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Sample records for californium 250 target

  1. Magnetism in californium

    International Nuclear Information System (INIS)

    A SQUID-based magnetic susceptometer has been constructed for studying small radioactive samples at temperatures below 350 K and in magnetic fields up to 50 kilogauss. The device has been used to study californium (element 98) in a number of solid-state forms: the dhcp metal, several oxides (Cf2O3 in both the bcc and monoclinic structures, Cf7O12, CfO2 and BaCfO3), several monopnictides (CfN, CfAs and CfSb) and the trichloride (in both the hexagonal and orthorhombic structures). All of these materials were studied in polycrystalline form, and hexagonal CfCl3 was studied in single-crystal form as well. The susceptometer has the sensitivity to measure samples containing less than 10 micrograms of californium. The magnetic susceptibilities of all of the californium materials at temperatures above about 100 K are described well by the Curie-Weiss relationship. This behavior is consistent with the assumption that the magnetic 5f electrons are localized and that the paramagnetic behavior can be interpreted in terms of the properties of the free ion. The measured values of the effective paramagnetic moment, μ/sub eff/, for all the californium materials that were studied are reasonably consistent with theoretical values based on intermediate coupling models. All of the californium materials showed some indications of cooperative magnetic effects. The dhcp metal was observed to order ferromagnetically at 52 K, and all of the californium compounds studied showed signs of antiferromagnetic ordering, mostly at temperatures below 25 K. 91 refs., 50 figs., 19 tabs

  2. Californium Multiplier (CFX)

    International Nuclear Information System (INIS)

    The availability of 252Cf as an economical high-intensity neutron source has made it possible to construct compact neutron irradiation devices with widespread applications. The simplest such device consists of a single 252Cf source within a moderating and shielding medium. Higher neutron flux levels can be attained either through the use of more 252Cf or through source multiplication by means of a subcritical uranium assembly. Although the use of larger 252Cf sources to achieve higher neutron flux is technically straightforward, an economic penalty is paid as the source strength is increased. Larger californium sources imply larger initial investments to cover the cost of source material and larger operating costs resulting from the decay of the 252Cf source. A Californium Multiplier, the CFX, which produces a flux enhancement of 30 when compared to a conventional moderated 252Cf system has been designed, licensed, built, and tested by IRT Corporation. Such systems are now available on a commercial basis for both neutron radiography and neutron activation analysis. The first commercial CFX system was installed at the Research Laboratories of Eastman Kodak Company in Rochester, NY, in March 1975. This device, using 1 mg of 252Cf, is very stable and the neutron flux generated by the CFX is very reproducible. The performance characteristics of this system are summarized

  3. Californium--palladium metal neutron source material

    Science.gov (United States)

    Dahlen, B.L.; Mosly, W.C. Jr.; Smith, P.K.; Albenesius, E.L.

    1974-01-22

    Californium, as metal or oxide, is uniformly dispersed throughout a noble metal matrix, provided in compact, rod or wire form. A solution of californium values is added to palladium metal powder, dried, blended and pressed into a compact having a uni-form distribution of californium. The californium values are decomposed to californium oxide or metal by heating in an inert or reducing atmosphere. Sintering the compact to a high density closes the matrix around the dispersed californium. The sintered compact is then mechanically shaped into an elongated rod or wire form. (4 claims, no drawings) (Official Gazette)

  4. Californium Electrodepositions at Oak Ridge National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Boll, Rose Ann [ORNL

    2015-01-01

    Electrodepositions of californium isotopes were successfully performed at Oak Ridge National Laboratory (ORNL) during the past year involving two different types of deposition solutions, ammonium acetate (NH4C2H3O2) and isobutanol ((CH3)2CHCH2OH). A californium product that was decay enriched in 251Cf was recovered for use in super-heavy element (SHE) research. This neutron-rich isotope, 251Cf, provides target material for SHE research for the potential discovery of heavier isotopes of Z=118. The californium material was recovered from aged 252Cf neutron sources in storage at ORNL. These sources have decayed for over 30 years, thus providing material with a very high 251Cf-to-252Cf ratio. After the source capsules were opened, the californium was purified and then electrodeposited using the isobutanol method onto thin titanium foils for use in an accelerator at the Joint Institute for Nuclear Research in Dubna, Russia. Another deposition method, ammonium acetate, was used to produce a deposition containing 1.7 0.1 Ci of 252Cf onto a stainless steel substrate. This was the largest single electrodeposition of 252Cf ever prepared. The 252Cf material was initially purified using traditional ion exchange media, such as AG50-AHIB and AG50-HCl, and further purified using a TEVA-NH4SCN system to remove any lanthanides, resulting in the recovery of 3.6 0.1 mg of purified 252Cf. The ammonium acetate deposition was run with a current of 1.0 amp, resulting in a 91.5% deposition yield. Purification and handling of the highly radioactive californium material created additional challenges in the production of these sources.

  5. Californium-252 progress, report No. 7, April 1971

    Energy Technology Data Exchange (ETDEWEB)

    1971-12-31

    This report contains discusses of the following topics on Californium-252: First sales of californium-252; encapsulation services discussed; three new participants in market evaluation program; summer training programs to use californium; Californium-252 shipping casks available; Californium-252 questions and answers, radiotherapy; neutron radiography; natural resources exploration; nuclear safeguards; process control; dosimetry; neutron radiography; neutron shielding; and nuclear safeguards.

  6. Neutron production for 250 MeV protons bombarding on thick grain-made tungsten target

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xueying; Zhang, Yanbin; Ma, Fei; Ju, Yongqin; Chen, Liang; Wang, Jianguo; Ge, Honglin [Chinese Academy of Sciences, Institute of Modern Physics, Lanzhou (China); Zhang, Hongbin; Li, Yanyan; Wan, Bo [Chinese Academy of Sciences, Institute of Modern Physics, Lanzhou (China); University of Chinese Academy of Sciences, Beijing (China)

    2015-08-15

    Neutron yield for 250 MeV protons incident on a tungsten target has been measured using the water bath method. The target was made of many randomly placed tungsten grains. Through analyzing the activity of Au foils, the neutron flux distribution in water was obtained. The neutrons slowing down process shows that the neutrons from tungsten have an average energy lower than neutrons from the lead target. The neutron yield was experimentally determined to be 2.02 ± 0.15 neutron/proton. Detailed simulation was also performed with the Geant4 toolkit. Comparison has been made with the experimentally derived neutron yield. It was found that, around 250 MeV, experimental results were described satisfactorily with a combination of high-energy spallation, low-energy neutron reaction and scattering. It was shown that the grain-packed target does not affect much the main neutronic properties, which are of crucial importance for the design of the spallation target. (orig.)

  7. Historical Review of Californium-252 Discovery and Development

    Science.gov (United States)

    Stoddard, D. H.

    1985-01-01

    This paper discusses the discovery and history of californium 252. This isotope may be synthesized by irradiating plutonium 239, plutonium 242, americium 243, or curium 244 with neutrons in a nuclear reactor. Various experiments and inventions involving Cf conducted at the Savannah River Plant are discussed. The evolution of radiotherapy using californium 252 is reviewed. (PLG)

  8. Historical review of californium-252 discovery and development

    International Nuclear Information System (INIS)

    This paper discusses the discovery and history of californium 252. This isotope may be synthesized by irradiating plutonium 239, plutonium 242, americium 243, or curium 244 with neutrons in a nuclear reactor. Various experiments and inventions involving 252Cf conducted at the Savannah River Plant are discussed. The evolution of radiotherapy using californium 252 is reviewed

  9. Californium-252: a remarkable versatile radioisotope

    Energy Technology Data Exchange (ETDEWEB)

    Osborne-Lee, I.W.; Alexander, C.W.

    1995-10-10

    A product of the nuclear age, Californium-252 ({sup 252}Cf) has found many applications in medicine, scientific research, industry, and nuclear science education. Californium-252 is unique as a neutron source in that it provides a highly concentrated flux and extremely reliable neutron spectrum from a very small assembly. During the past 40 years, {sup 252}Cf has been applied with great success to cancer therapy, neutron radiography of objects ranging from flowers to entire aircraft, startup sources for nuclear reactors, fission activation for quality analysis of all commercial nuclear fuel, and many other beneficial uses, some of which are now ready for further growth. Californium-252 is produced in the High Flux Isotope Reactor (HFIR) and processed in the Radiochemical Engineering Development Center (REDC), both of which are located at the Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee. The REDC/HFIR facility is virtually the sole supplier of {sup 252}Cf in the western world and is the major supplier worldwide. Extensive exploitation of this product was made possible through the {sup 252}Cf Market Evaluation Program, sponsored by the United States Department of Energy (DOE) [then the Atomic Energy Commission (AEC) and later the Energy Research and Development Administration (ERDA)]. This program included training series, demonstration centers, seminars, and a liberal loan policy for fabricated sources. The Market Evaluation Program was instituted, in part, to determine if large-quantity production capability was required at the Savannah River Laboratory (SRL). Because of the nature of the product and the means by which it is produced, {sup 252}Cf can be produced only in government-owned facilities. It is evident at this time that the Oak Ridge research facility can meet present and projected near-term requirements. The production, shipment, and sales history of {sup 252}Cf from ORNL is summarized herein.

  10. Californium-252: a remarkable versatile radioisotope

    International Nuclear Information System (INIS)

    A product of the nuclear age, Californium-252 (252Cf) has found many applications in medicine, scientific research, industry, and nuclear science education. Californium-252 is unique as a neutron source in that it provides a highly concentrated flux and extremely reliable neutron spectrum from a very small assembly. During the past 40 years, 252Cf has been applied with great success to cancer therapy, neutron radiography of objects ranging from flowers to entire aircraft, startup sources for nuclear reactors, fission activation for quality analysis of all commercial nuclear fuel, and many other beneficial uses, some of which are now ready for further growth. Californium-252 is produced in the High Flux Isotope Reactor (HFIR) and processed in the Radiochemical Engineering Development Center (REDC), both of which are located at the Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee. The REDC/HFIR facility is virtually the sole supplier of 252Cf in the western world and is the major supplier worldwide. Extensive exploitation of this product was made possible through the 252Cf Market Evaluation Program, sponsored by the United States Department of Energy (DOE) [then the Atomic Energy Commission (AEC) and later the Energy Research and Development Administration (ERDA)]. This program included training series, demonstration centers, seminars, and a liberal loan policy for fabricated sources. The Market Evaluation Program was instituted, in part, to determine if large-quantity production capability was required at the Savannah River Laboratory (SRL). Because of the nature of the product and the means by which it is produced, 252Cf can be produced only in government-owned facilities. It is evident at this time that the Oak Ridge research facility can meet present and projected near-term requirements. The production, shipment, and sales history of 252Cf from ORNL is summarized herein

  11. Californium-252 Neutron Therapy in China

    International Nuclear Information System (INIS)

    Californium-252 brachytherapy, believed to be the most successful source for neutron therapy, gives most of the cures as well as long-term and complication-free survivals. Chinese radiation oncologists were interested in californium neutron therapy (Cf-NT) in the early 1980s, but 252Cf sources for medical use were not available in China until 1992 when a californium joint venture was established by the China Institute of Atomic Energy (Beijing) and the Research Institute for Nuclear Reactors (Dimitrovgrad) of Russia. In 1995, 25 seeds of 252Cf with a strength of 3 μg each were sent to China for preclinical investigation. Three years later, a high dose rate (HDR) 252Cf source was imported and transferred into a home-made remote after-loader for intracavitary treatment in Chongqing, and a clinical trail was started in February 1999. This is the first time that Cf-NT was performed for cancer patients in China. Since then, Cf-NT in China has developed rapidly. It is estimated that one-tenth of those radiation oncology centers with brachytherapy practice will be equipped with californium units in 5 yr. That means more than 30 units will be in use in hospitals. That is significant compared with other countries, but it is just one, on average, for each province or one per 40 million people in China. Progress also has been achieved in the 252Cf treatment delivery equipment. Preliminary clinical trails showed complete response observed in all cases treated, with a rapid clearance of tumors and mild reactions in normal tissues. The short-term results are quite encouraging. To deal with problems due to the demand for Cf-NT in China, attention should be paid to the following particulars: (1) A high-strength miniature source is needed for HDR/MDR interstitial therapy to extend the Cf-NT coverage. (2) Basic work on radiophysics and radiobiology needs to be done, including source calibration, clinical dosimetry, clinical RBE determination, and Cf-NT quality assurance

  12. Californium-252 sales and loans at Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    The production and distribution in the United States of 252Cf has recently been consolidated at the Oak Ridge National Laboratory (ORNL). The 252Cf Industrial Sales/Loan Program and the 252Cf University Load Program, which were formerly located at the Savannah River Plant (SRP), have been combined with the californium production and distribution activities of the Transuranium Element Production Program at ORNL. Californium-252 is sold to commercial users in the form of bulk californium oxide, palladium-californium alloy pellets, or alloy wires. Neutron source capsules, which are fabricated for loans to DOE or other US government agencies, are still available in all forms previously available. The consolidation of all 252Cf distribution activities at the production site is expected to result in better service to users. In particular, customers for neutrons sources will be ale to select from a wider range of neutron source forms, including custom designs, through a single contact point

  13. Spontaneous Partitioning of Californium from Curium: Curious Cases from the Crystallization of Curium Coordination Complexes

    Energy Technology Data Exchange (ETDEWEB)

    Cary, Samantha K.; Silver, Mark A.; Liu, Guokui; Wang, Jamie C.; Bogart, Justin A.; Stritzinger, Jared T.; Arico, Alexandra A.; Hanson, Kenneth; Schelter, Eric J.; Albrecht-Schmitt, Thomas E.

    2015-12-07

    The reaction of 248CmCl3 with excess 2,6-pyridinedicarboxylic acid (DPA) under mild solvothermal conditions results in crystallization of the tris-chelate complex Cm(HDPA)3·H2O. Approximately half of the curium remains in solution at the end of this process, and evaporation of the mother liquor results in crystallization of the bis-chelate complex [Cm(HDPA)- (H2DPA)(H2O)2Cl]Cl·2H2O. 248Cm is the daughter of the α decay of 252Cf and is extracted in high purity from this parent. However, trace amounts of 249,250,251Cf are still present in all samples of 248Cm. During the crystallization of Cm(HDPA)3·H2O and [Cm(HDPA)(H2DPA)(H2O)2Cl]Cl·2H2O, californium(III) spontaneously separates itself from the curium complexes and is found doped within crystals of DPA in the form of Cf(HDPA)3. These results add to the growing body of evidence that the chemistry of californium is fundamentally different from that of earlier actinides.

  14. Californium-252 encapsulation at the Savannah River Laboratory

    International Nuclear Information System (INIS)

    More than 1 g of the neutron-emitting isotope californium-252 has been encapsulated at SRL for worldwide medical, industrial, and research uses. Bulk sales packages have been prepared for the USDOE sales program since 1971. Doubly-encapsulated sources have been prepared for USDOE's market evaluation program since 1968. Californium-252 sources for loan and sales packages satisfy the criteria for Special Form Radioactive Material. Encapsulation is performed in special neutron-shielded containment facilities at SRL. Development of improved source and shipping package designs and processes is continuing. 17 figures

  15. Production, distribution and applications of californium-252 neutron sources

    International Nuclear Information System (INIS)

    The radioisotope 252Cf is routinely encapsulated into compact, portable, intense neutron sources with a 2.6-yr half-life. A source the size of a person's little finger can emit up to 1011 neutrons s-1. Californium-252 is used commercially as a reliable, cost-effective neutron source for prompt gamma neutron activation analysis (PGNAA) of coal, cement and minerals, as well as for detection and identification of explosives, land mines and unexploded military ordnance. Other uses are neutron radiography, nuclear waste assays, reactor start-up sources, calibration standards and cancer therapy. The inherent safety of source encapsulations is demonstrated by 30 yr of experience and by US Bureau of Mines tests of source survivability during explosions. The production and distribution center for the US Department of Energy (DOE) Californium Program is the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory (ORNL). DOE sells 252Cf to commercial reencapsulators domestically and internationally. Sealed 252Cf sources are also available for loan to agencies and subcontractors of the US government and to universities for educational, research and medical applications. The REDC has established the Californium User Facility (CUF) for Neutron Science to make its large inventory of 252Cf sources available to researchers for irradiations inside uncontaminated hot cells. Experiments at the CUF include a land mine detection system, neutron damage testing of solid-state detectors, irradiation of human cancer cells for boron neutron capture therapy experiments and irradiation of rice to induce genetic mutations

  16. Production, distribution and applications of californium-252 neutron sources.

    Science.gov (United States)

    Martin, R C; Knauer, J B; Balo, P A

    2000-01-01

    The radioisotope 252Cf is routinely encapsulated into compact, portable, intense neutron sources with a 2.6-yr half-life. A source the size of a person's little finger can emit up to 10(11) neutrons s(-1). Californium-252 is used commercially as a reliable, cost-effective neutron source for prompt gamma neutron activation analysis (PGNAA) of coal, cement and minerals, as well as for detection and identification of explosives, land mines and unexploded military ordinance. Other uses are neutron radiography, nuclear waste assays, reactor start-up sources, calibration standards and cancer therapy. The inherent safety of source encapsulations is demonstrated by 30 yr of experience and by US Bureau of Mines tests of source survivability during explosions. The production and distribution center for the US Department of Energy (DOE) Californium Program is the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory (ORNL). DOE sells 252Cf to commercial reencapsulators domestically and internationally. Sealed 252Cf sources are also available for loan to agencies and subcontractors of the US government and to universities for educational, research and medical applications. The REDC has established the Californium User Facility (CUF) for Neutron Science to make its large inventory of 252Cf sources available to researchers for irradiations inside uncontaminated hot cells. Experiments at the CUF include a land mine detection system, neutron damage testing of solid-state detectors, irradiation of human cancer cells for boron neutron capture therapy experiments and irradiation of rice to induce genetic mutations. PMID:11003521

  17. Production, Distribution, and Applications of Californium-252 Neutron Sources

    Energy Technology Data Exchange (ETDEWEB)

    Balo, P.A.; Knauer, J.B.; Martin, R.C.

    1999-10-03

    The radioisotope {sup 252}Cf is routinely encapsulated into compact, portable, intense neutron sources with a 2.6-year half-life. A source the size of a person's little finger can emit up to 10{sup 11} neutrons/s. Californium-252 is used commercially as a reliable, cost-effective neutron source for prompt gamma neutron activation analysis (PGNAA) of coal, cement, and minerals, as well as for detection and identification of explosives, laud mines, and unexploded military ordnance. Other uses are neutron radiography, nuclear waste assays, reactor start-up sources, calibration standards, and cancer therapy. The inherent safety of source encapsulations is demonstrated by 30 years of experience and by U.S. Bureau of Mines tests of source survivability during explosions. The production and distribution center for the U. S Department of Energy (DOE) Californium Program is the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory (ORNL). DOE sells The radioisotope {sup 252}Cf is routinely encapsulated into compact, portable, intense neutron sources with a 2.6- year half-life. A source the size of a person's little finger can emit up to 10 neutrons/s. Californium-252 is used commercially as a reliable, cost-effective neutron source for prompt gamma neutron activation analysis (PGNAA) of coal, cement, and minerals, as well as for detection and identification of explosives, laud mines, and unexploded military ordnance. Other uses are neutron radiography, nuclear waste assays, reactor start-up sources, calibration standards, and cancer therapy. The inherent safety of source encapsulations is demonstrated by 30 years of experience and by U.S. Bureau of Mines tests of source survivability during explosions. The production and distribution center for the U. S Department of Energy (DOE) Californium Program is the Radiochemical Engineering Development Center (REDC) at Oak Ridge National Laboratory(ORNL). DOE sells {sup 252}Cf to commercial

  18. Production of extra pure curium and californium preparations

    International Nuclear Information System (INIS)

    Preparations of curium-244,245,248 and californium-249,252 are used for the production of ionizing radiation sources for different applications and fundamental nuclear-physical investigations, placing high requirements on the radiochemical and chemical purity of the preparations. Extraction chromatography using di-(2-ethylhexyl)phosphoric acid (D2EHPA) as extractant was chosen to prepare extra pure curium and californium preparations. In order to identify the optimal conditions of Cm-Cf separation and to remove impurities from them (reagent and other impurities), investigations were performed into the effect of impurities (Na+, Ca2+, Al3+, Fe2+, Fe3+ taken as example), extractant and eluent concentration and solution flow rate on the efficiency of mutual purification of Cm and Cf. Both theoretical and experimental estimations were made of the maximum concentration at which the impurities do not affect the process. The conditions chosen allow mutual purification of milligram amounts of Cm and Cf from impurity elements at E(pur) =102 - 103 during a single chromatographic cycle (E(pur) =>103) using a column with 5 - 10 cm3 volume. In this case the production yield exceeds 98%. The purification of milligram amounts of curium and californium from fission products (lanthanides in general, cerium in particular) was performed in D2EHPA-decane-PbO2-HNO3 and D2EHPA-decane-DTPA-H3-Cit extraction chromatography systems. In order to establish the optimal conditions, the effect of [D2EHPA] and eluent on the mutual purification of Cm and Cf and on their purification from cerium and impurity elements was studied in the D2EHPA-decane-PbO2-HNO3 system. During a single chromatographic cycle the mutual purification factors of TPE and of their purification from impurity cations achieve 102-103, from cerium - E(pur) > 10. In the D2EHPA-decane-DTPA-H3Cit system, the effect of concentration of extractant and eluent pH on the efficiency of Cm and Cf purification from lanthanides was

  19. Production of new superheavy Z=108-114 nuclei with $^{238}$U, $^{244}$Pu and $^{248,250}$Cm targets

    CERN Document Server

    Feng, Zhao-Qing; Li, Jun-Qing

    2009-01-01

    Within the framework of the dinuclear system (DNS) model, production cross sections of new superheavy nuclei with charged numbers Z=108-114 are analyzed systematically. Possible combinations based on the actinide nuclides $^{238}$U, $^{244}$Pu and $^{248,250}$Cm with the optimal excitation energies and evaporation channels are pointed out to synthesize new isotopes which lie between the nuclides produced in the cold fusion and the $^{48}$Ca induced fusion reactions experimentally, which are feasible to be constructed experimentally. It is found that the production cross sections of superheavy nuclei decrease drastically with the charged numbers of compound nuclei. Larger mass asymmetries of the entrance channels enhance the cross sections in 2n-5n channels.

  20. Prompt neutron spectrum of the spontaneous fission of californium-252

    International Nuclear Information System (INIS)

    The californium-252 spontaneous fission neutron spectrum was measured in the energy range of 0.01 to 10 MeV by the time-of-flight technique using various neutron detectors. The measurements of 252Cf neutron spectrum at energies of 0.01 to 5 MeV were performed as a function of fission fragment kinetic energy. The mean neutron spectrum energy in the range of 0.7 to 10 MeV was found from the results of measurements. The irregularity in the 252Cf neutron spectrum in the neutron energy range of less than 0.7 MeV compared to theoretical values is discussed. The mechanism of 252Cf neutron emission is also discussed on the basis of neutron yield angle measurements. 12 references

  1. Separation of californium from actinides and lanthanides in aqueous solution by electrochemical formation of amalgams

    International Nuclear Information System (INIS)

    The electrochemical reduction of transneptunium elements (Pu to Cf) and rare earths (Eu, Tm) from aqueous complexing solutions to amalgams was studied over a wide range of cathodic potentials in order to achieve optimal separation of californium. The reduction in acetate media (pH 4.5-4.6) at potentials around -1.7 to -1.9 V1 leads to a quantitative extraction of californium into the mercury phase, while more negative potentials are required for the reduction of the lighter transuranium elements and of the lanthanides. Hence, the optimal conditions for the separation of californium from the investigated actinides and lanthanides were determined. Separation factors α between 25 and 90 were found except in the case of Cf/Eu, where poor values (α varying from 7 to 12) were observed. More negative cathodic potentials decrease the selectivity of the reduction process. A similar study with lithium citrate solutions (pH ∝6) shows that satisfactory separation of californium from lighter and heavier actinides is achievable. A separation factor of 88 is obtained for Cf/Am at -1.98 V. The anodic stripping of mixed amalgams (Pu, Am, Cm, Bk, Tm and Cf) Hg in nitric and acetic acid soultions at potentials ranging from +0.1 to -0.7 V proceeds slowly and proved to be ineffective for the separation of californium from light actinides under conditions described. (orig.)

  2. Biomedical neutron research at the Californium User Facility for neutron science

    International Nuclear Information System (INIS)

    The Californium User Facility for Neutron Science has been established at Oak Ridge National Laboratory (ORNL). The Californium User Facility (CUF) is a part of the larger Californium Facility, which fabricates and stores compact 252Cf neutron sources for worldwide distribution. The CUF can provide a cost-effective option for research with 252Cf sources. Three projects at the CUF that demonstrate the versatility of 252Cf for biological and biomedical neutron-based research are described: future establishment of a 252Cf-based neutron activation analysis system, ongoing work to produce miniature high-intensity, remotely afterloaded 252Cf sources for tumor therapy, and a recent experiment that irradiated living human lung cancer cells impregnated with experimental boron compounds to test their effectiveness for boron neutron capture therapy

  3. Biomedical neutron research at the Californium User Facility for neutron science

    Energy Technology Data Exchange (ETDEWEB)

    Martin, R.C. [Oak Ridge National Lab., TN (United States); Byrne, T.E. [Roane State Community College, Harriman, TN (United States); Miller, L.F. [Univ. of Tennessee, Knoxville, TN (United States)

    1997-04-01

    The Californium User Facility for Neutron Science has been established at Oak Ridge National Laboratory (ORNL). The Californium User Facility (CUF) is a part of the larger Californium Facility, which fabricates and stores compact {sup 252}Cf neutron sources for worldwide distribution. The CUF can provide a cost-effective option for research with {sup 252}Cf sources. Three projects at the CUF that demonstrate the versatility of {sup 252}Cf for biological and biomedical neutron-based research are described: future establishment of a {sup 252}Cf-based neutron activation analysis system, ongoing work to produce miniature high-intensity, remotely afterloaded {sup 252}Cf sources for tumor therapy, and a recent experiment that irradiated living human lung cancer cells impregnated with experimental boron compounds to test their effectiveness for boron neutron capture therapy.

  4. Emergence of californium as the second transitional element in the actinide series.

    Science.gov (United States)

    Cary, Samantha K; Vasiliu, Monica; Baumbach, Ryan E; Stritzinger, Jared T; Green, Thomas D; Diefenbach, Kariem; Cross, Justin N; Knappenberger, Kenneth L; Liu, Guokui; Silver, Mark A; DePrince, A Eugene; Polinski, Matthew J; Van Cleve, Shelley M; House, Jane H; Kikugawa, Naoki; Gallagher, Andrew; Arico, Alexandra A; Dixon, David A; Albrecht-Schmitt, Thomas E

    2015-01-01

    A break in periodicity occurs in the actinide series between plutonium and americium as the result of the localization of 5f electrons. The subsequent chemistry of later actinides is thought to closely parallel lanthanides in that bonding is expected to be ionic and complexation should not substantially alter the electronic structure of the metal ions. Here we demonstrate that ligation of californium(III) by a pyridine derivative results in significant deviations in the properties of the resultant complex with respect to that predicted for the free ion. We expand on this by characterizing the americium and curium analogues for comparison, and show that these pronounced effects result from a second transition in periodicity in the actinide series that occurs, in part, because of the stabilization of the divalent oxidation state. The metastability of californium(II) is responsible for many of the unusual properties of californium including the green photoluminescence. PMID:25880116

  5. ACC 250 Tutorials / acc250dotcom

    OpenAIRE

    modumteja

    2015-01-01

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  6. Fissile analysis of Hanford waste using Californium Multiplier/Delayed Neutron Counter system

    International Nuclear Information System (INIS)

    Measurement of low-level (10 ng/g or lower) fissile material (mainly plutonium) in Hanford waste and process samples is becoming increasingly important. A system has been designed consisting of a Californium Multiplier (CFX) and a Delayed Neutron Counter (DNC) to characterize these samples. This report describes hardware and analytical capability of the CFX/DNC system

  7. Emergence of californium as the second transitional element in the actinide series

    OpenAIRE

    Cary, Samantha K.; Vasiliu, Monica; Baumbach, Ryan E.; Stritzinger, Jared T.; GREEN, THOMAS D.; Diefenbach, Kariem; Cross, Justin N.; Knappenberger, Kenneth L.; Liu, Guokui; Silver, Mark A.; DePrince, A. Eugene; Polinski, Matthew J.; Van Cleve, Shelley M.; House, Jane H.; Kikugawa, Naoki

    2015-01-01

    A break in periodicity occurs in the actinide series between plutonium and americium as the result of the localization of 5f electrons. The subsequent chemistry of later actinides is thought to closely parallel lanthanides in that bonding is expected to be ionic and complexation should not substantially alter the electronic structure of the metal ions. Here we demonstrate that ligation of californium(III) by a pyridine derivative results in significant deviations in the properties of the resu...

  8. Charge state and incident energy dependence of K X-ray emission as a function of target thickness for 50-165 MeV Cu ions incident on 11-250 μg/cm 2 Cu

    Science.gov (United States)

    Momoi, T.; Shima, K.; Umetani, K.; Moriyama, M.; Ishihara, T.; Mikumo, T.

    1986-05-01

    Thin self-supporting Cu targets in 11-250 μg/cm 2 thickness were bombarded with 50-165 MeV Cu qi+ ions (7 ⩽ qi⩽ 24) to investigate the target thickness dependence of inner shell vacancy production processes in the symmetric collision of Cu + Cu. Doppler-shifted projectile K X-rays were discriminated from the target K X-rays, and the projectile and target K X-ray yields were separately measured as a function of target thickness. The K X-ray yields emitted from the projectile and the target Cu atoms are strongly dependent on the projectile initial charge state and target thickness for all the investigated collision systems of Cu qi+ + Cu. From the observed K X-ray yields, K-shell vacancy production cross sections averaged over the target thickness t of projectile overlineσ KV and target overlineσ ∗KV were separately derived taking into account the fluorescence yield that can be estimated from the Kα X-ray energy shift. When the values of overlineσ KV and overlineσ ∗KV are extrapolated to zero foil thickness, the K shell vacancy formed in the collision has been found to be equally shared between projectile and target in a single collision. With the increase of penetration depth, however, the values of overlineσ ∗KV are greater than those of overlineσ KV presumably due to electron transfer of a target K electron to the projectile K vacancy. the evolution process of projectile excited states as a function of target thickness and the resulting variation of projectile and target K X-ray emissions are discussed.

  9. Manganese determination om minerals by activation analysis, using the californium-252 as a neutron source

    International Nuclear Information System (INIS)

    Neutron Activation Analysis, using a Californium-252 neutron source, has been applied for the determination of manganese in ores such as pyrolusite, rodonite (manganese silicate)' and blending used in dry-batteries The favorable nuclear properties of manganese, such as high thermal neutron cross-section for the reaction 55Mn (n.gamma)56 Mn, high concentration of manganese in the matrix and short half - life of 56Mn, are an ideal combination for non-destructive analysis of manganese in ores. Samples and standards of manganese dioxide were irradiated for about 20 minutes, followed by a 4 to 15 minutes decay and counted in a single channel pulse-height discrimination using a NaI(Tl) scintillation detector. Counting time was equal to 10 minutes. The interference of nuclear reactions 56Fe(n,p)56Mn and 59 Co (n, α)56 were studied, as well as problems in connection with neutron shadowing during irradiation, gamma-rays attenuation during counting and influence of granulometry of samples. One sample,was also analysed by wet-chemical method (sodium bismuthate) in order to compare results. As a whole, i t was shown that the analytical method of neutron activation for manganese in ores and blending, is a method simple, rapid and with good precision and accuracy. (author)

  10. Long-term effects of an intracavitary treatment with californium-252 on normal tissue

    International Nuclear Information System (INIS)

    About one hundred fifty swine were exposed to either radium-226 or californium-252 sources in the uterine cervix to determine an RBE for both acute and long-term effects. That value for early changes in the tissues at risk in the treatment of cervical cancer was between 6.2 and 6.8. The incidence of complications increased with time after exposure, especially among animals treated with 252Cf. Analysis of rectal injury showed that ulceration occurred frequently within a year postexposure at doses between 1600 and 2400 rad calculated at 2 cm lateral to the source midline. Fat necrosis and smooth muscle atrophy, resulting in a local rectal stricture, were delayed changes observed in some animals. The lower ureter was the site for a greater frequency of complications than the GI tract. Ureteral stricture often occurred at doses of 1200 rad from 252Cf and 7000 rad from 226Ra. Observation of delayed effects in the uterine-cervix in animals held up to 4 years postexposure indicate that the RBE for 252Cf may be increased to a value as high as 18, while repair may have even decreased it to about 5.6 in the rectum. Fifty swine are still being observed for long-term effects after doses above 800 rad from 252Cf and 5000 rad from 226Ra

  11. ACC 250 UOP Tutorial / Uoptutorial

    OpenAIRE

    Ben K. Green

    2015-01-01

    For more course tutorials visit www.uoptutorial.com   ACC 250 Week 1 CheckPoint Choosing Accounting Software ACC 250 Week 1 Assignment Accounting Software Memo ACC 250 Week 2 CheckPoint Bellwether Garden Supply Back Up and Restore Data ACC 250 Week 2 DQ 1 and DQ 2 ACC 250 Week 3 CheckPoint Bellwether Garden Supply Vendor Transactions ACC 250 Week 3 Assignment Bellwether Garden Supply Record a Transaction ACC 250 Week 4 CheckPoint Bellwether Garden Supp...

  12. ACC 250 UOP Courses / uoptutorial

    OpenAIRE

    hani

    2015-01-01

    For more course tutorials visit www.uoptutorial.com     ACC 250 Week 1 CheckPoint Choosing Accounting Software ACC 250 Week 1 Assignment Accounting Software Memo ACC 250 Week 2 CheckPoint Bellwether Garden Supply Back Up and Restore Data ACC 250 Week 2 DQ 1 and DQ 2 ACC 250 Week 3 CheckPoint Bellwether Garden Supply Vendor Transactions ACC 250 Week 3 Assignment Bellwether Garden Supply Record a Transaction ACC 250 Week 4 CheckPoint Bellwether...

  13. ACC 250 UOP TUTORIAL / Uoptutorial

    OpenAIRE

    Cherry

    2015-01-01

    For more course tutorials visit www.uoptutorial.com   ACC 250 Week 1 CheckPoint Choosing Accounting Software ACC 250 Week 1 Assignment Accounting Software Memo ACC 250 Week 2 CheckPoint Bellwether Garden Supply Back Up and Restore Data ACC 250 Week 2 DQ 1 and DQ 2 ACC 250 Week 3 CheckPoint Bellwether Garden Supply Vendor Transactions ACC 250 Week 3 Assignment Bellwether Garden Supply Record a Transaction ACC 250 Week 4 CheckPoint Bellwether Garden Sup...

  14. Application of TSH bioindicator for studying the biological efficiency of neutrons from californium-252 source

    Energy Technology Data Exchange (ETDEWEB)

    Cebulska-Wasilewska, A.; Rekas, K. [Institute of Nuclear Physics, Cracow (Poland); Kim, J.K. [Korea Atomic Energy Research Inst., Taejon (Korea, Republic of)

    1997-12-31

    The effectiveness of neutrons from a Californium-252 source in the induction of various abnormalities in the Tradescantia clone 4430 stamen hair cells (TSH-assay) was studied. The special attention was paid to check whether any enhancement in effects caused by process of boron neutron capture is visible in the cells enriched with boron ions. Two chemicals (borax and BSH) were applied to introduce boron-10 ions into cells. Inflorescence, normal or pretreated with chemicals containing boron, were irradiated in the air with neutrons from a Cf-252 source at KAERI, Taejon, Korea. To estimate the relative biological effectiveness (RBE) in the induction of gene mutations of the neutron beam under the study, Tradescantia inflorescences, without any chemical pretreatment, were irradiated with various doses of X-rays. The ranges of radiation doses used were 0-0.1 Gy in neutrons and 0-0.5 Gy in X-rays. After the time needed to complete the postirradiation repair Tradescantia cuttings were transferred to Cracow, where screening of gene and lethal; mutations, cell cycle alterations in somatic cells have been done, and dose response relationships were figured. The maximal RBE values were estimated in the range of 4.6-6.8. Alterations of RBE value were observed; from 6.8 to 7.8 in the case of plants pretreated with 240 ppm of B-10 from borax, and 4.6 to 6.1 in the case of 400 ppm of B-10 from BSH. Results showed a slight, although statistically insignificant increase in biological efficacy of radiation from the Cf-252 source in samples pretreated with boron containing chemicals. (author)

  15. Application of TSH bioindicator for studying the biological efficiency of neutrons from californium-252 source

    International Nuclear Information System (INIS)

    The effectiveness of neutrons from a Californium-252 source in the induction of various abnormalities in the Tradescantia clone 4430 stamen hair cells (TSH-assay) was studied. The special attention was paid to check whether any enhancement in effects caused by process of boron neutron capture is visible in the cells enriched with boron ions. Two chemicals (borax and BSH) were applied to introduce boron-10 ions into cells. Inflorescence, normal or pretreated with chemicals containing boron, were irradiated in the air with neutrons from a Cf-252 source at KAERI, Taejon, Korea. To estimate the relative biological effectiveness (RBE) in the induction of gene mutations of the neutron beam under the study, Tradescantia inflorescences, without any chemical pretreatment, were irradiated with various doses of X-rays. The ranges of radiation doses used were 0-0.1 Gy in neutrons and 0-0.5 Gy in X-rays. After the time needed to complete the postirradiation repair Tradescantia cuttings were transferred to Cracow, where screening of gene and lethal; mutations, cell cycle alterations in somatic cells have been done, and dose response relationships were figured. The maximal RBE values were estimated in the range of 4.6-6.8. Alterations of RBE value were observed; from 6.8 to 7.8 in the case of plants pretreated with 240 ppm of B-10 from borax, and 4.6 to 6.1 in the case of 400 ppm of B-10 from BSH. Results showed a slight, although statistically insignificant increase in biological efficacy of radiation from the Cf-252 source in samples pretreated with boron containing chemicals. (author)

  16. Oxygen enhancement ratio (OER) and therapeutic gain factor (GF) for californium-252 at low dose rate

    International Nuclear Information System (INIS)

    The potential benefit of the introduction of californium-252 in interstitial and intracavitary therapy is related to the greater efficiency of its neutron emission against anoxic cancer cells. In that respect, the oxygen enhancement ratio (OER) of the 252Cf emission has been determined for a continuous low dose rate irradiation. The biological system is growth inhibition in Vicia faba bean roots. A new Vicia faba ''BelB'' strain has been used, which better tolerates long periods (up to about 10 hours) of anoxia. In a first series of experiments, for a 252Cf (Dsub(n+γ)) dose rate of 0.11 Gy.h-1, an OER of 1.4+-0.1 was observed (the γ contribution Dγ to the total absorbed dose Dsub(n+γ) was 0.35 at the position of the root tips). In a second series of experiments, in somewhat different geometrical conditions with a 252Cf (Dsub(n+γ)) dose rate of 0.13 Gy.h-1, an OER of 1.5+-0.1 was observed (Dγ/Dsub(n+γ)=0.42). The OER values observed for similar irradiation times, with iridium-192 γ-rays, were 2.3+-0.2 and 2.6+-0.1 respectively, which leads to therapeutic gain factors (GF) of 1.6 and 1.7 respectively. These GF values are slightly lower than those previously obtained (GF=1.8) on the same system, with d(50)-Be p(75)-Be and 15 MeV neutron beams

  17. Clinical Report on Californium-252 Neutron Intraluminal Brachytherapy Combined with External Irradiation for Cervical Carcinoma Treatment

    Institute of Scientific and Technical Information of China (English)

    Huanyu Zhao; Keming Wang; Jian Sun; Xin Geng; Weiming Zhang

    2006-01-01

    OBJECTIVE To observe the curative effects and complications of californium-252 (252Cf) neutron intraluminal brachytherapy (IBT) combined with external irradiation (El) for treatment of cervical carcinoma.METHODS From December 2000 to December 2004, 128 cases of cervical carcinoma staged into ⅡA~ⅢB according to the International Federation of Gynecology and Obstetrics (FIGO) standards were treated with 252Cf neutron IBT using 8~10 Gy per fraction, once a week. The total dose at reference A point was 36~40 Gy in 4~5 fractions. From the second day after 252Cf neutron IBT treatment, the whole pelvic cavity was treated with 60Co γ-ray El, applying 2 Gy per fraction, 4 times per week. After 20~25 Gy of El, the center of the whole pelvic field was blocked with 4 cm of lead in width. The total dose of El was 45~50 Gy.RESULTS The short-term therapeutic effects were CR 95.3% and PR 4.7%. The 3 and 5-year local control rates were 93.5% and 87.9%. The overall 3-year survival rate was 87.5% and for Stages Ⅱ and Ⅲ , 90.9%and 81.5% respectively; the overall 5-year survival rate was 70% and for Stages Ⅱ and Ⅲ, 76.2% and 61% respectively. The rate of radiation complications was 4.7% for radiation cystitis, 7.8% for radiation proctitis, 6.3%for vagina contracture and adhesion and 5.5% for protracted radiation proctitis.CONCLUSION An combination of 252Cf neutron IBT with El for treatment of cervical carcinoma can be well-tolerated by cervical carcinoma patients. The rate of local tumor control is high and radiation complications are few.

  18. Divalent and trivalent gas-phase coordination complexes of californium: evaluating the stability of Cf(ii).

    Science.gov (United States)

    Dau, Phuong D; Shuh, David K; Sturzbecher-Hoehne, Manuel; Abergel, Rebecca J; Gibson, John K

    2016-08-01

    The divalent oxidation state is increasingly stable relative to the trivalent state for the later actinide elements, with californium the first actinide to exhibit divalent chemistry under moderate conditions. Although there is evidence for divalent Cf in solution and solid compounds, there are no reports of discrete complexes in which Cf(II) is coordinated by anionic ligands. Described here is the divalent Cf methanesulfinate coordination complex, Cf(II)(CH3SO2)3(-), prepared in the gas phase by reductive elimination of CH3SO2 from Cf(III)(CH3SO2)4(-). Comparison with synthesis of the corresponding Sm and Cm complexes reveals reduction of Cf(III) and Sm(III), and no evidence for reduction of Cm(III). This reflects the comparative 3+/2+ reduction potentials: Cf(3+) (-1.60 V) ≈ Sm(3+) (-1.55 V) ≫ Cm(3+) (-3.7 V). Association of O2 to the divalent complexes is attributed to formation of superoxides, with recovery of the trivalent oxidation state. The new gas-phase chemistry of californium, now the heaviest element to have been studied in this manner, provides evidence for Cf(II) coordination complexes and similar chemistry of Cf and Sm. PMID:27424652

  19. Solving the Hydration Structure of the Heaviest Actinide Aqua Ion Known: The Californium(III) Case

    Energy Technology Data Exchange (ETDEWEB)

    Den Auwer, Ch.; Guillaumont, D. [CEA Marcoule, Nucl Energy Div, Radiochem Proc Dept, SCPS LILA, 30 (France); Galbis, E.; Pappalardo, Rafael R.; Marcos Sanchez, E. [Univ Seville, Dept Quim Fis, E-41012 Seville (Spain); Hernandez-Cobos, J. [Inst Ciencias Fis, Cuernavaca 62251, Morelos (Mexico); Le Naour, C.; Simoni, E. [Univ Paris Sud, Inst Phys Nucl Orsay, Paris (France)

    2010-07-01

    In summary, the first MC simulation of the trivalent cation of californium, based on an exchangeable hydrated ion-water intermolecular potential, has been shown to extend and improve the hydrated ion model. Likewise, the CfL{sub III}-edge EXAFS spectrum of an acidic 1 mm Cf(ClO{sub 4}){sub 3} aqueous solution recorded under optimized experimental conditions has greatly improved the signal/noise ratio of the only previously recorded spectrum. The comparison of the experimental EXAFS spectrum with the two computed ones, obtained from two different intermolecular potentials that predict eight (BP86) or nine (MP2) water molecules in the first coordination shell, leads to the conclusion that the lowest hydration number is preferred. Then, as Cf{sup III} is the heaviest actinide aqua ion for which there is experimental information, the actinide contraction is supported by the present study. (For U{sup III}, R{sub U-O}=2.56 Angstroms, and CN=9{+-}1; for Pu{sup III}, R{sub Pu-O}=2.51 Angstroms and CN=9{+-}1; for Cm{sup III}, R{sub Cm-O}=2.47 Angstroms and CN=9{+-}1). The role of the second hydration shell is important in defining the structure and dynamics of the Cf{sup III} aqua ion, but the contribution of second-shell water molecules to the EXAFS signal as back-scatters is marginal. Finally, this work gives an illustrative example of the benefits which can be achieved from the combination of experimental X-ray absorption spectroscopy and computer simulations. The usefulness of the simultaneous analysis of the results as well as the importance of the structural statistical average has been clearly demonstrated herein. Each technique independently was not adequate. We believe that this study traces out a still poorly explored combined methodology which may be extremely useful for many other complexes and chemical problems. A systematic theoretical and experimental examination of the other known actinide cations on the same basis should be undertaken to confirm the

  20. From ANAIS-25 towards ANAIS-250

    CERN Document Server

    Amaré, J; Cuesta, C; García, E; Ginestra, C; Martínez, M; Oliván, M A; Ortigoza, Y; de Solórzano, A Ortiz; Pobes, C; Puimedón, J; Sarsa, M L; Villar, J A; Villar, P

    2014-01-01

    The ANAIS (Annual modulation with NaI(Tl) Scintillators) experiment aims at the confirmation of the DAMA/LIBRA signal using the same target and technique at the Canfranc Underground Laboratory (LSC). 250 kg of ultra pure NaI(Tl) crystals will be used as target, divided into 20 modules, 12.5 kg mass each, and coupled to two high e?ciency photomultiplier tubes from Hamamatsu. The ANAIS-25 set-up at the LSC consists of two prototypes, amounting 25 kg NaI(Tl), grown from a powder having a potassium level under the limit of our analytical techniques, and installed in a convenient shielding at the LSC. The background has been carefully analyzed and main results will be summarized in this paper, focusing on the alpha contamination identified in the prototypes and the related background contributions. Status of fulfillment of ANAIS experimental goals and prospects for the building of ANAIS-250 experiment will be also revised.

  1. HTT 250 UOP Coureses/UOP Help

    OpenAIRE

    royal8

    2015-01-01

    HTT 250 Entire Course For more course tutorials visit www.uophelp.com     HTT 250 Week 1 Assignment: Organization Chart Hotel Front Office HTT 250 Week 1 CheckPoint: Total Quality Management HTT 250 Week 1 CheckPoint: Lodging Properties HTT 250 Week 2 CheckPoint: Hotel Price Comparison HTT 250 Week 2 DQs HTT 250 Week 3 CheckPoint: Average Daily Rate HTT 250 Week 4 CheckPoint: Front Office FAQs HTT 250 Week 4 DQs HTT 250 Week 5 Assi...

