WorldWideScience

Sample records for caged ball-valve prosthesis

  1. Extended Durability of a Cloth-Covered Star-Edwards Caged Ball Prosthesis in Aortic Position

    Directory of Open Access Journals (Sweden)

    Yusuf Ata

    2009-01-01

    Full Text Available The Starr-Edwards caged ball valve is one of the oldest cardiac valve prosthesis and was widely used all around the world in the past decades. Despite the long-term results that have been reported there are only a few cases reported that exceed 30 years of durability. Here in, we report a 53-year-old patient with a well-functioning 35-year-old aortic Starr-Edwards caged ball prosthesis.

  2. Left atrial ball valve thrombus

    Directory of Open Access Journals (Sweden)

    R. Balaji

    2013-10-01

    Full Text Available "Ball valve thrombus" which is a spherical free floating clot in left atrium is an often quoted, but uncommonly encountered complication in patients with severe mitral stenosis of rheumatic origin, who are in atrial fibrillation. We describe the case of a 31-year-old lady with rheumatic heart disease, severe mitral stenosis and moderately severe aortic stenosis who had undergone closed mitral valvotomy 13 years ago. The patient presented with an episode of non-exertional syncope and breathlessness on exertion of 6 months duration and was in normal sinus rhythm. Echocardiography facilitated ante-mortem diagnosis and prompt institution of surgery was life saving.

  3. Segmented ball valve is easy to open and close

    Science.gov (United States)

    Prono, E.; Shinault, L. H.; Speisman, C.

    1966-01-01

    Segmented ball valve and flowmeter in the same spherical housing provide a valve that will handle large fluid volume without bulkiness and weight of blade valves or conventional ball valves. The valve is easily opened or closed and the flowmeter remains stationary, so errors are eliminated.

  4. Design factors for “linear” ball valve: theoretical and experimental studies

    OpenAIRE

    Thananchai Leephakpreeda

    2005-01-01

    Generic non-linear flow characteristics of the conventional ball valve limit the applications of flow modulation in fluid processes. This work presents the flow characteristics of fluid flowing through the conventional and modified ball valves for feasibility of a “linear” ball valve. Theoretical studies are discussed for determining explicit and implicit factors on the valve coefficient, which modulates the flow rate of fluid when the ball valve is operated in flow control processes. In expe...

  5. Whitey SCHe Ball Valves Provide Test Port Isolation

    Energy Technology Data Exchange (ETDEWEB)

    MISKA, C.R.

    2000-09-15

    These valves are 1/4 inch ball valves fabricated of 316 stainless steel. Packing is TFE (standard). They are used as normally closed isolation valves for test ports in the SCHe System between the gage root valve and the pressure indicator.

  6. Space Shuttle Orbital Maneuvering Subsystem (OMS) Engine Propellant Leakage Ball-Valve Shaft Seals

    Science.gov (United States)

    Lueders, Kathy; Buntain, Nick; Fries, Joseph (Technical Monitor)

    1999-01-01

    Evidence of propellant leakage across ball-valve shaft seals has been noted during the disassembly of five flight engines and one test engine at the NASA Lyndon B. Johnson Space Center, White Sands Test Facility. Based on data collected during the disassembly of these five engines, the consequences of propellant leakage across the ball-valve shaft seals can be divided into four primary areas of concern: Damage to the ball-valve pinion shafts, damage to sleeved bearings inside the ball-valve and actuator assemblies, degradation of the synthetic rubber o-rings used in the actuator assemblies, and corrosion and degradation to the interior of the actuator assemblies. The exact time at which leakage across the ball-valve shaft seals occurs has not been determined, however, the leakage most likely occurs during engine firings when, depending on the specification used, ball-valve cavity pressures range as high as 453 to 550 psia. This potential pressure range for the ball-valve cavities greatly exceeds the acceptance leakage test pressure of 332 psia. Since redesign and replacement of the ball-valve shaft seals is unlikely, the near term solution to prevent damage that occurs from shaft-seal leakage is to implement a routine overhaul and maintenance program for engines in the fleet. Recommended repair, verification, and possible preventative maintenance measures are discussed in the paper.

  7. Design factors for “linear” ball valve: theoretical and experimental studies

    Directory of Open Access Journals (Sweden)

    Thananchai Leephakpreeda

    2005-03-01

    Full Text Available Generic non-linear flow characteristics of the conventional ball valve limit the applications of flow modulation in fluid processes. This work presents the flow characteristics of fluid flowing through the conventional and modified ball valves for feasibility of a “linear” ball valve. Theoretical studies are discussed for determining explicit and implicit factors on the valve coefficient, which modulates the flow rate of fluid when the ball valve is operated in flow control processes. In experiment, the cross- sectional opening area at various opening degrees, the shape, and the location of the hole passage in valve ball are examined for complicated relations dependent to the flow rate of fluid. It can be concluded that those factors cause the modulation of flow rate when the ball is turned at different opening degree. In extended design of flow characteristics for linearity, they are to be taken into account.

  8. A magnetically actuated ball valve applicable for small-scale fluid flows

    DEFF Research Database (Denmark)

    Smistrup, Kristian; Stone, Howard A.

    2007-01-01

    We present three possible designs for magnetically actuated ball valves that can be scaled down to nanometer length scales. Analytical expressions are presented for the hydraulic resistance of the ball valve as a function of geometric parameters and the state of the valve, and we also present...... analytical expressions for the hydrodynamic force on the magnetic bead that functions as the ball in the valve. We verify these expressions numerically and calculate the magnetic forces that can be exerted on the magnetic bead using the proposed structures. Finally, for typical parameters we show...

  9. Whitey Swagelok SCHe Ball Valves Provide Isolation between SCHe Purge Lines C and D and the Process Vent

    Energy Technology Data Exchange (ETDEWEB)

    MISKA, C.R.

    2000-09-15

    These valves are 1/4 inch ball valves fabricated of 316 stainless steel. Packing is TFE (standard). They provide an isolation function betwen SCHe Purge Line C, (PV-V-*079), and Purge Line D, (PV-V-*080), and the Process Vent.

  10. Basaloid Squamous Cell Carcinoma: An Unusual Ball-Valve Laryngeal Obstruction

    Directory of Open Access Journals (Sweden)

    Sien Hui Tan

    2015-05-01

    Full Text Available Introduction: A rare case of basaloid squamous cell carcinoma (BSCC of the larynx, which has not been previously reported, is described. Case Report: A 60-year-old man was presented to the Otolaryngology Department with progressive dyspnoea and dysphagia to solids for over a period of 1 week. Direct laryngoscopy revealed a tumour at the laryngeal aspect of the epiglottis, which prolapsed into the laryngeal inlet each time the patient inspired. This resulted in an inspiratory stridor despite adequate glottic opening and normal mobility of the vocal cords.   Conclusion:  Therefore, in cases where a ball-valve lesion causes intermittent life-threatening airway obstruction, BSCC of the larynx, though rare, must be considered as a differential diagnosis.

  11. 3D flow numerical simulation of ball valve based on CFD%基于CFD的球阀三维流场数值模拟

    Institute of Scientific and Technical Information of China (English)

    张生昌; 张玉林; 方志明; 柯愈龙

    2013-01-01

    为了探索新型转子式油气混输泵出口球阀内流场规律,建立球阀流场的三维模型,利用Fluent软件,将标准k-ε湍流模型与多相流技术相结合,采用SIMPLE算法,对新型转子式油气混输泵出口球阀内的三维气液两相流场进行数值模拟.在容积含气率为25%,50%,75%的不同工况下,通过对球阀开启高度分别为3,5,7 mm时的速度场、压力场与气液相分布的分析,探讨在气液混输过程中阀的开启高度及不同气液比对阀内流场的影响规律.模拟结果表明:球阀开启高度越大,阀球上下压差越小;阀隙流速随着开启高度的增大而减小.在气液混输过程中气相介质主要靠近阀球壁流动,同一开启高度下气液比对阀隙流速的影响较小.研究结果直观展现了球阀内流场形态,在一定程度上揭示了气液两相介质在阀内的流动规律,为新型转子式油气混输泵出口球阀的设计与优化提供理论指导.%To explore the flow field law of the outlet ball valve of the new rotor oil-gas mixed pump, a 3D model of ball valve flow field was established. Using Fluent software, combining standard turbulent model and multiphase flow technology together, adopting SIMPLE algorithm, a 3D gas-liquid double-phase flow field in outlet ball valve of new rotor oil-gas mixed pump was numerically simulated. With gas fraction of 25% , 50% and 75% and valve's opening height at 3, 5 and 7 mm respectively, velocity field, pressure field and the distribution of liquid and gas was analyzed. The law of valve's opening height and different gas-liquid ratio's effect on outlet ball valves in the process of gas-liquid mixing was discussed. The simulation results show that, the greater the opening height, the smaller the pressure difference between ball valves: The gap flow velocity decreases as the open height increases. Gas mainly flows in the vicinity of the valve ball in the process of gas-liquid mixing. At the same

  12. 集输管道球阀的故障与维护%Faults and maintenance of ball valves in pipeline

    Institute of Scientific and Technical Information of China (English)

    余靓

    2015-01-01

    This paper presents the structure and working principles of pipeline ball valves along with faults diagnosis. Some maintenance and management technologies are put forward at the end.%本文阐述了管道球阀的组成结构以及工作原理,并对其使用过程中常见的故障进行分析,最后提出了几点球阀的维护和管理技术.

  13. 不锈钢球阀自动堆焊机的设计%Design of an Automatic Welding Machine for Stainless Steel Ball Valve

    Institute of Scientific and Technical Information of China (English)

    张辉; 冯晓宁

    2011-01-01

    This paper presents an automatic surface welding machine of welded stainless steel ball valve, mainly composed of the welding robot, welding machine and positioner. It automatically complete the surface welding of stainless steel layer of a complex space surface of the steel ball. After testing, the valve welding quality of stainless steel ball by the automatic surface welding machine meet the technical requirements.%设计了一种焊接不锈钢球阀的自动堆焊机,主要由焊接机器人、焊机及变位机组成, 能够直接在具有复杂空间表面的碳钢球体上自动地完成不锈钢层的堆焊.经过试验,自动堆焊机焊接的不锈钢球阀质量满足技术要求.

  14. Selection and Engineering on Fire Safe Shut Off Ball Valve%火灾安全型切断球阀的选型及相关设计

    Institute of Scientific and Technical Information of China (English)

    任振寰

    2011-01-01

    Control valve, as the terminal element of whole control loop, its security is always regarded as critical point. It's not enough that only focus on quality, accuracy and reliability of valve control, it should also pay attention to leakage of pipes and valves to avoid internal stream burning caused by outside fire source. Under this circumstance, concepts such as, fire safe, fire safe valve, fusible link etc. Are introduced sequently. The function of fire safe and Anti-static for fire safe soft sealing shut-off valve is specified, ball valve body selection as well as the method to improve fire safety level of ball valve are aslo presented, which is worth of reference.%控制阀作为最终执行元件,其安全性历来是关注的焦点.仅仅关注阀门调节品质,并考虑其准确性、可靠性是远远不够的,同时还要考虑管道及阀门等部件的泄漏问题,从而避免因为外部火灾而引起管道或设备内部物料的燃烧.在该前提下,Fire Safe,火灾安全型阀门,Fusible Link等概念被相继引入.针对火灾安全型软密封切断球阀,介绍了其火灾安全功能和防静电功能,以及球阀本体选择的注意事项,并探讨了提高球阀火灾安全性的方法,值得广大工程人员借鉴和参考.

  15. 高水头蝶阀与球阀的实用评析%Analysis on practicalities of high head butterfly valve and ball valve

    Institute of Scientific and Technical Information of China (English)

    罗洪

    2011-01-01

    针对有关工程的初步设计,进行了水轮机进水阀的应用研究.通过调查和数学计算,进行了高水头蝶阀与球阀的技术经济比较,并进行了相关论证分析.结果表明,在满足水轮机进水阀运行功能的前提下,在一定的水头范围内(如:250 m),水轮机进水阀采用高水头蝶阀最为经济,可以较大幅度地节约水轮机进水阀设备投资,从而提高设备的投资效益.%An applicable study on inlet valve of hydraulic turbine is made herein for the preliminary design of a relevant project Based on the investigation and mathematical calculation concerned, a tech-economic comparison is made between both the high-head butterfly valve and ball valve along with the related demonstration and analysis. The result shows that within a certain head range (I. E. 250 m), taking the high-head butterfly valve as the inlet valve for hydraulic turbine is most economical under the precondition of meeting the requirement of the operation function of the inlet valve for hydraulic turbine. In this way, not only the investment for the equipment of the hydraulic turbine inlet valve can be largely saved, but the investment efficiency of the equipment can also be enhanced.

  16. 抗硫球阀密封结构选材研究%Selection Research for Seat Sealing of Anti-Corrosion Ball Valve

    Institute of Scientific and Technical Information of China (English)

    张潇; 邓雄; 梁政; 王飞

    2012-01-01

    近年来,随着我国天然气工业的迅猛发展,涌现了一大批亟待开发的高含H2S气田.开展高含硫气田开发中的抗硫球阀密封结构的研究,解决目前抗硫球阀应用中,经常出现密封面腐蚀、泄露等问题,对确保高含硫气田开发地面系统的安全和平稳供气具有重要意义.以阀座密封面为研究对象,运用Pro/E对阀门密封件建模,并无缝连接到ANSYS中进行接触分析,分析不同阀座结构及材料的密封性能.研究结果显示:在材料屈服极限内,普通夹层阀座具有最大的连续接触压力,设计比压误差最小,为最优选型.%In recent years, with rapid development of China's natural gas industry,a large number of untapped high H2S gas field has sprung up.A nd it has great significance for ground system safety and stable supply and solving the problems of sealing surface corrosion, leaks and other issues of the ball valve in hydrogen sulfide environments.The research takes contact surface of valve seat as the research object, and analyzes the sealing performance among structures and mate rials.Using Pro/E to model the valve seal and seamlessly connect to ANSYS^br contacting analysis.Within the material yield limit,the results of the study show that the ordinary sandwich valve seat with the maximum continuous contact pressure and the minimum error under the designed specific pressure is the optimization model.

  17. A piezoelectrically actuated ball valve

    Science.gov (United States)

    Erwin, L. R.; Schwartz, H. W.; Teitelbaum, B. R.

    1972-01-01

    Bimorph strip composed of two layers of poled piezoelectric ceramic material closes and opens valve. Strip performs like capacitator, allowing initial inrush of current when valve is energized and then only small leakage current flows as valve remains energized.

  18. Bionic prosthesis

    OpenAIRE

    МЫЛЬНИКОВ А.М.

    2015-01-01

    The real achievement in the prosthetics has become artificial joints that function as well as natural joints. Bionic limbs are the most advanced type of prosthesis at the moment. These electronic devices are made from synthetic materials, but the person can manage them using his/her own nervous system through the targeted muscle reinnervation (recovery disturbed innervation of organs and tissues surgically).Principle of operation of bionic prosthesis. After the amputation because of a serious...

  19. The Application of Differential Flow Adjustable Shuttle Valve in the Control of Ball Valve%差流可调梭阀在球阀控制中的运用

    Institute of Scientific and Technical Information of China (English)

    曾祥炜; 高树藩; 许力宏; 丁会林

    2001-01-01

    The differential flow adjustable shuttle valve is an important and fundamental device to realize pipeline automation control. The paper introduces the working prrinciple and basical performance of the shuttle valve. The site test and application have shown that this valve is available not only in controlling and adjusting the on/off time of ball valve ,but also in that of butterfly valve ,gate valve and other valves ,as well as in adjusting the flow rate and pressure of main valve.%梭控球阀是实现管道自动化控制的一个重要基础元件,介绍了其工作原理和差流可调梭阀的基本特性。差流可调梭阀不仅适用于球阀,也适用于蝶阀、闸阀和其他阀启闭时间的控制与调节,同时还可对主阀体的流量和压力进行调节。

  20. 煤直接液化减压塔进料球阀失效分析及修复%Failure Analysis and Repair of Feedstock Ball Valve in Direct Coal Liquefaction Vacuum Tower

    Institute of Scientific and Technical Information of China (English)

    龙云飞; 龚宝龙

    2016-01-01

    介绍了煤直接液化工艺流程及其特点。根据减压塔进料球阀的工作参数和功能作用,比照其失效形貌,分析了该球阀发生磨损失效的原因,制定了相应的拆解和修复方案。对修复后的球阀进行检查和试验,以满足标准规范的要求。最后对该球阀的优化运行给出了建议。%The technological process and characteristics of the direct coal liquefaction are introduced. In consideration of the working parameters and functions as well as the failure morphology of the feedstock ball valve in the vacuum tower, the reason of the wear failure is analyzed and the corresponding disassembly and repair scheme are proposed. Then the examinations and tests are performed to meet the requirements of the standards. At last, the advices on the optimal operation are given.

  1. The aesthetic hand prosthesis.

    Science.gov (United States)

    Pillet, J

    1981-10-01

    The high-quality aesthetic prosthesis can be equally helpful to those with acquired amputation and to those whose loss is due to agenesis. Restoring near-normal appearance improves patients' function in a global sense, enabling them to better utilize what they have in the complex socioeconomic environment of today's mobile society. The aesthetic prosthesis often also gives some prehensile assistance, providing an opposition part for remaining digits or thumb. The needs of each patient must be carefully considered, and the prosthesis must conform to the high standards of quality outlined. Its use is primarily for the unilateral amputee who is making a good adjustment to the loss with realistic expectations.

  2. A fermionic spacetime cage

    CERN Document Server

    Lin, De-Hone

    2015-01-01

    This paper is concerned with the application of a spacetime structure to a three-dimensional quantum system. There are three components. First, the main part of this paper presents the constraint conditions which build the relation of a spacetime structure and a form invariance solution to the covariant Dirac equation. The second is to devise a spacetime cage for fermions with chosen constraints. The third part discusses the feasibility of the cage with an experiment.

  3. Stomatitis sub-prosthesis in patients with superior dental prosthesis

    Directory of Open Access Journals (Sweden)

    Antonia Martina Francisco Local

    2009-04-01

    Full Text Available Background: The stomatitis sub-prosthesis is one of the most frequent changes in hard palate mucous membrane in patients with mucous-supported dental prosthesis. It can be caused by multiple factors, which makes its study and prognosis more difficult. Objective: To describe the occurrence of stomatitis sub-prosthesis and its causes in patients with superior dental prosthesis. Method: Descriptive study including all the patients with superior dental prosthesis examined in the odontology consultation “Barrio Adentro” in the state of Miranda, Venezuela, from November, 2005 to March, 2006. The analysed variables were: age, sex, stomatitis level, teeth brushing frequency, prosthesis condition and use, palate mucous condition and frequency of odontology consultations. Results: 89 patients were attended, more 50% of them had superior dental prosthesis and presented stomatitis sub-prosthesis; the group between 35 and 59 years was the most affected, mainly females. Sub-prosthesis stomatitis type II was the most common and the main causes included constant use of the prosthesis and loose prosthesis. Buccal hygiene was not adequate in these patients. Most of them declared never attending to the dentist, or just when presenting some particular problem. Conclusion: Stomatitis prevalence was related with incorrect hygiene habits and lack of knowledge; it shows the importance of performing educative tasks to reduce this disease incidence.  

  4. Aesthetic finger prosthesis.

    Science.gov (United States)

    Shanmuganathan, N; Maheswari, M Uma; Anandkumar, V; Padmanabhan, T V; Swarup, Shailee; Jibran, Ahmed Hasan

    2011-12-01

    Complete or partial fingers are the most commonly encountered forms of partial hand losses. Though finger amputations are commonly due to traumatic injuries, digit loss may also be attributed to congenital malformations and disease. Irrespective of the etiology, the loss of a finger has a considerable functional and psychological impact on an individual. In order to alleviate these problems, partial or complete finger prosthesis may be fabricated. This clinical report portrays a method to fabricate silicone rubber prosthesis for a patient who has a partial finger loss caused due to trauma.

