-hG250. The plasmid was transformed into BL21 (DE3) and human G250 protein was expressed under the induction of IPTG. The fusion protein was purified and identified by SDS-PAGE, Western blotting and ELISA sequentially. The human G250 prokaryotic expression vector pET-42a-hG250 was successfully constructed as confirmed by enzyme digestion and DNA sequencing. After transformation into BL21 (DE3), the target protein was successfully induced to express and purified as expected. Western blotting and ELISA demonstrated that the purified human G250 protein had a desirable immunogenicity. The recombinant prokaryotic expression vector pET-42a-hG250 has been constructed successfully. The purified human G250 protein has a good antigenicity.

  3. 21 CFR 74.250 - Orange B.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Orange B. 74.250 Section 74.250 Food and Drugs... ADDITIVES SUBJECT TO CERTIFICATION Foods § 74.250 Orange B. (a) Identity. (1) The color additive Orange B is.... (2) The diluents in color additive mixtures for food use containing Orange B are limited to those...

  4. 30 CFR 250.1614 - Mud program.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Mud program. 250.1614 Section 250.1614 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1614 Mud program. (a) The quantities...

  5. 30 CFR 250.604 - Hydrogen sulfide.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Hydrogen sulfide. 250.604 Section 250.604... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Workover Operations § 250.604 Hydrogen sulfide. When a well-workover operation is conducted in zones known to contain hydrogen sulfide (H2S) or in...

  6. 30 CFR 250.504 - Hydrogen sulfide.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Hydrogen sulfide. 250.504 Section 250.504... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Completion Operations § 250.504 Hydrogen sulfide. When a well-completion operation is conducted in zones known to contain hydrogen sulfide (H2S) or in...

  7. 30 CFR 250.808 - Hydrogen sulfide.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Hydrogen sulfide. 250.808 Section 250.808... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Production Safety Systems § 250.808 Hydrogen sulfide. Production operations in zones known to contain hydrogen sulfide (H2S) or in zones where the presence of H2S...

  8. 30 CFR 250.1633 - Production measurement.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Production measurement. 250.1633 Section 250... SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1633 Production measurement. (a) General. Measurement equipment and security procedures shall be designed, installed, used, maintained, and...

  9. 7 CFR 250.19 - Reviews.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Reviews. 250.19 Section 250.19 Agriculture Regulations... TERRITORIES AND POSSESSIONS AND AREAS UNDER ITS JURISDICTION General Operating Provisions § 250.19 Reviews. (a) General. Each distributing agency shall establish a review system in order to assess the effectiveness of...

  10. 30 CFR 250.1632 - Production rates.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Production rates. 250.1632 Section 250.1632 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1632 Production rates. Each sulphur...

  11. 45 CFR 2541.250 - Program income.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Program income. 2541.250 Section 2541.250 Public... Post-Award Requirements § 2541.250 Program income. (a) General. Grantees are encouraged to earn income to defray program costs. Program income includes income from fees for services performed, from the...

  12. 40 CFR 723.250 - Polymers.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Polymers. 723.250 Section 723.250... PREMANUFACTURE NOTIFICATION EXEMPTIONS Specific Exemptions § 723.250 Polymers. (a) Purpose and scope. (1) This...) of the Toxic Substances Control Act (15 U.S.C. 2604(a)(1)(A)) for the manufacture of certain polymers...

  13. 30 CFR 250.1008 - Reports.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Reports. 250.1008 Section 250.1008 Mineral... OPERATIONS IN THE OUTER CONTINENTAL SHELF Pipelines and Pipeline Rights-of-Way § 250.1008 Reports. (a) The... lessee or right-of-way holder shall submit a report to the Regional Supervisor within 90 days after...

  14. 7 CFR 250.17 - Reports.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Reports. 250.17 Section 250.17 Agriculture Regulations... TERRITORIES AND POSSESSIONS AND AREAS UNDER ITS JURISDICTION General Operating Provisions § 250.17 Reports. (a) Inventory reports and receipt of donated foods. Distributing agencies shall complete and submit to the FNSRO...

  15. 21 CFR 73.250 - Fruit juice.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Fruit juice. 73.250 Section 73.250 Food and Drugs... ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.250 Fruit juice. (a) Identity. (1) The color additive fruit juice is prepared either by expressing the juice from mature varieties of fresh, edible fruits, or by...

  16. 30 CFR 250.1605 - Drilling requirements.

    Science.gov (United States)

    2010-07-01

    ... SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1605 Drilling requirements. (a) Lessees of OCS sulphur leases shall conduct drilling operations in accordance with §§ 250.1605 through 250... conditions for the proposed season and location of operations. (2) Prior to commencing operation, drilling...

  17. 21 CFR 820.250 - Statistical techniques.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Statistical techniques. 820.250 Section 820.250...) MEDICAL DEVICES QUALITY SYSTEM REGULATION Statistical Techniques § 820.250 Statistical techniques. (a... statistical techniques required for establishing, controlling, and verifying the acceptability of process...

  18. 7 CFR 65.250 - Slaughter.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Slaughter. 65.250 Section 65.250 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards..., PEANUTS, AND GINSENG General Provisions Definitions § 65.250 Slaughter. Slaughter means the point in which...

  19. 7 CFR 250.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Administration. 250.2 Section 250.2 Agriculture... TERRITORIES AND POSSESSIONS AND AREAS UNDER ITS JURISDICTION General § 250.2 Administration. (a) Delegation to FNS. Within the Department, FNS shall act on behalf of the Department in the administration of the...

  20. 21 CFR 175.250 - Paraffin (synthetic).

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Paraffin (synthetic). 175.250 Section 175.250 Food... for Use as Components of Coatings § 175.250 Paraffin (synthetic). Synthetic paraffin may be safely... process from carbon monoxide and hydrogen, which are catalytically converted to a mixture of paraffin...

  1. 29 CFR 786.250 - Enforcement policy.

    Science.gov (United States)

    2010-07-01

    ... POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS MISCELLANEOUS EXEMPTIONS Newspaper Publishing § 786.250 Enforcement policy. The exemption provided by paragraph 13(a)(8) of the Fair Labor... 29 Labor 3 2010-07-01 2010-07-01 false Enforcement policy. 786.250 Section 786.250 Labor...

  2. 32 CFR 250.6 - Responsibilities.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 250.6 Section 250.6 National... WITHHOLDING OF UNCLASSIFIED TECHNICAL DATA FROM PUBLIC DISCLOSURE § 250.6 Responsibilities. (a) The Under Secretary of Defense for Research and Engineering (USDR&E) shall have overall responsibility for the...

  3. 48 CFR 1846.672 - Preparing DD Forms 250 and 250c.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Preparing DD Forms 250 and 250c. 1846.672 Section 1846.672 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... DD Forms 250 and 250c. ...

  4. 36 CFR 2.50 - Special events.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Special events. 2.50 Section... PROTECTION, PUBLIC USE AND RECREATION § 2.50 Special events. (a) Sports events, pageants, regattas, public spectator attractions, entertainments, ceremonies, and similar events are allowed: Provided, however, There...

  5. 7 CFR 250.15 - Financial management.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Financial management. 250.15 Section 250.15 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... Financial management. (a) Distribution charges. (1) Recipient agencies may be required to pay part or all of...

  6. 17 CFR 250.1 - Registration.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Registration. 250.1 Section... AND REGULATIONS, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 Registration and General Exemptions § 250.1 Registration. (a) Notification of registration. Notifications of registration pursuant to section...

  7. 40 CFR 170.250 - Decontamination.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Decontamination. 170.250 Section 170... PROTECTION STANDARD Standard for Pesticide Handlers § 170.250 Decontamination. (a) Requirement. During any..., decontamination supplies for washing off pesticides and pesticide residues. (b) General conditions. (1) The...

  8. 30 CFR 250.125 - Service fees.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Service fees. 250.125 Section 250.125 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR... or ancillary system that is protected by one or more of the safety devices required by API RP 14C...

  9. Generation of chimeric bispecific G250/anti-CD3 monoclonal antibody, a tool to combat renal cell carcinoma.

    OpenAIRE

    Luiten, R. M.; Coney, L R; Fleuren, G J; Warnaar, S. O.; Litvinov, S. V.

    1996-01-01

    The monoclonal antibody (MAb) G250 binds to a tumour-associated antigen, expressed in renal cell carcinoma (RCC), which has been demonstrated to be a suitable target for antibody-mediated immunotherapy. A bispecific antibody having both G250 and anti-CD3 specificity can cross-link G250 antigen-expressing RCC target cells with T cells and can mediate lysis of such targets. Therapy studies with murine antibodies are limited by immune responses to the antibodies injected (HAMA response), which c...

  10. Californium-252 neutron intracavity brachytherapy alone for T1N0 low-lying rectal adenocarcinoma: A definitive anal sphincter-preserving radiotherapy

    Science.gov (United States)

    Xiong, Yanli; Shan, Jinlu; Liu, Jia; Zhao, Kewei; Chen, Shu; Xu, Wenjing; Zhou, Qian; Yang, Mei; Lei, Xin

    2017-01-01

    This study evaluated the 4-year results of 32 patients with T1N0 low-lying rectal adenocarcinoma treated solely with californium-252 (Cf-252) neutron intracavity brachytherapy (ICBT). Patients were solicited into the study from January 2008 to June 2011. All the patients had refused surgery or surgery was contraindicated. The patients were treated with Cf-252 neutron ICBT using a novel 3.5-cm diameter off-axis 4-channel intrarectal applicator designed by the authors. The dose reference point was defined on the mucosa surface, with a total dose of 55–62 Gy-eq/4 f (13–16 Gy-eq/f/wk). All the patients completed the radiotherapy in accordance with our protocol. The rectal lesions regressed completely, and the acute rectal toxicity was mild (≤G2). The 4-year local control, overall survival, disease-free survival, and late complication (≥G2) rates were 96.9%, 90.6%, 87.5% and 15.6%, respectively. No severe late complication (≥G3) occurred. The mean follow-up was 56.1 ± 16.0 months. At the end of last follow-up, 29 patients remained alive. The mean survival time was 82.1 ± 2.7 months. Cf-252 neutron ICBT administered as the sole treatment (without surgery) for patients with T1N0 low-lying rectal adenocarcinoma is effective with acceptable late complications. Our study and method offers a definitive anal sphincter-preserving radiotherapy for T1N0 low-lying rectal adenocarcinoma patients. PMID:28094790

  11. 7 CFR 1710.250 - General.

    Science.gov (United States)

    2010-01-01

    .... (i) A borrower's CWP or special engineering studies must be supported by a Borrower's Environmental Report, and when necessary by an Environmental Analysis or Environmental Impact Statement, as set forth... Plans and Related Studies § 1710.250 General. (a) An ongoing, integrated planning system is needed by...

  12. 20 CFR 632.250 - General.

    Science.gov (United States)

    2010-04-01

    ...' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR INDIAN AND NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.250 General. This subpart... Youth Employment and Training Program for Indians and other Native Americans authorized by title II...

  13. 30 CFR 250.1201 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR... applicable chapter of the API MPMS, which is incorporated by reference in 30 CFR 250.198. Terms used in... production from a royalty or allocation measurement point. API MPMS—the American Petroleum Institute's Manual...

  14. 30 CFR 250.1203 - Gas measurement.

    Science.gov (United States)

    2010-07-01

    ... Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR... verifiable measurement. You must follow the recommendations in API MPMS as incorporated by reference in 30... recorder is used, you must follow the recommendations in API MPMS as referenced in 30 CFR 250.198. (5) Take...

  15. 30 CFR 250.800 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR... platforms (TLPs); spars, etc.), you must do all of the following: (1) Comply with API RP 14J (incorporated... API RP 2RD (incorporated by reference as specified in 30 CFR 250.198); (3) Design all stationkeeping...

  16. 5 CFR 250.301 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... supervisors; typically those who are responsible for employees' performance appraisals and approval of their... not have supervisory responsibilities or conduct performance appraisals. Work unit means an immediate... AGENCIES Employee Surveys § 250.301 Definitions. In this part— Agency means an executive agency as defined...

  17. Johann Wilhelm Krause 250 / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    2007-01-01

    Eesti klassitsistliku arhitektuuri suurkuju ning Tartu Ülikooli arhitekti Johann Wilhelm Krause 250. sünniaastapäeva tähistati näitustega Tallinnas ja Tartus. Tartu Ülikooli raamatukogu kunstikogusse kuulub ligi 700 J. W. Krause loodud joonistust

  18. 30 CFR 250.1613 - Diverter systems.

    Science.gov (United States)

    2010-07-01

    ... OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1613 Diverter systems. (a) When drilling a conductor or cap rock hole, all drilling units shall be equipped with a diverter system consisting of a..., installed, and maintained so as to divert gases, water, mud, and other materials away from the facilities...

  19. 32 CFR 250.3 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... permanent residence and is located in the United States. (2) Such data are needed to bid or perform on a... WITHHOLDING OF UNCLASSIFIED TECHNICAL DATA FROM PUBLIC DISCLOSURE § 250.3 Definitions. (a) Qualified U.S..., certifies, as a condition of obtaining export-controlled technical data subject to this Directive from the...

  20. 38 CFR 17.250 - Scope of the grant program.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Scope of the grant program. 17.250 Section 17.250 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Grants for Exchange of Information § 17.250 Scope of the grant program. The provisions of § 17.250...

  1. IceMap250—Automatic 250 m Sea Ice Extent Mapping Using MODIS Data

    Directory of Open Access Journals (Sweden)

    Charles Gignac

    2017-01-01

    Full Text Available The sea ice cover in the North evolves at a rapid rate. To adequately monitor this evolution, tools with high temporal and spatial resolution are needed. This paper presents IceMap250, an automatic sea ice extent mapping algorithm using MODIS reflective/emissive bands. Hybrid cloud-masking using both the MOD35 mask and a visibility mask, combined with downscaling of Bands 3–7 to 250 m, are utilized to delineate sea ice extent using a decision tree approach. IceMap250 was tested on scenes from the freeze-up, stable cover, and melt seasons in the Hudson Bay complex, in Northeastern Canada. IceMap250 first product is a daily composite sea ice presence map at 250 m. Validation based on comparisons with photo-interpreted ground-truth show the ability of the algorithm to achieve high classification accuracy, with kappa values systematically over 90%. IceMap250 second product is a weekly clear sky map that provides a synthesis of 7 days of daily composite maps. This map, produced using a majority filter, makes the sea ice presence map even more accurate by filtering out the effects of isolated classification errors. The synthesis maps show spatial consistency through time when compared to passive microwave and national ice services maps.

  2. 7 CFR 958.250 - Assessment Credit Report.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Assessment Credit Report. 958.250 Section 958.250... DESIGNATED COUNTIES IN IDAHO, AND MALHEUR COUNTY, OREGON Rules and Regulations § 958.250 Assessment Credit Report. Each handler may receive a credit for assessments on onions that have been levied in accordance...

  3. 30 CFR 250.1200 - Question index table.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Question index table. 250.1200 Section 250.1200... Security § 250.1200 Question index table. The table in this section lists questions concerning Oil and Gas Production Measurement, Surface Commingling, and Security. Frequently asked questions CFR citation 1. What...

  4. 46 CFR 28.250 - High water alarms.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false High water alarms. 28.250 Section 28.250 Shipping COAST... Individuals On Board, or for Fish Tender Vessels Engaged in the Aleutian Trade § 28.250 High water alarms. On... operating station to indicate high water level in each of the following normally unmanned spaces: (a) A...

  5. 5 CFR 250.303 - Availability of results.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Availability of results. 250.303 Section 250.303 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT IN AGENCIES Employee Surveys § 250.303 Availability of results. (a) Each agency will make the results of its annual survey available to th...

  6. 30 CFR 250.1202 - Liquid hydrocarbon measurement.

    Science.gov (United States)

    2010-07-01

    ... Section 250.1202 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL... the API MPMS as incorporated by reference in 30 CFR 250.198, when obtaining net standard volume and... with the API MPMS as incorporated by reference in 30 CFR 250.198); (ii) The sample container is vapor...

  7. 7 CFR 58.250 - Dry whole milk.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Dry whole milk. 58.250 Section 58.250 Agriculture... Products Bearing Usda Official Identification § 58.250 Dry whole milk. Dry whole milk in commercial bulk... Grades of Dry Whole Milk. Quality requirements for dry whole milk in consumer packages shall be for U.S...

  8. 30 CFR 250.302 - Definitions concerning air quality.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Definitions concerning air quality. 250.302... Definitions concerning air quality. For purposes of §§ 250.303 and 250.304 of this part: Air pollutant means..., pursuant to section 109 of the Clean Air Act, national primary or secondary ambient air quality standards...

  9. 30 CFR 250.1606 - Control of wells.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Control of wells. 250.1606 Section 250.1606... OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1606 Control of wells. The lessee shall take necessary precautions to keep its wells under control at all times. Operations shall be conducted...

  10. 30 CFR 250.1612 - Well-control drills.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Well-control drills. 250.1612 Section 250.1612 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1612 Well-control drills. Well-control...

  11. 250 Years of the State Survey

    Directory of Open Access Journals (Sweden)

    Ivana Wechselberger

    2014-06-01

    Full Text Available The first topographic survey of the Habsburg Monarchy was decreed by Maria Theresa 250 years ago, on May 13, 1764. A conference was held on the occasion of the anniversary by the Austrian State Geodetic Administration (BEV – Bundesamt für Eich- und Vermessungswesen and the Institute for Military Geosciences (IMG – Institut für Militärisches Geowesen in Vienna on May 13 and 14, 2014. The conference was sort of a time travel through Austrian state surveys. Historical development and methods of the first three state surveys (18th and 19th century were presented on the first conference day. Lectures were held by representatives of Austrian scientific institutions and new countries of the Monarchy. The second conference day was dedicated to the 4th state survey (20th century and its impact on civilian and military application and economy.

  12. Characteristics of spontaneous fission of 250No

    Science.gov (United States)

    Svirikhin, A. I.; Andreev, A. V.; Yeremin, A. V.; Izosimov, I. N.; Isaev, A. V.; Kuznetsov, A. N.; Kuznetsova, A. A.; Malyshev, O. N.; Popeko, A. G.; Popov, Y. A.; Sokol, E. A.; Chelnokov, M. L.; Chepigin, V. I.; Schneidman, T. M.; Gall, B.; Dorvaux, O.; Brione, P.; Hauschild, K.; Lopez-Martenz, A.; Rezynkina, K.; Mullins, S.; Jones, P.; Mosat, P.

    2017-07-01

    This study describes an experiment on investigating the properties of spontaneous fission of shortlived neutron-deficient nuclei synthesized in the reaction of complete fusion 48Ca + 204Pb = 252No*. The experiment is performed using the SHELS separator and the beam of multicharged ions at U-400 accelerator (LNR, JINR). Two activities undergoing spontaneous fission, which can be related to the ground and isomeric states of 250No nucleus, are registered. The half-lives, total kinetic energies of fission fragments, and neutron multiplicities are measured for the short-lived nuclei. The average number of neutrons per fission for the activity with t 1/2 = 5.1 ± 0.3 μs is = 4.38 ± 0.13 μs, and for nuclei with the half-life t 1/2 = 36 ± 3 μs it is xxxxx.

  13. A study of N250 event-related brain potential during face and non-face detection tasks.

    Science.gov (United States)

    Nasr, Shahin; Esteky, Hossein

    2009-05-08

    Face perception relies on activation of a complex set of different neural modules. In this study, we assessed the stimulus selectivity of the occipitotemporal N250 ERP component and the possible link between its neural substrates and modules underlying preceding (N170/VPP) and following (P400) category selective ERPs. We recorded N250 during face and leaf detection tasks while we varied stimulus visibility from trial to trial by using a backward masking paradigm. Our results revealed that N250, but not the other tested potentials, was exclusively sensitive to the visibility of faces even when the non-face stimuli served as the task target. We also found a correlation between evoked N170 and N250, in response to face stimuli and to a lesser extent in response to other non-face objects, irrespective of the subjects' task. Besides N250, P400 also showed a strong correlation with N170, but here, the amount of correlation was not affected by stimulus category. Interestingly, despite N250 and N400 correlation with N170, we did not find any correlation between N250 and P400, suggesting that modules underlying these ERP components belong to two different face-processing pathways. We suggest that N250 is initiated by N170 and indexes processes exclusively responsible for encoding faces.

  14. Californium-252 Program Equipment Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Chattin, Fred Rhea [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wilson, Kenton [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ezold, Julie G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-12-01

    To successfully continue the 252Cf production and meet the needs of the customers, a comprehensive evaluation of the Building 7920 processing equipment was requested to identify equipment critical to the operational continuity of the program.

  15. 21 CFR 137.250 - White corn meal.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false White corn meal. 137.250 Section 137.250 Food and... Related Products § 137.250 White corn meal. (a) White corn meal is the food prepared by so grinding cleaned white corn that when tested by the method prescribed in paragraph (b)(2) of this section not less...

  16. 30 CFR 250.1304 - How will MMS require unitization?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How will MMS require unitization? 250.1304... AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Unitization § 250.1304 How will MMS... Regional Supervisor initiates compulsory unitization, MMS will serve all lessees of the proposed unit area...

  17. 30 CFR 250.118 - Will MMS approve gas injection?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Will MMS approve gas injection? 250.118 Section... AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General Performance Standards § 250.118 Will MMS... for injection, you must: (1) Show that the injection will not result in undue interference with...

  18. 41 CFR 60-250.24 - Drugs and alcohol.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Drugs and alcohol. 60-250... VETERANS Discrimination Prohibited § 60-250.24 Drugs and alcohol. (a) Specific activities permitted. The contractor: (1) May prohibit the illegal use of drugs and the use of alcohol at the workplace by all...

  19. 30 CFR 250.292 - What must the DWOP contain?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must the DWOP contain? 250.292 Section 250.292 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND... schematics and Safety Analysis Function Evaluation (SAFE) charts (API RP 14C, subsection 4.3c, incorporated...

  20. 30 CFR 250.1002 - Design requirements for DOI pipelines.

    Science.gov (United States)

    2010-07-01

    ... Section 250.1002 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL... American Petroleum Institute (API) Spec 6A, API Spec 6D, or the equivalent. A valve may not be used under..., API Spec 6A, or the equivalent (incorporated by reference as specified in 30 CFR 250.198). Each flange...

  1. 30 CFR 250.610 - Diesel engine air intakes.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Diesel engine air intakes. 250.610 Section 250... engine air intakes. No later than May 31, 1989, diesel engine air intakes shall be equipped with a device to shut down the diesel engine in the event of runaway. Diesel engines which are continuously...

  2. 30 CFR 250.510 - Diesel engine air intakes.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Diesel engine air intakes. 250.510 Section 250... engine air intakes. Diesel engine air intakes must be equipped with a device to shut down the diesel engine in the event of runaway. Diesel engines that are continuously attended must be equipped with...

  3. 30 CFR 250.463 - Who establishes field drilling rules?

    Science.gov (United States)

    2010-07-01

    ... GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Other Drilling Requirements § 250.463 Who establishes field drilling rules? (a) The District Manager may... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Who establishes field drilling rules? 250.463...

  4. 17 CFR 250.3 - Exemption of certain banks.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exemption of certain banks... Exemptions § 250.3 Exemption of certain banks. (a) General exemption. Subject to the provisions of § 250.6 and to the requirements contained in paragraph (c) of this section, any bank shall be exempt from any...

  5. 40 CFR 795.250 - Developmental neurotoxicity screen.

    Science.gov (United States)

    2010-07-01

    .... “The effects of inter-trial interval on avoidance learning in the rat.” Journal of Comparative... 40 Protection of Environment 31 2010-07-01 2010-07-01 true Developmental neurotoxicity screen. 795.250 Section 795.250 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC...

  6. Manganese determination om minerals by activation analysis, using the californium-252 as a neutron source; Determinacao de manganes em minerios, por analise por ativacao, usando californio-252 como fonte de neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Cardoso, Antonio

    1976-07-01

    Neutron Activation Analysis, using a Californium-252 neutron source, has been applied for the determination of manganese in ores such as pyrolusite, rodonite (manganese silicate)' and blending used in dry-batteries The favorable nuclear properties of manganese, such as high thermal neutron cross-section for the reaction {sup 55}Mn (n.gamma){sup 56} Mn, high concentration of manganese in the matrix and short half - life of {sup 56}Mn, are an ideal combination for non-destructive analysis of manganese in ores. Samples and standards of manganese dioxide were irradiated for about 20 minutes, followed by a 4 to 15 minutes decay and counted in a single channel pulse-height discrimination using a NaI(Tl) scintillation detector. Counting time was equal to 10 minutes. The interference of nuclear reactions {sup 56}Fe(n,p){sup 56}Mn and {sup 59} Co (n, {alpha}){sup 56} were studied, as well as problems in connection with neutron shadowing during irradiation, gamma-rays attenuation during counting and influence of granulometry of samples. One sample,was also analysed by wet-chemical method (sodium bismuthate) in order to compare results. As a whole, i t was shown that the analytical method of neutron activation for manganese in ores and blending, is a method simple, rapid and with good precision and accuracy. (author)

  7. Design of a homogeneous subcritical nuclear reactor based on thorium with a source of californium 252; Diseno de un reactor nuclear subcritico homogeneo a base de Torio con una fuente de Californio 252

    Energy Technology Data Exchange (ETDEWEB)

    Delgado H, C. E.; Vega C, H. R. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas, Zac. (Mexico); Sajo B, L., E-mail: ce_delgado89@hotmail.com [Universidad Simon Bolivar, Laboratorio de Fisica Nuclear, Apdo. 89000, 1080A Caracas (Venezuela, Bolivarian Republic of)

    2015-10-15

    Full text: One of the energy alternatives to fossil fuels which do not produce greenhouse gases is the nuclear energy. One of the drawbacks of this alternative is the generation of radioactive wastes of long half-life and its relation to the generation of nuclear materials to produce weapons of mass destruction. An option to these drawbacks of nuclear energy is to use Thorium as part of the nuclear fuel which it becomes in U{sup 233} when capturing neutrons, that is a fissile material. In this paper Monte Carlo methods were used to design a homogeneous subcritical reactor based on thorium. As neutron reflector graphite was used. The reactor core is homogeneous and is formed of 70% light water as moderator, 12% of enriched uranium UO{sub 2}(NO{sub 3}){sub 4} and 18% of thorium Th(NO{sub 3}){sub 4} as fuel. To start the nuclear fission chain reaction an isotopic source of californium 252 was used with an intensity of 4.6 x 10{sup 7} s{sup -1}. In the design the value of the effective multiplication factor, whose value turned out k{sub eff} <1 was calculated. Also, the neutron spectra at different distances from the source and the total fluence were calculated, as well as the values of the ambient dose equivalent in the periphery of the reactor. (Author)

  8. Aserisse kerkib 250 miljonit krooni maksev tellisetehas / Gerli Romanovitsh

    Index Scriptorium Estoniae

    Romanovitš, Gerli, 1977-

    2005-01-01

    Ilmunud ka: Põhjarannik 19. mai 2005, lk. 1, Severnoje Poberezhje 19. mai 2005, lk. 1,3. AS Wienerburger kavatseb rajada Aserisse 250 miljonit krooni maksva tellisetehase, vanas vabrikus hakatakse tootma keraamilisi plokke

  9. Alaska map quadrangles at 1:250,000 scale

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Outlines of 1:250,000 scale map quadrangles in Alaska for use as a geographic reference within Google Earth or other software capable of interpreting KML, with links...

  10. Superfund GIS - 1:250,000 Geology of Tennessee.

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set is a digital representation of the printed 1:250,000 geologic maps from the Tennessee Department of Environment and Conservation, Division of Geology....

  11. 50 CFR 600.250 - Council member training.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Council member training. 600.250 Section... member training. (a) The Secretary shall provide a training course covering a variety of topics relevant to matters before the Councils and shall make the training course available to all Council members...

  12. 30 CFR 250.198 - Documents incorporated by reference.

    Science.gov (United States)

    2010-07-01

    ..., Section 3—Concentric, Square-Edged Orifice Meters; Part 3—Natural Gas Applications; Third Edition, August... GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General References § 250.198 Documents...-642-4900; and/or American Society of Mechanical Engineers (ASME), 22 Law Drive, P.O. Box 2900...

  13. 6 CFR 27.250 - Inspections and audits.

    Science.gov (United States)

    2010-01-01

    ... Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Chemical Facility Security Program § 27.250 Inspections and audits. (a) Authority. In order to... conducting an inspection might be seriously detrimental to security, and the Director of the Chemical...

  14. 40 CFR 1042.250 - Recordkeeping and reporting.

    Science.gov (United States)

    2010-07-01

    ... for any engine family for which you produce engines after completing the reports required in § 1042... Certifying Engine Families § 1042.250 Recordkeeping and reporting. (a) Send the Designated Compliance Officer... engines you produced during the model year as follows: (1) State the total production volume for each...

  15. 40 CFR 1033.250 - Reporting and recordkeeping.

    Science.gov (United States)

    2010-07-01

    ... report describing the following information about locomotives you produced during the model year: (1) Report the total number of locomotives you produced in each engine family by locomotive model and engine... CONTROLS CONTROL OF EMISSIONS FROM LOCOMOTIVES Certifying Engine Families § 1033.250 Reporting and...

  16. 30 CFR 250.611 - Traveling-block safety device.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Traveling-block safety device. 250.611 Section... Traveling-block safety device. After May 31, 1989, all units being used for well-workover operations which have both a traveling block and a crown block shall be equipped with a safety device which is designed...

  17. 30 CFR 250.511 - Traveling-block safety device.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Traveling-block safety device. 250.511 Section... Traveling-block safety device. All units being used for well-completion operations that have both a traveling block and a crown block must be equipped with a safety device that is designed to prevent the...

  18. 21 CFR 173.250 - Methyl alcohol residues.

    Science.gov (United States)

    2010-04-01

    ... FOR HUMAN CONSUMPTION (CONTINUED) SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION Solvents, Lubricants, Release Agents and Related Substances § 173.250 Methyl alcohol residues... beer. (2) The label of the hops extract specifies the presence of methyl alcohol and provides for the...

  19. 30 CFR 250.1603 - Determination of sulphur deposit.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Determination of sulphur deposit. 250.1603... Determination of sulphur deposit. (a) Upon receipt of a written request from the lessee, the District Manager will determine whether a sulphur deposit has been defined that contains sulphur in paying quantities (i...

  20. 30 CFR 250.1007 - What to include in applications.

    Science.gov (United States)

    2010-07-01

    ... Section 250.1007 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL...); the rated working pressure, as specified by ANSI or API, of all valves, flanges, and fittings; the... standards you used; and (D) A review by a third-party independent verification agent (IVA) according to API...

  1. 30 CFR 250.803 - Additional production system requirements.

    Science.gov (United States)

    2010-07-01

    ....803 Section 250.803 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE....802 of this subpart and the requirements of API RP 14C (incorporated by reference as specified in 30... inspection, rating, repair, and alteration performed in accordance with the applicable provisions of API...

  2. 30 CFR 250.1616 - Supervision, surveillance, and training.

    Science.gov (United States)

    2010-07-01

    ... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1616 Supervision, surveillance, and training. (a) The lessee shall provide onsite supervision of drilling operations at all times. (b) From the time drilling operations are initiated and until the well is completed...

  3. 30 CFR 250.1615 - Securing of wells.

    Science.gov (United States)

    2010-07-01

    ... OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1615 Securing of wells. A downhole-safety device such as a cement plug, bridge plug, or packer shall be timely installed when drilling operations are interrupted by events such as those that force evacuation of the drilling crew, prevent station...

  4. 30 CFR 250.101 - Authority and applicability.

    Science.gov (United States)

    2010-07-01

    ... 250.101 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS... Management Service (MMS) to regulate oil, gas, and sulphur exploration, development, and production... competition; and (5) Minimize or eliminate conflicts between the exploration, development, and production of...

  5. 43 CFR 17.250 - Health, welfare, and social services.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Health, welfare, and social services. 17... § 17.250 Health, welfare, and social services. This subpart applies to health, welfare, and other social service programs or activities that receive Federal financial assistance and to recipients that...

  6. 38 CFR 3.250 - Dependency of parents; compensation.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Dependency of parents... ADJUDICATION Pension, Compensation, and Dependency and Indemnity Compensation Dependency, Income and Estate § 3.250 Dependency of parents; compensation. (a) Income—(1) Conclusive dependency. Dependency of a parent...

  7. 5 CFR 250.201 - Coverage and purpose.

    Science.gov (United States)

    2010-01-01

    ....201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT IN AGENCIES Strategic Human Capital Management § 250.201 Coverage and purpose. The Chief Human... effective and efficient operation of Government. As a part of OPM's overall leadership responsibilities in...

  8. 9 CFR 2.50 - Time and method of identification.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Time and method of identification. 2... AGRICULTURE ANIMAL WELFARE REGULATIONS Identification of Animals § 2.50 Time and method of identification. (a... , or shall be identified by a distinctive and legible tattoo marking acceptable to and approved by the...

  9. The Varian MAT-250 mass spectrometer. Steady isotopes laboratory; Espectrometro de masas Varian MAT-250. Laboratorio de isotopos estables

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez M, V.; Tavera D, M.L. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1997-07-01

    This work treats over the performance and applications of the Varian Mat-250 mass spectrometer which is in the environmental isotope laboratory. It can be applied over topics such as: ions formation, acceleration and collimation, ions separation, ions detection, data transformation, sampling, {delta} notation. (Author)

  10. Leptin Induces Hippocampal Synaptogenesis via CREB-Regulated MicroRNA-132 Suppression of p250GAP

    Science.gov (United States)

    Dhar, Matasha; Zhu, Mingyan; Impey, Soren; Lambert, Talley J.; Bland, Tyler; Karatsoreos, Ilia N.; Nakazawa, Takanobu

    2014-01-01

    Leptin acts in the hippocampus to enhance cognition and reduce depression and anxiety. Cognitive and emotional disorders are associated with abnormal hippocampal dendritic spine formation and synaptogenesis. Although leptin has been shown to induce synaptogenesis in the hypothalamus, its effects on hippocampal synaptogenesis and the mechanism(s) involved are not well understood. Here we show that leptin receptors (LepRs) are critical for hippocampal dendritic spine formation in vivo because db/db mice lacking the long form of the leptin receptor (LepRb) have reduced spine density on CA1 and CA3 neurons. Leptin promotes the formation of mature spines and functional glutamate synapses on hippocampal pyramidal neurons in both dissociated and slice cultures. These effects are blocked by short hairpin RNAs specifically targeting the LepRb and are absent in cultures from db/db mice. Activation of the LepR leads to cAMP response element–binding protein (CREB) phosphorylation and initiation of CREB-dependent transcription via the MAPK kinase/Erk pathway. Furthermore, both Mek/Erk and CREB activation are required for leptin-induced synaptogenesis. Leptin also increases expression of microRNA-132 (miR132), a well-known CREB target, which is also required for leptin-induced synaptogenesis. Last, leptin suppresses the expression of p250GAP, a miR132 target, and this suppression is obligatory for leptin's effects as is the downstream target of p250GAP, Rac1. LepRs appear to be critical in vivo as db/db mice have lowered hippocampal miR132 levels and elevated p250GAP expression. In conclusion, we identify a novel signaling pathway by which leptin increases synaptogenesis through inducing CREB transcription and increasing microRNA-mediated suppression of p250GAP activity, thus removing a known inhibitor of Rac1-stimulated synaptogenesis. PMID:24877561

  11. Target Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — [Part of the ATLAS user facility.] The Physics Division operates a target development laboratory that produces targets and foils of various thickness and substrates,...

  12. Heavy ion collisions. [250 to 1050 MeV/A

    Energy Technology Data Exchange (ETDEWEB)

    Siemens, P.J.

    1979-12-01

    The status of research into collisions of nuclei at high energy is reviewed. Reactions and products are classified, and spectator matter is discussed. Then the thermalization of participant matter is considered at some length. Finally, disintegration of the hot matter is addressed. A = 20 and 40 projectiles of 250 to 1050 MeV/A are employed to illustrate the major points. 44 references, 10 figures. (RWR)

  13. Towards 250 m mapping of terrestrial primary productivity over Canada

    Science.gov (United States)

    Gonsamo, A.; Chen, J. M.

    2011-12-01

    Terrestrial ecosystems are an important part of the climate and global change systems. Their role in climate change and in the global carbon cycle is yet to be well understood. Dataset from satellite earth observation, coupled with numerical models provide the unique tools for monitoring the spatial and temporal dynamics of territorial carbon cycle. The Boreal Ecosystems Productivity Simulator (BEPS) is a remote sensing based approach to quantifying the terrestrial carbon cycle by that gross and net primary productivity (GPP and NPP) and terrestrial carbon sinks and sources expressed as net ecosystem productivity (NEP). We have currently implemented a scheme to map the GPP, NPP and NEP at 250 m for first time over Canada using BEPS model. This is supplemented by improved mapping of land cover and leaf area index (LAI) at 250 m over Canada from MODIS satellite dataset. The results from BEPS are compared with MODIS GPP product and further evaluated with estimated LAI from various sources to evaluate if the results capture the trend in amount of photosynthetic biomass distributions. Final evaluation will be to validate both BEPS and MODIS primary productivity estimates over the Fluxnet sites over Canada. The primary evaluation indicate that BEPS GPP estimates capture the over storey LAI variations over Canada very well compared to MODIS GPP estimates. There is a large offset of MODIS GPP, over-estimating the lower GPP value compared to BEPS GPP estimates. These variations will further be validated based on the measured values from the Fluxnet tower measurements over Canadian. The high resolution GPP (NPP) products at 250 m will further be used to scale the outputs between different ecosystem productivity models, in our case the Canadian carbon budget model of Canadian forest sector CBM-CFS) and the Integrated Terrestrial Ecosystem Carbon model (InTEC).

  14. 250 år - rejsen fortsætter

    DEFF Research Database (Denmark)

    Jacobsen, Brian Arly

    2011-01-01

    I 1761 sendte Kong Frederik 5 en videnskabelig ekspedition til den arabiske halvø, der dengang var ukendt land for europæerne. I ekspeditionen deltog seks personer, en tysk geodæt og astronom (Carsten Niebuhr), en dansk filolog (Frederik Christian von Haven), en svensk botaniker og naturforsker (...... (Peter Forsskål), en dansk læge (Christian Carl Kramer) og en kobberstikker (Georg Wilhelm Baurenfeind) samt en oppasser (den svenske dragon Lars Berggren). Kun geodæten og astronomen, Carsten Niebuhr, gennemførte og overlevede rejsen. Læs mere om 250-års-jubilæet på denne hjemmeside....

  15. 30 CFR 250.109 - What documents must I prepare and maintain related to welding?

    Science.gov (United States)

    2010-07-01

    ... related to welding? 250.109 Section 250.109 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF... Performance Standards § 250.109 What documents must I prepare and maintain related to welding? (a) You must submit a Welding Plan to the District Manager before you begin drilling or production activities on a...

  16. 41 CFR 102-117.250 - What are my responsibilities after shipping the household goods?

    Science.gov (United States)

    2010-07-01

    ... responsibilities after shipping the household goods? 102-117.250 Section 102-117.250 Public Contracts and Property... TRANSPORTATION 117-TRANSPORTATION MANAGEMENT Shipping Household Goods § 102-117.250 What are my responsibilities after shipping the household goods? (a) Each agency should develop an evaluation survey for the employee...

  17. 30 CFR 250.455 - What are the general requirements for a drilling fluid program?