  2. ACC 250 UOP Tutorial/Uoptutorial

    OpenAIRE

    Giselle Isabel

    2015-01-01

    ACC 250 Week 1 CheckPoint Choosing Accounting Software ACC 250 Week 1 Assignment Accounting Software Memo ACC 250 Week 2 CheckPoint Bellwether Garden Supply Back Up and Restore Data ACC 250 Week 2 DQ 1 and DQ 2 ACC 250 Week 3 CheckPoint Bellwether Garden Supply Vendor Transactions ACC 250 Week 3 Assignment Bellwether Garden Supply Record a Transaction ACC 250 Week 4 CheckPoint Bellwether Garden Supply Payroll ACC 250 Week 4 DQ 1 and DQ 2 ACC 250 Week 5 CheckPoi...

  3. Development of electron beam ion source charge breeder for rare isotopes at Californium Rare Isotope Breeder Upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Kondrashev, S.; Dickerson, C.; Levand, A.; Ostroumov, P. N.; Pardo, R. C.; Savard, G.; Vondrasek, R. [Physics Division, Argonne National Laboratory, Argonne, Illinois 60439 (United States); Alessi, J.; Beebe, E.; Pikin, A. [Collider-Accelerator Department, Brookhaven National Laboratory, Upton, New York 11973 (United States); Kuznetsov, G. I.; Batazova, M. A. [Budker Institute of Nuclear Physics, Novosibirsk 630090 (Russian Federation)

    2012-02-15

    Recently, the Californium Rare Isotope Breeder Upgrade (CARIBU) to the Argonne Tandem Linac Accelerator System (ATLAS) was commissioned and became available for production of rare isotopes. Currently, an electron cyclotron resonance ion source is used as a charge breeder for CARIBU beams. To further increase the intensity and improve the purity of neutron-rich ion beams accelerated by ATLAS, we are developing a high-efficiency charge breeder for CARIBU based on an electron beam ion source (EBIS). The CARIBU EBIS charge breeder will utilize the state-of-the-art EBIS technology recently developed at Brookhaven National Laboratory (BNL). The electron beam current density in the CARIBU EBIS trap will be significantly higher than that in existing operational charge-state breeders based on the EBIS concept. The design of the CARIBU EBIS charge breeder is nearly complete. Long-lead components of the EBIS such as a 6-T superconducting solenoid and an electron gun have been ordered with the delivery schedule in the fall of 2011. Measurements of expected breeding efficiency using the BNL Test EBIS have been performed using a Cs{sup +} surface ionization ion source for external injection in pulsed mode. In these experiments we have achieved {approx}70% injection/extraction efficiency and breeding efficiency into the most abundant charge state of {approx}17%.

  4. Development of electron beam ion source charge breeder for rare isotopes at Californium Rare Isotope Breeder Upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Kondrashev S.; Alessi J.; Dickerson, C.; Levand, A.; Ostroumov, P.N.; Pardo, R.C.; Savard, G.; Vondrasek, R.; Beebe, E.; Pikin, A.; Kuznetsov, G.I.; Batazova, M.A.

    2012-02-03

    Recently, the Californium Rare Isotope Breeder Upgrade (CARIBU) to the Argonne Tandem Linac Accelerator System (ATLAS) was commissioned and became available for production of rare isotopes. Currently, an electron cyclotron resonance ion source is used as a charge breeder for CARIBU beams. To further increase the intensity and improve the purity of neutron-rich ion beams accelerated by ATLAS, we are developing a high-efficiency charge breeder for CARIBU based on an electron beam ion source (EBIS). The CARIBU EBIS charge breeder will utilize the state-of-the-art EBIS technology recently developed at Brookhaven National Laboratory (BNL). The electron beam current density in the CARIBU EBIS trap will be significantly higher than that in existing operational charge-state breeders based on the EBIS concept. The design of the CARIBU EBIS charge breeder is nearly complete. Long-lead components of the EBIS such as a 6-T superconducting solenoid and an electron gun have been ordered with the delivery schedule in the fall of 2011. Measurements of expected breeding efficiency using the BNL Test EBIS have been performed using a Cs{sup +} surface ionization ion source for external injection in pulsed mode. In these experiments we have achieved {approx}70% injection/extraction efficiency and breeding efficiency into the most abundant charge state of {approx}17%.

  5. Long-term effects of an intracavitary treatment with californium-252 on normal tissue. [Swine, /sup 226/Ra

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, M.F.; Beamer, J.L.; Mahony, T.D.; Cross, F.T.; Lund, J.E.; Endres, G.W.R.

    1976-01-01

    About one hundred fifty swine were exposed to either radium-226 or californium-252 sources in the uterine cervix to determine an RBE for both acute and long-term effects. That value for early changes in the tissues at risk in the treatment of cervical cancer was between 6.2 and 6.8. The incidence of complications increased with time after exposure, especially among animals treated with /sup 252/Cf. Analysis of rectal injury showed that ulceration occurred frequently within a year postexposure at doses between 1600 and 2400 rad calculated at 2 cm lateral to the source midline. Fat necrosis and smooth muscle atrophy, resulting in a local rectal stricture, were delayed changes observed in some animals. The lower ureter was the site for a greater frequency of complications than the GI tract. Ureteral stricture often occurred at doses of 1200 rad from /sup 252/Cf and 7000 rad from /sup 226/Ra. Observation of delayed effects in the uterine-cervix in animals held up to 4 years postexposure indicate that the RBE for /sup 252/Cf may be increased to a value as high as 18, while repair may have even decreased it to about 5.6 in the rectum. Fifty swine are still being observed for long-term effects after doses above 800 rad from /sup 252/Cf and 5000 rad from /sup 226/Ra.

  6. Preparation of actinide targets by electrodeposition

    Science.gov (United States)

    Trautmann, N.; Folger, H.

    1989-10-01

    Actinide targets with varying thicknesses on different substrates have been prepared by electrodeposition either from aqueous solutions or from solutions of their nitrates in isopropyl alcohol. With these techniques the actinides can be deposited almost quantitatively on various backing materials within 15 to 30 min. Targets of thorium, uranium, neptunium, plutonium, americium, curium and californium with areal densities from almost carrier-free up to 1.4 mg/cm 2 on thin beryllium, carbon, titanium, tantalum and platinum foils have been prepared. In most cases, prior to the deposition, the actinides had to be purified chemically and for some of them, due to the limited amount of material available, recycling procedures were required. Applications of actinide targets in heavy-ion reactions are briefly discussed.

  7. ACC 250 UOP COURSE TUTORIAL/ UOPHELP

    OpenAIRE

    veeru1

    2015-01-01

    For more course tutorials visit www.uophelp.com   ACC 250 Week 1 CheckPoint Choosing Accounting Software ACC 250 Week 1 Assignment Accounting Software Memo ACC 250 Week 2 CheckPoint Bellwether Garden Supply Back Up and Restore Data ACC 250 Week 2 DQ 1 and DQ 2 ACC 250 Week 3 CheckPoint Bellwether Garden Supply Vendor Transactions ACC 250 Week 3 Assignment Bellwether Garden Supply Record a Transaction ACC 250 Week 4 CheckPoint Bellwether Garden Supply P...

  8. 48 CFR 1846.673 - Distribution of DD Forms 250 and 250c.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Distribution of DD Forms... Reports 1846.673 Distribution of DD Forms 250 and 250c. (a) DD Forms 250 and 250c shall be distributed in accordance with installation procedures. (b) The contractor is responsible for distributing DD Forms 250...

  9. Ab initio full-potential study of mechanical properties and magnetic phase stability of californium monopnictides (CfN and CfP)

    Science.gov (United States)

    Amari, S.; Bouhafs, B.

    2016-09-01

    Based on the first-principles methods, the structural, elastic, electronic, properties and magnetic ordering of californium monopnictides CfX (X = P) have been studied using the full-potential augmented plane wave plus local orbitals (FP-L/APW + lo) method within the framework of density functional theory (DFT). The electronic exchange correlation energy is described by generalized gradient approximation GGA and GGA+U (U is the Hubbard correction). The GGA+U method is applied to the rare-earth 5f states. We have calculated the lattice parameters, bulk modulii and the first pressure derivatives of the bulk modulii. The elastic properties of the studied compounds are only investigated in the most stable calculated phase. In order to gain further information, we have calculated Young's modulus, shear modulus, anisotropy factor and Kleinman parameter by the aid of the calculated elastic constants. The results mainly show that californium monopnictides CfX (X = P) have an antiferromagnetic spin ordering. Density of states (DOS) and charge densities for both compounds are also computed in the NaCl (B1) structure.

  10. 21 CFR 172.250 - Petroleum naphtha.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Petroleum naphtha. 172.250 Section 172.250 Food and..., Films and Related Substances § 172.250 Petroleum naphtha. Petroleum naphtha may be safely used in food..., essentially paraffinic and naphthenic in nature obtained from petroleum, (b) The additive is refined to...

  11. 30 CFR 250.604 - Hydrogen sulfide.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Hydrogen sulfide. 250.604 Section 250.604... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Workover Operations § 250.604 Hydrogen sulfide. When a well-workover operation is conducted in zones known to contain hydrogen sulfide (H2S) or...

  12. 30 CFR 250.808 - Hydrogen sulfide.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Hydrogen sulfide. 250.808 Section 250.808... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Production Safety Systems § 250.808 Hydrogen sulfide. Production operations in zones known to contain hydrogen sulfide (H2S) or in zones where the presence of...

  13. 30 CFR 250.490 - Hydrogen sulfide.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Hydrogen sulfide. 250.490 Section 250.490... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Hydrogen Sulfide § 250.490 Hydrogen... black lettering as follows: Letter height Wording 12 inches Danger. Poisonous Gas. Hydrogen Sulfide....

  14. 30 CFR 250.504 - Hydrogen sulfide.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Hydrogen sulfide. 250.504 Section 250.504... OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Well-Completion Operations § 250.504 Hydrogen sulfide. When a well-completion operation is conducted in zones known to contain hydrogen sulfide (H2S) or...

  15. 32 CFR 250.6 - Responsibilities.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 250.6 Section 250.6 National... WITHHOLDING OF UNCLASSIFIED TECHNICAL DATA FROM PUBLIC DISCLOSURE § 250.6 Responsibilities. (a) The Under Secretary of Defense for Research and Engineering (USDR&E) shall have overall responsibility for...

  16. 49 CFR 250.3 - Fees.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Fees. 250.3 Section 250.3 Transportation Other... TRANSPORTATION GUARANTEE OF CERTIFICATES OF TRUSTEES OF RAILROADS IN REORGANIZATION § 250.3 Fees. On date of... Administrator as a guarantee fee such amount as the Administrator hereafter may determine and prescribe...

  17. 45 CFR 2541.250 - Program income.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Program income. 2541.250 Section 2541.250 Public... Post-Award Requirements § 2541.250 Program income. (a) General. Grantees are encouraged to earn income to defray program costs. Program income includes income from fees for services performed, from...

  18. 21 CFR 73.250 - Fruit juice.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Fruit juice. 73.250 Section 73.250 Food and Drugs... ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.250 Fruit juice. (a) Identity. (1) The color additive fruit juice is prepared either by expressing the juice from mature varieties of fresh, edible fruits, or...

  19. 8 CFR 250.1 - Application.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Application. 250.1 Section 250.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS REMOVAL OF ALIENS WHO HAVE FALLEN INTO DISTRESS § 250.1 Application. Application for removal shall be made on Form I-243. No appeal shall lie...

  20. 7 CFR 65.250 - Slaughter.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Slaughter. 65.250 Section 65.250 Agriculture..., PEANUTS, AND GINSENG General Provisions Definitions § 65.250 Slaughter. Slaughter means the point in which a livestock animal (including chicken) is prepared into meat products (covered commodities)...

  1. 30 CFR 250.300 - Pollution prevention.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Pollution prevention. 250.300 Section 250.300... OPERATIONS IN THE OUTER CONTINENTAL SHELF Pollution Prevention and Control § 250.300 Pollution prevention. (a... components which could cause unreasonable degradation to the marine environment. No...

  2. 7 CFR 250.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Administration. 250.2 Section 250.2 Agriculture... TERRITORIES AND POSSESSIONS AND AREAS UNDER ITS JURISDICTION General § 250.2 Administration. (a) Delegation to FNS. Within the Department, FNS shall act on behalf of the Department in the administration of...

  3. 30 CFR 250.1632 - Production rates.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Production rates. 250.1632 Section 250.1632 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1632 Production rates. Each...

  4. 30 CFR 250.1633 - Production measurement.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Production measurement. 250.1633 Section 250... SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Sulphur Operations § 250.1633 Production measurement. (a) General. Measurement equipment and security procedures shall be designed, installed, used, maintained,...

  5. 48 CFR 1846.672 - Preparing DD Forms 250 and 250c.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Preparing DD Forms 250 and 250c. 1846.672 Section 1846.672 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... DD Forms 250 and 250c....

  6. Anatomy of a controversy: Application of the Langevin technique to the analysis of the Californium-252 Source-Driven Noise Analysis method for subcriticality determination

    International Nuclear Information System (INIS)

    The expressions for the power spectral density of the noise equivalent sources have been calculated explicitly for the (a) stochastic transport equation, (b) the one-speed transport equaton, (c) the one-speed P1 equations, (d) the one-speed diffusion equation and (e) the point kinetic equation. The stochastic nature of Fick's law in (d) has been emphasized. The Langevin technique has been applied at various levels of approximation to the interpretation of the Californium-252 Source-Driven Noise Analysis (CSDNA) experiment for determining the reactivity in subcritical media. The origin of the controversy surrounding this method has been explained. The foundations of the CSDNA method as a viable experimental technique to infer subcriticality from a measured ratio of power spectral densities of the outputs of two neutron detectors and a third external source detector has been examined by solving the one-speed stochastic diffusion equation for a point external Californium-252 source and two detectors in an infinite medium. The expression relating reactivity to the measured ratio of PSDs was found to depend implicitly on k itself. Through a numerical analysis fo this expression, the authors have demonstrated that for a colinear detector-source-detector configuration for neutron detectors far from the source, the expression for the subcritical multiplication factor becomes essentially insensitive to k, hence, demonstrating some possibility for the viability of this technique. However, under more realistic experimental conditions, i.e., for finite systems in which diffusion theroy is not applicable, the measurement of the subcritical multiplication factor from a single measured ratio of PSDs, without extensive transport calculations, remains doubtful

  7. 21 CFR 74.250 - Orange B.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Orange B. 74.250 Section 74.250 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES SUBJECT TO CERTIFICATION Foods § 74.250 Orange B. (a) Identity. (1) The color additive Orange B is principally the disodium salt of...

  8. 40 CFR 35.250 - Purpose.

    Science.gov (United States)

    2010-07-01

    ... ASSISTANCE Environmental Program Grants Pesticide Program Implementation (section 23(a)(1)) § 35.250 Purpose. (a) Purpose of section. Sections 35.250 through 35.259 govern Pesticide Program Implementation Cooperative Agreements to States (as defined in section 2 of Federal Insecticide, Fungicide, and...

  9. 5 CFR 250.203 - Agency responsibilities.

    Science.gov (United States)

    2010-01-01

    ... 250.203 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT IN AGENCIES Strategic Human Capital Management § 250.203 Agency responsibilities. (a) To assist in the assessment of the management of human capital in the Federal Government, and to help meet...

  10. 30 CFR 250.1203 - Gas measurement.

    Science.gov (United States)

    2010-07-01

    ... CFR 250.198. (3) Ensure that the measurement components demonstrate consistent levels of accuracy... recorder is used, you must follow the recommendations in API MPMS as referenced in 30 CFR 250.198. (5) Take.... 1713 and 30 CFR part 212. (5) Upon the request of the Regional Supervisor, you must provide copies...

  11. English 304 & Communications 250: Professional Rhetorics

    Science.gov (United States)

    Hodgson, Justin

    2009-01-01

    This article provides a course overview of English 304 & Communications 250: Professional Rhetorics. This course was a pilot project instituted at Clemson University in spring of 2008. The project integrally linked English 304 (Business Writing) and Communications 250 (Public Speaking), requiring the same students to be enrolled in both 3…

  12. 36 CFR 2.50 - Special events.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Special events. 2.50 Section... PROTECTION, PUBLIC USE AND RECREATION § 2.50 Special events. (a) Sports events, pageants, regattas, public spectator attractions, entertainments, ceremonies, and similar events are allowed: Provided, however,...

  13. 7 CFR 250.21 - Civil rights.

    Science.gov (United States)

    2010-01-01

    ... rights. Distributing agencies, subdistributing agencies and recipient agencies shall comply with the Department's nondiscrimination regulations (7 CFR parts 15, 15a, and 15b) and the FNS civil rights... 7 Agriculture 4 2010-01-01 2010-01-01 false Civil rights. 250.21 Section 250.21...

  14. Californium-252 neutron sources

    International Nuclear Information System (INIS)

    Major production programs for the Savannah River reactors and the High Flux Isotopes Reactor at Oak Ridge have made 252Cf one of the most available and, at the USAEC's sales price of $10/μg, one of the least-expensive isotopic neutron sources. Reactor production has totaled approximately 2 g, and, based on expected demand, an additional 10 g will be produced in the next decade. The approximately 800 mg chemically separated to date has been used to prepare over 600 neutron sources. Most, about 500, have been medical sources containing 1 to 5 μg of 252Cf plated in needles for experimental cancer therapy studies. The remainder have generally been point sources containing 10 μg to 12 mg of oxide for activation, well logging, or radiography uses. Bulk sources have also been supplied to the commercial encapsulators. The latest development has been the production of 252Cf cermet wire which can be cut into almost contamination-free lengths of the desired 252Cf content. Casks are available for transport of sources up to 50 mg. Subcritical assemblies have been developed to multiply the source neutrons by a factor of 10 to 40, and collimators and thermalizers have also been extensively developed to shape the neutron flux and energy distributions for special applications. (U.S.)

  15. HTT 250 uop course tutorial/uop helP

    OpenAIRE

    baily

    2015-01-01

    HTT 250 Week 1 Assignment: Organization Chart Hotel Front Office HTT 250 Week 1 CheckPoint: Total Quality Management HTT 250 Week 1 CheckPoint: Lodging Properties HTT 250 Week 2 CheckPoint: Hotel Price Comparison HTT 250 Week 2 DQs HTT 250 Week 3 CheckPoint: Average Daily Rate HTT 250 Week 4 CheckPoint: Front Office FAQs HTT 250 Week 4 DQs HTT 250 Week 5 Assignment: Night Audit Application HTT 250 Week 5 CheckPoint: Night Audit HTT 250 Week 6 CheckPoint...

  16. 30 CFR 250.1201 - Definitions.

    Science.gov (United States)

    2010-07-01

    ...) from gas, including absorption, adsorption, or refrigeration. Processing does not include treatment... applicable chapter of the API MPMS, which is incorporated by reference in 30 CFR 250.198. Terms used...

  17. Californium interrogation prompt neutron (CIPN) instrument for non-destructive assay of spent nuclear fuel-Design concept and experimental demonstration

    Science.gov (United States)

    Henzlova, D.; Menlove, H. O.; Rael, C. D.; Trellue, H. R.; Tobin, S. J.; Park, Se-Hwan; Oh, Jong-Myeong; Lee, Seung-Kyu; Ahn, Seong-Kyu; Kwon, In-Chan; Kim, Ho-Dong

    2016-01-01

    This paper presents results of the first experimental demonstration of the Californium Interrogation Prompt Neutron (CIPN) instrument developed within a multi-year effort launched by the Next Generation Safeguards Initiative Spent Fuel Project of the United States Department of Energy. The goals of this project focused on developing viable non-destructive assay techniques with capabilities to improve an independent verification of spent fuel assembly characteristics. For this purpose, the CIPN instrument combines active and passive neutron interrogation, along with passive gamma-ray measurements, to provide three independent observables. This paper describes the initial feasibility demonstration of the CIPN instrument, which involved measurements of four pressurized-water-reactor spent fuel assemblies with different levels of burnup and two initial enrichments. The measurements were performed at the Post-Irradiation Examination Facility at the Korea Atomic Energy Institute in the Republic of Korea. The key aim of the demonstration was to evaluate CIPN instrument performance under realistic deployment conditions, with the focus on a detailed assessment of systematic uncertainties that are best evaluated experimentally. The measurements revealed good positioning reproducibility, as well as a high degree of insensitivity of the CIPN instrument's response to irregularities in a radial burnup profile. Systematic uncertainty of individual CIPN instrument signals due to assembly rotation was found to be orientation in the instrument.

  18. HIVAP calculations for the synthesis of new isotopes of Z=116 and Z=118 through 250Cm(48Ca, xn) and 250-252Cf(48Ca, xn) reactions

    International Nuclear Information System (INIS)

    The production and study of superheavy elements is an important area of research in contemporary experimental nuclear physics. The heaviest element produced so far is Z=118 (one isotope with A=294) in the 48Ca + 249Cf reaction with a production cross-section of 0.5 pico barns. Here we propose 250Cm(48Ca, xn) and 250-252Cf(48Ca, xn) reactions for the synthesis of heavier isotopes of Z=116 and 118 with comparable theoretical production cross-sections. 250Cm, 250Cf, 251Cf and 252Cf are feasible targets with half lives of 8300, 13.1, 898 and 2.6 years respectively

  19. 7 CFR 1726.250 - General.

    Science.gov (United States)

    2010-01-01

    ... ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Modifications to RUS Standard Contract Forms § 1726.250 General. RUS provides standard forms of contract for the procurement of materials, equipment, and construction and for contract amendments and various related forms for use by RUS borrowers. See § 1726.304...

  20. 40 CFR 264.250 - Applicability.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Waste Piles § 264.250... treat hazardous waste in piles, except as § 264.1 provides otherwise. (b) The regulations in...

  1. 7 CFR 250.15 - Financial management.

    Science.gov (United States)

    2010-01-01

    ... Uniform Federal Assistance Regulations, 7 CFR part 3015, subpart T. In no case may distribution charges be... under the cost Principles in the Department's Uniform Federal Assistance Regulations, 7 CFR part 3015... 7 Agriculture 4 2010-01-01 2010-01-01 false Financial management. 250.15 Section...

  2. Johann Wilhelm Krause 250 / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    2007-01-01

    Eesti klassitsistliku arhitektuuri suurkuju ning Tartu Ülikooli arhitekti Johann Wilhelm Krause 250. sünniaastapäeva tähistati näitustega Tallinnas ja Tartus. Tartu Ülikooli raamatukogu kunstikogusse kuulub ligi 700 J. W. Krause loodud joonistust

  3. 40 CFR 265.250 - Applicability.

    Science.gov (United States)

    2010-07-01

    ... Piles § 265.250 Applicability. The regulations in this subpart apply to owners and operators of facilities that treat or store hazardous waste in piles, except as § 265.1 provides otherwise. Alternatively, a pile of hazardous waste may be managed as a landfill under subpart N....

  4. Dicty_cDB: CFD250 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CF (Link to library) CFD250 (Link to dictyBase) - - - Contig-U16455-1 CFD250P (Link to Original site) CFD...250F 566 CFD250Z 716 CFD250P 1282 - - Show CFD250 Library CF (Link to library) Clone ID CFD...e URL http://dictycdb.biol.tsukuba.ac.jp/CSM/CF/CFD2-C/CFD250Q.Seq.d/ Representative seq. ID CFD...250P (Link to Original site) Representative DNA sequence >CFD250 (CFD250Q) /CSM/CF/CFD2-C/CFD...hqinrqespr*sr**ercccxskxeinx*k k Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value CFD250 (CFD

  5. Biological Efficiency of Californium-252 Source Evaluated by Comet Assay, Classical Cytogenetics and FISH in Human Lymphocytes Irradiated without and with BSH Pretreatment

    International Nuclear Information System (INIS)

    Biological effectiveness of californium-252 source was evaluated after irradiations in vitro of normal or pre-treated with compound enriched in B-10 ion cells. Peripheral blood lymphocytes were used as a model for human cells. DNA and chromosomal damage were studied to compare biological effectiveness of irradiation. Human blood samples or isolated lymphocytes were irradiated with the isotopic source of 252Cf, at the Faculty of Physics and Nuclear Techniques at the University of Mining and Metallurgy (both neutron source and samples were placed in ''infinite'' polyethylene block). Chemical pretreatment with Na210B12H11SH (BSH) was performed to introduce boron-10 ion into cells in order to check any enhancement effect due to the process of boron neutron capture. Single cell gel electrophoresis also known as the Comet assay was done to investigate the DNA damage. Classical cytogenetic analysis was applied to assess the frequencies of unstable aberrations (dicentrics, rings and a centric fragments). To evaluate the frequencies of stable aberrations the fluorescence in situ hybridisation (FISH) with probes for chromosomes 1, 4 (14.3% of the whole genome) was performed. Linear (or close to linear) increase with radiation dose were observed for the DNA damage and aberration frequencies in lymphocytes both untreated or pre-treated with BSH. Levels of translocations evaluated for the whole genome were comparable with the frequencies of dicentrics and rings. No significant differences were detected due to radiation dose in the frequencies of sister chromatid exchanges (SCE) detected in the second mitosis. No statistically significant differences were observed in various biological end-points between normal or boron pre-treated cells. (author)

  6. Hydrolysis and formation constants at 250C

    International Nuclear Information System (INIS)

    A database consisting of hydrolysis and formation constants for about 20 metals associated with the disposal of nuclear waste is given. Complexing ligands for the various ionic species of these metals include OH, F, Cl, SO4, PO4 and CO3. Table 1 consists of tabulated calculated and experimental values of log K/sub xy/, mainly at 250C and various ionic strengths together with references to the origin of the data. Table 2 consists of a column of recommended stability constants at 250C and zero ionic strength tabulated in the column headed log K/sub xy/(0); other columns contain coefficients for an extended Debye-Huckel equation to permit calculations of stability constants up to 3 ionic strength, and up to 0.7 ionic strength using the Davies equation. Selected stability constants calculated with these coefficients for various ionic strengths agree to an average of +- 2% when compared with published experimental and calculated values

  7. ACCELERATING POLARIZED PROTONS TO 250 GEV

    Energy Technology Data Exchange (ETDEWEB)

    BAI,M.; AHRENS, L.; ALEKSEEV, I.G.; ALESSI, J.; BEEBE-WANG, J.; ET AL.

    2007-06-25

    The Relativistic Heavy Ion Collider (RHIC) as the first high energy polarized proton collider was designed t o provide polarized proton collisions a t a maximum beam energy of 250 GeV. I t has been providing collisions a t a beam energy of 100 Gel' since 2001. Equipped with two full Siberian snakes in each ring, polarization is preserved during the acceleration from injection to 100 GeV with careful control of the betatron tunes and the vertical orbit distortions. However, the intrinsic spin resonances beyond 100 GeV are about a factor of two stronger than those below 100 GeV? making it important t o examine the impact of these strong intrinsic spin resonances on polarization survival and the tolerance for vertical orbit distortions. Polarized protons were accelerated t o the record energy of 250 GeV in RHIC with a polarization of 46% measured a t top energy in 2006. The polarization measurement as a function of beam energy also shows some polarization loss around 136 GeV, the first strong intrinsic resonance above 100 GeV. This paper presents the results and discusses the sensitivity of the polarization survival t o orbit distortions.

  8. Dicty_cDB: SSI250 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 250Z (Link to Original site) - - SSI250Z 697 - - - - Show SSI250 Library SS (Link to library) Clone ID SSI...Representative seq. ID SSI250Z (Link to Original site) Representative DNA sequence >SSI250 (SSI250Q) /CSM/SS/SSI2-C/SSI...I*inpyqnfytgnq Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SSI...SS (Link to library) SSI250 (Link to dictyBase) - G00812 DDB0231535 Contig-U05055-1 SSI...250 (Link to dictyBase) Atlas ID - NBRP ID G00812 dictyBase ID DDB0231535 Link to Contig Contig-U05055-1 Original si

  9. 41 CFR 60-250.68 - Reinstatement of ineligible contractors.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Reinstatement of ineligible contractors. 60-250.68 Section 60-250.68 Public Contracts and Property Management Other Provisions... OTHER PROTECTED VETERANS General Enforcement and Complaint Procedures § 60-250.68 Reinstatement...

  10. 41 CFR 60-250.65 - Enforcement proceedings.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Enforcement proceedings. 60-250.65 Section 60-250.65 Public Contracts and Property Management Other Provisions Relating to... PROTECTED VETERANS General Enforcement and Complaint Procedures § 60-250.65 Enforcement proceedings....

  11. 41 CFR 60-250.63 - Violation of conciliation agreements.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Violation of conciliation agreements. 60-250.63 Section 60-250.63 Public Contracts and Property Management Other Provisions Relating to... PROTECTED VETERANS General Enforcement and Complaint Procedures § 60-250.63 Violation of...

  12. 41 CFR 60-250.62 - Conciliation agreements.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Conciliation agreements. 60-250.62 Section 60-250.62 Public Contracts and Property Management Other Provisions Relating to... PROTECTED VETERANS General Enforcement and Complaint Procedures § 60-250.62 Conciliation agreements. If...

  13. 41 CFR 60-250.61 - Complaint procedures.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Complaint procedures. 60-250.61 Section 60-250.61 Public Contracts and Property Management Other Provisions Relating to Public... VETERANS General Enforcement and Complaint Procedures § 60-250.61 Complaint procedures. (a) Place and...

  14. 41 CFR 60-250.60 - Compliance evaluations.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Compliance evaluations. 60-250.60 Section 60-250.60 Public Contracts and Property Management Other Provisions Relating to... PROTECTED VETERANS General Enforcement and Complaint Procedures § 60-250.60 Compliance evaluations....

  15. 41 CFR 60-250.67 - Notification of agencies.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Notification of agencies. 60-250.67 Section 60-250.67 Public Contracts and Property Management Other Provisions Relating to... PROTECTED VETERANS General Enforcement and Complaint Procedures § 60-250.67 Notification of agencies....

  16. 41 CFR 60-250.66 - Sanctions and penalties.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Sanctions and penalties. 60-250.66 Section 60-250.66 Public Contracts and Property Management Other Provisions Relating to... PROTECTED VETERANS General Enforcement and Complaint Procedures § 60-250.66 Sanctions and penalties....

  17. 41 CFR 60-250.69 - Intimidation and interference.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Intimidation and interference. 60-250.69 Section 60-250.69 Public Contracts and Property Management Other Provisions Relating to... PROTECTED VETERANS General Enforcement and Complaint Procedures § 60-250.69 Intimidation and...

  18. 7 CFR 250.68 - Nutrition Services Incentive Program (NSIP).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Nutrition Services Incentive Program (NSIP). 250.68 Section 250.68 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION... Donated Food Outlets § 250.68 Nutrition Services Incentive Program (NSIP). (a) Distribution of...

  19. 6 CFR 27.250 - Inspections and audits.

    Science.gov (United States)

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Inspections and audits. 27.250 Section 27.250 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Chemical Facility Security Program § 27.250 Inspections and audits. (a) Authority. In order...

  20. 30 CFR 250.1002 - Design requirements for DOI pipelines.

    Science.gov (United States)

    2010-07-01

    ... 30 CFR 250.198) where— P=Internal design pressure in pounds per square inch (psi). S=Specified..., API Spec 6A, or the equivalent (incorporated by reference as specified in 30 CFR 250.198). Each flange... Spec 17J, incorporated by reference as specified in 30 CFR 250.198. (5) You must design pipeline...

  1. 7 CFR 58.250 - Dry whole milk.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Dry whole milk. 58.250 Section 58.250 Agriculture... Products Bearing Usda Official Identification § 58.250 Dry whole milk. Dry whole milk in commercial bulk... Grades of Dry Whole Milk. Quality requirements for dry whole milk in consumer packages shall be for...

  2. 7 CFR 250.30 - State processing of donated foods.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false State processing of donated foods. 250.30 Section 250... of Donated Foods § 250.30 State processing of donated foods. (a) General. This section sets forth the... may enter into contracts for the processing of donated foods and prescribes the minimum...

  3. 31 CFR 250.6 - Powers of attorney.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Powers of attorney. 250.6 Section 250... SETTLEMENT COMMISSION OF THE UNITED STATES § 250.6 Powers of attorney. No power of attorney to sign a voucher application will be recognized but a power of attorney executed subsequent to the certification of an award...

  4. 30 CFR 250.302 - Definitions concerning air quality.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Definitions concerning air quality. 250.302... Definitions concerning air quality. For purposes of §§ 250.303 and 250.304 of this part: Air pollutant means..., pursuant to section 109 of the Clean Air Act, national primary or secondary ambient air quality...

  5. 7 CFR 958.250 - Assessment Credit Report.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Assessment Credit Report. 958.250 Section 958.250... DESIGNATED COUNTIES IN IDAHO, AND MALHEUR COUNTY, OREGON Rules and Regulations § 958.250 Assessment Credit Report. Each handler may receive a credit for assessments on onions that have been levied in...

  6. 41 CFR 60-250.22 - Direct threat defense.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Direct threat defense. 60-250.22 Section 60-250.22 Public Contracts and Property Management Other Provisions Relating to Public... VETERANS Discrimination Prohibited § 60-250.22 Direct threat defense. The contractor may use as...

  7. 21 CFR 173.250 - Methyl alcohol residues.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Methyl alcohol residues. 173.250 Section 173.250... CONSUMPTION Solvents, Lubricants, Release Agents and Related Substances § 173.250 Methyl alcohol residues... oleoresins as a residue from the extraction of spice, at a level not to exceed 50 parts per million. (b)...

  8. 250 Years of the State Survey

    Directory of Open Access Journals (Sweden)

    Ivana Wechselberger

    2014-06-01

    Full Text Available The first topographic survey of the Habsburg Monarchy was decreed by Maria Theresa 250 years ago, on May 13, 1764. A conference was held on the occasion of the anniversary by the Austrian State Geodetic Administration (BEV – Bundesamt für Eich- und Vermessungswesen and the Institute for Military Geosciences (IMG – Institut für Militärisches Geowesen in Vienna on May 13 and 14, 2014. The conference was sort of a time travel through Austrian state surveys. Historical development and methods of the first three state surveys (18th and 19th century were presented on the first conference day. Lectures were held by representatives of Austrian scientific institutions and new countries of the Monarchy. The second conference day was dedicated to the 4th state survey (20th century and its impact on civilian and military application and economy.

  9. 21 CFR 137.250 - White corn meal.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false White corn meal. 137.250 Section 137.250 Food and... Related Products § 137.250 White corn meal. (a) White corn meal is the food prepared by so grinding... fiber content of the finished corn meal is not less than 1.2 percent and not more than that of...

  10. Californium Recovery from Palladium Wire

    Energy Technology Data Exchange (ETDEWEB)

    Burns, Jon D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2014-08-01

    The recovery of 252Cf from palladium-252Cf cermet wires was investigated to determine the feasibility of implementing it into the cermet wire production operation at Oak Ridge National Laboratory’s Radiochemical Engineering Development Center. The dissolution of Pd wire in 8 M HNO3 and trace amounts of HCl was studied at both ambient and elevated temperatures. These studies showed that it took days to dissolve the wire at ambient temperature and only 2 hours at 60°C. Adjusting the ratio of the volume of solvent to the mass of the wire segment showed little change in the kinetics of dissolution, which ranged from 0.176 mL/mg down to 0.019 mL/mg. A successful chromatographic separation of 153Gd, a surrogate for 252Cf, from Pd was demonstrated using AG 50x8 cation exchange resin with a bed volume of 0.5 mL and an internal diameter of 0.8 cm.

  11. Increased N250 amplitudes for other-race faces reflect more effortful processing at the individual level.

    Science.gov (United States)

    Herzmann, Grit

    2016-07-01

    The N250 and N250r (r for repetition, signaling a difference measure of priming) has been proposed to reflect the activation of perceptual memory representations for individual faces. Increased N250r and N250 amplitudes have been associated with higher levels of familiarity and expertise, respectively. In contrast to these observations, the N250 amplitude has been found to be larger for other-race than own-race faces in recognition memory tasks. This study investigated if these findings were due to increased identity-specific processing demands for other-race relative to own-race faces and whether or not similar results would be obtained for the N250 in a repetition priming paradigm. Only Caucasian participants were available for testing and completed two tasks with Caucasian, African-American, and Chinese faces. In a repetition priming task, participants decided whether or not sequentially presented faces were of the same identity (individuation task) or same race (categorization task). Increased N250 amplitudes were found for African-American and Chinese faces relative to Caucasian faces, replicating previous results in recognition memory tasks. Contrary to the expectation that increased N250 amplitudes for other-race face would be confined to the individuation task, both tasks showed similar results. This could be due to the fact that face identity information needed to be maintained across the sequential presentation of prime and target in both tasks. Increased N250 amplitudes for other-race faces are taken to represent increased neural demands on the identity-specific processing of other-race faces, which are typically processed less holistically and less on the level of the individual. PMID:27184183

  12. 30 CFR 250.510 - Diesel engine air intakes.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Diesel engine air intakes. 250.510 Section 250... engine air intakes. Diesel engine air intakes must be equipped with a device to shut down the diesel engine in the event of runaway. Diesel engines that are continuously attended must be equipped...

  13. 30 CFR 250.610 - Diesel engine air intakes.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Diesel engine air intakes. 250.610 Section 250... engine air intakes. No later than May 31, 1989, diesel engine air intakes shall be equipped with a device to shut down the diesel engine in the event of runaway. Diesel engines which are...

  14. 41 CFR 60-250.24 - Drugs and alcohol.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Drugs and alcohol. 60-250... VETERANS Discrimination Prohibited § 60-250.24 Drugs and alcohol. (a) Specific activities permitted. The contractor: (1) May prohibit the illegal use of drugs and the use of alcohol at the workplace by...

  15. 30 CFR 250.1616 - Supervision, surveillance, and training.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Supervision, surveillance, and training. 250.1616 Section 250.1616 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... Supervision, surveillance, and training. (a) The lessee shall provide onsite supervision of...

  16. 33 CFR 105.250 - Security systems and equipment maintenance.

    Science.gov (United States)

    2010-07-01

    ... maintenance. 105.250 Section 105.250 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... systems and equipment maintenance. (a) Security systems and equipment must be in good working order and... include procedures for identifying and responding to security system and equipment failures...

  17. 30 CFR 250.1624 - Blowout prevention equipment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Blowout prevention equipment. 250.1624 Section 250.1624 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND... prevention equipment. (a) The BOP system and system components and related well-control equipment shall...

  18. 30 CFR 250.615 - Blowout prevention equipment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Blowout prevention equipment. 250.615 Section 250.615 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS... Blowout prevention equipment. (a) The BOP system, system components and related well-control...

  19. 30 CFR 250.515 - Blowout prevention equipment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Blowout prevention equipment. 250.515 Section 250.515 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS... Blowout prevention equipment. (a) The BOP system and system components and related well-control...

  20. 30 CFR 250.101 - Authority and applicability.

    Science.gov (United States)

    2010-07-01

    ... 250.101 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General Authority and Definition of Terms § 250... Management Service (MMS) to regulate oil, gas, and sulphur exploration, development, and...

  1. 21 CFR 333.250 - Labeling of antifungal drug products.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Labeling of antifungal drug products. 333.250... Antifungal Drug Products § 333.250 Labeling of antifungal drug products. (a) Statement of identity. The... “antifungal.” (b) Indications. The labeling of the product states, under the heading “Indications,” the...

  2. 42 CFR 447.250 - Basis and purpose.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Basis and purpose. 447.250 Section 447.250 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... requires that payments be consistent with efficiency, economy, and quality of care; (c) Sections 447.253...

  3. 7 CFR 765.208-765.250 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false 765.208-765.250 Section 765.208-765.250 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS DIRECT LOAN SERVICING-REGULAR Protecting the Agency's Security Interest §§...

  4. First demonstration of a vehicle mounted 250GHz real time passive imager

    Science.gov (United States)

    Mann, Chris

    2009-05-01

    This paper describes the design and performance of a ruggedized passive Terahertz imager, the frequency of operation is a 40GHz band centred around 250GHz. This system has been specifically targeted at vehicle mounted operation, outdoors in extreme environments. The unit incorporates temperature stabilization along with an anti-vibration chassis and is sealed to allow it to be used in a dusty environment. Within the system, a 250GHz heterodyne detector array is mated with optics and scanner to allow real time imaging out to 100 meters. First applications are envisaged to be stand-off, person borne IED detection to 30 meters but the unique properties in this frequency band present other potential uses such as seeing through smoke and fog. The possibility for use as a landing aid is discussed. A detailed description of the system design and video examples of typical imaging output will be presented.

  5. Superfund GIS - 1:250,000 Geology of Tennessee.

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set is a digital representation of the printed 1:250,000 geologic maps from the Tennessee Department of Environment and Conservation, Division of Geology....

  6. Alaska map quadrangles at 1:250,000 scale

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Outlines of 1:250,000 scale map quadrangles in Alaska for use as a geographic reference within Google Earth or other software capable of interpreting KML, with...

  7. Design of a homogeneous subcritical nuclear reactor based on thorium with a source of californium 252; Diseno de un reactor nuclear subcritico homogeneo a base de Torio con una fuente de Californio 252

    Energy Technology Data Exchange (ETDEWEB)

    Delgado H, C. E.; Vega C, H. R. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas, Zac. (Mexico); Sajo B, L., E-mail: ce_delgado89@hotmail.com [Universidad Simon Bolivar, Laboratorio de Fisica Nuclear, Apdo. 89000, 1080A Caracas (Venezuela, Bolivarian Republic of)

    2015-10-15

    Full text: One of the energy alternatives to fossil fuels which do not produce greenhouse gases is the nuclear energy. One of the drawbacks of this alternative is the generation of radioactive wastes of long half-life and its relation to the generation of nuclear materials to produce weapons of mass destruction. An option to these drawbacks of nuclear energy is to use Thorium as part of the nuclear fuel which it becomes in U{sup 233} when capturing neutrons, that is a fissile material. In this paper Monte Carlo methods were used to design a homogeneous subcritical reactor based on thorium. As neutron reflector graphite was used. The reactor core is homogeneous and is formed of 70% light water as moderator, 12% of enriched uranium UO{sub 2}(NO{sub 3}){sub 4} and 18% of thorium Th(NO{sub 3}){sub 4} as fuel. To start the nuclear fission chain reaction an isotopic source of californium 252 was used with an intensity of 4.6 x 10{sup 7} s{sup -1}. In the design the value of the effective multiplication factor, whose value turned out k{sub eff} <1 was calculated. Also, the neutron spectra at different distances from the source and the total fluence were calculated, as well as the values of the ambient dose equivalent in the periphery of the reactor. (Author)

  8. Hybrid Propulsion Demonstration Program 250K Hybrid Motor

    Science.gov (United States)

    Story, George; Zoladz, Tom; Arves, Joe; Kearney, Darren; Abel, Terry; Park, O.

    2003-01-01

    The Hybrid Propulsion Demonstration Program (HPDP) program was formed to mature hybrid propulsion technology to a readiness level sufficient to enable commercialization for various space launch applications. The goal of the HPDP was to develop and test a 250,000 pound vacuum thrust hybrid booster in order to demonstrate hybrid propulsion technology and enable manufacturing of large hybrid boosters for current and future space launch vehicles. The HPDP has successfully conducted four tests of the 250,000 pound thrust hybrid rocket motor at NASA's Stennis Space Center. This paper documents the test series.

  9. New model for the lunar interior to 250 km

    International Nuclear Information System (INIS)

    A new model for the structure of the lunar interior to about a 250-km depth is proposed. It is suggested that this region is composed of plagioclase-bearing rocks, and that the 65-km seismic discontinuity represents the appearance of garnet. A variety of rock types mainly composed of plagioclase, pyroxene, olivine and garnet is envisioned, with at least half of the outer 250 km of the moon made of plagioclase, which dominates the electrical conductivity. This model agrees with recent petrological and electrical conductivity results and does not violate velocity-depth profiles obtained from elastic-wave studies of lunar and terrestrial materials. (U.S.)

  10. 41 CFR 60-250.64 - Show cause notices.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Show cause notices. 60... VETERANS General Enforcement and Complaint Procedures § 60-250.64 Show cause notices. When the Deputy Assistant Secretary has reasonable cause to believe that the contractor has violated the Act or this...

  11. 30 CFR 250.1202 - Liquid hydrocarbon measurement.

    Science.gov (United States)

    2010-07-01

    ... applications Creation of new facility measurement points (FMPs); Association of leases or units with existing... the API MPMS as incorporated by reference in 30 CFR 250.198, when obtaining net standard volume and... displacement (pipe) prover, master meter, or tank prover; (iii) A proportional-to-flow sampling device...

  12. 5 CFR 250.202 - Office of Personnel Management responsibilities.

    Science.gov (United States)

    2010-01-01

    ... REGULATIONS PERSONNEL MANAGEMENT IN AGENCIES Strategic Human Capital Management § 250.202 Office of Personnel... Governmentwide leadership and direction in the strategic management of the Federal workforce. (b) To execute this... to which human capital management strategies are integrated into agency strategic plans...

  13. 5 CFR 250.201 - Coverage and purpose.

    Science.gov (United States)

    2010-01-01

    ....201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT IN AGENCIES Strategic Human Capital Management § 250.201 Coverage and purpose. The Chief Human... the strategic management of the Federal civil service, and pursuant to 5 U.S.C. 1103, OPM...

  14. The Varian MAT-250 mass spectrometer. Steady isotopes laboratory

    International Nuclear Information System (INIS)

    This work treats over the performance and applications of the Varian Mat-250 mass spectrometer which is in the environmental isotope laboratory. It can be applied over topics such as: ions formation, acceleration and collimation, ions separation, ions detection, data transformation, sampling, δ notation. (Author)

  15. 30 CFR 250.611 - Traveling-block safety device.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Traveling-block safety device. 250.611 Section... Traveling-block safety device. After May 31, 1989, all units being used for well-workover operations which have both a traveling block and a crown block shall be equipped with a safety device which is...

  16. 30 CFR 250.511 - Traveling-block safety device.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Traveling-block safety device. 250.511 Section... Traveling-block safety device. All units being used for well-completion operations that have both a traveling block and a crown block must be equipped with a safety device that is designed to prevent...

  17. 30 CFR 250.102 - What does this part do?

    Science.gov (United States)

    2010-07-01

    ... Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General Authority and Definition of Terms § 250.102 What does this... CFR 254. (11) Oil and gas well-completion operations E. (12) Oil and gas well-workover operations...

  18. 9 CFR 2.50 - Time and method of identification.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Time and method of identification. 2... AGRICULTURE ANIMAL WELFARE REGULATIONS Identification of Animals § 2.50 Time and method of identification. (a... by any dealer or exhibitor shall be identified by the dealer or exhibitor at the time of delivery...

  19. 41 CFR 60-250.23 - Medical examinations and inquiries.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Medical examinations and... PROTECTED VETERANS Discrimination Prohibited § 60-250.23 Medical examinations and inquiries. (a) Prohibited medical examinations or inquiries. Except as stated in paragraphs (b) and (c) of this section, it...

  20. 38 CFR 3.250 - Dependency of parents; compensation.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Dependency of parents....250 Dependency of parents; compensation. (a) Income—(1) Conclusive dependency. Dependency of a parent... not exceed: (i) $400 for a mother or father not living together; (ii) $660 for a mother and father,...

