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Sample records for calculus bovis compound

  1. Study on bioactive compounds of in vitro cultured Calculus Suis and natural Calculus Bovis.

    Science.gov (United States)

    Wan, Tien-Chun; Cheng, Fu-Yuan; Liu, Yu-Tse; Lin, Liang-Chuan; Sakata, Ryoichi

    2009-12-01

    The purpose of the study was to investigate bioactive compounds of in vitro cultured Calculus Suis and natural Calculus Bovis obtained as valuable by-products from animals used for meat production. The results showed that the components of natural Calculus Bovis were rich in bilirubin and biliverdin and had higher content of essential amino acids. The major amino acids of in vitro cultured Calculus Suis were identified as glycine, alanine, glutamic acid and aspartic acid, and those for natural Calculus Bovis were found to be glutamic acid, aspartic acid, proline, and arginine. The methionine and cysteine contents of precursors for glutathione in natural Calculus Bovis were significantly higher than those of in vitro cultured Calculus Suis. The mineral contents of zinc, iron and manganese of natural Calculus Bovis were significantly higher than those of in vitro cultured Calculus Suis. The major bile acids in both products were cholic acid and dehydrocholic acid, respectively. The chenodeoxycholic and ursodeoxycholic acid content of in vitro cultured Calculus Suis was significantly higher than that of natural Calculus Bovis.

  2. Effects of in vitro cultivated Calculus Bovis compound on pulmonary lesions in rabbits with schistosomiasis.

    Science.gov (United States)

    Li, Tao; Yang, Zhen; Cai, Hong-Jiao; Song, Li-Wei; Lu, Ke-Yu; Zhou, Zheng; Wu, Zai-De

    2010-02-14

    To explore the interventional effects and mechanism of in vitro cultivated Calculus Bovis compound preparation (ICCBco) on pulmonary lesions in portal hypertensive rabbits with schistosomiasis. The experimental group included 20 portal hypertensive rabbits with schistosomiasis treated by ICCBco. The control group included 20 portal hypertensive rabbits with schistosomiasis treated by praziquantel. The morphological changes of the pulmonary tissues were observed under light and electron microscopy. The expression of fibronectin (FN) and laminin (LN) in the lung tissues was analyzed by immunohistochemistry. Under light microscope, the alveolar exudation in the lung tissue was more frequently observed in the control group, while the alveolar space was fairly dry in the lung tissue of ICCBco group. Under electron microscope, more alveolar exudation in the lung tissue, and more macrophages, alveolar angiotelectasis and the blurred three-tier structure of alveolar-capillary barrier could be seen in the control group. In ICCBco group, fibers within the alveolar interspace slightly increased in some lung regions, and the structure of type I epithelium, basement membrane and endodermis was complete, and no obvious exudation from the alveolar space, and novascular congestion could be observed. There was a positive or strong positive expression of FN and LN in the lung tissue of the control group, while there was a negative or weak positive expression of FN and LN in ICCBco group. ICCBco can effectively prevent pulmonary complications in portal hypertensive rabbits with schistosomiasis by means of improving lung microcirculation and lowering the content of extracellular matrix.

  3. Comparative study on major bioactive components in natural, artificial and in-vitro cultured Calculus Bovis.

    Science.gov (United States)

    Yan, Shi-Kai; Wu, Yan-Wen; Liu, Run-Hui; Zhang, Wei-Dong

    2007-01-01

    Major bioactive components in various Calculus Bovis, including natural, artificial and in-vitro cultured Calculus Bovis, were comparatively studied. An approach of high-performance liquid chromatography coupled with ultraviolet and evaporative light scattering detections (HPLC/UV/ELSD) was established to simultaneously determinate six bioactive components thereof, including five bile acids (cholic acid, deoxycholic acid, ursodeoxycholic, chenodeoxycholic acid, hyodeoxycholic acid) and bilirubin. ELSD and UV detector were applied to detect bile acids and bilirubin respectively. The assay was performed on a C(18) column with water-acetonitrile gradient elution and the investigated constituents were authenticated by comparing retention times and mass spectra with those of reference compounds. The proposed method was applied to analyze twenty-one Calculus Bovis extraction samples, and produced data with acceptable linearity, precision, repeatability and accuracy. The result indicated the variations among Calculus Bovis samples under different developmental conditions. Artificial and in-vitro cultured Calculus Bovis, especially in-vitro cultured ones, which contain total bioactive constituents no less than natural products and have the best batch-to-batch uniformity, suffice to be used as substitutes of natural Calculus Bovis.

  4. [Single and combining effects of Calculus Bovis and zolpidem on inhibitive neurotransmitter of rat striatum corpora].

    Science.gov (United States)

    Liu, Ping; He, Xinrong; Guo, Mei

    2010-04-01

    To investigate the correlation effects between single or combined administration of Calculus Bovis or zolpidem and changes of inhibitive neurotransmitter in rat striatum corpora. Sampling from rat striatum corpora was carried out through microdialysis. The content of two inhibitive neurotransmitters in rat corpus striatum- glycine (Gly) and gama aminobutyric acid (GABA), was determined by HPLC, which involved pre-column derivation with orthophthaladehyde, reversed-phase gradient elution and fluorescence detection. GABA content of rat striatum corpora in Calculus Bovis group was significantly increased compared with saline group (P Calculus Boris plus zolpidem group were increased largely compared with saline group as well (P Calculus Bovis group was higher than combination group (P Calculus Bovis or zolpidem group was markedly increased compared with saline group or combination group (P Calculus Bovis group, zolpidem group and combination group. The magnitude of increase was lower in combination group than in Calculus Bovis group and Zolpidem group, suggesting that Calculus Bovis promoted encephalon inhibition is more powerful than zolpidem. The increase in two inhibitive neurotransmitters did not show reinforcing effect in combination group, suggesting that Calculus Bovis and zolpidem may compete the same receptors. Therefore, combination of Calculus Bovis containing drugs and zolpidem has no clinical significance. Calculus Bovis shouldn't as an aperture-opening drugs be used for resuscitation therapy.

  5. Eye Irritation Test of Bovis Calculus Pharmacopuncture Solutions for Eye Drop

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    Hyeong-sik Seo

    2008-06-01

    Full Text Available Objective : This study was done to investigate the safety of Bovis Calculus pharmacopuncture solution manufactured with freezing dryness method to use eye drop. Methods : The eye irritation test of this material was performed according to the Regulation of Korea Food & Drug Administration (2005. 10. 21, KFDA 2005-60. After Bovis Calculus pharmacopuncture solution was medicated in the left eye of the rabbits, the auther observed eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Results : 1. After Bovis Calculus pharmacopuncture solution was medicated in the left eye of the rabbits, there wasn’t physical problem at 9 rabbits. 2. After Bovis Calculus pharmacopuncture solutionwas medicated in the left eye of the rabbits, there wasn’t eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Conclusions : I suggested that Bovis Calculus pharmacopuncture solution didn’t induced eye irritation in rabbits.

  6. The Experimental Study of Safety and Efficacy in Using Bovis Calculus Pharmacopuncture Solution as Eye Drop

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    Hyeongsik Seo

    2009-09-01

    Full Text Available Objectives : This experimental study was performed to investigate the safety and efficacy of Bovis Calculus pharmacopuncture solution manufactured with freezing dryness method to use eye drop. To identify the use of it as eye drop, the eye irritation test of rabbits and the antibacterial test of Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Aspergillus niger, Fusarium oxysporum, and Candida albicans were performed. Methods : 1. The eye irritation test of this material was performed according to the Regulation of Korea Food & Drug Administration(2005. 10. 21, KFDA 2005-60. After Bovis Calculus pharmacopuncture solution was administered in the left eye of the rabbits, eye irritation of the cornea, iris and conjunctiva was observed at 1, 2, 3, 4 & 7day. 2. After administering Bovis Calculus pharmacopuncture solution on bacterial species(Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Aspergillus niger, Fusarium oxysporum, Candida albicans which cause Keratitis, MIC(Minimum Inhibition Concentration and the size of inhibition zone were measured. Anti-bacterial potency was also measured using the size of inhibition zone. Results : 1. After Bovis Calculus pharmacopuncture solution was administered in the left eye of the rabbits, it was found that none of nine rabbits have abnormal signs and weight changes. 2. After Bovis Calculus pharmacopuncture solution was medicated in the left eye of the rabbits, no eye irritation of the cornea, iris and conjunctiva was observed at 1, 2, 3, 4 & 7day. 3. There was no response to MIC on bacterial species (Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Aspergillus niger, Fusarium oxysporum, Candida albicans after Bovis Calculus pharmacopuncture solution was medicated. Conclusions : The present study suggests that Bovis Calculus pharmacopuncture solution is a nontoxic and non-irritant medicine, which does not cause eye irritation in

  7. Searching for the main anti-bacterial components in artificial Calculus bovis using UPLC and microcalorimetry coupled with multi-linear regression analysis.

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    Zang, Qing-Ce; Wang, Jia-Bo; Kong, Wei-Jun; Jin, Cheng; Ma, Zhi-Jie; Chen, Jing; Gong, Qian-Feng; Xiao, Xiao-He

    2011-12-01

    The fingerprints of artificial Calculus bovis extracts from different solvents were established by ultra-performance liquid chromatography (UPLC) and the anti-bacterial activities of artificial C. bovis extracts on Staphylococcus aureus (S. aureus) growth were studied by microcalorimetry. The UPLC fingerprints were evaluated using hierarchical clustering analysis. Some quantitative parameters obtained from the thermogenic curves of S. aureus growth affected by artificial C. bovis extracts were analyzed using principal component analysis. The spectrum-effect relationships between UPLC fingerprints and anti-bacterial activities were investigated using multi-linear regression analysis. The results showed that peak 1 (taurocholate sodium), peak 3 (unknown compound), peak 4 (cholic acid), and peak 6 (chenodeoxycholic acid) are more significant than the other peaks with the standard parameter estimate 0.453, -0.166, 0.749, 0.025, respectively. So, compounds cholic acid, taurocholate sodium, and chenodeoxycholic acid might be the major anti-bacterial components in artificial C. bovis. Altogether, this work provides a general model of the combination of UPLC chromatography and anti-bacterial effect to study the spectrum-effect relationships of artificial C. bovis extracts, which can be used to discover the main anti-bacterial components in artificial C. bovis or other Chinese herbal medicines with anti-bacterial effects. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Determination of multicomponent contents in Calculus bovis by ultra-performance liquid chromatography-evaporative light scattering detection and its application for quality control.

    Science.gov (United States)

    Kong, Weijun; Jin, Cheng; Xiao, Xiaohe; Zhao, Yanling; Liu, Wei; Li, Zulun; Zhang, Ping

    2010-06-01

    A fast ultra-performance liquid chromatography-evaporative light scattering detection (UPLC-ELSD) method was established for simultaneous quantification of seven components in natural Calculus bovis (C. bovis) and its substitutes or spurious breeds. On a Waters Acquity UPLC BEH C(18) column, seven analytes were efficiently separated using 0.2% aqueous formic acid-acetonitrile as the mobile phase in a gradient program. The evaporator tube temperature of ELSD was set at 100 degrees C with the nebulizing gas flow-rate of 1.9 L/min. The results showed that this established UPLC-ELSD method was validated to be sensitive, precise and accurate with the LODs of seven analytes at 2-11 ng, and the overall intra-day and inter-day variations less than 3.0%. The recovery of the method was in the range of 97.8-101.6%, with RSD less than 3.0%. Further results of PCA on the contents of seven investigated analytes suggested that compounds of cholic acid, deoxycholic acid and chenodeoxycholic acid or cholesterol should be added as chemical markers to UPLC analysis of C. bovis samples for quality control and to discriminate natural C. bovis sample and its substitutes or some spurious breeds, then normalize the use of natural C. bovis and ensure its clinical efficacy.

  9. [Simultaneous determination of seven residual solvents in bovis calculus artifactus by headspace gas chromatography].

    Science.gov (United States)

    Chi, Shuyao; Wu, Dike; Sun, Jinhong; Ye, Ruhan; Wang, Xiaoyan

    2014-05-01

    A headspace gas chromatography (HS-GC) method was developed for the simultaneous determination of seven residual solvents (petroleum ether (60-90 degrees C), acetone, ethyl acetate, methanol, methylene chloride, ethanol and butyl acetate) in bovis calculus artifactus. The DB-WAX capillary column and flame ionization detector (FID) were used for the separation and detection of the residual solvents, and the internal standard method was used for the quantification. The chromatographic conditions, such as equilibrium temperature and equilibrium time, were optimized. Under the optimized conditions, all of the seven residual solvents showed good linear relationships with good correlation coefficients (not less than 0.999 3) in the prescribed concentration range. At three spiked levels, the recoveries for the seven residual solvents were 94.7%-105.2% with the relative standard deviations (RSDs) less than 3.5%. The limits of detection (LODs) of the method were 0.43-5.23 mg/L, and the limits of quantification (LOQs) were 1.25-16.67 mg/L. The method is simple, rapid, sensitive and accurate, and is suitable for the simultaneous determination of the seven residual solvents in bovis calculus artifactus.

  10. Simultaneous quantification of the major bile acids in artificial Calculus bovis by high-performance liquid chromatography with precolumn derivatization and its application in quality control.

    Science.gov (United States)

    Shi, Yan; Xiong, Jing; Sun, Dongmei; Liu, Wei; Wei, Feng; Ma, Shuangcheng; Lin, Ruichao

    2015-08-01

    An accurate and sensitive high-performance liquid chromatography method coupled with ultralviolet detection and precolumn derivatization was developed for the simultaneous quantification of the major bile acids in Artificial Calculus bovis, including cholic acid, hyodeoxycholic acid, chenodeoxycholic acid, and deoxycholic acid. The extraction, derivatization, chromatographic separation, and detection parameters were fully optimized. The samples were extracted with methanol by ultrasonic extraction. Then, 2-bromine-4'-nitroacetophenone and 18-crown ether-6 were used for derivatization. The chromatographic separation was performed on an Agilent SB-C18 column (250 × 4.6 mm id, 5 μm) at a column temperature of 30°C and liquid flow rate of 1.0 mL/min using water and methanol as the mobile phase with a gradient elution. The detection wavelength was 263 nm. The method was extensively validated by evaluating the linearity (r(2) ≥ 0.9980), recovery (94.24-98.91%), limits of detection (0.25-0.31 ng) and limits of quantification (0.83-1.02 ng). Seventeen samples were analyzed using the developed and validated method. Then, the amounts of bile acids were analyzed by hierarchical agglomerative clustering analysis and principal component analysis. The results of the chemometric analysis showed that the contents of these compounds reflect the intrinsic quality of artificial Calculus bovis, and two compounds (hyodeoxycholic acid and chenodeoxycholic acid) were the most important markers for quality evaluating. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Development and validation of a sensitive LC-MS-MS method for the simultaneous determination of multicomponent contents in artificial Calculus Bovis.

    Science.gov (United States)

    Peng, Can; Tian, Jixin; Lv, Mengying; Huang, Yin; Tian, Yuan; Zhang, Zunjian

    2014-02-01

    Artificial Calculus Bovis is a major substitute in clinical treatment for Niuhuang, a widely used, efficacious but rare traditional Chinese medicine. However, its chemical structures and the physicochemical properties of its components are complicated, which causes difficulty in establishing a set of effective and comprehensive methods for its identification and quality control. In this study, a simple, sensitive and reliable liquid chromatography-tandem mass spectrometry method was successfully developed and validated for the simultaneous determination of bilirubin, taurine and major bile acids (including six unconjugated bile acids, two glycine-conjugated bile acids and three taurine-conjugated bile acids) in artificial Calculus Bovis using a Zorbax SB-C18 column with a gradient elution of methanol and 10 mmol/L ammonium acetate in aqueous solution (adjusted to pH 3.0 with formic acid). The mass spectra were obtained in the negative ion mode using dehydrocholic acid as the internal standard. The content of each analyte in artificial Calculus Bovis was determined by monitoring specific ion pairs in the selected reaction monitoring mode. All analytes demonstrated perfect linearity (r(2) > 0.994) in a wide dynamic range, and 10 batches of samples from different sources were further analyzed. This study provided a comprehensive method for the quality control of artificial Calculus Bovis.

  12. 牛黄解毒滴丸联合溃疡散治疗口腔溃疡106例疗效观察%Treatment of dental ulcer by Calculus Bovis Detoxication dropping pill combined with sucralfate

    Institute of Scientific and Technical Information of China (English)

    尹晓飞; 王书杰; 王文森; 蔡大伟

    2013-01-01

    Objective To study the curative effects of Calculus Bovis Detoxication dropping pill combined with sucralfate on dental ulcer. Methods 220 patients with dental ulcer were randomly divided into two groups, and they all took compound vitamin B tablets. The treatment group also buccally took Calculus Bovis Detoxication dropping pill combined with sucralfate, and 7 days were a course of treatment. The clinical curative effects of the two groups were observed. Results The total effective rate of the treatment group was 90. 57% . That of the control group was 68. 93% . The curative effects of the treatment group was significantly better than those of the control group( P <0. 05 ). Conclusion Treatment of dental ulcer by buccally taking Calculus Bovis Detoxication drilling pill combined with sucralfate is safe, effective, and cheap, which should be promoted.%目的 研究牛黄解毒滴丸联合溃疡散治疗口腔溃疡的临床疗效.方法 将220例患者随机分为2组,两组均给予复合维生素B片,治疗组另含服牛黄解毒滴丸联合溃疡散外敷治疗,疗程7 d.观察两组治疗后临床疗效.结果 治疗组的总有效率为90.57%,对照组的总有效率为68.93%,治疗组疗效明显优于对照组(P<0.05).结论 含服牛黄解毒滴丸联合溃疡散治疗口腔溃疡疗效安全高效、价格低廉,有临床推广价值.

  13. Calculus

    CERN Document Server

    Jones, Patrick

    2014-01-01

    Practice makes perfect-and helps deepen your understanding of calculus 1001 Calculus Practice Problems For Dummies takes you beyond the instruction and guidance offered in Calculus For Dummies, giving you 1001 opportunities to practice solving problems from the major topics in your calculus course. Plus, an online component provides you with a collection of calculus problems presented in multiple-choice format to further help you test your skills as you go. Gives you a chance to practice and reinforce the skills you learn in your calculus courseHelps you refine your understanding of calculusP

  14. Calculus

    CERN Document Server

    Larson, Ron

    2014-01-01

    The Larson CALCULUS program has a long history of innovation in the calculus market. It has been widely praised by a generation of students and professors for its solid and effective pedagogy that addresses the needs of a broad range of teaching and learning styles and environments. Each title is just one component in a comprehensive calculus course program that carefully integrates and coordinates print, media, and technology products for successful teaching and learning.

  15. Calculus

    CERN Document Server

    Grossman, Stanley I

    1981-01-01

    Calculus, Second Edition discusses the techniques and theorems of calculus. This edition introduces the sine and cosine functions, distributes ?-? material over several chapters, and includes a detailed account of analytic geometry and vector analysis.This book also discusses the equation of a straight line, trigonometric limit, derivative of a power function, mean value theorem, and fundamental theorems of calculus. The exponential and logarithmic functions, inverse trigonometric functions, linear and quadratic denominators, and centroid of a plane region are likewise elaborated. Other topics

  16. Calculus

    CERN Document Server

    Spivak, Michael

    2006-01-01

    Spivak's celebrated textbook is widely held as one of the finest introductions to mathematical analysis. His aim is to present calculus as the first real encounter with mathematics: it is the place to learn how logical reasoning combined with fundamental concepts can be developed into a rigorous mathematical theory rather than a bunch of tools and techniques learned by rote. Since analysis is a subject students traditionally find difficult to grasp, Spivak provides leisurely explanations, a profusion of examples, a wide range of exercises and plenty of illustrations in an easy-going approach that enlightens difficult concepts and rewards effort. Calculus will continue to be regarded as a modern classic, ideal for honours students and mathematics majors, who seek an alternative to doorstop textbooks on calculus, and the more formidable introductions to real analysis.

  17. Calculus

    CERN Document Server

    Grossman, Stanley I

    1984-01-01

    Calculus, Third Edition emphasizes the techniques and theorems of calculus, including many applied examples and exercises in both drill and applied-type problems.This book discusses shifting the graphs of functions, derivative as a rate of change, derivative of a power function, and theory of maxima and minima. The area between two curves, differential equations of exponential growth and decay, inverse hyperbolic functions, and integration of rational functions are also elaborated. This text likewise covers the fluid pressure, ellipse and translation of axes, graphing in polar coordinates, pro

  18. Calculus

    CERN Document Server

    Zandy, Bernard V

    2003-01-01

    We take great notes-and make learning a snap When it comes to pinpointing the stuff you really need to know, nobody does it better than CliffsNotes. This fast, effective tutorial helps you master core Calculus concepts-from functions, limits, and derivatives to differentials, integration, and definite integrals- and get the best possible grade. At CliffsNotes, we're dedicated to helping you do your best, no matter how challenging the subject. Our authors are veteran teachers and talented writers who know how to cut to the chase- and zero in on the essential information you need to succeed.

  19. Upregulation of PDZK1 by Calculus Bovis Sativus May Play an Important Role in Restoring Biliary Transport Function in Intrahepatic Cholestasis

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    Dong Xiang

    2017-01-01

    Full Text Available Intrahepatic cholestasis is a main cause of hepatic accumulation of bile acids leading to liver injury, fibrosis, and liver failure. Our previous studies proved that Calculus Bovis Sativus (CBS can restore biliary transport function through upregulating the multidrug resistance-associated protein 2 (MRP2 and breast cancer resistance protein (BCRP in 17α-ethynylestradiol- (EE- induced intrahepatic cholestasis rats. The regulation mechanism of CBS on these transporters, however, remains unclear. This study was designed to evaluate the possible relationship between the effect of CBS on transport activities and the regulation of CBS on the expression of PDZK1, a mainly scaffold protein which can regulate MRP2 and BCRP. Intrahepatic cholestasis model was induced in rats with injection of EE for five consecutive days and then the biliary excretion rates and cumulative biliary excretions were measured. The mRNA and protein expression levels of PDZK1 were detected by reverse transcription-quantitative real-time polymerase chain reaction, western blot, and immunohistochemical analysis. When treated with CBS, cumulative biliary excretions and mRNA and protein expressions of PDZK1 were significantly increased in intrahepatic cholestasis rats. This study demonstrated that CBS exerted a beneficial effect on EE-induced intrahepatic cholestasis rats by restoring biliary transport function, which may result from the upregulation of PDZK1 expression.

  20. Wick calculus on spaces of generalized functions of compound poisson white noise

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    Lytvynov, Eugene W.; Rebenko, Alexei L.; Shchepan'ur, Gennadi V.

    1997-04-01

    We derive white noise calculus for a compound Poisson process. Namely, we consider, on the Schwartz space of tempered distributions, S', a measure of compound Poisson white noise, μcp, and construct a whole scale of standard nuclear triples ( Scp) - x ⊃ L2cp) ≡ L2( S', dμcp) ⊃( Scpx, x≥ 0, which are obtained as images under some isomorphism of the corresponding triples centred at a Fock space. It turns out that the most interesting case is x = 1, when our triple coincides with the triple that is constructed by using a system of Appell polynomials in the framework of non-Gaussian biorthogonal analysis. Our special attention is paid to the Wick calculus of the Poisson field, or the quantum compound Poisson white noise process in other terms, which is the family of operators acting from ( Scp) 1 into ( Scp) 1 as multiplication by the compound Poisson white noise ω( t).

  1. Hepatoprotective effect of calculus bovis sativus on nonalcoholic fatty liver disease in mice by inhibiting oxidative stress and apoptosis of hepatocytes

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    He WX

    2017-12-01

    Full Text Available Wenxi He,1 Yanjiao Xu,1 Chengliang Zhang,1 Jingli Lu,2 Juan Li,1 Dong Xiang,1 Jinyu Yang,1 Mujun Chang,3 Dong Liu1 1Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; 2Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; 3Center for Translational Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Abstract: Calculus bovis (CB, niu-huang is a high-class therapeutic drug that is often used in traditional Chinese medicine. CB helps to eliminate heat and toxic components, and prevents the accumulation of phlegm and blood stasis in the liver. In Asian countries, CB Sativus (CBS, an ideal substitute for natural CB, is presently extensively used for long-term treatment of chronic liver diseases. The present study aimed to evaluate the effects and potential mechanism(s of action of CBS on mice with fructose-induced nonalcoholic fatty liver disease (NAFLD. The NAFLD model was established in C57BL/6 mice by exclusively feeding fluids containing 30% fructose for 8 consecutive weeks. After these 8 weeks, mice were given CBS (50 mg/kg/day or 100 mg/kg/day for 2 consecutive weeks. Treatment with CBS reversed the fructose-induced impaired glucose tolerance. Compared with the model group, in which mice received 8 weeks of high-fructose diet and 2 weeks of 0.5% sodium carboxymethyl cellulose, CBS treatment significantly decreased the levels of fasting serum glucose, fasting insulin, triglyceride, and total cholesterol, and increased levels of high-density lipoprotein-cholesterol. CBS treatment also significantly decreased the levels of triglyceride, total cholesterol, and free fatty acid in the liver. The activity of superoxide dismutase in the liver was increased after treatment with CBS, however, levels of malondialdehyde and reactive oxygen species decreased

  2. Tensor Calculus: Unlearning Vector Calculus

    Science.gov (United States)

    Lee, Wha-Suck; Engelbrecht, Johann; Moller, Rita

    2018-01-01

    Tensor calculus is critical in the study of the vector calculus of the surface of a body. Indeed, tensor calculus is a natural step-up for vector calculus. This paper presents some pitfalls of a traditional course in vector calculus in transitioning to tensor calculus. We show how a deeper emphasis on traditional topics such as the Jacobian can…

  3. Capsule calculus

    CERN Document Server

    Ritow, Ira

    2003-01-01

    This brief introductory text presents the basic principles of calculus from the engineering viewpoint. Excellent either as a refresher or as an introductory course, it focuses on developing familiarity with the basic principles rather than presenting detailed proofs.Topics include differential calculus, in terms of differentiation and elementary differential equations; integral calculus, in simple and multiple integration forms; time calculus; equations of motion and their solution; complex variables; complex algebra; complex functions; complex and operational calculus; and simple and inverse

  4. Continuation calculus

    NARCIS (Netherlands)

    Geron, B.; Geuvers, J.H.; de'Liguoro, U.; Saurin, A.

    2013-01-01

    Programs with control are usually modeled using lambda calculus extended with control operators. Instead of modifying lambda calculus, we consider a different model of computation. We introduce continuation calculus, or CC, a deterministic model of computation that is evaluated using only head

  5. Calculus light

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    Friedman, Menahem

    2011-01-01

    Another Calculus book? As long as students find calculus scary, the failure rate in mathematics is higher than in all other subjects, and as long as most people mistakenly believe that only geniuses can learn and understand mathematics, there will always be room for a new book of Calculus. We call it Calculus Light. This book is designed for a one semester course in ""light"" calculus -- mostly single variable, meant to be used by undergraduate students without a wide mathematical background and who do not major in mathematics but study subjects such as engineering, biology or management infor

  6. Tuplix Calculus

    OpenAIRE

    Bergstra, J. A.; Ponse, A.; van der Zwaag, M. B.

    2007-01-01

    We introduce a calculus for tuplices, which are expressions that generalize matrices and vectors. Tuplices have an underlying data type for quantities that are taken from a zero-totalized field. We start with the core tuplix calculus CTC for entries and tests, which are combined using conjunctive composition. We define a standard model and prove that CTC is relatively complete with respect to it. The core calculus is extended with operators for choice, information hiding, scalar multiplicatio...

  7. Operational calculus

    CERN Document Server

    Boehme, Thomas K

    1987-01-01

    Operational Calculus, Volume II is a methodical presentation of operational calculus. An outline of the general theory of linear differential equations with constant coefficients is presented. Integral operational calculus and advanced topics in operational calculus, including locally integrable functions and convergence in the space of operators, are also discussed. Formulas and tables are included.Comprised of four sections, this volume begins with a discussion on the general theory of linear differential equations with constant coefficients, focusing on such topics as homogeneous and non-ho

  8. Calculus refresher

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    Klaf, A A

    1956-01-01

    This book is unique in English as a refresher for engineers, technicians, and students who either wish to brush up their calculus or find parts of calculus unclear. It is not an ordinary textbook. It is, instead, an examination of the most important aspects of integral and differential calculus in terms of the 756 questions most likely to occur to the technical reader. It provides a very easily followed presentation and may also be used as either an introductory or supplementary textbook. The first part of this book covers simple differential calculus, with constants, variables, functions, inc

  9. Tuplix calculus

    NARCIS (Netherlands)

    Bergstra, J.A.; Ponse, A.; van der Zwaag, M.B.

    2008-01-01

    We introduce a calculus for tuplices, which are expressions that generalize matrices and vectors. Tuplices have an underlying data type for quantities that are taken from a zero-totalized field. We start with the core tuplix calculus CTC for entries and tests, which are combined using conjunctive

  10. Continuation calculus

    Directory of Open Access Journals (Sweden)

    Bram Geron

    2013-09-01

    Full Text Available Programs with control are usually modeled using lambda calculus extended with control operators. Instead of modifying lambda calculus, we consider a different model of computation. We introduce continuation calculus, or CC, a deterministic model of computation that is evaluated using only head reduction, and argue that it is suitable for modeling programs with control. It is demonstrated how to define programs, specify them, and prove them correct. This is shown in detail by presenting in CC a list multiplication program that prematurely returns when it encounters a zero. The correctness proof includes termination of the program. In continuation calculus we can model both call-by-name and call-by-value. In addition, call-by-name functions can be applied to call-by-value results, and conversely.

  11. Advanced calculus

    CERN Document Server

    Nickerson, HK; Steenrod, NE

    2011-01-01

    ""This book is a radical departure from all previous concepts of advanced calculus,"" declared the Bulletin of the American Mathematics Society, ""and the nature of this departure merits serious study of the book by everyone interested in undergraduate education in mathematics."" Classroom-tested in a Princeton University honors course, it offers students a unified introduction to advanced calculus. Starting with an abstract treatment of vector spaces and linear transforms, the authors introduce a single basic derivative in an invariant form. All other derivatives - gradient, divergent, curl,

  12. CLEP calculus

    CERN Document Server

    Hill, Gregory

    2013-01-01

    Earn College Credit with REA's Test Prep for CLEP* Calculus Everything you need to pass the exam and get the college credit you deserve.Our test prep for CLEP* Calculus and the free online tools that come with it, will allow you to create a personalized CLEP* study plan that can be customized to fit you: your schedule, your learning style, and your current level of knowledge.Here's how it works:Diagnostic exam at the REA Study Center focuses your studyOur online diagnostic exam pinpoints your strengths and shows you exactly where you need to focus your study. Armed with this information, you

  13. Matrix calculus

    CERN Document Server

    Bodewig, E

    1959-01-01

    Matrix Calculus, Second Revised and Enlarged Edition focuses on systematic calculation with the building blocks of a matrix and rows and columns, shunning the use of individual elements. The publication first offers information on vectors, matrices, further applications, measures of the magnitude of a matrix, and forms. The text then examines eigenvalues and exact solutions, including the characteristic equation, eigenrows, extremum properties of the eigenvalues, bounds for the eigenvalues, elementary divisors, and bounds for the determinant. The text ponders on approximate solutions, as well

  14. Calculus diaries

    CERN Document Server

    Ouellette,, Jennifer

    2011-01-01

    Jennifer Ouellette never took maths in the sixth form, mostly because she – like most of us – assumed she wouldn't need it much in real life. But then the English graduate, now an award-winning science-writer, had a change of heart and decided to revisit the equations and formulas that had haunted her youth. The Calculus Diaries is the fun and fascinating account of a year spent confronting her numbers-phobia head on. With wit and verve, Ouellette explains how she discovered that maths could apply to everything from petrol mileages to dieting, rollercoaster rides to winning in Las Vegas.

  15. Advanced calculus

    CERN Document Server

    Friedman, Avner

    2007-01-01

    This rigorous two-part treatment advances from functions of one variable to those of several variables. Intended for students who have already completed a one-year course in elementary calculus, it defers the introduction of functions of several variables for as long as possible, and adds clarity and simplicity by avoiding a mixture of heuristic and rigorous arguments.The first part explores functions of one variable, including numbers and sequences, continuous functions, differentiable functions, integration, and sequences and series of functions. The second part examines functions of several

  16. Advanced calculus

    CERN Document Server

    Fitzpatrick, Patrick M

    2009-01-01

    Advanced Calculus is intended as a text for courses that furnish the backbone of the student's undergraduate education in mathematical analysis. The goal is to rigorously present the fundamental concepts within the context of illuminating examples and stimulating exercises. This book is self-contained and starts with the creation of basic tools using the completeness axiom. The continuity, differentiability, integrability, and power series representation properties of functions of a single variable are established. The next few chapters describe the topological and metric properties of Euclide

  17. Renal calculus

    CERN Document Server

    Pyrah, Leslie N

    1979-01-01

    Stone in the urinary tract has fascinated the medical profession from the earliest times and has played an important part in the development of surgery. The earliest major planned operations were for the removal of vesical calculus; renal and ureteric calculi provided the first stimulus for the radiological investigation of the viscera, and the biochemical investigation of the causes of calculus formation has been the training ground for surgeons interested in metabolic disorders. It is therefore no surprise that stone has been the subject of a number of monographs by eminent urologists, but the rapid development of knowledge has made it possible for each one of these authors to produce something new. There is still a technical challenge to the surgeon in the removal of renal calculi, and on this topic we are always glad to have the advice of a master craftsman; but inevitably much of the interest centres on the elucidation of the causes of stone formation and its prevention. Professor Pyrah has had a long an...

  18. Calculator calculus

    CERN Document Server

    McCarty, George

    1982-01-01

    How THIS BOOK DIFFERS This book is about the calculus. What distinguishes it, however, from other books is that it uses the pocket calculator to illustrate the theory. A computation that requires hours of labor when done by hand with tables is quite inappropriate as an example or exercise in a beginning calculus course. But that same computation can become a delicate illustration of the theory when the student does it in seconds on his calculator. t Furthermore, the student's own personal involvement and easy accomplishment give hi~ reassurance and en­ couragement. The machine is like a microscope, and its magnification is a hundred millionfold. We shall be interested in limits, and no stage of numerical approximation proves anything about the limit. However, the derivative of fex) = 67.SgX, for instance, acquires real meaning when a student first appreciates its values as numbers, as limits of 10 100 1000 t A quick example is 1.1 , 1.01 , 1.001 , •••• Another example is t = 0.1, 0.01, in the functio...

  19. Propositional Calculus in Coq

    OpenAIRE

    van Doorn, Floris

    2015-01-01

    I formalize important theorems about classical propositional logic in the proof assistant Coq. The main theorems I prove are (1) the soundness and completeness of natural deduction calculus, (2) the equivalence between natural deduction calculus, Hilbert systems and sequent calculus and (3) cut elimination for sequent calculus.

  20. Calculus problems

    CERN Document Server

    Baronti, Marco; van der Putten, Robertus; Venturi, Irene

    2016-01-01

    This book, intended as a practical working guide for students in Engineering, Mathematics, Physics, or any other field where rigorous calculus is needed, includes 450 exercises. Each chapter starts with a summary of the main definitions and results, which is followed by a selection of solved exercises accompanied by brief, illustrative comments. A selection of problems with indicated solutions rounds out each chapter. A final chapter explores problems that are not designed with a single issue in mind but instead call for the combination of a variety of techniques, rounding out the book’s coverage. Though the book’s primary focus is on functions of one real variable, basic ordinary differential equations (separation of variables, linear first order and constant coefficients ODEs) are also discussed. The material is taken from actual written tests that have been delivered at the Engineering School of the University of Genoa. Literally thousands of students have worked on these problems, ensuring their real-...

  1. Calculus of one variable

    CERN Document Server

    Grossman, Stanley I

    1986-01-01

    Calculus of One Variable, Second Edition presents the essential topics in the study of the techniques and theorems of calculus.The book provides a comprehensive introduction to calculus. It contains examples, exercises, the history and development of calculus, and various applications. Some of the topics discussed in the text include the concept of limits, one-variable theory, the derivatives of all six trigonometric functions, exponential and logarithmic functions, and infinite series.This textbook is intended for use by college students.

  2. Vector Differential Calculus

    OpenAIRE

    HITZER, Eckhard MS

    2002-01-01

    This paper treats the fundamentals of the vector differential calculus part of universal geometric calculus. Geometric calculus simplifies and unifies the structure and notation of mathematics for all of science and engineering, and for technological applications. In order to make the treatment self-contained, I first compile all important geometric algebra relationships,which are necesssary for vector differential calculus. Then differentiation by vectors is introduced and a host of major ve...

  3. On the refinement calculus

    CERN Document Server

    Vickers, Trevor

    1992-01-01

    On the Refinement Calculus gives one view of the development of the refinement calculus and its attempt to bring together - among other things - Z specifications and Dijkstra's programming language. It is an excellent source of reference material for all those seeking the background and mathematical underpinnings of the refinement calculus.

  4. Fundamentals of calculus

    CERN Document Server

    Morris, Carla C

    2015-01-01

    Fundamentals of Calculus encourages students to use power, quotient, and product rules for solutions as well as stresses the importance of modeling skills.  In addition to core integral and differential calculus coverage, the book features finite calculus, which lends itself to modeling and spreadsheets.  Specifically, finite calculus is applied to marginal economic analysis, finance, growth, and decay.  Includes: Linear Equations and FunctionsThe DerivativeUsing the Derivative Exponential and Logarithmic Functions Techniques of DifferentiationIntegral CalculusIntegration TechniquesFunctions

  5. Calculus II For Dummies

    CERN Document Server

    Zegarelli, Mark

    2012-01-01

    An easy-to-understand primer on advanced calculus topics Calculus II is a prerequisite for many popular college majors, including pre-med, engineering, and physics. Calculus II For Dummies offers expert instruction, advice, and tips to help second semester calculus students get a handle on the subject and ace their exams. It covers intermediate calculus topics in plain English, featuring in-depth coverage of integration, including substitution, integration techniques and when to use them, approximate integration, and improper integrals. This hands-on guide also covers sequences and series, wit

  6. Noncausal stochastic calculus

    CERN Document Server

    Ogawa, Shigeyoshi

    2017-01-01

    This book presents an elementary introduction to the theory of noncausal stochastic calculus that arises as a natural alternative to the standard theory of stochastic calculus founded in 1944 by Professor Kiyoshi Itô. As is generally known, Itô Calculus is essentially based on the "hypothesis of causality", asking random functions to be adapted to a natural filtration generated by Brownian motion or more generally by square integrable martingale. The intention in this book is to establish a stochastic calculus that is free from this "hypothesis of causality". To be more precise, a noncausal theory of stochastic calculus is developed in this book, based on the noncausal integral introduced by the author in 1979. After studying basic properties of the noncausal stochastic integral, various concrete problems of noncausal nature are considered, mostly concerning stochastic functional equations such as SDE, SIE, SPDE, and others, to show not only the necessity of such theory of noncausal stochastic calculus but ...

  7. The quantum probability calculus

    International Nuclear Information System (INIS)

    Jauch, J.M.

    1976-01-01

    The Wigner anomaly (1932) for the joint distribution of noncompatible observables is an indication that the classical probability calculus is not applicable for quantum probabilities. It should, therefore, be replaced by another, more general calculus, which is specifically adapted to quantal systems. In this article this calculus is exhibited and its mathematical axioms and the definitions of the basic concepts such as probability field, random variable, and expectation values are given. (B.R.H)

  8. Mycobacterium bovis Infection of Red Fox, France.

    Science.gov (United States)

    Michelet, Lorraine; De Cruz, Krystel; Hénault, Sylvie; Tambosco, Jennifer; Richomme, Céline; Réveillaud, Édouard; Gares, Hélène; Moyen, Jean-Louis; Boschiroli, María Laura

    2018-06-01

    Mycobacterium bovis infection in wild red foxes was found in southern France, where livestock and other wildlife species are infected. Foxes frequently interact with cattle but have been underestimated as a reservoir of M. bovis. Our results suggest a possible role of the red fox in the epidemiology of bovine tuberculosis.

  9. Mycobacterium bovis (Bovine Tuberculosis) in Humans

    Science.gov (United States)

    ... bovis is usually resistant to one of the antibiotics, pyrazinamide, typically used to treat TB disease. However, resistance to just ... disease is treated with a combination of several antibiotics. Latent infection without ... livestock producers, has nearly eliminated M. bovis infection from ...

  10. Disappearing renal calculus.

    Science.gov (United States)

    Cui, Helen; Thomas, Johanna; Kumar, Sunil

    2013-04-10

    We present a case of a renal calculus treated solely with antibiotics which has not been previously reported in the literature. A man with a 17 mm lower pole renal calculus and concurrent Escherichia coli urine infection was being worked up to undergo percutaneous nephrolithotomy. However, after a course of preoperative antibiotics the stone was no longer seen on retrograde pyelography or CT imaging.

  11. Initialized Fractional Calculus

    Science.gov (United States)

    Lorenzo, Carl F.; Hartley, Tom T.

    2000-01-01

    This paper demonstrates the need for a nonconstant initialization for the fractional calculus and establishes a basic definition set for the initialized fractional differintegral. This definition set allows the formalization of an initialized fractional calculus. Two basis calculi are considered; the Riemann-Liouville and the Grunwald fractional calculi. Two forms of initialization, terminal and side are developed.

  12. Paragrassmann differential calculus

    International Nuclear Information System (INIS)

    Filippov, A.T.; Isaev, A.P.; Kurdikov, A.V.

    1993-01-01

    This paper significantly extends and generalizes the paragrassmann calculus previous paper. Explicit general constructions for paragrassmann calculus with one and many vaiables are discussed. A general construction of many-variable differentiation algebras is given. Some particular examples are related to multi-parametric quantum deformation of the harmonic oscillators

  13. Hands-On Calculus

    Science.gov (United States)

    Sutherland, Melissa

    2006-01-01

    In this paper we discuss manipulatives and hands-on investigations for Calculus involving volume, arc length, and surface area to motivate and develop formulae which can then be verified using techniques of integration. Pre-service teachers in calculus courses using these activities experience a classroom in which active learning is encouraged and…

  14. On exterior variational calculus

    International Nuclear Information System (INIS)

    Aldrovandi, R.; Kraenkel, R.A.

    1987-01-01

    Exterior variational calculus is introduced through examples in field theory. It provides a very simple technique to decide on the existence of Lagrangians for given equations of motions and, in the case, to find them. Only local aspects are discussed but the analogy to exterior calculus on finite dimensional manifolds is complete, strongly suggesting its suitability to the study of topological aspects. (Author) [pt

  15. Teaching the Calculus

    Science.gov (United States)

    Sauerheber, Richard D.

    2012-01-01

    Methods of teaching the Calculus are presented in honour of Sir Isaac Newton, by discussing an extension of his original proofs and discoveries. The methods, requested by Newton to be used that reflect the historical sequence of the discovered Fundamental Theorems, allow first-time students to grasp quickly the basics of the Calculus from its…

  16. Essential calculus with applications

    CERN Document Server

    Silverman, Richard A

    1989-01-01

    Rigorous but accessible text introduces undergraduate-level students to necessary background math, then clear coverage of differential calculus, differentiation as a tool, integral calculus, integration as a tool, and functions of several variables. Numerous problems and a supplementary section of ""Hints and Answers."" 1977 edition.