    Science.gov (United States)

    2010-07-01

    ... drilling fluid program? 250.455 Section 250.455 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT... Gas Drilling Operations Drilling Fluid Requirements § 250.455 What are the general requirements for a drilling fluid program? You must design and implement your drilling fluid program to prevent the loss of...

  18. 17 CFR 250.26 - Financial statement and recordkeeping requirements for registered holding companies and...

    Science.gov (United States)

    2010-04-01

    ..., except that it is unnecessary to file a copy of an official chart of accounts which any company subject... recordkeeping requirements for registered holding companies and subsidiaries. 250.26 Section 250.26 Commodity..., PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 Forms, Procedure and Accounts § 250.26 Financial statement and...

  19. 21 CFR 250.201 - Preparations for the treatment of pernicious anemia.

    Science.gov (United States)

    2010-04-01

    ... anemia. 250.201 Section 250.201 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... Drugs and Foods § 250.201 Preparations for the treatment of pernicious anemia. (a) The ninth announcement of the Anti-anemia Preparations Advisory Board of the United States Pharmacopeia is concerned with...

  20. 30 CFR 250.1159 - May the Regional Supervisor limit my well or reservoir production rates?

    Science.gov (United States)

    2010-07-01

    ... reservoir production rates? 250.1159 Section 250.1159 Mineral Resources MINERALS MANAGEMENT SERVICE... Gas Production Requirements Production Rates § 250.1159 May the Regional Supervisor limit my well or reservoir production rates? (a) The Regional Supervisor may set a Maximum Production Rate (MPR) for a...

  1. 32 CFR 250.8 - Pertinent portions of International Traffic in Arms Regulations (ITAR).

    Science.gov (United States)

    2010-07-01

    ... Arms Regulations (ITAR). 250.8 Section 250.8 National Defense Department of Defense (Continued) OFFICE... PUBLIC DISCLOSURE § 250.8 Pertinent portions of International Traffic in Arms Regulations (ITAR). The... releasibility of technical data under the authority of this part. International Traffic in Arms Regulations 22...

  2. 30 CFR 250.226 - What Coastal Zone Management Act (CZMA) information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What Coastal Zone Management Act (CZMA) information must accompany the EP? 250.226 Section 250.226 Mineral Resources MINERALS MANAGEMENT SERVICE... and Information Contents of Exploration Plans (ep) § 250.226 What Coastal Zone Management Act (CZMA...

  3. 30 CFR 250.184 - What is the amount of compensation for lease cancellation?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What is the amount of compensation for lease cancellation? 250.184 Section 250.184 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... Requirements, Lease Term Extensions, and Lease Cancellations § 250.184 What is the amount of compensation for...

  4. 17 CFR 250.110 - Small entities for purposes of the Regulatory Flexibility Act.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Small entities for purposes of the Regulatory Flexibility Act. 250.110 Section 250.110 Commodity and Securities Exchanges SECURITIES... OF 1935 Miscellaneous Rules § 250.110 Small entities for purposes of the Regulatory Flexibility Act...

  5. 30 CFR 250.1501 - What is the goal of my training program?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What is the goal of my training program? 250.1501 Section 250.1501 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... Safety Training § 250.1501 What is the goal of my training program? The goal of your training program...

  6. 30 CFR 250.901 - What industry standards must your platform meet?

    Science.gov (United States)

    2010-07-01

    ...? 250.901 Section 250.901 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR...) American Petroleum Institute (API) Bulletin 2INT-DG, Interim Guidance for Design of Offshore Structures for Hurricane Conditions, (incorporated by reference as specified in § 250.198); (5) API Bulletin 2INT-EX...

  7. 30 CFR 250.527 - What must I include in my casing pressure request?

    Science.gov (United States)

    2010-07-01

    ... request? 250.527 Section 250.527 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... Operations Casing Pressure Management § 250.527 What must I include in my casing pressure request? The following information must be included in the casing pressure request: (a) API number; (b) Lease number; (c...

  8. 30 CFR 250.518 - What are the requirements for casing pressure management?

    Science.gov (United States)

    2010-07-01

    ... Operations Casing Pressure Management § 250.518 What are the requirements for casing pressure management? Once you install your wellhead, you must meet the casing pressure management requirements of API RP 90... management? 250.518 Section 250.518 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR...

  9. 30 CFR 250.526 - What must I include in my notification of corrective action?

    Science.gov (United States)

    2010-07-01

    ... corrective action? 250.526 Section 250.526 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE...-Completion Operations Casing Pressure Management § 250.526 What must I include in my notification of... Operator name; (b) Area name and OCS block number; (c) Well name and API number; and (d) Casing diagnostic...

  10. 30 CFR 250.424 - What are the requirements for prolonged drilling operations?

    Science.gov (United States)

    2010-07-01

    ... drilling operations? 250.424 Section 250.424 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF... Drilling Operations Casing and Cementing Requirements § 250.424 What are the requirements for prolonged drilling operations? If wellbore operations continue for more than 30 days within a casing string run to...

  11. 30 CFR 250.408 - May I use alternative procedures or equipment during drilling operations?

    Science.gov (United States)

    2010-07-01

    ... during drilling operations? 250.408 Section 250.408 Mineral Resources MINERALS MANAGEMENT SERVICE... Gas Drilling Operations General Requirements § 250.408 May I use alternative procedures or equipment during drilling operations? You may use alternative procedures or equipment during drilling operations...

  12. 21 CFR 250.105 - Gelsemium-containing preparations regarded as prescription drugs.

    Science.gov (United States)

    2010-04-01

    ... or Prescription Status of Specific Drugs § 250.105 Gelsemium-containing preparations regarded as prescription drugs. It is the consensus of informed medical opinion that the margin of safety between the... prescription drugs. 250.105 Section 250.105 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH...

  13. 21 CFR 250.108 - Potassium permanganate preparations as prescription drugs.

    Science.gov (United States)

    2010-04-01

    ... or Prescription Status of Specific Drugs § 250.108 Potassium permanganate preparations as prescription drugs. (a) There have been a number of reports in the medical literature of serious injuries to... prescription drugs. 250.108 Section 250.108 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH...

  14. 30 CFR 250.802 - Design, installation, and operation of surface production-safety systems.

    Science.gov (United States)

    2010-07-01

    ... production-safety systems. 250.802 Section 250.802 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT... Gas Production Safety Systems § 250.802 Design, installation, and operation of surface production-safety systems. (a) General. All production facilities, including separators, treaters, compressors...

  15. 7 CFR 250.52 - Storage and inventory management of donated foods.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Storage and inventory management of donated foods. 250... Donated Foods in Contracts With Food Service Management Companies § 250.52 Storage and inventory... general requirements in § 250.14(b) for the storage and inventory management of donated foods. (b) Storage...

  16. 30 CFR 250.246 - What mineral resource conservation information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What mineral resource conservation information must accompany the DPP or DOCD? 250.246 Section 250.246 Mineral Resources MINERALS MANAGEMENT SERVICE... Coordination Documents (docd) § 250.246 What mineral resource conservation information must accompany the DPP...

  17. 27 CFR 24.250 - Application for use of new treating material or process.

    Science.gov (United States)

    2010-04-01

    ... treating material or process. 24.250 Section 24.250 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS WINE Storage, Treatment and Finishing of Wine § 24.250 Application for use of new treating material or process. (a) General. If the proprietor...

  18. 33 CFR 148.250 - Who must be served before a document is filed?

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Who must be served before a document is filed? 148.250 Section 148.250 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Hearings § 148.250 Who must be served before a document is filed? Before a document may be filed by any...

  19. Bayesian demography 250 years after Bayes.

    Science.gov (United States)

    Bijak, Jakub; Bryant, John

    2016-01-01

    Bayesian statistics offers an alternative to classical (frequentist) statistics. It is distinguished by its use of probability distributions to describe uncertain quantities, which leads to elegant solutions to many difficult statistical problems. Although Bayesian demography, like Bayesian statistics more generally, is around 250 years old, only recently has it begun to flourish. The aim of this paper is to review the achievements of Bayesian demography, address some misconceptions, and make the case for wider use of Bayesian methods in population studies. We focus on three applications: demographic forecasts, limited data, and highly structured or complex models. The key advantages of Bayesian methods are the ability to integrate information from multiple sources and to describe uncertainty coherently. Bayesian methods also allow for including additional (prior) information next to the data sample. As such, Bayesian approaches are complementary to many traditional methods, which can be productively re-expressed in Bayesian terms.

  20. Remote (250 km Fiber Bragg Grating Multiplexing System

    Directory of Open Access Journals (Sweden)

    Manuel Lopez-Amo

    2011-09-01

    Full Text Available We propose and demonstrate two ultra-long range fiber Bragg grating (FBG sensor interrogation systems. In the first approach four FBGs are located 200 km from the monitoring station and a signal to noise ratio of 20 dB is obtained. The second improved version is able to detect the four multiplexed FBGs placed 250 km away, offering a signal to noise ratio of 6–8 dB. Consequently, this last system represents the longest range FBG sensor system reported so far that includes fiber sensor multiplexing capability. Both simple systems are based on a wavelength swept laser to scan the reflection spectra of the FBGs, and they are composed by two identical-lengths optical paths: the first one intended to launch the amplified laser signal by means of Raman amplification and the other one is employed to guide the reflection signal to the reception system.

  1. Antiproton Target

    CERN Multimedia

    1980-01-01

    Antiproton target used for the AA (antiproton accumulator). The first type of antiproton production target used from 1980 to 1982 comprised a rod of copper 3mm diameter and 120mm long embedded in a graphite cylinder that was itself pressed into a finned aluminium container. This assembly was air-cooled and it was used in conjunction with the Van der Meer magnetic horn. In 1983 Fermilab provided us with lithium lenses to replace the horn with a view to increasing the antiproton yield by about 30%. These lenses needed a much shorter target made of heavy metal - iridium was chosen for this purpose. The 50 mm iridium rod was housed in an extension to the original finned target container so that it could be brought very close to the entrance to the lithium lens. Picture 1 shows this target assembly and Picture 2 shows it mounted together with the lithium lens. These target containers had a short lifetime due to a combination of beam heating and radiation damage. This led to the design of the water-cooled target in...

  2. The Undergraduate ALFALFA Team: Outcomes for Over 250 Undergraduate Participants

    Science.gov (United States)

    Troischt, Parker; Koopmann, Rebecca A.; Haynes, Martha P.; ALFALFA Team

    2016-01-01

    The NSF-sponsored Undergraduate ALFALFA (Arecibo Legacy Fast ALFA) Team (UAT) is a consortium of 19 institutions founded to promote undergraduate research and faculty development within the extragalactic ALFALFA HI blind survey project and follow-up programs. In this talk we present outcomes for the more than 250 undergraduate students who have who have participated in the program during the 8 years of funding. 40% of these students have been women and members of underrepresented groups. To date 148 undergraduate students have attended annual workshops at Arecibo Observatory, interacting with faculty, graduate students, their peers, and Arecibo staff in lectures, group activities, tours, and observing runs. Team faculty have supervised 159 summer research projects and 120 academic year (e.g., senior thesis) projects. 68 students have traveled to Arecibo Observatory for observing runs and 55 have presented their results at national meetings such as the AAS. Through participation in the UAT, students are made aware of career paths they may not have previously considered. More than 90% of alumni are attending graduate school and/or pursuing a career in STEM. 42% of those pursuing graduate degrees in Physics or Astronomy are women. This work has been supported by NSF grants AST-0724918/0902211, AST-075267/0903394, AST-0725380, and AST-1211005

  3. Grammaire pour adolescents 250 exercices : niveau débutant

    CERN Document Server

    Bié, Nathalie

    2005-01-01

    Ce nouveau livre d'exercices de grammaire, de la collection Le Nouvel Entraînez-vous, s'adresse à un public d'adolescents débutants et faux débutants en français langue étrangère. L'ouvrage propose 250 exercices de compréhension et de mémorisation à travers des activités de déduction et de réemploi des notions grammaticales étudiées. Le contenu des exercices est organisé autour de contextes langagiers proches de la réalité des adolescents afin de placer la communication au cœur de l'apprentissage. L'introduction des contenus grammaticaux suit la même progression que les méthodes usuelles. Chaque chapitre débute par une séquence Rappel permettant à l'apprenant de revoir rapidement les règles grammaticales développées dans les exercices. Chaque exercice est introduit par une consigne brève et concise accompagnée d'un exemple. L'ouvrage a été conçu en tenant compte des centres d'intérêts des adolescents et propose de nombreuses illustrations intégrées aux exercices. A la fin d...

  4. Modeling global Hammond landform regions from 250-m elevation data

    Science.gov (United States)

    Karagulle, Deniz; Frye, Charlie; Sayre, Roger; Breyer, Sean P.; Aniello, Peter; Vaughan, Randy; Wright, Dawn J.

    2017-01-01

    In 1964, E.H. Hammond proposed criteria for classifying and mapping physiographic regions of the United States. Hammond produced a map entitled “Classes of Land Surface Form in the Forty-Eight States, USA”, which is regarded as a pioneering and rigorous treatment of regional physiography. Several researchers automated Hammond?s model in GIS. However, these were local or regional in application, and resulted in inadequate characterization of tablelands. We used a global 250 m DEM to produce a new characterization of global Hammond landform regions. The improved algorithm we developed for the regional landform modeling: (1) incorporated a profile parameter for the delineation of tablelands; (2) accommodated negative elevation data values; (3) allowed neighborhood analysis window (NAW) size to vary between parameters; (4) more accurately bounded plains regions; and (5) mapped landform regions as opposed to discrete landform features. The new global Hammond landform regions product builds on an existing global Hammond landform features product developed by the U.S. Geological Survey, which, while globally comprehensive, did not include tablelands, used a fixed NAW size, and essentially classified pixels rather than regions. Our algorithm also permits the disaggregation of “mixed” Hammond types (e.g. plains with high mountains) into their component parts.

  5. Bionics by examples 250 scenarios from classical to modern times

    CERN Document Server

    Nachtigall, Werner

    2015-01-01

    Bionics means learning from the nature for the development of technology. The science of "bionics" itself is classified into several sections, from materials and structures over procedures and processes until evolution and optimization. Not all these areas, or only a few, are really known in the public and also in scientific literature. This includes the Lotus-effect, converted to the contamination-reduction of fassades and the shark-shed-effect, converted to the  resistance-reduction of airplanes. However, there are hundreds of highly interesting examples that contain the transformation of principles of the nature into technology. From the large number of these examples, 250 were selected for the present book according to "prehistory", "early-history", "classic" and "modern time". Most examples are new. Every example includes a printed page in a homogeneous arrangement. The examples from the field "modern time" are joint in blocks corresponding to the sub-disciplines of bionics.

  6. Targeted Learning

    CERN Document Server

    van der Laan, Mark J

    2011-01-01

    The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the targe

  7. 250 labels used to stigmatise people with mental illness

    Directory of Open Access Journals (Sweden)

    Pinfold Vanessa

    2007-06-01

    Full Text Available Abstract Background The stigma against people with mental illness is a major barrier to help-seeking in young people for mental health problems. The objective of this study was to investigate the extent of stigma in relation to treatment avoidance in 14 year-old school students in England in relation to how they refer to people with mental illness. Methods This is a qualitative, cross-sectional study. The data were gathered as part of the baseline assessment for an intervention study intended to reduce stigma among 14 year old school students. The participating schools were two grammar (selective schools and three comprehensive (non-selective schools. At the start of the lesson, the students were asked 'What sorts of words or phrases might you use to describe someone who experiences mental health problems?' Words and terms used to refer to mental illness were enumerated. Using the grounded theory approach, words and terms were grouped in terms of their denotative and connotative meanings. Labels were then derived to capture the key themes attached by the students to the concepts of mental illness. The frequencies of occurrence for each word were also tabulated. Results 400 of the 472 participating students (85% provided 250 words and terms to describe a person with mental illness. Five themes were identified from the data. The first theme called 'popular derogatory terms' (116 items accounted for nearly half of the words examined. The second theme occurred less often and was described as 'negative emotional state' (61 items. The third theme demonstrated the confusion of young people between physical disabilities, learning difficulties and mental health problems (38 items. The use of psychiatric diagnoses (15 items and terms related to violence (9 items were unexpectedly uncommon. Conclusion Our findings suggest the hypothesis that help-seeking by mentally ill young people may be improved by interventions that address both their lack of factual

  8. BAF250a Expression in Atypical Endometriosis and Endometriosis-Associated Ovarian Cancer.

    Science.gov (United States)

    Stamp, John P; Gilks, C Blake; Wesseling, Martine; Eshragh, Sima; Ceballos, Kathy; Anglesio, Michael S; Kwon, Janice S; Tone, Alicia; Huntsman, David G; Carey, Mark S

    2016-06-01

    Atypical endometriosis (AE) is thought to be a precursor lesion to the ovarian cancer subtypes associated with endometriosis, namely, endometrioid and clear cell carcinomas. ARID1A encodes a nuclear protein (BAF250a) governing chromatin remodeling, and mutations in ARID1A have been found in 30% to 50% of clear cell and endometrioid ovarian cancers. As BAF250a expression loss by immunohistochemistry (IHC) has been documented in the endometriosis precursor lesions closely associated with these ovarian cancers subtypes, our goal was to further study the association between BAF250a expression in cases of AE with and without an associated cancer. Three separate databases were screened for suspected cases of AE. Based on a detailed review of the pathology reports, we selected cases likely to contain AE for slide review. After slide review, tissue blocks were recalled to perform IHC for BAF250a in the associated cancer, AE, or typical endometriosis when present. There were 35 cases of endometriosis-associated cancer and 8 cases of AE not associated with cancer. Atypical endometriosis was found on pathology review in 23 endometriosis-associated cancer cases (66%). In the 35 cancer cases, BAF250a IHC showed loss of expression in 14 cases. Atypical endometriosis was present in 10 of these cases, 6 of which showed BAF250a loss (60%). BAF250a loss was not observed in the 8 cases of AE not associated with cancer or in the contiguous AE of 13 cases, whereby BAF250a expression was retained in the associated cancer. BAF250a loss in AE is consistently associated with the development of BAF250a-negative endometriosis-associated cancers and appears to be an early event in most of these cases. This research provides additional evidence that in the absence of cancer, BAF250a expression should be evaluated as a biomarker of cancer risk in patients diagnosed with AE.

  9. 30 CFR 250.1158 - How do I receive approval to downhole commingle hydrocarbons?

    Science.gov (United States)

    2010-07-01

    ... hydrocarbons? 250.1158 Section 250.1158 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... hydrocarbons? (a) Before you perforate a well, you must request and receive approval from the Regional Supervisor to commingle hydrocarbons produced from multiple reservoirs within a common wellbore. The Regional...

  10. 41 CFR 102-33.250 - May we report as excess, or replace, declassified aircraft?

    Science.gov (United States)

    2010-07-01

    ... parts or other property” on your property records under the appropriate Federal Supply Classification... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false May we report as excess, or replace, declassified aircraft? 102-33.250 Section 102-33.250 Public Contracts and Property...

  11. 41 CFR 60-250.44 - Required contents of affirmative action programs.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Required contents of affirmative action programs. 60-250.44 Section 60-250.44 Public Contracts and Property Management Other... career days, youth motivation programs, and related activities in their communities. (6) The contractor...

  12. 30 CFR 250.428 - What must I do in certain cementing and casing situations?

    Science.gov (United States)

    2010-07-01

    ... situations? 250.428 Section 250.428 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR...) Have unexpected formation pressures or conditions that warrant revising your casing design Submit a... these techniques. (d) Inadequate cement job Re-cement or take other remedial actions as approved by the...

  13. Galvanic interactions of HE15 /MDN138 & HE15 /MDN250 alloys in natural seawater

    Science.gov (United States)

    Parthiban, G. T.; Subramanian, G.; Muthuraman, K.; Ramakrishna Rao, P.

    2017-06-01

    HE15 is a heat treatable high strength alloy with excellent machinability find wide applications in aerospace and defence industries. In view of their excellent mechanical properties, workability, machinability, heat treatment characteristics and good resistance to general and stress corrosion cracking, MDN138 & MDN250 have been widely used in petrochemical, nuclear and aerospace industries. The galvanic corrosion behaviour of the metal combinations HE15 /MDN138 and HE15 /MDN250, with 1:1 area ratio, has been studied in natural seawater using the open well facility of CECRI's Offshore Platform at Tuticorin for a year. The open circuit potentials of MDN138, MDN250 and HE15 of the individual metal, the galvanic potential and galvanic current of the couples HE15 /MDN138 and HE15 /MDN250 were periodically monitored throughout the study period. The calcareous deposits on MDN138 and MDN250 in galvanic contact with HE15 were analyzed using XRD. The electrochemical behaviors of MDN138, MDN250 and HE15 in seawater have been studied using an electrochemical work station. The surface characteristics of MDN138 and MDN250 in galvanic contact with HE15 have been examined with scanning electron microscope. The results of the study reveal that HE15 offered required amount of protection to MDN138 & MDN250.

  14. 17 CFR 250.2 - Exemption of holding companies which are intrastate or predominantly operating companies.

    Science.gov (United States)

    2010-04-01

    ... holding company need file only the initial statement on Form U-3A-2. ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exemption of holding companies which are intrastate or predominantly operating companies. 250.2 Section 250.2 Commodity and Securities...

  15. 17 CFR 250.5 - Exemption of certain foreign holding companies.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exemption of certain foreign... and General Exemptions § 250.5 Exemption of certain foreign holding companies. Any holding company not... of the issuer, except an issuer within any class specified in § 250.10(a). ...

  16. 17 CFR 250.8 - Exemption of subsidiaries subject to jurisdiction of Interstate Commerce Commission.

    Science.gov (United States)

    2010-04-01

    ... subject to jurisdiction of Interstate Commerce Commission. 250.8 Section 250.8 Commodity and Securities... to jurisdiction of Interstate Commerce Commission. Any subsidiary company of a registered holding company, which subsidiary is subject to the jurisdiction of the Interstate Commerce Commission but is not...

  17. 17 CFR 250.7 - Companies deemed not to be electric or gas utility companies.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Companies deemed not to be electric or gas utility companies. 250.7 Section 250.7 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935...

  18. 41 CFR Appendix A to Part 61 - 250-Federal Contractor Veterans' Employment Report VETS-100

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true 250-Federal Contractor Veterans' Employment Report VETS-100 A Appendix A to Part 61 Public Contracts and Property Management Other... Appendix A to Part 61-250—Federal Contractor Veterans' Employment Report VETS-100 ER05NO08.000 ER05NO08.001...

  19. 17 CFR 250.40 - Exemption of certain acquisitions from nonaffiliates.

    Science.gov (United States)

    2010-04-01

    ... securities of the class acquired. (b) Section 9(a) (49 Stat. 817; 15 U.S.C. 79i) shall not apply to the... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exemption of certain acquisitions from nonaffiliates. 250.40 Section 250.40 Commodity and Securities Exchanges SECURITIES AND...

  20. 17 CFR 250.49 - Certain exemptions granted to non-utility subsidiaries.

    Science.gov (United States)

    2010-04-01

    ... the Act (49 Stat. 814; 15 U.S.C. 79f) with respect to the issuance or sale of any securities to the... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Certain exemptions granted to non-utility subsidiaries. 250.49 Section 250.49 Commodity and Securities Exchanges SECURITIES AND...

  1. 30 CFR 250.921 - How do I analyze my platform for cumulative fatigue?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I analyze my platform for cumulative fatigue? 250.921 Section 250.921 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... fatigue? (a) If you are required to analyze cumulative fatigue on your platform because of the results of...

  2. 30 CFR 250.806 - Safety and pollution prevention equipment quality assurance requirements.

    Science.gov (United States)

    2010-07-01

    ... quality assurance requirements. 250.806 Section 250.806 Mineral Resources MINERALS MANAGEMENT SERVICE... of Safety and Pollution Prevention Equipment Used in Offshore Oil and Gas Operations; and (ii) API... specifications of API Spec 6A and 6AV1. All SSSVs must meet the technical specifications of API Specification 14A...

  3. 30 CFR 250.1630 - Safety-system testing and records.

    Science.gov (United States)

    2010-07-01

    ... Section 250.1630 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL.... Testing must be in accordance with API RP 14C, Appendix D (incorporated by reference as specified in § 250.198). For safety system devices other than those listed in API RP 14C, Appendix D, you must utilize...

  4. 30 CFR 250.1629 - Additional production and fuel gas system requirements.

    Science.gov (United States)

    2010-07-01

    ... requirements. 250.1629 Section 250.1629 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE..., repair, and alteration performed in accordance with the applicable provisions of API Pressure Vessel Inspections Code: In-Service Inspection, Rating, Repair, and Alteration, API 510 (except Sections 5.8 and 9.5...

  5. 30 CFR 250.446 - What are the BOP maintenance and inspection requirements?

    Science.gov (United States)

    2010-07-01

    ....11, Maintenance; and Sections 17.12 and 18.12, Quality Management, described in API RP 53... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the BOP maintenance and inspection requirements? 250.446 Section 250.446 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR...

  6. 30 CFR 250.920 - What are the MMS requirements for assessment of fixed platforms?

    Science.gov (United States)

    2010-07-01

    ... fixed platforms? 250.920 Section 250.920 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF... in API RP 2A-WSD, Section 17.3. If MMS objects to the assessment category you used for your... (see Sections 17.2.1 through 17.2.5 of API RP 2A-WSD for a description of assessment initiators). (c...

  7. 30 CFR 250.804 - Production safety-system testing and records.

    Science.gov (United States)

    2010-07-01

    .... 250.804 Section 250.804 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... or more frequently if operating conditions warrant. Testing must be in accordance with API RP 14C... removed, repaired and reinstalled, or replaced. Testing shall be in accordance with API RP 14B to ensure...

  8. 30 CFR 250.459 - What are the safety requirements for drilling fluid-handling areas?

    Science.gov (United States)

    2010-07-01

    ... fluid-handling areas? 250.459 Section 250.459 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT... drilling fluid-handling areas? You must classify drilling fluid-handling areas according to API RP 500... API RP 505, Recommended Practice for Classification of Locations for Electrical Installations at...

  9. 30 CFR 250.114 - How must I install and operate electrical equipment?

    Science.gov (United States)

    2010-07-01

    ... equipment? 250.114 Section 250.114 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR.... (a) You must classify all areas according to API RP 500, Recommended Practice for Classification of... Division 2, or API RP 505, Recommended Practice for Classification of Locations for Electrical...

  10. 30 CFR 250.1628 - Design, installation, and operation of production systems.

    Science.gov (United States)

    2010-07-01

    ... production systems. 250.1628 Section 250.1628 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF... allowable working pressures as determined in accordance with API RP 14E, Recommended Practice for Design and... of each platform deck, outlining all hazardous areas classified according to API RP 500, Recommended...

  11. 30 CFR 250.403 - What drilling unit movements must I report?

    Science.gov (United States)

    2010-07-01

    ... OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations General Requirements § 250.403 What drilling unit movements must I report? (a) You must report the... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What drilling unit movements must I report? 250...

  12. 30 CFR 250.1625 - Blowout preventer system testing, records, and drills.

    Science.gov (United States)

    2010-07-01

    ... continuing operations in cases where cement is not drilled out; (3) At least once each week, but not... not functional, further drilling operations shall be suspended until that system becomes operable. A... drills. 250.1625 Section 250.1625 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE...

  13. 30 CFR 250.422 - When may I resume drilling after cementing?

    Science.gov (United States)

    2010-07-01

    ... OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Casing and Cementing Requirements § 250.422 When may I resume drilling after cementing? (a) After... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When may I resume drilling after cementing? 250...

  14. 30 CFR 250.414 - What must my drilling prognosis include?

    Science.gov (United States)

    2010-07-01

    ... OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.414 What must my drilling prognosis include? Your drilling prognosis... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must my drilling prognosis include? 250...

  15. 30 CFR 250.1506 - How often must I train my employees?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How often must I train my employees? 250.1506... Training § 250.1506 How often must I train my employees? You determine the frequency of the training you provide your employees. You must do all of the following: (a) Provide periodic training to ensure that...

  16. 30 CFR 250.1505 - Where may I get training for my employees?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Where may I get training for my employees? 250... Safety Training § 250.1505 Where may I get training for my employees? You may get training from any source that meets the requirements of your training plan. ...

  17. 30 CFR 250.288 - When and how must I submit the Conceptual Plan?

    Science.gov (United States)

    2010-07-01

    ... you have decided on the general concept(s) for development and before you begin engineering design of... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When and how must I submit the Conceptual Plan? 250.288 Section 250.288 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR...

  18. 7 CFR 250.59 - Storage and inventory management of donated foods.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Storage and inventory management of donated foods. 250... National School Lunch Program (NSLP) and Other Child Nutrition Programs § 250.59 Storage and inventory management of donated foods. (a) General requirements. Distributing agencies, subdistributing agencies, and...

  19. 48 CFR 52.250-3 - SAFETY Act Block Designation/Certification.

    Science.gov (United States)

    2010-10-01

    ..., injury or other loss to citizens or institutions of the United States. Block certification means SAFETY... homeland security may be deemed a technology. SAFETY Act certification means a determination by DHS... Designation/Certification. 52.250-3 Section 52.250-3 Federal Acquisition Regulations System FEDERAL...

  20. 30 CFR 250.1507 - How will MMS measure training results?

    Science.gov (United States)

    2010-07-01

    ... how effective the training was. (c) Employee or contract personnel testing. MMS or its authorized... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How will MMS measure training results? 250.1507... Training § 250.1507 How will MMS measure training results? MMS may periodically assess your training...

  1. 12 CFR 250.182 - Terms defining competitive effects of proposed mergers.

    Science.gov (United States)

    2010-01-01

    ... mergers. 250.182 Section 250.182 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS... competitive effects of proposed mergers. Under the Bank Merger Act (12 U.S.C. 1828(c)), a Federal Banking agency receiving a merger application must request the views of the other two banking agencies and the...

  2. 30 CFR 250.401 - What must I do to keep wells under control?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I do to keep wells under control? 250... General Requirements § 250.401 What must I do to keep wells under control? You must take necessary precautions to keep wells under control at all times. You must: (a) Use the best available and safest drilling...

  3. 30 CFR 250.154 - What identification signs must I display?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What identification signs must I display? 250... Facilities and Wells (does Not Include Modus) § 250.154 What identification signs must I display? (a) You... maintained in a legible condition. (1) You must display an identification sign that can be viewed from the...

  4. UOP PSY 250 Week 5 Person-Situation Interactions (2 Papers) NEW

    OpenAIRE

    UOP PSY 250

    2017-01-01

    UOP PSY 250 Week 5 Person-Situation Interactions (2 Papers) NEW Check this A+ tutorial guideline at http://www.assignmentcloud.com/psy-250-uop/psy-250-week-5-person-situation-interactions-new For more classes visit http://www.assignmentcloud.com Write a 700- to 1,050-word paper analyzing the humanistic approaches to personality. Your paper should cover the following areas: § Compare person-centered theory with Maslow’s hierarchy of needs. § Use Maslow’s hiera...

  5. Assessment of nuclear-reaction codes for proton-induced reactions on light nuclei below 250 MeV

    Science.gov (United States)

    Braunn, Benjamin; Boudard, Alain; David, Jean-Christophe; Koning, Arjan J.; Leprince, Anne; Leray, Sylvie; Mancusi, Davide

    2015-07-01

    We assess the suitability of nuclear-reaction codes for the generation of accurate cross-section libraries targeted at the simulation of the transport of high-energy protons (up to 250 MeV) in the human body, or in any material containing light nuclides. To this end we present an extensive study of elastic, reaction and fragmentation cross sections for proton-induced reactions on several nuclides. We compare TALYS evaluations against experimental data and, wherever applicable, against the predictions of the INCL/ABLA07 nuclear-reaction model. The TALYS evaluations have been cast in the form of a new cross-section library, which also includes evaluated proton-proton cross sections based on the NN-OnLine tool.

  6. COST OF ADDRESSING TARGETS OF UNEQUAL VALUE

    Energy Technology Data Exchange (ETDEWEB)

    G.H. CANAVAN

    2001-08-01

    The formalism for evaluating first strike costs and incentives for military targeting generalize to include higher value targets. That introduces two new allocations to the usual allocation between missiles and military targets, but they can be performed analytically. As the number of weapons on each side decreases, the optimal fraction of second strike weapons allocated to military values falls. The shift to high value targets is more pronounced below about 1,000 weapons for nominal parameters. Below 500 weapons the first striker's cost of action drops below its cost of inaction. A strike would induce a second strike of about 250 weapons on high value targets. An increase in the first striker's preference for damage to the other's high value targets increases or a decrease in its preference for preventing damage to its own high value targets decreases first strike costs and stability margins. Including defenses complicates allocations slightly. The main effect is increased attrition of second strikes, particularly at larger defenses, which makes it possible to significantly reduce damage to high value targets. At 1,000 weapons, by 300 to 400 interceptors the first striker's costs are reduced to 30% below that of inaction and the number of weapons delivered on the first striker's high value targets is reduced to about 100.

  7. 1:250,000-scale geology of the Carson River Basin, Nevada and California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digital continuous geologic data for the Carson River Basin, Nevada and California. It was compiled from individual county 1:250,000-scale...

  8. 1:250,000-scale geology of the Dry Valley Hydrographic Area, Nevada and California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This dataset consists of digital geologic data for the Dry Valley Hydrographic area, Nevada and California. It was compiled from individual 1:250,000-scale geologic...

  9. MODIS/Aqua Calibrated Radiances 5-Min L1B Swath 250m V005

    Data.gov (United States)

    National Aeronautics and Space Administration — MODIS image data for bands 1 and 2 at 250m (Nadir) resolution, calibrated from raw counts into physically meaningful radiances and reflectances. Corrections for...

  10. 30 CFR 250.407 - What tests must I conduct to determine reservoir characteristics?

    Science.gov (United States)

    2010-07-01

    ... OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations General Requirements § 250.407 What tests must I conduct to determine...

  11. 30 CFR 250.412 - What requirements must the location plat meet?

    Science.gov (United States)

    2010-07-01

    ... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.412 What requirements must the location plat meet? The location plat...

  12. 30 CFR 250.460 - What are the requirements for conducting a well test?

    Science.gov (United States)

    2010-07-01

    ... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Other Drilling Requirements § 250.460 What are the requirements for conducting a well test? (a) If you...

  13. MODIS/Terra Surface Reflectance Daily L2G Global 250m SIN Grid V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The MOD09GQ Version 6 product provides an estimate of the surface spectral reflectance of Terra MODIS 250 m bands 1-2 corrected for atmospheric conditions such as...

  14. Bioavailability study of calcium sandoz-250 by atomic absorption spectroscopy in albino rats.

    Science.gov (United States)

    Patel, Bimalkumar N; Krishnaveni, N; Jivani, Nurrrudin P; Khodakiya, Akruti S; Khodakiya, Moorti S; Parida, Saswat K

    2014-01-01

    Calcium sandoz-250 is an Ayurvedic calcium supplement, containing Khatika Churna. Bioavailability study of the formulation is essential for estimation of peak plasma concentration (C max), time to C max and rate of absorption. To evaluate the absorption parameters of calcium sandoz-250 in albino rats by atomic absorption spectroscopic (AAS) method. Study was carried out as a single dose, open-label, randomized study. Estimation of calcium was carried out by AAS, after validating the method for a few parameters for the estimation. Pharmacokinetic parameters such as C max, time to peak concentration (T max), area under the plasma concentration - time curve were calculated for calcium on administration of calcium sandoz-250. Linearity curve was plotted for 0.5-2.5 ppm, given R (2) value 0.9975. The C max, i.e. C max after administration of calcium sandoz-250 was 0.793 mg/ml at 90 min (T max). Measurable calcium-blood levels were noticed in all subjects up to 3.0 h after administration of calcium sandoz-250. Calcium sandoz-250, consisting of Khatika Churna, increases the blood calcium level in albino rats.

  15. Transmission of the P250R mutation of the FGFR3 gene in four generations with highly variable phenotype

    DEFF Research Database (Denmark)

    Hove, Hanne Buciek; Dunø, Morten; Daugaard-Jensen, Jette

    Transmission of the P250R mutation of the FGFR3 gene in four generations with highly variable phenotype.......Transmission of the P250R mutation of the FGFR3 gene in four generations with highly variable phenotype....

  16. 17 CFR 250.12 - Exemption of certain public utility companies from the definition of subsidiary companies of...

    Science.gov (United States)

    2010-04-01

    ... utility companies from the definition of subsidiary companies of holding companies. 250.12 Section 250.12... REGULATIONS, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 Registration and General Exemptions § 250.12 Exemption of certain public utility companies from the definition of subsidiary companies of holding companies...

  17. 30 CFR 250.1163 - How must I measure gas flaring or venting volumes and liquid hydrocarbon burning volumes, and...

    Science.gov (United States)

    2010-07-01

    ... volumes and liquid hydrocarbon burning volumes, and what records must I maintain? 250.1163 Section 250..., and Burning Hydrocarbons § 250.1163 How must I measure gas flaring or venting volumes and liquid hydrocarbon burning volumes, and what records must I maintain? (a) If your facility processes more than an...

  18. 30 CFR 250.260 - What Coastal Zone Management Act (CZMA) information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What Coastal Zone Management Act (CZMA) information must accompany the DPP or DOCD? 250.260 Section 250.260 Mineral Resources MINERALS MANAGEMENT... Operations Coordination Documents (docd) § 250.260 What Coastal Zone Management Act (CZMA) information must...

  19. 30 CFR 250.107 - What must I do to protect health, safety, property, and the environment?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I do to protect health, safety, property, and the environment? 250.107 Section 250.107 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General Performance Standards § 250.107 What must ...

  20. 30 CFR 250.417 - What must I provide if I plan to use a mobile offshore drilling unit (MODU)?

    Science.gov (United States)

    2010-07-01

    ... Gas Drilling Operations Applying for A Permit to Drill § 250.417 What must I provide if I plan to use... environment. Actions must include the suspension, curtailment, or modification of drilling or rig operations... offshore drilling unit (MODU)? 250.417 Section 250.417 Mineral Resources MINERALS MANAGEMENT SERVICE...

  1. 17 CFR 250.47 - Exemption of public utility subsidiaries as to certain securities issued to the Rural...

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exemption of public utility subsidiaries as to certain securities issued to the Rural Electrification Administration. 250.47 Section 250.47... Transactions 2 § 250.47 Exemption of public utility subsidiaries as to certain securities issued to the Rural...

  2. MEET ISOLDE - Target Production

    CERN Multimedia

    2017-01-01

    MEET ISOLDE - Target Production. Everything at ISOLDE starts with a target and the target production team realise on more then 50 years of experience to build and develop new targets for ISOLDE’s wide physics program.

  3. Low Cycle Fatigue Behavior of HT250 Gray Cast Iron for Engine Cylinder Blocks

    Science.gov (United States)

    Fan, K. L.; He, G. Q.; She, M.; Liu, X. S.; Yang, Y.; Lu, Q.; shen, Y.; Tian, D. D.

    2014-08-01

    The strain-controlled low cycle fatigue properties were evaluated on specimens of HT250 gray cast iron (GCI) at room temperature. The material exhibited cyclic stabilization at a low strain amplitude of 0.1% and cyclic softening characteristic at higher strain amplitudes (0.15-0.30%). At a representative total strain amplitude (0.30%), the hysteresis loops of HT250 GCI were asymmetric with a large amount of plastic deformation in the compressive phases. Furthermore, the hysteresis loop became larger in both width and height with increasing total strain amplitude (from 0.10 to 0.30%), and tended to exhibit a clockwise rotation. The fatigue crack propagation mechanisms were different at various total strain amplitudes, where high stress concentration due to dislocation pile-up favored fatigue crack initiation in the examined HT250. Finally, the roughness-induced crack closure was a key to determine the crack growth rate as well as fatigue life.