  1. The Varian MAT-250 mass spectrometer. Steady isotopes laboratory; Espectrometro de masas Varian MAT-250. Laboratorio de isotopos estables

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez M, V.; Tavera D, M.L. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1997-07-01

    This work treats over the performance and applications of the Varian Mat-250 mass spectrometer which is in the environmental isotope laboratory. It can be applied over topics such as: ions formation, acceleration and collimation, ions separation, ions detection, data transformation, sampling, {delta} notation. (Author)

  2. CERN: Fixed target targets

    International Nuclear Information System (INIS)

    Full text: While the immediate priority of CERN's research programme is to exploit to the full the world's largest accelerator, the LEP electron-positron collider and its concomitant LEP200 energy upgrade (January, page 1), CERN is also mindful of its long tradition of diversified research. Away from LEP and preparations for the LHC proton-proton collider to be built above LEP in the same 27-kilometre tunnel, CERN is also preparing for a new generation of heavy ion experiments using a new source, providing heavier ions (April 1992, page 8), with first physics expected next year. CERN's smallest accelerator, the LEAR Low Energy Antiproton Ring continues to cover a wide range of research topics, and saw a record number of hours of operation in 1992. The new ISOLDE on-line isotope separator was inaugurated last year (July, page 5) and physics is already underway. The remaining effort concentrates around fixed target experiments at the SPS synchrotron, which formed the main thrust of CERN's research during the late 1970s. With the SPS and LEAR now approaching middle age, their research future was extensively studied last year. Broadly, a vigorous SPS programme looks assured until at least the end of 1995. Decisions for the longer term future of the West Experimental Area of the SPS will have to take into account the heavy demand for test beams from work towards experiments at big colliders, both at CERN and elsewhere. The North Experimental Area is the scene of larger experiments with longer lead times. Several more years of LEAR exploitation are already in the pipeline, but for the longer term, the ambitious Superlear project for a superconducting ring (January 1992, page 7) did not catch on. Neutrino physics has a long tradition at CERN, and this continues with the preparations for two major projects, the Chorus and Nomad experiments (November 1991, page 7), to start next year in the West Area. Delicate neutrino oscillation effects could become

  3. Sputter target

    Science.gov (United States)

    Gates, Willard G.; Hale, Gerald J.

    1980-01-01

    The disclosure relates to an improved sputter target for use in the deposition of hard coatings. An exemplary target is given wherein titanium diboride is brazed to a tantalum backing plate using a gold-palladium-nickel braze alloy.

  4. Development Status of Power Processing Unit for 250mN-Class Hall Thruster

    Science.gov (United States)

    Osuga, H.; Suzuki, K.; Ozaki, T.; Nakagawa, T.; Suga, I.; Tamida, T.; Akuzawa, Y.; Suzuki, H.; Soga, Y.; Furuichi, T.; Maki, S.; Matui, K.

    2008-09-01

    Institute for Unmanned Space Experiment Free Flyer (USEF) and Mitsubishi Electric Corporation (MELCO) are developing the next generation ion engine system under the sponsorship of Ministry of Economy, Trade and Industry (METI) within six years. The system requirement specifications are a thrust level of over 250mN and specific impulse of over 1500 sec with a less than 5kW electric power supply, and a lifetime of over 3,000 hours. These target specifications required the development of both a Hall Thruster and a Power Processing Unit (PPU). In the 2007 fiscal year, the PPU called Second Engineering Model (EM2) consist of all power supplies was a model for the Hall Thruster system. The EM2 PPU showed the discharge efficiency was over 96.2% for 250V and 350V at output power between 1.8kW to 4.5kW. And also the Hall Thruster could start up quickly and smoothly to control the discharge voltage, the inner magnet current, the outer magnet current and the xenon flow rate. This paper reports on the design and test results of the EM2 PPU.

  5. Tourette syndrome: clinical and psychological aspects of 250 cases.

    OpenAIRE

    Comings, D E; Comings, B G

    1985-01-01

    Tourette syndrome is a common hereditary neuropsychiatric disorder consisting of multiple tics and vocal noises. We summarize here clinical aspects of 250 consecutive cases seen over a period of 3 years. The sex ratio was four males to one female, and the mean age of onset was 6.9 years. Only 10% were Jewish, indicating that it is not more prevalent in Ashkenazi Jews. Only 33% had compulsive swearing (coprolalia), indicating that this is not necessary for the diagnosis. The most frequent init...

  6. Superfund GIS - 1:250,000 Geology of Tennessee

    Science.gov (United States)

    Greene, D.C.; Wolfe, W.J.

    2000-01-01

    This data set is a digital representation of the printed 1:250,000 geologic maps from the Tennessee Department of Environment and Conservation, Division of Geology. The coverage was designed primarily to provide a more detailed geologic base than the 1:2,500,000 King and Beikman (1974). 1:24,000 scale coverage of the state is available for about 40 percent of the state. Formation names and geologic unit codes used in the coverage are from the Tennessee Division of Geology published maps and may not conform to USGS nomenclature. The Tennessee Division of Geology can be contacted at (615) 532-1500

  7. Antiproton Target

    CERN Multimedia

    1980-01-01

    Antiproton target used for the AA (antiproton accumulator). The first type of antiproton production target used from 1980 to 1982 comprised a rod of copper 3mm diameter and 120mm long embedded in a graphite cylinder that was itself pressed into a finned aluminium container. This assembly was air-cooled and it was used in conjunction with the Van der Meer magnetic horn. In 1983 Fermilab provided us with lithium lenses to replace the horn with a view to increasing the antiproton yield by about 30%. These lenses needed a much shorter target made of heavy metal - iridium was chosen for this purpose. The 50 mm iridium rod was housed in an extension to the original finned target container so that it could be brought very close to the entrance to the lithium lens. Picture 1 shows this target assembly and Picture 2 shows it mounted together with the lithium lens. These target containers had a short lifetime due to a combination of beam heating and radiation damage. This led to the design of the water-cooled target in...

  8. 20 CFR 1010.250 - Can priority of service be waived?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Can priority of service be waived? 1010.250 Section 1010.250 Employees' Benefits OFFICE OF THE ASSISTANT SECRETARY FOR VETERANS' EMPLOYMENT AND... Priority of Service § 1010.250 Can priority of service be waived? No, priority of service cannot be waived....

  9. 30 CFR 250.1010 - General requirements for pipeline right-of-way holders.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false General requirements for pipeline right-of-way holders. 250.1010 Section 250.1010 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Rights-of-Way § 250.1010 General requirements for pipeline right-of-way holders. An applicant,...

  10. 7 CFR 250.52 - Storage and inventory management of donated foods.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Storage and inventory management of donated foods. 250... Donated Foods in Contracts With Food Service Management Companies § 250.52 Storage and inventory... general requirements in § 250.14(b) for the storage and inventory management of donated foods. (b)...

  11. 21 CFR 250.101 - Amphetamine and methamphetamine inhalers regarded as prescription drugs.

    Science.gov (United States)

    2010-04-01

    ... as prescription drugs. 250.101 Section 250.101 Food and Drugs FOOD AND DRUG ADMINISTRATION... DRUGS New Drug or Prescription Status of Specific Drugs § 250.101 Amphetamine and methamphetamine... should not be freely available to the public through over-the-counter sale. From complaints by...

  12. 17 CFR 250.7 - Companies deemed not to be electric or gas utility companies.

    Science.gov (United States)

    2010-04-01

    ... electric or gas utility companies. 250.7 Section 250.7 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 Registration and General Exemptions § 250.7 Companies deemed not to be electric or gas utility companies....

  13. 40 CFR 421.250 - Applicability: Description of the primary precious metals and mercury subcategory.

    Science.gov (United States)

    2010-07-01

    ... primary precious metals and mercury subcategory. 421.250 Section 421.250 Protection of Environment... POINT SOURCE CATEGORY Primary Precious Metals and Mercury Subcategory § 421.250 Applicability: Description of the primary precious metals and mercury subcategory. The provisions of this subpart...

  14. 30 CFR 250.1012 - Required payments for pipeline right-of-way holders.

    Science.gov (United States)

    2010-07-01

    ... in 30 CFR 218.54. If you fail to make a payment that is late after written notice from MMS, MMS may initiate cancellation of the right-of-use grant and easement under 30 CFR 250.1013. ... holders. 250.1012 Section 250.1012 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF...

  15. 30 CFR 250.1011 - Bond requirements for pipeline right-of-way holders.

    Science.gov (United States)

    2010-07-01

    ... holders. 250.1011 Section 250.1011 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Rights-of-Way § 250.1011 Bond requirements for pipeline right-of-way holders. (a) When you apply for, or are the holder of, a right-of-way, you must: (1) Provide and maintain a $300,000 bond (in addition...

  16. 30 CFR 250.411 - What information must I submit with my application?

    Science.gov (United States)

    2010-07-01

    ... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.411 What information must I submit with my application? In addition to... proposed well § 250.412 (b) Design criteria used for the proposed well § 250.413 (c) Drilling...

  17. 17 CFR 250.60 - Meaning of word “authorization”.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Meaning of word... Reorganizations § 250.60 Meaning of word “authorization”. The word “authorization”, as used in §§ 250.60 to 250.64, includes “any proxy, consent, authorization, power of attorney, deposit, or dissent”, as those words...

  18. 20 CFR 416.250 - Experimental, pilot, and demonstration projects in the SSI program.

    Science.gov (United States)

    2010-04-01

    ... projects in the SSI program. 416.250 Section 416.250 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... Because of Essential Persons § 416.250 Experimental, pilot, and demonstration projects in the SSI program... administration of the SSI program. These projects will test the advantages of altering certain...

  19. 30 CFR 250.1004 - Safety equipment requirements for DOI pipelines.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Safety equipment requirements for DOI pipelines. 250.1004 Section 250.1004 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR...-Way § 250.1004 Safety equipment requirements for DOI pipelines. (a) The lessee shall ensure the...

  20. 30 CFR 250.1003 - Installation, testing, and repair requirements for DOI pipelines.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Installation, testing, and repair requirements for DOI pipelines. 250.1003 Section 250.1003 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT... and Pipeline Rights-of-Way § 250.1003 Installation, testing, and repair requirements for DOI...

  1. 30 CFR 250.516 - Blowout preventer system tests, inspections, and maintenance.

    Science.gov (United States)

    2010-07-01

    ... Well-Completion Operations § 250.516 Blowout preventer system tests, inspections, and maintenance. (a... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Blowout preventer system tests, inspections, and maintenance. 250.516 Section 250.516 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT...

  2. 30 CFR 250.109 - What documents must I prepare and maintain related to welding?

    Science.gov (United States)

    2010-07-01

    ... related to welding? 250.109 Section 250.109 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF... Performance Standards § 250.109 What documents must I prepare and maintain related to welding? (a) You must submit a Welding Plan to the District Manager before you begin drilling or production activities on...

  3. 30 CFR 250.104 - How may I appeal a decision made under MMS regulations?

    Science.gov (United States)

    2010-07-01

    ... regulations? 250.104 Section 250.104 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General Authority and Definition... decisions issued under MMS regulations in 30 CFR parts 250 to 282, follow the procedures in 30 CFR part 290....

  4. 30 CFR 250.226 - What Coastal Zone Management Act (CZMA) information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What Coastal Zone Management Act (CZMA) information must accompany the EP? 250.226 Section 250.226 Mineral Resources MINERALS MANAGEMENT SERVICE... and Information Contents of Exploration Plans (ep) § 250.226 What Coastal Zone Management Act...

  5. Bayesian demography 250 years after Bayes.

    Science.gov (United States)

    Bijak, Jakub; Bryant, John

    2016-01-01

    Bayesian statistics offers an alternative to classical (frequentist) statistics. It is distinguished by its use of probability distributions to describe uncertain quantities, which leads to elegant solutions to many difficult statistical problems. Although Bayesian demography, like Bayesian statistics more generally, is around 250 years old, only recently has it begun to flourish. The aim of this paper is to review the achievements of Bayesian demography, address some misconceptions, and make the case for wider use of Bayesian methods in population studies. We focus on three applications: demographic forecasts, limited data, and highly structured or complex models. The key advantages of Bayesian methods are the ability to integrate information from multiple sources and to describe uncertainty coherently. Bayesian methods also allow for including additional (prior) information next to the data sample. As such, Bayesian approaches are complementary to many traditional methods, which can be productively re-expressed in Bayesian terms. PMID:26902889

  6. Corrosion of titanium in phosphoric acid at 250

    Institute of Scientific and Technical Information of China (English)

    LU Jian-shu

    2009-01-01

    Corrosion studies of a commercially pure titanium in phosphoric acid solutions at 250 ℃ were carried out by immersion test in an autoclave. At lower phosphoric acid concentration (0.1 mol/L), the corrosion was mild. At higher phosphoric concentration (1.0 mol/L) corrosion, a 25 μm-thick white corrosion products layer was formed on the samples after 24 h immersion. XRD analysis shows that the white layer consists mainly of titanium oxide phosphate hydrate (π-Ti2O(PO4)2·2H2O). The corrosion product shows the morphology of fiber bundles. A thermodynamic analysis of the formation of the corrosion product is presented.

  7. Standard potential of sodium amalgam at 250C

    International Nuclear Information System (INIS)

    From a set of critically selected literary data on the emf's of concentration cells consisting of sodium metal and sodium amalgam in a sodium salt non-aqueous electrolyte a value of E0sub(Na(Hg)/Na+) = -1.95584 V was calculated for the standard equilibrium potential of diluted liquid sodium amalgam at 250C. The standard state of the amalgam was derived from an amalgam at infinite dilution where fsub(Na)→ 1.0 for xsub(Na)→ 0. The activity coefficient of sodium in the amalgam at an arbitrary composition, corresponding to this standard state, is obtained from the expression 1g fsub(Na(Hg)) = 16.393 xsub(Na). (author)

  8. Flood basalt volcanism during the past 250 million years

    Science.gov (United States)

    Rampino, Michael R.; Stothers, Richard B.

    1988-01-01

    A chronology of the initiation dates of major continental flood basalt volcanism is established from published potassium-argon (K-Ar) and argon-argon (Ar-Ar) ages of basaltic rocks and related basic intrusions. The dating is therefore independent of the biostratigraphic and paleomagnetic time scales. Estimated errors of the initiation dates of the volcanic episodes determined from the distributions of the radiometric ages are, approximately, + or - 4 percent. There were 11 distinct episodes during the past 250 million years. Sometimes appearing in pairs, the episodes have occurred quasi-periodically with a mean cycle time of 32 + or - 1 (estimated error of the mean) million years. The initiation dates of the episodes are close to the estimated dates of mass extinctions of marine organisms. Showers of impacting comets may be the cause.

  9. Remote (250 km Fiber Bragg Grating Multiplexing System

    Directory of Open Access Journals (Sweden)

    Manuel Lopez-Amo

    2011-09-01

    Full Text Available We propose and demonstrate two ultra-long range fiber Bragg grating (FBG sensor interrogation systems. In the first approach four FBGs are located 200 km from the monitoring station and a signal to noise ratio of 20 dB is obtained. The second improved version is able to detect the four multiplexed FBGs placed 250 km away, offering a signal to noise ratio of 6–8 dB. Consequently, this last system represents the longest range FBG sensor system reported so far that includes fiber sensor multiplexing capability. Both simple systems are based on a wavelength swept laser to scan the reflection spectra of the FBGs, and they are composed by two identical-lengths optical paths: the first one intended to launch the amplified laser signal by means of Raman amplification and the other one is employed to guide the reflection signal to the reception system.

  10. Bayesian demography 250 years after Bayes.

    Science.gov (United States)

    Bijak, Jakub; Bryant, John

    2016-01-01

    Bayesian statistics offers an alternative to classical (frequentist) statistics. It is distinguished by its use of probability distributions to describe uncertain quantities, which leads to elegant solutions to many difficult statistical problems. Although Bayesian demography, like Bayesian statistics more generally, is around 250 years old, only recently has it begun to flourish. The aim of this paper is to review the achievements of Bayesian demography, address some misconceptions, and make the case for wider use of Bayesian methods in population studies. We focus on three applications: demographic forecasts, limited data, and highly structured or complex models. The key advantages of Bayesian methods are the ability to integrate information from multiple sources and to describe uncertainty coherently. Bayesian methods also allow for including additional (prior) information next to the data sample. As such, Bayesian approaches are complementary to many traditional methods, which can be productively re-expressed in Bayesian terms.

  11. 40 CFR 1065.250 - Nondispersive infra-red analyzer.

    Science.gov (United States)

    2010-07-01

    ... analyzer that has compensation algorithms that are functions of other gaseous measurements and the engine's known or assumed fuel properties. The target value for any compensation algorithm is 0.0% (that is,...

  12. MicroRNA-132 Interact with p250GAP/Cdc42 Pathway in the Hippocampal Neuronal Culture Model of Acquired Epilepsy and Associated with Epileptogenesis Process

    Science.gov (United States)

    Huang, Hao; Zhou, Xin; Liu, Xi; Xu, Tao; Ma, Limin

    2016-01-01

    Increasing evidence suggests that epilepsy is the result of synaptic reorganization and pathological excitatory loop formation in the central nervous system; however, the mechanisms that regulate this process are not well understood. We proposed that microRNA-132 (miR-132) and p250GAP might play important roles in this process by activating the downstream Rho GTPase family. We tested this hypothesis using a magnesium-free medium-induced epileptic model of cultured hippocampal neurons. We investigated whether miR-132 regulates GTPase activity through p250GAP and found that Cdc42 was significantly activated in our experimental model. Silencing miR-132 inhibited the electrical excitability level of cultured epileptic neurons, whereas silencing p250GAP had an opposite effect. In addition, we verified the effect of miR-132 in vivo and found that silencing miR-132 inhibited the aberrant formation of dendritic spines and chronic spontaneous seizure in a lithium-pilocarpine-induced epileptic mouse model. Finally, we confirmed that silencing miR-132 has a neuroprotective effect on cultured epileptic neurons; however, this effect did not occur through the p250GAP pathway. Generally, silencing miR-132 may suppress spontaneous seizure activity through the miR-132/p250GAP/Cdc42 pathway by regulating the morphology and electrophysiology of dendritic spines; therefore, miR-132 may serve as a potential target for the development of antiepileptic drugs.

  13. MicroRNA-132 Interact with p250GAP/Cdc42 Pathway in the Hippocampal Neuronal Culture Model of Acquired Epilepsy and Associated with Epileptogenesis Process.

    Science.gov (United States)

    Yuan, Jinxian; Huang, Hao; Zhou, Xin; Liu, Xi; Ou, Shu; Xu, Tao; Li, Ruohan; Ma, Limin; Chen, Yangmei

    2016-01-01

    Increasing evidence suggests that epilepsy is the result of synaptic reorganization and pathological excitatory loop formation in the central nervous system; however, the mechanisms that regulate this process are not well understood. We proposed that microRNA-132 (miR-132) and p250GAP might play important roles in this process by activating the downstream Rho GTPase family. We tested this hypothesis using a magnesium-free medium-induced epileptic model of cultured hippocampal neurons. We investigated whether miR-132 regulates GTPase activity through p250GAP and found that Cdc42 was significantly activated in our experimental model. Silencing miR-132 inhibited the electrical excitability level of cultured epileptic neurons, whereas silencing p250GAP had an opposite effect. In addition, we verified the effect of miR-132 in vivo and found that silencing miR-132 inhibited the aberrant formation of dendritic spines and chronic spontaneous seizure in a lithium-pilocarpine-induced epileptic mouse model. Finally, we confirmed that silencing miR-132 has a neuroprotective effect on cultured epileptic neurons; however, this effect did not occur through the p250GAP pathway. Generally, silencing miR-132 may suppress spontaneous seizure activity through the miR-132/p250GAP/Cdc42 pathway by regulating the morphology and electrophysiology of dendritic spines; therefore, miR-132 may serve as a potential target for the development of antiepileptic drugs. PMID:27579184

  14. Targeted Learning

    CERN Document Server

    van der Laan, Mark J

    2011-01-01

    The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the targe

  15. Shock compression response of forsterite above 250 GPa.

    Science.gov (United States)

    Sekine, Toshimori; Ozaki, Norimasa; Miyanishi, Kohei; Asaumi, Yuto; Kimura, Tomoaki; Albertazzi, Bruno; Sato, Yuya; Sakawa, Youichi; Sano, Takayoshi; Sugita, Seiji; Matsui, Takafumi; Kodama, Ryosuke

    2016-08-01

    Forsterite (Mg2SiO4) is one of the major planetary materials, and its behavior under extreme conditions is important to understand the interior structure of large planets, such as super-Earths, and large-scale planetary impact events. Previous shock compression measurements of forsterite indicate that it may melt below 200 GPa, but these measurements did not go beyond 200 GPa. We report the shock response of forsterite above ~250 GPa, obtained using the laser shock wave technique. We simultaneously measured the Hugoniot and temperature of shocked forsterite and interpreted the results to suggest the following: (i) incongruent crystallization of MgO at 271 to 285 GPa, (ii) phase transition of MgO at 285 to 344 GPa, and (iii) remelting above ~470 to 500 GPa. These exothermic and endothermic reactions are seen to occur under extreme conditions of pressure and temperature. They indicate complex structural and chemical changes in the system MgO-SiO2 at extreme pressures and temperatures and will affect the way we understand the interior processes of large rocky planets as well as material transformation by impacts in the formation of planetary systems. PMID:27493993

  16. Grammaire pour adolescents 250 exercices : niveau débutant

    CERN Document Server

    Bié, Nathalie

    2005-01-01

    Ce nouveau livre d'exercices de grammaire, de la collection Le Nouvel Entraînez-vous, s'adresse à un public d'adolescents débutants et faux débutants en français langue étrangère. L'ouvrage propose 250 exercices de compréhension et de mémorisation à travers des activités de déduction et de réemploi des notions grammaticales étudiées. Le contenu des exercices est organisé autour de contextes langagiers proches de la réalité des adolescents afin de placer la communication au cœur de l'apprentissage. L'introduction des contenus grammaticaux suit la même progression que les méthodes usuelles. Chaque chapitre débute par une séquence Rappel permettant à l'apprenant de revoir rapidement les règles grammaticales développées dans les exercices. Chaque exercice est introduit par une consigne brève et concise accompagnée d'un exemple. L'ouvrage a été conçu en tenant compte des centres d'intérêts des adolescents et propose de nombreuses illustrations intégrées aux exercices. A la fin d...

  17. The Undergraduate ALFALFA Team: Outcomes for Over 250 Undergraduate Participants

    Science.gov (United States)

    Troischt, Parker; Koopmann, Rebecca A.; Haynes, Martha P.; ALFALFA Team

    2016-01-01

    The NSF-sponsored Undergraduate ALFALFA (Arecibo Legacy Fast ALFA) Team (UAT) is a consortium of 19 institutions founded to promote undergraduate research and faculty development within the extragalactic ALFALFA HI blind survey project and follow-up programs. In this talk we present outcomes for the more than 250 undergraduate students who have who have participated in the program during the 8 years of funding. 40% of these students have been women and members of underrepresented groups. To date 148 undergraduate students have attended annual workshops at Arecibo Observatory, interacting with faculty, graduate students, their peers, and Arecibo staff in lectures, group activities, tours, and observing runs. Team faculty have supervised 159 summer research projects and 120 academic year (e.g., senior thesis) projects. 68 students have traveled to Arecibo Observatory for observing runs and 55 have presented their results at national meetings such as the AAS. Through participation in the UAT, students are made aware of career paths they may not have previously considered. More than 90% of alumni are attending graduate school and/or pursuing a career in STEM. 42% of those pursuing graduate degrees in Physics or Astronomy are women. This work has been supported by NSF grants AST-0724918/0902211, AST-075267/0903394, AST-0725380, and AST-1211005

  18. Structural testing of the North Wind 250 composite rotor joint

    Science.gov (United States)

    Musial, W.; Link, H.; Coleman, C.

    1994-05-01

    The North Wind 250 wind turbine is under development at Northern Power Systems (NPS) in Moretown, VT. The turbine uses a unique, flow-through, teetered-rotor design. This design eliminates structural discontinuities at the blade/hub interface by fabricating the rotor as one continuous structural element. To accomplish this, the two blade spars are joined at the center of the rotor using a proprietary bonding technique. Fatigue tests were conducted on the full-scale rotor joint at the National Renewable Energy Laboratory (NREL). Subsequent tests are now underway to test the full-scale rotor and hub assembly to verify the design assumptions. The test articles were mounted in dedicated test fixtures. For the joint test, a constant moment was generated across the joint and parent material. Hydraulic actuators applied sinusoidal loading to the test article at levels equivalent to 90% of the extreme wind load for over one million cycles. When the loading was increased to 112% of the extreme wind load, the joint failed by buckling. Strain levels were monitored at 14 locations inside and outside of the blade joint during the test. The tests were used to qualify this critical element of the rotor for field testing and to provide information needed to improve the structural design of the joint.

  19. A family of doctors over 250 years: innovation and controversy.

    Science.gov (United States)

    Watkins, Peter J

    2011-05-01

    A family of Watkins doctors originating in the Northamptonshire town of Towcester included 13 doctors in seven generations during 250 years. In each generation there were between one and four doctors. Three doctors involved themselves actively in innovative yet controversial practises, described in their own writings and publications. Timothy Watkins' (1755-1834) own handwritten lecture notes describe the problems affecting an 18th-century man-midwife, while his accounts book provides insights into his lifestyle. The concept of the waterborne spread of cholera during the 1854 epidemic in Towcester is described by Robert Webb Watkins (1822-1901) during the same year as the observations made by John Snow (1813-58). John Webb Watkins (1833-1903) in his MD thesis (1856) describes his use of chloroform in labour in Towcester during the early 1850s, followed by self-experimentation with chloroform administered to him between 40 and 50 times by Sir James Young Simpson (1811-70) in Edinburgh. Descriptions of the two 19th-century general practitioners offer insights into the exemplary extent of their civic involvement in all walks of local community life, and of their family ties. PMID:21558531

  20. Shock compression response of forsterite above 250 GPa

    Science.gov (United States)

    Sekine, Toshimori; Ozaki, Norimasa; Miyanishi, Kohei; Asaumi, Yuto; Kimura, Tomoaki; Albertazzi, Bruno; Sato, Yuya; Sakawa, Youichi; Sano, Takayoshi; Sugita, Seiji; Matsui, Takafumi; Kodama, Ryosuke

    2016-01-01

    Forsterite (Mg2SiO4) is one of the major planetary materials, and its behavior under extreme conditions is important to understand the interior structure of large planets, such as super-Earths, and large-scale planetary impact events. Previous shock compression measurements of forsterite indicate that it may melt below 200 GPa, but these measurements did not go beyond 200 GPa. We report the shock response of forsterite above ~250 GPa, obtained using the laser shock wave technique. We simultaneously measured the Hugoniot and temperature of shocked forsterite and interpreted the results to suggest the following: (i) incongruent crystallization of MgO at 271 to 285 GPa, (ii) phase transition of MgO at 285 to 344 GPa, and (iii) remelting above ~470 to 500 GPa. These exothermic and endothermic reactions are seen to occur under extreme conditions of pressure and temperature. They indicate complex structural and chemical changes in the system MgO-SiO2 at extreme pressures and temperatures and will affect the way we understand the interior processes of large rocky planets as well as material transformation by impacts in the formation of planetary systems. PMID:27493993

  1. Bionics by examples 250 scenarios from classical to modern times

    CERN Document Server

    Nachtigall, Werner

    2015-01-01

    Bionics means learning from the nature for the development of technology. The science of "bionics" itself is classified into several sections, from materials and structures over procedures and processes until evolution and optimization. Not all these areas, or only a few, are really known in the public and also in scientific literature. This includes the Lotus-effect, converted to the contamination-reduction of fassades and the shark-shed-effect, converted to the  resistance-reduction of airplanes. However, there are hundreds of highly interesting examples that contain the transformation of principles of the nature into technology. From the large number of these examples, 250 were selected for the present book according to "prehistory", "early-history", "classic" and "modern time". Most examples are new. Every example includes a printed page in a homogeneous arrangement. The examples from the field "modern time" are joint in blocks corresponding to the sub-disciplines of bionics.

  2. Evaluation of some aspects of the VITROS 250 Bio-Chemistry analyzer%VITROS 250全自动干化学分析仪的评价

    Institute of Scientific and Technical Information of China (English)

    林有东; 蔡鹏威

    2006-01-01

    目的 评价美国强生VITROS 250全自动干化学分析仪器.方法 运用相关统计学方法对VITROS 250全自动干化学分析仪的精密度、相关性、抗胆红素干扰方面进行分析.结果 VITROS 250全自动干化学分析仪精密度高,回收率高,相关性好,抗干扰能力强.结论 VITROS 250全自动干化学分析仪适用于临床实验诊断中心(检验科)急诊化验室生化项目的检测.

  3. Widespread dual targeting of proteins in land plants: When, where, how and why

    OpenAIRE

    Carrie, Chris; Whelan, James

    2013-01-01

    Since the discovery of the first dual targeted protein in plants in 1995 the number of dual targeted proteins in plants has grown to over 250 proteins. Much work and investigations have focused on identifying how or what makes a protein dual targeted. Recently, more research has focused on the evolution and conservation of dual targeting of proteins in plants. This new work has demonstrated that dual targeting arose early within the evolution of plants and because it is rarely lost, once gain...

  4. Study of solar features causing GMSs with 250 < < 400

    Indian Academy of Sciences (India)

    Santosh Kumar; Mahendra Pratap Yadav

    2003-07-01

    The effect of solar features on geospheric conditions leading to geomagnetic storms (GMSs) with planetary index, p ≥ 20 and the range of horizontal component of the Earth’s magnetic field such that 250 < < 400 has been investigated using interplanetary magnetic field (IMF), solar wind plasma (SWP) and solar geophysical data (SGD) during the period 1978–99. Statistically, it is observed that maximum number of GMSs have occurred during the maximum solar activity years of 21st and 22nd solar cycles. A peculiar result has been observed during the years 1982, 1994 when sunspot numbers (SSNs) decrease very rapidly while numbers of GMSs increase. No distinct association between yearly occurrence of disturbed days and SSNs is observed. Maximum number of disturbed days have occurred during spring and rainy seasons showing a seasonal variation of disturbed days. No significant correlation between magnitude (intensity) of GMSs and importance of , X-ray solar flares has been observed. Maximum number of GMSs is associated with solar flares of lower importance, i.e., SF during the period 1978–93. , X-ray solar flares occurred within lower helio-latitudes, i.e., (0–30)°N to (0–30)°S are associated with GMSs. No , X-ray solar flares have occurred beyond 40°N or 40°S in association with GMSs. In helio-latitude range (10–40)°N to (10–40)°S, the 89.5% concentration of active prominences and disappearing filaments (APDFs) are associated with GMSs. Maximum number of GMSs are associated with solar flares. Coronal mass ejections (CMEs) are related with eruptive prominences, solar flares, type IV radio burst and they occur at low helio-latitude. It is observed that CMEs related GMS events are not always associated with high speed solar wind streams (HSSWSs). In many individual events, the travel time between the explosion on the Sun and maximum activity lies between 58 and 118 h causing GMSs at the Earth.

  5. Hydrological variability in northern Levant over the past 250 ka

    Directory of Open Access Journals (Sweden)

    F. Gasse

    2011-05-01

    Full Text Available The Levant features sharp climatic gradients from North to South and from West to East resulting in a large environmental diversity. The lack of long-term record from the northern Levant limits our understanding of the regional response to glacial-interglacial boundary conditions in this key area. The 250 ka paleoenvironmental reconstruction presented here is a first step to fill this geographical gap.

    The record comes from a 36 m lacustrine-palustrine sequence cored in the small intra-mountainous karstic basin of Yammoûneh (northern Lebanon. The paper combines times series of sediment properties, paleovegetation, and carbonate oxygen isotopes, to yield a comprehensive view of paleohydrologic-paleoclimatic fluctuations in the basin over the two last glacial-interglacial cycles. Efficient moisture was higher than today during interglacial peaks around 240, 215–220, ~130–120 ka and 11–9 ka (although under different Precipitation minus Evaporation balance. Moderate wetting events took place around 170, 150, 105–100, 85–75, 60–55 and 35 ka. The penultimate glacial period was generally wetter than the last glacial stage. Local aridity culminated from the LGM to 15 ka, possibly linked to water storage as ice in the surrounding highlands. An overall decrease in local water availability is observed from the profile base to top. Fluctuations in available water seem to be primarily governed by changes in local summer insolation controlled by the orbital eccentricity modulated by the precession cycle, and by changes in precipitation and temperature seasonality.

    Our record is roughly consistent with long-term climatic fluctuations in northeastern Mediterranean lands, except during the penultimate glacial phase. It shares some features with speleothem records of western Israel. Conversely, after 130 ka, it is clearly out of phase with hydrological changes in the Dead Sea basin. Potential causes of these spatial heterogeneities

  6. 30 CFR 250.192 - What reports and statistics must I submit relating to a hurricane, earthquake, or other natural...

    Science.gov (United States)

    2010-07-01

    ... submitting your statistics by fax or e-mail, you may submit them electronically in accordance with 30 CFR 250... electronically in accordance with 30 CFR 250.186(a)(3). In the report, you must: (i) Name the items damaged (e.g... relating to a hurricane, earthquake, or other natural occurrence? 250.192 Section 250.192 Mineral...

  7. 41 CFR 60-250.70 - Disputed matters related to compliance with the Act.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Disputed matters related to compliance with the Act. 60-250.70 Section 60-250.70 Public Contracts and Property Management... SEPARATED VETERANS, AND OTHER PROTECTED VETERANS General Enforcement and Complaint Procedures §...

  8. 7 CFR 250.59 - Storage and inventory management of donated foods.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Storage and inventory management of donated foods. 250... National School Lunch Program (NSLP) and Other Child Nutrition Programs § 250.59 Storage and inventory management of donated foods. (a) General requirements. Distributing agencies, subdistributing agencies,...

  9. 30 CFR 250.1506 - How often must I train my employees?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How often must I train my employees? 250.1506... Training § 250.1506 How often must I train my employees? You determine the frequency of the training you provide your employees. You must do all of the following: (a) Provide periodic training to ensure...

  10. 30 CFR 250.1505 - Where may I get training for my employees?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Where may I get training for my employees? 250... Safety Training § 250.1505 Where may I get training for my employees? You may get training from any source that meets the requirements of your training plan....

  11. 30 CFR 250.410 - How do I obtain approval to drill a well?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I obtain approval to drill a well? 250... OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.410 How do I obtain approval to drill a well? You must obtain...

  12. 12 CFR 250.403 - Service of member bank and real estate investment company.

    Science.gov (United States)

    2010-01-01

    ... Board took the position that a closed-end investment company which was in process of organization and... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Service of member bank and real estate investment company. 250.403 Section 250.403 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD...

  13. 30 CFR 250.444 - What are the choke manifold requirements?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the choke manifold requirements? 250... Blowout Preventer (bop) System Requirements § 250.444 What are the choke manifold requirements? (a) Your BOP system must include a choke manifold that is suitable for the anticipated surface...

  14. 45 CFR 286.250 - What definitions apply to this subpart?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false What definitions apply to this subpart? 286.250 Section 286.250 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL TANF PROVISIONS Data Collection...

  15. 41 CFR 60-250.25 - Health insurance, life insurance and other benefit plans.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Health insurance, life insurance and other benefit plans. 60-250.25 Section 60-250.25 Public Contracts and Property Management..., life insurance and other benefit plans. (a) An insurer, hospital, or medical service company,...

  16. 30 CFR 250.455 - What are the general requirements for a drilling fluid program?

    Science.gov (United States)

    2010-07-01

    ... well control. This program must address drilling fluid safe practices, testing and monitoring equipment... drilling fluid program? 250.455 Section 250.455 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil...

  17. 30 CFR 250.424 - What are the requirements for prolonged drilling operations?

    Science.gov (United States)

    2010-07-01

    ... the prolonged operations on continued drilling operations and the life of the well. At a minimum, you... drilling operations? 250.424 Section 250.424 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and...

  18. 30 CFR 250.1160 - When may I flare or vent gas?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When may I flare or vent gas? 250.1160 Section..., Venting, and Burning Hydrocarbons § 250.1160 When may I flare or vent gas? (a) You must request and receive approval from the Regional Supervisor to flare or vent natural gas at your facility, except in...

  19. 12 CFR 250.400 - Service of open-end investment company.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Service of open-end investment company. 250.400 Section 250.400 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL....400 Service of open-end investment company. An open-end investment company is defined in section...

  20. 41 CFR Appendix A to Part 61 - 250-Federal Contractor Veterans' Employment Report VETS-100

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true 250-Federal Contractor Veterans' Employment Report VETS-100 A Appendix A to Part 61 Public Contracts and Property Management Other... Appendix A to Part 61-250—Federal Contractor Veterans' Employment Report VETS-100 ER05NO08.000...

  1. 30 CFR 250.908 - What are the minimum structural fatigue design requirements?

    Science.gov (United States)

    2010-07-01

    ... Platform Approval Program § 250.908 What are the minimum structural fatigue design requirements? (a) API RP 2A-WSD, Recommended Practice for Planning, Designing and Constructing Fixed Offshore Platforms (incorporated by reference as specified in 30 CFR 250.198), requires that the design fatigue life of each...

  2. 30 CFR 250.1629 - Additional production and fuel gas system requirements.

    Science.gov (United States)

    2010-07-01

    ... systems must conform to subsection 5.2, Fire Water Systems, of API RP 14G, Recommended Practice for Fire... as specified in 30 CFR 250.198). Pressure and fired vessels must have maintenance inspection, rating.../ASME Boiler and Pressure Vessel Code (incorporated by reference as specified in 30 CFR 250.198)....

  3. 48 CFR 250.104-3 - Special procedures for unusually hazardous or nuclear risks.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Special procedures for unusually hazardous or nuclear risks. 250.104-3 Section 250.104-3 Federal Acquisition Regulations System... unusually hazardous or nuclear risks....

  4. 40 CFR 436.250 - Applicability; description of the jade subcategory.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Applicability; description of the jade subcategory. 436.250 Section 436.250 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS MINERAL MINING AND PROCESSING POINT SOURCE CATEGORY Jade...

  5. 30 CFR 250.1752 - How do I remove a pipeline?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I remove a pipeline? 250.1752 Section... GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Decommissioning Activities Pipeline Decommissioning § 250.1752 How do I remove a pipeline? Before removing a pipeline, you must: (a) Submit a...

  6. 21 CFR 107.250 - Termination of an infant formula recall.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Termination of an infant formula recall. 107.250... (CONTINUED) FOOD FOR HUMAN CONSUMPTION INFANT FORMULA Infant Formula Recalls § 107.250 Termination of an infant formula recall. The recalling firm may submit a recommendation for termination of the recall...

  7. 32 CFR 250.7 - Pertinent portions of Export Administration Regulations (EAR).

    Science.gov (United States)

    2010-07-01

    ... technical data under the authority of this part. Export Administration Regulations 15 CFR 379.3 General... accordance with the regulations of the Patent and Trademark Office 37 CFR part 5. See § 370.10(j).) ... Regulations (EAR). 250.7 Section 250.7 National Defense Department of Defense (Continued) OFFICE OF...

  8. Soil property maps of Africa at 250 m resolution

    Science.gov (United States)

    Kempen, Bas; Hengl, Tomislav; Heuvelink, Gerard B. M.; Leenaars, Johan G. B.; Walsh, Markus G.; MacMillan, Robert A.; Mendes de Jesus, Jorge S.; Shepherd, Keith; Sila, Andrew; Desta, Lulseged T.; Tondoh, Jérôme E.

    2015-04-01

    Vast areas of arable land in sub-Saharan Africa suffer from low soil fertility and physical soil constraints, and significant amounts of nutrients are lost yearly due to unsustainable soil management practices. At the same time it is expected that agriculture in Africa must intensify to meet the growing demand for food and fiber the next decades. Protection and sustainable management of Africa's soil resources is crucial to achieve this. In this context, comprehensive, accurate and up-to-date soil information is an essential input to any agricultural or environmental management or policy and decision-making model. In Africa, detailed soil information has been fragmented and limited to specific zones of interest for decades. To help bridge the soil information gap in Africa, the Africa Soil Information Service (AfSIS) project was established in 2008. AfSIS builds on recent advances in digital soil mapping, infrared spectroscopy, remote sensing, (geo)statistics, and integrated soil fertility management to improve the way soils are evaluated, mapped, and monitored. Over the period 2008-2014, the AfSIS project has compiled two soil profile data sets (about 28,000 unique locations): the Africa Soil Profiles (legacy) database and the AfSIS Sentinel Site (new soil samples) database -- the two data sets represent the most comprehensive soil sample database of the African continent to date. In addition a large set of high-resolution environmental data layers (covariates) was assembled. The point data were used in the AfSIS project to generate a set of maps of key soil properties for the African continent at 250 m spatial resolution: sand, silt and clay fractions, bulk density, organic carbon, total nitrogen, pH, cation-exchange capacity, exchangeable bases (Ca, K, Mg, Na), exchangeable acidity, and Al content. These properties were mapped for six depth intervals up to 2 m: 0-5 cm, 5-15 cm, 15-30 cm, 30-60 cm, 60-100 cm, and 100-200 cm. Random forests modelling was used to

  9. The expected radiation damage of CSNS target

    Science.gov (United States)

    Yin, W.; Yu, Q. Z.; Lu, Y. L.; Wang, S. L.; Tong, J. F.; Liang, T. J.

    2012-12-01

    The radiation damage to the tungsten target and its SS316 vessel for Chinese Spallation Neutron Source (CSNS) has been estimated with a Monte-Carlo simulation code MCNPX2.5.0. We compare the effects on the radiation damage due to two different proton beam profiles: a uniform distribution and a Gaussian distribution. We also discuss the dependence of the radiation damage estimation on different physics models. The results show the peak displacement productions in vessel and the fourth target plate are 2.5 and 5.5 dpa/y, respectively, under a Gaussian proton beam. The peak helium productions in the vessel and the fourth target are 305 and 353 appm/y, respectively, under the same proton beam. Based on these results and the allowable dpa values we have estimated the lifetime of the tungsten target and its vessel.

  10. The expected radiation damage of CSNS target

    Energy Technology Data Exchange (ETDEWEB)

    Yin, W., E-mail: wenyin@aphy.iphy.ac.cn [Engineering Center of CSNS Target Station and Instruments, Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China); Yu, Q.Z. [Engineering Center of CSNS Target Station and Instruments, Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China); Lu, Y.L.; Wang, S.L.; Tong, J.F. [Experimental System of CSNS, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Liang, T.J. [Engineering Center of CSNS Target Station and Instruments, Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China)

    2012-12-15

    The radiation damage to the tungsten target and its SS316 vessel for Chinese Spallation Neutron Source (CSNS) has been estimated with a Monte-Carlo simulation code MCNPX2.5.0. We compare the effects on the radiation damage due to two different proton beam profiles: a uniform distribution and a Gaussian distribution. We also discuss the dependence of the radiation damage estimation on different physics models. The results show the peak displacement productions in vessel and the fourth target plate are 2.5 and 5.5 dpa/y, respectively, under a Gaussian proton beam. The peak helium productions in the vessel and the fourth target are 305 and 353 appm/y, respectively, under the same proton beam. Based on these results and the allowable dpa values we have estimated the lifetime of the tungsten target and its vessel.

  11. Electron collisional detachment processes for a 250 keV D- ion beam in a partially ionized hydrogen target

    International Nuclear Information System (INIS)

    Neutral atom beams with energies above 200 keV may be required for various purposes in magnetic fusion devices following TFTR, JET and MFTF-B. These beams can be produced much more efficiently by electron detachment from negative ion beams than by electron capture by positive ions. We have investigated the efficiency with which such neutral atoms can be produced by electron detachment in partially ionized hydrogen plasma neutralizers

  12. Investigation of Fast Neutron Production by 100 to 250~GeV Muon Interactions on Thin Targets

    CERN Multimedia

    2002-01-01

    % NA55 \\\\ \\\\ The production of fast (1~MeV~-~1~GeV) neutrons in high energy muon-nucleon interactions is poorly understood. Yet it is essential to the understanding of the background in many underground neutrino experiments and, in particular, may hold relevance for the atmospheric neutrino anomaly. We propose an experiment to investigate fast neutron production using the M2 muon beam at the CERN SPS.

  13. The multiplicity of 250-$\\mu$m Herschel sources in the COSMOS field

    CERN Document Server

    Scudder, Jillian M; Hurley, Peter D; Griffin, Matt; Sargent, Mark T; Scott, Douglas; Wang, Lingyu; Wardlow, Julie L

    2016-01-01

    We investigate the multiplicity of extragalactic sources detected by the Herschel Space Observatory in the COSMOS field. Using 3.6- and 24-$\\mu$m catalogues, in conjunction with 250-$\\mu$m data from Herschel, we seek to determine if a significant fraction of Herschel sources are composed of multiple components emitting at 250 $\\mu$m. We use the XID+ code, using Bayesian inference methods to produce probability distributions of the possible contributions to the observed 250-$\\mu$m flux for each potential component. The fraction of Herschel flux assigned to the brightest component is highest for sources with total 250-$\\mu$m fluxes < 45 mJy; however, the flux in the brightest component is still highest in the brightest Herschel sources. The faintest 250-$\\mu$m sources (30-45 mJy) have the majority of their flux assigned to a single bright component; the second brightest component is typically significantly weaker, and contains the remainder of the 250-$\\mu$m source flux. At the highest 250-$\\mu$m fluxes (45-...

  14. Pulverização em CDA 250 herbicida pendimethalin na cultura do arroz de sequeiro Application of pendimethalin with cda 250 spfayer for upland rice

    Directory of Open Access Journals (Sweden)

    T. Matuo

    1984-01-01

    Full Text Available Foi estudada a viabilidade de utilização da pulverização CDA 25C, na aplicação do herbicida em pré-emergência na cultura do arroz de sequeiro. O herbicida empregado foi o pendimethalin nas doses de 0,0; 1,5; 2,0; 2,5 e 3,0 litro s/ha da formulação comercial a 50%. A pulverização convencional foi efetuada com bicos 11003 com consumo de 200 litros de calda per hectare. O processo CDA 250 foi aplicado por meio de bico rotativo (Micromax com dois níveis de consumo de calda : 50 1/ha e 27 1/ha. Os resultados mostraram que: a - o método CDA 250 proporciona controle dc mato e produtividade de arroz equivalentes ao método convencional; b para o bico Micromax, a aplicação da formulação comercial de pendimethalin a 50% com vazão de 0,48 1/min./bico, a distância entre bicos deve ser de 1,75 m e para a vazão de 0,96 1/min./bloco, essa distancia deve ser de 1,90 m; c- a aplicação do pendimethalin 50% C.E. pelo processo CDA 250, empregando 27 litros de calda por hectare foi o processo mais interessante por oferecer vantagens logísticas apreciáveis.The feasibility of pre-emergenge herbicide application for upland rice by CDA 250 spray method was studied. The herbicide used was pen dimethalin at 0,0; 1,5; 2,0; 2,5 and 3,0 1/ha of comercial 50% E.C. formulation. Conventional spraying was carried out using 110C3 flat fan nozzles applying 200 1/ha of spray volume CDA250 was applied by rotary atomizers (Micromax spraying twc volume rates: 50 1/ha and 27 1/ha. The results pointed out that: a- CDA 250 spray method was equivalent to the conventional spray method in the control of weeds and crop yield; b - for Micromax nozzles applying commercial 50 E.C. formulation of pendimethalin at 0,48 /min of nozzle feed rate, the distance between nozzles should be 1,75 m and at 0,96 1/min feed rate this distance shoud be 1,90 m; c- CDA 250, applying 27 1/ha presents large logistic advantages.