  17. Cryopreservation of Mycobacterium bovis isolates

    Directory of Open Access Journals (Sweden)

    Cássia Yumi Ikuta

    2016-11-01

    Full Text Available Research, development of new biotechnological methods, diagnostic tests, confirmation of results, and reinvestigations are possible because of the availability of well-preserved living organisms maintained without any changes. Cryopreservation is a simpler, more reliable and long-term stable method for culture maintenance. Storage temperature and composition of the suspending vehicle are factors that affect the viability of mycobacterial strains. Three vehicles and three storage temperatures were evaluated to define a suitable cryoprotective medium for the preservation of Mycobacterium bovis strains. Colonies of sixteen M. bovis isolates were used to prepare the suspensions, which were then added to three vehicles: sterile 0.85% saline solution (SS, Middlebrook 7H9 broth (7H9, and Middlebrook 7H9 broth with sodium pyruvate (7H9p replacing glycerol. Aliquots of these suspensions were frozen by three different methods, directly in the -20°C freezer, directly in the -80°C freezer, and at -196°C by immersion in liquid nitrogen (LN. The frozen aliquots were thawed at room temperature after 45, 90 and 120 days. Mycobacterial viability was assessed by counting the living cells on plates of Stonebrink medium before and after the freezing procedure. Storage at -20°C exhibited a lower recovery of M. bovis compared to storage at -80°C (Dunn’s test, p=0.0018 and LN (Dunn’s test, p=0.0352. There was no statistically significant difference between storage at -80°C and in LN (Dunn’s test, p=0.1403, yet -80°C showed better results than LN. All three suspending vehicles showed no statistically significant difference in terms of viability (Friedman’s test, p=0.7765. Given the low loss proportion of 5% during storage at -20°C and the high cost equipment required for storage at -80°C and LN, we recommend storage at -20°C or -80°C, when this is available, for preservation of M. bovis field strains.

  18. Multivariable calculus with applications

    CERN Document Server

    Lax, Peter D

    2017-01-01

    This text in multivariable calculus fosters comprehension through meaningful explanations. Written with students in mathematics, the physical sciences, and engineering in mind, it extends concepts from single variable calculus such as derivative, integral, and important theorems to partial derivatives, multiple integrals, Stokes’ and divergence theorems. Students with a background in single variable calculus are guided through a variety of problem solving techniques and practice problems. Examples from the physical sciences are utilized to highlight the essential relationship between calculus and modern science. The symbiotic relationship between science and mathematics is shown by deriving and discussing several conservation laws, and vector calculus is utilized to describe a number of physical theories via partial differential equations. Students will learn that mathematics is the language that enables scientific ideas to be precisely formulated and that science is a source for the development of mathemat...

  19. Discrete fractional calculus

    CERN Document Server

    Goodrich, Christopher

    2015-01-01

    This text provides the first comprehensive treatment of the discrete fractional calculus. Experienced researchers will find the text useful as a reference for discrete fractional calculus and topics of current interest. Students who are interested in learning about discrete fractional calculus will find this text to provide a useful starting point. Several exercises are offered at the end of each chapter and select answers have been provided at the end of the book. The presentation of the content is designed to give ample flexibility for potential use in a myriad of courses and for independent study. The novel approach taken by the authors includes a simultaneous treatment of the fractional- and integer-order difference calculus (on a variety of time scales, including both the usual forward and backwards difference operators). The reader will acquire a solid foundation in the classical topics of the discrete calculus while being introduced to exciting recent developments, bringing them to the frontiers of the...

  20. Calculus with applications

    CERN Document Server

    Lax, Peter D

    2014-01-01

    This new edition of Lax, Burstein, and Lax's Calculus with Applications and Computing offers meaningful explanations of the important theorems of single variable calculus. Written with students in mathematics, the physical sciences, and engineering in mind, and revised with their help, it shows that the themes of calculation, approximation, and modeling are central to mathematics and the main ideas of single variable calculus. This edition brings the innovation of the first edition to a new generation of students. New sections in this book use simple, elementary examples to show that when applying calculus concepts to approximations of  functions, uniform convergence is more natural and easier to use than point-wise convergence. As in the original, this edition includes material that is essential for students in science and engineering, including an elementary introduction to complex numbers and complex-valued functions, applications of calculus to modeling vibrations and population dynamics, and an introduc...

  1. Impact of Calculus Reform in a Liberal Arts Calculus Course.

    Science.gov (United States)

    Brosnan, Patricia A.; Ralley, Thomas G.

    This report describes the changes in a freshman-level calculus course that occurred as a consequence of adopting the Harvard Consortium Calculus text. The perspective is that of the lecturer. The course is intended as an introduction to calculus for liberal arts students, that is, students who will not be expected to use calculus as a mathematical…

  2. Calculus of variations

    CERN Document Server

    Elsgolc, L E; Stark, M

    1961-01-01

    Calculus of Variations aims to provide an understanding of the basic notions and standard methods of the calculus of variations, including the direct methods of solution of the variational problems. The wide variety of applications of variational methods to different fields of mechanics and technology has made it essential for engineers to learn the fundamentals of the calculus of variations. The book begins with a discussion of the method of variation in problems with fixed boundaries. Subsequent chapters cover variational problems with movable boundaries and some other problems; sufficiency

  3. Stochastic calculus in physics

    International Nuclear Information System (INIS)

    Fox, R.F.

    1987-01-01

    The relationship of Ito-Stratonovich stochastic calculus to studies of weakly colored noise is explained. A functional calculus approach is used to obtain an effective Fokker-Planck equation for the weakly colored noise regime. In a smooth limit, this representation produces the Stratonovich version of the Ito-Stratonovich calculus for white noise. It also provides an approach to steady state behavior for strongly colored noise. Numerical simulation algorithms are explored, and a novel suggestion is made for efficient and accurate simulation of white noise equations

  4. The stochastic quality calculus

    DEFF Research Database (Denmark)

    Zeng, Kebin; Nielson, Flemming; Nielson, Hanne Riis

    2014-01-01

    We introduce the Stochastic Quality Calculus in order to model and reason about distributed processes that rely on each other in order to achieve their overall behaviour. The calculus supports broadcast communication in a truly concurrent setting. Generally distributed delays are associated...... with the outputs and at the same time the inputs impose constraints on the waiting times. Consequently, the expected inputs may not be available when needed and therefore the calculus allows to express the absence of data.The communication delays are expressed by general distributions and the resulting semantics...

  5. Calculus for dummies

    CERN Document Server

    Ryan, Mark

    2014-01-01

    Slay the calculus monster with this user-friendly guide Calculus For Dummies, 2nd Edition makes calculus manageable-even if you're one of the many students who sweat at the thought of it. By breaking down differentiation and integration into digestible concepts, this guide helps you build a stronger foundation with a solid understanding of the big ideas at work. This user-friendly math book leads you step-by-step through each concept, operation, and solution, explaining the ""how"" and ""why"" in plain English instead of math-speak. Through relevant instruction and practical examples, you'll s

  6. A Logical Process Calculus

    Science.gov (United States)

    Cleaveland, Rance; Luettgen, Gerald; Bushnell, Dennis M. (Technical Monitor)

    2002-01-01

    This paper presents the Logical Process Calculus (LPC), a formalism that supports heterogeneous system specifications containing both operational and declarative subspecifications. Syntactically, LPC extends Milner's Calculus of Communicating Systems with operators from the alternation-free linear-time mu-calculus (LT(mu)). Semantically, LPC is equipped with a behavioral preorder that generalizes Hennessy's and DeNicola's must-testing preorder as well as LT(mu's) satisfaction relation, while being compositional for all LPC operators. From a technical point of view, the new calculus is distinguished by the inclusion of: (1) both minimal and maximal fixed-point operators and (2) an unimple-mentability predicate on process terms, which tags inconsistent specifications. The utility of LPC is demonstrated by means of an example highlighting the benefits of heterogeneous system specification.

  7. Generalized Gaussian Error Calculus

    CERN Document Server

    Grabe, Michael

    2010-01-01

    For the first time in 200 years Generalized Gaussian Error Calculus addresses a rigorous, complete and self-consistent revision of the Gaussian error calculus. Since experimentalists realized that measurements in general are burdened by unknown systematic errors, the classical, widespread used evaluation procedures scrutinizing the consequences of random errors alone turned out to be obsolete. As a matter of course, the error calculus to-be, treating random and unknown systematic errors side by side, should ensure the consistency and traceability of physical units, physical constants and physical quantities at large. The generalized Gaussian error calculus considers unknown systematic errors to spawn biased estimators. Beyond, random errors are asked to conform to the idea of what the author calls well-defined measuring conditions. The approach features the properties of a building kit: any overall uncertainty turns out to be the sum of a contribution due to random errors, to be taken from a confidence inter...

  8. Isolation and molecular characterisation of Mycobacterium bovis ...

    African Journals Online (AJOL)

    : Three hundred and six milk samples collected from 102 infected cows in different Tunisian regions were analysed. M. bovis isolates were further characterized by spoligotyping and variable number tandem repeat typing. Results: A total of ...

  9. General quantum variational calculus

    Directory of Open Access Journals (Sweden)

    Artur M. C. Brito da Cruz

    2018-02-01

    Full Text Available We develop a new variational calculus based in the general quantum difference operator recently introduced by Hamza et al. In particular, we obtain optimality conditions for generalized variational problems where the Lagrangian may depend on the endpoints conditions and a real parameter, for the basic and isoperimetric problems, with and without fixed boundary conditions. Our results provide a generalization to previous results obtained for the $q$- and Hahn-calculus.

  10. The stack calculus

    Directory of Open Access Journals (Sweden)

    Alberto Carraro

    2013-03-01

    Full Text Available We introduce a functional calculus with simple syntax and operational semantics in which the calculi introduced so far in the Curry-Howard correspondence for Classical Logic can be faithfully encoded. Our calculus enjoys confluence without any restriction. Its type system enforces strong normalization of expressions and it is a sound and complete system for full implicational Classical Logic. We give a very simple denotational semantics which allows easy calculations of the interpretation of expressions.

  11. Discounted Duration Calculus

    DEFF Research Database (Denmark)

    Ody, Heinrich; Fränzle, Martin; Hansen, Michael Reichhardt

    2016-01-01

    To formally reason about the temporal quality of systems discounting was introduced to CTL and LTL. However, these logic are discrete and they cannot express duration properties. In this work we introduce discounting for a variant of Duration Calculus. We prove decidability of model checking...... for a useful fragment of discounted Duration Calculus formulas on timed automata under mild assumptions. Further, we provide an extensive example to show the usefulness of the fragment....

  12. Calculus of bivariant function

    OpenAIRE

    PTÁČNÍK, Jan

    2011-01-01

    This thesis deals with the introduction of function of two variables and differential calculus of this function. This work should serve as a textbook for students of elementary school's teacher. Each chapter contains a summary of basic concepts and explanations of relationships, then solved model exercises of the topic and finally the exercises, which should solve the student himself. Thesis have transmit to students basic knowledges of differential calculus of functions of two variables, inc...

  13. Quantum Variational Calculus

    OpenAIRE

    Malinowska , Agnieszka B.; Torres , Delfim

    2014-01-01

    International audience; Introduces readers to the treatment of the calculus of variations with q-differences and Hahn difference operators Provides the reader with the first extended treatment of quantum variational calculus Shows how the techniques described can be applied to economic models as well as other mathematical systems This Brief puts together two subjects, quantum and variational calculi by considering variational problems involving Hahn quantum operators. The main advantage of it...

  14. Computing for calculus

    CERN Document Server

    Christensen, Mark J

    1981-01-01

    Computing for Calculus focuses on BASIC as the computer language used for solving calculus problems.This book discusses the input statement for numeric variables, advanced intrinsic functions, numerical estimation of limits, and linear approximations and tangents. The elementary estimation of areas, numerical and string arrays, line drawing algorithms, and bisection and secant method are also elaborated. This text likewise covers the implicit functions and differentiation, upper and lower rectangular estimates, Simpson's rule and parabolic approximation, and interpolating polynomials. Other to

  15. The absolute differential calculus calculus of tensors

    CERN Document Server

    Levi-Cività, Tullio

    1926-01-01

    Written by a towering figure of twentieth-century mathematics, this classic examines the mathematical background necessary for a grasp of relativity theory. Tullio Levi-Civita provides a thorough treatment of the introductory theories that form the basis for discussions of fundamental quadratic forms and absolute differential calculus, and he further explores physical applications.Part one opens with considerations of functional determinants and matrices, advancing to systems of total differential equations, linear partial differential equations, algebraic foundations, and a geometrical intro

  16. A pilot study exploring the use of breath analysis to differentiate healthy cattle from cattle experimentally infected with Mycobacterium bovis.

    Directory of Open Access Journals (Sweden)

    Christine K Ellis

    Full Text Available Bovine tuberculosis, caused by Mycobacterium bovis, is a zoonotic disease of international public health importance. Ante-mortem surveillance is essential for control; however, current surveillance tests are hampered by limitations affecting ease of use or quality of results. There is an emerging interest in human and veterinary medicine in diagnosing disease via identification of volatile organic compounds produced by pathogens and host-pathogen interactions. The objective of this pilot study was to explore application of existing human breath collection and analysis methodologies to cattle as a means to identify M. bovis infection through detection of unique volatile organic compounds or changes in the volatile organic compound profiles present in breath. Breath samples from 23 male Holstein calves (7 non-infected and 16 M. bovis-infected were collected onto commercially available sorbent cartridges using a mask system at 90 days post-inoculation with M. bovis. Samples were analyzed using gas chromatography-mass spectrometry, and chromatographic data were analyzed using standard analytical chemical and metabolomic analyses, principle components analysis, and a linear discriminant algorithm. The findings provide proof of concept that breath-derived volatile organic compound analysis can be used to differentiate between healthy and M. bovis-infected cattle.

  17. A Pilot Study Exploring the Use of Breath Analysis to Differentiate Healthy Cattle from Cattle Experimentally Infected with Mycobacterium bovis

    Science.gov (United States)

    Ellis, Christine K.; Stahl, Randal S.; Nol, Pauline; Waters, W. Ray; Palmer, Mitchell V.; Rhyan, Jack C.; VerCauteren, Kurt C.; McCollum, Matthew; Salman, M. D.

    2014-01-01

    Bovine tuberculosis, caused by Mycobacterium bovis, is a zoonotic disease of international public health importance. Ante-mortem surveillance is essential for control; however, current surveillance tests are hampered by limitations affecting ease of use or quality of results. There is an emerging interest in human and veterinary medicine in diagnosing disease via identification of volatile organic compounds produced by pathogens and host-pathogen interactions. The objective of this pilot study was to explore application of existing human breath collection and analysis methodologies to cattle as a means to identify M. bovis infection through detection of unique volatile organic compounds or changes in the volatile organic compound profiles present in breath. Breath samples from 23 male Holstein calves (7 non-infected and 16 M. bovis-infected) were collected onto commercially available sorbent cartridges using a mask system at 90 days post-inoculation with M. bovis. Samples were analyzed using gas chromatography-mass spectrometry, and chromatographic data were analyzed using standard analytical chemical and metabolomic analyses, principle components analysis, and a linear discriminant algorithm. The findings provide proof of concept that breath-derived volatile organic compound analysis can be used to differentiate between healthy and M. bovis-infected cattle. PMID:24586655

  18. Abortion associated with Mycoplasma bovis (M. bovis) in a bison (Bison bison) herd

    Science.gov (United States)

    Mycoplasma bovis (M. bovis) has recently emerged as a significant health threat in bison and is an increasing concern and source of economic loss for producers. Clinical manifestations of infection documented in bison include pneumonia, respiratory distress and polyarthritis. The current study des...

  19. Putting Differentials Back into Calculus

    Science.gov (United States)

    Dray, Tevian; Manogue, Corrine A.

    2010-01-01

    We argue that the use of differentials in introductory calculus courses is useful and provides a unifying theme, leading to a coherent view of the calculus. Along the way, we meet several interpretations of differentials, some better than others.

  20. Effect of milk fermentation by kefir grains and selected single strains of lactic acid bacteria on the survival of Mycobacterium bovis BCG.

    Science.gov (United States)

    Macuamule, C L S; Wiid, I J; van Helden, P D; Tanner, M; Witthuhn, R C

    2016-01-18

    Mycobacterium bovis that causes Bovine tuberculosis (BTB) can be transmitted to humans thought consumption of raw and raw fermented milk products from diseased animals. Lactic acid bacteria (LAB) used in popular traditional milk products in Africa produce anti-microbial compounds that inhibit some pathogenic and spoilage bacteria. M. bovis BCG is an attenuated non-pathogenic vaccine strain of M. bovis and the aim of the study was to determine the effect of the fermentation process on the survival of M. bovis BCG in milk. M. bovis BCG at concentrations of 6 log CFU/ml was added to products of kefir fermentation. The survival of M. bovis BCG was monitored at 12-h intervals for 72 h by enumerating viable cells on Middlebrook 7H10 agar plates enriched with 2% BD BACTEC PANTA™. M. bovis BCG was increasingly reduced in sterile kefir that was fermented for a period of 24h and longer. In the milk fermented with kefir grains, Lactobacillus paracasei subsp. paracasei or Lactobacillus casei, the viability of M. bovis BCG was reduced by 0.4 logs after 24h and by 2 logs after 48 h of fermentation. No viable M. bovis BCG was detected after 60 h of fermentation. Results from this study show that long term fermentation under certain conditions may have the potential to inactivate M. bovis BCG present in the milk. However, to ensure safety of fermented milk in Africa, fermentation should be combined with other hurdle technologies such as boiling and milk pasteurisation. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Quantum variational calculus

    CERN Document Server

    Malinowska, Agnieszka B

    2014-01-01

    This Brief puts together two subjects, quantum and variational calculi by considering variational problems involving Hahn quantum operators. The main advantage of its results is that they are able to deal with nondifferentiable (even discontinuous) functions, which are important in applications. Possible applications in economics are discussed. Economists model time as continuous or discrete. Although individual economic decisions are generally made at discrete time intervals, they may well be less than perfectly synchronized in ways discrete models postulate. On the other hand, the usual assumption that economic activity takes place continuously, is nothing else than a convenient abstraction that in many applications is far from reality. The Hahn quantum calculus helps to bridge the gap between the two families of models: continuous and discrete. Quantum Variational Calculus is self-contained and unified in presentation. It provides an opportunity for an introduction to the quantum calculus of variations fo...

  2. Noncommutative operational calculus

    Directory of Open Access Journals (Sweden)

    Henry E. Heatherly

    1999-12-01

    Full Text Available Oliver Heaviside's operational calculus was placed on a rigorous mathematical basis by Jan Mikusinski, who constructed an algebraic setting for the operational methods. In this paper, we generalize Mikusi'{n}ski's methods to solve linear ordinary differential equations in which the unknown is a matrix- or linear operator-valued function. Because these functions can be zero-divisors and do not necessarily commute, Mikusi'{n}ski's one-dimensional calculus cannot be used. The noncommuative operational calculus developed here,however, is used to solve a wide class of such equations. In addition, we provide new proofs of existence and uniqueness theorems for certain matrix- and operator valued Volterra integral and integro-differential equations. Several examples are given which demonstrate these new methods.

  3. Topology, calculus and approximation

    CERN Document Server

    Komornik, Vilmos

    2017-01-01

    Presenting basic results of topology, calculus of several variables, and approximation theory which are rarely treated in a single volume, this textbook includes several beautiful, but almost forgotten, classical theorems of Descartes, Erdős, Fejér, Stieltjes, and Turán. The exposition style of Topology, Calculus and Approximation follows the Hungarian mathematical tradition of Paul Erdős and others. In the first part, the classical results of Alexandroff, Cantor, Hausdorff, Helly, Peano, Radon, Tietze and Urysohn illustrate the theories of metric, topological and normed spaces. Following this, the general framework of normed spaces and Carathéodory's definition of the derivative are shown to simplify the statement and proof of various theorems in calculus and ordinary differential equations. The third and final part is devoted to interpolation, orthogonal polynomials, numerical integration, asymptotic expansions and the numerical solution of algebraic and differential equations. Students of both pure an...

  4. Typebestemmelse af de danske M. bovis stammer

    DEFF Research Database (Denmark)

    Kokotovic, Branko

    Mycoplasma bovis er en af de mest betydningsfulde mykoplasma i kvægbruget på verdensplan. Bakterien findes oftest i forbindelse med mastitis, lunge- og ledbetændelse, men andre kliniske manifestationer kan også forekomme. Der findes ikke præcise, nyere beregninger over konsekvenser af M. bovis...... relateret sygdomme, men det anses, at infektionen hvert år globalt set pålægger en økonomisk byrde til kvægbruget i en multimillion skala. M. bovis blev for første gang påvist i Danmark i 1981 og gennem 1980’erne har bakterien forårsaget store udbrud af mastitis. I de følgende årtier blev bakterien isoleret...... sporadisk fra mange forskellige kvægbesætninger, men på trods af en tilsyneladende stigende forekomst i 1990’erne, blev der ikke registret omfattende sundhedsmæssige problemer som følge af M. bovis smitte. Siden 2011 er M. bovis dog kommet i fokus igen på grund af alvorlige udbrud af især ledbetændelse, men...

  5. Maxima and Minima Without Calculus.

    Science.gov (United States)

    Birnbaum, Ian

    1982-01-01

    Approaches to extrema that do not require calculus are presented to help free maxima/minima problems from the confines of calculus. Many students falsely suppose that these types of problems can only be dealt with through calculus, since few, if any, noncalculus examples are usually presented. (MP)

  6. 9 CFR 113.409 - Tuberculin-PPD Bovis, Intradermic.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Tuberculin-PPD Bovis, Intradermic. 113... REQUIREMENTS Diagnostics and Reagents § 113.409 Tuberculin—PPD Bovis, Intradermic. Tuberculin—PPD Bovis... completed product from each serial shall be subjected to a comparison specificity test using a Reference PPD...

  7. The calculus primer

    CERN Document Server

    Schaaf, William L

    2011-01-01

    Comprehensive but concise, this introduction to differential and integral calculus covers all the topics usually included in a first course. The straightforward development places less emphasis on mathematical rigor, and the informal manner of presentation sets students at ease. Many carefully worked-out examples illuminate the text, in addition to numerous diagrams, problems, and answers.Bearing the needs of beginners constantly in mind, the treatment covers all the basic concepts of calculus: functions, derivatives, differentiation of algebraic and transcendental functions, partial different

  8. A calculus for quality

    DEFF Research Database (Denmark)

    Nielson, Hanne Riis; Nielson, Flemming; Vigo, Roberto

    2013-01-01

    for default behaviour in case the ideal behaviour fails due to unreliable communication and thereby to increase the quality of service offered by the systems. The development is facilitated by a SAT-based robustness analysis to determine whether or not the code is vulnerable to unreliable communication......A main challenge of programming component-based software is to ensure that the components continue to behave in a reasonable manner even when communication becomes unreliable. We propose a process calculus, the Quality Calculus, for programming software components where it becomes natural to plan...

  9. Functional Fractional Calculus

    CERN Document Server

    Das, Shantanu

    2011-01-01

    When a new extraordinary and outstanding theory is stated, it has to face criticism and skeptism, because it is beyond the usual concept. The fractional calculus though not new, was not discussed or developed for a long time, particularly for lack of its application to real life problems. It is extraordinary because it does not deal with 'ordinary' differential calculus. It is outstanding because it can now be applied to situations where existing theories fail to give satisfactory results. In this book not only mathematical abstractions are discussed in a lucid manner, with physical mathematic

  10. Two-dimensional calculus

    CERN Document Server

    Osserman, Robert

    2011-01-01

    The basic component of several-variable calculus, two-dimensional calculus is vital to mastery of the broader field. This extensive treatment of the subject offers the advantage of a thorough integration of linear algebra and materials, which aids readers in the development of geometric intuition. An introductory chapter presents background information on vectors in the plane, plane curves, and functions of two variables. Subsequent chapters address differentiation, transformations, and integration. Each chapter concludes with problem sets, and answers to selected exercises appear at the end o

  11. A Giant Urethral Calculus.

    Science.gov (United States)

    Sigdel, G; Agarwal, A; Keshaw, B W

    2014-01-01

    Urethral calculi are rare forms of urolithiasis. Majority of the calculi are migratory from urinary bladder or upper urinary tract. Primary urethral calculi usually occur in presence of urethral stricture or diverticulum. In this article we report a case of a giant posterior urethral calculus measuring 7x3x2 cm in a 47 years old male. Patient presented with acute retention of urine which was preceded by burning micturition and dribbling of urine for one week. The calculus was pushed in to the bladder through the cystoscope and was removed by suprapubic cystolithotomy.

  12. Schaum's outline of calculus

    CERN Document Server

    Ayres, Frank

    1999-01-01

    Students can gain a thorough understanding of differential and integral calculus with this powerful study tool. They'll also find the related analytic geometry much easier. The clear review of algebra and geometry in this edition will make calculus easier for students who wish to strengthen their knowledge in these areas. Updated to meet the emphasis in current courses, this new edition of a popular guide­­--more than 104,000 copies were bought of the prior edition--­­includes problems and examples using graphing calculators.

  13. Discrete Calculus by Analogy

    CERN Document Server

    Izadi, F A; Bagirov, G

    2009-01-01

    With its origins stretching back several centuries, discrete calculus is now an increasingly central methodology for many problems related to discrete systems and algorithms. The topics covered here usually arise in many branches of science and technology, especially in discrete mathematics, numerical analysis, statistics and probability theory as well as in electrical engineering, but our viewpoint here is that these topics belong to a much more general realm of mathematics; namely calculus and differential equations because of the remarkable analogy of the subject to this branch of mathemati

  14. The dagger lambda calculus

    Directory of Open Access Journals (Sweden)

    Philip Atzemoglou

    2014-12-01

    Full Text Available We present a novel lambda calculus that casts the categorical approach to the study of quantum protocols into the rich and well established tradition of type theory. Our construction extends the linear typed lambda calculus with a linear negation of "trivialised" De Morgan duality. Reduction is realised through explicit substitution, based on a symmetric notion of binding of global scope, with rules acting on the entire typing judgement instead of on a specific subterm. Proofs of subject reduction, confluence, strong normalisation and consistency are provided, and the language is shown to be an internal language for dagger compact categories.

  15. Antibody response to a sterile filtered PPD tuberculin in M. bovis infected and M. bovis sensitized cattle.

    Science.gov (United States)

    Rennie, Bryan; Filion, Lionel G; Smart, Nonie

    2010-11-09

    Bovine tuberculosis, caused by Mycobacterium bovis, afflicts approximately 50 million cattle worldwide and is detected by the tuberculin skin test (TST). While it has long been recognized that purified protein derivative (PPD) tuberculin is composed of a mixture of M. bovis derived protein components, little is known about the quality, relative quantity and identity of the proteins that make up PPD tuberculin. We manufactured a sterile filtered PPD tuberculin (SF-PPD) from a nine-week-old M. bovis culture supernatant in order to characterise the culture filtrate proteins (CFP) which make up M. bovis PPD tuberculin and to compare the antibody response of M. bovis infected versus M. bovis sensitized cattle. SF-PPD resolved into approximately 200 discrete spots using two-dimensional polyacrylamide gel electrophoresis (2-DE) while fewer than 65 spots could be discerned from 2-DE gels of tuberculin derived from autoclaved culture supernatant. Two dimensional Western blot analyses indicated that sera from M. bovis sensitized cattle recognized additional SF-PPD antigens as compared to M. bovis infected cattle at seven weeks post infection/sensitization. However, application of a comparative tuberculin skin test resulted in an antibody boosting response to the same set of M. bovis CFPs in both the M. bovis infected and M. bovis sensitized cattle. We concluded that it is the heat sterilization of the M. bovis CFPs that causes severe structural changes to the M. bovis proteins. This work suggests that M. bovis infected cattle and cattle artificially sensitized to M. bovis with an injection of heat killed cells exhibit similar antibody responses to M. bovis antigens.

  16. Calculus and Geometry

    Indian Academy of Sciences (India)

    IAS Admin

    Sphere–Cylinder Theorem, vol- ume and surface area of the torus, volume and surface area of a slice of a solid sphere. The author earned his PhD degree in mathematics. (topology), in 2000, from. Panjab University,. Chandigarh and since then he has been teaching analysis, algebra, calculus and discrete mathematics at.

  17. On Functional Calculus Estimates

    NARCIS (Netherlands)

    Schwenninger, F.L.

    2015-01-01

    This thesis presents various results within the field of operator theory that are formulated in estimates for functional calculi. Functional calculus is the general concept of defining operators of the form $f(A)$, where f is a function and $A$ is an operator, typically on a Banach space. Norm

  18. Provability Calculus of Constructions

    DEFF Research Database (Denmark)

    Nyblad, Kasten

    This thesis presents a type system, Provability Calculus of Constructions (PCoC) that can be used for the formalization of logic. In a theorem prover based on the system, the user can extend the prover with new inference rules in a logically consistent manner. This is done by representing PCo...

  19. Calculus Courses' Assessment Data

    Science.gov (United States)

    Pauna, Matti

    2017-01-01

    In this paper we describe computer-aided assessment methods used in online Calculus courses and the data they produce. The online learning environment collects a lot of time-stamped data about every action a student makes. Assessment data can be harnessed into use as a feedback, predictor, and recommendation facility for students and instructors.…

  20. Duration Calculus: Logical Foundations

    DEFF Research Database (Denmark)

    Hansen, Michael Reichhardt; Chaochen, Zhou

    1997-01-01

    The Duration Calculus (abbreviated DC) represents a logical approach to formal design of real-time systems, where real numbers are used to model time and Boolean valued functions over time are used to model states and events of real-time systems. Since it introduction, DC has been applied to many...

  1. Giant vesical calculus

    African Journals Online (AJOL)

    Giant vesical calculus. A case report. H. H. LAUBSCHER. Summary. An exceptional case of bladder stone is presented. The case is unusual as regards the size of the stone and the fact that the patient did··not seek medical assistance much earlier, as this was readily avail- able. Furthermore, recovery after removal of the.

  2. Lacroix and the calculus

    CERN Document Server

    Domingues, João Caramalho

    2008-01-01

    Silvestre François Lacroix (Paris, 1765 - ibid., 1843) was a most influential mathematical book author. His most famous work is the three-volume Traité du calcul différentiel et du calcul intégral (1797-1800; 2nd ed. 1810-1819) – an encyclopedic appraisal of 18th-century calculus which remained the standard reference on the subject through much of the 19th century, in spite of Cauchy's reform of the subject in the 1820's. Lacroix and the Calculus is the first major study of Lacroix’s large Traité. It uses the unique and massive bibliography given by Lacroix to explore late 18th-century calculus, and the way it is reflected in Lacroix’s account. Several particular aspects are addressed in detail, including: the foundations of differential calculus, analytic and differential geometry, conceptions of the integral, and types of solutions of differential equations (singular/complete/general integrals, geometrical interpretations, and generality of arbitrary functions). Lacroix’s large Traité... was a...

  3. Invasion of erythrocytes by Babesia bovis

    NARCIS (Netherlands)

    Gaffar, Fasila Razzia

    2004-01-01

    In this thesis we investigated the invasion of erythrocytes taking place during the asexual erythrocytic blood stage of the apicomplexan parasites Babesia bovis parasite. Host cell invasion by apicomplexan parasites is a complex process requiring multiple receptor-ligand interactions, involving

  4. Bacteremia with the bovis group streptococci

    DEFF Research Database (Denmark)

    Marmolin, Ea S; Hartmeyer, Gitte N; Christensen, Jens Jørgen

    2016-01-01

    DNA sequencing of the intergenic spacer (ITS) region was used to identify 53 blood culture isolates that had previously been designated to the bovis group streptococci and clinical data was collected retrospectively from patients' records using a standardized protocol. ITS sequencing identified 19....... pasteurianus (58.7%) bacteremia calls for intensive investigation for underlying disease focusing on the pancreas and the hepatobiliary system....

  5. Ecology and pathogenicity of gastrointestinal Streptococcus bovis.

    Science.gov (United States)

    Herrera, Paul; Kwon, Young Min; Ricke, Steven C

    2009-01-01

    Streptococcus bovis is an indigenous resident in the gastrointestinal tracts of both humans and animals. S. bovis is one of the major causes of bacterial endocarditis and has been implicated in the incidence of human colon cancer, possibly due to chronic inflammatory response at the site of intestinal colonization. Certain feeding regimens in ruminants can lead to overgrowth of S. bovis in the rumen, resulting in the over-production of lactate and capsular polysaccharide causing acute ruminal acidosis and bloat, respectively. There are multiple strategies in controlling acute lactic acidosis and bloat. The incidence of the two diseases may be controlled by strict dietary management. Gradual introduction of grain-based diets and the feeding of coarsely chopped roughage decrease the incidence of the two disease entities. Ionophores, which have been used to enhance feed conversion and growth rate in cattle, have been shown to inhibit the growth of lactic acid bacteria in the rumen. Other methods of controlling lactic acid bacteria in the ruminal environment (dietary supplementation of long-chain fatty acids, induction of passive and active immune responses to the bacteria, and the use of lytic bacteriophages) have also been investigated. It is anticipated that through continued in-depth ecological analysis of S. bovis the characteristics responsible for human and animal pathogenesis would be sufficiently identified to a point where more effective control strategies for the control of this bacteria can be developed.

  6. Babesia bovis clones: biochemical and enzymatic characterization

    International Nuclear Information System (INIS)

    Rodriguez Camarillo, S.D.

    1985-01-01

    Studies were undertaken to generate additional knowledge of the biochemistry of Babesia bovis. A modified in vitro culture technique used for cloning B. bovis. This technique included a low oxygen concentration atmosphere (2%, O 2 , 5% CO 2 , 93% N 2 ) and 4 mm fluid level. Cultures initiated with one infected erythrocyte were maintained until parasitemias of positive wells reached 2% parasitemia. Primary clones were obtained and from these, nine clones were recloned twice and used for subsequent studies. A procedure was developed to concentrate and separate B. bovis merozoites and infected erythrocytes by Percoll density gradients. Merozoites separated at 1.087 g/ml specific density, whereas infected erythrocytes separated at 1.121 g/ml. Viability of purified parasites was not affected. Agarose gel electrophoresis was used to identify metabolic enzyme in B. bovis and B. bigemina. The enzymes LDH, GDH, GPI and HK were detected in both species. Molecular analysis by one and two-dimensional gel electrophoresis of proteins metabolically labeled with 35 S-methionine indicated that two clones, derived from the same field strain, were similar but not identical to the parent. Fewer proteins were observed in the parental strain. Growth of two 60-Co irradiated B. bovis clones indicated a dose-effect relationship. Growth of parasites exposed for the longest period was initially retarded but returned to normal growth after two or three subcultures. Cultures exposed for shorter periods were unaffected with respect to the rate of growth. Analysis of electrophoretic mobility of metabolic enzyme showed a change in migration pattern

  7. Finite-dimensional calculus

    International Nuclear Information System (INIS)

    Feinsilver, Philip; Schott, Rene

    2009-01-01

    We discuss topics related to finite-dimensional calculus in the context of finite-dimensional quantum mechanics. The truncated Heisenberg-Weyl algebra is called a TAA algebra after Tekin, Aydin and Arik who formulated it in terms of orthofermions. It is shown how to use a matrix approach to implement analytic representations of the Heisenberg-Weyl algebra in univariate and multivariate settings. We provide examples for the univariate case. Krawtchouk polynomials are presented in detail, including a review of Krawtchouk polynomials that illustrates some curious properties of the Heisenberg-Weyl algebra, as well as presenting an approach to computing Krawtchouk expansions. From a mathematical perspective, we are providing indications as to how to implement infinite terms Rota's 'finite operator calculus'.

  8. Multivariate calculus and geometry

    CERN Document Server

    Dineen, Seán

    2014-01-01

    Multivariate calculus can be understood best by combining geometric insight, intuitive arguments, detailed explanations and mathematical reasoning. This textbook has successfully followed this programme. It additionally provides a solid description of the basic concepts, via familiar examples, which are then tested in technically demanding situations. In this new edition the introductory chapter and two of the chapters on the geometry of surfaces have been revised. Some exercises have been replaced and others provided with expanded solutions. Familiarity with partial derivatives and a course in linear algebra are essential prerequisites for readers of this book. Multivariate Calculus and Geometry is aimed primarily at higher level undergraduates in the mathematical sciences. The inclusion of many practical examples involving problems of several variables will appeal to mathematics, science and engineering students.

  9. On paragrassmann differential calculus

    International Nuclear Information System (INIS)

    Filippov, A.T.; Isaev, A.P.; Kurdikov, A.B.

    1992-01-01

    The paper significantly extends and generalizes our previous paper. Here we discuss explicit general constructions for paragrassmann calculus with one and many variables. For one variable nondegenerate differentiation algebras are identified and shown to be equivalent to the algebra of (p+1)x(p+1) complex matrices. For many variables we give a general construction of the differentiation algebras. Some particular examples are related to the multiparametric quantum deformations of the harmonic oscillators. 18 refs

  10. Calculus III essentials

    CERN Document Server

    REA, Editors of

    2012-01-01

    REA's Essentials provide quick and easy access to critical information in a variety of different fields, ranging from the most basic to the most advanced. As its name implies, these concise, comprehensive study guides summarize the essentials of the field covered. Essentials are helpful when preparing for exams, doing homework and will remain a lasting reference source for students, teachers, and professionals. Calculus III includes vector analysis, real valued functions, partial differentiation, multiple integrations, vector fields, and infinite series.

  11. Boolean integral calculus

    Science.gov (United States)

    Tucker, Jerry H.; Tapia, Moiez A.; Bennett, A. Wayne

    1988-01-01

    The concept of Boolean integration is developed, and different Boolean integral operators are introduced. Given the changes in a desired function in terms of the changes in its arguments, the ways of 'integrating' (i.e. realizing) such a function, if it exists, are presented. The necessary and sufficient conditions for integrating, in different senses, the expression specifying the changes are obtained. Boolean calculus has applications in the design of logic circuits and in fault analysis.

  12. Pre-calculus essentials

    CERN Document Server

    Woodward, Ernest

    2012-01-01

    REA's Essentials provide quick and easy access to critical information in a variety of different fields, ranging from the most basic to the most advanced. As its name implies, these concise, comprehensive study guides summarize the essentials of the field covered. Essentials are helpful when preparing for exams, doing homework and will remain a lasting reference source for students, teachers, and professionals. Pre-Calculus reviews sets, numbers, operations and properties, coordinate geometry, fundamental algebraic topics, solving equations and inequalities, functions, trigonometry, exponents

  13. Understanding the calculus

    OpenAIRE

    Tall, David

    1985-01-01

    A number of significant changes have have occurred recently that give us a golden opportunity to review the teaching of calculus. The most obvious is the arrival of the microcomputer in the mathematics classroom, allowing graphic demonstrations and individual investigations into the mathematical ideas. But equally potent are new\\ud insights into mathematics and mathematics education that suggest new ways of approaching the subject.\\ud In this article I shall consider some of the difficulties ...

  14. The umbral calculus

    CERN Document Server

    Roman, Steven

    2005-01-01

    Geared toward upper-level undergraduates and graduate students, this elementary introduction to classical umbral calculus requires only an acquaintance with the basic notions of algebra and a bit of applied mathematics (such as differential equations) to help put the theory in mathematical perspective. Subjects include Sheffer sequences and operators and their adjoints, with numerous examples of associated and other sequences. Related topics encompass the connection constants problem and duplication formulas, the Lagrange inversion formula, operational formulas, inverse relations, and binomial

  15. Graded tensor calculus

    International Nuclear Information System (INIS)

    Scheunert, M.

    1982-10-01

    We develop a graded tensor calculus corresponding to arbitrary Abelian groups of degrees and arbitrary commutation factors. The standard basic constructions and definitions like tensor products, spaces of multilinear mappings, contractions, symmetrization, symmetric algebra, as well as the transpose, adjoint, and trace of a linear mapping, are generalized to the graded case and a multitude of canonical isomorphisms is presented. Moreover, the graded versions of the classical Lie algebras are introduced and some of their basic properties are described. (orig.)

  16. Calculus with vectors

    CERN Document Server

    Treiman, Jay S

    2014-01-01

    Calculus with Vectors grew out of a strong need for a beginning calculus textbook for undergraduates who intend to pursue careers in STEM. fields. The approach introduces vector-valued functions from the start, emphasizing the connections between one-variable and multi-variable calculus. The text includes early vectors and early transcendentals and includes a rigorous but informal approach to vectors. Examples and focused applications are well presented along with an abundance of motivating exercises. All three-dimensional graphs have rotatable versions included as extra source materials and may be freely downloaded and manipulated with Maple Player; a free Maple Player App is available for the iPad on iTunes. The approaches taken to topics such as the derivation of the derivatives of sine and cosine, the approach to limits, and the use of "tables" of integration have been modified from the standards seen in other textbooks in order to maximize the ease with which students may comprehend the material. Additio...

  17. Differential Calculus on Quantum Spheres

    OpenAIRE

    Welk, Martin

    1998-01-01

    We study covariant differential calculus on the quantum spheres S_q^2N-1. Two classification results for covariant first order differential calculi are proved. As an important step towards a description of the noncommutative geometry of the quantum spheres, a framework of covariant differential calculus is established, including a particular first order calculus obtained by factorization, higher order calculi and a symmetry concept.

  18. Introduction to the operational calculus

    CERN Document Server

    Berg, Lothar

    2013-01-01

    Introduction to the Operational Calculus is a translation of ""Einfuhrung in die Operatorenrechnung, Second Edition."" This book deals with Heaviside's interpretation, on the Laplace integral, and on Jan Mikusinki's fundamental work ""Operational Calculus."" Throughout the book, basic algebraic concepts appear as aids to understanding some relevant points of the subject. An important field for research in analysis is asymptotic properties. This text also discusses examples to show the potentialities in applying operational calculus that run beyond ordinary differential equations with constant

  19. Mycoplasma bovis: Mechanisms of Resistance and Trends in Antimicrobial Susceptibility.

    Science.gov (United States)

    Lysnyansky, Inna; Ayling, Roger D

    2016-01-01

    Mycoplasma bovis is a cell-wall-less bacterium and belongs to the class Mollicutes. It is the most important etiological agent of bovine mycoplasmoses in North America and Europe, causing respiratory disease, mastitis, otitis media, arthritis, and reproductive disease. Clinical disease associated with M. bovis is often chronic, debilitating, and poorly responsive to antimicrobial therapy, resulting in significant economic loss, the full extent of which is difficult to estimate. Until M. bovis vaccines are universally available, sanitary control measures and antimicrobial treatment are the only approaches that can be used in attempts to control M. bovis infections. However, in vitro studies show that many of the current M. bovis isolates circulating in Europe have high minimum inhibitory concentrations (MIC) for many of the commercially available antimicrobials. In this review we summarize the current MIC trends indicating the development of antimicrobial resistance in M. bovis as well as the known molecular mechanisms by which resistance is acquired.

  20. Mycoplasma bovis: mechanisms of resistance and trends in antimicrobial susceptibility

    Directory of Open Access Journals (Sweden)

    Inna eLysnyansky

    2016-04-01

    Full Text Available Mycoplasma bovis is a cell-wall-less bacterium and belongs to the class Mollicutes. It is the most important etiological agent of bovine mycoplasmoses in North America and Europe, causing respiratory disease, mastitis, otitis media, arthritis, and reproductive disease. Clinical disease associated with M. bovis is often chronic, debilitating, and poorly responsive to antimicrobial therapy, resulting in significant economic loss, the full extent of which is difficult to estimate. Until M. bovis vaccines are universally available, sanitary control measures and antimicrobial treatment are the only approaches that can be used in attempts to control M. bovis infections. However, in vitro studies show that many of the current M. bovis isolates circulating in Europe have high minimum inhibitory concentrations (MIC for many of the commercially available antimicrobials. In this review we summarize the current MIC trends indicating the development of antimicrobial resistance in M. bovis as well as the known molecular mechanisms by which resistance is acquired.

  1. Polynomial Calculus: Rethinking the Role of Calculus in High Schools

    Science.gov (United States)

    Grant, Melva R.; Crombie, William; Enderson, Mary; Cobb, Nell

    2016-01-01

    Access to advanced study in mathematics, in general, and to calculus, in particular, depends in part on the conceptual architecture of these knowledge domains. In this paper, we outline an alternative conceptual architecture for elementary calculus. Our general strategy is to separate basic concepts from the particular advanced techniques used in…

  2. Early Vector Calculus: A Path through Multivariable Calculus

    Science.gov (United States)

    Robertson, Robert L.

    2013-01-01

    The divergence theorem, Stokes' theorem, and Green's theorem appear near the end of calculus texts. These are important results, but many instructors struggle to reach them. We describe a pathway through a standard calculus text that allows instructors to emphasize these theorems. (Contains 2 figures.)