  4. VizieR Online Data Catalog: Draco nebula Herschel 250um map (Miville-Deschenes+, 2017)

    Science.gov (United States)

    Miville-Deschenes, M.-A.; Salome, Q.; Martin, P. G.; Joncas, G.; Blagrave, K.; Dassas, K.; Abergel, A.; Beelen, A.; Boulanger, F.; Lagache, G.; Lockman, F. J.; Marshall, D. J.

    2017-03-01

    Draco was observed with Herschel PACS (110 and 170um) and SPIRE (250, 350 and 500um) as part of the open-time program "First steps toward star formation: unveiling the atomic to molecular transition in the diffuse interstellar medium" (P.I. M-A Miville-Deschenes). A field of 3.85x3.85 was observed in parallel mode. Unfortunately, an error occurred during the acquisition of the PACS data making them unusable. Therefore, the results presented here are solely based on SPIRE data, especially the 250um map that has the highest angular resolution. (2 data files).

  5. 30 CFR 250.110 - What must I include in my welding plan?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I include in my welding plan? 250.110... must I include in my welding plan? You must include all of the following in the Welding Plan that you... qualified personnel weld; (c) Practices and procedures for safe welding that address: (1) Welding in...

  6. 30 CFR 250.111 - Who oversees operations under my welding plan?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Who oversees operations under my welding plan... § 250.111 Who oversees operations under my welding plan? A welding supervisor or a designated person in charge must be thoroughly familiar with your welding plan. This person must ensure that each welder is...

  7. 30 CFR 250.113 - What procedures must I follow when welding?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What procedures must I follow when welding? 250....113 What procedures must I follow when welding? (a) Before you weld, you must move any equipment containing hydrocarbons or other flammable substances at least 35 feet horizontally from the welding area...

  8. 30 CFR 250.457 - What equipment is required to monitor drilling fluids?

    Science.gov (United States)

    2010-07-01

    ... Drilling Fluid Requirements § 250.457 What equipment is required to monitor drilling fluids? Once you establish drilling fluid returns, you must install and maintain the following drilling fluid-system... indicators on the rig floor: (a) Pit level indicator to determine drilling fluid-pit volume gains and losses...

  9. 30 CFR 250.458 - What quantities of drilling fluids are required?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What quantities of drilling fluids are required... Drilling Fluid Requirements § 250.458 What quantities of drilling fluids are required? (a) You must use, maintain, and replenish quantities of drilling fluid and drilling fluid materials at the drill site as...

  10. 30 CFR 250.456 - What safe practices must the drilling fluid program follow?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What safe practices must the drilling fluid... Operations Drilling Fluid Requirements § 250.456 What safe practices must the drilling fluid program follow? Your drilling fluid program must include the following safe practices: (a) Before starting out of the...

  11. 12 CFR 250.403 - Service of member bank and real estate investment company.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Service of member bank and real estate... Glass-Steagall Act § 250.403 Service of member bank and real estate investment company. (a) The Board recently considered two inquiries regarding the question whether proposed real estate investment companies...

  12. 30 CFR 250.514 - Well-control fluids, equipment, and operations.

    Science.gov (United States)

    2010-07-01

    ... equivalent well-control fluid volume shall be calculated and posted near the operator's station. A mechanical... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Well-control fluids, equipment, and operations... Operations § 250.514 Well-control fluids, equipment, and operations. (a) Well-control fluids, equipment, and...

  13. 30 CFR 250.1162 - When may I burn produced liquid hydrocarbons?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When may I burn produced liquid hydrocarbons... Requirements Flaring, Venting, and Burning Hydrocarbons § 250.1162 When may I burn produced liquid hydrocarbons... hydrocarbons. The Regional Supervisor may allow you to burn liquid hydrocarbons if you demonstrate that...

  14. LCD OF AIR INTAKE MANIFOLDS PHASE 2: FORD F250 AIR INTAKE MANIFOLD

    Science.gov (United States)

    The life cycle design methodology was applied to the design analysis of three alternatives for the lower plehum of the air intake manifold for us with a 5.4L F-250 truck engine: a sand cast aluminum, a lost core molded nylon composite, and a vibration welded nylon composite. The ...

  15. 30 CFR 250.1016 - Granting pipeline rights-of-way.

    Science.gov (United States)

    2010-07-01

    ... application and other required information are found to be in compliance with applicable laws and regulations... AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Pipelines and Pipeline Rights-of-Way § 250.1016 Granting pipeline rights-of-way. (a) In considering an application for a right-of-way, the...

  16. 13 CFR 107.250 - Exclusion of stock options issued by Licensee from Management Expenses.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Exclusion of stock options issued... BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Qualifying for an SBIC License Capitalizing An Sbic § 107.250 Exclusion of stock options issued by Licensee from Management Expenses. Stock options...

  17. 30 CFR 250.227 - What environmental impact analysis (EIA) information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What environmental impact analysis (EIA... and Information Contents of Exploration Plans (ep) § 250.227 What environmental impact analysis (EIA... requirements. Your EIA must: (1) Assess the potential environmental impacts of your proposed exploration...

  18. Silver City, NM AZ 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  19. Tularosa, NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  20. Saint Johns, AZ NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  1. Fort Sumner, NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  2. Tucumcari, NM TX 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  3. Gallup, NM AZ 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  4. Roswell, NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  5. Aztec, NM CO 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  6. Carlsbad, NM TX 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  7. Socorro, NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  8. Clifton, AZ NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  9. El Paso, TX NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  10. Clovis, NM TX 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  11. Hobbs, NM TX 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  12. 30 CFR 250.189 - Reporting requirements for incidents requiring immediate notification.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Reporting requirements for incidents requiring... Information and Reporting Requirements § 250.189 Reporting requirements for incidents requiring immediate...) Lease number, OCS area, and block; (e) Platform/facility name and number, or pipeline segment number; (f...

  13. 30 CFR 250.190 - Reporting requirements for incidents requiring written notification.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Reporting requirements for incidents requiring... Information and Reporting Requirements § 250.190 Reporting requirements for incidents requiring written... pipeline segment number; (6) Type of incident or injury; (7) Operation or activity at time of incident (i.e...

  14. 31 CFR 363.250 - May Public Debt waive these regulations?

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false May Public Debt waive these... (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT REGULATIONS GOVERNING SECURITIES HELD IN TREASURYDIRECT Subpart H Miscellaneous § 363.250 May Public Debt waive these regulations...

  15. 47 CFR 10.250 - Notification to existing subscribers of non-participation in CMAS.

    Science.gov (United States)

    2010-10-01

    ... COMMERCIAL MOBILE ALERT SYSTEM Election to Participate in Commercial Mobile Alert System § 10.250... service agreement. (b) For purposes of this section, a CMS provider that elects not to transmit CMAS Alert... Rule 47 CFR 10.240. (c) In the case of prepaid customers, if a mailing address is available, the CMS...

  16. 21 CFR 250.101 - Amphetamine and methamphetamine inhalers regarded as prescription drugs.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Amphetamine and methamphetamine inhalers regarded... DRUGS New Drug or Prescription Status of Specific Drugs § 250.101 Amphetamine and methamphetamine... and the methamphetamine they contain is being used as a substitute for amphetamine tablets...

  17. 30 CFR 250.112 - What standards must my welding equipment meet?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What standards must my welding equipment meet... § 250.112 What standards must my welding equipment meet? Your welding equipment must meet the following requirements: (a) All engine-driven welding equipment must be equipped with spark arrestors and drip pans; (b...

  18. Muusikamaailm. Maailmaesiettekanne Krimmis. Herderi preemiad 2002. Opera Metz 250. Günter Wand 90 / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2002-01-01

    Krimmis leiab aset Alemdar Karamanovi sümfoonia "Täideläinu" maailma esiettekanne. Johann Gottfried Herderi muusikapreemia sai nimekas rumeenia helilooja Aurel Stroe. Opera Metz Prantsusmaal tähistab oma 250ndat aastapäeva mitmete uuslavastustega. Dirigent Günter Wand tähistab 90ndat juubelit

  19. Raton, NM CO 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  20. 7 CFR 250.64 - Food Distribution Program in the Trust Territory of the Pacific Islands.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Food Distribution Program in the Trust Territory of... DISTRIBUTION DONATION OF FOODS FOR USE IN THE UNITED STATES, ITS TERRITORIES AND POSSESSIONS AND AREAS UNDER ITS JURISDICTION Household Programs § 250.64 Food Distribution Program in the Trust Territory of the...

  1. 30 CFR 250.1400 - How does MMS begin the civil penalty process?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How does MMS begin the civil penalty process...) Civil Penalties § 250.1400 How does MMS begin the civil penalty process? This subpart explains MMS's civil penalty procedures whenever a lessee, operator or other person engaged in oil, gas, sulphur or...

  2. 7 CFR 250.14 - Warehousing, distribution and storage of donated foods.

    Science.gov (United States)

    2010-01-01

    .... (iv) All initial data regarding the cost of the current warehousing and distribution system and the... 7 Agriculture 4 2010-01-01 2010-01-01 false Warehousing, distribution and storage of donated foods... General Operating Provisions § 250.14 Warehousing, distribution and storage of donated foods. (a...

  3. 30 CFR 250.1153 - When must I conduct a static bottomhole pressure survey?

    Science.gov (United States)

    2010-07-01

    ... INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Production Requirements Well Tests and Surveys § 250.1153 When must I conduct a static bottomhole pressure survey? (a) You... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When must I conduct a static bottomhole...

  4. 41 CFR 60-250.25 - Health insurance, life insurance and other benefit plans.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Health insurance, life... SEPARATED VETERANS, AND OTHER PROTECTED VETERANS Discrimination Prohibited § 60-250.25 Health insurance, life insurance and other benefit plans. (a) An insurer, hospital, or medical service company, health...

  5. Experimental f″ of As at 170, 200, 250 and 300 K from the Bijvoet ...

    Indian Academy of Sciences (India)

    Unknown

    Experimental f″ of As at 170, 200, 250 and 300 K from the Bijvoet pairs of GaAs. G RAJA SUDHA, K VIMALA DEVI, D ARTHI, S PRASANNA SUBRAMANIAN,. N SRINIVASAN* and R SARAVANAN†. Department of Physics, Thiagarajar College, Madurai 625 009, India. †The Madura College, Madurai 625 011, India.

  6. 30 CFR 250.402 - When and how must I secure a well?

    Science.gov (United States)

    2010-07-01

    ... GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations General Requirements § 250.402 When and how must I secure a well? Whenever you interrupt drilling operations, you must... that may cause you to interrupt drilling operations are: (1) Evacuation of the drilling crew; (2...

  7. 30 CFR 250.199 - Paperwork Reduction Act statements-information collection.

    Science.gov (United States)

    2010-07-01

    ... and Gas and Drilling Operations (1010-0141), including Forms MMS-123, Application for Permit to Drill... the equipment and procedures to be used in drilling operations on the OCS. To ensure that drilling... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General References § 250.199...

  8. 30 CFR 250.461 - What are the requirements for directional and inclination surveys?

    Science.gov (United States)

    2010-07-01

    ... INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Other Drilling Requirements § 250.461 What are the requirements for directional and inclination... exceed 1,000 feet during the normal course of drilling; (2) You must also conduct a directional survey...

  9. 30 CFR 250.413 - What must my description of well drilling design criteria address?

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.413 What must my description of well... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must my description of well drilling...

  10. 30 CFR 250.409 - May I obtain departures from these drilling requirements?

    Science.gov (United States)

    2010-07-01

    ... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations General Requirements § 250.409 May I obtain departures from these drilling requirements? The District... 30 Mineral Resources 2 2010-07-01 2010-07-01 false May I obtain departures from these drilling...

  11. 30 CFR 250.427 - What are the requirements for pressure integrity tests?

    Science.gov (United States)

    2010-07-01

    ... INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Casing and Cementing Requirements § 250.427 What are the requirements for pressure integrity tests... must suspend drilling operations and remedy the situation. ...

  12. 30 CFR 250.420 - What well casing and cementing requirements must I meet?

    Science.gov (United States)

    2010-07-01

    ... INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Casing and Cementing Requirements § 250.420 What well casing and cementing requirements must I... drilling out of the casing or before commencing completion operations. ...

  13. Spin vectors of asteroids 21 Lutetia, 196 Philomela, 250 Bettina, 337 Devosa, and 804 Hispania

    Science.gov (United States)

    Michalowski, Tadeusz

    1992-01-01

    Such parameters as shape, orientation of spin axis, prograde or retrograde rotation are important for understanding the collisional evolution of asteroids since the primordial epochs of solar system history. These parameters remain unknown for most asteroids and poorly constrained for all but a few. This work presents results for five asteroids: 21, 196, 250, 337, and 804.

  14. 20 CFR 411.250 - How will SSA evaluate a PM?

    Science.gov (United States)

    2010-04-01

    ... 411.250 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Use of One or More Program Managers To Assist in Administration of the Ticket to Work Program... determine the PM's final rating. (c) These performance evaluations will be made part of our database on...

  15. 30 CFR 250.289 - What must the Conceptual Plan contain?

    Science.gov (United States)

    2010-07-01

    ... Section 250.289 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND... the general design basis and philosophy that you will use to develop the field. You must include the following information: (a) An overview of the development concept(s); (b) A well location plat; (c) The...

  16. MODIS/Terra Calibrated Radiances 5-Min L1B Swath 250m

    Data.gov (United States)

    National Aeronautics and Space Administration — The 250 meter MODIS Level 1B data set contains calibrated and geolocated at-aperture radiances for 2 discrete bands located in the 0.62 to 0.88 micron region of the...

  17. MODIS/Terra Calibrated Radiances 5-Min L1B Swath 250m V005

    Data.gov (United States)

    National Aeronautics and Space Administration — The 250 meter MODIS Level 1B data set contains calibrated and geolocated at-aperture radiances for 2 discrete bands located in the 0.62 to 0.88 micron region of the...

  18. MODIS/Aqua Calibrated Radiances 5-Min L1B Swath 250m

    Data.gov (United States)

    National Aeronautics and Space Administration — The 250 meter MODIS Level 1B data set contains calibrated and geolocated at-aperture radiances for 2 discrete bands located in the 0.62 to 0.88 micron region of the...

  19. Alkaline electrolysis cell at high temperature and pressure of 250 °C and 42 bar

    DEFF Research Database (Denmark)

    Allebrod, Frank; Chatzichristodoulou, Christodoulos; Mogensen, Mogens Bjerg

    2013-01-01

    A new type of alkaline electrolysis cells with nickel foam based gas diffusion electrodes and KOH (aq) immobilized in mesoporous SrTiO3 has been developed and tested at temperatures and pressures up to 250 °C and 42 bar, respectively. Current densities of 1.0 A cm−2 have been measured at a cell...

  20. MODIS/Terra Calibrated Radiances 5-Min L1B Swath 250m V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The 250 meter MODIS Level 1B data set contains calibrated and geolocated at-aperture radiances for 2 discrete bands located in the 0.62 to 0.88 micron region of the...

  1. 7 CFR 250.66 - Special Supplemental Nutrition Program for Women, Infants and Children.

    Science.gov (United States)

    2010-01-01

    ... ITS JURISDICTION Household Programs § 250.66 Special Supplemental Nutrition Program for Women, Infants... Special Supplemental Nutrition Program for Women, Infants and Children (WIC Program) under part 246 of... 7 Agriculture 4 2010-01-01 2010-01-01 false Special Supplemental Nutrition Program for Women...

  2. 30 CFR 250.416 - What must I include in the diverter and BOP descriptions?

    Science.gov (United States)

    2010-07-01

    ... rams installed in the BOP stack (both surface and subsea stacks) are capable of shearing the drill pipe... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.416 What must I include in the diverter and BOP descriptions? You must...

  3. 50 CFR 216.250 - Specified activity and specified geographical region.

    Science.gov (United States)

    2010-10-01

    ... Weapon Missions in the Gulf of Mexico § 216.250 Specified activity and specified geographical region. (a... within the Eglin Air Force Base Gulf Test and Training Range within the northern Gulf of Mexico. The... truncatus), Atlantic spotted dolphins (Stenella frontalis), dwarf sperm whales (Kogia simus) and pygmy sperm...

  4. 30 CFR 250.614 - Well-control fluids, equipment, and operations.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Well-control fluids, equipment, and operations... Operations § 250.614 Well-control fluids, equipment, and operations. The following requirements apply during all well-workover operations with the tree removed: (a) Well-control fluids, equipment, and operations...

  5. 30 CFR 250.462 - What are the requirements for well-control drills?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the requirements for well-control... Other Drilling Requirements § 250.462 What are the requirements for well-control drills? You must conduct a weekly well-control drill with each drilling crew. Your drill must familiarize the crew with its...

  6. MODIS/Aqua Calibrated Radiances 5-Min L1B Swath 250m - NRT

    Data.gov (United States)

    National Aeronautics and Space Administration — The 250 meter MODIS Level 1B Near Real Time (NRT) data set contains calibrated and geolocated at-aperture radiances for 2 discrete bands located in the 0.62 to 0.88...

  7. MODIS/Aqua Calibrated Radiances 5-Min L1B Swath 250m V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The 250 meter MODIS Level 1B data set contains calibrated and geolocated at-aperture radiances for 2 discrete bands located in the 0.62 to 0.88 micron region of the...

  8. MODIS/Terra Calibrated Radiances 5-Min L1B Swath 250m - NRT

    Data.gov (United States)

    National Aeronautics and Space Administration — The 250 meter MODIS Level 1B Near Real Time (NRT) data set contains calibrated and geolocated at-aperture radiances for 2 discrete bands located in the 0.62 to 0.88...

  9. Las Cruces, NM TX 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  10. Exploring Terrorist Targeting Preferences

    Science.gov (United States)

    2007-01-01

    Israeli embassies, the British and Australian high commissions and commercial complexes housing some 250 Western business interests. For further...hospitals, restaurants, nightclubs, cinema complexes, (and cynically referred to as the “traffic lights of death”), the schematic delineates the extant...been detained for plotting terrorist attacks in pursuit of the international jihadist cause, including Willie Brigette ( Australian , arrested in 2003

  11. Shielding data for 100-250 MeV proton accelerators double differential neutron distributions and attenuation in concrete

    CERN Document Server

    Agosteo, S; Mereghetti, A; Silari, M; Zajacova, Z

    2007-01-01

    Double differential distributions of neutrons produced by 100, 150, 200 and 250 MeV protons stopped in a thick iron target were simulated with the FLUKA Monte Carlo code at four emission angles: forward, 45°, transverse and 135° backwards. The attenuation in ordinary concrete of the dose equivalent due to secondary neutrons, protons, photons and electrons was calculated. Some of the resulting attenuation curves are best fitted by a double-exponential function rather than a single-exponential. The effect of various approximations introduced in the simulations is thoroughly discussed. The contribution to the total ambient dose equivalent from photons and protons is usually limited to a few percent, except in the backward direction where photons contribute more than 10% and up to 35% to the total dose for a shield thickness of 1 – 2 m. Source terms and attenuation lengths are given as a function of energy and emission angle, along with fit to the Monte Carlo data. An extensive comparison is made of values ob...

  12. A gas/liquid chromatographic-mass spectrometric method for the rapid screening of 250 pesticides in aqueous matrices

    Energy Technology Data Exchange (ETDEWEB)

    Chandramouli, B.; Harvan, D.; Brittain, S.; Hass, R. [Eno River Labs, LLC. Durham, NC (United States)

    2004-09-15

    Pesticide residues in food present a potentially serious and significant cause for concern. Many pesticides have been associated with significant health effects to the nervous and endocrine systems and some have been deemed carcinogenic. There are many well-established techniques for pesticide analysis. However, commercial pesticide methods have traditionally only been available for specific pesticide families, such as chlorinated pesticides or herbicides, and at detection limits ranging from 0.05 ppb to 1 ppm in aqueous matrices. Techniques that can quickly screen for the presence/absence of pesticide residues in food matrices are critical in ensuring the safety of food and water. This paper outlines a combined Gas Chromatographic-High Resolution Mass Spectrometric (GC-HRMS) and Liquid Chromatographic Tandem Mass Spectrometric (LC-MS/MS) screening assay for 250 pesticides that was developed for use in water, and soda samples at screening levels ranging from 0.1-5 ppb. The pesticides selected have been identified by the European Union as being of concern and the target of possible legislation. The list encompasses a variety of pesticide classes and compound groupings.

  13. Correlation of the Largest Craters, Stratigraphic Impact Signatures, and Extinction Events Over the Past 250 Myr

    Science.gov (United States)

    Rampino, Michael R.; Caldeira, Ken

    2017-01-01

    The six largest known impact craters of the last 250 Myr (greater than or equal to 70 km in diameter), which are capable of causing significant environmental damage, coincide with four times of recognized extinction events at 36 (with 2 craters), 66, and 145 Myr ago, and possibly with two provisional extinction events at 168 and 215 Myr ago. These impact cratering events are accompanied by layers in the geologic record interpreted as impact ejecta. Chance occurrences of impacts and extinctions can be rejected at confidence levels of 99.96 percent (for 4 impact/extinctions) to 99.99 percent (for 6 impact/extinctions). These results argue that several extinction events over the last 250 Myr may be related to the effects of large-body impacts.

  14. Oh, la physique ! 250 casse-tête pour tester votre sens physique

    CERN Document Server

    Perelman, Yakov

    2000-01-01

    Grâce à 250 petits problèmes choisis dans la vie quotidienne, ce livre permet de mieux comprendre un vaste ensemble de notions de base en physique. Ne vous fiez pas à l'apparente facilité des questions et réfléchissez plutôt deux fois qu'une avant de répondre... C'est un conseil !

  15. Vernier Scan Results from the First RHIC Proton Run at 250 GeV

    CERN Document Server

    Drees, Angelika

    2010-01-01

    Using the Vernier scan or Van der Meer scan technique, where one beam is swept stepwise transversely across the other while measuring the collision rate as a function of beam displacement, the transverse beam profiles, the luminosity and the effective cross section of the detector in question can be measured. This report briefly recalls the vernier scan technique and presents results from the first RHIC polarized proton run at 250GeV per beam in 2009

  16. 78 FR 45521 - Desert Sunlight 250, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Science.gov (United States)

    2013-07-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Desert Sunlight 250, LLC; Supplemental Notice That Initial Market-Based Rate...-referenced proceeding, of Desert Sunlight 250, LLC's application for market-based rate authority, with an...

  17. 21 CFR 250.11 - Thyroid-containing drug preparations intended for treatment of obesity in humans.

    Science.gov (United States)

    2010-04-01

    ... laxatives, are being marketed for or as adjuncts to the treatment, control, or management of obesity in... connection with the treatment, control, or management of obesity in patients having normal thyroid function... treatment of obesity in humans. 250.11 Section 250.11 Food and Drugs FOOD AND DRUG ADMINISTRATION...

  18. 21 CFR 177.1390 - Laminate structures for use at temperatures of 250 °F and above.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Laminate structures for use at temperatures of 250... Laminate structures for use at temperatures of 250 °F and above. (a) The high-temperature laminates identified in this section may be safely used for food contact at temperatures not exceeding 135 °C (275 °F...

  19. 20 CFR 410.250 - Effect of conviction of felonious and intentional homicide on entitlement to benefits.

    Science.gov (United States)

    2010-04-01

    ... intentional homicide on entitlement to benefits. 410.250 Section 410.250 Employees' Benefits SOCIAL SECURITY... conviction of felonious and intentional homicide on entitlement to benefits. An individual who has been finally convicted by a court of competent jurisdiction of the felonious and intentional homicide of a...

  20. 21 CFR 250.12 - Stramonium preparations labeled with directions for use in self-medication regarded as misbranded.

    Science.gov (United States)

    2010-04-01

    ... for use in self-medication regarded as misbranded. 250.12 Section 250.12 Food and Drugs FOOD AND DRUG... for use in self-medication regarded as misbranded. (a) Stramonium products for inhalation have been... ingredients, will be regarded as misbranded if they are labeled with directions for use in self-medication. (2...

  1. 30 CFR 250.192 - What reports and statistics must I submit relating to a hurricane, earthquake, or other natural...

    Science.gov (United States)

    2010-07-01

    ... relating to a hurricane, earthquake, or other natural occurrence? 250.192 Section 250.192 Mineral Resources... statistics must I submit relating to a hurricane, earthquake, or other natural occurrence? (a) You must... tropical storm, or an earthquake. Statistics include facilities and rigs evacuated and the amount of...

  2. Memory timeline: Brain ERP C250 (not P300) is an early biomarker of short-term storage.

    Science.gov (United States)

    Chapman, Robert M; Gardner, Margaret N; Mapstone, Mark; Dupree, Haley M; Antonsdottir, Inga M

    2015-04-16

    Brain event-related potentials (ERPs) offer a quantitative link between neurophysiological activity and cognitive performance. ERPs were measured while young adults performed a task that required storing a relevant stimulus in short-term memory. Using principal components analysis, ERP component C250 (maximum at 250 ms post-stimulus) was extracted from a set of ERPs that were separately averaged for various task conditions, including stimulus relevancy and stimulus sequence within a trial. C250 was more positive in response to task-specific stimuli that were successfully stored in short-term memory. This relationship between C250 and short-term memory storage of a stimulus was confirmed by a memory probe recall test where the behavioral recall of a stimulus was highly correlated with its C250 amplitude. ERP component P300 (and its subcomponents of P3a and P3b, which are commonly thought to represent memory operations) did not show a pattern of activation reflective of storing task-relevant stimuli. C250 precedes the P300, indicating that initial short-term memory storage may occur earlier than previously believed. Additionally, because C250 is so strongly predictive of a stimulus being stored in short-term memory, C250 may provide a strong index of early memory operations. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. 30 CFR 250.807 - Additional requirements for subsurface safety valves and related equipment installed in high...

    Science.gov (United States)

    2010-07-01

    ... valves and related equipment installed in high pressure high temperature (HPHT) environments. 250.807... GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Production Safety Systems § 250... pressure high temperature (HPHT) environments. (a) If you plan to install SSSVs and related equipment in an...

  4. 20 CFR 668.250 - What happens if two or more entities apply for the same area?

    Science.gov (United States)

    2010-04-01

    ... for the same area? 668.250 Section 668.250 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION... for the same area? (a) Every two years, unless there has been a waiver of competition for the area, we... or more entities apply for grants for the same service area, or for overlapping service areas, and a...

  5. 30 CFR 250.108 - What requirements must I follow for cranes and other material-handling equipment?

    Science.gov (United States)

    2010-07-01

    ... other material-handling equipment? 250.108 Section 250.108 Mineral Resources MINERALS MANAGEMENT SERVICE... Petroleum Institute's Recommended Practice for Operation and Maintenance of Offshore Cranes (API RP 2D... for Offshore Pedestal Mounted Cranes (API Spec 2C), incorporated by reference as specified in 30 CFR...

  6. 12 CFR 250.412 - Interlocking relationships between member bank and insurance company-mutual fund complex.

    Science.gov (United States)

    2010-01-01

    ..., annual gross sales receipts of over $1 million. Insurance Company's total gross income for its last... correct, the annual rate of sale might well rise to that level before the end of the first year of... and insurance company-mutual fund complex. 250.412 Section 250.412 Banks and Banking FEDERAL RESERVE...

  7. 75 FR 62919 - Notice of Final Federal Agency Actions on the Route 250 Bypass Interchange at McIntire Road...

    Science.gov (United States)

    2010-10-13

    ... at McIntire Road Project in Virginia AGENCY: Federal Highway Administration (FHWA), DOT. ACTION... the Route 250 Bypass Interchange at McIntire Road project in the City of Charlottesville, Virginia... approvals for the following project in the State of Virginia: Route 250 Bypass Interchange at McIntire Road...

  8. 30 CFR 250.445 - What are the requirements for kelly valves, inside BOPs, and drill-string safety valves?

    Science.gov (United States)

    2010-07-01

    ... motor and use drill pipe instead of a kelly, you must install one kelly valve above, and one strippable kelly valve below, the joint of drill pipe used in place of a kelly; (d) On a top-drive system equipped..., inside BOPs, and drill-string safety valves? 250.445 Section 250.445 Mineral Resources MINERALS...

  9. Alveolar macrophage accumulation rates, for 28 nm and 250 nm PSL, are mediated by separate mechanisms

    Energy Technology Data Exchange (ETDEWEB)

    Moss, O R; Wong, V A, E-mail: moss@thehamner.or [Hamner Institutes for Health Sciences, Research Triangle Park, NC 27509-2137 (United States)

    2009-02-01

    When macrophages accumulate 28 nm and 250 nm diameter polystyrene latex (PSL) beads, the accumulation rates should reflect differences in molecular and cellular function. We used a confocal microscope to measure the accumulation rates of nanoparticles by F344-rat-alveolar macrophages (approx25,000 cells adhered to a 0.7 cm{sup 2} surface). Over the cells were layered 0.1 ml of media, and 0.1 ml of media-with-beads. Fresh cells were introduced for each exposure scenario. The maximum possible individual macrophage exposures were as follows: 8x10{sup 6}, 8x10{sup 5}, and 8x10{sup 4} 28 nm beads per macrophage; and 8x10{sup 4} and 1.12x10{sup 4} 250 nm beads per macrophage. Accumulation rates were estimated over 23 minutes. The increase in bead accumulation-rate matched changes in bead-availability: 7x increase for 250 nm beads; 100x increase for 28 nm beads; and 700x increase for all bead availabilities. The maximum sustained 28 nm bead accumulation rate was > 30,000 /min (for 5 min). Increases in bead accumulation could be explained by two mechanisms: bead-diffusion; and, for the macrophage, macropinocytosis. Also for the highest concentrations of 28 nm beads, we saw a colligative threshold - possibly due to beads masking the cell surface or obstructing cellular mechanisms.

  10. Alveolar macrophage accumulation rates, for 28 nm and 250 nm PSL, are mediated by separate mechanisms

    Science.gov (United States)

    Moss, O. R.; Wong, V. A.

    2009-02-01

    When macrophages accumulate 28 nm and 250 nm diameter polystyrene latex (PSL) beads, the accumulation rates should reflect differences in molecular and cellular function. We used a confocal microscope to measure the accumulation rates of nanoparticles by F344-rat-alveolar macrophages (~25,000 cells adhered to a 0.7 cm2 surface). Over the cells were layered 0.1 ml of media, and 0.1 ml of media-with-beads. Fresh cells were introduced for each exposure scenario. The maximum possible individual macrophage exposures were as follows: 8x106, 8x105, and 8x104 28 nm beads per macrophage; and 8x104 and 1.12x104 250 nm beads per macrophage. Accumulation rates were estimated over 23 minutes. The increase in bead accumulation-rate matched changes in bead-availability: 7x increase for 250 nm beads; 100x increase for 28 nm beads; and 700x increase for all bead availabilities. The maximum sustained 28 nm bead accumulation rate was > 30,000 /min (for 5 min). Increases in bead accumulation could be explained by two mechanisms: bead-diffusion; and, for the macrophage, macropinocytosis. Also for the highest concentrations of 28 nm beads, we saw a colligative threshold -- possibly due to beads masking the cell surface or obstructing cellular mechanisms.

  11. Baerveldt 250 mm2 Glaucoma Drainage Devices in Eyes With Preexisting Scleral Buckles.

    Science.gov (United States)

    Zhang, Linda; Blachley, Taylor S; Weizer, Jennifer S

    2016-03-01

    To evaluate eyes with preexisting scleral buckles (SBs) that underwent placement of a 250 mm Baerveldt glaucoma drainage device (GDD). Records of all patients with a preexisting SB who underwent 250 mm Baerveldt GDD placement at the Kellogg Eye Center between January 1, 2005 and September 30, 2012 were reviewed. Outcome measures included visual acuity (VA), intraocular pressure (IOP), and number of glaucoma medications prescribed. Seventeen eyes of 17 patients were analyzed. Mean follow-up was 23.9 months. Twelve eyes (70.6%) achieved successful control of IOP (IOP reduction procedures, and no devastating complications). Preoperatively, mean IOP was 25.5 mm Hg, mean number of glaucoma medications was 3.5, and mean logMAR VA was 1.1 (Snellen equivalent 20/200). At 1 and 2 years postoperatively, mean IOP was 9.2 and 8.8 mm Hg (Pglaucoma medications was 0.9 and 0.3 (Pdevice (2 eyes, 12%), phthisis (2 eyes, 12%), and hemorrhagic choroidal detachment (1 eye, 6%). In eyes with preexisting SBs, the Baerveldt 250 mm GDD effectively lowers IOP and reduces the number of glaucoma medications. Complications related to conjunctival dehiscence are not uncommon in these eyes with significantly scarred conjunctiva.

  12. A 4 Gbps current-mode transmitter for 12-bit 250 MSPS ADC

    Science.gov (United States)

    Chen, Zhenhai; Yu, Zongguang; Wei, Jinghe; Zhou, Dejin; Su, Xiaobo; Zou, Jiaxuan

    2017-08-01

    A 4 Gbps transmitter for a 12-bit 250 MSPS pipelined ADCs is presented. A low power current mode (CM) output driver with reverse scaling technique is proposed. A high speed, low power combined serializer is implemented to convert 12 bit parallel data into a seria1 data stream. The whole transmitter is used in a 12-bit 250 MSPS pipelined ADC for the digital output buffer and fabricated in 180 nm 1. 8 V 1P5M CMOS technology. Test results show that the transmitter provides an eye height greater than 800 mV for data rates of both 2 Gbps and 4 Gbps, the 12-bit 250 MSPS ADC achieves the SNR of 69.92 dBFS and SFDR of 81.17 dB with 20.1 MHz input at full sampling speed. The ADC with the 4 Gbps transmitter consumes the power consumption of 395 mW, where the power consumption of transmitter is 75 mW. The ADC occupies an area of 2.5× 3.2 {{mm}}2, where the active area of the transmitter block is 0.5× 1.2 {{mm}}2. Project supported by the National Science Foundation of China (No. 61474092) and Key Project of Natural Science of Anhui Provincial Department of Education (No. KJ2017A396).

  13. [Quantitative determination of total urinary protein utilizing the principle of Coomassie Brilliant Blue G250 binding to protein (author's transl)].

    Science.gov (United States)

    Thomas, L; Winckelmann, M; Michaelis, H C; Walb, D

    1981-04-01

    Coomassie Brilliant Blue G250 was used for the determination of total urinary protein and compared with the biuret-procedure. In the Coomassie Brilliant Blue G250-assay 0.10 ml urine are added to 5.0 ml Coomassie Brilliant Blue G250 reagent and the sample is read against the reagent blank. The Coomassie Brilliant Blue G250 method seems to be superior to the biuret-procedure because of better reproducibility, higher sensitivity and simpler handling. The upper limit or urinary protein excretion in 49 healthy subjects was 120 mg/24 h. To evaluate the clinical significance of the Coomassie Brilliant Blue G250 method the urinary protein concentration of 134 patients with metabolic, systemic and organ diseases was compared with the biuret-procedure. The regression line was y = 0.827 X + 8.713 mg/l with a correlation coefficient of r = 0.966. The type of proteinuria (mixed, glomerular, tubular) had no influence on the protein value measured with the Coomassie Brilliant Blue G250 method. However in selective proteinuria, like Bence-Jones protein excretion, there is no correlation between the two methods, because the concentration of Bence-Jones protein is underestimated. Lower protein values were also frequently obtained for patients with diabetes mellitus. Some specimens from patients with chronic renal failure treated by haemodialysis showed elevated values. In spite of these limitations the Coomassie Brilliant Blue G250 method might become the method of choice for the determination of total urinary protein.

  14. Targeted therapies for cancer

    Science.gov (United States)

    ... so they cannot spread. How Does Targeted Therapy Work? Targeted therapy drugs work in a few different ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

  15. Reflectance Reference Targets (OTTER)

    Data.gov (United States)

    National Aeronautics and Space Administration — ABSTRACT: Spectral reflectance measurements of flat field targets as reference points representative of pseudo-invariant targets as measured by Spectron SE590...

  16. Reflectance Reference Targets (OTTER)

    Data.gov (United States)

    National Aeronautics and Space Administration — Spectral reflectance measurements of flat field targets as reference points representative of pseudo-invariant targets as measured by Spectron SE590 spectrophotometer

  17. TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution

    OpenAIRE

    Samuelsen, Camilla O.; Baraznenok, Vera; Khorosjutina, Olga; Spåhr, Henrik; Kieselbach, Thomas; Holmberg, Steen; Gustafsson, Claes M.

    2003-01-01

    In Saccharomyces cerevisiae Mediator, a subgroup of proteins (Srb8, Srb9, Srb10, and Srb11) form a module, which is involved in negative regulation of transcription. Homologues of Srb10 and Srb11 are found in some mammalian Mediator preparations, whereas no clear homologues have been reported for Srb8 and Srb9. Here, we identify a TRAP240/ARC250 homologue in Schizosaccharomyces pombe and demonstrate that this protein, spTrap240, is stably associated with a larger form of Mediator, which...

  18. Dosing of Ertapenem in an Extreme Obesity: A Case Report of 250 kg Patient

    Directory of Open Access Journals (Sweden)

    Jana Lass

    2017-01-01

    Full Text Available Limited available data for dosing in obesity of the medicines used in this case are discussed, with the emphasis on ertapenem. The case illustrates the difficulties in dosing medicines to morbidly overweight patients. The number of such patients is increasing but data on adequate doses of medicines are scarce. We demonstrate that ertapenem 1,5 g i.v. once daily provided adequate drug exposure for susceptible bacteria in a 250 kg patient with normal renal function. The case suggests the usefulness of therapeutic drug monitoring of antibiotics, especially in critically ill patients.

  19. A Dependence Study of $\\Xi^{*0}$ and $\\bar{\\Xi}^{*0}$ in 250 GeV/c $\\pi^-$. $K^-$ -nucleon Interactions

    Energy Technology Data Exchange (ETDEWEB)

    Seixas de Rezende, Fabio Antonio; /Rio de Janeiro, CBPF

    2005-04-01

    A direct measurement of the mass number (A) dependence of the production of the hyperon {Xi}*{sup 0} and its opposite {bar {Xi}}*{sup 0} in {pi}{sup -}, K{sup -} beam-nucleon interactions at 250 GeV/c is reported. The data derive from the experiment E769 at Fermilab. The results were obtained for different targets: Be, Al, Cu and W. It was observed the data are found to be well described by the parametrization {sigma}{sub A} = {sigma}{sub 0}A{sup {alpha}}, {alpha} being calculated for different beams. The results obtained are compared with those results of E769 experiment. The results shown here are preliminary.

  20. Semiclassical analysis of angular differential cross sections for single-electron capture in 250-eV H++H collisions

    Science.gov (United States)

    Frémont, F.

    2015-05-01

    A classical model based on the resolution of Hamilton equations of motion is used to determine the angular distribution of H projectiles following single-electron capture in H++H collisions at an incident projectile energy of 250 eV. At such low energies, the experimental charge-exchange probability and angular differential cross sections exhibit oscillatory structures that are classically related to the number of swaps the electron experiences between the target and the projectile during the collision. These oscillations are well reproduced by models based on quantum mechanics. In the present paper, the angular distribution of H projectiles is determined classically, at angles varying from 0.1° up to 7°. The variation in intensity due to interferences caused by the indiscernibility between different trajectories is calculated, and the role of these interferences is discussed.

