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Sample records for californium 250 target

  1. Californium Electrodepositions at Oak Ridge National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Boll, Rose Ann [ORNL

    2015-01-01

    Electrodepositions of californium isotopes were successfully performed at Oak Ridge National Laboratory (ORNL) during the past year involving two different types of deposition solutions, ammonium acetate (NH4C2H3O2) and isobutanol ((CH3)2CHCH2OH). A californium product that was decay enriched in 251Cf was recovered for use in super-heavy element (SHE) research. This neutron-rich isotope, 251Cf, provides target material for SHE research for the potential discovery of heavier isotopes of Z=118. The californium material was recovered from aged 252Cf neutron sources in storage at ORNL. These sources have decayed for over 30 years, thus providing material with a very high 251Cf-to-252Cf ratio. After the source capsules were opened, the californium was purified and then electrodeposited using the isobutanol method onto thin titanium foils for use in an accelerator at the Joint Institute for Nuclear Research in Dubna, Russia. Another deposition method, ammonium acetate, was used to produce a deposition containing 1.7 0.1 Ci of 252Cf onto a stainless steel substrate. This was the largest single electrodeposition of 252Cf ever prepared. The 252Cf material was initially purified using traditional ion exchange media, such as AG50-AHIB and AG50-HCl, and further purified using a TEVA-NH4SCN system to remove any lanthanides, resulting in the recovery of 3.6 0.1 mg of purified 252Cf. The ammonium acetate deposition was run with a current of 1.0 amp, resulting in a 91.5% deposition yield. Purification and handling of the highly radioactive californium material created additional challenges in the production of these sources.

  2. Targeted therapy of renal cell carcinoma: synergistic activity of cG250-TNF and IFNg.

    NARCIS (Netherlands)

    Bauer, S.; Oosterwijk-Wakka, J.C.; Adrian, N.; Oosterwijk, E.; Fischer, E.; Wuest, T.; Stenner, F.; Perani, A.; Cohen, L.; Knuth, A.; Divgi, C.; Jager, D.; Scott, A.M.; Ritter, G.; Old, L.J.; Renner, C.

    2009-01-01

    Immunotherapeutic targeting of G250/Carbonic anhydrase IX (CA-IX) represents a promising strategy for treatment of renal cell carcinoma (RCC). The well characterized human-mouse chimeric G250 (cG250) antibody has been shown in human studies to specifically enrich in CA-IX positive tumors and was cho

  3. Historical Review of Californium-252 Discovery and Development

    Science.gov (United States)

    Stoddard, D. H.

    1985-01-01

    This paper discusses the discovery and history of californium 252. This isotope may be synthesized by irradiating plutonium 239, plutonium 242, americium 243, or curium 244 with neutrons in a nuclear reactor. Various experiments and inventions involving Cf conducted at the Savannah River Plant are discussed. The evolution of radiotherapy using californium 252 is reviewed. (PLG)

  4. Spallation yield of neutrons produced in thick lead target bombarded with 250 MeV protons

    Science.gov (United States)

    Chen, L.; Ma, F.; Zhanga, X. Y.; Ju, Y. Q.; Zhang, H. B.; Ge, H. L.; Wang, J. G.; Zhou, B.; Li, Y. Y.; Xu, X. W.; Luo, P.; Yang, L.; Zhang, Y. B.; Li, J. Y.; Xu, J. K.; Liang, T. J.; Wang, S. L.; Yang, Y. W.; Gu, L.

    2015-01-01

    The neutron yield from thick target of Pb irradiated with 250 MeV protons has been studied experimentally. The neutron production was measured with the water-bath gold method. The thermal neutron distributions in the water were determined according to the measured activities of Au foils. Corresponding results calculated with the Monte Carlo code MCNPX were compared with the experimental data. It was found out that the Au foils with cadmium cover significantly changed the spacial distribution of the thermal neutron field. The corrected neutron yield was deduced to be 2.23 ± 0.19 n/proton by considering the influence of the Cd cover on the thermal neutron flux.

  5. Spallation yield of neutrons produced in thick lead target bombarded with 250 MeV protons

    Energy Technology Data Exchange (ETDEWEB)

    Chen, L. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Ma, F., E-mail: mf@impcas.ac.cn [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Zhanga, X.Y.; Ju, Y.Q.; Zhang, H.B.; Ge, H.L.; Wang, J.G. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Zhou, B. [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Li, Y.Y.; Xu, X.W. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Luo, P.; Yang, L.; Zhang, Y.B.; Li, J.Y.; Xu, J.K. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Liang, T.J. [Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China); Wang, S.L. [University of Chinese Academy of Sciences, Beijing 100049 (China); Yang, Y.W.; Gu, L. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China)

    2015-01-01

    The neutron yield from thick target of Pb irradiated with 250 MeV protons has been studied experimentally. The neutron production was measured with the water-bath gold method. The thermal neutron distributions in the water were determined according to the measured activities of Au foils. Corresponding results calculated with the Monte Carlo code MCNPX were compared with the experimental data. It was found out that the Au foils with cadmium cover significantly changed the spacial distribution of the thermal neutron field. The corrected neutron yield was deduced to be 2.23±0.19 n/proton by considering the influence of the Cd cover on the thermal neutron flux.

  6. Spontaneous Partitioning of Californium from Curium: Curious Cases from the Crystallization of Curium Coordination Complexes

    Energy Technology Data Exchange (ETDEWEB)

    Cary, Samantha K.; Silver, Mark A.; Liu, Guokui; Wang, Jamie C.; Bogart, Justin A.; Stritzinger, Jared T.; Arico, Alexandra A.; Hanson, Kenneth; Schelter, Eric J.; Albrecht-Schmitt, Thomas E.

    2015-12-07

    The reaction of 248CmCl3 with excess 2,6-pyridinedicarboxylic acid (DPA) under mild solvothermal conditions results in crystallization of the tris-chelate complex Cm(HDPA)3·H2O. Approximately half of the curium remains in solution at the end of this process, and evaporation of the mother liquor results in crystallization of the bis-chelate complex [Cm(HDPA)- (H2DPA)(H2O)2Cl]Cl·2H2O. 248Cm is the daughter of the α decay of 252Cf and is extracted in high purity from this parent. However, trace amounts of 249,250,251Cf are still present in all samples of 248Cm. During the crystallization of Cm(HDPA)3·H2O and [Cm(HDPA)(H2DPA)(H2O)2Cl]Cl·2H2O, californium(III) spontaneously separates itself from the curium complexes and is found doped within crystals of DPA in the form of Cf(HDPA)3. These results add to the growing body of evidence that the chemistry of californium is fundamentally different from that of earlier actinides.

  7. The study of neutron spectra in water bath from Pb target irradiated by 250MeV/u protons

    CERN Document Server

    Li, Yanyan; Ju, Yongqin; Ma, Fei; Zhang, Hongbin; Chen, Liang; Ge, Honglin; Luo, Peng; Zhou, Bin; Zhang, Yanbin; Li, Jianyang; Xu, Junkui; Wang, Songlin; Yang, Yongwei; Yang, Lei

    2014-01-01

    The spallation neutrons were produced by the irradiation of Pb with 250 MeV protons. The Pb target was surrounded by water which was used to slow down the emitted neutrons. The moderated neutrons in the water bath were measured by using the resonance detectors of Au, Mn and In with Cd cover. According to the measured activities of the foils, the neutron flux at different resonance energy were deduced and the epithermal neutron spectra were proposed. Corresponding results calculated with the Monte Carlo code MCNPX were compared with the experimental data to check the validity of the code.

  8. Shielding variation effects for 250 MeV protons on tissue targets.

    Science.gov (United States)

    Brandl, A; Hranitzky, C; Rollet, S

    2005-01-01

    This paper provides results of computer simulation studies with the goal to analyse issues regarding radiation protection for personnel, patients and third persons involved in hadron therapy treatment. The treatment room and the patient are modelled by simple cylindrical geometries at incident proton energies of 250 MeV. Monte Carlo simulations of the energy and angular dependence of proton, neutron and photon radiation fields and resulting ambient dose equivalent distributions outside the shielding walls are performed. In order to investigate systematic uncertainties due to the shielding materials and inherent to the computer models, various concrete compositions, densities and water contents are modelled, and the influence of simulation parameters on the results obtained is determined. Generally, good agreement is found between results provided by MCNPX and FLUKA computer codes. Variations in neutron ambient dose attenuation from -50 to +/-30% are found due to varying concrete composition. Changes in the water content of the concrete in the order of 8% may cause variations up to 20%.

  9. Production, Distribution, and Applications of Californium-252 Neutron Sources

    Energy Technology Data Exchange (ETDEWEB)

    Balo, P.A.; Knauer, J.B.; Martin, R.C.

    1999-10-03

    The radioisotope {sup 252}Cf is routinely encapsulated into compact, portable, intense neutron sources with a 2.6-year half-life. A source the size of a person's little finger can emit up to 10{sup 11} neutrons/s. Californium-252 is used commercially as a reliable, cost-effective neutron source for prompt gamma neutron activation analysis (PGNAA) of coal, cement, and minerals, as well as for detection and identification of explosives, laud mines, and unexploded military ordnance. Other uses are neutron radiography, nuclear waste assays, reactor start-up sources, calibration standards, and cancer therapy. The inherent safety of source encapsulations is demonstrated by 30 years of experience and by U.S. Bureau of Mines tests of source survivability during explosions. The production and distribution center for the U. S Department of Energy (DOE) Californium Program is the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory (ORNL). DOE sells The radioisotope {sup 252}Cf is routinely encapsulated into compact, portable, intense neutron sources with a 2.6- year half-life. A source the size of a person's little finger can emit up to 10 neutrons/s. Californium-252 is used commercially as a reliable, cost-effective neutron source for prompt gamma neutron activation analysis (PGNAA) of coal, cement, and minerals, as well as for detection and identification of explosives, laud mines, and unexploded military ordnance. Other uses are neutron radiography, nuclear waste assays, reactor start-up sources, calibration standards, and cancer therapy. The inherent safety of source encapsulations is demonstrated by 30 years of experience and by U.S. Bureau of Mines tests of source survivability during explosions. The production and distribution center for the U. S Department of Energy (DOE) Californium Program is the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory(ORNL). DOE sells {sup 252}Cf to commercial

  10. Study of neutron spectra in a water bath from a Pb target irradiated by 250 MeV protons

    Science.gov (United States)

    Li, Yan-Yan; Zhang, Xue-Ying; Ju, Yong-Qin; Ma, Fei; Zhang, Hong-Bin; Chen, Liang; Ge, Hong-Lin; Wan, Bo; Luo, Peng; Zhou, Bin; Zhang, Yan-Bin; Li, Jian-Yang; Xu, Jun-Kui; Wang, Song-Lin; Yang, Yong-Wei; Yang, Lei

    2015-04-01

    Spallation neutrons were produced by the irradiation of Pb with 250 MeV protons. The Pb target was surrounded by water which was used to slow down the emitted neutrons. The moderated neutrons in the water bath were measured by using the resonance detectors of Au, Mn and In with a cadmium (Cd) cover. According to the measured activities of the foils, the neutron flux at different resonance energies were deduced and the epithermal neutron spectra were proposed. Corresponding results calculated with the Monte Carlo code MCNPX were compared with the experimental data to check the validity of the code. The comparison showed that the simulation could give a good prediction for the neutron spectra above 50 eV, while the finite thickness of the foils greatly effected the experimental data in low energy. It was also found that the resonance detectors themselves had great impact on the simulated energy spectra. Supported by National Natural Science Foundation and Strategic Priority Research Program of the Chinese Academy of Sciences (11305229, 11105186, 91226107, 91026009, XDA03030300)

  11. Teratogenic effect of Californium-252 irradiation in rats

    Energy Technology Data Exchange (ETDEWEB)

    Satow, Yukio; Lee, Juing-Yi; Hori, Hiroshi; Okuda, Hiroe; Tsuchimoto, Shigeo; Sawada, Shozo; Yokoro, Kenjiro (Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology)

    1989-06-01

    The teratogenicity of Californium-252 (Cf-252) irradiation which generates approximately 70% 2.3 MeV fast neutron and 30% gamma rays was evaluated. A single whole body exposure of Cf-252 at various doses was given to pregnant rats on day 8 or 9 of pregnancy, followed by microscopic autopsy of the fetuses at the terminal stage of pregnancy to search for external and internal malformations. For comparison, pregnant rats were irradiated with various doses of Cobalt-60 (Co-60) standard gamma rays at the same dose rate (1 rad/min.). The doses were 20-120 rad of Cf-252 and 80-220 rad of Co-60. Using frequency of radiation induced malformations observed on day 8 of pregnancy as an index, relative biological effectiveness (RBE) of 2.3-2.7 was obtained from the straight line obtained by modifying by the least squares method the frequency curves of malformed fetuses in total implants and in surviving fetuses. The types of malformations induced by Cf-252 and Co-60 irradiation were alike. Using fetal LD/sub 50/ as an index, 2.4 was obtained as RBE when irradiated on day 8 of pregnancy and 3.1 as that when irradiated on day 9. The results showed that Cf-252 had stronger a teratogenic effect than Co-60 gamma rays. (author).

  12. Secondary particle yields from 400 MeV/u carbon ion and 250 MeV proton beams incident on thick targets

    Energy Technology Data Exchange (ETDEWEB)

    Ferrari, A. [Fondazione CNAO, Centro Nazionale di Adroterapia Oncologica, strada Campeggi, 27100 Pavia (Italy); Ferrarini, M., E-mail: michele.ferrarini@polimi.it [Fondazione CNAO, Centro Nazionale di Adroterapia Oncologica, strada Campeggi, 27100 Pavia (Italy); Politecnico di Milano, Dipartimento di Energia, Via Ponzio 34/3, 20133 Milano (Italy); Pelliccioni, M. [Fondazione CNAO, Centro Nazionale di Adroterapia Oncologica, strada Campeggi, 27100 Pavia (Italy); INFN, Laboratori Nazionali di Frascati, Via E. Fermi 40, 00044 Frascati (Italy)

    2011-07-01

    The double differential particle yield produced by hadron beams striking thick targets of copper, tungsten and ICRU tissue, have been determined by means of the Monte Carlo transport code FLUKA (version FLUKA 2008.3b.1). 400 MeV/u carbon ion and 250 MeV proton pencil beams have been considered. Secondary neutrons, photons, and protons have been scored. In order to validate the obtained data, a few simulations have been also repeated with MCNPX 2.6.0. The calculated results are presented and compared with the experimental data reported in literature. They should be very useful to solve a number of problems related to technological aspects of hadrontherapy.

  13. Discovery of abundant cellulose microfibers encased in 250 Ma Permian halite: a macromolecular target in the search for life on other planets.

    Science.gov (United States)

    Griffith, Jack D; Willcox, Smaranda; Powers, Dennis W; Nelson, Roger; Baxter, Bonnie K

    2008-04-01

    In this study, we utilized transmission electron microscopy to examine the contents of fluid inclusions in halite (NaCl) and solid halite crystals collected 650 m below the surface from the Late Permian Salado Formation in southeastern New Mexico (USA). The halite has been isolated from contaminating groundwater since deposition approximately 250 Ma ago. We show that abundant cellulose microfibers are present in the halite and appear remarkably intact. The cellulose is in the form of 5 nm microfibers as well as composite ropes and mats, and was identified by resistance to 0.5 N NaOH treatment and susceptibility to cellulase enzyme treatment. These cellulose microfibers represent the oldest native biological macromolecules to have been directly isolated, examined biochemically, and visualized (without growth or replication) to date. This discovery points to cellulose as an ideal macromolecular target in the search for life on other planets in our Solar System.

  14. Apparatus for the measurement of total body nitrogen using prompt neutron activation analysis with californium-252.

    Science.gov (United States)

    Mackie, A; Hannan, W J; Smith, M A; Tothill, P

    1988-01-01

    Details of clinical apparatus designed for the measurement of total body nitrogen (as an indicator of body protein), suitable for the critically ill, intensive-care patient are presented. Californium-252 radio-isotopic neutron sources are used, enabling a nitrogen measurement by prompt neutron activation analysis to be made in 40 min with a precision of +/- 3.2% for a whole body dose equivalent of 0.145 mSv. The advantages of Californium-252 over alternative neutron sources are discussed. A comparison between two irradiation/detection geometries is made, leading to an explanation of the geometry adopted for the apparatus. The choice of construction and shielding materials to reduce the count rate at the detectors and consequently to reduce the pile-up contribution to the nitrogen background is discussed. Salient features of the gamma ray spectroscopy system to reduce spectral distortion from pulse pile-up are presented.

  15. ACT250 Districts

    Data.gov (United States)

    Vermont Center for Geographic Information — The ACT 250 Districts layer is part of a larger dataset that contains administrative boundaries for Vermont's Agency of Natural Resources. The dataset includes...

  16. Clinical Report on Californium-252 Neutron Intraluminal Brachytherapy Combined with External Irradiation for Cervical Carcinoma Treatment

    Institute of Scientific and Technical Information of China (English)

    Huanyu Zhao; Keming Wang; Jian Sun; Xin Geng; Weiming Zhang

    2006-01-01

    OBJECTIVE To observe the curative effects and complications of californium-252 (252Cf) neutron intraluminal brachytherapy (IBT) combined with external irradiation (El) for treatment of cervical carcinoma.METHODS From December 2000 to December 2004, 128 cases of cervical carcinoma staged into ⅡA~ⅢB according to the International Federation of Gynecology and Obstetrics (FIGO) standards were treated with 252Cf neutron IBT using 8~10 Gy per fraction, once a week. The total dose at reference A point was 36~40 Gy in 4~5 fractions. From the second day after 252Cf neutron IBT treatment, the whole pelvic cavity was treated with 60Co γ-ray El, applying 2 Gy per fraction, 4 times per week. After 20~25 Gy of El, the center of the whole pelvic field was blocked with 4 cm of lead in width. The total dose of El was 45~50 Gy.RESULTS The short-term therapeutic effects were CR 95.3% and PR 4.7%. The 3 and 5-year local control rates were 93.5% and 87.9%. The overall 3-year survival rate was 87.5% and for Stages Ⅱ and Ⅲ , 90.9%and 81.5% respectively; the overall 5-year survival rate was 70% and for Stages Ⅱ and Ⅲ, 76.2% and 61% respectively. The rate of radiation complications was 4.7% for radiation cystitis, 7.8% for radiation proctitis, 6.3%for vagina contracture and adhesion and 5.5% for protracted radiation proctitis.CONCLUSION An combination of 252Cf neutron IBT with El for treatment of cervical carcinoma can be well-tolerated by cervical carcinoma patients. The rate of local tumor control is high and radiation complications are few.

  17. Application of TSH bioindicator for studying the biological efficiency of neutrons from californium-252 source

    Energy Technology Data Exchange (ETDEWEB)

    Cebulska-Wasilewska, A.; Rekas, K. [Institute of Nuclear Physics, Cracow (Poland); Kim, J.K. [Korea Atomic Energy Research Inst., Taejon (Korea, Republic of)

    1997-12-31

    The effectiveness of neutrons from a Californium-252 source in the induction of various abnormalities in the Tradescantia clone 4430 stamen hair cells (TSH-assay) was studied. The special attention was paid to check whether any enhancement in effects caused by process of boron neutron capture is visible in the cells enriched with boron ions. Two chemicals (borax and BSH) were applied to introduce boron-10 ions into cells. Inflorescence, normal or pretreated with chemicals containing boron, were irradiated in the air with neutrons from a Cf-252 source at KAERI, Taejon, Korea. To estimate the relative biological effectiveness (RBE) in the induction of gene mutations of the neutron beam under the study, Tradescantia inflorescences, without any chemical pretreatment, were irradiated with various doses of X-rays. The ranges of radiation doses used were 0-0.1 Gy in neutrons and 0-0.5 Gy in X-rays. After the time needed to complete the postirradiation repair Tradescantia cuttings were transferred to Cracow, where screening of gene and lethal; mutations, cell cycle alterations in somatic cells have been done, and dose response relationships were figured. The maximal RBE values were estimated in the range of 4.6-6.8. Alterations of RBE value were observed; from 6.8 to 7.8 in the case of plants pretreated with 240 ppm of B-10 from borax, and 4.6 to 6.1 in the case of 400 ppm of B-10 from BSH. Results showed a slight, although statistically insignificant increase in biological efficacy of radiation from the Cf-252 source in samples pretreated with boron containing chemicals. (author)

  18. Study of the shielding for spontaneous fission sources of Californium-252; Estudio de blindaje para fuentes de fision espontanea de Californio-252

    Energy Technology Data Exchange (ETDEWEB)

    Davila R, I

    1991-06-15

    A shielding study is made to attenuate, until maximum permissible levels, the neutrons radiation and photons emitted by spontaneous fission coming from a source of Californium-252. The compound package by a database (Library DLC-23) and the ANISNW code is used, in it version for personal computer. (Author)

  19. From ANAIS-25 towards ANAIS-250

    CERN Document Server

    Amaré, J; Cuesta, C; García, E; Ginestra, C; Martínez, M; Oliván, M A; Ortigoza, Y; de Solórzano, A Ortiz; Pobes, C; Puimedón, J; Sarsa, M L; Villar, J A; Villar, P

    2014-01-01

    The ANAIS (Annual modulation with NaI(Tl) Scintillators) experiment aims at the confirmation of the DAMA/LIBRA signal using the same target and technique at the Canfranc Underground Laboratory (LSC). 250 kg of ultra pure NaI(Tl) crystals will be used as target, divided into 20 modules, 12.5 kg mass each, and coupled to two high e?ciency photomultiplier tubes from Hamamatsu. The ANAIS-25 set-up at the LSC consists of two prototypes, amounting 25 kg NaI(Tl), grown from a powder having a potassium level under the limit of our analytical techniques, and installed in a convenient shielding at the LSC. The background has been carefully analyzed and main results will be summarized in this paper, focusing on the alpha contamination identified in the prototypes and the related background contributions. Status of fulfillment of ANAIS experimental goals and prospects for the building of ANAIS-250 experiment will be also revised.

  20. Long-term effects of an intracavitary treatment with californium-252 on normal tissue. [Swine, /sup 226/Ra

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, M.F.; Beamer, J.L.; Mahony, T.D.; Cross, F.T.; Lund, J.E.; Endres, G.W.R.

    1976-01-01

    About one hundred fifty swine were exposed to either radium-226 or californium-252 sources in the uterine cervix to determine an RBE for both acute and long-term effects. That value for early changes in the tissues at risk in the treatment of cervical cancer was between 6.2 and 6.8. The incidence of complications increased with time after exposure, especially among animals treated with /sup 252/Cf. Analysis of rectal injury showed that ulceration occurred frequently within a year postexposure at doses between 1600 and 2400 rad calculated at 2 cm lateral to the source midline. Fat necrosis and smooth muscle atrophy, resulting in a local rectal stricture, were delayed changes observed in some animals. The lower ureter was the site for a greater frequency of complications than the GI tract. Ureteral stricture often occurred at doses of 1200 rad from /sup 252/Cf and 7000 rad from /sup 226/Ra. Observation of delayed effects in the uterine-cervix in animals held up to 4 years postexposure indicate that the RBE for /sup 252/Cf may be increased to a value as high as 18, while repair may have even decreased it to about 5.6 in the rectum. Fifty swine are still being observed for long-term effects after doses above 800 rad from /sup 252/Cf and 5000 rad from /sup 226/Ra.

  1. Development of electron beam ion source charge breeder for rare isotopes at Californium Rare Isotope Breeder Upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Kondrashev, S.; Dickerson, C.; Levand, A.; Ostroumov, P. N.; Pardo, R. C.; Savard, G.; Vondrasek, R. [Physics Division, Argonne National Laboratory, Argonne, Illinois 60439 (United States); Alessi, J.; Beebe, E.; Pikin, A. [Collider-Accelerator Department, Brookhaven National Laboratory, Upton, New York 11973 (United States); Kuznetsov, G. I.; Batazova, M. A. [Budker Institute of Nuclear Physics, Novosibirsk 630090 (Russian Federation)

    2012-02-15

    Recently, the Californium Rare Isotope Breeder Upgrade (CARIBU) to the Argonne Tandem Linac Accelerator System (ATLAS) was commissioned and became available for production of rare isotopes. Currently, an electron cyclotron resonance ion source is used as a charge breeder for CARIBU beams. To further increase the intensity and improve the purity of neutron-rich ion beams accelerated by ATLAS, we are developing a high-efficiency charge breeder for CARIBU based on an electron beam ion source (EBIS). The CARIBU EBIS charge breeder will utilize the state-of-the-art EBIS technology recently developed at Brookhaven National Laboratory (BNL). The electron beam current density in the CARIBU EBIS trap will be significantly higher than that in existing operational charge-state breeders based on the EBIS concept. The design of the CARIBU EBIS charge breeder is nearly complete. Long-lead components of the EBIS such as a 6-T superconducting solenoid and an electron gun have been ordered with the delivery schedule in the fall of 2011. Measurements of expected breeding efficiency using the BNL Test EBIS have been performed using a Cs{sup +} surface ionization ion source for external injection in pulsed mode. In these experiments we have achieved {approx}70% injection/extraction efficiency and breeding efficiency into the most abundant charge state of {approx}17%.

  2. Development of electron beam ion source charge breeder for rare isotopes at Californium Rare Isotope Breeder Upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Kondrashev S.; Alessi J.; Dickerson, C.; Levand, A.; Ostroumov, P.N.; Pardo, R.C.; Savard, G.; Vondrasek, R.; Beebe, E.; Pikin, A.; Kuznetsov, G.I.; Batazova, M.A.

    2012-02-03

    Recently, the Californium Rare Isotope Breeder Upgrade (CARIBU) to the Argonne Tandem Linac Accelerator System (ATLAS) was commissioned and became available for production of rare isotopes. Currently, an electron cyclotron resonance ion source is used as a charge breeder for CARIBU beams. To further increase the intensity and improve the purity of neutron-rich ion beams accelerated by ATLAS, we are developing a high-efficiency charge breeder for CARIBU based on an electron beam ion source (EBIS). The CARIBU EBIS charge breeder will utilize the state-of-the-art EBIS technology recently developed at Brookhaven National Laboratory (BNL). The electron beam current density in the CARIBU EBIS trap will be significantly higher than that in existing operational charge-state breeders based on the EBIS concept. The design of the CARIBU EBIS charge breeder is nearly complete. Long-lead components of the EBIS such as a 6-T superconducting solenoid and an electron gun have been ordered with the delivery schedule in the fall of 2011. Measurements of expected breeding efficiency using the BNL Test EBIS have been performed using a Cs{sup +} surface ionization ion source for external injection in pulsed mode. In these experiments we have achieved {approx}70% injection/extraction efficiency and breeding efficiency into the most abundant charge state of {approx}17%.

  3. 48 CFR 1846.673 - Distribution of DD Forms 250 and 250c.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Distribution of DD Forms... Reports 1846.673 Distribution of DD Forms 250 and 250c. (a) DD Forms 250 and 250c shall be distributed in accordance with installation procedures. (b) The contractor is responsible for distributing DD Forms 250...

  4. 32 CFR 250.6 - Responsibilities.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 250.6 Section 250.6 National... WITHHOLDING OF UNCLASSIFIED TECHNICAL DATA FROM PUBLIC DISCLOSURE § 250.6 Responsibilities. (a) The Under Secretary of Defense for Research and Engineering (USDR&E) shall have overall responsibility for...

  5. 30 CFR 250.1614 - Mud program.

    Science.gov (United States)

    2010-07-01

    ... OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1614 Mud program. (a) The quantities, characteristics, use, and testing of drilling mud and the related drilling procedures shall be designed and... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Mud program. 250.1614 Section 250.1614...

  6. 30 CFR 250.1633 - Production measurement.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Production measurement. 250.1633 Section 250... SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1633 Production measurement. (a) General. Measurement equipment and security procedures shall be designed, installed, used, maintained,...

  7. 21 CFR 73.250 - Fruit juice.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Fruit juice. 73.250 Section 73.250 Food and Drugs... ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.250 Fruit juice. (a) Identity. (1) The color additive fruit juice is prepared either by expressing the juice from mature varieties of fresh, edible fruits, or...

  8. 30 CFR 250.604 - Hydrogen sulfide.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Hydrogen sulfide. 250.604 Section 250.604... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Workover Operations § 250.604 Hydrogen sulfide. When a well-workover operation is conducted in zones known to contain hydrogen sulfide (H2S) or...

  9. 30 CFR 250.504 - Hydrogen sulfide.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Hydrogen sulfide. 250.504 Section 250.504... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Completion Operations § 250.504 Hydrogen sulfide. When a well-completion operation is conducted in zones known to contain hydrogen sulfide (H2S) or...

  10. 30 CFR 250.808 - Hydrogen sulfide.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Hydrogen sulfide. 250.808 Section 250.808... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Production Safety Systems § 250.808 Hydrogen sulfide. Production operations in zones known to contain hydrogen sulfide (H2S) or in zones where the presence of...

  11. 7 CFR 250.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Administration. 250.2 Section 250.2 Agriculture... TERRITORIES AND POSSESSIONS AND AREAS UNDER ITS JURISDICTION General § 250.2 Administration. (a) Delegation to FNS. Within the Department, FNS shall act on behalf of the Department in the administration of...

  12. 48 CFR 1846.672 - Preparing DD Forms 250 and 250c.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Preparing DD Forms 250 and 250c. 1846.672 Section 1846.672 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... DD Forms 250 and 250c....

  13. 36 CFR 2.50 - Special events.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Special events. 2.50 Section... PROTECTION, PUBLIC USE AND RECREATION § 2.50 Special events. (a) Sports events, pageants, regattas, public spectator attractions, entertainments, ceremonies, and similar events are allowed: Provided, however,...

  14. 7 CFR 250.15 - Financial management.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Financial management. 250.15 Section 250.15 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... Financial management. (a) Distribution charges. (1) Recipient agencies may be required to pay part or all...

  15. 40 CFR 35.250 - Purpose.

    Science.gov (United States)

    2010-07-01

    ... ASSISTANCE Environmental Program Grants Pesticide Program Implementation (section 23(a)(1)) § 35.250 Purpose. (a) Purpose of section. Sections 35.250 through 35.259 govern Pesticide Program Implementation Cooperative Agreements to States (as defined in section 2 of Federal Insecticide, Fungicide, and...

  16. 30 CFR 250.1203 - Gas measurement.

    Science.gov (United States)

    2010-07-01

    ... CFR 250.198. (3) Ensure that the measurement components demonstrate consistent levels of accuracy... recorder is used, you must follow the recommendations in API MPMS as referenced in 30 CFR 250.198. (5) Take.... 1713 and 30 CFR part 212. (5) Upon the request of the Regional Supervisor, you must provide copies...

  17. 7 CFR 250.67 - Charitable institutions.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Charitable institutions. 250.67 Section 250.67... Charitable institutions. (a) Distribution to charitable institutions. The Department provides donated foods to distributing agencies for distribution to charitable institutions, as defined in this part....

  18. 7 CFR 250.21 - Civil rights.

    Science.gov (United States)

    2010-01-01

    ... rights. Distributing agencies, subdistributing agencies and recipient agencies shall comply with the Department's nondiscrimination regulations (7 CFR parts 15, 15a, and 15b) and the FNS civil rights... 7 Agriculture 4 2010-01-01 2010-01-01 false Civil rights. 250.21 Section 250.21...

  19. Dicty_cDB: SLI250 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLI250 (Link to dictyBase) - - - Contig-U16436-1 SLI250Z (Link... to Original site) - - SLI250Z 578 - - - - Show SLI250 Library SL (Link to library) Clone ID SLI250 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLI2-C/SLI250Q.Seq.d/ Representative seq. ID SLI25...0Z (Link to Original site) Representative DNA sequence >SLI250 (SLI250Q) /CSM/SL/SLI2-C/SLI250Q.Seq.d/ XXXXX....d/ 1043 0.0 VHG138 (VHG138Q) /CSM/VH/VHG1-B/VHG138Q.Seq.d/ 1043 0.0 SLI250 (SLI250Q) /CSM/SL/SLI2-C/SLI250Q

  20. Dicty_cDB: CHR250 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHR250 (Link to dictyBase) - - - Contig-U15776-1 CHR250P (Link to Original site) CHR...250F 618 CHR250Z 748 CHR250P 1346 - - Show CHR250 Library CH (Link to library) Clone ID CHR...e URL http://dictycdb.biol.tsukuba.ac.jp/CSM/CH/CHR2-C/CHR250Q.Seq.d/ Representative seq. ID CHR...250P (Link to Original site) Representative DNA sequence >CHR250 (CHR250Q) /CSM/CH/CHR2-C/CHR...ences producing significant alignments: (bits) Value CHR250 (CHR250Q) /CSM/CH/CHR2-C/CHR250Q.Seq.d/ 2432 0.0

  1. Dicty_cDB: SFF250 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SF (Link to library) SFF250 (Link to dictyBase) - - - - SFF250P (Link to Original site) SFF250F 550 SF...F250Z 636 SFF250P 1186 - - Show SFF250 Library SF (Link to library) Clone ID SFF250 (Link... to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig - Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SF/SF...F2-C/SFF250Q.Seq.d/ Representative seq. ID SFF250P (Link to... Original site) Representative DNA sequence >SFF250 (SFF250Q) /CSM/SF/SFF2-C/SFF250Q.Seq.d/ TTATCTCTCAATTNAA

  2. 7 CFR 250.53 - Contract provisions.

    Science.gov (United States)

    2010-01-01

    ... GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION DONATION OF FOODS FOR USE IN THE UNITED STATES, ITS... Management Companies § 250.53 Contract provisions. (a) Required contract provisions in fixed-price contracts... recipient agency's fixed-price contract with a food service management company. Such provisions must also...

  3. 30 CFR 250.490 - Hydrogen sulfide.

    Science.gov (United States)

    2010-07-01

    ... been confirmed. Well-control fluid means drilling mud and completion or workover fluid as appropriate... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Hydrogen Sulfide § 250.490 Hydrogen... section when conducting drilling, well-completion/well-workover, and production operations in zones...

  4. 30 CFR 250.1613 - Diverter systems.

    Science.gov (United States)

    2010-07-01

    ... OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1613 Diverter systems. (a) When drilling a conductor or cap rock hole, all drilling units shall be equipped with a diverter system consisting of a..., installed, and maintained so as to divert gases, water, mud, and other materials away from the...

  5. 41 CFR 60-250.21 - Prohibitions.

    Science.gov (United States)

    2010-07-01

    ... with a disability that impairs sensory, manual, or speaking skills, the test results accurately reflect... Discrimination Prohibited § 60-250.21 Prohibitions. The term “discrimination” includes, but is not limited to... other protected veteran to the discrimination prohibited by this part. (2) Contractual or...

  6. 40 CFR 264.250 - Applicability.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Waste Piles § 264.250... treat hazardous waste in piles, except as § 264.1 provides otherwise. (b) The regulations in...

  7. 5 CFR 250.301 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... leave. Team leaders are those who provide employees with day-to-day guidance in work projects, but do... AGENCIES Employee Surveys § 250.301 Definitions. In this part— Agency means an executive agency as defined... agency's management team. This includes anyone with supervisory or managerial duties. Managers are...

  8. Johann Wilhelm Krause 250 / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    2007-01-01

    Eesti klassitsistliku arhitektuuri suurkuju ning Tartu Ülikooli arhitekti Johann Wilhelm Krause 250. sünniaastapäeva tähistati näitustega Tallinnas ja Tartus. Tartu Ülikooli raamatukogu kunstikogusse kuulub ligi 700 J. W. Krause loodud joonistust

  9. 30 CFR 250.125 - Service fees.

    Science.gov (United States)

    2010-07-01

    ...—Fixed Structure Under the Platform Approval Program $3,018 § 250.905(k). (18) Platform Application... amended application. (c) Verbal approvals are occasionally given in special circumstances. Any action that will be considered a verbal permit approval requires either a paper permit application to follow...

  10. 7 CFR 250.57 - Commodity schools.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION DONATION OF FOODS FOR USE IN THE UNITED STATES, ITS... Child Nutrition Programs § 250.57 Commodity schools. (a) Categorization of commodity schools....

  11. IceMap250—Automatic 250 m Sea Ice Extent Mapping Using MODIS Data

    Directory of Open Access Journals (Sweden)

    Charles Gignac

    2017-01-01

    Full Text Available The sea ice cover in the North evolves at a rapid rate. To adequately monitor this evolution, tools with high temporal and spatial resolution are needed. This paper presents IceMap250, an automatic sea ice extent mapping algorithm using MODIS reflective/emissive bands. Hybrid cloud-masking using both the MOD35 mask and a visibility mask, combined with downscaling of Bands 3–7 to 250 m, are utilized to delineate sea ice extent using a decision tree approach. IceMap250 was tested on scenes from the freeze-up, stable cover, and melt seasons in the Hudson Bay complex, in Northeastern Canada. IceMap250 first product is a daily composite sea ice presence map at 250 m. Validation based on comparisons with photo-interpreted ground-truth show the ability of the algorithm to achieve high classification accuracy, with kappa values systematically over 90%. IceMap250 second product is a weekly clear sky map that provides a synthesis of 7 days of daily composite maps. This map, produced using a majority filter, makes the sea ice presence map even more accurate by filtering out the effects of isolated classification errors. The synthesis maps show spatial consistency through time when compared to passive microwave and national ice services maps.

  12. FRISC-E; A 250-MIPS hybrid microprocessor

    Energy Technology Data Exchange (ETDEWEB)

    Greub, H.J. (Rensselaer Polytechnic Inst., Troy, NY (USA). Center for Integrated Electronics); McDonald, J.F. (Rensselaer Polytechnic Inst., Troy, NY (USA). Dept. of Electrical, Computer, and Systems Engineering); Creedon, T.G. (Tektronix, Inc., Beaverton, OR (USA))

    1990-05-01

    Implementing the principles of reduced instruction set computers (RISC) with advanced high-speed circuit technology is both attractive and difficult. Advanced bipolar circuit technology, for instance, offers gate delays as low as 55 ps but dissipates considerable power. Therefore, a high-speed microprocessor fabricated with this technology must be partitioned into LSI circuits to increase yield and reduce heat flux. But partitioning requires die-to-die interconnections, which cause signal propagation delays. The authors discuss how the FRISC series of fast reduced instruction set computer designs goes a long way towards solving these problems. For FRISC-E the targeted instruction rate of 250 MIPS led to a seven-stage instruction pipeline. The authors have partitioned the processor into 11 chips.

  13. Dicty_cDB: SSI250 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 250Z (Link to Original site) - - SSI250Z 697 - - - - Show SSI250 Library SS (Link to library) Clone ID SSI...Representative seq. ID SSI250Z (Link to Original site) Representative DNA sequence >SSI250 (SSI250Q) /CSM/SS/SSI2-C/SSI...I*inpyqnfytgnq Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SSI...SS (Link to library) SSI250 (Link to dictyBase) - G00812 DDB0231535 Contig-U05055-1 SSI...250 (Link to dictyBase) Atlas ID - NBRP ID G00812 dictyBase ID DDB0231535 Link to Contig Contig-U05055-1 Original si

  14. [Ombrelle 250: a new contraceptive intrauterine device].

    Science.gov (United States)

    Audebert, A J

    1986-10-01

    The umbrella 250 is a new IUD developed in France to minimize rigidity and penetration of the uterine wall so as to lessen side effects of local pain and bleeding. The flexible, supple vactor has the characteristics of a spring to ensure that it remains in place in the fundal position required for efficacy. The device is in the shape of a T whose vertical branch is coated with copper threads containing 250 sq mm of copper. The umbrella 250 comes in 1 size, 31.5 mm long, and is adaptable to any uterine cavity. The cumulative rates of events per 100 women after 12, 24, and 36 months respectively were .2, .9, and .9 for pregnancy; .6, .6, and .6 for expulsion; 1.9, 3.7, and 4.0 for removal for pain or bleeding; .8, 1.7, and 2.8 for removal for other medical reason; 1.7, 5.7, and 7.0 for removal to become pregnant; and .2, 1.2, and 1.4 for removal for personal reasons. The continuation rates were 95.1, 87.0, and 83.9 after 12, 24, and 36 months. There were 461, 373, and 149 insertions and 5755, 10,813, and 13,768 women-months of use in each of the 3 years. A multicenter study covering 925 insertions after 12 months showed 2 accidental pregnancies, 4 expulsions, 27 removals for pain and bleeding, 6 removals for infection, 10 removals for other medical reasons, and 16 removals to become pregnant. 89 patients were lost to follow-up. The continuation rate was 92, and the experience covered 9054 women-months of use. The patients were selected according to the usual criteria for IUD use. Most patients had at least 1 child and were at least 30 years old. The rates of expulsion and removal for pain and bleeding appear to be low, but a true comparative study has not been completed.

  15. Californium Recovery from Palladium Wire

    Energy Technology Data Exchange (ETDEWEB)

    Burns, Jon D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2014-08-01

    The recovery of 252Cf from palladium-252Cf cermet wires was investigated to determine the feasibility of implementing it into the cermet wire production operation at Oak Ridge National Laboratory’s Radiochemical Engineering Development Center. The dissolution of Pd wire in 8 M HNO3 and trace amounts of HCl was studied at both ambient and elevated temperatures. These studies showed that it took days to dissolve the wire at ambient temperature and only 2 hours at 60°C. Adjusting the ratio of the volume of solvent to the mass of the wire segment showed little change in the kinetics of dissolution, which ranged from 0.176 mL/mg down to 0.019 mL/mg. A successful chromatographic separation of 153Gd, a surrogate for 252Cf, from Pd was demonstrated using AG 50x8 cation exchange resin with a bed volume of 0.5 mL and an internal diameter of 0.8 cm.

  16. 42 CFR 403.250 - Loss ratio calculations: General provisions.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Loss ratio calculations: General provisions. 403.250 Section 403.250 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND... Certification Program: Loss Ratio Provisions § 403.250 Loss ratio calculations: General provisions. (a)...

  17. 7 CFR 58.250 - Dry whole milk.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Dry whole milk. 58.250 Section 58.250 Agriculture... Products Bearing Usda Official Identification § 58.250 Dry whole milk. Dry whole milk in commercial bulk... Grades of Dry Whole Milk. Quality requirements for dry whole milk in consumer packages shall be for...

  18. 30 CFR 250.302 - Definitions concerning air quality.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Definitions concerning air quality. 250.302... Definitions concerning air quality. For purposes of §§ 250.303 and 250.304 of this part: Air pollutant means..., pursuant to section 109 of the Clean Air Act, national primary or secondary ambient air quality...

  19. 46 CFR 28.250 - High water alarms.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false High water alarms. 28.250 Section 28.250 Shipping COAST... Individuals On Board, or for Fish Tender Vessels Engaged in the Aleutian Trade § 28.250 High water alarms. On... operating station to indicate high water level in each of the following normally unmanned spaces: (a)...

  20. 30 CFR 250.1606 - Control of wells.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Control of wells. 250.1606 Section 250.1606... OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1606 Control of wells. The lessee shall take necessary precautions to keep its wells under control at all times. Operations shall be...

  1. 41 CFR 60-250.22 - Direct threat defense.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Direct threat defense. 60-250.22 Section 60-250.22 Public Contracts and Property Management Other Provisions Relating to Public... VETERANS Discrimination Prohibited § 60-250.22 Direct threat defense. The contractor may use as...

  2. 41 CFR 60-250.24 - Drugs and alcohol.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Drugs and alcohol. 60-250... VETERANS Discrimination Prohibited § 60-250.24 Drugs and alcohol. (a) Specific activities permitted. The contractor: (1) May prohibit the illegal use of drugs and the use of alcohol at the workplace by...

  3. 30 CFR 250.1624 - Blowout prevention equipment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Blowout prevention equipment. 250.1624 Section 250.1624 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND... prevention equipment. (a) The BOP system and system components and related well-control equipment shall...

  4. 30 CFR 250.515 - Blowout prevention equipment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Blowout prevention equipment. 250.515 Section 250.515 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS... Blowout prevention equipment. (a) The BOP system and system components and related well-control...

  5. 30 CFR 250.1616 - Supervision, surveillance, and training.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Supervision, surveillance, and training. 250.1616 Section 250.1616 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... Supervision, surveillance, and training. (a) The lessee shall provide onsite supervision of...

  6. 42 CFR 84.250 - Vinyl chloride respirators; description.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Vinyl chloride respirators; description. 84.250... Respirators § 84.250 Vinyl chloride respirators; description. Vinyl chloride respirators, including all... escape from vinyl chloride atmospheres containing adequate oxygen to support life, are...

  7. 30 CFR 250.903 - What records must I keep?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What records must I keep? 250.903 Section 250.903 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND... the original material test results of all primary structural materials during all stages...

  8. 30 CFR 250.211 - What must the EP include?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must the EP include? 250.211 Section 250.211 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND... exploration drilling, well test flaring, installing a well protection structure, and temporary...

  9. 30 CFR 250.1609 - Pressure testing of casing.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Pressure testing of casing. 250.1609 Section 250.1609 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND.... (When oil or gas is not present in the cap rock, the production liner need not be cemented in...

  10. 50 CFR 600.250 - Council member training.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Council Membership § 600.250 Council... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Council member training. 600.250 Section... to matters before the Councils and shall make the training course available to all Council...

  11. 30 CFR 250.1202 - Liquid hydrocarbon measurement.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Liquid hydrocarbon measurement. 250.1202..., Surface Commingling, and Security § 250.1202 Liquid hydrocarbon measurement. (a) What are the requirements for measuring liquid hydrocarbons? You must: (1) Submit a written application to, and obtain...