  3. Mycobacterium bovis in milk samples: a preliminary investigation using PCR

    International Nuclear Information System (INIS)

    Achel, D.G.; Gyamfi, O.K.; Broni, F.; Gomda, Y.; Brown, C.A.

    2007-01-01

    PCR was used to screen milk samples (n=41) for Mycobacterium bovis. DNA samples were obtained through concentration by 50% sucrose addition and centrifugation. Sixteen (16) samples (or 39%) were positive for M. Bovis DNA and the rest 25 (or 61%) were negative. All four kraals had some samples testing positive for M. bovis; the highest being 50% (5/10) and the lowest being 13% (2/15). (au)

  4. Proof Nets for Lambek Calculus

    NARCIS (Netherlands)

    Roorda, Dirk

    1992-01-01

    The proof nets of linear logic are adapted to the non-commutative Lambek calculus. A different criterion for soundness of proof nets is given, which gives rise to new algorithms for proof search. The order sensitiveness of the Lambek calculus is reflected by the planarity condition on proof nets;

  5. Fluorescence spectroscopy of dental calculus

    International Nuclear Information System (INIS)

    Bakhmutov, D; Gonchukov, S; Sukhinina, A

    2010-01-01

    The aim of the present study was to investigate the fluorescence properties of dental calculus in comparison with the properties of adjacent unaffected tooth structure using both lasers and LEDs in the UV-visible range for fluorescence excitation. The influence of calculus color on the informative signal is demonstrated. The optimal spectral bands of excitation and registration of the fluorescence are determined

  6. Fluorescence spectroscopy of dental calculus

    Science.gov (United States)

    Bakhmutov, D.; Gonchukov, S.; Sukhinina, A.

    2010-05-01

    The aim of the present study was to investigate the fluorescence properties of dental calculus in comparison with the properties of adjacent unaffected tooth structure using both lasers and LEDs in the UV-visible range for fluorescence excitation. The influence of calculus color on the informative signal is demonstrated. The optimal spectral bands of excitation and registration of the fluorescence are determined.

  7. The Calculus of a Vase

    Science.gov (United States)

    Scherger, Nicole

    2012-01-01

    Of the most universal applications in integral calculus are those involved with finding volumes of solids of revolution. These profound problems are typically taught with traditional approaches of the disk and shell methods, after which most calculus curriculums will additionally cover arc length and surfaces of revolution. Even in these visibly…

  8. Probabilistic Mu-Calculus

    DEFF Research Database (Denmark)

    Larsen, Kim Guldstrand; Mardare, Radu Iulian; Xue, Bingtian

    2016-01-01

    We introduce a version of the probabilistic µ-calculus (PMC) built on top of a probabilistic modal logic that allows encoding n-ary inequational conditions on transition probabilities. PMC extends previously studied calculi and we prove that, despite its expressiveness, it enjoys a series of good...... metaproperties. Firstly, we prove the decidability of satisfiability checking by establishing the small model property. An algorithm for deciding the satisfiability problem is developed. As a second major result, we provide a complete axiomatization for the alternation-free fragment of PMC. The completeness proof...

  9. Advanced calculus problem solver

    CERN Document Server

    REA, Editors of

    2012-01-01

    Each Problem Solver is an insightful and essential study and solution guide chock-full of clear, concise problem-solving gems. All your questions can be found in one convenient source from one of the most trusted names in reference solution guides. More useful, more practical, and more informative, these study aids are the best review books and textbook companions available. Nothing remotely as comprehensive or as helpful exists in their subject anywhere. Perfect for undergraduate and graduate studies.Here in this highly useful reference is the finest overview of advanced calculus currently av

  10. A Virtual Class Calculus

    DEFF Research Database (Denmark)

    Ernst, Erik; Ostermann, Klaus; Cook, William Randall

    2006-01-01

    Virtual classes are class-valued attributes of objects. Like virtual methods, virtual classes are defined in an object's class and may be redefined within subclasses. They resemble inner classes, which are also defined within a class, but virtual classes are accessed through object instances...... model for virtual classes has been a long-standing open question. This paper presents a virtual class calculus, vc, that captures the essence of virtual classes in these full-fledged programming languages. The key contributions of the paper are a formalization of the dynamic and static semantics of vc...

  11. Calculus problems and solutions

    CERN Document Server

    Ginzburg, Abraham

    2011-01-01

    Ideal for self-instruction as well as for classroom use, this text helps students improve their understanding and problem-solving skills in analysis, analytic geometry, and higher algebra. More than 1,200 problems appear in the text, with concise explanations of the basic notions and theorems to be used in their solution. Many are followed by complete answers; solutions for the others appear at the end of the book. Topics include sequences, functions of a single variable, limit of a function, differential calculus for functions of a single variable, fundamental theorems and applications of dif

  12. Calculus super review

    CERN Document Server

    2012-01-01

    Get all you need to know with Super Reviews! Each Super Review is packed with in-depth, student-friendly topic reviews that fully explain everything about the subject. The Calculus I Super Review includes a review of functions, limits, basic derivatives, the definite integral, combinations, and permutations. Take the Super Review quizzes to see how much you've learned - and where you need more study. Makes an excellent study aid and textbook companion. Great for self-study!DETAILS- From cover to cover, each in-depth topic review is easy-to-follow and easy-to-grasp - Perfect when preparing for

  13. Calculus of variations

    CERN Document Server

    Elsgolc, Lev D

    2007-01-01

    This concise text offers both professionals and students an introduction to the fundamentals and standard methods of the calculus of variations. In addition to surveys of problems with fixed and movable boundaries, it explores highly practical direct methods for the solution of variational problems.Topics include the method of variation in problems with fixed boundaries; variational problems with movable boundaries and other problems; sufficiency conditions for an extremum; variational problems of constrained extrema; and direct methods of solving variational problems. Each chapter features nu

  14. Leveraging Prior Calculus Study with Embedded Review

    Science.gov (United States)

    Nikolov, Margaret C.; Withers, Wm. Douglas

    2016-01-01

    We propose a new course structure to address the needs of college students with previous calculus study but no course validations as an alternative to repeating the first year of calculus. Students are introduced directly to topics from Calculus III unpreceded by a formal review of topics from Calculus I or II, but with additional syllabus time…

  15. A generalized nonlocal vector calculus

    Science.gov (United States)

    Alali, Bacim; Liu, Kuo; Gunzburger, Max

    2015-10-01

    A nonlocal vector calculus was introduced in Du et al. (Math Model Meth Appl Sci 23:493-540, 2013) that has proved useful for the analysis of the peridynamics model of nonlocal mechanics and nonlocal diffusion models. A formulation is developed that provides a more general setting for the nonlocal vector calculus that is independent of particular nonlocal models. It is shown that general nonlocal calculus operators are integral operators with specific integral kernels. General nonlocal calculus properties are developed, including nonlocal integration by parts formula and Green's identities. The nonlocal vector calculus introduced in Du et al. (Math Model Meth Appl Sci 23:493-540, 2013) is shown to be recoverable from the general formulation as a special example. This special nonlocal vector calculus is used to reformulate the peridynamics equation of motion in terms of the nonlocal gradient operator and its adjoint. A new example of nonlocal vector calculus operators is introduced, which shows the potential use of the general formulation for general nonlocal models.

  16. An operator calculus for surface and volume modeling

    Science.gov (United States)

    Gordon, W. J.

    1984-01-01

    The mathematical techniques which form the foundation for most of the surface and volume modeling techniques used in practice are briefly described. An outline of what may be termed an operator calculus for the approximation and interpolation of functions of more than one independent variable is presented. By considering the linear operators associated with bivariate and multivariate interpolation/approximation schemes, it is shown how they can be compounded by operator multiplication and Boolean addition to obtain a distributive lattice of approximation operators. It is then demonstrated via specific examples how this operator calculus leads to practical techniques for sculptured surface and volume modeling.

  17. Genetic variations among Mycoplasma bovis strains isolated from Danish cattle

    DEFF Research Database (Denmark)

    Kusiluka, L.J.M.; Kokotovic, Branko; Ojeniyi, B.

    2000-01-01

    The genetic heterogeneity of Mycoplasma bovis strains isolated in Denmark over a 17-year period was investigated. Forty-two field strains isolated from different geographic locations and specimens, including strains from 21 herds involved in two outbreaks of M. bovis-induced mastitis, and the type...

  18. Streptococcus bovis septicemia and meningitis associated with chronic radiation enterocolitis

    International Nuclear Information System (INIS)

    Jadeja, L.; Kantarjian, H.; Bolivar, R.

    1983-01-01

    We describe the first patient with simultaneous S bovis septicemia and meningitis associated with chronic radiation enterocolitis. This case underlines the value of a thorough gastrointestinal evaluation of all patients with S bovis infection, and the need for a neurologic investigation even with minor neurologic manifestations

  19. Mycobacterium bovis hip bursitis in a lung transplant recipient.

    Science.gov (United States)

    Dan, J M; Crespo, M; Silveira, F P; Kaplan, R; Aslam, S

    2016-02-01

    We present a report of extrapulmonary Mycobacterium bovis infection in a lung transplant recipient. M. bovis is acquired predominantly by zoonotic transmission, particularly from consumption of unpasteurized foods. We discuss epidemiologic exposure, especially as relates to the Mexico-US border, clinical characteristics, resistance profile, and treatment. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  20. Sensitivity of Mycobacterium bovis to common beef processing interventions

    Science.gov (United States)

    Objective. Mycobacterium bovis is the causative agent of bovine tuberculosis, a relevant zoonosis that can spread to humans through inhalation or by ingestion. M. bovis multiplies slowly, so infected animals may be sent to slaughter during the early stages of the disease before diagnosis and when ...

  1. Prevalence of Mycobacterium bovis in Cattle Slaughtered at Sokoto ...

    African Journals Online (AJOL)

    This study was undertaken to screen cattle slaughtered at the Sokoto Central Abattoir for antibodies against Mycobacterium bovis. By the lateral flow technique (immunochromatography), using monoclonal antibodies for M. bovis (BioNote, Inc. Gyeonggi-do, Korea) and by post mortem examination. A total of 194 slaughtered ...

  2. Transmissie van Mycobacterium bovis tussen mens en dier

    NARCIS (Netherlands)

    Vries, de G.; Beer, de J.; Bakker, D.; Soolingen, D.

    2015-01-01

    Nederland is officieel vrij van rundertuberculose. Toch komt af en toe nog Mycobacterium bovis-tuberculose voor bij relatief jonge autochtone Nederlanders. Ook zijn er recent nog wel boviene-uitbraken geweest. Dat roept de vraag op of er ook nu nog transmissie is van M.bovis tussen mens en dier.

  3. Seroprevalence of Mycoplasma bovis infection in dairy cows in ...

    African Journals Online (AJOL)

    Seroprevalence of Mycoplasma bovis infection in dairy cows in subtropical southern China. ... Dairy cows with the history of 5 pregnancies had the highest seroprevalence (33.3%). However, no statistically significant association was found between M. bovis infection and age or number of pregnancies (p > 0.05). All the ...

  4. The calculus a genetic approach

    CERN Document Server

    Toeplitz, Otto

    2007-01-01

    When first published posthumously in 1963, this book presented a radically different approach to the teaching of calculus.  In sharp contrast to the methods of his time, Otto Toeplitz did not teach calculus as a static system of techniques and facts to be memorized. Instead, he drew on his knowledge of the history of mathematics and presented calculus as an organic evolution of ideas beginning with the discoveries of Greek scholars, such as Archimedes, Pythagoras, and Euclid, and developing through the centuries in the work of Kepler, Galileo, Fermat, Newton, and Leibniz. Through this unique a

  5. Fluorescence detection of dental calculus

    Science.gov (United States)

    Gonchukov, S.; Biryukova, T.; Sukhinina, A.; Vdovin, Yu

    2010-11-01

    This work is devoted to the optimization of fluorescence dental calculus diagnostics in optical spectrum. The optimal wavelengths for fluorescence excitation and registration are determined. Two spectral ranges 620 - 645 nm and 340 - 370 nm are the most convenient for supra- and subgingival calculus determination. The simple implementation of differential method free from the necessity of spectrometer using was investigated. Calculus detection reliability in the case of simple implementation is higher than in the case of spectra analysis at optimal wavelengths. The use of modulated excitation light and narrowband detection of informative signal allows us to decrease essentially its diagnostic intensity even in comparison with intensity of the low level laser dental therapy.

  6. The Vectorial $\\lambda$-Calculus

    OpenAIRE

    Arrighi, Pablo; Díaz-Caro, Alejandro; Valiron, Benoît

    2013-01-01

    We describe a type system for the linear-algebraic $\\lambda$-calculus. The type system accounts for the linear-algebraic aspects of this extension of $\\lambda$-calculus: it is able to statically describe the linear combinations of terms that will be obtained when reducing the programs. This gives rise to an original type theory where types, in the same way as terms, can be superposed into linear combinations. We prove that the resulting typed $\\lambda$-calculus is strongly normalising and fea...

  7. Pre-Calculus For Dummies

    CERN Document Server

    Kuang, Yang

    2012-01-01

    The fun and easy way to learn pre-calculus Getting ready for calculus but still feel a bit confused? Have no fear. Pre-Calculus For Dummies is an un-intimidating, hands-on guide that walks you through all the essential topics, from absolute value and quadratic equations to logarithms and exponential functions to trig identities and matrix operations. With this guide's help you'll quickly and painlessly get a handle on all of the concepts - not just the number crunching - and understand how to perform all pre-calc tasks, from graphing to tackling proofs. You'll also get a new appreciation for

  8. Mathematics for physics with calculus

    CERN Document Server

    Das, Biman

    2005-01-01

    Designed for students who plan to take or who are presently taking calculus-based physics courses. This book will develop necessary mathematical skills and help students gain the competence to use precalculus, calculus, vector algebra, vector calculus, and the statistical analysis of experimental data. Students taking intermediate physics, engineering, and other science courses will also find the book useful-and will be able to use the book as a mathematical resource for these intermediate level courses. The book emphasizes primarily the use of mathematical techniques and mathematical concepts in Physics and does not go into their rigorous developments.

  9. Advanced calculus a transition to analysis

    CERN Document Server

    Dence, Thomas P

    2010-01-01

    Designed for a one-semester advanced calculus course, Advanced Calculus explores the theory of calculus and highlights the connections between calculus and real analysis -- providing a mathematically sophisticated introduction to functional analytical concepts. The text is interesting to read and includes many illustrative worked-out examples and instructive exercises, and precise historical notes to aid in further exploration of calculus. Ancillary list: * Companion website, Ebook- http://www.elsevierdirect.com/product.jsp?isbn=9780123749550 * Student Solutions Manual- To come * Instructor

  10. Stochastic calculus and applications

    CERN Document Server

    Cohen, Samuel N

    2015-01-01

    Completely revised and greatly expanded, the new edition of this text takes readers who have been exposed to only basic courses in analysis through the modern general theory of random processes and stochastic integrals as used by systems theorists, electronic engineers and, more recently, those working in quantitative and mathematical finance. Building upon the original release of this title, this text will be of great interest to research mathematicians and graduate students working in those fields, as well as quants in the finance industry. New features of this edition include: End of chapter exercises; New chapters on basic measure theory and Backward SDEs; Reworked proofs, examples and explanatory material; Increased focus on motivating the mathematics; Extensive topical index. "Such a self-contained and complete exposition of stochastic calculus and applications fills an existing gap in the literature. The book can be recommended for first-year graduate studies. It will be useful for all who intend to wo...

  11. Introduction to stochastic calculus

    CERN Document Server

    Karandikar, Rajeeva L

    2018-01-01

    This book sheds new light on stochastic calculus, the branch of mathematics that is most widely applied in financial engineering and mathematical finance. The first book to introduce pathwise formulae for the stochastic integral, it provides a simple but rigorous treatment of the subject, including a range of advanced topics. The book discusses in-depth topics such as quadratic variation, Ito formula, and Emery topology. The authors briefly address continuous semi-martingales to obtain growth estimates and study solution of a stochastic differential equation (SDE) by using the technique of random time change. Later, by using Metivier–Pellumail inequality, the solutions to SDEs driven by general semi-martingales are discussed. The connection of the theory with mathematical finance is briefly discussed and the book has extensive treatment on the representation of martingales as stochastic integrals and a second fundamental theorem of asset pricing. Intended for undergraduate- and beginning graduate-level stud...

  12. Waste pipe calculus extensions

    International Nuclear Information System (INIS)

    O'Connell, W.J.

    1979-01-01

    The waste pipe calculus provides a rapid method, using Laplace transforms, to calculate the transport of a pollutant such as nuclear waste, by a network of one-dimensional flow paths. The present note extends previous work as follows: (1) It provides an alternate approximation to the time-domain function (inverse Laplace transform) for the resulting transport. This algebraic approximation may be viewed as a simpler and more approximate model of the transport process. (2) It identifies two scalar quantities which may be used as summary consequence measures of the waste transport (or inversely, waste retention) system, and provides algebraic expressions for them. (3) It includes the effects of radioactive decay on the scalar quantity results, and further provides simplifying approximations for the cases of medium and long half-lives. This algebraic method can be used for quick approximate analyses of expected results, uncertainty and sensitivity, in evaluating selection and design choices for nuclear waste disposal systems

  13. Intuitionistic fuzzy calculus

    CERN Document Server

    Lei, Qian

    2017-01-01

    This book offers a comprehensive and systematic review of the latest research findings in the area of intuitionistic fuzzy calculus. After introducing the intuitionistic fuzzy numbers’ operational laws and their geometrical and algebraic properties, the book defines the concept of intuitionistic fuzzy functions and presents the research on the derivative, differential, indefinite integral and definite integral of intuitionistic fuzzy functions. It also discusses some of the methods that have been successfully used to deal with continuous intuitionistic fuzzy information or data, which are different from the previous aggregation operators focusing on discrete information or data. Mainly intended for engineers and researchers in the fields of fuzzy mathematics, operations research, information science and management science, this book is also a valuable textbook for postgraduate and advanced undergraduate students alike.

  14. Feynman integral calculus

    CERN Document Server

    Smirnov, Vladimir A

    2006-01-01

    The problem of evaluating Feynman integrals over loop momenta has existed from the early days of perturbative quantum field theory. The goal of the book is to summarize those methods for evaluating Feynman integrals that have been developed over a span of more than fifty years. `Feynman Integral Calculus' characterizes the most powerful methods in a systematic way. It concentrates on the methods that have been employed recently for most sophisticated calculations and illustrates them with numerous examples, starting from very simple ones and progressing to nontrivial examples. It also shows how to choose adequate methods and combine them in a non-trivial way. This is a textbook version of the previous book (Evaluating Feynman integrals, STMP 211) of the author. Problems and solutions have been included, Appendix G has been added, more details have been presented, recent publications on evaluating Feynman integrals have been taken into account and the bibliography has been updated.

  15. Mastite bovina por Mycoplasma bovis em rebanhos leiteiros Mastitis caused by Mycoplasma bovis in dairy cattle

    Directory of Open Access Journals (Sweden)

    Lucienne G. Pretto

    2001-12-01

    Full Text Available Foram examinadas 713 vacas de três rebanhos leiteiros localizados na região norte do Estado do Paraná e sudoeste do Estado de São Paulo, das quais 137 apresentaram mastite. Nas três propriedades foram detectados oito animais (1,12% com mastite clínica por Mycoplasma bovis. Destes animais, quatro tratados com oxitetraciclina e tilosina e três com enrofloxacina, não responderam ao tratamento e foram descartados no decorrer da lactação. Uma vaca medicada com enrofloxacina recuperou quase que totalmente a secreção láctea mas a eliminação de M. bovis persistiu por toda lactação. Esta vaca apresentou cura bacteriológica na lactação seguinte. O descarte dos animais positivos, monitora-mento bacteriológico e a aplicação correta das medidas de prevenção para as mastites contagiosas controlaram a disseminação de M. bovis nos rebanhos.In this study 713 cows were examined. The animals were from three dairy farms in northern Paraná and the southwest of the State of São Paulo. From these cows, 137 had mastitis. On the three farms, 8 cows (1.12% with Mycoplasma bovis mastitis were detected. Four were treated with tylosin and oxytetracyclin and three with enrofloxacin. There was no response to the treatments, and these animals were culled during the lactation period. One cow treated with enrofloxacin almost totally recovered milk production, but elimination of M. bovis continued during the lactation, and there was no bacteriological cure. This cow had a normal milk production in the next lactation period, without elimination of M. bovis. Culling of positive animals, the bacteriological study and correct application of preventive practices for contagious mastitis controlled the dissemination of M. bovis to other animals.

  16. A Formal Calculus for Categories

    DEFF Research Database (Denmark)

    Cáccamo, Mario José

    This dissertation studies the logic underlying category theory. In particular we present a formal calculus for reasoning about universal properties. The aim is to systematise judgements about functoriality and naturality central to categorical reasoning. The calculus is based on a language which...... extends the typed lambda calculus with new binders to represent universal constructions. The types of the languages are interpreted as locally small categories and the expressions represent functors. The logic supports a syntactic treatment of universality and duality. Contravariance requires a definition...... of universality generous enough to deal with functors of mixed variance. Ends generalise limits to cover these kinds of functors and moreover provide the basis for a very convenient algebraic manipulation of expressions. The equational theory of the lambda calculus is extended with new rules for the definitions...

  17. Synthesizing controllers from duration calculus

    DEFF Research Database (Denmark)

    Fränzle, Martin

    1996-01-01

    Duration Calculus is a logic for reasoning about requirements for real-time systems at a high level of abstraction from operational detail, which qualifies it as an interesting starting point for embedded controller design. Such a design activity is generally thought to aim at a control device...... the physical behaviours of which satisfy the requirements formula, i.e. the refinement relation between requirements and implementations is taken to be trajectory inclusion. Due to the abstractness of the vocabulary of Duration Calculus, trajectory inclusion between control requirements and controller designs...... for embedded controller design and exploit this fact for developing an automatic procedure for controller synthesis from specifications formalized in Duration Calculus. As far as we know, this is the first positive result concerning feasibility of automatic synthesis from dense-time Duration Calculus....

  18. Cartooning in Algebra and Calculus

    Science.gov (United States)

    Moseley, L. Jeneva

    2014-01-01

    This article discusses how teachers can create cartoons for undergraduate math classes, such as college algebra and basic calculus. The practice of cartooning for teaching can be helpful for communication with students and for students' conceptual understanding.

  19. Testicular calculus: A rare case.

    Science.gov (United States)

    Sen, Volkan; Bozkurt, Ozan; Demır, Omer; Tuna, Burcin; Yorukoglu, Kutsal; Esen, Adil

    2015-01-01

    Testicular calculus is an extremely rare case with unknown etiology and pathogenesis. To our knowledge, here we report the third case of testicular calculus. A 31-year-old man was admitted to our clinic with painful solid mass in left testis. After diagnostic work-up for a possible testicular tumour, he underwent inguinal orchiectomy and histopathologic examination showed a testicular calculus. Case hypothesis: Solid testicular lesions in young adults generally correspond to testicular cancer. Differential diagnosis should be done carefully. Future implications: In young adults with painful and solid testicular mass with hyperechogenic appearance on scrotal ultrasonography, testicular calculus must be kept in mind in differential diagnosis. Further reports on this topic may let us do more clear recommendations about the etiology and treatment of this rare disease.

  20. Differential calculus and its applications

    CERN Document Server

    Field, Michael J

    2013-01-01

    Based on undergraduate courses in advanced calculus, the treatment covers a wide range of topics, from soft functional analysis and finite-dimensional linear algebra to differential equations on submanifolds of Euclidean space. 1976 edition.

  1. Catwalk: First-Semester Calculus.

    Science.gov (United States)

    Speiser, Bob; Walter, Chuck

    1994-01-01

    Describes the use of time-lapse photographs of a running cat as a model to investigate the concepts of function and derivative in a college calculus course. Discusses student difficulties and implications for teachers. (MKR)

  2. Making an Interactive Calculus Textbook.

    Science.gov (United States)

    Larson, Timothy R.

    1995-01-01

    Presents a case study of the design and production of "Interactive Calculus," an interactive multimedia textbook. Discusses reasons for using multimedia textbooks; what an interactive textbook is; content, organization, graphic design, authoring and composition; and work flow. (AEF)

  3. Means and Variances without Calculus

    Science.gov (United States)

    Kinney, John J.

    2005-01-01

    This article gives a method of finding discrete approximations to continuous probability density functions and shows examples of its use, allowing students without calculus access to the calculation of means and variances.

  4. Mycobacterium bovis BCG mycobacteria--new application.

    Science.gov (United States)

    Kowalewicz-Kulbat, Magdalena; Pestel, Joël; Biet, Franck; Locht, Camille; Tonnel, André-Bernard; Druszczyńska, Magdalena; Rudnicka, Wiesława

    2006-01-01

    The polarized response of T helper-2 (Th2) lymphocytes to an allergen is considered to be the main cause of the pathogenesis of asthma. In this study, we asked a question whether M. bovis BCG mycobacteria which are known for the preferential stimulation of T helper-1 (Th1) immunity, diminish the effector functions of Th2 cells from allergic patients upon stimulation with a common house dust mite Der p-1 allergen. Our results allow a positive answer to this question. We demonstrate that BCG modulates the dendritic cell-dependent allergen presentation process and switches naive T lymphocytes towards an anti-allergic Th1 profile.

  5. Neutrosophic Precalculus and Neutrosophic Calculus

    OpenAIRE

    Florentin Smarandache

    2015-01-01

    Neutrosophic Analysis is a generalization of Set Analysis, which in its turn is a generalization of Interval Analysis. Neutrosophic Precalculus is referred to indeterminate staticity, while Neutrosophic Calculus is the mathematics of indeterminate change. The Neutrosophic Precalculus and Neutrosophic Calculus can be developed in many ways, depending on the types of indeterminacy one has and on the methods used to deal with such indeterminacy. In this book, the author presents a few examples o...

  6. Laparoscopic pyloromyotomy: comparing the arthrotomy knife to the Bovie blade.

    Science.gov (United States)

    Thomas, Priscilla G; Sharp, Nicole E; St Peter, Shawn D

    2014-07-01

    Laparoscopic pyloromyotomy was performed at our institution using an arthrotomy knife until it became unavailable in 2010. Thus, we adapted the use of the blunt Bovie tip, which can be used with or without electrocautery to perform the myotomy. This study compared the outcomes between using the arthrotomy knife versus the Bovie blade in laparoscopic pyloromyotomies. Retrospective review was performed on all laparoscopic pyloromyotomy patients from October 2007 to September 2012. Arthrotomy knife pyloromyotomy patients were compared with those performed with the Bovie blade. Patient demographics, diagnostic measurements, electrolyte levels, length of stay, operative time, and complications were compared. A total of 381 patients were included, with 191 in the arthrotomy group and 190 in the Bovie blade group. No significant differences existed between groups in age, weight, gender, pyloric dimensions, electrolyte levels, or length of stay. Mean operative times were 15.8±5.6 min with knife and 16.4±5.3 min for Bovie blade (P=0.24). In the arthrotomy knife group, there was one incomplete pyloromyotomy and one omental herniation. There was one wound infection in each group. Readmission rate was greater in the arthrotomy knife group (5.7%) versus the Bovie blade group (3.1%). The Bovie blade appears to offer no objective disadvantages compared with the arthrotomy knife when performing laparoscopic pyloromyotomy. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Mycobacterium bovis infection in domestic pigs in Great Britain.

    Science.gov (United States)

    Bailey, Suzanne S; Crawshaw, Timothy R; Smith, Noel H; Palgrave, Christopher J

    2013-11-01

    Mycobacterium bovis, the causative agent of bovine tuberculosis (TB), infects a wide range of wild and domestic mammals. Despite a control programme spanning decades, M. bovis infection levels in cattle in Great Britain (GB) have continued to rise over recent years. As the incidence of infection in cattle and wildlife may be linked to that in swine, data relating to infection of pigs identified at slaughter were examined in this study. Between 2007 and 2011, almost all M. bovis-infected pigs originated from farms in the South-West and West-Midland regions of England. The data suggest that pigs raised outdoors or on holdings with poor biosecurity may be more vulnerable to infection with M. bovis. In the majority of cases, the same strains of M. bovis were found in pigs and cattle, despite that fact that direct contact between these species was rarely observed. Genotyping and geographical mapping data indicated that some strains found in pigs may correlate better with those present in badgers, rather than cattle. In consequence, it is proposed that pigs may represent a useful sentinel for M. bovis infection in wildlife in GB. Given the potential implications of this infection for the pig industry, and for the on-going effort to control bovine TB, the importance of understanding the epidemiology and pathogenesis of M. bovis infection, as well as monitoring its prevalence, in pigs should not be underestimated. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.

  8. Significant Association of Streptococcus bovis with Malignant Gastrointestinal Diseases

    Directory of Open Access Journals (Sweden)

    Salah Shanan

    2011-01-01

    Full Text Available Streptococcus bovis is a Gram-positive bacterium causing serious human infections, including endocarditis and bacteremia, and is usually associated with underlying disease. The aims of the current study were to compare prevalence of the bacterium associated with malignant and nonmalignant gastrointestinal diseases and to determine the susceptibility of the isolated strains to different antimicrobial agents. The result showed that the prevalence of S. bovis in stool specimens from patients with malignant or with nonmalignant gastrointestinal diseases was statistically significant. This result may support the idea that there is correlation between S. bovis and the malignant gastrointestinal diseases.

  9. Differential calculus on deformed E(2) group

    International Nuclear Information System (INIS)

    Giller, S.; Gonera, C.; Kosinski, P.; Maslanka, P.

    1997-01-01

    Four dimensional bi-covariant differential *-calculus on quantum E(2) group is constructed. The relevant Lie algebra is obtained and covariant differential calculus on quantum plane is found. (author)

  10. The untyped stack calculus and Bohm's theorem

    Directory of Open Access Journals (Sweden)

    Alberto Carraro

    2013-03-01

    Full Text Available The stack calculus is a functional language in which is in a Curry-Howard correspondence with classical logic. It enjoys confluence but, as well as Parigot's lambda-mu, does not admit the Bohm Theorem, typical of the lambda-calculus. We present a simple extension of stack calculus which is for the stack calculus what Saurin's Lambda-mu is for lambda-mu.

  11. Fluorescence detection of dental calculus

    International Nuclear Information System (INIS)

    Gonchukov, S; Sukhinina, A; Vdovin, Yu; Biryukova, T

    2010-01-01

    This work is devoted to the optimization of fluorescence dental calculus diagnostics in optical spectrum. The optimal wavelengths for fluorescence excitation and registration are determined. Two spectral ranges 620 – 645 nm and 340 – 370 nm are the most convenient for supra- and subgingival calculus determination. The simple implementation of differential method free from the necessity of spectrometer using was investigated. Calculus detection reliability in the case of simple implementation is higher than in the case of spectra analysis at optimal wavelengths. The use of modulated excitation light and narrowband detection of informative signal allows us to decrease essentially its diagnostic intensity even in comparison with intensity of the low level laser dental therapy

  12. Essential AOP: The A Calculus

    DEFF Research Database (Denmark)

    De Fraine, Bruno; Ernst, Erik; Südholt, Mario

    2012-01-01

    Aspect-oriented programming (AOP) has produced interesting language designs, but also ad hoc semantics that needs clarification. We contribute to this clarification with a calculus that models essential AOP, both simpler and more general than existing formalizations. In AOP, advice may intercept......-oriented code. Two well-known pointcut categories, call and execution, are commonly considered similar.We formally expose their differences, and resolve the associated soundness problem. Our calculus includes type ranges, an intuitive and concise alternative to explicit type variables that allows advice...... to be polymorphic over intercepted methods. We use calculus parameters to cover type safety for a wide design space of other features. Type soundness is verified in Coq....

  13. On the fractional calculus of Besicovitch function

    International Nuclear Information System (INIS)

    Liang Yongshun

    2009-01-01

    Relationship between fractional calculus and fractal functions has been explored. Based on prior investigations dealing with certain fractal functions, fractal dimensions including Hausdorff dimension, Box dimension, K-dimension and Packing dimension is shown to be a linear function of order of fractional calculus. Both Riemann-Liouville fractional calculus and Weyl-Marchaud fractional derivative of Besicovitch function have been discussed.

  14. An AP Calculus Classroom Amusement Park

    Science.gov (United States)

    Ferguson, Sarah

    2016-01-01

    Throughout the school year, AP Calculus teachers strive to teach course content comprehensively and swiftly in an effort to finish all required material before the AP Calculus exam. As early May approaches and the AP Calculus test looms, students and teachers nervously complete lessons, assignments, and assessments to ensure student preparation.…

  15. Quantum mechanics and umbral calculus

    International Nuclear Information System (INIS)

    Lopez-Sendino, J E; Negro, J; Olmo, M A del; Salgado, E

    2008-01-01

    In this paper we present the first steps for obtaining a discrete Quantum Mechanics making use of the Umbral Calculus. The idea is to discretize the continuous Schroedinger equation substituting the continuous derivatives by discrete ones and the space-time continuous variables by well determined operators that verify some Umbral Calculus conditions. In this way we assure that some properties of integrability and symmetries of the continuous equation are preserved and also the solutions of the continuous case can be recovered discretized in a simple way. The case of the Schroedinger equation with a potential depending only in the space variable is discussed.

  16. Elementary calculus an infinitesimal approach

    CERN Document Server

    Keisler, H Jerome

    2012-01-01

    This first-year calculus book is centered around the use of infinitesimals, an approach largely neglected until recently for reasons of mathematical rigor. It exposes students to the intuition that originally led to the calculus, simplifying their grasp of the central concepts of derivatives and integrals. The author also teaches the traditional approach, giving students the benefits of both methods.Chapters 1 through 4 employ infinitesimals to quickly develop the basic concepts of derivatives, continuity, and integrals. Chapter 5 introduces the traditional limit concept, using approximation p

  17. Sequent Calculus and Equational Programming

    Directory of Open Access Journals (Sweden)

    Nicolas Guenot

    2015-07-01

    Full Text Available Proof assistants and programming languages based on type theories usually come in two flavours: one is based on the standard natural deduction presentation of type theory and involves eliminators, while the other provides a syntax in equational style. We show here that the equational approach corresponds to the use of a focused presentation of a type theory expressed as a sequent calculus. A typed functional language is presented, based on a sequent calculus, that we relate to the syntax and internal language of Agda. In particular, we discuss the use of patterns and case splittings, as well as rules implementing inductive reasoning and dependent products and sums.

  18. Applying π-Calculus to Practice

    DEFF Research Database (Denmark)

    Abendroth, Jorg

    2003-01-01

    The π-Calculus has been developed to reason about behavioural equivalence. Different notations of equivalence are defined in terms of process interactions, as well as the context of processes. There are various extensions of the π-Calculus, such as the SPI calculus, which has primitives...... modles are instantiated correctly. In this paper we will utilize the to π-Calculus reason about access control policies and mechanism. An equivalence of different policy implementations, as well as access control mechanism will be shown. Finally some experiences regarding the use of π-Calculus...

  19. A Calculus for Trust Management

    DEFF Research Database (Denmark)

    Carbone, Marco; Nielsen, Mogens; Sassone, Vladimiro

    2004-01-01

    principals to policies. We elect to formalise policies using a Datalog-like logic, and to express protocols in the process algebra style. This yields an expressive calculus very suitable for the global computing scenarios, and provides a formalisation of notions such as trust evolution. For ctm we define...

  20. Advanced calculus of several variables

    CERN Document Server

    Edwards, C H

    1995-01-01

    Modern conceptual treatment of multivariable calculus, emphasizing the interplay of geometry and analysis via linear algebra and the approximation of nonlinear mappings by linear ones. At the same time, ample attention is paid to the classical applications and computational methods. Hundreds of examples, problems and figures. 1973 edition.

  1. POGIL in the Calculus Classroom

    Science.gov (United States)

    Bénéteau, Catherine; Guadarrama, Zdenka; Guerra, Jill E.; Lenz, Laurie; Lewis, Jennifer E.; Straumanis, Andrei

    2017-01-01

    In this paper, we will describe the experience of the authors in using process-oriented guided inquiry learning (POGIL) in calculus at four institutions across the USA. We will briefly examine how POGIL compares to and fits in with other kinds of inquiry-based learning approaches. In particular, we will first discuss the unique structure of a…

  2. Portfolio Analysis for Vector Calculus

    Science.gov (United States)

    Kaplan, Samuel R.

    2015-01-01

    Classic stock portfolio analysis provides an applied context for Lagrange multipliers that undergraduate students appreciate. Although modern methods of portfolio analysis are beyond the scope of vector calculus, classic methods reinforce the utility of this material. This paper discusses how to introduce classic stock portfolio analysis in a…

  3. Reading the World with Calculus

    Science.gov (United States)

    Verzosa, Debbie

    2015-01-01

    It is now increasingly recognized that mathematics is not a neutral value-free subject. Rather, mathematics can challenge students' taken-for-granted realities and promote action. This article describes two issues, namely deforestation and income inequality. These were specifically chosen because they can be related to a range of calculus concepts…

  4. Constructivized Calculus in College Mathematics

    Science.gov (United States)

    Lawrence, Barbara Ann

    2012-01-01

    The purpose of this study is to present some of the classical concepts, definitions, and theorems of calculus from the constructivists' point of view in the spirit of the philosophies of L.E.J. Brouwer and Errett Bishop. This presentation will compare the classical statements to the constructivized statements. The method focuses on giving…

  5. Stochastic Pi-calculus Revisited

    DEFF Research Database (Denmark)

    Cardelli, Luca; Mardare, Radu Iulian

    2013-01-01

    We develop a version of stochastic Pi-calculus with a semantics based on measure theory. We dene the behaviour of a process in a rate environment using measures over the measurable space of processes induced by structural congruence. We extend the stochastic bisimulation to include the concept of...

  6. The fermion stochastic calculus I

    International Nuclear Information System (INIS)

    Streater, R.F.

    1984-01-01

    The author describes the stochastic calculus of quantum processes with fermions. After a description of the Clifford algebra as the csup(*)-algebra generated by spinor fields the damped harmonic oscillator with quantum noise is considered as example. Then the Clifford process is described. Finally the Ito-Clifford integral and the Ito-Clifford isometry are presented. (HSI)

  7. A "Model" Multivariable Calculus Course.

    Science.gov (United States)

    Beckmann, Charlene E.; Schlicker, Steven J.

    1999-01-01

    Describes a rich, investigative approach to multivariable calculus. Introduces a project in which students construct physical models of surfaces that represent real-life applications of their choice. The models, along with student-selected datasets, serve as vehicles to study most of the concepts of the course from both continuous and discrete…

  8. Calculus Student Descending a Staircase.

    Science.gov (United States)

    Mueller, William

    1999-01-01

    Common student attitudes toward reform methods are conveyed through the thoughts of a student leaving a multivariable calculus exam and musings range over textbooks, homework, workload, group work, writing, noncomputational problems, instructional problems, instructional styles, and classroom activities. (Author/ASK)

  9. The Pendulum and the Calculus.

    Science.gov (United States)

    Sworder, Steven C.

    A pair of experiments, appropriate for the lower division fourth semester calculus or differential equations course, are presented. The second order differential equation representing the equation of motion of a simple pendulum is derived. The period of oscillation for a particular pendulum can be predicted from the solution to this equation. As a…

  10. Multivariable calculus and differential geometry

    CERN Document Server

    Walschap, Gerard

    2015-01-01

    This text is a modern in-depth study of the subject that includes all the material needed from linear algebra. It then goes on to investigate topics in differential geometry, such as manifolds in Euclidean space, curvature, and the generalization of the fundamental theorem of calculus known as Stokes' theorem.

  11. Reasoning about objects using process calculus techniques

    DEFF Research Database (Denmark)

    Kleist, Josva

    This thesis investigates the applicability of techniques known from the world of process calculi to reason about properties of object-oriented programs. The investigation is performed upon a small object-oriented language - The Sigma-calculus of Abadi and Cardelli. The investigation is twofold: We......-calculus turns out to be insufficient. Based on our experiences, we present a translation of a typed imperative Sigma-calculus, which looks promising. We are able to provide simple proofs of the equivalence of different Sigma-calculus objects using this translation. We use a labelled transition system adapted...... to the Sigma-calculus to investigate the use of process calculi techniques directly on the Sigma-calculus. The results obtained are of a fairly theoretical nature. We investigate the connection between the operational and denotaional semantics for a typed functional Sigma-calculus. The result is that Abadi...

  12. The impact of taking a college pre-calculus course on students' college calculus performance

    Science.gov (United States)

    Sonnert, Gerhard; Sadler, Philip M.

    2014-11-01

    Poor performance on placement exams keeps many US students who pursue a STEM (science, technology, engineering, mathematics) career from enrolling directly in college calculus. Instead, they must take a pre-calculus course that aims to better prepare them for later calculus coursework. In the USA, enrollment in pre-calculus courses in two- and four-year colleges continues to grow, and these courses are well-populated with students who already took pre-calculus in high school. We examine student performance in college calculus, using regression discontinuity to estimate the effects of taking college pre-calculus or not, in a national US sample of 5507 students at 132 institutions. We find that students who take college pre-calculus do not earn higher calculus grades.

  13. Factors Associated with Success in College Calculus II

    Science.gov (United States)

    Rosasco, Margaret E.

    2013-01-01

    Students are entering college having earned credit for college Calculus 1 based on their scores on the College Board's Advanced Placement (AP) Calculus AB exam. Despite being granted credit for college Calculus 1, it is unclear whether these students are adequately prepared for college Calculus 2. College calculus classes are often taught from a…

  14. Prevalence of Mycobacterium bovis in some cattle breeds in the aids ...

    African Journals Online (AJOL)

    M. bovis was identified by growth rate, pigment production, colony and cell morphology and biochemical characteristics. A total of 41 heads of cattle comprising of 9 bulls and 32 cows from 7 breeds were positive for M. bovis. No isolate of M. bovis was obtained from Keteku breed and no seasonal distribution of the organism ...

  15. Targeted surface expression of an exogenous antigen in stably transfected babesia bovis

    Science.gov (United States)

    Babesia bovis is a tick-borne intraerythocytic protozoan responsible for acute disease in cattle which can be controlled by vaccination with attenuated B. bovis strains. Emerging B. bovis transfection technologies may increase the usefulness of these live vaccines. Here we propose using transfected ...

  16. Genetic characterization of Australian Mycoplasma bovis isolates through whole genome sequencing analysis

    DEFF Research Database (Denmark)

    Parker, Alysia M.; Shukla, Ankit; House, John K.

    2016-01-01

    Mycoplasma bovis is a major pathogen in cattle causing mastitis, arthritis and pneumonia. First isolated in Australian cattle in 1970, M. bovis has persisted causing serious disease in infected herds. To date, genetic analysis of Australian M. bovis isolates has not been performed. With whole gen...

  17. Mycobacterium bovis infection in humans and cats in same household, Texas, USA, 2012

    Science.gov (United States)

    Mycobacterium bovis infection of cats is exceedingly rare in non-endemic regions for bovine tuberculosis. This case study describes the diagnosis and clinical management of pulmonary M. bovis infection in two indoor-housed cats and their association with at least one M. bovis-infected human in Texas...

  18. Reggeon calculus at collider energies

    International Nuclear Information System (INIS)

    Pajares, C.; Varias, A.; Yepes, P.

    1983-01-01

    The phenomenology of the perturbative reggeon calculus at collider energies is studied. It is found that the graphs which were neglected at ISR energies are still negligeable at √s=540 GeV. The perturbative series for the total cross section still converges reasonably fast. The values of the different parameters which describe rightly the data up to ISR energies give rise to a total cross section of around 60 mb at √s=540 GeV. For these values, the corresponding low mass and high mass eikonal series converges much more slowly. The non perturbative reggeon calculus gives rise to a total cross section less than 60 mb. (orig.)

  19. Toward lattice fractional vector calculus

    Science.gov (United States)

    Tarasov, Vasily E.