  5. Mobile Phone Faraday Cage

    CERN Document Server

    French, M M J

    2011-01-01

    A Faraday cage is an interesting physics phenomena where an electromagnetic wave can be excluded from a volume of space by enclosure with an electrically conducting material. The practical application of this in the classroom is to block the signal to a mobile phone by enclosing it in a metal can! The background of the physics behind this is described in some detail followed by a explanation of some demonstrations and experiments which I have used.

  6. Opinions on Ball Valve Participating in Regulation Guarantee When Pump-storaged Units Reject the Load%对抽水蓄能电站球阀参与机组甩负荷流量调节的几点看法

    Institute of Scientific and Technical Information of China (English)

    韩伶俐

    2013-01-01

    There are 4 sets of 300MW reversible storage units in a pumped storage power station. When the units reject the load, ball valves participate in adjusting of transient process. This article introduces calculation results of regulation guarantee provided by design institute and manufactory, and testing result of the units load-rejection at site, discusses the advantages and disadvantages on the ball valve’s participation in adjusting of transient process, and gives some advice.%  国内某抽水蓄能电站安装有4台单机容量为300MW的可逆式抽水蓄能机组,机组在发电工况甩负荷时球阀参与水力过渡过程调节。文章介绍了设计单位和制造厂商提供的机组调节保证计算成果,以及现场机组甩负荷试验结果,探讨了球阀参与机组甩负荷流量调节的利弊,并给出了建议。

  7. Aesthetic Finger Prosthesis

    OpenAIRE

    2011-01-01

    Complete or partial fingers are the most commonly encountered forms of partial hand losses. Though finger amputations are commonly due to traumatic injuries, digit loss may also be attributed to congenital malformations and disease. Irrespective of the etiology, the loss of a finger has a considerable functional and psychological impact on an individual. In order to alleviate these problems, partial or complete finger prosthesis may be fabricated. This clinical report portrays a method to fab...

  8. The stump and the prosthesis.

    Science.gov (United States)

    Day, H J

    1980-03-01

    In performing amputations the surgeon must bear in mind the biomechanical and other constraints of the prosthesis likely to be fitted and, so far as possible, should fashion the stump accordingly. The various types of prosthesis and their features are discussed in relation to amputations of the lower and upper limbs at all levels.

  9. Cryogenic Caging for Science Instrumentation

    Science.gov (United States)

    Penanen, Konstantin; Chui, Talso C.

    2011-01-01

    A method has been developed for caging science instrumentation to protect from pyro-shock and EDL (entry, descent, and landing) acceleration damage. Caging can be achieved by immersing the instrument (or its critical parts) in a liquid and solidifying the liquid by cooling. After the launch shock and/or after the payload has landed, the solid is heated up and evaporated.

  10. Faraday Cage Protects Against Lightning

    Science.gov (United States)

    Jafferis, W.; Hasbrouck, R. T.; Johnson, J. P.

    1992-01-01

    Faraday cage protects electronic and electronically actuated equipment from lightning. Follows standard lightning-protection principles. Whether lightning strikes cage or cables running to equipment, current canceled or minimized in equipment and discharged into ground. Applicable to protection of scientific instruments, computers, radio transmitters and receivers, and power-switching equipment.

  11. Cage-based performance capture

    CERN Document Server

    Savoye, Yann

    2014-01-01

    Nowadays, highly-detailed animations of live-actor performances are increasingly easier to acquire and 3D Video has reached considerable attentions in visual media production. In this book, we address the problem of extracting or acquiring and then reusing non-rigid parametrization for video-based animations. At first sight, a crucial challenge is to reproduce plausible boneless deformations while preserving global and local captured properties of dynamic surfaces with a limited number of controllable, flexible and reusable parameters. To solve this challenge, we directly rely on a skin-detached dimension reduction thanks to the well-known cage-based paradigm. First, we achieve Scalable Inverse Cage-based Modeling by transposing the inverse kinematics paradigm on surfaces. Thus, we introduce a cage inversion process with user-specified screen-space constraints. Secondly, we convert non-rigid animated surfaces into a sequence of optimal cage parameters via Cage-based Animation Conversion. Building upon this re...

  12. Joint prosthesis and method of bone fixation

    NARCIS (Netherlands)

    Oosterom, R.; Van der Pijl, A.J; Bersee, H.E.N.; Van der Helm, F.C.; Herder, J.L

    2006-01-01

    The invention relates to a joint prosthesis (10), for example, a knee joint or shoulder joint prosthesis comprising a first, socket-holding prosthesis part (11) for attachment to a first bone (12) and a second, ball-holding prosthesis part (13) for attachment to a second bone (14) that intermates wi

  13. 高水头抽水蓄能电站球阀与导叶联动的关闭规律研究%Study on Linkage Closing Rule between Ball Valve and Guide Vane in High Head Pumped Storage Power Station

    Institute of Scientific and Technical Information of China (English)

    张春; 杨建东

    2011-01-01

    针对高水头抽水蓄能电站机组甩负荷问题,以某抽水蓄能电站为例,采用导叶直线关闭规律及球阀与导叶联动的关闭规律进行探讨,并基于水泵水轮机全特性曲线进行数值模拟.结果表明,该规律能有效削减机组流量和蜗壳压力的第2峰值,最大值仍发生于第1波峰,而第1峰值则取决导叶初始(第1段)的关闭速度.%Aiming at the load shedding of hydroelectric sets in high head pumped storage power station, taking a pumped storage power station for an example, this paper discusses the straight-line closing rule of guide vane and linkage closing rule between ball valve and guide vane. And then the numerical calculation of pumped storage power station is simulated in terms of pump-turbine characteristic curve. The results show that the linkage closing rule can effectively reduce turbine flow and the second peak value of spiral case pressure while the maximum pressure remains to occur the first wave crest; the first peak pressure of spiral case depends on the initial (the first straight-line ) closing rate of the guide vane.

  14. Conus hip prosthesis.

    Science.gov (United States)

    Wagner, H; Wagner, M

    2001-01-01

    50 years ago, prosthetic replacement of the hip joint ushered in a new epoch in orthopaedics. Total hip replacement made it possible to remove a severely diseased, painful hip and restore normal function and a normal quality of life to the afflicted patient. The early results of total hip replacement are almost all spectacular and hip replacement has become the most successful type of orthopaedic surgery. These good results using an approach that was technically relatively simple resulted in a temptation to implant prosthetic hip joints with ever increasing frequency in ever younger patients. This led to the emergence of new problems, which were not so clearly recognised at the outset: it emerged that the stability of prosthetic hip joints was of limited duration. This had the following consequence: If a total hip prosthesis is implanted in an elderly person whose remaining life-expectancy is shorter than the longevity of the prosthesis, hip replacement is a life-long solution. We can therefore say that, for a patient who has only 10 to 15 years left to live, their hip problem is solved by total hip replacement. For young people, who still have a long life expectancy in front of them, it is different. They will experience failure of the artificial joint and require further surgery. The commonest and most important type of failure in total hip prostheses is aseptic loosening, which is associated with resorption of bone at the site of the prosthesis. The cause of this phenomenon has only gradually been recognised in the course of the years. Initially, the unanimous opinion was that the methacrylate cement, used to fix the components of the prosthesis in the bone, was the definitive cause of aseptic loosening because fissures and fractures of the cement were almost always found during surgical revision of loosened joints. There was talk of "cement disease" and great efforts were made to improve the quality of the cement and the cementing technique. Moreover, even

  15. Bioelectronic retinal prosthesis

    Science.gov (United States)

    Weiland, James D.

    2016-05-01

    Retinal prosthesis have been translated to clinical use over the past two decades. Currently, two devices have regulatory approval for the treatment of retinitis pigmentosa and one device is in clinical trials for treatment of age-related macular degeneration. These devices provide partial sight restoration and patients use this improved vision in their everyday lives to navigate and to detect large objects. However, significant vision restoration will require both better technology and improved understanding of the interaction between electrical stimulation and the retina. In particular, current retinal prostheses do not provide peripheral visions due to technical and surgical limitations, thus limiting the effectiveness of the treatment. This paper reviews recent results from human implant patients and presents technical approaches for peripheral vision.

  16. [Fracture of macroporous hydroxyapatite prosthesis].

    Science.gov (United States)

    Adetchessi, A T; Pech-Gourg, G; Metellus, P; Fuentes, S

    2012-12-01

    Different prosthesis implants are offered to perform a cranioplasty after a decompressive craniectomy when autologous bone graft cannot be used. The authors report the case of a 25-year-old man who benefited a unilateral decompressive craniectomy after a severe head trauma. Seven months later, a cranioplasty using custom macroporous hydroxyapatite prosthesis was performed. The postoperative course was marked by a generalized seizure leading to a traumatic head injury. The CT-scan showed a comminutive fracture of the prosthesis and an extradural hematoma. The patient underwent a removal of the fractured prosthesis and an evacuation of the extradural clot. The postoperative course was uneventful with a Glasgow outcome scale score at 5. A second cranioplasty using a polyether ether ketone (PEEK) implant was performed. Among cranioplasty prosthesis solutions, hydroxyapatite implants seem to have similar property to the bone. However, its weak mechanic resistance is an actual problem in patients susceptible to present generalized seizures with consecutive head impact. Hence, in patients with decompressive craniectomy who are exposed to potential brain injury, we favor the use of more resistant implant as PEEK prosthesis.

  17. 21 CFR 878.3550 - Chin prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Chin prosthesis. 878.3550 Section 878.3550 Food... DEVICES GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3550 Chin prosthesis. (a) Identification. A chin prosthesis is a silicone rubber solid device intended to be implanted to augment...

  18. 21 CFR 878.3720 - Tracheal prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Tracheal prosthesis. 878.3720 Section 878.3720...) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3720 Tracheal prosthesis. (a) Identification. The tracheal prosthesis is a rigid, flexible, or expandable tubular device made of a...

  19. 21 CFR 878.3610 - Esophageal prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Esophageal prosthesis. 878.3610 Section 878.3610...) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3610 Esophageal prosthesis. (a) Identification. An esophageal prosthesis is a rigid, flexible, or expandable tubular device...

  20. 21 CFR 878.3680 - Nose prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Nose prosthesis. 878.3680 Section 878.3680 Food... DEVICES GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3680 Nose prosthesis. (a) Identification. A nose prosthesis is a silicone rubber solid device intended to be implanted to augment...

  1. 21 CFR 878.3590 - Ear prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ear prosthesis. 878.3590 Section 878.3590 Food and... GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3590 Ear prosthesis. (a) Identification. An ear prosthesis is a silicone rubber solid device intended to be implanted to reconstruct the...

  2. 21 CFR 876.3750 - Testicular prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Testicular prosthesis. 876.3750 Section 876.3750...) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Prosthetic Devices § 876.3750 Testicular prosthesis. (a) Identification. A testicular prosthesis is an implanted device that consists of a solid or gel-filled...

  3. Choosing a Breast Prosthesis: A Survivor's Perspective

    Science.gov (United States)

    ... Choosing a Breast Prosthesis: A Survivor’s Perspective Choosing a Breast Prosthesis: A Survivor’s Perspective Andrea Zinn June 16, 2015 · Amber ... preferences. Q: Why did you decide to wear a breast form/prosthesis rather than have a reconstruction? ...

  4. A Mobile Phone Faraday Cage

    Science.gov (United States)

    French, M. M. J.

    2011-01-01

    A Faraday cage is an interesting physical phenomenon where an electromagnetic wave can be excluded from a volume of space by enclosure with an electrically conducting material. The practical application of this in the classroom is to block the signal to a mobile phone by enclosing it in a metal can. The background of the physics behind this is…

  5. Trabecular metal acetabular revision system (cup-cage construct to address the massive acetabular defects in revision arthroplasty

    Directory of Open Access Journals (Sweden)

    Rajesh Malhotra

    2012-01-01

    Full Text Available The increasing number of total hip replacements in the younger clique has added to the demand for revision procedures. Revision situations are often encountered with infection, loss of bone stock and bone defects. There are various methods of reconstruction of acetabular defects. The management options of type 3B Paprosky acetabular defects are limited with allograft and conventional cages. Trabecular metal technology has evolved to address these bone defects. Trabecular metal acetabular revision system (TMARS cup-cage construct is a new technique to address massive acetabular defects. We describe a case of failed hip reconstruction done for a Giant cell tumour of proximal femur managed by a two stage procedure, initial debridement and second stage reconstruction of acetabulum with TMARS cup-cage construct and femur with allograft prosthesis composite.

  6. Elektra prosthesis for trapeziometacarpal osteoarthritis

    DEFF Research Database (Denmark)

    Klahn, A; Nygaard, Mads; Gvozdenovic, R

    2012-01-01

    We present a prospective follow-up of 39 Elektra prostheses in 37 patients (32 women and five men), with a mean age of 56.5 (range 46-71) years; 34 patients had osteoarthritis and three had rheumatoid arthritis. Patients were followed using clinical examination, including measurement of pain...... be the key problem in treating trapeziometacarpal osteoarthritis using a total prosthesis....

  7. Prótesis de cuerpo vertebral JR: dispositivo modular, anatómico y expandible, con función de jaula y placa diseñada ad hoc para estabilizar la columna después de corpectomía Prótese do corpo vertebral JR: dispositivo modular, anatômico e expansível, com função de jaula e placa desenhada ad hoc para estabilizar a coluna depois da corpectomia JR vertebral body prosthesis: a modular, anatomical and expandable device, with cage function and plate dual designed ad hoc for spine stabilization after corpectomy

    Directory of Open Access Journals (Sweden)

    Juan José Ramírez Jiménez

    2009-06-01

    função de jaula e placa separadamente, uma vez que o desenho da prótese permite aplicar força axial e fixação lateral ao mesmo tempo, por meio de um só implante. Os resultados da colocação do implante no paciente foram satisfatórios.INTRODUCTION: due to the unsatisfactory results obtained with posterior instrumentations in cases of vertebral tumors and to the economical limitations of our patients for acquiring the systems available in the market, a vertebral body prosthesis to stabilize the spine after corpectomy was designed. OBJECTIVE: to describe the structural and functional characteristics of the JR prosthesis, the biomechanical assays in cadaver and the surgical technique on the patient. METHODS: firstly, it was performed a detailed anatomical study of the vertebral bodies. A design of a modular, anatomical and expandable device was obtained. Its components once assembled make an implant with expandable cage and plate dual function. Afterwards, a biomechanical assay was performed in a cadaver and the device was implanted in a patient with vertebral body metastasis. RESULTS: the radiographs extracted from the cadaver after implant location did not show loss of fixation. When the cadaver was raised, flexion moments were generated laterally with levers 80 cm long; therefore, the prosthesis was demanded in its most vulnerable point with a force of approximately 588 N. With rotation, flexion and extensions forced, stability was preserved and no movement was observed. The device was implanted in a 50-year-old woman with metastatic thyroid cancer affecting L3. Pain improved in the postoperative immediate, as well as its motor function, which allowed her to walk with a stable and painless spine for seven years. No implant failure was observed. CONCLUSION: the dual cage function and plate integrated in a single device offers a mechanical advantage, compared with the cages and plates used separately, since the prosthesis design permits to apply a distraction

  8. Artificial neural networks for automatic modelling of the pectus excavatum corrective prosthesis

    Science.gov (United States)

    Rodrigues, Pedro L.; Moreira, António H. J.; Rodrigues, Nuno F.; Pinho, ACM; Fonseca, Jaime C.; Correia-Pinto, Jorge; Vilaça, João. L.

    2014-03-01

    Pectus excavatum is the most common deformity of the thorax and usually comprises Computed Tomography (CT) examination for pre-operative diagnosis. Aiming at the elimination of the high amounts of CT radiation exposure, this work presents a new methodology for the replacement of CT by a laser scanner (radiation-free) in the treatment of pectus excavatum using personally modeled prosthesis. The complete elimination of CT involves the determination of ribs external outline, at the maximum sternum depression point for prosthesis placement, based on chest wall skin surface information, acquired by a laser scanner. The developed solution resorts to artificial neural networks trained with data vectors from 165 patients. Scaled Conjugate Gradient, Levenberg-Marquardt, Resilient Back propagation and One Step Secant gradient learning algorithms were used. The training procedure was performed using the soft tissue thicknesses, determined using image processing techniques that automatically segment the skin and rib cage. The developed solution was then used to determine the ribs outline in data from 20 patient scanners. Tests revealed that ribs position can be estimated with an average error of about 6.82+/-5.7 mm for the left and right side of the patient. Such an error range is well below current prosthesis manual modeling (11.7+/-4.01 mm) even without CT imagiology, indicating a considerable step forward towards CT replacement by a 3D scanner for prosthesis personalization.

  9. A mobile phone Faraday cage

    Science.gov (United States)

    French, M. M. J.

    2011-05-01

    A Faraday cage is an interesting physical phenomenon where an electromagnetic wave can be excluded from a volume of space by enclosure with an electrically conducting material. The practical application of this in the classroom is to block the signal to a mobile phone by enclosing it in a metal can. The background of the physics behind this is described in some detail, and this is followed by a explanation of some demonstrations and experiments which I have used.

  10. The caged state of some small molecules in the C60 cage

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The potential energy curves of some small molecules, H2, N2, O2, F2, HF, CO and NO, in the caged state within C60 cage and in the free state have been calculated by the quantum-chemical method AM1. In this study, the focus is on the cage effect of C60, and the concept of caged state is put forward. The results show that the bond lengths in the caged states are not much different from those in their corresponding free states, but the bond intensities in the caged states are much greater than those in their corresponding free states.

  11. Polymers containing borane or carborane cage compounds and related applications

    Science.gov (United States)

    Bowen, III, Daniel E; Eastwood, Eric A

    2013-04-23

    Polymers comprising residues of cage compound monomers having at least one polyalkoxy silyl substituent are provided. The cage compound monomers are selected from borane cage compound monomers comprising at least 7 cage atoms and/or carborane cage compound monomers comprising 7 to 11 cage compound monomers. Such polymers can further comprise one or more reactive matrices and/or co-monomers covalently bound with the cage compound monomer residues. Articles of manufacture comprising such polymers are also disclosed.

  12. Tracheostomy cannulas and voice prosthesis.

    Science.gov (United States)

    Kramp, Burkhard; Dommerich, Steffen

    2009-01-01

    Cannulas and voice prostheses are mechanical aids for patients who had to undergo tracheotomy or laryngectomy for different reasons. For better understanding of the function of those artificial devices, first the indications and particularities of the previous surgical intervention are described in the context of this review. Despite the established procedure of percutaneous dilatation tracheotomy e.g. in intensive care units, the application of epithelised tracheostomas has its own position, especially when airway obstruction is persistent (e.g. caused by traumata, inflammations, or tumors) and a longer artificial ventilation or special care of the patient are required. In order to keep the airways open after tracheotomy, tracheostomy cannulas of different materials with different functions are available. For each patient the most appropriate type of cannula must be found. Voice prostheses are meanwhile the device of choice for rapid and efficient voice rehabilitation after laryngectomy. Individual sizes and materials allow adaptation of the voice prostheses to the individual anatomical situation of the patients. The combined application of voice prostheses with HME (Head and Moisture Exchanger) allows a good vocal as well as pulmonary rehabilitation. Precondition for efficient voice prosthesis is the observation of certain surgical principles during laryngectomy. The duration of the prosthesis mainly depends on material properties and biofilms, mostly consisting of funguses and bacteries. The quality of voice with valve prosthesis is clearly superior to esophagus prosthesis or electro-laryngeal voice. Whenever possible, tracheostoma valves for free-hand speech should be applied. Physicians taking care of patients with speech prostheses after laryngectomy should know exactly what to do in case the device fails or gets lost.