  1. Targets for Precision Measurements

    Science.gov (United States)

    Loveland, W.; Yao, L.; Asner, D. M.; Baker, R. G.; Bundgaard, J.; Burgett, E.; Cunningham, M.; Deaven, J.; Duke, D. L.; Greife, U.; Grimes, S.; Heffner, M.; Hill, T.; Isenhower, D.; Klay, J. L.; Kleinrath, V.; Kornilov, N.; Laptev, A. B.; Massey, T. N.; Meharchand, R.; Qu, H.; Ruz, J.; Sangiorgio, S.; Selhan, B.; Snyder, L.; Stave, S.; Tatishvili, G.; Thornton, R. T.; Tovesson, F.; Towell, D.; Towell, R. S.; Watson, S.; Wendt, B.; Wood, L.

    2014-05-01

    The general properties needed in targets (sources) for high precision, high accuracy measurements are reviewed. The application of these principles to the problem of developing targets for the Fission TPC is described. Longer term issues, such as the availability of actinide materials, improved knowledge of energy losses and straggling and the stability of targets during irradiation are also discussed.

  2. Setting Asset Performance Targets

    NARCIS (Netherlands)

    Green, D.; Hodkiewicz, M.; Masschelein, S.; Schoenmaker, R.; Muruvan, S.

    2015-01-01

    Setting targets is a common way for organisations to establish performance expectations. However the validity of targets is challenged when performance is influenced by factors beyond the control of the manager. This project examines the issue of target setting for a single asset performance measure

  3. Benchmark calculations on residue production within the EURISOL DS project; Part I: thin targets

    CERN Document Server

    David, J.C; Boudard, A; Doré, D; Leray, S; Rapp, B; Ridikas, D; Thiollière, N

    Report on benchmark calculations on residue production in thin targets. Calculations were performed using MCNPX 2.5.0 coupled to a selection of reaction models. The results were compared to nuclide production cross-sections measured in GSI in inverse kinematics

  4. Benchmark calculations on residue production within the EURISOL DS project; Part II: thick targets

    CERN Document Server

    David, J.-C; Boudard, A; Doré, D; Leray, S; Rapp, B; Ridikas, D; Thiollière, N

    Benchmark calculations on residue production using MCNPX 2.5.0. Calculations were compared to mass-distribution data for 5 different elements measured at ISOLDE, and to specific activities of 28 radionuclides in different places along the thick target measured in Dubna.

  5. A hierarchical, automated target recognition algorithm for a parallel analog processor

    Science.gov (United States)

    Woodward, Gail; Padgett, Curtis

    1997-01-01

    A hierarchical approach is described for an automated target recognition (ATR) system, VIGILANTE, that uses a massively parallel, analog processor (3DANN). The 3DANN processor is capable of performing 64 concurrent inner products of size 1x4096 every 250 nanoseconds.

  6. Automated absolute activation analysis with californium-252 sources

    Energy Technology Data Exchange (ETDEWEB)

    MacMurdo, K.W.; Bowman, W.W.

    1978-09-01

    A 100-mg /sup 252/Cf neutron activation analysis facility is used routinely at the Savannah River Laboratory for multielement analysis of many solid and liquid samples. An absolute analysis technique converts counting data directly to elemental concentration without the use of classical comparative standards and flux monitors. With the totally automated pneumatic sample transfer system, cyclic irradiation-decay-count regimes can be pre-selected for up to 40 samples, and samples can be analyzed with the facility unattended. An automatic data control system starts and stops a high-resolution gamma-ray spectrometer and/or a delayed-neutron detector; the system also stores data and controls output modes. Gamma ray data are reduced by three main programs in the IBM 360/195 computer: the 4096-channel spectrum and pertinent experimental timing, counting, and sample data are stored on magnetic tape; the spectrum is then reduced to a list of significant photopeak energies, integrated areas, and their associated statistical errors; and the third program assigns gamma ray photopeaks to the appropriate neutron activation product(s) by comparing photopeak energies to tabulated gamma ray energies. Photopeak areas are then converted to elemental concentration by using experimental timing and sample data, calculated elemental neutron capture rates, absolute detector efficiencies, and absolute spectroscopic decay data. Calculational procedures have been developed so that fissile material can be analyzed by cyclic neutron activation and delayed-neutron counting procedures. These calculations are based on a 6 half-life group model of delayed neutron emission; calculations include corrections for delayed neutron interference from /sup 17/O. Detection sensitivities of < or = 400 ppB for natural uranium and 8 ppB (< or = 0.5 (nCi/g)) for /sup 239/Pu were demonstrated with 15-g samples at a throughput of up to 140 per day. Over 40 elements can be detected at the sub-ppM level.

  7. Metastable charge-transfer state of californium(iii) compounds.

    Science.gov (United States)

    Liu, Guokui; Cary, Samantha K; Albrecht-Schmitt, Thomas E

    2015-06-28

    Among a series of anomalous physical and chemical properties of Cf(iii) compounds revealed by recent investigations, the present work addresses the characteristics of the optical spectra of An(HDPA)3·H2O (An = Am, Cm, and Cf), especially the broadband photoluminescence from Cf(HDPA)3·H2O induced by ligand-to-metal charge transfer (CT). As a result of strong ion-ligand interactions and the relative ease of reducing Cf(iii) to Cf(ii), a CT transition occurs at low energy (transfer state undergoes radiative and non-radiative relaxations. Broadening of the CT transition arises from strong vibronic coupling and hole-charge interactions in the valence band. The non-radiative relaxation of the metastable CT state results from a competition between phonon-relaxation and thermal tunneling that populates the excited states of Cf(iii).

  8. A multipurpose solid-phase method for protein determination with Coomassie brilliant blue G-250.

    Science.gov (United States)

    Said-Fernández, S; González-Garza, M T; Mata-Cárdenas, B D; Navarro-Marmolejo, L

    1990-11-15

    The multipurpose method for protein determination (MMPD) is based in the Coomassie brilliant blue G-250 binding to immobilized and washed proteins in paper filter disks, and the A600 measurement of the eluted protein-dye complexes. The analysis requires 5-microliters samples, put in 7-mm paper filter disks, which can be stored for up to 2 weeks, without sensible changes in their protein content. The A600 is a logarithmic function of the log of bovine serum albumin quantity, between 2.5 and 250 micrograms with two linear segments used as standard curves: one between 2.5 to 20 micrograms and the other between 20 and 80 micrograms. Results with the MMPD were quantitatively comparable with those obtained with the method of Lowry et al., and those reported by other workers, assaying the following material: (i) bovine serum albumin, in doubly distilled water or in presence of several substances that interfere with the current methods; and (ii) total homogenates and their respective trichloroacetic acid-insoluble extracts, which were obtained from several phenol-rich vegetal specimens and complex animal products. The MMPD is proposed as an alternative for protein determination for its versatility and reliability, in both vegetal or animal products, especially when the analysis with traditional methods is made difficult by the presence of natural or added interfering substances and the sample volume is too small to discard them, or when the material must be stored for relatively long periods of time, prior to its processing.

  9. Radiation damage studies on STAR250 CMOS sensor at 300 keV for electron microscopy

    Science.gov (United States)

    Faruqi, A. R.; Henderson, R.; Holmes, J.

    2006-09-01

    There is a pressing need for better electronic detectors to replace film for recording high-resolution images using electron cryomicroscopy. Our previous work has shown that direct electron detection in CMOS sensors is promising in terms of resolution and efficiency at 120 keV [A.R. Faruqi, R. Henderson, M. Prydderch, R. Turchetta, P. Allport, A. Evans, Nucl. Instr. and Meth. 546 (2005) 170], but in addition, the detectors must not be damaged by the electron irradiation. We now present new measurements on the radiation tolerance of a 25 μm pitch CMOS active-pixel sensor, the STAR250, which was designed by FillFactory using radiation-hard technology for space applications. Our tests on the STAR250 aimed to establish the imaging performance at 300 keV following irradiation. The residual contrast, measured on shadow images of a 300 mesh grid, was >80% after corrections for increased dark current, following irradiation with up to 5×10 7 electrons/pixel (equivalent to 80,000 electron/μm 2). A CMOS sensor with this degree of radiation tolerance would survive a year of normal usage for low-dose electron cryomicroscopy, which is a very useful advance.

  10. Radiation damage studies on STAR250 CMOS sensor at 300 keV for electron microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Faruqi, A.R. [MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH (United Kingdom)]. E-mail: arf@mrc-lmb.cam.ac.uk; Henderson, R. [MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH (United Kingdom); Holmes, J. [Sira Technology Ltd., South Hill, Chislehurst, Kent BR7 5EH (United Kingdom)

    2006-09-01

    There is a pressing need for better electronic detectors to replace film for recording high-resolution images using electron cryomicroscopy. Our previous work has shown that direct electron detection in CMOS sensors is promising in terms of resolution and efficiency at 120 keV [A.R. Faruqi, R. Henderson, M. Prydderch, R. Turchetta, P. Allport, A. Evans, Nucl. Instr. and Meth. 546 (2005) 170], but in addition, the detectors must not be damaged by the electron irradiation. We now present new measurements on the radiation tolerance of a 25 {mu}m pitch CMOS active-pixel sensor, the STAR250, which was designed by FillFactory using radiation-hard technology for space applications. Our tests on the STAR250 aimed to establish the imaging performance at 300 keV following irradiation. The residual contrast, measured on shadow images of a 300 mesh grid, was >80% after corrections for increased dark current, following irradiation with up to 5x10{sup 7} electrons/pixel (equivalent to 80,000 electron/{mu}m{sup 2}). A CMOS sensor with this degree of radiation tolerance would survive a year of normal usage for low-dose electron cryomicroscopy, which is a very useful advance.

  11. Estabilidad acelerada de tabletas de levodopa-carbidopa (250-25 mg

    Directory of Open Access Journals (Sweden)

    Mirna Fernández Cervera

    2001-08-01

    Full Text Available Se realizó el estudio de estabilidad acelerada de tabletas de levodopa-carbidopa (250-25 mg con el empleo de un método de cromatografía líquida de alta resolución y se comprobó su especificidad para estos fines. Se analizó la influencia de medios degradantes artificiales sobre los productos activos, además del efecto de la humedad sobre la estabilidad del producto, colocándolo en hidrostatos con humedades controladas. Este medicamento, producción nacional, cumplió con las especificaciones de calidad descritas en la USP 23 y mostró una alta estabilidad térmica.An accelerated stability study of levodopa-carbidopa tablets (250-25 mg was made using high-performance liquid chromatography which specificity for these purposes was proved. The influence of the artificial degrading media on the active products was analyzed and also the effect of humidity on the product´s satbility was examined after placing the tablets into hydrostats under controlled humidity levels. This domestically-made drug met the quality standards described in USP 23 and showed high heat stability.

  12. MODIS/Terra Land Water Mask Derived from MODIS and SRTM L3 Global 250m SIN Grid V005

    Data.gov (United States)

    National Aeronautics and Space Administration — The MODIS 250 m land-water mask (Short Name: MOD44W) is an improvement over the existing MODIS Nadir Bidirectional Reflectance Distribution Function (BRDF)-Adjusted...

  13. MODIS/Terra Near Real Time (NRT) Vegetation Indices Daily Rolling-8-Day L3 Global 250m SIN Grid

    Data.gov (United States)

    National Aeronautics and Space Administration — The MODIS Near Real Time (NRT) level-3 Vegetation Indices Daily Rolling8Day data, MOD13Q4N, are provided everyday at 250-meter spatial resolution as a gridded leve-3...

  14. Development of distributed target

    CERN Document Server

    Yu Hai Jun; Li Qin; Zhou Fu Xin; Shi Jin Shui; Ma Bing; Chen Nan; Jing Xiao Bing

    2002-01-01

    Linear introduction accelerator is expected to generate small diameter X-ray spots with high intensity. The interaction of the electron beam with plasmas generated at the X-ray converter will make the spot on target increase with time and debase the X-ray dose and the imaging resolving power. A distributed target is developed which has about 24 pieces of thin 0.05 mm tantalum films distributed over 1 cm. due to the structure adoption, the distributed target material over a large volume decreases the energy deposition per unit volume and hence reduces the temperature of target surface, then reduces the initial plasma formalizing and its expansion velocity. The comparison and analysis with two kinds of target structures are presented using numerical calculation and experiments, the results show the X-ray dose and normalized angle distribution of the two is basically the same, while the surface of the distributed target is not destroyed like the previous block target

  15. Peripheral target identification performance modulates eye movements.

    Science.gov (United States)

    Kang, Min-Suk; Kim, Sori; Lee, Kyoung-Min

    2017-04-01

    We often shift our eyes to an interesting stimulus, but it is important to inhibit that eye movement in some environments (e.g., a no-look pass in basketball). Here, we investigated participants' ability to inhibit eye movements when they had to process a peripheral target with a requirement to maintain strict fixation. An array of eight letters composed of four characters was briefly presented and a directional cue was centrally presented to indicate the target location. The stimulus onset asynchrony (SOA) between the cue and the stimulus array was chosen from six values, consisting of pre-cue conditions (-400 and -200ms), a simultaneous cue condition (0ms), and post-cue conditions (200, 400, and 800ms). We found the following: 1) participants shifted their eyes toward the cued location even though the stimulus array was absent at the onset of eye movements, but the eye movement amplitude was smaller than the actual location of the target; 2) eye movements occurred approximately 150ms after the onset of stimulus array in the pre-cue conditions and 250ms after cue onset in the simultaneous and post-cue conditions; and 3) eye movement onsets were delayed and their amplitudes were smaller in correct trials than incorrect trials. These results indicate that the inhibitory process controlling eye movements also compete for cognitive resources like other cognitive processes. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. 30 CFR 250.465 - When must I submit an Application for Permit to Modify (APM) or an End of Operations Report to MMS?

    Science.gov (United States)

    2010-07-01

    ... Modify (APM) or an End of Operations Report to MMS? 250.465 Section 250.465 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Modify and Well Records § 250.465...

  17. Inertial Confinement fusion targets

    Science.gov (United States)

    Hendricks, C. D.

    1982-01-01

    Inertial confinement fusion (ICF) targets are made as simple flat discs, as hollow shells or as complicated multilayer structures. Many techniques were devised for producing the targets. Glass and metal shells are made by using drop and bubble techniques. Solid hydrogen shells are also produced by adapting old methods to the solution of modern problems. Some of these techniques, problems, and solutions are discussed. In addition, the applications of many of the techniques to fabrication of ICF targets is presented.

  18. Target Window Reliability

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-02-11

    The target window design implemented and tested in experiments at ANL have performed without failure for the available beam of 6 mm FWHM on a 12 mm diameter target. However, scaling that design to a 25 mm diameter target size for a 12 mm FWHM beam has proven problematic. Combined thermal and mechanical (pressure induced) stresses and strains are too high to maintain the small coolant gaps and provide adequate fatigue lifetime.

  19. The ISOLDE target robots

    CERN Multimedia

    Maximilein Brice

    2002-01-01

    ISOLDE targets need to be changed frequently, around 80 times per year. The high radiation levels do not permit this to be done by human hands and the target changes are effected by 2 industrial robots (picture _01). On the left, in the distance, the front-end of the GPS (General Purpose Separator) is seen, while the HRS (High Resolution Separator) is at the right. Also seen are the doors to the irradiated-target storage.

  20. Targeting the tumor microenvironment

    Energy Technology Data Exchange (ETDEWEB)

    Kenny, P.A.; Lee, G.Y.; Bissell, M.J.

    2006-11-07

    Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have been proposed. The FDA has already approved drugs targeting microenvironmental components such as VEGF and aromatase and many more agents are in the pipeline. In this article, we describe some of the 'druggable' targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions.

  1. Target Assembly Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Target Assembly Facility integrates new armor concepts into actual armored vehicles. Featuring the capability ofmachining and cutting radioactive materials, it...

  2. Three-dimensional magnetic cloak working from d.c. to 250 kHz

    Science.gov (United States)

    Zhu, Jianfei; Jiang, Wei; Liu, Yichao; Yin, Ge; Yuan, Jun; He, Sailing; Ma, Yungui

    2015-11-01

    Invisible cloaking is one of the major outcomes of the metamaterial research, but the practical potential, in particular for high frequencies (for example, microwave to visible light), is fatally challenged by the complex material properties they usually demand. On the other hand, it will be advantageous and also technologically instrumental to design cloaking devices for applications at low frequencies where electromagnetic components are favourably uncoupled. In this work, we vastly develop the bilayer approach to create a three-dimensional magnetic cloak able to work in both static and dynamic fields. Under the quasi-static approximation, we demonstrate a perfect magnetic cloaking device with a large frequency band from 0 to 250 kHz. The practical potential of our device is experimentally verified by using a commercial metal detector, which may lead us to having a real cloaking application where the dynamic magnetic field can be manipulated in desired ways.

  3. Three-dimensional magnetic cloak working from d.c. to 250 kHz.

    Science.gov (United States)

    Zhu, Jianfei; Jiang, Wei; Liu, Yichao; Yin, Ge; Yuan, Jun; He, Sailing; Ma, Yungui

    2015-11-24

    Invisible cloaking is one of the major outcomes of the metamaterial research, but the practical potential, in particular for high frequencies (for example, microwave to visible light), is fatally challenged by the complex material properties they usually demand. On the other hand, it will be advantageous and also technologically instrumental to design cloaking devices for applications at low frequencies where electromagnetic components are favourably uncoupled. In this work, we vastly develop the bilayer approach to create a three-dimensional magnetic cloak able to work in both static and dynamic fields. Under the quasi-static approximation, we demonstrate a perfect magnetic cloaking device with a large frequency band from 0 to 250 kHz. The practical potential of our device is experimentally verified by using a commercial metal detector, which may lead us to having a real cloaking application where the dynamic magnetic field can be manipulated in desired ways.

  4. 250 kA compact linear transformer driver for wire array z-pinch loads

    Directory of Open Access Journals (Sweden)

    S. C. Bott

    2011-05-01

    Full Text Available We present the application of a short rise (∼150  ns 250 kA linear transformer driver (LTD to wire array z-pinch loads for the first time. The generator is a modification of a previous driver in which a new conical power feed provides a low inductance coupling to wire loads. Performance of the new design using both short circuit and plasma loads is presented and discussed. The final design delivers ∼200  kA to a wire array load which is in good agreement with SCREAMER calculations using a simplified representative circuit. Example results demonstrate successful experiments using cylindrical, conical, and inverse wire arrays as well as previously published work on x-pinch loads.

  5. Structure function scaling in a Reλ = 250 turbulent mixing layer

    KAUST Repository

    Attili, Antonio

    2011-12-22

    A highly resolved Direct Numerical Simulation of a spatially developing turbulent mixing layer is presented. In the fully developed region, the flow achieves a turbulent Reynolds number Reλ = 250, high enough for a clear separation between large and dissipative scales, so for the presence of an inertial range. Structure functions have been calculated in the self-similar region using velocity time series and Taylor\\'s frozen turbulence hypothesis. The Extended Self-Similarity (ESS) concept has been employed to evaluate relative scaling exponents. A wide range of scales with scaling exponents and intermittency levels equal to homogeneous isotropic turbulence has been identified. Moreover an additional scaling range exists for larger scales; it is characterized by smaller exponents, similar to the values reported in the literature for flows with strong shear.

  6. Instruction manual for installation, operation, and maintenance of the Q-250 LLNL filter-life tester

    Energy Technology Data Exchange (ETDEWEB)

    Foote, K.L.; da Roza, R.A.

    1990-12-21

    This manual describes the installation, operation, and maintenance of the LLNL, filter-life tester Q-250. This apparatus is designed to determined the gas life of a variety of chemical filters, such as M10-A1, M11, M13-A2, C2, and similar filters. The LLNL filter-life tester can generate isopropymethylphosphonoflouridate (GB) or dimethyl methylphosphonate (DMMP) vapors in air at flow rates of up to 50 1pm. These filters and their specifications are listed in Appendix A. CAUTION: Personnel performing operations with this tester must be completely familiar with the contents of this manual, knowledgeable in system operation, and knowledgeable of materials used in operation of the LLNL filter-life tester.

  7. Laser system generating 250-mJ bunches of 5-GHz repetition rate, 12-ps pulses.

    Science.gov (United States)

    Agnesi, Antonio; Braggio, Caterina; Carrà, Luca; Pirzio, Federico; Lodo, Stefano; Messineo, Giuseppe; Scarpa, Daniele; Tomaselli, Alessandra; Reali, Giancarlo; Vacchi, Carla

    2008-09-29

    We report on a high-energy solid-state laser based on a master-oscillator power-amplifier system seeded by a 5-GHz repetition-rate mode-locked oscillator, aimed at the excitation of the dynamic Casimir effect by optically modulating a microwave resonator. Solid-state amplifiers provide up to 250 mJ at 1064 nm in a 500-ns (macro-)pulse envelope containing 12-ps (micro-)pulses, with a macro/micropulse format and energy resembling that of near-infrared free-electron lasers. Efficient second-harmonic conversion allowed synchronous pumping of an optical parametric oscillator, obtaining up to 40 mJ in the range 750-850 nm.

  8. Trace determination of ethyl methanesulfonate in Viracept 250 mg tablets by gas chromatography-mass spectrometry.

    Science.gov (United States)

    Rebiere, H; Maggio, A-F; Gimeno, P; Levaillant, D; Civade, C; Bonnet, P-A; Tissier, M-H

    2008-02-01

    Ethyl methanesulfonate (EMS) is a potential human mutagenic and carcinogenic compound which has been found by Roche laboratories in nelfinavir mesylate, the active pharmaceutical ingredient of Viracept. In order to verify the quality of the medicinal product, a gas chromatographic method using mass spectrometry detection was developed for the trace analysis of EMS in Viracept 250 mg tablets from Roche laboratories. Combined with suitable sample preparation including a liquid/liquid extraction this method allows the EMS quantification with a reporting limit of 5 ppm. The extract is injected on a gas chromatographic system with a CP624-CB capillary column. Selected Ion Monitoring mode was used for the EMS quantification. Some validation elements of the method are reported. The validation study was performed over a range from 5 ppm to 100 ppm.

  9. Glacial ice and atmospheric forcing on the Mertz Glacier Polynya over the past 250 years.

    Science.gov (United States)

    Campagne, P; Crosta, Xavier; Houssais, M N; Swingedouw, D; Schmidt, S; Martin, A; Devred, E; Capo, S; Marieu, V; Closset, I; Massé, G

    2015-03-24

    The Mertz Glacier Polynya off George V Land, East Antarctica, is a source of Adélie Land Bottom Water, which contributes up to ~25% of the Antarctic Bottom Water. This major polynya is closely linked to the presence of the Mertz Glacier Tongue that traps pack ice upstream. In 2010, the Mertz Glacier calved a massive iceberg, deeply impacting local sea ice conditions and dense shelf water formation. Here we provide the first detailed 250-year long reconstruction of local sea ice and bottom water conditions. Spectral analysis of the data sets reveals large and abrupt changes in sea surface and bottom water conditions with a ~70-year cyclicity, associated with the Mertz Glacier Tongue calving and regrowth dynamics. Geological data and atmospheric reanalysis, however, suggest that sea ice conditions in the polynya were also very sensitive to changes in surface winds in relation to the recent intensification of the Southern Annular Mode.

  10. Evidence for general instability of past climate from a 250-KYR ice-core record

    DEFF Research Database (Denmark)

    Johnsen, Sigfus Johann; Clausen, Henrik Brink; Dahl-Jensen, Dorthe

    1993-01-01

    interglacial seems to have lasted longer than is implied by the deep-sea SPECMAP record4, in agreement with other land-based observations5,6. We suggest that climate instability in the early part of the last interglacial may have delayed the melting of the Saalean ice sheets in America and Eurasia, perhaps...... results1,2 from two ice cores drilled in central Greenland have revealed large, abrupt climate changes of at least regional extent during the late stages of the last glaciation, suggesting that climate in the North Atlantic region is able to reorganize itself rapidly, perhaps even within a few...... decades. Here we present a detailed stable-isotope record for the full length of the Greenland Ice-core Project Summit ice core, extending over the past 250 kyr according to a calculated timescale. We find that climate instability was not confined to the last glaciation, but appears also to have been...

  11. Snow Cover Maps from MODIS Images at 250 m Resolution, Part 2: Validation

    Directory of Open Access Journals (Sweden)

    Marc Zebisch

    2013-03-01

    Full Text Available The performance of a new algorithm for binary snow cover monitoring based on Moderate Resolution Imaging Spectroradiometer (MODIS satellite images at 250 m resolution is validated using snow cover maps (SCA based on Landsat 7 ETM+ images and in situ snow depth measurements from ground stations in selected test sites in Central Europe. The advantages of the proposed algorithm are the improved ground resolution of 250 m and the near real-time availability with respect to the 500 m standard National Aeronautics and Space Administration (NASA MODIS snow products (MOD10 and MYD10. It allows a more accurate snow cover monitoring at a local scale, especially in mountainous areas characterized by large landscape heterogeneity. The near real-time delivery makes the product valuable as input for hydrological models, e.g., for flood forecast. A comparison to sixteen snow cover maps derived from Landsat ETM/ETM+ showed an overall accuracy of 88.1%, which increases to 93.6% in areas outside of forests. A comparison of the SCA derived from the proposed algorithm with standard MODIS products, MYD10 and MOD10, indicates an agreement of around 85.4% with major discrepancies in forested areas. The validation of MODIS snow cover maps with 148 in situ snow depth measurements shows an accuracy ranging from 94% to around 82%, where the lowest accuracies is found in very rugged terrain restricted to in situ stations along north facing slopes, which lie in shadow in winter during the early morning acquisition.

  12. A framework for global terrain classification using 250-m DEMs to predict geohazards

    Science.gov (United States)

    Iwahashi, J.; Matsuoka, M.; Yong, A.

    2016-12-01

    Geomorphology is key for identifying factors that control geohazards induced by landslides, liquefaction, and ground shaking. To systematically identify landforms that affect these hazards, Iwahashi and Pike (2007; IP07) introduced an automated terrain classification scheme using 1-km-scale Shuttle Radar Topography Mission (SRTM) digital elevation models (DEMs). The IP07 classes describe 16 categories of terrain types and were used as a proxy for predicting ground motion amplification (Yong et al., 2012; Seyhan et al., 2014; Stewart et al., 2014; Yong, 2016). These classes, however, were not sufficiently resolved because coarse-scaled SRTM DEMs were the basis for the categories (Yong, 2016). Thus, we develop a new framework consisting of more detailed polygonal global terrain classes to improve estimations of soil-type and material stiffness. We first prepare high resolution 250-m DEMs derived from the 2010 Global Multi-resolution Terrain Elevation Data (GMTED2010). As in IP07, we calculate three geometric signatures (slope, local convexity and surface texture) from the DEMs. We create additional polygons by using the same signatures and multi-resolution segmentation techniques on the GMTED2010. We consider two types of surface texture thresholds in different window sizes (3x3 and 13x13 pixels), in addition to slope and local convexity, to classify pixels within the DEM. Finally, we apply the k-means clustering and thresholding methods to the 250-m DEM and produce more detailed polygonal terrain classes. We compare the new terrain classification maps of Japan and California with geologic, aerial photography, and landslide distribution maps, and visually find good correspondence of key features. To predict ground motion amplification, we apply the Yong (2016) method for estimating VS30. The systematic classification of geomorphology has the potential to provide a better understanding of the susceptibility to geohazards, which is especially vital in populated areas.

  13. Characterization of TAP Ambr 250 disposable bioreactors, as a reliable scale-down model for biologics process development.

    Science.gov (United States)

    Xu, Ping; Clark, Colleen; Ryder, Todd; Sparks, Colleen; Zhou, Jiping; Wang, Michelle; Russell, Reb; Scott, Charo

    2017-03-01

    Demands for development of biological therapies is rapidly increasing, as is the drive to reduce time to patient. In order to speed up development, the disposable Automated Microscale Bioreactor (Ambr 250) system is increasingly gaining interest due to its advantages, including highly automated control, high throughput capacity, and short turnaround time. Traditional early stage upstream process development conducted in 2 - 5 L bench-top bioreactors requires high foot-print, and running cost. The establishment of the Ambr 250 as a scale-down model leads to many benefits in process development. In this study, a comprehensive characterization of mass transfer coefficient (kL a) in the Ambr 250 was conducted to define optimal operational conditions. Scale-down approaches, including dimensionless volumetric flow rate (vvm), power per unit volume (P/V) and kL a have been evaluated using different cell lines. This study demonstrates that the Ambr 250 generated comparable profiles of cell growth and protein production, as seen at 5-L and 1000-L bioreactor scales, when using kL a as a scale-down parameter. In addition to mimicking processes at large scales, the suitability of the Ambr 250 as a tool for clone selection, which is traditionally conducted in bench-top bioreactors, was investigated. Data show that cell growth, productivity, metabolite profiles, and product qualities of material generated using the Ambr 250 were comparable to those from 5-L bioreactors. Therefore, Ambr 250 can be used for clone selection and process development as a replacement for traditional bench-top bioreactors minimizing resource utilization during the early stages of development in the biopharmaceutical industry. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 33:478-489, 2017. © 2017 American Institute of Chemical Engineers.

  14. Target visibility for multiple maneuvering target tracking

    Science.gov (United States)

    Sabordo, Madeleine G.; Aboutanios, Elias

    2015-05-01

    We present a recursion of the probability of target visibility and its applications to analysis of track life and termination in the context of Global Nearest Neighbour (GNN) approach and Probability Hypothesis Density (PHD) filter. In the presence of uncertainties brought about by clutter; decisions to retain a track, terminate it or initialise a new track are based on probability, rather than on distance criterion or estimation error. The visibility concept is introduced into a conventional data-association-oriented multitarget tracker, the GNN; and a random finite set based-tracker, the PHD filter, to take into account instances when targets become invisible or occluded by obstacles. We employ the natural logarithmof the Dynamic Error Spectrum to assess the performance of the trackers with and without probability of visibility incorporated. Simulation results show that the performance of the GNN tracker with visibility concept incorporated is significantly enhanced.

  15. Frozen spin targets

    CERN Document Server

    Parsons, A S L

    1976-01-01

    Describes six projects which use the frozen-spin principle: Helium-3 R.M.S. and longitudinally polarized frozen spin targets at Rutherford Laboratory, and the frozen spin targets at KEK, Saclay and the one used by the CERN-Helsinki collaboration. (7 refs).

  16. Seedling root targets

    Science.gov (United States)

    Diane L. Haase

    2011-01-01

    Roots are critical to seedling performance after outplanting. Although root quality is not as quick and simple to measure as shoot quality, target root characteristics should be included in any seedling quality assessment program. This paper provides a brief review of root characteristics most commonly targeted for operational seedling production. These are: root mass...

  17. Strategic Targeted Advertising

    NARCIS (Netherlands)

    A. Galeotti; J.L. Moraga-Gonzalez (José Luis)

    2003-01-01

    textabstractWe present a strategic game of pricing and targeted-advertising. Firms can simultaneously target price advertisements to different groups of customers, or to the entire market. Pure strategy equilibria do not exist and thus market segmentation cannot occur surely. Equilibria exhibit

  18. Segmented Target Design

    Science.gov (United States)

    Merhi, Abdul Rahman; Frank, Nathan; Gueye, Paul; Thoennessen, Michael; MoNA Collaboration

    2013-10-01

    A proposed segmented target would improve decay energy measurements of neutron-unbound nuclei. Experiments like this have been performed at the National Superconducting Cyclotron Laboratory (NSCL) located at Michigan State University. Many different nuclei are produced in such experiments, some of which immediately decay into a charged particle and neutron. The charged particles are bent by a large magnet and measured by a suite of charged particle detectors. The neutrons are measured by the Modular Neutron Array (MoNA) and Large Multi-Institutional Scintillation Array (LISA). With the current target setup, a nucleus in a neutron-unbound state is produced with a radioactive beam impinged upon a beryllium target. The resolution of these measurements is very dependent on the target thickness since the nuclear interaction point is unknown. In a segmented target using alternating layers of silicon detectors and Be-targets, the Be-target in which the nuclear reaction takes place would be determined. Thus the experimental resolution would improve. This poster will describe the improvement over the current target along with the status of the design. Work supported by Augustana College and the National Science Foundation grant #0969173.

  19. The CNGS target

    CERN Multimedia

    Patrice Loïez

    2005-01-01

    The CERN Neutrinos to Gran Sasso (CNGS) target ‘magazine’ of five target units. Each unit contains a series of 10-cm long graphite rods distributed over a length of 2 m. It is designed to maximize the number of secondary particles produced and hence the number of neutrinos. One unit is used at a time to prevent over heating.

  20. Targeted therapy in lymphoma

    Directory of Open Access Journals (Sweden)

    Cavalli Franco

    2010-11-01

    Full Text Available Abstract Discovery of new treatments for lymphoma that prolong survival and are less toxic than currently available agents represents an urgent unmet need. We now have a better understanding of the molecular pathogenesis of lymphoma, such as aberrant signal transduction pathways, which have led to the discovery and development of targeted therapeutics. The ubiquitin-proteasome and the Akt/mammalian target of rapamycin (mTOR pathways are examples of pathological mechanisms that are being targeted in drug development efforts. Bortezomib (a small molecule protease inhibitor and the mTOR inhibitors temsirolimus, everolimus, and ridaforolimus are some of the targeted therapies currently being studied in the treatment of aggressive, relapsed/refractory lymphoma. This review will discuss the rationale for and summarize the reported findings of initial and ongoing investigations of mTOR inhibitors and other small molecule targeted therapies in the treatment of lymphoma.

  1. Targets and teamwork

    DEFF Research Database (Denmark)

    Skinner, Timothy C; Lange, Karin S; Hoey, Hilary

    2017-01-01

    with less disagreement about recommended targets. Multiple regression analysis indicated that teams reporting higher HbA1c targets and more target disagreement had parents reporting higher treatment targets. This seemed to partially account for center differences in Hb1Ac. Conclusions: The diabetes care....... Research Design and Methods: Children, under the age of 11 with type 1 diabetes and their parents treated at the study centers participated. Clinical, medical, and demographic data were obtained, along with blood sample for centralized assay. Parents and all members of the diabetes care team completed...... questionnaires on treatment targets for hemoglobin A1c (HbA1c) and recommended frequency of blood glucose monitoring. Results: Totally 1113 (53% male) children (mean age 8.0±2.1years) from 18 centers in 17 countries, along with parents and 113 health-care professionals, participated. There were substantial...

  2. Thermal Analysis for the Dense Granular Target of CIADS

    Directory of Open Access Journals (Sweden)

    Kang Chen

    2016-01-01

    Full Text Available For the China Initiative Accelerator Driven System (CIADS, the energy of the protons is 250 MeV, and the current intensity will reach 10 milliamperes. A new concept of a dense granular spallation target is proposed for which the tungsten granules are chosen as the target material. After being bombarded with the accelerated protons from the accelerator, the tungsten granules with high-temperature flow out of the subcritical reactor and the heat is removed by the heat exchanger. One key issue of the target is to remove the 2.5 MW heat deposition safely. Another one is the heat exchange between the target and the subcritical reactor. Based on the model of effective thermal conductivity, a new thermal code is developed in Matlab. The new code is used to calculate the temperature field of the target area near active zone and it is partly verified by commercial CFD code Fluent. The result shows that the peak temperature of the target zone is nearly 740°C and the reactor and the target are proved to be uncoupled in thermal process.

  3. AA antiproton production target

    CERN Multimedia

    CERN PhotoLab

    1979-01-01

    The first version of the antiproton production target was a tungsten rod, 11 cm long and 3 mm in diameter. The rod was embedded in graphite, pressure-seated into an outer casing of stainless steel. At the entrance to the target assembly was a scintillator screen, imprinted with circles every 5 mm in radius, which allowed to precisely aim the 26 GeV high-intensity proton beam from the PS onto the centre of the target rod. The scintillator screen was a 1 mm thick plate of Cr-doped alumina. See also 7903034 and 7905091.

  4. Electron confinement in multi-anode saw tooth silicon drift detectors with an anode pitch of 250 {micro}m

    Energy Technology Data Exchange (ETDEWEB)

    Sonsky, J.; Valk, H.; Huizenga, J.; Hollander, R.W.; Eijk, C.W.E. van; Sarro, P.M. [Delft Univ. of Technology (Netherlands)

    1999-06-01

    Recently it has been experimentally shown that saw tooth shaped p{sup +} strips allows confinement of drifting electrons in the lateral direction. This is achieved by means of potential gutters induced by an appropriate saw tooth design p{sup +} cathodes. The saw tooth period p{sub x} = 500 {micro}m. The final detector is intended to have an anode pitch of 250 {micro}m. The simulation of a saw tooth configuration with p{sub x} = 250 {micro}m, p{sub y} = 200 {micro}m, and {alpha} = 60{degree} showed that potential gutters with a depth of 80 mV will be produced assuming a drift field of 250 V/cm. The authors will give experimental evidence of these shallow charge confining potential gutters.

  5. Concentration of ions Co(II), Ni(II) at the Tokem-250 carboxylic cation exchange for catalysts development

    Science.gov (United States)

    Zharkova, Valentina; Bobkova, Ludmila; Brichkov, Anton; Kozik, Vladimir

    2017-11-01

    Sorption and catalytic properties of the cation exchanger are investigated. It was found that the Tokem-250 has a wide operating range of pH. The value of the effective ionization constant of the functional groups of the cation exchanger (pKa) is 6.59. The Tokem-250 cation exchanger exhibits selectivity to Ni2+ ions to Co2+ (D˜103). This is probably due to the stability of ion-exchange complexes detected by the method of diffuse reflectance electron spectroscopy (ESDD). According to these data, for Co2+ ions, in contrast to Ni2+, tetragonal distortion of octahedral coordination is characteristic, which has a positive effect on the stability of complexes with Co2+. To obtain spherical catalysts on the basis of Tokem-250, cobalt-containing samples of cation exchanger were used. The developed spherical materials have catalytic activity in the reactions of deep and partial oxidation of n-heptane.