    2014-09-01

    An analog of fractional vector calculus for physical lattice models is suggested. We use an approach based on the models of three-dimensional lattices with long-range inter-particle interactions. The lattice analogs of fractional partial derivatives are represented by kernels of lattice long-range interactions, where the Fourier series transformations of these kernels have a power-law form with respect to wave vector components. In the continuum limit, these lattice partial derivatives give derivatives of non-integer order with respect to coordinates. In the three-dimensional description of the non-local continuum, the fractional differential operators have the form of fractional partial derivatives of the Riesz type. As examples of the applications of the suggested lattice fractional vector calculus, we give lattice models with long-range interactions for the fractional Maxwell equations of non-local continuous media and for the fractional generalization of the Mindlin and Aifantis continuum models of gradient elasticity.

  20. Metric regularity and subdifferential calculus

    International Nuclear Information System (INIS)

    Ioffe, A D

    2000-01-01

    The theory of metric regularity is an extension of two classical results: the Lyusternik tangent space theorem and the Graves surjection theorem. Developments in non-smooth analysis in the 1980s and 1990s paved the way for a number of far-reaching extensions of these results. It was also well understood that the phenomena behind the results are of metric origin, not connected with any linear structure. At the same time it became clear that some basic hypotheses of the subdifferential calculus are closely connected with the metric regularity of certain set-valued maps. The survey is devoted to the metric theory of metric regularity and its connection with subdifferential calculus in Banach spaces

  1. Brownian motion and stochastic calculus

    CERN Document Server

    Karatzas, Ioannis

    1998-01-01

    This book is designed as a text for graduate courses in stochastic processes. It is written for readers familiar with measure-theoretic probability and discrete-time processes who wish to explore stochastic processes in continuous time. The vehicle chosen for this exposition is Brownian motion, which is presented as the canonical example of both a martingale and a Markov process with continuous paths. In this context, the theory of stochastic integration and stochastic calculus is developed. The power of this calculus is illustrated by results concerning representations of martingales and change of measure on Wiener space, and these in turn permit a presentation of recent advances in financial economics (option pricing and consumption/investment optimization). This book contains a detailed discussion of weak and strong solutions of stochastic differential equations and a study of local time for semimartingales, with special emphasis on the theory of Brownian local time. The text is complemented by a large num...

  2. Discrete calculus methods for counting

    CERN Document Server

    Mariconda, Carlo

    2016-01-01

    This book provides an introduction to combinatorics, finite calculus, formal series, recurrences, and approximations of sums. Readers will find not only coverage of the basic elements of the subjects but also deep insights into a range of less common topics rarely considered within a single book, such as counting with occupancy constraints, a clear distinction between algebraic and analytical properties of formal power series, an introduction to discrete dynamical systems with a thorough description of Sarkovskii’s theorem, symbolic calculus, and a complete description of the Euler-Maclaurin formulas and their applications. Although several books touch on one or more of these aspects, precious few cover all of them. The authors, both pure mathematicians, have attempted to develop methods that will allow the student to formulate a given problem in a precise mathematical framework. The aim is to equip readers with a sound strategy for classifying and solving problems by pursuing a mathematically rigorous yet ...

  3. Space complexity in polynomial calculus

    Czech Academy of Sciences Publication Activity Database

    Filmus, Y.; Lauria, M.; Nordström, J.; Ron-Zewi, N.; Thapen, Neil

    2015-01-01

    Roč. 44, č. 4 (2015), s. 1119-1153 ISSN 0097-5397 R&D Projects: GA AV ČR IAA100190902; GA ČR GBP202/12/G061 Institutional support: RVO:67985840 Keywords : proof complexity * polynomial calculus * lower bounds Subject RIV: BA - General Mathematics Impact factor: 0.841, year: 2015 http://epubs.siam.org/doi/10.1137/120895950

  4. Increasing prevalence of Mycoplasma bovis in Danish cattle

    DEFF Research Database (Denmark)

    Kusiluka, L.J.M.; Ojeniyi, B.; Friis, N.F.

    2000-01-01

    A study on the prevalence of mycoplasmas in pneumonic bovine lungs was performed on material submitted for diagnostic pul poses at the Danish Veterinary Laboratory, Copenhagen. Among the 50 examined cases 43 (86.0%) were found to be infected with mycoplasmas. The predominant mycoplasmas were...... Ureaplasma spp. (72.0%), M dispar (48.0%) and M. bovis (24.0%). Other mycoplasmas were M. bovirhinis (20.0%) and M. bovigenitalium (6.0%). Among the infected lungs multiple species infections were predominant (76.7%) over single species infections (23.3%) with M.dispar-Ureaplasma (25.6%), M. bovis......-Ureaplasma (18.6%) and M. dispar-M. bovirhinis-Ureaplasma (11.6%) infections being the most frequently encountered combinations. There appears to be an increasing prevalence of Al. bovis (24.0%) as compared to earlier reports (0.6-2.0%), thus calling fur special attention upon this mycoplasma. Pulsed field gel...

  5. Mycobacterium bovis meningitis in young Nigerian-born male

    DEFF Research Database (Denmark)

    Faurholt-Jepsen, Daniel; Lillebæk, Troels; Nielsen, Ming-Yuan

    2014-01-01

    In Denmark, tuberculous meningitis is rare. Central nervous system (CNS) involvement with Mycobacterium bovis is even rarer and has only been seen three times since 1992. We present a case of M. bovis meningitis in a previously healthy young Nigerian-born male, who had been exposed to unpasteurized...... dairy products in Nigeria but had no known contact with larger mammals. Before the development of meningitis, the patient had several contacts with the health system due to fever and non-specific symptoms. Finally, upon hospital admission, the patient was diagnosed with M. tuberculosis complex...... meningitis and treated empirically. After 13 days he was discharged without neurological sequelae. Later, the culture revealed M. bovis and treatment was adjusted accordingly....

  6. Adherence of Moraxella bovis to cell cultures of bovine origin.

    Science.gov (United States)

    Annuar, B O; Wilcox, G E

    1985-09-01

    The adherence of five strains of Moraxella bovis to cell cultures was investigated. M bovis adhered to cultures of bovine corneal epithelial and Madin-Darby bovine kidney cells but not to cell types of non-bovine origin. Both piliated and unpiliated strains adhered but piliated strains adhered to a greater extent than unpiliated strains. Antiserum against pili of one strain inhibited adherence of piliated strains but caused only slight inhibition of adherence to the unpiliated strains. Treatment of bacteria with magnesium chloride caused detachment of pili from the bacterial cell and markedly inhibited adherence of piliated strains but caused only slight inhibition of adherence by the unpiliated strains. The results suggested that adhesion of piliated strains to cell cultures was mediated via pili but that adhesins other than pili may be involved in the attachment of unpiliated strains of M bovis to cells.

  7. [Fluorescence control of dental calculus removal].

    Science.gov (United States)

    Bakhmutov, D N; Gonchukov, S A; Lonkina, T V; Sukhinina, A V

    2012-01-01

    The main condition of periodontitis prevention is the full calculus removal from the teeth surface. This procedure should be fulfilled without harming adjacent unaffected tooth tissues. Nevertheless the problem of sensitive and precise estimating of tooth-calculus interface exists and potential risk of hard tissue damage remains. In the frames of this work it was shown that fluorescence diagnostics during calculus removal can be successfully used for precise detection of tooth-calculus interface. In so doing the simple implementation of this method free from the necessity of spectrometer using can be employed. Such a simple implementation of calculus detection set-up can be aggregated with the devices of calculus removing (as ultrasonic or laser devices).

  8. The malliavin calculus and related topics

    CERN Document Server

    Nualart, David

    1995-01-01

    The Malliavin calculus (or stochastic calculus of variations) is an infinite-dimensional differential calculus on the Wiener space Originally, it was developed to prove a probabilistic proof to Hörmander's "sum of squares" theorem, but more recently it has found application in a variety of stochastic differential equation problems This monograph presents the main features of the Malliavin calculus and discusses in detail its connection with the anticipating stochastic calculus The author begins by developing analysis on the Wiener space, and then uses this to analyze the regularity of probability laws and to prove Hörmander's theorem Subsequent chapters apply the Malliavin calculus to anticipating stochastic differential equations and to studying the Markov property of solutions to stochastic differential equations with boundary conditions

  9. Regge calculus from discontinuous metrics

    International Nuclear Information System (INIS)

    Khatsymovsky, V.M.

    2003-01-01

    Regge calculus is considered as a particular case of the more general system where the linklengths of any two neighbouring 4-tetrahedra do not necessarily coincide on their common face. This system is treated as that one described by metric discontinuous on the faces. In the superspace of all discontinuous metrics the Regge calculus metrics form some hypersurface defined by continuity conditions. Quantum theory of the discontinuous metric system is assumed to be fixed somehow in the form of quantum measure on (the space of functionals on) the superspace. The problem of reducing this measure to the Regge hypersurface is addressed. The quantum Regge calculus measure is defined from a discontinuous metric measure by inserting the δ-function-like phase factor. The requirement that continuity conditions be imposed in a 'face-independent' way fixes this factor uniquely. The term 'face-independent' means that this factor depends only on the (hyper)plane spanned by the face, not on it's form and size. This requirement seems to be natural from the viewpoint of existence of the well-defined continuum limit maximally free of lattice artefacts

  10. Dental Calculus Arrest of Dental Caries

    OpenAIRE

    Keyes, Paul H.; Rams, Thomas E.

    2016-01-01

    Background An inverse relationship between dental calculus mineralization and dental caries demineralization on teeth has been noted in some studies. Dental calculus may even form superficial layers over existing dental caries and arrest their progression, but this phenomenon has been only rarely documented and infrequently considered in the field of Cariology. To further assess the occurrence of dental calculus arrest of dental caries, this study evaluated a large number of extracted human t...

  11. Jet-calculus approach including coherence effects

    International Nuclear Information System (INIS)

    Jones, L.M.; Migneron, R.; Narayanan, K.S.S.

    1987-01-01

    We show how integrodifferential equations typical of jet calculus can be combined with an averaging procedure to obtain jet-calculus-based results including the Mueller interference graphs. Results in longitudinal-momentum fraction x for physical quantities are higher at intermediate x and lower at large x than with the conventional ''incoherent'' jet calculus. These results resemble those of Marchesini and Webber, who used a Monte Carlo approach based on the same dynamics

  12. Time scales: from Nabla calculus to Delta calculus and vice versa via duality

    OpenAIRE

    Caputo, M. Cristina

    2009-01-01

    In this note we show how one can obtain results from the nabla calculus from results on the delta calculus and vice versa via a duality argument. We provide applications of the main results to the calculus of variations on time scales.

  13. A Calculus for Context-Awareness

    DEFF Research Database (Denmark)

    Zimmer, Pascal

    2005-01-01

    In order to answer the challenge of pervasive computing, we propose a new process calculus, whose aim is to describe dynamic systems composed of agents able to move and react differently depending on their location. This Context-Aware Calculus features a hierarchical structure similar to mobile...... ambients, and a generic multi-agent synchronization mechanism, inspired from the join-calculus. After general ideas and introduction, we review the full calculus' syntax and semantics, as well as some motivating examples, study its expressiveness, and show how the notion of computation itself can be made...

  14. A Higher-Order Calculus for Categories

    DEFF Research Database (Denmark)

    Cáccamo, Mario José; Winskel, Glynn

    2001-01-01

    A calculus for a fragment of category theory is presented. The types in the language denote categories and the expressions functors. The judgements of the calculus systematise categorical arguments such as: an expression is functorial in its free variables; two expressions are naturally isomorphic...... in their free variables. There are special binders for limits and more general ends. The rules for limits and ends support an algebraic manipulation of universal constructions as opposed to a more traditional diagrammatic approach. Duality within the calculus and applications in proving continuity are discussed...... with examples. The calculus gives a basis for mechanising a theory of categories in a generic theorem prover like Isabelle....

  15. A κ-symmetry calculus for superparticles

    International Nuclear Information System (INIS)

    Gauntlett, J.P.

    1991-01-01

    We develop a κ-symmetry calculus for the d=2 and d=3, N=2 massive superparticles, which enables us to construct higher order κ-invariant actions. The method relies on a reformulation of these models as supersymmetric sigma models that are invariant under local worldline superconformal transformations. We show that the κ-symmetry is embedded in the superconformal symmetry so that a calculus for the κ-symmetry is equivalent to a tensor calculus for the latter. We develop such a calculus without the introduction of a wordline supergravity multiplet. (orig.)

  16. Generalized vector calculus on convex domain

    Science.gov (United States)

    Agrawal, Om P.; Xu, Yufeng

    2015-06-01

    In this paper, we apply recently proposed generalized integral and differential operators to develop generalized vector calculus and generalized variational calculus for problems defined over a convex domain. In particular, we present some generalization of Green's and Gauss divergence theorems involving some new operators, and apply these theorems to generalized variational calculus. For fractional power kernels, the formulation leads to fractional vector calculus and fractional variational calculus for problems defined over a convex domain. In special cases, when certain parameters take integer values, we obtain formulations for integer order problems. Two examples are presented to demonstrate applications of the generalized variational calculus which utilize the generalized vector calculus developed in the paper. The first example leads to a generalized partial differential equation and the second example leads to a generalized eigenvalue problem, both in two dimensional convex domains. We solve the generalized partial differential equation by using polynomial approximation. A special case of the second example is a generalized isoperimetric problem. We find an approximate solution to this problem. Many physical problems containing integer order integrals and derivatives are defined over arbitrary domains. We speculate that future problems containing fractional and generalized integrals and derivatives in fractional mechanics will be defined over arbitrary domains, and therefore, a general variational calculus incorporating a general vector calculus will be needed for these problems. This research is our first attempt in that direction.

  17. Pre-calculus workbook for dummies

    CERN Document Server

    Kuang, Yang

    2011-01-01

    Get the confidence and math skills you need to get started with calculus Are you preparing for calculus? This hands-on workbook helps you master basic pre-calculus concepts and practice the types of problems you'll encounter in the course. You'll get hundreds of valuable exercises, problem-solving shortcuts, plenty of workspace, and step-by-step solutions to every problem. You'll also memorize the most frequently used equations, see how to avoid common mistakes, understand tricky trig proofs, and much more. Pre-Calculus Workbook For Dummies is the perfect tool for anyone who wa

  18. Dental Calculus Arrest of Dental Caries.

    Science.gov (United States)

    Keyes, Paul H; Rams, Thomas E

    An inverse relationship between dental calculus mineralization and dental caries demineralization on teeth has been noted in some studies. Dental calculus may even form superficial layers over existing dental caries and arrest their progression, but this phenomenon has been only rarely documented and infrequently considered in the field of Cariology. To further assess the occurrence of dental calculus arrest of dental caries, this study evaluated a large number of extracted human teeth for the presence and location of dental caries, dental calculus, and dental plaque biofilms. A total of 1,200 teeth were preserved in 10% buffered formal saline, and viewed while moist by a single experienced examiner using a research stereomicroscope at 15-25× magnification. Representative teeth were sectioned and photographed, and their dental plaque biofilms subjected to gram-stain examination with light microscopy at 100× magnification. Dental calculus was observed on 1,140 (95%) of the extracted human teeth, and no dental carious lesions were found underlying dental calculus-covered surfaces on 1,139 of these teeth. However, dental calculus arrest of dental caries was found on one (0.54%) of 187 evaluated teeth that presented with unrestored proximal enamel caries. On the distal surface of a maxillary premolar tooth, dental calculus mineralization filled the outer surface cavitation of an incipient dental caries lesion. The dental calculus-covered carious lesion extended only slightly into enamel, and exhibited a brown pigmentation characteristic of inactive or arrested dental caries. In contrast, the tooth's mesial surface, without a superficial layer of dental calculus, had a large carious lesion going through enamel and deep into dentin. These observations further document the potential protective effects of dental calculus mineralization against dental caries.

  19. Dental Calculus Arrest of Dental Caries

    Science.gov (United States)

    Keyes, Paul H.; Rams, Thomas E.

    2016-01-01

    Background An inverse relationship between dental calculus mineralization and dental caries demineralization on teeth has been noted in some studies. Dental calculus may even form superficial layers over existing dental caries and arrest their progression, but this phenomenon has been only rarely documented and infrequently considered in the field of Cariology. To further assess the occurrence of dental calculus arrest of dental caries, this study evaluated a large number of extracted human teeth for the presence and location of dental caries, dental calculus, and dental plaque biofilms. Materials and methods A total of 1,200 teeth were preserved in 10% buffered formal saline, and viewed while moist by a single experienced examiner using a research stereomicroscope at 15-25× magnification. Representative teeth were sectioned and photographed, and their dental plaque biofilms subjected to gram-stain examination with light microscopy at 100× magnification. Results Dental calculus was observed on 1,140 (95%) of the extracted human teeth, and no dental carious lesions were found underlying dental calculus-covered surfaces on 1,139 of these teeth. However, dental calculus arrest of dental caries was found on one (0.54%) of 187 evaluated teeth that presented with unrestored proximal enamel caries. On the distal surface of a maxillary premolar tooth, dental calculus mineralization filled the outer surface cavitation of an incipient dental caries lesion. The dental calculus-covered carious lesion extended only slightly into enamel, and exhibited a brown pigmentation characteristic of inactive or arrested dental caries. In contrast, the tooth's mesial surface, without a superficial layer of dental calculus, had a large carious lesion going through enamel and deep into dentin. Conclusions These observations further document the potential protective effects of dental calculus mineralization against dental caries. PMID:27446993

  20. Prevalence of Fasciola gigantica, Cysticercus bovis and some other ...

    African Journals Online (AJOL)

    Other disease conditions seen were splenomegaly, jaundice, and telangiactasis. Out of the 150cattle examined, 30 (20%) were infected or have disease. A total of 150 cattle comprising 116 males and 34 females were examined. The distribution of infections is as follows: 1(070%) was infected wth Cysticercus bovis, ...

  1. Comparative Proteomic Profiling of Mycobacterium bovis and BCG Vaccine Strains

    KAUST Repository

    Gao, Ge

    2013-09-01

    BCG is the only licensed human vaccine currently available against TB. Derived from a virulent strain of M. bovis, the vaccine was thought to have struck a balance between reduced virulence and preserved immunogenicity. Nowadays, BCG vaccine strains used in different countries and vaccination programs show clear variations in their genomes and immune protective properties. The aim of this study was to characterize the proteomic profile on Mycobacterium bovis and five BCG strains Pasteur, Tokyo, Danish, Phipps and Birkhaug by Tandem Mass Tag® (TMT®)-labeling quantitative proteomic approach. In total, 420 proteins were identified and 377 of them were quantitated for their relative abundance. We reported the number and relationship of differential expressed proteins in BCG strains compared to M. bovis and investigated their functions by bioinformatics analysis. Several interesting up-regulated and down-regulated protein targets were found. The identified proteins and their quantitative expression profiles provide a basis for further understanding of the cellular biology of M. bovis and BCG vaccine strains, and hopefully would assist in the design of better anti-TB vaccine and drugs.

  2. Verrucous endocarditis associated with Streptococcus bovis in mink (Mustela vison)

    DEFF Research Database (Denmark)

    Pedersen, Karl; Jørgensen, J.C.; Dietz, Hans-Henrik

    2003-01-01

    Between 1998 and 2001, mortalities due to verrucous endocarditis were experienced at several mink farms. Gram-positive cocci were isolated from the endocardium of all the animals examined but not always from other internal organs. Almost all the isolates were identified as Streptococcus bovis...

  3. Thematization of the Calculus Graphing Schema

    Science.gov (United States)

    Cooley, Laurel; Baker, Bernadette; Trigueros, Maria

    2003-01-01

    This article is the result of an investigation of students' conceptualizations of calculus graphing techniques after they had completed at least two semesters of calculus. The work and responses of 27 students to a series of questions that solicit information about the graphical implications of the first derivative, second derivative, continuity,…

  4. RAMAN-SPECTRA OF HUMAN DENTAL CALCULUS

    NARCIS (Netherlands)

    TSUDA, H; ARENDS, J

    1993-01-01

    Raman spectra of human dental calculus have been observed for the first time by use of micro-Raman spectroscopy. The spectral features of calculus were influenced easily by heating caused by laser irradiation. Therefore, the measurements were carried out at relatively low power (5 mW, 1-mu m spot

  5. Educating about Sustainability while Enhancing Calculus

    Science.gov (United States)

    Pfaff, Thomas J.

    2011-01-01

    We give an overview of why it is important to include sustainability in mathematics classes and provide specific examples of how to do this for a calculus class. We illustrate that when students use "Excel" to fit curves to real data, fundamentally important questions about sustainability become calculus questions about those curves. (Contains 5…

  6. Calculus and Success in a Business School

    Science.gov (United States)

    Kim, Dong-gook; Garcia, Fernando; Dey, Ishita

    2012-01-01

    Many business schools or colleges require calculus as a prerequisite for certain classes or for continuing to upper division courses. While there are many studies investigating the relationship between performance in calculus and performance in a single course, such as economics, statistics, and finance, there are very few studies investigating…

  7. Covariant differential calculus on the quantum hyperplane

    International Nuclear Information System (INIS)

    Wess, J.

    1991-01-01

    We develop a differential calculus on the quantum hyperplane covariant with respect to the action of the quantum group GL q (n). This is a concrete example of noncommutative differential geometry. We describe the general constraints for a noncommutative differential calculus and verify that the example given here satisfies all these constraints. We also discuss briefly the integration over the quantum plane. (orig.)

  8. Hybrid Logical Analyses of the Ambient Calculus

    DEFF Research Database (Denmark)

    Bolander, Thomas; Hansen, Rene Rydhof

    2010-01-01

    In this paper, hybrid logic is used to formulate three control flow analyses for Mobile Ambients, a process calculus designed for modelling mobility. We show that hybrid logic is very well-suited to express the semantic structure of the ambient calculus and how features of hybrid logic can...

  9. A Cross-National Study of Calculus

    Science.gov (United States)

    Chai, Jun; Friedler, Louis M.; Wolff, Edward F.; Li, Jun; Rhea, Karen

    2015-01-01

    The results from a cross-national study comparing calculus performance of students at East China Normal University (ECNU) in Shanghai and students at the University of Michigan before and after their first university calculus course are presented. Overall, ECNU significantly outperformed Michigan on both the pre- and post-tests, but the Michigan…

  10. An Introductory Calculus-Based Mechanics Investigation

    Science.gov (United States)

    Allen, Bradley

    2017-01-01

    One challenge for the introductory physics teacher is incorporating calculus techniques into the laboratory setting. It can be difficult to strike a balance between presenting an experimental task for which calculus is essential and making the mathematics accessible to learners who may be apprehensive about applying it. One-dimensional kinematics…

  11. Multiplicative calculus in biomedical image analysis

    NARCIS (Netherlands)

    Florack, L.M.J.; Assen, van H.C.

    2011-01-01

    We advocate the use of an alternative calculus in biomedical image analysis, known as multiplicative (a.k.a. non-Newtonian) calculus. It provides a natural framework in problems in which positive images or positive definite matrix fields and positivity preserving operators are of interest. Indeed,

  12. Areas and Volumes in Pre-Calculus

    Science.gov (United States)

    Jarrett, Joscelyn A.

    2008-01-01

    This article suggests the introduction of the concepts of areas bounded by plane curves and the volumes of solids of revolution in Pre-calculus. It builds on the basic knowledge that students bring to a pre-calculus class, derives a few more formulas, and gives examples of some problems on plane areas and the volumes of solids of revolution that…

  13. Improving student learning in calculus through applications

    Science.gov (United States)

    Young, C. Y.; Georgiopoulos, M.; Hagen, S. C.; Geiger, C. L.; Dagley-Falls, M. A.; Islas, A. L.; Ramsey, P. J.; Lancey, P. M.; Straney, R. A.; Forde, D. S.; Bradbury, E. E.

    2011-07-01

    Nationally only 40% of the incoming freshmen Science, Technology, Engineering and Mathematics (STEM) majors are successful in earning a STEM degree. The University of Central Florida (UCF) EXCEL programme is a National Science Foundation funded STEM Talent Expansion Programme whose goal is to increase the number of UCF STEM graduates. One of the key requirements for STEM majors is a strong foundation in Calculus. To improve student learning in calculus, the EXCEL programme developed two special courses at the freshman level called Applications of Calculus I (Apps I) and Applications of Calculus II (Apps II). Apps I and II are one-credit classes that are co-requisites for Calculus I and II. These classes are teams taught by science and engineering professors whose goal is to demonstrate to students where the calculus topics they are learning appear in upper level science and engineering classes as well as how faculty use calculus in their STEM research programmes. This article outlines the process used in producing the educational materials for the Apps I and II courses, and it also discusses the assessment results pertaining to this specific EXCEL activity. Pre- and post-tests conducted with experimental and control groups indicate significant improvement in student learning in Calculus II as a direct result of the application courses.

  14. A direct extension of Meller's calculus

    Directory of Open Access Journals (Sweden)

    E. L. Koh

    1982-01-01

    Full Text Available This paper extends the operational calculus of Meller for the operator Bα=t−αddttα+1ddt to the case where α∈(0,∞. The development is àla Mikusinski calculus and uses Meller's convolution process with a fractional derivative operator.

  15. A Snapshot of the Calculus Classroom

    Science.gov (United States)

    Weathers, Tony D.; Latterell, Carmen M.

    2003-01-01

    Essentially a focus group to discuss textbook related issues, a meeting of calculus instructors from a wide variety of environments was convened and sponsored by McGraw Hill to provide feedback on the current state of the calculus classroom. This paper provides a description of the group's discussions.

  16. Programming Language Concepts - The Lambda Calculus Approach

    NARCIS (Netherlands)

    Fokkinga, M.M.; Asveld, P.R.J.; Nijholt, Antinus

    1987-01-01

    The Lambda Calculus is a formal system, originally intended as a tool in the foundation of mathematics, but mainly used to study the concepts of algorithm and effective computability. Recently, the Lambda Calculus and related systems acquire attention from Computer Science for another reason too:

  17. Imagine Yourself in This Calculus Classroom

    Science.gov (United States)

    Bryan, Luajean

    2007-01-01

    The efforts to attract students to precalculus, trigonometry, and calculus classes became more successful at the author's school when projects-based classes were offered. Data collection from an untethered hot air balloon flight for calculus students was planned to maximize enrollment. The data were analyzed numerically, graphically, and…

  18. Laparoscopic Cholecystectomy in Chronic Calculus Cholecystitis

    Directory of Open Access Journals (Sweden)

    Prakash Sapkota

    2013-12-01

    Full Text Available Introduction: Laparoscopic cholecystectomy has clearly become the choice over open cholecystectomy in the treatment of hepatobiliary disease since its introduction by Mouret in 1987. This study evaluates a series of patients with chronic calculus cholecystitis who were treated with laparoscopic and open cholecystectomy and assesses the outcomes of both techniques. Objective: To evaluate the efficacy of laparoscopic vs open cholecystectomy in chronic calculus cholecystitis and establish the out-comes of this treatment modality at Lumbini Medical College and Teaching Hospital. Methods: This was a retrospective analysis over a one-year period (January 1, 2012 to December 31, 2012, per-formed by single surgeon at Lumbini Medical College and Teaching Hospital located midwest of Nepal. 166 patients underwent surgical treatment for chronic calculus cholecystitis. Patients included were only chronic calculus cholecystitis proven histopathologocally and the rest were excluded. Data was collected which included patients demographics, medical history, presentation, complications, conversion rates from laparoscopic. cholecystectomy to open cholecystectomy, operative and postoperative time. Results: Patients treated with laparoscopic cholecystectomy for chronic calculus cholecystitis had shorter operating times and length of stay compared to patients treated with open cholecystectomy for chronic calculus cholecystitis. Conversion rates were 3.54% in chronic calculus cholecystitis during the study period. Complications were also lower in patients who underwent laparoscopic cholecystectomy versus open cholecystectomy for cholelithiasis. Conclusions: Laparoscopic cholecystectomy appears to be a reliable, safe, and cost-effective treatment modality for chronic calculus cholecystitis.

  19. A type system for continuation calculus

    NARCIS (Netherlands)

    Geuvers, J.H.; Geraedts, W.; Geron, B.; Stegeren, van J.; Oliva, P.

    2014-01-01

    Continuation Calculus (CC), introduced by Geron and Geuvers, is a simple foundational model for functional computation. It is closely related to lambda calculus and term rewriting, but it has no variable binding and no pattern matching. It is Turing complete and evaluation is deterministic. Notions

  20. Matlab differential and integral calculus

    CERN Document Server

    Lopez, Cesar

    2014-01-01

    MATLAB is a high-level language and environment for numerical computation, visualization, and programming. Using MATLAB, you can analyze data, develop algorithms, and create models and applications. The language, tools, and built-in math functions enable you to explore multiple approaches and reach a solution faster than with spreadsheets or traditional programming languages, such as C/C++ or Java. MATLAB Differential and Integral Calculus introduces you to the MATLAB language with practical hands-on instructions and results, allowing you to quickly achieve your goals. In addition to givi

  1. Technical calculus with analytic geometry

    CERN Document Server

    Gersting, Judith L

    2010-01-01

    This well-thought-out text, filled with many special features, is designed for a two-semester course in calculus for technology students with a background in college algebra and trigonometry. The author has taken special care to make the book appealing to students by providing motivating examples, facilitating an intuitive understanding of the underlying concepts involved, and by providing much opportunity to gain proficiency in techniques and skills.Initial chapters cover functions and graphs, straight lines and conic sections, new coordinate systems, the derivative, using the derivative, in

  2. A course in advanced calculus

    CERN Document Server

    Borden, Robert S

    1997-01-01

    This remarkable undergraduate-level text offers a study in calculus that simultaneously unifies the concepts of integration in Euclidean space while at the same time giving students an overview of other areas intimately related to mathematical analysis. The author achieves this ambitious undertaking by shifting easily from one related subject to another. Thus, discussions of topology, linear algebra, and inequalities yield to examinations of innerproduct spaces, Fourier series, and the secret of Pythagoras. Beginning with a look at sets and structures, the text advances to such topics as lim

  3. Bridging the Vector Calculus Gap

    Science.gov (United States)

    Dray, Tevian; Manogue, Corinne

    2003-05-01

    As with Britain and America, mathematicians and physicists are separated from each other by a common language. In a nutshell, mathematics is about functions, but physics is about things. For the last several years, we have led an NSF-supported effort to "bridge the vector calculus gap" between mathematics and physics. The unifying theme we have discovered is to emphasize geometric reasoning, not (just) algebraic computation. In this talk, we will illustrate the language differences between mathematicians and physicists, and how we are trying reconcile them in the classroom. For further information about the project go to: http://www.physics.orst.edu/bridge

  4. Quantum chemistry and scientific calculus

    International Nuclear Information System (INIS)

    Gervais, H.P.

    1988-01-01

    The 1988 progress report of the Polytechnic School research team, concerning the quantum chemistry and the scientific calculus. The research program involves the following topics: the transition metals - carbon monoxide systems, which are a suitable model for the chemisorption phenomena; the introduction of the vibronic perturbations in the magnetic screen constants; the gauge invariance method (used in the calculation of the magnetic perturbations), extended to the case of the static or dynamic electrical polarizabilities. The published papers, the congress communications and the thesis are listed [fr

  5. Modern calculus and analytic geometry

    CERN Document Server

    Silverman, Richard A

    2012-01-01

    A self-contained text for an introductory course, this volume places strong emphasis on physical applications. Key elements of differential equations and linear algebra are introduced early and are consistently referenced, all theorems are proved using elementary methods, and numerous worked-out examples appear throughout. The highly readable text approaches calculus from the student's viewpoint and points out potential stumbling blocks before they develop. A collection of more than 1,600 problems ranges from exercise material to exploration of new points of theory - many of the answers are fo

  6. AP calculus AB/BC

    CERN Document Server

    Schwartz, Stu

    2013-01-01

    All Access for the AP® Calculus AB & BC Exams Book + Web + Mobile Everything you need to prepare for the Advanced Placement® exam, in a study system built around you! There are many different ways to prepare for an Advanced Placement® exam. What's best for you depends on how much time you have to study and how comfortable you are with the subject matter. To score your highest, you need a system that can be customized to fit you: your schedule, your learning style, and your current level of knowledge. This book, and the free online tools that come with it, will help you personalize your AP® Cal

  7. Enriching an effect calculus with linear types

    DEFF Research Database (Denmark)

    Egger, Jeff; Møgelberg, Rasmus Ejlers; Simpson, Alex

    2009-01-01

    We define an ``enriched effect calculus'' by conservatively extending  a type theory for computational effects with primitives from linear logic. By doing so, we obtain a generalisation of linear type theory, intended as a formalism for expressing linear aspects of effects. As a worked example, we...... formulate  linearly-used continuations in the enriched effect calculus. These are captured by a fundamental translation of the enriched effect calculus into itself, which extends existing call-by-value and call-by-name linearly-used CPS translations. We show that our translation is involutive. Full...... completeness results for the various linearly-used CPS translations  follow. Our main results, the conservativity of enriching the effect calculus with linear primitives, and the involution property of the fundamental translation, are proved using a category-theoretic semantics for the enriched effect calculus...

  8. Calculus and analysis in Euclidean space

    CERN Document Server

    Shurman, Jerry

    2016-01-01

    The graceful role of analysis in underpinning calculus is often lost to their separation in the curriculum. This book entwines the two subjects, providing a conceptual approach to multivariable calculus closely supported by the structure and reasoning of analysis. The setting is Euclidean space, with the material on differentiation culminating in the inverse and implicit function theorems, and the material on integration culminating in the general fundamental theorem of integral calculus. More in-depth than most calculus books but less technical than a typical analysis introduction, Calculus and Analysis in Euclidean Space offers a rich blend of content to students outside the traditional mathematics major, while also providing transitional preparation for those who will continue on in the subject. The writing in this book aims to convey the intent of ideas early in discussion. The narrative proceeds through figures, formulas, and text, guiding the reader to do mathematics resourcefully by marshaling the skil...

  9. Toward lattice fractional vector calculus

    International Nuclear Information System (INIS)

    Tarasov, Vasily E

    2014-01-01

    An analog of fractional vector calculus for physical lattice models is suggested. We use an approach based on the models of three-dimensional lattices with long-range inter-particle interactions. The lattice analogs of fractional partial derivatives are represented by kernels of lattice long-range interactions, where the Fourier series transformations of these kernels have a power-law form with respect to wave vector components. In the continuum limit, these lattice partial derivatives give derivatives of non-integer order with respect to coordinates. In the three-dimensional description of the non-local continuum, the fractional differential operators have the form of fractional partial derivatives of the Riesz type. As examples of the applications of the suggested lattice fractional vector calculus, we give lattice models with long-range interactions for the fractional Maxwell equations of non-local continuous media and for the fractional generalization of the Mindlin and Aifantis continuum models of gradient elasticity. (papers)

  10. A Calculus of Located Entities

    Directory of Open Access Journals (Sweden)

    Adriana Compagnoni

    2014-03-01

    Full Text Available We define BioScapeL, a stochastic pi-calculus in 3D-space. A novel aspect of BioScapeL is that entities have programmable locations. The programmer can specify a particular location where to place an entity, or a location relative to the current location of the entity. The motivation for the extension comes from the need to describe the evolution of populations of biochemical species in space, while keeping a sufficiently high level description, so that phenomena like diffusion, collision, and confinement can remain part of the semantics of the calculus. Combined with the random diffusion movement inherited from BioScape, programmable locations allow us to capture the assemblies of configurations of polymers, oligomers, and complexes such as microtubules or actin filaments. Further new aspects of BioScapeL include random translation and scaling. Random translation is instrumental in describing the location of new entities relative to the old ones. For example, when a cell secretes a hydronium ion, the ion should be placed at a given distance from the originating cell, but in a random direction. Additionally, scaling allows us to capture at a high level events such as division and growth; for example, daughter cells after mitosis have half the size of the mother cell.

  11. Giant calculus: review and report of a case.

    Science.gov (United States)

    Woodmansey, Karl; Severine, Anthony; Lembariti, Bakari S

    2013-01-01

    Dental calculus is a common oral finding. The term giant calculus is used to describe unusually large deposits of dental calculus. Several extreme cases have been reported in the dental literature. The specific etiology of these cases remains uncertain. This paper reviews previously reported cases, and presents another extreme example of giant calculus.

  12. Using Dynamic Software to Address Common College Calculus Stumbling Blocks

    Science.gov (United States)

    Seneres, Alice W.; Kerrigan, John A.

    2014-01-01

    There are specific topics in college calculus that can be major stumbling blocks for students. Having taught college calculus for four years to over a thousand students, we observed that even the students who have already taken pre-calculus or calculus during their high school careers had common misunderstandings. Students may remember a technique…

  13. Geometric calculus: a new computational tool for Riemannian geometry

    International Nuclear Information System (INIS)

    Moussiaux, A.; Tombal, P.

    1988-01-01

    We compare geometric calculus applied to Riemannian geometry with Cartan's exterior calculus method. The correspondence between the two methods is clearly established. The results obtained by a package written in an algebraic language and doing general manipulations on multivectors are compared. We see that the geometric calculus is as powerful as exterior calculus

  14. The Impact of Taking a College Pre-Calculus Course on Students' College Calculus Performance

    Science.gov (United States)

    Sonnert, Gerhard; Sadler, Philip M.

    2014-01-01

    Poor performance on placement exams keeps many US students who pursue a STEM (science, technology, engineering, mathematics) career from enrolling directly in college calculus. Instead, they must take a pre-calculus course that aims to better prepare them for later calculus coursework. In the USA, enrollment in pre-calculus courses in two- and…

  15. Motivation and Study Habits of College Calculus Students: Does Studying Calculus in High School Make a Difference?

    Science.gov (United States)

    Gibson, Megan

    2013-01-01

    Due in part to the growing popularity of the Advanced Placement program, an increasingly large percentage of entering college students are enrolling in calculus courses having already taken calculus in high school. Many students do not score high enough on the AP calculus examination to place out of Calculus I, and many do not take the…

  16. Relativistic collapse using Regge calculus: Pt. 1

    International Nuclear Information System (INIS)

    Dubal, M.R.; Leicester Univ.

    1989-01-01

    Regge calculus is used to simulate the dynamical collapse of model stars. In this paper we describe the general methodology of including a perfect fluid in dynamical Regge calculus spacetimes. The Regge-Einstein equations for spherical collapse are obtained and are then specialised to mimic a particular continuum gauge. The equivalent continuum problem is also set up. This is to be solved using standard numerical techniques (i.e. the method of finite difference). A subsequent paper will consider the solution of the equations presented here and will use the continuum problem for comparison purposes in order to check the Regge calculus results. (author)

  17. Area Regge calculus and continuum limit

    International Nuclear Information System (INIS)

    Khatsymovsky, V.M.

    2002-01-01

    Encountered in the literature generalisations of general relativity to independent area variables are considered, the discrete (generalised Regge calculus) and continuum ones. The generalised Regge calculus can be either with purely area variables or, as we suggest, with area tensor-connection variables. Just for the latter, in particular, we prove that in analogy with corresponding statement in ordinary Regge calculus (by Feinberg, Friedberg, Lee and Ren), passing to the (appropriately defined) continuum limit yields the generalised continuum area tensor-connection general relativity

  18. Applications of fractional calculus in physics

    CERN Document Server

    2000-01-01

    Fractional calculus is a collection of relatively little-known mathematical results concerning generalizations of differentiation and integration to noninteger orders. While these results have been accumulated over centuries in various branches of mathematics, they have until recently found little appreciation or application in physics and other mathematically oriented sciences. This situation is beginning to change, and there are now a growing number of research areas in physics which employ fractional calculus.This volume provides an introduction to fractional calculus for physicists, and co

  19. Recursive sequences in first-year calculus

    Science.gov (United States)

    Krainer, Thomas

    2016-02-01

    This article provides ready-to-use supplementary material on recursive sequences for a second-semester calculus class. It equips first-year calculus students with a basic methodical procedure based on which they can conduct a rigorous convergence or divergence analysis of many simple recursive sequences on their own without the need to invoke inductive arguments as is typically required in calculus textbooks. The sequences that are accessible to this kind of analysis are predominantly (eventually) monotonic, but also certain recursive sequences that alternate around their limit point as they converge can be considered.

  20. Pre-calculus workbook for dummies

    CERN Document Server

    Gilman, Michelle Rose; Neal, Karina

    2009-01-01

    Get the confidence and the math skills you need to get started with calculus! Are you preparing for calculus? This easy-to-follow, hands-on workbook helps you master basic pre-calculus concepts and practice the types of problems you'll encounter in your cour sework. You get valuable exercises, problem-solving shortcuts, plenty of workspace, and step-by-step solutions to every problem. You'll also memorize the most frequently used equations, see how to avoid common mistakes, understand tricky trig proofs, and much more. 100s of Problems! Detailed, fully worked-out solutions to problem

  1. AP calculus AB & BC crash course

    CERN Document Server

    Rosebush, J

    2012-01-01

    AP Calculus AB & BC Crash Course - Gets You a Higher Advanced Placement Score in Less Time Crash Course is perfect for the time-crunched student, the last-minute studier, or anyone who wants a refresher on the subject. AP Calculus AB & BC Crash Course gives you: Targeted, Focused Review - Study Only What You Need to Know Crash Course is based on an in-depth analysis of the AP Calculus AB & BC course description outline and actual AP test questions. It covers only the information tested on the exams, so you can make the most of your valuable study time. Written by experienced math teachers, our

  2. Restricted diversity of dental calculus methanogens over five centuries, France

    OpenAIRE

    Hong T. T. Huynh; Vanessa D. Nkamga; Michel Signoli; Stéfan Tzortzis; Romuald Pinguet; Gilles Audoly; Gérard Aboudharam; Michel Drancourt

    2016-01-01

    Methanogens are acknowledged archaeal members of modern dental calculus microbiota and dental pathogen complexes. Their repertoire in ancient dental calculus is poorly known. We therefore investigated archaea in one hundred dental calculus specimens collected from individuals recovered from six archaeological sites in France dated from the 14th to 19th centuries AD. Dental calculus was demonstrated by macroscopic and cone-beam observations. In 56 calculus specimens free of PCR inhibition, PCR...

  3. On Some Syntactic Properties of the Modalized Heyting Calculus

    OpenAIRE

    Muravitsky, Alexei

    2016-01-01

    We show that the modalized Heyting calculus introduced by Leo Esakia admits a normal axiomatization. Then, we prove that the inference rules $\\square\\alpha/\\alpha$ and $\\square\\alpha\\rightarrow\\alpha/\\alpha$ are admissible in this calculus. Finally, we show that this calculus and intuitionistic propositional calculus are assertorically equipollent, which leads to a variant of limited separation property for the modalized Heyting calculus.

  4. Generalized Multiparameters Fractional Variational Calculus

    Directory of Open Access Journals (Sweden)

    Om Prakash Agrawal

    2012-01-01

    Full Text Available This paper builds upon our recent paper on generalized fractional variational calculus (FVC. Here, we briefly review some of the fractional derivatives (FDs that we considered in the past to develop FVC. We first introduce new one parameter generalized fractional derivatives (GFDs which depend on two functions, and show that many of the one-parameter FDs considered in the past are special cases of the proposed GFDs. We develop several parts of FVC in terms of one parameter GFDs. We point out how many other parts could be developed using the properties of the one-parameter GFDs. Subsequently, we introduce two new two- and three-parameter GFDs. We introduce some of their properties, and discuss how they can be used to develop FVC. In addition, we indicate how these formulations could be used in various fields, and how the generalizations presented here can be further extended.

  5. Jet calculus beyond leading logarithms

    International Nuclear Information System (INIS)

    Kalinowski, J.; Konishi, K.; Taylor, T.R.

    1981-01-01

    It is shown that the evolution of hadronic jets produced in hard processes can be studied in terms of a simple parton branching picture, beyond the leading log approximation of QCD. The jet calculus is generalized to any given order of logs (but always to all orders of αsub(s)). We discuss the general structure of the formalism. Universality of jet evolution is discussed. We consider also a jet calorimetry measure and the multiplicity distribution of final states in a form which allows a systematic improvement of approximation. To the next-to-leading order, we prove the finiteness and elucidate the scheme dependence of parton subprocess probabilities. The physical inclusive cross section is shown to be scheme independent: next-to-leading results for e + e - → q (nonsinglet) + X agree with those of Curci and others. (orig.)