  13. Behaviour of Sub Prosthesis Stomatitis in Patients with Upper Dental Prosthesis

    Directory of Open Access Journals (Sweden)

    Yoel González Beriau

    2017-02-01

    Full Text Available Foundation: Sub prosthesis stomatitis is one of the most frequent affections in patients who wear dental prosthesis and constitutes a risk factor for the appearance of pre malignant and malignant lesions in the oral cavity.Objective: To describe the behaviour of sub prosthesis stomatitis in patients with upper dental prosthesis.Methods: A descriptive study was carried out, of all the patients who wear upper dental prosthesis (N=61 who came to the consultation due to sub prosthesis stomatitis, in the period from September 2014 to September 2015. The variables analyzed were: Age groups, sex, degree of the lesion, state of the prosthesis, toxic habits, location of the lesion and frequency of visits to the dentist.Results: Old adults predominated (54.1% and sub prosthesis Stomatitis degree II, represented by 77%. Unadjusted prosthesis was observed in most patients and the lesions were located more frequently in mix zones. The most frequent toxic habits were continuous use and deficient oral hygiene. 85.2% of the patients reported to have visited the dentist only when they felt discomforts.Conclusion: Some results show patients ignorance about this ailment, among them a high frequency of toxic habits so as the use of continuous use of prosthesis and deficient oral hygiene, factors which condition the appearance of sub prosthesis stomatitis.

  14. Penile prosthesis implantation: past, present and future.

    Science.gov (United States)

    Simmons, M; Montague, D K

    2008-01-01

    Penile prosthesis implantation is the oldest effective treatment for erectile dysfunction. This review examines the past, present and future of penile prosthesis implantation. Advances in prosthetic design and implantation techniques have resulted today in devices that produce nearly normal flaccid and erect states, and have remarkable freedom from mechanical failure. The future of prosthetic design holds promises for even more improvements.

  15. Nasal prosthesis rehabilitation: a case report

    DEFF Research Database (Denmark)

    Jain, Sumeet; Maru, Kavita; Shukla, Jyotsana

    2011-01-01

    Facial defects resulting from neoplasm, congenital malformation or trauma can be restored with facial prosthesis using different materials and retention methods to achieve life-like look and function. A nasal prosthesis can re-establish esthetic form and anatomic contours for mid-facial defects...

  16. Parametric modelling of a knee joint prosthesis.

    Science.gov (United States)

    Khoo, L P; Goh, J C; Chow, S L

    1993-01-01

    This paper presents an approach for the establishment of a parametric model of knee joint prosthesis. Four different sizes of a commercial prosthesis are used as an example in the study. A reverse engineering technique was employed to reconstruct the prosthesis on CATIA, a CAD (computer aided design) system. Parametric models were established as a result of the analysis. Using the parametric model established and the knee data obtained from a clinical study on 21 pairs of cadaveric Asian knees, the development of a prototype prosthesis that suits a patient with a very small knee joint is presented. However, it was found that modification to certain parameters may be inevitable due to the uniqueness of the Asian knee. An avenue for rapid modelling and eventually economical production of a customized knee joint prosthesis for patients is proposed and discussed.

  17. Jules Verne's Metaphor of the Iron Cage

    NARCIS (Netherlands)

    Ossewaarde, M.R.R.

    2010-01-01

    Max Weber's concept of the iron cage has become a byword in the scholarly world since the publication in 1930 of Talcott Parsons’ translation of The Protestant Ethic and the Spirit of Capitalism. What is less well-known is that Jules Verne had earlier used the iron cage metaphor in Twenty Thousand L

  18. Particle cage dynamics in flowing colloidal dispersions

    Science.gov (United States)

    Marenne, Stephanie; Morris, Jeffrey F.

    2016-11-01

    The idea of the particle in a suspension at rest being trapped in a cage formed by its neighbors, widely used to understand glassy suspensions, has been applied to freely flowing suspensions. Stokesian Dynamics, a discrete particle simulation, is used to simulate the flow of monodisperse colloidal hard sphere suspensions. The cage analogy is useful to study the nonlinear stress in the material during start-up of shear flow, where the neighbor cage deforms and breaks, and during oscillatory shear flow where, depending on the amplitude of oscillation, the particle is trapped inside the cage or escapes during the oscillation cycle. A precise statistical definition of the cage in terms of the nearest neighbor ring in the pair distribution function is developed. We examine the dependence of the cage dynamics on the volume fraction of particles and the Peclet number Pe , the ratio between shear and Brownian forces. Under flow, the cage is found to break at quite definite positions, and the structural distortion is found to be clearly related to the shear and normal stress response. The shear strain needed to break the neighbor cage depends on Pe as Brownian motion enhances the total deformation. A simple model captures the strain at the stress overshoot for start-up of steady shear.

  19. Smartphone supported upper limb prosthesis

    Directory of Open Access Journals (Sweden)

    Hepp D.

    2015-09-01

    Full Text Available State of the art upper limb prostheses offer up to six active DoFs (degrees of freedom and are controlled using different grip patterns. This low number of DoFs combined with a machine-human-interface which does not provide control over all DoFs separately result in a lack of usability for the patient. The aim of this novel upper limb prosthesis is both offering simplified control possibilities for changing grip patterns depending on the patients’ priorities and the improvement of grasp capability. Design development followed the design process requirements given by the European Medical Device Directive 93/42 ECC and was structured into the topics mechanics, software and drive technology. First user needs were identified by literature research and by patient feedback. Consequently, concepts were evaluated against technical and usability requirements. A first evaluation prototype with one active DoF per finger was manufactured. In a second step a test setup with two active DoF per finger was designed. The prototype is connected to an Android based smartphone application. Two main grip patterns can be preselected in the software application and afterwards changed and used by the EMG signal. Three different control algorithms can be selected: “all-day”, “fine” and “tired muscle”. Further parameters can be adjusted to customize the prosthesis to the patients’ needs. First patient feedback certified the prosthesis an improved level of handling compared to the existing devices. Using the two DoF test setup, the possibilities of finger control with a neural network are evaluated at the moment. In a first user feedback test, the smartphone based software application increased the device usability, e.g. the change within preselected grip patterns and the “tired muscle” algorithm. Although the overall software application was positively rated, the handling of the prosthesis itself needs to be proven within a patient study to be

  20. 21 CFR 878.3530 - Silicone inflatable breast prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Silicone inflatable breast prosthesis. 878.3530... inflatable breast prosthesis. (a) Identification. A silicone inflatable breast prosthesis is a silicone... inflatable breast prosthesis that was in commercial distribution before May 28, 1976, or that has, on...

  1. 21 CFR 878.3800 - External aesthetic restoration prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false External aesthetic restoration prosthesis. 878... External aesthetic restoration prosthesis. (a) Identification. An external aesthetic restoration prosthesis... external prosthesis adhesive. The device is not intended to be implanted. (b) Classification. Class...

  2. Synthesis, Chemistry, and Applications of Heterocyclic Cage Compounds (V)

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@ The synthesis and chemistry of polycyclic of cage compounds have attracted considerable attention in recent years. The vast majority of the work reported in this area has dealt with carbocylic cage compounds. On the other hand, the synthesis and chemistry of heterocyclic cage compounds have received less attention. Recently, we envisioned that studies on the synthesis and chemistry of heterocyclic cage compounds can greatly expand the scopes and utilities of cage compounds.1 As part of a program that involves the synthesis, chemistry, and application of heterocyclic cage compounds, we report here the synthesis of new thia-oxa-cage compounds and the chemical nature of these thia-cages.

  3. Retinal prosthesis for the blind.

    Science.gov (United States)

    Margalit, Eyal; Maia, Mauricio; Weiland, James D; Greenberg, Robert J; Fujii, Gildo Y; Torres, Gustavo; Piyathaisere, Duke V; O'Hearn, Thomas M; Liu, Wentai; Lazzi, Gianluca; Dagnelie, Gislin; Scribner, Dean A; de Juan, Eugene; Humayun, Mark S

    2002-01-01

    Most of current concepts for a visual prosthesis are based on neuronal electrical stimulation at different locations along the visual pathways within the central nervous system. The different designs of visual prostheses are named according to their locations (i.e., cortical, optic nerve, subretinal, and epiretinal). Visual loss caused by outer retinal degeneration in diseases such as retinitis pigmentosa or age-related macular degeneration can be reversed by electrical stimulation of the retina or the optic nerve (retinal or optic nerve prostheses, respectively). On the other hand, visual loss caused by inner or whole thickness retinal diseases, eye loss, optic nerve diseases (tumors, ischemia, inflammatory processes etc.), or diseases of the central nervous system (not including diseases of the primary and secondary visual cortices) can be reversed by a cortical visual prosthesis. The intent of this article is to provide an overview of current and future concepts of retinal and optic nerve prostheses. This article will begin with general considerations that are related to all or most of visual prostheses and then concentrate on the retinal and optic nerve designs. The authors believe that the field has grown beyond the scope of a single article so cortical prostheses will be described only because of their direct effect on the concept and technical development of the other prostheses, and this will be done in a more general and historic perspective.

  4. Lower limb prosthesis utilisation by elderly amputees.

    Science.gov (United States)

    Bilodeau, S; Hébert, R; Desrosiers, J

    2000-08-01

    The goal of prosthetic rehabilitation is to compensate for the loss of a limb by amputation by, in the case of a lower limb, encouraging walking, and to achieve the same level of autonomy as prior to the amputation. However, because of difficulties walking, elderly amputees may use their prosthesis to a greater or lesser degree or simply stop using it during the rehabilitation period. The objective of this research was to study factors such as physical and mental health, rehabilitation, physical independence and satisfaction with the prosthesis to understand why amputees use their prosthesis or not. The sample was composed of 65 unilateral vascular amputees 60 years old or over living at home. The information was collected from medical records, by telephone interview and by mail questionnaire. Prosthesis use was measured by a questionnaire on amputee activities developed by Day (1981). Eighty-one per cent (81%) of the subjects wore their prosthesis every day and 89% of this group wore it 6 hours or more per day. Less use of the prosthesis was significantly related to age, female gender, possession of a wheelchair, level of physical disability, cognitive impairment, poorer self-perceived health and the amputee's dissatisfaction. A multiple regression analysis showed that satisfaction, not possessing a wheelchair and cognitive integrity explained 46% of the variance in prosthesis use.

  5. Some exclusion cages do not exclude predators

    Directory of Open Access Journals (Sweden)

    Olga M. C. C. Ameixa

    2011-12-01

    Full Text Available Exclusion techniques, such as cages, are the most frequently used means of evaluating the efficiency of natural enemies in suppressing the abundance of their prey. The growth rates and peak densities of aphid populations within cages are usually larger than those in uncaged populations. However, cages change the microenvironment and prevent aphids from emigrating. Attempts were made to avoid the change in the microenvironment by using cages with a large (8 mm mesh. Here we test the hypothesis that because of the large mesh size, predators can easily penetrate into such cages during an experiment. Our results have shown that cages with a large (8 mm mesh size do not prevent predators from entering the cages and therefore cannot be used as “exclusion cages” for measuring the effect of predators on aphid numbers. Other methods of assessing the effectiveness of natural enemies in reducing the abundance of their prey, like removing the predators or direct observations, should be used instead.

  6. Prosthesis infections after orthopedic joint replacement

    DEFF Research Database (Denmark)

    Song, Zhijun; Borgwardt, Lotte; Høiby, Niels;

    2013-01-01

    Prosthesis-related infection is a serious complication for patients after orthopedic joint replacement, which is currently difficult to treat with antibiotic therapy. Consequently, in most cases, removal of the infected prosthesis is the only solution to cure the infection. It is, therefore...... and the host immune responses. The authors reviewed the related literature in the context of their clinical experience, and discussed the possible etiology and mechanism leading to the infections, especially problems related to bacterial biofilm, and prophylaxis and treatment of infection, including both...... microbiological and surgical measures. Recent progress in research into bacterial biofilm and possible future treatment options of prosthesis-related infections are discussed....

  7. Stemless shoulder prosthesis versus conventional anatomic shoulder prosthesis in patients with osteoarthritis

    OpenAIRE

    Berth, Alexander; Pap, Géza

    2012-01-01

    Background The stemless shoulder prosthesis is a new concept in shoulder arthroplasty. To date, only a few studies have investigated the results of this prosthesis. The aim of this study was to investigate the clinical and radiological midterm results of this implant in comparison with a standard anatomic stemmed shoulder prosthesis. Materials and methods The Constant score, the DASH score, the active range of motion (abduction, anteversion, external rotation), and the radiological results we...

  8. Active cage model of glassy dynamics

    Science.gov (United States)

    Fodor, Étienne; Hayakawa, Hisao; Visco, Paolo; van Wijland, Frédéric

    2016-07-01

    We build up a phenomenological picture in terms of the effective dynamics of a tracer confined in a cage experiencing random hops to capture some characteristics of glassy systems. This minimal description exhibits scale invariance properties for the small-displacement distribution that echo experimental observations. We predict the existence of exponential tails as a crossover between two Gaussian regimes. Moreover, we demonstrate that the onset of glassy behavior is controlled only by two dimensionless numbers: the number of hops occurring during the relaxation of the particle within a local cage and the ratio of the hopping length to the cage size.

  9. Custom ocular prosthesis: A palliative approach

    Directory of Open Access Journals (Sweden)

    Prachi Thakkar

    2015-04-01

    Full Text Available The goal of palliative care is the achievement of the best quality of life for patients and their families. Eyes are generally the first features of the face to be noticed. Loss of an eye is a traumatic event which has a crippling effect on the psychology of the patient. Several ocular and orbital disorders require surgical intervention that may result in ocular defects. An ocular prosthesis is fabricated to restore the structure, function, and cosmetics of the defects created by such conditions. Although an implant eye prosthesis has a superior outcome, due to economic factors it may not be a feasible option for all patients. Therefore, a custom-made ocular prosthesis is a good alternative. This case report presents a palliative treatment for a patient with an enucleated eye by fabricating a custom ocular prosthesis which improved his psychological, physical, social, functional, emotional and spiritual needs.

  10. Penile prosthesis implantation in a transsexual neophallus

    Institute of Scientific and Technical Information of China (English)

    Hui-MengTAN

    2000-01-01

    Reconstruction surgery for a female to male transsexual usually involves mastectomy, hysterectomy and creating an aesthetically appealing neophallus. We have successfully inserted an inflatable prosthesis using the AMS CX prosthesis in a 45 year old transsexual, who had a large bulky neophallus constructed from the anterior abdominal subcutaneous fat, about 9 years ago. The single cylinder CX prosthesis was well anchored to the symphysis pubis using a dacron windsock tubing, the activation pump was placed in the dependent pouch of the right labium and the reservior in the usual perivesical space. The patient subsequently had debulking procedure using liposuction to create a more aesthetic and functional phallus. To date, the inflatable neophallus prosthesis is functioning well. (Asian J Androl 2000 Dec;2:304-306)

  11. Aesthetic finger prosthesis with silicone biomaterial

    Science.gov (United States)

    Raghu, K M; Gururaju, C R; Sundaresh, K J; Mallikarjuna, Rachappa

    2013-01-01

    The fabrication of finger prosthesis is as much an art as it is science. The ideally constructed prosthesis must duplicate the missing structures so precisely that patients can appear in public without fear of attracting unwanted attraction. A 65-years-old patient reported with loss of his right index finger up to the second phalanx and wanted to get it replaced. An impression of the amputated finger and donor were made. A wax pattern of the prosthesis was fabricated using the donor impression; a trial was performed and flasked. Medical grade silicone was intrinsically stained to match the skin tone, following which it was packed, processed and finished. This clinical report describes a method of attaining retention by selective scoring of the master cast of partially amputated finger to enhance the vacuum effect at par with the proportional distribution of the positive forces on the tissues exerted by the prosthesis. PMID:23975917

  12. Finger prosthesis: a boon to handicapped.

    Science.gov (United States)

    Gupta, Ridhima; Kumar, Lakshya; Rao, Jitendra; Singh, Kamleshwar

    2013-08-29

    This is a clinical case report of a 52-year-old male patient with four partially missing fingers of the left hand. The article describes the clinical and laboratory procedure of making prosthesis with modern silicone material. A wax pattern was fabricated using the right hand of the patient. A special type of wax was formulated to make the pattern so that it can be easily moulded and carved. Intrinsic and extrinsic staining was also performed to match the adjacent skin colour. The patient was given the finger prosthesis and was asked to use a half glove (sports) to mask the junction between the prosthesis and the normal tissue. It also provides additional retention to the artificial fingers. The patient felt his social acceptance improved after wearing the finger prosthesis.

  13. Synthesis of Caged Bicyclic Phosphate Derivatives

    Institute of Scientific and Technical Information of China (English)

    FANG Xiao-min; OU Yu-xiang; LUO Rui-bin; WANG Yong; LIAN Dan-jun; LI Xin

    2008-01-01

    Seven caged bicyclic phosphate compounds were synthesized by using 1-oxo-4-hydroxymethy1-2,6,7-trioxa-1-pho-sphabicyclo[2.2.2] octane (PEPA) as starting material. Within them were three PEPA derivatives containing single caged bicyclic phosphate structure(1a,2a,3a), another three PEPA deviratives containing two caged bicyclic phosphate structures(1b,2b,3b) and one devirative(1c) containing three caged bicyclic phosphate structures. Structures of the products were characterized by FTIR, 1H NMR, elemental analysis and TG analysis. The reaction conditions were also discussed. Thermal analysis showed they had high thermal stability and excellent char-forming ability. Besides, these compounds had pentaerythritol bone and flame retardant elements of phosphorus, bromine or nitrogen simultaneously in their molecules, endowed them with good fire retardancy, and made them can be used as intumescent flame retardant.

  14. Working papers cage Mod 2A definitions

    Energy Technology Data Exchange (ETDEWEB)

    Sprouse, L.D.

    1969-01-30

    This report presents working papers for the Cage Mod 2A program. Cost data are presented for manpower, irradiation, nuclear fuels and targets, security, transportation, reactor start-up and reactor shutdown.

  15. Updating upper extremity temporary prosthesis: thermoplastics.

    Science.gov (United States)

    Fletchall, S; Tran, T; Ungaro, V; Hickerson, W

    1992-01-01

    Since 1989 amputees with upper-extremity burns have been fitted with a temporary prosthesis fabricated from low-temperature thermoplastic. Before 1989 conventional temporary prostheses were fabricated with plaster. The use of the thermoplastic material has produced a lightweight, cost-effective, modular system. No patients exhibited skin breakdown with the thermoplastic material. It appears that thermoplastics may be the next major breakthrough in terms of a design for a temporary upper-extremity prosthesis.

  16. NMR Evidence of Cage-to-Cage Diffusion of H2 in H2-Clathrates

    Science.gov (United States)

    Senadheera, Lasitha; Conradi, Mark

    2008-03-01

    H2 and heavy-ice at P>1 kbar and T ˜250 K form H2-D2O clathrate; four and one H2 may occupy each large (L) and small (S) cage, respectively. In H2-THF-H2O clathrate, H2 occupies singly and only S cages. Previous electronic-structure calculations estimate the barriers for H2 passage though hexagonal and pentagonal faces of cages as ˜6 and ˜25 kcal/mol, respectively. Our H2 NMR linewidth data reflect random crystal fields from frozen cage-wall D2O orientations. We find dramatic reductions in linewidth starting at 120 K (175 K) for H2-D2O (H2-TDF-D2O) indicating time-averaging of the crystal fields. Assuming Arrhenius behavior, our data imply energies for escape from L (S) cages of about ˜4 (˜6) kcal/mol. For L cages, the agreement with the calculated (cages were treated as rigid) barrier is reasonable. For H2 in S cages, in H2-TDF-D2O, the extreme disagreement with theory points to another mechanism of time-averaging, reorientations of the cage-wall D2O molecules, as suggested by previous work in TDH-H2O clathrate. Our limited NMR spectra at high T ˜145 K in H2-D2O show evidence of distinct resonances from diffusionally mobile and immobile H2 molecules, as expected.