  15. 解读2015年度ENR国际承包商250强%Analysis on the ENR Top 250 International Contractors in 2015

    Institute of Scientific and Technical Information of China (English)

    张宇

    2015-01-01

    Based on the results of the ENR top 250 international Contractors in 2015,the analysis on the 250 international contractors was conducted from the revenue outside of their home countries,the profitability,the professional hiring,regional and market distribution in 2014. In the context of the global politics and economics environment,the highlights and trend of the development of international contracting market were concluded. On the contractors from mainland China in top 250,the number, influence and distribution were emphasized and the comparison from the last 5 years was done both on the mainland Chinese contractors and the top 10 international contractors. By the evaluation on the performance of the 250 international contractors and the discuss on the international engineering market,the recognition on the global competition of the contractors in mainland China would be promoted and their improvement in international contracting market could get useful information.%以美国《工程新闻记录》发布的2015年度国际承包商250强榜单数据为基础,对进入榜单的250家承包商的海外市场收入总体规模、效益、专业技术人员雇佣、业务领域分布、区域性市场及所属国家或地区进行了剖析.结合近期国际经济政治环境,对国际承包市场发展特征及趋势进行了总结和概括.重点分析了本年度进入250强榜单的中国内地企业承包商的数量、影响和行业及地区分布,并对近5年中国内地企业的表现进行了对比分析,同时对近5年国际承包商10强的变化进行了梳理.通过对国际承包市场要素的分析及对主要承包商业绩的评价,为中国内地企业增强对国际竞争的认识,继续开拓国际工程承包市场提供基础信息支持.

  16. 1:250,000-scale geology of the Carson River Basin, Nevada and California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digital continuous geologic data for the Carson River Basin, Nevada and California. It was compiled from individual county 1:250,000-scale...

  17. 41 CFR 60-250.44 - Required contents of affirmative action programs.

    Science.gov (United States)

    2010-07-01

    ... the workplace. (See § 60-250.2(w) defining direct threat.) (d) Reasonable accommodation to physical... career days, youth motivation programs, and related activities in their communities. (6) The...

  18. 1:250,000-scale geology of the Dry Valley Hydrographic Area, Nevada and California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This dataset consists of digital geologic data for the Dry Valley Hydrographic area, Nevada and California. It was compiled from individual 1:250,000-scale geologic...

  19. The p250GAP Gene Is Associated with Risk for Schizophrenia and Schizotypal Personality Traits

    OpenAIRE

    Kazutaka Ohi; Ryota Hashimoto; Takanobu Nakazawa; Takeya Okada; Yuka Yasuda; Hidenaga Yamamori; Motoyuki Fukumoto; Satomi Umeda-Yano; Masao Iwase; Hiroaki Kazui; Tadashi Yamamoto; Masanobu Kano; Masatoshi Takeda

    2012-01-01

    BACKGROUND: Hypofunction of the glutamate N-Methyl-d-aspartate (NMDA) receptor has been implicated in the pathophysiology of schizophrenia. p250GAP is a brain-enriched NMDA receptor-interacting RhoGAP. p250GAP is involved in spine morphology, and spine morphology has been shown to be altered in the post-mortem brains of patients with schizophrenia. Schizotypal personality disorder has a strong familial relationship with schizophrenia. Several susceptibility genes for schizophrenia have been r...

  20. Snow Cover Maps from MODIS Images at 250 m Resolution, Part 2: Validation

    OpenAIRE

    Marc Zebisch; Christian Steurer; Armin Costa; Roberto Monsorno; Thomas Schellenberger; Anke Tetzlaff; Martial Duguay; Nico Moelg; Claudia Notarnicola

    2013-01-01

    The performance of a new algorithm for binary snow cover monitoring based on Moderate Resolution Imaging Spectroradiometer (MODIS) satellite images at 250 m resolution is validated using snow cover maps (SCA) based on Landsat 7 ETM+ images and in situ snow depth measurements from ground stations in selected test sites in Central Europe. The advantages of the proposed algorithm are the improved ground resolution of 250 m and the near real-time availability with respect to the 500 m standard Na...

  1. Galvanic corrosion behaviour of HE 20 / MDN 138 & HE 20 / MDN 250 alloys in natural seawater

    Science.gov (United States)

    Subramanian, G.; Parthiban, G. T.; Muthuraman, K.; Ramakrishna rao, P.

    2016-09-01

    In view of their excellent mechanical properties, workability and heat treatment characteristics, MDN 138 & MDN 250 have been widely used in missile, rocket and aerospace industries. With light weight and high performance characteristics HE 20 aluminium alloy acts as an important material in defence and aerospace applications. The galvanic corrosion behaviour of the metal combinations HE 20 / MDN 138 and HE 20 / MDN 250, with 1:1 area ratio, has been studied in natural seawater using the open well facility of CECRI's Offshore Platform at Tuticorin for a year. The open circuit potentials of MDN 138, MDN 250 and HE 20 of the individual metal, the mixed potential and galvanic current of the couples HE 20 / MDN 138 and HE 20 / MDN 250 were periodically monitored throughout the study period. The calcareous deposits on MDN 138 and MDN 250 were analysed using XRD. The results of the study reveal that that HE 20 has offered required amount of protection to MDN 138 & MDN 250.

  2. Transmission of the P250R mutation of the FGFR3 gene in four generations with highly variable phenotype

    DEFF Research Database (Denmark)

    Hove, Hanne Buciek; Dunø, Morten; Daugaard-Jensen, Jette;

    Transmission of the P250R mutation of the FGFR3 gene in four generations with highly variable phenotype.......Transmission of the P250R mutation of the FGFR3 gene in four generations with highly variable phenotype....

  3. 30 CFR 250.107 - What must I do to protect health, safety, property, and the environment?

    Science.gov (United States)

    2010-07-01

    ..., property, and the environment? 250.107 Section 250.107 Mineral Resources MINERALS MANAGEMENT SERVICE... Performance Standards § 250.107 What must I do to protect health, safety, property, and the environment? (a) You must protect health, safety, property, and the environment by: (1) Performing all operations in...

  4. 30 CFR 250.116 - How do I determine producibility if my well is in the Gulf of Mexico?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I determine producibility if my well is in the Gulf of Mexico? 250.116 Section 250.116 Mineral Resources MINERALS MANAGEMENT SERVICE... Performance Standards § 250.116 How do I determine producibility if my well is in the Gulf of Mexico? If...

  5. 30 CFR 250.103 - Where can I find more information about the requirements in this part?

    Science.gov (United States)

    2010-07-01

    ... requirements in this part? 250.103 Section 250.103 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF General Authority and Definition of Terms § 250.103 Where can I find more information about the requirements in...

  6. 30 CFR 250.1006 - How must I decommission and take out of service a DOI pipeline?

    Science.gov (United States)

    2010-07-01

    ... a DOI pipeline? 250.1006 Section 250.1006 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Pipelines and Pipeline Rights-of-Way § 250.1006 How must I decommission and take out of service a DOI...

  7. 17 CFR 250.12 - Exemption of certain public utility companies from the definition of subsidiary companies of...

    Science.gov (United States)

    2010-04-01

    ... utility companies from the definition of subsidiary companies of holding companies. 250.12 Section 250.12... REGULATIONS, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 Registration and General Exemptions § 250.12 Exemption of certain public utility companies from the definition of subsidiary companies of holding...

  8. 30 CFR 250.260 - What Coastal Zone Management Act (CZMA) information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ...) information must accompany the DPP or DOCD? 250.260 Section 250.260 Mineral Resources MINERALS MANAGEMENT... Operations Coordination Documents (docd) § 250.260 What Coastal Zone Management Act (CZMA) information must.... “Information” as required by 15 CFR 930.76(a) and 15 CFR 930.58(a)(2)) and “Analysis” as required by 15 CFR...

  9. Digitalna topografska karta 1:250 000 - prema NATO standardima / Digital 1:250 000 topographic map designed in accordance with NATO standards

    Directory of Open Access Journals (Sweden)

    Mirko Borisov

    2007-10-01

    Full Text Available U radu se iznose iskustva pri izradi i oblikovanju vojne topografske karte razmera 1: 250 000. Karta se izrađuje u Vojnogeografskom institutu, po NATO standardima i u digitalnom obliku. Iskustva drugih država u kreiranju vojnih topografsko-kartografskih sistema i karata mogu se uporediti sa našim. Postupci izrade i ažuriranja vojnih topografskih karata su informatički podržani uz veliki stepen automatizacije pojedinih faza njihove izrade i osavremenjavanja. / The paper presents the design of the 1:250 000 military topographic map in the Military Geographical Institute (MGI in accordance with NATO standards and in a digital form. Other states' experiences in designing military topographic and cartographic systems and maps can be compared with those of the MGI's. The procedures of producing and updating military topographic maps are computer aided while particular phases are automated to a great extent.

  10. The case for a generic phytosanitary irradiation dose of 250 Gy for Lepidoptera eggs and larvae

    International Nuclear Information System (INIS)

    The literature on ionizing irradiation of Lepidoptera is critically examined for a dose that could serve as a generic phytosanitary treatment for all eggs and larvae of that order, which contains many quarantine pests that inhibit trade in fresh agricultural commodities. The measure of efficacy used in deriving this dose is the prevention of emergence of normal-looking adults that are assumed not able to fly. A dose of 250 Gy is supported by many studies comprising 34 species in 11 lepidopteran families, including those of significant quarantine importance. Two studies with two different species found that doses >250 Gy were necessary, but both of these are contradicted by other studies showing that 10,000 individuals) testing for families other than Tortricidae (the most important quarantine family in the Lepidoptera). Because several large-scale studies have been done with tortricids a dose of 250 Gy could be justifiable for Tortricidae if it is not acceptable for the entire Lepidoptera at this time. - Highlights: • A radiation dose of 250 Gy is suggested as a generic phytosanitary treatment for Lepidoptera larvae. • The dose of 250 Gy is especially supported for the family Tortricidae. • The endpoint is prevention of normal-looking adults, assumed not able to fly or reproduce

  11. The faint end of the 250 micron luminosity function at z < 0.5

    CERN Document Server

    Wang, L; Bethermin, M; Bourne, N; Cooray, A; Cowley, W; Dunne, L; Dye, S; Eales, S; Farrah, D; Lacey, C; Loveday, J; Maddox, S; Oliver, S; Viero, M

    2016-01-01

    Aims. We aim to study the 250 micron luminosity function (LF) down to much fainter luminosities than achieved by previous efforts. Methods. We developed a modified stacking method to reconstruct the 250 micron LF using optically selected galaxies from the SDSS survey and Herschel maps of the GAMA equatorial fields and Stripe 82. Our stacking method not only recovers the mean 250 micron luminosities of galaxies that are too faint to be individually detected, but also their underlying distribution functions. Results. We find very good agreement with previous measurements in the overlapping luminosity range. More importantly, we are able to derive the LF down to much fainter luminosities (around 25 times fainter) than achieved by previous studies. We find strong positive luminosity evolution \\propto (1 + z)^4.89\\pm1.07 and moderate negative density evolution \\propto (1 + z)^-1.02\\pm0.54 over the redshift range z=[0.02, 0.5].

  12. Influence of solution cooling rate on austenite content of C250 steel%固溶冷却速率对C250钢奥氏体含量的影响

    Institute of Scientific and Technical Information of China (English)

    李伟

    2011-01-01

    试验了固溶冷却速率对C250钢奥氏体含量影响。试验结果表明,C250钢没有热稳定化现象,固溶后甚至缓慢冷却,也不会产生残留奥氏体。但固溶后缓慢冷却,再经时效强化处理,C250钢中将产生逆转变奥氏体,固溶冷却越缓慢,时效后的逆转变奥氏体量越多。C250钢固溶后空冷+485℃时效处理状态的没有奥氏体。%Influence of solution cooling rate on austenite content of C250 steel was investigated.The results show that there is no retained austenite in C250 steel solution treated even with very slowly cooling rate,and no austenite thermal stabilization phenomenon exists in C250 steel.But there is some reverted austenite in C250 steel aged when the solution cooling rate is very slow.The slower the solution cooling rate,the higher the content of reverted austenite in C250 steel aged.There is no reverted austenite in C250 steel solution treated with air cooling and aged at 485 ℃.

  13. The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits.

    Directory of Open Access Journals (Sweden)

    Kazutaka Ohi

    Full Text Available BACKGROUND: Hypofunction of the glutamate N-Methyl-d-aspartate (NMDA receptor has been implicated in the pathophysiology of schizophrenia. p250GAP is a brain-enriched NMDA receptor-interacting RhoGAP. p250GAP is involved in spine morphology, and spine morphology has been shown to be altered in the post-mortem brains of patients with schizophrenia. Schizotypal personality disorder has a strong familial relationship with schizophrenia. Several susceptibility genes for schizophrenia have been related to schizotypal traits. METHODS: We first investigated the association of eight linkage disequilibrium-tagging single-nucleotide polymorphisms (SNPs that cover the p250GAP gene with schizophrenia in a Japanese sample of 431 schizophrenia patients and 572 controls. We then investigated the impact of the risk genetic variant in the p250GAP gene on schizotypal personality traits in 180 healthy subjects using the Schizotypal Personality Questionnaire. RESULTS: We found a significant difference in genotype frequency between the patients and the controls in rs2298599 (χ(2 = 17.6, p = 0.00015. The minor A/A genotype frequency of rs2298599 was higher in the patients (18% than in the controls (9% (χ(2 = 15.5, p = 0.000083. Moreover, we found that subjects with the rs2298599 risk A/A genotype, compared with G allele carriers, had higher scores of schizotypal traits (F(1,178 = 4.08, p = 0.045, particularly the interpersonal factor (F(1,178 = 5.85, p = 0.017. DISCUSSION: These results suggest that a genetic variation in the p250GAP gene might increase susceptibility not only for schizophrenia but also for schizotypal personality traits. We concluded that the p250GAP gene might be a new candidate gene for susceptibility to schizophrenia.

  14. Making Planet Nine: Pebble Accretion at 250--750 AU in a Gravitationally Unstable Ring

    CERN Document Server

    Kenyon, Scott J

    2016-01-01

    We investigate the formation of icy super-Earth mass planets within a gravitationally unstable ring of solids orbiting at 250-750 AU around a 1 solar mass star. Coagulation calculations demonstrate that a system of a few large oligarchs and a swarm of pebbles generates a super-Earth within 100-200 Myr at 250 AU and within 1-2 Gyr at 750 AU. Systems with more than ten oligarchs fail to yield super-Earths over the age of the solar system. As these systems evolve, destructive collisions produce detectable debris disks with luminosities of $10^{-5}$ to $10^{-3}$ relative to the central star.

  15. Digitalna topografska karta 1:250 000 - prema NATO standardima / Digital 1:250 000 topographic map designed in accordance with NATO standards

    OpenAIRE

    Mirko Borisov

    2007-01-01

    U radu se iznose iskustva pri izradi i oblikovanju vojne topografske karte razmera 1: 250 000. Karta se izrađuje u Vojnogeografskom institutu, po NATO standardima i u digitalnom obliku. Iskustva drugih država u kreiranju vojnih topografsko-kartografskih sistema i karata mogu se uporediti sa našim. Postupci izrade i ažuriranja vojnih topografskih karata su informatički podržani uz veliki stepen automatizacije pojedinih faza njihove izrade i osavremenjavanja. / The paper presents the design of ...

  16. 未足月胎膜早破250例临床分析%Clinical analysis of preterm premature rupture of membranes 250 cases

    Institute of Scientific and Technical Information of China (English)

    季美芳

    2011-01-01

    Objective To analyze the incidence of preterm premature rupture of membranes causes and clinical treatment. Methods A retrospective analysis of January 2005 - December 2010 in our hospital the 250 patients clinical data with premature rupture of membranes at term. Results PPROM than in the composition of the relevant factors, reproductive tract infections up to 24.4% , followed by 22% fetal abnormalities, miscarriage, abortion history of 18. 8% ; 250 cases of vaginal delivery in patients with PPROM 112 cases, 44. 8% ; cesarean section in 138 cases, accounting for 55. 2% ; pregnant 28 to 31+6 weeks of the cesarean section rate of less than 32 to 34 pregnant and pregnant 6 weeks 35 to 36+6 weeks (P 0. 05). Conclusions For <34 weeks gestation PPROM prenatal tocolytic, glucocor-ticoids promote fetal lung maturity and antibiotics to prevent infections intervention to extend the gesta-tional age, to reduce perinatal complications and increase survival rate.%目的 分析研究未足月胎膜早破(PPROM)的发生原因以及临床处理方法.方法 回顾性分析2005年1月至2010年12月期间在本院住院治疗的250例未足月胎膜早破患者的临床资料.结果 PPROM相关因素的构成比中,生殖道感染最高24.4%,其次为胎位异常22%,流产、引产史18.8%;250例PPROM患者中阴道分娩112例,占44.8%;剖宫产138例,占55.2%;孕28 ~31+6周组的剖宫产率低于孕32 ~34+6周组和孕35 ~36+6周组(P<0.05);而孕32 ~34+6周组与孕35~36+6周组比较,无统计学意义(P>0.05).结论 对于小于34孕周的PPROM产前使用宫缩抑制剂、糖皮质激素促胎肺成熟及抗生素预防感染等于预,可延长孕龄,减少围产儿并发症,增加成活率.

  17. 17 CFR 250.103A - Liability for certain statements by issuers.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Liability for certain... Miscellaneous Rules § 250.103A Liability for certain statements by issuers. (a) A statement within the coverage... oil and gas reserves as set forth in paragraphs 30-34 of Statement of Financial Accounting...

  18. Tucumcari, NM TX 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  19. Santa Fe, NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  20. Gallup, NM AZ 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  1. Albuquerque, NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  2. Raton, NM CO 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  3. Evaluation of GSt 250/350, Project-Oriented Field Study.

    Science.gov (United States)

    Lunneborg, Patricia W.; Mitchell, Sandra K.

    This report evaluates the effectiveness of an experiential field study course at the University of Washington. The course, titled GST 250/350, has different goals from a traditional volunteer program in that the student's education and experience are paramount; the services he provides are secondary. The student's motivation also differs somewhat…

  4. Hobbs, NM TX 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  5. 30 CFR 250.462 - What are the requirements for well-control drills?

    Science.gov (United States)

    2010-07-01

    ... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Other Drilling Requirements § 250.462 What are the requirements for well-control drills? You must conduct a weekly well-control drill with each drilling crew. Your drill must familiarize the crew with...

  6. 30 CFR 250.402 - When and how must I secure a well?

    Science.gov (United States)

    2010-07-01

    ... GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations General Requirements § 250.402 When and how must I secure a well? Whenever you interrupt drilling operations, you must...) Inability to keep the drilling rig on location; or (3) Repair to major drilling or well-control...

  7. 30 CFR 250.469 - What other well records could I be required to submit?

    Science.gov (United States)

    2010-07-01

    ... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Modify and Well Records § 250.469 What other well records could I be required to... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What other well records could I be required...

  8. Muusikamaailm. Maailmaesiettekanne Krimmis. Herderi preemiad 2002. Opera Metz 250. Günter Wand 90 / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2002-01-01

    Krimmis leiab aset Alemdar Karamanovi sümfoonia "Täideläinu" maailma esiettekanne. Johann Gottfried Herderi muusikapreemia sai nimekas rumeenia helilooja Aurel Stroe. Opera Metz Prantsusmaal tähistab oma 250ndat aastapäeva mitmete uuslavastustega. Dirigent Günter Wand tähistab 90ndat juubelit

  9. LCD OF AIR INTAKE MANIFOLDS PHASE 2: FORD F250 AIR INTAKE MANIFOLD

    Science.gov (United States)

    The life cycle design methodology was applied to the design analysis of three alternatives for the lower plehum of the air intake manifold for us with a 5.4L F-250 truck engine: a sand cast aluminum, a lost core molded nylon composite, and a vibration welded nylon composite. The ...

  10. 30 CFR 250.407 - What tests must I conduct to determine reservoir characteristics?

    Science.gov (United States)

    2010-07-01

    ... of oil, gas, sulphur, and water in the formations penetrated by logging, formation sampling, or well... OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations General Requirements § 250.407 What tests must I conduct to...

  11. 30 CFR 250.467 - How long must I keep records?

    Science.gov (United States)

    2010-07-01

    ... 250.467 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A... BOP tests Two years after the completion of drilling operations. (c) Completion of a well or of...

  12. 20 CFR 411.250 - How will SSA evaluate a PM?

    Science.gov (United States)

    2010-04-01

    ...) Business relations; and (5) Customer satisfaction. (b) Our Project Officer will perform the evaluation. The PM will have an opportunity to comment on the evaluation, and then the Contracting Officer will... Evaluation of Program Manager Performance § 411.250 How will SSA evaluate a PM? (a) We will...

  13. Aztec, NM CO 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  14. El Paso, TX NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  15. Socorro, NM 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  16. 30 CFR 250.223 - What mitigation measures information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What mitigation measures information must... INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Plans and Information Contents of Exploration Plans (ep) § 250.223 What mitigation measures information must accompany the EP?...

  17. 30 CFR 250.254 - What mitigation measures information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What mitigation measures information must... Information Contents of Development and Production Plans (dpp) and Development Operations Coordination Documents (docd) § 250.254 What mitigation measures information must accompany the DPP or DOCD? (a) If...

  18. 30 CFR 250.215 - What hydrogen sulfide (H2S) information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... methodologies outlined in 40 CFR part 68. ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What hydrogen sulfide (H2S) information must... Contents of Exploration Plans (ep) § 250.215 What hydrogen sulfide (H2S) information must accompany the...

  19. 17 CFR 250.23 - Procedure applicable to certain applications and declarations.

    Science.gov (United States)

    2010-04-01

    ... OF 1935 Forms, Procedure and Accounts § 250.23 Procedure applicable to certain applications and... Uniform System of Accounts for Public Utility Holding Companies. (b) Designation of filings as... a hearing be held, stating his reasons therefor and the nature of his interest....

  20. 17 CFR 250.26 - Financial statement and recordkeeping requirements for registered holding companies and...

    Science.gov (United States)

    2010-04-01

    ... accounts, books, or other records, except pursuant to 17 CFR part 257. (e) This rule shall not modify or... chart of accounts by the commission which promulgated it. The amendment shall describe the nature..., PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 Forms, Procedure and Accounts § 250.26 Financial statement...

  1. 40 CFR 147.250 - State-administered program-Class II wells.

    Science.gov (United States)

    2010-07-01

    ... California § 147.250 State-administered program—Class II wells. The UIC program for Class II wells in the State of California, except those on Indian lands, is the program administered by the California... reference and made a part of the applicable UIC program under the SDWA for the State of California....

  2. 21 CFR 250.100 - Amyl nitrite inhalant as a prescription drug for human use.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Amyl nitrite inhalant as a prescription drug for... Prescription Status of Specific Drugs § 250.100 Amyl nitrite inhalant as a prescription drug for human use. (a) Amyl nitrite inhalant has been available over-the-counter for emergency use by the patient in...

  3. Potentiality evaluation of the MAT 250 UF mass spectrometer for general analysis

    International Nuclear Information System (INIS)

    This work presents a study on the potentiality of the MAT 250 UF mass spectrometer. It was formerly used only, for uranium isotopic analysis. It will be used, flow now on, also for the analysis of other gases such as deuterium, helium and hydrogen, as well. (A.C.A.S.)

  4. 30 CFR 250.114 - How must I install and operate electrical equipment?

    Science.gov (United States)

    2010-07-01

    .... (a) You must classify all areas according to API RP 500, Recommended Practice for Classification of... Division 2, or API RP 505, Recommended Practice for Classification of Locations for Electrical... (incorporated by reference as specified in § 250.198), or API RP 14FZ, Recommended Practice for Design...

  5. 30 CFR 250.113 - What procedures must I follow when welding?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What procedures must I follow when welding? 250....113 What procedures must I follow when welding? (a) Before you weld, you must move any equipment containing hydrocarbons or other flammable substances at least 35 feet horizontally from the welding...

  6. 30 CFR 250.111 - Who oversees operations under my welding plan?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Who oversees operations under my welding plan... § 250.111 Who oversees operations under my welding plan? A welding supervisor or a designated person in charge must be thoroughly familiar with your welding plan. This person must ensure that each welder...

  7. 30 CFR 250.110 - What must I include in my welding plan?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I include in my welding plan? 250.110... must I include in my welding plan? You must include all of the following in the Welding Plan that you... qualified personnel weld; (c) Practices and procedures for safe welding that address: (1) Welding...

  8. 30 CFR 250.1408 - When will I be notified of the Reviewing Officer's decision?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When will I be notified of the Reviewing... Continental Shelf (OCS) Civil Penalties § 250.1408 When will I be notified of the Reviewing Officer's decision... Reviewing Officer will review the case file, including all information you submitted, and send you...

  9. 50 CFR 216.250 - Specified activity and specified geographical region.

    Science.gov (United States)

    2010-10-01

    ... OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE... Weapon Missions in the Gulf of Mexico § 216.250 Specified activity and specified geographical region. (a... within the Eglin Air Force Base Gulf Test and Training Range within the northern Gulf of Mexico....

  10. Comparison of differences between MODIS 250 m and 1 km cloud masks

    Science.gov (United States)

    Kotarba, Andrzej Z.

    2016-11-01

    The spatial resolution of remote sensing instruments installed onboard satellites is one of the key factors for accurate estimations of cloud amount. In general terms, the larger the instantaneous field of view (IFOV), the greater the overestimation of cloud amount - assuming that data are collected with exactly the same methodology, and processed with exactly the same algorithms. While most meteorological imagers collect data at a spatial resolution of 1 km, the Moderate Resolution Imaging Spectroradiometer (MODIS) offers cloud amount estimates at both 1 km (the standard product) and 250 m (additional, high-resolution products). However, these datasets are produced using different methodological approaches, which impacts the quality and reliability of the product. This study compared 250 m data with 1 km data over elevated terrain with complex orography. Results showed significant discrepancies between the datasets, with 250 m data reporting mean seasonal (June-August) cloud amount 15.8% lower, than 1 km dataset. This was not related to the presence of snow, or to the increased spatial resolution of the cloud mask. On the other hand, both 1 km and 250 m data described similar spatial variability in mean monthly cloud amount (correlation coefficients of 0.85-0.98, p < 0.01).

  11. 30 CFR 250.901 - What industry standards must your platform meet?

    Science.gov (United States)

    2010-07-01

    ..., Building Code Requirements for Reinforced Concrete (ACI 318-95) and Commentary (ACI 318R-95) (incorporated..., Specification for Structural Steel Buildings, (incorporated by reference as specified in § 250.198); (4...); (22) AWS D3.6M, Specification for Underwater Welding, (incorporated by reference as specified in §...

  12. 30 CFR 250.1165 - What must I do for enhanced recovery operations?

    Science.gov (United States)

    2010-07-01

    ... Supervisor and receive approval for pressure maintenance, secondary or tertiary recovery, cycling, and... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I do for enhanced recovery operations... Requirements Other Requirements § 250.1165 What must I do for enhanced recovery operations? (a) You...

  13. 30 CFR 250.518 - What are the requirements for casing pressure management?

    Science.gov (United States)

    2010-07-01

    ... Operations Casing Pressure Management § 250.518 What are the requirements for casing pressure management? Once you install your wellhead, you must meet the casing pressure management requirements of API RP 90... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the requirements for casing...

  14. 30 CFR 250.1717 - After I permanently plug a well, what information must I submit?

    Science.gov (United States)

    2010-07-01

    ... Decommissioning Activities Permanently Plugging Wells § 250.1717 After I permanently plug a well, what information must I submit? Within 30 days after you permanently plug a well, you must submit form MMS-124... 30 Mineral Resources 2 2010-07-01 2010-07-01 false After I permanently plug a well,...

  15. 30 CFR 250.1753 - After I decommission a pipeline, what information must I submit?

    Science.gov (United States)

    2010-07-01

    ... Decommissioning Activities Pipeline Decommissioning § 250.1753 After I decommission a pipeline, what information must I submit? Within 30 days after you decommission a pipeline, you must submit a written report to... 30 Mineral Resources 2 2010-07-01 2010-07-01 false After I decommission a pipeline,...

  16. Comparing the Effect of Different Bleaching Regims of Carbamide Peroxide on Microhardness of Z250 Composite

    Directory of Open Access Journals (Sweden)

    B Esmaeili

    2015-11-01

    Full Text Available Introduction: Bleaching products with oxidizing mechanism can exert side effects on the restorative materials existing in the oral cavity. Since bleaching agents are applied in different concentrations, the present study aimed to compare the effect of different bleaching regims of carbamide peroxide on microhardness of Z250 microhybride composite. Methods: In this in vitro study , 32 specimens of micro hybride composite (Z250 were made which were randomly divided into 4 subgroups (n=8: G1: bleached with10% carbamide peroxide 4 hours a day for 2 weeks G2: bleached with 16%carbamide peroxide 3 hours a day for 2 weeks G3: bleached with 22%carbamide peroxide 1hour a day for 2 weeks G4: the control subgroup stored in distilled water at 37◦c for 2 weeks. Microhardness of specimens was measured before and after bleaching using Vickers hardness testing machine. Moreover, the study data were analyzed statistically applying Anova and t-test (&alpha= 0.05. Results: This study findings revealed that using bleaching agent significantly decreased the  microhardness of composite resin in the bleaching groups compared to the control group, though the concentration of carbamide peroxide produced no significant effect on the microhardness value. (p>0.13 Conclusion: Bleaching therapy can cause a reduction in microhardness of Z250 composite and different concentrations of carbamide peroxide can reduce microhardness of Z250 to the same value.

  17. Analysis of wind power ancillary services characteristics with German 250-MW wind data

    Energy Technology Data Exchange (ETDEWEB)

    Ernst, B.

    1999-12-09

    With the increasing availability of wind power worldwide, power fluctuations have become a concern for some utilities. Under electric industry restructuring in the US, the impact of these fluctuations will be evaluated by examining provisions and costs of ancillary services for wind power. This paper analyzes wind power in the context of ancillary services, using data from a German 250 Megawatt Wind project.

  18. Programmable Ultrasonic Sensing System for Targeted Spraying in Orchards

    OpenAIRE

    Marko Hočevar; Andrej Štrancar; Miran Lakota; Viktor Jejčič; Mario Lešnik; Peter Berk; Denis Stajnko; Jurij Rakun

    2012-01-01

    This research demonstrates the basic elements of a prototype automated orchard sprayer which delivers pesticide spray selectively with respect to the characteristics of the targets. The density of an apple tree canopy was detected by PROWAVE 400EP250 ultrasound sensors controlled by a Cypress PSOC CY8C29466 microcontroller. The ultrasound signal was processed with an embedded computer built around a LPC1343 microcontroller and fed in real time to electro-magnetic valves which open/close spray...

  19. Electrically charged targets

    Science.gov (United States)

    Goodman, Ronald K.; Hunt, Angus L.

    1984-01-01

    Electrically chargeable laser targets and method for forming such charged targets in order to improve their guidance along a predetermined desired trajectory. This is accomplished by the incorporation of a small amount of an additive to the target material which will increase the electrical conductivity thereof, and thereby enhance the charge placed upon the target material for guidance thereof by electrostatic or magnetic steering mechanisms, without adversely affecting the target when illuminated by laser energy.

  20. Revamp of cable reel on 250 t converter ladle car%250 t转炉钢包车电缆卷筒改造

    Institute of Scientific and Technical Information of China (English)

    叶国英

    2014-01-01

    In view of the problems of burning the cable and the cable reel not running in No.3 Branch of General Steel-making Plant of WISCO,which led to the maintenance cost rising and affected the production,the drive way of cable reel and the cable sizing were optimized in 250 t converter ladle car.After that,the maintenance cost is de-creased deeply,and only 2 cables are needed by a ladle car every year,which ensure the normal production.%针对武钢炼钢总厂三分厂经常出现电缆烧损、电缆卷筒不转故障导致维修成本上升且影响生产的问题,对250 t转炉钢包车电缆卷筒的传动方式、电缆选型进行了改造。改造后,每台钢包车每年只需更换2根电缆,大大降低了维护成本,保证了生产的正常运行。

  1. N250r and N400 ERP correlates of immediate famous face repetition are independent of perceptual load.

    Science.gov (United States)

    Neumann, Markus F; Schweinberger, Stefan R

    2008-11-01

    It is a matter of considerable debate whether attention to initial stimulus presentations is required for repetition-related neural modulations to occur. Recently, it has been assumed that faces are particularly hard to ignore, and can capture attention in a reflexive manner. In line with this idea, electrophysiological evidence for long-term repetition effects of unattended famous faces has been reported. The present study investigated influences of attention to prime faces on short-term repetition effects in event-related potentials (ERPs). We manipulated attention to short (200 ms) prime presentations (S1) of task-irrelevant famous faces according to Lavie's Perceptual Load Theory. Participants attended to letter strings superimposed on face images, and identified target letters "X" vs. "N" embedded in strings of either 6 different (high load) or 6 identical (low load) letters. Letter identification was followed by probe presentations (S2), which were either repetitions of S1 faces, new famous faces, or infrequent butterflies, to which participants responded. Our ERP data revealed repetition effects in terms of an N250r at occipito-temporal regions, suggesting priming of face identification processes, and in terms of an N400 at the vertex, suggesting semantic priming. Crucially, the magnitude of these effects was unaffected by perceptual load at S1 presentation. This indicates that task-irrelevant face processing is remarkably preserved even in a demanding letter detection task, supporting recent notions of face-specific attentional resources. PMID:18793621

  2. A gas/liquid chromatographic-mass spectrometric method for the rapid screening of 250 pesticides in aqueous matrices

    Energy Technology Data Exchange (ETDEWEB)

    Chandramouli, B.; Harvan, D.; Brittain, S.; Hass, R. [Eno River Labs, LLC. Durham, NC (United States)

    2004-09-15

    Pesticide residues in food present a potentially serious and significant cause for concern. Many pesticides have been associated with significant health effects to the nervous and endocrine systems and some have been deemed carcinogenic. There are many well-established techniques for pesticide analysis. However, commercial pesticide methods have traditionally only been available for specific pesticide families, such as chlorinated pesticides or herbicides, and at detection limits ranging from 0.05 ppb to 1 ppm in aqueous matrices. Techniques that can quickly screen for the presence/absence of pesticide residues in food matrices are critical in ensuring the safety of food and water. This paper outlines a combined Gas Chromatographic-High Resolution Mass Spectrometric (GC-HRMS) and Liquid Chromatographic Tandem Mass Spectrometric (LC-MS/MS) screening assay for 250 pesticides that was developed for use in water, and soda samples at screening levels ranging from 0.1-5 ppb. The pesticides selected have been identified by the European Union as being of concern and the target of possible legislation. The list encompasses a variety of pesticide classes and compound groupings.

  3. Flayer target acceleration and energy transfer at its collision with massive targets

    International Nuclear Information System (INIS)

    Investigations of efficiency of macroparticle acceleration and crater creation processes for the two wavelengths of the PALS (Prague Asterix Laser System) facility laser beam: λ1=1.315 μm and λ3=0.438 μm, and two types of targets made of Al: single massive target and double target consisting of a foil (thickness of 6 and 11 μm) placed before the massive target at the distance of 200-500 μm are presented. Targets were irradiated by the iodine laser beam: EL=120-240 J, the focal spot diameter of 250 μm, and the pulse duration of 0.4 ns. Velocities of the accelerated macroparticles as well as electron density distributions of plasma stream were determined by means of a 3-frame interferometry. Shape and volume of craters were obtained employing crater replica technology and microscopy measurement. Experimental results were analyzed and interpreted by means of two-dimensional theoretical and numerical simulations. Energy transfer as well as two- dimensional shock wave generation and crater formation at the collision of laser-driven macroparticle with massive target have been described. The values of laser energy absorption coefficient, ablation loading efficiency and efficiency of energy transfer at the laser-driven macroparticle impact have been obtained at the different wavelength of laser radiation by crater volume measurement data. (author)

  4. Fast ignitor target studies for HiPER

    Energy Technology Data Exchange (ETDEWEB)

    Atzeni, S; Bellei, C; Schiavi, A [Dipartimento di Energetica, Universita di Roma ' La Sapienza' and CNISM (Italy); Davies, J R; Silva, L; Sorasio, G [Instituto Superior Tecnico, Lisbon (Portugal); Evans, R G [The Blackett Laboratory, Imperial College, Prince Consort Road, London (United Kingdom); Honrubia, J J [GIFI, Universidad Politecnica, Madrid (Spain); Nicolai, P; Ribeyre, X; Schurtz, G; Olazabal, M [CELIA, Universite Bordeaux 1, Talence (France); Badziak, J [IPPLM, Euratom Association, Warsaw (Poland); Meyer-ter-Vehn, J [Max-Planck-Institut fuer Quantenoptik, Garching (Germany)], E-mail: javier.honrubia@upm.es

    2008-05-15

    The HiPER facility has been proposed recently to demonstrate fast ignition of laser driven inertial fusion targets. According to the present design, HiPER will have a 3{omega}, multi-beam, multi-ns-pulse of about 250 kJ and a 2{omega} or 3{omega} ignition beam delivering 70 kJ in about 15 ps. We present here studies on laser-driven fast-ignitor targets driven by 100-300 kJ compression pulses, followed by 70-100 kJ ignition pulses.

  5. KP-250螺旋挤压式固液分离机的设计及试验%Design and Experiment of KP-250 Screw Separator

    Institute of Scientific and Technical Information of China (English)

    申江涛; 吴德胜; 赵明杰; 蒋建群; 马学良; 郭楠

    2014-01-01

    Manure pollution problems of livestock and poultry farms has raised concern in the whole society , therefore , the government are paying more and more attention to environment protection of livestock and poultry farms .How to solve the manure pollution problem in condition of not affecting the production efficiency or even can improve the economic benefit of the farms has become a top priority .Screw separator is a new kind of separation device , has the function of gravity filtration、squeezing filtration and high pressure squeeze .It can successfully crack this problem .This article illus-trated the overall structure and working principle of KP-250 screw separator ,analyzed the key problems in the process of designing screw separator .It also studied and designed the general structure ,screw squeezing device ,screen mesh ,the gap between the screw and the screen ,discharging device and drive system .Test results indicated that :KP-250 screw separator was designed reasonable ,safe and reliable .It was suitable for solving the manure pollution problems of farms ( cattle and pig farms ) ,and so as to promote the development of environmental protection career of modern livestock and poultry farm .%养殖场畜禽粪便污染问题已经蔓延成为全社会关注的问题,国家对养殖场的环保越来越重视。如何在不影响养殖场生产效益抑或能提高养殖场经济效益的前提下解决粪污处理的难题,成为了当务之急。螺旋挤压式固液分离机是将重力过滤、挤压过滤以及高压压榨融为一体的新型分离装置,可成功破解这一难题。为此,阐述了KP-250螺旋挤压式固液分离的总体结构和工作原理,分析了固液分离机设计所要解决的关键问题。对总体结构、螺旋挤压结构、筛网、螺旋和筛网的间隙、出料装置及驱动系统进行了研究和设计。试验结果表明:KP-250固液分离机设计合理,安全可靠,适用于养殖场(养

  6. A 14-bit 250-MS/s current-steering CMOS digital-to-analog converter

    Institute of Scientific and Technical Information of China (English)

    Li Xueqing; Fan Hua; Wei Qi; Xu Zhen; Liu Jianan; Yang Huazhong

    2013-01-01

    A 14-bit 250-MS/s current-steering digital-to-analog converter (DAC) was fabricated in a 0.13 μm CMOS process.In conventional high-speed current-steering DACs,the spurious-free dynamic range (SFDR) is limited by nonlinear distortions in the code-dependent switching glitches.In this paper,the bottleneck is mitigated by the time-relaxed interleaving digital-random-return-to-zero (TRI-DRRZ).Under 250-MS/s sampling rate,the measured SFDR is 86.2 dB at 5.5-MHz signal frequency and 77.8 dB up to 122 MHz.The DAC occupies an active area of 1.58 mm2 and consumes 226 mW from a mixed power supply of 1.2/2.5 V.

  7. Debye relaxation and 250 K anomaly in glass forming monohydroxy alcohols

    CERN Document Server

    Bauer, S; Gainaru, C; Lunkenheimer, P; Hiller, W; Loidl, A; Böhmer, R

    2013-01-01

    A previous dielectric, near-infrared (NIR), and nuclear magnetic resonance study on the hydrogen-bonded liquid 2-ethyl-1-hexanol [C. Gainaru et al., Phys. Rev. Lett. 107, 118304 (2011)] revealed anomalous behavior in various static quantities near 250 K. To check whether corresponding observations can be made for other monohydroxy alcohols as well, these experimental methods were applied to such substances with 5, 6, 7, 8, and 10 carbon atoms in their molecular backbone. All studied liquids exhibit a change of behavior near 250 K which is tentatively ascribed to effects of hydrogen bond cooperativity. By analyzing the NIR band intensities, a linear cluster size is derived that agrees with estimates from dielectric spectroscopy. All studied alcohols, except 4-methyl-3-heptanol, display a dominant Debye-like peak. Furthermore, neat 2-ethyl-1-butanol exhibits a well resolved structural relaxation in its dielectric loss spectrum which so far has only been observed for diluted monohydroxy alcohols.

  8. A low-power 10-bit 250-KSPS cyclic ADC with offset and mismatch correction*

    Institute of Scientific and Technical Information of China (English)

    Zhao Hongliang; Zhao Yiqiang; Geng Junfeng; Li Peng; Zhang Zhisheng

    2011-01-01

    A low power 10-bit 250-k sample per second (KSPS) cyclic analog to digital converter (ADC) is presented. The ADC's offset errors are successfully cancelled out through the proper choice of a capacitor switching sequence. The improved redundant signed digit algorithm used in the ADC can tolerate high levels of the comparator's offset errors and switched capacitor mismatch errors. With this structure, it has the advantages of simple circuit configuration, small chip area and low power dissipation. The cyclic ADC manufactured with the Chartered 0.35 μm 2P4M process shows a 58.5 dB signal to noise and distortion ratio and a 9.4 bit effective number of bits at a 250 KSPS sample rate. It dissipates 0.72 mW with a 3.3 V power supply and occupies dimensions of 0.42 × 0.68 mm2.

  9. New evidence for 250 Ma age of halotolerant bacterium from a Permian salt crystal

    Science.gov (United States)

    Satterfield, Cindy L.; Lowenstein, Tim K.; Vreeland, Russell H.; Rosenzweig, William D.; Powers, Dennis W.

    2005-04-01

    The purported oldest living organism, the spore-forming bacterium Virgibacillus sp. Permian strain 2 9-3, was recently cultured from a brine inclusion in halite of the 250 Ma Permian Salado Formation. However, the antiquity of Virgibacillus sp. 2 9-3 has been challenged; it has been argued that the halite crystal and the fluid inclusion from which the bacterial spores were extracted may be younger than the Permian Salado salts. Here we report that brine inclusions from the same layer of salt that housed Virgibacillus sp. 2 9-3 are composed of evaporated Late Permian seawater that was trapped in halite cement crystals precipitated syndepositionally from shallow groundwater brines at temperatures of 17 37 °C. These results support the 250 Ma age of the fluid inclusions, and by inference, the long-term survivability of microorganisms such as Virgibacillus sp. 2 9-3.

  10. Dispersive spherical optical model of neutron scattering from Al27 up to 250 MeV

    CERN Document Server

    Molina, A; Quesada, J M; Lozano, M

    2002-01-01

    A spherical optical model potential (OMP) containing a dispersive term is used to fit the available experimental database of angular distribution and total cross section data for n + Al27 covering the energy range 0.1- 250 MeV using relativistic kinematics and a relativistic extension of the Schroedinger equation. A dispersive OMP with parameters that show a smooth energy dependence and energy independent geometry are determined from fits to the entire data set. A very good overall agreement between experimental data and predictions is achieved up to 150 MeV. Inclusion of nonlocality effects in the absorptive volume potential allows to achieve an excellent agreement up to 250 MeV.

  11. A 250 GHz Gyrotron with a 3 GHz Tuning Bandwidth for Dynamic Nuclear Polarization

    OpenAIRE

    Barnes, Alexander B.; Nanni, Emilio A.; Herzfeld, Judith; Griffin, Robert G.; Temkin, Richard J.

    2012-01-01

    We describe the design and implementation of a novel tunable 250 GHz gyrotron oscillator with >10 W output power over most of a 3 GHz band and >35 W peak power. The tuning bandwidth and power are sufficient to generate a >1 MHz nutation frequency across the entire nitroxide EPR lineshape for cross effect DNP, as well as to excite solid effect transitions utilizing other radicals, without the need for sweeping the NMR magnetic field. Substantially improved tunability is achieved by implementin...

  12. On the economic dimensions of CSR: Exploring Fortune Global 250 reports

    OpenAIRE

    Fortanier, F.N.; Kolk, A.

    2007-01-01

    The macro-level debate on the economic impact of multinational enterprises (MNEs) is still unsettled. This article explores micro-level evidence by examining what Fortune Global 250 firms themselves report about their economic impact. Such reporting embodies corporate attempts to account for their economic implications, in addition to the environmental and social aspects of their activities that have traditionally received more attention in the context of corporate responsibility. Firms' repo...

  13. Clinical analysis of 250 cases of ultrasound-guided percutaneous fine needle aspiration of pancreatic mass

    Institute of Scientific and Technical Information of China (English)

    王仕迎

    2014-01-01

    Objective To assess the accuracy and safety of cytopathological diagnosis of ultrasound guided fine needle aspirated(US-FNA)pancreatic masses.Methods From January 2008 to February 2013,250 pancreatic mass cases underwent US-FNA and with cytopathological diagnosis were retrospectively analyzed.The sensitivity,specificity,positive predictive value,negative predictive value and accuracy were calculated.The stratified analysis of

  14. Impulsore Chresto. Opposition to Christianity in the Roman Empire c. 50-250 AD

    DEFF Research Database (Denmark)

    Engberg, Jakob

    Impulsore Chresto reassesses opposition to Christianity AD 50-250. The Roman authorities' persecutions have caught the attention of both the public, intrigued by martyrs, and scholars, arguing that executions were relatively rare. The latter is not challenged, but the executions are placed in con......, spectators or local officials were crucial. There were as many reasons for opposition as opponents, but some motives reappear in clusters: Christians were perceived as superstitious and ungodly, as endangering peace with the gods and social order....

  15. Adsorption of Sulfamethazine from Environmentally Relevant Aqueous Matrices onto Hypercrosslinked Adsorbent MN250.

    Science.gov (United States)

    Grimmett, Maria E

    2015-07-01

    Four hundred tons of sulfamethazine are fed to livestock annually in North America for disease prevention and growth promotion, but the majority is excreted unmetabolized into the environment. Due to its slow degradation and high mobility, sulfamethazine contaminates groundwater and causes aquatic ecosystem damage. Sulfamethazine remediation methods are not universally effective, necessitating newer techniques. Hypercrosslinked polystyrene adsorbents show promise because of high surface areas, durability, and regenerable properties. Using batch techniques, sulfamethazine adsorption onto Purolite MN250 was evaluated in the presence of dissolved humic acid and under variable pH and ionic strength. The adsorption capacity () of MN250 for sulfamethazine with humic acid was 109.3 mg g. In simulated groundwater, at pH 5 was 51 to 62% higher than at pH 9. The maximum at pH 7 (144.0 mg g) exceeded pH 5 performance (128.3 mg g). In 0.005 M KCl, was 181.0 mg g, which decreased by 34% in 0.05 M KCl. In 0.5 M, KCl, (153.4 mg g) increased 26% over 0.05 M KCl. For all matrices, equilibration was attained between 120 and 168 h, best fit by Ho's pseudo-second-order model. Overall, is pH dependent because the sulfamethazine speciation and the zeta potential of MN250 vary as a function of pH. Increasing ionic strength initially decreases by altering the activity coefficient of sulfamethazine and by altering the properties of the electrical double layer, while salting-out becomes prominent at seawater concentration. MN250's high sulfamethazine capacity in environmentally relevant aqueous matrices highlights its potential for groundwater remediation. PMID:26437099

  16. Women in the Boardrooms of FTSE 250 Companies and Their Impact on Firm Performance

    OpenAIRE

    Kingham, Ashley

    2015-01-01

    The purpose of this study was to examine whether there is a relationship between the amount of female directors on the boards of FTSE 250 companies and the observed companies’ performance. Previous researchers have had mixed results and differing opinions on the effects of this relationship, with papers finding positive and negative relationships, there are also several notable papers finding no relationship at all between these two factors. This study was carried out using data from 201...