  6. The calculus lifesaver all the tools you need to excel at calculus

    CERN Document Server

    Banner, Adrian

    2009-01-01

    For many students, calculus can be the most mystifying and frustrating course they will ever take. The Calculus Lifesaver provides students with the essential tools they need not only to learn calculus, but to excel at it. All of the material in this user-friendly study guide has been proven to get results. The book arose from Adrian Banner's popular calculus review course at Princeton University, which he developed especially for students who are motivated to earn A's but get only average grades on exams. The complete course will be available for free on the Web in a series of

  7. Validation and use of an ELISA kit for the diagnosis of Babesia bovis in Cuba

    International Nuclear Information System (INIS)

    Blandino, T.; Alonso, M.; Barrera, M.; Mendoza, E.

    1998-01-01

    Babesia bovis, the most important etiological agent causing bovine babesiosis, is widely distributed in Cuba and affects mainly adult cattle. A survey of the prevalence of the disease in cattle using an ELISA kit (FAO/IAEA) revealed that 34.2% of the animals between 6 and 18 months of age were positive to Babesia bovis, whereas 69.9% on the cattle older than 18 months were positive. Antibodies to Babesia bovis were detected in 96.9% of calves vaccinated with an attenuated Babesia bovis vaccine. A good correlation was found between the results of ELISA kit with those from indirect immunofluorescence and immunoperoxidase tests developed in Cuba. (author)

  8. Molecular Detection of Anaplasma bovis in Cattle from Central Part of Iran

    Directory of Open Access Journals (Sweden)

    Vahid Noaman

    2010-09-01

    Full Text Available Anaplasma bovis is a leukocytotropic agent of bovine anaplasmosis and there is no available information about molecular study on this agent in cattle of Iran. In this study a total 150 cattle blood samples were collected from central part of Iran. The presence of A. bovis examined using light microscopic detection and species-specific nested polymerase chain reaction (nested-PCR based on 16S rRNA gene. Of the 150 cattle, 4 (2.66 % was positive for A. bovis by nested-PCR. These data is the first A. bovis DNA presence in cattle from central part of Iran.

  9. Impact of temperature and soil type on Mycobacterium bovis survival in the environment.

    Science.gov (United States)

    Barbier, Elodie; Rochelet, Murielle; Gal, Laurent; Boschiroli, Maria Laura; Hartmann, Alain

    2017-01-01

    Mycobacterium bovis, the causative agent of the bovine tuberculosis (bTB), mainly affects cattle, its natural reservoir, but also a wide range of domestic and wild mammals. Besides direct transmission via contaminated aerosols, indirect transmission of the M. bovis between wildlife and livestock might occur by inhalation or ingestion of environmental substrates contaminated through infected animal shedding. We monitored the survival of M. bovis in two soil samples chosen for their contrasted physical and-chemical properties (i.e. pH, clay content). The population of M. bovis spiked in sterile soils was enumerated by a culture-based method after 14, 30, 60, 90, 120 and 150 days of incubation at 4°C and 22°C. A qPCR based assay targeting the IS1561' locus was also performed to monitor M. bovis in both sterile and biotic spiked soils. The analysis of survival profiles using culture-based method showed that M. bovis survived longer at lower temperature (4°C versus 22°C) whereas the impact of soil characteristics on M. bovis persistence was not obvious. Furthermore, qPCR-based assay detected M. bovis for a longer period of time than the culture based method with higher gene copy numbers observed in sterile soils than in biotic ones. Impact of soil type on M. bovis persistence need to be deepened in order to fill the gap of knowledge concerning indirect transmission of the disease.

  10. Fractional Vector Calculus and Fractional Special Function

    OpenAIRE

    Li, Ming-Fan; Ren, Ji-Rong; Zhu, Tao

    2010-01-01

    Fractional vector calculus is discussed in the spherical coordinate framework. A variation of the Legendre equation and fractional Bessel equation are solved by series expansion and numerically. Finally, we generalize the hypergeometric functions.

  11. Newton Binomial Formulas in Schubert Calculus

    OpenAIRE

    Cordovez, Jorge; Gatto, Letterio; Santiago, Taise

    2008-01-01

    We prove Newton's binomial formulas for Schubert Calculus to determine numbers of base point free linear series on the projective line with prescribed ramification divisor supported at given distinct points.

  12. Brownian motion, martingales, and stochastic calculus

    CERN Document Server

    Le Gall, Jean-François

    2016-01-01

    This book offers a rigorous and self-contained presentation of stochastic integration and stochastic calculus within the general framework of continuous semimartingales. The main tools of stochastic calculus, including Itô’s formula, the optional stopping theorem and Girsanov’s theorem, are treated in detail alongside many illustrative examples. The book also contains an introduction to Markov processes, with applications to solutions of stochastic differential equations and to connections between Brownian motion and partial differential equations. The theory of local times of semimartingales is discussed in the last chapter. Since its invention by Itô, stochastic calculus has proven to be one of the most important techniques of modern probability theory, and has been used in the most recent theoretical advances as well as in applications to other fields such as mathematical finance. Brownian Motion, Martingales, and Stochastic Calculus provides a strong theoretical background to the reader interested i...

  13. Extending Stochastic Network Calculus to Loss Analysis

    Directory of Open Access Journals (Sweden)

    Chao Luo

    2013-01-01

    Full Text Available Loss is an important parameter of Quality of Service (QoS. Though stochastic network calculus is a very useful tool for performance evaluation of computer networks, existing studies on stochastic service guarantees mainly focused on the delay and backlog. Some efforts have been made to analyse loss by deterministic network calculus, but there are few results to extend stochastic network calculus for loss analysis. In this paper, we introduce a new parameter named loss factor into stochastic network calculus and then derive the loss bound through the existing arrival curve and service curve via this parameter. We then prove that our result is suitable for the networks with multiple input flows. Simulations show the impact of buffer size, arrival traffic, and service on the loss factor.

  14. Differential calculus for q-deformed twistors

    International Nuclear Information System (INIS)

    Akulov, V.P.; Duplij, S.A.; Chitov, V.V.

    1998-01-01

    Brief type of q-deformed differential calculus at light cone with using of twistor representation is suggested. Commutative relations between coordinates and moments are obtained. Considered quasiclassical limit gives exact form of vanish from mass shell

  15. Null-strut calculus. II. Dynamics

    International Nuclear Information System (INIS)

    Kheyfets, A.; LaFave, N.J.; Miller, W.A.

    1990-01-01

    In this paper, we continue from the preceding paper to develop a fully functional Regge calculus geometrodynamic algorithm from the null-strut-calculus construction. The developments discussed include (a) the identification of the Regge calculus analogue of the constraint and evolution equations on the null-strut lattice, (b) a description of the Minkowski solid geometry for the simplicial blocks of the null-strut lattice, (c) a description of the evolution algorithm for the geometrodynamic scheme and an analysis of its consistency, and (d) a presentation of the dynamical degrees of freedom for a simplicial hypersurface and the description of an initial-value prescription. To demonstrate qualitatively this new approach to geometrodynamics, we present the most simple application of null-strut calculus that we know of---the Friedmann cosmology using the three-boundary of a 600-cell simplicial polytope to model the simplicial hypersurface

  16. One Answer to "What Is Calculus?"

    Science.gov (United States)

    Shilgalis, Thomas W.

    1979-01-01

    A number of questions are posed that can be answered with the aid of calculus. These include best value problems, best shape problems, problems involving integration, and growth and decay problems. (MP)

  17. The contracted Bianchi identities in Regge calculus

    International Nuclear Information System (INIS)

    Williams, Ruth M

    2012-01-01

    In this note, we show explicitly how the linearized contracted Bianchi identities at a vertex in four-dimensional Regge calculus are related to a sum of the equations of motion for all the edges meeting at that vertex. (note)

  18. A primer on exterior differential calculus

    Directory of Open Access Journals (Sweden)

    Burton D.A.

    2003-01-01

    Full Text Available A pedagogical application-oriented introduction to the cal­culus of exterior differential forms on differential manifolds is presented. Stokes' theorem, the Lie derivative, linear con­nections and their curvature, torsion and non-metricity are discussed. Numerous examples using differential calculus are given and some detailed comparisons are made with their tradi­tional vector counterparts. In particular, vector calculus on R3 is cast in terms of exterior calculus and the traditional Stokes' and divergence theorems replaced by the more powerful exterior expression of Stokes' theorem. Examples from classical continuum mechanics and spacetime physics are discussed and worked through using the language of exterior forms. The numerous advantages of this calculus, over more traditional ma­chinery, are stressed throughout the article. .

  19. From Calculus to Wavelets: ANew Mathematical Technique

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 2; Issue 4. From Calculus to Wavelets: A New Mathematical Technique Wavelet Analysis Physical Properties. Gerald B Folland. General Article Volume 2 Issue 4 April 1997 pp 25-37 ...

  20. Introductory analysis a deeper view of calculus

    CERN Document Server

    Bagby, Richard J

    2000-01-01

    Introductory Analysis addresses the needs of students taking a course in analysis after completing a semester or two of calculus, and offers an alternative to texts that assume that math majors are their only audience. By using a conversational style that does not compromise mathematical precision, the author explains the material in terms that help the reader gain a firmer grasp of calculus concepts.* Written in an engaging, conversational tone and readable style while softening the rigor and theory* Takes a realistic approach to the necessary and accessible level of abstraction for the secondary education students* A thorough concentration of basic topics of calculus* Features a student-friendly introduction to delta-epsilon arguments * Includes a limited use of abstract generalizations for easy use* Covers natural logarithms and exponential functions* Provides the computational techniques often encountered in basic calculus

  1. The origins of Cauchy's rigorous calculus

    CERN Document Server

    Grabiner, Judith V

    2005-01-01

    This text examines the reinterpretation of calculus by Augustin-Louis Cauchy and his peers in the 19th century. These intellectuals created a collection of well-defined theorems about limits, continuity, series, derivatives, and integrals. 1981 edition.

  2. Algorithms, The λ Calculus and Programming

    Indian Academy of Sciences (India)

    IAS Admin

    developed a model to understand ... Hence the ¸ calculus also served as an alternate model ...... Practical programming using usual languages based on .... and return values as. 'answers'. This style of programming that emerges is therefore.

  3. Mycobacterium bovis: realities and challenges for the veterinary biopharmaceutical industry

    Directory of Open Access Journals (Sweden)

    Aníbal Domínguez Odio

    2016-01-01

    Full Text Available Mycobacterium bovis is the main etiological agent of bovine tuberculosis, bacterial diseases of world distribution, chronicle, of easy transmission, debilitating, zoonotic and antropozoonotic that affects any organ and which can be presented without symptoms On this base, it was carried out a study with the objective of approaching the current state and the scientific-technological projections for the prevention and diagnosis of the bovine tuberculosis, caused by M. bovis. It was demonstrated that the 45.09% of the original articles on inmunoprophylaxis against bacteria, registered in the Scopus database and contextualised until principles of 2014, were focused toward M. bovis. In spite of the advances in molecular biology and the hopes deposited in the Ag85A, Rv0287, Rv0288, Rv0251c, MPB70, MPB83, ESAT-6 and CFP-10 molecules, jointly with their combinations, it will continue absent in the market an effective, safety and differentiating vaccine; as well as a robust DIVA diagnosis system. It can be concluded that in the next 5 years, an officially recognized vacinal formulation will continue absent and that the tuberculin test in spite of its weaknesses will continue being the main tool of surveillance.

  4. Bovine Tuberculosis (Mycobacterium bovis) in Wildlife in Spain

    Science.gov (United States)

    Aranaz, Alicia; de Juan, Lucía; Montero, Natalia; Sánchez, Celia; Galka, Margarita; Delso, Consuelo; Álvarez, Julio; Romero, Beatriz; Bezos, Javier; Vela, Ana I.; Briones, Victor; Mateos, Ana; Domínguez, Lucas

    2004-01-01

    Mycobacterium bovis infection in wildlife and feral species is a potential source of infection for livestock and a threat to protected and endangered species. The aim of this study was to identify Spanish wild animal species infected with M. bovis through bacteriological culture and spacer oligonucleotide typing (spoligotyping) of isolates for epidemiological purposes. This study included samples from red deer (Cervus elaphus), fallow deer (Dama dama), wild boar (Sus scrofa), Iberian lynx (Lynx pardina), hare (Lepus europaeus), and cattle (Bos taurus). They were collected in several geographical areas that were selected for their unique ecological value and/or known relationships between wildlife and livestock. In the areas included in this survey, M. bovis strains with the same spoligotyping pattern were found infecting several wild species and livestock, which indicates an epidemiological link. A locally predominant spoligotype was found in these areas. Better understanding of the transmission and distribution of disease in these populations will permit more precise targeting of control measures. PMID:15184440

  5. Infection by Mycobacterium bovis in a dog from Brazil

    Directory of Open Access Journals (Sweden)

    Vivianne Cambuí Figueiredo Rocha

    Full Text Available Abstract Tuberculosis (TB is a chronic disease caused by bacteria belonging to the Mycobacterium tuberculosis complex (MtbC. This disease rarely affects dogs. Canine infections are usually caused by M. tuberculosis. Mycobacterium bovis infections are rare in dogs and associated with consumption of raw milk or contaminated products. Here, we report a Boxer dog who had a M. bovis infection and was admitted to a Brazilian veterinary hospital with a presumptive diagnosis of chronic ehrlichiosis. Despite receiving treatment for chronic ehrlichiosis, it progressed to death. TB was diagnosed during post-mortem examinations using histopathological analysis. Ziehl-Neelsen staining revealed acid-fast bacilli in the kidneys, liver, mesentery, and a mass adhered to the liver. Further, PCR-restriction analysis was performed to identify mycobacteria in the samples. A restriction profile compatible with MtbC was found in the lungs. In addition, PCR-based MtbC typing deletions at different loci of chromosome 9 enabled the identification of M. bovis in the lungs. Therefore, it is very essential to perform differential diagnosis of TB in dogs with non-specific clinical signs and who do not respond to treatment, particularly those who had been in contact with TB-infected cattle or owners. Further, we highlight the use of molecular methods for the identification of bacilli, improving the diagnosis and aiding epidemiological studies.

  6. Infection due to Mycobacterium bovis in common variable immunodeficiency

    Directory of Open Access Journals (Sweden)

    Diana Andrea Herrera-Sánchez

    2015-02-01

    Full Text Available Common variable immunodeficiency (CVID is an heterogeneous group of disorders characterized by impaired antibody production. It shows a wide spectrum of manifestations including severe and recurrent respiratory infections (Streptococcus pneumoniae, Haemophilus and gastrointestinal (Campylobacter jejuni, rotavirus and Giardia lamblia. Viral infections caused by herpes zoster, cytomegalovirus (CMV and hepatitis C are rare. The opportunistic agents such as CMV, Pneumocystis jirovecii, cryptococcus and atypical mycobacteria have been reported as isolated cases. This paper reports the case of a 38-year-old female patient, who began six years before with weight loss of 7 kg in six months, fatigue, weakness, sweating, fever and abdominal pain. Furthermore, patient had intestinal obstruction and abdominal CT showed mesenteric lymph growth. The mesenteric lymph node biopsy revealed positives Mycobacterium PCR, Ziehl-Neelsen staining and culture for M. bovis. In the laparotomy postoperative period was complicated with nosocomial pneumonia, requiring mechanical ventilation and tracheostomy. Two years later, she developed right renal abscess that required surgical drainage, once again with a positive culture for Mycobacterium bovis. She was referred to highly specialized hospital and we documented panhypogammaglobulinemia and lymphopenia. Secondary causes of hypogammaglobulinemia were ruled out and common variable immunodeficiency (CVID was confirmed, we started IVIG replacement. Four years later she developed mixed cellularity Hodgkin’s lymphoma. Until today she continues with IVIG and chemotherapy. This report of a patient with CVID and Mycobacterium bovis infection, a unusual association, shows the cellular immunity susceptibility in this immunodeficiency, additional to the humoral defect.

  7. Generalized Cartan Calculus in general dimension

    Science.gov (United States)

    Wang, Yi-Nan

    2015-07-01

    We develop the generalized Cartan Calculus for the groups and SO(5 , 5). They are the underlying algebraic structures of d = 9 , 7 , 6 exceptional field theory, respectively. These algebraic identities are needed for the "tensor hierarchy" structure in exceptional field theory. The validity of Poincaré lemmas in this new differential geometry is also discussed. Finally we explore some possible extension of the generalized Cartan calculus beyond the exceptional series.

  8. Sandboxing in a Distributed Pi-Calculus

    DEFF Research Database (Denmark)

    Hüttel, Hans; Kühnrich, Morten

    2006-01-01

    This paper presents an extension of the Dpi-calculus due to Hennessy and Riely with constructs for signing and authenticating code and for sandboxing. A sort system, built on Milner's sort systems for the polyadic pi-calculus, is presented and proven sound with respect to an error predicate which...... ensures that errors do not occur outside sandboxes and that authentication and migration only happen when allowed. Futhermore a weak subject reduction result involving partial well sortedness is presented....

  9. Area Regge calculus and discontinuous metrics

    International Nuclear Information System (INIS)

    Wainwright, Chris; Williams, Ruth M

    2004-01-01

    Taking the triangle areas as independent variables in the theory of Regge calculus can lead to ambiguities in the edge lengths, which can be interpreted as discontinuities in the metric. We construct solutions to area Regge calculus using a triangulated lattice and find that on a spacelike or timelike hypersurface no such discontinuity can arise. On a null hypersurface however, we can have such a situation and the resulting metric can be interpreted as a so-called refractive wave

  10. Łukasiewicz mu-Calculus

    Directory of Open Access Journals (Sweden)

    Matteo Mio

    2013-08-01

    Full Text Available The paper explores properties of Łukasiewicz mu-calculus, a version of the quantitative/probabilistic modal mu-calculus containing both weak and strong conjunctions and disjunctions from Łukasiewicz (fuzzy logic. We show that this logic encodes the well-known probabilistic temporal logic PCTL. And we give a model-checking algorithm for computing the rational denotational value of a formula at any state in a finite rational probabilistic nondeterministic transition system.

  11. A Graph Calculus for Predicate Logic

    Directory of Open Access Journals (Sweden)

    Paulo A. S. Veloso

    2013-03-01

    Full Text Available We introduce a refutation graph calculus for classical first-order predicate logic, which is an extension of previous ones for binary relations. One reduces logical consequence to establishing that a constructed graph has empty extension, i. e. it represents bottom. Our calculus establishes that a graph has empty extension by converting it to a normal form, which is expanded to other graphs until we can recognize conflicting situations (equivalent to a formula and its negation.

  12. A calculus for attribute-based communication

    DEFF Research Database (Denmark)

    Alrahman, Yehia Abd; De Nicola, Rocco; Loreti, Michele

    2015-01-01

    The notion of attribute-based communication seems promising to model and analyse systems with huge numbers of interacting components that dynamically adjust and combine their behaviour to achieve specific goals. A basic process calculus, named AbC, is introduced that has as primitive construct...... of how well-established process calculi could be encoded into AbC is given by considering the translation into AbC of a proto-typical π-calculus process....

  13. Superconformal tensor calculus in five dimensions

    International Nuclear Information System (INIS)

    Fujita, Tomoyuki; Ohashi, Keisuke

    2001-01-01

    We present a full superconformal tensor calculus in five spacetime dimensions in which the Weyl multiplet has 32 Bose plus 32 Fermi degrees of freedom. It is derived using dimensional reduction from the 6D superconformal tensor calculus. We present two types of 32+32 Weyl multiplets, a vector multiplet, linear multiplet, hypermultiplet and nonlinear multiplet. Their superconformal transformation laws and the embedding and invariant action formulas are given. (author)

  14. A phenomenological calculus of Wiener description space.

    Science.gov (United States)

    Richardson, I W; Louie, A H

    2007-10-01

    The phenomenological calculus is a categorical example of Robert Rosen's modeling relation. This paper is an alligation of the phenomenological calculus and generalized harmonic analysis, another categorical example. Our epistemological exploration continues into the realm of Wiener description space, in which constitutive parameters are extended from vectors to vector-valued functions of a real variable. Inherent in the phenomenology are fundamental representations of time and nearness to equilibrium.

  15. Endoscopic vs. tactile evaluation of subgingival calculus.

    Science.gov (United States)

    Osborn, Joy B; Lenton, Patricia A; Lunos, Scott A; Blue, Christine M

    2014-08-01

    Endoscopic technology has been developed to facilitate imagery for use during diagnostic and therapeutic phases of periodontal care. The purpose of this study was to compare the level of subgingival calculus detection using a periodontal endoscope with that of conventional tactile explorer in periodontitis subjects. A convenience sample of 26 subjects with moderate periodontitis in at least 2 quadrants was recruited from the University of Minnesota School of Dentistry to undergo quadrant scaling and root planing. One quadrant from each subject was randomized for tactile calculus detection alone and the other quadrant for tactile detection plus the Perioscope ™ (Perioscopy Inc., Oakland, Cali). A calculus index on a 0 to 3 score was performed at baseline and at 2 post-scaling and root planing visits. Sites where calculus was detected at visit 1 were retreated. T-tests were used to determine within-subject differences between Perioscope™ and tactile measures, and changes in measures between visits. Significantly more calculus was detected using the Perioscope™ vs. tactile explorer for all 3 subject visits (pcalculus detection from baseline to visit 1 were statistically significant for both the Perioscope™ and tactile quadrants (pcalculus detection from visit 1 to visit 2 was only significant for the Perioscope™ quadrant (pcalculus at this visit. It was concluded that the addition of a visual component to calculus detection via the Perioscope™ was most helpful in the re-evaluation phase of periodontal therapy. Copyright © 2014 The American Dental Hygienists’ Association.

  16. The efficacy of selective calculus ablation at 400 nm: comparison to conventional calculus removal methods

    Science.gov (United States)

    Schoenly, Joshua E.; Seka, Wolf; Romanos, Georgios; Rechmann, Peter

    A desired outcome of scaling and root planing is the complete removal of calculus and infected root tissue and preservation of healthy cementum for rapid healing of periodontal tissues. Conventional periodontal treatments for calculus removal, such as hand instrument scaling and ultrasonic scaling, often deeply scrape the surface of the underlying hard tissue and may leave behind a smear layer. Pulsed lasers emitting at violet wavelengths (specifically, 380 to 400 nm) are a potential alternative treatment since they can selectively ablate dental calculus without ablating pristine hard tissue (i.e., enamel, cementum, and dentin). In this study, light and scanning electron microscopy are used to compare and contrast the efficacy of in vitro calculus removal for several conventional periodontal treatments (hand instruments, ultrasonic scaler, and Er:YAG laser) to calculus removal with a frequency-doubled Ti:sapphire (λ = 400 nm). After calculus removal, enamel and cementum surfaces are investigated for calculus debris and damage to the underlying hard tissue surface. Compared to the smear layer, grooves, and unintentional hard tissue removal typically found using these conventional treatments, calculus removal using the 400-nm laser is complete and selective without any removal of pristine dental hard tissue. Based on these results, selective ablation from the 400-nm laser appears to produce a root surface that would be more suitable for successful healing of periodontal tissues.

  17. On the Presentation of Pre-Calculus and Calculus Topics: An Alternate View

    Science.gov (United States)

    Davydov, Aleksandr; Sturm-Beiss, Rachel

    2008-01-01

    The orders of presentation of pre-calculus and calculus topics, and the notation used, deserve careful study as they affect clarity and ultimately students' level of understanding. We introduce an alternate approach to some of the topics included in this sequence. The suggested alternative is based on years of teaching in colleges within and…

  18. Electronic Algebra and Calculus Tutor

    Directory of Open Access Journals (Sweden)

    Larissa Fradkin

    2012-06-01

    Full Text Available Modern undergraduates join science and engineering courses with poorer mathematical background than most contemporaries of the current faculty had when they were freshers. The problem is very acute in the United Kingdom but more and more countries adopt less resource intensive models of teaching and the problem spreads. University tutors and lecturers spend more and more time covering the basics. However, most of them still rely on traditional methods of delivery which presuppose that learners have a good memory and considerable time to practice, so that they can memorize disjointed facts and discover for themselves various connections between the underlying concepts. These suppositions are particularly unrealistic when dealing with a large number of undergraduates who are ordinary learners with limited mathematics background. The first author has developed a teaching system that allows such adult learners achieve relatively deep learning of mathematics – and remarkably quickly – through a teacher-guided (often called Socratic dialog, which aims at the frequent reinforcement of basic mathematical abstractions through Eulerian sequencing. These ideas have been applied to create a prototype of a Cognitive Mathematics Tutoring System aimed at teaching basic mathematics to University freshers., an electronic Personal Algebra and Calculus Tutor (e- PACT.

  19. Polymorphisms of twenty regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis

    Science.gov (United States)

    Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans or animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and the other members o...

  20. Molecular characterization of Mycobacterium bovis strains isolated from cattle slaughtered at two abattoirs in Algeria

    Directory of Open Access Journals (Sweden)

    Ouzrout Rachid

    2009-01-01

    Full Text Available Abstract Background Bovine Tuberculosis is prevalent in Algeria despite governmental attempts to control the disease. The objective of this study was to conduct, for the first time, molecular characterization of a population sample of Mycobacterium bovis strains isolated from slaughter cattle in Algeria. Between August and November 2007, 7250 animals were consecutively screened at the abattoirs of Algiers and Blida. In 260 animals, gross visible granulomatous lesions were detected and put into culture. Bacterial isolates were subsequently analysed by molecular methods. Results Altogether, 101 bacterial strains from 100 animals were subjected to molecular characterization. M. bovis was isolated from 88 animals. Other bacteria isolated included one strain of M. caprae, four Rhodococcus equi strains, three Non-tuberculous Mycobacteria (NTM and five strains of other bacterial species. The M. bovis strains isolated showed 22 different spoligotype patterns; four of them had not been previously reported. The majority of M. bovis strains (89% showed spoligotype patterns that were previously observed in strains from European cattle. Variable Number of Tandem Repeat (VNTR typing supported a link between M. bovis strains from Algeria and France. One spoligotype pattern has also been shown to be frequent in M. bovis strains from Mali although the VNTR pattern of the Algerian strains differed from the Malian strains. Conclusion M. bovis infections account for a high amount of granulomatous lesions detected in Algerian slaughter cattle during standard meat inspection at Algiers and Blida abattoir. Molecular typing results suggested a link between Algerian and European strains of M. bovis.

  1. Patterns and processes of Mycobacterium bovis evolution revealed by phylogenomic analyses

    Science.gov (United States)

    Mycobacterium bovis is an important animal pathogen worldwide that parasitizes wild and domesticated vertebrate livestock as well as humans. A comparison of the five M. bovis complete genomes from UK, South Korea, Brazil and USA revealed four novel large-scale structural variations of at least 2,000...

  2. Cerebral ischemia caused by Streptococcus bovis aortic endocarditis: case report Isquemia cerebral causada por endocardite aórtica pelo Streptococcus bovis: relato de caso

    Directory of Open Access Journals (Sweden)

    Leopoldo Santos-Neto

    2005-09-01

    Full Text Available Cerebral ischemic processes associated with infective endocarditis caused by Streptococcus bovis are rare; only 2 cases having been reported. Here we report a case of a 50-year-old man with S. bovis endocarditis who presented signs of frontal, parietal and occipital lobe cerebral ischemia. This is the first case reported in which the presence of hemianopsia preceded the endocarditis diagnosis. Initially, the clinical manifestations suggested a systemic vasculitis. Later, vegetating lesions were identified in the aortic valve and S. bovis grew in blood cultures. Antibiotic use and aortic valve replacement eliminated the infection and ceased thromboembolic events. A videocolonoscopy examination revealed no mucosal lesions as a portal of entry in this case, although such lesions have been encountered in up to 70% of reported cases of S. bovis endocarditis.A associação de isquemia cerebral e endocardite por Streptococcus bovis é um evento raro, tendo sido publicados apenas 2 casos anteriormente. Nós relatamos o caso de um homem de 50 anos com endocardite por S. bovis que apresentou sinais isquêmicos nos lobos frontal, parietal e occipital. Este é o primeiro caso em que a hemianopsia precedeu o diagnóstico de endocardite. Inicialmente, o quadro foi confundido com vasculite. Posteriormente, foi confirmada a presença de vegetações na válvula aórtica e a hemocultura identificou S. bovis. Os eventos tromboembólicos foram controlados com o uso de antibióticos e a troca da válvula aórtica. Estudo videocolonoscópico não identificou nenhuma lesão, apesar de lesões colônicas serem descritas em até 70% dos casos de indivíduos com endocardite por S. bovis.

  3. Ancient DNA analysis of dental calculus.

    Science.gov (United States)

    Weyrich, Laura S; Dobney, Keith; Cooper, Alan

    2015-02-01

    Dental calculus (calcified tartar or plaque) is today widespread on modern human teeth around the world. A combination of soft starchy foods, changing acidity of the oral environment, genetic pre-disposition, and the absence of dental hygiene all lead to the build-up of microorganisms and food debris on the tooth crown, which eventually calcifies through a complex process of mineralisation. Millions of oral microbes are trapped and preserved within this mineralised matrix, including pathogens associated with the oral cavity and airways, masticated food debris, and other types of extraneous particles that enter the mouth. As a result, archaeologists and anthropologists are increasingly using ancient human dental calculus to explore broad aspects of past human diet and health. Most recently, high-throughput DNA sequencing of ancient dental calculus has provided valuable insights into the evolution of the oral microbiome and shed new light on the impacts of some of the major biocultural transitions on human health throughout history and prehistory. Here, we provide a brief historical overview of archaeological dental calculus research, and discuss the current approaches to ancient DNA sampling and sequencing. Novel applications of ancient DNA from dental calculus are discussed, highlighting the considerable scope of this new research field for evolutionary biology and modern medicine. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Regularization of positive definite matrix fields based on multiplicative calculus

    NARCIS (Netherlands)

    Florack, L.M.J.; Bruckstein, A.M.; Haar Romeny, ter B.M.; Bronstein, A.M.; Bronstein, M.M.

    2012-01-01

    Multiplicative calculus provides a natural framework in problems involving positive images and positivity preserving operators. In increasingly important, complex imaging frameworks, such as diffusion tensor imaging, it complements standard calculus in a nontrivial way. The purpose of this article

  5. Biochemical characterization of the maltokinase from Mycobacterium bovis BCG

    Directory of Open Access Journals (Sweden)

    Lamosa Pedro

    2010-05-01

    Full Text Available Abstract Background Maltose-1-phosphate was detected in Mycobacterium bovis BCG extracts in the 1960's but a maltose-1-phosphate synthetase (maltokinase, Mak was only much later purified from Actinoplanes missouriensis, allowing the identification of the mak gene. Recently, this metabolite was proposed to be the intermediate in a pathway linking trehalose with the synthesis of glycogen in M. smegmatis. Although the M. tuberculosis H37Rv mak gene (Rv0127 was considered essential for growth, no mycobacterial Mak has, to date, been characterized. Results The sequence of the Mak from M. bovis BCG was identical to that from M. tuberculosis strains (99-100% amino acid identity. The enzyme was dependent on maltose and ATP, although GTP and UTP could be used to produce maltose-1-phosphate, which we identified by TLC and characterized by NMR. The Km for maltose was 2.52 ± 0.40 mM and 0.74 ± 0.12 mM for ATP; the Vmax was 21.05 ± 0.89 μmol/min.mg-1. Divalent cations were required for activity and Mg2+ was the best activator. The enzyme was a monomer in solution, had maximal activity at 60°C, between pH 7 and 9 (at 37°C and was unstable on ice and upon freeze/thawing. The addition of 50 mM NaCl markedly enhanced Mak stability. Conclusions The unknown role of maltokinases in mycobacterial metabolism and the lack of biochemical data led us to express the mak gene from M. bovis BCG for biochemical characterization. This is the first mycobacterial Mak to be characterized and its properties represent essential knowledge towards deeper understanding of mycobacterial physiology. Since Mak may be a potential drug target in M. tuberculosis, its high-level production and purification in bioactive form provide important tools for further functional and structural studies.

  6. Oral vaccination of guinea pigs with a Mycobacterium bovis bacillus Calmette-Guerin vaccine in a lipid matrix protects against aerosol infection with virulent M. bovis.

    Science.gov (United States)

    Clark, Simon; Cross, Martin L; Nadian, Allan; Vipond, Julia; Court, Pinar; Williams, Ann; Hewinson, R Glyn; Aldwell, Frank E; Chambers, Mark A

    2008-08-01

    Increased incidence of bovine tuberculosis (TB) in the United Kingdom caused by infection with Mycobacterium bovis is a cause of considerable economic loss to farmers and the government. The Eurasian badger (Meles meles) represents a wildlife source of recurrent M. bovis infections of cattle in the United Kingdom, and its vaccination against TB with M. bovis bacillus Calmette-Guérin (BCG) is an attractive disease control option. Delivery of BCG in oral bait holds the best prospect for vaccinating badgers over a wide geographical area. Using a guinea pig pulmonary challenge model, we evaluated the protective efficacy of candidate badger oral vaccines, based on broth-grown or ball-milled BCG, delivered either as aqueous suspensions or formulated in two lipids with differing fatty acid profiles (one being animal derived and the other being vegetable derived). Protection was determined in terms of increasing body weight after aerosol challenge with virulent M. bovis, reduced dissemination of M. bovis to the spleen, and, in the case of one oral formulation, restricted growth of M. bovis in the lungs. Only oral BCG formulated in lipid gave significant protection. These data point to the potential of the BCG-lipid formulation for further development as a tool for controlling tuberculosis in badgers.

  7. Series expansion in fractional calculus and fractional differential equations

    OpenAIRE

    Li, Ming-Fan; Ren, Ji-Rong; Zhu, Tao

    2009-01-01

    Fractional calculus is the calculus of differentiation and integration of non-integer orders. In a recently paper (Annals of Physics 323 (2008) 2756-2778), the Fundamental Theorem of Fractional Calculus is highlighted. Based on this theorem, in this paper we introduce fractional series expansion method to fractional calculus. We define a kind of fractional Taylor series of an infinitely fractionally-differentiable function. Further, based on our definition we generalize hypergeometric functio...

  8. Fuzzy relational calculus theory, applications and software

    CERN Document Server

    Peeva, Ketty

    2004-01-01

    This book examines fuzzy relational calculus theory with applications in various engineering subjects. The scope of the text covers unified and exact methods with algorithms for direct and inverse problem resolution in fuzzy relational calculus. Extensive engineering applications of fuzzy relation compositions and fuzzy linear systems (linear, relational and intuitionistic) are discussed. Some examples of such applications include solutions of equivalence, reduction and minimization problems in fuzzy machines, pattern recognition in fuzzy languages, optimization and inference engines in textile and chemical engineering, etc. A comprehensive overview of the authors' original work in fuzzy relational calculus is also provided in each chapter. The attached CD-Rom contains a toolbox with many functions for fuzzy calculations, together with an original algorithm for inverse problem resolution in MATLAB. This book is also suitable for use as a textbook in related courses at advanced undergraduate and graduate level...

  9. Calculus of tensors and differential forms

    CERN Document Server

    Sinha, Rajnikant

    2014-01-01

    Calculus of tensors and differential forms is an introductory-level textbook. Through this book, students will familiarize themselves with tools they need in order to use for further study on general relativity and research, such as affine tensors, tensor calculus on manifolds, relative tensors, Lie derivatives, wedge products, differential forms, and Stokes' theorem. The treatment is concrete and in detail, so that abstract concepts do not deter even physics and engineering students. This self contained book requires undergraduate-level calculus of several variables and linear algebra as prerequisite. Fubini's theorem in real analysis, to be used in Stokes' theorem, has been proved earlier than Stokes' theorem so that students don't have to search elsewhere.

  10. Fractional vector calculus and fractional Maxwell's equations

    International Nuclear Information System (INIS)

    Tarasov, Vasily E.

    2008-01-01

    The theory of derivatives and integrals of non-integer order goes back to Leibniz, Liouville, Grunwald, Letnikov and Riemann. The history of fractional vector calculus (FVC) has only 10 years. The main approaches to formulate a FVC, which are used in the physics during the past few years, will be briefly described in this paper. We solve some problems of consistent formulations of FVC by using a fractional generalization of the Fundamental Theorem of Calculus. We define the differential and integral vector operations. The fractional Green's, Stokes' and Gauss's theorems are formulated. The proofs of these theorems are realized for simplest regions. A fractional generalization of exterior differential calculus of differential forms is discussed. Fractional nonlocal Maxwell's equations and the corresponding fractional wave equations are considered

  11. A MATLAB companion for multivariable calculus

    CERN Document Server

    Cooper, Jeffery

    2001-01-01

    Offering a concise collection of MatLab programs and exercises to accompany a third semester course in multivariable calculus, A MatLab Companion for Multivariable Calculus introduces simple numerical procedures such as numerical differentiation, numerical integration and Newton''s method in several variables, thereby allowing students to tackle realistic problems. The many examples show students how to use MatLab effectively and easily in many contexts. Numerous exercises in mathematics and applications areas are presented, graded from routine to more demanding projects requiring some programming. Matlab M-files are provided on the Harcourt/Academic Press web site at http://www.harcourt-ap.com/matlab.html.* Computer-oriented material that complements the essential topics in multivariable calculus* Main ideas presented with examples of computations and graphics displays using MATLAB * Numerous examples of short code in the text, which can be modified for use with the exercises* MATLAB files are used to implem...

  12. Quantum geometry in dynamical Regge calculus

    International Nuclear Information System (INIS)

    Hagura, Hiroyuki

    2002-01-01

    We study geometric properties of dynamical Regge calculus which is a hybridization of dynamical triangulation and quantum Regge calculus. Lattice diffeomorphisms are generated by certain elementary moves on a simplicial lattice in the hybrid model. At the semiclassical level, we discuss a possibility that the lattice diffeomorphisms give a simple explanation for the Bekenstein-Hawking entropy of a black hole. At the quantum level, numerical calculations of 3D pure gravity show that a fractal structure of the hybrid model is the same as that of dynamical triangulation in the strong-coupling phase. In the weak-coupling phase, on the other hand, space-time becomes a spiky configuration, which often occurs in quantum Regge calculus

  13. The giant calculus within the prostatic urethra.

    Science.gov (United States)

    Demir, Omer; Kefi, Aykut; Cahangirov, Asif; Cihan, Ahmet; Obuz, Funda; Esen, Adil Ahmet; Celebi, Ilhan

    2011-08-01

    The giant calculus within the prostatic urethra is a rare clinical entity in the young population. Most of the calculi within the urethra migrate from the urinary bladder and obliterate the urethra. These stones are often composed of calcium phosphate or calcium oxalate. The decision of treatment strategy is affected by the size, shape and position of the calculus and by the status of the urethra. If the stone is large and immovable, it may be extracted via the perineal or the suprapubic approach. In most cases, the giant calculi were extracted via the transvesical approach and external urethrotomy. Our case is the biggest prostatic calculus, known in the literature so far, which was treated endoscopically by the combination of laser and the pneumatic lithotriptor.

  14. White noise calculus and Fock space

    CERN Document Server

    Obata, Nobuaki

    1994-01-01

    White Noise Calculus is a distribution theory on Gaussian space, proposed by T. Hida in 1975. This approach enables us to use pointwise defined creation and annihilation operators as well as the well-established theory of nuclear space.This self-contained monograph presents, for the first time, a systematic introduction to operator theory on fock space by means of white noise calculus. The goal is a comprehensive account of general expansion theory of Fock space operators and its applications. In particular,first order differential operators, Laplacians, rotation group, Fourier transform and their interrelations are discussed in detail w.r.t. harmonic analysis on Gaussian space. The mathematical formalism used here is based on distribution theory and functional analysis , prior knowledge of white noise calculus is not required.

  15. TWO-PHASE EJECTOR of CARBON DIOXIDE HEAT PUMP CALCULUS

    Directory of Open Access Journals (Sweden)

    Sit B.M.

    2010-12-01

    Full Text Available It is presented the calculus of the two-phase ejector for carbon dioxide heat pump. The method of calculus is based on the method elaborated by S.M. Kandil, W.E. Lear, S.A. Sherif, and is modified taking into account entrainment ratio as the input for the calculus.

  16. Science 101: How Do We Use Calculus in Science?

    Science.gov (United States)

    Robertson, Bill

    2014-01-01

    How is calculus used in science? That might seem like an odd question to answer in a magazine intended primarily for elementary school teachers. After all, how much calculus gets used in elementary science? Here the author guesses that quite a few readers of this column do not know a whole lot about calculus and have not taken a course in…

  17. A Transition Course from Advanced Placement to College Calculus

    Science.gov (United States)

    Lucas, Timothy A.; Spivey, Joseph

    2011-01-01

    In the Spring of 2007, a group of highly motivated mathematics graduate students conducted a review of Duke's Calculus curriculum. They focused on two main problems. The first problem is the result of a very positive trend: a growing number of students are earning AP credit for Calculus I in high school. However, this results in Calculus II…

  18. Improving Calculus II and III through the Redistribution of Topics

    Science.gov (United States)

    George, C. Yousuf; Koetz, Matt; Lewis, Heather A.

    2016-01-01

    Three years ago our mathematics department rearranged the topics in second and third semester calculus, moving multivariable calculus to the second semester and series to the third semester. This paper describes the new arrangement of topics, and how it could be adapted to calculus curricula at different schools. It also explains the benefits we…

  19. Giant Calculus In The Mouth Of Partially Edentulous Woman, (Case ...

    African Journals Online (AJOL)

    Objective: This case report is to create awareness of the presence of giant calculus in the mouth, the possible causes and its prevention. Report: This describes the oral condition of a partially edentulous woman with a giant calculus in the mouth. It highlights the effect of such an enormous calculus in the oral cavity.

  20. Computer Managed Instruction Homework Modules for Calculus I.

    Science.gov (United States)

    Goodman-Petrushka, Sharon; Roitberg, Yael

    This booklet contains 11 modules (290 multiple-choice items) designed for use in the first course of a three-course calculus sequence using the textbook "Calculus with Analytic Geometry" (Dennis G. Zill). In each module, relevant sections of the textbook are identified for users. It can, however, be used in conjunction with any calculus textbook.…

  1. ASSESSING STUDENTS' UNDERSTANDING OF PRE-CALCULUS CONCEPTS

    OpenAIRE

    Dr. Jyoti Sharma

    2017-01-01

    Calculus is one of the most momentous achievements of the human intellect (Boyer, 1949). It has given a new direction to the work of mathematicians and scientists. Calculus has exponentially expanded the scope and use of mathematics in other fields. Learning calculus is important to pursue career in applied mathematics.

  2. Proteomic profile of culture filtrate from the Brazilian vaccine strain Mycobacterium bovis BCG Moreau compared to M. bovis BCG Pasteur

    Directory of Open Access Journals (Sweden)

    Degrave Wim M

    2011-04-01

    Full Text Available Abstract Background Bacille Calmette-Guerin (BCG is currently the only available vaccine against tuberculosis (TB and comprises a heterogeneous family of sub-strains with genotypic and phenotypic differences. The World Health Organization (WHO affirms that the characterization of BCG sub-strains, both on genomic and proteomic levels, is crucial for a better comprehension of the vaccine. In addition, these studies can contribute in the development of a more efficient vaccine against TB. Here, we combine two-dimensional electrophoresis (2DE and mass spectrometry to analyse the proteomic profile of culture filtrate proteins (CFPs from M. bovis BCG Moreau, the Brazilian vaccine strain, comparing it to that of BCG Pasteur. CFPs are considered of great importance given their dominant immunogenicity and role in pathogenesis, being available for interaction with host cells since early infection. Results The 2DE proteomic map of M. bovis BCG Moreau CFPs in the pH range 3 - 8 allowed the identification of 158 spots corresponding to 101 different proteins, identified by MS/MS. Comparison to BCG Pasteur highlights the great similarity between these BCG strains. However, quantitative analysis shows a higher expression of immunogenic proteins such as Rv1860 (BCG1896, Apa, Rv1926c (BCG1965c, Mpb63 and Rv1886c (BCG1923c, Ag85B in BCG Moreau when compared to BCG Pasteur, while some heat shock proteins, such as Rv0440 (BCG0479, GroEL2 and Rv0350 (BCG0389, DnaK, show the opposite pattern. Conclusions Here we report the detailed 2DE profile of CFPs from M. bovis BCG Moreau and its comparison to BCG Pasteur, identifying differences that may provide relevant information on vaccine efficacy. These findings contribute to the detailed characterization of the Brazilian vaccine strain against TB, revealing aspects that may lead to a better understanding of the factors leading to BCG's variable protective efficacy against TB.