  12. 41 CFR 60-250.43 - Affirmative action policy.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Affirmative action policy... OF LABOR 250-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS... PROTECTED VETERANS Affirmative Action Program § 60-250.43 Affirmative action policy. Under the...

  13. 7 CFR 250.30 - State processing of donated foods.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false State processing of donated foods. 250.30 Section 250.30 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION DONATION OF FOODS FOR USE IN...

  14. 17 CFR 250.3 - Exemption of certain banks.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exemption of certain banks... Exemptions § 250.3 Exemption of certain banks. (a) General exemption. Subject to the provisions of § 250.6 and to the requirements contained in paragraph (c) of this section, any bank shall be exempt from...

  15. 7 CFR 250.68 - Nutrition Services Incentive Program (NSIP).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Nutrition Services Incentive Program (NSIP). 250.68 Section 250.68 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION DONATION OF...

  16. Increased N250 amplitudes for other-race faces reflect more effortful processing at the individual level.

    Science.gov (United States)

    Herzmann, Grit

    2016-07-01

    The N250 and N250r (r for repetition, signaling a difference measure of priming) has been proposed to reflect the activation of perceptual memory representations for individual faces. Increased N250r and N250 amplitudes have been associated with higher levels of familiarity and expertise, respectively. In contrast to these observations, the N250 amplitude has been found to be larger for other-race than own-race faces in recognition memory tasks. This study investigated if these findings were due to increased identity-specific processing demands for other-race relative to own-race faces and whether or not similar results would be obtained for the N250 in a repetition priming paradigm. Only Caucasian participants were available for testing and completed two tasks with Caucasian, African-American, and Chinese faces. In a repetition priming task, participants decided whether or not sequentially presented faces were of the same identity (individuation task) or same race (categorization task). Increased N250 amplitudes were found for African-American and Chinese faces relative to Caucasian faces, replicating previous results in recognition memory tasks. Contrary to the expectation that increased N250 amplitudes for other-race face would be confined to the individuation task, both tasks showed similar results. This could be due to the fact that face identity information needed to be maintained across the sequential presentation of prime and target in both tasks. Increased N250 amplitudes for other-race faces are taken to represent increased neural demands on the identity-specific processing of other-race faces, which are typically processed less holistically and less on the level of the individual.

  17. Design of a homogeneous subcritical nuclear reactor based on thorium with a source of californium 252; Diseno de un reactor nuclear subcritico homogeneo a base de Torio con una fuente de Californio 252

    Energy Technology Data Exchange (ETDEWEB)

    Delgado H, C. E.; Vega C, H. R. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas, Zac. (Mexico); Sajo B, L., E-mail: ce_delgado89@hotmail.com [Universidad Simon Bolivar, Laboratorio de Fisica Nuclear, Apdo. 89000, 1080A Caracas (Venezuela, Bolivarian Republic of)

    2015-10-15

    Full text: One of the energy alternatives to fossil fuels which do not produce greenhouse gases is the nuclear energy. One of the drawbacks of this alternative is the generation of radioactive wastes of long half-life and its relation to the generation of nuclear materials to produce weapons of mass destruction. An option to these drawbacks of nuclear energy is to use Thorium as part of the nuclear fuel which it becomes in U{sup 233} when capturing neutrons, that is a fissile material. In this paper Monte Carlo methods were used to design a homogeneous subcritical reactor based on thorium. As neutron reflector graphite was used. The reactor core is homogeneous and is formed of 70% light water as moderator, 12% of enriched uranium UO{sub 2}(NO{sub 3}){sub 4} and 18% of thorium Th(NO{sub 3}){sub 4} as fuel. To start the nuclear fission chain reaction an isotopic source of californium 252 was used with an intensity of 4.6 x 10{sup 7} s{sup -1}. In the design the value of the effective multiplication factor, whose value turned out k{sub eff} <1 was calculated. Also, the neutron spectra at different distances from the source and the total fluence were calculated, as well as the values of the ambient dose equivalent in the periphery of the reactor. (Author)

  18. Manganese determination om minerals by activation analysis, using the californium-252 as a neutron source; Determinacao de manganes em minerios, por analise por ativacao, usando californio-252 como fonte de neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Cardoso, Antonio

    1976-07-01

    Neutron Activation Analysis, using a Californium-252 neutron source, has been applied for the determination of manganese in ores such as pyrolusite, rodonite (manganese silicate)' and blending used in dry-batteries The favorable nuclear properties of manganese, such as high thermal neutron cross-section for the reaction {sup 55}Mn (n.gamma){sup 56} Mn, high concentration of manganese in the matrix and short half - life of {sup 56}Mn, are an ideal combination for non-destructive analysis of manganese in ores. Samples and standards of manganese dioxide were irradiated for about 20 minutes, followed by a 4 to 15 minutes decay and counted in a single channel pulse-height discrimination using a NaI(Tl) scintillation detector. Counting time was equal to 10 minutes. The interference of nuclear reactions {sup 56}Fe(n,p){sup 56}Mn and {sup 59} Co (n, {alpha}){sup 56} were studied, as well as problems in connection with neutron shadowing during irradiation, gamma-rays attenuation during counting and influence of granulometry of samples. One sample,was also analysed by wet-chemical method (sodium bismuthate) in order to compare results. As a whole, i t was shown that the analytical method of neutron activation for manganese in ores and blending, is a method simple, rapid and with good precision and accuracy. (author)

  19. First demonstration of a vehicle mounted 250GHz real time passive imager

    Science.gov (United States)

    Mann, Chris

    2009-05-01

    This paper describes the design and performance of a ruggedized passive Terahertz imager, the frequency of operation is a 40GHz band centred around 250GHz. This system has been specifically targeted at vehicle mounted operation, outdoors in extreme environments. The unit incorporates temperature stabilization along with an anti-vibration chassis and is sealed to allow it to be used in a dusty environment. Within the system, a 250GHz heterodyne detector array is mated with optics and scanner to allow real time imaging out to 100 meters. First applications are envisaged to be stand-off, person borne IED detection to 30 meters but the unique properties in this frequency band present other potential uses such as seeing through smoke and fog. The possibility for use as a landing aid is discussed. A detailed description of the system design and video examples of typical imaging output will be presented.

  20. Superfund GIS - 1:250,000 Geology of Tennessee.

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set is a digital representation of the printed 1:250,000 geologic maps from the Tennessee Department of Environment and Conservation, Division of Geology....

  1. Alaska map quadrangles at 1:250,000 scale

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Outlines of 1:250,000 scale map quadrangles in Alaska for use as a geographic reference within Google Earth or other software capable of interpreting KML, with...

  2. Coomassie Brilliant Blue G-250 Dye: An Application for Forensic Fingerprint Analysis.

    Science.gov (United States)

    Brunelle, Erica; Le, Anh Minh; Huynh, Crystal; Wingfield, Kelly; Halámková, Lenka; Agudelo, Juliana; Halámek, Jan

    2017-04-04

    The Bradford reagent, comprised of the Coomassie Brilliant Blue G-250 dye, methanol, and phosphoric acid, has been traditionally used for quantifying proteins. Use of this reagent in the Bradford assay relies on the binding of the Coomassie Blue G-250 dye to proteins. However, the ability of the dye to react with a small group of amino acids (arginine, histidine, lysine, phenylalanine, tyrosine, and tryptophan) makes it a viable chemical assay for fingerprint analysis in order to identify the biological sex of the fingerprint originator. It is recognized that the identification of biological sex has been readily accomplished using two other methods; however, both of those systems are reliant upon a large group of amino acids, 23 to be precise. The Bradford assay, described here, was developed specifically to aid in the transition from targeting large groups of amino acids, as demonstrated in the previous studies, to targeting only a single amino acid without compromising the intensity of the response and/or the ability to differentiate between two attributes. In this work, we aim to differentiate between female fingerprints and male fingerprints.

  3. 30 CFR 250.803 - Additional production system requirements.

    Science.gov (United States)

    2010-07-01

    ... control shall be in effect for wells or fields having a history of sand production. The erosion-control... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Additional production system requirements. 250... OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Production...

  4. 5 CFR 250.202 - Office of Personnel Management responsibilities.

    Science.gov (United States)

    2010-01-01

    ... REGULATIONS PERSONNEL MANAGEMENT IN AGENCIES Strategic Human Capital Management § 250.202 Office of Personnel... Governmentwide leadership and direction in the strategic management of the Federal workforce. (b) To execute this... to which human capital management strategies are integrated into agency strategic plans...

  5. 5 CFR 250.201 - Coverage and purpose.

    Science.gov (United States)

    2010-01-01

    ....201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT IN AGENCIES Strategic Human Capital Management § 250.201 Coverage and purpose. The Chief Human... the strategic management of the Federal civil service, and pursuant to 5 U.S.C. 1103, OPM...

  6. 7 CFR 250.50 - Contract requirements and procurement.

    Science.gov (United States)

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION DONATION OF FOODS FOR USE IN THE... Contracts With Food Service Management Companies § 250.50 Contract requirements and procurement. (a) Contract requirements. Prior to donated foods being made available to a food service management...

  7. 7 CFR 250.54 - Recordkeeping and reviews.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION DONATION OF FOODS FOR USE IN THE UNITED STATES... Service Management Companies § 250.54 Recordkeeping and reviews. (a) Recordkeeping requirements for the... foods in its contract with the food service management company: (1) The donated foods and processed...

  8. 40 CFR 61.250 - Designation of facilities.

    Science.gov (United States)

    2010-07-01

    ... Emissions From Operating Mill Tailings § 61.250 Designation of facilities. The provisions of this subpart apply to owners or operators of facilities licensed to manage uranium byproduct materials during and following the processing of uranium ores, commonly referred to as uranium mills and their...

  9. 38 CFR 21.250 - Overview of employment services.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Vocational Rehabilitation and Employment Under 38 U.S.C. Chapter 31 Employment Services § 21.250 Overview of employment services. (a) General. Employment services... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Overview of...

  10. 41 CFR 60-250.64 - Show cause notices.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Show cause notices. 60... VETERANS General Enforcement and Complaint Procedures § 60-250.64 Show cause notices. When the Deputy Assistant Secretary has reasonable cause to believe that the contractor has violated the Act or this...

  11. 7 CFR 250.16 - Maintenance of records.

    Science.gov (United States)

    2010-01-01

    ... processor, food service management company, warehouse, or other entity which contracts with a distributing... management company, warehouse or other entity to maintain records required by this Section shall be... offer-and-acceptance system in accordance with § 250.48(e), the distributing agency shall...

  12. 38 CFR 3.250 - Dependency of parents; compensation.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Dependency of parents....250 Dependency of parents; compensation. (a) Income—(1) Conclusive dependency. Dependency of a parent... not exceed: (i) $400 for a mother or father not living together; (ii) $660 for a mother and father,...

  13. 30 CFR 250.511 - Traveling-block safety device.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Traveling-block safety device. 250.511 Section... Traveling-block safety device. All units being used for well-completion operations that have both a traveling block and a crown block must be equipped with a safety device that is designed to prevent...

  14. 30 CFR 250.611 - Traveling-block safety device.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Traveling-block safety device. 250.611 Section... Traveling-block safety device. After May 31, 1989, all units being used for well-workover operations which have both a traveling block and a crown block shall be equipped with a safety device which is...

  15. 40 CFR 725.250 - Procedural requirements for the TERA.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Procedural requirements for the TERA... and Development Activities § 725.250 Procedural requirements for the TERA. General requirements for... following requirements apply to TERAs submitted under this subpart: (a) When to submit the TERA. Each...

  16. 7 CFR 250.62 - Summer Food Service Program (SFSP).

    Science.gov (United States)

    2010-01-01

    ....62 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION DONATION OF FOODS FOR USE IN THE... Program (NSLP) and Other Child Nutrition Programs § 250.62 Summer Food Service Program (SFSP)....

  17. The Varian MAT-250 mass spectrometer. Steady isotopes laboratory; Espectrometro de masas Varian MAT-250. Laboratorio de isotopos estables

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez M, V.; Tavera D, M.L. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1997-07-01

    This work treats over the performance and applications of the Varian Mat-250 mass spectrometer which is in the environmental isotope laboratory. It can be applied over topics such as: ions formation, acceleration and collimation, ions separation, ions detection, data transformation, sampling, {delta} notation. (Author)

  18. Target Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — [Part of the ATLAS user facility.] The Physics Division operates a target development laboratory that produces targets and foils of various thickness and substrates,...

  19. 41 CFR 60-250.41 - Availability of affirmative action program.

    Science.gov (United States)

    2010-07-01

    ... affirmative action program. 60-250.41 Section 60-250.41 Public Contracts and Property Management Other... OPPORTUNITY, DEPARTMENT OF LABOR 250-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND... OTHER PROTECTED VETERANS Affirmative Action Program § 60-250.41 Availability of affirmative...

  20. 41 CFR 60-250.40 - Applicability of the affirmative action program requirement.

    Science.gov (United States)

    2010-07-01

    ... affirmative action program requirement. 60-250.40 Section 60-250.40 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 250-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF... SEPARATED VETERANS, AND OTHER PROTECTED VETERANS Affirmative Action Program § 60-250.40 Applicability of...

  1. A phase II trial of chimeric monoclonal antibody G250 for advanced renal cell carcinoma patients.

    NARCIS (Netherlands)

    Bleumer, I.; Knuth, A.; Oosterwijk, E.; Hofmann, R.; Varga, Z.; Lamers, C.B.H.W.; Kruit, W.; Melchior, S.; Mala, C.; Ullrich, S.; Mulder, P.; Mulders, P.F.A.; Beck, J.L.M.

    2004-01-01

    Chimeric monoclonal antibody G250 (WX-G250) binds to a cell surface antigen found on >90% of renal cell carcinoma (RCC). A multicentre phase II study was performed to evaluate the safety and efficacy of WX-G250 in metastatic RCC (mRCC) patients. In all, 36 patients with mRCC were included. WX-G250 w

  2. Navy Advertising: Targeting Generation Z

    Science.gov (United States)

    2015-12-01

    influence the navy recruiting and advertising goals. Results from our study can influence advertisement targeting goals and also better aid in the...250 advertising studies to deduce a formula on how advertising works . They developed a framework, seen in Figure 2, to help classify the advertising...advertising works : What do we really know? Journal of Marketing, 63(1), 26-43. By using the framework and classifying studies into different models

  3. Development Status of Power Processing Unit for 250mN-Class Hall Thruster

    Science.gov (United States)

    Osuga, H.; Suzuki, K.; Ozaki, T.; Nakagawa, T.; Suga, I.; Tamida, T.; Akuzawa, Y.; Suzuki, H.; Soga, Y.; Furuichi, T.; Maki, S.; Matui, K.

    2008-09-01

    Institute for Unmanned Space Experiment Free Flyer (USEF) and Mitsubishi Electric Corporation (MELCO) are developing the next generation ion engine system under the sponsorship of Ministry of Economy, Trade and Industry (METI) within six years. The system requirement specifications are a thrust level of over 250mN and specific impulse of over 1500 sec with a less than 5kW electric power supply, and a lifetime of over 3,000 hours. These target specifications required the development of both a Hall Thruster and a Power Processing Unit (PPU). In the 2007 fiscal year, the PPU called Second Engineering Model (EM2) consist of all power supplies was a model for the Hall Thruster system. The EM2 PPU showed the discharge efficiency was over 96.2% for 250V and 350V at output power between 1.8kW to 4.5kW. And also the Hall Thruster could start up quickly and smoothly to control the discharge voltage, the inner magnet current, the outer magnet current and the xenon flow rate. This paper reports on the design and test results of the EM2 PPU.

  4. 小猪和小虎——SUZUKI TU250 Volty VS Kawasaki Estrella

    Institute of Scientific and Technical Information of China (English)

    杜启弘; 徐天翔

    2005-01-01

    在日本250毫升复古车中.四大厂家各自推出了自己的代表车型。雅马哈的SRV250.本田的GB250.铃木TU250 Volty、川崎Estrella。其中,GB250大获成功,SRV250则表现平平,TU250 Volty和Estrella则紧紧咬住GB250.在日本国内和国外市场上均取得不错的销量。本期试车我们就将对铃木TU250和川崎的Estrella进行对比测试。

  5. Towards 250 m mapping of terrestrial primary productivity over Canada

    Science.gov (United States)

    Gonsamo, A.; Chen, J. M.

    2011-12-01

    Terrestrial ecosystems are an important part of the climate and global change systems. Their role in climate change and in the global carbon cycle is yet to be well understood. Dataset from satellite earth observation, coupled with numerical models provide the unique tools for monitoring the spatial and temporal dynamics of territorial carbon cycle. The Boreal Ecosystems Productivity Simulator (BEPS) is a remote sensing based approach to quantifying the terrestrial carbon cycle by that gross and net primary productivity (GPP and NPP) and terrestrial carbon sinks and sources expressed as net ecosystem productivity (NEP). We have currently implemented a scheme to map the GPP, NPP and NEP at 250 m for first time over Canada using BEPS model. This is supplemented by improved mapping of land cover and leaf area index (LAI) at 250 m over Canada from MODIS satellite dataset. The results from BEPS are compared with MODIS GPP product and further evaluated with estimated LAI from various sources to evaluate if the results capture the trend in amount of photosynthetic biomass distributions. Final evaluation will be to validate both BEPS and MODIS primary productivity estimates over the Fluxnet sites over Canada. The primary evaluation indicate that BEPS GPP estimates capture the over storey LAI variations over Canada very well compared to MODIS GPP estimates. There is a large offset of MODIS GPP, over-estimating the lower GPP value compared to BEPS GPP estimates. These variations will further be validated based on the measured values from the Fluxnet tower measurements over Canadian. The high resolution GPP (NPP) products at 250 m will further be used to scale the outputs between different ecosystem productivity models, in our case the Canadian carbon budget model of Canadian forest sector CBM-CFS) and the Integrated Terrestrial Ecosystem Carbon model (InTEC).

  6. Acquisition of a 250-word vocabulary through a tactile vocoder.

    Science.gov (United States)

    Brooks, P L; Frost, B J; Mason, J L; Chung, K

    1985-04-01

    In a previous experiment [P. L. Scilley, "Evaluation of a vibrotactile auditory prosthetic device for the profoundly deaf," unpublished Masters thesis, Queen's University, Kingston, Canada (1980)] two normal subjects learned to identify 70 and 150 words, respectively, using the Queen's Tactile Vocoder. In the present experiment, the most advanced subject continued word learning until a tactile vocabulary of 250 words was acquired. At this point randomized tests were given to obtain an indication of final performance level. From these data conditional probabilities of correct response for each stimulus word and significant confusions were obtained, which provides insight into the advantages and present limitations of the tactile vocoder.

  7. A Supercritical 250 kW Industrial Air Compressor Prototype

    Science.gov (United States)

    Lantto, Erkki; Tommila, Ville

    This paper presents the active magnetic bearing control system synthesis and practical rotor dynamic experiences with a supercritical 250 kW turbo compressor. First, the physical boundary conditions of passing the first bending critical speed and feasible bearing characteristics near the critical speed are considered. Then, the control system is synthesized and analyzed using complex formulation. A synchronous response controller is added in parallel with the position controller in order to achieve the preferred bearing characteristics. Finally, measured performance of the control system when passing the critical speed with a real life compressor is presented.

  8. SWI/SNF Protein Component BAF250a Regulates Cardiac Progenitor Cell Differentiation by Modulating Chromatin Accessibility during Second Heart Field Development*

    Science.gov (United States)

    Lei, Ienglam; Gao, Xiaolin; Sham, Mai Har; Wang, Zhong

    2012-01-01

    ATP-dependent SWI/SNF chromatin remodeling complexes alter the structure of chromatin at specific loci and facilitate tissue-specific gene regulation during development. Several SWI/SNF subunits are required for cardiogenesis. However, the function and mechanisms of SWI/SNF in mediating cardiac progenitor cell (CPC) differentiation during cardiogenesis are not well understood. Our studies of the SWI/SNF chromatin remodeling complex identified that BAF250a, a regulatory subunit of the SWI/SNF, plays a key role in CPC differentiation. BAF250a ablation in mouse second heart field (SHF) led to trabeculation defects in the right ventricle, ventricular septal defect, persistent truncus arteriosus, reduced myocardial proliferation, and embryonic lethality around E13. Using an embryonic stem cell culture system that models the formation and differentiation of SHF CPCs in vivo, we have shown that BAF250a ablation in CPCs specifically inhibits cardiomyocyte formation. Moreover, BAF250a selectively regulates the expression of key cardiac factors Mef2c, Nkx2.5, and Bmp10 in SHF CPCs. Chromatin immunoprecipitation and DNase I digestion assays indicate that BAF250a regulates gene expression by binding selectively to its target gene promoters and recruiting Brg1, the catalytic subunit of SWI/SNF, to modulate chromatin accessibility. Our results thus identify BAF250a-mediated chromatin remodeling as an essential epigenetic mechanism mediating CPC differentiation. PMID:22621927

  9. SWI/SNF protein component BAF250a regulates cardiac progenitor cell differentiation by modulating chromatin accessibility during second heart field development.

    Science.gov (United States)

    Lei, Ienglam; Gao, Xiaolin; Sham, Mai Har; Wang, Zhong

    2012-07-13

    ATP-dependent SWI/SNF chromatin remodeling complexes alter the structure of chromatin at specific loci and facilitate tissue-specific gene regulation during development. Several SWI/SNF subunits are required for cardiogenesis. However, the function and mechanisms of SWI/SNF in mediating cardiac progenitor cell (CPC) differentiation during cardiogenesis are not well understood. Our studies of the SWI/SNF chromatin remodeling complex identified that BAF250a, a regulatory subunit of the SWI/SNF, plays a key role in CPC differentiation. BAF250a ablation in mouse second heart field (SHF) led to trabeculation defects in the right ventricle, ventricular septal defect, persistent truncus arteriosus, reduced myocardial proliferation, and embryonic lethality around E13. Using an embryonic stem cell culture system that models the formation and differentiation of SHF CPCs in vivo, we have shown that BAF250a ablation in CPCs specifically inhibits cardiomyocyte formation. Moreover, BAF250a selectively regulates the expression of key cardiac factors Mef2c, Nkx2.5, and Bmp10 in SHF CPCs. Chromatin immunoprecipitation and DNase I digestion assays indicate that BAF250a regulates gene expression by binding selectively to its target gene promoters and recruiting Brg1, the catalytic subunit of SWI/SNF, to modulate chromatin accessibility. Our results thus identify BAF250a-mediated chromatin remodeling as an essential epigenetic mechanism mediating CPC differentiation.

  10. Transcript analysis of 250 novel yeast genes from chromosome XIV.

    Science.gov (United States)

    Planta, R J; Brown, A J; Cadahia, J L; Cerdan, M E; de Jonge, M; Gent, M E; Hayes, A; Kolen, C P; Lombardia, L J; Sefton, M; Oliver, S G; Thevelein, J; Tournu, H; van Delft, Y J; Verbart, D J; Winderickx, J

    1999-03-15

    The European Functional Analysis Network (EUROFAN) is systematically analysing the function of novel Saccharomyces cerevisiae genes revealed by genome sequencing. As part of this effort our consortium has performed a detailed transcript analysis for 250 novel ORFs on chromosome XIV. All transcripts were quantified by Northern analysis under three quasi-steady-state conditions (exponential growth on rich fermentative, rich non-fermentative, and minimal fermentative media) and eight transient conditions (glucose derepression, glucose upshift, stationary phase, nitrogen starvation, osmo-stress, heat-shock, and two control conditions). Transcripts were detected for 82% of the 250 ORFs, and only one ORF did not yield a transcript of the expected length (YNL285w). Transcripts ranged from low (62%), moderate (16%) to high abundance (2%) relative to the ACT1 mRNA. The levels of 73% of the 206 chromosome XIV transcripts detected fluctuated in response to the transient states tested. However, only a small number responded strongly to the transients: eight ORFs were induced upon glucose upshift; five were repressed by glucose; six were induced in response to nitrogen starvation; three were induced in stationary phase; five were induced by osmo-stress; four were induced by heat-shock. These data provide useful clues about the general function of these ORFs and add to our understanding of gene regulation on a genome-wide basis.

  11. 30 CFR 250.1159 - May the Regional Supervisor limit my well or reservoir production rates?

    Science.gov (United States)

    2010-07-01

    ... based on well tests and any limitations imposed by well and surface equipment, sand production... reservoir production rates? 250.1159 Section 250.1159 Mineral Resources MINERALS MANAGEMENT SERVICE... Gas Production Requirements Production Rates § 250.1159 May the Regional Supervisor limit my well...

  12. 20 CFR 404.250 - Special computation rules for people who had a period of disability.

    Science.gov (United States)

    2010-04-01

    ... Computation Rules for People Who Had A Period of Disability § 404.250 Special computation rules for people who... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Special computation rules for people who had a period of disability. 404.250 Section 404.250 Employees' Benefits SOCIAL SECURITY...

  13. 30 CFR 250.174 - When may the Regional Supervisor grant or direct an SOP?

    Science.gov (United States)

    2010-07-01

    ... direct an SOP? 250.174 Section 250.174 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... § 250.174 When may the Regional Supervisor grant or direct an SOP? The Regional Supervisor may grant or direct an SOP when the suspension is in the national interest, and it is necessary because the...

  14. 30 CFR 250.173 - When may the Regional Supervisor direct an SOO or SOP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When may the Regional Supervisor direct an SOO or SOP? 250.173 Section 250.173 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... § 250.173 When may the Regional Supervisor direct an SOO or SOP? The Regional Supervisor may direct...

  15. 30 CFR 250.444 - What are the choke manifold requirements?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the choke manifold requirements? 250.444 Section 250.444 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE... Blowout Preventer (bop) System Requirements § 250.444 What are the choke manifold requirements? (a)...

  16. 21 CFR 250.201 - Preparations for the treatment of pernicious anemia.

    Science.gov (United States)

    2010-04-01

    ... anemia. 250.201 Section 250.201 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... Drugs and Foods § 250.201 Preparations for the treatment of pernicious anemia. (a) The ninth announcement of the Anti-anemia Preparations Advisory Board of the United States Pharmacopeia is concerned...

  17. 17 CFR 250.27 - Classification of accounts prescribed for utility companies not already subject thereto.

    Science.gov (United States)

    2010-04-01

    ... HOLDING COMPANY ACT OF 1935 Forms, Procedure and Accounts § 250.27 Classification of accounts prescribed... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Classification of accounts prescribed for utility companies not already subject thereto. 250.27 Section 250.27 Commodity and...

  18. 13 CFR 107.250 - Exclusion of stock options issued by Licensee from Management Expenses.

    Science.gov (United States)

    2010-01-01

    ... Sbic § 107.250 Exclusion of stock options issued by Licensee from Management Expenses. Stock options... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Exclusion of stock options issued by Licensee from Management Expenses. 107.250 Section 107.250 Business Credit and Assistance...

  19. 30 CFR 772.11 - Notice requirements for exploration removing 250 tons of coal or less.

    Science.gov (United States)

    2010-07-01

    ... 250 tons of coal or less. 772.11 Section 772.11 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION... requirements for exploration removing 250 tons of coal or less. (a) Any person who intends to conduct coal exploration operations outside a permit area during which 250 tons or less of coal will be removed,...

  20. 30 CFR 250.215 - What hydrogen sulfide (H2S) information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What hydrogen sulfide (H2S) information must accompany the EP? 250.215 Section 250.215 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Contents of Exploration Plans (ep) § 250.215 What hydrogen sulfide (H2S) information must accompany the...

  1. 48 CFR 52.250-1 - Indemnification Under Public Law 85-804.

    Science.gov (United States)

    2010-10-01

    ... Public Law 85-804. 52.250-1 Section 52.250-1 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.250-1 Indemnification Under Public Law 85-804. As prescribed in 50.104-4, insert the following clause: Indemnification Under Public Law 85-804 (APR 1984) (a) Contractor's principal officials, as...

  2. 20 CFR 1010.250 - Can priority of service be waived?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Can priority of service be waived? 1010.250 Section 1010.250 Employees' Benefits OFFICE OF THE ASSISTANT SECRETARY FOR VETERANS' EMPLOYMENT AND... Priority of Service § 1010.250 Can priority of service be waived? No, priority of service cannot be waived....

  3. 30 CFR 250.1010 - General requirements for pipeline right-of-way holders.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false General requirements for pipeline right-of-way holders. 250.1010 Section 250.1010 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Rights-of-Way § 250.1010 General requirements for pipeline right-of-way holders. An applicant,...

  4. 30 CFR 250.226 - What Coastal Zone Management Act (CZMA) information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What Coastal Zone Management Act (CZMA) information must accompany the EP? 250.226 Section 250.226 Mineral Resources MINERALS MANAGEMENT SERVICE... and Information Contents of Exploration Plans (ep) § 250.226 What Coastal Zone Management Act...

  5. 30 CFR 250.109 - What documents must I prepare and maintain related to welding?

    Science.gov (United States)

    2010-07-01

    ... related to welding? 250.109 Section 250.109 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF... Performance Standards § 250.109 What documents must I prepare and maintain related to welding? (a) You must submit a Welding Plan to the District Manager before you begin drilling or production activities on...

  6. 32 CFR 250.7 - Pertinent portions of Export Administration Regulations (EAR).

    Science.gov (United States)

    2010-07-01

    ... Regulations (EAR). 250.7 Section 250.7 National Defense Department of Defense (Continued) OFFICE OF THE... DISCLOSURE § 250.7 Pertinent portions of Export Administration Regulations (EAR). The following pertinent section of the EAR is provided for the guidance of DoD personnel in determining the...

  7. 30 CFR 250.1012 - Required payments for pipeline right-of-way holders.

    Science.gov (United States)

    2010-07-01

    ... in 30 CFR 218.54. If you fail to make a payment that is late after written notice from MMS, MMS may initiate cancellation of the right-of-use grant and easement under 30 CFR 250.1013. ... holders. 250.1012 Section 250.1012 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF...

  8. 30 CFR 250.1011 - Bond requirements for pipeline right-of-way holders.

    Science.gov (United States)

    2010-07-01

    ... holders. 250.1011 Section 250.1011 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Rights-of-Way § 250.1011 Bond requirements for pipeline right-of-way holders. (a) When you apply for, or are the holder of, a right-of-way, you must: (1) Provide and maintain a $300,000 bond (in addition...

  9. 30 CFR 250.411 - What information must I submit with my application?

    Science.gov (United States)

    2010-07-01

    ... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.411 What information must I submit with my application? In addition to... proposed well § 250.412 (b) Design criteria used for the proposed well § 250.413 (c) Drilling...

  10. Bayesian demography 250 years after Bayes.

    Science.gov (United States)

    Bijak, Jakub; Bryant, John

    2016-01-01

    Bayesian statistics offers an alternative to classical (frequentist) statistics. It is distinguished by its use of probability distributions to describe uncertain quantities, which leads to elegant solutions to many difficult statistical problems. Although Bayesian demography, like Bayesian statistics more generally, is around 250 years old, only recently has it begun to flourish. The aim of this paper is to review the achievements of Bayesian demography, address some misconceptions, and make the case for wider use of Bayesian methods in population studies. We focus on three applications: demographic forecasts, limited data, and highly structured or complex models. The key advantages of Bayesian methods are the ability to integrate information from multiple sources and to describe uncertainty coherently. Bayesian methods also allow for including additional (prior) information next to the data sample. As such, Bayesian approaches are complementary to many traditional methods, which can be productively re-expressed in Bayesian terms.

  11. Remote (250 km Fiber Bragg Grating Multiplexing System

    Directory of Open Access Journals (Sweden)

    Manuel Lopez-Amo

    2011-09-01

    Full Text Available We propose and demonstrate two ultra-long range fiber Bragg grating (FBG sensor interrogation systems. In the first approach four FBGs are located 200 km from the monitoring station and a signal to noise ratio of 20 dB is obtained. The second improved version is able to detect the four multiplexed FBGs placed 250 km away, offering a signal to noise ratio of 6–8 dB. Consequently, this last system represents the longest range FBG sensor system reported so far that includes fiber sensor multiplexing capability. Both simple systems are based on a wavelength swept laser to scan the reflection spectra of the FBGs, and they are composed by two identical-lengths optical paths: the first one intended to launch the amplified laser signal by means of Raman amplification and the other one is employed to guide the reflection signal to the reception system.

  12. Corrosion of titanium in phosphoric acid at 250

    Institute of Scientific and Technical Information of China (English)

    LU Jian-shu

    2009-01-01

    Corrosion studies of a commercially pure titanium in phosphoric acid solutions at 250 ℃ were carried out by immersion test in an autoclave. At lower phosphoric acid concentration (0.1 mol/L), the corrosion was mild. At higher phosphoric concentration (1.0 mol/L) corrosion, a 25 μm-thick white corrosion products layer was formed on the samples after 24 h immersion. XRD analysis shows that the white layer consists mainly of titanium oxide phosphate hydrate (π-Ti2O(PO4)2·2H2O). The corrosion product shows the morphology of fiber bundles. A thermodynamic analysis of the formation of the corrosion product is presented.

  13. 40 CFR 1065.250 - Nondispersive infra-red analyzer.

    Science.gov (United States)

    2010-07-01

    ... analyzer that has compensation algorithms that are functions of other gaseous measurements and the engine's known or assumed fuel properties. The target value for any compensation algorithm is 0.0% (that is,...

  14. Antiproton Target

    CERN Multimedia

    1980-01-01

    Antiproton target used for the AA (antiproton accumulator). The first type of antiproton production target used from 1980 to 1982 comprised a rod of copper 3mm diameter and 120mm long embedded in a graphite cylinder that was itself pressed into a finned aluminium container. This assembly was air-cooled and it was used in conjunction with the Van der Meer magnetic horn. In 1983 Fermilab provided us with lithium lenses to replace the horn with a view to increasing the antiproton yield by about 30%. These lenses needed a much shorter target made of heavy metal - iridium was chosen for this purpose. The 50 mm iridium rod was housed in an extension to the original finned target container so that it could be brought very close to the entrance to the lithium lens. Picture 1 shows this target assembly and Picture 2 shows it mounted together with the lithium lens. These target containers had a short lifetime due to a combination of beam heating and radiation damage. This led to the design of the water-cooled target in...

  15. The Undergraduate ALFALFA Team: Outcomes for Over 250 Undergraduate Participants

    Science.gov (United States)

    Troischt, Parker; Koopmann, Rebecca A.; Haynes, Martha P.; ALFALFA Team

    2016-01-01

    The NSF-sponsored Undergraduate ALFALFA (Arecibo Legacy Fast ALFA) Team (UAT) is a consortium of 19 institutions founded to promote undergraduate research and faculty development within the extragalactic ALFALFA HI blind survey project and follow-up programs. In this talk we present outcomes for the more than 250 undergraduate students who have who have participated in the program during the 8 years of funding. 40% of these students have been women and members of underrepresented groups. To date 148 undergraduate students have attended annual workshops at Arecibo Observatory, interacting with faculty, graduate students, their peers, and Arecibo staff in lectures, group activities, tours, and observing runs. Team faculty have supervised 159 summer research projects and 120 academic year (e.g., senior thesis) projects. 68 students have traveled to Arecibo Observatory for observing runs and 55 have presented their results at national meetings such as the AAS. Through participation in the UAT, students are made aware of career paths they may not have previously considered. More than 90% of alumni are attending graduate school and/or pursuing a career in STEM. 42% of those pursuing graduate degrees in Physics or Astronomy are women. This work has been supported by NSF grants AST-0724918/0902211, AST-075267/0903394, AST-0725380, and AST-1211005

  16. Grammaire pour adolescents 250 exercices : niveau débutant

    CERN Document Server

    Bié, Nathalie

    2005-01-01

    Ce nouveau livre d'exercices de grammaire, de la collection Le Nouvel Entraînez-vous, s'adresse à un public d'adolescents débutants et faux débutants en français langue étrangère. L'ouvrage propose 250 exercices de compréhension et de mémorisation à travers des activités de déduction et de réemploi des notions grammaticales étudiées. Le contenu des exercices est organisé autour de contextes langagiers proches de la réalité des adolescents afin de placer la communication au cœur de l'apprentissage. L'introduction des contenus grammaticaux suit la même progression que les méthodes usuelles. Chaque chapitre débute par une séquence Rappel permettant à l'apprenant de revoir rapidement les règles grammaticales développées dans les exercices. Chaque exercice est introduit par une consigne brève et concise accompagnée d'un exemple. L'ouvrage a été conçu en tenant compte des centres d'intérêts des adolescents et propose de nombreuses illustrations intégrées aux exercices. A la fin d...

  17. Adjustable Shock Test Sled for Haversine Pulses at 250 fps

    Energy Technology Data Exchange (ETDEWEB)

    Hartwig, Troy [Honeywell Federal Manufacturing and Technologies, Kansas City, MO (United States); Hower, Brent [Honeywell Federal Manufacturing and Technologies, Kansas City, MO (United States); Seaholm, Aaron [Honeywell Federal Manufacturing and Technologies, Kansas City, MO (United States)

    2007-11-08

    New test requirements were developed by Sandia National Laboratory to simulate a regime of shock testing not previously performed at the Kansas City Plant operated by Honeywell Federal Manufacturing & Technologies. These environments were unique in that they involved amplitude of shock >1000g with relatively long pulse durations (greater 5 ms but less than 10 ms) and involved velocity changes up to 235 ft/sec. Ten months were available to develop, design, manufacture and prove-in this new capability. We designed a new shock sled to deliver this new family of shock environments in a laboratory test. The performance range of the new sled includes five specific shocks (1000 g – 8 ms, 1300 - 6 ms, 1500 g – 5.4 ms, 1950 g – 6 ms, 2250 g – 5.4 ms; all haversine shaped), and it also incorporates adjustability to accommodate new shocks within this range. These shock environments result in velocity changes ranging from 160 fps to 250 fps. The test sled accommodates test articles weighing up to 20 lbs and measuring up to 10” along any axis.

  18. Bionics by examples 250 scenarios from classical to modern times

    CERN Document Server

    Nachtigall, Werner

    2015-01-01

    Bionics means learning from the nature for the development of technology. The science of "bionics" itself is classified into several sections, from materials and structures over procedures and processes until evolution and optimization. Not all these areas, or only a few, are really known in the public and also in scientific literature. This includes the Lotus-effect, converted to the contamination-reduction of fassades and the shark-shed-effect, converted to the  resistance-reduction of airplanes. However, there are hundreds of highly interesting examples that contain the transformation of principles of the nature into technology. From the large number of these examples, 250 were selected for the present book according to "prehistory", "early-history", "classic" and "modern time". Most examples are new. Every example includes a printed page in a homogeneous arrangement. The examples from the field "modern time" are joint in blocks corresponding to the sub-disciplines of bionics.

  19. Evaluation of some aspects of the VITROS 250 Bio-Chemistry analyzer%VITROS 250全自动干化学分析仪的评价

    Institute of Scientific and Technical Information of China (English)

    林有东; 蔡鹏威

    2006-01-01

    目的 评价美国强生VITROS 250全自动干化学分析仪器.方法 运用相关统计学方法对VITROS 250全自动干化学分析仪的精密度、相关性、抗胆红素干扰方面进行分析.结果 VITROS 250全自动干化学分析仪精密度高,回收率高,相关性好,抗干扰能力强.结论 VITROS 250全自动干化学分析仪适用于临床实验诊断中心(检验科)急诊化验室生化项目的检测.

  20. Targeted Learning

    CERN Document Server

    van der Laan, Mark J

    2011-01-01

    The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the targe

  1. Investigation of Ka-Band CW 250 W TWT%Ka波段250W连续波行波管的研制

    Institute of Scientific and Technical Information of China (English)

    冯晨; 杨明华; 黄拓朴

    2011-01-01

    本文介绍了一种Ka波段连续波250 W螺旋线行波管研制的主要技术方案.介绍了这种行波管的研究现状和研制成果.%This paper presents the main technology scheme of a CW 250 W Ka-band helix TWT. The current situation of this TWT and the research achievements are introduced.

  2. Study of solar features causing GMSs with 250 < < 400

    Indian Academy of Sciences (India)

    Santosh Kumar; Mahendra Pratap Yadav

    2003-07-01

    The effect of solar features on geospheric conditions leading to geomagnetic storms (GMSs) with planetary index, p ≥ 20 and the range of horizontal component of the Earth’s magnetic field such that 250 < < 400 has been investigated using interplanetary magnetic field (IMF), solar wind plasma (SWP) and solar geophysical data (SGD) during the period 1978–99. Statistically, it is observed that maximum number of GMSs have occurred during the maximum solar activity years of 21st and 22nd solar cycles. A peculiar result has been observed during the years 1982, 1994 when sunspot numbers (SSNs) decrease very rapidly while numbers of GMSs increase. No distinct association between yearly occurrence of disturbed days and SSNs is observed. Maximum number of disturbed days have occurred during spring and rainy seasons showing a seasonal variation of disturbed days. No significant correlation between magnitude (intensity) of GMSs and importance of , X-ray solar flares has been observed. Maximum number of GMSs is associated with solar flares of lower importance, i.e., SF during the period 1978–93. , X-ray solar flares occurred within lower helio-latitudes, i.e., (0–30)°N to (0–30)°S are associated with GMSs. No , X-ray solar flares have occurred beyond 40°N or 40°S in association with GMSs. In helio-latitude range (10–40)°N to (10–40)°S, the 89.5% concentration of active prominences and disappearing filaments (APDFs) are associated with GMSs. Maximum number of GMSs are associated with solar flares. Coronal mass ejections (CMEs) are related with eruptive prominences, solar flares, type IV radio burst and they occur at low helio-latitude. It is observed that CMEs related GMS events are not always associated with high speed solar wind streams (HSSWSs). In many individual events, the travel time between the explosion on the Sun and maximum activity lies between 58 and 118 h causing GMSs at the Earth.

  3. 250 labels used to stigmatise people with mental illness

    Directory of Open Access Journals (Sweden)

    Pinfold Vanessa

    2007-06-01

    Full Text Available Abstract Background The stigma against people with mental illness is a major barrier to help-seeking in young people for mental health problems. The objective of this study was to investigate the extent of stigma in relation to treatment avoidance in 14 year-old school students in England in relation to how they refer to people with mental illness. Methods This is a qualitative, cross-sectional study. The data were gathered as part of the baseline assessment for an intervention study intended to reduce stigma among 14 year old school students. The participating schools were two grammar (selective schools and three comprehensive (non-selective schools. At the start of the lesson, the students were asked 'What sorts of words or phrases might you use to describe someone who experiences mental health problems?' Words and terms used to refer to mental illness were enumerated. Using the grounded theory approach, words and terms were grouped in terms of their denotative and connotative meanings. Labels were then derived to capture the key themes attached by the students to the concepts of mental illness. The frequencies of occurrence for each word were also tabulated. Results 400 of the 472 participating students (85% provided 250 words and terms to describe a person with mental illness. Five themes were identified from the data. The first theme called 'popular derogatory terms' (116 items accounted for nearly half of the words examined. The second theme occurred less often and was described as 'negative emotional state' (61 items. The third theme demonstrated the confusion of young people between physical disabilities, learning difficulties and mental health problems (38 items. The use of psychiatric diagnoses (15 items and terms related to violence (9 items were unexpectedly uncommon. Conclusion Our findings suggest the hypothesis that help-seeking by mentally ill young people may be improved by interventions that address both their lack of factual

  4. Hydrological variability in northern Levant over the past 250 ka

    Directory of Open Access Journals (Sweden)

    F. Gasse

    2011-05-01

    Full Text Available The Levant features sharp climatic gradients from North to South and from West to East resulting in a large environmental diversity. The lack of long-term record from the northern Levant limits our understanding of the regional response to glacial-interglacial boundary conditions in this key area. The 250 ka paleoenvironmental reconstruction presented here is a first step to fill this geographical gap.

    The record comes from a 36 m lacustrine-palustrine sequence cored in the small intra-mountainous karstic basin of Yammoûneh (northern Lebanon. The paper combines times series of sediment properties, paleovegetation, and carbonate oxygen isotopes, to yield a comprehensive view of paleohydrologic-paleoclimatic fluctuations in the basin over the two last glacial-interglacial cycles. Efficient moisture was higher than today during interglacial peaks around 240, 215–220, ~130–120 ka and 11–9 ka (although under different Precipitation minus Evaporation balance. Moderate wetting events took place around 170, 150, 105–100, 85–75, 60–55 and 35 ka. The penultimate glacial period was generally wetter than the last glacial stage. Local aridity culminated from the LGM to 15 ka, possibly linked to water storage as ice in the surrounding highlands. An overall decrease in local water availability is observed from the profile base to top. Fluctuations in available water seem to be primarily governed by changes in local summer insolation controlled by the orbital eccentricity modulated by the precession cycle, and by changes in precipitation and temperature seasonality.

    Our record is roughly consistent with long-term climatic fluctuations in northeastern Mediterranean lands, except during the penultimate glacial phase. It shares some features with speleothem records of western Israel. Conversely, after 130 ka, it is clearly out of phase with hydrological changes in the Dead Sea basin. Potential causes of these spatial heterogeneities

  5. 30 CFR 250.192 - What reports and statistics must I submit relating to a hurricane, earthquake, or other natural...

    Science.gov (United States)

    2010-07-01

    ... submitting your statistics by fax or e-mail, you may submit them electronically in accordance with 30 CFR 250... electronically in accordance with 30 CFR 250.186(a)(3). In the report, you must: (i) Name the items damaged (e.g... relating to a hurricane, earthquake, or other natural occurrence? 250.192 Section 250.192 Mineral...