  17. Self-Assembled Pyridine-Dipyrrolate Cages.

    Science.gov (United States)

    Zhang, Huacheng; Lee, Juhoon; Lammer, Aaron D; Chi, Xiaodong; Brewster, James T; Lynch, Vincent M; Li, Hao; Zhang, Zhan; Sessler, Jonathan L

    2016-04-06

    An inherently nonlinear pyridine dipyrrolate ligand, namely 2,6-bis(3,4-diethyl-5-carboxy-1H-pyrrol-2yl)pyridine (compound 1), is able to distinguish between different zinc(II) cation sources, namely Zn(acac)2 and Zn(OAc)2, respectively. This differentiation is manifest both in terms of the observed fluorescent behavior in mixed organic media and the reaction chemistry. Treatment of 1 with Zn(acac)2 gives rise to a cage dimer, cage-1, wherein two molecules of compound 1 act as double bridging units to connect two individual cage subunits. As inferred from X-ray crystallographic studies, this cage system consists of discrete zinc dimers with hydroxide bridges that, with the assistance of bound DMF solvent molecules, serve to fix the geometry and orientation of the pyridine dipyrrolate building blocks. When a different zinc source, Zn(OAc)2, is used to carry out an ostensibly similar complexation reaction with compound 1, an acetate-bridged 1D abacus-like cage polymer is obtained as inferred from X-ray diffraction analysis. This extended solid state structure, cage-2, contains individual zinc dimer cage submits and appears stabilized by solvent molecules (DMF) and the counteranion (acetate). Rod-like assemblies are also observed by DLS and SEM. This construct, in contrast to cage-1, proved fluorescent in mixed organic media. The structure of the ligand itself (i.e., in the absence of Zn(II)) was confirmed by X-ray crystallographic analysis and was found to assemble into a supramolecular polymer. Conversion to a dimer form was seen upon the addition of TBAOAc. On the basis of the metric parameters, the structures seen in the solid state are stabilized via hydrogen bonding interactions involving solvent molecules.

  18. BELOW-ELBOW COSMETIC CONDYLE-SUSPENDED PROSTHESIS

    Science.gov (United States)

    particular appeal to those amputees who desire a prosthesis for cosmetic reasons. However this type of prosthesis can be so built to provide a means for operating the active mechanical terminal device. (Author)

  19. Usefulness of the "CAGE" in Malaysia.

    Science.gov (United States)

    Indran, S K

    1995-04-01

    This study examines the usefulness of the "CAGE", (which is an acronym for "cut down", "annoyed", "guilty" and "eye-opener"), a 4-question screening test to identify excessive drinkers among Malaysian inpatients. The CAGE questionnaire after translation and back translation was administered to all inpatients in the General Hospital, Kuala Lumpur. The author interviewed 'blindly' all who score positive on the CAGE score and 10% of all negatives using the DSM III interview schedule for alcohol abuse dependence. The results show that the CAGE performs best at a cut-off point of 2 and above, with a sensitivity of 92%, specificity of 62%, positive predictive values of 38% and Kappa (K) of 0.37 with a DSM III R diagnosis for alcohol abuse/dependence. The poor agreement with a DSM III diagnosis indicates that the CAGE is not useful in the Malaysian population. Reasons suggested for this are: cultural factors in the Malaysian population resulting in the overrating of the question of 'guilt' by Muslims and translations into the local languages which are only the closest approximations.

  20. Life Estimation of Hip Joint Prosthesis

    Science.gov (United States)

    Desai, C.; Hirani, H.; Chawla, A.

    2014-11-01

    Hip joint is one of the largest weight-bearing structures in the human body. In the event of a failure of the natural hip joint, it is replaced with an artificial hip joint, known as hip joint prosthesis. The design of hip joint prosthesis must be such so as to resist fatigue failure of hip joint stem as well as bone cement, and minimize wear caused by sliding present between its head and socket. In the present paper an attempt is made to consider both fatigue and wear effects simultaneously in estimating functional-life of the hip joint prosthesis. The finite element modeling of hip joint prosthesis using HyperMesh™ (version 9) has been reported. The static analysis (load due to the dead weight of the body) and dynamic analysis (load due to walking cycle) have been described. Fatigue life is estimated by using the S-N curve of individual materials. To account for progressive wear of hip joint prosthesis, Archard's wear law, modifications in socket geometry and dynamic analysis have been used in a sequential manner. Using such sequential programming reduction in peak stress has been observed with increase in wear. Finally life is estimated on the basis of socket wear.

  1. THE ENDO-EXO-FEMORAL PROSTHESIS

    Directory of Open Access Journals (Sweden)

    H. Aschoff

    2011-01-01

    Full Text Available Patients with above knee amputation (AKA face many challenges to mobility including difficulty with socket fit and fatigue due to high energy consumption. The aim of the Endo-Exo-Femur Prosthesis (EEFP is to avoid problems at the interface between the sleeve of the socket-prosthesis and the soft tissue coat of the femur stump which often impedes an inconspicuous and harmonic gait. In 1999 we began using a transcutaneous, press-fit distal femoral intramedullary device whose most distal external aspect serves as a hard point for AKA prosthesis attachment. The bone guided prosthesis enables an advanced gait via osseoperception and leads to a decreased oxygen consumption of the patient. Thirty two patients underwent the procedure between 1999 and 2008. Their indication for surgery was persistent AKA prosthesis difficulties with a history of AKA for trauma. The paper presents the patient data regarding the design of the implant, the operative procedure, patient satisfaction, gait analysis and oxygen consumption.

  2. Robotic lower limb prosthesis design through simultaneous computer optimizations of human and prosthesis costs

    Science.gov (United States)

    Handford, Matthew L.; Srinivasan, Manoj

    2016-02-01

    Robotic lower limb prostheses can improve the quality of life for amputees. Development of such devices, currently dominated by long prototyping periods, could be sped up by predictive simulations. In contrast to some amputee simulations which track experimentally determined non-amputee walking kinematics, here, we explicitly model the human-prosthesis interaction to produce a prediction of the user’s walking kinematics. We obtain simulations of an amputee using an ankle-foot prosthesis by simultaneously optimizing human movements and prosthesis actuation, minimizing a weighted sum of human metabolic and prosthesis costs. The resulting Pareto optimal solutions predict that increasing prosthesis energy cost, decreasing prosthesis mass, and allowing asymmetric gaits all decrease human metabolic rate for a given speed and alter human kinematics. The metabolic rates increase monotonically with speed. Remarkably, by performing an analogous optimization for a non-amputee human, we predict that an amputee walking with an appropriately optimized robotic prosthesis can have a lower metabolic cost – even lower than assuming that the non-amputee’s ankle torques are cost-free.

  3. 21 CFR 870.3450 - Vascular graft prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Vascular graft prosthesis. 870.3450 Section 870... prosthesis. (a) Identification. A vascular graft prosthesis is an implanted device intended to repair... Prostheses 510(k) Submissions.”...

  4. 21 CFR 872.3950 - Glenoid fossa prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Glenoid fossa prosthesis. 872.3950 Section 872...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3950 Glenoid fossa prosthesis. (a) Identification. A glenoid fossa prosthesis is a device that is intended to be implanted in the...

  5. 21 CFR 888.3720 - Toe joint polymer constrained prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Toe joint polymer constrained prosthesis. 888.3720 Section 888.3720 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... prosthesis. (a) Identification. A toe joint polymer constrained prosthesis is a device made of...

  6. 21 CFR 890.3500 - External assembled lower limb prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false External assembled lower limb prosthesis. 890.3500... External assembled lower limb prosthesis. (a) Identification. An external assembled lower limb prosthesis... the lower extremity. Examples of external assembled lower limb prostheses are the following:...

  7. 21 CFR 888.3780 - Wrist joint polymer constrained prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Wrist joint polymer constrained prosthesis. 888.3780 Section 888.3780 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... constrained prosthesis. (a) Identification. A wrist joint polymer constrained prosthesis is a device made...

  8. 21 CFR 874.3450 - Partial ossicular replacement prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Partial ossicular replacement prosthesis. 874.3450 Section 874.3450 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... replacement prosthesis. (a) Identification. A partial ossicular replacement prosthesis is a device intended...

  9. 21 CFR 884.3650 - Fallopian tube prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Fallopian tube prosthesis. 884.3650 Section 884.3650 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... § 884.3650 Fallopian tube prosthesis. (a) Identification. A fallopian tube prosthesis is a...

  10. 21 CFR 888.3230 - Finger joint polymer constrained prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Finger joint polymer constrained prosthesis. 888... constrained prosthesis. (a) Identification. A finger joint polymer constrained prosthesis is a device intended... generic type of device includes prostheses that consist of a single flexible across-the-joint...

  11. 21 CFR 874.3495 - Total ossicular replacement prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Total ossicular replacement prosthesis. 874.3495 Section 874.3495 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... replacement prosthesis. (a) Identification. A total ossicular replacement prosthesis is a device intended...

  12. 21 CFR 874.3695 - Mandibular implant facial prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Mandibular implant facial prosthesis. 874.3695... (CONTINUED) MEDICAL DEVICES EAR, NOSE, AND THROAT DEVICES Prosthetic Devices § 874.3695 Mandibular implant facial prosthesis. (a) Identification. A mandibular implant facial prosthesis is a device that...

  13. 21 CFR 872.3960 - Mandibular condyle prosthesis.

    Science.gov (United States)

    2010-04-01

    ... (CONTINUED) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3960 Mandibular condyle prosthesis. (a) Identification. A mandibular condyle prosthesis is a device that is intended to be implanted in the human jaw to... requirement for premarket approval for any mandibular condyle prosthesis intended to be implanted in the...

  14. 21 CFR 888.3025 - Passive tendon prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Passive tendon prosthesis. 888.3025 Section 888...) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3025 Passive tendon prosthesis. (a) Identification. A passive tendon prosthesis is a device intended to be implanted made of silicon elastomer or...

  15. Temperature dependence of polyhedral cage volumes in clathrate hydrates

    Science.gov (United States)

    Chakoumakos, B.C.; Rawn, C.J.; Rondinone, A.J.; Stern, L.A.; Circone, S.; Kirby, S.H.; Ishii, Y.; Jones, C.Y.; Toby, B.H.

    2003-01-01

    The polyhedral cage volumes of structure I (sI) (carbon dioxide, methane, trimethylene oxide) and structure II (sII) (methane-ethane, propane, tetrahydrofuran, trimethylene oxide) hydrates are computed from atomic positions determined from neutron powder-diffraction data. The ideal structural formulas for sI and sII are, respectively, S2L6 ?? 46H2O and S16L???8 ?? 136H2O, where S denotes a polyhedral cage with 20 vertices, L a 24-cage, and L??? a 28-cage. The space-filling polyhedral cages are defined by the oxygen atoms of the hydrogen-bonded network of water molecules. Collectively, the mean cage volume ratio is 1.91 : 1.43 : 1 for the 28-cage : 24-cage : 20-cage, which correspond to equivalent sphere radii of 4.18, 3.79, and 3.37 A??, respectively. At 100 K, mean polyhedral volumes are 303.8, 227.8, and 158.8 A??3 for the 28-cage, 24-cage, and 20-cage, respectively. In general, the 20-cage volume for a sII is larger than that of a sI, although trimethylene oxide is an exception. The temperature dependence of the cage volumes reveals differences between apparently similar cages with similar occupants. In the case of trimethylene oxide hydrate, which forms both sI and sII, the 20-cages common to both structures contract quite differently. From 220 K, the sII 20-cage exhibits a smooth monotonic reduction in size, whereas the sI 20-cage initially expands upon cooling to 160 K, then contracts more rapidly to 10 K, and overall the sI 20-cage is larger than the sII 20-cage. The volumes of the large cages in both structures contract monotonically with decreasing temperature. These differences reflect reoriented motion of the trimethyelene oxide molecule in the 24-cage of sI, consistent with previous spectroscopic and calorimetric studies. For the 20-cages in methane hydrate (sI) and a mixed methane-ethane hydrate (sII), both containing methane as the guest molecule, the temperature dependence of the 20-cage volume in sII is much less than that in sI, but sII is overall

  16. Contact dermatitis to a limb prosthesis.

    Science.gov (United States)

    Sood, Apra; Taylor, James S; Billock, John N

    2003-09-01

    PROSTHESIS USERS commonly develop various skin problems on the residual limb, directly under the prosthetic device when the device is in direct contact with the skin. Prolonged occlusion and humidity increase the likelihood of developing contact sensitivity to moisturizing creams, medicaments, and materials in the prosthesis itself.1 Allergic contact dermatitis to various prosthetic design materials is uncommon, and the relevance of positive patch-test results to chemicals present in prostheses may be difficult to establish. Most reports of allergic contact dermatitis to prostheses have been concerned with surgical amputees and not congenital amputees. We report a 5-year-old boy with a transverse partial hemimelia who developed allergic contact dermatitis to an adhesive used in his myoelectric prosthesis. Unlike most prostheses, myoelectric prostheses are worn directly against the skin, for surface electromyography electrode contact.

  17. Groningen prosthesis for voice rehabilitation after laryngectomy.

    Science.gov (United States)

    Annyas, A A; Nijdam, H F; Escajadillo, J R; Mahieu, H F; Leever, H

    1984-02-01

    Singer and Blom's endoscopic technique, using a single valved silicone prosthesis, constituted a dramatic advance in speech rehabilitation following total laryngectomy. Since 1980, we have developed a silicone biflanged prosthesis that overcomes some of the inconveniences of previous prostheses. Insertion via the mouth and the oesophagus, or as a primary procedure during total laryngectomy is easily done with the use of specially developed instruments. The success rate in 36 patients in which the voice button was inserted at the time of total laryngectomy was 86.2%.

  18. Fabrication of a custom ocular prosthesis

    Directory of Open Access Journals (Sweden)

    Tania Sethi

    2014-01-01

    Full Text Available Defects of the eye may follow removal of a part of or the entire orbit. This results in the patient becoming visually, esthetically and psychologically handicapped. Restoring the defect with a silicone- or acrylic-based prosthesis not only restores esthetics but also gives back the lost confidence to the patient. This is a case report of a patient with a `pthisical eye` and details the steps in fabrication of an ocular prosthesis. Particular attention has been given to the laboratory process in this technique to minimize the residual monomer content in the artificial eye.

  19. Capitate pyrocarbon prosthesis in radiocarpal osteoarthritis.

    Science.gov (United States)

    Goubier, Jean-Noël; Vogels, Jérome; Teboul, Frédéric

    2011-03-01

    Scapholunate dissociation or scaphoid pseudarthrosis may lead to osteoarthritis of the wrist. When osteoarthritis affects the midcarpal joint, proximal row carpectomy is no longer possible and only 4 corners fusion or capitolunate arthrodesis may be indicated. However, in some cases, osteoarthritis or bone necrosis may involve the lunatum, making partial arthrodeses impossible. Total arthrodesis may be proposed in such cases, but with a loss of range-of-motion. Total prosthesis may be considered but the results of this procedure are not always encouraging. Consequently, in these situations, we perform pyrocarbon prosthesis implant, replacing the head of the capitatum. This article describes the procedure and the results of a preliminary study.

  20. Synthesis, Chemistry, and Applications of Heterocyclic Cage Compounds (V)

    Institute of Scientific and Technical Information of China (English)

    WU; Hsien-Jen

    2001-01-01

    The synthesis and chemistry of polycyclic of cage compounds have attracted considerable attention in recent years. The vast majority of the work reported in this area has dealt with carbocylic cage compounds. On the other hand, the synthesis and chemistry of heterocyclic cage compounds have received less attention. Recently, we envisioned that studies on the synthesis and chemistry of heterocyclic cage compounds can greatly expand the scopes and utilities of cage compounds.1 As part of a program that involves the synthesis, chemistry, and application of heterocyclic cage compounds, we report here the synthesis of new thia-oxa-cage compounds and the chemical nature of these thia-cages.  ……

  1. High-throughput Transcriptome analysis, CAGE and beyond

    KAUST Repository

    Kodzius, Rimantas

    2008-11-25

    1. Current research - PhD work on discovery of new allergens - Postdoctoral work on Transcriptional Start Sites a) Tag based technologies allow higher throughput b) CAGE technology to define promoters c) CAGE data analysis to understand Transcription - Wo

  2. A caged substrate peptide for matrix metalloproteinases.

    Science.gov (United States)

    Decaneto, Elena; Abbruzzetti, Stefania; Heise, Inge; Lubitz, Wolfgang; Viappiani, Cristiano; Knipp, Markus

    2015-02-01

    Based on the widely applied fluorogenic peptide FS-6 (Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2; Mca = methoxycoumarin-4-acetyl; Dpa = N-3-(2,4-dinitrophenyl)l-α,β-diaminopropionyl) a caged substrate peptide Ac-Lys-Pro-Leu-Gly-Lys*-Lys-Ala-Arg-NH2 (*, position of the cage group) for matrix metalloproteinases was synthesized and characterized. The synthesis implies the modification of a carbamidated lysine side-chain amine with a photocleavable 2-nitrobenzyl group. Mass spectrometry upon UV irradiation demonstrated the complete photolytic cleavage of the protecting group. Time-resolved laser-flash photolysis at 355 nm in combination with transient absorption spectroscopy determined the biphasic decomposition with τa = 171 ± 3 ms (79%) and τb = 2.9 ± 0.2 ms (21%) at pH 6.0 of the photo induced release of the 2-nitrobenzyl group. The recombinantly expressed catalytic domain of human membrane type I matrix metalloproteinase (MT1-MMP or MMP-14) was used to determine the hydrolysis efficiency of the caged peptide before and after photolysis. It turned out that the cage group sufficiently shields the peptide from peptidase activity, which can be thus controlled by UV light.

  3. Resonance spectra of caged black holes

    CERN Document Server

    Hod, Shahar

    2014-01-01

    Recent numerical studies of the coupled Einstein-Klein-Gordon system in a cavity have provided compelling evidence that {\\it confined} scalar fields generically collapse to form black holes. Motivated by this intriguing discovery, we here use analytical tools in order to study the characteristic resonance spectra of the confined fields. These discrete resonant frequencies are expected to dominate the late-time dynamics of the coupled black-hole-field-cage system. We consider caged Reissner-Nordstr\\"om black holes whose confining mirrors are placed in the near-horizon region $x_{\\text{m}}\\equiv (r_{\\text{m}}-r_+)/r_+\\ll\\tau\\equiv (r_+-r_-)/r_+$ (here $r_{\\text{m}}$ is the radius of the confining mirror and $r_{\\pm}$ are the radii of the black-hole horizons). We obtain a simple analytical expression for the fundamental quasinormal resonances of the coupled black-hole-field-cage system: $\\omega_n=-i2\\pi T_{\\text{BH}}\\cdot n[1+O(x^n_{\\text{m}}/\\tau^n)]$, where $T_{\\text{BH}}$ is the temperature of the caged black...

  4. Systemic listeriosis in caged Canaries (Serinus canarius)

    OpenAIRE

    Akanbi, Olatunde B; Breithaupt, Angele; Polster, Ulf; Alter, Thomas; Quandt, Anette; Bracke, Andreas; Teifke, Jens Peter

    2009-01-01

    Abstract The occurrence of listeriosis in 12 caged canaries is described where 50 % of the birds including the female and all the offspring died within two weeks without clinical signs. At necropsy, multifocal necrotising and partly granulomatous hepatitis, splenitis, myocarditis, interstitial nephritis, and exudative pericarditis with intralesional Listeria monocytogenes were the predominant findings as shown by histopathology and immunohistochemistry. Microbiology, serology ...

  5. Geomechanics of fracture caging in wellbores

    NARCIS (Netherlands)

    Weijermars, R.; Zhang, X.; Schultz-Ela, D.

    2013-01-01

    This study highlights the occurrence of so-called ‘fracture cages’ around underbalanced wellbores, where fractures cannot propagate outwards due to unfavourable principal stress orientations. The existence of such cages is demonstrated here by independent analytical and numerical methods. We explain

  6. Resonance spectra of caged black holes

    Energy Technology Data Exchange (ETDEWEB)

    Hod, Shahar [The Ruppin Academic Center, Emeq Hefer (Israel); The Hadassah Institute, Jerusalem (Israel)

    2014-11-15

    Recent numerical studies of the coupled Einstein-Klein-Gordon system in a cavity have provided compelling evidence that confined scalar fields generically collapse to form black holes. Motivated by this intriguing discovery, we here use analytical tools in order to study the characteristic resonance spectra of the confined fields. These discrete resonant frequencies are expected to dominate the late-time dynamics of the coupled black-hole-field-cage system. We consider caged Reissner-Nordstroem black holes whose confining mirrors are placed in the near-horizon region x{sub m} ≡ (r{sub m} - r{sub +})/r{sub +} << τ ≡ (r{sub +} - r{sub -})/r{sub +} (here r{sub m} is the radius of the confining mirror and r{sub ±} are the radii of the black-hole horizons). We obtain a simple analytical expression for the fundamental quasinormal resonances of the coupled blackhole- field-cage system: ω{sub n} = -2πT{sub BH}.n [1 + O(x{sub m}{sup n}/τ{sup n})], where T{sub BH} is the temperature of the caged black hole and n = 1, 2, 3,.. is the resonance parameter. (orig.)