  3. Projects for calculus the language of change

    CERN Document Server

    Stroyan, Keith D

    1999-01-01

    Projects for Calculus is designed to add depth and meaning to any calculus course. The fifty-two projects presented in this text offer the opportunity to expand the use and understanding of mathematics. The wide range of topics will appeal to both instructors and students. Shorter, less demanding projects can be managed by the independent learner, while more involved, in-depth projects may be used for group learning. Each task draws on special mathematical topics and applications from subjects including medicine, engineering, economics, ecology, physics, and biology.Subjects including:* Medicine* Engineering* Economics* Ecology* Physics* Biology

  4. Multivariable dynamic calculus on time scales

    CERN Document Server

    Bohner, Martin

    2016-01-01

    This book offers the reader an overview of recent developments of multivariable dynamic calculus on time scales, taking readers beyond the traditional calculus texts. Covering topics from parameter-dependent integrals to partial differentiation on time scales, the book’s nine pedagogically oriented chapters provide a pathway to this active area of research that will appeal to students and researchers in mathematics and the physical sciences. The authors present a clear and well-organized treatment of the concept behind the mathematics and solution techniques, including many practical examples and exercises.

  5. Dynamical Regge calculus as lattice gravity

    International Nuclear Information System (INIS)

    Hagura, Hiroyuki

    2001-01-01

    We propose a hybrid approach to lattice quantum gravity by combining simultaneously the dynamical triangulation with the Regge calculus, called the dynamical Regge calculus (DRC). In this approach lattice diffeomorphism is realized as an exact symmetry by some hybrid (k, l) moves on the simplicial lattice. Numerical study of 3D pure gravity shows that an entropy of the DRC is not exponetially bounded if we adopt the uniform measure Π i dl i . On the other hand, using the scale-invariant measure Π i dl i /l i , we can calculate observables and observe a large hysteresis between two phases that indicates the first-order nature of the phase transition

  6. Variational calculus with constraints on general algebroids

    Energy Technology Data Exchange (ETDEWEB)

    Grabowska, Katarzyna [Physics Department, Division of Mathematical Methods in Physics, University of Warsaw, Hoza 69, 00-681 Warszawa (Poland); Grabowski, Janusz [Institute of Mathematics, Polish Academy of Sciences, Sniadeckich 8, PO Box 21, 00-956 Warszawa (Poland)], E-mail: konieczn@fuw.edu.pl, E-mail: jagrab@impan.gov.pl

    2008-05-02

    Variational calculus on a vector bundle E equipped with a structure of a general algebroid is developed, together with the corresponding analogs of Euler-Lagrange equations. Constrained systems are introduced in the variational and geometrical settings. The constrained Euler-Lagrange equations are derived for analogs of holonomic, vakonomic and nonholonomic constraints. This general model covers the majority of first-order Lagrangian systems which are present in the literature and reduces to the standard variational calculus and the Euler-Lagrange equations in classical mechanics for E = TM.

  7. Null-strut calculus. I. Kinematics

    International Nuclear Information System (INIS)

    Kheyfets, A.; LaFave, N.J.; Miller, W.A.

    1990-01-01

    This paper describes the kinematics of null-strut calculus---a 3+1 Regge calculus approach to general relativity. We show how to model the geometry of spacetime with simplicial spacelike three-geometries (TET's) linked to ''earlier'' and ''later'' momentumlike lattice surfaces (TET * ) entirely by light rays or ''null struts.'' These three-layered lattice spacetime geometries are defined and analyzed using combinatorial formulas for the structure of polytopes. The following paper in this series describes how these three-layered spacetime lattices are used to model spacetimes in full conformity with Einstein's theory of gravity

  8. Hybrid Logical Analyses of the Ambient Calculus

    DEFF Research Database (Denmark)

    Bolander, Thomas; Hansen, René Rydhof

    2007-01-01

    In this paper, hybrid logic is used to formulate a rational reconstruction of a previously published control flow analysis for the mobile ambients calculus and we further show how a more precise flow-sensitive analysis, that takes the ordering of action sequences into account, can be formulated...... in a natural way. We show that hybrid logic is very well suited to express the semantic structure of the ambient calculus and how features of hybrid logic can be exploited to reduce the "administrative overhead" of the analysis specification and thus simplify it. Finally, we use HyLoTab, a fully automated...

  9. Probabilistic Analysis of the Quality Calculus

    DEFF Research Database (Denmark)

    Nielson, Hanne Riis; Nielson, Flemming

    2013-01-01

    We consider a fragment of the Quality Calculus, previously introduced for defensive programming of software components such that it becomes natural to plan for default behaviour in case the ideal behaviour fails due to unreliable communication. This paper develops a probabilistically based trust...... analysis supporting the Quality Calculus. It uses information about the probabilities that expected input will be absent in order to determine the trustworthiness of the data used for controlling the distributed system; the main challenge is to take accord of the stochastic dependency between some...

  10. Modular invariance and covariant loop calculus

    International Nuclear Information System (INIS)

    Petersen, J.L.; Roland, K.O.; Sidenius, J.R.

    1988-01-01

    The covariant loop calculus provides and efficient technique for computing explicit expressions for the density on moduli space corresponding to arbitrary (bosonic string) loop diagrams. Since modular invariance is not manifest, however, we carry out a detailed comparison with known explicit 2- and 3- loop results derived using analytic geometry (1 loop is known to be ok). We establish identity to 'high' order in some moduli and exactly in others. Agreement is found as a result of various non-trivial cancellations, in part related to number theory. We feel our results provide very strong support for the correctness of the covariant loop calculus approach. (orig.)

  11. Variational calculus with constraints on general algebroids

    International Nuclear Information System (INIS)

    Grabowska, Katarzyna; Grabowski, Janusz

    2008-01-01

    Variational calculus on a vector bundle E equipped with a structure of a general algebroid is developed, together with the corresponding analogs of Euler-Lagrange equations. Constrained systems are introduced in the variational and geometrical settings. The constrained Euler-Lagrange equations are derived for analogs of holonomic, vakonomic and nonholonomic constraints. This general model covers the majority of first-order Lagrangian systems which are present in the literature and reduces to the standard variational calculus and the Euler-Lagrange equations in classical mechanics for E = TM

  12. Modular invariance and covariant loop calculus

    International Nuclear Information System (INIS)

    Petersen, J.L.; Roland, K.O.; Sidenius, J.R.

    1988-01-01

    The covariant loop calculus provides an efficient technique for computing explicit expressions for the density on moduli space corresponding to arbitrary (bosonic string) loop diagrams. Since modular invariance is not manifest, however, we carry out a detailed comparison with known explicit two- and three-loop results derived using analytic geometry (one loop is known to be okay). We establish identity to 'high' order in some moduli and exactly in others. Agreement is found as a result of various nontrivial cancellations, in part related to number theory. We feel our results provide very strong support for the correctness of the covariant loop calculus approach. (orig.)

  13. A sequent calculus for signed interval logic

    DEFF Research Database (Denmark)

    Rasmussen, Thomas Marthedal

    2001-01-01

    We propose and discuss a complete sequent calculus formulation for Signed Interval Logic (SIL) with the chief purpose of improving proof support for SIL in practice. The main theoretical result is a simple characterization of the limit between decidability and undecidability of quantifier-free SIL....... We present a mechanization of SIL in the generic proof assistant Isabelle and consider techniques for automated reasoning. Many of the results and ideas of this report are also applicable to traditional (non-signed) interval logic and, hence, to Duration Calculus....

  14. Cytochemical and biological properties of Mycobacterium bovis BCG.

    Science.gov (United States)

    Slosárek, M

    1977-01-01

    It was the aim of the present communication to find a simple test for a reliable discrimination of Mycobacterium bovis BCG from Mycobacterium tuberculosis. A total of 26 BCG strains, out of them 10 Czechoslovak strains (2 lyophilized cultures of BCG of different batch, 6 strains isolated from abscesses of children after BCG-vaccination and 2 strains from fatal cases after BCG-vaccination) and 16 strains obtained from foreign laboratories, were used. Of the tested characteristics a combination of 3 tests, sensitivity to 1 microgram of 2-thiophene carbonylhydrazide (TCH), activity of 3 acylamidases (urease, nicotinamidase and pyrazinamidase) and a quantitative nitrate test, was found to be most advantageous. The Czechoslovak strains of Mycobacterium bovis BCG were fully sensitive to TCH, of the 3 acylamidases mentioned above only urease was positive and nitrate was reduced only little or not at all. On the other hand, strains of Mycobacterium tuberculosis were always resistant to TCH, had positive urease, nicotinamidase and pyrazinamidase and reduced nitrate very intensively.

  15. [Mycobacterial bovis BCG cutaneous infections following mesotherapy: 2 cases].

    Science.gov (United States)

    Marco-Bonnet, J; Beylot-Barry, M; Texier-Maugein, J; Barucq, J P; Supply, P; Doutre, M S; Beylot, C

    2002-05-01

    Infectious complications following mesotherapy are usually due to ordinary bacteria or atypical mycobacteria. We report two new cases of mycobacterial bovis BCG infections following mesotherapy. To our knowledge only one case has already been reported. A 52 year-old woman developed vaccinal MERIEUX BCG cutaneous abscesses following mesotherapy. Identification was made by a novel class of repeated sequences: Mycobacterial interspersed repetitive units. Despite prolonged anti-tuberculous therapy, complete remission was not obtained and surgical excision was performed. The second case was a 49 year-old man who developed a mycobacterial bovis BCG cutaneous abscess (Connaught) after mesotherapy, the regression of which was obtained with anti-tuberculous therapy. The severity of these two mycobacterial infections following mesotherapy illustrate the potential risks of mesotherapy. Identification is possible by molecular biology techniques (PCR and sequencing). The origin of this infection is unclear and therapeutic decision is difficult. Some authors recommend anti-tuberculous therapy but surgical excision may be necessary as in our cases.

  16. Study on radiosterilization of crude drug pill involving bezoar bovis

    International Nuclear Information System (INIS)

    Kimura, Syojiro; Sasaki, Masahiro; Kondo, Yuichi; Jo, Hisanobu; Kanbashi, Toshitaka.

    1981-01-01

    Radiolysis of bilirubin and cholic acids (cholic acid, desoxycholic acid and lithocholic acid) in hydrous pellet have been investigated with following parameters, which were hydrous content, radiation dose and the dose rate, to discuss the application of gamma -irradiation for sterilization of crude drug pill involving bezoar bovis. At 774 C/kg(3.0MR) irradiation for 5% and 10% hydrous contents pellets, the radiolysis percent of those components were less than 5%. However, the higher hydrous pellet, the radiolysis percents of those are more increase. At the same irradiated condition for 20% hydrous contents pellets, the radiolysis percents of those were 15--22%. The hydrous percent of commercial crude drug pill involving bezoar bovis are about 9%, so that the radiolysis of those components will be less than 5% on the sterilization. The radiolysis percent of bilirubin are constant to variation of radiation dose rate between 51.6--722.5C/kg.hr(0.2--2.8MR/hr). But, the values of cholic acids don't definite such as that of bilirubin, because of larger analitycal error. (author)

  17. Genotyping did not evidence any contribution of Mycobacterium bovis to human tuberculosis in Brazil.

    Science.gov (United States)

    Rocha, Adalgiza; Elias, Atina R; Sobral, Luciana F; Soares, Diego F; Santos, Alexandre C; Marsico, Ana-Grazia; Hacker, Mariana A; Caldas, Paulo C; Parente, Luiz C; Silva, Marcio R; Fonseca, Leila; Suffys, Philip; Boéchat, Neio

    2011-01-01

    The contribution of Mycobacterium bovis to the global burden of tuberculosis (TB) in man is likely to be underestimated due to its dysgonic growth characteristics and because of the absence of pyruvate in most used media is disadvantageous for its primary isolation. In Brazil Mycobacterium culture, identification and susceptibility tests are performed only in TB reference centers, usually for selected cases. Moreover, solid, egg-based, glycerol-containing (without pyruvate supplementation) Löwenstein-Jensen (L-J) or Ogawa media are routinely used, unfavouring M. bovis isolation. To determine the importance of M. bovis as a public health threat in Brazil we investigated 3046 suspected TB patients inoculating their clinical samples onto routine L-J and L-J pyruvate enriched media. A total of 1796 specimens were culture positive for Mycobacterium spp. and 702 TB cases were confirmed. Surprisingly we did not detect one single case of M. bovis in the resulting collection of 1674 isolates recovered from M. bovis favourable medium analyzed by conventional and molecular speciation methods. Also, bacillary DNA present on 454 sputum smears from 223 TB patients were OxyR genotyped and none was recognized as M. bovis. Our data indicate that M. bovis importance on the burden of human TB in Brazil is marginal. Copyright © 2010 Elsevier Ltd. All rights reserved.

  18. A specific DNA probe which identifies Babesia bovis in whole blood.

    Science.gov (United States)

    Petchpoo, W; Tan-ariya, P; Boonsaeng, V; Brockelman, C R; Wilairat, P; Panyim, S

    1992-05-01

    A genomic library of Babesia bovis DNA from the Mexican strain M was constructed in plasmid pUN121 and cloned in Escherichia coli. Several recombinants which hybridized strongly to radioactively labeled B. bovis genomic DNA in an in situ screening were selected and further analyzed for those which specifically hybridized to B. bovis DNA. It was found that pMU-B1 had the highest sensitivity, detecting 25 pg of purified B. bovis DNA, and 300 parasites in 10 microliters of whole infected blood, or 0.00025% parasitemia. pMU-B1 contained a 6.0 kb B. bovis DNA insert which did not cross-hybridize to Babesia bigemina, Trypanosoma evansi, Plasmodium falciparum, Anaplasma marginale, Boophilus microplus and cow DNA. In the Southern blot analysis of genomic DNA, pMU-B1 could differentiate between two B. bovis geographic isolates, Mexican strain M and Thai isolate TS4. Thus, the pMU-B1 probe will be useful in the diagnosis of Babesia infection in cattle and ticks, and in the differentiation of B. bovis strains.

  19. Isolation and molecular characterization of Mycobacterium bovis causing pulmonary tuberculosis and epistaxis in a Thoroughbred horse.

    Science.gov (United States)

    Hlokwe, Tiny Motlatso; Sutton, David; Page, Patrick; Michel, Anita Luise

    2016-09-02

    Tuberculosis caused by Mycobacterium bovis (M. bovis) is very uncommon in horses worldwide. In the current study, an eight-year-old male Thoroughbred in good body condition was admitted to the Equine Clinic at the Onderstepoort Veterinary Academic Hospital in 2005 due to bilateral epistaxis accompanied by coughing. Routine examinations were conducted to determine the cause of the condition. Endoscopic examination revealed the major source of the epistaxis as the trachea, whereas thoracic radiography indicated the presence of a primary pulmonary mass. M. bovis was isolated from a broncho-alveolar lavage (BAL) sample collected. The pulmonary mass reduced in size three months later following an oral administration of enrofloxacin (7.5 mg/kg PO SID). Genetic fingerprinting by spoligotyping identified the M. bovis isolate as spoligotype SB0868 strain. This M. bovis strain type was never described previously in South Africa (SA). This is the first case of M. bovis infection in a horse in SA which has been fully documented including clinical findings, isolation and genetic characterisation of the causative pathogen. This report indicates that horses may contract and harbour M. bovis despite their lower susceptibility compared to other domestic animals. It also suggests that the infection may be more easily contained and eliminated from the host.

  20. Analysis of Streptococcus bovis infections at a monographic oncological centre

    Directory of Open Access Journals (Sweden)

    Lozano TG

    2014-02-01

    Full Text Available The Streptococcus bovis is a Gram-positive, facultative anaerobic, catalase and oxidase negative coccus belonging to the genus Streptococcus. It is part of Streptoccus bovis/ equinus complex and it express the Lancefield antigen D on the surface.This complex has been characterized by molecular biology techniques and specifically by 16S rRNA and sodA gene. Phylogenetic trees based on these techniques are complex and therefore the routine work in laboratories, biochemical techniques are used to identify subspecies if it is necessary.The complex is divided into two subtypes based on biochemical properties: positive mannitol fermentation (biotype I including S. gallolyticus (S. gallolyticus subsp. gallolyticus and S. gallolyticus subsp. macedonicus, mannitol negative and ß-glucuronidase negative (biotype II/ 1, which includes more species (S. infantarius subsp. coli and S. lutetiensis and mannitol negative and ß-glucuronidase positive (biotype II/ 2, with a single species called S. gallolyticus subsp. pasteurianus.Owing to the relationship between colon cancer tumour and Streptococcus bovis, we intend to analyse all isolates in our hospital between the periods of 2010 until March 2013 and analyse tumor epidemiology at our center, in patients infected with this pathogen.Despite the different types of samples and out of the possibility of identification of subspecies, were isolated 14 S. bovis of 14 different patients. The isolates patients were (at the beginning: 4 blood (blood culture, 5 urine, 4 multiple exudates and 1 bronchoalveolar lavage. The proportion of men and women was 8/6. The mean age was 67 years (56±91. Malignant tumor distribution was: 6 prostate cancer, 1 breast cancer, 1 biliary tract, 1 skin, 1, stomach, 1 uterus, 1 vulvar, 1 pyriform sinus and other reproductive organs without specify.The study of antimicrobial in vitro susceptibility was performed by microdilution (MicroScan® WalkAway, Siemens, Sacramento, CA, USA and the

  1. Surveillance of a Ventilated Rack System for Corynebacterium bovis by Sampling Exhaust-Air Manifolds.

    Science.gov (United States)

    Manuel, Christopher A; Pugazhenthi, Umarani; Leszczynski, Jori K

    2016-01-01

    Corynebacterium bovis causes an opportunistic infection of nude (Foxn1, nu/nu) mice, leading to nude mouse hyperkeratotic dermatitis (scaly skin disease). Enzootic in many nude mouse colonies, C. bovis spreads rapidly to naive nude mice, despite modern husbandry practices, and is very difficult to eradicate. To facilitate rapid detection in support of eradication efforts, we investigated a surveillance method based on quantitative real-time PCR (qPCR) evaluation of swabs collected from the horizontal exhaust manifold (HEM) of an IVC rack system. We first evaluated the efficacy of rack sanitation methods for removing C. bovis DNA from the HEM of racks housing endemic colonies of infected nude mice. Pressurized water used to flush the racks' air exhaust system followed by a standard rack-washer cycle was ineffective in eliminating C. bovis DNA. Only after autoclaving did all sanitized racks test negative for C. bovis DNA. We then measured the effects of stage of infection (early or established), cage density, and cage location on the rack on time-to-detection at the HEM. Stage of infection significantly affected time-to-detection, independent of cage location. Early infections required 7.3 ± 1.2 d whereas established infections required 1 ± 0 d for detection of C. bovis at the HEM. Cage density influenced the quantity of C. bovis DNA detected but not time-to-detection. The location of the cage on the rack affected the time-to-detection only during early C. bovis infections. We suggest that qPCR swabs of HEM are useful during the routine surveillance of nude mouse colonies for C. bovis infection.

  2. Mycobacterium bovis in Burkina Faso: epidemiologic and genetic links between human and cattle isolates.

    Directory of Open Access Journals (Sweden)

    Adama Sanou

    2014-10-01

    Full Text Available In sub-Saharan Africa, bovine tuberculosis (bTB is a potential hazard for animals and humans health. The goal of this study was to improve our understanding of bTB epidemiology in Burkina Faso and especially Mycobacterium bovis transmission within and between the bovine and human populations.Twenty six M. bovis strains were isolated from 101 cattle carcasses with suspected bTB lesions during routine meat inspections at the Bobo Dioulasso and Ouagadougou slaughterhouses. In addition, 7 M. bovis strains were isolated from 576 patients with pulmonary tuberculosis. Spoligotyping, RDAf1 deletion and MIRU-VNTR typing were used for strains genotyping. The isolation of M. bovis strains was confirmed by spoligotyping and 12 spoligotype signatures were detected. Together, the spoligotyping and MIRU-VNTR data allowed grouping the 33 M. bovis isolates in seven clusters including isolates exclusively from cattle (5 or humans (1 or from both (1. Moreover, these data (genetic analyses and phenetic tree showed that the M. bovis isolates belonged to the African 1 (Af1 clonal complex (81.8% and the putative African 5 (Af5 clonal complex (18.2%, in agreement with the results of RDAf1 deletion typing.This is the first detailed molecular characterization of M. bovis strains from humans and cattle in Burkina Faso. The distribution of the two Af1 and putative Af5 clonal complexes is comparable to what has been reported in neighbouring countries. Furthermore, the strain genetic profiles suggest that M. bovis circulates across the borders and that the Burkina Faso strains originate from different countries, but have a country-specific evolution. The genetic characterization suggests that, currently, M. bovis transmission occurs mainly between cattle, occasionally between cattle and humans and potentially between humans. This study emphasizes the bTB risk in cattle but also in humans and the difficulty to set up proper disease control strategies in Burkina Faso.

  3. Mycobacterium bovis in Burkina Faso: epidemiologic and genetic links between human and cattle isolates.

    Science.gov (United States)

    Sanou, Adama; Tarnagda, Zekiba; Kanyala, Estelle; Zingué, Dezemon; Nouctara, Moumini; Ganamé, Zakaria; Combary, Adjima; Hien, Hervé; Dembele, Mathurin; Kabore, Antoinette; Meda, Nicolas; Van de Perre, Philippe; Neveu, Dorine; Bañuls, Anne Laure; Godreuil, Sylvain

    2014-10-01

    In sub-Saharan Africa, bovine tuberculosis (bTB) is a potential hazard for animals and humans health. The goal of this study was to improve our understanding of bTB epidemiology in Burkina Faso and especially Mycobacterium bovis transmission within and between the bovine and human populations. Twenty six M. bovis strains were isolated from 101 cattle carcasses with suspected bTB lesions during routine meat inspections at the Bobo Dioulasso and Ouagadougou slaughterhouses. In addition, 7 M. bovis strains were isolated from 576 patients with pulmonary tuberculosis. Spoligotyping, RDAf1 deletion and MIRU-VNTR typing were used for strains genotyping. The isolation of M. bovis strains was confirmed by spoligotyping and 12 spoligotype signatures were detected. Together, the spoligotyping and MIRU-VNTR data allowed grouping the 33 M. bovis isolates in seven clusters including isolates exclusively from cattle (5) or humans (1) or from both (1). Moreover, these data (genetic analyses and phenetic tree) showed that the M. bovis isolates belonged to the African 1 (Af1) clonal complex (81.8%) and the putative African 5 (Af5) clonal complex (18.2%), in agreement with the results of RDAf1 deletion typing. This is the first detailed molecular characterization of M. bovis strains from humans and cattle in Burkina Faso. The distribution of the two Af1 and putative Af5 clonal complexes is comparable to what has been reported in neighbouring countries. Furthermore, the strain genetic profiles suggest that M. bovis circulates across the borders and that the Burkina Faso strains originate from different countries, but have a country-specific evolution. The genetic characterization suggests that, currently, M. bovis transmission occurs mainly between cattle, occasionally between cattle and humans and potentially between humans. This study emphasizes the bTB risk in cattle but also in humans and the difficulty to set up proper disease control strategies in Burkina Faso.

  4. Detection, removal and prevention of calculus: Literature Review

    Directory of Open Access Journals (Sweden)

    Deepa G. Kamath

    2014-01-01

    Full Text Available Dental plaque is considered to be a major etiological factor in the development of periodontal disease. Accordingly, the elimination of supra- and sub-gingival plaque and calculus is the cornerstone of periodontal therapy. Dental calculus is mineralized plaque; because it is porous, it can absorb various toxic products that can damage the periodontal tissues. Hence, calculus should be accurately detected and thoroughly removed for adequate periodontal therapy. Many techniques have been used to identify and remove calculus deposits present on the root surface. The purpose of this review was to compile the various methods and their advantages for the detection and removal of calculus.

  5. Success in Introductory Calculus: The Role of High School and Pre-calculus Preparation

    OpenAIRE

    Ayebo, Abraham; Ukkelberg, Sarah; Assuah, Charles

    2017-01-01

    Calculus at the college level has significantpotential to serve as a pump for increasing the number of students majoring inSTEM fields. It is a foundation course for all STEM majors and, if mastered well,should provide students with a positive and successful first-year experienceand gateway into more advanced courses. Studies have shown that a high percentage of studentsfailing college calculus has caused a shortage of individuals entering fieldsthat are heavily dependent on mathematics. Many...

  6. Susceptibilities of Mycoplasma bovis, Mycoplasma dispar, and Ureaplasma diversum strains to antimicrobial agents in vitro.

    OpenAIRE

    ter Laak, E A; Noordergraaf, J H; Verschure, M H

    1993-01-01

    The purpose of this study was to determine the susceptibility of various strains of Mycoplasma bovis, Mycoplasma dispar, and Ureaplasma diversum, which are prevalent causes of pneumonia in calves, to 16 antimicrobial agents in vitro. The MICs of the antimicrobial agents were determined by a serial broth dilution method for 16 field strains and the type strain of M. bovis, for 19 field strains and the type strain of M. dispar, and for 17 field strains of U. diversum. Final MICs for M. bovis an...

  7. A Typed Functional Calculus With State

    NARCIS (Netherlands)

    Rensink, Arend; Müllhäuser, M.

    1997-01-01

    We extend the simple typed \\lambda-calculus with statements. A statement (which can also be thought of as a method or transition) is an abstraction similar to function abstraction: it can be instantiated by providing it with a source state, whereafter it yields a pair of values consisting of an

  8. Boolean integral calculus for digital systems

    Science.gov (United States)

    Tucker, J. H.; Tapia, M. A.; Bennett, A. W.

    1985-01-01

    The concept of Boolean integration is introduced and developed. When the changes in a desired function are specified in terms of changes in its arguments, then ways of 'integrating' (i.e., realizing) the function, if it exists, are presented. Boolean integral calculus has applications in design of logic circuits.

  9. Dogs Don't Need Calculus

    Science.gov (United States)

    Bolt, Mike

    2010-01-01

    Many optimization problems can be solved without resorting to calculus. This article develops a new variational method for optimization that relies on inequalities. The method is illustrated by four examples, the last of which provides a completely algebraic solution to the problem of minimizing the time it takes a dog to retrieve a thrown ball,…

  10. Spinor calculus on 5-dimensional spacetimes

    International Nuclear Information System (INIS)

    Gomez-Lobo, Alfonso Garcia-Parrado; Martin-Garcia, Jose M

    2010-01-01

    We explain how Penrose's spinor calculus of 4-dimensional Lorentzian geometry is implemented in a 5-dimensional Lorentzian manifold. A number of issues, such as the essential spin algebra, the spin covariant derivative and the algebro-differential properties of the curvature spinors are discussed.

  11. Bladder calculus presenting as excessive masturbation.

    Science.gov (United States)

    De Alwis, A C D; Senaratne, A M R D; De Silva, S M P D; Rodrigo, V S D

    2006-09-01

    Masturbation in childhood is a normal behaviour which most commonly begins at 2 months of age, and peaks at 4 years and in adolescence. However excessive masturbation causes anxiety in parents. We describe a boy with a bladder calculus presenting as excessive masturbation.

  12. Continuous fragment of the mu-calculus

    NARCIS (Netherlands)

    Fontaine, G.

    2008-01-01

    In this paper we investigate the Scott continuous fragment of the modal μ-calculus. We discuss its relation with constructivity, where we call a formula constructive if its least fixpoint is always reached in at most ω steps. Our main result is a syntactic characterization of this continuous

  13. Cartan calculus on quantum Lie algebras

    International Nuclear Information System (INIS)

    Schupp, P.; Watts, P.; Zumino, B.

    1993-01-01

    A generalization of the differential geometry of forms and vector fields to the case of quantum Lie algebras is given. In an abstract formulation that incorporates many existing examples of differential geometry on quantum spaces we combine an exterior derivative, inner derivations, Lie derivatives, forms and functions au into one big algebra, the ''Cartan Calculus.''

  14. The fundamental theorem of linearised Regge calculus

    International Nuclear Information System (INIS)

    Barrett, J.W.

    1987-01-01

    In linearised Regge calculus in a topologically trivial region, the space of linearised deviations of the edge lengths from a flat configuration, divided by the subspace of deformations due to translations of the vertices, is equivalent to the space of the linearised curvatures which satisfy the Bianchi identities. (orig.)

  15. A new approach to the Regge calculus

    International Nuclear Information System (INIS)

    Porter, J.

    1987-01-01

    In paper 1 an original '3 + 1' form of Regge calculus was developed. In the current paper the method is tested by application to spherically symmetric vacuum space-times. Three different time slicing conditions are used and, where appropriate, the results are compared with the analytic solution with encouraging results. (author)

  16. A new approach to the Regge calculus

    International Nuclear Information System (INIS)

    Porter, J.

    1987-01-01

    The paper develops a new approach to Regge calculus, a numerical technique used for the calculation of general relativistic spacetimes. The method is developed in an original '3 + 1' form in such a way that it can be applied to inhomogeneous spacetimes. (author)

  17. Note on 3-dimensional Regge calculus

    International Nuclear Information System (INIS)

    Soda, Jiro

    1991-01-01

    We shall study 3-dimensional Regge calculus with concentrating the role of the Bianchi identity. As a result, the number of the physical variables is determined to be 12g - 12(g > 1). The reason why Rocek and Williams derived the exact result of Deser, Jackiw and 'tHooft is clarified. (author)

  18. Enabling quaternion derivatives: the generalized HR calculus

    Science.gov (United States)

    Xu, Dongpo; Jahanchahi, Cyrus; Took, Clive C.; Mandic, Danilo P.

    2015-01-01

    Quaternion derivatives exist only for a very restricted class of analytic (regular) functions; however, in many applications, functions of interest are real-valued and hence not analytic, a typical case being the standard real mean square error objective function. The recent HR calculus is a step forward and provides a way to calculate derivatives and gradients of both analytic and non-analytic functions of quaternion variables; however, the HR calculus can become cumbersome in complex optimization problems due to the lack of rigorous product and chain rules, a consequence of the non-commutativity of quaternion algebra. To address this issue, we introduce the generalized HR (GHR) derivatives which employ quaternion rotations in a general orthogonal system and provide the left- and right-hand versions of the quaternion derivative of general functions. The GHR calculus also solves the long-standing problems of product and chain rules, mean-value theorem and Taylor's theorem in the quaternion field. At the core of the proposed GHR calculus is quaternion rotation, which makes it possible to extend the principle to other functional calculi in non-commutative settings. Examples in statistical learning theory and adaptive signal processing support the analysis. PMID:26361555

  19. Fractional vector calculus for fractional advection dispersion

    Science.gov (United States)

    Meerschaert, Mark M.; Mortensen, Jeff; Wheatcraft, Stephen W.

    2006-07-01

    We develop the basic tools of fractional vector calculus including a fractional derivative version of the gradient, divergence, and curl, and a fractional divergence theorem and Stokes theorem. These basic tools are then applied to provide a physical explanation for the fractional advection-dispersion equation for flow in heterogeneous porous media.

  20. On varitional iteration method for fractional calculus

    Directory of Open Access Journals (Sweden)

    Wu Hai-Gen

    2017-01-01

    Full Text Available Modification of the Das’ variational iteration method for fractional differential equations is discussed, and its main shortcoming involved in the solution process is pointed out and overcome by using fractional power series. The suggested computational procedure is simple and reliable for fractional calculus.

  1. A Note on Discrete Mathematics and Calculus.

    Science.gov (United States)

    O'Reilly, Thomas J.

    1987-01-01

    Much of the current literature on the topic of discrete mathematics and calculus during the first two years of an undergraduate mathematics curriculum is cited. A relationship between the recursive integration formulas and recursively defined polynomials is described. A Pascal program is included. (Author/RH)

  2. Supercalculators and University Entrance Calculus Examinations.

    Science.gov (United States)

    Hong, Ye Yoon; Thomas, Mike; Kiernan, Christine

    2000-01-01

    Investigates whether the use of computer algebra systems could provide a significant advantage to students taking standard university entrance calculus examinations. Indicates that supercalculators would probably provide a significant advantage, particularly for lower-achieving students. Demonstrates that it is possible to write questions in which…

  3. Using Discovery in the Calculus Class

    Science.gov (United States)

    Shilgalis, Thomas W.

    1975-01-01

    This article shows how two discoverable theorems from elementary calculus can be presented to students in a manner that assists them in making the generalizations themselves. The theorems are the mean value theorems for derivatives and for integrals. A conjecture is suggested by pictures and then refined. (Author/KM)

  4. Exploring Flipped Classroom Instruction in Calculus III

    Science.gov (United States)

    Wasserman, Nicholas H.; Quint, Christa; Norris, Scott A.; Carr, Thomas

    2017-01-01

    In an undergraduate Calculus III class, we explore the effect of "flipping" the instructional delivery of content on both student performance and student perceptions. Two instructors collaborated to determine daily lecture notes, assigned the same homework problems, and gave identical exams; however, compared to a more traditional…

  5. Teaching Calculus Students How to Study.

    Science.gov (United States)

    Boelkins, Matthew R.; Pfaff, Thomas J.

    1998-01-01

    Addresses the problem of poor study habits in calculus students and presents techniques to teach students how to study consistently and effectively. Concludes that many students greatly appreciate the added structure, work harder than in previous courses, and witness newfound success as a consequence. (Author/ASK)

  6. Some Factors Effected Student's Calculus Learning Outcome

    Science.gov (United States)

    Rajagukguk, Wamington

    2016-01-01

    The purpose of this study is to determine the factors effected calculus learning outcome of the student. This study was conducted with 176 respondents, which were selected randomly. The data were obtained by questionnaire, and then analyzed by using multiple regressions, and correlation, at level of a = 0.05. The findings showed there is the…

  7. Scale calculus and the Schroedinger equation

    International Nuclear Information System (INIS)

    Cresson, Jacky

    2003-01-01

    This paper is twofold. In a first part, we extend the classical differential calculus to continuous nondifferentiable functions by developing the notion of scale calculus. The scale calculus is based on a new approach of continuous nondifferentiable functions by constructing a one parameter family of differentiable functions f(t,ε) such that f(t,ε)→f(t) when ε goes to zero. This led to several new notions as representations: fractal functions and ε-differentiability. The basic objects of the scale calculus are left and right quantum operators and the scale operator which generalizes the classical derivative. We then discuss some algebraic properties of these operators. We define a natural bialgebra, called quantum bialgebra, associated with them. Finally, we discuss a convenient geometric object associated with our study. In a second part, we define a first quantization procedure of classical mechanics following the scale relativity theory developed by Nottale. We obtain a nonlinear Schroedinger equation via the classical Newton's equation of dynamics using the scale operator. Under special assumptions we recover the classical Schroedinger equation and we discuss the relevance of these assumptions

  8. Symbolic boundary calculus and feedback operators

    DEFF Research Database (Denmark)

    Pedersen, Michael

    1991-01-01

    The recent developments in microlocal analysis and pseudodifferential boundary calculus are well suited tools in the investigation of a large number of problems occurring in control theory for partial differential equations. We explain some of the basic ideas of a pseudodifferential model...

  9. Length expectation values in quantum Regge calculus

    International Nuclear Information System (INIS)

    Khatsymovsky, V.M.

    2004-01-01

    Regge calculus configuration superspace can be embedded into a more general superspace where the length of any edge is defined ambiguously depending on the 4-tetrahedron containing the edge. Moreover, the latter superspace can be extended further so that even edge lengths in each the 4-tetrahedron are not defined, only area tensors of the 2-faces in it are. We make use of our previous result concerning quantization of the area tensor Regge calculus which gives finite expectation values for areas. Also our result is used showing that quantum measure in the Regge calculus can be uniquely fixed once we know quantum measure on (the space of the functionals on) the superspace of the theory with ambiguously defined edge lengths. We find that in this framework quantization of the usual Regge calculus is defined up to a parameter. The theory may possess nonzero (of the order of Planck scale) or zero length expectation values depending on whether this parameter is larger or smaller than a certain value. Vanishing length expectation values means that the theory is becoming continuous, here dynamically in the originally discrete framework

  10. Are Homeschoolers Prepared for College Calculus?

    Science.gov (United States)

    Wilkens, Christian P.; Wade, Carol H.; Sonnert, Gerhard; Sadler, Philip M.

    2015-01-01

    Homeschooling in the United States has grown considerably over the past several decades. This article presents findings from the Factors Influencing College Success in Mathematics (FICSMath) survey, a national study of 10,492 students enrolled in tertiary calculus, including 190 students who reported homeschooling for a majority of their high…

  11. Discrete Calculus as a Bridge between Scales

    Science.gov (United States)

    Degiuli, Eric; McElwaine, Jim

    2012-02-01

    Understanding how continuum descriptions of disordered media emerge from the microscopic scale is a fundamental challenge in condensed matter physics. In many systems, it is necessary to coarse-grain balance equations at the microscopic scale to obtain macroscopic equations. We report development of an exact, discrete calculus, which allows identification of discrete microscopic equations with their continuum equivalent [1]. This allows the application of powerful techniques of calculus, such as the Helmholtz decomposition, the Divergence Theorem, and Stokes' Theorem. We illustrate our results with granular materials. In particular, we show how Newton's laws for a single grain reproduce their continuum equivalent in the calculus. This allows introduction of a discrete Airy stress function, exactly as in the continuum. As an application of the formalism, we show how these results give the natural mean-field variation of discrete quantities, in agreement with numerical simulations. The discrete calculus thus acts as a bridge between discrete microscale quantities and continuous macroscale quantities. [4pt] [1] E. DeGiuli & J. McElwaine, PRE 2011. doi: 10.1103/PhysRevE.84.041310

  12. Students' Difficulties with Vector Calculus in Electrodynamics

    Science.gov (United States)

    Bollen, Laurens; van Kampen, Paul; De Cock, Mieke

    2015-01-01

    Understanding Maxwell's equations in differential form is of great importance when studying the electrodynamic phenomena discussed in advanced electromagnetism courses. It is therefore necessary that students master the use of vector calculus in physical situations. In this light we investigated the difficulties second year students at KU Leuven…

  13. Advanced calculus of a single variable

    CERN Document Server

    Geveci, Tunc

    2016-01-01

    This advanced undergraduate textbook is based on a one-semester course on single variable calculus that the author has been teaching at San Diego State University for many years. The aim of this classroom-tested book is to deliver a rigorous discussion of the concepts and theorems that are dealt with informally in the first two semesters of a beginning calculus course. As such, students are expected to gain a deeper understanding of the fundamental concepts of calculus, such as limits (with an emphasis on ε-δ definitions), continuity (including an appreciation of the difference between mere pointwise and uniform continuity), the derivative (with rigorous proofs of various versions of L’Hôpital’s rule) and the Riemann integral (discussing improper integrals in-depth, including the comparison and Dirichlet tests). Success in this course is expected to prepare students for more advanced courses in real and complex analysis and this book will help to accomplish this. The first semester of advanced calculus...

  14. Online Calculus: The Course and Survey Results.

    Science.gov (United States)

    Allen, G. Donald

    2001-01-01

    Describes the development and implementation of a Web-based calculus course at Texas A & M University. Discusses the course design, layout of content and the contrast with textbook structure, results of course surveys that included student reactions, and how students learn form Web-based materials. (Author/LRW)

  15. Maple Graphing Tools for Calculus III

    Science.gov (United States)

    Cook, Darwyn

    2006-01-01

    For those instructors lacking artistic skills, teaching 3-dimensional calculus can be a challenge. Although some instructors spend a great deal of time working on their illustrations, trying to get them just right, students nevertheless often have a difficult time understanding some of them. To address this problem, the author has written a series…

  16. Elementary Business Calculus with Computer Algebra.

    Science.gov (United States)

    Judson, Phoebe T.

    1990-01-01

    Described are various ways that a computer algebra system (MAPLE) was used to facilitate the resequencing of skills and applications within an elementary college-level business calculus course. Experimental results confirmed earlier findings that skills acquisition is not a prerequisite to conceptual understanding or problem-solving ability. (JJK)

  17. Is Calculus a Failure in Cryptography?

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 21; Issue 3. Is Calculus a Failure in Cryptography? P Vanchinathan. General Article Volume 21 Issue 3 March 2016 pp 239-245. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/021/03/0239-0245. Keywords.

  18. Full Lambek Calculus with Contraction is Undecidable

    Czech Academy of Sciences Publication Activity Database

    Chvalovský, Karel; Horčík, Rostislav

    2016-01-01

    Roč. 81, č. 2 (2016), s. 524-540 ISSN 0022-4812 R&D Projects: GA ČR GAP202/11/1632 Institutional support: RVO:67985807 Keywords : substructural logic * full Lambek calculus * contraction rule * square-increasing residuated lattice * equational theory * decidability Subject RIV: BA - General Mathematics Impact factor: 0.511, year: 2016

  19. A planar calculus for infinite index subfactors

    OpenAIRE

    Penneys, David

    2011-01-01

    We develop an analog of Jones' planar calculus for II_1-factor bimodules with arbitrary left and right von Neumann dimension. We generalize to bimodules Burns' results on rotations and extremality for infinite index subfactors. These results are obtained without Jones' basic construction and the resulting Jones projections.

  20. A Planar Calculus for Infinite Index Subfactors

    Science.gov (United States)

    Penneys, David

    2013-05-01

    We develop an analog of Jones' planar calculus for II 1-factor bimodules with arbitrary left and right von Neumann dimension. We generalize to bimodules Burns' results on rotations and extremality for infinite index subfactors. These results are obtained without Jones' basic construction and the resulting Jones projections.

  1. Hybrid Logical Analyses of the Ambient Calculus

    DEFF Research Database (Denmark)

    Bolander, Thomas; Hansen, René Rydhof

    2007-01-01

    In this paper, hybrid logic is used to formulate a rational reconstruction of a previously published control flow analysis for the mobile ambients calculus and we further show how a more precise flow-sensitive analysis, that takes the ordering of action sequences into account, can be formulated...

  2. Representations in Calculus: Two Contrasting Cases.

    Science.gov (United States)

    Aspinwall, Leslie; Shaw, Kenneth L.

    2002-01-01

    Illustrates the contrasting thinking processes of two beginning calculus students' geometric and analytic schemes for the derivative function. Suggests that teachers can enhance students' understanding by continuing to demonstrate how different representations of the same mathematical concept provide additional information. (KHR)

  3. Partial differential equations and calculus of variations

    CERN Document Server

    Leis, Rolf

    1988-01-01

    This volume contains 18 invited papers by members and guests of the former Sonderforschungsbereich in Bonn (SFB 72) who, over the years, collaborated on the research group "Solution of PDE's and Calculus of Variations". The emphasis is on existence and regularity results, on special equations of mathematical physics and on scattering theory.

  4. A TENTATIVE GUIDE, DIFFERENTIAL AND INTEGRAL CALCULUS.

    Science.gov (United States)

    BRANT, VINCENT; GERARDI, WILLIAM

    THE COURSE IS INTENDED TO GO BEYOND THE REQUIREMENTS OF THE ADVANCED PLACEMENT PROGRAM IN MATHEMATICS AS DESIGNED BY THE COLLEGE ENTRANCE EXAMINATION BOARD. THE ADVANCED PLACEMENT PROGRAM CONSISTS OF A 1-YEAR COURSE COMBINING ANALYTIC GEOMETRY AND CALCULUS. PRESUPPOSED HERE ARE--A SEMESTER COURSE IN ANALYTIC GEOMETRY AND A THOROUGH KNOWLEDGE OF…

  5. A Temporal Concurrent Constraint Programming Calculus

    DEFF Research Database (Denmark)

    Palamidessi, Catuscia; Valencia Posso, Frank Darwin

    2001-01-01

    The tcc model is a formalism for reactive concurrent constraint programming. In this paper we propose a model of temporal concurrent constraint programming which adds to tcc the capability of modeling asynchronous and non-deterministic timed behavior. We call this tcc extension the ntcc calculus...