  6. Target Space $\

    CERN Document Server

    Huggett, Nick

    2015-01-01

    This paper investigates the significance of T-duality in string theory: the indistinguishability with respect to all observables, of models attributing radically different radii to space -- larger than the observable universe, or far smaller than the Planck length, say. Two interpretational branch points are identified and discussed. First, whether duals are physically equivalent or not: by considering a duality of the familiar simple harmonic oscillator, I argue that they are. Unlike the oscillator, there are no measurements 'outside' string theory that could distinguish the duals. Second, whether duals agree or disagree on the radius of 'target space', the space in which strings evolve according to string theory. I argue for the latter position, because the alternative leaves it unknown what the radius is. Since duals are physically equivalent yet disagree on the radius of target space, it follows that the radius is indeterminate between them. Using an analysis of Brandenberger and Vafa (1989), I explain wh...

  7. 76 FR 30294 - Special Conditions: Gulfstream Aerospace LP (GALP) Model G250 Airplane Pilot Compartment View...

    Science.gov (United States)

    2011-05-25

    ... INFORMATION CONTACT: Loran Haworth, Transport Airplane Directorate, Aircraft Certification Service, 1601 Lind... type certificate for their new Model G250 airplane. The G250 is an 8-10 passenger (19 maximum), twin... nautical miles. Airplane dimensions are 61.69-foot wing span, 66.6-foot overall length, and 20.8-foot...

  8. 30 CFR 250.1628 - Design, installation, and operation of production systems.

    Science.gov (United States)

    2010-07-01

    ... production systems. 250.1628 Section 250.1628 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF... Analysis Checklists are included in API RP 14C, you must use the analysis technique and documentation..., ceiling, walls (e.g., grating or solid), and firewalls; and (iii) Elementary electrical schematic of...

  9. 30 CFR 250.802 - Design, installation, and operation of surface production-safety systems.

    Science.gov (United States)

    2010-07-01

    ... production-safety systems. 250.802 Section 250.802 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT... Analysis Checklists are included in API RP 14C you must utilize the analysis technique and documentation...., type cable, conduit, or wire). (ii) Elementary electrical schematic of any platform safety...

  10. 17 CFR 250.8 - Exemption of subsidiaries subject to jurisdiction of Interstate Commerce Commission.

    Science.gov (United States)

    2010-04-01

    ... subject to jurisdiction of Interstate Commerce Commission. 250.8 Section 250.8 Commodity and Securities... to jurisdiction of Interstate Commerce Commission. Any subsidiary company of a registered holding company, which subsidiary is subject to the jurisdiction of the Interstate Commerce Commission but is...

  11. 30 CFR 250.520 - When do I have to perform a casing diagnostic test?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When do I have to perform a casing diagnostic test? 250.520 Section 250.520 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas...

  12. 30 CFR 250.447 - When must I pressure test the BOP system?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When must I pressure test the BOP system? 250.447 Section 250.447 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling...

  13. 30 CFR 250.426 - What are the recordkeeping requirements for casing and liner pressure tests?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the recordkeeping requirements for casing and liner pressure tests? 250.426 Section 250.426 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil...

  14. 30 CFR 250.525 - What do I submit if my casing diagnostic test requires action?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What do I submit if my casing diagnostic test requires action? 250.525 Section 250.525 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas...

  15. 30 CFR 250.1151 - How often must I conduct well production tests?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How often must I conduct well production tests? 250.1151 Section 250.1151 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas...

  16. 30 CFR 250.460 - What are the requirements for conducting a well test?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the requirements for conducting a well test? 250.460 Section 250.460 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling...

  17. 30 CFR 250.115 - How do I determine well producibility?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I determine well producibility? 250.115 Section 250.115 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND... well is an oil well, you must conduct a production test that lasts at least 2 hours after...

  18. 30 CFR 250.516 - Blowout preventer system tests, inspections, and maintenance.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Blowout preventer system tests, inspections, and maintenance. 250.516 Section 250.516 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and...

  19. 30 CFR 250.1508 - What must I do when MMS administers written or oral tests?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I do when MMS administers written or oral tests? 250.1508 Section 250.1508 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Well Control...

  20. 30 CFR 250.427 - What are the requirements for pressure integrity tests?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the requirements for pressure integrity tests? 250.427 Section 250.427 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas...

  1. 30 CFR 250.1153 - When must I conduct a static bottomhole pressure survey?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When must I conduct a static bottomhole pressure survey? 250.1153 Section 250.1153 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas...

  2. 30 CFR 250.425 - What are the requirements for pressure testing liners?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the requirements for pressure testing liners? 250.425 Section 250.425 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling...

  3. 30 CFR 250.423 - What are the requirements for pressure testing casing?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the requirements for pressure testing casing? 250.423 Section 250.423 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling...

  4. 30 CFR 250.616 - Blowout preventer system testing, records, and drills.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Blowout preventer system testing, records, and drills. 250.616 Section 250.616 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas...

  5. 30 CFR 250.448 - What are the BOP pressure tests requirements?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the BOP pressure tests requirements? 250.448 Section 250.448 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling...

  6. 30 CFR 250.407 - What tests must I conduct to determine reservoir characteristics?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What tests must I conduct to determine reservoir characteristics? 250.407 Section 250.407 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil...

  7. 30 CFR 250.527 - What must I include in my casing pressure request?

    Science.gov (United States)

    2010-07-01

    ... and the calculated daily production rate during last well test (oil, gas, basic sediment, and water... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I include in my casing pressure request? 250.527 Section 250.527 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE...

  8. 30 CFR 250.522 - When do I have to repeat casing diagnostic testing?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When do I have to repeat casing diagnostic testing? 250.522 Section 250.522 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas...

  9. 30 CFR 250.434 - What are the recordkeeping requirements for diverter actuations and tests?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the recordkeeping requirements for diverter actuations and tests? 250.434 Section 250.434 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil...

  10. 30 CFR 250.1152 - How do I conduct well tests?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I conduct well tests? 250.1152 Section 250.1152 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Production Requirements...

  11. 7 CFR 250.59 - Storage and inventory management of donated foods.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Storage and inventory management of donated foods. 250... National School Lunch Program (NSLP) and Other Child Nutrition Programs § 250.59 Storage and inventory management of donated foods. (a) General requirements. Distributing agencies, subdistributing agencies,...

  12. 30 CFR 250.241 - What must the DPP or DOCD include?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must the DPP or DOCD include? 250.241 Section 250.241 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND... facilities, umbilicals, and other facilities you will use to conduct your proposed development and...

  13. 17 CFR 250.80 - Definitions of terms used in rules under section 13.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Definitions of terms used in rules under section 13. 250.80 Section 250.80 Commodity and Securities Exchanges SECURITIES AND EXCHANGE..., marketing, auditing, statistical, advertising, publicity, tax, research, or any other service...

  14. 11 CFR 116.12 - Repayment of candidate loans of $250,000 or less.

    Science.gov (United States)

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Repayment of candidate loans of $250,000 or less. 116.12 Section 116.12 Federal Elections FEDERAL ELECTION COMMISSION GENERAL DEBTS OWED BY CANDIDATES AND POLITICAL COMMITTEES § 116.12 Repayment of candidate loans of $250,000 or less. (a)...

  15. 30 CFR 250.1158 - How do I receive approval to downhole commingle hydrocarbons?

    Science.gov (United States)

    2010-07-01

    ... hydrocarbons? 250.1158 Section 250.1158 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... hydrocarbons? (a) Before you perforate a well, you must request and receive approval from the Regional Supervisor to commingle hydrocarbons produced from multiple reservoirs within a common wellbore. The...

  16. 30 CFR 250.1506 - How often must I train my employees?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How often must I train my employees? 250.1506... Training § 250.1506 How often must I train my employees? You determine the frequency of the training you provide your employees. You must do all of the following: (a) Provide periodic training to ensure...

  17. 30 CFR 250.1505 - Where may I get training for my employees?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Where may I get training for my employees? 250... Safety Training § 250.1505 Where may I get training for my employees? You may get training from any source that meets the requirements of your training plan....

  18. 7 CFR 250.58 - Ordering donated foods and their provision to school food authorities.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Ordering donated foods and their provision to school food authorities. 250.58 Section 250.58 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND...

  19. 30 CFR 250.410 - How do I obtain approval to drill a well?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I obtain approval to drill a well? 250... OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.410 How do I obtain approval to drill a well? You must obtain...

  20. 30 CFR 250.1160 - When may I flare or vent gas?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When may I flare or vent gas? 250.1160 Section... GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Production Requirements Flaring, Venting, and Burning Hydrocarbons § 250.1160 When may I flare or vent gas? (a) You must request...

  1. 40 CFR 436.250 - Applicability; description of the jade subcategory.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Applicability; description of the jade subcategory. 436.250 Section 436.250 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS MINERAL MINING AND PROCESSING POINT SOURCE CATEGORY Jade...

  2. 21 CFR 107.250 - Termination of an infant formula recall.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Termination of an infant formula recall. 107.250... (CONTINUED) FOOD FOR HUMAN CONSUMPTION INFANT FORMULA Infant Formula Recalls § 107.250 Termination of an infant formula recall. The recalling firm may submit a recommendation for termination of the recall...

  3. 30 CFR 250.1752 - How do I remove a pipeline?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I remove a pipeline? 250.1752 Section... GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Decommissioning Activities Pipeline Decommissioning § 250.1752 How do I remove a pipeline? Before removing a pipeline, you must: (a) Submit a...

  4. 30 CFR 250.297 - What information must a CID contain?

    Science.gov (United States)

    2010-07-01

    ... cross sections and corresponding interpreted seismic lines or block diagrams, as necessary, that include... producibility requirements of § 250.115 or § 250.116: (1) General discussion of the overall development of the..., specified by date, and whether estimated or measured; (13) Description of reservoir development...

  5. 33 CFR 96.250 - What documents and reports must a safety management system have?

    Science.gov (United States)

    2010-07-01

    ... requirements are carried out by the vessel's crew and shore-based resources; and (5) Review the safety... pollution prevention activities (1) Periodic evaluation of the safety management system's efficiency and... safety management system have? 96.250 Section 96.250 Navigation and Navigable Waters COAST...

  6. 30 CFR 250.243 - What general information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What general information must accompany the DPP or DOCD? 250.243 Section 250.243 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Contents of Development and Production Plans (dpp) and Development Operations Coordination Documents...

  7. 48 CFR 250.104-3 - Special procedures for unusually hazardous or nuclear risks.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Special procedures for unusually hazardous or nuclear risks. 250.104-3 Section 250.104-3 Federal Acquisition Regulations System... unusually hazardous or nuclear risks....

  8. 7 CFR 250.61 - Child and Adult Care Food Program (CACFP).

    Science.gov (United States)

    2010-01-01

    ... Section 250.61 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION DONATION OF FOODS... National School Lunch Program (NSLP) and Other Child Nutrition Programs § 250.61 Child and Adult Care...

  9. 30 CFR 250.455 - What are the general requirements for a drilling fluid program?

    Science.gov (United States)

    2010-07-01

    ... well control. This program must address drilling fluid safe practices, testing and monitoring equipment... drilling fluid program? 250.455 Section 250.455 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil...

  10. 30 CFR 250.424 - What are the requirements for prolonged drilling operations?

    Science.gov (United States)

    2010-07-01

    ... the prolonged operations on continued drilling operations and the life of the well. At a minimum, you... drilling operations? 250.424 Section 250.424 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and...

  11. 41 CFR 60-250.25 - Health insurance, life insurance and other benefit plans.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Health insurance, life insurance and other benefit plans. 60-250.25 Section 60-250.25 Public Contracts and Property Management..., life insurance and other benefit plans. (a) An insurer, hospital, or medical service company,...

  12. 40 CFR 421.250 - Applicability: Description of the primary precious metals and mercury subcategory.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Applicability: Description of the primary precious metals and mercury subcategory. 421.250 Section 421.250 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS...

  13. 40 CFR 147.250 - State-administered program-Class II wells.

    Science.gov (United States)

    2010-07-01

    ... State of California, except those on Indian lands, is the program administered by the California... 40 Protection of Environment 22 2010-07-01 2010-07-01 false State-administered program-Class II wells. 147.250 Section 147.250 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY...

  14. Investigation of Fast Neutron Production by 100 to 250~GeV Muon Interactions on Thin Targets

    CERN Multimedia

    2002-01-01

    % NA55 \\\\ \\\\ The production of fast (1~MeV~-~1~GeV) neutrons in high energy muon-nucleon interactions is poorly understood. Yet it is essential to the understanding of the background in many underground neutrino experiments and, in particular, may hold relevance for the atmospheric neutrino anomaly. We propose an experiment to investigate fast neutron production using the M2 muon beam at the CERN SPS.

  15. The multiplicity of 250-$\\mu$m Herschel sources in the COSMOS field

    CERN Document Server

    Scudder, Jillian M; Hurley, Peter D; Griffin, Matt; Sargent, Mark T; Scott, Douglas; Wang, Lingyu; Wardlow, Julie L

    2016-01-01

    We investigate the multiplicity of extragalactic sources detected by the Herschel Space Observatory in the COSMOS field. Using 3.6- and 24-$\\mu$m catalogues, in conjunction with 250-$\\mu$m data from Herschel, we seek to determine if a significant fraction of Herschel sources are composed of multiple components emitting at 250 $\\mu$m. We use the XID+ code, using Bayesian inference methods to produce probability distributions of the possible contributions to the observed 250-$\\mu$m flux for each potential component. The fraction of Herschel flux assigned to the brightest component is highest for sources with total 250-$\\mu$m fluxes < 45 mJy; however, the flux in the brightest component is still highest in the brightest Herschel sources. The faintest 250-$\\mu$m sources (30-45 mJy) have the majority of their flux assigned to a single bright component; the second brightest component is typically significantly weaker, and contains the remainder of the 250-$\\mu$m source flux. At the highest 250-$\\mu$m fluxes (45-...

  16. The expected radiation damage of CSNS target

    Science.gov (United States)

    Yin, W.; Yu, Q. Z.; Lu, Y. L.; Wang, S. L.; Tong, J. F.; Liang, T. J.

    2012-12-01

    The radiation damage to the tungsten target and its SS316 vessel for Chinese Spallation Neutron Source (CSNS) has been estimated with a Monte-Carlo simulation code MCNPX2.5.0. We compare the effects on the radiation damage due to two different proton beam profiles: a uniform distribution and a Gaussian distribution. We also discuss the dependence of the radiation damage estimation on different physics models. The results show the peak displacement productions in vessel and the fourth target plate are 2.5 and 5.5 dpa/y, respectively, under a Gaussian proton beam. The peak helium productions in the vessel and the fourth target are 305 and 353 appm/y, respectively, under the same proton beam. Based on these results and the allowable dpa values we have estimated the lifetime of the tungsten target and its vessel.

  17. Pulverização em CDA 250 herbicida pendimethalin na cultura do arroz de sequeiro Application of pendimethalin with cda 250 spfayer for upland rice

    Directory of Open Access Journals (Sweden)

    T. Matuo

    1984-01-01

    Full Text Available Foi estudada a viabilidade de utilização da pulverização CDA 25C, na aplicação do herbicida em pré-emergência na cultura do arroz de sequeiro. O herbicida empregado foi o pendimethalin nas doses de 0,0; 1,5; 2,0; 2,5 e 3,0 litro s/ha da formulação comercial a 50%. A pulverização convencional foi efetuada com bicos 11003 com consumo de 200 litros de calda per hectare. O processo CDA 250 foi aplicado por meio de bico rotativo (Micromax com dois níveis de consumo de calda : 50 1/ha e 27 1/ha. Os resultados mostraram que: a - o método CDA 250 proporciona controle dc mato e produtividade de arroz equivalentes ao método convencional; b para o bico Micromax, a aplicação da formulação comercial de pendimethalin a 50% com vazão de 0,48 1/min./bico, a distância entre bicos deve ser de 1,75 m e para a vazão de 0,96 1/min./bloco, essa distancia deve ser de 1,90 m; c- a aplicação do pendimethalin 50% C.E. pelo processo CDA 250, empregando 27 litros de calda por hectare foi o processo mais interessante por oferecer vantagens logísticas apreciáveis.The feasibility of pre-emergenge herbicide application for upland rice by CDA 250 spray method was studied. The herbicide used was pen dimethalin at 0,0; 1,5; 2,0; 2,5 and 3,0 1/ha of comercial 50% E.C. formulation. Conventional spraying was carried out using 110C3 flat fan nozzles applying 200 1/ha of spray volume CDA250 was applied by rotary atomizers (Micromax spraying twc volume rates: 50 1/ha and 27 1/ha. The results pointed out that: a- CDA 250 spray method was equivalent to the conventional spray method in the control of weeds and crop yield; b - for Micromax nozzles applying commercial 50 E.C. formulation of pendimethalin at 0,48 /min of nozzle feed rate, the distance between nozzles should be 1,75 m and at 0,96 1/min feed rate this distance shoud be 1,90 m; c- CDA 250, applying 27 1/ha presents large logistic advantages.

  18. 解读2015年度ENR国际承包商250强%Analysis on the ENR Top 250 International Contractors in 2015

    Institute of Scientific and Technical Information of China (English)

    张宇

    2015-01-01

    Based on the results of the ENR top 250 international Contractors in 2015,the analysis on the 250 international contractors was conducted from the revenue outside of their home countries,the profitability,the professional hiring,regional and market distribution in 2014. In the context of the global politics and economics environment,the highlights and trend of the development of international contracting market were concluded. On the contractors from mainland China in top 250,the number, influence and distribution were emphasized and the comparison from the last 5 years was done both on the mainland Chinese contractors and the top 10 international contractors. By the evaluation on the performance of the 250 international contractors and the discuss on the international engineering market,the recognition on the global competition of the contractors in mainland China would be promoted and their improvement in international contracting market could get useful information.%以美国《工程新闻记录》发布的2015年度国际承包商250强榜单数据为基础,对进入榜单的250家承包商的海外市场收入总体规模、效益、专业技术人员雇佣、业务领域分布、区域性市场及所属国家或地区进行了剖析.结合近期国际经济政治环境,对国际承包市场发展特征及趋势进行了总结和概括.重点分析了本年度进入250强榜单的中国内地企业承包商的数量、影响和行业及地区分布,并对近5年中国内地企业的表现进行了对比分析,同时对近5年国际承包商10强的变化进行了梳理.通过对国际承包市场要素的分析及对主要承包商业绩的评价,为中国内地企业增强对国际竞争的认识,继续开拓国际工程承包市场提供基础信息支持.

  19. 1:250,000-scale geology of the Carson River Basin, Nevada and California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digital continuous geologic data for the Carson River Basin, Nevada and California. It was compiled from individual county 1:250,000-scale...

  20. 1:250,000-scale geology of the Dry Valley Hydrographic Area, Nevada and California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This dataset consists of digital geologic data for the Dry Valley Hydrographic area, Nevada and California. It was compiled from individual 1:250,000-scale geologic...

  1. 腺病毒介导G250基因转染树突状细胞激活免疫效应细胞治疗肾癌的实验研究%Experimental study of transfecting adenovirus carrying G250 antigen gene to dendritic cells and to activate immune effector cells in kidney cancer treatment

    Institute of Scientific and Technical Information of China (English)

    齐桓; 郑少斌

    2010-01-01

    Objective To investigate T cell-mediated effects of dendritic cells(DC)transfected with kidney associated antigen G250 gene using adenovirus(Ad)as vector in the treatment of kidney cancer. Methods Peripheral blood mononuclear cells(PBMC)were isolated by standard FicollPaque density gradient centrifugation of heparinized blood obtained from healthy donors.After removal of the nonadherent ceils,the adherent cells were divided into gene transfer group,protein pulsed group and control group.The gene transfer group was infected with Ad/G250 virus;the protein pulsed group was added with G250 protein; the control group was added with PBS.The DCs were cultured and proliferated in vitro using recombinant human granulocyte macrophage colony stimulating factor and inlerleukin-4.The autologous T cells were added into the 3 DC groups(responders:dendritics,20:1).After 5 d co-culture,3 eytotoxic T lymphocyte(CTL)groups were collected.TheG250 mRNA expression was detected in transduced DCs using RT-PCR.The G250 protein translation products and cell surface marker of DCs were analyzed by flow cytometry.The specific cytolytic activities of CTL to different target cells(renal carcinoma 786-0 cell line and lung cancer A549 cell line)were assessed by MTT method. Results Ad/G250 transfected DC successfully and the G250 expression was confirmed by RT-PCR. The expression levels of CD_(80), CD_(83). HLA-DR and CD_(86) in the Ad/G250 group were higher than those in the other 2 groups. The cytotoxicity to 786-0 of T lymphocytes activated by Ad/G250 transfecting DCs(83. 4±2. 8)% was greater than those of T lymphocytes in the protein pulsed group(79. 6±2. 4)% and control group(77. 3±2. 1)%. There were no significant differences of the cytotyxicities to A549 among the 3 cytotoxic T lymphocyte groups(F=0. 373.P=0.693). Conclusions Ad-loading DCs may be useful for immunotherapeutic protocols against self-antigens for the kidney cancer.%目的 探讨以腺病毒(Ad)载

  2. A critical ('stress') evaluation of the combined ML Copper 250-short IUD in nulliparous women.

    Science.gov (United States)

    Goldstuck, N D

    1981-10-01

    IUD tolerability is related to the size and shape of the carrier frame of the copper-containing IUD. This study evaluates a critically selected group of 30 nulliparous women (those with uterine cavity length of 3.5 cm or less) who underwent insertion of the combined Multiload Copper 250-short (ML Cu 250-short) IUD. The women were aged 18 to 36 years. They were followed up between 6 months and 1 year. 1 patient with a very small infantile uterus (3.5 cm) had 2 IUD insertions and expulsions and was deemed not fit for intrauterine contraception. Another patient requested removal because of persistent bleeding, probably due to a fragile endometrium or a local bleeding disorder. 6 patients (20%) reported pre- and inter-menstrual pain, while 12 (40%) patients, including the patient who requested device removal, complained of prolonged bleeding following insertion of the ML Cu 250-short. Bleeding continued in majority of the cases for about 14 days following insertion. The bleeding pattern returned to normal after 2 months. No infections or pregnancies were reported. 4 of the patients who continued to use the device experienced some pain and/or discomfort. None of the patients who had experienced pain with previous devices experienced pain with the ML Cu 250-short. The length and width of the ML Cu 250-short appears optimal for the endometrial cavity of nulliparous women. The horizontal width of the ML Cu 250-short (18 mm) most closely approximates the 20 mm nulliparous uterine cavity width while the ML Cu 250-mini with a fundal horizontal length of 12 mm appears destined for use only by women with very narrow uterus. Hassons' wing sound 11 allows clinical graphical representation of the uterine cavity, enabling the inserter to select anatomically optimal device immediately in the clinic. The ML Copper 250-short appears highly suitable for use by nulliparous women.

  3. Bioavailability study of calcium sandoz-250 by atomic absorption spectroscopy in albino rats

    OpenAIRE

    Patel, Bimalkumar N.; Krishnaveni, N.; Jivani, Nurrrudin P.; Khodakiya, Akruti S.; Khodakiya, Moorti S.; Parida, Saswat K.

    2014-01-01

    Background: Calcium sandoz-250 is an Ayurvedic calcium supplement, containing Khatika Churna. Bioavailability study of the formulation is essential for estimation of peak plasma concentration (C max), time to C max and rate of absorption. Aim: To evaluate the absorption parameters of calcium sandoz-250 in albino rats by atomic absorption spectroscopic (AAS) method. Materials and Methods: Study was carried out as a single dose, open-label, randomized study. Estimation of calcium was carried ou...

  4. Galvanic corrosion behaviour of HE 20 / MDN 138 & HE 20 / MDN 250 alloys in natural seawater

    Science.gov (United States)

    Subramanian, G.; Parthiban, G. T.; Muthuraman, K.; Ramakrishna rao, P.

    2016-09-01

    In view of their excellent mechanical properties, workability and heat treatment characteristics, MDN 138 & MDN 250 have been widely used in missile, rocket and aerospace industries. With light weight and high performance characteristics HE 20 aluminium alloy acts as an important material in defence and aerospace applications. The galvanic corrosion behaviour of the metal combinations HE 20 / MDN 138 and HE 20 / MDN 250, with 1:1 area ratio, has been studied in natural seawater using the open well facility of CECRI's Offshore Platform at Tuticorin for a year. The open circuit potentials of MDN 138, MDN 250 and HE 20 of the individual metal, the mixed potential and galvanic current of the couples HE 20 / MDN 138 and HE 20 / MDN 250 were periodically monitored throughout the study period. The calcareous deposits on MDN 138 and MDN 250 were analysed using XRD. The results of the study reveal that that HE 20 has offered required amount of protection to MDN 138 & MDN 250.

  5. Transmission of the P250R mutation of the FGFR3 gene in four generations with highly variable phenotype

    DEFF Research Database (Denmark)

    Hove, Hanne Buciek; Dunø, Morten; Daugaard-Jensen, Jette;

    Transmission of the P250R mutation of the FGFR3 gene in four generations with highly variable phenotype.......Transmission of the P250R mutation of the FGFR3 gene in four generations with highly variable phenotype....

  6. 30 CFR 250.116 - How do I determine producibility if my well is in the Gulf of Mexico?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I determine producibility if my well is in the Gulf of Mexico? 250.116 Section 250.116 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General Performance Standards § 250.116 How do...

  7. 30 CFR 250.172 - When may the Regional Supervisor grant or direct an SOO or SOP?

    Science.gov (United States)

    2010-07-01

    ... direct an SOO or SOP? 250.172 Section 250.172 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT... Suspensions § 250.172 When may the Regional Supervisor grant or direct an SOO or SOP? The Regional Supervisor may grant or direct an SOO or SOP under any of the following circumstances: (a) When necessary...

  8. 30 CFR 250.445 - What are the requirements for kelly valves, inside BOPs, and drill-string safety valves?

    Science.gov (United States)

    2010-07-01

    ...). You must be able to strip the lower kelly valve through the BOP stack; (c) If you drill with a mud..., inside BOPs, and drill-string safety valves? 250.445 Section 250.445 Mineral Resources MINERALS... CONTINENTAL SHELF Oil and Gas Drilling Operations Blowout Preventer (bop) System Requirements § 250.445...

  9. 30 CFR 250.1163 - How must I measure gas flaring or venting volumes and liquid hydrocarbon burning volumes, and...

    Science.gov (United States)

    2010-07-01

    ... volumes and liquid hydrocarbon burning volumes, and what records must I maintain? 250.1163 Section 250..., and Burning Hydrocarbons § 250.1163 How must I measure gas flaring or venting volumes and liquid hydrocarbon burning volumes, and what records must I maintain? (a) If your facility processes more than...

  10. 30 CFR 250.107 - What must I do to protect health, safety, property, and the environment?

    Science.gov (United States)

    2010-07-01

    ..., property, and the environment? 250.107 Section 250.107 Mineral Resources MINERALS MANAGEMENT SERVICE... Performance Standards § 250.107 What must I do to protect health, safety, property, and the environment? (a) You must protect health, safety, property, and the environment by: (1) Performing all operations in...

  11. 30 CFR 250.1006 - How must I decommission and take out of service a DOI pipeline?

    Science.gov (United States)

    2010-07-01

    ... a DOI pipeline? 250.1006 Section 250.1006 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Pipelines and Pipeline Rights-of-Way § 250.1006 How must I decommission and take out of service a DOI...

  12. 40 CFR 408.250 - Applicability; description of the Pacific Coast hand-shucked oyster processing subcategory.

    Science.gov (United States)

    2010-07-01

    ... Pacific Coast hand-shucked oyster processing subcategory. 408.250 Section 408.250 Protection of... SEAFOOD PROCESSING POINT SOURCE CATEGORY Pacific Coast Hand-Shucked Oyster Processing Subcategory § 408.250 Applicability; description of the Pacific Coast hand-shucked oyster processing subcategory....

  13. 30 CFR 250.245 - What hydrogen sulfide (H2S) information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What hydrogen sulfide (H2S) information must accompany the DPP or DOCD? 250.245 Section 250.245 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT... Documents (docd) § 250.245 What hydrogen sulfide (H2S) information must accompany the DPP or DOCD?...

  14. 30 CFR 250.260 - What Coastal Zone Management Act (CZMA) information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ...) information must accompany the DPP or DOCD? 250.260 Section 250.260 Mineral Resources MINERALS MANAGEMENT... Operations Coordination Documents (docd) § 250.260 What Coastal Zone Management Act (CZMA) information must.... “Information” as required by 15 CFR 930.76(a) and 15 CFR 930.58(a)(2)) and “Analysis” as required by 15 CFR...

  15. Low Cycle Fatigue Behavior of HT250 Gray Cast Iron for Engine Cylinder Blocks

    Science.gov (United States)

    Fan, K. L.; He, G. Q.; She, M.; Liu, X. S.; Yang, Y.; Lu, Q.; shen, Y.; Tian, D. D.

    2014-08-01

    The strain-controlled low cycle fatigue properties were evaluated on specimens of HT250 gray cast iron (GCI) at room temperature. The material exhibited cyclic stabilization at a low strain amplitude of 0.1% and cyclic softening characteristic at higher strain amplitudes (0.15-0.30%). At a representative total strain amplitude (0.30%), the hysteresis loops of HT250 GCI were asymmetric with a large amount of plastic deformation in the compressive phases. Furthermore, the hysteresis loop became larger in both width and height with increasing total strain amplitude (from 0.10 to 0.30%), and tended to exhibit a clockwise rotation. The fatigue crack propagation mechanisms were different at various total strain amplitudes, where high stress concentration due to dislocation pile-up favored fatigue crack initiation in the examined HT250. Finally, the roughness-induced crack closure was a key to determine the crack growth rate as well as fatigue life.

  16. The faint end of the 250 micron luminosity function at z < 0.5

    CERN Document Server

    Wang, L; Bethermin, M; Bourne, N; Cooray, A; Cowley, W; Dunne, L; Dye, S; Eales, S; Farrah, D; Lacey, C; Loveday, J; Maddox, S; Oliver, S; Viero, M

    2016-01-01

    Aims. We aim to study the 250 micron luminosity function (LF) down to much fainter luminosities than achieved by previous efforts. Methods. We developed a modified stacking method to reconstruct the 250 micron LF using optically selected galaxies from the SDSS survey and Herschel maps of the GAMA equatorial fields and Stripe 82. Our stacking method not only recovers the mean 250 micron luminosities of galaxies that are too faint to be individually detected, but also their underlying distribution functions. Results. We find very good agreement with previous measurements in the overlapping luminosity range. More importantly, we are able to derive the LF down to much fainter luminosities (around 25 times fainter) than achieved by previous studies. We find strong positive luminosity evolution \\propto (1 + z)^4.89\\pm1.07 and moderate negative density evolution \\propto (1 + z)^-1.02\\pm0.54 over the redshift range z=[0.02, 0.5].

  17. Accumulation and temperature changes in Princess Elizabeth Land, Antarctica in the past 250 years

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A 50 m firn core drilled in Princess Elizabeth Land, Antarctica, during the 1996/1997 Chinese First Antarctic Inland Expedition, has been measured for б18O and major ions. Based on these data, the features of the climate change in the investigated region in the past 250 years have first been studied. In the past 250 years, the change trend of climate in this region can be divided into two periods by the year 1860. Both the temperature and accumulation rate display increasing trend before 1860, while after 1860, the decreasing trend of the temperature is obvious but the change of the accumulation rate is not clear. Although both the temperature and the accumulation rate are increasing in the past 50 years, they are not the highest values in the past 250 years. So it is clear that the climate change in this region during this period does not reflect recent global wanning.

  18. A physically based approach to model LAI from MODIS 250 m data in a tropical region

    Science.gov (United States)

    Propastin, Pavel; Erasmi, Stefan

    2010-02-01

    A time series of leaf area index (LAI) has been developed based on 16-day normalized difference vegetation index (NDVI) data from the Moderate Resolution Imaging Spectroradiometer (MODIS) at 250 m resolution (MOD250_LAI). The MOD250_LAI product uses a physical radiative transfer model which establishes a relationship between LAI, fraction of vegetation cover (FVC) and given patterns of surface reflectance, view-illumination conditions and optical properties of vegetation. In situ measurements of LAI and FVC made at 166 plots using hemispherical photography served for calibration of model parameters and validation of modelling results. Optical properties of vegetation cover, summarized by the light extinction coefficient, were computed at the local (pixel) level based on empirical models between ground-measured tree crown architecture at 85 sampling plots and spectral values in Landsat ETM+ bands. Influence of view-illumination conditions on optical properties of canopy was simulated by a view angle geometry model incorporating the solar zenith angle and the sensor viewing angle. The results revealed high compatibility of the produced MOD250_LAI data set with ground truth information and the 30 m resolution Landsat ETM+ LAI estimated using the similar algorithm. The produced MOD250_LAI was also compared with the global MODIS 1000-m LAI product (MOD15A2 LAI). Results show good consistency of the spatial distribution and temporal dynamics between the two LAI products. However, the results also showed that the annual LAI amplitude by the MOD15A2 product is significantly higher than by the MOD250_LAI. This higher amplitude is caused by a considerable underestimation of the tropical rainforest LAI by the MOD15A2 during the seasonal phases of low leaf production.

  19. The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits.

    Directory of Open Access Journals (Sweden)

    Kazutaka Ohi

    Full Text Available BACKGROUND: Hypofunction of the glutamate N-Methyl-d-aspartate (NMDA receptor has been implicated in the pathophysiology of schizophrenia. p250GAP is a brain-enriched NMDA receptor-interacting RhoGAP. p250GAP is involved in spine morphology, and spine morphology has been shown to be altered in the post-mortem brains of patients with schizophrenia. Schizotypal personality disorder has a strong familial relationship with schizophrenia. Several susceptibility genes for schizophrenia have been related to schizotypal traits. METHODS: We first investigated the association of eight linkage disequilibrium-tagging single-nucleotide polymorphisms (SNPs that cover the p250GAP gene with schizophrenia in a Japanese sample of 431 schizophrenia patients and 572 controls. We then investigated the impact of the risk genetic variant in the p250GAP gene on schizotypal personality traits in 180 healthy subjects using the Schizotypal Personality Questionnaire. RESULTS: We found a significant difference in genotype frequency between the patients and the controls in rs2298599 (χ(2 = 17.6, p = 0.00015. The minor A/A genotype frequency of rs2298599 was higher in the patients (18% than in the controls (9% (χ(2 = 15.5, p = 0.000083. Moreover, we found that subjects with the rs2298599 risk A/A genotype, compared with G allele carriers, had higher scores of schizotypal traits (F(1,178 = 4.08, p = 0.045, particularly the interpersonal factor (F(1,178 = 5.85, p = 0.017. DISCUSSION: These results suggest that a genetic variation in the p250GAP gene might increase susceptibility not only for schizophrenia but also for schizotypal personality traits. We concluded that the p250GAP gene might be a new candidate gene for susceptibility to schizophrenia.

  20. Making Planet Nine: Pebble Accretion at 250--750 AU in a Gravitationally Unstable Ring

    CERN Document Server

    Kenyon, Scott J

    2016-01-01

    We investigate the formation of icy super-Earth mass planets within a gravitationally unstable ring of solids orbiting at 250-750 AU around a 1 solar mass star. Coagulation calculations demonstrate that a system of a few large oligarchs and a swarm of pebbles generates a super-Earth within 100-200 Myr at 250 AU and within 1-2 Gyr at 750 AU. Systems with more than ten oligarchs fail to yield super-Earths over the age of the solar system. As these systems evolve, destructive collisions produce detectable debris disks with luminosities of $10^{-5}$ to $10^{-3}$ relative to the central star.

  1. 从"250定律"谈银行服务的重要性%On Importance of Banking Services From "Law 250"

    Institute of Scientific and Technical Information of China (English)

    张福军; 胡世翠

    2004-01-01

    @@ "250定律"是美国著名汽车推销员乔·吉拉德总结归纳的一条营销定律.乔·吉拉德在连续12年内以平均每天销售6辆车的营销成绩荣登世界销售第一的宝座,他所保持的汽车日均销售记录,至今无人能破.

  2. Clovis, NM TX 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  3. 30 CFR 250.246 - What mineral resource conservation information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What mineral resource conservation information... Coordination Documents (docd) § 250.246 What mineral resource conservation information must accompany the DPP or DOCD? The following mineral resource conservation information, as applicable, must accompany...

  4. Raton, NM CO 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  5. Tularosa, NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  6. 20 CFR 411.250 - How will SSA evaluate a PM?

    Science.gov (United States)

    2010-04-01

    ...) Business relations; and (5) Customer satisfaction. (b) Our Project Officer will perform the evaluation. The PM will have an opportunity to comment on the evaluation, and then the Contracting Officer will... Evaluation of Program Manager Performance § 411.250 How will SSA evaluate a PM? (a) We will...

  7. 7 CFR 250.51 - Crediting for, and use of, donated foods.

    Science.gov (United States)

    2010-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION DONATION OF FOODS... Foods in Contracts With Food Service Management Companies § 250.51 Crediting for, and use of, donated... service management company must credit the recipient agency for the value of all donated foods...

  8. 7 CFR 250.52 - Storage and inventory management of donated foods.

    Science.gov (United States)

    2010-01-01

    ... NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION DONATION OF... Donated Foods in Contracts With Food Service Management Companies § 250.52 Storage and inventory management of donated foods. (a) General requirements. The food service management company must meet...

  9. Santa Fe, NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  10. Douglas, AZ NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  11. Gallup, NM AZ 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  12. Hobbs, NM TX 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  13. Fort Sumner, NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  14. Aztec, NM CO 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  15. 30 CFR 250.223 - What mitigation measures information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What mitigation measures information must... INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Plans and Information Contents of Exploration Plans (ep) § 250.223 What mitigation measures information must accompany the EP?...

  16. 30 CFR 250.254 - What mitigation measures information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What mitigation measures information must... Information Contents of Development and Production Plans (dpp) and Development Operations Coordination Documents (docd) § 250.254 What mitigation measures information must accompany the DPP or DOCD? (a) If...

  17. 7 CFR 250.60 - Use of donated foods in the school food service.

    Science.gov (United States)

    2010-01-01

    ... National School Lunch Program (NSLP) and Other Child Nutrition Programs § 250.60 Use of donated foods in...: (1) School breakfasts or other meals served in child nutrition programs; (2) A la carte foods sold to... food service, and to other school staff; and (4) Training in nutrition, health, food service,...

  18. 50 CFR 216.250 - Specified activity and specified geographical region.

    Science.gov (United States)

    2010-10-01

    ... OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE... Weapon Missions in the Gulf of Mexico § 216.250 Specified activity and specified geographical region. (a... within the Eglin Air Force Base Gulf Test and Training Range within the northern Gulf of Mexico....

  19. 7 CFR 250.64 - Food Distribution Program in the Trust Territory of the Pacific Islands.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Food Distribution Program in the Trust Territory of... DISTRIBUTION DONATION OF FOODS FOR USE IN THE UNITED STATES, ITS TERRITORIES AND POSSESSIONS AND AREAS UNDER ITS JURISDICTION Household Programs § 250.64 Food Distribution Program in the Trust Territory of...

  20. 24 CFR 92.250 - Maximum per-unit subsidy amount and subsidy layering.

    Science.gov (United States)

    2010-04-01

    ... of Housing and Urban Development HOME INVESTMENT PARTNERSHIPS PROGRAM Project Requirements § 92.250... the National Housing Act (12 U.S.C. 17151(d)(3)(ii)) for elevator-type projects that apply to the area... project, the participating jurisdiction must evaluate the project in accordance with guidelines that...

  1. 30 CFR 250.218 - What air emissions information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... when applicable, nitrogen oxides (NOX), carbon monoxide (CO), and volatile organic compounds (VOC) that... modeling, you must use the guidelines in Appendix W of 40 CFR part 51 with a model approved by the Director...) Modeling report. A modeling report or the modeling results (if § 250.303 requires you to use an...

  2. 12 CFR 250.403 - Service of member bank and real estate investment company.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Service of member bank and real estate... Glass-Steagall Act § 250.403 Service of member bank and real estate investment company. (a) The Board recently considered two inquiries regarding the question whether proposed real estate investment...

  3. 30 CFR 250.901 - What industry standards must your platform meet?

    Science.gov (United States)

    2010-07-01

    ..., Building Code Requirements for Reinforced Concrete (ACI 318-95) and Commentary (ACI 318R-95) (incorporated..., Specification for Structural Steel Buildings, (incorporated by reference as specified in § 250.198); (4...); (22) AWS D3.6M, Specification for Underwater Welding, (incorporated by reference as specified in §...

  4. [Kinetics of serum albumin adsorption on the macroporous glass MPS-250 GKH].

    Science.gov (United States)

    Naumova, L V; El'Kin, G E; Dmitrenko, L V

    1996-01-01

    Intrinsic diffusion (defined as diffusion within micropores or microgranules) was shown to be a major factor that determines the kinetics of bovine serum albumin adsorption to macroporous silica MPS-250 GKh. The effective coefficient of intrinsic diffusion (within the silica phase) was calculated (Def = 7 x 10(-7) cm2/s).

  5. 30 CFR 250.1162 - When may I burn produced liquid hydrocarbons?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When may I burn produced liquid hydrocarbons... Requirements Flaring, Venting, and Burning Hydrocarbons § 250.1162 When may I burn produced liquid hydrocarbons... hydrocarbons. The Regional Supervisor may allow you to burn liquid hydrocarbons if you demonstrate...

  6. Muusikamaailm. Maailmaesiettekanne Krimmis. Herderi preemiad 2002. Opera Metz 250. Günter Wand 90 / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2002-01-01

    Krimmis leiab aset Alemdar Karamanovi sümfoonia "Täideläinu" maailma esiettekanne. Johann Gottfried Herderi muusikapreemia sai nimekas rumeenia helilooja Aurel Stroe. Opera Metz Prantsusmaal tähistab oma 250ndat aastapäeva mitmete uuslavastustega. Dirigent Günter Wand tähistab 90ndat juubelit

  7. 30 CFR 250.462 - What are the requirements for well-control drills?

    Science.gov (United States)

    2010-07-01

    ... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Other Drilling Requirements § 250.462 What are the requirements for well-control drills? You must conduct a weekly well-control drill with each drilling crew. Your drill must familiarize the crew with...

  8. 30 CFR 250.402 - When and how must I secure a well?

    Science.gov (United States)

    2010-07-01

    ... GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations General Requirements § 250.402 When and how must I secure a well? Whenever you interrupt drilling operations, you must...) Inability to keep the drilling rig on location; or (3) Repair to major drilling or well-control...

  9. 30 CFR 250.469 - What other well records could I be required to submit?

    Science.gov (United States)

    2010-07-01

    ... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Modify and Well Records § 250.469 What other well records could I be required to... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What other well records could I be required...

  10. 7 CFR 250.66 - Special Supplemental Nutrition Program for Women, Infants and Children.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Special Supplemental Nutrition Program for Women... ITS JURISDICTION Household Programs § 250.66 Special Supplemental Nutrition Program for Women, Infants... Special Supplemental Nutrition Program for Women, Infants and Children (WIC Program) under part 246...

  11. LCD OF AIR INTAKE MANIFOLDS PHASE 2: FORD F250 AIR INTAKE MANIFOLD

    Science.gov (United States)

    The life cycle design methodology was applied to the design analysis of three alternatives for the lower plehum of the air intake manifold for us with a 5.4L F-250 truck engine: a sand cast aluminum, a lost core molded nylon composite, and a vibration welded nylon composite. The ...

  12. 21 CFR 250.101 - Amphetamine and methamphetamine inhalers regarded as prescription drugs.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Amphetamine and methamphetamine inhalers regarded... DRUGS New Drug or Prescription Status of Specific Drugs § 250.101 Amphetamine and methamphetamine... and the methamphetamine they contain is being used as a substitute for amphetamine...

  13. Comparison of differences between MODIS 250 m and 1 km cloud masks

    Science.gov (United States)

    Kotarba, Andrzej Z.

    2016-11-01

    The spatial resolution of remote sensing instruments installed onboard satellites is one of the key factors for accurate estimations of cloud amount. In general terms, the larger the instantaneous field of view (IFOV), the greater the overestimation of cloud amount - assuming that data are collected with exactly the same methodology, and processed with exactly the same algorithms. While most meteorological imagers collect data at a spatial resolution of 1 km, the Moderate Resolution Imaging Spectroradiometer (MODIS) offers cloud amount estimates at both 1 km (the standard product) and 250 m (additional, high-resolution products). However, these datasets are produced using different methodological approaches, which impacts the quality and reliability of the product. This study compared 250 m data with 1 km data over elevated terrain with complex orography. Results showed significant discrepancies between the datasets, with 250 m data reporting mean seasonal (June-August) cloud amount 15.8% lower, than 1 km dataset. This was not related to the presence of snow, or to the increased spatial resolution of the cloud mask. On the other hand, both 1 km and 250 m data described similar spatial variability in mean monthly cloud amount (correlation coefficients of 0.85-0.98, p < 0.01).

  14. Silver City, NM AZ 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  15. 30 CFR 250.113 - What procedures must I follow when welding?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What procedures must I follow when welding? 250....113 What procedures must I follow when welding? (a) Before you weld, you must move any equipment containing hydrocarbons or other flammable substances at least 35 feet horizontally from the welding...

  16. 30 CFR 250.110 - What must I include in my welding plan?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I include in my welding plan? 250.110... must I include in my welding plan? You must include all of the following in the Welding Plan that you... qualified personnel weld; (c) Practices and procedures for safe welding that address: (1) Welding...