  7. Functional detection of proteins by caged aptamers.

    Science.gov (United States)

    Pinto, Alessandro; Lennarz, Sabine; Rodrigues-Correia, Alexandre; Heckel, Alexander; O'Sullivan, Ciara K; Mayer, Günter

    2012-02-17

    While many diagnostic assay platforms enable the measurement of analytes with high sensitivity, most of them result in a disruption of the analyte's native structure and, thus, in loss of function. Consequently, the analyte can be used neither for further analytical assessment nor functional analysis. Herein we report the use of caged aptamers as templates during apta-PCR analysis of targets. Aptamers are short nucleic acids that fold into a well-defined three-dimensional structure in which they interact with target molecules with high affinity and specificity. Nucleic acid aptamers can also serve as templates for qPCR approaches and, thus, have been used as high affinity ligands to bind to target molecules and subsequently for quantification by qPCR, an assay format coined apta-PCR. Caged aptamers in turn refer to variants that bear one or more photolabile groups at strategic positions. The activity of caged aptamers can thus be turned on or off by light irradiation. The latter allows the mild elution of target-bound aptamers while the target's native structure and function remain intact. We demonstrate that this approach allows the quantitative and subsequently the functional assessment of analytes. Since caged aptamers can be generated emanating from virtually every available aptamer, the described approach can be generalized and adopted to any target-aptamer pair and, thus, have a broad applicability in proteomics and clinical diagnostics.

  8. Busting out of the Teacher Cage

    Science.gov (United States)

    Hess, Frederick M.

    2015-01-01

    The author lays out guidelines and suggestions for how teachers can actually become policy leaders, taken from his book, "The Cage-Busting Teacher" (Harvard Education Press, 2015). Teachers serious about leadership can get the ear of policy makers by leveraging their positional and moral authority--though they may need to be persistent…

  9. Comparison of Range of Motion After Total Knee Prosthesis According to Different Type of Prosthesis

    Directory of Open Access Journals (Sweden)

    Firat Seyfettinoglu

    2016-07-01

    Full Text Available Aim: The aim of this study is to determine the effectiveness and range of motion of different type of knee prosthesis. Material and Method: This study includes 180 of 225 patients (139 F, 41 M, average age: 65, range of age: 51-82 between April 2005 and September 2007 with the diagnosis of gonarthrosis. All patients underwent to primary total knee arthroplasty. Primary osteoartrhritis is the reason of gonarthrosis. The patients with secondary osteoartrhritis were excluded from the study. All the patients were operated by the same surgical team and rehabilitated after surgery. Patella didnt change any patient. PCL was protected in some of the patients and cut some of patients. Totally seven type prosthesis in 16 subgroup were applied to the patients. All measurement were done by the same surgeon. Average follow up period was 31 months (24-49 months. Results: Patients without subgrouping were tested according to the range of motion before and after surgery to the type of the prosthesis trademark. Range of motion was decreased with the usage of Rotaglide and LCS® type of prosthesis. Range of motion didnt change with the usage of Maxim and Kinemax type. The range of motion increased in the other trademark of prosthesis. Flexion angle was increased statistically significant with nexgen® and scorpio® prosthesis (p

  10. 48 CFR 204.7202-1 - CAGE codes.

    Science.gov (United States)

    2010-10-01

    ...) DLIS assigns or records and maintains CAGE codes to identify commercial and Government entities. DoD....39-M, Federal Logistics Information System (FLIS) Procedures Manual, prescribe use of CAGE codes. (b... the provision at 252.204-7001, Commercial and Government Entity (CAGE) Code Reporting, use...

  11. Simplified, low cost below-knee prosthesis.

    Science.gov (United States)

    Kijkusol, D

    1986-08-01

    Problems are encountered in using standard prostheses in developing countries, especially when the prostheses need repair and the amputees cannot come back to the workshop. Very simple, low cost and durable prostheses can solve this problem. The solution described has worked well with villagers in some rural areas of Thailand, where the inexpensive prosthesis permits walking bare-foot and through water and mud.

  12. Prosthesis fabrication using electrical discharge machining.

    Science.gov (United States)

    Van Roekel, N B

    1992-01-01

    Fixed-removable implant prostheses provide solutions for some of the problems associated with implant dentistry, especially in the maxilla. The technique for using electrical discharge machining to create a precise passive fit between the substructure bar and the removable suprastructure is presented. The advantages, disadvantages, and complications associated with this type of prosthesis are discussed.

  13. Movement Control of a Prosthesis Forefinger

    Directory of Open Access Journals (Sweden)

    CHIVU, C.

    2007-04-01

    Full Text Available The present paper approaches the problem of hand prostheses. Designing of hand prostheses implies the use of many types of mechanisms. One of them is the anti-quadrilateral mechanism. The control method chosen and presented in this paper is fuzzy method, applied to a dc motor that actuates each finger of the prosthesis.

  14. Catastrophic failure of a monolithic zirconia prosthesis.

    Science.gov (United States)

    Chang, Jae-Seung; Ji, Woon; Choi, Chang-Hoon; Kim, Sunjai

    2015-02-01

    Recently, monolithic zirconia restorations have received attention as an alternative to zirconia veneered with feldspathic porcelain to eliminate chipping failures of veneer ceramics. In this clinical report, a patient with mandibular edentulism received 4 dental implants in the interforaminal area, and a screw-retained monolithic zirconia prosthesis was fabricated. The patient also received a maxillary complete removable dental prosthesis over 4 anterior roots. At the 18-month follow-up, all of the zirconia cylinders were seen to be fractured, and the contacting abutment surfaces had lost structural integrity. The damaged abutments were replaced with new abutments, and a new prosthesis was delivered with a computer-assisted design and computer-assisted manufacturing fabricated titanium framework with denture teeth and denture base resins. At the 6-month recall, the patient did not have any problems. Dental zirconia has excellent physical properties; however, care should be taken to prevent excessive stresses on the zirconia cylinders when a screw-retained zirconia restoration is planned as a definitive prosthesis.

  15. Argus II retinal prosthesis system: An update.

    Science.gov (United States)

    Rachitskaya, Aleksandra V; Yuan, Alex

    2016-09-01

    This review focuses on a description of the Argus II retinal prosthesis system (Argus II; Second Sight Medical Products, Sylmar, CA) that was approved for humanitarian use by the FDA in 2013 in patients with retinitis pigmentosa with bare or no light perception vision. The article describes the components of Argus II, the studies on the implant, and future directions.

  16. Clinical Outcomes of Penile Prosthesis Implantation Surgery

    Directory of Open Access Journals (Sweden)

    Onur Dede

    2016-06-01

    Full Text Available Objective: We aimed to evaluating the outcomes of in­flatable penile prosthesis implantations and partner sat­isfaction. Methods: Data of 52 patients who underwent penile prosthesis implantation in single center between May 2010 and December 2015 were retrospectively analyzed. Types of prosthesis, complication and satisfaction rates of patients were recorded by EDITS (Erectile Dysfunction Inventory of Treatment Satisfaction questionnaire was used. Results: The mean age was 49.2±14.7 years for patients. The mean follow-up durations for 34.3±12.5 months. The mean hospital stay was 3.84±1.52 days. Evaluating of the couples satisfaction revealed that 44 (84% of the patient were very satisfied. There was not any complication and no patient need to underwent revision surgery. Conclusion: Inflatable penile prosthesis implants, with high levels of treatment success, patient and partner sat­isfaction, are effective and safe options for treatment of organic erectile dysfunction with acceptable complication and revision rates.

  17. Reading visual braille with a retinal prosthesis.

    Science.gov (United States)

    Lauritzen, Thomas Z; Harris, Jordan; Mohand-Said, Saddek; Sahel, Jose A; Dorn, Jessy D; McClure, Kelly; Greenberg, Robert J

    2012-01-01

    Retinal prostheses, which restore partial vision to patients blinded by outer retinal degeneration, are currently in clinical trial. The Argus II retinal prosthesis system was recently awarded CE approval for commercial use in Europe. While retinal prosthesis users have achieved remarkable visual improvement to the point of reading letters and short sentences, the reading process is still fairly cumbersome. This study investigates the possibility of using an epiretinal prosthesis to stimulate visual braille as a sensory substitution for reading written letters and words. The Argus II retinal prosthesis system, used in this study, includes a 10 × 6 electrode array implanted epiretinally, a tiny video camera mounted on a pair of glasses, and a wearable computer that processes the video and determines the stimulation current of each electrode in real time. In the braille reading system, individual letters are created by a subset of dots from a 3 by 2 array of six dots. For the visual braille experiment, a grid of six electrodes was chosen out of the 10 × 6 Argus II array. Groups of these electrodes were then directly stimulated (bypassing the camera) to create visual percepts of individual braille letters. Experiments were performed in a single subject. Single letters were stimulated in an alternative forced choice (AFC) paradigm, and short 2-4-letter words were stimulated (one letter at a time) in an open-choice reading paradigm. The subject correctly identified 89% of single letters, 80% of 2-letter, 60% of 3-letter, and 70% of 4-letter words. This work suggests that text can successfully be stimulated and read as visual braille in retinal prosthesis patients.

  18. Reading visual Braille with a retinal prosthesis

    Directory of Open Access Journals (Sweden)

    Thomas Zaccarin Lauritzen

    2012-11-01

    Full Text Available Retinal prostheses, which restore partial vision to patients blinded by outer retinal degeneration, are currently in clinical trial. The Argus II retinal prosthesis system was recently awarded CE approval for commercial use in Europe. While retinal prosthesis users have achieved remarkable visual improvement to the point of reading letters and short sentences, the reading process is still fairly cumbersome. This study investigates the possibility of using an epiretinal prosthesis to stimulate visual Braille as a sensory substitution for reading written letters and words. The Argus II retinal prosthesis system, used in this study, includes a 10 x 6 electrode array implanted epiretinally, a tiny video camera mounted on a pair of glasses, and a wearable computer that processes the video and determines the stimulation current of each electrode in real time. In the Braille reading system, individual letters are created by a subset of dots from a 3 by 2 array of six dots. For the visual Braille experiment, a grid of six electrodes was chosen out of the 10 x 6 Argus II array. Groups of these electrodes were then directly stimulated (bypassing the camera to create visual percepts of individual Braille letters. Experiments were performed in a single subject. Single letters were stimulated in an alternative forced choice (AFC paradigm, and short 2-4-letter words were stimulated (one letter at a time in an open-choice reading paradigm. The subject correctly identified 89% of single letters, 80% of 2-letter, 60% of 3-letter, and 70% of 4-letter words. This work suggests that text can successfully be stimulated and read as visual Braille in retinal prosthesis patients.

  19. Multielectrode machine for making the cages of bag filters

    Energy Technology Data Exchange (ETDEWEB)

    Gordeev, F.I.; Arkov, V.G.; Boldyrev, A.F.; Sharenko, D.G.; Zhidkov, V.A.

    1986-01-01

    This paper describes an automatic multielectrode machine for making wire cages with an internal spiral. The machine automatically produces an endless cage from wire, joins the wires by multiple spot contact welding, and cuts it into pieces of desired length. The machine is illustrated and the method of making wire cages is demonstrated. The cages are used in bag filters of gas-cleaning systems. The machine can be used to form cages of 130-mm diameter from wires of 3-mm diameter. It is easy to operate and has a high output rate of 90m/h.

  20. On metallic clusters squeezed in atomic cages

    CERN Document Server

    Apostol, M

    1996-01-01

    The stability of metallic clusters of sodium (Na) in the octahedral cages of Na-doped fullerites Na6C60 and Na11C60 is discussed within a Thomas-Fermi model. It is shown that the tetrahedral Na4-cluster in Na6C60 has an electric charge of cca. +2.7 (in electron charge units), while the body-centered cubic Na9-cluster in Na11C60 is almost electrically neutral.

  1. Cathodic Cage Plasma Nitriding: An Innovative Technique

    OpenAIRE

    Sousa,R.R.M.; de Araújo, F. O.; J. A. P. da Costa; Brandim,A.S.; R. A. de Brito; C. Alves

    2012-01-01

    Cylindrical samples of AISI 1020, AISI 316, and AISI 420 steels, with different heights, were simultaneously treated by a new technique of ionic nitriding, entitled cathodic cage plasma nitriding (CCPN), in order to evaluate the efficiency of this technique to produce nitrided layers with better properties compared with those obtained using conventional ionic nitriding technique. This method is able to eliminate the edge effect in the samples, promoting a better uniformity of temperature, and...

  2. Development and clinical application of a new testicular prosthesis

    Institute of Scientific and Technical Information of China (English)

    Ye Ning; Zhikang Cai; Huixing Chen; Ping Ping; Peng Li; Zhong Wang; Zheng Li

    2011-01-01

    A new type of testicular prosthesis made of silastic with an elliptical shape to mimic a normal testis was developed by our team and submitted for patenting in China.The prosthesis was produced in different sizes to imitate the normal testis of the patient.To investigate the effects and safety of the testicular prosthesis,20 patients receiving testicular prosthesis implantation were recruited for this study.Follow-up after 6 months revealed no complications in the patients.All the patients answered that they were satisfied with their body image and the position of the implants,19 patients were satisfied with the size and 16 patients were satisfied with the weight.These results show that the testicular prosthesis used in this study can meet patient's expectations.Patients undergoing orchiectomy should be offered the option to receive a testicular prosthesis implantation.The dimensions and weight of the available prosthetic implants should be further addressed to improve patient satisfaction.

  3. Design and Control of a Powered Transfemoral Prosthesis.

    Science.gov (United States)

    Sup, Frank; Bohara, Amit; Goldfarb, Michael

    2008-02-01

    The paper describes the design and control of a transfemoral prosthesis with powered knee and ankle joints. The initial prototype is a pneumatically actuated powered-tethered device, which is intended to serve as a laboratory test bed for a subsequent self-powered version. The prosthesis design is described, including its kinematic optimization and the design of a three-axis socket load cell that measures the forces and moments of interaction between the socket and prosthesis. A gait controller is proposed based on the use of passive impedance functions that coordinates the motion of the prosthesis with the user during level walking. The control approach is implemented on the prosthesis prototype and experimental results are shown that demonstrate the promise of the active prosthesis and control approach in restoring fully powered level walking to the user.

  4. Tracheobronchial Foreign Body Aspiration: Dental Prosthesis

    Directory of Open Access Journals (Sweden)

    Ataman Köse

    2014-01-01

    Full Text Available It is important to extract foreign bodies for avoiding life-threatening complications. They can lead to death if they are not treated. Different signs and symptoms could occur according to the complete or partial airway obstruction. Foreign body aspiration is a rare incident in adults. The organic foreign materials such as foods are found to be aspirated more commonly and are usually settled in the right bronchial system. However, dental prosthesis and teeth aspirations are rare in literature. In our study, a 52-year-old male patient who had aspirated the front part of his lower dental prosthesis accidentally is presented and the foreign body is extracted by using rigid bronchoscopy. There are many causes of aspiration but dental prosthetic aspirations should be kept in mind during sleep. For this reason, dental apparatus must be taken out while asleep.

  5. Design and Control of a Powered Transfemoral Prosthesis

    OpenAIRE

    Sup, Frank; Bohara, Amit; Goldfarb, Michael

    2008-01-01

    The paper describes the design and control of a transfemoral prosthesis with powered knee and ankle joints. The initial prototype is a pneumatically actuated powered-tethered device, which is intended to serve as a laboratory test bed for a subsequent self-powered version. The prosthesis design is described, including its kinematic optimization and the design of a three-axis socket load cell that measures the forces and moments of interaction between the socket and prosthesis. A gait controll...

  6. Correlation analysis between the interface membrane and loose hip prosthesis

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Objective To analyze the cause of prosthesis loosening by observing the interface membranes harvested during the hip restoration operation. Methods A total of 28 specimens of interface membrane around the loose prosthesis were harvested from 28 patients undergoing the restoration of total hip replacement. All the specimens underwent the observation of appearance, light microscopy and scanning electronic microscopy(SEM). Results All the gaps around the loose prosthesis were filled with interface membrane of ...

  7. Dental prosthesis and buccal lesions in the elderly

    OpenAIRE

    Beatriz García Alpizar; Mikhail Benet Rodíguez; Eduardo Enrique Castillo Betancourt

    2010-01-01

    Fundament: Buccal lesions in the elderly are very frequent and they constitute a problem of health due to the consequences that cause. Objective: to describe the characteristics of the removable prosthesis used by the population of 60 and more years age and their relationship with the lesions of the oral mucosa. Methods: We carried out a study descriptive of cross section in 125 elderly with oral prosthesis. The characteristics of the removable prosthesis were described and their relationship...

  8. Ischemic Gangrene of the Glans following Penile Prosthesis Implantation

    OpenAIRE

    Borja García Gómez; Javier Romero Otero; Laura Díez Sicilia; Estibaliz Jiménez Alcaide; Eduardo García-Cruz; Alfredo Rodríguez Antolín

    2013-01-01

    The development of ischemic gangrene of the penis following implantation of prosthesis is unusual, and very few cases are available in the literature. As a result, no established treatment protocol is available. We report our experience within a case of gangrene of the glans following implantation of a three-component prosthesis. We present a 53-year-old male, smoker with diabetes and hypercholesterolemia, who underwent surgery for the insertion of a penile prosthesis with 3 components to cor...

  9. Control of dental prosthesis system with microcontroller.

    Science.gov (United States)

    Kapidere, M; Müldür, S; Güler, I

    2000-04-01

    In this study, a microcontroller-based electronic circuit was designed and implemented for dental prosthesis curing system. Heater, compressor and valve were controlled by 8-bit PIC16C64 microcontroller which is programmed using MPASM package. The temperature and time were controlled automatically by preset values which were inputted from keyboard while the pressure was kept constant. Calibration was controlled and the working range was tested. The test results showed that the system provided a good performance.

  10. Orofacial Space Infection Due to Faulty Prosthesis

    OpenAIRE

    Pramod Krishna, B.; Batra, Ranmeet; Chopra, Sumit; Sethi, Nitin

    2011-01-01

    Orofacial space infections are commonly treated by oral and maxillofacial surgeons, even in the post antibiotic era. Pre existing systemic conditions such as diabetes mellitus makes a person more vulnerable to space infection. A prosthesis which is poorly designed often jeopardises the oral health and makes a person susceptible to ulcers of mucosa, which can result in necrosis of mucosa. The sequel of such ulcerations and necrosis would be life threatening Orofacial space infections in medica...

  11. Gingival prosthesis: A treatment modality for recession

    Directory of Open Access Journals (Sweden)

    Pallavi Samatha Yalamanchili

    2013-01-01

    Full Text Available Gingival recession caused due to periodontal disease disturbs patients because of sensitivity and esthetics. Gingival prosthesis may be fixed or removable and can be made from silicones, acrylics, composite resins or ceramics according to what is best suited for the case. The gingival veneer is esthetically appealing and easy to maintain. This case report describes the use of gingival veneer as a treatment modality for recession.

  12. Gingival prosthesis: A treatment modality for recession

    OpenAIRE

    Pallavi Samatha Yalamanchili; Hemchand Surapaneni; Arunima Padmakumar Reshmarani

    2013-01-01

    Gingival recession caused due to periodontal disease disturbs patients because of sensitivity and esthetics. Gingival prosthesis may be fixed or removable and can be made from silicones, acrylics, composite resins or ceramics according to what is best suited for the case. The gingival veneer is esthetically appealing and easy to maintain. This case report describes the use of gingival veneer as a treatment modality for recession.