  6. Snow Cover Maps from MODIS Images at 250 m Resolution, Part 1: Algorithm Description

    Directory of Open Access Journals (Sweden)

    Claudia Notarnicola

    2013-01-01

    Full Text Available A new algorithm for snow cover monitoring at 250 m resolution based on Moderate Resolution Imaging Spectroradiometer (MODIS images is presented. In contrast to the 500 m resolution MODIS snow products of NASA (MOD10 and MYD10, the main goal was to maintain the resolution as high as possible to allow for a more accurate detection of snow covered area (SCA. This is especially important in mountainous regions characterized by extreme landscape heterogeneity, where maps at a resolution of 500 m could not provide the desired amount of spatial details. Therefore, the algorithm exploits only the 250 m resolution bands of MODIS in the red (B1 and infrared (B2 spectrum, as well as the Normalized Difference Vegetation Index (NDVI for snow detection, while clouds are classified using also bands at 500 m and 1 km resolution. The algorithm is tailored to process MODIS data received in real-time through the EURAC receiving station close to Bolzano, Italy, but also standard MODIS products are supported. It is divided into three steps: first the data is preprocessed, including reprojection, calculation of physical reflectance values and masking of water bodies. In a second step, the actual classification of snow, snow in forested areas, and clouds takes place based on MODIS images both from Terra and Aqua satellites. In the third step, snow cover maps derived from images of both sensors of the same day are combined to reduce cloud coverage in the final SCA product. Four different quality indices are calculated to verify the reliability of input data, snow classification, cloud detection and viewing geometry. Using the data received through their own station, EURAC can provide SCA maps of central Europe to end users in near real-time. Validation of the algorithm is outlined in a companion paper and indicates good performance with accuracies ranging from 94% to around 82% compared to in situ snow depth measurements, and around 93% compared to SCA derived from

  7. Preliminary methodology investigation of mask pattern fidelity for 250-nm design rules

    Science.gov (United States)

    Coleman, Thomas P.; Sauer, Charles A.; Naber, Robert J.; Hamaker, Henry Chris

    1995-07-01

    Techniques have been developed that can quickly and accurately measure corner rounding and contact fill as key indicators of pattern fidelity. Using these techniques, we have examined writing variables for their effect on the lithographic quality of 1.0 micrometers contact. A small contact is perhaps the most demanding figure to achieve, so the results shown can be considered the worst case for 4X radicle manufacturing at 250 nm design rules. A MEBES 4500 was used as the writing tool, using PBS resist on quartz masks. Standard printing methods, single-phase printing (SPP) and multiphase printing (2X MPP) were examined. Results indicate that excellent corner rounding results can be achieved with small address sizes, regardless of the writing strategy or the dose used. As expected, larger spot sizes increase the amount of corner rounding, regardless of the address. As the pattern address is increased, judicious choices of spot size reduce potential pattern fidelity loss when imaging small contracts and other fine features. Multiphase printing is a technique that offers advantages to the user. Its use of offset scan voting (OSV) is a significant factor in reducing placement errors. MPP (2X) has an additional advantage of providing higher dosages. This provides flexibility in resist choices and in the selection of a process window. With 2X MPP, the user has a wide range of addresses and spot sizes that will give excellent results. The dynamic range of operating conditions possible with 2X MPP when writing 1.0 micrometers contacts is a reduced subset of those available using SPP, due to the 2X writing grid (output address). Implementation of 2X MPP has been limited on previous MEBES models due to increased write times of multipass writing. The MEBES 4500 data path supports 2X MPP with write times that approximate SPP. The practical operating envelope of both writing strategies are detailed in this paper. Overall, the MEBES 4500 has a large dynamic operating range. When

  8. Crop Dominance Mapping with IRS-P6 and MODIS 250-m Time Series Data

    Directory of Open Access Journals (Sweden)

    Murali Krishna Gumma

    2014-04-01

    Full Text Available This paper describes an approach to accurately separate out and quantify crop dominance areas in the major command area in the Krishna River Basin. Classification was performed using IRS-P6 (Indian Remote Sensing Satellite, series P6 and MODIS eight-day time series remote sensing images with a spatial resolution of 23.6 m, 250 m for the year 2005. Temporal variations in the NDVI (Normalized Difference Vegetation Index pattern obtained in crop dominance classes enables a demarcation between long duration crops and short duration crops. The NDVI pattern was found to be more consistent in long duration crops than in short duration crops due to the continuity of the water supply. Surface water availability, on the other hand, was dependent on canal water release, which affected the time of crop sowing and growth stages, which was, in turn, reflected in the NDVI pattern. The identified crop-wise classes were tested and verified using ground-truth data and state-level census data. The accuracy assessment was performed based on ground-truth data through the error matrix method, with accuracies from 67% to 100% for individual crop dominance classes, with an overall accuracy of 79% for all classes. The derived major crop land areas were highly correlated with the sub-national statistics with R2 values of 87% at the mandal (sub-district level for 2005–2006. These results suggest that the methods, approaches, algorithms and datasets used in this study are ideal for rapid, accurate and large-scale mapping of paddy rice, as well as for generating their statistics over large areas. This study demonstrates that IRS-P6 23.6-m one-time data fusion with MODIS 250-m time series data is very useful for identifying crop type, the source of irrigation water and, in the case of surface water irrigation, the way in which it is applied. The results from this study have assisted in improving surface water and groundwater irrigated areas of the command area and also

  9. Investigation of Murine Models for Sleep, Wakefulness and Target Discovery

    Science.gov (United States)

    2007-10-01

    subjective day, 7pm-7am w R NR 0 50 100 150 200 250 state c o u n t s F2 Females F2 Males Different from humans, mice exhibit polyphasic sleep with many...early trends, e.g., in the 1p.m. (6 hrs of subjective night) group, became non-significant with additional mice tested • The polyphasic sleep ...REPORT Final report - Investigation of Murine Models for Sleep , Wakefulness and Target Discovery 14. ABSTRACT 16. SECURITY CLASSIFICATION OF

  10. Laser-based target tracking using principal component descriptors

    CSIR Research Space (South Africa)

    Burke, Michael G

    2010-11-01

    Full Text Available (b) Target 3 is tracked at a speed of over 6 m/s. −15 −10 −5 0 5 10 15 0 2 4 6 8 10 12 14 16 y (m) x (m ) 194 195 208 211 236 240 241 246 247 249 250 258 259 260 (c) Stationary objects are tracked while the scanner moves.... [2] L. E. Navarro-Serment, C. Mertz, and M. Hebert, “Predictive mover detection and tracking in cluttered environments,” in Proc. of the 25th. Army Science Conference, November 2006. [3] J. Xavier, M. Pacheco, D. Castro, and A. Ruano, “Fast line...

  11. Corrigendum to "Geant4 validation of neutron production on thick targets bombarded with 120 GeV protons" [Nucl. Instr. Meth. B 358 (2015) 245-250

    Science.gov (United States)

    Sabra, Mohammad S.

    2016-09-01

    In the paper by Mohammad S. Sabra, due to a mixup, wrong calculations for NEPR ratios, normalized to 20 cm-thick copper, for 40 cm and 60 cm-thick copper at 30° for QGSP-BIC, QGSP-BERT, QGSP-INCLXX, and SHIELDING were published in Table 2. The correct values are listed in the revised Table 2 as below.

  12. Evaluation of the MEBES 4500 reticle writer to commercial requirements of 250-nm design rule IC devices

    Science.gov (United States)

    Abboud, Frank E.; Alexander, David W.; Coleman, Thomas P.; Cook, Allen; Gasiorek, Leonard; Naber, Robert J.; Raymond, Frederick; Sauer, Charles A.

    1996-07-01

    The design rule requirements and error budget allocation for maskmaking have made the mask a critical component in the fabrication of 250 nm design rule IC devices. The MEBES 4500 raster-scan reticle writer was designed to meet the mask requirements for pilot production of this generation of devices. In this paper, we will review the IC device and user requirements that drove the design criteria of the MEBES 4500 system. The architecture of the MEBES 4500 system is described and compared to these design criteria. MEBES 4500 perfonnance results during development, manufacture, and installation are also compared to the commercial requirements of 250 nm design rule ICs.

  13. Target Price Accuracy

    Directory of Open Access Journals (Sweden)

    Alexander G. Kerl

    2011-04-01

    Full Text Available This study analyzes the accuracy of forecasted target prices within analysts’ reports. We compute a measure for target price forecast accuracy that evaluates the ability of analysts to exactly forecast the ex-ante (unknown 12-month stock price. Furthermore, we determine factors that explain this accuracy. Target price accuracy is negatively related to analyst-specific optimism and stock-specific risk (measured by volatility and price-to-book ratio. However, target price accuracy is positively related to the level of detail of each report, company size and the reputation of the investment bank. The potential conflicts of interests between an analyst and a covered company do not bias forecast accuracy.

  14. Optimal exploration target zones

    CSIR Research Space (South Africa)

    Debba, Pravesh

    2008-09-01

    Full Text Available This research describes a quantitative methodology for deriving optimal exploration target zones based on a probabilistic mineral prospectivity map. In order to arrive at out objective, we provide a plausible answer to the following question: "Which...

  15. Delays in thick targets

    CERN Document Server

    Bennett, J R J

    2002-01-01

    The delays in the emission of radioactive particles from a thick target bombarded by high-energy protons is discussed in relation to the basic physical processes of diffusion and effusion through the target and ioniser. The delay time, relative to the decay time, is crucial to the efficiency of particle release at the exit of the ioniser. The principles of minimizing the delay times are discussed with reference to a mathematical model of the process, and some experimental examples are given.

  16. An ISOLDE target unit

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    A good dozen different targets are available for ISOLDE, made of different materials and equipped with different kinds of ion-sources, according to the needs of the experiments. Each separator (GPS: general purpose; HRS: high resolution) has its own target. Because of the high radiation levels, robots effect the target changes, about 80 times per year. In the standard unit shown in picture _01, the target is the cylindrical object in the front. It contains uranium-carbide kept at a temperature of 2200 deg C, necessary for the isotopes to be able to escape. At either end, one sees the heater current leads, carrying 700 A. The Booster beam, some 3E13 protons per pulse, enters the target from left. The evaporated isotope atoms enter a hot-plasma ion source (the black object behind the target). The whole unit sits at 60 kV potential (pulsed in synchronism with the arrival of the Booster beam) which accelerates the ions (away from the viewer) towards one of the 2 separators.

  17. Mapping irrigated lands at 250-m scale by merging MODIS data and National Agricultural Statistics

    Science.gov (United States)

    Pervez, Md Shahriar; Brown, Jesslyn F.

    2010-01-01

    Accurate geospatial information on the extent of irrigated land improves our understanding of agricultural water use, local land surface processes, conservation or depletion of water resources, and components of the hydrologic budget. We have developed a method in a geospatial modeling framework that assimilates irrigation statistics with remotely sensed parameters describing vegetation growth conditions in areas with agricultural land cover to spatially identify irrigated lands at 250-m cell size across the conterminous United States for 2002. The geospatial model result, known as the Moderate Resolution Imaging Spectroradiometer (MODIS) Irrigated Agriculture Dataset (MIrAD-US), identified irrigated lands with reasonable accuracy in California and semiarid Great Plains states with overall accuracies of 92% and 75% and kappa statistics of 0.75 and 0.51, respectively. A quantitative accuracy assessment of MIrAD-US for the eastern region has not yet been conducted, and qualitative assessment shows that model improvements are needed for the humid eastern regions where the distinction in annual peak NDVI between irrigated and non-irrigated crops is minimal and county sizes are relatively small. This modeling approach enables consistent mapping of irrigated lands based upon USDA irrigation statistics and should lead to better understanding of spatial trends in irrigated lands across the conterminous United States. An improved version of the model with revised datasets is planned and will employ 2007 USDA irrigation statistics.

  18. Anatomic variations of the hepatic arteries in 250 patients studied with 64-row CT angiography

    Energy Technology Data Exchange (ETDEWEB)

    Cecco, Carlo Nicola de [University of Rome Sapienza, Polo Pontino, Department of Radiological Sciences, Latina (Italy); University of Rome Sapienza, St. Andrea Hospital, Department of Radiology, Rome (Italy); Ferrari, Riccardo; Rengo, Marco; Paolantonio, Pasquale; Vecchietti, Fabrizio; Laghi, Andrea [University of Rome Sapienza, Polo Pontino, Department of Radiological Sciences, Latina (Italy)

    2009-11-15

    The aim of our study was to determine the frequency of different hepatic arterial variants identified on abdominal CT angiography (CTA) with a 64-row CT system and a high resolution protocol. A total of 250 consecutive abdominal CTAs performed on a 64-row CT system were evaluated. Two radiologists in consensus analyzed arterial phase images; the anatomical findings were grouped according to Michels' classification. An anomalous arterial pattern was observed in 34% of the cases. The most common anomaly was Michels type III (9.2%), followed by types II and V (5.2%), type VI (4.0%), types IV, VII, and IX (2.0%), and type VIII (0.6%). No cases of type X were detected. Unclassified variations were observed in 3.3% of the cases. The new generation of 64-row MDCT allows optimal visualization of splanchnic vascular anomalies with a minimally invasive examination. This visualization is extended to those vessels with a small caliber and slow flow resulting in difficult recognition by classic angiographic studies. The knowledge of anomalous arterial patterns could be very useful in the preoperative planning of surgical and interventional liver procedures. (orig.)

  19. Report on acoustic and vibration measurements on 250 MVA transformer at St. Vital Station, Winnipeg, Manitoba

    Energy Technology Data Exchange (ETDEWEB)

    Weissman, K. [QuietPower Systems, Inc., New York, NE (United States); McLoughlin, M. [Noise Cancellation Technologies, Inc., Linthicum, MD (United States); Schott, R. [Western Canada Testing, Inc., Portage Laprairie, MB (Canada); Tennese, G. [Manitoba Hydro, Winnipeg, MB (Canada); Daneryd, A. [SECRC ABB Corporate Research, Vasteras (Sweden)

    1998-09-01

    Vibroacoustic behaviour of a power transformer was characterized prior to employing active noise control (ANC) to control transformer noise. The effect of changes in temperature and loading conditions on the vibration pattern of the transformer tank received particular attention. The transformer quieting technology has been developed and implemented by QuietPower Systems of New York and Noise Cancellation Technologies Inc., of Maryland. Results of the study will be used to ensure that actuator placement is appropriate for each of the seasons experienced throughout the year, as well as to build boundary element and finite element models of the tank vibration and the associated radiated noise. Boundary element results show that the first four harmonics are the primary contributors to radiated noise. The finite element model used to examine the modal response of the tank structure showed high modal densities, even around the lower order harmonics (120 Hz). This can be interpreted to mean that statistical techniques normally associated with high frequency noise problems may be applicable here because of the high modal density. Results of the completed summer and winter measurements permit an evaluation of the effects of loading conditions, temperature and other environmental factors on transformer noise. Appendix B contains the results of numerical simulations on a 250 MVA transformer. 3 refs., 72 figs., 2 appendices.

  20. Neanderthal Use of Fish, Mammals, Birds, Starchy Plants and Wood 125-250,000 Years Ago

    Science.gov (United States)

    Hardy, Bruce L.; Moncel, Marie-Hélène

    2011-01-01

    Neanderthals are most often portrayed as big game hunters who derived the vast majority of their diet from large terrestrial herbivores while birds, fish and plants are seen as relatively unimportant or beyond the capabilities of Neanderthals. Although evidence for exploitation of other resources (small mammals, birds, fish, shellfish, and plants) has been found at certain Neanderthal sites, these are typically dismissed as unusual exceptions. The general view suggests that Neanderthal diet may broaden with time, but that this only occurs sometime after 50,000 years ago. We present evidence, in the form of lithic residue and use-wear analyses, for an example of a broad-based subsistence for Neanderthals at the site of Payre, Ardèche, France (beginning of MIS 5/end of MIS 6 to beginning of MIS 7/end of MIS 8; approximately 125–250,000 years ago). In addition to large terrestrial herbivores, Neanderthals at Payre also exploited starchy plants, birds, and fish. These results demonstrate a varied subsistence already in place with early Neanderthals and suggest that our ideas of Neanderthal subsistence are biased by our dependence on the zooarchaeological record and a deep-seated intellectual emphasis on big game hunting. PMID:21887315

  1. MUSE-INGS ON AM1354-250: COLLISIONS, SHOCKS, AND RINGS

    Energy Technology Data Exchange (ETDEWEB)

    Conn, Blair C. [Gemini Observatory, Recinto AURA, Colina El Pino, Casilla 603, La Serena (Chile); Fogarty, L. M. R. [Sydney Institute for Astronomy, School of Physics, The University of Sydney, A28, Sydney, 2006 (Australia); Smith, Rory [Yonsei University, Graduate School of Earth System Sciences-Astronomy-Atmospheric Sciences, Yonsei-ro 50, Seoul 120-749 (Korea, Republic of); Candlish, Graeme N., E-mail: bconn@gemini.edu [Departamento de Astronomía, Universidad de Concepción, Casilla 160-C, Concepción (Chile)

    2016-03-10

    We present Multi Unit Spectroscopic Explorer observations of AM1354-250, confirming its status as a collisional ring galaxy that has recently undergone an interaction, creating its distinctive shape. We analyze the stellar and gaseous emission throughout the galaxy finding direct evidence that the gaseous ring is expanding with a velocity of ∼70 km s{sup −1} and that star formation is occurring primarily in H ii regions associated with the ring. This star formation activity is likely triggered by this interaction. We find evidence for several excitation mechanisms in the gas, including emission consistent with shocked gas in the expanding ring and a region of LINER-like emission in the central core of the galaxy. Evidence of kinematic disturbance in both the stars and gas, possibly also triggered by the interaction, can be seen in all of the velocity maps. The ring galaxy retains a weak spiral structure, strongly suggesting the progenitor galaxy was a massive spiral prior to the collision with its companion an estimated 140 ± 12 Myr ago.

  2. A Star-forming Ring around κ Ori 250 pc from the Sun

    Science.gov (United States)

    Pillitteri, I.; Wolk, S. J.; Megeath, S. T.

    2016-04-01

    X-rays are a powerful probe of activity in early stages of star formation. They allow us to identify young stars even after they have lost the IR signatures of circumstellar disks and provide constraints on their distance. Here, we report on XMM-Newton observations that detect 121 young stellar objects (YSOs) in two fields between L1641 S and κ Ori. These observations extend the Survey of Orion A with XMM and Spitzer (SOXS). The YSOs are contained in a ring of gas and dust apparent at millimeter wavelengths, and in far-IR and near-IR surveys. The X-ray luminosity function of the YSOs detected in the two fields indicates a distance of 250-280 pc, much closer than the Orion A cloud and similar to distance estimates of κ Ori. We propose that the ring is a 5-8 pc diameter shell that has been swept up by κ Ori. This ring contains several groups of stars detected by Spitzer and WISE including one surrounding the Herbig Ae/Be stars V1818 Ori. In this interpretation, the κ Ori ring is one of several shells swept up by massive stars within the Orion Eridanus Superbubble and is unrelated to the southern portion of Orion A/L1641 S.

  3. Neanderthal use of fish, mammals, birds, starchy plants and wood 125-250,000 years ago.

    Directory of Open Access Journals (Sweden)

    Bruce L Hardy

    Full Text Available Neanderthals are most often portrayed as big game hunters who derived the vast majority of their diet from large terrestrial herbivores while birds, fish and plants are seen as relatively unimportant or beyond the capabilities of Neanderthals. Although evidence for exploitation of other resources (small mammals, birds, fish, shellfish, and plants has been found at certain Neanderthal sites, these are typically dismissed as unusual exceptions. The general view suggests that Neanderthal diet may broaden with time, but that this only occurs sometime after 50,000 years ago. We present evidence, in the form of lithic residue and use-wear analyses, for an example of a broad-based subsistence for Neanderthals at the site of Payre, Ardèche, France (beginning of MIS 5/end of MIS 6 to beginning of MIS 7/end of MIS 8; approximately 125-250,000 years ago. In addition to large terrestrial herbivores, Neanderthals at Payre also exploited starchy plants, birds, and fish. These results demonstrate a varied subsistence already in place with early Neanderthals and suggest that our ideas of Neanderthal subsistence are biased by our dependence on the zooarchaeological record and a deep-seated intellectual emphasis on big game hunting.

  4. A 250a speleothem record from Bärenhöhle, Austria: comparison with instrumental data

    Science.gov (United States)

    Luetscher, Marc; Hellstrom, John; Fohlmeister, Jens; Müller, Wolfgang; Spötl, Christoph

    2016-04-01

    Bärenhöhle, a cave at the northern rim of the European Alps, is ideally situated to capture paleo-rainfall patterns associated with the advection of North Atlantic moisture. Stable isotope and trace element data from a modern speleothem reveal a marked seasonal signal reflecting a dynamic system subject to forced convection. We examined the uppermost section of a 280 mm-long stalagmite covering the last 250 a. Age control is provided by petrographic and chemical lamina counts and validated by the atmospheric radiocarbon peak as well as U-series ages. Results show a strongly variable signal both in oxygen isotopes and trace element data suggesting a high sensitivity to variations in the hydrological budget. Here, we explore the significance of a major change in the d18O variability starting around 1810 AD and coinciding with the end of a prolonged low in solar activity. We compared these data with instrumental records and identified a close relationship between our proxy signal and decadal solar cycles. We surmise that solar insolation may control local evapotranspiration and thus the hydrological recharge of the karst aquifer during the summer season. The implications of our model are discussed with respect to local environmental conditions during the Little Ice Age.

  5. Neanderthal use of fish, mammals, birds, starchy plants and wood 125-250,000 years ago.

    Science.gov (United States)

    Hardy, Bruce L; Moncel, Marie-Hélène

    2011-01-01

    Neanderthals are most often portrayed as big game hunters who derived the vast majority of their diet from large terrestrial herbivores while birds, fish and plants are seen as relatively unimportant or beyond the capabilities of Neanderthals. Although evidence for exploitation of other resources (small mammals, birds, fish, shellfish, and plants) has been found at certain Neanderthal sites, these are typically dismissed as unusual exceptions. The general view suggests that Neanderthal diet may broaden with time, but that this only occurs sometime after 50,000 years ago. We present evidence, in the form of lithic residue and use-wear analyses, for an example of a broad-based subsistence for Neanderthals at the site of Payre, Ardèche, France (beginning of MIS 5/end of MIS 6 to beginning of MIS 7/end of MIS 8; approximately 125-250,000 years ago). In addition to large terrestrial herbivores, Neanderthals at Payre also exploited starchy plants, birds, and fish. These results demonstrate a varied subsistence already in place with early Neanderthals and suggest that our ideas of Neanderthal subsistence are biased by our dependence on the zooarchaeological record and a deep-seated intellectual emphasis on big game hunting.

  6. A Unified Cropland Layer at 250-m for global agriculture monitoring

    Science.gov (United States)

    Waldner, François; Fritz, Steffen; Di Gregorio, Antonio; Plotnikov, Dmitry; Bartalev, Sergey; Kussul, Nataliia; Gong, Peng; Thenkabail, Prasad S.; Hazeu, Gerard; Klein, Igor; Löw, Fabian; Miettinen, Jukka; Dadhwal, Vinay Kumar; Lamarche, Céline; Bontemps, Sophie; Defourny, Pierre

    2016-01-01

    Accurate and timely information on the global cropland extent is critical for food security monitoring, water management and earth system modeling. Principally, it allows for analyzing satellite image time-series to assess the crop conditions and permits isolation of the agricultural component to focus on food security and impacts of various climatic scenarios. However, despite its critical importance, accurate information on the spatial extent, cropland mapping with remote sensing imagery remains a major challenge. Following an exhaustive identification and collection of existing land cover maps, a multi-criteria analysis was designed at the country level to evaluate the fitness of a cropland map with regards to four dimensions: its timeliness, its legend, its resolution adequacy and its confidence level. As a result, a Unified Cropland Layer that combines the fittest products into a 250 m global cropland map was assembled. With an evaluated accuracy ranging from 82% to 95%, the Unified Cropland Layer successfully improved the accuracy compared to single global products.

  7. Carbonation of Rock Minerals by Supercritical Carbon Dioxide at 250 degrees C.

    Energy Technology Data Exchange (ETDEWEB)

    Sugama, T.; Ecker, L.; Butcher, T.

    2010-06-01

    Wet powder-samples of five rock minerals, granite, albite, hornblende, diorite, and biotite mica, were exposed in supercritical carbon dioxide (scCO2) for 3 days at 250 C under 17.23 MPa pressure, and then the susceptibility of the various crystalline phases present in these mineral structures to reactions with hot scCO2 was investigated by XRD and FT-IR. The anorthite present in diorite was identified as the most vulnerable phase to carbonation. In contrast, biotite displayed a great resistance, although its phase was transformed hydrothermally to sanidine and quartz. Granite comprised of two phases, anorthoclase-type albite and quartz. The carbonation of former phase led to the formation of amorphous sodium and potassium carbonates coexisting with the clay-like by-products of the carbonation reaction. The reactivity of quartz to scCO2 was minimal, if any. Among these rock minerals, only hornblende formed crystalline carbonation products, such as calcite and magnesite after exposure, reflecting the likelihood of an increase in its volume. Based upon the feldspar ternary diagram, the carbonation rate of various different minerals in the plagioclase feldspar family depended primarily on the amount of anorthite. On the other hand, alkali feldspar minerals involving anorthoclase-type albite and sanidine had a lower reactivity with scCO2, compared with that of plagioclase feldspar minerals.

  8. Conceptual study of a 250 kW planar SOFC system for CHP application

    Science.gov (United States)

    Fontell, E.; Kivisaari, T.; Christiansen, N.; Hansen, J.-B.; Pålsson, J.

    In August 2002, Wärtsilä Corporation and Haldor Topsøe A/S entered into a co-operation agreement to start joint development program within the planar SOFC technology. The development program aims to bring to the market highly efficient, clean and cost competitive fuel cell systems with power outputs above 200 kW for distributed power generation with CHP and for marine applications. In this study, the product concept for a 250 kW natural gas-fuelled atmospheric SOFC plant has been studied. The process has been calculated and optimised for high electrical efficiency. In the calculations, system efficiencies more than 55-85% (electrical co-generation) have been reached. The necessary balance of plant (BoP) components have been identified and the concept for grid connection has been defined. The BoP includes fuel and air supply, anode re-circulation, start-up steam, purge gas, exhaust gas heat recovery, back-up power, power electronics and control system. Based on the analysed system and component information, a conceptual design and cost break down structure for the product have been made. The cost breakdown shows that the stack, system control and power electronics are the major cost factors, while the remaining BoP equipment stands for a minor share of the manufacturing cost. Finally, the feasibility of the SOFC plants has been compared to gas engines.

  9. Isolation of a 250 million-year-old halotolerant bacterium from a primary salt crystal

    Science.gov (United States)

    Vreeland, Russell H.; Rosenzweig, William D.; Powers, Dennis W.

    2000-10-01

    Bacteria have been found associated with a variety of ancient samples, however few studies are generally accepted due to questions about sample quality and contamination. When Cano and Borucki isolated a strain of Bacillus sphaericus from an extinct bee trapped in 25-30 million-year-old amber, careful sample selection and stringent sterilization techniques were the keys to acceptance. Here we report the isolation and growth of a previously unrecognized spore-forming bacterium (Bacillus species, designated 2-9-3) from a brine inclusion within a 250million-year-old salt crystal from the Permian Salado Formation. Complete gene sequences of the 16S ribosomal DNA show that the organism is part of the lineage of Bacillus marismortui and Virgibacillus pantothenticus. Delicate crystal structures and sedimentary features indicate the salt has not recrystallized since formation. Samples were rejected if brine inclusions showed physical signs of possible contamination. Surfaces of salt crystal samples were sterilized with strong alkali and acid before extracting brines from inclusions. Sterilization procedures reduce the probability of contamination to less than 1 in 10 9.

  10. 30 CFR 250.172 - When may the Regional Supervisor grant or direct an SOO or SOP?

    Science.gov (United States)

    2010-07-01

    ... activities pose a threat of serious, irreparable, or immediate harm or damage. This would include a threat to life (including fish and other aquatic life), property, any mineral deposit, or the marine, coastal, or human environment. MMS may require you to do a site-specific study. (See § 250.177(a).) (c) When...

  11. 250 saarlast ja hiidlast ohustab töötajäämine / Toivo Tänavsuu, Vallo Toomet

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2004-01-01

    Saaremaa Laevakompaniis töötavad 250 saarlast ja hiidlast võivad jääda töötuks, sest majandus- ja kommunikatsiooniminister Meelis Atonen ei välista saarte liinidele praamide renti välismaalt koos meeskondadega

  12. 19 CFR 123.7 - Manifest used as an entry for unconditionally free merchandise value not over $250.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Manifest used as an entry for unconditionally free merchandise value not over $250. 123.7 Section 123.7 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS RELATIONS WITH CANADA AND MEXICO General...

  13. Shiprock, AZ NM CO UT 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  14. 40 CFR 1054.250 - What records must I keep and what reports must I send to EPA?

    Science.gov (United States)

    2010-07-01

    ... ENGINES AND EQUIPMENT Certifying Emission Families § 1054.250 What records must I keep and what reports... model year, you must send us a report describing information about engines you produced during the model year as follows: (1) State the total production volume for each engine family that is not subject to...

  15. 40 CFR 1039.250 - What records must I keep and what reports must I send to EPA?

    Science.gov (United States)

    2010-07-01

    ... a report describing the following information about engines you produced during the model year: (1) Report the total number of engines you produced in each engine family by maximum engine power, total...-IGNITION ENGINES Certifying Engine Families § 1039.250 What records must I keep and what reports must I...

  16. 17 CFR 250.53 - Certain registered holding company financings in connection with the acquisition of one or more...

    Science.gov (United States)

    2010-04-01

    ... company shall proceed in good faith, to the extent reasonable under the circumstances, to cause: (A) The... company financings in connection with the acquisition of one or more exempt wholesale generators. 250.53... RULES AND REGULATIONS, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 Regulation and Exemption of Various...

  17. Review and evaluation of sentinel node procedures in 250 melanoma patients with a median follow-up of 6 years

    NARCIS (Netherlands)

    Estourgie, Susanne H.; Nieweg, Omgo E.; Valdés Olmos, Renato A.; Hoefnagel, Cornelis A.; Kroon, Bin B. R.

    2003-01-01

    BACKGROUND: The aim of this study was to evaluate the results of sentinel node biopsy in cutaneous melanoma at our institute. METHODS: A total of 250 patients with cutaneous melanoma were studied prospectively. Preoperative lymphoscintigraphy was performed after injection of (99m)Tc-nanocolloid

  18. The desing and calibration of the AHEAD deuteron polarimeter for 120 < E sub d < 250 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Cameron, J.M.; Ni, B. (Indiana Univ., Bloomington, IN (USA). University Cyclotron Facility); Antonuk, L.E.; Cairns, E.B.; Fielding, H.W.; Holm, L.; Igarashi, R.; Lapointe, C.; McDonald, W.J.; Pasos, J.; Rodning, N.L.; Roy, G.; Soukup, J.; Ziegler, W. (Alberta Univ., Edmonton, AB (Canada). Dept. of Physics); Arvieux, J.; Tinslay, J.; Yonnet, J. (CEN-Saclay, 91 - Gif-sur-Yvette (France). Lab. National Saturne); Bonin, B.; Boudard, A.; Garcon, M. (CEN-Saclay, 91 - Gif-sur-Yvette (France). Service de Physique Nucleaire a Moyenne Energie); Bachelier, D. (Paris-Sud Univ., 91 - Orsay (France). Inst. de Physique Nucleaire); The, I. (Massachusetts Inst. of Tech., Middleton, MA (USA). Bates Linear Accelerator Center)

    1991-07-20

    A new type of deuteron polarimeter to work in the energy range 120 < E{sub d} < 250 MeV has been designed, constructed, and calibrated. The figure of merit ({radical}{epsilon}{Tau}{sub kq}) has been determined for various polarization components from the calibration data. (orig.).

  19. Evaluation of the Performance of Vortex Generators on the DU 91-W2-250 Profile using Stereoscopic PIV

    DEFF Research Database (Denmark)

    Velte, Clara Marika; Hansen, Martin Otto Laver; Meyer, Knud Erik

    2009-01-01

    Stereoscopic PIV measurements investigating the effect of Vortex Generators on the lift force near stall and on glide ratio at best aerodynamic performance have been carried out in the LM Glasfiber wind tunnel on a DU 91-W2-250 profile. Measurements at two Reynolds numbers were analyzed; Re=0...

  20. Evaluation of the Performance of Vortex Generators on the DU 91-W2-250 Profile using Stereoscopic PIV

    DEFF Research Database (Denmark)

    Velte, Clara Marika; Hansen, Martin Otto Laver; Meyer, Knud Erik

    2008-01-01

    Stereoscopic PIV measurements investigating the effect of Vortex Generators on the lift force near stall and on glide ratio at best aerodynamic performance have been carried out in the LM Glasfiber wind tunnel on a DU 91-W2-250 profile. Measurements at two Reynolds numbers were analyzed; Re=0...

  1. 30 CFR 250.451 - What must I do in certain situations involving BOP equipment or systems?

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Blowout Preventer (bop) System Requirements § 250.451 What must I do in... Suspend further drilling operations until that station or pod is operable. (e) Want to drill with a...

  2. 30 CFR 250.432 - How do I obtain a departure to diverter design and installation requirements?

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Diverter System Requirements § 250.432 How do I obtain a departure to diverter... diverter line for floating drilling operations on a dynamically positioned drillship Maintain an...

  3. Heat flow diagrams with and without a deaerator for steam turbine plants with T-250/300-23.5 turbines

    Science.gov (United States)

    Valamin, A. E.; Kultyshev, A. Yu.; Shibaev, T. L.; Gol'dberg, A. A.; Stepanov, M. Yu.

    2016-11-01

    A T-250/300-240 turbine (currently known as T-250/300-23.5), which is operated at 31 steam turbine plants, is the largest in the world extraction turbine (by the heating extraction load) and one of the largest by the nominal capacity. All steam turbine plants equipped with T-250/300-23.5 turbines of different modifications are operated in large cities of Russia and the neighboring countries covering a significant part of the needs of cities for the electric power and almost fully supplying them with heat power. The design life of a significant part of the operated steam turbine plants of this family is either expired or almost expired. It refers to both the turbine unit (including a turbine and a generator) and the turbine plant equipment. For steam turbine plants equipped with T-250/300-23.5 turbines, which were initially designed and mounted for work with deaerators at electric power stations, the heat flow diagrams with and without a deaerator were compared. The main advantages and disadvantages of each scheme were shown. It was concluded that, for the newly constructed power units with supercritical steam parameters, it is preferable to use the heat flow diagram without a deaerator; for the upgraded blocks, if there are no objective reasons for the removal of a deaerator, it is recommended to keep the existing heat flow diagram of a turbine plant.

  4. 30 CFR 250.524 - When am I required to take action from my casing diagnostic test?

    Science.gov (United States)

    2010-07-01

    ... cannot bleed to 0 psig through a 1/2-inch needle valve within 24 hours, or is not bled to 0 psig during a... § 250.521; (e) Any hybrid well with casing or riser pressure exceeding 100 psig; or (f) Any subsea well...

  5. MODIS/Aqua Near Real Time (NRT) Calibrated Radiances 5-Min L1B Swath 250m

    Data.gov (United States)

    National Aeronautics and Space Administration — The 250 meter MODIS Level 1B Near Real Time (NRT) data set contains calibrated and geolocated at-aperture radiances for 2 discrete bands located in the 0.62 to 0.88...

  6. MODIS/Terra Near Real Time (NRT) Calibrated Radiances 5-Min L1B Swath 250m

    Data.gov (United States)

    National Aeronautics and Space Administration — The 250 meter MODIS Level 1B Near Real Time (NRT) data set contains calibrated and geolocated at-aperture radiances for 2 discrete bands located in the 0.62 to 0.88...

  7. 30 CFR 250.214 - What geological and geophysical (G&G) information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What geological and geophysical (G&G... and Information Contents of Exploration Plans (ep) § 250.214 What geological and geophysical (G&G) information must accompany the EP? The following G&G information must accompany your EP: (a) Geological...

  8. 30 CFR 250.244 - What geological and geophysical (G&G) information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What geological and geophysical (G&G... Operations Coordination Documents (docd) § 250.244 What geological and geophysical (G&G) information must accompany the DPP or DOCD? The following G&G information must accompany your DPP or DOCD: (a) Geological...

  9. Burglar Target Selection

    Science.gov (United States)

    Townsley, Michael; Bernasco, Wim; Ruiter, Stijn; Johnson, Shane D.; White, Gentry; Baum, Scott

    2015-01-01

    Objectives: This study builds on research undertaken by Bernasco and Nieuwbeerta and explores the generalizability of a theoretically derived offender target selection model in three cross-national study regions. Methods: Taking a discrete spatial choice approach, we estimate the impact of both environment- and offender-level factors on residential burglary placement in the Netherlands, the United Kingdom, and Australia. Combining cleared burglary data from all study regions in a single statistical model, we make statistical comparisons between environments. Results: In all three study regions, the likelihood an offender selects an area for burglary is positively influenced by proximity to their home, the proportion of easily accessible targets, and the total number of targets available. Furthermore, in two of the three study regions, juvenile offenders under the legal driving age are significantly more influenced by target proximity than adult offenders. Post hoc tests indicate the magnitudes of these impacts vary significantly between study regions. Conclusions: While burglary target selection strategies are consistent with opportunity-based explanations of offending, the impact of environmental context is significant. As such, the approach undertaken in combining observations from multiple study regions may aid criminology scholars in assessing the generalizability of observed findings across multiple environments. PMID:25866418

  10. The Sinuous Target

    Energy Technology Data Exchange (ETDEWEB)

    Zwaska, R. [Fermilab

    2015-06-01

    We report on the concept for a target material comprised of a multitude of interlaced wires of small dimension. This target material concept is primarily directed at high-power neutrino targets where the thermal shock is large due to small beam sizes and short durations; it also has applications to other high-power targets, particularly where the energy deposition is great or a high surface area is preferred. This approach ameliorates the problem of thermal shock by engineering a material with high strength on the micro-scale, but a very low modulus of elasticity on the meso-scale. The low modulus of elasticity is achieved by constructing the material of spring-like wire segments much smaller than the beam dimension. The intrinsic bends of the wires will allow them to absorb the strain of thermal shock with minimal stress. Furthermore, the interlaced nature of the wires provides containment of any segment that might become loose. We will discuss the progress on studies of analogue materials and fabrication techniques for sinuous target materials.

  11. Surface circulation patterns in the Gulf of California derived from MODIS Aqua 250 m

    Science.gov (United States)

    Martínez-Flores, G.; Salinas-González, F.; Gutiérrez de Velasco-Sanromán, G.; Godínez-Orta, L.

    2009-04-01

    The Gulf of California (GC) is a marginal elongated and semi-enclosed sea located at northwest of Mexico, between the Peninsula of Baja California and the mainland Mexico. The considered area average 150 km in width and 1500 km in length, from the mouth of the Colorado River to Cabo Corrientes, Jalisco. It has a maximum depth of 3600 m at the southern inlet and the northern region average 200 m in deep. The study of superficial circulation patterns in the GC is of interest because its relevance to the mechanisms of transport for distribution of a variety of materials -plankton, contaminants, microalgae, etc.- and its association with areas of sedimentary deposits, zones where there is a higher probability for fishing or related to the presence of certain species of marine life. Recent studies explain the circulation of the GC as a result of the Pacific Ocean's forcing, wind, heat fluxes on the sea surface and the interaction between the flow produced by these agents and bathymetry. The objective of this work was to obtain evidence of the patterns of surface circulation using a spatial resolution of 250 m over a period of two to seven days (depending on cloud cover), which offered images from the MODIS Level 1B. This essay is an attempt to contribute with more information to the understanding of the regional dynamics of the GC and its local influence on the zones bordering the coast. Thus, MODIS Aqua 250 m data was used, to which algorithms were applied in order to enhance the contrast of reflectance levels of these bands (0.620-0.670 and 0.841-0.876 µm) within the marine environment. The results are associated with suspended particulate matter (SPM), which we used as tracers of the surface circulation, using a sequence of images from January 2004 to December 2008. Algorithms for dust and cloud detection were used and incorporated with thermal band images, in which zones of terrigenous contribution by eolian transport were identified. Furthermore, pluvial

  12. Evidence of four prehistoric supernovae <250 pc from Earth during the past 50,000 years

    Science.gov (United States)

    Firestone, R. B.