  17. TARGET COSTING FUNCTIONS

    OpenAIRE

    Dimi OFILEANU

    2015-01-01

    This article aims to highlight the concept of Target Costing. Based on the characteristics of Target Costing, identified in specialized literature, the article presents its main advantages and disadvantages. Also, a comparison is being made between Target Cost and Traditional Cost (in its traditional form, the cost represents an independent variable on the basis of which the sell price is established; and in the Target Cost form the cost represents a dependent variable which is determined on ...

  18. Multilayer polymer microspot targets

    International Nuclear Information System (INIS)

    Last year the authors reported on the development of a seeded microspot x-ray diagnostic target. This target consisted of a 300-μm-diam, 2-μm-thick disk of silicon or sulfur-seeded hydrocarbon polymer nested tightly in a hole in a 2-μm-thick film of pure hydrocarbon polymer. This year they extended our work on the microspot target, fully encapsulating the microspot in what they call the multilayer polymer microspot target

  19. The Targeting of Advertising

    OpenAIRE

    Ganesh Iyer; David Soberman; J. Miguel Villas-Boas

    2005-01-01

    An important question that firms face in advertising is developing effective media strategy. Major improvements in the quality of consumer information and the growth of targeted media vehicles allow firms to precisely target advertising to consumer segments within a market. This paper examines advertising strategy when competing firms can target advertising to different groups of consumers within a market. With targeted advertising, we find that firms advertise more to consumers who have a st...

  20. Target Price Accuracy

    OpenAIRE

    Alexander G. Kerl

    2011-01-01

    This study analyzes the accuracy of forecasted target prices within analysts’ reports. We compute a measure for target price forecast accuracy that evaluates the ability of analysts to exactly forecast the ex-ante (unknown) 12-month stock price. Furthermore, we determine factors that explain this accuracy. Target price accuracy is negatively related to analyst-specific optimism and stock-specific risk (measured by volatility and price-to-book ratio). However, target price accuracy is positive...

  1. 12 CFR 250.401 - Director serving member bank and closed-end investment company being organized.

    Science.gov (United States)

    2010-01-01

    ... that a closed-end company which was in process of organization and was actively engaged in issuing and... investment company being organized. 250.401 Section 250.401 Banks and Banking FEDERAL RESERVE SYSTEM... company being organized. (a) The Board has previously expressed the opinion (§ 218.101) that section 32...

  2. 12 CFR 250.412 - Interlocking relationships between member bank and insurance company-mutual fund complex.

    Science.gov (United States)

    2010-01-01

    ... mutual fund shares and life insurance policies that would provide increased competitive strength in a... Fund, Inc. (“Fund”), the mutual fund, was closely related to X Life Insurance Company (“Insurance... and insurance company-mutual fund complex. 250.412 Section 250.412 Banks and Banking FEDERAL...

  3. 75 FR 62919 - Notice of Final Federal Agency Actions on the Route 250 Bypass Interchange at McIntire Road...

    Science.gov (United States)

    2010-10-13

    ... of Route 250 Bypass and McIntire Road. The project would reduce traffic congestion and improve... at McIntire Road Project in Virginia AGENCY: Federal Highway Administration (FHWA), DOT. ACTION... the Route 250 Bypass Interchange at McIntire Road project in the City of Charlottesville,...

  4. Geluidimmissie van Thalys en Ansaldo V250 treinen op het HSL spoor bij twee woningen in Kaag en Braassem

    NARCIS (Netherlands)

    Hof, J. van 't; Staats, F.; Graafland, F.; Prevo, R.

    2014-01-01

    TNO heeft in opdracht van ProRail de geluidimmissieniveaus gemeten van de Ansaldo V250 en de Thalys hogesnelheidstreinen die op het spoor van de HSL-Zuid met hoge snelheid rijden, bij twee woningen in de gemeente Kaag en Braassem. Tijdens dit onderzoek rijden er treinen van het type Ansaldo V250, Th

  5. 12 CFR 250.141 - Member bank purchase of stock of “operations subsidiaries.”

    Science.gov (United States)

    2010-01-01

    ... other words, a wholly owned subsidiary corporation engaged in activities that the bank itself may... the bank either directly, or indirectly through a wholly-owned subsidiary corporation. (j) This... subsidiaries.â 250.141 Section 250.141 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF...

  6. 30 CFR 250.150 - How do I name facilities and wells in the Gulf of Mexico Region?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I name facilities and wells in the Gulf of Mexico Region? 250.150 Section 250.150 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT... and wells in the Gulf of Mexico Region? (a) Assign each facility a letter designation except for...

  7. 30 CFR 250.248 - What solid and liquid wastes and discharges information and cooling water intake information must...

    Science.gov (United States)

    2010-07-01

    ... information and cooling water intake information must accompany the DPP or DOCD? 250.248 Section 250.248... and discharges information and cooling water intake information must accompany the DPP or DOCD? The following solid and liquid wastes and discharges information and cooling water intake information...

  8. 30 CFR 250.217 - What solid and liquid wastes and discharges information and cooling water intake information must...

    Science.gov (United States)

    2010-07-01

    ... information and cooling water intake information must accompany the EP? 250.217 Section 250.217 Mineral... What solid and liquid wastes and discharges information and cooling water intake information must accompany the EP? The following solid and liquid wastes and discharges information and cooling water...

  9. Silicon epitaxy on H-terminated Si (100) surfaces at 250 °C

    Science.gov (United States)

    Deng, Xiao; Namboodiri, Pradeep; Li, Kai; Wang, Xiqiao; Stan, Gheorghe; Myers, Alline F.; Cheng, Xinbin; Li, Tongbao; Silver, Richard M.

    2016-08-01

    Low temperature Si epitaxy has become increasingly important due to its critical role in the encapsulation and performance of buried nanoscale dopant devices. We demonstrate epitaxial growth up to nominally 25 nm, at 250 °C, with analysis at successive growth steps using STM and cross section TEM to reveal the nature and quality of the epitaxial growth. STM images indicate that growth morphology of both Si on Si and Si on H-terminated Si (H: Si) is epitaxial in nature at temperatures as low as 250 °C. For Si on Si growth at 250 °C, we show that the Si epitaxial growth front maintains a constant morphology after reaching a specific thickness threshold. Although the in-plane mobility of silicon is affected on the H: Si surface due to the presence of H atoms during initial sub-monolayer growth, STM images reveal long range order and demonstrate that growth proceeds by epitaxial island growth albeit with noticeable surface roughening.

  10. Shielding calculations for a 250 MeV hospital-based proton accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Agosteo, S. [Politecnico di Milano (Italy). Ist. di Ingegneria Nucleare; Arduini, G. [Fondazione Italiana Ricerca sul Cancro, via Corridoni 7, 20122 Milano (Italy); Bodei, G. [Politecnico di Milano (Italy). Ist. di Ingegneria Nucleare; Monti, S. [ENEA, ERG-FISS-FIRE, via Martiri di Monte Sole 4, 40129 Bologna (Italy); Padoani, F. [ENEA, ERG-FISS-FIRE, via Martiri di Monte Sole 4, 40129 Bologna (Italy); Silari, M. [Consiglio Nazionale delle Ricerche, Istituto Tecnologie Biomediche Avanzate, via Ampere 56, I-20131, Milano (Italy); Tinti, R. [ENEA, ERG-FISS-FIRE, via Martiri di Monte Sole 4, 40129 Bologna (Italy); Tromba, G. [Sincrotrone (``ELETTRA``) Trieste, Padriciano 99, 34012 Trieste (Italy)

    1996-05-21

    The accelerator shields (250 MeV protons, 400 MeV/u {sup 16}O{sup 8+} ions) and treatment rooms of the Hadrontherapy Centre, a hospital-based facility under design in Italy, were determined by means of Monte Carlo calculations. The LCS and FLUKA codes were employed, together with analytical estimates carried out by making use of empirical formulas from the literature, and the results compared. In the case of 250 MeV protons a 250 cm thick concrete wall ensures an annual dose equivalent lower than 2 mSv in the environments adjacent to the accelerator room. The best ceiling thickness was found to be 200 cm for a unitary occupancy factor. The photon dose equivalent beyond the concrete shield was also estimated using the LCS code. In the case of ions the shield thickness was calculated using empirical formulas from the literature; the concrete thicknesses calculated for protons should ensure the required dose equivalent when some local shields are added. Monte Carlo calculations of the treatment room shielding were also carried out using the FLUKA code. (orig.).

  11. A 250 GHz Survey of High Redshift QSOs from the Sloan Digital Sky Survey

    CERN Document Server

    Carilli, C L; Rupen, M P; Fan, X; Strauss, M A; Menten, K M; Kreysa, E; Schneider, D P; Bertarini, A; Yun, M S; Zylka, R; Fan, Xiaohui; Strauss, Michael A.; Schneider, Donald P.

    2001-01-01

    We present observations at 250 GHz (1.2 mm), 43 GHz, and 1.4 GHz of a sample of 41 QSOs at z > 3.7 found in the Sloan Digital Sky Survey. We detect 16 sources with a 250 GHz flux density greater than 1.4 mJy. The combination of centimeter and millimeter wavelength observations indicates that the 250 GHz emission is most likely thermal dust emission. Assuming a dust temperature of 50 K, the implied dust masses for the 16 detected sources are in the range 1.5e8 to 5.9e8 Msun, and the dust emitting regions are likely to be larger than 1 kpc in extent. The radio-through-optical spectral energy distributions for these sources are within the broad range defined by lower redshift, lower optical luminosity QSOs. We consider possible dust heating mechanisms, including UV emission from the active nucleus (AGN) and a starburst concurrent with the AGN, with implied star formation rates between 500 and 2000 Msun/year.

  12. An actionable climate target

    Science.gov (United States)

    Geden, Oliver

    2016-05-01

    The Paris Agreement introduced three mitigation targets. In the future, the main focus should not be on temperature targets such as 2 or 1.5 °C, but on the target with the greatest potential to effectively guide policy: net zero emissions.

  13. High Power Cryogenic Targets

    Energy Technology Data Exchange (ETDEWEB)

    Gregory Smith

    2011-08-01

    The development of high power cryogenic targets for use in parity violating electron scattering has been a crucial ingredient in the success of those experiments. As we chase the precision frontier, the demands and requirements for these targets have grown accordingly. We discuss the state of the art, and describe recent developments and strategies in the design of the next generation of these targets.

  14. p250GAP is a novel player in the Cdh1-APC/Smurf1 pathway of axon growth regulation.

    Directory of Open Access Journals (Sweden)

    Madhuvanthi Kannan

    Full Text Available Axon growth is an essential process during brain development. The E3 ubiquitin ligase Cdh1-APC has emerged as a critical regulator of intrinsic axon growth control. Here, we identified the RhoGAP p250GAP as a novel interactor of the E3 ubiquitin ligase Cdh1-APC and found that p250GAP promotes axon growth downstream of Cdh1-APC. We also report that p250GAP undergoes non-proteolytic ubiquitination and associates with the Cdh1 substrate Smurf1 to synergistically regulate axon growth. Finally, we found that in vivo knockdown of p250GAP in the developing cerebellar cortex results in impaired migration and axonal growth. Taken together, our data indicate that Cdh1-APC together with the RhoA regulators p250GAP and Smurf1 controls axon growth in the mammalian brain.

  15. Targeted cancer therapies

    Institute of Scientific and Technical Information of China (English)

    Li Yan; Neal Rosen; Carlos Arteaga

    2011-01-01

    With unprecedented understanding of molecular events underlying human cancer in this genomic era, a large number of drugs specifically targeting hypothesized oncogenic drivers to which tumors are potentially addicted to have been developed and continue to be developed. These targeted cancer therapies are being actively tested in clinical trials with mixed successes. This editorial provides an overview on successful targeted cancer drugs on the market and those drugs that are in late clinical development stages. Importantly, the article lays out main challenges in developing molecular targeted therapies and potential path forward to overcome these challenges, as well as opportunities for China in this new era of targeted agents. The editorial serves as an introduction to the Targeted Cancer Therapies serias that will review in depth of major pathways and drugs targeting these pathways to be published in the coming issues of the Chinese Journal of Cancer.

  16. Polarized targets and beams

    International Nuclear Information System (INIS)

    First the experimental situation of the single-pion photoproduction and the photodisintegration of the deuteron is briefly discussed. Then a description of the Bonn polarization facilities is given. The point of main effort is put on the polarized target which plays a vital role in the program. A facility for photon induced double polarization experiments at ELSA will be presented in section 4. Properties of a tensor polarized deuteron target are discussed in section 5. The development in the field of polarized targets, especially on new target materials, enables a new generation of polarized target experiments with (polarized) electrons. Some comments on the use of a polarized target in combination with electron beams will be discussed in section 6. Electron deuteron scattering from a tensor polarized deuteron target is considered and compared with other experimental possibilities. (orig./HSI)

  17. Benchmark calculations on residue production within the EURISOL DS project; Part I: thin targets

    CERN Document Server

    David, J.C; Boudard, A; Doré, D; Leray, S; Rapp, B; Ridikas, D; Thiollière, N

    Report on benchmark calculations on residue production in thin targets. Calculations were performed using MCNPX 2.5.0 coupled to a selection of reaction models. The results were compared to nuclide production cross-sections measured in GSI in inverse kinematics

  18. Benchmark calculations on residue production within the EURISOL DS project; Part II: thick targets

    CERN Document Server

    David, J.-C; Boudard, A; Doré, D; Leray, S; Rapp, B; Ridikas, D; Thiollière, N

    Benchmark calculations on residue production using MCNPX 2.5.0. Calculations were compared to mass-distribution data for 5 different elements measured at ISOLDE, and to specific activities of 28 radionuclides in different places along the thick target measured in Dubna.

  19. An Analysis of 250 MDMA Addicts%250例苯丙胺类摇头丸(MDMA)滥用人群分析

    Institute of Scientific and Technical Information of China (English)

    孙毅; 徐本树; 王志强; 金俊; 吕秋霖; 张惠民

    2004-01-01

    目的:了解苯丙胺类物质摇头丸(MDMA)滥用人群人口学特征及其MDMA的精神活性作用.方法:制定统一问卷,对2001年1月-2002年11月在我院住院MDMA滥用者逐一进行登记.结果:总共调查250例摇头丸(MDMA)滥用者.250例MDMA滥用者平均年龄27.25±7.46 a.未婚青年女性141例,占总例数56.6%.文化程度较高,高中以上文化程度165例,占总例数66.04%.滥用方式大多数以啤酒送服,其次是矿泉水、饮料.滥用场所以歌厅和迪厅为主.每周使用2次以上者97例,占38.68%.MDMA的起效时间为25.61±11.06 min,作用持续时间为3.44±1.68 h.滥用后主观感受及行为表现依次为出汗、头晕、口干、心情愉快等.MDMA作用消失后部分滥用者表现为失眠、食欲下降、记忆力减退、厌食、疲乏、睡眠增多、食欲增大等.结论:近年来MDMA滥用者有增多趋势,部分滥用者有向强制性用药的模式趋势发展,应引起人们足够重视.

  20. Improved design of a certaintype GO-Kart of 250 ml discharge%250 ml排量卡丁车的改进设计

    Institute of Scientific and Technical Information of China (English)

    徐振宇; 陈益帅

    2011-01-01

    为解决目前最受市场欢迎的250 ml排量系列卡丁车"减振性能差、在崎岖路面高速行驶稳定性不佳"的问题,将高档轿车上用的双摆臂前轮悬架设计技术整合到这一排量的卡丁车中去,同时改变以往后轮单纯依靠橡胶轮胎减振的情况,后悬架采用整体桥式结构重新设计.在改进设计中开展了卡丁车前、后悬架减振器速度特性试验、等效刚度试验、悬架总体侧倾角刚度试验,提出了将计算机三维设计与试制、试验相结合的改进设计方法.对改进设计前后的减振器阻尼、悬架等效刚度及悬架总体侧倾刚度值的变化进行了评价,并完成了整车试制后的路面测试.试验结果表明,改进后的卡丁车大大提高了崎岖路面行驶的稳定性和平顺性.%In order to solve the problems of poor stability on rugged roads during high - speed driving, as well as poor damping performance of the most popular Kart ( displacement: 250 ml), the following areas were investigated: the double-arm front wheel suspension design of luxury sedans was integrated into the Kart. The past situation of relying solely on the rear wheel damping was changed. And the rear suspension was redesigned with the overall bridge structure. After the tests of the front and rear suspension damper rate, the equivalent stiffness, and the overall roll angle suspension stiffness, the method of combining computer three-dimensional design, trial-manufacture and tests was presented. The absorber's damping, suspension equivalent stiffness and overall roll angle suspension stiffness before and after design improvement were evaluated, and the finished trial - manufactured Kart was tested on the road. The experimental results show that the stability and smoothness of the Kart had been greatly enhanced when it is on rough roads.

  1. A cross section measurement of charm hyperons Ξc+ and Ξc0 in 250 GeV p/K/π-nucleon interactions

    International Nuclear Information System (INIS)

    Fermilab Experiment 769 used a charge-selected, hadron beam of mean energy 250 GeV/c, composed of pions, kaons, and protons, impinging on beryllium, aluminum, copper and tungsten targets. Using a sample of approximately 4000 Ξs- → Λ0π- decays, measurements of the charm baryon forward cross sections times branching ratio π±N → Ξc+X and π±N → Ξc0X are presented. Upper limits on α x BR are also determined for the states Ξc+ → Ξs-π+π+ and Ξc0 → Ξs-π+ produced in (p, π+, π-, K+, K-)-nucleon interactions

  2. A Dependence Study of $\\Xi^{*0}$ and $\\bar{\\Xi}^{*0}$ in 250 GeV/c $\\pi^-$. $K^-$ -nucleon Interactions

    Energy Technology Data Exchange (ETDEWEB)

    Seixas de Rezende, Fabio Antonio; /Rio de Janeiro, CBPF

    2005-04-01

    A direct measurement of the mass number (A) dependence of the production of the hyperon {Xi}*{sup 0} and its opposite {bar {Xi}}*{sup 0} in {pi}{sup -}, K{sup -} beam-nucleon interactions at 250 GeV/c is reported. The data derive from the experiment E769 at Fermilab. The results were obtained for different targets: Be, Al, Cu and W. It was observed the data are found to be well described by the parametrization {sigma}{sub A} = {sigma}{sub 0}A{sup {alpha}}, {alpha} being calculated for different beams. The results obtained are compared with those results of E769 experiment. The results shown here are preliminary.

  3. Targeted tumor radiotherapy

    Directory of Open Access Journals (Sweden)

    Unak Perihan

    2002-01-01

    Full Text Available Targeted tumor radiotherapy is selectively delivery of curative doses of radiation to malignant sites. The aim of the targeted tumor radiotherapy is to use the radionuclides which have high LET particle emissions conjugated to appropriate carrier molecules. The radionuclides are selectively collected by tumor cells, depositing lethal doses to tumor cells while no admission occur to normal cells. In theory, targeted radiotherapy has several advantages over conventional radiotherapy since it allows a high radiation dose to be administered without causing normal tissue toxicity, although there are some limitations in the availability of appropriate targeting agents and in the calculations of administered doses. Therefore, for routine clinical applications more progress is still needed. In this article, the potential use of targeted tumor radiotherapy is briefly reviewed. More general aspects and considerations, such as potential radionuclides, mechanisms of tumor targeting was also outlined.

  4. Commissioning a Rotating Target Wheel Assembly for Heavy Element Studies

    Science.gov (United States)

    Fields, L. D.; Bennett, M. E.; Mayorov, D. A.; Folden, C. M.

    2013-10-01

    The heaviest elements are produced artificially by fusing nuclei of light elements within an accelerator to form heavier nuclei. The most direct method to increase the production rate of nuclei is to increase the beam intensity, necessitating the use of a rotating target to minimize damage to the target by deposited heat. Such a target wheel was constructed for heavy element research at Texas A&M University, Cyclotron Institute, consisting of a wheel with three banana-shaped target cutouts. The target is designed to rotate at 1700 rpm, and a fiber optic cable provides a signal to trigger beam pulsing in order to avoid irradiating the spokes between target segments. Following minor mechanical modifications and construction of a dedicated electrical panel, the rotating target assembly was commissioned for a beam experiment. A 15 MeV/u beam of 20Ne was delivered from the K500 cyclotron and detected by a ruggedized silicon detector. The beam pulsing response time was characterized as a function of the rational frequency of the target wheel. Preliminary analysis suggests that the K500 is capable of pulsing at rates of up to 250 Hz, which is sufficient for planned future experiments. Funded by DOE and NSF-REU Program.

  5. Moving Target Defense

    CERN Document Server

    Jajodia, Sushil; Swarup, Vipin; Wang, Cliff; Wang, X Sean

    2011-01-01

    Moving Target Defense: Creating Asymmetric Uncertainty for Cyber Threats was developed by a group of leading researchers. It describes the fundamental challenges facing the research community and identifies new promising solution paths. Moving Target Defense which is motivated by the asymmetric costs borne by cyber defenders takes an advantage afforded to attackers and reverses it to advantage defenders. Moving Target Defense is enabled by technical trends in recent years, including virtualization and workload migration on commodity systems, widespread and redundant network connectivity, instr

  6. Deuterium High Pressure Target

    CERN Document Server

    Perevozchikov, V; Vinogradov, Yu I; Vikharev, M D; Ganchuk, N S; Golubkov, A N; Grishenchkin, S K; Demin, A M; Demin, D L; Zinov, V G; Kononenko, A A; Lobanov, V N; Malkov, I L; Yukhimchuk, S A

    2001-01-01

    The design of the deuterium high-pressure target is presented. The target having volume of 76 cm^3 serves to provide the experimental research of muon catalyzed fusion reactions in ultra-pure deuterium in the temperature range 80-800 K under pressures of up to 150 MPa. The operation of the main systems of the target is described: generation and purification of deuterium gas, refrigeration, heating, evacuation, automated control system and data collection system.

  7. Deuterium high pressure target

    International Nuclear Information System (INIS)

    The design of the deuterium high-pressure target is presented. The target having volume of 76 cm3 serves to provide the experimental research of muon catalyzed fusion reactions in ultra-pure deuterium in the temperature range 80-800 K under pressures of up to 150 MPa. The operation of the main systems of the target is described: generation and purification of deuterium gas, refrigeration, heating, evacuation, automated control system and data collection system

  8. Target Window Reliability

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-02-11

    The target window design implemented and tested in experiments at ANL have performed without failure for the available beam of 6 mm FWHM on a 12 mm diameter target. However, scaling that design to a 25 mm diameter target size for a 12 mm FWHM beam has proven problematic. Combined thermal and mechanical (pressure induced) stresses and strains are too high to maintain the small coolant gaps and provide adequate fatigue lifetime.

  9. The ISOLDE target robots

    CERN Multimedia

    Maximilein Brice

    2002-01-01

    ISOLDE targets need to be changed frequently, around 80 times per year. The high radiation levels do not permit this to be done by human hands and the target changes are effected by 2 industrial robots (picture _01). On the left, in the distance, the front-end of the GPS (General Purpose Separator) is seen, while the HRS (High Resolution Separator) is at the right. Also seen are the doors to the irradiated-target storage.

  10. Targeted Radionuclide Therapy

    Directory of Open Access Journals (Sweden)

    David Cheng

    2011-10-01

    Full Text Available Targeted radiotherapy is an evolving and promising modality of cancer treatment. The killing of cancer cells is achieved with the use of biological vectors and appropriate radionuclides. Among the many advantages of this approach are its selectiveness in delivering the radiation to the target, relatively less severe and infrequent side effects, and the possibility of assessing the uptake by the tumor prior to the therapy. Several different radiopharmaceuticals are currently being used by various administration routes and targeting mechanisms. This article aims to briefly review the current status of targeted radiotherapy as well as to outline the advantages and disadvantages of radionuclides used for this purpose.

  11. Bayesian multiple target tracking

    CERN Document Server

    Streit, Roy L

    2013-01-01

    This second edition has undergone substantial revision from the 1999 first edition, recognizing that a lot has changed in the multiple target tracking field. One of the most dramatic changes is in the widespread use of particle filters to implement nonlinear, non-Gaussian Bayesian trackers. This book views multiple target tracking as a Bayesian inference problem. Within this framework it develops the theory of single target tracking, multiple target tracking, and likelihood ratio detection and tracking. In addition to providing a detailed description of a basic particle filter that implements

  12. Target Assembly Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Target Assembly Facility integrates new armor concepts into actual armored vehicles. Featuring the capability ofmachining and cutting radioactive materials, it...

  13. Targeting the tumor microenvironment

    Energy Technology Data Exchange (ETDEWEB)

    Kenny, P.A.; Lee, G.Y.; Bissell, M.J.

    2006-11-07

    Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have been proposed. The FDA has already approved drugs targeting microenvironmental components such as VEGF and aromatase and many more agents are in the pipeline. In this article, we describe some of the 'druggable' targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions.

  14. Pulse radiolysis studies of liquid heavy water at temperatures up to 250 degrees C

    Energy Technology Data Exchange (ETDEWEB)

    Stuart, C.R.; Ouellette, D.C.; Elliot, A.J

    2002-09-01

    This report documents the rate constants and associated activation energies for the reactions of the primary radical species, e{sub aq}{sup -}, {center_dot}OD and {center_dot}D, which are formed during the radiolysis of heavy water within the temperature range 20 to 250 {sup o}C. These heavy-water data have been compared with the corresponding information for light water. These kinetic data form part of the database that is required to model the aqueous radiation chemistry that occurs within the core of the heavy water cooled and moderated CANDU reactor. (author)

  15. DIGITALNA TOPOGRAFSKA KARTA 1:250 000 – PREMA NATO STANDARDIMA

    OpenAIRE

    Mirko Borisov

    2007-01-01

    U radu se iznose iskustva pri izradi i oblikovanju vojne topografske karte razmera 1: 250 000. Karta se izrađuje u Vojnogeografskom institutu, po NATO standardima i u digitalnom obliku. Iskustva drugih država u kreiranju vojnih topografsko-kartografskih sistema i karata mogu se uporediti sa našim. Postupci izrade i ažuriranja vojnih topografskih karata su informatički podržani uz veliki stepen automatizacije pojedinih faza njihove izrade i osavremenjavanja.

  16. A 250-GHz CARM [Cyclotron Auto Resonance Maser] oscillator experiment driven by an induction linac

    International Nuclear Information System (INIS)

    A 250-GHz Cyclotron Auto Resonance Maser (CARM) oscillator has been designed and constructed and will be tested using a 1-kA, 2-MeV electron beam produced by the induction linac at the Accelerator Research Center (ARC) facility of Lawrence Livermore National Laboratory (LLNL). The oscillator circuit was made to operate in the TE11 mode at ten times cutoff using waveguide Bragg reflectors to create an external cavity Q of 8000. Theory predicts cavity fill times of less than 30 ns (pulse length) and efficiencies approaching 20% is sufficiently low transverse electron velocity spreads are maintained (2%)

  17. A kinetic-phase transformation near 250 K in potassium tetrachlorozincate

    International Nuclear Information System (INIS)

    Raman-scattering experiments have been performed to study the successive phase transitions of K2ZnCl4 over the temperature range (100/600) K. The spectra provide the temperature dependence of the mode frequencies and linewidths for two different spatial configurations: a(bb) c and c(aa) b. Special emphasis is put upon a new phenomenon observed in the spectra around 250 K in the c*/3 superstructure. Its kinetic character is revealed by complementary DSC measurements carried out over the range (120/300) K. This phenomenon is interpreted as a progressive structural transformation which corresponds to a slow modification of the tetrahedron distortions. (orig.)

  18. TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution

    DEFF Research Database (Denmark)

    Samuelsen, Camilla O; Baraznenok, Vera; Khorosjutina, Olga;

    2003-01-01

    In Saccharomyces cerevisiae Mediator, a subgroup of proteins (Srb8, Srb9, Srb10, and Srb11) form a module, which is involved in negative regulation of transcription. Homologues of Srb10 and Srb11 are found in some mammalian Mediator preparations, whereas no clear homologues have been reported for...... Srb8 and Srb9. Here, we identify a TRAP240/ARC250 homologue in Schizosaccharomyces pombe and demonstrate that this protein, spTrap240, is stably associated with a larger form of Mediator, which also contains conserved homologues of Srb8, Srb10, and Srb11. We find that spTrap240 and Sch. pombe Srb8 (sp...

  19. pUR 250 allows rapid chemical sequencing of both DNA strands of its inserts.

    OpenAIRE

    Rüther, U

    1982-01-01

    A multipurpose plasmid, pUR 250, has been constructed. It contains seven unique cloning sites (Hind III, Xba I, Sal I, Acc I, Hinc II, BamH I and EcoR I) in a small region of its lac Z gene part. Insertion of foreign DNA into the plasmid can be easily detected. Plasmid DNA isolated from a clone by a rapid method can be used to determine the DNA sequence of the insert from both ends directly without isolation of labeled fragment.

  20. High speed (<= 250 ps) high gain X-ray shutter camera

    International Nuclear Information System (INIS)

    A high speed X-ray shutter tube has been developed for laser induced plasma imaging. The limiting exposure time is in the 250 ps range and 5 images can be recorded on the same, laser shot, in order to provide a 5 spectral channel analysis of the plasma. A high light gain is obtained from a microchannel plate inserted in the 50Ω transmission line, which provide the adapted structure to reach such a time exposure. We present the main performances of this camera

  1. Dynamic nuclear polarization at 9 T using a novel 250 GHz gyrotron microwave source

    OpenAIRE

    Bajaj, V. S.; Farrar, C. T.; Hornstein, M.K.; Mastovsky, I.; Vieregg, J.; Bryant, J; Eléna, B.; Kreischer, K.E.; Temkin, R.J.; Griffin, R G

    2003-01-01

    In this communication, we report enhancements of nuclear spin polarization by dynamic nuclear polarization (DNP) in static and spinning solids at a magnetic field strength of 9 T (250 GHz for g = 2 electrons, 380 MHz for [superscript 1]H). In these experiments, [superscript 1]H enhancements of up to 170 ± 50 have been observed in 1-[superscript 13]C-glycine dispersed in a 60:40 glycerol/water matrix at temperatures of 20 K; in addition, we have observed significant enhancements in [superscrip...

  2. An investigation into the influence of female directors on audit effort: Evidence from FTSE 250

    OpenAIRE

    Li, Yue

    2013-01-01

    This study is conducted in order to detect if the female directors on board would have influence on the oversight function of the whole board and finally influence the audit fee. The motivation of this study is the increasing number of the female members in the workplace as well as the increasing number of female directors on board. This study focus on the UK market, so the data used in this paper is derived from FTSE 250 and the major methodology adopted in the empirical study is OLS regress...

  3. Alkaline electrolysis cell at high temperature and pressure of 250 °C and 42 bar

    DEFF Research Database (Denmark)

    Allebrod, Frank; Chatzichristodoulou, Christodoulos; Mogensen, Mogens Bjerg

    2013-01-01

    A new type of alkaline electrolysis cells with nickel foam based gas diffusion electrodes and KOH (aq) immobilized in mesoporous SrTiO3 has been developed and tested at temperatures and pressures up to 250 °C and 42 bar, respectively. Current densities of 1.0 A cm−2 have been measured at a cell...... voltage of 1.5 V without the use of expensive noble metal catalysts. High electrical efficiency and current density combined with relatively small production costs may lead to both reduced investment and operating costs for hydrogen and oxygen production....

  4. The CNGS target

    CERN Multimedia

    Patrice Loïez

    2005-01-01

    The CERN Neutrinos to Gran Sasso (CNGS) target ‘magazine’ of five target units. Each unit contains a series of 10-cm long graphite rods distributed over a length of 2 m. It is designed to maximize the number of secondary particles produced and hence the number of neutrinos. One unit is used at a time to prevent over heating.

  5. Strategic Targeted Advertising

    NARCIS (Netherlands)

    A. Galeotti; J.L. Moraga-Gonzalez (José Luis)

    2003-01-01

    textabstractWe present a strategic game of pricing and targeted-advertising. Firms can simultaneously target price advertisements to different groups of customers, or to the entire market. Pure strategy equilibria do not exist and thus market segmentation cannot occur surely. Equilibria exhibit rand

  6. Radiation damage studies on STAR250 CMOS sensor at 300 keV for electron microscopy

    Science.gov (United States)

    Faruqi, A. R.; Henderson, R.; Holmes, J.

    2006-09-01

    There is a pressing need for better electronic detectors to replace film for recording high-resolution images using electron cryomicroscopy. Our previous work has shown that direct electron detection in CMOS sensors is promising in terms of resolution and efficiency at 120 keV [A.R. Faruqi, R. Henderson, M. Prydderch, R. Turchetta, P. Allport, A. Evans, Nucl. Instr. and Meth. 546 (2005) 170], but in addition, the detectors must not be damaged by the electron irradiation. We now present new measurements on the radiation tolerance of a 25 μm pitch CMOS active-pixel sensor, the STAR250, which was designed by FillFactory using radiation-hard technology for space applications. Our tests on the STAR250 aimed to establish the imaging performance at 300 keV following irradiation. The residual contrast, measured on shadow images of a 300 mesh grid, was >80% after corrections for increased dark current, following irradiation with up to 5×10 7 electrons/pixel (equivalent to 80,000 electron/μm 2). A CMOS sensor with this degree of radiation tolerance would survive a year of normal usage for low-dose electron cryomicroscopy, which is a very useful advance.

  7. Particle production in hadron-proton interactions at 250 GeV/c incident beam momentum

    International Nuclear Information System (INIS)

    In this thesis several characteristic properties are described of π+p, K+p and pp collisions at an incident beam momentum of 250 GeV/c, and compared to characteristics of other energy. The experiment has been performed in the European Hybrid Spectrometer (EHS) exposed to a tagged meson enriched beam. The rapid cycling bubble-chamber and the other detector elements which comprise EHS are described in Ch. 2. Events used for the analysis have been scanned, measured and merged with the electronic counter information. After the merge steps the data have been processed through a chain of reconstruction programs (Ch. 3). In Ch. 4 the multiplicity distributions and topological cross sections are presented. An introduction to the models (Monte Carlo programs) is given in Ch. 5. In Ch. 6 the characteristics of charged particle production in π+p, K+p and pp collisions at 250 GeV/c are presented. In Ch. 7 the forward π0 production is presented, a study of rho and omega resonance production in the forward hemisphere in Ch. 8. In Ch. 6, 7 and 8, the data are compared to predictions from the Monte Carlo programs described in Ch. 5. 117 refs.; 70 figs.; 23 tabs

  8. Microstructure and Hardness of T250 Maraging Steel in Heat Affected Zone

    Institute of Scientific and Technical Information of China (English)

    MO De-feng; HU Zheng-fei; CHEN Shu-juan; WANG Chun-xu; HE Guo-qiu

    2009-01-01

    Electron-beam (EB) welding was used in T250 maraging steel,microstructures of both base material and heat affected zone (HAZ) were investigated by optical microscopy (OM),scanning electron microscopy (SEM) and transmission electron microscopy (TEM),and microhardness was tested.The results showed that during EB welding,the HAZ of T250 maraging steel exhibited a continuous gradient structure.The microstructure of the entire HAZ,from fusion line,could be divided into four zones:fusion zone,overheated zone,transition zone,and hardened zone.The microhardness showed a distinct regularity in each area.The softest region was the fusion zone,whereas the hardest was the hardened zone.In the overheated zone,the hardness increased as the grain size decreased.Furthermore,in the transition zone,the hardness level dropped noticeably.The peak temperature during the thermal cycle had a great influence on the formation of reverted austenite and dissolution of the precipitated particles,which contributed a lot to the microstrueture and hardness of this material.

  9. Molecular gas kinematics within the central 250 pc of the Milky Way

    CERN Document Server

    Henshaw, J D; Kruijssen, J M D; Davies, B; Bally, J; Barnes, A; Battersby, C; Burton, M; Cunningham, M R; Dale, J E; Ginsburg, A; Immer, K; Jones, P A; Kendrew, S; Mills, E A C; Molinari, S; Moore, T J T; Ott, J; Pillai, T; Rathborne, J; Schilke, P; Schmiedeke, A; Testi, L; Walker, D; Walsh, A; Zhang, Q

    2016-01-01

    Using spectral-line observations of HNCO, N2H+, and HNC, we investigate the kinematics of dense gas in the central ~250 pc of the Galaxy. We present SCOUSE (Semi-automated multi-COmponent Universal Spectral-line fitting Engine), a line fitting algorithm designed to analyse large volumes of spectral-line data efficiently and systematically. Unlike techniques which do not account for complex line profiles, SCOUSE accurately describes the {l, b, v_LSR} distribution of CMZ gas, which is asymmetric about Sgr A* in both position and velocity. Velocity dispersions range from 2.6 km/s28. The gas is distributed throughout several "streams", with projected lengths ~100-250 pc. We link the streams to individual clouds and sub-regions, including Sgr C, the 20 and 50 km/s clouds, the dust ridge, and Sgr B2. Shell-like emission features can be explained by the projection of independent molecular clouds in Sgr C and the newly identified conical profile of Sgr B2 in {l ,b, v_LSR} space. These features have previously invoked...

  10. Temperature variation and its driving forces over the Antarctic coastal regions in the past 250 years

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    By comparing the oxygen isotopic temperatures recorded by many shallow ice cores fromthe coastal regions of Antarctica, this paper presents the special characteristics of the temperaturevariations over the Antarctic coastal regions in the past 50 years, 150 years and 250 years. In thepast 50 years, the isotopic temperatures recorded in the ice cores over different sites on the Antarcticcoastal regions differ greatly. For instance, although increasing isotopic temperatures have beenreported for many sites studied, many sites show decreasing trends, the regional regularity intemperature variations is still insignificant. In the past 150 years, the isotopic temperature trends inthe coastal regions of Antarctica show an alternate-distributing pattern. In the past 250 years, all theice cores from the coastal regions of Antarctica have recorded the so-called Little Ice Age (LIA). Theabove-mentioned spatial characteristics of the temperature variations over the Antarctic coastalregions are likely to reflect the impacts of the unique Southern Hemisphere atmospheric circulation,the Antarctic Circumpolar Wave (ACW) and the special terrain (such as the large drainage basins) onthe coastal regions of Antarctica. Furthermore, the impacting intensity of the unique SouthernHemisphere atmospheric circulation, the Antarctic Circumpolar Wave and the special terrain differs interms of the temporal scale of the temperature change.

  11. Dynamic nuclear polarization at 9 T using a novel 250 GHz gyrotron microwave source

    Science.gov (United States)

    Bajaj, V. S.; Farrar, C. T.; Hornstein, M. K.; Mastovsky, I.; Vieregg, J.; Bryant, J.; Eléna, B.; Kreischer, K. E.; Temkin, R. J.; Griffin, R. G.

    2011-12-01

    In this communication, we report enhancements of nuclear spin polarization by dynamic nuclear polarization (DNP) in static and spinning solids at a magnetic field strength of 9 T (250 GHz for g = 2 electrons, 380 MHz for 1H). In these experiments, 1H enhancements of up to 170 ± 50 have been observed in 1- 13C-glycine dispersed in a 60:40 glycerol/water matrix at temperatures of 20 K; in addition, we have observed significant enhancements in 15N spectra of unoriented pf1-bacteriophage. Finally, enhancements of ˜17 have been obtained in two-dimensional 13C- 13C chemical shift correlation spectra of the amino acid U- 13C, 15N-proline during magic angle spinning (MAS), demonstrating the stability of the DNP experiment for sustained acquisition and for quantitative experiments incorporating dipolar recoupling. In all cases, we have exploited the thermal mixing DNP mechanism with the nitroxide radical 4-amino-TEMPO as the paramagnetic dopant. These are the highest frequency DNP experiments performed to date and indicate that significant signal enhancements can be realized using the thermal mixing mechanism even at elevated magnetic fields. In large measure, this is due to the high microwave power output of the 250 GHz gyrotron oscillator used in these experiments.

  12. Properties of compact 250 \\mu m emission and HII regions in M33 (HERM33ES)

    CERN Document Server

    Verley, S; Kramer, C; Xilouris, E M; Boquien, M; Calzetti, D; Combes, F; Buchbender, C; Braine, J; Quintana-Lacaci, G; Tabatabaei, F S; Lord, S; Israel, F; Stacey, G; van der Werf, P

    2010-01-01

    Within the framework of the HERM33ES Key Project, using the high resolution and sensitivity of the Herschel photometric data, we study the compact emission in the Local Group spiral galaxy M33 to investigate the nature of the compact SPIRE emission sources. We extracted a catalogue of sources at 250um in order to investigate the nature of this compact emission. Taking advantage of the unprecedented Herschel resolution at these wavelengths, we also focus on a more precise study of some striking Halpha shells in the northern part of the galaxy. We present a catalogue of 159 compact emission sources in M33 identified by SExtractor in the 250um SPIRE band that is the one that provides the best spatial resolution. We also measured fluxes at 24um and Halpha for those 159 extracted sources. The morphological study of the shells also benefits from a multiwavelength approach including Halpha, far-UV from GALEX, and infrared from both Spitzer IRAC 8um and MIPS 24um in order to make comparisons. For the 159 compact sour...

  13. First polarized proton collision at a beam energy of 250 GeV in RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Bai,M.; Ahrens, L.; Alekseev, I. G.; Alessi, J.; et al.

    2009-05-04

    After providing collisions of polarized protons at a beam energy of 100 GeV since 2001, the Relativistic Heavy Ion Collider (RHIC) at BNL had its first opportunity to collide polarized protons at its maximum beam energy of 250 GeV in the 2009 polarized proton operations. Equipped with two full Siberian snakes [1] in each ring, RHIC preserves polarization during acceleration from injection to 100 GeV with precise control of the betatron tunes and vertical orbit distortions. However, the strong intrinsic spin resonances beyond 100 GeV are more than two times stronger than those below 100 GeV, requiring much tighter tolerances on vertical orbit distortions and betatron tunes. With the currently achieved orbit correction and tune control, average polarizations of {approx_equal} 42% at top energy and average polarizations of {approx_equal} 55% at injection energy were achieved. Polarization measurements as a function of beam energy also indicated aU polarization losses occurred around three strong intrinsic resonances at 136 GeV, 199.3 GeV and 220.8 GeV Peak luminosity of 122 x 10{sup 30} cm{sup -2} s{sup -1} was also demonstrated. This paper presents the performance of the first RHIC 250 GeV operation and discusses the depolarization issues encountered during the run.

  14. Cooling system upgrading from 250 kW to 1 MW

    International Nuclear Information System (INIS)

    The Oregon State TRIGA reactor (OSTR) power capability was upgraded from 250 KW to 1 MW in 1969; however, funds were not available for simultaneous upgrading of the cooling system. Since then, the OSTR has been selectively operating at full power with the original 250 KW cooling system. After funds were made available in 1971 the construction on the new heat exchanger building began. The new cooling system was installed, equipment was checked out, corrections were made, and acceptance tests were run. In addition, several days were required to clean up the primary system water, since increased water flow (350 gpm) swirled 4 year's collection of sediment off the reactor tank bottom and into the primary system. Three interesting items have been noticed, which are apparently a result of the cooling system upgrading: (1) the radiation levels above the reactor tank have been reduced by a factor of 2 to 3, (2) a low resonance vibration in the reactor core occurs at 1 MW. The vibration is attributed to a combination of increased water turbulence and subcooled (surface) nucleate boiling, and (3) direct radiation levels from the demineralizer tank have increased approximately 8-fold. This resulted in a relocation of the tank and the use of supplemental shielding. Increased operating time at higher average power levels, plus disturbance of; sediment on the bottom of the reactor tank are believed to be the main sources of the higher radiation levels

  15. Clinicopathological analysis of 250 patients with early-stage gastric cancer%250例早期胃癌临床病理分析

    Institute of Scientific and Technical Information of China (English)

    钱建忠; 赵可; 李世兰; 徐洪明

    2010-01-01

    Objective To explore the factors associated with early diagnosis of gastric cancer.Methods Clinical data were retrospectively analyzed for 250 patients with early-stage gastric cancer (EGG) from 2005 to 2008, during which the concept of intra-epithelial neoplasia(IN) was adopted in our department. Results On preoperative endoscopic biopsy with pathological exam, there were 15 cases suspicious for cancer, 90 with high-grade IN(HGIN), and 15 gastric cancer. Postoperative pathological exam of the surgical specimen showed infiltrating early-stage cancer in 224 patients, of which 5(2.2%) were type Ⅰ(all were Tsm), 190 (84.8%) were type Ⅱ including Tm in 82 and Tsm in 108 patients, 29 were type Ⅲ (5 Tm and 24 Tsm). Twenty-six patients had non-infiltrating lesions(Tis).There were 184(73.6%)well-differentiated tumors, including 26 Tis, 58 Tm, and 100 Tsm. Lymphatic metastasis was identified in 21 patients, of which 2(2.3%) were Tin(all were poorly-differentiated) and 19 (13.9%) were Tsm. Lymphadenopathy was present in 15(7.9%) cases in type Ⅱ, and in 6(20.7%) in type Ⅲ. of the 90 cases with a preoperative diagnosis of HGIN, 24 were found to be Tis, 29 were Tin, and 37 were Tsm on postoperative pathological assessment. Conclusions Well-differentiation is the main histological type in EGC. The adoption of the concept of IN is associated with improved detection of EGC, which warrants further investigation.%目的 探讨进一步提高早期胃癌诊断水平的因素.方法 对2005-2008年间应用上皮内瘤变(IN)的概念诊断的250例早期胃癌患者的病理资料进行分析.结果 本组患者术前内镜活检诊断可疑癌15例,高级别上皮内瘤变(HGIN)90例,胃癌145例.术后病理诊断浸润型早期胃癌224例,其中Ⅰ型5例(2.2%),均为黏膜下癌(Tsm)患者;Ⅱ型190例(84.8%),有82例为黏膜内癌(Tm),108例为Tsm;Ⅲ型29例,5例Tm,24例Tsm.未浸润性病变(Tis)26例.以高分化为主要组织学类型者184例(73.6%),其中26

  16. Targeted therapy in lymphoma

    Directory of Open Access Journals (Sweden)

    Cavalli Franco

    2010-11-01

    Full Text Available Abstract Discovery of new treatments for lymphoma that prolong survival and are less toxic than currently available agents represents an urgent unmet need. We now have a better understanding of the molecular pathogenesis of lymphoma, such as aberrant signal transduction pathways, which have led to the discovery and development of targeted therapeutics. The ubiquitin-proteasome and the Akt/mammalian target of rapamycin (mTOR pathways are examples of pathological mechanisms that are being targeted in drug development efforts. Bortezomib (a small molecule protease inhibitor and the mTOR inhibitors temsirolimus, everolimus, and ridaforolimus are some of the targeted therapies currently being studied in the treatment of aggressive, relapsed/refractory lymphoma. This review will discuss the rationale for and summarize the reported findings of initial and ongoing investigations of mTOR inhibitors and other small molecule targeted therapies in the treatment of lymphoma.