  13. Adsorption. Cage molecules to pick up the pollutants; Adsorption. Des molecules cages pour capter les polluants

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1999-12-01

    The cyclo-dextrins have the property to be cage molecules, that is to say they are able to shut up organic molecules in their structure. To use them in remedial action against pollution it is necessary to find a support on which they can be grafted. The Laboratory of organic chemistry and macromolecules from the University of Sciences and Technologies of Lilles is looking for this. The researchers have used a textile material in non weaved polypropylene, a support chemically steady that resists to aggressive media such polluted effluents. To graft the cage molecule, the technique of electrons bombing has been chosen. It produces a monomer (methacrylate of glycidyl) that allows to have a tissue bearer of epoxide functions susceptible to react with the cyclo-dextrin. The studies are continued in particular to valid the use of cage molecules on the dioxin and pesticides, and also to adapt the filter to gaseous media (volatile organic compounds, smells). (N.C.)

  14. A Method to Analyze Dynamics Properties of Transfemoral Prosthesis

    Directory of Open Access Journals (Sweden)

    Van Tuan Le

    2016-01-01

    Full Text Available Abstract.The methodto compute gait cycle forces and moments acting on the hip and knee joints of a lower limb with a trans-femoral prosthesis were investigated. A 3D model of the lower limb with prosthesis was created using CAD software and based on MRI data and real size dimension. The transfemoral prosthesis was modelled as a coupled of links with two revolution joints at hip and knee joint. This coupled link was connected to a bar with translation joint to description the distance walked of people in gait cycle. All parts of the prosthesis were measured and a full-size 3D model was created.The kinematics parameters of a lower limb with a prosthesis were determined from motion-captured system data. The reaction force was measured with a force sensor in the footplate. The 3D model of the prosthesis was exported to MatlabSimmechanics. The input data which are kinematic parameters were applied to calculate the forces and moments acting on the joints. The results of this study present a method to analyse the dynamic properties of transfemoral prosthesis including speed of the gait. It could be used to calculate the load transferred from the socket to the residual limb. They could also be used to design the structure of a prosthesis and optimize the dynamic characteristics of such a prosthesis.

  15. Development of Receiver Stimulator for Auditory Prosthesis

    Directory of Open Access Journals (Sweden)

    K. Raja Kumar

    2010-05-01

    Full Text Available The Auditory Prosthesis (AP is an electronic device that can provide hearing sensations to people who are profoundly deaf by stimulating the auditory nerve via an array of electrodes with an electric current allowing them to understand the speech. The AP system consists of two hardware functional units such as Body Worn Speech Processor (BWSP and Receiver Stimulator. The prototype model of Receiver Stimulator for Auditory Prosthesis (RSAP consists of Speech Data Decoder, DAC, ADC, constant current generator, electrode selection logic, switch matrix and simulated electrode resistance array. The laboratory model of speech processor is designed to implement the Continuous Interleaved Sampling (CIS speech processing algorithm which generates the information required for electrode stimulation based on the speech / audio data. Speech Data Decoder receives the encoded speech data via an inductive RF transcutaneous link from speech processor. Twelve channels of auditory Prosthesis with selectable eight electrodes for stimulation of simulated electrode resistance array are used for testing. The RSAP is validated by using the test data generated by the laboratory prototype of speech processor. The experimental results are obtained from specific speech/sound tests using a high-speed data acquisition system and found satisfactory.

  16. Modular Tumor Resection Prosthesis in Osteosarcoma Treatment

    Directory of Open Access Journals (Sweden)

    Alper Cirakli

    2016-07-01

    Full Text Available Aim: The aim of the study is to evaluate the cases who underwent tumor resection prosthesis due to osteosarcoma. Material and Method: 14 cases who underwent tumor resection prosthesis due to osteosarcoma in our clinic between 2000 and 2012 and who had sufficient follow-ups were evaluated. The cases were examined in terms of gender, age, direction, tumor location, follow-up time, success of the treatment, complication, recurrence, and survival. The data obtained were transferred to the SPSS 15.0 program and analyzed. Normality distributions of the data were analyzed with the Shapiro-Wilk test. Results: 8 of the 14 cases were male, 6 were female, and the average age of the cases was 21.9±7.02. Osteosarcoma was in the distal femur in 9 (64.3% of the patients, in the proximal tibia in 5 (35.7% of the patients, in the right lower extremity in 5 of the patients, and in the left lower extremity in 9 of the patients. Average follow-up time was 33 months (3-144 months range. Average MSTS score was found as 81.9 (53-96 range, perfect results were taken in 11 (78.6% patients while insufficient results were taken in 3 (21.4% patients. As for complications, aseptic softening was observed in 3 cases, peroneal nerve paralysis was observed in 2 cases, skin necrosis was observed in 2 cases, periprostatic fracture was observed in 2 cases, prosthesis infection was observed in 1 case, and local recurrence was observed in 1 case. Except for the two cases with peroneal nerve paralysis, cases with complications recovered without any problems. The patient who developed local recurrence was lost due to lung metastasis. Discussion: Treatment of osteosarcoma through tumor resection prosthesis raises question marks due to possible complications that can affect the survival of the prosthesis in the long term. However, this treatment method is favorable in terms of stability, early load efficiency, and causing less anxiety than osteosynthesis; it is also psychologically

  17. Multi-responsive metal-organic lantern cages in solution.

    Science.gov (United States)

    Brega, Valentina; Zeller, Matthias; He, Yufan; Lu, H Peter; Klosterman, Jeremy K

    2015-03-25

    Soluble copper-based M4L4 lantern-type metal-organic cages bearing internal amines were synthesized. The solution state integrity of the paramagnetic metal-organic cages was demonstrated using NMR, DLS, MS, and AFM spectroscopy. 1D supramolecular pillars of pre-formed cages or covalent host-guest complexes selectively formed upon treatment with 4,4'-bipyridine and acetic anhydride, respectively.

  18. Systemic listeriosis in caged canaries (Serinus canarius).

    Science.gov (United States)

    Akanbi, Olatunde B; Breithaupt, Angele; Polster, Ulf; Alter, Thomas; Quandt, Anette; Bracke, Andreas; Teifke, Jens P

    2008-06-01

    The occurrence of listeriosis in 12 caged canaries is described where 50% of the birds, including the female and all of the offspring, died within 2 weeks without clinical signs. At necropsy, multifocal necrotizing and partly granulomatous hepatitis, splenitis, myocarditis, interstitial nephritis, and exudative pericarditis with intra-lesional Listeria monocytogenes were the predominant findings as shown by histopathology and immunohistochemistry. Microbiology, serology and polymerase chain reaction revealed L. monocytogenes serotype 1/2a as the causative agent. Thus listeriosis has to be considered in the differential diagnosis for granulomas associated with mycobacteriosis, yersiniosis, coligranulomatosis or fungal infections.

  19. Genetic encoding of caged cysteine and caged homocysteine in bacterial and mammalian cells.

    Science.gov (United States)

    Uprety, Rajendra; Luo, Ji; Liu, Jihe; Naro, Yuta; Samanta, Subhas; Deiters, Alexander

    2014-08-18

    We report the genetic incorporation of caged cysteine and caged homocysteine into proteins in bacterial and mammalian cells. The genetic code of these cells was expanded with an engineered pyrrolysine tRNA/tRNA synthetase pair that accepts both light-activatable amino acids as substrates. Incorporation was validated by reporter assays, western blots, and mass spectrometry, and differences in incorporation efficiency were explained by molecular modeling of synthetase-amino acid interactions. As a proof-of-principle application, the genetic replacement of an active-site cysteine residue with a caged cysteine residue in Renilla luciferase led to a complete loss of enzyme activity; however, upon brief exposure to UV light, a >150-fold increase in enzymatic activity was observed, thus showcasing the applicability of the caged cysteine in live human cells. A simultaneously conducted genetic replacement with homocysteine yielded an enzyme with greatly reduced activity, thereby demonstrating the precise probing of a protein active site. These discoveries provide a new tool for the optochemical control of protein function in mammalian cells and expand the set of genetically encoded unnatural amino acids.

  20. Effect of cage configuration in structural and optical properties of tin films grown by cathodic cage discharge

    Directory of Open Access Journals (Sweden)

    Natália de Freitas Daudt

    2013-01-01

    Full Text Available Cathodic cage discharge was developed recently in order to eliminate phenomena as edge effect and overheating, which occurs during conventional processes. In this study, the effect of cage configuration in active species during the deposition process and optical properties of TiN film were studied. TiN compound was chosen because its optical properties are very sensitive to slight variations in microstructure and film thickness, becoming a good monitoring tool in fabrication process control. Cages were made of titanium and have different holes numbers and holes diameter. Electrical efficiency of the system and optical properties of TiN films were strongly influenced by experimental conditions. It was found that with more holes at the top of cage, deposition rate and crystallinity were higher, if compared to cages with a small number of holes at the top. On the other hand, the opposite behavior was observed when more holes were located at the sidewall of cage.

  1. Design and wear testing of a temporomandibular joint prosthesis articulation

    NARCIS (Netherlands)

    van Loon, JP; Verkerke, GJ; de Vries, MP; de Bont, LGM

    2000-01-01

    As part of the development of a total temporomandibular joint prosthesis, a prosthesis articulation was designed. The articulation consists of a spherical head (ball) of the mandibular part, rotating against an enveloping ultra-high-molecular-weight polyethylene (UHMWPE) disc with a flat cranial sid

  2. Linking of total elbow prosthesis during surgery; a biomechanical analysis

    NARCIS (Netherlands)

    Vos, M.J. de; Wagener, M.L.; Hendriks, J.C.M.; Eygendaal, D.; Verdonschot, N.J.J.

    2013-01-01

    BACKGROUND: Presently, 2 types of elbow prostheses are used: unlinked and linked. The Latitude total elbow prosthesis allows the surgeon to decide during the implantation whether the prosthesis is placed unlinked or linked, and whether the native radial head is retained, resected, or replaced. The p

  3. Novel knee joint mechanism of transfemoral prosthesis for stair ascent.

    Science.gov (United States)

    Inoue, Koh; Wada, Takahiro; Harada, Ryuchi; Tachiwana, Shinichi

    2013-06-01

    The stability of a transfemoral prosthesis when walking on flat ground has been established by recent advances in knee joint mechanisms and their control methods. It is, however, difficult for users of a transfemoral prosthesis to ascend stairs. This difficulty is mainly due to insufficient generation of extension moment around the knee joint of the prosthesis to lift the body to the next step on the staircase and prevent any unexpected flexion of the knee joint in the stance phase. Only a prosthesis with an actuator has facilitated stair ascent using a step-over-step gait (1 foot is placed per step). However, its use has issues associated with the durability, cost, maintenance, and usage environment. Therefore, the purpose of this research is to develop a novel knee joint mechanism for a prosthesis that generates an extension moment around the knee joint in the stance phase during stair ascent, without the use of any actuators. The proposed mechanism is based on the knowledge that the ground reaction force increases during the stance phase when the knee flexion occurs. Stair ascent experiments with the prosthesis showed that the proposed prosthesis can realize stair ascent without any undesirable knee flexion. In addition, the prosthesis is able to generate a positive knee joint moment power in the stance phase even without any power source.

  4. 21 CFR 878.3750 - External prosthesis adhesive.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false External prosthesis adhesive. 878.3750 Section 878.3750 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... adhesive. (a) Identification. An external prosthesis adhesive is a silicone-type adhesive intended to...

  5. Preinjector for Linac 1, Faraday cage

    CERN Multimedia

    1974-01-01

    The 50 MeV Linac 1 started up in 1958 as injector to the 26 GeV PS, with a 520 kV Cockcroft-Walton generator as its preinjector, housed in a vast Faraday cage, visible here. When the Cockcroft-Walton broke down in 1973, it was replaced by a much smaller SAMES generator, of the kind used for electrostatic separators. From 1980 on, Linac 2 took over as injector for the 800 MeV Booster, and Linac 1 continued as injector for LEAR. In 1984, the electrostatic preinjector (i.e. the Faraday cage with its contents, SAMES generator and all) was replaced by a 520 keV RFQ. At the lower left corner we see the HV connectors to the SAMES generator, at the right edge part of the opened electronics-platform. Jean-Luc Vallet sees to it that all parts are properly grounded. See also 7403073X, 7403074X, 7403081X, 7403083X.

  6. Amputation and prosthesis implantation shape body and peripersonal space representations.

    Science.gov (United States)

    Canzoneri, Elisa; Marzolla, Marilena; Amoresano, Amedeo; Verni, Gennaro; Serino, Andrea

    2013-10-03

    Little is known about whether and how multimodal representations of the body (BRs) and of the space around the body (Peripersonal Space, PPS) adapt to amputation and prosthesis implantation. In order to investigate this issue, we tested BR in a group of upper limb amputees by means of a tactile distance perception task and PPS by means of an audio-tactile interaction task. Subjects performed the tasks with stimulation either on the healthy limb or the stump of the amputated limb, while wearing or not wearing their prosthesis. When patients performed the tasks on the amputated limb, without the prosthesis, the perception of arm length shrank, with a concurrent shift of PPS boundaries towards the stump. Conversely, wearing the prosthesis increased the perceived length of the stump and extended the PPS boundaries so as to include the prosthetic hand, such that the prosthesis partially replaced the missing limb.

  7. Penile Corporeal Reconstruction during Difficult Placement of a Penile Prosthesis

    Directory of Open Access Journals (Sweden)

    Viet Q. Tran

    2008-01-01

    Full Text Available For some patients with impotence and concomitant severe tunical/corporeal tissue fibrosis, insertion of a penile prosthesis is the only option to restore erectile function. Closing the tunica over an inflatable penile prosthesis in these patients can be challenging. We review our previous study which included 15 patients with severe corporeal or tunical fibrosis who underwent corporeal reconstruction with autologous rectus fascia to allow placement of an inflatable penile prosthesis. At a mean follow-up of 18 months (range 12 to 64, all patients had a prosthesis that was functioning properly without evidence of separation, herniation, or erosion of the graft. Sexual activity resumed at a mean time of 9 weeks (range 8 to 10. There were no adverse events related to the graft or its harvest. Use of rectus fascia graft for coverage of a tunical defect during a difficult penile prosthesis placement is surgically feasible, safe, and efficacious.

  8. Computed tomography measurement of rib cage morphometry in emphysema.

    Directory of Open Access Journals (Sweden)

    Nicola Sverzellati

    Full Text Available BACKGROUND: Factors determining the shape of the human rib cage are not completely understood. We aimed to quantify the contribution of anthropometric and COPD-related changes to rib cage variability in adult cigarette smokers. METHODS: Rib cage diameters and areas (calculated from the inner surface of the rib cage in 816 smokers with or without COPD, were evaluated at three anatomical levels using computed tomography (CT. CTs were analyzed with software, which allows quantification of total emphysema (emphysema%. The relationship between rib cage measurements and anthropometric factors, lung function indices, and %emphysema were tested using linear regression models. RESULTS: A model that included gender, age, BMI, emphysema%, forced expiratory volume in one second (FEV1%, and forced vital capacity (FVC% fit best with the rib cage measurements (R(2 = 64% for the rib cage area variation at the lower anatomical level. Gender had the biggest impact on rib cage diameter and area (105.3 cm(2; 95% CI: 111.7 to 98.8 for male lower area. Emphysema% was responsible for an increase in size of upper and middle CT areas (up to 5.4 cm(2; 95% CI: 3.0 to 7.8 for an emphysema increase of 5%. Lower rib cage areas decreased as FVC% decreased (5.1 cm(2; 95% CI: 2.5 to 7.6 for 10 percentage points of FVC variation. CONCLUSIONS: This study demonstrates that simple CT measurements can predict rib cage morphometric variability and also highlight relationships between rib cage morphometry and emphysema.

  9. [Aortoenteric fistula secondary to aortobifemoral prosthesis infection].

    Science.gov (United States)

    Gabriel Botella, F; Labiós Gómez, M; Ibáñez Gadea, L; Fácila Rubio, L; Carbonell Cantí, C

    2002-05-01

    We present the case of a 76 year-old man, intervened of an obstruction bilateral iliac by means of placement of a prosthesis aortobifemoral that presented pain in the grave left iliac and fever in needles of 39 degrees C to the five years of the intervention. In the physical exploration it highlighted a painful abdomen in the grave left iliac with signs of peritoneal irritation. In the laboratory tests a leukocytosis was detected with neutrophilia and negative culture. The computed thomography (CT) show the presence of gas bubbles around the prosthesis, as well as a liquid collection with areas necrotics in their interior that affected to the psoas and iliac muscles. In the same exploration the aspirative puncture with drainage of the absces demonstrated in the cultivations carried out in aerobic means the presence of Enterococcus faecalis and Enterobacter cloacae. When presenting a high gastrointestinal hemorrhage abruptly, he was practiced and gastroduodenal endoscope in which a aortoduodenal fistula was evidenced with having bled active. When a bypass extra-anatomic, the sick person will practice it died when presenting a shock abrupt hipovolemic that he didn't respond to the pertinent treatment. We analyze the approaches current diagnoses of infection of the vascular prosthesis and their more serious complication, the aortoenteric fistula (AEF) that either appears in the 0.3-5.9% of the patients who undergo prosthetic reconstruction of the abdominal aorta, for occlusive or aneurismal disease. We highlight the importance of carrying out a precocious diagnosis of the infection of the portion retroperitoneal of the vascular graft that, often, it is manifested with subtle and not specific clinical signs, with the techniques at the moment available as: the CT, fine needle aspiration guided by her, and to diminish the rates of mortality, from the current of 43%, until the most optimistic estimated in 19%.

  10. The Nijdam voice prosthesis: A self-retaining valveless voice prosthesis for vocal rehabilitation after total laryngectomy

    NARCIS (Netherlands)

    Hoogen, F.J.A. van den; Nijdam, H.F.; Veenstra, A.; Manni, J.J.

    1996-01-01

    Voice prosthesis-assisted speech rehabilitation after total laryngectomy has proven to be successful in the majority of patients and exceeds the results of traditional oesophageal speech. Nevertheless 10 -30% failure rates are still reported. in part this is due to prosthesis-related problems, in pa

  11. The Nijdam voice prosthesis : A self-retaining valveless voice prosthesis for vocal rehabilitation after total laryngectomy

    NARCIS (Netherlands)

    van den Hoogen, Frank J. A.; Nijdam, Hoite F.; Veenstra, Aalze; Manni, JJ

    1996-01-01

    Voice prosthesis-assisted speech rehabilitation after total laryngectomy has proven to be successful in the majority of patients and exceeds the results of traditional oesophageal speech. Nevertheless 10-30% failure rates are still reported. In part this is due to prosthesis-related problems, in par

  12. 21 CFR 878.3540 - Silicone gel-filled breast prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Silicone gel-filled breast prosthesis. 878.3540...-filled breast prosthesis. (a) Identification—(1) Single-lumen silicone gel-filled breast prosthesis. A single-lumen silicone gel-filled breast prosthesis is a silicone rubber shell made of...

  13. Abnormal Behavior in Relation to Cage Size in Rhesus Monkeys

    Science.gov (United States)

    Paulk, H. H.; And Others

    1977-01-01

    Examines the effects of cage size on stereotyped and normal locomotion and on other abnormal behaviors in singly caged animals, whether observed abnormal behaviors tend to co-occur, and if the development of an abnormal behavior repertoire leads to reduction in the number of normal behavior categories. (Author/RK)

  14. Teaching in the Institutional Cage: Metaphor and Collateral Oppression

    Science.gov (United States)

    Noël Smith, Becky L.

    2014-01-01

    This analysis is a philosophical exploration of Marilyn Frye's metaphor of the cage and Patricia Hill Collins' theory of intersecting oppressions. It argues that social structures and forms of oppressive knowledge make up the individual wires on each person's cage and that these work to confine individuals, particularly those in the…

  15. Dynamic Combinatorial Libraries of Disulfide Cages in Water

    NARCIS (Netherlands)

    West, Kevin R.; Bake, Kyle D.; Otto, Sijbren

    2005-01-01

    Dynamic combinatorial libraries (DCLs) containing water-soluble disulfide-linked cages (alongside macrocyclic structures) have been generated and characterized. Unlike most other strategies for generating molecular cages, the structures are held together by covalent bonds, which are formed under the

  16. Design of the UHVDC Corona Cage in China

    Institute of Scientific and Technical Information of China (English)

    GUO Jian; LU Jiayu; ZHANG Wenliang

    2013-01-01

    For the purpose of testing and analysing the corona characteristics of UHVDC bundle conductors,UHVDC corona cage would be built in China.Corona cage is one of the indispensable equipments for conductor corona performance researches.Tests of conductor cotona characteristics in corona cages can overcome the shortages of those with test lines.The dimensions of several corona cages constructed overseas were introduced in this paper.Based on foreign experiences and the requirement of State Grid Corporation of China,the UHVDC corona cage was designed as double-cage,double-layer,three-seetions,and catenary shape with the size of 70 m×22 m× 13 m.The corona loss measurement system,radio interference measuring system,and the audible noise measuring system are also detailed,including the measurement theory,connection with the cage,the parameters and the designing basis.The UHVDC corona cage has been put into service.It now undergoes a large amount of audible noise and radio frequency interference tests.