    2009-12-01

    Analysis of the radiocarbon record for the past 50 ka indicates that four supernovae exploded near Earth 44 ka (~110 pc), 37 ka (~180 pc), 32 ka (~160 pc), and 22 ka (250 pc) ago. Each SN left a unique signature in the radiocarbon record consisting of a sudden increase in atmospheric radiocarbon at the time of the initial explosion due to the arrival of γ-rays and neutrinos, followed by a much larger increase in global radiocarbon spanning centuries due to cosmic rays produced by diffusive shock in the SN remnant, and concluding with the decay of the excess global 14C produced in these events. Temporal evolution of this signature is identical for each SN as if it were a “standard candle”. The ~22 ka SN is most likely the Vela SN that is known to have exploded 10-30 ka ago 250 pc from Earth. The distances of the other SNe are calculated from the relative amounts of radiocarbon produced on Earth with respect to the Vela SN assuming a 1/r2 relationship. The rate of these nearby prehistoric SNe is comparable to that expected from the more distant historical SNe observed during the past 1000 years and it is consistent with the galactic cosmic ray rate at Earth. Global radiocarbon doubled after the ~44 ka SN which exploded 110 pc from Earth, a distance consistent with the Upper Scorpius OB Association. It coincides with the advent of modern man, mutations leading to the development of type A and B blood, and major megafaunal extinctions in Southeast Asia. An exponential fit to the past 18 ka of INTCAL04 Δ14C data gives a half-life of 5700±700 yr, consistent with the half-life of 14C (5730 yr), and establishes an absolute scale of Δ14C=5±2% for T=0 in 1950. Small variations about the exponential decay curve correlate with observed changes in the strength of Earth’s virtual axial dipole moment (VADM). Analysis of the energy necessary to produce the excess global radiocarbon indicates that these SNe explosions released ~3x1050 ergs of energy into the production

  13. 200 Jahre Darwin und 250 Jahre Theory of Moral Sentiments von Adam Smith

    Directory of Open Access Journals (Sweden)

    Gerold Bluemle

    2009-06-01

    Full Text Available The author emphasizes that 2009 must be remembered not only for the 200 birthday of Charles Darwin, but as well as the 250-year anniversary of Adam Smith’s “Theory of Moral Sentiments”. Proceeding from the fact that Darwin as well as Robert Malthus refer to a classical economist, it is investigated whether the analogies between Evolution Theory and Economy are justified. In both fields, the competition between the selfishly functioning units plays an important/dominating role. Smith, indeed, stresses in his “Theory of Moral Sentiments” apart from the ‘self-interest’ principle, the meaning of the principle of ‘Sympathy’ as a second in importance one which, as the author indicates, forms a prerequisite for the successful co-operation and harmony that the“invisible hand” establishes. The one-sided meaning of the “Wealth of Nations” as an eulogy of the egoism, that is the only motive, has its cause in the political interest of the rising liberalism. Finally, it is investigated whether Smith’s optimism for a free developing social harmony is justified nowadays, in relation to the rising centra lization and globalization. The author arrives at a conclusion that an economic regulation according to the “Freiburger Schule” views, which will be accomplished by the state and it will correspond with the previous developments, it will be in the position to setmeasures to the consequences of ethic deficit.Der Autor betont, dass 2009 neben dem 200. Geburtstag von Charles Darwin als zweitesJubiläum an das Erscheinen der „Theory of Moral Sentiments“ von Adam Smith vor250 Jahren zu erinnern ist. Ausgehend davon, dass sich Darwin selbst mit RobertMalthus auf einen Klassiker der Ökonomen berief, wird der Frage nachgegangeninwieweit Analogien zwischen der Evolutionstheorie und der Ökonomik gerechtfertigtsind. Bei beiden Ansätzen kommt ja dem Wettbewerb zwischen egoistisch handelndenWesen zentrale Bedeutung zu. Smith indessen

  14. Setting reference targets

    Energy Technology Data Exchange (ETDEWEB)

    Ruland, R.E.

    1997-04-01

    Reference Targets are used to represent virtual quantities like the magnetic axis of a magnet or the definition of a coordinate system. To explain the function of reference targets in the sequence of the alignment process, this paper will first briefly discuss the geometry of the trajectory design space and of the surveying space, then continue with an overview of a typical alignment process. This is followed by a discussion on magnet fiducialization. While the magnetic measurement methods to determine the magnetic centerline are only listed (they will be discussed in detail in a subsequent talk), emphasis is given to the optical/mechanical methods and to the task of transferring the centerline position to reference targets.

  15. Targeted Therapy of CLL.

    Science.gov (United States)

    Al-Sawaf, Othman; Fischer, Kirsten; Eichhorst, Barbara; Hallek, Michael

    2016-01-01

    The landscape of chronic lymphocytic leukemia (CLL) has undergone profound changes in the past years. First, the addition of CD20-targeting antibodies to conventional chemotherapy has improved the therapeutic outcome in the majority of CLL patients. Since the establishment of the critical role of the B cell receptor signaling pathway in the pathogenesis of CLL, several agents have been developed to target this pathway. Ibrutinib and idelalisib, 2 potent kinase inhibitors, have both become available for CLL therapy in the first and second line. Additionally, the observation of high expression levels of the anti-apoptotic mitochondrial protein Bcl-2 in CLL has led to the development of venetoclax, a BH3 mimetic compound that inhibits Bcl-2 and has shown high efficacy in CLL. This short review summarizes preclinical and clinical data on currently available agents in CLL and provides an outlook on upcoming new challenges in the targeted therapy of CLL. © 2016 S. Karger GmbH, Freiburg.

  16. Modelling Recycling Targets

    DEFF Research Database (Denmark)

    Hill, Amanda Louise; Leinikka Dall, Ole; Andersen, Frits M.

    2014-01-01

    Within the European Union (EU) a paradigm shift is currently occurring in the waste sector, where EU waste directives and national waste strategies are placing emphasis on resource efficiency and recycling targets. The most recent Danish resource strategy calculates a national recycling rate of 22......% for household waste, and sets an ambitious goal of a 50% recycling rate by 2020. This study integrates the recycling target into the FRIDA model to project how much waste and from which streams should be diverted from incineration to recycling in order to achieve the target. Furthermore, it discusses how...... the existing technological, organizational and legislative frameworks may affect recycling activities. The results of the analysis show that with current best practice recycling rates, the 50% recycling rate cannot be reached without recycling of household biowaste. It also shows that all Danish municipalities...

  17. Statistics and scaling of turbulence in a spatially developing mixing layer at Reλ = 250

    KAUST Repository

    Attili, Antonio

    2012-03-21

    The turbulent flow originating from the interaction between two parallel streams with different velocities is studied by means of direct numerical simulation. Rather than the more common temporal evolving layer, a spatially evolving configuration, with perturbed laminar inlet conditions is considered. The streamwise evolution and the self-similar state of turbulence statistics are reported and compared to results available in the literature. The characteristics of the transitional region agree with those observed in other simulations and experiments of mixing layers originating from laminar inlets. The present results indicate that the transitional region depends strongly on the inlet flow. Conversely, the self-similar state of turbulent kinetic energy and dissipation agrees quantitatively with those in a temporal mixing layer developing from turbulent initial conditions [M. M. Rogers and R. D. Moser, “Direct simulation of a self-similar turbulent mixing layer,” Phys. Fluids6, 903 (1994)]. The statistical features of turbulence in the self-similar region have been analysed in terms of longitudinal velocity structure functions, and scaling exponents are estimated by applying the extended self-similarity concept. In the small scale range (60 < r/η < 250), the scaling exponents display the universal anomalous scaling observed in homogeneous isotropic turbulence. The hypothesis of isotropy recovery holds in the turbulent mixing layer despite the presence of strong shear and large-scale structures, independently of the means of turbulence generation. At larger scales (r/η > 400), the mean shear and large coherent structures result in a significant deviation from predictions based on homogeneous isotropic turbulence theory. In this second scaling range, the numerical values of the exponents agree quantitatively with those reported for a variety of other flows characterized by strong shear, such as boundary layers, as well as channel and wake flows.

  18. Staining of proteins in gels with Coomassie G-250 without organic solvent and acetic acid.

    Science.gov (United States)

    Lawrence, Ann-Marie; Besir, H Uuml Seyin

    2009-08-14

    In classical protein staining protocols using Coomassie Brilliant Blue (CBB), solutions with high contents of toxic and flammable organic solvents (Methanol, Ethanol or 2-Propanol) and acetic acid are used for fixation, staining and destaining of proteins in a gel after SDS-PAGE. To speed up the procedure, heating the staining solution in the microwave oven for a short time is frequently used. This usually results in evaporation of toxic or hazardous Methanol, Ethanol or 2-Propanol and a strong smell of acetic acid in the lab which should be avoided due to safety considerations. In a protocol originally published in two patent applications by E.M. Wondrak (US2001046709 (A1), US6319720 (B1)), an alternative composition of the staining solution is described in which no organic solvent or acid is used. The CBB is dissolved in bidistilled water (60-80 mg of CBB G-250 per liter) and 35 mM HCl is added as the only other compound in the staining solution. The CBB staining of the gel is done after SDS-PAGE and thorough washing of the gel in bidistilled water. By heating the gel during the washing and staining steps, the process can be finished faster and no toxic or hazardous compounds are evaporating. The staining of proteins occurs already within 1 minute after heating the gel in staining solution and is fully developed after 15-30 min with a slightly blue background that is destained completely by prolonged washing of the stained gel in bidistilled water, without affecting the stained protein bands.

  19. MEBES reticle writers for 350-nm and 250-nm design rules

    Science.gov (United States)

    Abboud, Frank E.; Naber, Robert J.; Dean, Robert L.; Sauer, Charles A.

    1994-11-01

    New MEBES reticle writers are described that meet the production requirements of the 350- nm and 250-nm design rules required for 64 Mb and first generation 256 Mb DRAM techniques. These raster scan e-beam systems are based on the MEBES IV thermal field emission (TFE) exposure system, in production use since early 1992. The MEBES IV-TFE system exceeds its 500-nm design rule requirement and is routinely used to product reticles of first-generation 64 Mb DRAMs, prototype 256 Mb DRAMs, and phase shift masks. The success of MEBES IV-TFE is based on a close working relationship with system users, who provided input to establish the requirements of the new reticle writers. The new reticle writers are the result of a two-phase development program. The initial phase, completed in 1993, focused on productivity improvements to the base system, which proved to have excellent accuracy. These improvements ease the handling of the large pattern files, improve the use of the 160 MHz writing rate with a faster data path and more efficient writing strategy, and improve overall system utilization with in situ (maskless) beam-calibration techniques. The second phase of development, completed early in 1994, focused on the production reticle requirements of second-generation 64 Mb DRAM, including optical proximity correction features, and first-generation 256 Mb DRAM. The second development phase improves data path speed, system accuracy, and system productivity. System and subsystem performance is shown for the first and second development phases. Lithographic and write-time performance on the product is presented and discussed in the context of system requirements.

  20. A 250 plastome phylogeny of the grass family (Poaceae): topological support under different data partitions

    Science.gov (United States)

    Burke, Sean V.; Wysocki, William P.; Clark, Lynn G.

    2018-01-01

    The systematics of grasses has advanced through applications of plastome phylogenomics, although studies have been largely limited to subfamilies or other subgroups of Poaceae. Here we present a plastome phylogenomic analysis of 250 complete plastomes (179 genera) sampled from 44 of the 52 tribes of Poaceae. Plastome sequences were determined from high throughput sequencing libraries and the assemblies represent over 28.7 Mbases of sequence data. Phylogenetic signal was characterized in 14 partitions, including (1) complete plastomes; (2) protein coding regions; (3) noncoding regions; and (4) three loci commonly used in single and multi-gene studies of grasses. Each of the four main partitions was further refined, alternatively including or excluding positively selected codons and also the gaps introduced by the alignment. All 76 protein coding plastome loci were found to be predominantly under purifying selection, but specific codons were found to be under positive selection in 65 loci. The loci that have been widely used in multi-gene phylogenetic studies had among the highest proportions of positively selected codons, suggesting caution in the interpretation of these earlier results. Plastome phylogenomic analyses confirmed the backbone topology for Poaceae with maximum bootstrap support (BP). Among the 14 analyses, 82 clades out of 309 resolved were maximally supported in all trees. Analyses of newly sequenced plastomes were in agreement with current classifications. Five of seven partitions in which alignment gaps were removed retrieved Panicoideae as sister to the remaining PACMAD subfamilies. Alternative topologies were recovered in trees from partitions that included alignment gaps. This suggests that ambiguities in aligning these uncertain regions might introduce a false signal. Resolution of these and other critical branch points in the phylogeny of Poaceae will help to better understand the selective forces that drove the radiation of the BOP and PACMAD

  1. Oversized 250 GHz Traveling Wave Tube with a Photonic Band-Gap Structure

    Science.gov (United States)

    Rosenzweig, Guy; Shapiro, Michael A.; Temkin, Richard J.

    2017-10-01

    The challenge in manufacturing traveling wave tubes (TWTs) at high frequencies is that the sizes of the structures scale with, and are much smaller than, the wavelength. We have designed and are building a 250 GHz TWT that uses an oversized structure to overcome fabrication and power handling issues that result from the small dimensions. Using a photonic band-gap (PBG) structure, we succeeded to design the TWT with a beam tunnel diameter of 0.72 mm. The circuit consists of metal plates with the beam tunnel drilled down their center. Twelve posts are protruding on one side of each plate in a triangular array and corresponding sockets are drilled on the other side. The posts of each plate are inserted into the sockets of an adjacent plate, forming a PBG lattice. The vacuum spacing between adjacent plates forms the `PBG cavity''. The full structure is a series of PBG coupled cavities, with microwave power coupling through the beam tunnel. The PBG lattice provides confinement of microwave power in each of the cavities and can be tuned to give the right amount of diffraction per cavity so that no sever is needed to suppress oscillations in the operating mode. CST PIC simulations predict over 38 dB gain with 67 W peak power, using a 30 kV, 310 mA electron beam, 0.6 mm in diameter. Research supported by the AFOSR Program on Plasma and Electro-Energetic Physics and by the NIH National Institute of Biomedical Imaging and Bioengineering.

  2. [Totally extraperitoneal endoscopic surgery of inguinal hernia: results of 250 hernia repairs].

    Science.gov (United States)

    Zamora-Amorós, Carmen; Calado-Leal, Carlos; Illán-Riquelme, Azahara; Camacho-Lozano, Julio; Ripoll-Martín, Roberto; Diego-Esteve, Manuel

    2012-10-01

    The totally extraperitoneal endoscopic approach in the surgery of the inguinal hernia has experienced an important change, enabling a mesh to be implanted in the pre-peritoneal space with a comfortable access, as well as contributing to the advantages of minimally invasive surgery (less post-operative pain and a faster recovery). The objective of this study is to analyse the results of TEP endoscopic hernioplasty, mainly in the repair of bilateral hernias and recurrences or multiple recurrences. A total of 250 TEP endoscopic hernioplasties have been performed on 150 patients in the las 5 years. The majority (63%) of the patients subjected to surgery had bilateral hernias, and 16%, recurrent. Large and complicated iguinal-scrotal hernias were excluded. A short stay regimen was followed, establishing a protocol of, analgesia, antibiotic, antithrombotic prophylaxis, and collection of post-surgical data such as analgesia demand. The patients were given a questionnaire on discharge, in which they filled in the fields on post-surgical pain, as well as an attached satisfaction questionnaire. The reduced need for post-surgical analgesia was noteworthy in this series, being totally unnecessary at 24h in 70 patients (46.6%), reaching 121 (80.6%) one month after surgery. There were 6 cases (4%) of reconversion, always due to opening of the peritoneal sac. There were no wound infections, 2% mild orchiepididymitis, 6 (2.4%) recurrence, and one (0.4%) inguinal neuralgia. There was a high level of satisfaction (95%). TEP endoscopic hernioplasty is a very effective and safe procedure in the hands of experienced surgeons with specific training. It is an interesting option in bliateral and recurrent hernia as it obtains satisfactory results in terms of postoperative pain and morbidity. Copyright © 2011 AEC. Published by Elsevier Espana. All rights reserved.

  3. Aspectos generales de la Ley número 17.250 de relaciones de consumo

    Directory of Open Access Journals (Sweden)

    Teresita Mercader Pizzorno

    2014-11-01

    Full Text Available El 20 de setiembre de 1999 el Poder Ejecutivo de nuestro país promulgó una ley, la 17.189, por la que se establecían normas destinadas a regular las relaciones de consumo, la que fue publicada en el Diario Oficial del 30 de setiembre de 1999.Su último art., el 52, establecía que comenzaría a regir a los nueve meses contados desde su publicación. Por tanto, la fecha de entrada en vigencia fue ello. de julio del presente año.Sin embargo, un error acaecido en el proceso de elaboración determinó que, en forma prácticamente inmediata a su entrada en vigor, se procediera a elaborar un proyecto de ley para derogarla y sustituirla por otra, que fue promulgada el 11 de agosto de 2000 con el número 17.250 Y fue reglamentada por decreto 244/2000 del 23 de agosto del mismo año.El texto de la nueva leyes prácticamente igual al de la anterior, excepto, claro está, el artículo 33 que es el que había sido aprobado en el trámite de sanción en una y otra Cámara con distinto texto,También en la segunda ley se sustituyó el artículo 52 antes citado (...

  4. A role for the septation initiation network in septum assembly revealed by genetic analysis of sid2-250 suppressors.

    Science.gov (United States)

    Jin, Quan-Wen; Zhou, Mian; Bimbo, Andrea; Balasubramanian, Mohan K; McCollum, Dannel

    2006-04-01

    In the fission yeast Schizosaccharomyces pombe the septation initiation network (SIN) is required for stabilization of the actomyosin ring in late mitosis as well as for ring constriction and septum deposition. In a genetic screen for suppressors of the SIN mutant sid2-250, we isolated a mutation, ace2-35, in the transcription factor Ace2p. Both ace2Delta and ace2-35 show defects in cell separation, and both can rescue the growth defects of some SIN mutants at low restrictive temperatures, where the SIN single mutants lyse at the time of cytokinesis. By detailed analysis of the formation and constriction of the actomyosin ring and septum in the sid2-250 mutant at low restrictive temperatures, we show that the lysis phenotype of the sid2-250 mutant is likely due to a weak cell wall and septum combined with enzymatic activity of septum-degrading enzymes. Consistent with the recent findings that Ace2p controls transcription of genes involved in cell separation, we show that disruption of some of these genes can also rescue sid2-250 mutants. Consistent with SIN mutants having defects in septum formation, many SIN mutants can be rescued at the low restrictive temperature by the osmotic stabilizer sorbitol. The small GTPase Rho1 is known to promote cell wall formation, and we find that Rho1p expressed from a multi-copy plasmid can also rescue sid2-250 at the low restrictive temperature. Together these results suggest that the SIN has a role in promoting proper cell wall formation at the division septa.

  5. Optimal exploration target zones

    CSIR Research Space (South Africa)

    Debba, Pravesh

    2008-09-01

    Full Text Available , Carranza, Stein, van der Meer Introduction to Remote Sensing Background and Objective of the study Methodology Results Optimal Exploration Target Zones Pravesh Debba1, Emmanual M.J. Carranza2, Alfred Stein2, Freek D. van der Meer2 1CSIR, Logistics... and Quantitative Methods, CSIR Built Environment 2International Institute for Geo-Information Science and Earth Observation (ITC), Hengelosestraat 99, P.O. Box 6, 7500AA Enschede, The Netherlands Optimal Exploration Target Zones Debba, Carranza, Stein, van der Meer...

  6. AA antiproton production target

    CERN Multimedia

    CERN PhotoLab

    1979-01-01

    The first version of the antiproton production target was a tungsten rod, 11 cm long (actually a row of 11 rods, each 1 cm long) and 3 mm in diameter. The rod was embedded in graphite, pressure-seated into an outer casing made of stainless steel. The casing had fins for forced-air cooling. In this picture, the 26 GeV high-intensity beam from the PS enters from the right, where a scintillator screen, with circles every 5 mm in radius, permits precise aim at the target centre. See also 7903034 and 7905094.

  7. Aquaporin-2 membrane targeting

    DEFF Research Database (Denmark)

    Olesen, Emma T B; Fenton, Robert A

    2017-01-01

    The targeting of the water channel aquaporin-2 (AQP2) to the apical plasma membrane of kidney collecting duct principal cells is regulated mainly by the antidiuretic peptide hormone arginine vasopressin (AVP). This process is of crucial importance for the maintenance of body water homeostasis...

  8. ISOLDE back on target

    CERN Multimedia

    Anaïs Schaeffer

    2014-01-01

    Today, Friday 1 August, the ISOLDE installation, supplied by the beams of the PS Booster, restarted its physics programme. After a shutdown of almost a year and a half, there was a real buzz in the air as the first beam of protons hit the target of the first post-LS1 ISOLDE experiment.   One of the new target-handling robots installed by ISOLDE during LS1. Many improvements have been made to the ISOLDE installation during LS1. One of the main projects was the installation of new robots for handling the targets (see photo 1). “Our targets are bombarded by protons from the PS Booster’s beams and become very radioactive,” explains Maria Jose Garcia Borge, spokesperson for the ISOLDE collaboration. “They therefore need to be handled carefully, which is where the robots come in. The robots we had until now were already over 20 years old and were starting to suffer from the effects of radiation. So LS1 was a perfect opportunity to replace them with more moder...

  9. Microenvironmental targets in sarcoma

    Directory of Open Access Journals (Sweden)

    Monika eEhnman

    2015-11-01

    Full Text Available Sarcomas are rare malignant tumors affecting all age groups. They are typically classified according to their resemblance to corresponding normal tissue. Their heterogeneous features, for example in terms of disease-driving genetic aberrations and body location, complicate both disease classification and development of novel treatment regimens. Many years of failure of improved patient outcome in clinical trials has lead to the conclusion that novel targeted therapies are likely needed in combination with current multimodality regimens. Sarcomas have not, in contrast to the common carcinomas, been the subject for larger systematic studies on how tumor behavior relates to characteristics of the tumor microenvironment. There is consequently an urgent need for identifying suitable molecular targets, not only in tumor cells, but also in the tumor microenvironment. This review discusses preclinical and clinical data about potential molecular targets in sarcomas. Studies on targeted therapies involving the tumor microenvironment are prioritized. A greater understanding of the biological context is expected to facilitate more successful design of future clinical trials in sarcoma.

  10. Target Heart Rates

    Science.gov (United States)

    ... is your level of intensity? When is the best time of day to work out? Target Heart Rates Warm Up, Cool Down See More >> Getting Active Getting Started - Tips for Long-term Exercise Success Get Moving: Easy Tips to Get Active! ...

  11. Targeted Therapy for Melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Quinn, Thomas [Alphamed, Jackson, TN (United States); Moore, Herbert [Alphamed, Jackson, TN (United States)

    2016-12-05

    The research project, entitled ”Targeted Therapy for Melanoma,” was focused on investigating the use of kidney protection measures to lower the non-specific kidney uptake of the radiolabeled Pb-DOTA-ReCCMSH peptide. Previous published work demonstrated that the kidney exhibited the highest non-target tissue uptake of the 212Pb/203Pb radiolabeled melanoma targeting peptide DOTA-ReCCMSH. The radiolabeled alpha-melanocyte stimulating hormone (α-MSH) peptide analog DOTA-Re(Arg11)CCMSH, which binds the melanocortin-1 receptor over-expressed on melanoma tumor cells, has shown promise as a PRRT agent in pre-clinical studies. High tumor uptake of 212Pb labeled DOTA-Re(Arg11)CCMSH resulted in tumor reduction or eradication in melanoma therapy studies. Of particular note was the 20-50% cure rate observed when melanoma mice were treated with alpha particle emitter 212Pb. However, as with most PRRT agents, high radiation doses to the kidneys where observed. To optimize tumor treatment efficacy and reduce nephrotoxicity, the tumor to kidney uptake ratio must be improved. Strategies to reduce kidney retention of the radiolabeled peptide, while not effecting tumor uptake and retention, can be broken into several categories including modification of the targeting peptide sequence and reducing proximal tubule reabsorption.

  12. Target Chamber Manipulator

    Science.gov (United States)

    Tantillo, Anthony; Watson, Matthew

    2015-11-01

    A system has been developed to allow remote actuation of sensors in a high vacuum target chamber used with a particle accelerator. Typically, sensors of various types are placed into the target chamber at specific radial and angular positions relative to the beam line and target. The chamber is then evacuated and the experiments are performed for those sensor positions. Then, the chamber is opened, the sensors are repositioned to new angles or radii, and the process is repeated, with a separate pump-down cycle for each set of sensor positions. The new sensor positioning system allows scientists to pre-set the radii of up to a dozen sensors, and then remotely actuate their angular positions without breaking the vacuum of the target chamber. This reduces the time required to reposition sensors from 6 hours to 1 minute. The sensors are placed into one of two tracks that are separately actuated using vacuum-grade stepping motors. The positions of the sensors are verified using absolute optical rotary encoders, and the positions are accurate to 0.5 degrees. The positions of the sensors are electronically recorded and time-stamped after every change. User control is through a GUI using LabVIEW.

  13. Active Target Simulation

    Science.gov (United States)

    Smith, Nathan; Draznik, Peter; Frank, Nathan

    2012-10-01

    We have simulated an existing experimental design to determine the resolution improvement upon energy measurements of neutron unbound nuclei. A number of experiments of this type have been performed at the National Superconducting Cyclotron Laboratory (NSCL), located at Michigan State University. An excited nucleus is typically produced with a radioactive beam interacting with a passive Beryllium target. Many different nuclei are produced in experiment, each of which immediately decays into a charged particle and neutron. The charged particles are detected and the neutrons interact in scintillation detectors such as the Modular Neutron Array (MoNA) and Large Multi-Institutional Scintillation Array (LISA). In our simulation, we have constructed an active target that provides additional information such that the point of nuclear interaction within the target may be determined. This information improves the resolution in decay energy measurements of neutron unbound isotopes. This presentation will cover some aspects of the simulation process, as well as showing some of the results that demonstrate the simulated improvement over a passive target.

  14. Feasibility study of an active target for the MEG experiment

    Energy Technology Data Exchange (ETDEWEB)

    Papa, A., E-mail: angela.papa@psi.ch [Paul Scherrer Institut PSI, CH-5232 Villigen (Switzerland); Cavoto, G. [INFN Sezione di Roma, P.le Aldo Moro, 2, 00185 Roma (Italy); Ripiccini, E. [INFN Sezione di Roma, P.le Aldo Moro, 2, 00185 Roma (Italy); Dipartimento di Fisica dell' Università degli studi di Roma, P.le Aldo Moro, 2, 00185 Roma (Italy)

    2014-03-01

    We consider the possibility to have an active target for the upgrade of the MEG experiment (MEG II). The active target should work as (1) a beam monitoring, to continuously measure the muon stopping rate and therefore provide a direct evaluation of the detector acceptance (or an absolute normalization of the stopped muon); and as (2) an auxiliary device for the spectrometer, to improve the determination of the muon decay vertex and consequently to achieve a better positron momentum and angular resolutions, detecting the positron from the muon decay. In this work we studied the feasibility of detecting minimum ionizing particle with a single layer of 250 μm fiber and the capability to discriminate between the signal induced by either a muon or a positron.

  15. Production asymmetry of $\\Lambda^0$ and ${\\overline{\\Lambda}}^0$ in $\\pi^{\\pm}$, $K^{\\pm}$, p - nucleon collisions at 250 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Nicola, Marcello Santo [Brazilian Center for Physics Research, Rio de Janeiro (Brazil)

    2001-02-01

    Using data from Fermilab xed-target experiment E769, we have measured particleantiparticle production asymmetries for Λ0 hyperons in π± - nucleon interactions, K ± - nucleon interactions and p - nucleon interactions at 250 GeV/c. The asymmetries are measured as functions of Feynman-x (xf ) and pT2 over the ranges 0 ≤ pT2 ≤ 4(GeV/c)2 and -0.12 ≤ xF ≤ 0.12 (for positive beam) and 0 ≤ pT2 ≤ 10(GeV/c)2 and -0.16 ≤ xF ≤ 0:.0 for the negative beam. We find substantial asymmetries, even at xF = 0. We also observe leading-particle-type asymmetries which qualitatively agree with theoretical predictions.

  16. Strut-based accelerated partial breast irradiation: Report of treatment results for 250 consecutive patients at 5 years from a multicenter retrospective study.

    Science.gov (United States)

    Yashar, Catheryn; Attai, Deanna; Butler, Ernest; Einck, John; Finkelstein, Steven; Han, Ben; Hong, Robert; Komarnicky, Lydia; Lyden, Maureen; Mantz, Constantine; Morcovescu, Serban; Nigh, Stephen; Perry, Kerri; Pollock, Jondavid; Reiff, Jay; Scanderbeg, Daniel; Snyder, Margaret; Kuske, Robert

    This registry trial studied the long-term outcomes of women receiving accelerated partial breast irradiation (APBI) using strut-based applicators and reports on the local control, toxicity, and survival for the first 250 patients treated with this device. Patients were treated using the strut-based brachytherapy device with conventional dose and fractionation of 34 Gy in 10 twice-daily fractions. Planning goals for the planning target volume were V90 > 90%, V150 skin bridge, the median skin max doses were 272 and 289 cGy, respectively. The 4-year actuarial recurrence rates for true recurrence/marginal miss and ipsilateral breast tumor recurrence were 2.3% and 3.6%, respectively. The 4-year actuarial rates for overall survival, cause-specific survival, and disease-free survival were 97%, 98%, and 92%, respectively. The strut-based applicator was designed to simplify APBI compared to interstitial brachytherapy. This report confirms excellent tumor control and survival with low toxicity and supports the evidence that brachytherapy has less normal tissue toxicity than APBI with external beam irradiation. Copyright © 2016 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  17. TOPOAFRICA project: reconstruction and quantification of the past topography of Africa over the last 250 My.

    Science.gov (United States)

    Guillocheau, François

    2010-05-01

    The goal of this project is to quantify the growth of long wavelength (x1000 km) topography over the last 250 My at the scale of a continent - Africa - and to understand (1) their relationship with the underlying mantle dynamics over such a time period and (2) their consequence over some Earth surface processes. Most studies of past topography reconstruction have focused on orogenic areas. Few efforts have been devoted to characterizing the more subtle long wavelength topography, such as the doming or plateau uplift of continental areas at the 1000 km wavelength, with a paleoelevation of few hundreds of meters to a maximum of 1000-2000m. A direct inversion of the geological data into estimates of paleotopography is difficult. Quantification of past topographies of a continent requires coupling of geological data with a sediment production (erosion) and transport numerical model. The quantification of the Meso-Cenozoic topographies of the African continent is based on uplift (mean time interval 10 my) and paleoprecipitation maps (input of the model) and siliciclastic sedimentary fluxes and thermochronological data. One of the advance of this project is to draw new-style paleogeographic reconstructions focussed on the continental environments yielding the geometry of paleocatchments, the lacustrine baselevel, the type and the flow direction of the fluvial systems… All those data are registered in database and GIS (ArcGis). Uncertainties are quantified. The uplift maps, in a first step semi-quantitative, are based on the paleogeographical changes and on synthesis of the tectonically induced-unconformities both onland and offhore (seismic) and their consequences (incised valleys, forced-regression wedges, changes of weathering types….). The paleoprecipitation maps are product by coupling climatic numerical models with a geological database (GIS) including all the climate recorders (lithology, type of clays, paleosoils; woods, pollens…). The measure of the

  18. Targeting the adolescent male.

    Science.gov (United States)

    Pitt, E

    1986-01-01

    The National Urban League regards too early parenting among adolescents as an issue requiring high level, active attention from all segments of the Black community. Poverty, single parent households and adolescent pregnancies are not exclusively female problems. The role that males play has been missing from too many studies of these phenomena. In light of the fact that most sexual activity is male initiated, and most sexual behavior is male influenced, it becomes clear that there will be no resolution of the problem of teenage pregnancy without directing greater attention to the male. The issue of male responsibility is skirted too often due to parental pride on the part of mothers and fathers when their male children seek sexual relations with female partners. It is viewed as a sign that they are developing sexually within the norm. This is especially true, in many instances, in female headed households where the mother is concerned that she may not be providing her son with an adequate male role model. Sexual activity by female adolescents, however, is generally not condoned. This confusing double standard is further compounded by the disjointed fashion in which American society responds to adolescent sexuality on the whole. Although the home should be the focal point, many parents reluctantly admit an inability to communicate effectively about sex with their pre-adolescent children. Thus, the school, church, community and social agencies have all been enlisted in this task. The National Urban League's initiative in this area is expected to have significant impact on the course of adolescent sexuality and reproductive responsibility.(ABSTRACT TRUNCATED AT 250 WORDS)

  19. Does the Loss of ARID1A (BAF-250a Expression in Endometrial Clear Cell Carcinomas Have Any Clinicopathologic Significance? A Pilot Assessment

    Directory of Open Access Journals (Sweden)

    Oluwole Fadare, Idris L. Renshaw, Sharon X. Liang

    2012-01-01

    Full Text Available SWI/SNF chromatin-modification complexes use the energy of ATP hydrolysis to remodel nucleosomes and to affect transcription and several cellular processes. Accordingly, their loss of function has been associated with malignant transformation. ARID1A (the expression of whose product, BAF250a, a key complex component, is lost when mutated has recently been identified as a tumor suppressor gene that is mutated in 46-57% of ovarian clear cell carcinoma (CCC. The purposes of this study are to assess the frequency of loss of BAF250a expression in endometrial CCC and whether this loss has any discernable clinicopathologic implications. 34 endometrial carcinomas with a CCC component (including 22 pure CCC, 8 mixed carcinomas with a 10% CCC component, and 4 carcinosarcomas with a CCC epithelial component, were evaluated by immunohistochemistry using a monoclonal antibody directed against the human BAF250a protein. 5 (22.7% of the 22 pure CCC were entirely BAF250a negative, whereas the remainder showed diffuse immunoreactivity. None of 4 carcinosarcomas and only 1 (12.5% of the 8 mixed carcinomas were BAF250a negative. There was no discernable relationship between BAF250a immunoreactivity status and tumor architectural patterns (solid, papillary or tubulocystic areas or cell type (flat, hobnail or polygonal. Of the 22 patients with pure CCC, 14, 2, 3, and 3 were International Federation of Gynecology and Obstetrics stages 1, II, III and IV respectively. Interestingly, all 5 BAF250a negative cases were late stage [stages III or IV] as compared with 1 of 17 BAF250a positive cases (p=0.0002. Thus, 83% (5/6 of all late stage cases were BAF250a [-], as compared with 0 (0% of the 16 early stage (I or II cases (p=.0002. BAF250a negative and positive cases did not show any statistically significant difference regarding patient age and frequency of lymphovascular invasion or myometrial invasion. As may be anticipated from the concentration of late stage cases in

  20. Physics of polarized targets

    CERN Document Server

    Niinikoski, Tapio

    2014-01-01

    For developing, building and operating solid polarized targets we need to understand several fields of physics that have seen sub stantial advances during the last 50 years. W e shall briefly review a selection of those that are important today. These are: 1) quantum statistical methods to describe saturation and relaxation in magnetic resonance; 2) equal spin temperature model for dy namic nuclear polarization; 3 ) weak saturation during NMR polarization measurement; 4 ) refrigeration using the quantum fluid properties of helium isotopes. These, combined with superconducting magnet technologies, permit today to reach nearly complete pola rization of almost any nuclear spins. Targets can be operated in frozen spin mode in rather low and inhomogeneous field of any orientation, and in DNP mode in beams of high intensity. Beyond such experiments of nuclear and particle physics, applications a re also emerging in macromolecular chemistry and in magnetic resonance imaging. This talk is a tribute to Michel Borghini...

  1. Emerging Targets in Photopharmacology.

    Science.gov (United States)

    Lerch, Michael M; Hansen, Mickel J; van Dam, Gooitzen M; Szymanski, Wiktor; Feringa, Ben L

    2016-09-05

    The field of photopharmacology uses molecular photoswitches to establish control over the action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of resistance, while achieving unprecedented precision in treatment. By using small molecules, photopharmacology provides a viable alternative to optogenetics. We present here a critical overview of the different pharmacological targets in various organs and a survey of organ systems in the human body that can be addressed in a non-invasive manner. We discuss the prospects for the selective delivery of light to these organs and the specific requirements for light-activatable drugs. We also aim to illustrate the druggability of medicinal targets with recent findings and emphasize where conceptually new approaches have to be explored to provide photopharmacology with future opportunities to bring "smart" molecular design ultimately to the realm of clinical use. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Inflation Targeting: Provisional Results

    Directory of Open Access Journals (Sweden)

    Cerna, Silviu

    2010-06-01

    Full Text Available Inflation targeting monetary policy framework that requires the central bank to achieve a low inflation has contributed to price stability in industrialized countries. As well as the other developing countries, ex communist countries have also tried to apply this strategy, which was susceptible to increase monetary policy transparency and to determine authorities to make necessary reforms in order to pass from a planned to a market economy. In Romania, inflation targeting has contributed, to a large extent, to price increase smoothening, without affecting economic growth. Knowing the factors that have determined this unquestionable success allows for not only understanding the Romanian transition process, but also draw some useful conclusions in view of the necessary actions for adopting the euro.

  3. Foucault on targets.

    Science.gov (United States)

    Lynch, John

    2004-01-01

    This paper seeks to gain an insight into the behavior of a large NHS trust, in its attempt to meet a 90 percent patient access target, in a week long national audit in March 2003. Why did individuals act in dramatically different ways to their norm over this period. The work of Michel Foucault is used to explore these issues. The discourses of power, knowledge, discipline and governmentality are identified as key foucaudian themes that offer an alternative interpretation of how individuals behave in their place of work. The importance of the historical context of discourse within the NHS cannot be underestimated in shaping the behavior of individuals and groups today. Power and knowledge permeate NHS organizations through disciplinary practices and dressage. Governmentality seeks to maintain the status quo through disciplinary processes such as national healthcare targets. The natural response of NHS organizations is therefore, to seek order and conformity rather than disorder and conflict.

  4. Antibodies Targeting EMT

    Science.gov (United States)

    2017-10-01

    VLDL uptake and redistribution of lipids to cells for energy metabolism and cell signaling. ApoE overexpression has shown to be associated with a...involved in testosterone and estradiol biosynthesis, as well as prostaglandin F synthesis and has previously been implicated in cancer progression, AKR1C2...is involved in androgen metabolism and is a potential drug target for prostate cancer. AKR1C4 is involved in bile acid synthesis but has not yet

  5. Explosive Target Balances

    OpenAIRE

    Potrafke, Niklas; Reischmann, Markus

    2013-01-01

    Using the new unit root test by Phillips et al. (2011) we show that the Target balances of the German Bundesbank have been exploding from the beginning of 2009 to the beginning of 2013. By implementing a full-allotment policy and reducing the required minimum quality of collaterals in October 2008, the European Central Bank (ECB) refinanced credits in the GIIPS countries to a large extent. Private capital flowed out of the GIIPS countries (Greece, Italy, Ireland, Portugal and Spain), and the ...

  6. Two-color infrared FEL facility employing a 250-MeV linac injector of Saga synchrotron light source

    CERN Document Server

    Tomimasu, T; Koga, N; Hashiguchi, Y; Ochiai, Y; Ishibashi, M

    2001-01-01

    A two-color infrared free electron laser (FEL) facility is proposed. This FEL facility will employ a new 250-MeV linac injector of the Saga synchrotron light source (SLS). The linac has two operation modes: short macropulse mode of 1 mu s at 250 MeV is for injection to a 1.4-GeV storage ring and long macropulse mode of 13 mu s at 40 MeV is for the two-color FEL facility. The two-color FEL uses a single electron beam and simultaneously provides both infrared (IR) and far-IR laser pulses for pump-probe studies of quantum-well structures and studying vibrational relaxation of molecules. The Saga SLS will be operated in 2004 to promote material science, bio-medical and industrial applications in Kyushu.