  17. Effect of JWH-250, JWH-073 and their interaction on "tetrad", sensorimotor, neurological and neurochemical responses in mice.

    Science.gov (United States)

    Ossato, Andrea; Canazza, Isabella; Trapella, Claudio; Vincenzi, Fabrizio; De Luca, Maria Antonietta; Rimondo, Claudia; Varani, Katia; Borea, Pier Andrea; Serpelloni, Giovanni; Marti, Matteo

    2016-06-01

    JWH-250 and JWH-073 are two synthetic cannabinoid agonists with nanomolar affinity at CB1 and CB2 receptors. They are illegally marketed within "herbal blend" for theirs psychoactive effects greater than those produced by Cannabis. Recently, we analyzed an "herbal" preparation containing a mixture of both JWH-250 and JWH-073. The present study was aimed at investigating the in vitro and in vivo pharmacological activity of JWH-250 and JWH-073 in male CD-1 mice. In vitro competition binding experiments performed on mouse and human CB1 and CB2 receptors revealed a nanomolar affinity and potency of the JWH-250 and JWH-073. In vivo studies showed that JWH-250 and JWH-073, administered separately, induced a marked hypothermia, increased pain threshold to both noxious mechanical and thermal stimuli, caused catalepsy, reduced motor activity, impaired sensorimotor responses (visual, acoustic and tactile), caused seizures, myoclonia, hyperreflexia and promote aggressiveness in mice. Moreover, microdialysis study in freely moving mice showed that systemic administration of JWH-250 and JWH-073 stimulated dopamine release in the nucleus accumbens in a dose-dependent manner. Behavioral, neurological and neurochemical effects were fully prevented by the selective CB1 receptor antagonist/inverse agonist AM 251. Co-administration of ineffective doses of JWH-250 and JWH-073 impaired visual sensorimotor responses, improved mechanical pain threshold and stimulated mesolimbic DA transmission in mice, living unchanged all other behavioral and physiological parameters. For the first time the present study demonstrates the overall pharmacological effects induced by the administration of JWH-250 and JWH-073 in mice and it reveals their potentially synergistic action suggesting that co-administration of different synthetic cannabinoids may potentiate the detrimental effects of individual compounds increasing their dangerousness and abuse potential. PMID:26780169

  18. 基于PLC的XS-ZY250A注塑机控制系统设计

    Institute of Scientific and Technical Information of China (English)

    魏强

    2010-01-01

    为改善注塑机传统电气控制存在的局限性和不足,采用西门子S7-300型系列PLC对XS-ZY250A普通卧式注塑机控制系统进行改造.阐述了PLC控制系统程序设计,给出了XS-ZY250A注塑机的PLC控制梯形图.

  19. 时速250km以上高速列车制动模式曲线算法%Braking mode curve arithmetic of high-speed train above 250 km · h-1

    Institute of Scientific and Technical Information of China (English)

    上官伟; 蔡伯根; 王晶晶; 王剑; 王利

    2011-01-01

    The braking system of high-speed train above 250 km ? H-1 was studied, and the running resistance, braking force and braking distance of high-speed train were analyzed. Based on curve theory of target distance mode, the piecewise iteration model of braking mode curve for high-speed train was proposed. With MATLAB/Simulink software, the changes of running resistances on flat-straight line, direct ramp with grade 15%o and direct ramp with grade 25‰ for CRH2-300 type high-speed train were analyzed, and the normal braking curves and emergency braking curves of CRH2-300 type and CRH3 type high-speed trains at initial braking speed 300 km ? H-1 were compared. Calculation result indicates that the emergency braking distance of CRH2-300 type high-speed train is 2 786. 68 m on direct ramp, the emergency braking distance of CRH3 type high-speed train is 3 319. 37 m on direct ramp, and both of them are less than 3 700 m, which is the maximum braking distance of braking requirement. Simulation braking curves almost consistent with actual braking curves, which verifies the validity of piecewise iteration algorithm. 1 tab, 12 figs, 10 refs.%研究了时速250 km以上高速列车制动系统,分析了高速列车的运行阻力、制动力与制动距离.根据目标距离模式曲线理论,建立了高速列车的制动模式曲线分段迭代模型.应用MAT-LAB/Simulink软件,分析了CRH2-300型高速列车在平直道上、15‰与25‰直坡道上的运行阻力的变化,对比了CRH2-300型和CRH3型高速列车在制动初速为300 km·h-1时的常用和紧急制动曲线.计算结果表明:在平直道上,CRH2-300型高速列车紧急制动距离为2 786.68 m,CRH3型高速列车紧急制动距离为3 319.37 m,均满足紧急制动距离小于3 700 m的制动要求;仿真制动曲线和实际制动曲线基本一致,验证了分段迭代算法的有效性.

  20. Nuclear target development

    Energy Technology Data Exchange (ETDEWEB)

    Greene, J.P.; Thomas, G.E.

    1995-08-01

    The Physics Division operates a target development laboratory that produces thin foil targets needed for experiments performed at the ATLAS and Dynamitron accelerators. Targets are not only produced for the Physics Division but also for other divisions and occasionally for other laboratories and universities. In the past year, numerous targets were fabricated by vacuum evaporation either as self-supporting foils or on various substrates. Targets produced included Ag, Au, {sup 10,11}B, {sup 138}Ba, Be, {sup 12}C, {sup 40}Ca, {sup 116}Cd, {sup 155,160}Gd, {sup 76}Ge, In, LID, {sup 6}LiH, Melamine, Mg, {sup 142,150}Nd, {sup 58}Ni, {sup 206,208}Pb, {sup 194}Pt, {sup 28}Si, {sup 144,148}Sm, {sup 120,122,124}Sn, Ta, {sup 130}Te, ThF{sub 4}, {sup 46,50}Ti, TiH, U, UF{sub 4}, {sup 182}W and {sup 170}Yb. Polypropylene and aluminized polypropylene, along with metallized Mylar were produced for experiments at ATLAS. A number of targets of {sup 11}B of various thickness were made for the DEP 2-MeV Van de Graff accelerator. An increased output of foils fabricated using our small rolling mill included targets of Au, C, {sup 50}Cr, Cu, {sup 155,160}Gd, Mg, {sup 58}Ni, {sup 208}Pb, {sup 105,110}Pd. Sc, Ti, and {sup 64,66}Zn.

  1. AA antiproton production target

    CERN Multimedia

    1979-01-01

    The first version of the antiproton production target was a tungsten rod, 11 cm long and 3 mm in diameter. The rod was embedded in graphite, pressure-seated into an outer casing of stainless steel. At the entrance to the target assembly was a scintillator screen, imprinted with circles every 5 mm in radius, which allowed to precisely aim the 26 GeV high-intensity proton beam from the PS onto the centre of the target rod. The scintillator screen was a 1 mm thick plate of Cr-doped alumina. See also 7903034 and 7905091.

  2. Internal polarized targets

    Energy Technology Data Exchange (ETDEWEB)

    Kinney, E.R.; Coulter, K.; Gilman, R.; Holt, R.J.; Kowalczyk, R.S.; Napolitano, J.; Potterveld, D.H.; Young, L. (Argonne National Lab., IL (USA)); Mishnev, S.I.; Nikolenko, D.M.; Popov, S.G.; Rachek, I.A.; Temnykh, A.B.; Toporkov, D.K.; Tsentalovich, E.P.; Wojtsekhowski, B.B. (AN SSSR, Novosibirsk (USSR). Inst. Yadernoj Fiziki)

    1989-01-01

    Internal polarized targets offer a number of advantages over external targets. After a brief review of the basic motivation and principles behind internal polarized targets, the technical aspects of the atomic storage cell will be discussed in particular. Sources of depolarization and the means by which their effects can be ameliorated will be described, especially depolarization by the intense magnetic fields arising from the circulating particle beam. The experience of the Argonne Novosibirsk collaboration with the use of a storage cell in a 2 GeV electron storage ring will be the focus of this technical discussion. 17 refs., 11 figs.

  3. STIS target acquisition

    Science.gov (United States)

    Kraemer, Steve; Downes, Ron; Katsanis, Rocio; Crenshaw, Mike; McGrath, Melissa; Robinson, Rich

    1997-01-01

    We describe the STIS autonomous target acquisition capabilities. We also present the results of dedicated tests executed as part of Cycle 7 calibration, following post-launch improvements to the Space Telescope Imaging Spectrograph (STIS) flight software. The residual pointing error from the acquisitions are < 0.5 CCD pixels, which is better than preflight estimates. Execution of peakups show clear improvement of target centering for slits of width 0.1 sec or smaller. These results may be used by Guest Observers in planning target acquisitions for their STIS programs.

  4. Estimating wide range Total Suspended Solids concentrations from MODIS 250-m imageries: An improved method

    Science.gov (United States)

    Chen, Shuisen; Han, Liusheng; Chen, Xiuzhi; Li, Dan; Sun, Lin; Li, Yong

    2015-01-01

    The objective of this study was to evaluate the performance of moderate resolution imaging spectroradiometer (MODIS) 250 m based TSS (Total Suspended Solids) retrieval model for developing the model of wide-range TSS concentrations. Using field spectral and TSS data (5.8-577.2 mg/l) collected from estuary and coast of China, we calibrated (N = 40) and validated (N = 20) the 6 TSS retrieval models in forms of single band (B1 or B2), difference of the two bands, sediment index, band ratio and log-ratio by the least-squares technique. Results showed that the quadratic model of log-ratio is of the best accuracy (Calibration: R2 = 0.752, N = 40. Validation: TSS > 31 mg/l, RMSE = 37.9 mg/l, N = 12; TSS ⩽ 31mg /l, RMSE = 3.25 mg/l, N = 8). We also found that the spectral log-ratio values increased with the increasing of TSS when TSS 31 mg/l. The findings of quadratic curve vertex (log-ratio: ∼1.58) in the proposed TSS model indicated that the spectral log-ratio may be sensitive to TSS of both low and high concentrations. We further applied the preferred model to retrieve TSS concentration from the MODIS 250-m images in turbid estuarial and clear coastal waters, and obtained a good mapping accuracy from the result (TSS > 31 mg/l: RMSE = 38.6 mg/l, MRE = 24.7%, N = 17; TSS ⩽ 31mg /l : RMSE = 2.1 mg/l, MRE = 19.5%, N = 11). The vertex-based methodology of TSS model developed in the study is applicable in mapping TSS concentrations that are of a wide range variation in estuarine and coastal water bodies based on MODIS 250-m image, and as well to maximize its application potential due to high imaging frequency (two times during daytime) and appropriate space resolution of MODIS images. Therefore, the method can be used to detect the high temporal variability of TSS during tidal cycle. As such, the application of MODIS-water quality detection technology can be extended to coastal sediment movement.

  5. Target Price Accuracy

    Directory of Open Access Journals (Sweden)

    Alexander G. Kerl

    2011-04-01

    Full Text Available This study analyzes the accuracy of forecasted target prices within analysts’ reports. We compute a measure for target price forecast accuracy that evaluates the ability of analysts to exactly forecast the ex-ante (unknown 12-month stock price. Furthermore, we determine factors that explain this accuracy. Target price accuracy is negatively related to analyst-specific optimism and stock-specific risk (measured by volatility and price-to-book ratio. However, target price accuracy is positively related to the level of detail of each report, company size and the reputation of the investment bank. The potential conflicts of interests between an analyst and a covered company do not bias forecast accuracy.

  6. Targeted therapies for cancer

    Science.gov (United States)

    ... to be untrue. Possible side effects from targeted therapies include: Diarrhea Liver problems Skin problems such as rash, dry skin, and nail changes Problems with blood clotting and wound healing High blood pressure As with any treatment, you ...

  7. Design and development of collector for C-band 250 kW CW Klystron

    International Nuclear Information System (INIS)

    The paper presents the design and development of collector for C-band 250 kW high power klystron. The design criteria for the collector assembly is selection of material, vacuum and high temperature compatibility, proper electron beam dispersion, minimum back scattering of electrons and thermal design for proper cooling at high power dissipation. All these aspects have been discussed for collector development in details. The collector has been designed in TRAK and then beam propagation has been analyzed in MAGIC 2D software. The thermal simulation has been done using ANSYS 11.0 (multi-physics). The outer surface of the collector has been grooved to facilitate its proper cooling. Design results are presented for water cooling with different flow rates and channel dimensions. OFHC copper material is chosen for collector which is suitable for vacuum and hydrogen brazing operations and good thermal properties for efficient cooling.

  8. A 250 GHz gyrotron with a 3 GHz tuning bandwidth for dynamic nuclear polarization.

    Science.gov (United States)

    Barnes, Alexander B; Nanni, Emilio A; Herzfeld, Judith; Griffin, Robert G; Temkin, Richard J

    2012-08-01

    We describe the design and implementation of a novel tunable 250 GHz gyrotron oscillator with >10 W output power over most of a 3 GHz band and >35 W peak power. The tuning bandwidth and power are sufficient to generate a >1 MHz nutation frequency across the entire nitroxide EPR lineshape for cross effect DNP, as well as to excite solid effect transitions utilizing other radicals, without the need for sweeping the NMR magnetic field. Substantially improved tunability is achieved by implementing a long (23 mm) interaction cavity that can excite higher order axial modes by changing either the magnetic field of the gyrotron or the cathode potential. This interaction cavity excites the rotating TE(₅,₂,q) mode, and an internal mode converter outputs a high-quality microwave beam with >94% Gaussian content. The gyrotron was integrated into a DNP spectrometer, resulting in a measured DNP enhancement of 54 on the membrane protein bacteriorhodopsin. PMID:22743211

  9. A 250 GHz gyrotron with a 3 GHz tuning bandwidth for dynamic nuclear polarization

    Science.gov (United States)

    Barnes, Alexander B.; Nanni, Emilio A.; Herzfeld, Judith; Griffin, Robert G.; Temkin, Richard J.

    2012-08-01

    We describe the design and implementation of a novel tunable 250 GHz gyrotron oscillator with >10 W output power over most of a 3 GHz band and >35 W peak power. The tuning bandwidth and power are sufficient to generate a >1 MHz nutation frequency across the entire nitroxide EPR lineshape for cross effect DNP, as well as to excite solid effect transitions utilizing other radicals, without the need for sweeping the NMR magnetic field. Substantially improved tunability is achieved by implementing a long (23 mm) interaction cavity that can excite higher order axial modes by changing either the magnetic field of the gyrotron or the cathode potential. This interaction cavity excites the rotating TE5,2,q mode, and an internal mode converter outputs a high-quality microwave beam with >94% Gaussian content. The gyrotron was integrated into a DNP spectrometer, resulting in a measured DNP enhancement of 54 on the membrane protein bacteriorhodopsin.

  10. Circulating fluidized bed combustion ash characterization. The case of the Provence 250 MW unit

    Energy Technology Data Exchange (ETDEWEB)

    Lecuyer, I.; Leduc, M. [Electricite de France (EDF), 78 - Chatou (France). Direction des Etudes et Recherches; Lefevre, R.; Ausset, P. [Paris-12 Univ., Creteil (France). Lab. Interuniversitaire des Systemes Atmospheriques

    1997-05-01

    The Provence 250 MW Circulating Fluidized Bed Combustion Unit (Gardanne, France) is burning a high sulfur (2 to 4%), high ash content (30%) local lignite. This peculiar fuel already contains about 15% of CaO which allows it to capture the sulfur dioxide in situ without adding any complementary sorbent. The ash chemical composition (bed ash and ESP ash) that reflects the particularities of the coal is presented. SEM and DRX observations confirm the presence of anhydrite CaSO{sub 4}, lime, CaS, quartz and traces of hematite. Most of particles are roughly-shaped but microspheres can also be detected in fly ash. The very high sulfate content may be worrying for the environment in disposals. Hardened samples do not seem to retain compounds from leaching: high quantities of calcium and sulfates are still leached from these crushed samples. (author) 10 refs.

  11. Three-dimensional magnetic cloak working from DC to 250 kHz

    CERN Document Server

    Zhu, Jianfei; Liu, Yichao; Yin, Ge; Yuan, Jun; He, Sailing; Ma, Yungui

    2015-01-01

    Invisible cloaking is one of major outcomes of the metamaterial research, but the practical potential, in particular for high frequencies (e.g., microwave to visible light), is fatally challenged by the complex material properties they usually demand. On the other hand, it will be advantageous and also technologically instrumental to design cloaking devices for applications at low frequencies where electromagnetic components are favorably uncoupled. In this work, we vastly develop the bilayer approach to create a three-dimensional magnetic cloak able to work in both static and dynamic fields. Under the quasi-static approximation, we demonstrate a perfect magnetic cloaking device with a large frequency band from zero to 250 kHz. The practical potential of our device is experimentally verified by using a commercial metal detector, which may lead us to having a real cloaking application where the dynamic magnetic field can be manipulated in desired ways.

  12. Structure function scaling in a Reλ = 250 turbulent mixing layer

    KAUST Repository

    Attili, Antonio

    2011-12-22

    A highly resolved Direct Numerical Simulation of a spatially developing turbulent mixing layer is presented. In the fully developed region, the flow achieves a turbulent Reynolds number Reλ = 250, high enough for a clear separation between large and dissipative scales, so for the presence of an inertial range. Structure functions have been calculated in the self-similar region using velocity time series and Taylor\\'s frozen turbulence hypothesis. The Extended Self-Similarity (ESS) concept has been employed to evaluate relative scaling exponents. A wide range of scales with scaling exponents and intermittency levels equal to homogeneous isotropic turbulence has been identified. Moreover an additional scaling range exists for larger scales; it is characterized by smaller exponents, similar to the values reported in the literature for flows with strong shear.

  13. Preequilibrium particle emission in 250 MeV {sup 16}O + {sup 116}Sn reaction

    Energy Technology Data Exchange (ETDEWEB)

    Barlini, S.; Kravchuk, V.L.; Gramegna, F. [INFN, Laboratori Nazionali di Legnaro Padova (Italy)] (and others)

    2005-07-01

    A certain progress in understanding the phenomenon of the Preequilibrium (fast) light charged particle and neutron Emission (PE) was achieved in the last two decades. However, there is a strong need to study systematically the dependence of the PE emission on the reaction mass asymmetry and the projectile energy. In the present work we present the results on the PE proton and alpha-particle multiplicities and the total energy loss of the composite system formed in fusion reaction E{sub b}eam=250 MeV (15.6 MeV/u) {sup 16}O + {sup 116}Sn. The experiment was performed at the Legnaro National Laboratory using a 1 ns (FWHM) pulsed beam provided by the TANDEM-ALPI acceleration system.

  14. Fabrication of 250-nm-hole arrays in glass and fused silica by UV laser ablation

    Science.gov (United States)

    Karstens, R.; Gödecke, A.; Prießner, A.; Ihlemann, J.

    2016-09-01

    Parallel nanohole drilling in glass using an ArF excimer laser (193 nm) is demonstrated. For the first time, hole arrays with 500 nm pitch and individual holes with 250 nm diameter and more than 100 nm depth are fabricated by phase mask imaging using a Schwarzschild objective. Holes in soda lime glass are drilled by direct ablation; fused silica is processed by depositing a SiOx-film on SiO2, patterning the SiOx by ablation, and finally oxidizing the remaining SiOx to SiO2. Thermally induced ordered dewetting of noble metal films deposited on such templates may be used for the fabrication of plasmonic devices.

  15. Evidence for general instability of past climate from a 250-KYR ice-core record

    DEFF Research Database (Denmark)

    Johnsen, Sigfus Johann; Clausen, Henrik Brink; Dahl-Jensen, Dorthe;

    1993-01-01

    decades. Here we present a detailed stable-isotope record for the full length of the Greenland Ice-core Project Summit ice core, extending over the past 250 kyr according to a calculated timescale. We find that climate instability was not confined to the last glaciation, but appears also to have been...... results1,2 from two ice cores drilled in central Greenland have revealed large, abrupt climate changes of at least regional extent during the late stages of the last glaciation, suggesting that climate in the North Atlantic region is able to reorganize itself rapidly, perhaps even within a few...... interglacial seems to have lasted longer than is implied by the deep-sea SPECMAP record4, in agreement with other land-based observations5,6. We suggest that climate instability in the early part of the last interglacial may have delayed the melting of the Saalean ice sheets in America and Eurasia, perhaps...

  16. GaN pnp bipolar junction transistors operated to 250 C

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, A.P.; Dang, G.; Ren, F.; Han, J.; Monier, C.; Baca, A.G.; Cao, X.A.; Cho, H.; Abernathy, C.R.; Pearton, S.J.

    2000-01-03

    The authors report on the dc performance of the first GaN pnp bipolar junction transistor. The structure was grown by MOCVD on c-plane sapphire substrates and mesas formed by low damage Inductively Coupled Plasma etching with a Cl{sub 2}/Ar chemistry. The dc characteristics were measured up to V{sub BC} of 65 V in common base mode and at temperatures up to 250 C. Under all conditions, I{sub C} {approximately} I{sub E}, indicating higher emitter injection efficiency. The offset voltage was {le} 2 V and devices were operated up to power densities of 40kW{center{underscore}dot}cm{sup {minus}2}.

  17. Familiar words capture the attention of 11-month-olds in less than 250 ms.

    Science.gov (United States)

    Thierry, Guillaume; Vihman, Marilyn; Roberts, Mark

    2003-12-19

    The capacity of human infants to discriminate contrasting speech sounds specializes to the native language by the end of the first year of life, when the first signs of word recognition have also been found, using behavioural measures. The extent of voluntary attentional involvement in such word recognition has not been explored, however, nor do we know what its neural time-course may be. Here we demonstrate that 11-month-old children shift their attention automatically to familiar words within 250 ms of presentation onset by measuring event-related potentials elicited by familiar and unfamiliar words. A significant modulation of the first negative peak (N200), known to index implicit change detection in adults, was induced by word familiarity in the infants.

  18. Last 250 years climate reconstruction inferred from geothermal measurements in the Czech Republic

    Science.gov (United States)

    Bodri, L.; Čermák, V.

    1998-06-01

    The subsurface of the Earth has a certain capability to remember what has happened on its surface tens to hundreds of years ago. Ground surface temperature (GST) history, reflecting past climate conditions, can be evaluated by analysing the excursions left on the present-day temperature-depth distribution measured by precise temperature loggings in the boreholes. Temperature logs from fifteen selected holes were inverted into GST histories to assess the corresponding climatic changes. These temperature records generally represent typical conditions existing on the territory of the Czech Republic. In combination with the GST reconstructions from our previous works, these data were used to assess the regional pattern of the last 250-year climatic change. The GSTs were obtained by applying the generalized least-squares inversion method [Jackson, D.D., 1972. Interpretation of inaccurate, insufficient and inconsistent data. Geophys. J. R. Astron. Soc. 28, 97-109], whereby the additional information on interdependence of both measured data and climate changes can be incorporated into the model in the form of covariance matrices. Three main episodes can be distinguished in the last 250 years: a warm period between 1790 and 1830, a slightly colder period in 1940-1960, and a general warming with the average rates of 0.01-0.03 K/year since then. The geographical distribution of the recent warming rate may indicate an impact of human activities. The verification of the GST assessment was accomplished by the independent past climate reconstructions gained by the use of historical sources and instrumental records.

  19. Snow Cover Maps from MODIS Images at 250 m Resolution, Part 2: Validation

    Directory of Open Access Journals (Sweden)

    Marc Zebisch

    2013-03-01

    Full Text Available The performance of a new algorithm for binary snow cover monitoring based on Moderate Resolution Imaging Spectroradiometer (MODIS satellite images at 250 m resolution is validated using snow cover maps (SCA based on Landsat 7 ETM+ images and in situ snow depth measurements from ground stations in selected test sites in Central Europe. The advantages of the proposed algorithm are the improved ground resolution of 250 m and the near real-time availability with respect to the 500 m standard National Aeronautics and Space Administration (NASA MODIS snow products (MOD10 and MYD10. It allows a more accurate snow cover monitoring at a local scale, especially in mountainous areas characterized by large landscape heterogeneity. The near real-time delivery makes the product valuable as input for hydrological models, e.g., for flood forecast. A comparison to sixteen snow cover maps derived from Landsat ETM/ETM+ showed an overall accuracy of 88.1%, which increases to 93.6% in areas outside of forests. A comparison of the SCA derived from the proposed algorithm with standard MODIS products, MYD10 and MOD10, indicates an agreement of around 85.4% with major discrepancies in forested areas. The validation of MODIS snow cover maps with 148 in situ snow depth measurements shows an accuracy ranging from 94% to around 82%, where the lowest accuracies is found in very rugged terrain restricted to in situ stations along north facing slopes, which lie in shadow in winter during the early morning acquisition.

  20. Liposomes for cardiovascular targeting.

    Science.gov (United States)

    Levchenko, Tatyana S; Hartner, William C; Torchilin, Vladimir P

    2012-04-01

    Liposome-based pharmaceuticals used within the cardiovascular system are reviewed in this article. The delivery of diagnostic and therapeutic agents by plain liposomes and liposomes with surface-attached targeting antibodies or polyethylene glycol to prolong their circulation time and accumulation at vascular injuries, ischemic zones or sites of thrombi are also discussed. An overview of the advantages and disadvantages of liposome-mediated in vitro, ex vivo and in vivo targeting is presented, including discussion of the targeting of liposomes to pathological sites on the blood vessel wall and a description of liposomes that can be internalized by endothelial cells. Diagnostic liposomes used to target myocardial infarction and the relative importance of liposome size, targetability of immunoliposomes and prolonged circulation time on the efficiency of sealing hypoxia-induced plasma membrane damage to cardiocytes are discussed as a promising approach for therapy. The progress in the use of targeted liposomal plasmids for the transfection of hypoxic cardiomyocytes and myocardium is presented. Stent-mediated liposomal-based drug delivery is also reviewed briefly. PMID:22834079

  1. Radar target detection simulation

    Directory of Open Access Journals (Sweden)

    Tarig Ibrahim Osman

    2014-12-01

    Full Text Available Standard radar detection process requires that the sensor output is compared to a predetermined threshold. The threshold is selected based on a-priori knowledge available and/or certain assumptions. However, any knowledge and/or assumptions become in adequate due to the presence of multiple targets with varying signal return and usually non stationary background. Thus, any predetermined threshold may result in either increased false alarm rate or increased track loss. Even approaches where the threshold is adaptively varied will not perform well in situations when the signal return from the target of interest is too low compared to the average level of the background .Track-before-detect techniques eliminate the need for a detection threshold and provide detecting and tracking targets with lower signal-to-noise ratios than standard methods. However, although trackbefore-detect techniques eliminate the need for detection threshold at sensor's signal processing stage, they often use tuning thresholds at the output of the filtering stage .This paper presents a computerized simulation model for target detection process. Moreover, the proposed model method is based on the target motion models, the output of the detection process can easily be employed for maneuvering target tracking.

  2. An ISOLDE target unit

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    A good dozen different targets are available for ISOLDE, made of different materials and equipped with different kinds of ion-sources, according to the needs of the experiments. Each separator (GPS: general purpose; HRS: high resolution) has its own target. Because of the high radiation levels, robots effect the target changes, about 80 times per year. In the standard unit shown in picture _01, the target is the cylindrical object in the front. It contains uranium-carbide kept at a temperature of 2200 deg C, necessary for the isotopes to be able to escape. At either end, one sees the heater current leads, carrying 700 A. The Booster beam, some 3E13 protons per pulse, enters the target from left. The evaporated isotope atoms enter a hot-plasma ion source (the black object behind the target). The whole unit sits at 60 kV potential (pulsed in synchronism with the arrival of the Booster beam) which accelerates the ions (away from the viewer) towards one of the 2 separators.

  3. VIABILITAS DAN STABILITAS Lactobacillus Plantarum Mut7 FNCC 250 YANG DISUPLEMENTASIKAN DALAM SARI BUAH PEPAYA-NANAS SELAMA PENYIMPANAN [Viability and Stability of Lactobacillus Plantarum Mut 7 FNCC 250 Suplemented in Papaya-Pineapple Juice During Storage

    Directory of Open Access Journals (Sweden)

    Sri Hartati1

    2003-08-01

    Full Text Available Lactobacillus plantarum Mut7 FNCC 250 is an indigenous bacterium isolated from fermented food (“gatot” and a potential agent to reduce cholesterol. Study the on aplication of the bacterium as probiotic agent to food stuff is needed. The purpose of the study was to prepare formula of papaya-pineapple juice as probiotic carrier and to study the viability and capability of Lactobacillus plantarum Mut7 FNCC 250 to assimilate cholesterol during three months storage. Fruits juice was prepared with different formula and organoleptically tested. Selected juice formula was supplemented with Lactobacillus plantarum Mut7 FNCC 250 and stored in cool room (4-5 oC. During three month storage, the value of pH the product, cell viability and ability to assimilate cholesterol were evaluated. The result indicated that acceptable formula was papaya juice added with 25 % pineapple. Viability of Lactobacillus plantarum Mut7 FNCC 250 supplemented in papaya- pineapple juice was stable (decrease of < 1 log cycle, while the pH of the juice decreased after 3 month storage. The ability of Lactobacillus plantarum Mut7 FNCC 250 to assimilate cholesterol was stable within 2 months storage, but decreased after 3 months.

  4. Survey of potential markets for devices using Californium-252

    International Nuclear Information System (INIS)

    Potential applications for devices or systems containing 252Cf in the years from 1975 to 1980 are estimated. The estimated number of devices and associated business value were derived from a survey of 46 industrial, educational and governmental organizations conducted from Jan. to May, 1975. Applications for devices and systems based on 252Cf are expected to increase by a factor of 7 in the 6-y period from 1975 to 1980. The annual business value of 252Cf devices should increase from 1.5 million dollars in 1975 to 10.8 million dollars in 1980. The potential European market should be several times as large as the US market, based on actual sales of 252Cf, which have been two to four times greater in Europe than in the US

  5. Automated absolute activation analysis with californium-252 sources

    Energy Technology Data Exchange (ETDEWEB)

    MacMurdo, K.W.; Bowman, W.W.

    1978-09-01

    A 100-mg /sup 252/Cf neutron activation analysis facility is used routinely at the Savannah River Laboratory for multielement analysis of many solid and liquid samples. An absolute analysis technique converts counting data directly to elemental concentration without the use of classical comparative standards and flux monitors. With the totally automated pneumatic sample transfer system, cyclic irradiation-decay-count regimes can be pre-selected for up to 40 samples, and samples can be analyzed with the facility unattended. An automatic data control system starts and stops a high-resolution gamma-ray spectrometer and/or a delayed-neutron detector; the system also stores data and controls output modes. Gamma ray data are reduced by three main programs in the IBM 360/195 computer: the 4096-channel spectrum and pertinent experimental timing, counting, and sample data are stored on magnetic tape; the spectrum is then reduced to a list of significant photopeak energies, integrated areas, and their associated statistical errors; and the third program assigns gamma ray photopeaks to the appropriate neutron activation product(s) by comparing photopeak energies to tabulated gamma ray energies. Photopeak areas are then converted to elemental concentration by using experimental timing and sample data, calculated elemental neutron capture rates, absolute detector efficiencies, and absolute spectroscopic decay data. Calculational procedures have been developed so that fissile material can be analyzed by cyclic neutron activation and delayed-neutron counting procedures. These calculations are based on a 6 half-life group model of delayed neutron emission; calculations include corrections for delayed neutron interference from /sup 17/O. Detection sensitivities of < or = 400 ppB for natural uranium and 8 ppB (< or = 0.5 (nCi/g)) for /sup 239/Pu were demonstrated with 15-g samples at a throughput of up to 140 per day. Over 40 elements can be detected at the sub-ppM level.

  6. Californium-252 neutron activation facility at the Savannah River Laboratory

    International Nuclear Information System (INIS)

    A neutron irradiation facility has been established to develop new analytical methods and for the support of research programs. A major component of this facility is a 252Cf source which provides both fission spectrum and thermal neutrons. (U.S.)

  7. The Sinuous Target

    Energy Technology Data Exchange (ETDEWEB)

    Zwaska, R. [Fermilab

    2015-06-01

    We report on the concept for a target material comprised of a multitude of interlaced wires of small dimension. This target material concept is primarily directed at high-power neutrino targets where the thermal shock is large due to small beam sizes and short durations; it also has applications to other high-power targets, particularly where the energy deposition is great or a high surface area is preferred. This approach ameliorates the problem of thermal shock by engineering a material with high strength on the micro-scale, but a very low modulus of elasticity on the meso-scale. The low modulus of elasticity is achieved by constructing the material of spring-like wire segments much smaller than the beam dimension. The intrinsic bends of the wires will allow them to absorb the strain of thermal shock with minimal stress. Furthermore, the interlaced nature of the wires provides containment of any segment that might become loose. We will discuss the progress on studies of analogue materials and fabrication techniques for sinuous target materials.

  8. Production Target Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dale, Gregory E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Olivas, Eric Richard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-07-28

    The Northstar 99Mo production target, a cylindrical length of 100Mo rod, has evolved considerably since its first conception.  The cylinder was very early sliced into disks to increase the heat transfer area, first to 1 mm thick disks then to the current 0.5 mm thick.  The coolant was changed early in the target development from water to helium to eliminate corrosion and dissolution.  The diameter has increased from initially 6 mm to 12 mm, the current diameter of the test target now at ANL, to nominally 28 mm (26-30.6 mm, depending upon optimal beam spot size and shape).  The length has also changed to improve the production to cost ratio, so now the target is nominally 41 mm long (excluding coolant gaps between disks), and irradiated on both ends.  This report summarizes the current status of the plant target design.

  9. Inflation Forecast Targeting: Implementing and Monitoring Inflation Targets

    OpenAIRE

    Lars E.O. Svensson

    1996-01-01

    Inflation targeting is shown to imply inflation forecast targeting: the central bank's inflation forecast becomes an intermediate target. Inflation forecast targeting simplifies both implementing and monitoring of monetary policy. The inflation forecast is actually an ideal intermediate target: it is most correlated with the goal, easier to control than the goal, more observable than the goal, and very transparent. Money growth targeting generally leads to higher inflation variability than in...

  10. 250t/50t/10t精确吊装用桥式起重机的设计%Design of 250 t/50 t/10 t overhead travelling crane for accurate hoisting

    Institute of Scientific and Technical Information of China (English)

    王海涛; 潘彦宏

    2012-01-01

    介绍了安装于印度尼西亚某水电站厂房内的精确吊装用250 t/50 t/10 t桥式起重机性能、控制系统特点及其设计思路,指出了变频器选配要点.%This paper describes the performance, control system characteristics and design ideas of accurate hoisting 250t/50t/10t overhead travelling crane installed in the plant of the hydropower station in Indonesia, The key points for selecting and matching of frequency converters are also put forward in the paper.

  11. Influence of electroporation on immunogenicity of the DNA vaccine pVAX-tG250FcGB%电穿孔技术对DNA疫苗pVAX-tG250FcGB免疫效果的影响

    Institute of Scientific and Technical Information of China (English)

    肖毅; 于继云; 高昆; 杨勇; 阎瑾琦; 张亮; 王宇; 徐元基; 田仁礼; 杜芝燕

    2013-01-01

    Objective To investigate the influence of electroporation on the immunogenicity of the DNA vaccine pVAX-tG250FcGB. Methods The DNA vaccine pVAX-tG250FcGB was constructed by inserting the coding gene of tG250 fusion genes into the expression vector pVAX. The DNA vaccine was delivered in BALB/c mouse by electroporation or intramuscular injection, and the induced antigen specific immune responses were compared. Results The vaccine delivered by electroporation and intramuscular injection both induced immune responses in BALB/c mouse, but electroporation produced an obviously stronger effect than intramuscular injection. Conclusion Electroporation-mediated DNA vaccine delivery can produce strong immune response in mice and is an effective means for studying the immunogenic effect of DNA vaccine pVAX-tG250FcGB.%目的:探讨应用电穿孔技术对DNA疫苗pVAX-tG250FcGB免疫效果的影响。方法构建肾癌DNA疫苗pVAX-tG250FcGB,通过体内电穿孔技术或普通肌肉注射途径,将DNA疫苗导入到BALB/c小鼠体内,探讨电穿孔免疫途径诱导抗原特异性免疫应答的效果。结果电穿孔技术或普通肌肉注射均能在小鼠体内诱导出抗原特异性的体液免疫应答和细胞免疫应答,电穿孔技术的免疫效果明显优于普通肌肉注射途径。结论电穿孔技术介导的DNA疫苗pVAX-tG250FcGB免疫具有较强的诱导免疫应答的能力,是研究DNA疫苗pVAX-tG250FcGB免疫效果的一种有效途径。

  12. Side effects of propiconazole (tilt 250 EC(TM)) on non-target soil fungi in a field trial compared with natural stress effects.

    Science.gov (United States)

    Elmholt, S

    1991-12-01

    The present study was performed as a dose-response field experiment using a trade marked formulation of the ergosterol biosynthesis inhibiting fungicide, propiconazole, applied at the recommended and ten times the recommended application rates. The soil dilution plate method was used to isolate fungi from 0-1 and 1-2 cm soil depth. Soil samples were taken 10 times during the period from May 22 to August 11, 1986. The numbers of yeasts and filamentous fungi were enumerated, the latter includingCladosporium andPenicillium, which were also enumerated separately. The fluctuations in fungal occurrence due to the propiconazole treatment were smaller than seasonal fluctuations, these most likely being caused by variations in the soil matric potential and by soil invasion of phyllosphere fungi. Fungicide treatment had significant inhibitory effects on the filamentous fungi, especially on theCladosporium, whereas no significant effects were found on the yeasts and onPenicillium spp. From an ecotoxicological point of view, it is important that the effects were considerably delayed, with respect to the time of fungicide application. PMID:24194329

  13. Phoenix Color Targets

    Science.gov (United States)

    2008-01-01

    These images of three Phoenix color targets were taken on sols 1 and 2 by the Surface Stereo Imager (SSI) on board the Phoenix lander. The bottom target was imaged in approximate color (SSI's red, green, and blue filters: 600, 530, and 480 nanometers), while the others were imaged with an infrared filter (750 nanometers). All of them will be imaged many times over the mission to monitor the color calibration of the camera. The two at the top show grains 2 to 3 millimeters in size that were likely lifted to the Phoenix deck during landing. Each of the large color chips on each target contains a strong magnet to protect the interior material from Mars' magnetic dust. The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  14. Targeted Phototherapy (newer phototherapy

    Directory of Open Access Journals (Sweden)

    Zonunsanga

    2015-04-01

    Full Text Available Conventional phototherapy uses a whole body cabinet or body part machine such as hand, foot or scalp machines. They have many disadvantages due to which new phototherapy technique was then developed to overcome this situation. This new technique is called targeted phototherapy which includes excimer laser, intense pulse light system (IPL, photodynamic therapy and ultraviolet (UV light source with a sophisticated delivery system which is easy to be operated by hands. The mechanisms of action of targeted phototherapy systems are similar to those in conventional UVB/UVA therapy. They have many advantages like less chances of side effects, avoidance of exposure of unnecessary sites, faster response, shortening of the duration of treatments. But they have disadvantages like high costs and inability to use for extensive areas. This review article discusses targeted phototherapy in considerable to the mechanism of actions and advantages and disadvantages in comparison to the conventional phototherapy.

  15. Setting reference targets

    International Nuclear Information System (INIS)

    Reference Targets are used to represent virtual quantities like the magnetic axis of a magnet or the definition of a coordinate system. To explain the function of reference targets in the sequence of the alignment process, this paper will first briefly discuss the geometry of the trajectory design space and of the surveying space, then continue with an overview of a typical alignment process. This is followed by a discussion on magnet fiducialization. While the magnetic measurement methods to determine the magnetic centerline are only listed (they will be discussed in detail in a subsequent talk), emphasis is given to the optical/mechanical methods and to the task of transferring the centerline position to reference targets

  16. Modelling Recycling Targets

    DEFF Research Database (Denmark)

    hill, amanda; Leinikka Dall, Ole; Andersen, Frits Møller

    2014-01-01

    Within the European Union (EU) a paradigm shift is currently occurring in the waste sector, where EU waste directives and national waste strategies are placing emphasis on resource efficiency and recycling targets. The most recent Danish resource strategy calculates a national recycling rate of 22......% for household waste, and sets an ambitious goal of a 50% recycling rate by 2020. This study integrates the recycling target into the FRIDA model to project how much waste and from which streams should be diverted from incineration to recycling in order to achieve the target. Furthermore, it discusses...... how the existing technological, organizational and legislative frameworks may affect recycling activities. The results of the analysis show that with current best practice recycling rates, the 50% recycling rate cannot be reached without recycling of household biowaste. It also shows that all Danish...

  17. Indirectly driven targets for inertial confinement fusion

    International Nuclear Information System (INIS)

    The physics of indirectly driven targets for inertial confinement fusion - so called hohlraum targets - is investigated. Scaling relations for radiation heat waves in high-Z and low-Z materials are derived from one-dimensional multigroup simulation. A two-temperature model is developed for radiation cavities including fusion capsules. The efficiency of X-ray transfer to the capsule by multiple absorption and re-emission inside the cavity is obtained as a function of cavity areas and materials. Using gold for the cavity wall and carbon for the capsule ablator, transfer efficiencies between 50% and 33% are obtained for area ratios between 5 and 10, respectively. Also, the hydrodynamic efficiency of X-ray driven capsule implosion and the dependence of the implosion velocity on the hohlraum temperature are given analytically, derived from the rocket model. With carbon ablators, hydroefficiencies of up to 20% can be achieved. Under optimal conditions, an implosion velocity of 3 x 107 cm/s is reached with a temperature of about 210 eV of the capsule ablator and about 250 eV of the cavity wall. Assuming 70-90% conversion efficiency of beam energy into X-rays (not analysed in this paper), overall coupling efficiencies in the range of 5-10% seem to be possible. One-dimensional simulations of full reactor size targets (10MJ driver pulses) are presented. The model results compare well with the simulations. Limit in scaling down to smaller systems are discussed; the scaling relation for the required enhancement of implosion velocity and hohlraum temperature is derived. (author). 21 refs, 14 figs, 1 tab

  18. AA antiproton production target

    CERN Multimedia

    1979-01-01

    The first version of the antiproton production target was a tungsten rod, 11 cm long (actually a row of 11 rods, each 1 cm long) and 3 mm in diameter. The rod was embedded in graphite, pressure-seated into an outer casing made of stainless steel. The casing had fins for forced-air cooling. In this picture, the 26 GeV high-intensity beam from the PS enters from the right, where a scintillator screen, with circles every 5 mm in radius, permits precise aim at the target centre. See also 7903034 and 7905094.

  19. Targeting peroxiredoxins against leukemia.

    Science.gov (United States)

    Liu, Chuan-Xu; Zhou, Hu-Chen; Yin, Qian-Qian; Wu, Ying-Li; Chen, Guo-Qiang

    2013-01-15

    Peroxiredoxins (Prx), a family of small non-seleno peroxidases, are important regulators for cellular reactive oxygen species (ROS), which contribute to many signaling pathways and pathogenesis of diseases. Targeting redox homeostasis is being developed as a promising therapeutic strategy for many diseases such as cancers. This mini-review attempts to focus on our recent discoveries on adenanthin as the first natural molecule to specifically target the resolving cysteines of Prx I and Prx II and thus inhibit their peroxidase activities, and its role in differentiation induction in vitro and in vivo of acute myeloid leukemic cells.

  20. Corrosion mechanisms of the AlFeNi aluminium alloy by water up to 250 deg

    International Nuclear Information System (INIS)

    Full text of publication follows: The AlFeNi aluminium alloy (1%Fe, 1%Ni, 1%Mg) will be used as nuclear fuel cladding in the Jules Horowitz research reactor. A better understanding of the corrosion mechanisms of this alloy in water is necessary to predict correctly the corrosion rate and the oxide thickness on the fuel plates. Corrosion tests in water at an average pH of 6.9 were hence performed on this alloy in static conditions at 70, 165 and 250 C, and in dynamic conditions at 70 C. The hydroxide film obtained on the samples corroded in autoclaves or at the slow flow rates is composed of two main layers: a dense and amorphous inner layer which grows by anionic diffusion and a porous crystalline outer layer which develops by cationic diffusion followed by a dissolution-precipitation process. The ratio of the amorphous oxide thickness to the corroded metal thickness decreases with corrosion time, thus indicating an increasing density of the amorphous oxide. Consequently, the diffusion through the inner oxide layer decreases drastically with corrosion time. The inner oxide thickness evolution is well described by a cationic diffusion model, with an apparent cationic diffusion coefficient decreasing exponentially with time. A comparison of the corrosion scales obtained in water and in vapour at 250 C showed that in the vapour, the outer precipitation oxide layer does not develop, and the inner oxide thickness is much lower. These results suggest that the anionic diffusion which controls the corrosion rate at the metal interface is coupled with the cationic diffusion and dissolution rate. The hydraulic conditions play therefore a dominant role in the corrosion rate. During dynamic experiments in once-through reactors at 70 C, the cationic release in the leaching water was measured at different times. Two leaching flow rates were used: 100 and 200 ml/h. After the first 3 hours, the aluminium and magnesium release follow a parabolic evolution, characteristic of a

  1. Crop Dominance Mapping with IRS-P6 and MODIS 250-m Time Series Data

    Directory of Open Access Journals (Sweden)

    Murali Krishna Gumma

    2014-04-01

    Full Text Available This paper describes an approach to accurately separate out and quantify crop dominance areas in the major command area in the Krishna River Basin. Classification was performed using IRS-P6 (Indian Remote Sensing Satellite, series P6 and MODIS eight-day time series remote sensing images with a spatial resolution of 23.6 m, 250 m for the year 2005. Temporal variations in the NDVI (Normalized Difference Vegetation Index pattern obtained in crop dominance classes enables a demarcation between long duration crops and short duration crops. The NDVI pattern was found to be more consistent in long duration crops than in short duration crops due to the continuity of the water supply. Surface water availability, on the other hand, was dependent on canal water release, which affected the time of crop sowing and growth stages, which was, in turn, reflected in the NDVI pattern. The identified crop-wise classes were tested and verified using ground-truth data and state-level census data. The accuracy assessment was performed based on ground-truth data through the error matrix method, with accuracies from 67% to 100% for individual crop dominance classes, with an overall accuracy of 79% for all classes. The derived major crop land areas were highly correlated with the sub-national statistics with R2 values of 87% at the mandal (sub-district level for 2005–2006. These results suggest that the methods, approaches, algorithms and datasets used in this study are ideal for rapid, accurate and large-scale mapping of paddy rice, as well as for generating their statistics over large areas. This study demonstrates that IRS-P6 23.6-m one-time data fusion with MODIS 250-m time series data is very useful for identifying crop type, the source of irrigation water and, in the case of surface water irrigation, the way in which it is applied. The results from this study have assisted in improving surface water and groundwater irrigated areas of the command area and also

  2. Sodium trimetaphosphate enhances the effect of 250 p.p.m. fluoride toothpaste against enamel demineralization in vitro.