  17. 30 CFR 250.111 - Who oversees operations under my welding plan?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Who oversees operations under my welding plan... § 250.111 Who oversees operations under my welding plan? A welding supervisor or a designated person in charge must be thoroughly familiar with your welding plan. This person must ensure that each welder...

  18. Comparing the Effect of Different Bleaching Regims of Carbamide Peroxide on Microhardness of Z250 Composite

    Directory of Open Access Journals (Sweden)

    B Esmaeili

    2015-11-01

    Full Text Available Introduction: Bleaching products with oxidizing mechanism can exert side effects on the restorative materials existing in the oral cavity. Since bleaching agents are applied in different concentrations, the present study aimed to compare the effect of different bleaching regims of carbamide peroxide on microhardness of Z250 microhybride composite. Methods: In this in vitro study , 32 specimens of micro hybride composite (Z250 were made which were randomly divided into 4 subgroups (n=8: G1: bleached with10% carbamide peroxide 4 hours a day for 2 weeks G2: bleached with 16%carbamide peroxide 3 hours a day for 2 weeks G3: bleached with 22%carbamide peroxide 1hour a day for 2 weeks G4: the control subgroup stored in distilled water at 37◦c for 2 weeks. Microhardness of specimens was measured before and after bleaching using Vickers hardness testing machine. Moreover, the study data were analyzed statistically applying Anova and t-test (&alpha= 0.05. Results: This study findings revealed that using bleaching agent significantly decreased the  microhardness of composite resin in the bleaching groups compared to the control group, though the concentration of carbamide peroxide produced no significant effect on the microhardness value. (p>0.13 Conclusion: Bleaching therapy can cause a reduction in microhardness of Z250 composite and different concentrations of carbamide peroxide can reduce microhardness of Z250 to the same value.

  19. 7 CFR 250.56 - Provision of donated foods in NSLP.

    Science.gov (United States)

    2010-01-01

    ....56 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION DONATION OF FOODS FOR USE IN THE... Program (NSLP) and Other Child Nutrition Programs § 250.56 Provision of donated foods in NSLP....

  20. Socorro, NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  1. Clifton, AZ NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  2. 30 CFR 250.467 - How long must I keep records?

    Science.gov (United States)

    2010-07-01

    ... 250.467 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A... BOP tests Two years after the completion of drilling operations. (c) Completion of a well or of...

  3. El Paso, TX NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  4. Albuquerque, NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  5. 30 CFR 250.518 - What are the requirements for casing pressure management?

    Science.gov (United States)

    2010-07-01

    ... Operations Casing Pressure Management § 250.518 What are the requirements for casing pressure management? Once you install your wellhead, you must meet the casing pressure management requirements of API RP 90... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the requirements for casing...

  6. 30 CFR 250.294 - May I combine the Conceptual Plan and the DWOP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false May I combine the Conceptual Plan and the DWOP... Operations Plans (dwop) § 250.294 May I combine the Conceptual Plan and the DWOP? If your development project meets the following criteria, you may submit a combined Conceptual Plan/DWOP on or before the...

  7. Analysis of wind power ancillary services characteristics with German 250-MW wind data

    Energy Technology Data Exchange (ETDEWEB)

    Ernst, B.

    1999-12-09

    With the increasing availability of wind power worldwide, power fluctuations have become a concern for some utilities. Under electric industry restructuring in the US, the impact of these fluctuations will be evaluated by examining provisions and costs of ancillary services for wind power. This paper analyzes wind power in the context of ancillary services, using data from a German 250 Megawatt Wind project.

  8. Revamp of cable reel on 250 t converter ladle car%250 t转炉钢包车电缆卷筒改造

    Institute of Scientific and Technical Information of China (English)

    叶国英

    2014-01-01

    In view of the problems of burning the cable and the cable reel not running in No.3 Branch of General Steel-making Plant of WISCO,which led to the maintenance cost rising and affected the production,the drive way of cable reel and the cable sizing were optimized in 250 t converter ladle car.After that,the maintenance cost is de-creased deeply,and only 2 cables are needed by a ladle car every year,which ensure the normal production.%针对武钢炼钢总厂三分厂经常出现电缆烧损、电缆卷筒不转故障导致维修成本上升且影响生产的问题,对250 t转炉钢包车电缆卷筒的传动方式、电缆选型进行了改造。改造后,每台钢包车每年只需更换2根电缆,大大降低了维护成本,保证了生产的正常运行。

  9. A gas/liquid chromatographic-mass spectrometric method for the rapid screening of 250 pesticides in aqueous matrices

    Energy Technology Data Exchange (ETDEWEB)

    Chandramouli, B.; Harvan, D.; Brittain, S.; Hass, R. [Eno River Labs, LLC. Durham, NC (United States)

    2004-09-15

    Pesticide residues in food present a potentially serious and significant cause for concern. Many pesticides have been associated with significant health effects to the nervous and endocrine systems and some have been deemed carcinogenic. There are many well-established techniques for pesticide analysis. However, commercial pesticide methods have traditionally only been available for specific pesticide families, such as chlorinated pesticides or herbicides, and at detection limits ranging from 0.05 ppb to 1 ppm in aqueous matrices. Techniques that can quickly screen for the presence/absence of pesticide residues in food matrices are critical in ensuring the safety of food and water. This paper outlines a combined Gas Chromatographic-High Resolution Mass Spectrometric (GC-HRMS) and Liquid Chromatographic Tandem Mass Spectrometric (LC-MS/MS) screening assay for 250 pesticides that was developed for use in water, and soda samples at screening levels ranging from 0.1-5 ppb. The pesticides selected have been identified by the European Union as being of concern and the target of possible legislation. The list encompasses a variety of pesticide classes and compound groupings.

  10. Shielding data for 100-250 MeV proton accelerators double differential neutron distributions and attenuation in concrete

    CERN Document Server

    Agosteo, S; Mereghetti, A; Silari, M; Zajacova, Z

    2007-01-01

    Double differential distributions of neutrons produced by 100, 150, 200 and 250 MeV protons stopped in a thick iron target were simulated with the FLUKA Monte Carlo code at four emission angles: forward, 45°, transverse and 135° backwards. The attenuation in ordinary concrete of the dose equivalent due to secondary neutrons, protons, photons and electrons was calculated. Some of the resulting attenuation curves are best fitted by a double-exponential function rather than a single-exponential. The effect of various approximations introduced in the simulations is thoroughly discussed. The contribution to the total ambient dose equivalent from photons and protons is usually limited to a few percent, except in the backward direction where photons contribute more than 10% and up to 35% to the total dose for a shield thickness of 1 – 2 m. Source terms and attenuation lengths are given as a function of energy and emission angle, along with fit to the Monte Carlo data. An extensive comparison is made of values ob...

  11. Development of a quasi-monoenergetic neutron field using the 7Li(p,n)7Be reaction in the energy range from 250 to 390 MeV at RCNP.

    Science.gov (United States)

    Taniguchi, S; Nakao, N; Nakamura, T; Yashima, H; Iwamoto, Y; Satoh, D; Nakane, Y; Nakashima, H; Itoga, T; Tamii, A; Hatanaka, K

    2007-01-01

    A quasi-monoenergetic neutron field using the (7)Li(p,n)(7)Be reaction has been developed at the ring cyclotron facility at the Research Center for Nuclear Physics (RCNP), Osaka University. Neutrons were generated from a 10-mm-thick Li target injected by 250, 350 and 392 MeV protons and neutrons produced at 0 degrees were extracted into the time-of-flight (TOF) room of 100-m length through the concrete collimator of 10 x 12 cm aperture and 150 cm thickness. The neutron energy spectra were measured by a 12.7-cm diam x 12.7-cm long NE213 organic liquid scintillator using the TOF method. The peak neutron fluence was 1.94 x 10(10), 1.07 x 10(10) and 1.50 x 10(10) n sr(-1) per muC of 250, 350 and 392 MeV protons, respectively. The neutron spectra generated from various thick (stopping length) targets of carbon, aluminium, iron and lead, bombarded by 250 and 350 MeV protons, were also measured with the TOF method. Although these measurements were performed to obtain thick target neutron yields, they are also used as a continuous energy neutron field. These neutron fields are very useful for characterising neutron detectors, measuring neutron cross sections, testing irradiation effects for various materials and performing neutron shielding experiments.

  12. Debye relaxation and 250 K anomaly in glass forming monohydroxy alcohols

    CERN Document Server

    Bauer, S; Gainaru, C; Lunkenheimer, P; Hiller, W; Loidl, A; Böhmer, R

    2013-01-01

    A previous dielectric, near-infrared (NIR), and nuclear magnetic resonance study on the hydrogen-bonded liquid 2-ethyl-1-hexanol [C. Gainaru et al., Phys. Rev. Lett. 107, 118304 (2011)] revealed anomalous behavior in various static quantities near 250 K. To check whether corresponding observations can be made for other monohydroxy alcohols as well, these experimental methods were applied to such substances with 5, 6, 7, 8, and 10 carbon atoms in their molecular backbone. All studied liquids exhibit a change of behavior near 250 K which is tentatively ascribed to effects of hydrogen bond cooperativity. By analyzing the NIR band intensities, a linear cluster size is derived that agrees with estimates from dielectric spectroscopy. All studied alcohols, except 4-methyl-3-heptanol, display a dominant Debye-like peak. Furthermore, neat 2-ethyl-1-butanol exhibits a well resolved structural relaxation in its dielectric loss spectrum which so far has only been observed for diluted monohydroxy alcohols.

  13. A low-power 10-bit 250-KSPS cyclic ADC with offset and mismatch correction*

    Institute of Scientific and Technical Information of China (English)

    Zhao Hongliang; Zhao Yiqiang; Geng Junfeng; Li Peng; Zhang Zhisheng

    2011-01-01

    A low power 10-bit 250-k sample per second (KSPS) cyclic analog to digital converter (ADC) is presented. The ADC's offset errors are successfully cancelled out through the proper choice of a capacitor switching sequence. The improved redundant signed digit algorithm used in the ADC can tolerate high levels of the comparator's offset errors and switched capacitor mismatch errors. With this structure, it has the advantages of simple circuit configuration, small chip area and low power dissipation. The cyclic ADC manufactured with the Chartered 0.35 μm 2P4M process shows a 58.5 dB signal to noise and distortion ratio and a 9.4 bit effective number of bits at a 250 KSPS sample rate. It dissipates 0.72 mW with a 3.3 V power supply and occupies dimensions of 0.42 × 0.68 mm2.

  14. Proton-proton elastic scattering from 30 to 250 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Rusack, R.; Garbutt, D.; Siotis, I.; Gross, D.; Nitz, D.; Olsen, S.L.; Warren, G.; Abe, K.; Bomberowitz, R.; Goldhagen, P.; Sannes, F.; Tortora, J.

    1978-12-11

    We present measurements of the proton-proton elastic differential cross section for 1.0 < vertical-bartvertical-bar < 2.0 (GeV/c)/sup 2/ and incident proton momenta between 30 and 250 GeV/c. The minimum in the cross section near t approx. = - 1.5 (GeV/c)/sup 2/ develops monotonically with increasing incident proton momentum and the cross section remains nonzero up to our highest incident momentum of 250 GeV/c. The cross section at the second maximum near t approx. = - 1.8 (GeV/c)/sup 2/ falls with increasing incident momentum up to 210 GeV/c after which it starts to rise.

  15. Dispersive spherical optical model of neutron scattering from Al27 up to 250 MeV

    CERN Document Server

    Molina, A; Quesada, J M; Lozano, M

    2002-01-01

    A spherical optical model potential (OMP) containing a dispersive term is used to fit the available experimental database of angular distribution and total cross section data for n + Al27 covering the energy range 0.1- 250 MeV using relativistic kinematics and a relativistic extension of the Schroedinger equation. A dispersive OMP with parameters that show a smooth energy dependence and energy independent geometry are determined from fits to the entire data set. A very good overall agreement between experimental data and predictions is achieved up to 150 MeV. Inclusion of nonlocality effects in the absorptive volume potential allows to achieve an excellent agreement up to 250 MeV.

  16. Vernier Scan Results from the First RHIC Proton Run at 250 GeV

    CERN Document Server

    Drees, Angelika

    2010-01-01

    Using the Vernier scan or Van der Meer scan technique, where one beam is swept stepwise transversely across the other while measuring the collision rate as a function of beam displacement, the transverse beam profiles, the luminosity and the effective cross section of the detector in question can be measured. This report briefly recalls the vernier scan technique and presents results from the first RHIC polarized proton run at 250GeV per beam in 2009

  17. Development of Regional TSS Algorithm over Penang using Modis Terra (250 M) Surface Reflectance Product

    OpenAIRE

    Amin Abd Rahman Mat; Abdullah Khiruddin; Lim Hwee San; Embong Muhd Fauzi; Ahmad Fadhli; Yaacob Rosnan

    2016-01-01

    Total suspended sediment (TSS) plays a significant role in the environment. Many researchers show that TSS has a high correlation with the red portion of the visible light spectrum. The correlation is highly dependent on geography of the study area. The aim of this study was to develop specific algorithms utilizing corrected MODIS Terra 250-m surface reflectance (Rrs) product (MOD09) to map TSS over the Penang coastal area. Field measurements of TSS were performed during two cruise trips that...

  18. Electrically charged targets

    Science.gov (United States)

    Goodman, Ronald K.; Hunt, Angus L.

    1984-01-01

    Electrically chargeable laser targets and method for forming such charged targets in order to improve their guidance along a predetermined desired trajectory. This is accomplished by the incorporation of a small amount of an additive to the target material which will increase the electrical conductivity thereof, and thereby enhance the charge placed upon the target material for guidance thereof by electrostatic or magnetic steering mechanisms, without adversely affecting the target when illuminated by laser energy.

  19. The case for a generic phytosanitary irradiation dose of 250 Gy for Lepidoptera eggs and larvae

    Science.gov (United States)

    Hallman, Guy J.; Arthur, Valter; Blackburn, Carl M.; Parker, Andrew G.

    2013-08-01

    The literature on ionizing irradiation of Lepidoptera is critically examined for a dose that could serve as a generic phytosanitary treatment for all eggs and larvae of that order, which contains many quarantine pests that inhibit trade in fresh agricultural commodities. The measure of efficacy used in deriving this dose is the prevention of emergence of normal-looking adults that are assumed not able to fly. A dose of 250 Gy is supported by many studies comprising 34 species in 11 lepidopteran families, including those of significant quarantine importance. Two studies with two different species found that doses >250 Gy were necessary, but both of these are contradicted by other studies showing that 10,000 individuals) testing for families other than Tortricidae (the most important quarantine family in the Lepidoptera). Because several large-scale studies have been done with tortricids a dose of 250 Gy could be justifiable for Tortricidae if it is not acceptable for the entire Lepidoptera at this time.

  20. High efficiency carbon-based multilayers for LAMP at 250 eV

    Science.gov (United States)

    Wen, Mingwu; Huang, Qiushi; She, Rui; Jiang, Li; Zhang, Zhong; Wang, Zhanshan; Feng, Hua; Spiga, Daniele; Giglia, Angelo

    2015-09-01

    X-ray reflection near the Brewster's angle by multilayer mirrors can be used to detect the polarization from X-ray sources. The photon emission spectra from some isolated neutron stars and AGN/blazars etc. show that their emission is peaked at low energies near 250eV, which is just below carbon K-absorption edge. The Lightweight Asymmetry and Magnetism Probe (LAMP) is proposed as a micro-satellite mission dedicated for astronomical X-ray polarimetry working at 250 eV and is currently under early phase study. Co/C multilayers are selected and designed at the energy near 250eV with a grazing incident angle of 45°. The carbon layer thickness ratio is optimized to get the highest integral reflectivity which means larger effective signals in the astrophysics observation. The multilayer coatings were manufactured by direct current magnetron sputtering on D263 glasses and electroformed nickels and characterized using Grazing incidence X-ray reflectometry at 8keV. Reactive sputtering with 4%, 6% and 8% nitrogen were used to improve the Co/C multilayer interfaces respectively. Reflectivity for s-polarization and p-polarization light was measured at BEAR beamline in Elettra synchtron facility. Co/C multilayer deposited with 6% nitrogen exhibits the best performance comparing to other multilayers with different nitrogen content.

  1. Characterization of aging-induced microstructural changes in M250 maraging steel using magnetic parameters

    Energy Technology Data Exchange (ETDEWEB)

    Rajkumar, K.V. [Metallurgy and Materials Group, Indira Gandhi Centre for Atomic Research, Kalpakkam 603102 (India); Vaidyanathan, S. [Metallurgy and Materials Group, Indira Gandhi Centre for Atomic Research, Kalpakkam 603102 (India); Kumar, Anish [Metallurgy and Materials Group, Indira Gandhi Centre for Atomic Research, Kalpakkam 603102 (India); Jayakumar, T. [Metallurgy and Materials Group, Indira Gandhi Centre for Atomic Research, Kalpakkam 603102 (India)]. E-mail: tjk@igcar.gov.in; Raj, Baldev [Metallurgy and Materials Group, Indira Gandhi Centre for Atomic Research, Kalpakkam 603102 (India); Ray, K.K. [Indian Institute of Technology, Kharagpur 721302 (India)

    2007-05-15

    The best combinations of mechanical properties (yield stress and fracture toughness) of M250 maraging steel is obtained through short-term thermal aging (3-10 h) at 755 K. This is attributed to the microstructure containing precipitation of intermetallic phases in austenite-free low-carbon martensite matrix. Over-aged microstructure, containing reverted austenite degrades the mechanical properties drastically. Hence, it necessitates identification of a suitable non-destructive evaluation (NDE) technique for detecting any reverted austenite unambiguously during aging. The influence of aging on microstructure, room temperature hardness and non-destructive magnetic parameters such as coercivity (H {sub c}), saturation magnetization (M {sub s}) and magnetic Barkhausen emission (MBE) RMS peak voltage is studied in order to derive correlations between these parameters in aged M250 maraging steel. Hardness was found to increase with precipitation of intermetallics during initial aging and decrease at longer durations due to austenite reversion. Among the different magnetic parameters studied, MBE RMS peak voltage was found to be very sensitive to austenite reversion (non-magnetic phase) as they decreased drastically up on initiation of austenite reversion. Hence, this parameter can be effectively utilized to detect and quantify the reverted austenite in maraging steel specimen. The present study clearly indicates that the combination of MBE RMS peak voltage and hardness can be used for unambiguous characterization of microstructural features of technological and practical importance (3-10 h of aging duration at 755 K) in M250 grade maraging steel.

  2. 30 CFR 250.217 - What solid and liquid wastes and discharges information and cooling water intake information must...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What solid and liquid wastes and discharges information and cooling water intake information must accompany the EP? 250.217 Section 250.217 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF...

  3. 30 CFR 250.248 - What solid and liquid wastes and discharges information and cooling water intake information must...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What solid and liquid wastes and discharges information and cooling water intake information must accompany the DPP or DOCD? 250.248 Section 250.248 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL...

  4. Geluidimmissie van Thalys en Ansaldo V250 treinen op het HSL spoor bij twee woningen in Kaag en Braassem

    NARCIS (Netherlands)

    Hof, J. van 't; Staats, F.; Graafland, F.; Prevo, R.

    2014-01-01

    TNO heeft in opdracht van ProRail de geluidimmissieniveaus gemeten van de Ansaldo V250 en de Thalys hogesnelheidstreinen die op het spoor van de HSL-Zuid met hoge snelheid rijden, bij twee woningen in de gemeente Kaag en Braassem. Tijdens dit onderzoek rijden er treinen van het type Ansaldo V250, Th

  5. 30 CFR 250.524 - When am I required to take action from my casing diagnostic test?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When am I required to take action from my casing diagnostic test? 250.524 Section 250.524 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil...

  6. 30 CFR 250.523 - How long do I keep records of casing pressure and diagnostic tests?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How long do I keep records of casing pressure and diagnostic tests? 250.523 Section 250.523 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil...

  7. 75 FR 62919 - Notice of Final Federal Agency Actions on the Route 250 Bypass Interchange at McIntire Road...

    Science.gov (United States)

    2010-10-13

    ... of Route 250 Bypass and McIntire Road. The project would reduce traffic congestion and improve... at McIntire Road Project in Virginia AGENCY: Federal Highway Administration (FHWA), DOT. ACTION... the Route 250 Bypass Interchange at McIntire Road project in the City of Charlottesville,...

  8. 30 CFR 250.1164 - What are the requirements for flaring or venting gas containing H2S?

    Science.gov (United States)

    2010-07-01

    ... venting gas containing H2S? 250.1164 Section 250.1164 Mineral Resources MINERALS MANAGEMENT SERVICE... requirements for flaring or venting gas containing H2S? (a) You may not vent gas containing H2S, except for... average atmosphere concentration of H2S of 20 ppm or higher anywhere on the platform. (b) You may...

  9. 12 CFR 250.412 - Interlocking relationships between member bank and insurance company-mutual fund complex.

    Science.gov (United States)

    2010-01-01

    ... mutual fund shares and life insurance policies that would provide increased competitive strength in a... Fund, Inc. (“Fund”), the mutual fund, was closely related to X Life Insurance Company (“Insurance... and insurance company-mutual fund complex. 250.412 Section 250.412 Banks and Banking FEDERAL...

  10. 21 CFR 250.12 - Stramonium preparations labeled with directions for use in self-medication regarded as misbranded.

    Science.gov (United States)

    2010-04-01

    ... for use in self-medication regarded as misbranded. 250.12 Section 250.12 Food and Drugs FOOD AND DRUG... for use in self-medication regarded as misbranded. (a) Stramonium products for inhalation have been... ingredients, will be regarded as misbranded if they are labeled with directions for use in self-medication....

  11. 21 CFR 250.11 - Thyroid-containing drug preparations intended for treatment of obesity in humans.

    Science.gov (United States)

    2010-04-01

    ... nervous system stimulants, with or without one or more additional drug substances such as barbiturates or.... (b) Combinations of thyroid or other thyrogenic drugs with central nervous system stimulants with or... treatment of obesity in humans. 250.11 Section 250.11 Food and Drugs FOOD AND DRUG...

  12. p250GAP is a novel player in the Cdh1-APC/Smurf1 pathway of axon growth regulation.

    Directory of Open Access Journals (Sweden)

    Madhuvanthi Kannan

    Full Text Available Axon growth is an essential process during brain development. The E3 ubiquitin ligase Cdh1-APC has emerged as a critical regulator of intrinsic axon growth control. Here, we identified the RhoGAP p250GAP as a novel interactor of the E3 ubiquitin ligase Cdh1-APC and found that p250GAP promotes axon growth downstream of Cdh1-APC. We also report that p250GAP undergoes non-proteolytic ubiquitination and associates with the Cdh1 substrate Smurf1 to synergistically regulate axon growth. Finally, we found that in vivo knockdown of p250GAP in the developing cerebellar cortex results in impaired migration and axonal growth. Taken together, our data indicate that Cdh1-APC together with the RhoA regulators p250GAP and Smurf1 controls axon growth in the mammalian brain.

  13. Fast ignitor target studies for HiPER

    Energy Technology Data Exchange (ETDEWEB)

    Atzeni, S; Bellei, C; Schiavi, A [Dipartimento di Energetica, Universita di Roma ' La Sapienza' and CNISM (Italy); Davies, J R; Silva, L; Sorasio, G [Instituto Superior Tecnico, Lisbon (Portugal); Evans, R G [The Blackett Laboratory, Imperial College, Prince Consort Road, London (United Kingdom); Honrubia, J J [GIFI, Universidad Politecnica, Madrid (Spain); Nicolai, P; Ribeyre, X; Schurtz, G; Olazabal, M [CELIA, Universite Bordeaux 1, Talence (France); Badziak, J [IPPLM, Euratom Association, Warsaw (Poland); Meyer-ter-Vehn, J [Max-Planck-Institut fuer Quantenoptik, Garching (Germany)], E-mail: javier.honrubia@upm.es

    2008-05-15

    The HiPER facility has been proposed recently to demonstrate fast ignition of laser driven inertial fusion targets. According to the present design, HiPER will have a 3{omega}, multi-beam, multi-ns-pulse of about 250 kJ and a 2{omega} or 3{omega} ignition beam delivering 70 kJ in about 15 ps. We present here studies on laser-driven fast-ignitor targets driven by 100-300 kJ compression pulses, followed by 70-100 kJ ignition pulses.

  14. Paired observation of californium-252 neutron intraluminal brachytherapy combined with external-beam radiotherapy with and without lead shielding for cervical cancer%252 Cf中子腔内照射结合挡铅与不挡铅外照射治疗宫颈癌的配对观察

    Institute of Scientific and Technical Information of China (English)

    戴卓捷; 雷新; 陈永红; 刘佳

    2015-01-01

    目的:比较252 Cf中子腔内照射结合挡铅盆腔对穿野和不挡铅箱式四野外照射治疗宫颈癌的治疗结果。方法2004—2007年本院收治的Ⅱa—Ⅲb 期的宫颈鳞癌患者,按照临床分期、年龄、肿瘤大小、贫血程度为配对条件,共筛选出26对(52例)研究对象,分为挡铅盆腔对穿野组(挡铅组)和不挡铅箱式四野组(不挡铅组)。两组患者外照射期间穿插252 Cf中子后装治疗。 Kaplan?Meier法计算5年LC、OS、DFS 并 Logrank 检验差异,晚期并发症发生率差异行 McNemar 法检验。结果挡铅、不挡铅组5年LC 率分别为85%、81%(P=0??014),OS 率分别为89%、73%(P=0??013),DFS 率分别为89%、73%(P=0??013),晚期并发症发生率分别为12%、23%(P=0??008)。结论腔内照射结合外照射治疗宫颈癌时无论采取对穿野还是箱式四野,后程前后野中央均应挡铅。%Objective To compare the efficacy between californium?252 ( 252 Cf ) neutron intraluminal brachytherapy combined with external?beam radiotherapy with lead?shielding pelvic parallel opposing field technique and non?lead?shielding four?field box technique for cervical cancer. Methods A total of 52 patients with stage Ⅱa?Ⅲb cervical squamous cell carcinoma who were admitted to our hospital from 2004 to 2007 were enrolled as subjects and paired by clinical stage, age, tumor size, and degree of anemia. The 26 pairs of patients were divided into lead?shielding pelvic parallel opposing field group (lead?shielding group) and non?lead?shielding four?field box group (non?lead?shielding group). For all patients in both groups, 252 Cf neutron brachytherapy was added in external?beam radiotherapy. The local control (LC), overall survival (OS), and disease?free survival (DFS) rates were calculated using the Kaplan?Meier method and analyzed using the log?rank test. The difference in the incidence of late complications was

  15. Context homogeneity facilitates both distractor inhibition and target enhancement.

    Science.gov (United States)

    Feldmann-Wüstefeld, Tobias; Schubö, Anna

    2013-05-06

    Homogeneous contexts were shown to result in prioritized processing of embedded targets compared to heterogeneous contexts (Duncan & Humphreys, 1989). The present experiment used behavioral and ERP measures to examine whether context homogeneity affects both enhancing relevant information and inhibiting irrelevant in contexts of varying homogeneity. Targets and distractors were presented laterally or on the vertical midline which allowed disentangling target- and distractor-related activity in the lateralized ERP (Hickey, diLollo, & McDonald, 2009). In homogeneous contexts, targets elicited an NT component from 150 ms on and a PD component from 200 ms on, showing early attention deployment at target locations and active suppression of distractors. In heterogeneous contexts, an NT component was also found from 150 ms on and PD was found from 250 ms on, suggesting delayed suppression of the distractor. Before 250 ms, distractors in heterogeneous contexts elicited a contralateral negativity, indicating attentional capture of the distractor prior to active suppression. In sum the present results suggest that top-down control of attention is more pronounced in homogeneous than in heterogeneous contexts.

  16. An Analysis of 250 MDMA Addicts%250例苯丙胺类摇头丸(MDMA)滥用人群分析

    Institute of Scientific and Technical Information of China (English)

    孙毅; 徐本树; 王志强; 金俊; 吕秋霖; 张惠民

    2004-01-01

    目的:了解苯丙胺类物质摇头丸(MDMA)滥用人群人口学特征及其MDMA的精神活性作用.方法:制定统一问卷,对2001年1月-2002年11月在我院住院MDMA滥用者逐一进行登记.结果:总共调查250例摇头丸(MDMA)滥用者.250例MDMA滥用者平均年龄27.25±7.46 a.未婚青年女性141例,占总例数56.6%.文化程度较高,高中以上文化程度165例,占总例数66.04%.滥用方式大多数以啤酒送服,其次是矿泉水、饮料.滥用场所以歌厅和迪厅为主.每周使用2次以上者97例,占38.68%.MDMA的起效时间为25.61±11.06 min,作用持续时间为3.44±1.68 h.滥用后主观感受及行为表现依次为出汗、头晕、口干、心情愉快等.MDMA作用消失后部分滥用者表现为失眠、食欲下降、记忆力减退、厌食、疲乏、睡眠增多、食欲增大等.结论:近年来MDMA滥用者有增多趋势,部分滥用者有向强制性用药的模式趋势发展,应引起人们足够重视.

  17. Improved design of a certaintype GO-Kart of 250 ml discharge%250 ml排量卡丁车的改进设计

    Institute of Scientific and Technical Information of China (English)

    徐振宇; 陈益帅

    2011-01-01

    为解决目前最受市场欢迎的250 ml排量系列卡丁车"减振性能差、在崎岖路面高速行驶稳定性不佳"的问题,将高档轿车上用的双摆臂前轮悬架设计技术整合到这一排量的卡丁车中去,同时改变以往后轮单纯依靠橡胶轮胎减振的情况,后悬架采用整体桥式结构重新设计.在改进设计中开展了卡丁车前、后悬架减振器速度特性试验、等效刚度试验、悬架总体侧倾角刚度试验,提出了将计算机三维设计与试制、试验相结合的改进设计方法.对改进设计前后的减振器阻尼、悬架等效刚度及悬架总体侧倾刚度值的变化进行了评价,并完成了整车试制后的路面测试.试验结果表明,改进后的卡丁车大大提高了崎岖路面行驶的稳定性和平顺性.%In order to solve the problems of poor stability on rugged roads during high - speed driving, as well as poor damping performance of the most popular Kart ( displacement: 250 ml), the following areas were investigated: the double-arm front wheel suspension design of luxury sedans was integrated into the Kart. The past situation of relying solely on the rear wheel damping was changed. And the rear suspension was redesigned with the overall bridge structure. After the tests of the front and rear suspension damper rate, the equivalent stiffness, and the overall roll angle suspension stiffness, the method of combining computer three-dimensional design, trial-manufacture and tests was presented. The absorber's damping, suspension equivalent stiffness and overall roll angle suspension stiffness before and after design improvement were evaluated, and the finished trial - manufactured Kart was tested on the road. The experimental results show that the stability and smoothness of the Kart had been greatly enhanced when it is on rough roads.

  18. Targeted Cancer Therapies

    Science.gov (United States)

    ... targeted therapies are directed against HER-2, including trastuzumab (Herceptin®), which is approved to treat certain breast and ... traditional chemotherapy drugs. For example, the targeted therapy trastuzumab (Herceptin®) has been used in combination with docetaxel , ...

  19. High Power Cryogenic Targets

    Energy Technology Data Exchange (ETDEWEB)

    Gregory Smith

    2011-08-01

    The development of high power cryogenic targets for use in parity violating electron scattering has been a crucial ingredient in the success of those experiments. As we chase the precision frontier, the demands and requirements for these targets have grown accordingly. We discuss the state of the art, and describe recent developments and strategies in the design of the next generation of these targets.

  20. A Dependence Study of $\\Xi^{*0}$ and $\\bar{\\Xi}^{*0}$ in 250 GeV/c $\\pi^-$. $K^-$ -nucleon Interactions

    Energy Technology Data Exchange (ETDEWEB)

    Seixas de Rezende, Fabio Antonio; /Rio de Janeiro, CBPF

    2005-04-01

    A direct measurement of the mass number (A) dependence of the production of the hyperon {Xi}*{sup 0} and its opposite {bar {Xi}}*{sup 0} in {pi}{sup -}, K{sup -} beam-nucleon interactions at 250 GeV/c is reported. The data derive from the experiment E769 at Fermilab. The results were obtained for different targets: Be, Al, Cu and W. It was observed the data are found to be well described by the parametrization {sigma}{sub A} = {sigma}{sub 0}A{sup {alpha}}, {alpha} being calculated for different beams. The results obtained are compared with those results of E769 experiment. The results shown here are preliminary.

  1. Shielding data for 100 250 MeV proton accelerators: Attenuation of secondary radiation in thick iron and concrete/iron shields

    Science.gov (United States)

    Agosteo, S.; Magistris, M.; Mereghetti, A.; Silari, M.; Zajacova, Z.

    2008-08-01

    Double differential distributions of neutrons produced by 100, 150, 200 and 250 MeV protons stopped in a thick iron target were calculated with the FLUKA Monte Carlo code at four emission angles: forward, 45°, transverse and 135° backwards. The attenuation in thick iron shields of the dose equivalent due to neutrons, protons, photons and electrons was also calculated. The contribution to the total ambient dose equivalent from photons and protons is limited to a few percent at maximum. Source terms and attenuation lengths are given as a function of energy and emission angle, along with fits to the Monte Carlo data, for shallow depth and deep penetration in the shield. A brief discussion of simulations performed with composite iron/concrete shields is also given, showing the need for further investigations.

  2. Transverse momentum compensation in [pi][sup +]p interactions at 250 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Agababyan, N.M.; Ajinenko, I.V.; Bialkowska, H.; Chliapnikov, P.V.; Botterweck, F.; Charlet, M.; Wolf, E.A. de; Dziunikowska, K.; Endler, A.M.F.; Garutchava, Z.C.; Gulkanyan, H.R.; Kisielewska, D.; Kittel, W.; Olkiewicz, K.; Rizatdinova, F.K.; Shabalina, E.K.; Smirnova, L.N.; Stepaniak, J.; Tikhonova, L.A.; Tomaradze, A.G.; Wroblewski, A.; Verbeure, F.; Zotkin, S.A. (Dept. of Physics, Univ. Instelling Antwerpen, Wilrijk (Belgium) Inter-Univ. Inst. for High Energies, Brussels (Belgium) Inst. of Physics and Nuclear Techniques of Academy of Mining and Metallurgy and Inst. of Nuclear Physics, Krakow (Poland) Nuclear Physics Inst., Moscow State Univ. (Russian Federation) Univ. of Nijmegen/NIKHEF (Netherlands) Inst. for High Energy Physics, Protvino (Russian Federation) Centro Brasileiro de Pesquisas Fisicas, Rio de Janeiro, RJ (Brazil) Inst. of High Energy Physics of Tbilisi State Univ. (Georgia) Univ. of Warsaw and Inst. for Nuclear Studies, Warsaw (Poland) Inst. of Physics, Yerevan (Arme; EHS/NA22 Collaboration

    1994-11-01

    Compensation of transverse momentum is studied in [pi][sup +] p interactions at 250 GeV/c. Significant p[sub T]-transfer is found between c.m.s. hemispheres. With respect to the beam axis transverse momentum is compensated over the whole event, with respect to the sphericity axis mainly within one hemisphere. The highest p[sub T] in the event is mainly compensated by increased multiplicity. The QGSM and FRITIOF models qualitatively reproduce these effects, but important differences are observed. (orig.)

  3. Off-resonance transformer charging for 250-kV water Blumlein

    Energy Technology Data Exchange (ETDEWEB)

    Cook, E.; Reginato, L.

    1978-06-15

    An off-resonance transformer for charging a 250-kV Blumlein system provides a viable alternative to other charging schemes by permitting the use of conventional thyratrons. Such a transformer must have reliability, a reasonable voltage step-up, and a non-reversing primary current. The analysis, design, and performance data for such a transformer are presented. The strong interrelationship between transformer design and Blumlein requirements necessitates that Blumlein description and design criterion be briefly presented prior to transformer design such that transformer load requirements be defined.

  4. Pulse radiolysis studies of liquid heavy water at temperatures up to 250 degrees C

    Energy Technology Data Exchange (ETDEWEB)

    Stuart, C.R.; Ouellette, D.C.; Elliot, A.J

    2002-09-01

    This report documents the rate constants and associated activation energies for the reactions of the primary radical species, e{sub aq}{sup -}, {center_dot}OD and {center_dot}D, which are formed during the radiolysis of heavy water within the temperature range 20 to 250 {sup o}C. These heavy-water data have been compared with the corresponding information for light water. These kinetic data form part of the database that is required to model the aqueous radiation chemistry that occurs within the core of the heavy water cooled and moderated CANDU reactor. (author)

  5. Ultrasonic Characterization of Aging Behavior in M250 Grade Maraging Steel

    Science.gov (United States)

    Yeheskel, Ori

    2009-03-01

    The increase in sound velocities during the aging of M250 maraging steel reported by Rajkumar et al. was analyzed. The present article provides a new perspective on why and to what extent the sound velocities change during aging. The main parameter that affects the elastic moduli and the sound velocities in the early and intermediate stages of aging in maraging steel is the depletion of Ni from the martensitic matrix due to Ni3Ti and Ni3Mo formation. The issue of sound velocity increase with aging time was addressed here in a few different ways to support the validity of Ni depletion.

  6. Alkaline electrolysis cell at high temperature and pressure of 250 °C and 42 bar

    DEFF Research Database (Denmark)

    Allebrod, Frank; Chatzichristodoulou, Christodoulos; Mogensen, Mogens Bjerg

    2013-01-01

    A new type of alkaline electrolysis cells with nickel foam based gas diffusion electrodes and KOH (aq) immobilized in mesoporous SrTiO3 has been developed and tested at temperatures and pressures up to 250 °C and 42 bar, respectively. Current densities of 1.0 A cm−2 have been measured at a cell...... voltage of 1.5 V without the use of expensive noble metal catalysts. High electrical efficiency and current density combined with relatively small production costs may lead to both reduced investment and operating costs for hydrogen and oxygen production....

  7. Study of intranuclear collision effects in interactions of K sup + /. pi. sup + mesons with Al and Au nuclei at 250 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Agababyan, N.M.; Gulkanyan, G.; Hakobyan, R.Sh.; Karamyan, J.K.; Megrabyan, S.S. (Erevan Inst. of Physics (Armenia)); Ajinenko, I.V.; Chliapnikov, P.V. (Institut Fiziki Vysokikh Ehnergij, Serpukhov (Russia)); Botterweck, F.; Charlet, M.; Kittel, W. (Katholieke Univ. Nijmegen (Netherlands) NIKHEF-H, Nijmegen (Netherlands)); Wolf, E.A. de; Verbeure, F. (Universitaire Instelling Antwerpen, Wilrijk (Belgium). Dept. of Physics Interuniversity Inst. for High Energies, Brussels (Belgium)); Dziunikowska, K.; Kisielewska, D.; Olkiewicz, K. (Institute of Physics and Nuclear Techniques, Cracow (Poland) Institute of Nuclear Physics, Cracow (Poland)); Endler, A.M. (Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro (Brazil)); Levchenko, B.B.; Rizatdinova, F.; Shabalina, L. (Moscow State Univ. (Russia)); Wischnewski, R. (Institut fuer Hochenergiephysik, Berlin-Zeuthen (Germany)); EHS-NA22 Collaboration

    1992-11-01

    Multiplicity, inclusive, correlation and collective characteristic of multiparticle production processes in K{sup +} Al, K{sup +} Au, {pi}{sup +} Al and {pi}{sup +} Au interactions at 250 GeV/c are studied with the European Hybrid Spectrometer, providing high statistics and almost 4{pi} acceptance for final state charged particles. It is shown that the proton energy spectrum practically does not depend on the target atomic weight, but the proton angular distributions reveal a strong A-dependence. In a model independent way, the average number of intranuclear collisions is extracted, and it is shown that their dominant part (60% for Al and 80% for Au) is caused by interactions of the non-leading particles produced in the target fragmentation. The multiplication ratio of the produced particles for the Au nucleus changes from R{approx equal}40 at the smallest rapidities in the target framentation region, down to R=0.37{+-}0.06 at the largest rapidities in the beam fragmentation region. It is found that the average total longitudinal momentum of the charged products of the beam fragmentation depends weakly on the number of leading hadron (cluster) intranuclear collisions which are characterized by a low inelasticity coefficient =0.17{+-}0.03. (orig.).

  8. Benchmark calculations on residue production within the EURISOL DS project; Part I: thin targets

    CERN Document Server

    David, J.C; Boudard, A; Doré, D; Leray, S; Rapp, B; Ridikas, D; Thiollière, N

    Report on benchmark calculations on residue production in thin targets. Calculations were performed using MCNPX 2.5.0 coupled to a selection of reaction models. The results were compared to nuclide production cross-sections measured in GSI in inverse kinematics

  9. Benchmark calculations on residue production within the EURISOL DS project; Part II: thick targets

    CERN Document Server

    David, J.-C; Boudard, A; Doré, D; Leray, S; Rapp, B; Ridikas, D; Thiollière, N

    Benchmark calculations on residue production using MCNPX 2.5.0. Calculations were compared to mass-distribution data for 5 different elements measured at ISOLDE, and to specific activities of 28 radionuclides in different places along the thick target measured in Dubna.

  10. Development of distributed target

    CERN Document Server

    Yu Hai Jun; Li Qin; Zhou Fu Xin; Shi Jin Shui; Ma Bing; Chen Nan; Jing Xiao Bing

    2002-01-01

    Linear introduction accelerator is expected to generate small diameter X-ray spots with high intensity. The interaction of the electron beam with plasmas generated at the X-ray converter will make the spot on target increase with time and debase the X-ray dose and the imaging resolving power. A distributed target is developed which has about 24 pieces of thin 0.05 mm tantalum films distributed over 1 cm. due to the structure adoption, the distributed target material over a large volume decreases the energy deposition per unit volume and hence reduces the temperature of target surface, then reduces the initial plasma formalizing and its expansion velocity. The comparison and analysis with two kinds of target structures are presented using numerical calculation and experiments, the results show the X-ray dose and normalized angle distribution of the two is basically the same, while the surface of the distributed target is not destroyed like the previous block target

  11. Targeted cancer therapies

    Institute of Scientific and Technical Information of China (English)

    Li Yan; Neal Rosen; Carlos Arteaga

    2011-01-01

    With unprecedented understanding of molecular events underlying human cancer in this genomic era, a large number of drugs specifically targeting hypothesized oncogenic drivers to which tumors are potentially addicted to have been developed and continue to be developed. These targeted cancer therapies are being actively tested in clinical trials with mixed successes. This editorial provides an overview on successful targeted cancer drugs on the market and those drugs that are in late clinical development stages. Importantly, the article lays out main challenges in developing molecular targeted therapies and potential path forward to overcome these challenges, as well as opportunities for China in this new era of targeted agents. The editorial serves as an introduction to the Targeted Cancer Therapies serias that will review in depth of major pathways and drugs targeting these pathways to be published in the coming issues of the Chinese Journal of Cancer.

  12. Clinicopathological analysis of 250 patients with early-stage gastric cancer%250例早期胃癌临床病理分析

    Institute of Scientific and Technical Information of China (English)

    钱建忠; 赵可; 李世兰; 徐洪明

    2010-01-01

    Objective To explore the factors associated with early diagnosis of gastric cancer.Methods Clinical data were retrospectively analyzed for 250 patients with early-stage gastric cancer (EGG) from 2005 to 2008, during which the concept of intra-epithelial neoplasia(IN) was adopted in our department. Results On preoperative endoscopic biopsy with pathological exam, there were 15 cases suspicious for cancer, 90 with high-grade IN(HGIN), and 15 gastric cancer. Postoperative pathological exam of the surgical specimen showed infiltrating early-stage cancer in 224 patients, of which 5(2.2%) were type Ⅰ(all were Tsm), 190 (84.8%) were type Ⅱ including Tm in 82 and Tsm in 108 patients, 29 were type Ⅲ (5 Tm and 24 Tsm). Twenty-six patients had non-infiltrating lesions(Tis).There were 184(73.6%)well-differentiated tumors, including 26 Tis, 58 Tm, and 100 Tsm. Lymphatic metastasis was identified in 21 patients, of which 2(2.3%) were Tin(all were poorly-differentiated) and 19 (13.9%) were Tsm. Lymphadenopathy was present in 15(7.9%) cases in type Ⅱ, and in 6(20.7%) in type Ⅲ. of the 90 cases with a preoperative diagnosis of HGIN, 24 were found to be Tis, 29 were Tin, and 37 were Tsm on postoperative pathological assessment. Conclusions Well-differentiation is the main histological type in EGC. The adoption of the concept of IN is associated with improved detection of EGC, which warrants further investigation.%目的 探讨进一步提高早期胃癌诊断水平的因素.方法 对2005-2008年间应用上皮内瘤变(IN)的概念诊断的250例早期胃癌患者的病理资料进行分析.结果 本组患者术前内镜活检诊断可疑癌15例,高级别上皮内瘤变(HGIN)90例,胃癌145例.术后病理诊断浸润型早期胃癌224例,其中Ⅰ型5例(2.2%),均为黏膜下癌(Tsm)患者;Ⅱ型190例(84.8%),有82例为黏膜内癌(Tm),108例为Tsm;Ⅲ型29例,5例Tm,24例Tsm.未浸润性病变(Tis)26例.以高分化为主要组织学类型者184例(73.6%),其中26

  13. Molecular gas kinematics within the central 250 pc of the Milky Way

    CERN Document Server

    Henshaw, J D; Kruijssen, J M D; Davies, B; Bally, J; Barnes, A; Battersby, C; Burton, M; Cunningham, M R; Dale, J E; Ginsburg, A; Immer, K; Jones, P A; Kendrew, S; Mills, E A C; Molinari, S; Moore, T J T; Ott, J; Pillai, T; Rathborne, J; Schilke, P; Schmiedeke, A; Testi, L; Walker, D; Walsh, A; Zhang, Q

    2016-01-01

    Using spectral-line observations of HNCO, N2H+, and HNC, we investigate the kinematics of dense gas in the central ~250 pc of the Galaxy. We present SCOUSE (Semi-automated multi-COmponent Universal Spectral-line fitting Engine), a line fitting algorithm designed to analyse large volumes of spectral-line data efficiently and systematically. Unlike techniques which do not account for complex line profiles, SCOUSE accurately describes the {l, b, v_LSR} distribution of CMZ gas, which is asymmetric about Sgr A* in both position and velocity. Velocity dispersions range from 2.6 km/s28. The gas is distributed throughout several "streams", with projected lengths ~100-250 pc. We link the streams to individual clouds and sub-regions, including Sgr C, the 20 and 50 km/s clouds, the dust ridge, and Sgr B2. Shell-like emission features can be explained by the projection of independent molecular clouds in Sgr C and the newly identified conical profile of Sgr B2 in {l ,b, v_LSR} space. These features have previously invoked...