  7. Implementing Target Value Design.

    Science.gov (United States)

    Alves, Thais da C L; Lichtig, Will; Rybkowski, Zofia K

    2017-04-01

    An alternative to the traditional way of designing projects is the process of target value design (TVD), which takes different departure points to start the design process. The TVD process starts with the client defining an allowable cost that needs to be met by the design and construction teams. An expected cost in the TVD process is defined through multiple interactions between multiple stakeholders who define wishes and others who define ways of achieving these wishes. Finally, a target cost is defined based on the expected profit the design and construction teams are expecting to make. TVD follows a series of continuous improvement efforts aimed at reaching the desired goals for the project and its associated target value cost. The process takes advantage of rapid cycles of suggestions, analyses, and implementation that starts with the definition of value for the client. In the traditional design process, the goal is to identify user preferences and find solutions that meet the needs of the client's expressed preferences. In the lean design process, the goal is to educate users about their values and advocate for a better facility over the long run; this way owners can help contractors and designers to identify better solutions. This article aims to inform the healthcare community about tools and techniques commonly used during the TVD process and how they can be used to educate and support project participants in developing better solutions to meet their needs now as well as in the future.

  8. Complete Set of Deuteron Analyzing Powers for dp Elastic Scattering at 250 MeV/nucleon and Three Nucleon Forces

    Directory of Open Access Journals (Sweden)

    Shimizu Y.

    2010-04-01

    Full Text Available Measurements of a complete set of deuteron analyzing powers (iT11, T20, T21, T22 for elastic deuteron–proton scattering at 250 MeV/nucleon have been performed with polarized deuteron beams at RIKEN RI Beam Factory. The obtained data are compared with the Faddeev calculations based on the modern nucleon–nucleon forces together with the Tucson-Melbourne’99, and UrbanaIX three nucleon forces.

  9. 12 CFR 250.220 - Whether member bank acting as trustee is prohibited by section 20 of the Banking Act of 1933 from...

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Whether member bank acting as trustee is prohibited by section 20 of the Banking Act of 1933 from acquiring majority of shares of mutual fund. 250.220 Section 250.220 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL...

  10. 12 CFR 250.408 - Short-term negotiable notes of banks not securities under section 32, Banking Act of 1933.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Short-term negotiable notes of banks not securities under section 32, Banking Act of 1933. 250.408 Section 250.408 Banks and Banking FEDERAL RESERVE... securities under section 32, Banking Act of 1933. (a) The Board of Governors has been asked whether short...

  11. 30 CFR 250.1157 - How do I receive approval to produce gas-cap gas from an oil reservoir with an associated gas cap?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I receive approval to produce gas-cap gas from an oil reservoir with an associated gas cap? 250.1157 Section 250.1157 Mineral Resources... do I receive approval to produce gas-cap gas from an oil reservoir with an associated gas cap? (a...

  12. 30 CFR 250.1156 - What steps must I take to receive approval to produce within 500 feet of a unit or lease line?

    Science.gov (United States)

    2010-07-01

    ... produce within 500 feet of a unit or lease line? 250.1156 Section 250.1156 Mineral Resources MINERALS... I take to receive approval to produce within 500 feet of a unit or lease line? (a) You must obtain... any portion of the completed interval less than 500 feet from a unit or lease line. Submit to MMS the...

  13. The Javalambre Survey Telescope (JST/T250): a multi-filter surveying machine for the Northern hemisphere

    Science.gov (United States)

    Cenarro, Javier; Marin-Franch, Antonio; Moles, Mariano; Cristobal-Hornillos, David; Dupke, Renato a.; Benitez, Txitxo; Taylor, Keith

    2015-08-01

    The Javalambre Survey Telescope (JST/T250) is a 2.55m Richey-Chretien, alt-azimuthal telescope with a field of view of diameter 3 deg and an effective etendue of 26.5 m2deg2 operated by the Centro de Estudios de Física del Cosmos de Aragón (CEFCA) at the Observatorio Astrofísico de Javalambre (OAJ). JST/T250 is particularly conceived and defined for carrying out large sky multi-filter surveys, like J-PAS (http://j-pas.org), which will be the main survey to be conducted during the first years of operation. To guarantee a seeing limited image quality all over the ~0.5m diameter focal plane, JST/T250 hosts state-of-the-arte optics, including complex hyperbolic M1 and M2 mirrors and a challenging field corrector of three lenses with 4 aspherical surfaces and high slopes. The optical configuration ends up with the powered entrance window of JPCam, the panoramic camera for J-PAS, with ~1200Mpix in a mosaic of 14 large format CCDs of 9.2k x 9.2k, and a set of 56 narrow-band, contiguous, optical filters. In this poster we present a detailed view of the telescope configuration, its optical performance and the expected operation for the J-PAS survey execution.

  14. The G-250A polymorphism in the hepatic lipase gene promoter is associated with changes in hepatic lipase activity and LDL cholesterol: The KANWU Study

    DEFF Research Database (Denmark)

    Lindi, Virpi; Schwab, Ursula; Louheranta, Anne

    2007-01-01

    acids (SFA diet) or monounsaturated fatty acids (MUFA diet). Within groups there was a second random assignment to supplements with fish oil (3.6g n-3 FA/day) or placebo. At baseline, the A-250A genotype was associated with high serum LDL cholesterol concentration (P=0.030 among three genotypes......). On the MUFA diet carriers of the A-250A genotype presented a greater decrease in LDL cholesterol concentration than subjects with other genotypes (P=0.007 among three genotypes). The rare -250A allele was related to low HL activity (P... activity among the genotypes. CONCLUSION: The A-250A genotype of the LIPC gene was associated with high LDL cholesterol concentration, but the MUFA-enriched diet reduced serum LDL cholesterol concentration especially in subjects with the A-250A genotype. Udgivelsesdato: 2008-Feb...

  15. Inflation targeting and core inflation

    OpenAIRE

    Julie Smith

    2005-01-01

    This paper examines the interaction of core inflation and inflation targeting as a monetary policy regime. Interest in core inflation has grown because of inflation targeting. Core inflation is defined in numerous ways giving rise to many potential measures; this paper defines core inflation as the best forecaster of inflation. A cross-country study finds before the start of inflation targeting, but not after, core inflation differs between non-inflation targeters and inflation targeters. Thr...

  16. Targeted therapy for sarcomas

    Directory of Open Access Journals (Sweden)

    Forscher C

    2014-03-01

    Full Text Available Charles Forscher,1 Monica Mita,2 Robert Figlin3 1Sarcoma Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; 2Experimental Therapeutics Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; 3Academic Development Program, Samuel Oschin Comprehensive Cancer Institute, and Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA Abstract: Sarcomas are tumors of mesenchymal origin that make up approximately 1% of human cancers. They may arise as primary tumors in either bone or soft tissue, with approximately 11,280 soft tissue tumors and 2,650 bone tumors diagnosed each year in the United States. There are at least 50 different subtypes of soft tissue sarcoma, with new ones described with ever-increasing frequency. One way to look at sarcomas is to divide them into categories on the basis of their genetic make-up. One group of sarcomas has an identifiable, relatively simple genetic signature, such as the X:18 translocation seen in synovial sarcoma or the 11:22 translocation seen in Ewing's sarcoma. These specific abnormalities often lead to the presence of fusion proteins, such as EWS-FLI1 in Ewing's sarcoma, which are helpful as diagnostic tools and may become therapeutic targets in the future. Another group of sarcomas is characterized by complex genetic abnormalities as seen in leiomyosarcoma, osteosarcoma, and undifferentiated sarcoma. It is important to keep these distinctions in mind when contemplating the development of targeted agents for sarcomas. Different abnormalities in sarcoma could be divided by tumor subtype or by the molecular or pathway abnormality. However, some existing drugs or drugs in development may interfere with or alter more than one of the presented pathways. Keywords: sarcoma, targeted agents, tyrosine kinase inhibitors, mTor inhibition

  17. Meeting the Aichi targets

    DEFF Research Database (Denmark)

    Funk, Stephan M; Conde, Dalia Amor; Lamoreux, John

    2017-01-01

    &s), is an excellent opportunity to achieve the Aichi 2020 Targets T11 (protected areas) and T12 (preventing species extinctions). AZE taxa have small, single-site populations that are especially vulnerable to human-induced extinctions, particularly for the many amphibians. We show that AZEs&s can be protected...... feasibly and cost-effectively, but action is urgent. We argue that the Alliance, whose initial main aim was to identify AZEs&s, must be followed up by a second-generation initiative that directs and co-ordinates AZE conservation activities on the ground. The prominent role of zoos, conservation NGOs...

  18. Polarized scintillator targets

    Science.gov (United States)

    van den Brandt, B.; Bunyatova, E. I.; Hautle, P.; Konter, J. A.; Mango, S.

    2000-05-01

    The hydrogen nuclei in an organic scintillator have been polarized to more than 80% and the deuterons in its fully deuterated version to 24%. The scintillator, doped with TEMPO, has been polarized dynamically in a field of 2.5 T in a vertical dilution refrigerator in which a plastic lightguide transports the scintillation light from the sample in the mixing chamber to a photomultiplier outside the cryostat. Sizeable solid samples with acceptable optical properties and light output have been prepared and successfully operated as "live" polarized targets in nuclear physics experiments.

  19. Polarized scintillator targets

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, B. van den E-mail: vandenbrandt@psi.ch; Bunyatova, E.I.; Hautle, P.; Konter, J.A.; Mango, S

    2000-05-21

    The hydrogen nuclei in an organic scintillator have been polarized to more than 80% and the deuterons in its fully deuterated version to 24%. The scintillator, doped with TEMPO, has been polarized dynamically in a field of 2.5 T in a vertical dilution refrigerator in which a plastic lightguide transports the scintillation light from the sample in the mixing chamber to a photomultiplier outside the cryostat. Sizeable solid samples with acceptable optical properties and light output have been prepared and successfully operated as 'live' polarized targets in nuclear physics experiments.

  20. Targeting Prostate Cancer Metastasis

    Science.gov (United States)

    2015-09-01

    achieve this goal, we cultured high-invasive prostate cancer PC3 cells and treated them with the drugs/inhibitors that were proposed to target WASF3...groups (treated by DMSO), either treated by 100 μM CYT997 or 10 μM Dasatinib suppressed the cells to spread throughout the fish body (Fig. 4). As...have scr eened t he e f fect s o f mor e t han 40 drugs on invasion using cul tur ed prost ate cancer cells and f ound t hat tar geting multiple

  1. Should the dose of tenofovir be reduced to 200–250 mg/day, when combined with protease inhibitors?

    Directory of Open Access Journals (Sweden)

    Andrew Hill

    2014-11-01

    Full Text Available Introduction: The approved dose of tenofovir disproxil fumarate, 300 mg once daily, was established in clinical trials in combination with efavirenz, which does not significantly affect tenofovir concentrations. Combining tenofovir with lopinavir/r, darunavir/r or atazanavir/r increases tenofovir concentrations, which could raise the risk of renal adverse events. Newly approved tenofovir tablets are available at lower strength (200 or 250 mg for use in paediatrics. Methods: A literature search was used to assess the effects of lopinavir/r, darunavir/r and atazanavir/r on tenofovir plasma Cmax, AUC and Cmin (Geometric Mean Ratio and 90% confidence intervals. Assuming linear dose-proportional pharmacokinetics (as observed in dose-ranging studies, the 250 mg tablet was predicted to achieve plasma concentrations 17% lower than the 300 mg dose, and the 200 mg tablet to achieve plasma levels 33% lower. Effects on tenofovir plasma Cmax, AUC and Cmin concentrations were assessed for combined dosing of each protease inhibitor with 250 or 200 mg daily doses of tenofovir, versus standard dose tenofovir (300 mg daily without protease inhibitors. Results: In drug-drug interaction studies, lopinavir/ritonavir significantly increased tenofovir Cmax, AUC and Cmin. Effects of each PI on tenofovir Cmin were greater than effects on Cmax or AUC. Using a 250 mg paediatric dose of tenofovir with lopinavir/ritonavir, tenofovir Cmin was predicted to remain higher than tenofovir 300 mg used with efavirenz (GMR=1.26, 95% CI 1.14–1.38. Similar results were observed for use of tenofovir 250 mg with atazanavir/ritonavir (GMR=1.07, 95% CI 1.01–1.13 and with darunavir/ritonavir (GMR=1.14, 95% CI 0.99–1.31. Predicted tenofovir AUC levels for the 250 mg dose with protease inhibitors were all within the bioequivalence range, relative to use with efavirenz. Using a 200 mg paediatric dose of tenofovir with lopinavir/ritonavir, the tenofovir Cmin was predicted to be

  2. Targeting Nuclear Thymidylate Biosynthesis

    Science.gov (United States)

    Chon, James; Stover, Patrick J.; Field, Martha S.

    2016-01-01

    Thymidylate (dTMP) biosynthesis plays an essential and exclusive function in DNA synthesis and proper cell division, and therefore has been an attractive therapeutic target. Folate analogues, known as antifolates, and nucleotide analogs that inhibit the enzymatic action of the de novo thymidylate biosynthesis pathway and are commonly used in cancer treatment. In this review, we examine the mechanisms by which the antifolate 5-fluorouracil, as well as other dTMP synthesis inhibitors, function in cancer treatment in light of emerging evidence that dTMP synthesis occurs in the nucleus. Nuclear localization of the de novo dTMP synthesis pathway requires modification of the pathway enzymes by the small ubiquitin-like modifier (SUMO) protein. SUMOylation is required for nuclear localization of the de novo dTMP biosynthesis pathway, and disruption in the SUMO pathway inhibits cell proliferation in several cancer models. We summarize evidence that the nuclear localization of the dTMP biosynthesis pathway is a critical factor in the efficacy of antifolate-based therapies that target dTMP synthesis. PMID:27876557

  3. Targeted corneal transplantation.

    Science.gov (United States)

    Jhanji, Vishal; Mehta, Jod S; Sharma, Namrata; Sharma, Bhavana; Vajpayee, Rasik B

    2012-07-01

    Corneal transplantation surgery has moved from an era of conventional penetrating keratoplasty to selective replacement of the diseased corneal layer with complementary healthy donor corneal tissue. Anterior lamellar transplantation surgeries do not involve replacement of corneal endothelium, consequently eliminating the occurrence of endothelial rejection. Similarly, in diseases affecting the corneal endothelium, selective replacement with a lamellar lenticule bearing healthy endothelium provides better outcomes in terms of ocular surface, lesser astigmatism and quick visual recovery. In addition to the advantages of enhanced surgical outcomes, targeted corneal transplantation allows the use of one donor cornea for more than one recipient, thereby offering a viable solution to the problem of paucity of donor corneas. Evolving techniques of corneal transplantation have enabled better utilization of donor corneal tissue. Anterior lamellar as well as endothelial keratoplasty surgeries have become first-choice surgeries in appropriately selected cases. This review briefly discusses some of these novel surgical techniques. A better understanding of targeted corneal transplantation would lead to adaptation of the concept of component corneal surgery. This would further enable the corneal surgeons to circumvent the problem of donor corneal shortage especially in the developing world.

  4. Fixed target beams

    CERN Document Server

    Kain, V; Cettour-Cave, S; Cornelis, K; Fraser, M A; Gatignon, L; Goddard, B; Velotti, F

    2017-01-01

    The CERN SPS (Super Proton Synchrotron) serves asLHC injector and provides beam for the North Area fixedtarget experiments. At low energy, the vertical acceptancebecomes critical with high intensity large emittance fixed tar-get beams. Optimizing the vertical available aperture is a keyingredient to optimize transmission and reduce activationaround the ring. During the 2016 run a tool was developed toprovide an automated local aperture scan around the entirering.The flux of particles slow extracted with the1/3inte-ger resonance from the Super Proton Synchrotron at CERNshould ideally be constant over the length of the extractionplateau, for optimum use of the beam by the fixed target ex-periments in the North Area. The extracted intensity is con-trolled in feed-forward correction of the horizontal tune viathe main SPS quadrupoles. The Mains power supply noiseat 50 Hz and harmonics is also corrected in feed-forwardby small amplitude tune modulation at the respective fre-quencies with a dedicated additional quad...

  5. Old Drug, New Target

    Science.gov (United States)

    Andrews, William J.; Panova, Tatiana; Normand, Christophe; Gadal, Olivier; Tikhonova, Irina G.; Panov, Konstantin I.

    2013-01-01

    Transcription by RNA polymerase I (Pol-I) is the main driving force behind ribosome biogenesis, a fundamental cellular process that requires the coordinated transcription of all three nuclear polymerases. Increased Pol-I transcription and the concurrent increase in ribosome biogenesis has been linked to the high rates of proliferation in cancers. The ellipticine family contains a number of potent anticancer therapeutic agents, some having progressed to stage I and II clinical trials; however, the mechanism by which many of the compounds work remains unclear. It has long been thought that inhibition of Top2 is the main reason behind the drugs antiproliferative effects. Here we report that a number of the ellipticines, including 9-hydroxyellipticine, are potent and specific inhibitors of Pol-I transcription, with IC50 in vitro and in cells in the nanomolar range. Essentially, the drugs did not affect Pol-II and Pol-III transcription, demonstrating a high selectivity. We have shown that Pol-I inhibition occurs by a p53-, ATM/ATR-, and Top2-independent mechanism. We discovered that the drug influences the assembly and stability of preinitiation complexes by targeting the interaction between promoter recognition factor SL1 and the rRNA promoter. Our findings will have an impact on the design and development of novel therapeutic agents specifically targeting ribosome biogenesis. PMID:23293027

  6. Quantum state targeting

    Science.gov (United States)

    Rudolph, Terry; Spekkens, Robert W.

    2004-11-01

    We introduce a primitive for quantum cryptography that we term “state targeting.” We show that increasing one’s probability of success in this task above a minimum amount implies an unavoidable increase in the probability of a particular kind of failure. This is analogous to the unavoidable disturbance to a quantum state that results from gaining information about its identity, and can be shown to be a purely quantum effect. We solve various optimization problems for state targeting that are useful for the security analysis of two-party cryptographic tasks implemented between remote antagonistic parties. Although we focus on weak coin flipping, the results are significant for other two-party protocols, such as strong coin flipping, partially binding and concealing bit commitment, and bit escrow. Furthermore, the results have significance not only for the traditional notion of security in cryptography, that of restricting a cheater’s ability to bias the outcome of the protocol, but also for a different notion of security that arises only in the quantum context, that of cheat sensitivity. Finally, our analysis leads to some interesting secondary results, namely, a generalization of Uhlmann’s theorem and an operational interpretation of the fidelity between two mixed states.

  7. Target Housing Material Options

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-02-11

    With gas cooling, heat transfer coefficients are low compared to water. The benefit of gas from a heat transfer point of view is that there is really no upper temperature limit for the coolant, as compared to water, which is limited ultimately by the critical point, and in practice the critical heat flux. In our case with parallel flow channels, water is limited to even lower operating limits by nucleate boiling. So gas can get as hot as the containment material will allow, but to get the density and heat transfer up to something reasonable, we must also increase pressure, thus increasing stress on the containment, namely the front and back faces. We are designing to ASME BPVC, which, for most materials allows a maximum stress of UTS/3. So we want the highest possible UTS. For reference, the front face stress in the 12 mm target at 300 psi was about 90 MPa. The inconel 718 allowable stress at 900°C is 1/3 of 517 or 172 MPa. So we are in a very safe place, but the uTS is dropping rapidly with temperature above 900°C. As we increase target diameter, the challenge will be to keep the stress down. We are probably looking at keeping the allowable at or above the present value, and at as high a temperature as possible.

  8. Targeting adipose tissue

    Directory of Open Access Journals (Sweden)

    Haas Bodo

    2012-10-01

    Full Text Available Abstract Two different types of adipose tissues can be found in humans enabling them to respond to starvation and cold: white adipose tissue (WAT is generally known and stores excess energy in the form of triacylglycerol (TG, insulates against cold, and serves as a mechanical cushion. Brown adipose tissue (BAT helps newborns to cope with cold. BAT has the capacity to uncouple the mitochondrial respiratory chain, thereby generating heat rather than adenosine triphosphate (ATP. The previously widely held view was that BAT disappears rapidly after birth and is no longer present in adult humans. Using positron emission tomography (PET, however, it was recently shown that metabolically active BAT occurs in defined regions and scattered in WAT of the adult and possibly has an influence on whole-body energy homeostasis. In obese individuals adipose tissue is at the center of metabolic syndrome. Targeting of WAT by thiazolidinediones (TZDs, activators of peroxisome proliferator-activated receptor γ (PPARγ a ‘master’ regulator of fat cell biology, is a current therapy for the treatment of type 2 diabetes. Since its unique capacity to increase energy consumption of the body and to dissipate surplus energy as heat, BAT offers new perspectives as a therapeutic target for the treatment of obesity and associated diseases such as type 2 diabetes and metabolic syndrome. Recent discoveries of new signaling pathways of BAT development give rise to new therapeutic possibilities in order to influence BAT content and activity.

  9. Targeting adipose tissue.

    Science.gov (United States)

    Haas, Bodo; Schlinkert, Paul; Mayer, Peter; Eckstein, Niels

    2012-10-27

    Two different types of adipose tissues can be found in humans enabling them to respond to starvation and cold: white adipose tissue (WAT) is generally known and stores excess energy in the form of triacylglycerol (TG), insulates against cold, and serves as a mechanical cushion. Brown adipose tissue (BAT) helps newborns to cope with cold. BAT has the capacity to uncouple the mitochondrial respiratory chain, thereby generating heat rather than adenosine triphosphate (ATP). The previously widely held view was that BAT disappears rapidly after birth and is no longer present in adult humans. Using positron emission tomography (PET), however, it was recently shown that metabolically active BAT occurs in defined regions and scattered in WAT of the adult and possibly has an influence on whole-body energy homeostasis. In obese individuals adipose tissue is at the center of metabolic syndrome. Targeting of WAT by thiazolidinediones (TZDs), activators of peroxisome proliferator-activated receptor γ (PPARγ) a 'master' regulator of fat cell biology, is a current therapy for the treatment of type 2 diabetes. Since its unique capacity to increase energy consumption of the body and to dissipate surplus energy as heat, BAT offers new perspectives as a therapeutic target for the treatment of obesity and associated diseases such as type 2 diabetes and metabolic syndrome. Recent discoveries of new signaling pathways of BAT development give rise to new therapeutic possibilities in order to influence BAT content and activity.

  10. Development of an Automated Target Oscillator For Use in Reaction Studies

    Science.gov (United States)

    Martin, William; Bardayan, D. W.; Jones, K. L.; Cizewski, J. A.

    2009-10-01

    When a high current (greater than 10^6 particles per second) of heavy ion beam bombards a plastic target, the energy deposition and heat buildup can cause target degradation. In the case of calibration/pilot beams used on thin (100-250μg/cm2) deuterated polyethylene targets, even a short exposure has been found to result in damages such as cracking, burn through, and target carbonization/oxidation. One way to reduce the deleterious effects of this accumulated energy is to oscillate the target, thereby spreading the deposited energy over a larger area and allowing for an increased rate of heat dissipation. At the HRIBF in Oak Ridge, an automated target oscillation system has been developed using an electronic stepper motor and a control unit equipped with a custom Field Programmable Gated Array (FPGA) circuit board. Taking into consideration varying target sizes and beam densities, the algorithm loaded onto the FPGA allows the user to adjust both the frequency and amplitude of oscillation. Conclusive testing shows that incorporation of the target oscillator apparatus introduces no detectable electromagnetic noise to the detector array. Live beam testing is planned in the near future, and it is anticipated that the target oscillator will greatly assist HRIBF's efforts to maintain target integrity during calibration and experiments.

  11. Low intensity beam target unit

    CERN Multimedia

    CERN PhotoLab

    1976-01-01

    This is a wheel fitted with many targets around its periphery (each with three longitudinally arranged thin rods) of which one is placed into the beam via a rotation of the wheel. Upstream of each target is placed a luminescent screen, aligbed on each target axis and viewed with a TV camera, to make sure that one is hitting the target. This target unit was probably used to study target's behaviour (like beam heating). Gualtiero Del Torre stands on the left, Pierre Gerdil on the right.

  12. Development and validation of a liquid chromatography-tandem mass spectrometry method for the identification and quantification of JWH-018, JWH-073, JWH-019, and JWH-250 in human whole blood.

    Science.gov (United States)

    Kacinko, Sherri L; Xu, Allan; Homan, Joseph W; McMullin, Matthew M; Warrington, Donna M; Logan, Barry K

    2011-09-01

    A sensitive and specific method for the quantification of JWH-018, JWH-073, and JWH-250 and the qualitative identification of JWH-019 in whole blood was developed and validated. Samples fortified with JWH-018-d₉ and JWH-073-d₉ underwent liquid-liquid extraction and were analyzed by liquid chromatography-positive ion electrospray ionization-tandem mass spectrometry. Two transitions were monitored for all analytes except JWH-250, for which there was only one available transition. JWH-019 did not meet the stringent requirements for quantitative analysis, and thus this method is only appropriate for the qualitative identification of this compound in whole blood. The linear range was 0.1-20 μg/L for all quantitative analytes. The maximum average within and between-run imprecision was 7.9% and 10.2%, respectively, and all controls quantified within 8.2% of target concentrations. Process efficiency, a measurement that takes into effect extraction efficiency and matrix effect, was ≥ 32.0% for all quantitative analytes; similar results were obtained for the deuterated internal standards. All analytes were stable at room, refrigerated, and frozen temperatures for at least 30 days. The method was used to quantify JWH-018 and JWH-073 in a blood specimen collected from a person known to have used an herbal incense blend containing these substances.

  13. Issues in Target Tracking

    Science.gov (United States)

    2010-05-01

    simulations we take as ground truth that the target moves at 10m/s heading west and 5m/s heading north, starting from ( 5000m , 35000m). The emitted frequency is... runs , the estimated initial and final positions fall into the 99% confidence region. −1 −0.8 −0.6 −0.4 −0.2 0 0.2 0.4 0.6 0.8 1 x 10 4 0 0.5 1 1.5 2 2.5...position of trajectories. “F”: final position of trajectories. Right: The true and estimated trajectories from 100 Monte Carlo runs for Johnson noise

  14. Bradycardia During Targeted Temperature Management

    DEFF Research Database (Denmark)

    Thomsen, Jakob Hartvig; Nielsen, Niklas; Hassager, Christian

    2016-01-01

    OBJECTIVES: Bradycardia is common during targeted temperature management, likely being a physiologic response to lower body temperature, and has recently been associated with favorable outcome following out-of-hospital cardiac arrest in smaller observational studies. The present study sought...... to confirm this finding in a large multicenter cohort of patients treated with targeted temperature management at 33°C and explore the response to targeted temperature management targeting 36°C. DESIGN: Post hoc analysis of a prospective randomized study. SETTING: Thirty-six ICUs in 10 countries. PATIENTS......: We studied 447 (targeted temperature management = 33°C) and 430 (targeted temperature management = 36°C) comatose out-of-hospital cardiac arrest patients with available heart rate data, randomly assigned in the targeted temperature management trial from 2010 to 2013. INTERVENTIONS: Targeted...

  15. High reflectance Cr/C multilayer at 250 eV for soft X-ray polarimetry

    Energy Technology Data Exchange (ETDEWEB)

    Wen, Mingwu; Jiang, Li; Zhang, Zhong; Huang, Qiushi [MOE Key Laboratory of Advanced Micro-Structured Materials, Institute of Precision Optical Engineering (IPOE), School of Physics Science and Engineering, Tongji University, Shanghai 200092 (China); Wang, Zhanshan, E-mail: wangzs@tongji.edu.cn [MOE Key Laboratory of Advanced Micro-Structured Materials, Institute of Precision Optical Engineering (IPOE), School of Physics Science and Engineering, Tongji University, Shanghai 200092 (China); She, Rui; Feng, Hua [Department of Engineering Physics, Tsinghua University, Beijing (China); Wang, Hongchang [Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE (United Kingdom)

    2015-10-01

    X-ray reflection near 45° via multilayer mirrors can be used for astronomical polarization measurements. A Cr/C multilayer mirror (designed for X-ray polarimetry at 250 eV), with a period thickness of 3.86 nm and a bi-layer number of 100, was fabricated using direct current magnetron sputtering. Grazing incidence X-ray reflectometry at 8 keV and transmission electron microscopy were used to investigate the multilayer structure. Different models were introduced to fit the hard X-ray reflectivity curve, which indicates that the layer thickness of two materials slightly drifts from the bottom to the top of the stack. Both the chromium and carbon layers are amorphous with asymmetric interfaces, while the Cr-on-C interface is slightly wider. Based on the good quality of the multilayer structure, a high reflectivity of 21.8% for the s-polarized light was obtained at 250 eV at a grazing incidence angle of 40.7°. The fabricated Cr/C multilayer mirror exhibits high reflectivity and polarization levels in the energy region of 240 eV–260 eV. - Highlights: • We fabricated Cr/C multilayer with 3.8 nm d-spacing. • X-ray reflectometry was used to determine the exact structure of Cr/C multilayer. • A high reflectivity of 21.8% for the s-polarized light was obtained at 250 eV. • Both Cr and C were found to be amorphous with slightly asymmetric interfaces. • A 4-layer model was used to fit and explain the results.

  16. Characterization of solid hydrogen targets

    Energy Technology Data Exchange (ETDEWEB)

    Fujiwara, M.C. [British Columbia Univ., Vancouver, BC (Canada); Bailey, J.M.; Mulhauser, F. [Chester Technology (United Kingdom); Beer, G.A.; Douglas, J.L.; Knowles, P.E.; Maier, M.; Mason, G.R.; Olin, A.; Porcelli, T.A. [Victoria Univ., BC (Canada); Beveridge, J.L.; Marshall, G.M. [British Columbia Univ., Vancouver, BC (Canada). TRIUMF Facility; Huber, T.M. [Gustavus Adolphus Coll., St. Peter, MN (United States); Jacot-Guillarmod, R. [Fribourg Univ. (Switzerland); Kammel, P. [Lawrence Berkeley Lab., CA (United States); Kim, S.K. [Jeonbuk National Univ., Jeonju City (Korea, Republic of); Kunselman, A.R. [Wyoming Univ., Laramie, WY (United States); Martoff, C.J. [Temple Univ., Philadelphia, PA (United States); Petitjean, C. [Paul Scherrer Inst. (PSI), Villigen (Switzerland); Zmeskal, J. [Oesterreichische Akademie der Wissenschaften, Vienna (Austria)

    1996-10-01

    In experiments using the TRIUMF solid hydrogen target system, the knowledge of the target thickness and uniformity is often essential in order to extract physical parameters from the data. We have characterized the thickness and uniformity of frozen targets using the energy loss of alpha particles. An accuracy of {approx}5% was achieved, a limit imposed by the uncertainty in the stopping powers. The details of the method are described, and the thickness calibration of the target is presented. (orig.). 11 refs.

  17. MODIS 250M burnt area detection algorithm: A case study applied, optimized and evaluated over continental Portugal.

    Science.gov (United States)

    Mota, Bernardo; Benali, Akli; Pereira, Jose Miguel

    2014-05-01

    The dependence on satellites to derive burnt area (BA) maps is unquestionable. High resolution inventories normally result from change detection algorithms applied to pre and post fire season high resolution imagery. But these have no temporal discrimination within the occurring season. Limited to the larger fire scars, coarser resolution imagery based on reflectance or thermal information can help to map the individual fire progression. The Moderate Resolution Imaging Spectroradiometer (MODIS) 250m imagery bands, freely available, can be used to provide quick areal estimates and provide the needed temporal discrimination with four times the standard spatial resolution BA products. The scope of this study is to assess the spatial and temporal accuracy of burnt area maps derived by the MODIS 250m resolution Burnt Area algorithm (M250BA) presented by Mota et al., (2013) on an Mediterranean landscape. The algorithm is an improved adaptation of one of the burnt area algorithms developed within the scope of the Fire_CCI project and was applied to an area covering continental Portugal for the period of 2001-2013. The algorithm comprises a temporal analysis based on change point detections and a spatial analysis based on Markov random fields. We explored the benefits of applying standard optimization techniques to the algorithm and achieved significant performance improvements.. Temporal and spatial accuracy assessments were performed by comparing the results with spatial and temporal distribution of active fire maps and with high resolution burnt area maps, derived by the MCD14ML thermal anomalies dataset and by Landsat BA classifications, respectively. Accuracy results highlight the potential applications for this BA algorithm and the advantages of using 250m spatial resolution images for BA detection. The study also extends the current national burnt area atlas since 2010. Due to the open-access data policy, the algorithm can be easily parameterised and applied to any

  18. Analysis of MODIS 250 m Time Series Product for LULC Classification and Retrieval of Crop Biophysical Parameter

    Science.gov (United States)

    Verma, A. K.; Garg, P. K.; Prasad, K. S. H.; Dadhwal, V. K.

    2016-12-01

    Agriculture is a backbone of Indian economy, providing livelihood to about 70% of the population. The primary objective of this research is to investigate the general applicability of time-series MODIS 250m Normalized difference vegetation index (NDVI) and Enhanced vegetation index (EVI) data for various Land use/Land cover (LULC) classification. The other objective is the retrieval of crop biophysical parameter using MODIS 250m resolution data. The Uttar Pradesh state of India is selected for this research work. A field study of 38 farms was conducted during entire crop season of the year 2015 to evaluate the applicability of MODIS 8-day, 250m resolution composite images for assessment of crop condition. The spectroradiometer is used for ground reflectance and the AccuPAR LP-80 Ceptometer is used to measure the agricultural crops Leaf Area Index (LAI). The AccuPAR measures Photosynthetically Active Radiation (PAR) and can invert these readings to give LAI for plant canopy. Ground-based canopy reflectance and LAI were used to calibrate a radiative transfer model to create look-up table (LUT) that was used to simulate LAI. The seasonal trend of MODIS-derived LAI was used to find crop parameter by adjusting the LAI simulated from climate-based crop yield model. Cloud free MODIS images of 250m resolution (16 day composite period) were downloaded using LP-DAAC website over a period of 12 months (Jan to Dec 2015). MODIS both the VI products were found to have sufficient spectral, spatial and temporal resolution to detect unique signatures for each class (water, fallow land, urban, dense vegetation, orchard, sugarcane and other crops). Ground truth data were collected using JUNO GPS. Multi-temporal VI signatures for vegetation classes were consistent with its general phenological characteristic and were spectrally separable at some point during the growing season. The MODIS NDVI and EVI multi-temporal images tracked similar seasonal responses for all croplands and were

  19. Effect of Diacetyl Monoxime Thiosemicarbazone on the Corrosion of Aged 18 Ni 250 Grade Maraging Steel in Sulphuric Acid Solution

    Directory of Open Access Journals (Sweden)

    T. Poornima

    2012-01-01

    Full Text Available The corrosion inhibition of the aged 18 Ni 250 grade maraging steel in 0.5 M sulphuric acid by diacetyl monoxime thiosemicarbazone (DAMTSC at 303–323 K has been investigated by potentiodynamic polarization, EIS, and SEM techniques. Good inhibition efficiency of DAMTSC was revealed even at low concentrations, which increased with the increase in DAMTSC concentration and decreased with the increase in temperature. The activation energies, , as well as other thermodynamic parameters (; ; , were evaluated and discussed. The adsorption of DAMTSC on the aged maraging steel surface was found to obey the Langmuir adsorption isotherm model and shows mixed type inhibition behavior.

  20. Target noise in overlay metrology

    Science.gov (United States)

    Seligson, Joel L.; Adel, Mike E.; Izikson, Pavel; Levinski, Vladimir; Yaffe, Dan

    2004-05-01

    We have developed a method for calculating the statistical effects of spatial noise on the overlay measurement extracted from a given overlay target. The method has been applied to two kinds of overlay targets on three process layers, and the new metric, Target Noise, has been shown to correlate well to the random component of Overlay Mark Fidelity. A significant difference in terms of robustness has been observed between AIM targets and conventional Frame-in-Frame targets. The results fit well into the spatial noise hierarchy presented in this paper.

  1. EURISOL High Power Targets

    CERN Document Server

    Kadi, Y; Lindroos, M; Ridikas, D; Stora, T; Tecchio, L; CERN. Geneva. BE Department

    2009-01-01

    Modern Nuclear Physics requires access to higher yields of rare isotopes, that relies on further development of the In-flight and Isotope Separation On-Line (ISOL) production methods. The limits of the In-Flight method will be applied via the next generation facilities FAIR in Germany, RIKEN in Japan and RIBF in the USA. The ISOL method will be explored at facilities including ISAC-TRIUMF in Canada, SPIRAL-2 in France, SPES in Italy, ISOLDE at CERN and eventually at the very ambitious multi-MW EURISOL facility. ISOL and in-flight facilities are complementary entities. While in-flight facilities excel in the production of very short lived radioisotopes independently of their chemical nature, ISOL facilities provide high Radioisotope Beam (RIB) intensities and excellent beam quality for 70 elements. Both production schemes are opening vast and rich fields of nuclear physics research. In this article we will introduce the targets planned for the EURISOL facility and highlight some of the technical and safety cha...

  2. Immunoscintigraphy of septic loosening of knee endoprosthesis: a retrospective evaluation of the antigranulocyte antibody BW 250/183

    Energy Technology Data Exchange (ETDEWEB)

    Klett, Rigobert; Khalisi, Alexander; Puille, Maximillian; Steiner, Dagmar; Bauer, Richard [Clinic of Nuclear Medicine, University Hospital Giessen, Friedrichstrasse 25, 35385, Giessen (Germany); Kordelle, Jens [Orthopedic Clinic, University Hospital Giessen (Germany); Stahl, Ulrich [Department of Pathology, University Hospital Giessen (Germany)

    2003-11-01

    Immunoscintigraphy with the use of the antigranulocyte antibody BW 250/183 is a reliable method for detecting infection, especially in septic loosening of hip prostheses, for which purpose quantitative interpretation of the time-activity course is employed. Therefore, we retrospectively studied whether similar results could be achieved in knee prostheses. We verified 28 scintigraphic examinations in 26 patients by histology. Scintigraphy was performed during an early (4-6 h post injection) and a late phase (23-25 h post injection). Infection was diagnosed when activity around the knee prosthesis increased by more than 10% compared with bone marrow. We found a sensitivity and a negative predictive value of 100%, a specificity of 80%, a positive predictive value of 81% and an accuracy of 89%. Specificity and accuracy are lower than in the evaluation of hip prostheses; however, in comparison to other scintigraphic modalities, scintigraphy with the antigranulocyte antibody BW 250/183 is superior in excluding infection and has better specificity and accuracy. Therefore, as in the case of hip prostheses, the described methodology appears to be the scintigraphic modality of choice for knee prostheses. (orig.)

  3. Downscaling 250-m MODIS growing season NDVI based on multiple-date landsat images and data mining approaches

    Science.gov (United States)

    Gu, Yingxin; Wylie, Bruce K.