  17. Tehran Silicon Partial Foot Prosthesis New Method of Making Silicon Partial Foot Prosthesis

    Directory of Open Access Journals (Sweden)

    Alireza Khaghani

    2016-12-01

    Full Text Available Partial foot amputation includes many surfaces from severing toe to Chopart amputation, and each surface has its own characteristic and creates a particular level of disability, which would require prosthesis to compensate the missing functionality and aesthetics. On the other hand, with regard to materials and style of structure according to the facilities of clinics and the experience of prosthetists a vast scope of prostheses are made for patients, and practically the process of prescription and Production of a prosthesis is an interaction between the patient and the prosthetist ,based on the needs and expectations of the patient and the ability of prosthetist to reach a point of equilibrium which often requires employing the maximum ability of prosthetist in the construction technique. The resulting diversity is the outcome of successful experiences of various prosthetists over the years, and it is natural that when considering the extent of various materials used in the making of prostheses and also the methods of their synthesis and linkage, and also better understanding of the developed biomechanical disorder, we can achieve new designs that would bring better performance and comfort to patients, as well as more aestheticism in appearance. If the amputation is proximal to the metatarsal heads, the individual will lose tolerance for weight bearing of fore foot and will face difficulty in the terminal stance stage for doing the push-off. For Trans-metatarsal and Lisfranc areas which are considered mid foot area, high profile prosthesis have not been well acceptance by patients because a rigid prosthesis continues till near tibia tuberose and more important than that, creates restriction of movement in ankle and subtalar joints, despite having biomechanical advantages in restoring the lever arm for doing the push off .Perimalleolar prostheses which enjoy great variety with regard to design and material used in their structure, mostly are not

  18. Photoactivatable Caged Prodrugs of VEGFR-2 Kinase Inhibitors

    Directory of Open Access Journals (Sweden)

    Boris Pinchuk

    2016-04-01

    Full Text Available In this study, we report on the design, synthesis, photokinetic properties and in vitro evaluation of photoactivatable caged prodrugs for the receptor tyrosine kinase VEGFR-2. Highly potent VEGFR-2 inhibitors 1 and 3 were caged by introduction of a photoremovable protecting group (PPG to yield the caged prodrugs 4 and 5. As expected, enzymatic and cellular proliferation assays showed dramatically diminished efficacy of caged prodrugs in vitro. Upon ultraviolet (UV irradiation of the prodrugs original inhibitory activity was completely restored and even distinctly reinforced, as was the case for the prodrug 4. The presented results are a further evidence for caging technique being an interesting approach in the protein kinase field. It could enable spatial and temporal control for the inhibition of VEGFR-2. The described photoactivatable prodrugs might be highly useful as biological probes for studying the VEGFR-2 signal transduction.

  19. Organic cage compounds--from shape-persistency to function.

    Science.gov (United States)

    Zhang, Gang; Mastalerz, Michael

    2014-03-21

    Defined cavities are found in biological systems, such as in enzymes to accelerate specific reactions with specific molecular targets, or as transport containers for molecular cargoes. Chemists have been inspired by those phenomena found in nature and synthesized defined cage compounds for different purposes, such as for stabilizing reactive intermediates, running reactions within the cavities or studying recognition events. However, most cage compounds are based on the coordination of metal ions, and only a few are charge neutral. Purely organic cages are usually charge neutral and more stable due to existing covalent bonds. Covalent bonds can be made in two ways, applying irreversible reactions or reversible reactions. By introducing dynamic covalent chemistry (DCC), cages have become accessible in good yields from rather simple precursors. Here, we compare both methods and highlight those that give very good yields. Furthermore, the use of organic cage compounds in sorption, recognition, sensing, separation and stabilization of molecules will be discussed.

  20. Photovoltaic retinal prosthesis with high pixel density

    Science.gov (United States)

    Mathieson, Keith; Loudin, James; Goetz, Georges; Huie, Philip; Wang, Lele; Kamins, Theodore I.; Galambos, Ludwig; Smith, Richard; Harris, James S.; Sher, Alexander; Palanker, Daniel

    2012-06-01

    Retinal degenerative diseases lead to blindness due to loss of the `image capturing' photoreceptors, while neurons in the `image-processing' inner retinal layers are relatively well preserved. Electronic retinal prostheses seek to restore sight by electrically stimulating the surviving neurons. Most implants are powered through inductive coils, requiring complex surgical methods to implant the coil-decoder-cable-array systems that deliver energy to stimulating electrodes via intraocular cables. We present a photovoltaic subretinal prosthesis, in which silicon photodiodes in each pixel receive power and data directly through pulsed near-infrared illumination and electrically stimulate neurons. Stimulation is produced in normal and degenerate rat retinas, with pulse durations of 0.5-4 ms, and threshold peak irradiances of 0.2-10 mW mm-2, two orders of magnitude below the ocular safety limit. Neural responses were elicited by illuminating a single 70 µm bipolar pixel, demonstrating the possibility of a fully integrated photovoltaic retinal prosthesis with high pixel density.

  1. Transcription regulatory networks analysis using CAGE

    KAUST Repository

    Tegnér, Jesper N.

    2009-10-01

    Mapping out cellular networks in general and transcriptional networks in particular has proved to be a bottle-neck hampering our understanding of biological processes. Integrative approaches fusing computational and experimental technologies for decoding transcriptional networks at a high level of resolution is therefore of uttermost importance. Yet, this is challenging since the control of gene expression in eukaryotes is a complex multi-level process influenced by several epigenetic factors and the fine interplay between regulatory proteins and the promoter structure governing the combinatorial regulation of gene expression. In this chapter we review how the CAGE data can be integrated with other measurements such as expression, physical interactions and computational prediction of regulatory motifs, which together can provide a genome-wide picture of eukaryotic transcriptional regulatory networks at a new level of resolution. © 2010 by Pan Stanford Publishing Pte. Ltd. All rights reserved.

  2. Cathodic Cage Plasma Nitriding: An Innovative Technique

    Directory of Open Access Journals (Sweden)

    R. R. M. de Sousa

    2012-01-01

    Full Text Available Cylindrical samples of AISI 1020, AISI 316, and AISI 420 steels, with different heights, were simultaneously treated by a new technique of ionic nitriding, entitled cathodic cage plasma nitriding (CCPN, in order to evaluate the efficiency of this technique to produce nitrided layers with better properties compared with those obtained using conventional ionic nitriding technique. This method is able to eliminate the edge effect in the samples, promoting a better uniformity of temperature, and consequently, a smaller variation of the thickness/height relation can be obtained. The compound layers were characterized by X-ray diffraction, optical microscopy, and microhardness test profile. The results were compared with the properties of samples obtained with the conventional nitriding, for the three steel types. It was verified that samples treated by CCPN process presented, at the same temperature, a better uniformity in the thickness and absence of the edge effect.

  3. Evaluation of unilateral cage-instrumented fixation for lumbar spine

    Directory of Open Access Journals (Sweden)

    Chen Hung-Yi

    2010-11-01

    Full Text Available Abstract Background To investigate how unilateral cage-instrumented posterior lumbar interbody fusion (PLIF affects the three-dimensional flexibility in degenerative disc disease by comparing the biomechanical characteristics of unilateral and bilateral cage-instrumented PLIF. Methods Twelve motion segments in sheep lumbar spine specimens were tested for flexion, extension, axial rotation, and lateral bending by nondestructive flexibility test method using a nonconstrained testing apparatus. The specimens were divided into two equal groups. Group 1 received unilateral procedures while group 2 received bilateral procedures. Laminectomy, facectomy, discectomy, cage insertion and transpedicle screw insertion were performed sequentially after testing the intact status. Changes in range of motion (ROM and neutral zone (NZ were compared between unilateral and bilateral cage-instrumented PLIF. Results Both ROM and NZ, unilateral cage-instrumented PLIF and bilateral cage-instrumented PLIF, transpedicle screw insertion procedure did not revealed a significant difference between flexion-extension, lateral bending and axial rotation direction except the ROM in the axial rotation. The bilateral group's ROM (-1.7 ± 0. 8 of axial rotation was decreased significantly after transpedicle screw insertion procedure in comparison with the unilateral group (-0.2 ± 0.1. In the unilateral cage-instrumented PLIF group, the transpedicle screw insertion procedure did not demonstrate a significant difference between right and left side in the lateral bending and axial rotation direction. Conclusions Based on the results of this study, unilateral cage-instrumented PLIF and bilateral cage-instrumented PLIF have similar stability after transpedicle screw fixation in the sheep spine model. The unilateral approach can substantially reduce exposure requirements. It also offers the biomechanics advantage of construction using anterior column support combined with pedicle

  4. In-situ bioassays using caged bivalves

    Energy Technology Data Exchange (ETDEWEB)

    Salazar, M.H.; Salazar, S.M.

    1995-12-31

    It is important to make the distinction between chemical measurements to assess bioaccumulation potential versus biological measurements to assess potential bioeffects because bioaccumulation is not a bioeffect. Caging provides a unique opportunity to make synoptic measurements of each and facilitates making these measurements over space and time. Measuring bioaccumulation in resident and transplanted bivalves has probably been the most frequently used form of an in-situ bioassay because bivalves concentrate chemicals in their tissues. They are also easy to collect, cage, and measure. The authors have refined bivalve bioassay methods by minimizing the size range of test animals, making repetitive measurements of the same individuals, and standardizing test protocols for a variety of applications. They are now attempting to standardize criteria for accepting and interpreting data in the same way that laboratory bioassays have been standardized. Growth measurements can serve two purposes in this assessment strategy: (1) An integrated biological response endpoint that is easily quantifiable and with significance to the population, and (2) A means of calibrating bioaccumulation by assessing the relative health and physiological state of tissues that have accumulated the chemicals. In general, the authors have found the highest bioconcentration factors associated with the highest growth rates, the highest concentrations ({micro}g/g) of chemicals in juvenile mussels, and the highest chemical content ({micro}g/animal) in adult mussels. Without accounting for possible dilution of chemical concentrations by tissue growth or magnification through degrowth, contaminant concentrations can be misleading. Examples are provided for the Sudbury River in Massachusetts (Elliptio complanata), San Diego Bay (Mytilus galloprovincialis), and the Harbor Island Superfund Site in Puget Sound (Mytilus trossulus).

  5. A novel vented microisolation container for caging animals: microenvironmental comfort in a closed-system filter cage.

    Science.gov (United States)

    Rivard, G F; Neff, D E; Cullen, J F; Welch, S W

    2000-01-01

    We designed a closed-system cage with vent ports that would allow continuous airflow in the occupied cage to ensure adequate ventilation and gas exchange. In this system, the metabolic heat loads of mice generate upward thermal air currents. Heat exits via the exhaust port, and room air enters via the intake port, providing adequate ventilation. Simulations based on computational fluid dynamics (CFD) helped us to optimize the cage's design. CFD simulations and smoke visualizations with a feeder-trough assembly illustrated the one-pass air circulation pattern and the lack of air recirculation, turbulence, and dead air space in our system. We used hot-film anemometry and smoke-test methodologies to show that adequate ventilation was provided. In a room with still air (0 air changes per hour [ACH]), a cage fitted with double wire-cloth filters (40 mesh size) and occupied by five mice has at least 12 ACH, whereas the same cage occupied by one mouse has 6 ACH. After five mice had occupied the cage for a week, its average temperature was 0.58C, relative humidity was 34%, and ammonia concentration was 3 ppm higher than that of the room. Our novel vented microisolation cage provides adequate intracage ACH, isolates mice from environmental contaminants, and contains allergenic particles within the cage in an environment appropriate for the species.

  6. Dental prosthesis and buccal lesions in the elderly

    Directory of Open Access Journals (Sweden)

    Beatriz García Alpizar

    2010-02-01

    Full Text Available Fundament: Buccal lesions in the elderly are very frequent and they constitute a problem of health due to the consequences that cause. Objective: to describe the characteristics of the removable prosthesis used by the population of 60 and more years age and their relationship with the lesions of the oral mucosa. Methods: We carried out a study descriptive of cross section in 125 elderly with oral prosthesis. The characteristics of the removable prosthesis were described and their relationship with the lesions of the oral mucosa. The square chi tests and the analysis of relative risk were use to determine the association between the variables, also we used a logistical regression model to determine the independent relationship of each factor with the presence of the lesions. Results: We was a 12% of the people with stomatitis sub prosthesis, 8% presented lesions growth hyperplasic and 5,6% they were have angular queilitis. The lesions in the oral mucosa increased in people with prosthesis in not well state, bad hygiene this and in the female sex. Conclusion: the chronic lesions were the more prevalence in this study and they were very related with factors like: state of the conservation the prosthesis, time use, hygiene this and sex of the individual; but when determining the independent influence from each factor with the presence lesions, we established that only the state of conservation of the prosthesis and their hygiene affected of the important way to the old men of this study.

  7. Active upper limb prosthesis based on natural movement trajectories.

    Science.gov (United States)

    Ramírez-García, Alfredo; Leija, Lorenzo; Muñoz, Roberto

    2010-03-01

    The motion of the current prostheses is sequential and does not allow natural movements. In this work, complex natural motion patterns from a healthy upper limb were characterized in order to be emulated for a trans-humeral prosthesis with three degrees of freedom at the elbow. Firstly, it was necessary to define the prosthesis workspace, which means to establish a relationship using an artificial neural network (ANN), between the arm-forearm (3-D) angles allowed by the prosthesis, and its actuators length. The 3-D angles were measured between the forearm and each axis of the reference system attached at the elbow. Secondly, five activities of daily living (ADLs) were analyzed by means of the elbow flexion (EF), the forearm prono-supination (FPS) and the 3-D angles, from healthy subjects, by using a video-based motion analysis system. The 3-D angles were fed to the prosthesis model (ANN) in order to analyze which ADLs could be emulated by the prosthesis. As a result, a prosthesis kinematics approximation was obtained. In conclusion, in spite of the innovative mechanical configuration of the actuators, it was possible to carry out only three of the five ADLs considered. Future work will include improvement of the mechanical configuration of the prosthesis to have greater range of motion.

  8. Microbial colonization of Provox voice prosthesis in the Indian scenario

    Directory of Open Access Journals (Sweden)

    P Chaturvedi

    2014-01-01

    Full Text Available Introduction: Tracheoesophageal speech using the voice prosthesis is considered to be the "gold standard" with success rates as high as 90%. Despite significant developments, majority eventually develop dysfunction due to microbial deterioration. We did a pilot study of 58 laryngectomy patients who developed prosthesis dysfunction. Materials and Methods: A total of 58 laryngectomy patients who had their dysfunctional prosthesis removed were included in this study. Dysfunctional prostheses were removed and examined. Esophageal and tracheal flanges were examined separately. After obtaining pure fungal and bacterial cultures, the yeast strains were identified. Bacteria were identified with the light microscope and gram staining. We analyzed prosthesis lifespan and probable factors affecting it. Results: Central leak was found in 43% cases while in 57% peri-prosthetic leakage was the most common reason for prosthesis replacement. Microbial analysis revealed a combination of yeast and bacteria in approximately 55% culture samples. Out of these, almost 90% had the presence of single yeast species with bacteria. Pure fungal culture was identified in rest of the 45% cultures while none detected pure bacterial forms. Candida tropicalis was the solitary yeast in 81% while Candida albicans was seen in 10% as the solitary yeast. Bacterial isolates revealed Klebsiella pneumonia in 19%, Escherichia coli in 8% while Staphylococcus aureus was grown in 1% cultures. The consumption of curd (P = 0.036, 95% confidence intervals [CI]: 2.292-64.285 to have a significant correlation of the mean prosthesis lifespan. Consumption of curd (P = 0.001, 95% CI: 0.564-2.008 and history of prior radiotherapy (P = 0.015, 95% CI: 0.104-0.909 had a significant bearing on the Provox prosthesis lifespan. Conclusions: Candida is the most common organism grown on voice prosthesis in Indian scenario. Consumption of curd and history of prior radiotherapy significantly affect Provox

  9. A modified technique for retention of orbital prosthesis

    Directory of Open Access Journals (Sweden)

    Sameera R Shaikh

    2011-01-01

    Full Text Available An orbital defect (congenital or acquired causes severe facial asymmetry and disfigurement, which results in psychological and social disturbances to the patient. It becomes a challenging task for a maxillofacial prosthodontist to fabricate a prosthesis that replicates the healthy side of the face. Success of the prosthesis depends primarily on satisfactory retention of the same. This clinical report illustrates rehabilitation of a patient with an orbital defect by fabricating a hollow orbital prosthesis, utilizing anatomical undercuts for retention using an acrylic resin template relined by a resilient denture liner.

  10. The planimetric unfold method of fullerene cage structure

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Two kinds of planimetric diagrams, which consist of the boat form F6 and F5, the storm petrel form F6 and F5, respectively, were proposed to express the geometric structure of fullerene cage in this study. There are two chief advantages using the diagrams: (ⅰ) the spatial symmetrical characteristic of fullerene cage is not destroyed; (ⅱ) the coordination forms of F5 and F6 in the structure can be clearly expressed. This work has laid the foundation for studying the structural geometry of fullerene cage and its quantum chemistry and property.

  11. Electronic stimulators for surface neural prosthesis

    Directory of Open Access Journals (Sweden)

    Broderick Barry J.

    2008-01-01

    Full Text Available This paper presents the technological advancements in neural prosthesis devices using Functional Electrical Stimulation (FES. FES refers to the restoration of motor functions lost due to spinal cord injury (SCI, stroke, head injury, or diseases such as Cerebral Palsy or Multiple Sclerosis by eliciting muscular contractions through the use of a neuromuscular electrical stimulator device. The field has developed considerably since its inception, with the miniaturisation of circuity, the development of programmable and adaptable stimulators and the enhancement of sensors used to trigger the application of stimulation to suit a variety of FES applications. This paper discusses general FES system design requirements in the context of existing commercial and research FES devices, focusing on surface stimulators for the upper and lower limbs. These devices have demonstrated feasible standing and stepping in a clinical setting with paraplegic patients, improvements in dropped foot syndrome with hemiplegic patients and aided in the restoration of grasping function in patients with upper limb motor dysfunction.

  12. Galvanic gold plating for fixed dental prosthesis.

    Science.gov (United States)

    Ozcelik, Tuncer Burak; Yilmaz, Burak

    2013-07-01

    Metal ceramic partial fixed dental prostheses have been commonly used for the replacement of missing teeth for many years. Because of an increase in the price of gold, base metal alloys have been the choice of alloy for the fabrication of metal ceramic restorations in many dental clinics. Some major disadvantages of base metals are their corrosion and the dark coloration they may cause at the crown margins. This article describes a galvanic gold-plating technique, which is used to minimize corrosion and improve the esthetics of metal ceramic restorations fabricated with Cr-Co base metal alloys. This technique involves the deposition of a 6 μm to 8 μm 24 K gold layer directly onto the Cr-Co cast prosthesis framework. The technique improves metal surface properties, making them more biocompatible and usable, however, requires additional equipment and experienced laboratory technicians. Clinical studies should be performed to corroborate the long term success of this technique.