  14. Properties of compact 250 \\mu m emission and HII regions in M33 (HERM33ES)

    CERN Document Server

    Verley, S; Kramer, C; Xilouris, E M; Boquien, M; Calzetti, D; Combes, F; Buchbender, C; Braine, J; Quintana-Lacaci, G; Tabatabaei, F S; Lord, S; Israel, F; Stacey, G; van der Werf, P

    2010-01-01

    Within the framework of the HERM33ES Key Project, using the high resolution and sensitivity of the Herschel photometric data, we study the compact emission in the Local Group spiral galaxy M33 to investigate the nature of the compact SPIRE emission sources. We extracted a catalogue of sources at 250um in order to investigate the nature of this compact emission. Taking advantage of the unprecedented Herschel resolution at these wavelengths, we also focus on a more precise study of some striking Halpha shells in the northern part of the galaxy. We present a catalogue of 159 compact emission sources in M33 identified by SExtractor in the 250um SPIRE band that is the one that provides the best spatial resolution. We also measured fluxes at 24um and Halpha for those 159 extracted sources. The morphological study of the shells also benefits from a multiwavelength approach including Halpha, far-UV from GALEX, and infrared from both Spitzer IRAC 8um and MIPS 24um in order to make comparisons. For the 159 compact sour...

  15. Square lattice honeycomb tri-carbide fuels for 50 to 250 KN variable thrust NTP design

    Science.gov (United States)

    Anghaie, Samim; Knight, Travis; Gouw, Reza; Furman, Eric

    2001-02-01

    Ultrahigh temperature solid solution of tri-carbide fuels are used to design an ultracompact nuclear thermal rocket generating 950 seconds of specific impulse with scalable thrust level in range of 50 to 250 kilo Newtons. Solid solutions of tri-carbide nuclear fuels such as uranium-zirconium-niobium carbide. UZrNbC, are processed to contain certain mixing ratio between uranium carbide and two stabilizing carbides. Zirconium or niobium in the tri-carbide could be replaced by tantalum or hafnium to provide higher chemical stability in hot hydrogen environment or to provide different nuclear design characteristics. Recent studies have demonstrated the chemical compatibility of tri-carbide fuels with hydrogen propellant for a few to tens of hours of operation at temperatures ranging from 2800 K to 3300 K, respectively. Fuel elements are fabricated from thin tri-carbide wafers that are grooved and locked into a square-lattice honeycomb (SLHC) shape. The hockey puck shaped SLHC fuel elements are stacked up in a grooved graphite tube to form a SLHC fuel assembly. A total of 18 fuel assemblies are arranged circumferentially to form two concentric rings of fuel assemblies with zirconium hydride filling the space between assemblies. For 50 to 250 kilo Newtons thrust operations, the reactor diameter and length including reflectors are 57 cm and 60 cm, respectively. Results of the nuclear design and thermal fluid analyses of the SLHC nuclear thermal propulsion system are presented. .

  16. Temperature variation and its driving forces over the Antarctic coastal regions in the past 250 years

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    By comparing the oxygen isotopic temperatures recorded by many shallow ice cores fromthe coastal regions of Antarctica, this paper presents the special characteristics of the temperaturevariations over the Antarctic coastal regions in the past 50 years, 150 years and 250 years. In thepast 50 years, the isotopic temperatures recorded in the ice cores over different sites on the Antarcticcoastal regions differ greatly. For instance, although increasing isotopic temperatures have beenreported for many sites studied, many sites show decreasing trends, the regional regularity intemperature variations is still insignificant. In the past 150 years, the isotopic temperature trends inthe coastal regions of Antarctica show an alternate-distributing pattern. In the past 250 years, all theice cores from the coastal regions of Antarctica have recorded the so-called Little Ice Age (LIA). Theabove-mentioned spatial characteristics of the temperature variations over the Antarctic coastalregions are likely to reflect the impacts of the unique Southern Hemisphere atmospheric circulation,the Antarctic Circumpolar Wave (ACW) and the special terrain (such as the large drainage basins) onthe coastal regions of Antarctica. Furthermore, the impacting intensity of the unique SouthernHemisphere atmospheric circulation, the Antarctic Circumpolar Wave and the special terrain differs interms of the temporal scale of the temperature change.

  17. Microstructure and Hardness of T250 Maraging Steel in Heat Affected Zone

    Institute of Scientific and Technical Information of China (English)

    MO De-feng; HU Zheng-fei; CHEN Shu-juan; WANG Chun-xu; HE Guo-qiu

    2009-01-01

    Electron-beam (EB) welding was used in T250 maraging steel,microstructures of both base material and heat affected zone (HAZ) were investigated by optical microscopy (OM),scanning electron microscopy (SEM) and transmission electron microscopy (TEM),and microhardness was tested.The results showed that during EB welding,the HAZ of T250 maraging steel exhibited a continuous gradient structure.The microstructure of the entire HAZ,from fusion line,could be divided into four zones:fusion zone,overheated zone,transition zone,and hardened zone.The microhardness showed a distinct regularity in each area.The softest region was the fusion zone,whereas the hardest was the hardened zone.In the overheated zone,the hardness increased as the grain size decreased.Furthermore,in the transition zone,the hardness level dropped noticeably.The peak temperature during the thermal cycle had a great influence on the formation of reverted austenite and dissolution of the precipitated particles,which contributed a lot to the microstrueture and hardness of this material.

  18. Transfer free graphene growth on SiO2 substrate at 250 °C

    Science.gov (United States)

    Vishwakarma, Riteshkumar; Rosmi, Mohamad Saufi; Takahashi, Kazunari; Wakamatsu, Yuji; Yaakob, Yazid; Araby, Mona Ibrahim; Kalita, Golap; Kitazawa, Masashi; Tanemura, Masaki

    2017-03-01

    Low-temperature growth, as well as the transfer free growth on substrates, is the major concern of graphene research for its practical applications. Here we propose a simple method to achieve the transfer free graphene growth on SiO2 covered Si (SiO2/Si) substrate at 250 °C based on a solid-liquid-solid reaction. The key to this approach is the catalyst metal, which is not popular for graphene growth by chemical vapor deposition. A catalyst metal film of 500 nm thick was deposited onto an amorphous C (50 nm thick) coated SiO2/Si substrate. The sample was then annealed at 250 °C under vacuum condition. Raman spectra measured after the removal of the catalyst by chemical etching showed intense G and 2D peaks together with a small D and intense SiO2 related peaks, confirming the transfer free growth of multilayer graphene on SiO2/Si. The domain size of the graphene confirmed by optical microscope and atomic force microscope was about 5 μm in an average. Thus, this approach will open up a new route for transfer free graphene growth at low temperatures.

  19. 基于PLC的XS-ZY250A注塑机控制系统设计

    Institute of Scientific and Technical Information of China (English)

    魏强

    2010-01-01

    为改善注塑机传统电气控制存在的局限性和不足,采用西门子S7-300型系列PLC对XS-ZY250A普通卧式注塑机控制系统进行改造.阐述了PLC控制系统程序设计,给出了XS-ZY250A注塑机的PLC控制梯形图.

  20. 时速250km以上高速列车制动模式曲线算法%Braking mode curve arithmetic of high-speed train above 250 km · h-1

    Institute of Scientific and Technical Information of China (English)

    上官伟; 蔡伯根; 王晶晶; 王剑; 王利

    2011-01-01

    The braking system of high-speed train above 250 km ? H-1 was studied, and the running resistance, braking force and braking distance of high-speed train were analyzed. Based on curve theory of target distance mode, the piecewise iteration model of braking mode curve for high-speed train was proposed. With MATLAB/Simulink software, the changes of running resistances on flat-straight line, direct ramp with grade 15%o and direct ramp with grade 25‰ for CRH2-300 type high-speed train were analyzed, and the normal braking curves and emergency braking curves of CRH2-300 type and CRH3 type high-speed trains at initial braking speed 300 km ? H-1 were compared. Calculation result indicates that the emergency braking distance of CRH2-300 type high-speed train is 2 786. 68 m on direct ramp, the emergency braking distance of CRH3 type high-speed train is 3 319. 37 m on direct ramp, and both of them are less than 3 700 m, which is the maximum braking distance of braking requirement. Simulation braking curves almost consistent with actual braking curves, which verifies the validity of piecewise iteration algorithm. 1 tab, 12 figs, 10 refs.%研究了时速250 km以上高速列车制动系统,分析了高速列车的运行阻力、制动力与制动距离.根据目标距离模式曲线理论,建立了高速列车的制动模式曲线分段迭代模型.应用MAT-LAB/Simulink软件,分析了CRH2-300型高速列车在平直道上、15‰与25‰直坡道上的运行阻力的变化,对比了CRH2-300型和CRH3型高速列车在制动初速为300 km·h-1时的常用和紧急制动曲线.计算结果表明:在平直道上,CRH2-300型高速列车紧急制动距离为2 786.68 m,CRH3型高速列车紧急制动距离为3 319.37 m,均满足紧急制动距离小于3 700 m的制动要求;仿真制动曲线和实际制动曲线基本一致,验证了分段迭代算法的有效性.

  1. Commissioning a Rotating Target Wheel Assembly for Heavy Element Studies

    Science.gov (United States)

    Fields, L. D.; Bennett, M. E.; Mayorov, D. A.; Folden, C. M.

    2013-10-01

    The heaviest elements are produced artificially by fusing nuclei of light elements within an accelerator to form heavier nuclei. The most direct method to increase the production rate of nuclei is to increase the beam intensity, necessitating the use of a rotating target to minimize damage to the target by deposited heat. Such a target wheel was constructed for heavy element research at Texas A&M University, Cyclotron Institute, consisting of a wheel with three banana-shaped target cutouts. The target is designed to rotate at 1700 rpm, and a fiber optic cable provides a signal to trigger beam pulsing in order to avoid irradiating the spokes between target segments. Following minor mechanical modifications and construction of a dedicated electrical panel, the rotating target assembly was commissioned for a beam experiment. A 15 MeV/u beam of 20Ne was delivered from the K500 cyclotron and detected by a ruggedized silicon detector. The beam pulsing response time was characterized as a function of the rational frequency of the target wheel. Preliminary analysis suggests that the K500 is capable of pulsing at rates of up to 250 Hz, which is sufficient for planned future experiments. Funded by DOE and NSF-REU Program.

  2. Targeted tumor radiotherapy

    Directory of Open Access Journals (Sweden)

    Unak Perihan

    2002-01-01

    Full Text Available Targeted tumor radiotherapy is selectively delivery of curative doses of radiation to malignant sites. The aim of the targeted tumor radiotherapy is to use the radionuclides which have high LET particle emissions conjugated to appropriate carrier molecules. The radionuclides are selectively collected by tumor cells, depositing lethal doses to tumor cells while no admission occur to normal cells. In theory, targeted radiotherapy has several advantages over conventional radiotherapy since it allows a high radiation dose to be administered without causing normal tissue toxicity, although there are some limitations in the availability of appropriate targeting agents and in the calculations of administered doses. Therefore, for routine clinical applications more progress is still needed. In this article, the potential use of targeted tumor radiotherapy is briefly reviewed. More general aspects and considerations, such as potential radionuclides, mechanisms of tumor targeting was also outlined.

  3. Targeting Notch to target cancer stem cells.

    Science.gov (United States)

    Pannuti, Antonio; Foreman, Kimberly; Rizzo, Paola; Osipo, Clodia; Golde, Todd; Osborne, Barbara; Miele, Lucio

    2010-06-15

    The cellular heterogeneity of neoplasms has been at the center of considerable interest since the "cancer stem cell hypothesis", originally formulated for hematologic malignancies, was extended to solid tumors. The origins of cancer "stem" cells (CSC) or tumor-initiating cells (TIC; henceforth referred to as CSCs) and the methods to identify them are hotly debated topics. Nevertheless, the existence of subpopulations of tumor cells with stem-like characteristics has significant therapeutic implications. The stem-like phenotype includes indefinite self-replication, pluripotency, and, importantly, resistance to chemotherapeutics. Thus, it is plausible that CSCs, regardless of their origin, may escape standard therapies and cause disease recurrences and/or metastasis after apparently complete remissions. Consequently, the idea of selectively targeting CSCs with novel therapeutics is gaining considerable interest. The Notch pathway is one of the most intensively studied putative therapeutic targets in CSC, and several investigational Notch inhibitors are being developed. However, successful targeting of Notch signaling in CSC will require a thorough understanding of Notch regulation and the context-dependent interactions between Notch and other therapeutically relevant pathways. Understanding these interactions will increase our ability to design rational combination regimens that are more likely to prove safe and effective. Additionally, to determine which patients are most likely to benefit from treatment with Notch-targeting therapeutics, reliable biomarkers to measure pathway activity in CSC from specific tumors will have to be identified and validated. This article summarizes the most recent developments in the field of Notch-targeted cancer therapeutics, with emphasis on CSC.

  4. The ISOLDE target robots

    CERN Multimedia

    Maximilein Brice

    2002-01-01

    ISOLDE targets need to be changed frequently, around 80 times per year. The high radiation levels do not permit this to be done by human hands and the target changes are effected by 2 industrial robots (picture _01). On the left, in the distance, the front-end of the GPS (General Purpose Separator) is seen, while the HRS (High Resolution Separator) is at the right. Also seen are the doors to the irradiated-target storage.

  5. Target Window Reliability

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-02-11

    The target window design implemented and tested in experiments at ANL have performed without failure for the available beam of 6 mm FWHM on a 12 mm diameter target. However, scaling that design to a 25 mm diameter target size for a 12 mm FWHM beam has proven problematic. Combined thermal and mechanical (pressure induced) stresses and strains are too high to maintain the small coolant gaps and provide adequate fatigue lifetime.

  6. Moving Target Defense

    CERN Document Server

    Jajodia, Sushil; Swarup, Vipin; Wang, Cliff; Wang, X Sean

    2011-01-01

    Moving Target Defense: Creating Asymmetric Uncertainty for Cyber Threats was developed by a group of leading researchers. It describes the fundamental challenges facing the research community and identifies new promising solution paths. Moving Target Defense which is motivated by the asymmetric costs borne by cyber defenders takes an advantage afforded to attackers and reverses it to advantage defenders. Moving Target Defense is enabled by technical trends in recent years, including virtualization and workload migration on commodity systems, widespread and redundant network connectivity, instr

  7. Targeted Radionuclide Therapy

    Directory of Open Access Journals (Sweden)

    David Cheng

    2011-10-01

    Full Text Available Targeted radiotherapy is an evolving and promising modality of cancer treatment. The killing of cancer cells is achieved with the use of biological vectors and appropriate radionuclides. Among the many advantages of this approach are its selectiveness in delivering the radiation to the target, relatively less severe and infrequent side effects, and the possibility of assessing the uptake by the tumor prior to the therapy. Several different radiopharmaceuticals are currently being used by various administration routes and targeting mechanisms. This article aims to briefly review the current status of targeted radiotherapy as well as to outline the advantages and disadvantages of radionuclides used for this purpose.

  8. Bayesian multiple target tracking

    CERN Document Server

    Streit, Roy L

    2013-01-01

    This second edition has undergone substantial revision from the 1999 first edition, recognizing that a lot has changed in the multiple target tracking field. One of the most dramatic changes is in the widespread use of particle filters to implement nonlinear, non-Gaussian Bayesian trackers. This book views multiple target tracking as a Bayesian inference problem. Within this framework it develops the theory of single target tracking, multiple target tracking, and likelihood ratio detection and tracking. In addition to providing a detailed description of a basic particle filter that implements

  9. Target Assembly Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Target Assembly Facility integrates new armor concepts into actual armored vehicles. Featuring the capability ofmachining and cutting radioactive materials, it...

  10. Targeting the tumor microenvironment

    Energy Technology Data Exchange (ETDEWEB)

    Kenny, P.A.; Lee, G.Y.; Bissell, M.J.

    2006-11-07

    Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have been proposed. The FDA has already approved drugs targeting microenvironmental components such as VEGF and aromatase and many more agents are in the pipeline. In this article, we describe some of the 'druggable' targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions.

  11. 30 CFR 250.201 - What plans and information must I submit before I conduct any activities on my lease or unit?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What plans and information must I submit before I conduct any activities on my lease or unit? 250.201 Section 250.201 Mineral Resources MINERALS... CONTINENTAL SHELF Plans and Information General Information § 250.201 What plans and information must I...

  12. Fabrication of 250-nm-hole arrays in glass and fused silica by UV laser ablation

    Science.gov (United States)

    Karstens, R.; Gödecke, A.; Prießner, A.; Ihlemann, J.

    2016-09-01

    Parallel nanohole drilling in glass using an ArF excimer laser (193 nm) is demonstrated. For the first time, hole arrays with 500 nm pitch and individual holes with 250 nm diameter and more than 100 nm depth are fabricated by phase mask imaging using a Schwarzschild objective. Holes in soda lime glass are drilled by direct ablation; fused silica is processed by depositing a SiOx-film on SiO2, patterning the SiOx by ablation, and finally oxidizing the remaining SiOx to SiO2. Thermally induced ordered dewetting of noble metal films deposited on such templates may be used for the fabrication of plasmonic devices.

  13. 环保践行者 Mercedes-Benz C 250 CDI Blue Efficiency Prime Edition

    Institute of Scientific and Technical Information of China (English)

    雅坤

    2008-01-01

    作为国际车坛中著名的品牌之一,梅赛德斯-奔驰从2008年初就提出了Blue Efficiency(环保高效动力)概念,而随着能源问题和环境污染问题的日益严重,消费者对节能环保车型的关注度也越来越高,为顺应车市发展方向,奔驰推出了一款更节能更环保的C 250 CDI Blue Efficiency领先版车型。

  14. Evidence for general instability of past climate from a 250-KYR ice-core record

    DEFF Research Database (Denmark)

    Johnsen, Sigfus Johann; Clausen, Henrik Brink; Dahl-Jensen, Dorthe;

    1993-01-01

     results1,2 from two ice cores drilled in central Greenland have revealed large, abrupt climate changes of at least regional extent during the late stages of the last glaciation, suggesting that climate in the North Atlantic region is able to reorganize itself rapidly, perhaps even within a few...... decades. Here we present a detailed stable-isotope record for the full length of the Greenland Ice-core Project Summit ice core, extending over the past 250 kyr according to a calculated timescale. We find that climate instability was not confined to the last glaciation, but appears also to have been...... marked during the last interglacial (as explored more fully in a companion paper3) and during the previous Saale-Holstein glacial cycle. This is in contrast with the extreme stability of the Holocene, suggesting that recent climate stability may be the exception rather than the rule. The last...

  15. Development of Regional TSS Algorithm over Penang using Modis Terra (250 M Surface Reflectance Product

    Directory of Open Access Journals (Sweden)

    Amin Abd Rahman Mat

    2016-09-01

    Full Text Available Total suspended sediment (TSS plays a significant role in the environment. Many researchers show that TSS has a high correlation with the red portion of the visible light spectrum. The correlation is highly dependent on geography of the study area. The aim of this study was to develop specific algorithms utilizing corrected MODIS Terra 250-m surface reflectance (Rrs product (MOD09 to map TSS over the Penang coastal area. Field measurements of TSS were performed during two cruise trips that were conducted on 8 December 2008 and 29 January 2010 over the Penang coastal area. The relationship between TSS and the surface reflectance of MOD09 was analysed using regression analysis. The developed algorithm showed that Rrs are highly correlated with the in-situ TSS with R2 is 0.838. The result shows that the Rrs product could be used to estimate TSS over the Penang area.

  16. Three-dimensional magnetic cloak working from DC to 250 kHz

    CERN Document Server

    Zhu, Jianfei; Liu, Yichao; Yin, Ge; Yuan, Jun; He, Sailing; Ma, Yungui

    2015-01-01

    Invisible cloaking is one of major outcomes of the metamaterial research, but the practical potential, in particular for high frequencies (e.g., microwave to visible light), is fatally challenged by the complex material properties they usually demand. On the other hand, it will be advantageous and also technologically instrumental to design cloaking devices for applications at low frequencies where electromagnetic components are favorably uncoupled. In this work, we vastly develop the bilayer approach to create a three-dimensional magnetic cloak able to work in both static and dynamic fields. Under the quasi-static approximation, we demonstrate a perfect magnetic cloaking device with a large frequency band from zero to 250 kHz. The practical potential of our device is experimentally verified by using a commercial metal detector, which may lead us to having a real cloaking application where the dynamic magnetic field can be manipulated in desired ways.

  17. Familiar words capture the attention of 11-month-olds in less than 250 ms.

    Science.gov (United States)

    Thierry, Guillaume; Vihman, Marilyn; Roberts, Mark

    2003-12-19

    The capacity of human infants to discriminate contrasting speech sounds specializes to the native language by the end of the first year of life, when the first signs of word recognition have also been found, using behavioural measures. The extent of voluntary attentional involvement in such word recognition has not been explored, however, nor do we know what its neural time-course may be. Here we demonstrate that 11-month-old children shift their attention automatically to familiar words within 250 ms of presentation onset by measuring event-related potentials elicited by familiar and unfamiliar words. A significant modulation of the first negative peak (N200), known to index implicit change detection in adults, was induced by word familiarity in the infants.

  18. Preequilibrium particle emission in 250 MeV {sup 16}O + {sup 116}Sn reaction

    Energy Technology Data Exchange (ETDEWEB)

    Barlini, S.; Kravchuk, V.L.; Gramegna, F. [INFN, Laboratori Nazionali di Legnaro Padova (Italy)] (and others)

    2005-07-01

    A certain progress in understanding the phenomenon of the Preequilibrium (fast) light charged particle and neutron Emission (PE) was achieved in the last two decades. However, there is a strong need to study systematically the dependence of the PE emission on the reaction mass asymmetry and the projectile energy. In the present work we present the results on the PE proton and alpha-particle multiplicities and the total energy loss of the composite system formed in fusion reaction E{sub b}eam=250 MeV (15.6 MeV/u) {sup 16}O + {sup 116}Sn. The experiment was performed at the Legnaro National Laboratory using a 1 ns (FWHM) pulsed beam provided by the TANDEM-ALPI acceleration system.

  19. Structure function scaling in a Reλ = 250 turbulent mixing layer

    KAUST Repository

    Attili, Antonio

    2011-12-22

    A highly resolved Direct Numerical Simulation of a spatially developing turbulent mixing layer is presented. In the fully developed region, the flow achieves a turbulent Reynolds number Reλ = 250, high enough for a clear separation between large and dissipative scales, so for the presence of an inertial range. Structure functions have been calculated in the self-similar region using velocity time series and Taylor\\'s frozen turbulence hypothesis. The Extended Self-Similarity (ESS) concept has been employed to evaluate relative scaling exponents. A wide range of scales with scaling exponents and intermittency levels equal to homogeneous isotropic turbulence has been identified. Moreover an additional scaling range exists for larger scales; it is characterized by smaller exponents, similar to the values reported in the literature for flows with strong shear.

  20. Snow Cover Maps from MODIS Images at 250 m Resolution, Part 2: Validation

    Directory of Open Access Journals (Sweden)

    Marc Zebisch

    2013-03-01

    Full Text Available The performance of a new algorithm for binary snow cover monitoring based on Moderate Resolution Imaging Spectroradiometer (MODIS satellite images at 250 m resolution is validated using snow cover maps (SCA based on Landsat 7 ETM+ images and in situ snow depth measurements from ground stations in selected test sites in Central Europe. The advantages of the proposed algorithm are the improved ground resolution of 250 m and the near real-time availability with respect to the 500 m standard National Aeronautics and Space Administration (NASA MODIS snow products (MOD10 and MYD10. It allows a more accurate snow cover monitoring at a local scale, especially in mountainous areas characterized by large landscape heterogeneity. The near real-time delivery makes the product valuable as input for hydrological models, e.g., for flood forecast. A comparison to sixteen snow cover maps derived from Landsat ETM/ETM+ showed an overall accuracy of 88.1%, which increases to 93.6% in areas outside of forests. A comparison of the SCA derived from the proposed algorithm with standard MODIS products, MYD10 and MOD10, indicates an agreement of around 85.4% with major discrepancies in forested areas. The validation of MODIS snow cover maps with 148 in situ snow depth measurements shows an accuracy ranging from 94% to around 82%, where the lowest accuracies is found in very rugged terrain restricted to in situ stations along north facing slopes, which lie in shadow in winter during the early morning acquisition.

  1. Vibrotactile target saliency

    NARCIS (Netherlands)

    Toet, A.; Groen, E.l.; Oosterbeek, M.T.J.; Hooge, I.T.C.

    2008-01-01

    We tested the saliency of a single vibrotractile target (T) among 2 to 7 nontargets (N), presented by 8 tactors that were equally distributed over a horizontal band around the torso. Targets and nontargets had different pulse duration, but the same activation period and no onset asynchrony. T-N simi

  2. Strategic Targeted Advertising

    NARCIS (Netherlands)

    A. Galeotti; J.L. Moraga-Gonzalez (José Luis)

    2003-01-01

    textabstractWe present a strategic game of pricing and targeted-advertising. Firms can simultaneously target price advertisements to different groups of customers, or to the entire market. Pure strategy equilibria do not exist and thus market segmentation cannot occur surely. Equilibria exhibit rand

  3. The CNGS target

    CERN Multimedia

    Patrice Loïez

    2005-01-01

    The CERN Neutrinos to Gran Sasso (CNGS) target ‘magazine’ of five target units. Each unit contains a series of 10-cm long graphite rods distributed over a length of 2 m. It is designed to maximize the number of secondary particles produced and hence the number of neutrinos. One unit is used at a time to prevent over heating.

  4. Nuclear target development

    Energy Technology Data Exchange (ETDEWEB)

    Greene, J.P.; Thomas, G.E.

    1995-08-01

    The Physics Division operates a target development laboratory that produces thin foil targets needed for experiments performed at the ATLAS and Dynamitron accelerators. Targets are not only produced for the Physics Division but also for other divisions and occasionally for other laboratories and universities. In the past year, numerous targets were fabricated by vacuum evaporation either as self-supporting foils or on various substrates. Targets produced included Ag, Au, {sup 10,11}B, {sup 138}Ba, Be, {sup 12}C, {sup 40}Ca, {sup 116}Cd, {sup 155,160}Gd, {sup 76}Ge, In, LID, {sup 6}LiH, Melamine, Mg, {sup 142,150}Nd, {sup 58}Ni, {sup 206,208}Pb, {sup 194}Pt, {sup 28}Si, {sup 144,148}Sm, {sup 120,122,124}Sn, Ta, {sup 130}Te, ThF{sub 4}, {sup 46,50}Ti, TiH, U, UF{sub 4}, {sup 182}W and {sup 170}Yb. Polypropylene and aluminized polypropylene, along with metallized Mylar were produced for experiments at ATLAS. A number of targets of {sup 11}B of various thickness were made for the DEP 2-MeV Van de Graff accelerator. An increased output of foils fabricated using our small rolling mill included targets of Au, C, {sup 50}Cr, Cu, {sup 155,160}Gd, Mg, {sup 58}Ni, {sup 208}Pb, {sup 105,110}Pd. Sc, Ti, and {sup 64,66}Zn.

  5. AA antiproton production target

    CERN Multimedia

    1979-01-01

    The first version of the antiproton production target was a tungsten rod, 11 cm long and 3 mm in diameter. The rod was embedded in graphite, pressure-seated into an outer casing of stainless steel. At the entrance to the target assembly was a scintillator screen, imprinted with circles every 5 mm in radius, which allowed to precisely aim the 26 GeV high-intensity proton beam from the PS onto the centre of the target rod. The scintillator screen was a 1 mm thick plate of Cr-doped alumina. See also 7903034 and 7905091.

  6. Internal polarized targets

    Energy Technology Data Exchange (ETDEWEB)

    Kinney, E.R.; Coulter, K.; Gilman, R.; Holt, R.J.; Kowalczyk, R.S.; Napolitano, J.; Potterveld, D.H.; Young, L. (Argonne National Lab., IL (USA)); Mishnev, S.I.; Nikolenko, D.M.; Popov, S.G.; Rachek, I.A.; Temnykh, A.B.; Toporkov, D.K.; Tsentalovich, E.P.; Wojtsekhowski, B.B. (AN SSSR, Novosibirsk (USSR). Inst. Yadernoj Fiziki)

    1989-01-01

    Internal polarized targets offer a number of advantages over external targets. After a brief review of the basic motivation and principles behind internal polarized targets, the technical aspects of the atomic storage cell will be discussed in particular. Sources of depolarization and the means by which their effects can be ameliorated will be described, especially depolarization by the intense magnetic fields arising from the circulating particle beam. The experience of the Argonne Novosibirsk collaboration with the use of a storage cell in a 2 GeV electron storage ring will be the focus of this technical discussion. 17 refs., 11 figs.

  7. STIS target acquisition

    Science.gov (United States)

    Kraemer, Steve; Downes, Ron; Katsanis, Rocio; Crenshaw, Mike; McGrath, Melissa; Robinson, Rich

    1997-01-01

    We describe the STIS autonomous target acquisition capabilities. We also present the results of dedicated tests executed as part of Cycle 7 calibration, following post-launch improvements to the Space Telescope Imaging Spectrograph (STIS) flight software. The residual pointing error from the acquisitions are < 0.5 CCD pixels, which is better than preflight estimates. Execution of peakups show clear improvement of target centering for slits of width 0.1 sec or smaller. These results may be used by Guest Observers in planning target acquisitions for their STIS programs.

  8. Influence of electroporation on immunogenicity of the DNA vaccine pVAX-tG250FcGB%电穿孔技术对DNA疫苗pVAX-tG250FcGB免疫效果的影响

    Institute of Scientific and Technical Information of China (English)

    肖毅; 于继云; 高昆; 杨勇; 阎瑾琦; 张亮; 王宇; 徐元基; 田仁礼; 杜芝燕

    2013-01-01

    Objective To investigate the influence of electroporation on the immunogenicity of the DNA vaccine pVAX-tG250FcGB. Methods The DNA vaccine pVAX-tG250FcGB was constructed by inserting the coding gene of tG250 fusion genes into the expression vector pVAX. The DNA vaccine was delivered in BALB/c mouse by electroporation or intramuscular injection, and the induced antigen specific immune responses were compared. Results The vaccine delivered by electroporation and intramuscular injection both induced immune responses in BALB/c mouse, but electroporation produced an obviously stronger effect than intramuscular injection. Conclusion Electroporation-mediated DNA vaccine delivery can produce strong immune response in mice and is an effective means for studying the immunogenic effect of DNA vaccine pVAX-tG250FcGB.%目的:探讨应用电穿孔技术对DNA疫苗pVAX-tG250FcGB免疫效果的影响。方法构建肾癌DNA疫苗pVAX-tG250FcGB,通过体内电穿孔技术或普通肌肉注射途径,将DNA疫苗导入到BALB/c小鼠体内,探讨电穿孔免疫途径诱导抗原特异性免疫应答的效果。结果电穿孔技术或普通肌肉注射均能在小鼠体内诱导出抗原特异性的体液免疫应答和细胞免疫应答,电穿孔技术的免疫效果明显优于普通肌肉注射途径。结论电穿孔技术介导的DNA疫苗pVAX-tG250FcGB免疫具有较强的诱导免疫应答的能力,是研究DNA疫苗pVAX-tG250FcGB免疫效果的一种有效途径。

  9. Preliminary methodology investigation of mask pattern fidelity for 250-nm design rules

    Science.gov (United States)

    Coleman, Thomas P.; Sauer, Charles A.; Naber, Robert J.; Hamaker, Henry Chris

    1995-07-01

    Techniques have been developed that can quickly and accurately measure corner rounding and contact fill as key indicators of pattern fidelity. Using these techniques, we have examined writing variables for their effect on the lithographic quality of 1.0 micrometers contact. A small contact is perhaps the most demanding figure to achieve, so the results shown can be considered the worst case for 4X radicle manufacturing at 250 nm design rules. A MEBES 4500 was used as the writing tool, using PBS resist on quartz masks. Standard printing methods, single-phase printing (SPP) and multiphase printing (2X MPP) were examined. Results indicate that excellent corner rounding results can be achieved with small address sizes, regardless of the writing strategy or the dose used. As expected, larger spot sizes increase the amount of corner rounding, regardless of the address. As the pattern address is increased, judicious choices of spot size reduce potential pattern fidelity loss when imaging small contracts and other fine features. Multiphase printing is a technique that offers advantages to the user. Its use of offset scan voting (OSV) is a significant factor in reducing placement errors. MPP (2X) has an additional advantage of providing higher dosages. This provides flexibility in resist choices and in the selection of a process window. With 2X MPP, the user has a wide range of addresses and spot sizes that will give excellent results. The dynamic range of operating conditions possible with 2X MPP when writing 1.0 micrometers contacts is a reduced subset of those available using SPP, due to the 2X writing grid (output address). Implementation of 2X MPP has been limited on previous MEBES models due to increased write times of multipass writing. The MEBES 4500 data path supports 2X MPP with write times that approximate SPP. The practical operating envelope of both writing strategies are detailed in this paper. Overall, the MEBES 4500 has a large dynamic operating range. When

  10. Crop Dominance Mapping with IRS-P6 and MODIS 250-m Time Series Data

    Directory of Open Access Journals (Sweden)

    Murali Krishna Gumma

    2014-04-01

    Full Text Available This paper describes an approach to accurately separate out and quantify crop dominance areas in the major command area in the Krishna River Basin. Classification was performed using IRS-P6 (Indian Remote Sensing Satellite, series P6 and MODIS eight-day time series remote sensing images with a spatial resolution of 23.6 m, 250 m for the year 2005. Temporal variations in the NDVI (Normalized Difference Vegetation Index pattern obtained in crop dominance classes enables a demarcation between long duration crops and short duration crops. The NDVI pattern was found to be more consistent in long duration crops than in short duration crops due to the continuity of the water supply. Surface water availability, on the other hand, was dependent on canal water release, which affected the time of crop sowing and growth stages, which was, in turn, reflected in the NDVI pattern. The identified crop-wise classes were tested and verified using ground-truth data and state-level census data. The accuracy assessment was performed based on ground-truth data through the error matrix method, with accuracies from 67% to 100% for individual crop dominance classes, with an overall accuracy of 79% for all classes. The derived major crop land areas were highly correlated with the sub-national statistics with R2 values of 87% at the mandal (sub-district level for 2005–2006. These results suggest that the methods, approaches, algorithms and datasets used in this study are ideal for rapid, accurate and large-scale mapping of paddy rice, as well as for generating their statistics over large areas. This study demonstrates that IRS-P6 23.6-m one-time data fusion with MODIS 250-m time series data is very useful for identifying crop type, the source of irrigation water and, in the case of surface water irrigation, the way in which it is applied. The results from this study have assisted in improving surface water and groundwater irrigated areas of the command area and also

  11. Investigation of Murine Models for Sleep, Wakefulness and Target Discovery

    Science.gov (United States)

    2007-10-01

    subjective day, 7pm-7am w R NR 0 50 100 150 200 250 state c o u n t s F2 Females F2 Males Different from humans, mice exhibit polyphasic sleep with many...early trends, e.g., in the 1p.m. (6 hrs of subjective night) group, became non-significant with additional mice tested • The polyphasic sleep ...REPORT Final report - Investigation of Murine Models for Sleep , Wakefulness and Target Discovery 14. ABSTRACT 16. SECURITY CLASSIFICATION OF

  12. Target Price Accuracy

    Directory of Open Access Journals (Sweden)

    Alexander G. Kerl

    2011-04-01

    Full Text Available This study analyzes the accuracy of forecasted target prices within analysts’ reports. We compute a measure for target price forecast accuracy that evaluates the ability of analysts to exactly forecast the ex-ante (unknown 12-month stock price. Furthermore, we determine factors that explain this accuracy. Target price accuracy is negatively related to analyst-specific optimism and stock-specific risk (measured by volatility and price-to-book ratio. However, target price accuracy is positively related to the level of detail of each report, company size and the reputation of the investment bank. The potential conflicts of interests between an analyst and a covered company do not bias forecast accuracy.

  13. Issues in Target Tracking

    Science.gov (United States)

    2010-05-01

    the CUSUM (Page) test yields the quickest detection of a change of distribution for the case of i.i.d. observations [3]. In fact, in a (highly...11. Autocorrelation of the CUSUM increments, sn, under H1 (target present). Issues in Target Tracking RTO-EN-SET-157(2010...restrictive condition that the increments of the cumulative sum, sn, be i.i.d. [3], [22]. Fig. 11 plots the autocorrelation of the CUSUM increments as a

  14. Corrigendum to "Geant4 validation of neutron production on thick targets bombarded with 120 GeV protons" [Nucl. Instr. Meth. B 358 (2015) 245-250

    Science.gov (United States)

    Sabra, Mohammad S.

    2016-09-01

    In the paper by Mohammad S. Sabra, due to a mixup, wrong calculations for NEPR ratios, normalized to 20 cm-thick copper, for 40 cm and 60 cm-thick copper at 30° for QGSP-BIC, QGSP-BERT, QGSP-INCLXX, and SHIELDING were published in Table 2. The correct values are listed in the revised Table 2 as below.

  15. An ISOLDE target unit

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    A good dozen different targets are available for ISOLDE, made of different materials and equipped with different kinds of ion-sources, according to the needs of the experiments. Each separator (GPS: general purpose; HRS: high resolution) has its own target. Because of the high radiation levels, robots effect the target changes, about 80 times per year. In the standard unit shown in picture _01, the target is the cylindrical object in the front. It contains uranium-carbide kept at a temperature of 2200 deg C, necessary for the isotopes to be able to escape. At either end, one sees the heater current leads, carrying 700 A. The Booster beam, some 3E13 protons per pulse, enters the target from left. The evaporated isotope atoms enter a hot-plasma ion source (the black object behind the target). The whole unit sits at 60 kV potential (pulsed in synchronism with the arrival of the Booster beam) which accelerates the ions (away from the viewer) towards one of the 2 separators.

  16. Neanderthal use of fish, mammals, birds, starchy plants and wood 125-250,000 years ago.

    Directory of Open Access Journals (Sweden)

    Bruce L Hardy

    Full Text Available Neanderthals are most often portrayed as big game hunters who derived the vast majority of their diet from large terrestrial herbivores while birds, fish and plants are seen as relatively unimportant or beyond the capabilities of Neanderthals. Although evidence for exploitation of other resources (small mammals, birds, fish, shellfish, and plants has been found at certain Neanderthal sites, these are typically dismissed as unusual exceptions. The general view suggests that Neanderthal diet may broaden with time, but that this only occurs sometime after 50,000 years ago. We present evidence, in the form of lithic residue and use-wear analyses, for an example of a broad-based subsistence for Neanderthals at the site of Payre, Ardèche, France (beginning of MIS 5/end of MIS 6 to beginning of MIS 7/end of MIS 8; approximately 125-250,000 years ago. In addition to large terrestrial herbivores, Neanderthals at Payre also exploited starchy plants, birds, and fish. These results demonstrate a varied subsistence already in place with early Neanderthals and suggest that our ideas of Neanderthal subsistence are biased by our dependence on the zooarchaeological record and a deep-seated intellectual emphasis on big game hunting.

  17. Neanderthal use of fish, mammals, birds, starchy plants and wood 125-250,000 years ago.

    Science.gov (United States)

    Hardy, Bruce L; Moncel, Marie-Hélène

    2011-01-01

    Neanderthals are most often portrayed as big game hunters who derived the vast majority of their diet from large terrestrial herbivores while birds, fish and plants are seen as relatively unimportant or beyond the capabilities of Neanderthals. Although evidence for exploitation of other resources (small mammals, birds, fish, shellfish, and plants) has been found at certain Neanderthal sites, these are typically dismissed as unusual exceptions. The general view suggests that Neanderthal diet may broaden with time, but that this only occurs sometime after 50,000 years ago. We present evidence, in the form of lithic residue and use-wear analyses, for an example of a broad-based subsistence for Neanderthals at the site of Payre, Ardèche, France (beginning of MIS 5/end of MIS 6 to beginning of MIS 7/end of MIS 8; approximately 125-250,000 years ago). In addition to large terrestrial herbivores, Neanderthals at Payre also exploited starchy plants, birds, and fish. These results demonstrate a varied subsistence already in place with early Neanderthals and suggest that our ideas of Neanderthal subsistence are biased by our dependence on the zooarchaeological record and a deep-seated intellectual emphasis on big game hunting.

  18. Performances of 250 Amp-hr lithium/thionyl chloride cells

    Science.gov (United States)

    Goualard, Jacques

    1991-05-01

    A 250 Ah lithium thionyl chloride battery is being developed for a booster rocket engine. Extensive cell testing is running to evaluate functional and safety performances. Some results are presented. The lithium/thionyl chloride batteries were selected for their high energy density (low weight) as compared to other sources. The temperature of a lower weight item will be more sensitive to variations of internal and external heat fluxes than a heavier one. The use of high energy density L/TC batteries is subjected to stringent thermal environments to have benefit of energy density and to stay safe in any conditions. The battery thermal environment and discharge rate have to be adjusted to obtain the right temperature range at cell level, to have the maximum performances. Voltage and capacity are very sensitive to temperature. This temperature is the cell internal actual temperature during discharge. This temperature is directed by external thermal environment and by cell internal heat dissipation, i.e., cell actual voltage.

  19. The 250AH/90A active lithium-thionyl chloride cell for Centaur-G application

    Science.gov (United States)

    Zolla, A. E.; Tura, D. D.

    1987-09-01

    A high rate active Li/SOCl2 cell was designed for use in a 28 volt, 250 amp-hour space battery system. The lithium battery is being considered as a replacement of its heavier silver-zinc counterpart on board the Centaur-G booster rocket which is used to launch payloads from the Space Shuttle cargo bay into deep-space. Basically a feasibility study, this development effort is demonstrating the ability of the lithium cell to deliver up to 90 amps safely at power densities of approximately 25 watts per pound. Test data on 4 prototype units is showing an energy density of 85 watt-hours per pound and 9.0 watt-hours/cu in. The cells tested typically delivered 280 to 300 amp-hours under ambient temperature test conditions using alternating continuous loads of 90, 55, and 20 amperes throughout life. Data from four cells tested are presented to demonstrate the capability of Li/SOCl2 technology for a C/3 discharge rate in active and hermetic cell units.

  20. 250例新生儿脐血血脂水平调查

    Institute of Scientific and Technical Information of China (English)

    王燕; 汤明荣

    2010-01-01

    目的 了解健康足月新生儿脐带血血脂水平,为制订临床新生儿脂质代谢筛查参考标准提供实验依据.方法 采集250例健康足月新生儿脐血,应用全自动生化分析仪分别以酶法检测总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)的含量.结果 健康足月新生儿脐血TC、TG、LDL-C和HDL-C分别为(1.96±0.40)、(0.46±0.14)、(1.0±0.28)和(0.76±0.18) mmol/L.结论 足月新生儿脂质代谢筛查参考标准为TC>2.58 mmol/L,TG>0.75 mmol/L,LDL-C>2.03 mmol/L,HDL-C<0.33 mmol/L.

  1. Study on Laser Transformation Hardening of HT250 by High Speed Axis Flow CO2 Laser

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    In this article, laser transformation hardening of HT250 material by high speed axis flow CO2 laser was investigated for first time in China. Appropriate laser hardening parameters, such as laser energy power P(W), laser scanning rate V(m/min),were optimized through a number of experiments. The effect of the mentioned parameters on the hardened zone, including its case depth, microhardness distributions etc., were analyzed. Through the factual experiments, it is proved that axial flow CO2 laser, which commonly outputs low mode laser beam, can also treat materials as long as the treating parameters used are rational. During the experiments, the surface qualities of some specimens treated by some parameters were found to be enhanced, which does not coincide with the former results. Furthermore in the article, the abnormal phenomenon observed in the experiments is discussed. According to the experimental results, the relationship between laser power density q and scanning rate V is shown in a curve and the corresponding formulation, which have been proved to be valuable for choosing the parameters of laser transformation hardening by axial flow CO2 lasers, was also given.