  6. Flipping a Calculus Class: One Instructor's Experience

    Science.gov (United States)

    Palmer, Katrina

    2015-01-01

    This paper describes one instructor's experiences during a year of flipping four calculus classes. The first exploration attempts to understand student expectations of a math class and their preference towards a flipped classroom. The second examines success of students from a flipped classroom, and the last investigates relationships with student…

  7. Sharks, Minnows, and Wheelbarrows: Calculus Modeling Projects

    Science.gov (United States)

    Smith, Michael D.

    2011-01-01

    The purpose of this article is to present two very active applied modeling projects that were successfully implemented in a first semester calculus course at Hollins University. The first project uses a logistic equation to model the spread of a new disease such as swine flu. The second project is a human take on the popular article "Do Dogs Know…

  8. The lambda sigma calculus and strong normalization

    DEFF Research Database (Denmark)

    Schack-Nielsen, Anders; Schürmann, Carsten

    Explicit substitution calculi can be classified into several dis- tinct categories depending on whether they are confluent, meta-confluent, strong normalization preserving, strongly normalizing, simulating, fully compositional, and/or local. In this paper we present a variant of the λσ-calculus, ...

  9. Optimal control and the calculus of variations

    CERN Document Server

    Pinch, Enid R

    1993-01-01

    This introduction to optimal control theory is intended for undergraduate mathematicians and for engineers and scientists with some knowledge of classical analysis. It includes sections on classical optimization and the calculus of variations. All the important theorems are carefully proved. There are many worked examples and exercises for the reader to attempt.

  10. Fractional calculus in bioengineering, part 3.

    Science.gov (United States)

    Magin, Richard L

    2004-01-01

    Fractional calculus (integral and differential operations of noninteger order) is not often used to model biological systems. Although the basic mathematical ideas were developed long ago by the mathematicians Leibniz (1695), Liouville (1834), Riemann (1892), and others and brought to the attention of the engineering world by Oliver Heaviside in the 1890s, it was not until 1974 that the first book on the topic was published by Oldham and Spanier. Recent monographs and symposia proceedings have highlighted the application of fractional calculus in physics, continuum mechanics, signal processing, and electromagnetics, but with few examples of applications in bioengineering. This is surprising because the methods of fractional calculus, when defined as a Laplace or Fourier convolution product, are suitable for solving many problems in biomedical research. For example, early studies by Cole (1933) and Hodgkin (1946) of the electrical properties of nerve cell membranes and the propagation of electrical signals are well characterized by differential equations of fractional order. The solution involves a generalization of the exponential function to the Mittag-Leffler function, which provides a better fit to the observed cell membrane data. A parallel application of fractional derivatives to viscoelastic materials establishes, in a natural way, hereditary integrals and the power law (Nutting/Scott Blair) stress-strain relationship for modeling biomaterials. In this review, I will introduce the idea of fractional operations by following the original approach of Heaviside, demonstrate the basic operations of fractional calculus on well-behaved functions (step, ramp, pulse, sinusoid) of engineering interest, and give specific examples from electrochemistry, physics, bioengineering, and biophysics. The fractional derivative accurately describes natural phenomena that occur in such common engineering problems as heat transfer, electrode/electrolyte behavior, and sub

  11. Characteristics of subgingival calculus detection by multiphoton fluorescence microscopy

    Science.gov (United States)

    Tung, Oi-Hong; Lee, Shyh-Yuan; Lai, Yu-Lin; Chen, How-Foo

    2011-06-01

    Subgingival calculus has been recognized as a major cause of periodontitis, which is one of the main chronic infectious diseases of oral cavities and a principal cause of tooth loss in humans. Bacteria deposited in subgingival calculus or plaque cause gingival inflammation, function deterioration, and then periodontitis. However, subgingival calculus within the periodontal pocket is a complicated and potentially delicate structure to be detected with current dental armamentaria, namely dental x-rays and dental probes. Consequently, complete removal of subgingival calculus remains a challenge to periodontal therapies. In this study, the detection of subgingival calculus employing a multiphoton autofluorescence imaging method was characterized in comparison with a one-photon confocal fluorescence imaging technique. Feasibility of such a system was studied based on fluorescence response of gingiva, healthy teeth, and calculus with and without gingiva covered. The multiphoton fluorescence technology perceived the tissue-covered subgingival calculus that cannot be observed by the one-photon confocal fluorescence method.

  12. Detection of Mycobacterium bovis in artisanal cheese in the state of Pernambuco, Brazil

    Directory of Open Access Journals (Sweden)

    Renata D. S Cezar

    2016-01-01

    Conclusion: The results of the present study highlight the need for improving sanitary measures during the production of artisanal cheese to prevent zoonotic tuberculosis in humans, resulting from the consumption of food contaminated with M. bovis.

  13. Current knowledge and pending challenges in zoonosis caused by Mycobacterium bovis: a review.

    Science.gov (United States)

    Pérez-Lago, Laura; Navarro, Yurena; García-de-Viedma, Darío

    2014-10-01

    Mycobacterium bovis is both the causative agent of bovine tuberculosis (TB) and a zoonotic pathogen. In humans, considerably fewer cases of TB are caused by M. bovis than M. tuberculosis; nevertheless, diagnostic limitations mean that currently available data on prevalence grossly underestimate the true dimension of the problem. The routes of transmission from animals to humans are well known and include direct exposure to infected animals or consumption of contaminated animal products. Application of fingerprinting tools facilitates analysis of the molecular epidemiology of M. bovis in animal-to-human and human-to-human transmission. Apart from cattle and M. bovis, other animal species and members within the M. tuberculosis complex can contribute to the zoonosis. Improvements in diagnostic techniques, application of more advanced discriminatory genotyping tools, and collaboration between veterinary and human health care researchers are key to our understanding of this zoonosis. Copyright © 2013 Elsevier Ltd. All rights reserved.

  14. Multinucleated giant cell cytokine expression in pulmonary granulomas of cattle experimentally infected with Mycobacterium bovis

    Science.gov (United States)

    Pathogenic mycobacteria of the Mycobacterium tuberculosis complex such as Mycobacterium bovis, induce a characteristic lesion known as a granulomas. Granulomas represent a specific host response to chronic antigenic stimuli, such as foreign bodies, certain bacterial components, or persistent pathoge...

  15. Bartonella bovis and Candidatus Bartonella davousti in cattle from Senegal.

    Science.gov (United States)

    Dahmani, Mustapha; Sambou, Masse; Scandola, Pierre; Raoult, Didier; Fenollar, Florence; Mediannikov, Oleg

    2017-02-01

    In Senegal, domestic ruminants play a vital role in the economy and agriculture and as a food source for people. Bartonellosis in animals is a neglected disease in the tropical regions, and little information is available about the occurrence of this disease in African ruminants. Human bartonellosis due to Bartonella quintana has been previously reported in Senegal. In this study, 199 domestic ruminants, including 104 cattle, 43 sheep, and 52 goats were sampled in villages from the Senegalese regions of Sine Saloum and Casamance. We isolated 29 Bartonella strains, all exclusively from cattle. Molecular and genetic characterization of isolated strains identified 27 strains as Bartonella bovis and two strains as potentially new species. The strains described here represent the first Bartonella strains isolated from domestic ruminants in Senegal and the first putative new Bartonella sp. isolated from cattle in Africa. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Shedding of the immunodominant P20 surface antigen of Eimeria bovis sporozoites.

    OpenAIRE

    Speer, C A; Whitmire, W M

    1989-01-01

    P20 is an immunodominant surface antigen of Eimeria bovis sporozoites. As parasites underwent merogony within cultured bovine monocytes and Madin-Darby bovine kidney (MDBK) cells, P20 appeared to be shed gradually by meronts and was absent in type 1 and 2 first-generation merozoites. Meronts of E. bovis appeared to shed P20 into the parasitophorous vacuole of bovine monocytes, whereas MDBK cells evidently released P20 into the culture medium or destroyed its antigenic determinant.

  17. Molecular Typing of Mycobacterium bovis from Cattle Reared in Midwest Brazil.

    Directory of Open Access Journals (Sweden)

    Ricardo César Tavares Carvalho

    Full Text Available Mycobacterium bovis is the causative agent of bovine tuberculosis (BTB, the pathogen responsible for serious economic impact on the livestock sector. In order to obtain data on isolated M. bovis strains and assist in the control and eradication program for BTB, a cross sectional descriptive molecular epidemiology study in the Brazilian Midwest was conducted. Through spoligotyping and 24-loci MIRU-VNTR methods, 37 clinical isolates of M. bovis circulating in the region were analyzed, 10 isolated from the state of Mato Grosso, 12 from the state of Mato Grosso do Sul and 15 from the state of Goiás. The spoligotyping analysis identified 10 distinct M. bovis profiles (SB0121 n = 14, SB0295 n = 6, SB0140 n = 6, SB0881 n = 3, SB1144 n = 2, SB1145 n = 2, SB0134 n = 1, SB1050 n = 1, SB1055 n = 1, SB1136 n = 1 grouped in six clusters and four orphan patterns. The MIRU-VNTR 24-loci grouped the same isolates in six clusters and 22 unique orphan patterns, showing higher discriminatory power than spoligotyping. When associating the results of both techniques, the isolates were grouped in five clusters and 24 unique M. bovis profiles. Among the 24-loci MIRU-VNTR evaluated, two, ETR-A and QUB 11b loci, showed high discriminatory ability (h = ≥ 0.50, while MIRU 16, MIRU 27, ETR-B, ETR-C, Mtub21 and QUB 26 loci showed moderate ability (h = 0.33 or h = 0.49 and were the most effective in evaluating the genotypic similarities among the clinical M. bovis isolate samples. Herein, the 29 patterns found amongst the 37 isolates of M. bovis circulating in the Brazilian Midwest can be due to the animal movement between regions, municipalities and farms, thus causing the spread of various M. bovis strains in herds from Midwest Brazil.

  18. Pathogenicity and genetic variation of 3 strains of Corynebacterium bovis in immunodeficient mice.

    Science.gov (United States)

    Dole, Vandana S; Henderson, Kenneth S; Fister, Richard D; Pietrowski, Michael T; Maldonado, Geomaris; Clifford, Charles B

    2013-07-01

    Corynebacterium bovis has been associated with hyperkeratotic dermatitis and acanthosis in mice. We studied 3 different strains of C. bovis: one previously described to cause hyperkeratotic dermatitis (HAC), one that infected athymic nude mice without leading to the classic clinical signs, and one of bovine origin (ATCC 7715). The 3 strains showed a few biochemical and genetic differences. Immunodeficient nude mice were housed in 3 independent isolators and inoculated with pure cultures of the 3 strains. We studied the transmission of these C. bovis studies to isolator-bedding and contact sentinels housed for 5 to 12 wk in filter-top or wire-top cages in the respective isolators. Using a 16S rRNA-based qPCR assay, we did not find consistent differences in growth and transmission among the 3 C. bovis strains, and neither the incidence nor severity of hyperkeratosis or acanthosis differed between strains. Housing in filter-top compared with wire-top cages did not alter the morbidity associated with any of the strains. Our findings confirmed the variability in the gross and histologic changes associated with C. bovis infection of mice. Although bacteriology was a sensitive method for the detection of Corynebacterium spp., standard algorithms occasionally misidentified C. bovis and several related species. Our study demonstrates that PCR of skin swabs or feces is a sensitive and specific method for the detection of C. bovis infection in mice. An rpoB-based screen of samples from North American vivaria revealed that HAC is the predominant C. bovis strain in laboratory mice.

  19. Immune response profiles of calves following vaccination with live BCG and inactivated Mycobacterium bovis vaccine candidates.

    Directory of Open Access Journals (Sweden)

    E M D L van der Heijden

    Full Text Available Conventional control and eradication strategies for bovine tuberculosis (BTB face tremendous difficulties in developing countries; countries with wildlife reservoirs, a complex wildlife-livestock-human interface or a lack of veterinary and veterinary public health surveillance. Vaccination of cattle and other species might in some cases provide the only suitable control strategy for BTB, while in others it may supplement existing test-and-slaughter schemes. However, the use of live BCG has several limitations and the global rise of HIV/AIDS infections has furthermore warranted the exploration of inactivated vaccine preparations. The aim of this study was to compare the immune response profiles in response to parenteral vaccination with live BCG and two inactivated vaccine candidates in cattle. Twenty-four mixed breed calves (Bos taurus aged 4-6 months, were allocated to one of four groups and vaccinated sub-cutaneously with live M. bovis BCG (Danish 1331, formalin-inactivated M. bovis BCG, heat-killed M. bovis or PBS/Montanide™ (control. Interferon-γ responsiveness and antibody production were measured prior to vaccination and at weekly intervals thereafter for twelve weeks. At nine weeks post-priming, animals were skin tested using tuberculins and MTBC specific protein cocktails and subsequently challenged through intranodular injection of live M. bovis BCG. The animals in the heat-killed M. bovis group demonstrated strong and sustained cell-mediated and humoral immune responses, significantly higher than the control group in response to vaccination, which may indicate a protective immune profile. Animals in this group showed reactivity to the skin test reagents, confirming good vaccine take. Lastly, although not statistically significant, recovery of BCG after challenge was lowest in the heat-killed M. bovis group. In conclusion, the parenteral heat-killed M. bovis vaccine proved to be clearly immunogenic in cattle in the present study

  20. Prosthetic Joint Infection due to Mycobacterium bovis after Intravesical Instillation of Bacillus Calmette-Guerin (BCG

    Directory of Open Access Journals (Sweden)

    Eric Gomez

    2009-01-01

    Full Text Available Intravesical instillation of Bacillus Calmette-Guerin (BCG is a treatment to prevent recurrence of superficial urothelial bladder carcinoma. Complications after bladder instillation of BCG have been reported including locally invasive and systemic infections due to dissemination of Mycobacterium bovis from the bladder. We present an uncommon case and literature review of prosthetic joint infection due to M. bovis after intravesical BCG treatment of bladder cancer.

  1. Prevalence of Mycoplasma bovis in Respiratory Tract of Cattle Slaughtered in Balochistan, Pakistan

    Directory of Open Access Journals (Sweden)

    Zafar Ahmad

    2014-01-01

    Full Text Available Cattle lungs (n=1200 obtained from abattoir of 10 districts of Balochistan were processed for isolation and identification of Mycoplasma species. A total of 156 isolates produced typical fried egg colonies on Modified Hayflick’s agar medium and 87.8% were preliminarily identified as Mycoplasma species, 12.2% species were Acholeplasmas. All the digitonin sensitive isolates were further subjected to different biochemical and PCR tests for further identification. Overall prevalence of M. bovis lungs samples obtained from slaughter house samples was 9%. Among the Mycoplasma isolates; 108 M. bovis, 29 Mycoplasma mycoides subsp. capri (Mmc and 16 M. arginini were identified through the biochemical tests. M. bovis and Mycoplasma mycoides subcluster members were further validated through PCR and RFLP. Mycoplasma mycoides subspecies mycoides small colony type (Mmm SC was not isolated from any of the lung samples. Among the Mycoplasma bovis species isolated, the highest number was observed from Quetta district (16% followed by Pishin (15%, Zhob (11 % and Kalat (10%. Conversely the lowest number of M. bovis isolates was found in Bolan (2% district followed by Jaffarabad (3%, 4%, each from Khuzdar, Mustung, Killasaifullah and 7% in Sibi district. Statistical analysis using chi square test, showed a significance difference (χ²=33.38 in the recovery of Mycoplasma bovis from the lungs of cattle slaughtered in 10 districts of Balochistan.

  2. Some aspects of the epidemiology of Babesia bovis in Santana do Livramento, Southern Brazil

    International Nuclear Information System (INIS)

    Martins, J.R.; Correa, B.L.; Cereser, V.H.; Arteche, C.C.P.; Guglielmone, A.A.

    1998-01-01

    Some aspects of the epidemiology of Babesia bovis were studied in Santana do Livramento, Rio Grande do Sul, Brazil by analysing cattle raising practices applied to 101 herds and by diagnosing B. bovis antibodies in cattle of about 11 months old using an enzyme linked immunosorbent assay. Herds with prevalence of antibodies ranging between 15% to 80% were considered at risk of babesiosis outbreaks of economic importance (enzootic instability). 53% of herds were found in enzootic instability to B. bovis. The proportion of Bos taurus and B. indicus x B. taurus herds in instability were similar (P=0.771, qui square) and the number of acaricides treatments applied yearly had no influence in the instability to B. bovis (P=0.866, chi square). Herds maintained along with sheep in a ratio < 1.5 (P=0.012, chi square); this probability was further increased in herds maintained on properties greater than 500 ha (P=0.057, chi square). High B. bovis antibody prevalence was found in B. taurus x B. indicus herds subjected to an average of 5.8 tick treatments yearly with long residual period acaricides, indicating misuse of the chemicals or tick resistance to them. The epidemiological situation to B. bovis seems to justify vaccination to avoid economic losses in herds in enzootic instability and those in enzootic stability due to low antibody prevalence. (author)

  3. A Simplified Stabilizer ZX-calculus

    Directory of Open Access Journals (Sweden)

    Miriam Backens

    2017-01-01

    Full Text Available The stabilizer ZX-calculus is a rigorous graphical language for reasoning about quantum mechanics.The language is sound and complete: a stabilizer ZX-diagram can be transformed into another one if and only if these two diagrams represent the same quantum evolution or quantum state. We show that the stabilizer ZX-calculus can be simplified, removing unnecessary equations while keeping only the essential axioms which potentially capture fundamental structures of quantum mechanics. We thus give a significantly smaller set of axioms and prove that meta-rules like 'colour symmetry' and 'upside-down symmetry', which were considered as axioms in previous versions of the language, can in fact be derived. In particular, we show that the additional symbol and one of the rules which had been recently introduced to keep track of scalars (diagrams with no inputs or outputs are not necessary.

  4. Thunks and the λ-calculus

    DEFF Research Database (Denmark)

    Hatcliff, John; Danvy, Olivier

    1997-01-01

    Thirty-five years ago, thunks were used to simulate call-by-name under call-by-value in Algol 60. Twenty years ago, Plotkin presented continuation-based simulations of call-by-name under call-by-value and vice versa in the λ-calculus. We connect all three of these classical simulations by factori......Thirty-five years ago, thunks were used to simulate call-by-name under call-by-value in Algol 60. Twenty years ago, Plotkin presented continuation-based simulations of call-by-name under call-by-value and vice versa in the λ-calculus. We connect all three of these classical simulations...

  5. Independent variables in 3 + 1 Regge calculus

    International Nuclear Information System (INIS)

    Tuckey, P.A.

    1989-01-01

    The space of metrics in 3+1 Regge calculus is discussed, and the problems of counting its dimensions, and of finding independent variables to parametrise the space, are addressed. The most general natural class of metrics is considered first, and bounds on its dimension are obtained, although no good parametrisations are found. The relationship between these metrics and those used in canonical Regge calculus is shown, and this leads to an interesting result via the Bianchi identities. A restricted class of metrics is then considered and independent variables, which parametrise these metrics and which may be computationally convenient, are given. The dimension of this space of metrics gives an improved lower bound for the dimension of the general space. (author)

  6. Differential calculus in normed linear spaces

    CERN Document Server

    Mukherjea, Kalyan

    2007-01-01

    This book presents Advanced Calculus from a geometric point of view: instead of dealing with partial derivatives of functions of several variables, the derivative of the function is treated as a linear transformation between normed linear spaces. Not only does this lead to a simplified and transparent exposition of "difficult" results like the Inverse and Implicit Function Theorems but also permits, without any extra effort, a discussion of the Differential Calculus of functions defined on infinite dimensional Hilbert or Banach spaces.The prerequisites demanded of the reader are modest: a sound understanding of convergence of sequences and series of real numbers, the continuity and differentiability properties of functions of a real variable and a little Linear Algebra should provide adequate background for understanding the book. The first two chapters cover much of the more advanced background material on Linear Algebra (like dual spaces, multilinear functions and tensor products.) Chapter 3 gives an ab ini...

  7. On the interpretation of Stratonovich calculus

    International Nuclear Information System (INIS)

    Moon, W; Wettlaufer, J S

    2014-01-01

    The Itô–Stratonovich dilemma is revisited from the perspective of the interpretation of Stratonovich calculus using shot noise. Over the long time scales of the displacement of an observable, the principal issue is how to deal with finite/zero autocorrelation of the stochastic noise. The former (non-zero) noise autocorrelation structure preserves the normal chain rule using a mid-point selection scheme, which is the basis Stratonovich calculus, whereas the instantaneous autocorrelation structure of Itô's approach does not. By considering the finite decay of the noise correlations on time scales very short relative to the overall displacement times of the observable, we suggest a generalization of the integral Taylor expansion criterion of Wong and Zakai (1965 Ann. Math. Stat. 36 1560–4) for the validity of the Stratonovich approach. (paper)

  8. Two cosmological solutions of Regge calculus

    International Nuclear Information System (INIS)

    Lewis, S.M.

    1982-01-01

    Two cosmological solutions of Regge calculus are presented which correspond to the flat Friedmann-Robertson-Walker and the Kasner solutions of general relativity. By taking advantage of the symmetries that are present, I am able to show explicitly that a limit of Regge calculus does yield Einstein's equations for these cases. The method of averaging these equations when taking limits is important, especially for the Kasner model. I display the leading error term that arises from keeping the Regge equations in discrete form rather than using their continuum limit. In particular, this work shows that for the ''Reggeized'' Friedmann model the minimum volume is a velocity-dominated singularity as in the continuum Friedmann model. However, unlike the latter, the Regge version has a nonzero minimum volume

  9. Semiclassical dynamics and magnetic Weyl calculus

    International Nuclear Information System (INIS)

    Lein, Maximilian Stefan

    2011-01-01

    Weyl quantization and related semiclassical techniques can be used to study conduction properties of crystalline solids subjected to slowly-varying, external electromagnetic fields. The case where the external magnetic field is constant, is not covered by existing theory as proofs involving usual Weyl calculus break down. This is the regime of the so-called quantum Hall effect where quantization of transverse conductance is observed. To rigorously derive semiclassical equations of motion, one needs to systematically develop a magnetic Weyl calculus which contains a semiclassical parameter. Mathematically, the operators involved in the analysis are magnetic pseudodifferential operators, a topic which by itself is of interest for the mathematics and mathematical physics community alike. Hence, we will devote two additional chapters to further understanding of properties of those operators. (orig.)

  10. Semiclassical dynamics and magnetic Weyl calculus

    Energy Technology Data Exchange (ETDEWEB)

    Lein, Maximilian Stefan

    2011-01-19

    Weyl quantization and related semiclassical techniques can be used to study conduction properties of crystalline solids subjected to slowly-varying, external electromagnetic fields. The case where the external magnetic field is constant, is not covered by existing theory as proofs involving usual Weyl calculus break down. This is the regime of the so-called quantum Hall effect where quantization of transverse conductance is observed. To rigorously derive semiclassical equations of motion, one needs to systematically develop a magnetic Weyl calculus which contains a semiclassical parameter. Mathematically, the operators involved in the analysis are magnetic pseudodifferential operators, a topic which by itself is of interest for the mathematics and mathematical physics community alike. Hence, we will devote two additional chapters to further understanding of properties of those operators. (orig.)

  11. Calculus teaching and learning in South Korea

    OpenAIRE

    Natanael Karjanto

    2013-01-01

    This article discusses an experience of teaching Calculus classes for the freshmen students enrolled at Sungkyunkwan University, one of the private universities in South Korea. The teaching and learning approach is a balance combination between the teacher-oriented traditional style of lecturing and other activities that encourage students for active learning and classroom participation. Based on the initial observation during several semesters, some anecdotal evidences show that students'...

  12. Calculus teaching and learning in South Korea

    OpenAIRE

    Karjanto, N.

    2015-01-01

    This article discusses an experience of teaching Calculus classes for the freshmen students enrolled at Sungkyunkwan University, one of the private universities in South Korea. The teaching and learning approach is a balance combination between the teacher-oriented traditional style of lecturing and other activities that encourage students for active learning and classroom participation. Based on the initial observation during several semesters, some anecdotal evidences show that students' le...

  13. Some aspects of q-boson calculus

    International Nuclear Information System (INIS)

    Smirnov, Yu.F.; Kibler, M.R.

    1992-10-01

    The Jordan-Schwinger calculus is discussed, using deformed bosons. This work constitutes a first step toward a complete study of the SU q (2) unit tensor. The objective is to find a realization of the components of this tensor in terms of q-bosons. The q-deformed Schwinger algebra relative to SU q (2) is defined, and an algorithm for producing recurrent relations between Clebsch-Gordan coefficients for SU q (2) is given. (K.A.) 18 refs

  14. Differential calculus on quantized simple Lie groups

    International Nuclear Information System (INIS)

    Jurco, B.

    1991-01-01

    Differential calculi, generalizations of Woronowicz's four-dimensional calculus on SU q (2), are introduced for quantized classical simple Lie groups in a constructive way. For this purpose, the approach of Faddeev and his collaborators to quantum groups was used. An equivalence of Woronowicz's enveloping algebra generated by the dual space to the left-invariant differential forms and the corresponding quantized universal enveloping algebra, is obtained for our differential calculi. Real forms for q ε R are also discussed. (orig.)

  15. Time-evolution problem in Regge calculus

    International Nuclear Information System (INIS)

    Sorkin, R.

    1975-01-01

    The simplectic approximation to Einstein's equations (''Regge calculus'') is derived by considering the net to be actually a (singular) Riemannian manifold. Specific nets for open and closed spaces are introduced in terms of which one can formulate the general time-evolution problem, which thereby reduces to the repeated solution of finite sets of coupled nonlinear (algebraic) equations. The initial-value problem is also formulated in simplectic terms

  16. Inclusive central region in perturbative Reggeon calculus

    International Nuclear Information System (INIS)

    Pajares, C.; Pascual, R.

    1976-01-01

    The single-particle inclusive cross section and the correlation function are studied in the perturbative approach to Gribov's Reggeon calculus; the leading contributions to both functions are evaluated. The large energy rise of the inclusive cross section appears as a consequence of the Pomerons having an intercept larger than 1. The same set of parameters which describes correctly the cross-section data and the triple-Regge region also describes the inclusive data in the central region

  17. Earlinet single calculus chain: new products overview

    Science.gov (United States)

    D'Amico, Giuseppe; Mattis, Ina; Binietoglou, Ioannis; Baars, Holger; Mona, Lucia; Amato, Francesco; Kokkalis, Panos; Rodríguez-Gómez, Alejandro; Soupiona, Ourania; Kalliopi-Artemis, Voudouri

    2018-04-01

    The Single Calculus Chain (SCC) is an automatic and flexible tool to analyze raw lidar data using EARLINET quality assured retrieval algorithms. It has been already demonstrated the SCC can retrieve reliable aerosol backscatter and extinction coefficient profiles for different lidar systems. In this paper we provide an overview of new SCC products like particle linear depolarization ratio, cloud masking, aerosol layering allowing relevant improvements in the atmospheric aerosol characterization.

  18. Equivariant calculus in the differential envelope

    International Nuclear Information System (INIS)

    Kastler, D.

    1991-01-01

    The author shows how Z/2-graded cyclic cohomology is related to the equivariant calculus of S. Klimek, W. Kondracki, and A. Lesniewski (HUTMP 90/B247 (1990)). He uses the differential envelope of a complex unital differential algebra. After a presentation of fiber-preserved operators on equivariant functions valued in this algebra on a group he considers certain operators on this algebra. Finally he discusses explicitly the case G=Z/2. (HSI)

  19. Equivariant calculus in the differential envelope

    Energy Technology Data Exchange (ETDEWEB)

    Kastler, D. (Centre National de la Recherche Scientifique, 13 - Marseille (France). Centre de Physique Theorique)

    1991-01-01

    The author shows how Z/2-graded cyclic cohomology is related to the equivariant calculus of S. Klimek, W. Kondracki, and A. Lesniewski (HUTMP 90/B247 (1990)). He uses the differential envelope of a complex unital differential algebra. After a presentation of fiber-preserved operators on equivariant functions valued in this algebra on a group he considers certain operators on this algebra. Finally he discusses explicitly the case G=Z/2. (HSI).

  20. Double dumb-bell calculus in childhood

    Directory of Open Access Journals (Sweden)

    Joshi Prashant

    2009-01-01

    Full Text Available An eight-year old male was admitted with complaints of right scrotal swelling, dysuria and intermittent retention of urine for 10 days. On per-rectal examination, a hard mass was palpable in the posterior urethra. An X-ray (KUB of the abdomen revealed a double dumb-bell calculus at the base of bladder, extending into the posterior urethra. A cystolithotomy via the suprapubic approach was successfully curative.

  1. Neutrix calculus and finite quantum field theory

    International Nuclear Information System (INIS)

    Ng, Y Jack; Dam, H van

    2005-01-01

    In general, quantum field theories (QFT) require regularizations and infinite renormalizations due to ultraviolet divergences in their loop calculations. Furthermore, perturbation series in theories like quantum electrodynamics are not convergent series, but are asymptotic series. We apply neutrix calculus, developed in connection with asymptotic series and divergent integrals, to QFT, obtaining finite renormalizations. While none of the physically measurable results in renormalizable QFT is changed, quantum gravity is rendered more manageable in the neutrix framework. (letter to the editor)

  2. Introduction to the calculus of variations

    CERN Document Server

    Sagan, Hans

    1992-01-01

    Excellent text provides basis for thorough understanding of the problems, methods and techniques of the calculus of variations and prepares readers for the study of modern optimal control theory. Treatment limited to extensive coverage of single integral problems in one and more unknown functions. Carefully chosen variational problems and over 400 exercises. ""Should find wide acceptance as a text and reference.""-American Mathematical Monthly. 1969 edition. Bibliography.

  3. Geometrical foundations of tensor calculus and relativity

    OpenAIRE

    Schuller , Frédéric; Lorent , Vincent

    2006-01-01

    Manifolds, particularly space curves: basic notions 1 The first groundform, the covariant metric tensor 11 The second groundform, Meusnier's theorem 19 Transformation groups in the plane 28 Co- and contravariant components for a special affine transformation in the plane 29 Surface vectors 32 Elements of tensor calculus 36 Generalization of the first groundform to the space 46 The covariant (absolute) derivation 57 Examples from elasticity theory 61 Geodesic lines 63 Main curvatur...

  4. Feynman's operational calculus and beyond noncommutativity and time-ordering

    CERN Document Server

    Johnson, George W; Nielsen, Lance

    2015-01-01

    This book is aimed at providing a coherent, essentially self-contained, rigorous and comprehensive abstract theory of Feynman's operational calculus for noncommuting operators. Although it is inspired by Feynman's original heuristic suggestions and time-ordering rules in his seminal 1951 paper An operator calculus having applications in quantum electrodynamics, as will be made abundantly clear in the introduction (Chapter 1) and elsewhere in the text, the theory developed in this book also goes well beyond them in a number of directions which were not anticipated in Feynman's work. Hence, the second part of the main title of this book. The basic properties of the operational calculus are developed and certain algebraic and analytic properties of the operational calculus are explored. Also, the operational calculus will be seen to possess some pleasant stability properties. Furthermore, an evolution equation and a generalized integral equation obeyed by the operational calculus are discussed and connections wi...

  5. Natural Babesia bovis Infection in Water Buffaloes (Bubalus bubalis and Crossbred Cattle under Field Conditions in Egypt: a Preliminary Study.

    Directory of Open Access Journals (Sweden)

    Yasser Mahmmod

    2014-06-01

    Full Text Available There is a little or no data available on the natural Babesia bovis (B. bovis infection in water buffaloes (Bubalus bubalis comparing to the available one for cattle. This study was conducted to investigate the natural B. bovis infection in water buffaloes in comparison to crossbred cattle under field conditions in Egypt.A total of 35 buffaloes and cattle were clinically and laboratory investigated from March to June 2008. Twenty-nine buffaloes and cattle out of 35 were naturally infected with B. bovis and showed signs of bovine babesiosis. Three cows and three buffaloes showed no clinical signs and were free from external, internal, and blood parasites served as control group.Babesia bovis-infected cattle showed typical signs of bovine babesiosis while B. bovis-infected buffaloes showed a milder form (less severe of the clinical signs. Advanced cases of cattle showed dark brown to dark red (coffee-color urine, hemoglobinuria and nervous manifestations while these manifestations were not detected in the infected buffaloes. Hematological changes in both species however, these changes were less significant in buffaloes than those reported in cattle.This paper documents the first description of natural B. bovis infection in water buffaloes which were found to be more likely to be tolerant than cattle to the natural clinical infection with B. bovis and its subsequent haematological changes. Our finding may lead to a better understanding of the disease pattern of B. bovis infection under field conditions in buffaloes.

  6. T- and B-cell response analysis following calf immunisation with experimental Mycoplasma bovis vaccine containing saponin and lysozyme dimer

    Directory of Open Access Journals (Sweden)

    Dudek Katarzyna

    2017-12-01

    Full Text Available Introduction:Mycoplasma bovis is a well-known cause of various disorders in cattle, such as pneumonia, arthritis, mastitis kerato-conjunctivitis, pharyngitis, laryngitis, otitis media, meningitis, and reproductive disorders. There are no commercial vaccines against M. bovis in Europe, therefore, experimental ones are still under investigation. The aim of this study was to evaluate the effect of experimental M. bovis vaccine, containing the Polish field M. bovis strain as well as saponin and lysozyme dimer adjuvants, on the T- and B-cell response in calves.

  7. Molecular and serologic evidence for Babesia bovis-like parasites in white-tailed deer (Odocoileus virginianus) in south Texas.

    Science.gov (United States)

    Ramos, Christina M; Cooper, Susan M; Holman, Patricia J

    2010-09-20

    The current study was undertaken to determine if white-tailed deer in south Texas harbor Babesia bovis, a causative agent of bovine babesiosis. Blood samples from free-ranging white-tailed deer (Odocoileus virginianus) on two ranches in LaSalle and Webb Counties were screened for B. bovis and other hemoparasites by the polymerase chain reaction (PCR) to detect the piroplasm 18S rDNA. Serology was conducted on selected samples to detect antibody activity to B. bovis by the immunofluorescent antibody test (IFAT). PCR revealed that 16% of the LaSalle County samples and 4% of the Webb County samples were positive for B. bovis. Five of the LaSalle County and the two Webb County B. bovis 18S rDNA amplicons were cloned and sequenced. The resulting clones shared 99% identity to B. bovis 18S rRNA gene sequences derived from cattle isolates. Weak seroreactivity to B. bovis was shown by the IFAT. The samples were also screened for additional hemoparasites of deer including Theileria cervi, Babesia odocoilei and other Babesia spp. A genotypically unique Theileria sp. was found, along with T. cervi and B. odocoilei. The finding of putative B. bovis in white-tailed deer necessitates further study to determine if deer may act as a transient host or even a reservoir of infection for B. bovis pathogenic to cattle.

  8. The Complex Gradient Operator and the CR-Calculus

    OpenAIRE

    Kreutz-Delgado, Ken

    2009-01-01

    A thorough discussion and development of the calculus of real-valued functions of complex-valued vectors is given using the framework of the Wirtinger Calculus. The presented material is suitable for exposition in an introductory Electrical Engineering graduate level course on the use of complex gradients and complex Hessian matrices, and has been successfully used in teaching at UC San Diego. Going beyond the commonly encountered treatments of the first-order complex vector calculus, second-...

  9. Application of Quantum Process Calculus to Higher Dimensional Quantum Protocols

    Directory of Open Access Journals (Sweden)

    Simon J. Gay

    2014-07-01

    Full Text Available We describe the use of quantum process calculus to describe and analyze quantum communication protocols, following the successful field of formal methods from classical computer science. We have extended the quantum process calculus to describe d-dimensional quantum systems, which has not been done before. We summarise the necessary theory in the generalisation of quantum gates and Bell states and use the theory to apply the quantum process calculus CQP to quantum protocols, namely qudit teleportation and superdense coding.

  10. Supergravity tensor calculus in 5D from 6D

    International Nuclear Information System (INIS)

    Kugo, Taichiro; Ohashi, Keisuke

    2000-01-01

    Supergravity tensor calculus in five spacetime dimensions is derived by dimensional reduction from the d=6 superconformal tensor calculus. In particular, we obtain an off-shell hypermultiplet in 5D from the on-shell hypermultiplet in 6D. Our tensor calculus retains the dilatation gauge symmetry, so that it is a trivial gauge fixing to make the Einstein term canonical in a general matter-Yang-Mills-supergravity coupled system. (author)

  11. Transfected Babesia bovis Expressing a Tick GST as a Live Vector Vaccine

    Science.gov (United States)

    Oldiges, Daiane P.; Laughery, Jacob M.; Tagliari, Nelson Junior; Leite Filho, Ronaldo Viana; Davis, William C.; da Silva Vaz, Itabajara; Termignoni, Carlos; Knowles, Donald P.; Suarez, Carlos E.

    2016-01-01

    The Rhipicephalus microplus tick is a notorious blood-feeding ectoparasite of livestock, especially cattle, responsible for massive losses in animal production. It is the main vector for transmission of pathogenic bacteria and parasites, including Babesia bovis, an intraerythrocytic apicomplexan protozoan parasite responsible for bovine Babesiosis. This study describes the development and testing of a live B. bovis vaccine expressing the protective tick antigen glutathione-S-transferase from Haemaphysalis longicornis (HlGST). The B. bovis S74-T3B parasites were electroporated with a plasmid containing the bidirectional Ef-1α (elongation factor 1 alpha) promoter of B. bovis controlling expression of two independent genes, the selectable marker GFP-BSD (green fluorescent protein–blasticidin deaminase), and HlGST fused to the MSA-1 (merozoite surface antigen 1) signal peptide from B. bovis. Electroporation followed by blasticidin selection resulted in the emergence of a mixed B. bovis transfected line (termed HlGST) in in vitro cultures, containing parasites with distinct patterns of insertion of both exogenous genes, either in or outside the Ef-1α locus. A B. bovis clonal line termed HlGST-Cln expressing intracellular GFP and HlGST in the surface of merozoites was then derived from the mixed parasite line HlGST using a fluorescent activated cell sorter. Two independent calf immunization trials were performed via intravenous inoculation of the HlGST-Cln and a previously described control consisting of an irrelevant transfected clonal line of B. bovis designated GFP-Cln. The control GFP-Cln line contains a copy of the GFP-BSD gene inserted into the Ef-1α locus of B. bovis in an identical fashion as the HIGST-Cln parasites. All animals inoculated with the HlGST-Cln and GFP-Cln transfected parasites developed mild babesiosis. Tick egg fertility and fully engorged female tick weight was reduced significantly in R. microplus feeding on HlGST-Cln-immunized calves

  12. Transfected Babesia bovis Expressing a Tick GST as a Live Vector Vaccine.

    Directory of Open Access Journals (Sweden)

    Daiane P Oldiges

    2016-12-01

    Full Text Available The Rhipicephalus microplus tick is a notorious blood-feeding ectoparasite of livestock, especially cattle, responsible for massive losses in animal production. It is the main vector for transmission of pathogenic bacteria and parasites, including Babesia bovis, an intraerythrocytic apicomplexan protozoan parasite responsible for bovine Babesiosis. This study describes the development and testing of a live B. bovis vaccine expressing the protective tick antigen glutathione-S-transferase from Haemaphysalis longicornis (HlGST. The B. bovis S74-T3B parasites were electroporated with a plasmid containing the bidirectional Ef-1α (elongation factor 1 alpha promoter of B. bovis controlling expression of two independent genes, the selectable marker GFP-BSD (green fluorescent protein-blasticidin deaminase, and HlGST fused to the MSA-1 (merozoite surface antigen 1 signal peptide from B. bovis. Electroporation followed by blasticidin selection resulted in the emergence of a mixed B. bovis transfected line (termed HlGST in in vitro cultures, containing parasites with distinct patterns of insertion of both exogenous genes, either in or outside the Ef-1α locus. A B. bovis clonal line termed HlGST-Cln expressing intracellular GFP and HlGST in the surface of merozoites was then derived from the mixed parasite line HlGST using a fluorescent activated cell sorter. Two independent calf immunization trials were performed via intravenous inoculation of the HlGST-Cln and a previously described control consisting of an irrelevant transfected clonal line of B. bovis designated GFP-Cln. The control GFP-Cln line contains a copy of the GFP-BSD gene inserted into the Ef-1α locus of B. bovis in an identical fashion as the HIGST-Cln parasites. All animals inoculated with the HlGST-Cln and GFP-Cln transfected parasites developed mild babesiosis. Tick egg fertility and fully engorged female tick weight was reduced significantly in R. microplus feeding on Hl

  13. Everyday calculus discovering the hidden math all around us

    CERN Document Server

    Fernandez, Oscar E

    2014-01-01

    Calculus. For some of us, the word conjures up memories of ten-pound textbooks and visions of tedious abstract equations. And yet, in reality, calculus is fun, accessible, and surrounds us everywhere we go. In Everyday Calculus, Oscar Fernandez shows us how to see the math in our coffee, on the highway, and even in the night sky. Fernandez uses our everyday experiences to skillfully reveal the hidden calculus behind a typical day's events. He guides us through how math naturally emerges from simple observations-how hot coffee cools down, for example-and in discussions of over fifty familia

  14. Dental calculus image based on optical coherence tomography

    Science.gov (United States)

    Hsieh, Yao-Sheng; Ho, Yi-Ching; Lee, Shyh-Yuan; Chuang, Ching-Cheng; Wang, Chun-Yang; Sun, Chia-Wei

    2011-03-01

    In this study, the dental calculus was characterized and imaged by means of swept-source optical coherence tomography (SSOCT). The refractive indices of enamel, dentin, cementum and calculus were measured as 1.625+/-0.024, 1.534+/-0.029, 1.570+/-0.021 and 1.896+/-0.085, respectively. The dental calculus lead strong scattering property and thus the region can be identified under enamel with SSOCT imaging. An extracted human tooth with calculus was covered by gingiva tissue as in vitro sample for SSOCT imaging.

  15. Malliavin Calculus With Applications to Stochastic Partial Differential Equations

    CERN Document Server

    Sanz-Solé, Marta

    2005-01-01

    Developed in the 1970s to study the existence and smoothness of density for the probability laws of random vectors, Malliavin calculus--a stochastic calculus of variation on the Wiener space--has proven fruitful in many problems in probability theory, particularly in probabilistic numerical methods in financial mathematics.This book presents applications of Malliavin calculus to the analysis of probability laws of solutions to stochastic partial differential equations driven by Gaussian noises that are white in time and coloured in space. The first five chapters introduce the calculus itself

  16. A Calculus of Communicating Systems with Label Passing

    DEFF Research Database (Denmark)

    Engberg, Uffe Henrik; Nielsen, Mogens

    Milner's Calculus of Communicating Systems (CCS) is extended with a mechanism for label passing - as an attempt to remedy some of the shortcomings of CCS w.r.t. dynamic change of agent interconnections. In the extended calculus, restriction is viewed formally as a binder, and the calculus allows...... dynamic change of scope (of label) in connection with communication. It is proved that algebraic properties of strong (and observational) equivalence for CCS are preserved by the extension. Examples illustrating the expressive power of the calculus and its methods for reasoning are given....

  17. Renal vein thrombosis mimicking urinary calculus: a dilemma of diagnosis.

    Science.gov (United States)

    Wang, Yimin; Chen, Shanwen; Wang, Wei; Liu, Jianyong; Jin, Baiye

    2015-07-02

    Renal vein thrombosis (RVT) with flank pain, and hematuria, is often mistaken with renal colic originating from ureteric or renal calculus. Especially in young and otherwise healthy patients, clinicians are easily misled by clinical presentation and calcified RVT. A 38-year-old woman presented with flank pain and hematuria suggestive of renal calculus on ultrasound. She underwent extracorporeal shock wave lithotripsy that failed, leading to the recommendation that percutaneous lithotomy was necessary to remove the renal calculus. In preoperative view of the unusual shape of the calculus without hydronephrosis, noncontrast computed tomography was taken and demonstrated left ureteric calculus. However computed tomography angiography revealed, to our surprise, a calcified RVT that was initially thought to be a urinary calculus. This case shows that a calcified RVT might mimic a urinary calculus on conventional ultrasonography and ureteric calculus on noncontrast computed tomography. Subsequent computed tomography angiography disclosed that a calcified RVT caused the imaging findings, thus creating a potentially dangerous clinical pitfall. Hence, it is suggested that the possibility of a RVT needs to be considered in the differential diagnosis whenever one detects an uncommon shape for a urinary calculus.