    Science.gov (United States)

    Missel, Emilene M C; Cunha, Robson F; Vieira, Ana E M; Cruz, Nathália V S; Castilho, Flavia C N; Delbem, Alberto C B

    2016-08-01

    This in vitro study investigated the effect of sodium trimetaphosphate (TMP), added to toothpaste containing 250 p.p.m. fluoride, on enamel demineralization. Bovine enamel blocks (n = 96) were subjected to five pH cycles over a 7-d period and treatment with suspensions of toothpastes containing 0, 250, 500, and 1,100 p.p.m. fluoride (as sodium fluoride), as well as with 250 p.p.m. fluoride containing TMP at 0.25, 0.5, 1.0, and 3.0%. Treatment with toothpaste suspensions was performed under agitation twice a day, for 1 min. Surface and cross-sectional hardness, and fluoride firmly bound to enamel, were quantified. Data were subjected to one-way anova, followed by Tukey's test. Low-fluoride toothpastes containing TMP at 0.25-1.0% resulted in enamel mineral loss similar to that seen for the toothpaste containing 1,100 p.p.m. fluoride. Also, the addition of TMP to the toothpaste containing 250 p.p.m. fluoride promoted enamel fluoride concentrations similar to those obtained for the 500 p.p.m. fluoride group. The toothpaste containing 250 p.p.m. fluoride and 0.25% TMP led to the lowest mineral loss among all groups. It was concluded that the addition of as little as 0.25% TMP to a toothpaste containing 250 p.p.m. fluoride can reduce enamel demineralization to levels similar to those seen for a conventional toothpaste containing 1,100 p.p.m. fluoride, in vitro. PMID:27198971

  3. Major Targets for 2010

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ This year, the main targets we have set for economic and social development are: increasing GDP by approximately 8 percent, creating jobs for more than 9 million people, keeping the urban registered unemployment rate no higher than 4.6 percent, holding the rise in consumer prices to around 3 percent, and improving the balance of payments.

  4. Target chambers for gammashpere

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, M.P.; Falout, J.W.; Nardi, B.G. [and others

    1995-08-01

    One of our responsibilities for Gammasphere, was designing and constructing two target chambers and associated beamlines to be used with the spectrometer. The first chamber was used with the early implementation phase of Gammasphere, and consisted of two spun-Al hemispheres welded together giving a wall thickness of 0.063 inches and a diameter of 12 inches.

  5. Enhanced target factor analysis.

    Science.gov (United States)

    Rostami, Akram; Abdollahi, Hamid; Maeder, Marcel

    2016-03-10

    Target testing or target factor analysis, TFA, is a well-established soft analysis method. TFA answers the question whether an independent target test vector measured at the same wavelengths as the collection of spectra in a data matrix can be excluded as the spectrum of one of the components in the system under investigation. Essentially, TFA cannot positively prove that a particular test spectrum is the true spectrum of one of the components, it can, only reject a spectrum. However, TFA will not reject, or in other words TFA will accept, many spectra which cannot be component spectra. Enhanced Target Factor Analysis, ETFA addresses the above problem. Compared with traditional TFA, ETFA results in a significantly narrower range of positive results, i.e. the chance of a false positive test result is dramatically reduced. ETFA is based on feasibility testing as described in Refs. [16-19]. The method has been tested and validated with computer generated and real data sets. PMID:26893084

  6. Cancer immunotherapy targeting neoantigens.

    Science.gov (United States)

    Lu, Yong-Chen; Robbins, Paul F

    2016-02-01

    Neoantigens are antigens encoded by tumor-specific mutated genes. Studies in the past few years have suggested a key role for neoantigens in cancer immunotherapy. Here we review the discoveries of neoantigens in the past two decades and the current advances in neoantigen identification. We also discuss the potential benefits and obstacles to the development of effective cancer immunotherapies targeting neoantigens.

  7. ISOLDE back on target

    CERN Multimedia

    Anaïs Schaeffer

    2014-01-01

    Today, Friday 1 August, the ISOLDE installation, supplied by the beams of the PS Booster, restarted its physics programme. After a shutdown of almost a year and a half, there was a real buzz in the air as the first beam of protons hit the target of the first post-LS1 ISOLDE experiment.   One of the new target-handling robots installed by ISOLDE during LS1. Many improvements have been made to the ISOLDE installation during LS1. One of the main projects was the installation of new robots for handling the targets (see photo 1). “Our targets are bombarded by protons from the PS Booster’s beams and become very radioactive,” explains Maria Jose Garcia Borge, spokesperson for the ISOLDE collaboration. “They therefore need to be handled carefully, which is where the robots come in. The robots we had until now were already over 20 years old and were starting to suffer from the effects of radiation. So LS1 was a perfect opportunity to replace them with more moder...

  8. Paediatric Tuberculosis at a Referral Hospital in Istanbul: Analysis of 250 Cases.

    Science.gov (United States)

    Turel, Ozden; Kazanci, Selcen; Gonen, Ismail; Aydogmus, Cigdem; Karaoglan, Emel; Siraneci, Rengin

    2016-01-01

    Background. Tuberculosis (TB) still remains a growing public health problem globally. TB in children is often diagnosed clinically. Methods. We conducted a retrospective chart review of children with TB from November 2004 through December 2010 to determine the appropriateness of using contact history and diagnostic testing. Results. A total of 250 children with TB were identified. One hundred and sixty-two children had only pulmonary disease while 39 had features of both extrapulmonary and pulmonary TB. Mean age was 7.8 years. Thirty-six patients had known contacts. The index case/cases were first-degree relatives in 75%. Sixteen patients who were symptomless were yielded by contact investigation of newly identified TB cases. Tuberculin skin test positivity was 53.3%. Acid-fast bacilli smear positivity was 13.1%, and culture positivity was 18.7%. Twenty-six patients had histopathology of nonrespiratory specimens (lymph nodes and other tissues) showing granulomatous inflammation and caseous necrosis consistent with TB. Conclusions. Presence of contact history directed us to search for TB in children with nonspecific symptoms even if physical examinations were normal. Some children who were close contacts to TB cases were identified to have TB before development of symptoms.

  9. Neanderthal use of fish, mammals, birds, starchy plants and wood 125-250,000 years ago.

    Directory of Open Access Journals (Sweden)

    Bruce L Hardy

    Full Text Available Neanderthals are most often portrayed as big game hunters who derived the vast majority of their diet from large terrestrial herbivores while birds, fish and plants are seen as relatively unimportant or beyond the capabilities of Neanderthals. Although evidence for exploitation of other resources (small mammals, birds, fish, shellfish, and plants has been found at certain Neanderthal sites, these are typically dismissed as unusual exceptions. The general view suggests that Neanderthal diet may broaden with time, but that this only occurs sometime after 50,000 years ago. We present evidence, in the form of lithic residue and use-wear analyses, for an example of a broad-based subsistence for Neanderthals at the site of Payre, Ardèche, France (beginning of MIS 5/end of MIS 6 to beginning of MIS 7/end of MIS 8; approximately 125-250,000 years ago. In addition to large terrestrial herbivores, Neanderthals at Payre also exploited starchy plants, birds, and fish. These results demonstrate a varied subsistence already in place with early Neanderthals and suggest that our ideas of Neanderthal subsistence are biased by our dependence on the zooarchaeological record and a deep-seated intellectual emphasis on big game hunting.

  10. Magnetic fields and beam optics studies of a 250 MeV superconducting proton radiotherapy cyclotron

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jong-Won [Research Institute and Hospital, National Cancer Center, 809 Madu-dong, Koyang, Kyonggi (Korea, Republic of)], E-mail: jwkim@ncc.re.kr

    2007-11-21

    A 250 MeV superconducting cyclotron for the proton radiation therapy was designed at the Michigan State University (MSU) for use at the Paul Scherrer Institut. This work was based on the conceptual design carried out at the MSU in 1994. The previous design was refined to finalize the magnet configuration and to optimally arrange cyclotron elements for the actual construction. The spiral angle of the pole was reduced, the new hill-edges and valley shims being introduced. The magnetic fields were highly isochronized using a least square fitting routine involving a schematic shimming scheme. The resulting reference field was adequate for the elaborate study of beam optics. The optics simulation predicted that extraction efficiency of above 80% was achievable for a beam with the initial phase width of 20{sup o}. The vertical deflector was investigated located in the central region to control the beam intensity with tracking of beam phase spaces. Some measurement results for the constructed cyclotron were found in a good agreement with those of the optics study.

  11. Integrated tests of a high speed VXS switch card and 250 MSPS flash ADCs

    Energy Technology Data Exchange (ETDEWEB)

    H. Dong, C. Cuevas, D. Curry, E. Jastrzembski, F. Barbosa, J. Wilson, M. Taylor, B. Raydo

    2008-01-01

    High trigger rate nuclear physics experiments proposed for the 12 GeV upgrade at the Thomas Jefferson National Accelerator Facility create a need for new high speed digital systems for energy summing. Signals from electronic detectors will be captured with the Jefferson Lab FADC module, which collects and processes data from 16 charged particle sensors with 10 or 12 bit resolution at 250 MHz sample rate. Up to sixteen FADC modules transfer energy information to a central energy summing module for each readout crate. The sums from the crates are combined to form a global energy sum that is used to trigger data readout for all modules. The Energy Sum module and FADC modules have been designed using the VITA-41 VME64 switched serial (VXS) standard. The VITA- 41 standard defines payload and switch slot module functions, and offers an elegant engineered solution for Multi-Gigabit serial transmission on a standard VITA-41 backplane. The Jefferson Lab Energy Sum module receives data serially at a rate of up to 6 Giga-bits per second from the FADC modules. Both FADC and Energy Sum modules have been designed and assembled and this paper describes the integrated tests using both high speed modules in unison

  12. MUSE-ings on AM1354-250: Collisions, Shocks and Rings

    CERN Document Server

    Conn, Blair C; Smith, Rory; Candlish, Graeme N

    2015-01-01

    We present MUSE observations of AM1354-250, confirming its status as a collisional ring galaxy which has recently undergone an interaction, creating its distinctive shape. We analyse the stellar and gaseous emission throughout the galaxy finding direct evidence that the gaseous ring is expanding with a velocity of $\\sim$70km.s$^{-1}$ and that star formation is occurring primarily in HII regions associated with the ring. This star formation activity is likely triggered by the interaction. We find evidence for several excitation mechanisms in the gas, including emission consistent with shocked gas in the expanding ring and a region of LINER-like emission in the central core of the galaxy. Evidence of kinematic disturbance in both the stars and gas, possibly also triggered by the interaction, can be seen in all of the velocity maps. The ring galaxy retains weak spiral structure, strongly suggesting the progenitor galaxy was a massive spiral prior to the collision with its companion an estimated $140 \\pm 12$ Myr ...

  13. MUSE-ings on AM1354-250: Collisions, Shocks, and Rings

    Science.gov (United States)

    Conn, Blair C.; Fogarty, L. M. R.; Smith, Rory; Candlish, Graeme N.

    2016-03-01

    We present Multi Unit Spectroscopic Explorer observations of AM1354-250, confirming its status as a collisional ring galaxy that has recently undergone an interaction, creating its distinctive shape. We analyze the stellar and gaseous emission throughout the galaxy finding direct evidence that the gaseous ring is expanding with a velocity of ˜70 km s-1 and that star formation is occurring primarily in H ii regions associated with the ring. This star formation activity is likely triggered by this interaction. We find evidence for several excitation mechanisms in the gas, including emission consistent with shocked gas in the expanding ring and a region of LINER-like emission in the central core of the galaxy. Evidence of kinematic disturbance in both the stars and gas, possibly also triggered by the interaction, can be seen in all of the velocity maps. The ring galaxy retains a weak spiral structure, strongly suggesting the progenitor galaxy was a massive spiral prior to the collision with its companion an estimated 140 ± 12 Myr ago.

  14. [Jonathan Swift's asylum in Dublin--Ireland's introduction to institutional psychiatry 250 years ago].

    Science.gov (United States)

    Reuber, M

    1995-09-01

    250 years ago, the satirical writer and clergyman Jonathan Swift from Dublin (1667-1745) founded the first Irish lunatic asylum. Rejecting the theories put forward by the English philosopher Thomas Hobbes and the doctor Thomas Willis, he was influenced by the ideas of the Scottish doctor and the "enlightened" thinker John Locke. Swift's St. Patrick's Hospital did not, however, realise a new philosophical concept: architecture and therapeutic approach of the new institution were clearly modelled on the much older Hospital of St. Mary of Bethlehem ( = Bedlam). Despite its conservative conceptual basis, the first institution dedicated to the mentally ill and intellectually subnormal in Ireland became a starting point for the apparantly unstoppable expansion of the, at one time, most comprehensive asylum system in the world. After Swift's Hospital had been enlarged twice at the tax-payers' expense (1778, 1793), the administration decided to relieve the institution by erecting the Richmond Asylum (1810), the first public asylum in Ireland. When this establishment also became overcrowded, in 1817, legislation was passed which led to the establishment of the oldest system of public asylums in Europe.

  15. 1:250,000-scale Hydrologic Units of the United States

    Science.gov (United States)

    Steeves, Peter; Nebert, Douglas

    1994-01-01

    The Geographic Information Retrieval and Analysis System (GIRAS) was developed in the mid 70s to put into digital form a numberof data layers which were of interest to the USGS. One of these data layers was the Hydrologic Units. The map is based on the Hydrologic Unit Maps published by the U.S. Geological Survey Office of Water Data Coordination, together with the list descriptions and name of region, subregion, accounting units, and cataloging unit. The hydrologic units are encoded with an eight-digit number that indicates the hydrologic region (first two digits), hydrologic subregion (second two digits), accounting unit (third two digits), and cataloging unit (fourth two digits). The data produced by GIRAS was originally collected at a scale of 1:250K. Some areas, notably major cities in the west, were recompiled at a scale of 1:100K. In order to join the data together and use the data in a geographic information system (GIS) the data were processed in the ARC/INFO GUS software package. Within the GIS, the data were edgematched and the neatline boundaries between maps were removed to create a single data set for the conterminous

  16. Study on Laser Transformation Hardening of HT250 by High Speed Axis Flow CO2 Laser

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    In this article, laser transformation hardening of HT250 material by high speed axis flow CO2 laser was investigated for first time in China. Appropriate laser hardening parameters, such as laser energy power P(W), laser scanning rate V(m/min),were optimized through a number of experiments. The effect of the mentioned parameters on the hardened zone, including its case depth, microhardness distributions etc., were analyzed. Through the factual experiments, it is proved that axial flow CO2 laser, which commonly outputs low mode laser beam, can also treat materials as long as the treating parameters used are rational. During the experiments, the surface qualities of some specimens treated by some parameters were found to be enhanced, which does not coincide with the former results. Furthermore in the article, the abnormal phenomenon observed in the experiments is discussed. According to the experimental results, the relationship between laser power density q and scanning rate V is shown in a curve and the corresponding formulation, which have been proved to be valuable for choosing the parameters of laser transformation hardening by axial flow CO2 lasers, was also given.

  17. A star forming ring around Kappa Ori 250 pc from the Sun

    CERN Document Server

    Pillitteri, I; Megeath, S T

    2016-01-01

    X-rays are a powerful probe of activity in early stages of star formation. They allow us to identify young stars even after they have lost the IR signatures of circumstellar disks and provide constraints on their distance. Here we report on XMM-Newton observations which detect 121 young stellar objects (YSOs) in two fields between L1641S and $\\kappa$ Ori. These observations extend the Survey of Orion A with XMM and Spitzer (SOXS). The YSOs are contained in a ring of gas and dust apparent at millimeter wavelengths, and in far-IR and near-IR surveys. The X-ray luminosity function of the young stellar objects detected in the two fields indicates a distance of 250-280 pc, much closer than the Orion A cloud and similar to distance estimates of $\\kappa$ Ori. We propose that the ring is a 5-8 pc diameter shell that has been swept up by $\\kappa$ Ori. This ring contains several groups of stars detected by Spitzer and WISE including one surrounding the Herbig Ae/Be stars V1818 Ori. In this interpretation, the $\\kappa$ ...

  18. FLUKA simulations and measurements for a dump for a 250 GeV/c hadron beam

    CERN Document Server

    Agosteo, S; Para, A; Silari, Marco; Ulrici, L

    2001-01-01

    FLUKA is a Monte Carlo code, transporting hadron and lepton cascades from several TeV down to a few keV (thermal energies for neutrons). The code is widely employed in various applications, such as particle detector design, shielding, radiation therapy, high energy physics experiments. The FLUKA results were compared with experimental data of dose equivalent and spectral fluence of neutrons produced by a 250 GeV/c proton/pion beam impinging on a beam dump installed in one of the secondary beam lines of the CERN super proton synchrotron (SPS). The dump is a shielding structure made of iron/concrete, designed to absorb completely the high-energy beam. The actual geometry of the clump was modeled in the simulations and the scoring of neutron track length was performed at various locations around it. Importance sampling and Russian Roulette mere used as variance reduction techniques. The simulations results were compared with experimental measurements performed with a Bonner sphere system for neutron spectrometry...

  19. Optical emission from a small scale model electric arc furnace in 250-600 nm region

    Science.gov (United States)

    Mäkinen, A.; Niskanen, J.; Tikkala, H.; Aksela, H.

    2013-04-01

    Optical emission spectroscopy has been for long proposed for monitoring and studying industrial steel making processes. Whereas the radiative decay of thermal excitations is always taking place in high temperatures needed in steel production, one of the most promising environment for such studies are electric arc furnaces, creating plasma in excited electronic states that relax with intense characteristic emission in the optical regime. Unfortunately, large industrial scale electric arc furnaces also present a challenging environment for optical emission studies and application of the method is not straightforward. To study the usability of optical emission spectroscopy in real electric arc furnaces, we have developed a laboratory scale DC electric arc furnace presented in this paper. With the setup, optical emission spectra of Fe, Cr, Cr2O3, Ni, SiO2, Al2O3, CaO, and MgO were recorded in the wavelength range 250-600 nm and the results were analyzed with the help of reference data. The work demonstrates that using characteristic optical emission, obtaining in situ chemical information from oscillating plasma of electric arc furnaces is indeed possible. In spite of complications, the method could possibly be applied to industrial scale steel making process in order to improve its efficiency.

  20. 三星SCH-S250拍照手机

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    这款拍照手机采用了三星同宾得合作推出的500万像素CCD影像传感器,具有1Ocm微距拍摄能力.快门速度达到1/1000s。机身上采用了:320×240像素的160万色QVGA TFD-LCD显示屏。可以进行文本朗读、以QVGA标准进行视频拍摄,内置了92MB的闪存.32MB系统内存。此外,它还支持TTS以及MP3播放能力等。具有MP3播放、支持视频输出并且兼容MMC存储卡。SCH-S250的机身尺寸为115mm×50mm×19mm,重量为116g。

  1. Analysis of Coastal Sediment Plume Dynamics in Puerto Rico using MODIS/Terra 250-m Imagery

    Science.gov (United States)

    Otis, D. B.; Muller-Karger, F. E.; Mendez-Lazaro, P.; McCarthy, M.; Chen, F. R.

    2014-12-01

    Anomalous events of suspended sediments can degrade water quality in nearshore ecosystems by reducing light penetration, inhibiting primary production, and delivering pollutants associated with the sediment particles. Coral reefs, for example, are subject to stress by anomalous sediment loads. The island of Puerto Rico has a diverse topography, with steep mountain slopes, episodic high-intensity rainfall events, and weathered soils that lead to episodes of high sediment volumes being delivered to the coastal zone by rivers. We developed a time series of turbidity observations based on Moderate Resolution Imaging Spectroradiometer (MODIS) imagery for use in the coastal areas of Puerto Rico. The product uses remote-sensing reflectance (Rrs) of Band 1 (645 nm) at a spatial resolution of 250 m. These estimates were compared to in-situ turbidity measurements collected in San Juan Bay. Sediment plumes from the major rivers of Puerto Rico were assessed quantitatively and compared with time-series of meteorological and other parameters, including precipitation, river discharge, and wind velocity. The spatial extent of plumes, the timing and duration of plume events, and their potential impact on coral reefs are examined. Results show that plume events are episodic and short-lived, but that they may affect coral reefs located several kilometers offshore.

  2. The Spectrum of Thorium from 250 nm to 5500 nm: Ritz Wavelengths and Optimized Energy Levels

    CERN Document Server

    Redman, Stephen L; Sansonetti, Craig J

    2013-01-01

    We have made precise observations of a thorium-argon hollow cathode lamp emission spectrum in the region between 350 nm and 1175 nm using a high-resolution Fourier transform spectrometer. Our measurements are combined with results from seven previously published thorium line lists (Giacchetti et al. 1974; Zalubas & Corliss 1974; Zalubas 1976; Palmer & Engleman 1983; Engleman et al. 2003; Lovis & Pepe 2007; Kerber et al. 2008) to re-optimize the energy levels of neutral, singly-, and doubly-ionized thorium (Th I, Th II, and Th III). Using the optimized level values, we calculate accurate Ritz wavelengths for 19679 thorium lines between 250 nm and 5500 nm (40000 1/cm to 1800 1/cm). We have also found 102 new thorium energy levels. A systematic analysis of previous measurements in light of our new results allows us to identify and propose corrections for systematic errors in Palmer & Engleman (1983) and typographical errors and incorrect classifications in Kerber et al. (2008). We also found a la...

  3. Updating the CSNS injector linac to 250 MeV with superconducting double-spoke cavities

    CERN Document Server

    Zhi-Hui, LI

    2014-01-01

    In order to update the beam power from 100 kW to 250 kW in China spallation neutron source (CSNS) Phase II, one of the important measures is to replace the 80 meters long beam transport line between the present 80 MeV linac injector and the RCS to another kind of acceleration structure. In this paper, we proposed a scheme based on 324 MHz double-spoke superconducting cavities. Unlike the superconducting elliptical cavity and normal conducting CCL structure, the double-spoke cavity belongs to TE mode structure and has smaller transvers dimension compared with that of TH mode one. It can work at base frequency as the DTL section, so that the cost and complexity of the RF system will be much decreased, and the behaviors of the beam dynamics are also improved significantly because of the low charge density and larger longitudinal acceptance. Furthermore, because of the relatively longer interactive length between charged particle and the electromagnetic field per cell, it needs relatively less cell numbers and it...

  4. A STAR-FORMING RING AROUND κ Ori 250 pc FROM THE SUN

    Energy Technology Data Exchange (ETDEWEB)

    Pillitteri, I.; Wolk, S. J. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Megeath, S. T., E-mail: ipillitt@cfa.harvard.edu [Ritter Astrophysical Research Center, Department of Physics and Astronomy, University of Toledo, Toledo, OH (United States)

    2016-04-01

    X-rays are a powerful probe of activity in early stages of star formation. They allow us to identify young stars even after they have lost the IR signatures of circumstellar disks and provide constraints on their distance. Here, we report on XMM-Newton observations that detect 121 young stellar objects (YSOs) in two fields between L1641 S and κ Ori. These observations extend the Survey of Orion A with XMM and Spitzer (SOXS). The YSOs are contained in a ring of gas and dust apparent at millimeter wavelengths, and in far-IR and near-IR surveys. The X-ray luminosity function of the YSOs detected in the two fields indicates a distance of 250–280 pc, much closer than the Orion A cloud and similar to distance estimates of κ Ori. We propose that the ring is a 5–8 pc diameter shell that has been swept up by κ Ori. This ring contains several groups of stars detected by Spitzer and WISE including one surrounding the Herbig Ae/Be stars V1818 Ori. In this interpretation, the κ Ori ring is one of several shells swept up by massive stars within the Orion Eridanus Superbubble and is unrelated to the southern portion of Orion A/L1641 S.

  5. Performance of a 512 x 512 Gated CMOS Imager with a 250 ps Exposure Time

    Energy Technology Data Exchange (ETDEWEB)

    Teruya, A T; Moody, J D; Hsing, W W; Brown, C G; Griffin, M; Mead, A S; Tran, V

    2012-10-01

    We describe the performance of a 512x512 gated CMOS read out integrated circuit (ROIC) with a 250 ps exposure time. A low-skew, H-tree trigger distribution system is used to locally generate individual pixel gates in each 8x8 neighborhood of the ROIC. The temporal width of the gate is voltage controlled and user selectable via a precision potentiometer. The gating implementation was first validated in optical tests of a 64x64 pixel prototype ROIC developed as a proof-of-concept during the early phases of the development program. The layout of the H-Tree addresses each quadrant of the ROIC independently and admits operation of the ROIC in two modes. If “common mode” triggering is used, the camera provides a single 512x512 image. If independent triggers are used, the camera can provide up to four 256x256 images with a frame separation set by the trigger intervals. The ROIC design includes small (sub-pixel) optical photodiode structures to allow test and characterization of the ROIC using optical sources prior to bump bonding. Reported test results were obtained using short pulse, second harmonic Ti:Sapphire laser systems operating at λ~ 400 nm at sub-ps pulse widths.

  6. Utilization and operating experience of the 250 kw TRIGA Mark II research reactor in Ljubljana

    International Nuclear Information System (INIS)

    In its 35th year, the TRIGA Mark II 250 kW pulsing research reactor in Ljubljana is continuing its busy operation. With the maximum neutron flux in the central thimble of 10 13 n/cm 2 sec and many sample radiation positions the reactor has been used to perform many experiments in the following fields: solid state physics (elastic and inelastic neutron scattering), neutron dosimetry, neutron radiography, reactor physics including burn up measurements and calculations, boron neutron capture therapy and neutron activation analysis which represents one of the major usage of our reactor. Besides these, applied research around the reactor has been conducted, such as doping of silicon monocrystals, a routine production of various radioactive isotopes for industry ( 60Co, 64Zn, 24Na, 82Br) and medical use ( 18F, 99m Tc, etc.) and other activities. During the past decade the reactor was almost completely reconstructed (new grid plates, the control mechanisms and the control unit, modification of the spent fuel storage pool, etc). The main novelty in the reactor physics and operation features of the reactor was the installation of a pulse rod, therefore the reactor can be operated in a pulse mode. After reconstruction, the core was loaded with fresh 20% enriched fuel elements. In 1999 all spent fuel elements were shipped to the USA. (author)

  7. Isolation of a 250 million-year-old halotolerant bacterium from a primary salt crystal

    Science.gov (United States)

    Vreeland, Russell H.; Rosenzweig, William D.; Powers, Dennis W.

    2000-10-01

    Bacteria have been found associated with a variety of ancient samples, however few studies are generally accepted due to questions about sample quality and contamination. When Cano and Borucki isolated a strain of Bacillus sphaericus from an extinct bee trapped in 25-30 million-year-old amber, careful sample selection and stringent sterilization techniques were the keys to acceptance. Here we report the isolation and growth of a previously unrecognized spore-forming bacterium (Bacillus species, designated 2-9-3) from a brine inclusion within a 250million-year-old salt crystal from the Permian Salado Formation. Complete gene sequences of the 16S ribosomal DNA show that the organism is part of the lineage of Bacillus marismortui and Virgibacillus pantothenticus. Delicate crystal structures and sedimentary features indicate the salt has not recrystallized since formation. Samples were rejected if brine inclusions showed physical signs of possible contamination. Surfaces of salt crystal samples were sterilized with strong alkali and acid before extracting brines from inclusions. Sterilization procedures reduce the probability of contamination to less than 1 in 10 9.

  8. Partial covering of emission regions of Q 0528-250 by intervening H$_2$ clouds

    CERN Document Server

    Klimenko, V V; Ivanchik, A V; Ledoux, C; Noterdaeme, P; Petitjean, P; Srianand, R; Varshalovich, D A

    2015-01-01

    We present an analysis of the molecular hydrogen absorption system at z$_{\\rm abs}$ = 2.811 in the spectrum of the blazar Q0528-250. We demonstrate that the molecular cloud does not cover the background source completely. The partial coverage reveals itself as a residual flux in the bottom of saturated H_2 absorption lines. This amounts to about (2.22$\\pm$0.54)% of the continuum and does not depend on the wavelength. This value is small and it explains why this effect has not been detected in previous studies of this quasar spectrum. However, it is robustly detected and significantly higher than the zero flux level in the bottom of saturated lines of the Ly-alpha forest, (-0.21$\\pm$0.22)%. The presence of the residual flux could be caused by unresolved quasar multicomponents, by light scattered by dust, and/or by jet-cloud interaction. The H$_2$ absorption system is very well described by a two-component model without inclusion of additional components when we take partial coverage into account. The derived t...

  9. Tumor-Targeted Nanomedicines

    Science.gov (United States)

    ElBayoumi, Tamer A.; Torchilin, Vladimir P.

    2009-01-01

    Purpose The efficacy of drug delivery systems can be enhanced by making them target-specific via the attachment of various ligands. We attempted to enhance tumor accumulation and therapeutic effect of doxorubicin-loaded long-circulating PEGylated liposomes (Doxil®, ALZA Corp.) by coupling to their surface the anti-cancer monoclonal antibody 2C5 (mAb 2C5) with nuclesome (NS)-restricted activity, that can recognize the surface of various tumor but not normal cells and specifically targets pharmaceutical carriers to tumor cells in vitro and in vivo. Following earlier in vitro results with various cancer cell lines, the mAb 2C5-liposomes were studied in vivo vs. plain and non-specific IgG-liposomes. Experimental design Antibody coupling to Doxil® was performed via the “post-insertion” technique. Using 111In-labeled liposomes, the tissue biodistribution and pharmacokinetic profile were studied, as well as their accumulation in tumors in mice was followed by the whole-body γ-scintigraphic imaging. Therapeutic efficacy of mAb 2C5-targeted Doxil® vs. non-specific IgG-modified and original Doxil® controls was followed by registering live tumor growth and determining tumor weights upon mice sacrifice. Results mAb2C5 antibody-targeted liposomes demonstrate enhanced accumulation in tumors, and the in vivo therapeutic activity of the mAb 2C5-Doxil® treatment was found to be significantly superior, resulting in final tumor weights of only 25-40% compared to all Doxil® control treatments, when tested against the subcutaneous primary murine tumors of 4T1 and C26 and human PC3 tumor in nude mice. Conclusions Our results demonstrate the remarkable capability of 2C5-targeted Doxil® to specifically deliver its cargo into various tumors significantly increasing the efficacy of therapy. PMID:19276264

  10. Application of CMT Cold Metal Transfer Welding Technology in HT250 Repair Welding%CMT冷金属过渡焊接技术在HT250灰铸铁补焊中的应用

    Institute of Scientific and Technical Information of China (English)

    杨新华; 管志花

    2013-01-01

    阐述了利用CMT冷金属过渡方法补焊HT250灰铸铁的焊接工艺及补焊结果,主要从CMT冷金属过渡方法的特点、HT250灰铸铁焊接工艺和补焊质量3个方面进行了论述和试验研究,总结CMT自动焊技术在补焊铸铁方面的经验,为灰铸铁铸件的补焊提供科学依据和技术参考.%The welding process and the welding result of HT250 gray cast iron using CMT cold metal transfer welding methods were described,that is mainly discussed and researched from three aspects of the characteristics of CMT cold metal transfer method,welding process and welding quality of HT250 gray cast iron.The experience of CMT automatic welding technology in welding of cast iron was summarized,which provide scientific basis and technical references for repair welding of grey iron castings.

  11. 合成大麻素JWH-250的高效液相色谱分析方法研究%Determination of Synthetic Cannabinoid JWH-250 by HPLC

    Institute of Scientific and Technical Information of China (English)

    苗翠英; 邱志远; 翟晚枫; 魏巍; 全雪峰; 王兆玉

    2015-01-01

    Objective As one kind of the most popular designer drugs, synthetic cannabinoid has been presenting a tough challenge for law enforcement and public security officials. JWH-250, one of the phenacyl-indoles abused all around the world, has recently been included under the latest Psychotropic Drug Directory by Chinese government. In order to improve the accuracy and sensitivity of determining JWH-250 in actual cases and enrich the research means for this drug, high performance liquid chromatography (HPLC) was utilized. Methods Chromatographic parameters were tested and optimized based on the performance of least interference to the results quality and repeatedness, together with the ascertainment of linear relationship, precision and stability. Eventually, the ideal conditions for detection of the synthetic cannabinoid JWH-250 by HPLC were established. Results Under optimized conditions (UV wavelength at 214 nm, initial concentration of the organic phase of 63%, gradient steepness of 4.2%/min, flow rate of 0.8 mL/min, and column temperature of 34°C), a good linearity was achieved over the range of 2~100 μg/ml, with the correlation coefficient R=0.9999649 and limit of detection(S/N≥3) as to 0.1 μg/mL. The precision was good with the intra-day and inter-day RSDs less than 0.59% and 1.74%, respectively. JWH-250 can be completely separated from Δ9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD). Conclusions The method is rapid, sensitive and accurate, applicable to quantitative determination of the synthetic cannabinoid JWH-250 by validation experiment of a sample from an actual case, a promising choice for providing technical support to prevent and combat the drug-related criminal activities.%目的:建立合成大麻素 JWH-250的高效液相色谱分析方法。方法考查梯度洗脱的有机相初始浓度和梯度洗脱的陡度、流速、柱温、检测波长等参数,初步建立 JWH250的高效液相色谱分析方法,并对专

  12. Evidence for the presence of R250G mutation at the ATPase domain of topoisomerase II in an arsenite-resistant Leishmania donovani exhibiting a differential drug inhibition profile.

    Science.gov (United States)

    Singh, Gaganmeet; Thakur, Meghna; Chakraborti, Pradip K; Dey, Chinmoy S

    2009-01-01

    Resistance to operational drugs is a major barrier to successful antileishmanial chemotherapy that demands development of novel drug intervention strategies based on rational approaches. Model drug resistance phenotypes, such as arsenite resistance used in the current study, facilitate our understanding of the mechanism of drug resistance and assist in identifying new drug target(s). The current study was undertaken to investigate the sensitivity of topoisomerase II (topo II) of arsenite-sensitive (Ld-Wt) and -resistant (Ld-As20) Leishmania donovani to antileishmanial/anti-topo II agents. The effect of antileishmanial/anti-topo II drugs on partially purified topo II enzyme from Ld-Wt and Ld-As20 revealed differential inhibition of topo II decatenation activity for the two strains, with a lower amount of drug required to inhibit activity by 50% in Ld-Wt compared with Ld-As20. Comparison of topo II sequences from both strains indicated a point mutation, R250G, in the ATPase domain of the resistant strain. Furthermore, the Arg-250 of the ATPase domain of topo II was observed to be conserved throughout different species of Leishmania. Variation in the topo II gene sequence between Ld-Wt and Ld-As20 is envisaged to be responsible for the differential behaviour of the enzymes from the two sources. PMID:18805675

  13. Polarization discrimination between repeater false-target and radar target

    Institute of Scientific and Technical Information of China (English)

    SHI LongFei; WANG XueSong; XIAO ShunPing

    2009-01-01

    High fidelity repeater false-target badly affects a radar system's detecting, tracking, and data processing. It is an available approach of confronting false-target for radar that discriminates firstly and then eliminates. Whereas for the technique progress about the repeater false-target jam, it is more and more difficult to discriminate this jam in the time-domain, frequency-domain, or space-domain. The technique using polarization information to discriminate the target and false-target is discussed in this paper. With the difference that false-target signal vector's polarization ratio is fixed and target echo signal vector's polarization ratio is variational along with radar transmission signal's polarization, we transform the discrimination problem to beeline distinguish problem in the 2-dim complex space. The distributing characteristic expression of the false-target discrimination statistic is constructed, with which the discrimination ratio of false-target is analyzed. For the target case, the decomposed model of target scattering matrix and the concept of distinguish quantity are proposed. Then, the discrimination ratio of target can be forecasted according to target distinguish quantity. Thus, the performance of discrimination method has been analyzed integrally. The simulation results demonstrate the method in this paper is effective on the discrimination of target and false-target.

  14. Shiprock, AZ NM CO UT 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  15. 30 CFR 250.1163 - How must I measure gas flaring or venting volumes and liquid hydrocarbon burning volumes, and...

    Science.gov (United States)

    2010-07-01

    ..., and Burning Hydrocarbons § 250.1163 How must I measure gas flaring or venting volumes and liquid... vented, and liquid hydrocarbons burned, to Minerals Revenue Management on Form MMS-4054 (Oil and Gas... gas flaring, gas venting, and liquid hydrocarbon burning for each facility for 6 years. (1) You...

  16. Evaluation of the Performance of Vortex Generators on the DU 91-W2-250 Profile using Stereoscopic PIV

    DEFF Research Database (Denmark)

    Velte, Clara Marika; Hansen, Martin Otto Laver; Meyer, Knud Erik;

    2008-01-01

    Stereoscopic PIV measurements investigating the effect of Vortex Generators on the lift force near stall and on glide ratio at best aerodynamic performance have been carried out in the LM Glasfiber wind tunnel on a DU 91-W2-250 profile. Measurements at two Reynolds numbers were analyzed; Re=0...

  17. Evaluation of the Performance of Vortex Generators on the DU 91-W2-250 Profile using Stereoscopic PIV

    DEFF Research Database (Denmark)

    Velte, Clara Marika; Hansen, Martin Otto Laver; Meyer, Knud Erik;

    2009-01-01

    Stereoscopic PIV measurements investigating the effect of Vortex Generators on the lift force near stall and on glide ratio at best aerodynamic performance have been carried out in the LM Glasfiber wind tunnel on a DU 91-W2-250 profile. Measurements at two Reynolds numbers were analyzed; Re=0...

  18. 41 CFR 102-73.250 - Are agencies required to adhere to the policies for locating Federal facilities when purchasing...

    Science.gov (United States)

    2010-07-01

    ...-73.250 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 73-REAL ESTATE ACQUISITION Acquisition by Purchase or... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Are agencies required...

  19. Hexakis(urea-jO)zinc(II) dinitrate at 110 and 250 K: uniaxial negative thermal expansion

    NARCIS (Netherlands)

    Smeets, S.; Lutz, M.

    2011-01-01

    The crystal structure of the title compound, [Zn{CO(NH2)2}6]- (NO3)2, has been determined at 110 and 250 K. The structure is stabilized by 12 individual hydrogen bonds, both intra- and intermolecular. Analysis of the thermal expansion tensor, based on unit cells determined over a temperature range o

  20. 19 CFR 123.7 - Manifest used as an entry for unconditionally free merchandise value not over $250.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Manifest used as an entry for unconditionally free merchandise value not over $250. 123.7 Section 123.7 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS RELATIONS WITH CANADA AND MEXICO General Provisions § 123.7 Manifest used...

  1. 30 CFR 250.108 - What requirements must I follow for cranes and other material-handling equipment?

    Science.gov (United States)

    2010-07-01

    ... Petroleum Institute's Recommended Practice for Operation and Maintenance of Offshore Cranes (API RP 2D... for Offshore Pedestal Mounted Cranes (API Spec 2C), incorporated by reference as specified in 30 CFR... meet the requirements of API Spec 2C, incorporated by reference as specified in 30 CFR 250.198. (e)...

  2. Radioimmunotheapy with [I-131]cG250 in patients with metastasized renal cell cancer : Dosimetric analysis and immunologic response

    NARCIS (Netherlands)

    Brouwers, AH; Buijs, WCAM; Mulders, PFA; de Mulder, PHM; van den Broek, WJM; Mala, C; Oosterwijk, E; Boerman, OC; Corstens, FHM; Oyen, WJG

    2005-01-01

    Purpose: A study was designed to define the therapeutic efficacy, safety, and toxicity of two sequential high-dose treatments of radioimmunotherapy with [I-131]cG250 in patients with metastasized renal cell carcinoma. Here, we report the dosimetric analysis and the relationship between the developme

  3. 30 CFR 250.245 - What hydrogen sulfide (H2S) information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ... analysis must be consistent with the EPA's risk management plan methodologies outlined in 40 CFR part 68. ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What hydrogen sulfide (H2S) information must... Documents (docd) § 250.245 What hydrogen sulfide (H2S) information must accompany the DPP or DOCD?...

  4. 78 FR 20326 - Draft Compliance Policy Guide Sec. 100.250 Food Facility Registration-Human and Animal Food...

    Science.gov (United States)

    2013-04-04

    ... HUMAN SERVICES Food and Drug Administration Draft Compliance Policy Guide Sec. 100.250 Food Facility Registration--Human and Animal Food; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of draft Compliance...

  5. Operation, maintenance, and utilization of 250 kW TRIGA Mark II reactor at the Institute Jozef Stefan, Ljubljana (Yugoslavia))

    International Nuclear Information System (INIS)

    At the Institute 'Jozef Stefan' in Ljubljana 250 kW TRIGA Mark II Reactor has been in operation since May 31, 1966. It is the steady state operated reactor without pulsing capabilities. In the paper the operational data, maintenance and utilization of the reactor are summarized for the first four years of reactor operation. (author)

  6. 30 CFR 250.1729 - After I remove a platform or other facility, what information must I submit?

    Science.gov (United States)

    2010-07-01

    ... Decommissioning Activities Removing Platforms and Other Facilities § 250.1729 After I remove a platform or other facility, what information must I submit? Within 30 days after you remove a platform or other facility, you... 30 Mineral Resources 2 2010-07-01 2010-07-01 false After I remove a platform or other...

  7. Dalhart, NM OK TX CO 1:250,000 Quad USGS Land Use/Land Cover, 1986

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset contains boundaries for land use and land cover polygons in New Mexico at a scale of 1:250,000. It is in a vector digital data structure. The source...

  8. Evolution with Drifting Targets

    CERN Document Server

    Kanade, Varun; Vaughan, Jennifer Wortman

    2010-01-01

    We consider the question of the stability of evolutionary algorithms to gradual changes, or drift, in the target concept. We define an algorithm to be resistant to drift if, for some inverse polynomial drift rate in the target function, it converges to accuracy 1 -- \\epsilon , with polynomial resources, and then stays within that accuracy indefinitely, except with probability \\epsilon , at any one time. We show that every evolution algorithm, in the sense of Valiant (2007; 2009), can be converted using the Correlational Query technique of Feldman (2008), into such a drift resistant algorithm. For certain evolutionary algorithms, such as for Boolean conjunctions, we give bounds on the rates of drift that they can resist. We develop some new evolution algorithms that are resistant to significant drift. In particular, we give an algorithm for evolving linear separators over the spherically symmetric distribution that is resistant to a drift rate of O(\\epsilon /n), and another algorithm over the more general prod...

  9. Modelling Recycling Targets

    DEFF Research Database (Denmark)

    Hill, Amanda Louise; Leinikka Dall, Ole; Andersen, Frits M.

    2014-01-01

    the existing technological, organizational and legislative frameworks may affect recycling activities. The results of the analysis show that with current best practice recycling rates, the 50% recycling rate cannot be reached without recycling of household biowaste. It also shows that all Danish municipalities...... will need to make efforts to recover all recyclable fractions, and that the increased recycling efforts of only selected municipalities will not be sufficient to reach the target.......Within the European Union (EU) a paradigm shift is currently occurring in the waste sector, where EU waste directives and national waste strategies are placing emphasis on resource efficiency and recycling targets. The most recent Danish resource strategy calculates a national recycling rate of 22...

  10. Physics of polarized targets

    CERN Document Server

    Niinikoski, Tapio

    2014-01-01

    For developing, building and operating solid polarized targets we need to understand several fields of physics that have seen sub stantial advances during the last 50 years. W e shall briefly review a selection of those that are important today. These are: 1) quantum statistical methods to describe saturation and relaxation in magnetic resonance; 2) equal spin temperature model for dy namic nuclear polarization; 3 ) weak saturation during NMR polarization measurement; 4 ) refrigeration using the quantum fluid properties of helium isotopes. These, combined with superconducting magnet technologies, permit today to reach nearly complete pola rization of almost any nuclear spins. Targets can be operated in frozen spin mode in rather low and inhomogeneous field of any orientation, and in DNP mode in beams of high intensity. Beyond such experiments of nuclear and particle physics, applications a re also emerging in macromolecular chemistry and in magnetic resonance imaging. This talk is a tribute to Michel Borghini...

  11. Gene Targeting in Neuroendocrinology.

    Science.gov (United States)

    Candlish, Michael; De Angelis, Roberto; Götz, Viktoria; Boehm, Ulrich

    2015-09-20

    Research in neuroendocrinology faces particular challenges due to the complex interactions between cells in the hypothalamus, in the pituitary gland and in peripheral tissues. Within the hypothalamus alone, attempting to target a specific neuronal cell type can be problematic due to the heterogeneous nature and level of cellular diversity of hypothalamic nuclei. Because of the inherent complexity of the reproductive axis, the use of animal models and in vivo experiments are often a prerequisite in reproductive neuroendocrinology. The advent of targeted genetic modifications, particularly in mice, has opened new avenues of neuroendocrine research. Within this review, we evaluate various mouse models used in reproductive neuroendocrinology and discuss the different approaches to generate genetically modified mice, along with their inherent advantages and disadvantages. We also discuss a variety of versatile genetic tools with a focus on their potential use in reproductive neuroendocrinology.

  12. Design of ignition targets for the National Ignition Facility (IFSA 1999)

    Science.gov (United States)

    Haan, Steven W.; Dittrich, T. R.; Marinak, M. M.; Hinkel, D. E.

    2016-10-01

    This is a brief update on the work being done to design ignition targets for the National Ignition Facility. Updates are presented on three areas of current activity; improvements in modeling, work on a variety of targets spanning the parameter space of possible ignition targets; and the setting of specifications for target fabrication and diagnostics. Highlights of recent activity include; a simulation of the Rayleigh-Taylor instability growth on in imploding capsule, done in 3D on a 70° by 70° wedge, with enough zones to resolve modes out to 100; and designs of targets at 250eV and 350eV, as well as the baseline 300 eV; and variation of the central DT gas density, which influences both the Rayleigh-Taylor growth and the smoothness of the DT ice layer.

  13. Targeting fragile X

    OpenAIRE

    Gantois, Ilse; Kooy, R. Frank

    2002-01-01

    Ten years after the identification of the gene responsible for fragile X syndrome, recent studies have revealed a list of mRNAs bound by the fragile X gene product and have identified specific sequences required for the interaction between the fragile X protein and its targets. These results are a breakthrough in understanding why absence of the fragile X protein leads to mental retardation.

  14. Time reversal optical tomography locates fluorescent targets in a turbid medium

    Science.gov (United States)

    Wu, Binlin; Cai, W.; Gayen, S. K.

    2013-03-01

    A fluorescence optical tomography approach that extends time reversal optical tomography (TROT) to locate fluorescent targets embedded in a turbid medium is introduced. It uses a multi-source illumination and multi-detector signal acquisition scheme, along with TR matrix formalism, and multiple signal classification (MUSIC) to construct pseudo-image of the targets. The samples consisted of a single or two small tubes filled with water solution of Indocyanine Green (ICG) dye as targets embedded in a 250 mm × 250 mm × 60 mm rectangular cell filled with Intralipid-20% suspension as the scattering medium. The ICG concentration was 1μM, and the Intralipid-20% concentration was adjusted to provide ~ 1-mm transport length for both excitation wavelength of 790 nm and fluorescence wavelength around 825 nm. The data matrix was constructed using the diffusely transmitted fluorescence signals for all scan positions, and the TR matrix was constructed by multiplying data matrix with its transpose. A pseudo spectrum was calculated using the signal subspace of the TR matrix. Tomographic images were generated using the pseudo spectrum. The peaks in the pseudo images provided locations of the target(s) with sub-millimeter accuracy. Concurrent transmission TROT measurements corroborated fluorescence-TROT findings. The results demonstrate that TROT is a fast approach that can be used to obtain accurate three-dimensional position information of fluorescence targets embedded deep inside a highly scattering medium, such as, a contrast-enhanced tumor in a human breast.