  2. Partial covering of emission regions of Q 0528-250 by intervening H$_2$ clouds

    CERN Document Server

    Klimenko, V V; Ivanchik, A V; Ledoux, C; Noterdaeme, P; Petitjean, P; Srianand, R; Varshalovich, D A

    2015-01-01

    We present an analysis of the molecular hydrogen absorption system at z$_{\\rm abs}$ = 2.811 in the spectrum of the blazar Q0528-250. We demonstrate that the molecular cloud does not cover the background source completely. The partial coverage reveals itself as a residual flux in the bottom of saturated H_2 absorption lines. This amounts to about (2.22$\\pm$0.54)% of the continuum and does not depend on the wavelength. This value is small and it explains why this effect has not been detected in previous studies of this quasar spectrum. However, it is robustly detected and significantly higher than the zero flux level in the bottom of saturated lines of the Ly-alpha forest, (-0.21$\\pm$0.22)%. The presence of the residual flux could be caused by unresolved quasar multicomponents, by light scattered by dust, and/or by jet-cloud interaction. The H$_2$ absorption system is very well described by a two-component model without inclusion of additional components when we take partial coverage into account. The derived t...

  3. MUSE-INGS ON AM1354-250: COLLISIONS, SHOCKS, AND RINGS

    Energy Technology Data Exchange (ETDEWEB)

    Conn, Blair C. [Gemini Observatory, Recinto AURA, Colina El Pino, Casilla 603, La Serena (Chile); Fogarty, L. M. R. [Sydney Institute for Astronomy, School of Physics, The University of Sydney, A28, Sydney, 2006 (Australia); Smith, Rory [Yonsei University, Graduate School of Earth System Sciences-Astronomy-Atmospheric Sciences, Yonsei-ro 50, Seoul 120-749 (Korea, Republic of); Candlish, Graeme N., E-mail: bconn@gemini.edu [Departamento de Astronomía, Universidad de Concepción, Casilla 160-C, Concepción (Chile)

    2016-03-10

    We present Multi Unit Spectroscopic Explorer observations of AM1354-250, confirming its status as a collisional ring galaxy that has recently undergone an interaction, creating its distinctive shape. We analyze the stellar and gaseous emission throughout the galaxy finding direct evidence that the gaseous ring is expanding with a velocity of ∼70 km s{sup −1} and that star formation is occurring primarily in H ii regions associated with the ring. This star formation activity is likely triggered by this interaction. We find evidence for several excitation mechanisms in the gas, including emission consistent with shocked gas in the expanding ring and a region of LINER-like emission in the central core of the galaxy. Evidence of kinematic disturbance in both the stars and gas, possibly also triggered by the interaction, can be seen in all of the velocity maps. The ring galaxy retains a weak spiral structure, strongly suggesting the progenitor galaxy was a massive spiral prior to the collision with its companion an estimated 140 ± 12 Myr ago.

  4. Performances of 250 Amp-hr lithium/thionyl chloride cells

    Science.gov (United States)

    Goualard, Jacques

    1991-01-01

    A 250 Ah lithium thionyl chloride battery is being developed for a booster rocket engine. Extensive cell testing is running to evaluate functional and safety performances. Some results are presented. The lithium/thionyl chloride batteries were selected for their high energy density (low weight) as compared to other sources. The temperature of a lower weight item will be more sensitive to variations of internal and external heat fluxes than a heavier one. The use of high energy density L/TC batteries is subjected to stringent thermal environments to have benefit of energy density and to stay safe in any conditions. The battery thermal environment and discharge rate have to be adjusted to obtain the right temperature range at cell level, to have the maximum performances. Voltage and capacity are very sensitive to temperature. This temperature is the cell internal actual temperature during discharge. This temperature is directed by external thermal environment and by cell internal heat dissipation, i.e., cell actual voltage.

  5. Optical emission from a small scale model electric arc furnace in 250-600 nm region.

    Science.gov (United States)

    Mäkinen, A; Niskanen, J; Tikkala, H; Aksela, H

    2013-04-01

    Optical emission spectroscopy has been for long proposed for monitoring and studying industrial steel making processes. Whereas the radiative decay of thermal excitations is always taking place in high temperatures needed in steel production, one of the most promising environment for such studies are electric arc furnaces, creating plasma in excited electronic states that relax with intense characteristic emission in the optical regime. Unfortunately, large industrial scale electric arc furnaces also present a challenging environment for optical emission studies and application of the method is not straightforward. To study the usability of optical emission spectroscopy in real electric arc furnaces, we have developed a laboratory scale DC electric arc furnace presented in this paper. With the setup, optical emission spectra of Fe, Cr, Cr2O3, Ni, SiO2, Al2O3, CaO, and MgO were recorded in the wavelength range 250-600 nm and the results were analyzed with the help of reference data. The work demonstrates that using characteristic optical emission, obtaining in situ chemical information from oscillating plasma of electric arc furnaces is indeed possible. In spite of complications, the method could possibly be applied to industrial scale steel making process in order to improve its efficiency.

  6. Magnetic fields and beam optics studies of a 250 MeV superconducting proton radiotherapy cyclotron

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jong-Won [Research Institute and Hospital, National Cancer Center, 809 Madu-dong, Koyang, Kyonggi (Korea, Republic of)], E-mail: jwkim@ncc.re.kr

    2007-11-21

    A 250 MeV superconducting cyclotron for the proton radiation therapy was designed at the Michigan State University (MSU) for use at the Paul Scherrer Institut. This work was based on the conceptual design carried out at the MSU in 1994. The previous design was refined to finalize the magnet configuration and to optimally arrange cyclotron elements for the actual construction. The spiral angle of the pole was reduced, the new hill-edges and valley shims being introduced. The magnetic fields were highly isochronized using a least square fitting routine involving a schematic shimming scheme. The resulting reference field was adequate for the elaborate study of beam optics. The optics simulation predicted that extraction efficiency of above 80% was achievable for a beam with the initial phase width of 20{sup o}. The vertical deflector was investigated located in the central region to control the beam intensity with tracking of beam phase spaces. Some measurement results for the constructed cyclotron were found in a good agreement with those of the optics study.

  7. The Spectrum of Thorium from 250 nm to 5500 nm: Ritz Wavelengths and Optimized Energy Levels

    CERN Document Server

    Redman, Stephen L; Sansonetti, Craig J

    2013-01-01

    We have made precise observations of a thorium-argon hollow cathode lamp emission spectrum in the region between 350 nm and 1175 nm using a high-resolution Fourier transform spectrometer. Our measurements are combined with results from seven previously published thorium line lists (Giacchetti et al. 1974; Zalubas & Corliss 1974; Zalubas 1976; Palmer & Engleman 1983; Engleman et al. 2003; Lovis & Pepe 2007; Kerber et al. 2008) to re-optimize the energy levels of neutral, singly-, and doubly-ionized thorium (Th I, Th II, and Th III). Using the optimized level values, we calculate accurate Ritz wavelengths for 19679 thorium lines between 250 nm and 5500 nm (40000 1/cm to 1800 1/cm). We have also found 102 new thorium energy levels. A systematic analysis of previous measurements in light of our new results allows us to identify and propose corrections for systematic errors in Palmer & Engleman (1983) and typographical errors and incorrect classifications in Kerber et al. (2008). We also found a la...

  8. Updating the CSNS injector linac to 250 MeV with superconducting double-spoke cavities

    CERN Document Server

    Zhi-Hui, LI

    2014-01-01

    In order to update the beam power from 100 kW to 250 kW in China spallation neutron source (CSNS) Phase II, one of the important measures is to replace the 80 meters long beam transport line between the present 80 MeV linac injector and the RCS to another kind of acceleration structure. In this paper, we proposed a scheme based on 324 MHz double-spoke superconducting cavities. Unlike the superconducting elliptical cavity and normal conducting CCL structure, the double-spoke cavity belongs to TE mode structure and has smaller transvers dimension compared with that of TH mode one. It can work at base frequency as the DTL section, so that the cost and complexity of the RF system will be much decreased, and the behaviors of the beam dynamics are also improved significantly because of the low charge density and larger longitudinal acceptance. Furthermore, because of the relatively longer interactive length between charged particle and the electromagnetic field per cell, it needs relatively less cell numbers and it...

  9. Radiative properties of high wire number tungsten arrays with implosion times up to 250 ns

    Science.gov (United States)

    Deeney, C.; Coverdale, C. A.; Douglas, M. R.; Struve, K. W.; Spielman, R. B.; Stygar, W. A.; Peterson, D. L.; Roderick, N. F.; Haines, M. G.; Beg, F. N.; Ruiz-Camacho, J.

    1999-09-01

    High wire number, 25-mm-diameter tungsten wire arrays have been imploded on the 8-MA Saturn generator [R. B. Spielman et al., AIP Conference Proceeding 195, 3 (American Institute of Physics, Woodbury, NY 1989)], operating in a long-pulse mode. By varying the mass of the arrays from 710 to 6140 μg/cm, implosion times of 130-250 ns have been obtained with implosion velocities of 50-25 cm/μs, respectively. These Z-pinch implosions produced plasmas with millimeter diameters that radiated 600-800 kJ of x-rays, with powers of 20-49 TW; the corresponding pulsewidths were 19-7.5 ns, with risetimes ranging from 6.5 to 4.0 ns. These powers and pulsewidths are similar to those achieved with 50-ns implosion times on Saturn. Two-dimensional, radiation-magnetohydrodynamic calculations indicate that the imploding shells in these long implosion time experiments are comparable in width to those in the short-pulse cases. This can be due to lower initial perturbations. A heuristic wire array model suggests that the reduced perturbations, in the long-pulse cases, may be due to the individual wire merger occurring well before the acceleration of the shell. The experiments and modeling suggest that 150-200 ns implosion time Z-pinches could be employed for high-power, x-ray source applications.

  10. [Jonathan Swift's asylum in Dublin--Ireland's introduction to institutional psychiatry 250 years ago].

    Science.gov (United States)

    Reuber, M

    1995-09-01

    250 years ago, the satirical writer and clergyman Jonathan Swift from Dublin (1667-1745) founded the first Irish lunatic asylum. Rejecting the theories put forward by the English philosopher Thomas Hobbes and the doctor Thomas Willis, he was influenced by the ideas of the Scottish doctor and the "enlightened" thinker John Locke. Swift's St. Patrick's Hospital did not, however, realise a new philosophical concept: architecture and therapeutic approach of the new institution were clearly modelled on the much older Hospital of St. Mary of Bethlehem ( = Bedlam). Despite its conservative conceptual basis, the first institution dedicated to the mentally ill and intellectually subnormal in Ireland became a starting point for the apparantly unstoppable expansion of the, at one time, most comprehensive asylum system in the world. After Swift's Hospital had been enlarged twice at the tax-payers' expense (1778, 1793), the administration decided to relieve the institution by erecting the Richmond Asylum (1810), the first public asylum in Ireland. When this establishment also became overcrowded, in 1817, legislation was passed which led to the establishment of the oldest system of public asylums in Europe.

  11. MUSE-ings on AM1354-250: Collisions, Shocks and Rings

    CERN Document Server

    Conn, Blair C; Smith, Rory; Candlish, Graeme N

    2015-01-01

    We present MUSE observations of AM1354-250, confirming its status as a collisional ring galaxy which has recently undergone an interaction, creating its distinctive shape. We analyse the stellar and gaseous emission throughout the galaxy finding direct evidence that the gaseous ring is expanding with a velocity of $\\sim$70km.s$^{-1}$ and that star formation is occurring primarily in HII regions associated with the ring. This star formation activity is likely triggered by the interaction. We find evidence for several excitation mechanisms in the gas, including emission consistent with shocked gas in the expanding ring and a region of LINER-like emission in the central core of the galaxy. Evidence of kinematic disturbance in both the stars and gas, possibly also triggered by the interaction, can be seen in all of the velocity maps. The ring galaxy retains weak spiral structure, strongly suggesting the progenitor galaxy was a massive spiral prior to the collision with its companion an estimated $140 \\pm 12$ Myr ...

  12. A star forming ring around Kappa Ori 250 pc from the Sun

    CERN Document Server

    Pillitteri, I; Megeath, S T

    2016-01-01

    X-rays are a powerful probe of activity in early stages of star formation. They allow us to identify young stars even after they have lost the IR signatures of circumstellar disks and provide constraints on their distance. Here we report on XMM-Newton observations which detect 121 young stellar objects (YSOs) in two fields between L1641S and $\\kappa$ Ori. These observations extend the Survey of Orion A with XMM and Spitzer (SOXS). The YSOs are contained in a ring of gas and dust apparent at millimeter wavelengths, and in far-IR and near-IR surveys. The X-ray luminosity function of the young stellar objects detected in the two fields indicates a distance of 250-280 pc, much closer than the Orion A cloud and similar to distance estimates of $\\kappa$ Ori. We propose that the ring is a 5-8 pc diameter shell that has been swept up by $\\kappa$ Ori. This ring contains several groups of stars detected by Spitzer and WISE including one surrounding the Herbig Ae/Be stars V1818 Ori. In this interpretation, the $\\kappa$ ...

  13. FLUKA simulations and measurements for a dump for a 250 GeV/c hadron beam

    CERN Document Server

    Agosteo, S; Para, A; Silari, Marco; Ulrici, L

    2001-01-01

    FLUKA is a Monte Carlo code, transporting hadron and lepton cascades from several TeV down to a few keV (thermal energies for neutrons). The code is widely employed in various applications, such as particle detector design, shielding, radiation therapy, high energy physics experiments. The FLUKA results were compared with experimental data of dose equivalent and spectral fluence of neutrons produced by a 250 GeV/c proton/pion beam impinging on a beam dump installed in one of the secondary beam lines of the CERN super proton synchrotron (SPS). The dump is a shielding structure made of iron/concrete, designed to absorb completely the high-energy beam. The actual geometry of the clump was modeled in the simulations and the scoring of neutron track length was performed at various locations around it. Importance sampling and Russian Roulette mere used as variance reduction techniques. The simulations results were compared with experimental measurements performed with a Bonner sphere system for neutron spectrometry...

  14. A STAR-FORMING RING AROUND κ Ori 250 pc FROM THE SUN

    Energy Technology Data Exchange (ETDEWEB)

    Pillitteri, I.; Wolk, S. J. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Megeath, S. T., E-mail: ipillitt@cfa.harvard.edu [Ritter Astrophysical Research Center, Department of Physics and Astronomy, University of Toledo, Toledo, OH (United States)

    2016-04-01

    X-rays are a powerful probe of activity in early stages of star formation. They allow us to identify young stars even after they have lost the IR signatures of circumstellar disks and provide constraints on their distance. Here, we report on XMM-Newton observations that detect 121 young stellar objects (YSOs) in two fields between L1641 S and κ Ori. These observations extend the Survey of Orion A with XMM and Spitzer (SOXS). The YSOs are contained in a ring of gas and dust apparent at millimeter wavelengths, and in far-IR and near-IR surveys. The X-ray luminosity function of the YSOs detected in the two fields indicates a distance of 250–280 pc, much closer than the Orion A cloud and similar to distance estimates of κ Ori. We propose that the ring is a 5–8 pc diameter shell that has been swept up by κ Ori. This ring contains several groups of stars detected by Spitzer and WISE including one surrounding the Herbig Ae/Be stars V1818 Ori. In this interpretation, the κ Ori ring is one of several shells swept up by massive stars within the Orion Eridanus Superbubble and is unrelated to the southern portion of Orion A/L1641 S.

  15. Application of CMT Cold Metal Transfer Welding Technology in HT250 Repair Welding%CMT冷金属过渡焊接技术在HT250灰铸铁补焊中的应用

    Institute of Scientific and Technical Information of China (English)

    杨新华; 管志花

    2013-01-01

    阐述了利用CMT冷金属过渡方法补焊HT250灰铸铁的焊接工艺及补焊结果,主要从CMT冷金属过渡方法的特点、HT250灰铸铁焊接工艺和补焊质量3个方面进行了论述和试验研究,总结CMT自动焊技术在补焊铸铁方面的经验,为灰铸铁铸件的补焊提供科学依据和技术参考.%The welding process and the welding result of HT250 gray cast iron using CMT cold metal transfer welding methods were described,that is mainly discussed and researched from three aspects of the characteristics of CMT cold metal transfer method,welding process and welding quality of HT250 gray cast iron.The experience of CMT automatic welding technology in welding of cast iron was summarized,which provide scientific basis and technical references for repair welding of grey iron castings.

  16. 合成大麻素JWH-250的高效液相色谱分析方法研究%Determination of Synthetic Cannabinoid JWH-250 by HPLC

    Institute of Scientific and Technical Information of China (English)

    苗翠英; 邱志远; 翟晚枫; 魏巍; 全雪峰; 王兆玉

    2015-01-01

    Objective As one kind of the most popular designer drugs, synthetic cannabinoid has been presenting a tough challenge for law enforcement and public security officials. JWH-250, one of the phenacyl-indoles abused all around the world, has recently been included under the latest Psychotropic Drug Directory by Chinese government. In order to improve the accuracy and sensitivity of determining JWH-250 in actual cases and enrich the research means for this drug, high performance liquid chromatography (HPLC) was utilized. Methods Chromatographic parameters were tested and optimized based on the performance of least interference to the results quality and repeatedness, together with the ascertainment of linear relationship, precision and stability. Eventually, the ideal conditions for detection of the synthetic cannabinoid JWH-250 by HPLC were established. Results Under optimized conditions (UV wavelength at 214 nm, initial concentration of the organic phase of 63%, gradient steepness of 4.2%/min, flow rate of 0.8 mL/min, and column temperature of 34°C), a good linearity was achieved over the range of 2~100 μg/ml, with the correlation coefficient R=0.9999649 and limit of detection(S/N≥3) as to 0.1 μg/mL. The precision was good with the intra-day and inter-day RSDs less than 0.59% and 1.74%, respectively. JWH-250 can be completely separated from Δ9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD). Conclusions The method is rapid, sensitive and accurate, applicable to quantitative determination of the synthetic cannabinoid JWH-250 by validation experiment of a sample from an actual case, a promising choice for providing technical support to prevent and combat the drug-related criminal activities.%目的:建立合成大麻素 JWH-250的高效液相色谱分析方法。方法考查梯度洗脱的有机相初始浓度和梯度洗脱的陡度、流速、柱温、检测波长等参数,初步建立 JWH250的高效液相色谱分析方法,并对专

  17. The Sinuous Target

    Energy Technology Data Exchange (ETDEWEB)

    Zwaska, R. [Fermilab

    2015-06-01

    We report on the concept for a target material comprised of a multitude of interlaced wires of small dimension. This target material concept is primarily directed at high-power neutrino targets where the thermal shock is large due to small beam sizes and short durations; it also has applications to other high-power targets, particularly where the energy deposition is great or a high surface area is preferred. This approach ameliorates the problem of thermal shock by engineering a material with high strength on the micro-scale, but a very low modulus of elasticity on the meso-scale. The low modulus of elasticity is achieved by constructing the material of spring-like wire segments much smaller than the beam dimension. The intrinsic bends of the wires will allow them to absorb the strain of thermal shock with minimal stress. Furthermore, the interlaced nature of the wires provides containment of any segment that might become loose. We will discuss the progress on studies of analogue materials and fabrication techniques for sinuous target materials.

  18. Production Target Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dale, Gregory E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Olivas, Eric Richard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-07-28

    The Northstar 99Mo production target, a cylindrical length of 100Mo rod, has evolved considerably since its first conception.  The cylinder was very early sliced into disks to increase the heat transfer area, first to 1 mm thick disks then to the current 0.5 mm thick.  The coolant was changed early in the target development from water to helium to eliminate corrosion and dissolution.  The diameter has increased from initially 6 mm to 12 mm, the current diameter of the test target now at ANL, to nominally 28 mm (26-30.6 mm, depending upon optimal beam spot size and shape).  The length has also changed to improve the production to cost ratio, so now the target is nominally 41 mm long (excluding coolant gaps between disks), and irradiated on both ends.  This report summarizes the current status of the plant target design.

  19. Targeted assets risk analysis.

    Science.gov (United States)

    Bouwsema, Barry

    2013-01-01

    Risk assessments utilising the consolidated risk assessment process as described by Public Safety Canada and the Centre for Security Science utilise the five threat categories of natural, human accidental, technological, human intentional and chemical, biological, radiological, nuclear or explosive (CBRNE). The categories of human intentional and CBRNE indicate intended actions against specific targets. It is therefore necessary to be able to identify which pieces of critical infrastructure represent the likely targets of individuals with malicious intent. Using the consolidated risk assessment process and the target capabilities list, coupled with the CARVER methodology and a security vulnerability analysis, it is possible to identify these targeted assets and their weaknesses. This process can help emergency managers to identify where resources should be allocated and funding spent. Targeted Assets Risk Analysis (TARA) presents a new opportunity to improve how risk is measured, monitored, managed and minimised through the four phases of emergency management, namely, prevention, preparation, response and recovery. To reduce risk throughout Canada, Defence Research and Development Canada is interested in researching the potential benefits of a comprehensive approach to risk assessment and management. The TARA provides a framework against which potential human intentional threats can be measured and quantified, thereby improving safety for all Canadians.

  20. Heat flow diagrams with and without a deaerator for steam turbine plants with T-250/300-23.5 turbines

    Science.gov (United States)

    Valamin, A. E.; Kultyshev, A. Yu.; Shibaev, T. L.; Gol'dberg, A. A.; Stepanov, M. Yu.

    2016-11-01

    A T-250/300-240 turbine (currently known as T-250/300-23.5), which is operated at 31 steam turbine plants, is the largest in the world extraction turbine (by the heating extraction load) and one of the largest by the nominal capacity. All steam turbine plants equipped with T-250/300-23.5 turbines of different modifications are operated in large cities of Russia and the neighboring countries covering a significant part of the needs of cities for the electric power and almost fully supplying them with heat power. The design life of a significant part of the operated steam turbine plants of this family is either expired or almost expired. It refers to both the turbine unit (including a turbine and a generator) and the turbine plant equipment. For steam turbine plants equipped with T-250/300-23.5 turbines, which were initially designed and mounted for work with deaerators at electric power stations, the heat flow diagrams with and without a deaerator were compared. The main advantages and disadvantages of each scheme were shown. It was concluded that, for the newly constructed power units with supercritical steam parameters, it is preferable to use the heat flow diagram without a deaerator; for the upgraded blocks, if there are no objective reasons for the removal of a deaerator, it is recommended to keep the existing heat flow diagram of a turbine plant.

  1. 30 CFR 250.210 - If I conduct ancillary activities, what reporting and data/information retention requirements...

    Science.gov (United States)

    2010-07-01

    ... OPERATIONS IN THE OUTER CONTINENTAL SHELF Plans and Information Ancillary Activities § 250.210 If I conduct ancillary activities, what reporting and data/information retention requirements must I satisfy? (a... data or information obtained or derived from your ancillary activities. When applicable, MMS...

  2. 20 CFR 663.250 - How long must an individual participant be in intensive services to be eligible for training...

    Science.gov (United States)

    2010-04-01

    ... of time an individual spends in intensive services should be sufficient to prepare the individual for... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false How long must an individual participant be in... TITLE I OF THE WORKFORCE INVESTMENT ACT Intensive Services § 663.250 How long must an...

  3. Shiprock, AZ NM CO UT 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  4. Homocysteine-lowering effect of 500 ug folic acid every other day versus 250 ug/day

    NARCIS (Netherlands)

    Brouwer, I.A.; Rooij, van I.A.L.M.; Dusseldorp, van M.; Thomas, C.M.G.; Blom, H.J.; Hautvast, J.G.A.J.; Eskes, T.K.A.B.

    2000-01-01

    Elevated plasma total homocysteine (tHcy) concentrations are a risk factor for neural tube defects and vascular diseases. Supplementation with folic acid decreases tHcy. We investigated whether supplementation with 500 ?g folic acid every other day is as effective in lowering tHcy as 250 ?g folic ac

  5. Predicted Performance of a Dc Beam Driven Fem Oscillator Designed for Fusion Applications at 200-250 Ghz

    NARCIS (Netherlands)

    Caplan, M.; Best, R. W. B.; Verhoeven, A. G. A.; van der Wiel, M. J.; Urbanus, W. H.; Bratman, V. L.; Denisov, G. G.

    1993-01-01

    At the FOM Institute (The Netherlands) a free electron laser using a dc beam with depressed collector is being developed for plasma heating, which will be capable of producing 1 MW cw output over an adjustable tuning range of 200-250 GHz. The basic design parameters for the electron beam, undulator

  6. 30 CFR 250.1161 - When may I flare or vent gas for extended periods of time?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When may I flare or vent gas for extended... Production Requirements Flaring, Venting, and Burning Hydrocarbons § 250.1161 When may I flare or vent gas... flare or vent gas for an extended period of time. The Regional Supervisor will specify the...

  7. Evaluation of the Performance of Vortex Generators on the DU 91-W2-250 Profile using Stereoscopic PIV

    DEFF Research Database (Denmark)

    Velte, Clara Marika; Hansen, Martin Otto Laver; Meyer, Knud Erik

    2009-01-01

    Stereoscopic PIV measurements investigating the effect of Vortex Generators on the lift force near stall and on glide ratio at best aerodynamic performance have been carried out in the LM Glasfiber wind tunnel on a DU 91-W2-250 profile. Measurements at two Reynolds numbers were analyzed; Re=0...

  8. Evaluation of the Performance of Vortex Generators on the DU 91-W2-250 Profile using Stereoscopic PIV

    DEFF Research Database (Denmark)

    Velte, Clara Marika; Hansen, Martin Otto Laver; Meyer, Knud Erik

    2008-01-01

    Stereoscopic PIV measurements investigating the effect of Vortex Generators on the lift force near stall and on glide ratio at best aerodynamic performance have been carried out in the LM Glasfiber wind tunnel on a DU 91-W2-250 profile. Measurements at two Reynolds numbers were analyzed; Re=0...

  9. Dalhart, NM OK TX CO 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  10. Targeted Phototherapy (newer phototherapy

    Directory of Open Access Journals (Sweden)

    Zonunsanga

    2015-04-01

    Full Text Available Conventional phototherapy uses a whole body cabinet or body part machine such as hand, foot or scalp machines. They have many disadvantages due to which new phototherapy technique was then developed to overcome this situation. This new technique is called targeted phototherapy which includes excimer laser, intense pulse light system (IPL, photodynamic therapy and ultraviolet (UV light source with a sophisticated delivery system which is easy to be operated by hands. The mechanisms of action of targeted phototherapy systems are similar to those in conventional UVB/UVA therapy. They have many advantages like less chances of side effects, avoidance of exposure of unnecessary sites, faster response, shortening of the duration of treatments. But they have disadvantages like high costs and inability to use for extensive areas. This review article discusses targeted phototherapy in considerable to the mechanism of actions and advantages and disadvantages in comparison to the conventional phototherapy.

  11. Modelling Recycling Targets

    DEFF Research Database (Denmark)

    hill, amanda; Leinikka Dall, Ole; Andersen, Frits Møller

    2014-01-01

    Within the European Union (EU) a paradigm shift is currently occurring in the waste sector, where EU waste directives and national waste strategies are placing emphasis on resource efficiency and recycling targets. The most recent Danish resource strategy calculates a national recycling rate of 22......% for household waste, and sets an ambitious goal of a 50% recycling rate by 2020. This study integrates the recycling target into the FRIDA model to project how much waste and from which streams should be diverted from incineration to recycling in order to achieve the target. Furthermore, it discusses how...... the existing technological, organizational and legislative frameworks may affect recycling activities. The results of the analysis show that with current best practice recycling rates, the 50% recycling rate cannot be reached without recycling of household biowaste. It also shows that all Danish municipalities...

  12. Setting reference targets

    Energy Technology Data Exchange (ETDEWEB)

    Ruland, R.E.

    1997-04-01

    Reference Targets are used to represent virtual quantities like the magnetic axis of a magnet or the definition of a coordinate system. To explain the function of reference targets in the sequence of the alignment process, this paper will first briefly discuss the geometry of the trajectory design space and of the surveying space, then continue with an overview of a typical alignment process. This is followed by a discussion on magnet fiducialization. While the magnetic measurement methods to determine the magnetic centerline are only listed (they will be discussed in detail in a subsequent talk), emphasis is given to the optical/mechanical methods and to the task of transferring the centerline position to reference targets.

  13. Cooled particle accelerator target

    Science.gov (United States)

    Degtiarenko, Pavel V.

    2005-06-14

    A novel particle beam target comprising: a rotating target disc mounted on a retainer and thermally coupled to a first array of spaced-apart parallel plate fins that extend radially inwardly from the retainer and mesh without physical contact with a second array of spaced-apart parallel plate fins that extend radially outwardly from and are thermally coupled to a cooling mechanism capable of removing heat from said second array of spaced-apart fins and located within the first array of spaced-apart parallel fins. Radiant thermal exchange between the two arrays of parallel plate fins provides removal of heat from the rotating disc. A method of cooling the rotating target is also described.

  14. STUDY ON DISCHARGE HEAT UTILIZATION OF 250 MWe PCMSR TURBINE SYSTEM FOR DESALINATION USING MODIFIED MED

    Directory of Open Access Journals (Sweden)

    Andang Widiharto

    2015-03-01

    Full Text Available PCMSR (Passive Compact Molten Salt Reactor is one type of Advanced Nuclear Reactors. The PCMSR has benefit charasteristics of very efficient fuel use, high safety charecteristic as well as high thermodinamics efficiency. This is due to its breeding capability, inherently safe characteristic and totally passive safety system. The PCMSR design consists of three module, i.e. reactor module, turbine module and fuel management module. Analysis in performed by parametric calculation of the turbine system to calculate the turbine system efficiency and the hat available for desalination. After that the mass and energi balance of desalination process are calculated to calculate the amount of distillate produced and the amount of feed sea water needed. The turbine module is designed to be operated at maximum temperature cycle of 1373 K (1200 0C and minimum temperature cycle of 333 K (60 0K. The parametric calculation shows that the optimum turbine pressure ratio is 4.3 that gives the conversion efficiency of 56 % for 4 stages turbine and 4 stages compressor and equiped with recuperator. In this optimum condition, the 250 MWe PCMSR turbine system produces 196 MWth of waste heat with the temperature of cooling fluid in the range from 327 K (54 0C to 368 K (92 0C. This waste heat can be utilized for desalination. By using MMED desalination system, this waste heat can be used to produce fresh water (distillate from sea water feed. The amount of the destillate produced is 48663 ton per day by using 15 distillation effects. The performance ratio value is 2.8727 kg/MJ by using 15 distillation effects. Keywords: PCMSR, discharged heat, MMED desalination   PCMSR (Passive Compact Molten Salt Reactor merupakan salah satu tipe dari Reaktor Nuklir Maju. PCMSR memiliki keuntungan berupa penggunaan bahan bakar yang sangat efisisien, sifat keselamatan tinggi dan sekaligus efisiensi termodinamika yang tinggi. Hal ini disebabkan oleh kemampuan pembiakan bahan bakar, sifat

  15. Statistics and scaling of turbulence in a spatially developing mixing layer at Reλ = 250

    KAUST Repository

    Attili, Antonio

    2012-03-21

    The turbulent flow originating from the interaction between two parallel streams with different velocities is studied by means of direct numerical simulation. Rather than the more common temporal evolving layer, a spatially evolving configuration, with perturbed laminar inlet conditions is considered. The streamwise evolution and the self-similar state of turbulence statistics are reported and compared to results available in the literature. The characteristics of the transitional region agree with those observed in other simulations and experiments of mixing layers originating from laminar inlets. The present results indicate that the transitional region depends strongly on the inlet flow. Conversely, the self-similar state of turbulent kinetic energy and dissipation agrees quantitatively with those in a temporal mixing layer developing from turbulent initial conditions [M. M. Rogers and R. D. Moser, “Direct simulation of a self-similar turbulent mixing layer,” Phys. Fluids6, 903 (1994)]. The statistical features of turbulence in the self-similar region have been analysed in terms of longitudinal velocity structure functions, and scaling exponents are estimated by applying the extended self-similarity concept. In the small scale range (60 < r/η < 250), the scaling exponents display the universal anomalous scaling observed in homogeneous isotropic turbulence. The hypothesis of isotropy recovery holds in the turbulent mixing layer despite the presence of strong shear and large-scale structures, independently of the means of turbulence generation. At larger scales (r/η > 400), the mean shear and large coherent structures result in a significant deviation from predictions based on homogeneous isotropic turbulence theory. In this second scaling range, the numerical values of the exponents agree quantitatively with those reported for a variety of other flows characterized by strong shear, such as boundary layers, as well as channel and wake flows.

  16. Initial antihypertensive prescription and switching: a 5 year cohort study from 250,851 patients.

    Directory of Open Access Journals (Sweden)

    Martin C S Wong

    Full Text Available PURPOSE: Adverse effects of antihypertensive therapy incur substantial cost. We evaluated whether any major classes of antihypertensive drugs were significantly associated with switching as a proxy measure of medication side effects in a large Chinese population in Hong Kong. METHODS: From a clinical database, all adult patients newly prescribed an antihypertensive mono-therapy in Hong Kong between the years 2001-2003 and 2005 were included. Those who paid only one visit, died or stayed in the cohort for <180 days after the prescription, or prescribed more than one antihypertensive agent were excluded. The factors associated with switching at 180 days were evaluated by multivariate regression analyses. Age, gender, payment status, service type, district of residence, drug class, systolic and diastolic blood pressure levels were predictor variables. RESULTS: From 250,851 subjects, 159,813 patients were eligible. A total of 6,163 (3.9% switched their medications within 180 days. Patients prescribed thiazide diuretics had the highest switching rate (5.6%, followed by ACEIs (4.5%, CCBs (4.4% and beta-blockers (3.2%. When compared with ACEIs, patients on thiazide diuretics were significantly more likely to be switchers (adjusted odds ratio [AOR] 1.49, 95% C.I. 1.31-1.69, p<0.001, whilst patients prescribed CCBs and beta-blockers were similarly likely to have switching. Following these patients up for 5 years showed that thiazide had the most marked increase in switching rate. CONCLUSIONS: The higher rates of switching among thiazide diuretics in this study might raise a probably greater incidence of their adverse effects in this Chinese population, yet other factors might also influence switching rates. Patients prescribed thiazide diuretics for longer term should be observed for their intolerability.

  17. Aspectos generales de la Ley número 17.250 de relaciones de consumo

    Directory of Open Access Journals (Sweden)

    Teresita Mercader Pizzorno

    2014-11-01

    Full Text Available El 20 de setiembre de 1999 el Poder Ejecutivo de nuestro país promulgó una ley, la 17.189, por la que se establecían normas destinadas a regular las relaciones de consumo, la que fue publicada en el Diario Oficial del 30 de setiembre de 1999.Su último art., el 52, establecía que comenzaría a regir a los nueve meses contados desde su publicación. Por tanto, la fecha de entrada en vigencia fue ello. de julio del presente año.Sin embargo, un error acaecido en el proceso de elaboración determinó que, en forma prácticamente inmediata a su entrada en vigor, se procediera a elaborar un proyecto de ley para derogarla y sustituirla por otra, que fue promulgada el 11 de agosto de 2000 con el número 17.250 Y fue reglamentada por decreto 244/2000 del 23 de agosto del mismo año.El texto de la nueva leyes prácticamente igual al de la anterior, excepto, claro está, el artículo 33 que es el que había sido aprobado en el trámite de sanción en una y otra Cámara con distinto texto,También en la segunda ley se sustituyó el artículo 52 antes citado (...

  18. AA antiproton production target

    CERN Multimedia

    1979-01-01

    The first version of the antiproton production target was a tungsten rod, 11 cm long (actually a row of 11 rods, each 1 cm long) and 3 mm in diameter. The rod was embedded in graphite, pressure-seated into an outer casing made of stainless steel. The casing had fins for forced-air cooling. In this picture, the 26 GeV high-intensity beam from the PS enters from the right, where a scintillator screen, with circles every 5 mm in radius, permits precise aim at the target centre. See also 7903034 and 7905094.

  19. Targeting peroxiredoxins against leukemia.

    Science.gov (United States)

    Liu, Chuan-Xu; Zhou, Hu-Chen; Yin, Qian-Qian; Wu, Ying-Li; Chen, Guo-Qiang

    2013-01-15

    Peroxiredoxins (Prx), a family of small non-seleno peroxidases, are important regulators for cellular reactive oxygen species (ROS), which contribute to many signaling pathways and pathogenesis of diseases. Targeting redox homeostasis is being developed as a promising therapeutic strategy for many diseases such as cancers. This mini-review attempts to focus on our recent discoveries on adenanthin as the first natural molecule to specifically target the resolving cysteines of Prx I and Prx II and thus inhibit their peroxidase activities, and its role in differentiation induction in vitro and in vivo of acute myeloid leukemic cells.

  20. G250启动子的克隆及其在人肾癌细胞中的特异生物活性%Cloning of G250 gene promoter and its specific bioactivity in human renal cell carcinoma cells

    Institute of Scientific and Technical Information of China (English)

    薛松; 郑骏年; 温儒民; 郝林; 毛立军; 孔德领

    2008-01-01

    Objective To clone DNA sequence of G250 promoter and identify its transcriptional activities in human renal cell carcinoma cells. Methods Two fragments of G250 promoter were acquired by PCR amplification and inserted into lucifcrase reporter vectors (pGL3-basic) to reconstruct a recombi-nant plasmids named pGLB-G551 and pGLB-G218. Then the reconstructed plasmids were transiently trans-fected into human renal carcinoma cell line Kerr-3 cells and cervical cancer cell line Hela ceils. The tran-scriptional activities of G250 promoter in various ceils were determined by measuring the luciferase activi-ties after 48 h of transfection. A pGL3-Basic was used as negative control. Results Electrophoresis and DNA sequencing demonstrated that cloned G250 promoters were 551 bp and 218 bp, respectively, as regis-tered in Gen-Bank. The recombinant plasmids pGLB-G551 and pGLB-G218 were comfirmed by double di-gestion and DNA sequencing with correct results. Luciferase assay showed there were transcriptional activi-ties of pGLB-G551 and pGLB-G218 in the Ketr-3 ceils and Hela cells and the relative luciferase activities of pGLB-G551 and pGLB-G218 had no significant difference. Conclusion The G250 promoter cloned in this study is more highly activated in human renal cell carcinoma cells with G250 expression. This makes it a potential candidate promoter in the gene therapy of renal cell carcinoma.%目的 克隆G250启动子并插入pG3-Basic真核表达载体,探讨G250启动子在肾癌细胞中的特异生物活性.方法 提取宫颈癌Hela细胞总DNA作为模板,设计两对引物进行PCR,获取两段不同长度的G250启动子片段.测序后分别将获取的551 bp和218 bp启动子片段克隆到pGL3-Basic载体中,构建双荧光素酶检测质粒pGLB-G551和pGLB-G218.将pGL3-Basic、pGLB-G551、pGLB-G218各1μg转染G250阳性宫颈癌Hela细胞、肾癌Ketr-3细胞.运用双荧光素酶检测技术,确定G250启动子的转录活性.结果 电泳与测序结果

  1. Cancer immunotherapy targeting neoantigens.

    Science.gov (United States)

    Lu, Yong-Chen; Robbins, Paul F

    2016-02-01

    Neoantigens are antigens encoded by tumor-specific mutated genes. Studies in the past few years have suggested a key role for neoantigens in cancer immunotherapy. Here we review the discoveries of neoantigens in the past two decades and the current advances in neoantigen identification. We also discuss the potential benefits and obstacles to the development of effective cancer immunotherapies targeting neoantigens.

  2. Microenvironmental targets in sarcoma

    Directory of Open Access Journals (Sweden)

    Monika eEhnman

    2015-11-01

    Full Text Available Sarcomas are rare malignant tumors affecting all age groups. They are typically classified according to their resemblance to corresponding normal tissue. Their heterogeneous features, for example in terms of disease-driving genetic aberrations and body location, complicate both disease classification and development of novel treatment regimens. Many years of failure of improved patient outcome in clinical trials has lead to the conclusion that novel targeted therapies are likely needed in combination with current multimodality regimens. Sarcomas have not, in contrast to the common carcinomas, been the subject for larger systematic studies on how tumor behavior relates to characteristics of the tumor microenvironment. There is consequently an urgent need for identifying suitable molecular targets, not only in tumor cells, but also in the tumor microenvironment. This review discusses preclinical and clinical data about potential molecular targets in sarcomas. Studies on targeted therapies involving the tumor microenvironment are prioritized. A greater understanding of the biological context is expected to facilitate more successful design of future clinical trials in sarcoma.

  3. Major Targets for 2010

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ This year, the main targets we have set for economic and social development are: increasing GDP by approximately 8 percent, creating jobs for more than 9 million people, keeping the urban registered unemployment rate no higher than 4.6 percent, holding the rise in consumer prices to around 3 percent, and improving the balance of payments.

  4. Target chambers for gammashpere

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, M.P.; Falout, J.W.; Nardi, B.G. [and others

    1995-08-01

    One of our responsibilities for Gammasphere, was designing and constructing two target chambers and associated beamlines to be used with the spectrometer. The first chamber was used with the early implementation phase of Gammasphere, and consisted of two spun-Al hemispheres welded together giving a wall thickness of 0.063 inches and a diameter of 12 inches.

  5. ISOLDE back on target

    CERN Multimedia

    Anaïs Schaeffer

    2014-01-01

    Today, Friday 1 August, the ISOLDE installation, supplied by the beams of the PS Booster, restarted its physics programme. After a shutdown of almost a year and a half, there was a real buzz in the air as the first beam of protons hit the target of the first post-LS1 ISOLDE experiment.   One of the new target-handling robots installed by ISOLDE during LS1. Many improvements have been made to the ISOLDE installation during LS1. One of the main projects was the installation of new robots for handling the targets (see photo 1). “Our targets are bombarded by protons from the PS Booster’s beams and become very radioactive,” explains Maria Jose Garcia Borge, spokesperson for the ISOLDE collaboration. “They therefore need to be handled carefully, which is where the robots come in. The robots we had until now were already over 20 years old and were starting to suffer from the effects of radiation. So LS1 was a perfect opportunity to replace them with more moder...

  6. Targeted Therapy for Melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Quinn, Thomas [Alphamed, Jackson, TN (United States); Moore, Herbert [Alphamed, Jackson, TN (United States)

    2016-12-05

    The research project entitled,” Targeted Therapy for Melanoma,” was focused on investigating the use of kidney protection measures to lower the non-specific kidney uptake of the radiolabeled Pb-DOTA-ReCCMSH peptide. Previous published work demonstrated that the kidney exhibited the highest non-target tissue uptake of the 212Pb/203Pb radiolabeled melanoma targeting peptide DOTA-ReCCMSH. The radiolabeled alpha-melanocyte stimulating hormone (α-MSH) peptide analog DOTA-Re(Arg11)CCMSH, which binds the melanocortin-1 receptor over-expressed on melanoma tumor cells, has shown promise as a PRRT agent in pre-clinical studies. High tumor uptake of 212Pb labeled DOTA-Re(Arg11)CCMSH resulted in tumor reduction or eradication in melanoma therapy studies. Of particular note was the 20-50% cure rate observed when melanoma mice were treated with alpha particle emitter 212Pb. However, as with most PRRT agents, high radiation doses to the kidneys where observed. To optimize tumor treatment efficacy and reduce nephrotoxicity, the tumor to kidney uptake ratio must be improved. Strategies to reduce kidney retention of the radiolabeled peptide, while not effecting tumor uptake and retention, can be broken into several categories including modification of the targeting peptide sequence and reducing proximal tubule reabsorption.

  7. Production asymmetry of $\\Lambda^0$ and ${\\overline{\\Lambda}}^0$ in $\\pi^{\\pm}$, $K^{\\pm}$, p - nucleon collisions at 250 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Nicola, Marcello Santo [Brazilian Center for Physics Research, Rio de Janeiro (Brazil)

    2001-02-01

    Using data from Fermilab xed-target experiment E769, we have measured particleantiparticle production asymmetries for Λ0 hyperons in π± - nucleon interactions, K ± - nucleon interactions and p - nucleon interactions at 250 GeV/c. The asymmetries are measured as functions of Feynman-x (xf ) and pT2 over the ranges 0 ≤ pT2 ≤ 4(GeV/c)2 and -0.12 ≤ xF ≤ 0.12 (for positive beam) and 0 ≤ pT2 ≤ 10(GeV/c)2 and -0.16 ≤ xF ≤ 0:.0 for the negative beam. We find substantial asymmetries, even at xF = 0. We also observe leading-particle-type asymmetries which qualitatively agree with theoretical predictions.

  8. Biometric Calculation and Refractive Results. A Study of 250 Cases of Patients Operated for Cataract

    Directory of Open Access Journals (Sweden)

    Inés Benita Zamora Galindo

    2012-02-01

    Full Text Available Fundamento: el implante de lentes intraoculares en la cirugía de catarata significa un avance en la corrección refractiva de la afaquia. Pero sin el estudio previo a la cirugía y el correcto cálculo de la lente intraocular, los resultados no serían satisfactorios. Objetivo: evaluar el cálculo biométrico y la refracción posquirúrgica de pacientes operados de cataratas. Metodos: estudio descriptivo realizado en el Centro de Oftalmología del Estado de Anzoátegui, Venezuela, que incluyó 250 pacientes sometidos a cirugía de catarata, a quienes previamente se les realizó refracción, queratometría, biometría y cálculo de lente intraocular. Después de la cirugía se determinó: refracción esperada por el cálculo biométrico, error refractivo posoperatorio, agudeza visual posquirúrgica sin corrección y con corrección. Resultados: predominó el sexo femenino y el grupo de edad entre 60 y 69 años. El valor más registrado de la queratometría  osciló de 43 a 44 dioptrías. El valor de la longitud axial más destacado fue de 22 a 24 mm. Las lentes intraoculares más usadas fueron de 16 a 20 dioptrías y las de 21 a 25 dioptrías. El mayor por ciento de la refracción esperada estuvo en el grupo de 0,00 a 0, 50. El error refractivo que predominó fue el de 0,50 a 1,00. En la refracción realizada al mes de la cirugía, sin cristales, más de la mitad de los pacientes obtuvo visiones entre 20/30 y 20/25. Conclusiones: se demostró la efectividad del cálculo de la lente intraocular previo a la cirugía de catarata.