    2015-01-01

    The satellite-derived growing season time-integrated Normalized Difference Vegetation Index (GSN) has been used as a proxy for vegetation biomass productivity. The 250-m GSN data estimated from the Moderate Resolution Imaging Spectroradiometer (MODIS) sensors have been used for terrestrial ecosystem modeling and monitoring. High temporal resolution with a wide range of wavelengths make the MODIS land surface products robust and reliable. The long-term 30-m Landsat data provide spatial detailed information for characterizing human-scale processes and have been used for land cover and land change studies. The main goal of this study is to combine 250-m MODIS GSN and 30-m Landsat observations to generate a quality-improved high spatial resolution (30-m) GSN database. A rule-based piecewise regression GSN model based on MODIS and Landsat data was developed. Results show a strong correlation between predicted GSN and actual GSN (r = 0.97, average error = 0.026). The most important Landsat variables in the GSN model are Normalized Difference Vegetation Indices (NDVIs) in May and August. The derived MODIS-Landsat-based 30-m GSN map provides biophysical information for moderate-scale ecological features. This multiple sensor study retains the detailed seasonal dynamic information captured by MODIS and leverages the high-resolution information from Landsat, which will be useful for regional ecosystem studies.

  4. Geologic Map of the Tucson and Nogales Quadrangles, Arizona (Scale 1:250,000): A Digital Database

    Science.gov (United States)

    Peterson, J.A.; Berquist, J.R.; Reynolds, S.J.; Page-Nedell, S. S.; Digital database by Oland, Gustav P.; Hirschberg, Douglas M.

    2001-01-01

    The geologic map of the Tucson-Nogales 1:250,000 scale quadrangle (Peterson and others, 1990) was digitized by U.S. Geological Survey staff and University of Arizona contractors at the Southwest Field Office, Tucson, Arizona, in 2000 for input into a geographic information system (GIS). The database was created for use as a basemap in a decision support system designed by the National Industrial Minerals and Surface Processes project. The resulting digital geologic map database can be queried in many ways to produce a variety of geologic maps. Digital base map data files (topography, roads, towns, rivers and lakes, etc.) are not included; they may be obtained from a variety of commercial and government sources. Additionally, point features, such as strike and dip, were not captured from the original paper map and are not included in the database. This database is not meant to be used or displayed at any scale larger than 1:250,000 (for example, 1:100,000 or 1:24,000). The digital geologic map graphics and plot files that are provided in the digital package are representations of the digital database. They are not designed to be cartographic products.

  5. Correlation of in vivo and in vitro measures of carbonic anhydrase IX antigen expression in renal masses using antibody 124I-cG250

    National Research Council Canada - National Science Library

    Pryma, Daniel A; O'Donoghue, Joseph A; Humm, John L; Jungbluth, Achim A; Old, Lloyd J; Larson, Steven M; Divgi, Chaitanya R

    2011-01-01

    ...)I-labeled antibody cG250. Tumor specimens obtained from resection were studied. Fifteen of these patients had clear cell cancer demonstrated by positive findings on PET/CT images and histopathology...

  6. The target effect: visual memory for unnamed search targets.

    Science.gov (United States)

    Thomas, Mark D; Williams, Carrick C

    2014-01-01

    Search targets are typically remembered much better than other objects even when they are viewed for less time. However, targets have two advantages that other objects in search displays do not have: They are identified categorically before the search, and finding them represents the goal of the search task. The current research investigated the contributions of both of these types of information to the long-term visual memory representations of search targets. Participants completed either a predefined search or a unique-object search in which targets were not defined with specific categorical labels before searching. Subsequent memory results indicated that search target memory was better than distractor memory even following ambiguously defined searches and when the distractors were viewed significantly longer. Superior target memory appears to result from a qualitatively different representation from those of distractor objects, indicating that decision processes influence visual memory.

  7. CRISM's First 'Targeted' Observation of Mars

    Science.gov (United States)

    2006-01-01

    This shows the first site on Mars imaged by the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) using its full-resolution hyperspectral capability, with a 'targeted image.' During a targeted image, CRISM's movable gimbal tracks a point on the surface, and slowly scans across it for about three minutes. The image is built up one line at a time, and each pixel in the image is measured in 544 colors covering 0.36-3.92 micrometers. During this time the Mars Reconnaissance Orbiter's range to the target starts at about 410 kilometers (250 miles), decreases to about 290 kilometers (190 miles) when the spacecraft makes its closest approach, and increases again to 410 kilometers at the end of the image. The change in geometry during image acquisition gives each CRISM targeted image a characteristic hourglass shape. This first targeted image was acquired at 1515 UTC (11:15 a.m. EDT) on Sept. 29, 2006, near 7.7 degrees south latitude, 270.5 degrees east longitude. Only minimal processing and map projection of the data have been done. At the center of the image the spatial resolution is as good as 18 meters (60 feet) per pixel. The three wavelengths shown here provide an approximate true color representation. The hourglass-shaped image covers an area about 13 kilometers (8 miles) north-south and, at the narrowest point, about 9 kilometers (5.6 miles) east-west. The upper left panel shows the image's regional context, on a mosaic from the Mars Odyssey spacecraft's Thermal Emission Imaging System (THEMIS) taken in infrared frequencies. This western part of the Valles Marineris canyon system is called Ius Chasma. The canyon system is about five kilometers (about three miles) deep and exposes ancient rocks from deep in the crust. The lower left panel shows local context, using a THEMIS visible-wavelengths image (THEMIS-VIS), which is comparable in resolution to CRISM data. Outcrops of light-toned layered rocks 1-2 kilometers (0.6-1.2 miles) across are set on ] a

  8. ERP C250 shows the elderly (cognitively normal, Alzheimer's disease) store more stimuli in short-term memory than Young Adults do.

    Science.gov (United States)

    Chapman, Robert M; Gardner, Margaret N; Mapstone, Mark; Klorman, Rafael; Porsteinsson, Anton P; Dupree, Haley M; Antonsdottir, Inga M; Kamalyan, Lily

    2016-06-01

    To determine how aging and dementia affect the brain's initial storing of task-relevant and irrelevant information in short-term memory. We used brain Event-Related Potentials (ERPs) to measure short-term memory storage (ERP component C250) in 36 Young Adults, 36 Normal Elderly, and 36 early-stage AD subjects. Participants performed the Number-Letter task, a cognitive paradigm requiring memory storage of a first relevant stimulus to compare it with a second stimulus. In Young Adults, C250 was more positive for the first task-relevant stimulus compared to all other stimuli. C250 in Normal Elderly and AD subjects was roughly the same to relevant and irrelevant stimuli in Intratrial Parts 1-3 but not 4. The AD group had lower C250 to relevant stimuli in part 1. Both normal aging and dementia cause less differentiation of relevant from irrelevant information in initial storage. There was a large aging effect involving differences in the pattern of C250 responses of the Young Adult versus the Normal Elderly/AD groups. Also, a potential dementia effect was obtained. C250 is a candidate tool for measuring short-term memory performance on a biological level, as well as a potential marker for memory changes due to normal aging and dementia. Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  9. Guidance and targeting for the Strategic Target System

    Science.gov (United States)

    White, John E.

    Guidance algorithms and targeting procedures for the Strategic Target System (STARS) launch vehicle are described. The STARS vehicle is a three stage booster, based partly upon retired Polaris A3 missile assets, which is intended to support development and testing of the Strategic Defense Initiative by delivering target payloads to the vicinity of the Kwajalein Atoll. STARS will be launched from the Kauai Test Facility located on Kauai, Hawaii. The STARS guidance objective is to deliver payloads to a prescribed target location with maximum accuracy at intercontinental ballistic missile velocities. Mission objectives are achieved with a combination of guidance algorithms.

  10. Separation of Transplutonium Elements from Neutron Irradiated Americium-241

    National Research Council Canada - National Science Library

    UENO, Kaoru; WATANABE, Kenju; SAGAWA, Chiaki; ISHIMORI, Tomitaro

    1974-01-01

    .... The ratios of the amounts present of these isotopes were determined by mass spectrometry. It was not possible to identify 249Bk in the berkelium fraction owing to the interference from other β-ray emitting nuclides. In the californium fraction, both spontaneous fission and a-activities due to 250, 252 were observed.

  11. Oxide Fiber Targets at ISOLDE

    CERN Document Server

    Köster, U; Carminati, D; Catherall, R; Cederkäll, J; Correia, J G; Crepieux, B; Dietrich, M; Elder, K; Fedosseev, V; Fraile-Prieto, L M; Franchoo, S; Fynbo, H O U; Georg, U; Giles, T; Joinet, A; Jonsson, O C; Kirchner, R; Lau, C; Lettry, Jacques; Maier, H J; Mishin, V I; Oinonen, M; Peräjärvi, K; Ravn, H L; Rinaldi, T; Santana-Leitner, M; Wahl, U; Weissman, L

    2003-01-01

    Many elements are rapidly released from oxide matrices. Some oxide powder targets show a fast sintering, thus losing their favorable release characteristics. Loosely packed oxyde fiber targets are less critical since they may maintain their open structure even when starting to fuse together at some contact points. The experience with various oxyde fiber targets (titania, zirconia, ceria and thoria) used in the last years at ISOLDE is reviewed. For short-lived isotopes of Cu, Ga and Xe the zirconia and ceria targets respectively provided significantly higher yields than any other target (metal foils, oxide powders, etc.) tested before. Titania fibers, which were not commercially available, were produced in a relic process by impregnation of a rayon felt in a titanium chloride solution and subsequent calcination by heating the dried felt in air. Thoria fibers were obtained either by the same process or by burning commercial gas lantern mantle cloth. In the future a beryllia fiber target could be used to produce...

  12. Therapeutic Targeting of Telomerase

    Directory of Open Access Journals (Sweden)

    Kathrin Jäger

    2016-07-01

    Full Text Available Telomere length and cell function can be preserved by the human reverse transcriptase telomerase (hTERT, which synthesizes the new telomeric DNA from a RNA template, but is normally restricted to cells needing a high proliferative capacity, such as stem cells. Consequently, telomerase-based therapies to elongate short telomeres are developed, some of which have successfully reached the stage I in clinical trials. Telomerase is also permissive for tumorigenesis and 90% of all malignant tumors use telomerase to obtain immortality. Thus, reversal of telomerase upregulation in tumor cells is a potential strategy to treat cancer. Natural and small-molecule telomerase inhibitors, immunotherapeutic approaches, oligonucleotide inhibitors, and telomerase-directed gene therapy are useful treatment strategies. Telomerase is more widely expressed than any other tumor marker. The low expression in normal tissues, together with the longer telomeres in normal stem cells versus cancer cells, provides some degree of specificity with low risk of toxicity. However, long term telomerase inhibition may elicit negative effects in highly-proliferative cells which need telomerase for survival, and it may interfere with telomere-independent physiological functions. Moreover, only a few hTERT molecules are required to overcome senescence in cancer cells, and telomerase inhibition requires proliferating cells over a sufficient number of population doublings to induce tumor suppressive senescence. These limitations may explain the moderate success rates in many clinical studies. Despite extensive studies, only one vaccine and one telomerase antagonist are routinely used in clinical work. For complete eradication of all subpopulations of cancer cells a simultaneous targeting of several mechanisms will likely be needed. Possible technical improvements have been proposed including the development of more specific inhibitors, methods to increase the efficacy of vaccination

  13. Target Acquisition Methodology Enhancement (TAME)

    Science.gov (United States)

    1989-03-01

    acquisition probability from COMINT, PCOM , against all communications type targets, is determined offline by a stochastic model for subsequent...of PN over all replications. F-4 f. Computes overall acquisition probability, PCOM , against all communications type targets as C: PCOM = (1. - PN...NNET where NNET denotes the number of nets which the target is in. F-6. TOTAL ACQUISITION PROBABILITY. With PNCj and PCOM computed as above, the

  14. Guidance system for laser targets

    Science.gov (United States)

    Porter, Gary D.; Bogdanoff, Anatoly

    1978-01-01

    A system for guiding charged laser targets to a predetermined focal spot of a laser along generally arbitrary, and especially horizontal, directions which comprises a series of electrostatic sensors which provide inputs to a computer for real time calculation of position, velocity, and direction of the target along an initial injection trajectory, and a set of electrostatic deflection means, energized according to a calculated output of said computer, to change the target trajectory to intercept the focal spot of the laser which is triggered so as to illuminate the target of the focal spot.

  15. Targeted nanotechnology for cancer imaging.

    Science.gov (United States)

    Toy, Randall; Bauer, Lisa; Hoimes, Christopher; Ghaghada, Ketan B; Karathanasis, Efstathios

    2014-09-30

    Targeted nanoparticle imaging agents provide many benefits and new opportunities to facilitate accurate diagnosis of cancer and significantly impact patient outcome. Due to the highly engineerable nature of nanotechnology, targeted nanoparticles exhibit significant advantages including increased contrast sensitivity, binding avidity and targeting specificity. Considering the various nanoparticle designs and their adjustable ability to target a specific site and generate detectable signals, nanoparticles can be optimally designed in terms of biophysical interactions (i.e., intravascular and interstitial transport) and biochemical interactions (i.e., targeting avidity towards cancer-related biomarkers) for site-specific detection of very distinct microenvironments. This review seeks to illustrate that the design of a nanoparticle dictates its in vivo journey and targeting of hard-to-reach cancer sites, facilitating early and accurate diagnosis and interrogation of the most aggressive forms of cancer. We will report various targeted nanoparticles for cancer imaging using X-ray computed tomography, ultrasound, magnetic resonance imaging, nuclear imaging and optical imaging. Finally, to realize the full potential of targeted nanotechnology for cancer imaging, we will describe the challenges and opportunities for the clinical translation and widespread adaptation of targeted nanoparticles imaging agents. Copyright © 2014 Elsevier B.V. All rights reserved.

  16. Targets and Secondary Beam Extraction

    Science.gov (United States)

    Noah, Etam

    2014-02-01

    Several applications make use of secondary beams of particles generated by the interaction of a primary beam of particles with a target. Spallation neutrons, bremsstrahlung photon-produced neutrons, radioactive ions and neutrinos are available to users at state-of-the-art facilities worldwide. Plans for even higher secondary beam intensities place severe constraints on the design of targets. This article reports on the main targetry challenges and highlights a variety of solutions for targetry and secondary beam extraction. Issues related to target station layout, instrumentation at the beam-target interface, safety and radioprotection are also discussed.

  17. Achieving Plant CRISPR Targeting that Limits Off-Target Effects

    Directory of Open Access Journals (Sweden)

    Jeffrey D. Wolt

    2016-11-01

    Full Text Available The CRISPR-Cas9 system (clustered regularly interspaced short palindromic repeats with associated Cas9 protein has been used to generate targeted changes for direct modification of endogenous genes in an increasing number of plant species; but development of plant genome editing has not yet fully considered potential off-target mismatches that may lead to unintended changes within the genome. Assessing the specificity of CRISPR-Cas9 for increasing editing efficiency as well as the potential for unanticipated downstream effects from off-target mutations is an important regulatory consideration for agricultural applications. Increasing genome-editing specificity entails developing improved design methods that better predict the prevalence of off-target mutations as a function of genome composition and design of the engineered ribonucleoprotein (RNP. Early results from CRISPR-Cas9 genome editing in plant systems indicate that the incidence of off-target mutation frequencies is quite low; however, by analyzing CRISPR-edited plant lines and improving both computational tools and reagent design, it may be possible to further decrease unanticipated effects at potential mismatch sites within the genome. This will provide assurance that CRISPR-Cas9 reagents can be designed and targeted with a high degree of specificity. Improved and experimentally validated design tools for discriminating target and potential off-target positions that incorporate consideration of the designed nuclease fidelity and selectivity will help to increase confidence for regulatory decision making for genome-edited plants.

  18. Literature evidence in open targets - a target validation platform.

    Science.gov (United States)

    Kafkas, Şenay; Dunham, Ian; McEntyre, Johanna

    2017-06-06

    We present the Europe PMC literature component of Open Targets - a target validation platform that integrates various evidence to aid drug target identification and validation. The component identifies target-disease associations in documents and ranks the documents based on their confidence from the Europe PMC literature database, by using rules utilising expert-provided heuristic information. The confidence score of a given document represents how valuable the document is in the scope of target validation for a given target-disease association by taking into account the credibility of the association based on the properties of the text. The component serves the platform regularly with the up-to-date data since December, 2015. Currently, there are a total number of 1168365 distinct target-disease associations text mined from >26 million PubMed abstracts and >1.2 million Open Access full text articles. Our comparative analyses on the current available evidence data in the platform revealed that 850179 of these associations are exclusively identified by literature mining. This component helps the platform's users by providing the most relevant literature hits for a given target and disease. The text mining evidence along with the other types of evidence can be explored visually through https://www.targetvalidation.org and all the evidence data is available for download in json format from https://www.targetvalidation.org/downloads/data .

  19. Transverse target spin asymmetries on a proton target at COMPASS

    CERN Document Server

    Richter, Andreas

    2009-01-01

    Transversity and transverse momentum-dependent parton distribution functions (TMDs) are been measured in semi-inclusive deep inelastic scattering (SIDIS) by using a transversely polarized target at the COMPASS experiment. COMPASS is a fixed target experiment at the CERN M2 beamline, which provides a 160GeV/c polarized m+ beam. In the years 2002-2004 COMPASS has collected data with a transversely polarized deuteron 6LiD target. In 2007, COMPASS has used for the first time a proton NH3 target. To access transversity COMPASS has used three different quark polarimeters: the Collins effect, responsible for an azimuthal asymmetry in the single hadron distribution, azimuthal target spin asymmetries of charged hadron pairs and the transverse polarisation of L hyperons. Beside this also the Sivers asymmetry arising from the correlation between the transverse nucleon spin and the quark intrinsic transverse momentum was measured. European

  20. Mapping rice-fallow cropland areas for short-season grain legumes intensification in South Asia using MODIS 250 m time-series data

    Science.gov (United States)

    Gumma, Murali Krishna; Thenkabail, Prasad S.; Teluguntla, Pardhasaradhi G.; Rao, Mahesh N.; Mohammed, Irshad A.; Whitbread, Anthony M.

    2016-01-01

    study established cropland classes based on the every 16-day 250 m normalized difference vegetation index (NDVI) time series for one year (June 2010–May 2011) of Moderate Resolution Imaging Spectroradiometer (MODIS) data, using spectral matching techniques (SMTs), and extensive field knowledge. Map accuracy was evaluated based on independent ground survey data as well as compared with available sub-national level statistics. The producers’ and users’ accuracies of the cropland fallow classes were between 75% and 82%. The overall accuracy and the kappa coefficient estimated for rice classes were 82% and 0.79, respectively. The analysis estimated approximately 22.3 Mha of suitable rice-fallow areas in South Asia, with 88.3% in India, 0.5% in Pakistan, 1.1% in Sri Lanka, 8.7% in Bangladesh, 1.4% in Nepal, and 0.02% in Bhutan. Decision-makers can target these areas for sustainable intensification of short-duration grain legumes.

  1. Hydrogen and oxygen isotope fractionation between brucite and aqueous NaCl solutions from 250 to 450°C

    Science.gov (United States)

    Saccocia, Peter J.; Seewald, Jeffrey S.; Shanks, Wayne C.

    1998-01-01

    Hydrogen and oxygen isotope fractionation factors between brucite and aqueous NaCl solutions (1000lnαbr-sw) have been calibrated by experiment from 250 to 450°C at 0.5 Kb. For D/H fractionation, 1000lnα br-sw values are as follows: −32 ± 6‰ (250°C, 3.2 wt% NaCl), −21 ± 2‰ (350°C, 10.0 wt% NaCl), and −22 ± 2‰ (450°C, 3.2 wt% NaCl), indicating that brucite is depleted in D relative to coexisting aqueous NaCl solutions. These results are in good agreement with previous D/H fractionation factors determined in the brucite-water system, indicating that any effects of dissolved salt on D/H fractionation are relatively small, particularly in solutions with near seawater salinity. The maximum salt effect (+4‰) was observed in 10.0 wt% NaCl solutions at 350°C, suggesting that the addition of dissolved NaCl increases the amount of deuterium fractionated into mineral structures. For 18O/16O fractionation, 1000lnαbr-sw values in 3.0 wt% NaCl solutions are −6.0 ± 1.3‰, −5.6 ± 0.7‰ and −4.1 ± 0.2‰, at 250, 350, and 450°C, respectively, and −5.8 ± 0.6‰ in 10.0 wt % NaCl at 350°C. These data indicate that brucite is depleted in 18O relative to coexisting aqueous NaCl solutions and that the degree of depletion decreases slightly with increasing temperature and is not strongly dependent on salinity. We calculated 18O/16O brucite-water fractionation factors from available calibrations of the salt-effect on 18O/16O fractionation between coexisting phases. The resulting values were fit to the following equation that is valid from 250 to 450°C 1000ln αbr-w = 9.54 × 106T−2 − 3.53 × 104T−1 + 26.58 where T is temperature in Kelvins. These new data have been used to improve the prediction of 18O/16O fractionation factors in the talc-water and serpentine-water systems by modifying existing empirical bond-water models. The results of this analysis indicate that the δ18O composition of talc-brucite and serpentine

  2. Construction and start-up of a 250 kW natural gas fueled MCFC demonstration power plant

    Energy Technology Data Exchange (ETDEWEB)

    Figueroa, R.A.; Carter, J.; Rivera, R.; Otahal, J. [San Diego Gas & Electric, CA (United States)] [and others

    1996-12-31

    San Diego Gas & Electric (SDG&E) is participating with M-C Power in the development and commercialization program of their internally manifolded heat exchanger (IMHEX{reg_sign}) carbonate fuel cell technology. Development of the IMHEX technology base on the UNOCAL test facility resulted in the demonstration of a 250 kW thermally integrated power plant located at the Naval Air Station at Miramar, California. The members of the commercialization team lead by M-C Power (MCP) include Bechtel Corporation, Stewart & Stevenson Services, Inc., and Ishikawajima-Harima Heavy Industries (IHI). MCP produced the fuel cell stack, Bechtel was responsible for the process engineering including the control system, Stewart & Stevenson was responsible for packaging the process equipment in a skid (pumps, desulfurizer, gas heater, turbo, heat exchanger and stem generator), IHI produced a compact flat plate catalytic reformer operating on natural gas, and SDG&E assumed responsibility for plant construction, start-up and operation of the plant.

  3. Personal dose equivalent conversion coefficients for neutron fluence over the energy range of 20-250 MeV.

    Science.gov (United States)

    Olsher, R H; McLean, T D; Justus, A L; Devine, R T; Gadd, M S

    2010-03-01

    Monte Carlo simulations were performed to extend existing neutron personal dose equivalent fluence-to-dose conversion coefficients to an energy of 250 MeV. Presently, conversion coefficients, H(p,slab)(10,alpha)/Phi, are given by ICRP-74 and ICRU-57 for a range of angles of radiation incidence (alpha = 0, 15, 30, 45, 60 and 75 degrees ) in the energy range from thermal to 20 MeV. Standard practice has been to base operational dose quantity calculations 20 MeV. Both light and heavy ions (HIs) (carbon, nitrogen and oxygen recoil nuclei) were transported down to a lower energy limit (1 keV for light ions and 5 MeV for HIs). Track energy below the limit was assumed to be locally deposited. For neutron tracks slab phantom.

  4. Development of 1000 kW molten carbonate fuel cell (MCFC) pilot plant and 250 kW stack

    Energy Technology Data Exchange (ETDEWEB)

    Mochizuki, Kenichi

    1999-07-01

    The molten carbonate fuel cell (MCFC) is expected to be ready for commercial use early in the next century. This new power generation system has a higher thermal efficiency and can reduce CO{sub 2} emissions. IHI has participated in the Ministry of International Trade and Industry's New Sunshine Program since 1993. Since joining the program, IHI has undertaken the development of the MCFC stack and 1,000 kW class power generation system under the supervision of the New Energy and Industrial Technology Development Organization and the MCFC Research Association. The development outline of the 1,000 kW MCFC pilot plant constructed at the Kawagoe test site and the present development stage of the plant control system and the 250 kW stacks developed and manufactured by IHI are described here.

  5. A rapid PCR-SSP assay for the hemochromatosis-associated Tyr250Stop mutation in the TFR2 gene.

    Science.gov (United States)

    Rivers, C A; Barton, J C; Acton, R T

    2001-01-01

    Several genes associated with hemochromatosis and primary iron overload have been identified. Mutations in the HFE gene have been detected in 60-100% of hemochromatosis patients of northern, central, and western European descent, although the frequencies of these mutations vary among racial and ethnic groups. Recently, a mutation in the gene encoding transferrin receptor-2 (exon 6, nucleotide 750 C --> G; Y250X) was detected by a PCR-restriction fragment length polymorphism (RFLP) method in Sicilians with hemochromatosis. We describe a modification of the original assay in which the sequence-specific priming PCR assay does not require the use of restriction endonuclease. The modified assay is robust and cost-efficient, and may be more useful for large-scale population studies because it can be performed rapidly on DNA extracted from buccal swabs.

  6. Electrophysiological correlates of social information processing for detecting agents in social interaction scenes: P200 and N250 components

    Directory of Open Access Journals (Sweden)

    Crivelli Davide

    2016-04-01

    Full Text Available According to interaction theories, the detection of situated agents and the understanding of their intentions and mental states are mediated by smart perceptual and embodied mechanisms. While the network supporting agency-attribution, action understanding, and grasping of others’ mental state is quite known, the actual mental chronometry of such social perception processes is still not clear. We then designed an exploratory study to investigate electrophysiological correlates (ERPs and source localization of information-processing for the detection of potential agents in realistic interaction scenes. Morphological and statistical analyses of electrophysiological data highlighted that the manipulation the nature of a potential agent, the gesture it executed and the relative position of an interagent was differently associated to the modulation of specific relevant middle-latency ERP components, labelled as P200 and N250, and of their relative intra-cortical current density distribution within the first 300 ms from the appearance of the stimulus.

  7. On artefact-free reconstruction of low-energy (30-250eV) electron holograms.

    Science.gov (United States)

    Latychevskaia, Tatiana; Longchamp, Jean-Nicolas; Escher, Conrad; Fink, Hans-Werner

    2014-10-01

    Low-energy electrons (30-250eV) have been successfully employed for imaging individual biomolecules. The most simple and elegant design of a low-energy electron microscope for imaging biomolecules is a lensless setup that operates in the holographic mode. In this work we address the problem associated with the reconstruction from the recorded holograms. We discuss the twin image problem intrinsic to inline holography and the problem of the so-called biprism-like effect specific to low-energy electrons. We demonstrate how the presence of the biprism-like effect can be efficiently identified and circumvented. The presented sideband filtering reconstruction method eliminates the twin image and allows for reconstruction despite the biprism-like effect, which we demonstrate on both, simulated and experimental examples. © 2013 Published by Elsevier B.V.

  8. Mapping Irrigated Areas Using MODIS 250 Meter Time-Series Data: A Study on Krishna River Basin (India

    Directory of Open Access Journals (Sweden)

    Andrew Nelson

    2011-01-01

    Full Text Available Mapping irrigated areas of a river basin is important in terms of assessing water use and food security. This paper describes an innovative remote sensing based vegetation phenological approach to map irrigated areas and then the differentiates the ground water irrigated areas from the surface water irrigated areas in the Krishna river basin (26,575,200 hectares in India using MODIS 250 meter every 8-day near continuous time-series data for 2000–2001. Temporal variations in the Normalized Difference Vegetation Index (NDVI pattern obtained in irrigated classes enabled demarcation between: (a irrigated surface water double crop, (b irrigated surface water continuous crop, and (c irrigated ground water mixed crops. The NDVI patterns were found to be more consistent in areas irrigated with ground water due to the continuity of water supply. Surface water availability, on the other hand, was dependent on canal water release that affected time of crop sowing and growth stages, which was in turn reflected in the NDVI pattern. Double cropped and light irrigation have relatively late onset of greenness, because they use canal water from reservoirs that drain large catchments and take weeks to fill. Minor irrigation and ground water irrigated areas have early onset of greenness because they drain smaller catchments where aquifers and reservoirs fill more quickly. Vegetation phonologies of 9 distinct classes consisting of Irrigated, rainfed, and other land use classes were also derived using MODIS 250 meter near continuous time-series data that were tested and verified using groundtruth data, Google Earth very high resolution (sub-meter to 4 meter imagery, and state-level census data. Fuzzy classification accuracies for most classes were around 80% with class mixing mainly between various irrigated classes. The areas estimated from MODIS were highly correlated with census data (R-squared value of 0.86.

  9. Desarrollo de la formulación de cefalexina 250 mg granulado para suspensión oral

    Directory of Open Access Journals (Sweden)

    Roxana Martínez Fernández

    2002-04-01

    Full Text Available Se desarrolló la formulación de la cefalexina 250 mg como granulado para suspensión oral. Se utilizó la vía húmeda para la preparación del granulado, teniendo en cuenta los resultados de la caracterización físico-química realizada a las materias primas empleadas. Los resultados de los análisis físico-químicos y microbiológicos del producto terminado fueron satisfactorios. Se realizó un estudio de estabilidad en vida de estante durante 18 meses, con el que se pudo comprobar que la formulación obtenida es estable durante el tiempo estudiado a temperatura entre 15 y 25 °C y durante 7 d después de reconstituido y mantenido en refrigeración. El medicamento cumple con las especificaciones de calidad descritas en la USP 24.The formulation of cephalexin 250 mg was developed as a granulate for oral suspension. The humid way was used for the preparation of the granulate, taking into account the results of the physicochemical characterization of the raw materials used. The results of the physicochemical and microbiological analyses of the finished product were satisfactory. A shelf life stability study was conducted for 18 months that made possible to prove that the formulation obtained was stable during the studied time at temperatures between 15 and 25 ºC and for 7 days after being reconstituted and kept in refrigeration. The drug meets the quality specifications described in the USP 24.

  10. Treating rheumatoid arthritis to target

    DEFF Research Database (Denmark)

    Smolen, Josef S; Aletaha, Daniel; Bijlsma, Johannes W J

    2010-01-01

    BACKGROUND: Aiming at therapeutic targets has reduced the risk of organ failure in many diseases such as diabetes or hypertension. Such targets have not been defined for rheumatoid arthritis (RA). OBJECTIVE: /st> To develop recommendations for achieving optimal therapeutic outcomes in RA. METHODS...

  11. Treating rheumatoid arthritis to target

    DEFF Research Database (Denmark)

    Smolen, Josef S; Breedveld, Ferdinand C; Burmester, Gerd R

    2016-01-01

    BACKGROUND: Reaching the therapeutic target of remission or low-disease activity has improved outcomes in patients with rheumatoid arthritis (RA) significantly. The treat-to-target recommendations, formulated in 2010, have provided a basis for implementation of a strategic approach towards this t...

  12. Saccadic adaptation to moving targets.

    Directory of Open Access Journals (Sweden)

    Katharina Havermann

    Full Text Available Saccades are so called ballistic movements which are executed without online visual feedback. After each saccade the saccadic motor plan is modified in response to post-saccadic feedback with the mechanism of saccadic adaptation. The post-saccadic feedback is provided by the retinal position of the target after the saccade. If the target moves after the saccade, gaze may follow the moving target. In that case, the eyes are controlled by the pursuit system, a system that controls smooth eye movements. Although these two systems have in the past been considered as mostly independent, recent lines of research point towards many interactions between them. We were interested in the question if saccade amplitude adaptation is induced when the target moves smoothly after the saccade. Prior studies of saccadic adaptation have considered intra-saccadic target steps as learning signals. In the present study, the intra-saccadic target step of the McLaughlin paradigm of saccadic adaptation was replaced by target movement, and a post-saccadic pursuit of the target. We found that saccadic adaptation occurred in this situation, a further indication of an interaction of the saccadic system and the pursuit system with the aim of optimized eye movements.

  13. Saccadic adaptation to moving targets.

    Science.gov (United States)

    Havermann, Katharina; Volcic, Robert; Lappe, Markus

    2012-01-01

    Saccades are so called ballistic movements which are executed without online visual feedback. After each saccade the saccadic motor plan is modified in response to post-saccadic feedback with the mechanism of saccadic adaptation. The post-saccadic feedback is provided by the retinal position of the target after the saccade. If the target moves after the saccade, gaze may follow the moving target. In that case, the eyes are controlled by the pursuit system, a system that controls smooth eye movements. Although these two systems have in the past been considered as mostly independent, recent lines of research point towards many interactions between them. We were interested in the question if saccade amplitude adaptation is induced when the target moves smoothly after the saccade. Prior studies of saccadic adaptation have considered intra-saccadic target steps as learning signals. In the present study, the intra-saccadic target step of the McLaughlin paradigm of saccadic adaptation was replaced by target movement, and a post-saccadic pursuit of the target. We found that saccadic adaptation occurred in this situation, a further indication of an interaction of the saccadic system and the pursuit system with the aim of optimized eye movements.

  14. Target recognition by wavelet transform

    CERN Document Server

    Li Zheng Dong; He Wu Liang; Pei Chun Lan; Peng Wen; SongChen; Zheng Xiao Dong

    2002-01-01

    Wavelet transform has an important character of multi-resolution power, which presents pyramid structure, and this character coincides the way by which people distinguish object from coarse to fineness and from large to tiny. In addition to it, wavelet transform benefits to reducing image noise, simplifying calculation, and embodying target image characteristic point. A method of target recognition by wavelet transform is provided

  15. ISOLDE target zone control room

    CERN Multimedia

    2016-01-01

    Operating the ISOLDE target handling robots from the dedicated control room in building 197. Monitors showing the movements of the robots (GPS in this case) in the target zone. The footage shows the actual operation by the operator as well as the different equipment such as camera electronics, camera motor controls, camera monitors and Kuka robot controls touch panel.

  16. Targeted marketing and public health.

    Science.gov (United States)

    Grier, Sonya A; Kumanyika, Shiriki

    2010-01-01

    Targeted marketing techniques, which identify consumers who share common needs or characteristics and position products or services to appeal to and reach these consumers, are now the core of all marketing and facilitate its effectiveness. However, targeted marketing, particularly of products with proven or potential adverse effects (e.g., tobacco, alcohol, entertainment violence, or unhealthful foods) to consumer segments defined as vulnerable raises complex concerns for public health. It is critical that practitioners, academics, and policy makers in marketing, public health, and other fields recognize and understand targeted marketing as a specific contextual influence on the health of children and adolescents and, for different reasons, ethnic minority populations and other populations who may benefit from public health protections. For beneficial products, such understanding can foster more socially productive targeting. For potentially harmful products, understanding the nature and scope of targeted marketing influences will support identification and implementation of corrective policies.

  17. Oxide fiber targets at ISOLDE

    DEFF Research Database (Denmark)

    Köster, U.; Bergmann, U.C.; Carminati, D.

    2003-01-01

    Many elements are rapidly released from oxide matrices. Some oxide powder targets show a fast sintering, thus losing their favorable release characteristics. Loosely packed oxide fiber targets are less critical since they may maintain their open structure even when starting to fuse together at some...... contact points. The experience with various oxide fiber targets (titania, zirconia, ceria and thoria) used in the last years at ISOLDE is reviewed. For short-lived isotopes of Cu, Ga and Xe the zirconia and ceria targets respectively provided significantly higher yields than any other target (metal foils......, oxide powders, etc.) tested before. Titania fibers, which were not commercially available, were produced in a relic process by impregnation of a rayon felt in a titanium chloride solution and subsequent calcination by heating the dried felt in air. Thoria fibers were obtained either by the same process...

  18. The Bering Target Tracking Instrumentation

    DEFF Research Database (Denmark)

    Denver, Troelz; Jørgensen, John Leif; Betto, Maurizio

    2003-01-01

    The key science instrument on the Bering satellite mission is a relative small telescope with an entrance aperture of 300 mm and a focal length between 500 and 1000 mm. The detection of potential targets is performed by one of the target scanning advanced stellar compasses (ASCs). This procedure...... results in a simple prioritized list of right ascension, declination, proper motion and intensity of each prospective target. The telescope itself has a dedicated ASC Camera Head Unit (CHU) mounted on the secondary mirror, largely co-aligned with the telescope. This CHU accurately determines the telescope......'s pointing direction. To achieve fast tracking over a large solid angle, the telescope pointing is achieved by means of a folding mirror in the optical pathway. When a prospective target approaches the telescope FOV, the ASC on the secondary will guide the folding mirror into position such that the target...

  19. High speed cryogenic monodisperse targets

    Science.gov (United States)

    Boukharov, A.; Vishnevkii, E.

    2017-11-01

    The basic possibility of creation of high speed cryogenic monodisperse targets is shown. According to calculations at input of thin liquid cryogenic jets with a velocity of bigger 100 m/s in vacuum the jets don’t manage to freeze at distance to 1 mm and can be broken into monodisperse drops. Drops due to evaporation are cooled and become granules. High speed cryogenic monodisperse targets have the following advantages: direct input in vacuum (there is no need for a chamber of a triple point chamber and sluices), it is possible to use the equipment of a cluster target, it is possible to receive targets with a diameter of D 100m/s), exact synchronization of the target hitting moment in a beam with the moment of sensors turning on.

  20. Polymer-peptide conjugates for angiogenesis targeted tumor radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Mitra, Amitava [Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201 (United States); Center for Nanomedicine and Cellular Delivery, University of Maryland, Baltimore, MD 21201 (United States); Nan, Anjan [Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201 (United States); Center for Nanomedicine and Cellular Delivery, University of Maryland, Baltimore, MD 21201 (United States); Papadimitriou, John C. [Department of Pathology, University of Maryland, Baltimore, MD 21201 (United States); Ghandehari, Hamidreza [Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201 (United States) and Center for Nanomedicine and Cellular Delivery, University of Maryland, Baltimore, MD 21201 (United States) and Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201 (United States)]. E-mail: hghandeh@rx.umaryland.edus; Line, Bruce R. [Center for Nanomedicine and Cellular Delivery, University of Maryland, Baltimore, MD 21201 (United States) and Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201 (United States) and Division of Nuclear Medicine, Department of Radiology, University of Maryland, Baltimore, MD 21201 (United States)]. E-mail: bline@umm.edu

    2006-01-15

    Introduction: New methods of delivering radiotherapy to sites of occult or disseminated cancer are needed to control the disease and address the failure of conventional therapy. Because tumor cells rely on angiogenesis for survival, we assessed the effectiveness of {beta}-emitter radiotherapy delivered by polymer-peptide conjugates that target tumor neovasculature. This molecularly targeted radiation is intended to damage both the endothelial bed and surrounding neoplastic cells. Methods: N-(2-Hydroxypropyl) methacrylamide (HPMA), a biocompatible and water-soluble copolymer, was derivatized to incorporate side chains for {sup 99m}Tc and {sup 9}Y chelation and was further conjugated to a {alpha}{sub V}{beta}{sub 3} integrin-targeting peptide (RGD4C). The HPMA copolymer-RGD4C conjugate was characterized by its side-chain contents, in vitro endothelial cell adhesion assay and its biodistribution and antitumor effectiveness in a SCID mouse xenograft model of human prostate carcinoma. Results: The conjugate contained about 16 RGD4C moieties per polymer backbone. Tumor accumulation significantly increased (P<.01) over time from 1.05{+-}0.03 % injected dose (%ID)/g tissue at 1 h to 4.32{+-}0.32% at 72 h. The activity in major normal tissues significantly decreased (P<.05) during that period. At 21 days, the control tumors increased 442% in volume from baseline. In contrast, a 7% and a 63% decrease of tumor volume were observed for the 100- and 250-{mu}Ci {sup 9}Y treatment groups, respectively. Histopathological examination revealed increased apoptosis in the treated tumors with no acute signs of radiation-induced toxicity to other organs. Conclusion: This copolymer-peptide conjugate targets tumor angiogenic vessels and delivers sufficient radiotherapy to arrest tumor growth.