  15. Surface circulation patterns in the Gulf of California derived from MODIS Aqua 250 m

    Science.gov (United States)

    Martínez-Flores, G.; Salinas-González, F.; Gutiérrez de Velasco-Sanromán, G.; Godínez-Orta, L.

    2009-04-01

    The Gulf of California (GC) is a marginal elongated and semi-enclosed sea located at northwest of Mexico, between the Peninsula of Baja California and the mainland Mexico. The considered area average 150 km in width and 1500 km in length, from the mouth of the Colorado River to Cabo Corrientes, Jalisco. It has a maximum depth of 3600 m at the southern inlet and the northern region average 200 m in deep. The study of superficial circulation patterns in the GC is of interest because its relevance to the mechanisms of transport for distribution of a variety of materials -plankton, contaminants, microalgae, etc.- and its association with areas of sedimentary deposits, zones where there is a higher probability for fishing or related to the presence of certain species of marine life. Recent studies explain the circulation of the GC as a result of the Pacific Ocean's forcing, wind, heat fluxes on the sea surface and the interaction between the flow produced by these agents and bathymetry. The objective of this work was to obtain evidence of the patterns of surface circulation using a spatial resolution of 250 m over a period of two to seven days (depending on cloud cover), which offered images from the MODIS Level 1B. This essay is an attempt to contribute with more information to the understanding of the regional dynamics of the GC and its local influence on the zones bordering the coast. Thus, MODIS Aqua 250 m data was used, to which algorithms were applied in order to enhance the contrast of reflectance levels of these bands (0.620-0.670 and 0.841-0.876 µm) within the marine environment. The results are associated with suspended particulate matter (SPM), which we used as tracers of the surface circulation, using a sequence of images from January 2004 to December 2008. Algorithms for dust and cloud detection were used and incorporated with thermal band images, in which zones of terrigenous contribution by eolian transport were identified. Furthermore, pluvial

  16. Follicular penetration and targeting.

    Science.gov (United States)

    Lademann, Jürgen; Otberg, Nina; Jacobi, Ute; Hoffman, Robert M; Blume-Peytavi, Ulrike

    2005-12-01

    In the past, intercellular penetration was assumed to be the most important penetration pathway of topically applied substances. First hints that follicular penetration needs to be taken into consideration were confirmed by recent investigations, presented during the workshop "Follicular Penetration and Targeting" at the 4th Intercontinental Meeting of Hair Research Societies", in Berlin 2004. Hair follicles represent an efficient reservoir for the penetration of topically applied substances with subsequent targeting of distinct cell populations, e.g., nestin-expressing follicular bulge cells. The volume of this reservoir can be determined by differential stripping technology. The follicular penetration processes are significantly influenced by the state of the follicular infundibulum; recent experimental investigations could demonstrate that it is essential to distinguish between open and closed hair follicles. Topically applied substances can only penetrate into open hair follicle. Knowledge of follicular penetration is of high clinical relevance for functional targeting of distinct follicular regions. Human hair follicles show a hair-cycle-dependent variation of the dense neuronal and vascular network. Moreover, during hair follicle cycling with initiation of anagen, newly formed vessels occur. Thus, the potential of nestin-expressing hair follicle stem cells to form neurons and blood vessels was investigated.

  17. Study for optimization of a 60 Co industrial irradiator of 250 k Ci

    International Nuclear Information System (INIS)

    This work presents results of a benchmark between calculated and experimental absorbed dose values for a typical product, in a 60 Co industrial irradiator, located at ININ, Mexico. The goal of this work is to reach a ± 10 % approximation between both values. ININ 60 Co industrial irradiator is a two level, two layer system with overlapping product configuration, 56 irradiation positions with an activity of around 250 k Ci. Calculated values were obtained by QAD-CGGP code. This code uses a point kernel technique, build-up factors fitting was done by geometrical progression and combinatorial geometry was used for 3 D system description. Main code modifications were related with source simulation by punctual sources and energy spectrum (16 energy groups) and anisotropic emission were also considered. Experimental data were obtained from routine dosimetry which was done with red acrylic pellets; they were irradiated together the product in predetermined positions, for 36 maximum and minimum absorbed dose values. Typical product was polypropylene Petri dish packages, apparent density 0.13 g/cm3. It was chosen because regular geometry (2 packages per full irradiator container) and enough amount for considering homogeneous loading inside irradiation chamber. Required minimum dose was 15 kGy. Results showed a 8% variation between calculated and experimental values for maximum absorbed dose (18.2 kGy vs 16.8 kGy) and 3 % variation for minimum absorbed dose (13.8 kGy vs 14.3 kGy); these results fixed with the original proposal. (Author)

  18. Study on discharge heat utilization of 250 MWe PCMSR turbine system for desalination using modified MED

    International Nuclear Information System (INIS)

    PCMSR (Passive Compact Molten Salt Reactor) is one type of Advanced Nuclear Reactors. The PCMSR has benefit characteristics of very efficient fuel use, high safety characteristic as well as high thermodynamics efficiency. This is due to its breeding capability, inherently safe characteristic and totally passive safety system. The PCMSR design consists of three module, i.e. reactor module, turbine module and fuel management module. Analysis in performed by parametric calculation of the turbine system to calculate the turbine system efficiency and the hat available for desalination. After that the mass and energy balance of desalination process are calculated to calculate the amount of distillate produced and the amount of feed sea water needed. The turbine module is designed to be operated at maximum temperature cycle of 1373 K (1200 °C) and minimum temperature cycle of 333 K (60 °K). The parametric calculation shows that the optimum turbine pressure ratio is 4.3 that gives the conversion efficiency of 56 % for 4 stages turbine and 4 stages compressor and equipped with recuperator. In this optimum condition, the 250 MWe PCMSR turbine system produces 196 MWth of waste heat with the temperature of cooling fluid in the range from 327 K (54°C) to 368 K (95 °C). This waste heat can be utilized for desalination. By using MMED desalination system, this waste heat can be used to produce fresh water (distillate) from sea water feed. The amount of the distillate produced is 48663 ton per day by using 15 distillation effects. The performance ratio value is 2.8727 with by using 15 distillation effects. (author)

  19. High Resolution PET with 250 micrometer LSO Detectors and Adaptive Zoom

    Energy Technology Data Exchange (ETDEWEB)

    Cherry, Simon R.; Qi, Jinyi

    2012-01-08

    There have been impressive improvements in the performance of small-animal positron emission tomography (PET) systems since their first development in the mid 1990s, both in terms of spatial resolution and sensitivity, which have directly contributed to the increasing adoption of this technology for a wide range of biomedical applications. Nonetheless, current systems still are largely dominated by the size of the scintillator elements used in the detector. Our research predicts that developing scintillator arrays with an element size of 250 {micro}m or smaller will lead to an image resolution of 500 {micro}m when using 18F- or 64Cu-labeled radiotracers, giving a factor of 4-8 improvement in volumetric resolution over the highest resolution research systems currently in existence. This proposal had two main objectives: (i) To develop and evaluate much higher resolution and efficiency scintillator arrays that can be used in the future as the basis for detectors in a small-animal PET scanner where the spatial resolution is dominated by decay and interaction physics rather than detector size. (ii) To optimize one such high resolution, high sensitivity detector and adaptively integrate it into the existing microPET II small animal PET scanner as a 'zoom-in' detector that provides higher spatial resolution and sensitivity in a limited region close to the detector face. The knowledge gained from this project will provide valuable information for building future PET systems with a complete ring of very high-resolution detector arrays and also lay the foundations for utilizing high-resolution detectors in combination with existing PET systems for localized high-resolution imaging.

  20. High Resolution PET with 250 micrometer LSO Detectors and Adaptive Zoom

    International Nuclear Information System (INIS)

    There have been impressive improvements in the performance of small-animal positron emission tomography (PET) systems since their first development in the mid 1990s, both in terms of spatial resolution and sensitivity, which have directly contributed to the increasing adoption of this technology for a wide range of biomedical applications. Nonetheless, current systems still are largely dominated by the size of the scintillator elements used in the detector. Our research predicts that developing scintillator arrays with an element size of 250 (micro)m or smaller will lead to an image resolution of 500 (micro)m when using 18F- or 64Cu-labeled radiotracers, giving a factor of 4-8 improvement in volumetric resolution over the highest resolution research systems currently in existence. This proposal had two main objectives: (i) To develop and evaluate much higher resolution and efficiency scintillator arrays that can be used in the future as the basis for detectors in a small-animal PET scanner where the spatial resolution is dominated by decay and interaction physics rather than detector size. (ii) To optimize one such high resolution, high sensitivity detector and adaptively integrate it into the existing microPET II small animal PET scanner as a 'zoom-in' detector that provides higher spatial resolution and sensitivity in a limited region close to the detector face. The knowledge gained from this project will provide valuable information for building future PET systems with a complete ring of very high-resolution detector arrays and also lay the foundations for utilizing high-resolution detectors in combination with existing PET systems for localized high-resolution imaging.

  1. Statistics and scaling of turbulence in a spatially developing mixing layer at Reλ = 250

    KAUST Repository

    Attili, Antonio

    2012-03-21

    The turbulent flow originating from the interaction between two parallel streams with different velocities is studied by means of direct numerical simulation. Rather than the more common temporal evolving layer, a spatially evolving configuration, with perturbed laminar inlet conditions is considered. The streamwise evolution and the self-similar state of turbulence statistics are reported and compared to results available in the literature. The characteristics of the transitional region agree with those observed in other simulations and experiments of mixing layers originating from laminar inlets. The present results indicate that the transitional region depends strongly on the inlet flow. Conversely, the self-similar state of turbulent kinetic energy and dissipation agrees quantitatively with those in a temporal mixing layer developing from turbulent initial conditions [M. M. Rogers and R. D. Moser, “Direct simulation of a self-similar turbulent mixing layer,” Phys. Fluids6, 903 (1994)]. The statistical features of turbulence in the self-similar region have been analysed in terms of longitudinal velocity structure functions, and scaling exponents are estimated by applying the extended self-similarity concept. In the small scale range (60 < r/η < 250), the scaling exponents display the universal anomalous scaling observed in homogeneous isotropic turbulence. The hypothesis of isotropy recovery holds in the turbulent mixing layer despite the presence of strong shear and large-scale structures, independently of the means of turbulence generation. At larger scales (r/η > 400), the mean shear and large coherent structures result in a significant deviation from predictions based on homogeneous isotropic turbulence theory. In this second scaling range, the numerical values of the exponents agree quantitatively with those reported for a variety of other flows characterized by strong shear, such as boundary layers, as well as channel and wake flows.

  2. Preparation and In vitro Investigation of Chitosan Compressed Tablets for Colon Targeting

    OpenAIRE

    Negar Bashardoust; Josephine Leno Jenita; Parvin Zakeri-Milani

    2011-01-01

    Purpose: The aim of the present study was minimizing the drug release in upper gastro intestinal tract and targeting to colon by using the principles of compression coat. Methods: Compression coated tablets of Ibuprofen were prepared by direct compression method using chitosan (300, 250, 200 & 175 mg). Tablets were evaluated for their physicochemical properties and in vitro drug release studies. In vitro drug release studies were performed with and without rat caecal contents. Results: In the...

  3. Inflation targeting and core inflation

    OpenAIRE

    Julie Smith

    2005-01-01

    This paper examines the interaction of core inflation and inflation targeting as a monetary policy regime. Interest in core inflation has grown because of inflation targeting. Core inflation is defined in numerous ways giving rise to many potential measures; this paper defines core inflation as the best forecaster of inflation. A cross-country study finds before the start of inflation targeting, but not after, core inflation differs between non-inflation targeters and inflation targeters. Thr...

  4. Geochemical provenance of anomalous metal concentrations in stream sediments in the Ashton 1:250,000 quadrangle, Idaho/Montana/Wyoming

    International Nuclear Information System (INIS)

    Stream-sediment samples from 1500 sites in the Ashton, Idaho/Montana/Wyoming 1:250,000 quadrangle were analyzed for 45 elements. Almost all samples containing anomalous concentrations (exceeding one standard deviation above the mean value of any element) were derived from drainage basins underlain by Quaternary rhyolite, Tertiary andesite or Precambrian gneiss and schist. Aluminum, barium, calcium, cobalt, iron, nickel, magnesium, scandium, sodium, strontium, and vanadium have no andesite provenance. Most anomalous manganese, europium, hafnium, and zirconium values were derived from Precambrian rocks. All other anomalous elemental concentrations are related to Quaternary rhyolite. This study demonstrates that multielemental stream-sediment analyses can be used to infer the provenance of stream sediments. Such data are available for many parts of the country as a result of the National Uranium Resource Evaluation. This study suggests that stream-sediment samples collected in the Rocky Mountains can be used either as pathfinders or as direct indicators to select targets for mineral exploration for a host of metals

  5. Targeted therapy for sarcomas

    Directory of Open Access Journals (Sweden)

    Forscher C

    2014-03-01

    Full Text Available Charles Forscher,1 Monica Mita,2 Robert Figlin3 1Sarcoma Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; 2Experimental Therapeutics Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; 3Academic Development Program, Samuel Oschin Comprehensive Cancer Institute, and Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA Abstract: Sarcomas are tumors of mesenchymal origin that make up approximately 1% of human cancers. They may arise as primary tumors in either bone or soft tissue, with approximately 11,280 soft tissue tumors and 2,650 bone tumors diagnosed each year in the United States. There are at least 50 different subtypes of soft tissue sarcoma, with new ones described with ever-increasing frequency. One way to look at sarcomas is to divide them into categories on the basis of their genetic make-up. One group of sarcomas has an identifiable, relatively simple genetic signature, such as the X:18 translocation seen in synovial sarcoma or the 11:22 translocation seen in Ewing's sarcoma. These specific abnormalities often lead to the presence of fusion proteins, such as EWS-FLI1 in Ewing's sarcoma, which are helpful as diagnostic tools and may become therapeutic targets in the future. Another group of sarcomas is characterized by complex genetic abnormalities as seen in leiomyosarcoma, osteosarcoma, and undifferentiated sarcoma. It is important to keep these distinctions in mind when contemplating the development of targeted agents for sarcomas. Different abnormalities in sarcoma could be divided by tumor subtype or by the molecular or pathway abnormality. However, some existing drugs or drugs in development may interfere with or alter more than one of the presented pathways. Keywords: sarcoma, targeted agents, tyrosine kinase inhibitors, mTor inhibition

  6. Hybrid superconducting a.c. current limiter extrapolation 63 kV-1 250 A

    Science.gov (United States)

    Tixador, P.; Levêque, J.; Brunet, Y.; Pham, V. D.

    1994-04-01

    (150 V/50 A) a permis de valider expérimentalement cette conception. Nous aborderons l'extrapolation d'un limiteur de taille industrielle (63 kV/1 250 A). Les résultats seront comparés à des limiteurs supraconducteurs résistifs et de type DASC.

  7. Biometric Calculation and Refractive Results. A Study of 250 Cases of Patients Operated for Cataract

    Directory of Open Access Journals (Sweden)

    Inés Benita Zamora Galindo

    2012-02-01

    Full Text Available Fundamento: el implante de lentes intraoculares en la cirugía de catarata significa un avance en la corrección refractiva de la afaquia. Pero sin el estudio previo a la cirugía y el correcto cálculo de la lente intraocular, los resultados no serían satisfactorios. Objetivo: evaluar el cálculo biométrico y la refracción posquirúrgica de pacientes operados de cataratas. Metodos: estudio descriptivo realizado en el Centro de Oftalmología del Estado de Anzoátegui, Venezuela, que incluyó 250 pacientes sometidos a cirugía de catarata, a quienes previamente se les realizó refracción, queratometría, biometría y cálculo de lente intraocular. Después de la cirugía se determinó: refracción esperada por el cálculo biométrico, error refractivo posoperatorio, agudeza visual posquirúrgica sin corrección y con corrección. Resultados: predominó el sexo femenino y el grupo de edad entre 60 y 69 años. El valor más registrado de la queratometría  osciló de 43 a 44 dioptrías. El valor de la longitud axial más destacado fue de 22 a 24 mm. Las lentes intraoculares más usadas fueron de 16 a 20 dioptrías y las de 21 a 25 dioptrías. El mayor por ciento de la refracción esperada estuvo en el grupo de 0,00 a 0, 50. El error refractivo que predominó fue el de 0,50 a 1,00. En la refracción realizada al mes de la cirugía, sin cristales, más de la mitad de los pacientes obtuvo visiones entre 20/30 y 20/25. Conclusiones: se demostró la efectividad del cálculo de la lente intraocular previo a la cirugía de catarata.

  8. Interpreting 250m Moderate Resolution Imaging Spectroradiometer Vegetation Indices in the Colorado Plateau, USA

    Science.gov (United States)

    Hamar, M.; White, M.; Lauver, C.; Garman, S.

    2006-12-01

    Semi-arid ecosystems, which are inherently vulnerable to small changes in the amount and distribution of precipitation, are frequently co-located with extensive human habitations and vulnerable species distributions. Important societal considerations identified by GEOSS, such as human health and well-being, ecological services, environmental protection, genetic resources, and disaster risk reduction and mitigation, may be under particular strain from invasive species, demographic changes, and/or climate change in semi-arid ecosystems. Satellite-based remote sensing may therefore be an important tool for monitoring the status of semi-arid ecosystems and habitats. Yet to date, the ability of current generation sensors, such as the Moderate Resolution Imaging Spectroradiometer (MODIS), to accurately represent within-season phenological variability in semi-arid ecosystems a crucial precursor for long-term monitoring is largely unknown. Several programs worldwide seek information on this relationship. As part of one such effort, the Vital Signs Monitoring program for the National Park Service (NPS), we evaluated the ability of the MODIS 250m Normalized Difference Vegetation Index (NDVI), Enhanced Vegetation Index (EVI), and red, near infra-red, and blue channels to represent relative changes in ground-measured vegetation structure. Using an AccuPAR LP-80 PAR/LAI Ceptometer, LAI-2000 Plant Canopy Analyzer, and First Growth digital camera, we sampled plant area index (PAI) and green fractional cover (GFC) at 4 sites along a bioclimatic gradient in the Colorado Plateau, USA, representing semi-arid woodland, mixed grassland/shrubland, and grassland plant functional types. In 14 visits from June 2005 to October 2005, we intensively sampled each site at a spatial resolution directly comparable to 4 MODIS pixels. At each site, PAI was always less than 1.0 and often less than 0.4 and GFC was rarely greater than 5%. Likely due to low plant cover and instrument noise, correlation

  9. THE STUDY OF IMPROVING OF STABILITY AND RELIABILITY FOR 250kV HIGH VOLTAGE POWER%改进250kV高压电源稳定性与可靠性的研究

    Institute of Scientific and Technical Information of China (English)

    廖小东; 郑思孝; 刘仲阳; 孙官清; 王培录

    2001-01-01

    The hitches for a ppearing in the high voltage power at 250kV and improvement of the controlling circuit techniques are described. The static high voltage output was exercised by raising the high voltage gradually. The affects between the current load-variety and the vaviety of the input voltoge at + 1096 against the high voltage stability have been obtained. The experiments prove that the high voltage stability have been raised greatly via improving the controlling circuit.

  10. Low intensity beam target unit

    CERN Multimedia

    1976-01-01

    This is a wheel fitted with many targets around its periphery (each with three longitudinally arranged thin rods) of which one is placed into the beam via a rotation of the wheel. Upstream of each target is placed a luminescent screen, aligbed on each target axis and viewed with a TV camera, to make sure that one is hitting the target. This target unit was probably used to study target's behaviour (like beam heating). Gualtiero Del Torre stands on the left, Pierre Gerdil on the right.

  11. Does the Loss of ARID1A (BAF-250a Expression in Endometrial Clear Cell Carcinomas Have Any Clinicopathologic Significance? A Pilot Assessment

    Directory of Open Access Journals (Sweden)

    Oluwole Fadare, Idris L. Renshaw, Sharon X. Liang

    2012-01-01

    Full Text Available SWI/SNF chromatin-modification complexes use the energy of ATP hydrolysis to remodel nucleosomes and to affect transcription and several cellular processes. Accordingly, their loss of function has been associated with malignant transformation. ARID1A (the expression of whose product, BAF250a, a key complex component, is lost when mutated has recently been identified as a tumor suppressor gene that is mutated in 46-57% of ovarian clear cell carcinoma (CCC. The purposes of this study are to assess the frequency of loss of BAF250a expression in endometrial CCC and whether this loss has any discernable clinicopathologic implications. 34 endometrial carcinomas with a CCC component (including 22 pure CCC, 8 mixed carcinomas with a 10% CCC component, and 4 carcinosarcomas with a CCC epithelial component, were evaluated by immunohistochemistry using a monoclonal antibody directed against the human BAF250a protein. 5 (22.7% of the 22 pure CCC were entirely BAF250a negative, whereas the remainder showed diffuse immunoreactivity. None of 4 carcinosarcomas and only 1 (12.5% of the 8 mixed carcinomas were BAF250a negative. There was no discernable relationship between BAF250a immunoreactivity status and tumor architectural patterns (solid, papillary or tubulocystic areas or cell type (flat, hobnail or polygonal. Of the 22 patients with pure CCC, 14, 2, 3, and 3 were International Federation of Gynecology and Obstetrics stages 1, II, III and IV respectively. Interestingly, all 5 BAF250a negative cases were late stage [stages III or IV] as compared with 1 of 17 BAF250a positive cases (p=0.0002. Thus, 83% (5/6 of all late stage cases were BAF250a [-], as compared with 0 (0% of the 16 early stage (I or II cases (p=.0002. BAF250a negative and positive cases did not show any statistically significant difference regarding patient age and frequency of lymphovascular invasion or myometrial invasion. As may be anticipated from the concentration of late stage cases in

  12. Target Housing Material Options

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-02-11

    With gas cooling, heat transfer coefficients are low compared to water. The benefit of gas from a heat transfer point of view is that there is really no upper temperature limit for the coolant, as compared to water, which is limited ultimately by the critical point, and in practice the critical heat flux. In our case with parallel flow channels, water is limited to even lower operating limits by nucleate boiling. So gas can get as hot as the containment material will allow, but to get the density and heat transfer up to something reasonable, we must also increase pressure, thus increasing stress on the containment, namely the front and back faces. We are designing to ASME BPVC, which, for most materials allows a maximum stress of UTS/3. So we want the highest possible UTS. For reference, the front face stress in the 12 mm target at 300 psi was about 90 MPa. The inconel 718 allowable stress at 900°C is 1/3 of 517 or 172 MPa. So we are in a very safe place, but the uTS is dropping rapidly with temperature above 900°C. As we increase target diameter, the challenge will be to keep the stress down. We are probably looking at keeping the allowable at or above the present value, and at as high a temperature as possible.

  13. Determination of Recrystallization Temperature of Reverted Austenite of C-250 Maraging Steel%C-250马氏体时效钢逆变奥氏体再结晶温度的测定

    Institute of Scientific and Technical Information of China (English)

    赵飞; 秦路平; 魏志坚; 张华

    2011-01-01

    Based on the theory of phase transformation and recrystallization accompanied with thermal effect and volume effect, the austenization temperature and reverted austenite recrystallization temperature of C-250 maraging steel was determined by DSC and dilatometer.The austenization temperature is As ≈ 647 ℃ and Af≈ 780 ℃, while the recrystallization temperature of reverted austenite is 923.1 ℃.%利用相变过程和逆变再结晶过程伴随着热效应体积效应的原理,采用热分析和热膨胀相结合的方法来测定C-250马氏体时效钢的奥氏体化温度和逆变奥氏体再结晶温度.结果显示,C-250马氏体时效钢的奥氏体化温度为A≈647℃,A≈780℃,逆变奥氏体再结晶温度为923.1℃.

  14. Performance of 4 mm impact sprinklers at different spacing within acceptable pressure range (250-350 kPa

    Directory of Open Access Journals (Sweden)

    SOROPA GABRIEL,

    2011-03-01

    Full Text Available Single leg tests were conducted to determine performance and cost effectiveness of different spacing combinations that can be used in 4 mm impact sprinkler irrigation systems design operating at 250-350kPa. Four sprinklers were tested for coefficient of uniformity (CU, distribution uniformity (DU and wetted diameter at three different pressure points. Results obtained for CU and DU showed that imported sprinklers had significantly higher water application uniformities than locally made sprinklers at 250-350 kPa pressure range. Sprinkler spacings of 12 m x 18 m and 15 m x 15 m passed the layout tests and can be used in Zimbabwe under moderate wind conditions at 300 kPa, using preferably imported sprinklers for best water application uniformity. Therefore 15 m x 15 m sprinkler spacing which covers alarger area can replace 12 m x 18 m layout in spraylines design without compromising water application uniformity.

  15. 250 kV 6 mA compact Cockcroft-Walton high-voltage power supply

    Science.gov (United States)

    Ma, Zhan-Wen; Su, Xiao-Dong; Lu, Xiao-Long; Wei, Zhen; Wang, Jun-Run; Huang, Zhi-Wu; Miao, Tian-You; Su, Tong-Ling; Yao, Ze-En

    2016-08-01

    A compact power supply system for a compact neutron generator has been developed. A 4-stage symmetrical Cockcroft-Walton circuit is adopted to produce 250 kV direct current high-voltage. A 2-stage 280 kV isolation transformer system is used to drive the ion source power supply. For a compact structure, safety, and reliability during the operation, the Cockcroft-Walton circuit and the isolation transformer system are enclosed in an epoxy vessel containing the transformer oil whose size is about ∅350 mm × 766 mm. Test results indicate that the maximum output voltage of the power supply is 282 kV, and the stability of the output voltage is better than 0.63% when the high voltage power supply is operated at 250 kV, 6.9 mA with the input voltage varying ±10%.

  16. 250 kV 6 mA compact Cockcroft-Walton high-voltage power supply.

    Science.gov (United States)

    Ma, Zhan-Wen; Su, Xiao-Dong; Lu, Xiao-Long; Wei, Zhen; Wang, Jun-Run; Huang, Zhi-Wu; Miao, Tian-You; Su, Tong-Ling; Yao, Ze-En

    2016-08-01

    A compact power supply system for a compact neutron generator has been developed. A 4-stage symmetrical Cockcroft-Walton circuit is adopted to produce 250 kV direct current high-voltage. A 2-stage 280 kV isolation transformer system is used to drive the ion source power supply. For a compact structure, safety, and reliability during the operation, the Cockcroft-Walton circuit and the isolation transformer system are enclosed in an epoxy vessel containing the transformer oil whose size is about ∅350 mm × 766 mm. Test results indicate that the maximum output voltage of the power supply is 282 kV, and the stability of the output voltage is better than 0.63% when the high voltage power supply is operated at 250 kV, 6.9 mA with the input voltage varying ±10%.

  17. 250 kV 6 mA compact Cockcroft-Walton high-voltage power supply.

    Science.gov (United States)

    Ma, Zhan-Wen; Su, Xiao-Dong; Lu, Xiao-Long; Wei, Zhen; Wang, Jun-Run; Huang, Zhi-Wu; Miao, Tian-You; Su, Tong-Ling; Yao, Ze-En

    2016-08-01

    A compact power supply system for a compact neutron generator has been developed. A 4-stage symmetrical Cockcroft-Walton circuit is adopted to produce 250 kV direct current high-voltage. A 2-stage 280 kV isolation transformer system is used to drive the ion source power supply. For a compact structure, safety, and reliability during the operation, the Cockcroft-Walton circuit and the isolation transformer system are enclosed in an epoxy vessel containing the transformer oil whose size is about ∅350 mm × 766 mm. Test results indicate that the maximum output voltage of the power supply is 282 kV, and the stability of the output voltage is better than 0.63% when the high voltage power supply is operated at 250 kV, 6.9 mA with the input voltage varying ±10%. PMID:27587170

  18. A Note on Inflation Targeting.

    Science.gov (United States)

    Lai, Ching-chong; Chang, Juin-jen

    2001-01-01

    Presents a pedagogical graphical exposition to illustrate the stabilizing effect of price target zones. Finds that authorities' commitment to defend a price target zone affects the public's inflation expectations and, in turn, reduces actual inflation. (RLH)

  19. Experimental '' of As at 170, 200, 250 and 300 K from the Bijvoet pairs of GaAs

    Indian Academy of Sciences (India)

    G Raja Sudha; K Vimala Devi; D Arthi; S Prasanna Subramanian; N Srinivasan; R Saravanan

    2002-08-01

    Anomalous dispersion effects lead to the modification of the measured X-ray structure factors. In this work, we have determined the imaginary part of the anomalous dispersion correction terms ('' ) of arsenide atom (As), through the X-ray data collected using spherical single crystal of GaAs, at various temperatures, i.e. 170, 200, 250 and 300 K. It is stressed that more measurements of '' of the elements are needed to confirm the theoretical calculations.

  20. Complete Set of Deuteron Analyzing Powers for dp Elastic Scattering at 250 MeV/nucleon and Three Nucleon Forces

    Directory of Open Access Journals (Sweden)

    Shimizu Y.

    2010-04-01

    Full Text Available Measurements of a complete set of deuteron analyzing powers (iT11, T20, T21, T22 for elastic deuteron–proton scattering at 250 MeV/nucleon have been performed with polarized deuteron beams at RIKEN RI Beam Factory. The obtained data are compared with the Faddeev calculations based on the modern nucleon–nucleon forces together with the Tucson-Melbourne’99, and UrbanaIX three nucleon forces.

  1. Digital standard cells and operational amplifiers for operation up to 250 degrees C using low-cost CMOS technology

    Science.gov (United States)

    Stemmer, Jens; Ackermann, Joerg; Uffmann, Dirk; Aderhold, Jochen

    1996-09-01

    There is an increasing demand from automotive, aircraft and space industry for reliable high temperature resistant electronics. Circuits with reliable functionality up to temperatures of 250 degree(s)C would be sufficient for most of these applications. Digital standard cells and operational amplifiers are the basic building blocks of these circuits. Commercially available digital standard cell libraries and operational amplifiers are normally specified for operation up to a maximum temperature of 125 degree(s)C. Hence, the purpose of this work was the design and characterization of digital standard cells and operational amplifiers for operation up to 250 degree(s)C using a low-cost 1.0 micrometers epi-CMOS process. Several design measures were applied to the cells in order to further improve latch-up resistivity and to limit leakage currents, respectively. The transfer curves of all digital cells for all input signal combinations have been recorded in the temperature range from 30 to 250 degree(s)C. Significant results are very low temperature shifts of the noise margins and of the switching point, respectively. Furthermore, the low (0 V) and high (5 V) levels are reached exactly over the entire temperature range. Outstanding characteristics of the operational amplifier comprise low open-loop gain temperature drift as well as low offset and offset temperature drift, respectively. The open-loop gain was greater than 83 dB at room temperature with a drift of less than 0.02 dB/ degree(s)C. The offset voltage amounted to -1 mV at room temperature and 1 mV at 250 degree(s)C, respectively. The long-term behavior of these cells is currently under investigation.

  2. Phenotypic expression of the fibroblast growth factor receptor 3 (FGFR3) mutation P250R in a large craniosynostosis family.

    OpenAIRE

    Golla, A; Lichmer, P; von Gernet, S; Winterpacht, A; Fairley, J.; Murken, J.; Schuffenhauer, S.

    1997-01-01

    The craniosynostosis syndromes are a heterogeneous group of sporadic, autosomal dominant disorders with significant clinical overlap. Recently, we described a large family with autosomal dominant craniosynostosis suggestive of Saethre-Chotzen syndrome, in which linkage to the Saethre-Chotzen syndrome loci on 7p had been excluded. We now report the presence of a mutation in the fibroblast growth factor receptor 3 (FGFR3) in this family. The mutation, P250R, had been previously reported in 10 p...

  3. Downscaling 250-m MODIS Growing Season NDVI Based on Multiple-Date Landsat Images and Data Mining Approaches

    OpenAIRE

    Yingxin Gu; Bruce K. Wylie

    2015-01-01

    The satellite-derived growing season time-integrated Normalized Difference Vegetation Index (GSN) has been used as a proxy for vegetation biomass productivity. The 250-m GSN data estimated from the Moderate Resolution Imaging Spectroradiometer (MODIS) sensors have been used for terrestrial ecosystem modeling and monitoring. High temporal resolution with a wide range of wavelengths make the MODIS land surface products robust and reliable. The long-term 30-m Landsat data provide spatial detaile...

  4. Some Issues in Inflation Targeting

    OpenAIRE

    Andrew Haldane

    1997-01-01

    This paper discusses some of the operational issues relevant to the implementation of an inflation-targeting regime. In particular it focuses on: whether inflation targeting is 'new'; whether (and how) the forward-looking nature of inflation-targeting helps to prevent instabilities in inflation; whether inflation-targeting potentially destabilises output; and whether it requires too much knowledge on the part of the authorities. The paper argues that none of these propositions is in general c...

  5. 30 CFR 250.465 - When must I submit an Application for Permit to Modify (APM) or an End of Operations Report to MMS?

    Science.gov (United States)

    2010-07-01

    ... MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Modify and Well Records § 250.465... of § 250.412. (3) Move a drilling unit from a wellbore before completing a well Submit forms...

  6. MODIS/TERRA MOD44W Land Water Mask Derived from MODIS and SRTM L3 Global 250m SIN Grid

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Land Water Mask Derived from MODIS and SRTM L3 Global 250m SIN Grid MOD44W The new MODIS 250 m land-water mask (Short Name: MOD44W) is an improvement over the...

  7. 30 CFR 250.1156 - What steps must I take to receive approval to produce within 500 feet of a unit or lease line?

    Science.gov (United States)

    2010-07-01

    ... produce within 500 feet of a unit or lease line? 250.1156 Section 250.1156 Mineral Resources MINERALS... I take to receive approval to produce within 500 feet of a unit or lease line? (a) You must obtain... any portion of the completed interval less than 500 feet from a unit or lease line. Submit to MMS...

  8. 12 CFR 250.220 - Whether member bank acting as trustee is prohibited by section 20 of the Banking Act of 1933 from...

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Whether member bank acting as trustee is prohibited by section 20 of the Banking Act of 1933 from acquiring majority of shares of mutual fund. 250.220 Section 250.220 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE...

  9. 12 CFR 250.408 - Short-term negotiable notes of banks not securities under section 32, Banking Act of 1933.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Short-term negotiable notes of banks not securities under section 32, Banking Act of 1933. 250.408 Section 250.408 Banks and Banking FEDERAL RESERVE... securities under section 32, Banking Act of 1933. (a) The Board of Governors has been asked whether...

  10. ORION laser target diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Bentley, C. D.; Edwards, R. D.; Andrew, J. E.; James, S. F.; Gardner, M. D.; Comley, A. J.; Vaughan, K.; Horsfield, C. J.; Rubery, M. S.; Rothman, S. D.; Daykin, S.; Masoero, S. J.; Palmer, J. B.; Meadowcroft, A. L.; Williams, B. M.; Gumbrell, E. T.; Fyrth, J. D.; Brown, C. R. D.; Hill, M. P.; Oades, K. [Plasma Physics Department, Atomic Weapons Establishment, Aldermaston, Reading, Berkshire RG7 4PR (United Kingdom); and others

    2012-10-15

    The ORION laser facility is one of the UK's premier laser facilities which became operational at AWE in 2010. Its primary mission is one of stockpile stewardship, ORION will extend the UK's experimental plasma physics capability to the high temperature, high density regime relevant to Atomic Weapons Establishment's (AWE) program. The ORION laser combines ten laser beams operating in the ns regime with two sub ps short pulse chirped pulse amplification beams. This gives the UK a unique combined long pulse/short pulse laser capability which is not only available to AWE personnel but also gives access to our international partners and visiting UK academia. The ORION laser facility is equipped with a comprehensive suite of some 45 diagnostics covering optical, particle, and x-ray diagnostics all able to image the laser target interaction point. This paper focuses on a small selection of these diagnostics.

  11. Electromagnetic targeting of guns

    Energy Technology Data Exchange (ETDEWEB)

    Pogue, E.W.; Boat, R.M.; Holden, D.N.; Lopez, J.R. [and others

    1996-10-01

    This is the final report of a one-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). Electromagnetic pulse (EMP) signals produced from explosives being fired have been reported in the literature for fifty years. When a gun is fired it produces an EMP muzzle blast signal. The strength and nature of these signals was first analyzed in the early 1970s, while the results were interesting, no follow-up studies were conducted. With modern detection and signal processing technology, we believe that these signals could be used to instantaneously locate guns of virtually all calibers as they fire. The objective of our one-year project was to establish the basic nature of these signals and their utility in the concept of electromagnetic targeting of guns.

  12. ORION laser target diagnosticsa)

    Science.gov (United States)

    Bentley, C. D.; Edwards, R. D.; Andrew, J. E.; James, S. F.; Gardner, M. D.; Comley, A. J.; Vaughan, K.; Horsfield, C. J.; Rubery, M. S.; Rothman, S. D.; Daykin, S.; Masoero, S. J.; Palmer, J. B.; Meadowcroft, A. L.; Williams, B. M.; Gumbrell, E. T.; Fyrth, J. D.; Brown, C. R. D.; Hill, M. P.; Oades, K.; Wright, M. J.; Hood, B. A.; Kemshall, P.

    2012-10-01

    The ORION laser facility is one of the UK's premier laser facilities which became operational at AWE in 2010. Its primary mission is one of stockpile stewardship, ORION will extend the UK's experimental plasma physics capability to the high temperature, high density regime relevant to Atomic Weapons Establishment's (AWE) program. The ORION laser combines ten laser beams operating in the ns regime with two sub ps short pulse chirped pulse amplification beams. This gives the UK a unique combined long pulse/short pulse laser capability which is not only available to AWE personnel but also gives access to our international partners and visiting UK academia. The ORION laser facility is equipped with a comprehensive suite of some 45 diagnostics covering optical, particle, and x-ray diagnostics all able to image the laser target interaction point. This paper focuses on a small selection of these diagnostics.

  13. ORION laser target diagnostics.

    Science.gov (United States)

    Bentley, C D; Edwards, R D; Andrew, J E; James, S F; Gardner, M D; Comley, A J; Vaughan, K; Horsfield, C J; Rubery, M S; Rothman, S D; Daykin, S; Masoero, S J; Palmer, J B; Meadowcroft, A L; Williams, B M; Gumbrell, E T; Fyrth, J D; Brown, C R D; Hill, M P; Oades, K; Wright, M J; Hood, B A; Kemshall, P

    2012-10-01

    The ORION laser facility is one of the UK's premier laser facilities which became operational at AWE in 2010. Its primary mission is one of stockpile stewardship, ORION will extend the UK's experimental plasma physics capability to the high temperature, high density regime relevant to Atomic Weapons Establishment's (AWE) program. The ORION laser combines ten laser beams operating in the ns regime with two sub ps short pulse chirped pulse amplification beams. This gives the UK a unique combined long pulse/short pulse laser capability which is not only available to AWE personnel but also gives access to our international partners and visiting UK academia. The ORION laser facility is equipped with a comprehensive suite of some 45 diagnostics covering optical, particle, and x-ray diagnostics all able to image the laser target interaction point. This paper focuses on a small selection of these diagnostics. PMID:23126904

  14. Late radiation fibrosis in rat lung following protons and 250 kV X-rays irradiation

    International Nuclear Information System (INIS)

    To investigate the biological effectiveness of proton beams in the development of pulmonary fibrosis the lungs of male 7-week-old Wistar rats were locally irradiated with a single dose of 10-50 Gy of 250 kV X-rays and modulated, 250 MeV protons at Particle Radiation Medical Science Center (PARMS). Animals were sacrificed serially after 3, 6, 9, and 12 months at which times the development of the fibrotic lesion in alveolar walls and peribonchial connective tissues was assessed quantitatively by analysis of microscopic image of Azan-Mallory stained sections. Fibrosis index (FI) values in alveolar walls and peribronchial tissues were defined as the fraction (in percent) of a specific image area, the gray level of which represents collagen deposits. Using this FI values, the increase of fibrotic lesion following 0-40 Gy of X-rays irradiation as a function of time were observed better in alveolar walls than in peribronchial tissues. Compared with 250 kV X-rays, 30 Gy of proton beams irradiation produced less increase in the time course of FI values of alveolar walls and dose-response curve at 12 months later suggested that the fibrotic lesion in alveolar walls after protons exposure to the doses above 30 Gy might develop more slowly. (author) 51 refs

  15. Targeting of Antibodies using Aptamers

    OpenAIRE

    Missailidis, Sotiris

    2003-01-01

    The chapter presents a methodology for the rapid selection of aptamers against antibody targets. It is a detailed account of the various methodological steps that describe the selection of aptamers, including PCR steps, buffers to be used, target immobilisation, partitioning and amplification of aptamers, clonning and sequencing, to results in high affinity and specificity ligands for the chosen target antibody.

  16. After treat-to-target

    DEFF Research Database (Denmark)

    Wakefield, Richard J; D'Agostino, Maria Antonietta; Naredo, Esperanza;

    2012-01-01

    rheumatologists who have recently formed a research network - the Targeted Ultrasound Initiative (TUI) group. The statement proposes that targeting therapy to PD activity provides superior outcomes compared with treating to clinical targets alone and introduces the rationale for a new randomised trial using...

  17. The G-250A polymorphism in the hepatic lipase gene promoter is associated with changes in hepatic lipase activity and LDL cholesterol: The KANWU Study

    DEFF Research Database (Denmark)

    Lindi, Virpi; Schwab, Ursula; Louheranta, Anne;

    2007-01-01

    acids (SFA diet) or monounsaturated fatty acids (MUFA diet). Within groups there was a second random assignment to supplements with fish oil (3.6g n-3 FA/day) or placebo. At baseline, the A-250A genotype was associated with high serum LDL cholesterol concentration (P=0.030 among three genotypes......). On the MUFA diet carriers of the A-250A genotype presented a greater decrease in LDL cholesterol concentration than subjects with other genotypes (P=0.007 among three genotypes). The rare -250A allele was related to low HL activity (P... activity among the genotypes. CONCLUSION: The A-250A genotype of the LIPC gene was associated with high LDL cholesterol concentration, but the MUFA-enriched diet reduced serum LDL cholesterol concentration especially in subjects with the A-250A genotype. Udgivelsesdato: 2008-Feb...

  18. Cryogenic polarized target facility. Final report, July 1, 1980-September 30, 1984

    International Nuclear Information System (INIS)

    We have constructed at the Triangle Universities Nuclear Laboratory a cryogenic polarized target facility for the brute force nuclear orientation of bulk metallic samples. The target facility was developed in conjunction with a polarized neutron beam facility at TUNL and is presently being used to study spin-spin effects in total neutron cross sections for polarized neutrons incident on polarized nuclei. The goals of the program have been to demonstrate the feasibility of using present cryogenic technology to produce different polarized targets, and to perform initial measurements of spin-spin cross sections. A 16.2 cm3 sample of 27Al has been cooled to 11.3 mK in a magnetic field of 6.9 T, giving a target polarization of 36%. Preliminary measurements with 46% longitudinally polarized neutrons of energy 14 MeV have yielded a spin-spin cross section of 130 +- 60 mb (< 250 mb to two standard deviations)

  19. Should the dose of tenofovir be reduced to 200–250 mg/day, when combined with protease inhibitors?

    Directory of Open Access Journals (Sweden)

    Andrew Hill

    2014-11-01

    Full Text Available Introduction: The approved dose of tenofovir disproxil fumarate, 300 mg once daily, was established in clinical trials in combination with efavirenz, which does not significantly affect tenofovir concentrations. Combining tenofovir with lopinavir/r, darunavir/r or atazanavir/r increases tenofovir concentrations, which could raise the risk of renal adverse events. Newly approved tenofovir tablets are available at lower strength (200 or 250 mg for use in paediatrics. Methods: A literature search was used to assess the effects of lopinavir/r, darunavir/r and atazanavir/r on tenofovir plasma Cmax, AUC and Cmin (Geometric Mean Ratio and 90% confidence intervals. Assuming linear dose-proportional pharmacokinetics (as observed in dose-ranging studies, the 250 mg tablet was predicted to achieve plasma concentrations 17% lower than the 300 mg dose, and the 200 mg tablet to achieve plasma levels 33% lower. Effects on tenofovir plasma Cmax, AUC and Cmin concentrations were assessed for combined dosing of each protease inhibitor with 250 or 200 mg daily doses of tenofovir, versus standard dose tenofovir (300 mg daily without protease inhibitors. Results: In drug-drug interaction studies, lopinavir/ritonavir significantly increased tenofovir Cmax, AUC and Cmin. Effects of each PI on tenofovir Cmin were greater than effects on Cmax or AUC. Using a 250 mg paediatric dose of tenofovir with lopinavir/ritonavir, tenofovir Cmin was predicted to remain higher than tenofovir 300 mg used with efavirenz (GMR=1.26, 95% CI 1.14–1.38. Similar results were observed for use of tenofovir 250 mg with atazanavir/ritonavir (GMR=1.07, 95% CI 1.01–1.13 and with darunavir/ritonavir (GMR=1.14, 95% CI 0.99–1.31. Predicted tenofovir AUC levels for the 250 mg dose with protease inhibitors were all within the bioequivalence range, relative to use with efavirenz. Using a 200 mg paediatric dose of tenofovir with lopinavir/ritonavir, the tenofovir Cmin was predicted to be

  20. Hypoxia targeting copper complexes

    International Nuclear Information System (INIS)

    The importance and incidence of tumour hypoxia, its measurement and current treatments available, including pharmacological and radiopharmacological methods of targeting hypoxia, are discussed. A variety of in vitro and in vivo methods for imposing hypoxia have been developed and are reviewed. Copper, its chemistry, biochemistry and radiochemistry, the potential for use of copper radionuclides and its use to date in this field is considered with particular reference to the thiosemicarbazones. Their biological activity, metal chelation, in vitro and in vivo studies of their radiocopper complexes and the potential for their use as hypoxia targeting radiopharmaceuticals is described. The reduction of the copper(II) complex to copper(l), its pivotal importance in their biological behaviour, and the potential for manipulation of this to effect hypoxia selectivity are described. An in vitro method for assessing the hypoxia selectivity of radiopharmaceuticals is reported. The rapid deoxygenation and high viability of a mammalian cell culture in this system is discussed and factors which may affect the cellular uptake of a radiopharmaceutical are described. The design, synthesis and complexation with copper and radiocopper of a range of bis(thiosemicarbazones) is reported. Synthesis of these compounds is simple giving high yields of pure products. The characteristics of the radiocopper complexes (64Cu) including lipophilicity and redox activity are reported (reduction potentials in the range -0.314 - -0.590 V). High cellular uptakes of the radiocopper complexes of the ligands, in hypoxic and normoxic EMT6 and CHO320 cells, were observed. Extremes of selectivity are shown ranging from the hypoxia selective 64Cu(II)ATSM to normoxic cell selective 64Cu(II)GTS. The selectivities observed are compared with the physico chemical characteristics of the complexes. A good correlation exists between selectivity of the complex and its Cu(II)/Cu(I) reduction potential, with hypoxia