  9. Relationship between hepatic lipase promoter 250 G/A polymorphism and serum lipid concentration%肝脂酶启动子250 G/A多态性与血脂的关系

    Institute of Scientific and Technical Information of China (English)

    倪培华; 应雅韵; 张洁; 金磊

    2005-01-01

    目的探讨各项血脂水平与肝脂酶(HL)启动子250 G/A基因多态性的关系.方法运用聚合酶链反应-限制性内切酶片段长度多态性技术(PCR-RFLP),对112例三酰甘油(TG)正常者和103例高TG者的HL启动子250 G/A基因多态性进行研究.结果发现HL启动子250 AA等位基因频率在高TG组为0.447 7明显高于正常TG组(0.263 4,P<0.05).在总研究组发现AA型的TG、载脂蛋白B(ApoB)浓度明显高于GG型和GA型,而载脂蛋白Al(ApoAl)则明显降低(P<0.05).按性别分层后发现AA型女性和男性的TG、低密度脂蛋白胆固醇(LDL-C)的浓度明显高于非AA型同性(P<0.05),而高密度脂蛋白胆固醇(HDL-C)、ApoAl浓度分别低于非AA型的同性(P<0.05).经Logistic回归分析显示年龄、LDL-C、ApoB、AA型是危险因子,而HDL-C是保护因子.结论 HL启动子250 G/A多态性与高TG血症的发生相关,并可影响血浆脂类的代谢,可能是高TG所致疾病的危险因素.

  10. THE STUDY OF IMPROVING OF STABILITY AND RELIABILITY FOR 250kV HIGH VOLTAGE POWER%改进250kV高压电源稳定性与可靠性的研究

    Institute of Scientific and Technical Information of China (English)

    廖小东; 郑思孝; 刘仲阳; 孙官清; 王培录

    2001-01-01

    The hitches for a ppearing in the high voltage power at 250kV and improvement of the controlling circuit techniques are described. The static high voltage output was exercised by raising the high voltage gradually. The affects between the current load-variety and the vaviety of the input voltoge at + 1096 against the high voltage stability have been obtained. The experiments prove that the high voltage stability have been raised greatly via improving the controlling circuit.

  11. Pionic charge exchange on the proton from 40 to 250 MeV

    Science.gov (United States)

    Breitschopf, J.; Bauer, M.; Clement, H.; Cröni, M.; Denz, H.; Friedman, E.; Gibson, E. F.; Meier, R.; Wagner, G. J.

    2006-08-01

    The total cross sections for pionic charge exchange on hydrogen were measured using a transmission technique on thin CH2 and C targets. Data were taken for π- lab energies from 39 to 247 MeV with total errors of typically 2% over the Δ-resonance and up to 10% at the lowest energies. Deviations from the predictions of the SAID phase shift analysis in the 60-80 MeV region are interpreted as evidence for isospin-symmetry breaking in the s-wave amplitudes. The charge dependence of the Δ-resonance properties appears to be smaller than previously reported.

  12. Polarization discrimination between repeater false-target and radar target

    Institute of Scientific and Technical Information of China (English)

    SHI LongFei; WANG XueSong; XIAO ShunPing

    2009-01-01

    High fidelity repeater false-target badly affects a radar system's detecting, tracking, and data processing. It is an available approach of confronting false-target for radar that discriminates firstly and then eliminates. Whereas for the technique progress about the repeater false-target jam, it is more and more difficult to discriminate this jam in the time-domain, frequency-domain, or space-domain. The technique using polarization information to discriminate the target and false-target is discussed in this paper. With the difference that false-target signal vector's polarization ratio is fixed and target echo signal vector's polarization ratio is variational along with radar transmission signal's polarization, we transform the discrimination problem to beeline distinguish problem in the 2-dim complex space. The distributing characteristic expression of the false-target discrimination statistic is constructed, with which the discrimination ratio of false-target is analyzed. For the target case, the decomposed model of target scattering matrix and the concept of distinguish quantity are proposed. Then, the discrimination ratio of target can be forecasted according to target distinguish quantity. Thus, the performance of discrimination method has been analyzed integrally. The simulation results demonstrate the method in this paper is effective on the discrimination of target and false-target.

  13. Determination of Recrystallization Temperature of Reverted Austenite of C-250 Maraging Steel%C-250马氏体时效钢逆变奥氏体再结晶温度的测定

    Institute of Scientific and Technical Information of China (English)

    赵飞; 秦路平; 魏志坚; 张华

    2011-01-01

    Based on the theory of phase transformation and recrystallization accompanied with thermal effect and volume effect, the austenization temperature and reverted austenite recrystallization temperature of C-250 maraging steel was determined by DSC and dilatometer.The austenization temperature is As ≈ 647 ℃ and Af≈ 780 ℃, while the recrystallization temperature of reverted austenite is 923.1 ℃.%利用相变过程和逆变再结晶过程伴随着热效应体积效应的原理,采用热分析和热膨胀相结合的方法来测定C-250马氏体时效钢的奥氏体化温度和逆变奥氏体再结晶温度.结果显示,C-250马氏体时效钢的奥氏体化温度为A≈647℃,A≈780℃,逆变奥氏体再结晶温度为923.1℃.

  14. Gene Targeting in Neuroendocrinology.

    Science.gov (United States)

    Candlish, Michael; De Angelis, Roberto; Götz, Viktoria; Boehm, Ulrich

    2015-09-20

    Research in neuroendocrinology faces particular challenges due to the complex interactions between cells in the hypothalamus, in the pituitary gland and in peripheral tissues. Within the hypothalamus alone, attempting to target a specific neuronal cell type can be problematic due to the heterogeneous nature and level of cellular diversity of hypothalamic nuclei. Because of the inherent complexity of the reproductive axis, the use of animal models and in vivo experiments are often a prerequisite in reproductive neuroendocrinology. The advent of targeted genetic modifications, particularly in mice, has opened new avenues of neuroendocrine research. Within this review, we evaluate various mouse models used in reproductive neuroendocrinology and discuss the different approaches to generate genetically modified mice, along with their inherent advantages and disadvantages. We also discuss a variety of versatile genetic tools with a focus on their potential use in reproductive neuroendocrinology.

  15. Modelling Recycling Targets

    DEFF Research Database (Denmark)

    Hill, Amanda Louise; Leinikka Dall, Ole; Andersen, Frits M.

    2014-01-01

    the existing technological, organizational and legislative frameworks may affect recycling activities. The results of the analysis show that with current best practice recycling rates, the 50% recycling rate cannot be reached without recycling of household biowaste. It also shows that all Danish municipalities...... will need to make efforts to recover all recyclable fractions, and that the increased recycling efforts of only selected municipalities will not be sufficient to reach the target.......Within the European Union (EU) a paradigm shift is currently occurring in the waste sector, where EU waste directives and national waste strategies are placing emphasis on resource efficiency and recycling targets. The most recent Danish resource strategy calculates a national recycling rate of 22...

  16. Foucault on targets.

    Science.gov (United States)

    Lynch, John

    2004-01-01

    This paper seeks to gain an insight into the behavior of a large NHS trust, in its attempt to meet a 90 percent patient access target, in a week long national audit in March 2003. Why did individuals act in dramatically different ways to their norm over this period. The work of Michel Foucault is used to explore these issues. The discourses of power, knowledge, discipline and governmentality are identified as key foucaudian themes that offer an alternative interpretation of how individuals behave in their place of work. The importance of the historical context of discourse within the NHS cannot be underestimated in shaping the behavior of individuals and groups today. Power and knowledge permeate NHS organizations through disciplinary practices and dressage. Governmentality seeks to maintain the status quo through disciplinary processes such as national healthcare targets. The natural response of NHS organizations is therefore, to seek order and conformity rather than disorder and conflict.

  17. Recognizing occluded MSTAR targets

    Science.gov (United States)

    Bhanu, Bir; Jones, Grinnell, III

    2000-08-01

    This paper presents an approach for recognizing occluded vehicle targets in Synthetic Aperture Radar (SAR) images. Using quasi-invariant local features, SAR scattering center locations and magnitudes, a recognition algorithm is presented that successfully recognizes highly occluded versions of actual vehicles from the MSTAR public data. Extensive experimental results are presented to show the effect of occlusion on recognition performance in terms of Probability of Correct Identification, Receiver Operating Characteristic (ROC) curves and confusion matrices. The effect of occlusion on performance of this recognition algorithm is accurately predicted. Combined effects such as occlusion and measured positional noise, as well as occlusion and other observed extended operating conditions (e.g., articulation) are also addressed. Although excellent forced recognition results can be achieved at very high (70%) occlusion, practical limitations are found due to the similarity of unoccluded confuser vehicles to highly occluded targets.

  18. Targeting biodefense markets.

    Science.gov (United States)

    Olinger, Gene Garrard

    2009-10-01

    The "World Vaccine Congress 2009" held in Washington D.C. (April 20-23, 2009) sponsored several sessions focused on the vaccine market targeting biodefense. On day one of the congress, a panel discussion outlined the federal progress in medical countermeasure preparedness that included emerging infections, influenza, and biodefense focuses. The second day, a session focused on the biodefense vaccine market with both government and industry members discussing the opportunities and challenges associated with the budding market.

  19. Implementing Target Value Design.

    Science.gov (United States)

    Alves, Thais da C L; Lichtig, Will; Rybkowski, Zofia K

    2017-01-01

    An alternative to the traditional way of designing projects is the process of target value design (TVD), which takes different departure points to start the design process. The TVD process starts with the client defining an allowable cost that needs to be met by the design and construction teams. An expected cost in the TVD process is defined through multiple interactions between multiple stakeholders who define wishes and others who define ways of achieving these wishes. Finally, a target cost is defined based on the expected profit the design and construction teams are expecting to make. TVD follows a series of continuous improvement efforts aimed at reaching the desired goals for the project and its associated target value cost. The process takes advantage of rapid cycles of suggestions, analyses, and implementation that starts with the definition of value for the client. In the traditional design process, the goal is to identify user preferences and find solutions that meet the needs of the client's expressed preferences. In the lean design process, the goal is to educate users about their values and advocate for a better facility over the long run; this way owners can help contractors and designers to identify better solutions. This article aims to inform the healthcare community about tools and techniques commonly used during the TVD process and how they can be used to educate and support project participants in developing better solutions to meet their needs now as well as in the future.

  20. Follicular penetration and targeting.

    Science.gov (United States)

    Lademann, Jürgen; Otberg, Nina; Jacobi, Ute; Hoffman, Robert M; Blume-Peytavi, Ulrike

    2005-12-01

    In the past, intercellular penetration was assumed to be the most important penetration pathway of topically applied substances. First hints that follicular penetration needs to be taken into consideration were confirmed by recent investigations, presented during the workshop "Follicular Penetration and Targeting" at the 4th Intercontinental Meeting of Hair Research Societies", in Berlin 2004. Hair follicles represent an efficient reservoir for the penetration of topically applied substances with subsequent targeting of distinct cell populations, e.g., nestin-expressing follicular bulge cells. The volume of this reservoir can be determined by differential stripping technology. The follicular penetration processes are significantly influenced by the state of the follicular infundibulum; recent experimental investigations could demonstrate that it is essential to distinguish between open and closed hair follicles. Topically applied substances can only penetrate into open hair follicle. Knowledge of follicular penetration is of high clinical relevance for functional targeting of distinct follicular regions. Human hair follicles show a hair-cycle-dependent variation of the dense neuronal and vascular network. Moreover, during hair follicle cycling with initiation of anagen, newly formed vessels occur. Thus, the potential of nestin-expressing hair follicle stem cells to form neurons and blood vessels was investigated.

  1. Two-color infrared FEL facility employing a 250-MeV linac injector of Saga synchrotron light source

    CERN Document Server

    Tomimasu, T; Koga, N; Hashiguchi, Y; Ochiai, Y; Ishibashi, M

    2001-01-01

    A two-color infrared free electron laser (FEL) facility is proposed. This FEL facility will employ a new 250-MeV linac injector of the Saga synchrotron light source (SLS). The linac has two operation modes: short macropulse mode of 1 mu s at 250 MeV is for injection to a 1.4-GeV storage ring and long macropulse mode of 13 mu s at 40 MeV is for the two-color FEL facility. The two-color FEL uses a single electron beam and simultaneously provides both infrared (IR) and far-IR laser pulses for pump-probe studies of quantum-well structures and studying vibrational relaxation of molecules. The Saga SLS will be operated in 2004 to promote material science, bio-medical and industrial applications in Kyushu.

  2. 250 kV 6 mA compact Cockcroft-Walton high-voltage power supply.

    Science.gov (United States)

    Ma, Zhan-Wen; Su, Xiao-Dong; Lu, Xiao-Long; Wei, Zhen; Wang, Jun-Run; Huang, Zhi-Wu; Miao, Tian-You; Su, Tong-Ling; Yao, Ze-En

    2016-08-01

    A compact power supply system for a compact neutron generator has been developed. A 4-stage symmetrical Cockcroft-Walton circuit is adopted to produce 250 kV direct current high-voltage. A 2-stage 280 kV isolation transformer system is used to drive the ion source power supply. For a compact structure, safety, and reliability during the operation, the Cockcroft-Walton circuit and the isolation transformer system are enclosed in an epoxy vessel containing the transformer oil whose size is about ∅350 mm × 766 mm. Test results indicate that the maximum output voltage of the power supply is 282 kV, and the stability of the output voltage is better than 0.63% when the high voltage power supply is operated at 250 kV, 6.9 mA with the input voltage varying ±10%.

  3. Antigenic differentiation of classical swine fever vaccinal strain PAV-250 from other strains, including field strains from Mexico.

    Science.gov (United States)

    Mendoza, Susana; Correa-Giron, Pablo; Aguilera, Edgar; Colmenares, Germán; Torres, Oscar; Cruz, Tonatiuh; Romero, Andres; Hernandez-Baumgarten, Eliseo; Ciprián, Abel

    2007-10-10

    Twenty-nine classical swine fever virus (CSFv) strains were grown in the PK15 or SK6 cell lines. Antigenic differentiation studies were performed using monoclonal antibodies (McAbs), produced at Lelystad (CDI-DLO), The Netherlands. The monoclonals which were classified numerically as monoclonals 2-13. Epitope map patterns that resulted from the reactivity with McAbs were found to be unrelated to the pathogenicity of the viruses studied. Antigenic determinants were recognized by McAbs 5 and 8, were not detected in some Mexican strains; however, sites for McAb 6 were absent in all strains. The PAV-250 vaccine strain was recognized by all MAbs, except by MAb 6. Furthermore, the Chinese C-S vaccine strain was found to be very similar to the GPE(-) vaccine. None of the studied Mexican vaccines or field strains was found to be similar to the PAV-250 vaccine strain.

  4. 250 kV 6 mA compact Cockcroft-Walton high-voltage power supply

    Science.gov (United States)

    Ma, Zhan-Wen; Su, Xiao-Dong; Lu, Xiao-Long; Wei, Zhen; Wang, Jun-Run; Huang, Zhi-Wu; Miao, Tian-You; Su, Tong-Ling; Yao, Ze-En

    2016-08-01

    A compact power supply system for a compact neutron generator has been developed. A 4-stage symmetrical Cockcroft-Walton circuit is adopted to produce 250 kV direct current high-voltage. A 2-stage 280 kV isolation transformer system is used to drive the ion source power supply. For a compact structure, safety, and reliability during the operation, the Cockcroft-Walton circuit and the isolation transformer system are enclosed in an epoxy vessel containing the transformer oil whose size is about ∅350 mm × 766 mm. Test results indicate that the maximum output voltage of the power supply is 282 kV, and the stability of the output voltage is better than 0.63% when the high voltage power supply is operated at 250 kV, 6.9 mA with the input voltage varying ±10%.

  5. Varaždin Borl Jeruzalem Tour On the occasion of the 250th anniversary of the Vienna meridian survey

    Directory of Open Access Journals (Sweden)

    Miljenko Lapaine

    2012-06-01

    Full Text Available On Saturday, June 9, 2012, the Croatian Cartographic Society organized a tour and a visit to the oldest trigonometric point in Croatia on the occasion of the 250th anniversary of the Vienna meridian arc survey. The tour was included in the Program of Professional Improvement of the Croatian Chamber of Chartered Engineers of Geodesy, and the Committee for Permanent Professional Improvement decided to award 5 (five points a person.

  6. Experimental '' of As at 170, 200, 250 and 300 K from the Bijvoet pairs of GaAs

    Indian Academy of Sciences (India)

    G Raja Sudha; K Vimala Devi; D Arthi; S Prasanna Subramanian; N Srinivasan; R Saravanan

    2002-08-01

    Anomalous dispersion effects lead to the modification of the measured X-ray structure factors. In this work, we have determined the imaginary part of the anomalous dispersion correction terms ('' ) of arsenide atom (As), through the X-ray data collected using spherical single crystal of GaAs, at various temperatures, i.e. 170, 200, 250 and 300 K. It is stressed that more measurements of '' of the elements are needed to confirm the theoretical calculations.

  7. Collective flow in central Au-Au collisions at 150, 250 and 400 A MeV

    CERN Document Server

    Németh, J; Nemeth, Judit; Papp, Gabor

    1999-01-01

    Spherical collective flow and thermalization are studied in gold on gold collisions at 150, 250 and 400 A MeV bombarding energies with a relativistically covariant formulation of a QMD code. We find that spherical flow and thermal energies calculated for all the charged fragments agree reasonably with the experimental values. The experimental cut at small angles used in the FOPI experiments at higher energies selects mainly the thermalized particles.

  8. Complete Set of Deuteron Analyzing Powers for dp Elastic Scattering at 250 MeV/nucleon and Three Nucleon Forces

    Directory of Open Access Journals (Sweden)

    Shimizu Y.

    2010-04-01

    Full Text Available Measurements of a complete set of deuteron analyzing powers (iT11, T20, T21, T22 for elastic deuteron–proton scattering at 250 MeV/nucleon have been performed with polarized deuteron beams at RIKEN RI Beam Factory. The obtained data are compared with the Faddeev calculations based on the modern nucleon–nucleon forces together with the Tucson-Melbourne’99, and UrbanaIX three nucleon forces.

  9. The Javalambre Survey Telescope (JST/T250): a multi-filter surveying machine for the Northern hemisphere

    Science.gov (United States)

    Cenarro, Javier; Marin-Franch, Antonio; Moles, Mariano; Cristobal-Hornillos, David; Dupke, Renato a.; Benitez, Txitxo; Taylor, Keith

    2015-08-01

    The Javalambre Survey Telescope (JST/T250) is a 2.55m Richey-Chretien, alt-azimuthal telescope with a field of view of diameter 3 deg and an effective etendue of 26.5 m2deg2 operated by the Centro de Estudios de Física del Cosmos de Aragón (CEFCA) at the Observatorio Astrofísico de Javalambre (OAJ). JST/T250 is particularly conceived and defined for carrying out large sky multi-filter surveys, like J-PAS (http://j-pas.org), which will be the main survey to be conducted during the first years of operation. To guarantee a seeing limited image quality all over the ~0.5m diameter focal plane, JST/T250 hosts state-of-the-arte optics, including complex hyperbolic M1 and M2 mirrors and a challenging field corrector of three lenses with 4 aspherical surfaces and high slopes. The optical configuration ends up with the powered entrance window of JPCam, the panoramic camera for J-PAS, with ~1200Mpix in a mosaic of 14 large format CCDs of 9.2k x 9.2k, and a set of 56 narrow-band, contiguous, optical filters. In this poster we present a detailed view of the telescope configuration, its optical performance and the expected operation for the J-PAS survey execution.

  10. 30 CFR 250.251 - If I propose activities in the Alaska OCS Region, what planning information must accompany the DPP?

    Science.gov (United States)

    2010-07-01

    ... activities in the Alaska OCS Region, the following planning information must accompany your DPP: (a... 30 Mineral Resources 2 2010-07-01 2010-07-01 false If I propose activities in the Alaska OCS Region, what planning information must accompany the DPP? 250.251 Section 250.251 Mineral...

  11. 12 CFR 250.220 - Whether member bank acting as trustee is prohibited by section 20 of the Banking Act of 1933 from...

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Whether member bank acting as trustee is prohibited by section 20 of the Banking Act of 1933 from acquiring majority of shares of mutual fund. 250.220 Section 250.220 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE...

  12. 12 CFR 250.408 - Short-term negotiable notes of banks not securities under section 32, Banking Act of 1933.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Short-term negotiable notes of banks not securities under section 32, Banking Act of 1933. 250.408 Section 250.408 Banks and Banking FEDERAL RESERVE... securities under section 32, Banking Act of 1933. (a) The Board of Governors has been asked whether...

  13. MODIS/TERRA MOD44W Land Water Mask Derived from MODIS and SRTM L3 Global 250m SIN Grid

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Land Water Mask Derived from MODIS and SRTM L3 Global 250m SIN Grid MOD44W The new MODIS 250 m land-water mask (Short Name: MOD44W) is an improvement over the...

  14. Optimization of radioimmunotherapy of renal cell carcinoma: labeling of monoclonal antibody cG250 with 131I, 90Y, 177Lu, or 186Re.

    NARCIS (Netherlands)

    Brouwers, A.H.; Eerd-Vismale, J.E.M. van; Frielink, C.; Oosterwijk, E.; Oyen, W.J.G.; Corstens, F.H.M.; Boerman, O.C.

    2004-01-01

    Radioimmunotherapy (RIT) can be performed with various radionuclides. We tested the stability, biodistribution, and therapeutic efficacy of various radioimmunoconjugates ((131)I, (88/90)Y, (177)Lu, and (186)Re) of chimeric antirenal cell cancer monoclonal antibody G250 (mAb cG250) in nude mice with

  15. 40 CFR Appendix F to Part 122 - Incorporated Places With Populations Greater Than 250,000 According to the 1990 Decennial Census...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Incorporated Places With Populations Greater Than 250,000 According to the 1990 Decennial Census by the Bureau of the Census F Appendix F to... Part 122—Incorporated Places With Populations Greater Than 250,000 According to the 1990...

  16. 30 CFR 250.465 - When must I submit an Application for Permit to Modify (APM) or an End of Operations Report to MMS?

    Science.gov (United States)

    2010-07-01

    ... MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Modify and Well Records § 250.465... of § 250.412. (3) Move a drilling unit from a wellbore before completing a well Submit forms...

  17. Targeted therapy for sarcomas

    Directory of Open Access Journals (Sweden)

    Forscher C

    2014-03-01

    Full Text Available Charles Forscher,1 Monica Mita,2 Robert Figlin3 1Sarcoma Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; 2Experimental Therapeutics Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; 3Academic Development Program, Samuel Oschin Comprehensive Cancer Institute, and Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA Abstract: Sarcomas are tumors of mesenchymal origin that make up approximately 1% of human cancers. They may arise as primary tumors in either bone or soft tissue, with approximately 11,280 soft tissue tumors and 2,650 bone tumors diagnosed each year in the United States. There are at least 50 different subtypes of soft tissue sarcoma, with new ones described with ever-increasing frequency. One way to look at sarcomas is to divide them into categories on the basis of their genetic make-up. One group of sarcomas has an identifiable, relatively simple genetic signature, such as the X:18 translocation seen in synovial sarcoma or the 11:22 translocation seen in Ewing's sarcoma. These specific abnormalities often lead to the presence of fusion proteins, such as EWS-FLI1 in Ewing's sarcoma, which are helpful as diagnostic tools and may become therapeutic targets in the future. Another group of sarcomas is characterized by complex genetic abnormalities as seen in leiomyosarcoma, osteosarcoma, and undifferentiated sarcoma. It is important to keep these distinctions in mind when contemplating the development of targeted agents for sarcomas. Different abnormalities in sarcoma could be divided by tumor subtype or by the molecular or pathway abnormality. However, some existing drugs or drugs in development may interfere with or alter more than one of the presented pathways. Keywords: sarcoma, targeted agents, tyrosine kinase inhibitors, mTor inhibition

  18. Targeting Prostate Cancer Metastasis

    Science.gov (United States)

    2015-09-01

    AWARD NUMBER: W81XWH-14-1-0412 TITLE: "Targeting Prostate Cancer Metastasis " PRINCIPAL INVESTIGATOR: Yong Teng CONTRACTING ORGANIZATION: REPORT...ng Prost a t e Cancer Metastasi s Sb. GRANT NUMBER W81XWH- 14- 1- 0 41 2 Sc. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Sd. PROJECT NUMBER YongTeng Se...r egulator in contr olling metastasis of p r ost a t e cancer and i nhi b i t i ng i t prevent s met ast asis . There are no drugs available to tar

  19. Should the dose of tenofovir be reduced to 200–250 mg/day, when combined with protease inhibitors?

    Directory of Open Access Journals (Sweden)

    Andrew Hill

    2014-11-01

    Full Text Available Introduction: The approved dose of tenofovir disproxil fumarate, 300 mg once daily, was established in clinical trials in combination with efavirenz, which does not significantly affect tenofovir concentrations. Combining tenofovir with lopinavir/r, darunavir/r or atazanavir/r increases tenofovir concentrations, which could raise the risk of renal adverse events. Newly approved tenofovir tablets are available at lower strength (200 or 250 mg for use in paediatrics. Methods: A literature search was used to assess the effects of lopinavir/r, darunavir/r and atazanavir/r on tenofovir plasma Cmax, AUC and Cmin (Geometric Mean Ratio and 90% confidence intervals. Assuming linear dose-proportional pharmacokinetics (as observed in dose-ranging studies, the 250 mg tablet was predicted to achieve plasma concentrations 17% lower than the 300 mg dose, and the 200 mg tablet to achieve plasma levels 33% lower. Effects on tenofovir plasma Cmax, AUC and Cmin concentrations were assessed for combined dosing of each protease inhibitor with 250 or 200 mg daily doses of tenofovir, versus standard dose tenofovir (300 mg daily without protease inhibitors. Results: In drug-drug interaction studies, lopinavir/ritonavir significantly increased tenofovir Cmax, AUC and Cmin. Effects of each PI on tenofovir Cmin were greater than effects on Cmax or AUC. Using a 250 mg paediatric dose of tenofovir with lopinavir/ritonavir, tenofovir Cmin was predicted to remain higher than tenofovir 300 mg used with efavirenz (GMR=1.26, 95% CI 1.14–1.38. Similar results were observed for use of tenofovir 250 mg with atazanavir/ritonavir (GMR=1.07, 95% CI 1.01–1.13 and with darunavir/ritonavir (GMR=1.14, 95% CI 0.99–1.31. Predicted tenofovir AUC levels for the 250 mg dose with protease inhibitors were all within the bioequivalence range, relative to use with efavirenz. Using a 200 mg paediatric dose of tenofovir with lopinavir/ritonavir, the tenofovir Cmin was predicted to be

  20. Open Targets: a platform for therapeutic target identification and validation

    Science.gov (United States)

    Koscielny, Gautier; An, Peter; Carvalho-Silva, Denise; Cham, Jennifer A.; Fumis, Luca; Gasparyan, Rippa; Hasan, Samiul; Karamanis, Nikiforos; Maguire, Michael; Papa, Eliseo; Pierleoni, Andrea; Pignatelli, Miguel; Platt, Theo; Rowland, Francis; Wankar, Priyanka; Bento, A. Patrícia; Burdett, Tony; Fabregat, Antonio; Forbes, Simon; Gaulton, Anna; Gonzalez, Cristina Yenyxe; Hermjakob, Henning; Hersey, Anne; Jupe, Steven; Kafkas, Şenay; Keays, Maria; Leroy, Catherine; Lopez, Francisco-Javier; Magarinos, Maria Paula; Malone, James; McEntyre, Johanna; Munoz-Pomer Fuentes, Alfonso; O'Donovan, Claire; Papatheodorou, Irene; Parkinson, Helen; Palka, Barbara; Paschall, Justin; Petryszak, Robert; Pratanwanich, Naruemon; Sarntivijal, Sirarat; Saunders, Gary; Sidiropoulos, Konstantinos; Smith, Thomas; Sondka, Zbyslaw; Stegle, Oliver; Tang, Y. Amy; Turner, Edward; Vaughan, Brendan; Vrousgou, Olga; Watkins, Xavier; Martin, Maria-Jesus; Sanseau, Philippe; Vamathevan, Jessica; Birney, Ewan; Barrett, Jeffrey; Dunham, Ian

    2017-01-01

    We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The platform provides either a target-centric workflow to identify diseases that may be associated with a specific target, or a disease-centric workflow to identify targets that may be associated with a specific disease. Users can easily transition between these target- and disease-centric workflows. The Open Targets Validation Platform is accessible at https://www.targetvalidation.org. PMID:27899665

  1. Low intensity beam target unit

    CERN Multimedia

    1976-01-01

    This is a wheel fitted with many targets around its periphery (each with three longitudinally arranged thin rods) of which one is placed into the beam via a rotation of the wheel. Upstream of each target is placed a luminescent screen, aligbed on each target axis and viewed with a TV camera, to make sure that one is hitting the target. This target unit was probably used to study target's behaviour (like beam heating). Gualtiero Del Torre stands on the left, Pierre Gerdil on the right.

  2. Targeting adipose tissue

    Directory of Open Access Journals (Sweden)

    Haas Bodo

    2012-10-01

    Full Text Available Abstract Two different types of adipose tissues can be found in humans enabling them to respond to starvation and cold: white adipose tissue (WAT is generally known and stores excess energy in the form of triacylglycerol (TG, insulates against cold, and serves as a mechanical cushion. Brown adipose tissue (BAT helps newborns to cope with cold. BAT has the capacity to uncouple the mitochondrial respiratory chain, thereby generating heat rather than adenosine triphosphate (ATP. The previously widely held view was that BAT disappears rapidly after birth and is no longer present in adult humans. Using positron emission tomography (PET, however, it was recently shown that metabolically active BAT occurs in defined regions and scattered in WAT of the adult and possibly has an influence on whole-body energy homeostasis. In obese individuals adipose tissue is at the center of metabolic syndrome. Targeting of WAT by thiazolidinediones (TZDs, activators of peroxisome proliferator-activated receptor γ (PPARγ a ‘master’ regulator of fat cell biology, is a current therapy for the treatment of type 2 diabetes. Since its unique capacity to increase energy consumption of the body and to dissipate surplus energy as heat, BAT offers new perspectives as a therapeutic target for the treatment of obesity and associated diseases such as type 2 diabetes and metabolic syndrome. Recent discoveries of new signaling pathways of BAT development give rise to new therapeutic possibilities in order to influence BAT content and activity.

  3. Target Housing Material Options

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-02-11

    With gas cooling, heat transfer coefficients are low compared to water. The benefit of gas from a heat transfer point of view is that there is really no upper temperature limit for the coolant, as compared to water, which is limited ultimately by the critical point, and in practice the critical heat flux. In our case with parallel flow channels, water is limited to even lower operating limits by nucleate boiling. So gas can get as hot as the containment material will allow, but to get the density and heat transfer up to something reasonable, we must also increase pressure, thus increasing stress on the containment, namely the front and back faces. We are designing to ASME BPVC, which, for most materials allows a maximum stress of UTS/3. So we want the highest possible UTS. For reference, the front face stress in the 12 mm target at 300 psi was about 90 MPa. The inconel 718 allowable stress at 900°C is 1/3 of 517 or 172 MPa. So we are in a very safe place, but the uTS is dropping rapidly with temperature above 900°C. As we increase target diameter, the challenge will be to keep the stress down. We are probably looking at keeping the allowable at or above the present value, and at as high a temperature as possible.

  4. Targeted therapy in melanoma.

    Science.gov (United States)

    Kudchadkar, Ragini R; Smalley, Keiran S M; Glass, L Frank; Trimble, James S; Sondak, Vernon K

    2013-01-01

    Since the discovery of activating mutations in the BRAF oncogene in melanoma, there has been remarkable progress in the development of targeted therapies for unresectable and metastatic melanoma. We review the latest developments in our understanding of the role of BRAF/MEK/ERK pathway signaling in melanoma, and the development of inhibitors of this pathway. We also explore alternative mutations seen in melanoma, such as NRAS, KIT, GNAQ, and GNA11, and the drug development that is ongoing based on this biology. Strategies for the management of the vexing clinical problem of BRAF inhibitor resistance, primarily via combination therapy, are outlined. With the recent approval of the BRAF inhibitor vemurafenib for stage IV metastatic melanoma, use of this agent is expanding in the United States. Thus, management of the skin toxicities of this agent, such as squamous cell carcinomas, "acneiform" eruptions, hand-foot syndrome, and panniculitis, will be a growing problem facing dermatologists today. We discuss the toxicities of targeted agents in use for melanoma, in particular the dermatologic effects and the management of these skin toxicities.

  5. 250 MP a超高压磨料射流井下内切割技术∗%Downhole Inner Cutting Technology Based on 250 MPa Ultra High Pressure Abrasive Water Jet

    Institute of Scientific and Technical Information of China (English)

    马认琦; 李刚; 王超; 鞠少栋; 刘占鏖; 徐鸿飞

    2015-01-01

    The decommission of offshore oil and gas production facilities is in demand of high efficient, safe and environmentally friendly cutting technology and equipment�High pressure abrasive water jet cutting technology have obvious advantages on offshore well abandonment�The status of the application and development of domestic and foreign abrasive water jet cutting technology in offshore oil and gas production facilities decommission are de⁃scribed�Comparative analyses are conducted on the domestic and foreign downhole abrasive water jet cutting equip⁃ment and performance parameters�The core technologies and equipment of the existing domestic low pressure and 250 MPa ultra⁃high pressure abrasive water jet downhole inner cutting technology are introduced�Field application results showed that the low⁃pressure and 250 MPa ultra⁃high pressure abrasive water jet inner cutting technology and equipment could meet the operation requirements.%海上油气生产设施弃置需要配置高效、安全环保的切割处理技术及设备,高压磨料射流井下切割技术用于海上弃井作业优势明显。阐述了国内外磨料射流切割技术在海洋油气生产设施弃置领域的应用与发展现状,对比分析了国内外磨料射流井下切割设备及其性能参数,介绍了国内现有低压与250 MP a超高压磨料射流井下内切割核心技术及配套设备。现场应用结果表明,低压与超高压250 MP a磨料射流井下内切割技术及设备满足作业要求。

  6. Technical Remodeling to the Subordinate System of Schwing BP250HDE-15 Concrete Pump%施维英BP250HDE-15型混凝土输送泵辅助系统技术改造

    Institute of Scientific and Technical Information of China (English)

    吴光锦

    2006-01-01

    文章通过对施维英BP250HDE-15型混凝土输送泵辅助系统利用大功率电机带动小齿轮油泵容易损坏部件、修理成本高、不利于维修等几方面问题的阐述,并通过理论验算进行了验证,说明技术改造方法具有可行性、经济性等优点.

  7. A Note on Inflation Targeting.

    Science.gov (United States)

    Lai, Ching-chong; Chang, Juin-jen

    2001-01-01

    Presents a pedagogical graphical exposition to illustrate the stabilizing effect of price target zones. Finds that authorities' commitment to defend a price target zone affects the public's inflation expectations and, in turn, reduces actual inflation. (RLH)

  8. Bradycardia During Targeted Temperature Management

    DEFF Research Database (Denmark)

    Thomsen, Jakob Hartvig; Nielsen, Niklas; Hassager, Christian

    2016-01-01

    OBJECTIVES: Bradycardia is common during targeted temperature management, likely being a physiologic response to lower body temperature, and has recently been associated with favorable outcome following out-of-hospital cardiac arrest in smaller observational studies. The present study sought...... to confirm this finding in a large multicenter cohort of patients treated with targeted temperature management at 33°C and explore the response to targeted temperature management targeting 36°C. DESIGN: Post hoc analysis of a prospective randomized study. SETTING: Thirty-six ICUs in 10 countries. PATIENTS......: We studied 447 (targeted temperature management = 33°C) and 430 (targeted temperature management = 36°C) comatose out-of-hospital cardiac arrest patients with available heart rate data, randomly assigned in the targeted temperature management trial from 2010 to 2013. INTERVENTIONS: Targeted...

  9. Scaling of exploding pusher targets

    Energy Technology Data Exchange (ETDEWEB)

    Nuckolls, J.H.

    1977-08-22

    A theory of exploding pusher laser pusher targets is compared to results of LASNEX calculations and to Livermore experiments. A scaling relationship is described which predicts the optimum target/pulse combinations as a function of the laser power.

  10. ORION laser target diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Bentley, C. D.; Edwards, R. D.; Andrew, J. E.; James, S. F.; Gardner, M. D.; Comley, A. J.; Vaughan, K.; Horsfield, C. J.; Rubery, M. S.; Rothman, S. D.; Daykin, S.; Masoero, S. J.; Palmer, J. B.; Meadowcroft, A. L.; Williams, B. M.; Gumbrell, E. T.; Fyrth, J. D.; Brown, C. R. D.; Hill, M. P.; Oades, K. [Plasma Physics Department, Atomic Weapons Establishment, Aldermaston, Reading, Berkshire RG7 4PR (United Kingdom); and others

    2012-10-15

    The ORION laser facility is one of the UK's premier laser facilities which became operational at AWE in 2010. Its primary mission is one of stockpile stewardship, ORION will extend the UK's experimental plasma physics capability to the high temperature, high density regime relevant to Atomic Weapons Establishment's (AWE) program. The ORION laser combines ten laser beams operating in the ns regime with two sub ps short pulse chirped pulse amplification beams. This gives the UK a unique combined long pulse/short pulse laser capability which is not only available to AWE personnel but also gives access to our international partners and visiting UK academia. The ORION laser facility is equipped with a comprehensive suite of some 45 diagnostics covering optical, particle, and x-ray diagnostics all able to image the laser target interaction point. This paper focuses on a small selection of these diagnostics.

  11. [Targeted therapies for melanoma].

    Science.gov (United States)

    Leiter, U; Meier, F; Garbe, C

    2014-07-01

    Since the discovery of activating mutations in the BRAF oncogene and also stimulation of immune mediated antitumor response in melanoma, there has been remarkable progress in the development of targeted therapies for unresectable and metastatic melanoma. This article addresses the latest developments of BRAF/MEK/ERK pathway signaling. In addition, the development of drugs to attack alternative mutations in melanoma, such as NRAS and KIT is described. Strategies for the management of BRAF inhibitor resistance, such as with combination therapy, are outlined. Antitumor immune therapies with monoclonal antibodies such as ipilimumab which acts by promoting T-cell activation or antibody blockade of programmed death-1 (PD-1) led to a long term response in metastatic melanoma. Results of latest clinical studies including the toxicity profile are described. Due to selective kinase inhibitors and immune checkpoint blockade, the therapy of unresectable metastatic melanoma has greatly improved and long-term survival of patients with metastatic melanoma seems a real possibility.

  12. ORION laser target diagnostics.

    Science.gov (United States)

    Bentley, C D; Edwards, R D; Andrew, J E; James, S F; Gardner, M D; Comley, A J; Vaughan, K; Horsfield, C J; Rubery, M S; Rothman, S D; Daykin, S; Masoero, S J; Palmer, J B; Meadowcroft, A L; Williams, B M; Gumbrell, E T; Fyrth, J D; Brown, C R D; Hill, M P; Oades, K; Wright, M J; Hood, B A; Kemshall, P

    2012-10-01

    The ORION laser facility is one of the UK's premier laser facilities which became operational at AWE in 2010. Its primary mission is one of stockpile stewardship, ORION will extend the UK's experimental plasma physics capability to the high temperature, high density regime relevant to Atomic Weapons Establishment's (AWE) program. The ORION laser combines ten laser beams operating in the ns regime with two sub ps short pulse chirped pulse amplification beams. This gives the UK a unique combined long pulse/short pulse laser capability which is not only available to AWE personnel but also gives access to our international partners and visiting UK academia. The ORION laser facility is equipped with a comprehensive suite of some 45 diagnostics covering optical, particle, and x-ray diagnostics all able to image the laser target interaction point. This paper focuses on a small selection of these diagnostics.

  13. Targeting of Antibodies using Aptamers

    OpenAIRE

    2003-01-01

    The chapter presents a methodology for the rapid selection of aptamers against antibody targets. It is a detailed account of the various methodological steps that describe the selection of aptamers, including PCR steps, buffers to be used, target immobilisation, partitioning and amplification of aptamers, clonning and sequencing, to results in high affinity and specificity ligands for the chosen target antibody.

  14. Serendipitous detection of an overdensity of Herschel-SPIRE 250 μm sources south of MRC 1138-26

    Science.gov (United States)

    Valtchanov, Ivan; Altieri, B.; Berta, S.; Chapin, E.; Coia, D.; Conversi, L.; Dannerbauer, H.; Domínguez-Sánchez, H.; Rawle, T. D.; Sánchez-Portal, M.; Santos, J. S.; Temporin, S.

    2013-12-01

    We report the serendipitous detection of a significant overdensity of Herschel-Spectral and Photometric Imaging Receiver 250 μm sources in the vicinity of MRC 1138-26. We use an adaptive kernel density estimate to quantify the significance, including a comparison with other fields. The overdensity has a size of ˜3.5-4 arcmin and stands out at ˜5σ with respect to the background estimate. No features with similar significance were found in four Herschel-observed extragalactic control fields: GOODS-North, Lockman, COSMOS and UDS. The chance of having a similar overdensity in a field with the same number but randomly distributed sources is less than 2 per cent. The clump is also visible as a low-surface-brightness feature in the Planck 857 GHz map. We detect 76 sources at 250 μm (with a signal-to-noise ratio greater than 3), in a region of 4 arcmin radius (or 1.51 ± 0.17 arcmin-2); 43 of those (or 0.86 ± 0.13 arcmin-2) are above a flux density limit of 20 mJy. This is a factor of 3.6 in excess over the average 0.24 ± 0.02 arcmin-2 in the four control fields, considering only the sources above 20 mJy. We also find an excess in the number counts of sources with 250 μm flux densities between 30 and 40 mJy, compared to deep extragalactic blank-field number counts. Assuming a fixed dust temperature (30 K) and emissivity (β = 1.5), a crude, blackbody-derived redshift distribution, zBB, of the detected sources is significantly different from the distributions in the control fields and exhibits a significant peak at zBB ≈ 1.5, although the actual peak redshift is highly degenerate with the temperature. We tentatively suggest, based on zBB and the similar S250/S350 colours of the sources within the peak, that a significant fraction of the sources in the clump may be at a similar redshift. Since the overdensity lies ˜ 7 arcmin south of the z = 2.16 Spiderweb protocluster MRC 1138-26, an intriguing possibility (that is presently unverifiable given the data in hand

  15. Enhanced stability and decolorization of Coomassie Brilliant Blue R-250 by dextran aldehyde-modified horseradish peroxidase.

    Science.gov (United States)

    Altikatoglu, Melda; Celebi, Mithat

    2011-06-01

    Horseradish peroxidase (EC 1.11.1.7) was chemically modified by periodate-activated dextran. The activities of free and modified enzyme against organic-aqueous interface and some chemicals were determined. Modified HRP remained fully active in the presence of organic solvent for 4 h. However, the unmodified enzyme lost 50% of its activity within the first 2 h. The effects of possible inhibitors on enzyme activity were investigated. In addition, Coomassie Brilliant Blue R-250 was efficiently decolorized using the free and modified HRP. After 5 minutes of treatment, the color removal of dye was 80-90%. Modified HRP showed effective performance compared to free HRP.

  16. Improvement of Final Modular Exponentiation Algorithm in Tate Pairing Based on 250 Bits Modular Multiplication Platform%基于250位模乘平台的 Tate 对最终模幂算法的改进

    Institute of Scientific and Technical Information of China (English)

    王晓静

    2014-01-01

    在只支持250 bits模乘的硬件平台上,实现457 bits的二元扩域Tate对Miller算法的(双线性对的一种)最终模幂运算。在计算过程中采用一种改进的Montgomery模乘算法和中国剩余定理算法。通过具体数据实现双线性对最终模幂的运算,使用数学软件Sage来验证这种改进方案的正确性。通过理论分析和数据计算可以证明使用该方案可实现457 bits最终模幂。%The purpose of this article is to realize the 457 bits final modular exponentiation in the Tate pairing Miller algorithm ( one kind of bilinear pairings ) of binary extension field on the hardware platform which only supports 250 bits modular multiplica-tion.In the procedure of calculation , we adopted an improved Montgomery modular multiplication algorithm and Chinese remain-der theorem algorithm .The final modular exponentiation will be realized with definite data , and we will use the mathematical soft-ware Sage to verify the improved scheme .So we can prove that this scheme can realize the 457 bits final modular exponentiation through theory analysis and data calculation .

  17. 经渗硼处理的马氏体时效钢(C-250级)的耐磨性能%Boronizing of Maraging Steel ( C-250 Grade) : Evaluation of Wear Behavior

    Institute of Scientific and Technical Information of China (English)

    S. C. Heck; F. A. P. Fernandes; G. E. Totten; A. Lombardi Neto; L. C. Casteletti

    2012-01-01

    马氏体时效钢(250级)多用于要求高的强度/重量比及良好韧性的场合.这种钢属于高强度钢,达到了常用工程合金所能获得的最高的强度与韧性的结合.表面处理可能是改善这种钢的耐磨性的有效途径.渗硼是使硼渗入金属或合金的表面从而形成金属硼化物的表面化学热处理工艺,既能提高工程零件的表面性能,又不影响基体性能,是一种具有良好发展前景的工艺方法.本文对马氏体时效钢(250级)进行了盐浴渗硼,获得了高硬度的表面层.这种钢经渗硼处理后,其耐磨性能比未经渗硼的有了明显的改善.