  18. Command injection attacks, continuations, and the Lambek calculus

    Directory of Open Access Journals (Sweden)

    Hayo Thielecke

    2016-06-01

    Full Text Available This paper shows connections between command injection attacks, continuations, and the Lambek calculus: certain command injections, such as the tautology attack on SQL, are shown to be a form of control effect that can be typed using the Lambek calculus, generalizing the double-negation typing of continuations. Lambek's syntactic calculus is a logic with two implicational connectives taking their arguments from the left and right, respectively. These connectives describe how strings interact with their left and right contexts when building up syntactic structures. The calculus is a form of propositional logic without structural rules, and so a forerunner of substructural logics like Linear Logic and Separation Logic.

  19. Pre-calculus 1,001 practice problems for dummies

    CERN Document Server

    Sterling, Mary Jane; Sterling

    2014-01-01

    Prepare for calculus the smart way, with customizable pre-calculus practice 1,001 Pre-Calculus Practice Problems For Dummies offers 1,001 opportunities to gain confidence in your math skills. Much more than a workbook, this study aid provides pre-calculus problems ranked from easy to advanced, with detailed explanations and step-by-step solutions for each one. The companion website gives you free online access to all 1,001 practice problems and solutions, and you can track your progress and ID where you should focus your study time. Accessible on the go by smart phone, tablet, o

  20. Development and host compatibility of plasmids for two important ruminant pathogens, Mycoplasma bovis and Mycoplasma agalactiae.

    Directory of Open Access Journals (Sweden)

    Shukriti Sharma

    Full Text Available Mycoplasma bovis is a cause of pneumonia, mastitis, arthritis and otitis media in cattle throughout the world. However, despite its clinical significance, there is a paucity of tools to genetically manipulate it, impeding our capacity to further explore the molecular basis of its virulence. To address this limitation, we developed a series of homologous and heterologous replicable plasmids from M. bovis and M. agalactiae. The shortest replicable oriC plasmid based on the region downstream of dnaA in M. bovis was 247 bp and contained two DnaA boxes, while oriC plasmids based on the region downstream of dnaA in M. agalactiae strains 5632 and PG2 were 219 bp and 217 bp in length, respectively, and contained only a single DnaA box. The efficiency of transformation in M. bovis and M. agalactiae was inversely correlated with the size of the oriC region in the construct, and, in general, homologous oriC plasmids had a higher transformation efficiency than heterologous oriC plasmids. The larger pWholeoriC45 and pMM21-7 plasmids integrated into the genomic oriC region of M. bovis, while the smaller oriC plasmids remained extrachromosomal for up to 20 serial passages in selective media. Although specific gene disruptions were not be achieved in M. bovis in this study, the oriC plasmids developed here could still be useful as tools in complementation studies and for expression of exogenous genes in both M. bovis and M. agalactiae.

  1. Characterization of Streptococcus bovis from the rumen of the dromedary camel and Rusa deer.

    Science.gov (United States)

    Ghali, M B; Scott, P T; Al Jassim, R A M

    2004-01-01

    Isolation and characterization of Streptococcus bovis from the dromedary camel and Rusa deer. Bacteria were isolated from the rumen contents of four camels and two deer fed lucerne hay by culturing on the semi-selective medium MRS agar. Based on Gram morphology and RFLP analysis seven isolates, MPR1, MPR2, MPR3, MPR4, MPR5, RD09 and RD11 were selected and putatively identified as Streptococcus. The identity of these isolates was later confirmed by comparative DNA sequence analysis of the 16S rRNA gene with the homologous sequence from S. bovis strains, JB1, C14b1, NCFB2476, SbR1, SbR7 and Sb5, from cattle and sheep, and the Streptococcus equinus strain NCD01037T. The percentage similarity amongst all strains was >99%, confirming the identification of the camel isolates as S. bovis. The strains were further characterized by their ability to utilize a range of carbohydrates, the production of volatile fatty acids (VFA) and lactate and the determination of the doubling time in basal medium 10 supplemented with glucose. All the isolates produced l-lactate as a major fermentation end product, while four of five camel isolates produced VFA. The range of carbohydrates utilized by all the strains tested, including those from cattle and sheep were identical, except that all camel isolates and the deer isolate RD11 were additionally able to utilize arabinose. Streptococcus bovis was successfully isolated from the rumen of camels and deer, and shown by molecular and biochemical characterization to be almost identical to S. bovis isolates from cattle and sheep. Streptococcus bovis is considered a key lactic acid producing bacterium from the gastrointestinal tract of ruminants, and has been implicated as a causative agent of lactic acidosis. This study is the first report of the isolation and characterization of S. bovis from the dromedary camel and Rusa deer, and suggests a major contributive role of this bacterium to fermentative acidosis.

  2. Susceptibilities of Mycoplasma bovis, Mycoplasma dispar, and Ureaplasma diversum strains to antimicrobial agents in vitro.

    Science.gov (United States)

    ter Laak, E A; Noordergraaf, J H; Verschure, M H

    1993-02-01

    The purpose of this study was to determine the susceptibility of various strains of Mycoplasma bovis, Mycoplasma dispar, and Ureaplasma diversum, which are prevalent causes of pneumonia in calves, to 16 antimicrobial agents in vitro. The MICs of the antimicrobial agents were determined by a serial broth dilution method for 16 field strains and the type strain of M. bovis, for 19 field strains and the type strain of M. dispar, and for 17 field strains of U. diversum. Final MICs for M. bovis and M. dispar were read after 7 days and final MICs for U. diversum after 1 to 2 days. All strains tested were susceptible to tylosin, kitasamycin, and tiamulin but were resistant to nifuroquine and streptomycin. Most strains of U. diversum were intermediately susceptible to oxytetracycline but fully susceptible to chlortetracycline; most strains of M. bovis and M. dispar, however, were resistant to both agents. Strains of M. dispar and U. diversum were susceptible to doxycycline and minocycline, but strains of M. bovis were only intermediately susceptible. Susceptibility or resistance to chloramphenicol, spiramycin, spectinomycin, lincomycin, or enrofloxacin depended on the species but was not equal for the three species. The type strains of M. bovis and M. dispar were more susceptible to various antimicrobial agents, including tetracyclines, than the field strains. This finding might indicate that M. bovis and M. dispar strains are becoming resistant to these agents. Antimicrobial agents that are effective in vitro against all three mycoplasma species can be considered for treating mycoplasma infections in pneumonic calves. Therefore, tylosin, kitasamycin, and tiamulin may be preferred over oxytetracycline and chlortetracycline.

  3. Development and Host Compatibility of Plasmids for Two Important Ruminant Pathogens, Mycoplasma bovis and Mycoplasma agalactiae

    Science.gov (United States)

    Sharma, Shukriti; Citti, Chistine; Sagné, Eveline; Marenda, Marc S.

    2015-01-01

    Mycoplasma bovis is a cause of pneumonia, mastitis, arthritis and otitis media in cattle throughout the world. However, despite its clinical significance, there is a paucity of tools to genetically manipulate it, impeding our capacity to further explore the molecular basis of its virulence. To address this limitation, we developed a series of homologous and heterologous replicable plasmids from M. bovis and M. agalactiae. The shortest replicable oriC plasmid based on the region downstream of dnaA in M. bovis was 247 bp and contained two DnaA boxes, while oriC plasmids based on the region downstream of dnaA in M. agalactiae strains 5632 and PG2 were 219 bp and 217 bp in length, respectively, and contained only a single DnaA box. The efficiency of transformation in M. bovis and M. agalactiae was inversely correlated with the size of the oriC region in the construct, and, in general, homologous oriC plasmids had a higher transformation efficiency than heterologous oriC plasmids. The larger pWholeoriC45 and pMM21-7 plasmids integrated into the genomic oriC region of M. bovis, while the smaller oriC plasmids remained extrachromosomal for up to 20 serial passages in selective media. Although specific gene disruptions were not be achieved in M. bovis in this study, the oriC plasmids developed here could still be useful as tools in complementation studies and for expression of exogenous genes in both M. bovis and M. agalactiae. PMID:25746296

  4. Gliding motility of Babesia bovis merozoites visualized by time-lapse video microscopy.

    Directory of Open Access Journals (Sweden)

    Masahito Asada

    Full Text Available BACKGROUND: Babesia bovis is an apicomplexan intraerythrocytic protozoan parasite that induces babesiosis in cattle after transmission by ticks. During specific stages of the apicomplexan parasite lifecycle, such as the sporozoites of Plasmodium falciparum and tachyzoites of Toxoplasma gondii, host cells are targeted for invasion using a unique, active process termed "gliding motility". However, it is not thoroughly understood how the merozoites of B. bovis target and invade host red blood cells (RBCs, and gliding motility has so far not been observed in the parasite. METHODOLOGY/PRINCIPAL FINDINGS: Gliding motility of B. bovis merozoites was revealed by time-lapse video microscopy. The recorded images revealed that the process included egress of the merozoites from the infected RBC, gliding motility, and subsequent invasion into new RBCs. The gliding motility of B. bovis merozoites was similar to the helical gliding of Toxoplasma tachyzoites. The trails left by the merozoites were detected by indirect immunofluorescence assay using antiserum against B. bovis merozoite surface antigen 1. Inhibition of gliding motility by actin filament polymerization or depolymerization indicated that the gliding motility was driven by actomyosin dependent process. In addition, we revealed the timing of breakdown of the parasitophorous vacuole. Time-lapse image analysis of membrane-stained bovine RBCs showed formation and breakdown of the parasitophorous vacuole within ten minutes of invasion. CONCLUSIONS/SIGNIFICANCE: This is the first report of the gliding motility of B. bovis. Since merozoites of Plasmodium parasites do not glide on a substrate, the gliding motility of B. bovis merozoites is a notable finding.

  5. Toxicogenomic response of Mycobacterium bovis BCG to peracetic acid and a comparative analysis of the M. bovis BCG response to three oxidative disinfectants.

    Science.gov (United States)

    Nde, Chantal W; Toghrol, Freshteh; Jang, Hyeung-Jin; Bentley, William E

    2011-04-01

    Tuberculosis is a leading cause of death worldwide and infects thousands of Americans annually. Mycobacterium bovis causes tuberculosis in humans and several animal species. Peracetic acid is an approved tuberculocide in hospital and domestic environments. This study presents for the first time the transcriptomic changes in M. bovis BCG after treatment with 0.1 mM peracetic acid for 10 and 20 min. This study also presents for the first time a comparison among the transcriptomic responses of M. bovis BCG to three oxidative disinfectants: peracetic acid, sodium hypochlorite, and hydrogen peroxide after 10 min of treatment. Results indicate that arginine biosynthesis, virulence, and oxidative stress response genes were upregulated after both peracetic acid treatment times. Three DNA repair genes were downregulated after 10 and 20 min and cell wall component genes were upregulated after 20 min. The devR-devS signal transduction system was upregulated after 10 min, suggesting a role in the protection against peracetic acid treatment. Results also suggest that peracetic acid and sodium hypochlorite both induce the expression of the ctpF gene which is upregulated in hypoxic environments. Further, this study reveals that in M. bovis BCG, hydrogen peroxide and peracetic acid both induce the expression of katG involved in oxidative stress response and the mbtD and mbtI genes involved in iron regulation/virulence.

  6. Improving Student Success in Calculus I Using a Co-Requisite Calculus I Lab

    Science.gov (United States)

    Vestal, Sharon Schaffer; Brandenburger, Thomas; Furth, Alfred

    2015-01-01

    This paper describes how one university mathematics department was able to improve student success in Calculus I by requiring a co-requisite lab for certain groups of students. The groups of students required to take the co-requisite lab were identified by analyzing student data, including Math ACT scores, ACT Compass Trigonometry scores, and…

  7. Success in Introductory Calculus: The Role of High School and Pre-Calculus Preparation

    Science.gov (United States)

    Ayebo, Abraham; Ukkelberg, Sarah; Assuah, Charles

    2017-01-01

    Calculus at the college level has significant potential to serve as a pump for increasing the number of students majoring in STEM fields. It is a foundation course for all STEM majors and, if mastered well, should provide students with a positive and successful first-year experience and gateway into more advanced courses. Studies have shown that a…

  8. Unfolding Semantics of the Untyped λ-Calculus with lectrec-Calculus with letrec

    NARCIS (Netherlands)

    Rochel, J.

    2016-01-01

    We investigate the relationship between finite terms in lambda-letrec, the lambda calculus with letrec, and the infinite lambda terms they express. We say that a lambda-letrec term expresses a lambda term if the latter can be obtained as an infinite unfolding of the former. Unfolding is the process

  9. Transcriptional analysis of genetic region RvD1 of Mycobacterium bovis

    Directory of Open Access Journals (Sweden)

    Víctor Manuel Tibatá R.

    2004-07-01

    Full Text Available Mycobacterium bovis, shares 99.9% of genomic identity with M. tuberculosis, M. africanum and M. microti. Within this 0.1 % of difference, there are two genetic regions characteristics of M. bovis that are deleted in M. tuberculo­sis H37Rv: RvD1 and RvD2. According to bioinformatic analysis, these regions contain Open Reading Frames (ORFs. With the purpose of determining if the RvD1 region transcribes the ORFs predicted by bioinformatics (ORF1, ORF2 and Rv2024; total RNA was extracted from a culture of M. bovis BCG Pasteur, at different time points along the growth curve. The RNA samples were analyzed by Real Time Reverse Transcription - Poly-merase Chain Reaction (RTq-PCR. The findings show that ORF1, ORF2 and Rv2024, were transcribed consti-tutively, something that has not been reported previously. These results are a first step in order to determine the function of M. bovis RvD1 region, its possible role in pathogenesis and its interaction with both cattle and humans. Key words: Mycobacterium bovis, BCG, RNA, Real Time, RT-PCR, RvD1

  10. Decay of Mycobacterium bovis in whole milk submitted to pasteurization parameters

    Directory of Open Access Journals (Sweden)

    Leandro Ribeiro

    2016-11-01

    Full Text Available Parameters for milk pasteurization were established a long time ago, considering the thermal resistance of Mycobacterium bovis, and the systematic adoption of this process has drastically reduced the incidence of human tuberculosis caused by this pathogen. However, more recently, molecular methods have allowed the identification of genetic variations in this bacterium that may lead to greater thermal resistance. The aim of this study was to investigate whether genetic variation leads to variation in the death pattern of this bacterium during the milk pasteurization process. Samples of UHT (ultra-high temperature-treated whole milk were artificially contaminated with four different Mycobacterium bovis spoligotypes and were subjected to pasteurization by low-temperature long-time (LTLT and high-temperature short-time (HTST treatments. The M. bovis spoligotypes were quantified (Colony Forming Unit per milliliter of milk before and during the thermal process. The decay of the pathogen was quantified by calculating the difference between the measurements at the beginning and at the end of the thermal treatment. The data demonstrated that the LTLT and HTST pasteurization processes considerably reduced the M. bovis load in the milk; however, the bacterium was not eliminated. There was no difference in the thermal resistance of the spoligotypes tested or in the efficiency of pasteurization processes (LTLT versus HTST. However, heating phase was more effective in reducing the M. bovis load than the target temperature maintenance phase.

  11. A space-time analysis of Mycoplasma bovis: bulk tank milk antibody screening results from all Danish dairy herds in 2013-2014

    DEFF Research Database (Denmark)

    Arede, Margarida; Nielsen, Per Kantsø; Ahmed, Syed Sayeem Uddin

    2016-01-01

    Mycoplasma bovis is an important pathogen causing severe disease outbreaks in cattle farms. Since 2011, there has been an apparent increase in M. bovis outbreaks among Danish dairy cattle herds. The dairy cattle industry performed cross-sectional antibody screening for M. bovis on four occasions,...

  12. Calculus Instructors' and Students' Discourses on the Derivative

    Science.gov (United States)

    Park, Jungeun

    2011-01-01

    Recently, there has been an increasing interest in collegiate mathematics education, especially teaching and learning calculus (e.g., Oehrtman, Carlson, & Thompson, 2008; Speer, Smith, & Horvath, 2010). Of many calculus concepts, the derivative is known as a difficult concept for students to understand because it involves various concepts…

  13. Restricted diversity of dental calculus methanogens over five centuries, France.

    Science.gov (United States)

    Huynh, Hong T T; Nkamga, Vanessa D; Signoli, Michel; Tzortzis, Stéfan; Pinguet, Romuald; Audoly, Gilles; Aboudharam, Gérard; Drancourt, Michel

    2016-05-11

    Methanogens are acknowledged archaeal members of modern dental calculus microbiota and dental pathogen complexes. Their repertoire in ancient dental calculus is poorly known. We therefore investigated archaea in one hundred dental calculus specimens collected from individuals recovered from six archaeological sites in France dated from the 14(th) to 19(th) centuries AD. Dental calculus was demonstrated by macroscopic and cone-beam observations. In 56 calculus specimens free of PCR inhibition, PCR sequencing identified Candidatus Methanobrevibacter sp. N13 in 44.6%, Methanobrevibacter oralis in 19.6%, a new Methanomassiliicoccus luminyensis-like methanogen in 12.5%, a Candidatus Nitrososphaera evergladensis-like in one and Methanoculleus bourgensis in one specimen, respectively. One Candidatus Methanobrevibacter sp. N13 dental calculus was further documented by fluorescent in situ hybridization. The prevalence of dental calculus M. oralis was significantly lower in past populations than in modern populations (P = 0.03, Chi-square test). This investigation revealed a previously unknown repertoire of archaea found in the oral cavity of past French populations as reflected in preserved dental calculus.

  14. Dental calculus formation in children and adolescents undergoing hemodialysis.

    Science.gov (United States)

    Martins, Carla; Siqueira, Walter Luiz; Oliveira, Elizabeth; Nicolau, José; Primo, Laura Guimarães

    2012-10-01

    This study aimed to determine whether dental calculus formation is really higher among patients with chronic kidney disease undergoing hemodialysis than among controls. Furthermore, the study evaluated correlations between dental calculus formation and dental plaque, variables that are related to renal disease and/or saliva composition. The Renal Group was composed of 30 patients undergoing hemodialysis, whereas the Healthy Group had 30 clinically healthy patients. Stimulated whole saliva and parotid saliva were collected. Salivary flow rate and calcium and phosphate concentrations were determined. In the Renal Group the saliva collection was carried out before and after a hemodialysis session. Patients from both groups received intraoral exams, oral hygiene instructions, and dental scaling. Three months later, the dental calculus was measured by the Volpe-Manhold method to determine the rate of dental calculus formation. The Renal Group presented a higher rate of dental calculus formation (p dental calculus formation and whole saliva flow rate in the Renal Group after a hemodialysis session (r = 0.44, p dental calculus was associated with phosphate concentration in whole saliva from the Renal Group (p dental calculus formation, probably due to salivary variables.

  15. Covariant differential calculus on quantum spheres of odd dimension

    International Nuclear Information System (INIS)

    Welk, M.

    1998-01-01

    Covariant differential calculus on the quantum spheres S q 2N-1 is studied. Two classification results for covariant first order differential calculi are proved. As an important step towards a description of the noncommutative geometry of the quantum spheres, a framework of covariant differential calculus is established, including first and higher order calculi and a symmetry concept. (author)

  16. Towards Model Checking a Spi-Calculus Dialect

    NARCIS (Netherlands)

    Gnesi, S.; Latella, D.; Lenzini, Gabriele

    We present a model checking framework for a spi-calculus dialect which uses a linear time temporal logic for expressing security properties. We have provided our spi-calculus dialect, called SPID, with a semantics based on labeled transition systems (LTS), where the intruder is modeled in the

  17. Secure Data Flow in a Calculus for Context Awareness

    DEFF Research Database (Denmark)

    Bucur, Doina; Nielsen, Mogens

    2008-01-01

    We present a Mobile-Ambients-based process calculus to describe context-aware computing in an infrastructure-based Ubiquitous Computing setting. In our calculus, computing agents can provide and discover contextual information and are owners of security policies. Simple access control to contextual...

  18. Utilizing Microsoft Mathematics in Teaching and Learning Calculus

    Science.gov (United States)

    Oktaviyanthi, Rina; Supriani, Yani

    2015-01-01

    The experimental design was conducted to investigate the use of Microsoft Mathematics, free software made by Microsoft Corporation, in teaching and learning Calculus. This paper reports results from experimental study details on implementation of Microsoft Mathematics in Calculus, students' achievement and the effects of the use of Microsoft…

  19. Equality and fixpoints in the calculus of structures

    DEFF Research Database (Denmark)

    Chaudhuri, Kaustuv; Guenot, Nicolas

    2014-01-01

    The standard proof theory for logics with equality and fixpoints suffers from limitations of the sequent calculus, where reasoning is separated from computational tasks such as unification or rewriting. We propose in this paper an extension of the calculus of structures, a deep inference formalism...

  20. Reflections on Our First Calculus Undergraduate Teaching Assistant

    Science.gov (United States)

    Deshler, Jessica M.

    2016-01-01

    This article describes some reflections from the first Calculus I undergraduate teaching assistant in our department as she explored the various ways in which she was able to support both novice and experienced Calculus teachers and the effect of her experience on her academic and career plans.

  1. Effects of Clicker Use on Calculus Students' Mathematics Anxiety

    Science.gov (United States)

    Batchelor, John

    2015-01-01

    This paper reports the results of a survey study of clicker use and mathematics anxiety among students enrolled in an undergraduate calculus course during the Fall 2013 semester. Students in two large lecture sections of calculus completed surveys at the beginning and end of the course. One class used clickers, whereas the other class was taught…

  2. Coordinating Multiple Representations in a Reform Calculus Textbook

    Science.gov (United States)

    Chang, Briana L.; Cromley, Jennifer G.; Tran, Nhi

    2016-01-01

    Coordination of multiple representations (CMR) is widely recognized as a critical skill in mathematics and is frequently demanded in reform calculus textbooks. However, little is known about the prevalence of coordination tasks in such textbooks. We coded 707 instances of CMR in a widely used reform calculus textbook and analyzed the distributions…

  3. A Calculus of Circular Proofs and its Categorical Semantics

    DEFF Research Database (Denmark)

    Santocanale, Luigi

    2002-01-01

    We present a calculus of “circular proofs”: the graph underlying a proof is not a finite tree but instead it is allowed to contain a certain amount of cycles.The main challenge in developing a theory for the calculus is to define the semantics of proofs, since the usual method by induction...

  4. On Flipping the Classroom in Large First Year Calculus Courses

    Science.gov (United States)

    Jungic, Veselin; Kaur, Harpreet; Mulholland, Jamie; Xin, Cindy

    2015-01-01

    Over the course of two years, 2012-2014, we have implemented a "flipping" the classroom approach in three of our large enrolment first year calculus courses: differential and integral calculus for scientists and engineers. In this article we describe the details of our particular approach and share with the reader some experiences of…

  5. Modelling the Landing of a Plane in a Calculus Lab

    Science.gov (United States)

    Morante, Antonio; Vallejo, Jose A.

    2012-01-01

    We exhibit a simple model of a plane landing that involves only basic concepts of differential calculus, so it is suitable for a first-year calculus lab. We use the computer algebra system Maxima and the interactive geometry software GeoGebra to do the computations and graphics. (Contains 5 figures and 1 note.)

  6. Type Inference for Session Types in the Pi-Calculus

    DEFF Research Database (Denmark)

    Graversen, Eva Fajstrup; Harbo, Jacob Buchreitz; Huttel, Hans

    2014-01-01

    In this paper we present a direct algorithm for session type inference for the π-calculus. Type inference for session types has previously been achieved by either imposing limitations and restriction on the π-calculus, or by reducing the type inference problem to that for linear types. Our approach...

  7. Evaluating the Use of Learning Objects for Improving Calculus Readiness

    Science.gov (United States)

    Kay, Robin; Kletskin, Ilona

    2010-01-01

    Pre-calculus concepts such as working with functions and solving equations are essential for students to explore limits, rates of change, and integrals. Yet many students have a weak understanding of these key concepts which impedes performance in their first year university Calculus course. A series of online learning objects was developed to…

  8. Partial Fractions in Calculus, Number Theory, and Algebra

    Science.gov (United States)

    Yackel, C. A.; Denny, J. K.

    2007-01-01

    This paper explores the development of the method of partial fraction decomposition from elementary number theory through calculus to its abstraction in modern algebra. This unusual perspective makes the topic accessible and relevant to readers from high school through seasoned calculus instructors.

  9. On the Expressive Power of Polyadic Synchronisation in π- calculus

    DEFF Research Database (Denmark)

    Carbone, Marco; Maffeis, Sergio

    2002-01-01

    We extend the pi-calculus with polyadic synchronisation, a generalisation of the communication mechanism which allows channel names to be composite. We show that this operator embeds nicely in the theory of pi-calculus, we suggest that it permits divergence-free encodings of distributed calculi, ...

  10. Giant urinary bladder calculus: Case report | Otieno | East African ...

    African Journals Online (AJOL)

    A vertical calculus weighing more than 100 g is categorised as a giant urinary bladder stone. Giant urinary bladder stones are very rare and very few cases have been reported in English literature and only one case from Africa. This is a case report of a patient with a giant urinary bladder calculus presenting as a rectal ...

  11. Prostatic fossa calculus | El Abiad | Pan African Medical Journal

    African Journals Online (AJOL)

    As part of the evaluation, a plain radiograph was performed and incidentally showed a radiopaque prostatic calculus (Red arrows). A retrograde urethrocystography, performed after a 10-days course of antibiotics, confirmed the presence of an approximately 35 mm non-obstructive calculus occupying almost the whole ...

  12. A Calculus of Circular Proofs and its Categorical Semantics

    DEFF Research Database (Denmark)

    Santocanale, Luigi

    2002-01-01

    We present a calculus of "circular proofs": the graph underlying a proof is not a finite tree but instead it is allowed to contain a certain amount of cycles.The main challenge in developing a theory for the calculus is to define the semantics of proofs, since the usual method by induction...

  13. Calculus in High School--At What Cost?

    Science.gov (United States)

    Sorge, D. H.; Wheatley, G. H.

    1977-01-01

    Evidence on the decline in preparation of entering calculus students and the relationship to high school preparation is presented, focusing on the trend toward the de-emphasis of trigonometry and analytic geometry in favor of calculus. Data on students' perception of the adequacy of their preparation are also presented. (Author/MN)

  14. Advanced Placement Mathematics Calculus, Grade 12 Curriculum Guide.

    Science.gov (United States)

    Scharf, John; And Others

    This document is a guide to the advanced placement program in calculus for grade 12 in the city schools in Warren, Ohio. The program covers analytic geometry, differential and integral calculus of algebraic functions, elementary transcendental functions, and applications of differentiation and integration. The philosophy and aims of the program…

  15. DIFFERENTIAL AND INTEGRAL CALCULUS. A TENTATIVE CURRICULUM GUIDE.

    Science.gov (United States)

    BRANT, VINCENT; GERARDI, WILLIAM

    A GUIDE FOR A 1-YEAR COURSE IN DIFFERENTIAL AND INTEGRAL CALCULUS PREREQUISITED KNOWLEDGE IN ALGEBRA, ANALYTIC TRIGONOMETRY, AND ELEMENTARY ANALYSIS. EACH ASSIGNMENT CONTAINED BOTH NEW AND REVIEW WORK TO REINFORCE THE NEW WORK. THERE WERE ELEVEN UNITS OF STUDY USING THE FOLLOWING FOUR BOOKS--"CALCULUS AND ANALYTIC GEOMETRY, THIRD…

  16. Calculus: A Computer Oriented Presentation, Part 1 [and] Part 2.

    Science.gov (United States)

    Stenberg, Warren; Walker, Robert J.

    Parts one and two of a one-year computer-oriented calculus course (without analytic geometry) are presented. The ideas of calculus are introduced and motivated through computer (i.e., algorithmic) concepts. An introduction to computing via algorithms and a simple flow chart language allows the book to be self-contained, except that material on…

  17. Visual Thinking and Gender Differences in High School Calculus

    Science.gov (United States)

    Haciomeroglu, Erhan Selcuk; Chicken, Eric

    2012-01-01

    This study sought to examine calculus students' mathematical performances and preferences for visual or analytic thinking regarding derivative and antiderivative tasks presented graphically. It extends previous studies by investigating factors mediating calculus students' mathematical performances and their preferred modes of thinking. Data were…

  18. Descartes' Calculus of Subnormals: What Might Have Been

    Science.gov (United States)

    Boudreaux, Gregory Mark; Walls, Jess E.

    2013-01-01

    Rene Descartes' method for finding tangents (equivalently, subnormals) depends on geometric and algebraic properties of a family of circles intersecting a given curve. It can be generalized to establish a calculus of subnormals, an alternative to the calculus of Newton and Leibniz. Here we prove subnormal counterparts of the well-known…

  19. On flipping the classroom in large first year calculus courses

    Science.gov (United States)

    Jungić, Veselin; Kaur, Harpreet; Mulholland, Jamie; Xin, Cindy

    2015-05-01

    Over the course of two years, 2012--2014, we have implemented a 'flipping' the classroom approach in three of our large enrolment first year calculus courses: differential and integral calculus for scientists and engineers. In this article we describe the details of our particular approach and share with the reader some experiences of both instructors and students.

  20. Extending the Extensional Lambda Calculus with Surjective Pairing is Conservative

    DEFF Research Database (Denmark)

    Støvring, Kristian

    2006-01-01

    We answer Klop and de Vrijer's question whether adding surjective-pairing axioms to the extensional lambda calculus yields a conservative extension. The answer is positive. As a byproduct we obtain a "syntactic" proof that the extensional lambda calculus with surjective pairing is consistent....

  1. A compositional proof system for the modal μ-calculus

    DEFF Research Database (Denmark)

    Andersen, Henrik Reif; Stirling, C.; Winskel,, G.

    1994-01-01

    We present a proof system for determining satisfaction between processes in a fairly general process algebra and assertions of the modal μ-calculus. The proof system is compositional in the structure of processes. It extends earlier work on compositional reasoning within the modal μ-calculus and ...

  2. Experimental Design: Utilizing Microsoft Mathematics in Teaching and Learning Calculus

    Science.gov (United States)

    Oktaviyanthi, Rina; Supriani, Yani

    2015-01-01

    The experimental design was conducted to investigate the use of Microsoft Mathematics, free software made by Microsoft Corporation, in teaching and learning Calculus. This paper reports results from experimental study details on implementation of Microsoft Mathematics in Calculus, students' achievement and the effects of the use of Microsoft…

  3. Differential calculus on quantized simple Lie groups

    Energy Technology Data Exchange (ETDEWEB)

    Jurco, B. (Dept. of Optics, Palacky Univ., Olomouc (Czechoslovakia))

    1991-07-01

    Differential calculi, generalizations of Woronowicz's four-dimensional calculus on SU{sub q}(2), are introduced for quantized classical simple Lie groups in a constructive way. For this purpose, the approach of Faddeev and his collaborators to quantum groups was used. An equivalence of Woronowicz's enveloping algebra generated by the dual space to the left-invariant differential forms and the corresponding quantized universal enveloping algebra, is obtained for our differential calculi. Real forms for q {epsilon} R are also discussed. (orig.).

  4. A robust interpretation of duration calculus

    DEFF Research Database (Denmark)

    Franzle, M.; Hansen, Michael Reichhardt

    2005-01-01

    We transfer the concept of robust interpretation from arithmetic first-order theories to metric-time temporal logics. The idea is that the interpretation of a formula is robust iff its truth value does not change under small variation of the constants in the formula. Exemplifying this on Duration...... Calculus (DC), our findings are that the robust interpretation of DC is equivalent to a multi-valued interpretation that uses the real numbers as semantic domain and assigns Lipschitz-continuous interpretations to all operators of DC. Furthermore, this continuity permits approximation between discrete...

  5. Regge calculus and observations. II. Further applications

    International Nuclear Information System (INIS)

    Williams, R.M.; Ellis, G.F.R.

    1983-03-01

    The method, developed in an earlier paper, for tracing geodesics of particles and light rays through Regge calculus space-times, is applied to a number of problems in the Schwarschild geometry. It is possible to obtain accurate predictions of light-bending by taking sufficiently small Regge blocks. Calculations of perihelion precession, Thomas precession and the distortion of a ball of fluid moving on a geodesic can also show good agreement with the analytic solution. However difficulties arise in obtaining accurate predictions for general orbits in these space-times. Applications to other problems in general relativity are discussed briefly. (author)

  6. Regge calculus and observations. II. Further applications.

    Science.gov (United States)

    Williams, Ruth M.; Ellis, G. F. R.

    1984-11-01

    The method, developed in an earlier paper, for tracing geodesies of particles and light rays through Regge calculus space-times, is applied to a number of problems in the Schwarzschild geometry. It is possible to obtain accurate predictions of light bending by taking sufficiently small Regge blocks. Calculations of perihelion precession, Thomas precession, and the distortion of a ball of fluid moving on a geodesic can also show good agreement with the analytic solution. However difficulties arise in obtaining accurate predictions for general orbits in these space-times. Applications to other problems in general relativity are discussed briefly.

  7. Giant Submandibular Calculus Eroding Oral Cavity Mucosa.

    Science.gov (United States)

    Lim, Eng Haw; Nadarajah, Sanjeevan; Mohamad, Irfan

    2017-09-01

    Sialolithiasis is the formation of calculi or sialoliths in the salivary gland. It is the most common benign condition of the salivary gland. Sialolithiasis can occur in all salivary glands. The submandibular gland is most commonly affected followed by the parotid gland. Calculi commonly measure less than 10 mm. Calculi of more than 15 mm are termed giant salivary gland calculi and are infrequently reported in the literature. Here, we report a case of unusually large submandibular gland calculus of 5 cm in greatest dimension which caused erosion of the oral cavity.

  8. On d=2 Regge calculus without triangulation

    International Nuclear Information System (INIS)

    Foerster, D.

    1987-01-01

    The supersymmetric version of a previously developed Regge calculus for d=2 euclidean gravity is given. In the context of string theory, a continuum theory is likely to exist for D<2 external space-time dimensions, just like in the bosonic case and essentially in agreement with the weak coupling regime D≤1 found by Gervais and Neveu for Liouville theory and its supersymmetric extension. The techniques developed here are intended to be of use, eventually, in lowering the critical dimensions of string theories. (orig.)

  9. Covariant super reggeon calculus for superstrings

    International Nuclear Information System (INIS)

    Petersen, J.L.; Sidenius, J.R.; Tollsten, A.K.

    1988-07-01

    A previously developed formalism for the bosonic string is extended to the Neveu-Schwarz-Ramond string using 2-d superspace techniques throughout. 3-string vertices for NS- and R-strings are constructed, sewing rules developed, and the technique of quasi-superconformal modes is set up for constructing the measure on super moduli space. Symmetries, such as superconformal invariance and BRST-invariance, are guaranteed ab initio. Picture changing and bosonization are avoided. Examples are given. The formalism should allow a superstring loop calculus based on supermoduli. Results concerning the ensuing super-Schottky description are given. (orig.)

  10. An introduction to the calculus of variations

    CERN Document Server

    Pars, LA

    2009-01-01

    This clear, rigorous introduction to the calculus of variations covers applications to geometry, dynamics, and physics. Focusing upon problems with one independent variable, the text connects the abstract theory to its use in concrete problems. It offers a working knowledge of relevant techniques, plus an impetus for further study.Starting with an overview of fundamental problems and theories, the text advances to illustrative examples and examinations of variable end-points and the fundamental sufficiency theorem. Subsequent chapters explore the isoperimetrical problem, curves in space, the p

  11. The prevalence of Mycobacterium bovis-infection and atypical mycobacterioses in cattle in and around Morogoro, Tanzania

    DEFF Research Database (Denmark)

    Durnez, Lies; Sadiki, Harrison; Katakweba, Abdul

    2009-01-01

     A study was conducted to determine the prevalence of Mycobacterium bovis-infection and atypical mycobacterioses in different cattle herd management systems in and around Morogoro, Tanzania. Between April and June 2005, a total of 728 bovines from 49 herds were tested for M. bovis-infection and a...

  12. Composition and immunoreactivity of the A60 complex and other cell fractions from Mycobacterium bovis BCG.

    Science.gov (United States)

    Cocito, C; Vanlinden, F

    1995-02-01

    Surface static cultures of Mycobacterium bovis BCG contained cells embedded in an extracellular matrix, whose mechanical removal yielded free cells that were pressure disrupted and fractionated into cytoplasm and walls. Cell envelopes were either mechanically disrupted or extracted with detergents. Intracellular and extracellular fractions were analysed for proteins, polysaccharides, and antigen 6O (A60), a major complex immunodominant in tuberculosis. A60 was present in extracellular matrix, cytoplasm and walls: it represented a substantial portion of the proteins and polysaccharides of these fractions. While the protein/polysaccharide ratio varied according to the origin of A60 preparations, the electrophoretic patterns of A60 proteins (which accounted for the immunogenicity of the complex) remained unchanged. Western blots pointed to the proteins present within the 29-45 kDa range as the A60 components endowed with the highest immunogenicity level. Since the most heavily stained protein bands in SDS-PAGE patterns were located outside the region best recognized by antisera, a striking discordance was found between concentration and immunogenicity patterns of A60 proteins. The electrophoretic patterns of A60- and non-A60-proteins from cytoplasm were also different. A60 complexes in dot blots and some electrophoresed A60 proteins reacted with monoclonal antibodies directed against lipoarabinomannan (LAM), a highly immunogenic polymer of cell envelope. This contaminating compound was removed from A60 with organic solvents and detergents. SDS-PAGE and Western blot patterns of proteins from delipidated A60 were similar to those of native A60 proteins.

  13. Calculus detection technologies: where do we stand now?

    Science.gov (United States)

    Archana, V

    2014-01-01

    Epidemiological studies have implicated dental calculus as an ideal substrate for subgingival microbial colonization. Therefore, the main objective of periodontal therapy is to eliminate the microbial biofilm along with the calculus deposits from the root surface by root surface debridement. Over the past years, a large number of clinical and laboratory studies have been conducted to evaluate the efficacy of calculus removal by various methods. None of these conventional methods or devices was effective in completely eliminating all the calculus from the diseased root surfaces. In this context, a number of newer technologies have been developed to identify and selectively remove the dental calculus. Regarding this fact, the present article highlights a critical review of these devices based on published clinical and experimental data.

  14. The ZX-calculus is complete for stabilizer quantum mechanics

    International Nuclear Information System (INIS)

    Backens, Miriam

    2014-01-01

    The ZX-calculus is a graphical calculus for reasoning about quantum systems and processes. It is known to be universal for pure state qubit quantum mechanics (QM), meaning any pure state, unitary operation and post-selected pure projective measurement can be expressed in the ZX-calculus. The calculus is also sound, i.e. any equality that can be derived graphically can also be derived using matrix mechanics. Here, we show that the ZX-calculus is complete for pure qubit stabilizer QM, meaning any equality that can be derived using matrices can also be derived pictorially. The proof relies on bringing diagrams into a normal form based on graph states and local Clifford operations. (paper)

  15. Calculus detection technologies: where do we stand now?

    Science.gov (United States)

    Archana, V

    2014-01-01

    Epidemiological studies have implicated dental calculus as an ideal substrate for subgingival microbial colonization. Therefore, the main objective of periodontal therapy is to eliminate the microbial biofilm along with the calculus deposits from the root surface by root surface debridement. Over the past years, a large number of clinical and laboratory studies have been conducted to evaluate the efficacy of calculus removal by various methods. None of these conventional methods or devices was effective in completely eliminating all the calculus from the diseased root surfaces. In this context, a number of newer technologies have been developed to identify and selectively remove the dental calculus. Regarding this fact, the present article highlights a critical review of these devices based on published clinical and experimental data. PMID:25870667

  16. Intitialization, Conceptualization, and Application in the Generalized Fractional Calculus

    Science.gov (United States)

    Lorenzo, Carl F.; Hartley, Tom T.

    1998-01-01

    This paper provides a formalized basis for initialization in the fractional calculus. The intent is to make the fractional calculus readily accessible to engineering and the sciences. A modified set of definitions for the fractional calculus is provided which formally include the effects of initialization. Conceptualizations of fractional derivatives and integrals are shown. Physical examples of the basic elements from electronics are presented along with examples from dynamics, material science, viscoelasticity, filtering, instrumentation, and electrochemistry to indicate the broad application of the theory and to demonstrate the use of the mathematics. The fundamental criteria for a generalized calculus established by Ross (1974) are shown to hold for the generalized fractional calculus under appropriate conditions. A new generalized form for the Laplace transform of the generalized differintegral is derived. The concept of a variable structure (order) differintegral is presented along with initial efforts toward meaningful definitions.

  17. Initialization, conceptualization, and application in the generalized (fractional) calculus.

    Science.gov (United States)

    Lorenzo, Carl F; Hartley, Tom T

    2007-01-01

    This paper provides a formalized basis for initialization in the fractional calculus. The intent is to make the fractional calculus readily accessible to engineering and the sciences. A modified set of definitions for the fractional calculus is provided which formally include the effects of initialization. Conceptualizations of fractional derivatives and integrals are shown. Physical examples of the basic elements from electronics are presented along with examples from dynamics, material science, viscoelasticity, filtering, instrumentation, and electrochemistry to indicate the broad application of the theory and to demonstrate the use of the mathematics. The fundamental criteria for a generalized calculus established by Ross (1974) are shown to hold for the generalized fractional calculus under appropriate conditions. A new generalized form for the Laplace transform of the generalized differintegral is derived. The concept of a variable structure (order) differintegral is presented along with initial efforts toward meaningful definitions.

  18. Understanding Calculus beyond Computations: A Descriptive Study of the Parallel Meanings and Expectations of Teachers and Users of Calculus

    Science.gov (United States)

    Ferguson, Leann J.

    2012-01-01

    Calculus is an important tool for building mathematical models of the world around us and is thus used in a variety of disciplines, such as physics and engineering. These disciplines rely on calculus courses to provide the mathematical foundation needed for success in their courses. Unfortunately, due to the basal conceptions of what it means to…

  19. [Evaluation of variable number of tandem repeats (VNTR) isolates of Mycobacterium bovis in Algeria].

    Science.gov (United States)

    Sahraoui, Naima; Muller, Borna; Djamel, Yala; Fadéla, Boulahbal; Rachid, Ouzrout; Jakob, Zinsstag; Djamel, Guetarni

    2010-01-01

    The discriminatory potency of variable number of tandem repeats (VNTR), based on 7 loci (MIRU 26, 27 and 5 ETRs A, B, C, D, E) was assayed on Mycobacterium bovis strains obtained from samples due to tuberculosis in two slaughterhouses in Algeria. The technique of MIRU-VNTR has been evaluated on 88 strains of M. bovis and one strain of M. caprea and shows 41 different profiles. Results showed that the VNTR were highly discriminatory with an allelic diversity of 0.930 when four loci (ETR A, B, C and MIRU 27) were highly discriminatory (h>0.25) and three loci (ETR D and E MIRU 26) moderately discriminatory (0.11VNTR loci were highly discriminatory be adequate for the first proper differentiation of strains of M. bovis in Algeria. The VNTR technique has proved a valuable tool for further development and application of epidemiological research for the of tuberculosis transmission in Algeria.

  20. Successful vaccination against Boophilus microplus and Babesia bovis using recombinat antigens

    Directory of Open Access Journals (Sweden)

    P. Willadsen

    1992-01-01

    Full Text Available Current methods for the control of the cattle tick Boophils microplus and the agent of bovine babesiosis, Babesia bovis are unsatisfactory. Effective immunological control of both parasites would have great advantages. However, naturally acquired immunity to the tick is generally unable to prevent serious production losses. A vaccine against the tick, based on a novel form of immunization, is being developed. A protective antigen has been isolated from the tick, characterized and produced as an effective, recombinant protein. A vaccine incorporating this antigen is currently undergoing field trials. In the Australian situation, improved tick control will probably increase endemic instability with respect to B. bovis. Fortunately, a trivalent, recombinant B. bovis vaccine has also been developed. This too is now undergoing pre-registration field trials.