  18. Emerging targets in migraine.

    Science.gov (United States)

    Hoffmann, Jan; Goadsby, Peter J

    2014-01-01

    Migraine is a common and highly disabling neurological disorder. Despite the complexity of its pathophysiology, substantial advances have been achieved over the past 20 years in its understanding, as well as the development of pharmacological treatment options. The development of serotonin 5-HT(1B/1D) receptor agonists ("triptans") substantially improved the acute treatment of migraine attacks. However, many migraineurs do not respond satisfactorily to triptans and cardiovascular co-morbidities limit their use in a significant number of patients. As migraine is increasingly considered to be a disorder of the brain, and preclinical and clinical data indicate that the observed vasodilation is merely an epiphenomenon, research has recently focused on the development of neurally acting compounds that lack vasoconstrictor properties. This review highlights the most important pharmacological targets for which compounds have been developed that are highly likely to enter or have already advanced into clinical trials for the acute and preventive treatment of migraine. In this context, preclinical and clinical data on compounds acting on calcitonin gene-related peptide or its receptor, the 5-HT(1F) receptor, nitric oxide synthase, and acid-sensing ion channel blockers are discussed.

  19. EURISOL High Power Targets

    CERN Document Server

    Kadi, Y; Lindroos, M; Ridikas, D; Stora, T; Tecchio, L; CERN. Geneva. BE Department

    2009-01-01

    Modern Nuclear Physics requires access to higher yields of rare isotopes, that relies on further development of the In-flight and Isotope Separation On-Line (ISOL) production methods. The limits of the In-Flight method will be applied via the next generation facilities FAIR in Germany, RIKEN in Japan and RIBF in the USA. The ISOL method will be explored at facilities including ISAC-TRIUMF in Canada, SPIRAL-2 in France, SPES in Italy, ISOLDE at CERN and eventually at the very ambitious multi-MW EURISOL facility. ISOL and in-flight facilities are complementary entities. While in-flight facilities excel in the production of very short lived radioisotopes independently of their chemical nature, ISOL facilities provide high Radioisotope Beam (RIB) intensities and excellent beam quality for 70 elements. Both production schemes are opening vast and rich fields of nuclear physics research. In this article we will introduce the targets planned for the EURISOL facility and highlight some of the technical and safety cha...

  20. Magnetic targeted drug delivery

    Directory of Open Access Journals (Sweden)

    Timothy Wiedmann

    2009-10-01

    Full Text Available Lung cancer is the most common cause of death from cancer in both men and women. Treatment by intravenous or oral administration of chemotherapy agents results in serious and often treatment-limiting side effects. Delivery of drugs directly to the lung by inhalation of an aerosol holds the promise of achieving a higher concentration in the lung with lower blood levels. To further enhance the selective lung deposition, it may be possible to target deposition by using external magnetic fields to direct the delivery of drug coupled to magnetic particles. Moreover, alternating magnetic fields can be used to induce particle heating, which in turn controls the drug release rate with the appropriate thermal sensitive material.With this goal, superparamagetic nanoparticles (SPNP were prepared and characterized, and enhanced magnetic deposition was demonstrated in vitro and in vivo. SPNPs were also incorporated into a lipid-based/SPNP aerosol formulation, and drug release was shown to be controlled by thermal activation. Because of the inherent imaging potential of SPNPs, this use of nanotechnology offers the possibility of coupling the diagnosis of lung cancer to drug release, which perhaps will ultimately provide the “magic bullet” that Paul Ehrlich originally sought.

  1. The target effect: visual memory for unnamed search targets.

    Science.gov (United States)

    Thomas, Mark D; Williams, Carrick C

    2014-01-01

    Search targets are typically remembered much better than other objects even when they are viewed for less time. However, targets have two advantages that other objects in search displays do not have: They are identified categorically before the search, and finding them represents the goal of the search task. The current research investigated the contributions of both of these types of information to the long-term visual memory representations of search targets. Participants completed either a predefined search or a unique-object search in which targets were not defined with specific categorical labels before searching. Subsequent memory results indicated that search target memory was better than distractor memory even following ambiguously defined searches and when the distractors were viewed significantly longer. Superior target memory appears to result from a qualitatively different representation from those of distractor objects, indicating that decision processes influence visual memory.

  2. Application of neural network and MODIS 250 m imagery for estimating suspended sediments concentration in Hangzhou Bay, China

    Science.gov (United States)

    Wang, Fan; Zhou, Bin; Xu, Jianming; Song, Lishong; Wang, Xin

    2009-01-01

    Suspended sediments concentration (SSC) in surface water derived from bottom sediment resuspension or discharge of sediment-laden rivers is an important indication of coastal water quality and changes rapidly in high-energy coastal area. Since artificial neural networks (ANN) had been proven successful in modeling a variety of geophysical transfer functions, an ANN model to simulate the relationship between surface water SSC and satellite-received radiances was employed. In situ SSC measurements from the Hangzhou Bay and the Moderate-resolution Imaging Spectroradiometer (MODIS) 250 m daily products were adopted in this study. Significant correlations were observed between in situ measurements and band 1-2 reflectance values of MODIS images, respectively. Results indicated that application of ANN model with one hidden layer appeared to yield superior simulation performance ( r 2 = 0.98; n = 25) compared with regression analysis method. The RMSE for the ANN model was less than 10%, whereas the RMSE for the regression analysis was more than 25%. Results also showed that different tidal situations affect the model simulation results to some extent. The SSC of surface water in Hangzhou Bay is high and changes rapidly due to tidal flood and ebb during a tidal cycle. The combined utilization of Terra and Aqua MODIS data can capture the tidal cycle induced dynamic of surface water SSC. This study demonstrated that MODIS 250 m daily products and ANN model are useful for monitoring surface SSC dynamic within high-energy coastal water environments.

  3. Downscaling 250-m MODIS growing season NDVI based on multiple-date landsat images and data mining approaches

    Science.gov (United States)

    Gu, Yingxin; Wylie, Bruce K.

    2015-01-01

    The satellite-derived growing season time-integrated Normalized Difference Vegetation Index (GSN) has been used as a proxy for vegetation biomass productivity. The 250-m GSN data estimated from the Moderate Resolution Imaging Spectroradiometer (MODIS) sensors have been used for terrestrial ecosystem modeling and monitoring. High temporal resolution with a wide range of wavelengths make the MODIS land surface products robust and reliable. The long-term 30-m Landsat data provide spatial detailed information for characterizing human-scale processes and have been used for land cover and land change studies. The main goal of this study is to combine 250-m MODIS GSN and 30-m Landsat observations to generate a quality-improved high spatial resolution (30-m) GSN database. A rule-based piecewise regression GSN model based on MODIS and Landsat data was developed. Results show a strong correlation between predicted GSN and actual GSN (r = 0.97, average error = 0.026). The most important Landsat variables in the GSN model are Normalized Difference Vegetation Indices (NDVIs) in May and August. The derived MODIS-Landsat-based 30-m GSN map provides biophysical information for moderate-scale ecological features. This multiple sensor study retains the detailed seasonal dynamic information captured by MODIS and leverages the high-resolution information from Landsat, which will be useful for regional ecosystem studies.

  4. Serendipitous detection of an overdensity of Herschel-SPIRE 250 micron sources south of MRC1138-26

    CERN Document Server

    Valtchanov, Ivan; Berta, S; Chapin, E; Coia, D; Conversi, L; Dannerbauer, H; Domínguez-Sánchez, H; Rawle, T D; Sánchez-Portal, M; Santos, J S; Temporin, S

    2013-01-01

    We report the serendipitous detection of a significant overdensity of Herschel-SPIRE 250 micron sources in the vicinity of MRC1138-26. We use an adaptive kernel density estimate to quantify the significance, including a comparison with other fields. The overdensity has a size of ~3.5-4' and stands out at ~5sigma with respect to the background estimate. No features with similar significance were found in four extragalactic control fields: GOODS-North, Lockman, COSMOS and UDS. The chance of having a similar overdensity in a field with the same number but randomly distributed sources is less than 2%. The clump is also visible as a low surface brightness feature in the Planck 857 GHz map. We detect 76 sources at 250 micron (with a signal-to-noise ratio greater than 3), in a region of 4' radius; 43 of those are above a flux density limit of 20 mJy. This is a factor of 3.6 in excess over the average in the four control fields, considering only the sources above 20 mJy. We also find an excess in the number counts of...

  5. HIC1 interacts with a specific subunit of SWI/SNF complexes, ARID1A/BAF250A

    Energy Technology Data Exchange (ETDEWEB)

    Van Rechem, Capucine; Boulay, Gaylor [CNRS UMR 8161, Institut de Biologie de LILLE, Universite de Lille Nord de FRANCE, Institut PASTEUR de LILLE, IFR 142, 1 Rue Calmette, 59017 LILLE Cedex (France); Leprince, Dominique, E-mail: dominique.leprince@ibl.fr [CNRS UMR 8161, Institut de Biologie de LILLE, Universite de Lille Nord de FRANCE, Institut PASTEUR de LILLE, IFR 142, 1 Rue Calmette, 59017 LILLE Cedex (France)

    2009-08-07

    HIC1, a tumor suppressor gene epigenetically silenced in many human cancers encodes a transcriptional repressor involved in regulatory loops modulating p53-dependent and E2F1-dependent cell survival and stress responses. HIC1 is also implicated in growth control since it recruits BRG1, one of the two alternative ATPases (BRM or BRG1) of SWI/SNF chromatin-remodeling complexes to repress transcription of E2F1 in quiescent fibroblasts. Here, through yeast two-hybrid screening, we identify ARID1A/BAF250A, as a new HIC1 partner. ARID1A/BAF250A is one of the two mutually exclusive ARID1-containing subunits of SWI/SNF complexes which define subsets of complexes endowed with anti-proliferative properties. Co-immunoprecipitation assays in WI38 fibroblasts and in BRG1-/- SW13 cells showed that endogenous HIC1 and ARID1A proteins interact in a BRG1-dependent manner. Furthermore, we demonstrate that HIC1 does not interact with BRM. Finally, sequential chromatin immunoprecipitation (ChIP-reChIP) experiments demonstrated that HIC1 represses E2F1 through the recruitment of anti-proliferative SWI/SNF complexes containing ARID1A.

  6. Topographic Digital Raster Graphics, DRG - 1:250,000 Topo - Quads (7.5 Minute), Published in 1996, Arizona State Land Department.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Topographic Digital Raster Graphics dataset, was produced all or in part from Hardcopy Maps information as of 1996. It is described as 'DRG - 1:250,000 Topo -...

  7. Anti-inflammatory effects of salmeterol/fluticasone propionate 50/250 mcg combination therapy in Japanese patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Asai K

    2015-04-01

    Full Text Available Kazuhisa Asai,1 Akihiro Kobayashi,2 Yukio Makihara,3 Malcolm Johnson4 1Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan; 2Biomedical Data Sciences, 3Medical Affairs Respiratory Department, GlaxoSmithKline, Tokyo, Japan; 4Respiratory Global Franchise, GlaxoSmithKline, Uxbridge, UK Purpose: Using sputum neutrophils as the primary measure, and other inflammation biomarkers, this study evaluated the anti-inflammatory effects of the combination salmeterol 50 mcg and fluticasone propionate 250 mcg (SFC 250 in Japanese patients with chronic obstructive pulmonary disease (COPD. Patients and methods: Patients were treated in a randomized, double-blind, parallel group, placebo-controlled trial with SFC 250 twice daily (n=26 or placebo (n=26 for 12 weeks. At the start and end of treatment, inflammation biomarkers (sputum and serum, lung function, and health status (COPD Assessment Test [CAT] questionnaire were measured. Results: Although a numerical decrease in differential neutrophil count was observed from baseline, SFC 250 did not significantly reduce sputum neutrophils compared with placebo, nor were there significant changes from baseline in the other biomarkers (sputum or serum, lung function, or CAT, versus placebo. Squamous epithelial cell contamination in some sputum samples rendered them unacceptable for analysis, which reduced the sample size to n=19 (SFC 250 and n=10 (placebo. However, inclusion of contaminated samples did not affect the overall trend of the outcome. Ad hoc bootstrap statistical analysis showed a 27.9% (SFC 250 and 1.3% (placebo decrease in sputum neutrophils. Sputum IL-8 decreased by 43.2% after SFC 250 but increased by 48.3% with placebo. Responder analyses showed 42% of patients had ≥20% decrease in neutrophils from baseline; and 47% of patients had a ≥200 pg/mL change in sputum IL-8 following SFC 250 versus 20% after placebo; both changes are considered clinically

  8. Molecular targeting of carbonic anhydrase IX in mice with hypoxic HT29 colorectal tumor xenografts.

    Directory of Open Access Journals (Sweden)

    Sean Carlin

    Full Text Available BACKGROUND: Carbonic anhydrase IX (CAIX is a membrane spanning protein involved in the enzymatic regulation of tumor acid-base balance. CAIX has been shown to be elevated in a number of hypoxic tumor types. The purpose of this study was to determine the efficiency of intact and IgG fragments of cG250 to target CAIX in vivo in a hypoxic tumor model. METHODOLOGY/PRINCIPAL FINDINGS: Conventional biodistribution studies were performed with (111In-DO3A-cG250, (111In-DO3A-F(ab'(2-cG250 and (111In-DO3A-Fab-cG250. Additional ex vivo analysis of the tumor was performed with markers for tumor hypoxia, blood perfusion and endogenous CAIX expression. All four data sets were digitally correlated to determine the optimal agent for determining hypoxia in a HT29 colon cancer xenograft. The HT29 human colorectal tumor xenografts show strong CAIX expression in hypoxic areas of poor blood perfusion. The intact IgG had an initial high focal uptake at the periphery of these hypoxic regions and penetration into the areas of highest CAIX expression over the 7-day study period. The lower molecular weight antibody fragments had a faster uptake into areas of high CAIX expression, but had a much lower absolute uptake at the optimal imaging times. CONCLUSIONS/SIGNIFICANCE: For the clinical detection of hypoxia induced CAIX using cG250 antibody based agents, imaging with the intact IgG at 7 days post injection would allow for the most sensitive and accurate detection of CAIX.

  9. MONTHLY VARIABILITY OF TOTAL SUSPENDED MATTER (TSM) MAPPING USING MODIS 250M TO SUPPORT MARINE CULTURE AT MOROTAI ISLAND, NORTH MALUKU

    OpenAIRE

    KOMANG IWAN SUNIADA

    2015-01-01

    This study was conducted to provide an information of Total Suspended Matter concentration and its monthly variability using dialy data of Terra/ Aqua MOD IS level 1 b with spatial resolution 250m imagery at Morotai Island, Northern Maluku. TSM is one of the water quality key parameter to support finding suitable area which is an important step for marine culture activity. Dialy Aqua/Terra MODIS level lb, 250m dataset was downloaded freely from Goddard Space Flight Center, LAADS Web (http ://...

  10. Facility target insert shielding assessment

    Energy Technology Data Exchange (ETDEWEB)

    Mocko, Michal [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-06

    Main objective of this report is to assess the basic shielding requirements for the vertical target insert and retrieval port. We used the baseline design for the vertical target insert in our calculations. The insert sits in the 12”-diameter cylindrical shaft extending from the service alley in the top floor of the facility all the way down to the target location. The target retrieval mechanism is a long rod with the target assembly attached and running the entire length of the vertical shaft. The insert also houses the helium cooling supply and return lines each with 2” diameter. In the present study we focused on calculating the neutron and photon dose rate fields on top of the target insert/retrieval mechanism in the service alley. Additionally, we studied a few prototypical configurations of the shielding layers in the vertical insert as well as on the top.

  11. The OLYMPUS internal hydrogen target

    Energy Technology Data Exchange (ETDEWEB)

    Bernauer, J.C., E-mail: bernauer@mit.edu [Massachusetts Institute of Technology, Laboratory for Nuclear Science, Cambridge, MA 02139 (United States); Carassiti, V.; Ciullo, G. [Istituto Nazionale di Fisica Nucleare and Università, 44100 Ferrara (Italy); Henderson, B.S. [Massachusetts Institute of Technology, Laboratory for Nuclear Science, Cambridge, MA 02139 (United States); Ihloff, E.; Kelsey, J. [Massachusetts Institute of Technology, Laboratory for Nuclear Science, Cambridge, MA 02139 (United States); MIT-Bates Linear Accelerator Center, Middleton, MA 01949 (United States); Lenisa, P. [Istituto Nazionale di Fisica Nucleare and Università, 44100 Ferrara (Italy); Milner, R. [Massachusetts Institute of Technology, Laboratory for Nuclear Science, Cambridge, MA 02139 (United States); MIT-Bates Linear Accelerator Center, Middleton, MA 01949 (United States); Schmidt, A. [Massachusetts Institute of Technology, Laboratory for Nuclear Science, Cambridge, MA 02139 (United States); Statera, M. [Istituto Nazionale di Fisica Nucleare and Università, 44100 Ferrara (Italy)

    2014-08-01

    An internal hydrogen target system was developed for the OLYMPUS experiment at DESY, in Hamburg, Germany. The target consisted of a long, thin-walled, tubular cell within an aluminum scattering chamber. Hydrogen entered at the center of the cell and exited through the ends, where it was removed from the beamline by a multistage pumping system. A cryogenic coldhead cooled the target cell to counteract heating from the beam and increase the density of hydrogen in the target. A fixed collimator protected the cell from synchrotron radiation and the beam halo. A series of wakefield suppressors reduced heating from beam wakefields. The target system was installed within the DORIS storage ring and was successfully operated during the course of the OLYMPUS experiment in 2012. Information on the design, fabrication, and performance of the target system is reported.

  12. Oxide Fiber Targets at ISOLDE

    CERN Document Server

    Köster, U; Carminati, D; Catherall, R; Cederkäll, J; Correia, J G; Crepieux, B; Dietrich, M; Elder, K; Fedosseev, V; Fraile-Prieto, L M; Franchoo, S; Fynbo, H O U; Georg, U; Giles, T; Joinet, A; Jonsson, O C; Kirchner, R; Lau, C; Lettry, Jacques; Maier, H J; Mishin, V I; Oinonen, M; Peräjärvi, K; Ravn, H L; Rinaldi, T; Santana-Leitner, M; Wahl, U; Weissman, L

    2003-01-01

    Many elements are rapidly released from oxide matrices. Some oxide powder targets show a fast sintering, thus losing their favorable release characteristics. Loosely packed oxyde fiber targets are less critical since they may maintain their open structure even when starting to fuse together at some contact points. The experience with various oxyde fiber targets (titania, zirconia, ceria and thoria) used in the last years at ISOLDE is reviewed. For short-lived isotopes of Cu, Ga and Xe the zirconia and ceria targets respectively provided significantly higher yields than any other target (metal foils, oxide powders, etc.) tested before. Titania fibers, which were not commercially available, were produced in a relic process by impregnation of a rayon felt in a titanium chloride solution and subsequent calcination by heating the dried felt in air. Thoria fibers were obtained either by the same process or by burning commercial gas lantern mantle cloth. In the future a beryllia fiber target could be used to produce...

  13. Learning About Intervention Target Zones

    OpenAIRE

    Klein, Michael W; Karen K. Lewis

    1991-01-01

    This paper provides a framework for evaluating how market participants' beliefs about foreign exchange target zones change as they learn about central bank intervention policy. In order to examine this behavior, we first generalize the standard target zone model to allow for intra-marginal intervention. Intra-marginal intervention implies that the position of market participants' beliefs about the target zone can be determined from their beliefs about the likelihood of intervention. As an app...

  14. CRH250动车组万向联轴器检修工艺的分析%Analysis of the Testing and Maintenance Process of CRH250 Cardan Shaft

    Institute of Scientific and Technical Information of China (English)

    徐汇音

    2013-01-01

    CRH250动车组的万向联轴器在动车运行中,既要传递牵引力矩又要适应各种复杂的运动关系,以保证轮对的自由运动.通过对动车组万向联轴器的结构原理阐述,提出了列车运行里程数与万向联轴器对应的检测原则,分析了不同运行里程后检测维护的工艺及各零部件处理的对策,以确保列车运行时的安全性及可靠性.

  15. Data Mining for Target Marketing

    Science.gov (United States)

    Levin, Nissan; Zahavi, Jacob

    Targeting is the core of marketing management. It is concerned with offering the right product/service to the customer at the right time and using the proper channel. In this chapter we discuss how Data Mining modeling and analysis can support targeting applications. We focus on three types of targeting models: continuous-choice models, discrete-choice models and in-market timing models, discussing alternative modeling for each application and decision making. We also discuss a range of pitfalls that one needs to be aware of in implementing a data mining solution for a targeting problem.

  16. Inflation Targeting and Inflation Persistence

    Institute of Scientific and Technical Information of China (English)

    GEORGE; J.BRATSIOTIS; JAKOB; MADSEN; CHRISTOPHER; MARTIN

    2015-01-01

    This paper argues that the adoption of an inflation target reduces the persistence of inflation.We develop the theoretical literature on inflation persistence by introducing a Taylor Rule for monetary policy into a model of persistence and showing that inflation targets reduce inflation persistence.We investigate changes in the time series properties of inflation in seven countries that introduced inflation targets in the late 1980s or early 1990s.We find that the persistence of inflation is greatly reduced or eliminated following the introduction of inflation targets.

  17. Limits of Inflation Targeting Strategy

    Directory of Open Access Journals (Sweden)

    Aura Niculescu

    2006-03-01

    Full Text Available This paper evaluates the trade-off between output volatility and the variability of the inflation rate around its target (Romanian case. The optimal choice for National Bank of Romania (NBR, in our opinion, is the flexible inflation targeting. For this purpose, NBR must explain the loss function and the optimal monetary policy rule. We then argued that this Romanian authority – NBR – can substantially improve its credibility under inflation targeting policy regime by becoming more accountable and transparent. Is the direct inflation targeting the best choice for the monetary policy regime in Romanian economy?

  18. Target engagement in lead generation.

    Science.gov (United States)

    Durham, Timothy B; Blanco, Maria-Jesus

    2015-03-01

    The pharmaceutical industry is currently facing multiple challenges, in particular the low number of new drug approvals in spite of the high level of R&D investment. In order to improve target selection and assess properly the clinical hypothesis, it is important to start building an integrated drug discovery approach during Lead Generation. This should include special emphasis on evaluating target engagement in the target tissue and linking preclinical to clinical readouts. In this review, we would like to illustrate several strategies and technologies for assessing target engagement and the value of its application to medicinal chemistry efforts.

  19. Therapeutic Targeting of Telomerase

    Directory of Open Access Journals (Sweden)

    Kathrin Jäger

    2016-07-01

    Full Text Available Telomere length and cell function can be preserved by the human reverse transcriptase telomerase (hTERT, which synthesizes the new telomeric DNA from a RNA template, but is normally restricted to cells needing a high proliferative capacity, such as stem cells. Consequently, telomerase-based therapies to elongate short telomeres are developed, some of which have successfully reached the stage I in clinical trials. Telomerase is also permissive for tumorigenesis and 90% of all malignant tumors use telomerase to obtain immortality. Thus, reversal of telomerase upregulation in tumor cells is a potential strategy to treat cancer. Natural and small-molecule telomerase inhibitors, immunotherapeutic approaches, oligonucleotide inhibitors, and telomerase-directed gene therapy are useful treatment strategies. Telomerase is more widely expressed than any other tumor marker. The low expression in normal tissues, together with the longer telomeres in normal stem cells versus cancer cells, provides some degree of specificity with low risk of toxicity. However, long term telomerase inhibition may elicit negative effects in highly-proliferative cells which need telomerase for survival, and it may interfere with telomere-independent physiological functions. Moreover, only a few hTERT molecules are required to overcome senescence in cancer cells, and telomerase inhibition requires proliferating cells over a sufficient number of population doublings to induce tumor suppressive senescence. These limitations may explain the moderate success rates in many clinical studies. Despite extensive studies, only one vaccine and one telomerase antagonist are routinely used in clinical work. For complete eradication of all subpopulations of cancer cells a simultaneous targeting of several mechanisms will likely be needed. Possible technical improvements have been proposed including the development of more specific inhibitors, methods to increase the efficacy of vaccination

  20. 肝脂酶-250G/A基因多态性与阿尔茨海默病相关性研究%Association study of the hepatic lipase gene-250G/A promoter polymorphism and Alzheimer's disease

    Institute of Scientific and Technical Information of China (English)

    王娟; 肖志杰; 陈卫蓉

    2012-01-01

    目的:探讨常见肝脂酶启动子基因-250G/A多态性对阿尔茨海默病(AD)患者发病风险及认知功能的影响. 方法:采用病例对照研究,随机抽取湖南长沙地区汉族人群104例散发性AD患者(AD组)以及104名认知功能正常者(对照组)为研究对象,应用聚合酶链反应-限制性片段长度多态性方法测定肝脂酶-250G/A基因多态性,采用成人韦氏记忆量表(WMS)及威斯康辛卡片分类测验(WCST)进行认知功能测评. 结果:两组间GG、GA及AA 3种基因型分布差异有统计学意义(x2=7.925,P=0.019),其中AD组GG型频率显著高于对照组(27.9%和13.5%;x2 =5.233,P=0.022);GA+AA型频率显著低于对照组(72.1%和86.5%;x2=6.595,P=0.016);两组间等位基因频率比较差异无统计学意义(x2 =0.731,P>0.05).肝脂酶A等位基因携带者(GA+ AA型)WMS的短时记忆能力得分显著增高(P<0.05),而长时记忆和瞬时记忆能力得分差异无统计学意义(P>0.05).多因素Logistic回归显示,A等位基因是AD的独立保护因素之一. 结论:肝脂酶-250G/A遗传变异与AD相关,A等位基因对AD发病及短时记忆功能可能有独立保护作用.%Objective: This study aimed to assess the effect of single-nucleotide polymorphism (SNP) in the hepatic lipase (HL) promoter - 250G/A on the risk of Alzheimers disease(AD) and cognitive function. Method:Using case-control study,a total of 104 sporadic AD patients and 104 individuals without cognitive impairment from a population of Chinese Han nationality in Changsha area was studied. The polymorphism of LIPC -250G/A was determined by the restriction fragment length polymorphism (RFLP) amplified by polymerase chain reaction ( PCR) . The evaluation of cognitive function was tested by Wechsler memory scale ( WMS) and Wisconsin card sorting test(WCST). Results: There were significant differences in the frequencies of three genotypes (GG,GA and AA) between AD patients and controls(x2 = 7. 925 ,P =0

  1. Transverse target spin asymmetries on a proton target at COMPASS

    CERN Document Server

    Richter, Andreas

    2009-01-01

    Transversity and transverse momentum-dependent parton distribution functions (TMDs) are been measured in semi-inclusive deep inelastic scattering (SIDIS) by using a transversely polarized target at the COMPASS experiment. COMPASS is a fixed target experiment at the CERN M2 beamline, which provides a 160GeV/c polarized m+ beam. In the years 2002-2004 COMPASS has collected data with a transversely polarized deuteron 6LiD target. In 2007, COMPASS has used for the first time a proton NH3 target. To access transversity COMPASS has used three different quark polarimeters: the Collins effect, responsible for an azimuthal asymmetry in the single hadron distribution, azimuthal target spin asymmetries of charged hadron pairs and the transverse polarisation of L hyperons. Beside this also the Sivers asymmetry arising from the correlation between the transverse nucleon spin and the quark intrinsic transverse momentum was measured. European

  2. Mapping rice-fallow cropland areas for short-season grain legumes intensification in South Asia using MODIS 250 m time-series data

    Science.gov (United States)

    Gumma, Murali Krishna; Thenkabail, Prasad S.; Teluguntla, Pardhasaradhi G.; Rao, Mahesh N.; Mohammed, Irshad A.; Whitbread, Anthony M.

    2016-01-01

    study established cropland classes based on the every 16-day 250 m normalized difference vegetation index (NDVI) time series for one year (June 2010–May 2011) of Moderate Resolution Imaging Spectroradiometer (MODIS) data, using spectral matching techniques (SMTs), and extensive field knowledge. Map accuracy was evaluated based on independent ground survey data as well as compared with available sub-national level statistics. The producers’ and users’ accuracies of the cropland fallow classes were between 75% and 82%. The overall accuracy and the kappa coefficient estimated for rice classes were 82% and 0.79, respectively. The analysis estimated approximately 22.3 Mha of suitable rice-fallow areas in South Asia, with 88.3% in India, 0.5% in Pakistan, 1.1% in Sri Lanka, 8.7% in Bangladesh, 1.4% in Nepal, and 0.02% in Bhutan. Decision-makers can target these areas for sustainable intensification of short-duration grain legumes.

  3. On artefact-free reconstruction of low-energy (30-250 eV) electron holograms

    CERN Document Server

    Latychevskaia, Tatiana; Escher, Conrad; Fink, Hans-Werner

    2013-01-01

    Low-energy electrons (30-250 eV) have been successfully employed for imaging individual biomolecules. The most simple and elegant design of a low-energy electron microscope for imaging biomolecules is a lensless setup that operates in the holographic mode. In this work we address the problem associated with the reconstruction from the recorded holograms. We discuss the twin image problem intrinsic to inline holography and the problem of the so-called biprism-like effect specific to low-energy electrons. We demonstrate how the presence of the biprism-like effect can be efficiently identified and circumvented. The presented sideband filtering reconstruction method eliminates the twin image and allows for reconstruction despite the biprism-like effect, which we demonstrate on both, simulated and experimental examples.

  4. Multiplicity structure of inclusive diffraction in. pi. sup + p and K sup + p interactions at 250 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Begalli, M.; Endler, A.M.F. (Centro Brasileiro des Pesquisas Fisicas, Rio de Janeiro, RJ (Brazil)); Botterweck, F.; Charlet, M.; Kittel, W. (Nijmegen Univ. (Netherlands) NIKHEF-H, Nijmegen (Netherlands)); Chliapnikov, P.V.; Tchikilev, O.G. (Inst. for High Energy Physics, Protvino (Russia)); Wolf, E.A. de; Olkiewicz, K.; Verbeure, F. (Inter-Univ. Inst. for High Energies, Brussels (Belgium) Univ. Instell

    1992-02-01

    Results on the multiplicity structure of diffractively excited meson and proton systems in {pi}{sup +}/K{sup +}p interactions at 250 GeV/c are presented for diffractive masses up to about 9 GeV. The energy dependence of the average charge multiplicity and the shape of the multiplicity distribution in terms of KNO-scaling and Negative Binomial distribution are investigated. The diffractive systems are compared to e{sup +}e{sup -}, lh and non-diffractive hh final states as suggested by modern approaches of the Pomeron-hadron collision. Systematic differences are found between diffractive meson and proton systems but also between diffraction and the reactions compared to. (orig.).

  5. Multiplicity structure of inclusive diffraction in. pi. sup + p and K sup + p interactions at 250 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Begalli, M.; Endler, A.M.F. (Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro (Brazil)); Botterweck, F.; Charlet, M.; Kittel, W. (Katholieke Univ. Nijmegen (Netherlands) Nationaal Inst. voor Kernfysica en Hoge-Energiefysica (NIKHEF), Nijmegen (Netherlands)); Boettcher, H.; Friebel, W.; Naumann, T.; Roloff, H.E.; Wischnewski, R. (DESY - Inst. fuer Hochenergiephysik, Zeuthen (Germany)); Chliapnikov, P.V.; Tchikilev, O.G. (Institut Fiziki Vysokikh Ehnergij, Protvino (Russia)); Wolf, E.A. de; Olkiewicz, K.; Verbeure, F. (Inter-Univ. Inst. for High Energies, Brussels (Belgium) Universitaire Instelling Antwerpen, Wilrijk (Belgium)); Dziunikowska, K.; Eskreys, A. (Institute of Physics and Nuclear Techniques, Cracow (Poland) Institute of Nuclear Physics, Cracow (Poland)); Gulkanyan, G.R.; Megrabyan, S.S. (Institute of Physics, Erevan (Armenia)); Garutchava, Z.S.; Tomaradze, A.G. (Tbilisskij Gosudarstvennyj Univ., Tbilisi (Georgia). Inst. Vysokikh Ehnergij); Tikhonova, L.A.; EHS/NA22 Collaboration

    1992-09-01

    Results on the multiplicity structure of diffractively excited meson and proton systems in {pi}{sup +}/K{sup +}p interactions at 250 GeV/c are presented for diffractive masses up to about 9 GeV/c. The energy dependence of the average charge multiplicity and the shape of the multiplicity distribution in terms of KNO-scaling and negative binomial distribution are investigated. The diffractive systems are compared to e{sup +}e{sup -}, lh and non-diffractive hh final states as suggested by modern approaches of the Pomeron-hadron collision. Systematic differences are found between diffractive meson and proton systems but also between diffraction and the reactions compared to. (orig.).

  6. CHESS Pdet-F1ow Plot诊断前列腺增生症250

    Institute of Scientific and Technical Information of China (English)

    张利国; 李雪原; 于满

    2004-01-01

    @@ 前列腺增生症是老年男性的常见病,随着中国社会人口老龄化进程的加快,前列腺增生症的发病率有增加的趋势.尿动力学之压力-流率检查是诊断前列腺增生所致膀胱流出道梗阻的金标准,对压力-流率检查的众多参数有多种分析方法,本文应用CHESS Pdet-Flow Plot诊断前列腺增生症250例,报告如下.

  7. On-chip measurements of Brownian relaxation of magnetic beads with diameters from 10 nm to 250 nm

    DEFF Research Database (Denmark)

    Østerberg, Frederik Westergaard; Rizzi, Giovanni; Hansen, Mikkel Fougt

    2013-01-01

    We demonstrate the use of planar Hall effect magnetoresistive sensors for AC susceptibility measurements of magnetic beads with frequencies ranging from DC to 1 MHz. This wide frequency range allows for measuring Brownian relaxation of magnetic beads with diameters ranging from 10 nm to 250 nm...... to sedimentation, magnetic trapping, and signal per bead. Among the investigated beads, we conclude that the beads with a nominal diameter of 80 nm are best suited for future on-chip volume-based biosensing experiments using planar Hall effect sensors........ Brownian relaxation is measured for six different magnetic bead types and their hydrodynamic diameters are determined. The hydrodynamic diameters are found to be within 40% of the nominal bead diameters. We discuss the applicability of the different bead types for volume-based biosensing with respect...

  8. Facebook公布四季度财报.目前拥有250万广告主

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    根据马克.扎克伯格的四季度财报电话会议,Facebook似乎在各个方面都取得了不错的增长。Facebook现在每天的视频观看时间长达1亿小时。Facebook目前拥有250万位广告主,它的主页也吸引了5000万个商家进驻,高于上季度的4500万。用户在这些主页上留下了数十亿计的评论。

  9. Dilatometer setup for low coefficient of thermal expansion materials measurements in the 140 K-250 K temperature range

    Science.gov (United States)

    Spannagel, Ruven; Hamann, Ines; Sanjuan, Josep; Schuldt, Thilo; Gohlke, Martin; Johann, Ulrich; Weise, Dennis; Braxmaier, Claus

    2016-10-01

    Space applications demand light weight materials with excellent dimensional stability for telescopes, optical benches, optical resonators, etc. Glass-ceramics and composite materials can be tuned to reach very low coefficient of thermal expansion (CTE) at different temperatures. In order to determine such CTEs, very accurate setups are needed. Here we present a dilatometer that is able to measure the CTE of a large variety of materials in the temperature range of 140 K to 250 K. The dilatometer is based on a heterodyne interferometer with nanometer noise levels to measure the expansion of a sample when applying small amplitude controlled temperature signals. In this article, the CTE of a carbon fiber reinforced polymer sample has been determined with an accuracy in the 10-8 K-1 range.

  10. Construction and start-up of a 250 kW natural gas fueled MCFC demonstration power plant

    Energy Technology Data Exchange (ETDEWEB)

    Figueroa, R.A.; Carter, J.; Rivera, R.; Otahal, J. [San Diego Gas & Electric, CA (United States)] [and others

    1996-12-31

    San Diego Gas & Electric (SDG&E) is participating with M-C Power in the development and commercialization program of their internally manifolded heat exchanger (IMHEX{reg_sign}) carbonate fuel cell technology. Development of the IMHEX technology base on the UNOCAL test facility resulted in the demonstration of a 250 kW thermally integrated power plant located at the Naval Air Station at Miramar, California. The members of the commercialization team lead by M-C Power (MCP) include Bechtel Corporation, Stewart & Stevenson Services, Inc., and Ishikawajima-Harima Heavy Industries (IHI). MCP produced the fuel cell stack, Bechtel was responsible for the process engineering including the control system, Stewart & Stevenson was responsible for packaging the process equipment in a skid (pumps, desulfurizer, gas heater, turbo, heat exchanger and stem generator), IHI produced a compact flat plate catalytic reformer operating on natural gas, and SDG&E assumed responsibility for plant construction, start-up and operation of the plant.

  11. A reflectivity profilometer for the optical characterisation of grade reflectivity mirrors in the 250 nm - 1100 nm spectral region

    Energy Technology Data Exchange (ETDEWEB)

    Colucci, Alessandro; Nichelatti, Enrico [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Innovazione

    1998-04-01

    It`s developed the prototype of an instrument that can be used for the optical characterisation of graded reflectivity mirrors at any wavelength in the spectral region from 250 nm to 1100 nm. The instrument utilises a high-pressure Xe arc lamp as light source. Light is spectrally filtered by means of a grating monochromator. The sample is illuminated with an image of the monochromator exit slit. After reflection from the sample, this image is projected onto a 1024-elements charge-coupled device linear array driven by a digital frame board and interfaced with a personal computer. It`s tested the instrument accuracy by comparing measurement results with the corresponding ones obtained by means of a laser scanning technique. Measurement Rms repeatability has been estimated to be approximately of 0.8%. [Italiano] E` stato sviluppato il prototipo di uno strumento per la catatterizzazione ottica di specchi a riflettivita` variabile, operante a qualsiasi lunghezza d`onda nell`intervallo spettrale da 250 nm a 1100 nm. La sorgente dello strumento e` una lampada ad arco allo Xenon ad alta pressione. La luce e` filtrata spettralmente per mezzo di un monocromatore a reticolo. Il campione viene illuminato da un`immagine della fenditura d`uscita del monocromatore. Dopo essere stata riflessa dal campione, questa immagine viene proiettata su un array CCD lineare a 1024 elementi, connesso elettronicamente a una scheda digitale e interfacciato a un personal computer. L`accuratezza dello strumento e` stata verificata confrontando alcune misure con le corrispondenti misure ottenute mediante una tecnica a scansione laser. La ripetibilita` RMS delle misure e` stata stimata essere circa dello 0.8%.

  12. Urinary Concentrations and Antibacterial Activities of Nitroxoline at 250 Milligrams versus Trimethoprim at 200 Milligrams against Uropathogens in Healthy Volunteers

    Science.gov (United States)

    Münch, Fabian; Pilatz, Adrian; Bärmann, Birte; Weidner, Wolfgang; Wagenlehner, Christine M.; Straubinger, Marion; Blenk, Holger; Pfister, Wolfgang; Kresken, Michael; Naber, Kurt G.

    2014-01-01

    Because of the increasing bacterial resistance of uropathogens against standard antibiotics, such as trimethoprim (TMP), older antimicrobial drugs, such as nitroxoline (NTX), should be reevaluated. This randomized crossover study investigated the urinary concentrations of parent drugs and their metabolites and their antibacterial activities (urinary inhibitory titers [UITs] and urinary bactericidal titers [UBTs]) against uropathogens at three different urinary pH values within 24 h in six healthy volunteers after a single oral dose of NTX at 250 mg versus TMP at 200 mg. In three additional volunteers, urinary bactericidal kinetics (UBK) were studied after oral administration of NTX at 250 mg three times a day. The mean urinary concentrations of NTX and NTX sulfate in 24 h were 0.012 to 0.507 mg/liter and 0.28 to 27.83 mg/liter, respectively. The mean urinary concentrations of TMP were 18.79 to 41.59 mg/liter. The antibacterial activity of NTX was higher in acidic urine than in alkaline urine, and that of TMP was higher in alkaline urine than in acidic urine. The UITs and UBTs of NTX were generally lower than those of TMP except for a TMP-resistant Escherichia coli strain, for which NTX showed higher UITs/UBTs than did TMP. UBK showed mainly bacteriostatic activity of NTX in urine. NTX exhibits mainly bacteriostatic activity and TMP also shows bactericidal activity in urine against susceptible strains. NTX is a more active antibacterial in acidic urine, and TMP is more active in alkaline urine. The cumulative effects of multiple doses or inhibition of bacterial adherence could not be evaluated. (This study has been registered at EudraCT under registration no. 2009-015631-32.) PMID:24217699

  13. ISOLDE target zone control room

    CERN Multimedia

    2016-01-01

    Operating the ISOLDE target handling robots from the dedicated control room in building 197. Monitors showing the movements of the robots (GPS in this case) in the target zone. The footage shows the actual operation by the operator as well as the different equipment such as camera electronics, camera motor controls, camera monitors and Kuka robot controls touch panel.

  14. The Bering Target Tracking Instrumentation

    DEFF Research Database (Denmark)

    Denver, Troelz; Jørgensen, John Leif; Betto, Maurizio;

    2003-01-01

    The key science instrument on the Bering satellite mission is a relative small telescope with an entrance aperture of 300 mm and a focal length between 500 and 1000 mm. The detection of potential targets is performed by one of the target scanning advanced stellar compasses (ASCs). This procedure...

  15. Treating rheumatoid arthritis to target

    DEFF Research Database (Denmark)

    Smolen, Josef S; Breedveld, Ferdinand C; Burmester, Gerd R

    2016-01-01

    BACKGROUND: Reaching the therapeutic target of remission or low-disease activity has improved outcomes in patients with rheumatoid arthritis (RA) significantly. The treat-to-target recommendations, formulated in 2010, have provided a basis for implementation of a strategic approach towards...

  16. Targeting vaccines to dendritic cells

    DEFF Research Database (Denmark)

    Foged, Camilla; Sundblad, Anne; Hovgaard, Lars

    2002-01-01

    delivery systems (DDS) with adjuvant effect that target DC directly and induce optimal immune responses. This paper will review the current knowledge of DC physiology as well as the progress in the field of novel vaccination strategies that directly or indirectly aim at targeting DC....

  17. Treating rheumatoid arthritis to target

    DEFF Research Database (Denmark)

    Smolen, Josef S; Aletaha, Daniel; Bijlsma, Johannes W J;

    2010-01-01

    BACKGROUND: Aiming at therapeutic targets has reduced the risk of organ failure in many diseases such as diabetes or hypertension. Such targets have not been defined for rheumatoid arthritis (RA). OBJECTIVE: /st> To develop recommendations for achieving optimal therapeutic outcomes in RA. METHODS...

  18. Oxide fiber targets at ISOLDE

    DEFF Research Database (Denmark)

    Köster, U.; Bergmann, U.C.; Carminati, D.

    2003-01-01

    Many elements are rapidly released from oxide matrices. Some oxide powder targets show a fast sintering, thus losing their favorable release characteristics. Loosely packed oxide fiber targets are less critical since they may maintain their open structure even when starting to fuse together at so...

  19. Dual targeting of peroxisomal proteins

    Directory of Open Access Journals (Sweden)

    Julia eAst

    2013-10-01

    Full Text Available Cellular compartmentalization into organelles serves to separate biological processes within the environment of a single cell. While some metabolic reactions are specific to a single organelle, others occur in more than one cellular compartment. Specific targeting of proteins to compartments inside of eukaryotic cells is mediated by defined sequence motifs. To achieve multiple targeting to different compartments cells use a variety of strategies. Here, we focus on mechanisms leading to dual targeting of peroxisomal proteins. In many instances, isoforms of peroxisomal proteins with distinct intracellular localization are encoded by separate genes. But also single genes can give rise to differentially localized proteins. Different isoforms can be generated by use of alternative transcriptional start sites, by differential splicing or ribosomal read-through of stop codons. In all these cases different peptide variants are produced, of which only one carries a peroxisomal targeting signal. Alternatively, peroxisomal proteins contain additional signals that compete for intracellular targeting. Dual localization of proteins residing in both the cytoplasm and in peroxisomes may also result from use of inefficient targeting signals. The recent observation that some bona fide cytoplasmic enzymes were also found in peroxisomes indicates that dual targeting of proteins to both the cytoplasm and the peroxisome might be more widespread. Although current knowledge of proteins exhibiting only partial peroxisomal targeting is far from being complete, we speculate that the metabolic capacity of peroxisomes might be larger than previously assumed.

  20. Target-Searching on Percolation

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    We study target-searching processes on a percolation, on which a hunter tracks a target by smelling odors it emits. The odor intensity is supposed to be inversely proportional to the distance it propagates. The Monte Carlo simulation is performed on a 2-dimensional bond-percolation above the threshold. Having no idea of the location of the target, the hunter determines its moves only by random attempts in each direction. For lager percolation connectivity p (>~) 0.90, it reveals a scaling law for the searching time versus the distance to the position of the target. The scaling exponent is dependent on the sensitivity of the hunter. For smaller p, the scaling law is broken and the probability of finding out the target significantly reduces. The hunter seems trapped in the cluster of the percolation and can hardly reach the goal.