  13. New generation of actuators tailored to new ball valve; Neue Antriebsgeneration abgestimmt auf neuen Kugelhahn

    Energy Technology Data Exchange (ETDEWEB)

    Rudin, M. [Marktentwicklung Automatik, Georg Fischer Rohrleitungssysteme AG, Schaffhausen (Switzerland)

    2003-05-01

    Georg Fischer produces high-quality actuator systems of both pneumatic and electrical type for plastic piping systems. Customer benefits have been proven worldwide by the large numbers sold for use in the most diverse applications. These products have been re-engineered applying the latest technical potentials and taking account of future market needs. Georg Fisher will launch this new generation of actuator systems at the ACHEMA 2003. (orig.) [German] Georg Fischer produziert hochwertige Antriebe fuer Kunststoff-Rohrleitungssysteme sowohl in pneumatischer als auch in elektrischer Ausfuehrung. In grossen Stueckzahlen haben sie sich in verschiedensten Einsaetzen und Applikationen zum Nutzen der Kunden weltweit bewaehrt. Unter Anwendung neuester technischer Moeglichkeiten sowie unter Beruecksichtigung zukuenftiger Marktbeduerfnisse wurden diese Produkte einer Neuentwicklung unterzogen. Zur ACHEMA 2003 fuehrt Georg Fischer diese neue Antriebsgeneration in den Markt ein. (orig.)

  14. A laboratory silicone for preclinical training in ear prosthesis

    Science.gov (United States)

    Anand, Vijay; Haribabu; Vimala; Gnanasamband, Vimala

    2013-01-01

    This article describes an industrial elastic silicone as a material for the laboratory fabrication of ear prosthesis. It has been tested for toxicity in lab animals by the SGS India Pvt. Ltd and approved as a material to pass the parameter of abnormal toxicity. This material therefore can be safely recommended for laboratory exercise to fabricate facial prosthesis. The high cost of the maxillo facial silicone materials prohibits their use for facial prosthesis in pre-clinical training of post-graduate students in maxillofacial prosthodontics. For this reason, pre-clinical laboratory exercise in facial prosthesis is inadequate. A few institutions use polymethyl methacrylate resins which are rigid and do not have elastic characteristics of silicone, which is used for facial defects. This cost-effective industrial silicone material which mimics the elastic and color characteristics of the conventional silicones can be recommended for preclinical exercises. PMID:23956609

  15. Failed total carpometacarpal joint prosthesis of the thumb

    DEFF Research Database (Denmark)

    Hansen, Torben Bæk; Homilius, Morten

    2010-01-01

    . The male:female ratio was 1:4 and the mean duration of observation 32 months (range 6-52). In three patients the revised implant was a MOJE uncemented carpometacarpal joint prosthesis and in seven patients an Elektra uncemented one. At follow-up grip strength was reduced to less than 90% of the other hand...... in eight of 10 patients, but the mean Disabilities of the arm, shoulder, and hand (DASH) scores, self-reported pinch-grip-related function, and pain were comparable with our earlier published results with the Elektra carpometacarpal total joint prosthesis.......Total joint prosthesis in carpometacarpal joint arthritis of the thumb often fails. Loosening of the implant is often treated by resection arthroplasty, and we reviewed 10 patients, mean age 54 years (range 47-63) who were treated by resection arthroplasty after a failed total joint prosthesis...

  16. Characterization of an eye prosthesis using monopoly syrup

    Directory of Open Access Journals (Sweden)

    Pinki Bankoti

    2016-01-01

    Full Text Available The eye is a vital organ and an important component of facial expression. Loss of an eye has a crippling effect on the psychology of the patient. Maxillofacial prostheses restore and replace stomatognathic and associated facial structures with artificial substitutes. The objectives of eye prosthesis is to improve the patient esthetics, restore and maintain the health of the remaining associated structures, consequently provide physical and mental well-being. The primary purpose of an ocular prosthesis is to maintain the volume of eye socket and create the illusion of a healthy eye and surrounding tissue. A custom ocular prosthesis is a good option when reconstruction is done by plastic surgery, and osseointegrated implants are either not possible or not desired. A case of a custom-made ocular acrylic prosthesis is presented with acceptable fit, good retention, and esthetics.

  17. Retinal Prosthesis: A Potential Benefit for the Blind

    Institute of Scientific and Technical Information of China (English)

    YANG Xiao-jie

    2009-01-01

    Retinal degenerative diseases may induce the degeneration of outer retina and in turn, blindness. Nevertheless, due to the maintenance of inner retina, the coding and processing of visual neurons responses are still able to be executed naturally. Therefore,an effective retinal prosthesis device may be developed by mimicking the function of outer retina: transferring the visual light into artificial stimulus and delivering the stimulus to the retina aiming to evoke the neural responses. As two main developing directions for current retinal prosthesis,epiretinal (ER) and subretinal (SR) prosthesis are both undergoing experimental stage and possessing advantages and limitations. Further investigations in power supply, biocompatibility, etc.are still required. Additionally, suprachoroidal transretinal stimulation (STS) and neurotransmitter-induced stimulation as some other alternatives in retinal prosthesis are also considered as promising research directions, although they are not mature enough to be applied commercially, either.

  18. Association between dental prosthesis need, nutritional status and quality of life of elderly subjects

    DEFF Research Database (Denmark)

    Pillai, Rajath; Mathur, Vijay Prakash; Jain, Veena;

    2015-01-01

    To determine the effect of prosthesis need on nutritional status and oral health-related quality of life (OHrQoL) in elderly and to check the disparity between prosthesis need and prosthesis want in the Indian elderly. METHODS: A total of 946 geriatric participants reporting to a geriatric medicine...... need (r = -0.460). Participants with some prosthesis need had significantly lower MNA and GOHAI scores as compared to those with no prosthesis need. Though prosthesis need was high (79.7 %), demand was low (39.3 %). CONCLUSION: Prosthesis need affects nutritional status and OHrQoL in elderly...... clinic were recruited in the study. Mini-nutritional assessment (MNA), geriatric oral health assessment (GOHAI) indices, prosthesis need according to WHO criteria, and prosthesis want was recorded along with age, gender, socioeconomic status and posterior occluding pair. RESULTS: Significant associations...

  19. Biocompatible membrane of PDMS for the new chamber prosthesis stapes.

    Science.gov (United States)

    Banasik, Katarzyna; Kwacz, Monika

    2016-06-30

    Stapes protheses are designed for patients with otosclerosis resulting immobilization or significant reduction of the stapes mobility. All currently used prostheses are called - piston prosthesis. However, its use to stimulate the cochlea is still imperfect. New chamber stapes prosthesis allows the perilymph excitation more effective than the piston prothesis. Moreover, the chamber prosthesis eliminates the common causes of piston-stapedotomy failures. The most important element of the new prosthesis is a flexible membrane. The membrane stiffness should be close to the stiffness of normal annular ligament. This work presents the process of selection of the membrane's thickness and its manufacturing technology. Method A 3D model of the chamber stapes prosthesis was build using Autodesk Inventor 2015. The model was imported to Abacus 6.13 computing environment. During numerical simulations, displacements corresponding to applied loads were calculated and the membrane thickness was adjusted so that its stiffness was the same as the ligament stiffness (~ 120 N/m). The compliance ratios calculated from the load-displacement curves for the membrane and the annular ligament were verified using linear regression analysis. After determining the thickness, the manufacturing technology of the membrane was developed. Results The best similarity between the membrane's and annular ligament's stiffness was achieved for PDMS membrane with the 0,15- mm thickness (similarity ratio R2=0,997752). In this work, the technological parameters of spin-coating process for membrane manufacture are also presented. Summary The proper functioning of the chamber stapes prosthesis requires the PDMS membrane with a thickness of 0,15 mm. The 0,15-mm membrane has the tiffness close to the stiffness of the normal annular ligament. Therefore, the chamber stapes prosthesis provides the perilymph stimulation at the level comparable to the healthy ear. New prosthesis is currently under pre

  20. Kinematic Analysis of a Posterior-stabilized Knee Prosthesis

    Directory of Open Access Journals (Sweden)

    Zhi-Xin Zhao

    2015-01-01

    Full Text Available Background: The goal of total knee arthroplasty (TKA is to restore knee kinematics. Knee prosthesis design plays a very important role in successful restoration. Here, kinematics models of normal and prosthetic knees were created and validated using previously published data. Methods: Computed tomography and magnetic resonance imaging scans of a healthy, anticorrosive female cadaver were used to establish a model of the entire lower limbs, including the femur, tibia, patella, fibula, distal femur cartilage, and medial and lateral menisci, as well as the anterior cruciate, posterior cruciate, medial collateral, and lateral collateral ligaments. The data from the three-dimensional models of the normal knee joint and a posterior-stabilized (PS knee prosthesis were imported into finite element analysis software to create the final kinematic model of the TKA prosthesis, which was then validated by comparison with a previous study. The displacement of the medial/lateral femur and the internal rotation angle of the tibia were analyzed during 0-135° flexion. Results: Both the output data trends and the measured values derived from the normal knee′s kinematics model were very close to the results reported in a previous in vivo study, suggesting that this model can be used for further analyses. The PS knee prosthesis underwent an abnormal forward displacement compared with the normal knee and has insufficient, or insufficiently aggressive, "rollback" compared with the lateral femur of the normal knee. In addition, a certain degree of reverse rotation occurs during flexion of the PS knee prosthesis. Conclusions: There were still several differences between the kinematics of the PS knee prosthesis and a normal knee, suggesting room for improving the design of the PS knee prosthesis. The abnormal kinematics during early flexion shows that the design of the articular surface played a vital role in improving the kinematics of the PS knee prosthesis.

  1. Intraoral-extraoral combination prosthesis: improving retention using interconnecting magnets.

    Science.gov (United States)

    Engelen, Marloes; van Heumen, Celeste C M; Merkx, Matthias A W; Meijer, Gert J

    2014-01-01

    Osseointegrated implants have been well documented for retaining an obturator prosthesis as well as a facial prosthesis. However, when the defect extends to both the facial area and the maxilla, it is difficult to rehabilitate those defects to the satisfaction of the patient, especially in cases where implants cannot be placed on both sites. This case report describes the use of magnets to connect two prostheses, thereby increasing retention and patient comfort.

  2. Penile prosthesis surgery in the management of erectile dysfunction

    OpenAIRE

    2013-01-01

    Introduction We reviewed retrospectively the use of penile prostheses, including the indications and complications of penile prosthesis surgery. Methods We identified publications and the reported advances in penile prosthesis surgery between 1987 and 2012 in Pub-Med, and published information from American Medical Systems, Inc. (Minnetonka, MN, USA) and Coloplast Corporation (Humlebaek, Denmark), using the keywords ‘penile prosthesis’, ‘erectile dysfunction’, ‘mechanical reliability’, ‘compl...

  3. Kinematic Analysis of a Posterior-stabilized Knee Prosthesis

    Institute of Scientific and Technical Information of China (English)

    Zhi-Xin Zhao; Liang Wen; Tie-Bing Qu; Li-Li Hou; Dong Xiang; Jia Bin

    2015-01-01

    Background:The goal of total knee arthroplasty (TKA) is to restore knee kinematics.Knee prosthesis design plays a very important role in successful restoration.Here,kinematics models of normal and prosthetic knees were created and validated using previously published data.Methods:Computed tomography and magnetic resonance imaging scans of a healthy,anticorrosive female cadaver were used to establish a model of the entire lower limbs,including the femur,tibia,patella,fibula,distal femur cartilage,and medial and lateral menisci,as well as the anterior cruciate,posterior cruciate,medial collateral,and lateral collateral ligaments.The data from the three-dimensional models of the normal knee joint and a posterior-stabilized (PS) knee prosthesis were imported into finite element analysis software to create the final kinematic model of the TKA prosthesis,which was then validated by comparison with a previous study.The displacement of the medial/lateral femur and the internal rotation angle of the tibia were analyzed during 0-135° flexion.Results:Both the output data trends and the measured values derived from the normal knee's kinematics model were very close to the results reported in a previous in vivo study,suggesting that this model can be used for further analyses.The PS knee prosthesis underwent an abnormal forward displacement compared with the normal knee and has insufficient,or insufficiently aggressive,"rollback" compared with the lateral femur of the normal knee.In addition,a certain degree of reverse rotation occurs during flexion of the PS knee prosthesis.Conclusions:There were still several differences between the kinematics of the PS knee prosthesis and a normal knee,suggesting room for improving the design of the PS knee prosthesis.The abnormal kinematics during early flexion shows that the design of the articular surface played a vital role in improving the kinematics of the PS knee prosthesis.

  4. Cosmetic effect of knee joint in a knee disarticulation prosthesis

    OpenAIRE

    2015-01-01

    Despite numerous advantages, knee disarticulations (KDs) are rarely performed because of the anticipated KD prosthesis fitting problems that include the positioning of the knee joint distally from the KD socket. This results in lengthening of the thigh and subsequent shortening of the shank. The objective of this study was to assess the cosmetic effect of the knee joint in a KD prosthesis by determining the extent of the lengthening of the thigh and the shortening of the shank. This lengtheni...

  5. Design and Control of a Pneumatically Actuated Transtibial Prosthesis

    OpenAIRE

    Zheng, Hao; Shen, Xiangrong

    2015-01-01

    This paper presents the design and control of a pneumatically actuated transtibial prosthesis, which utilizes a pneumatic cylinder-type actuator to power the prosthetic ankle joint to support the user's locomotion. The pneumatic actuator has multiple advantages over the traditional electric motor, such as light weight, low cost, and high power-to-weight ratio. The objective of this work is to develop a compact and lightweight transtibial prosthesis, leveraging the multiple advantages provided...

  6. A digital patient for computer-aided prosthesis design

    OpenAIRE

    Colombo, Giorgio; Facoetti, Giancarlo; Rizzi, Caterina

    2013-01-01

    This article concerns the design of lower limb prosthesis, both below and above knee. It describes a new computer-based design framework and a digital model of the patient around which the prosthesis is designed and tested in a completely virtual environment. The virtual model of the patient is the backbone of the whole system, and it is based on a biomechanical general-purpose model customized with the patient's characteristics (e.g. anthropometric measures). The software platform adopts com...

  7. Literature Review on Needs of Upper Limb Prosthesis Users

    OpenAIRE

    Cordella, Francesca; Ciancio, Anna Lisa; Sacchetti, Rinaldo; Davalli, Angelo; Cutti, Andrea Giovanni; Guglielmelli, Eugenio; Zollo, Loredana

    2016-01-01

    The loss of one hand can significantly affect the level of autonomy and the capability of performing daily living, working and social activities. The current prosthetic solutions contribute in a poor way to overcome these problems due to limitations in the interfaces adopted for controlling the prosthesis and to the lack of force or tactile feedback, thus limiting hand grasp capabilities. This paper presents a literature review on needs analysis of upper limb prosthesis users, and points out ...

  8. Linear diffusion into a Faraday cage.

    Energy Technology Data Exchange (ETDEWEB)

    Warne, Larry Kevin; Lin, Yau Tang; Merewether, Kimball O.; Chen, Kenneth C.

    2011-11-01

    Linear lightning diffusion into a Faraday cage is studied. An early-time integral valid for large ratios of enclosure size to enclosure thickness and small relative permeability ({mu}/{mu}{sub 0} {le} 10) is used for this study. Existing solutions for nearby lightning impulse responses of electrically thick-wall enclosures are refined and extended to calculate the nearby lightning magnetic field (H) and time-derivative magnetic field (HDOT) inside enclosures of varying thickness caused by a decaying exponential excitation. For a direct strike scenario, the early-time integral for a worst-case line source outside the enclosure caused by an impulse is simplified and numerically integrated to give the interior H and HDOT at the location closest to the source as well as a function of distance from the source. H and HDOT enclosure response functions for decaying exponentials are considered for an enclosure wall of any thickness. Simple formulas are derived to provide a description of enclosure interior H and HDOT as well. Direct strike voltage and current bounds for a single-turn optimally-coupled loop for all three waveforms are also given.

  9. Ischemic Gangrene of the Glans following Penile Prosthesis Implantation

    Science.gov (United States)

    García Gómez, Borja; Romero Otero, Javier; Díez Sicilia, Laura; Jiménez Alcaide, Estibaliz; García-Cruz, Eduardo; Rodríguez Antolín, Alfredo

    2013-01-01

    The development of ischemic gangrene of the penis following implantation of prosthesis is unusual, and very few cases are available in the literature. As a result, no established treatment protocol is available. We report our experience within a case of gangrene of the glans following implantation of a three-component prosthesis. We present a 53-year-old male, smoker with diabetes and hypercholesterolemia, who underwent surgery for the insertion of a penile prosthesis with 3 components to correct his erectile dysfunction and severe Peyronie's disease. The procedure was carried out without incidents. During the postoperative period, the patient began to complain from penile and perineal pain. He developed avascular necrosis of the glans. The necrosed area was excised. Four weeks later, he developed fever and perineal pain arriving to the emergency room with the prosthesis extruding through the glans. He had emergency surgery to remove the prosthesis plus surgical lavage and was prescribed broad-spectrum antibiotic therapy. Four weeks later, the penis was completely revascularized and reepithelialized. Ischemic gangrene following penile prosthesis implantation takes place in patients with poor peripheral vascularisation. Diabetes mellitus has been the common denominator to all of the reported cases. PMID:23956919

  10. Ischemic Gangrene of the Glans following Penile Prosthesis Implantation

    Directory of Open Access Journals (Sweden)

    Borja García Gómez

    2013-01-01

    Full Text Available The development of ischemic gangrene of the penis following implantation of prosthesis is unusual, and very few cases are available in the literature. As a result, no established treatment protocol is available. We report our experience within a case of gangrene of the glans following implantation of a three-component prosthesis. We present a 53-year-old male, smoker with diabetes and hypercholesterolemia, who underwent surgery for the insertion of a penile prosthesis with 3 components to correct his erectile dysfunction and severe Peyronie's disease. The procedure was carried out without incidents. During the postoperative period, the patient began to complain from penile and perineal pain. He developed avascular necrosis of the glans. The necrosed area was excised. Four weeks later, he developed fever and perineal pain arriving to the emergency room with the prosthesis extruding through the glans. He had emergency surgery to remove the prosthesis plus surgical lavage and was prescribed broad-spectrum antibiotic therapy. Four weeks later, the penis was completely revascularized and reepithelialized. Ischemic gangrene following penile prosthesis implantation takes place in patients with poor peripheral vascularisation. Diabetes mellitus has been the common denominator to all of the reported cases.

  11. Ideas on the suspension of the below-knee prosthesis.

    Science.gov (United States)

    Grevsten, S

    1978-04-01

    Comparative studies with the PTB-suction prosthesis and the ordinary PTB prosthesis have provided opportunities to analyze and understand some functional differences in the suspension of below-knee prostheses. In a roentgenological study of the stump-socket contact signficantly less vertical displacement in the PTB-suction prosthesis has been shown. A study of the pressure variations in the suction socket verified the theory of the necessary pressure gradient in the PTB-suction socket. Added negative pressure by muscle action was also observed. An electromyographic study suggested a muscular activity pattern in the suction prosthesis similar to that of a normal leg, as a contrast to the ordinary PTB prosthesis where simultaneous contractions of antagonistic muscles seemed to be the usual pattern. The latter is interpreted as a defence reaction. An optimal prosthesis has been deduced. It shall have a soft prosthetic socket with a perfect fit, a suction, adhesion and friction fixation and a pressure gradient between the skin and the socket wall with minimum compression distally. The plaster casting shall be done in a downward modelling manner making available space for soft tissue without compression.

  12. A new porous tracheal prosthesis sealed with collagen sponge.

    Science.gov (United States)

    Teramachi, M; Kiyotani, T; Takimoto, Y; Nakamura, T; Shimizu, Y

    1995-01-01

    We have designed a new tracheal prosthesis to overcome problems with an earlier device, which included stenosis and exposure of its constituent mesh. A polypropylene mesh cylinder, reinforced with a polypropylene spiral, is sealed with collagen sponge made from porcine dermal collagen. Using this prosthesis, we performed cervical tracheal reconstructions on 11 dogs. Three dogs died within 3 months of reconstruction. Their causes of death were anesthetic accident, diarrhea, and suffocation, respectively. Bronchoscopically, the inner surface of the prosthesis was almost covered with host tissue by 2 months. However, in one dog, a relatively large area of the mesh was exposed in the tracheal lumen at 6 months; a smaller area was exposed in two other dogs. The appearance of the inner surface rapidly became lustrous, and central stenosis was not significant, even after 12 months. Histologically, an incomplete epithelial lining at 6 months was seen on the reconstructed surface and included ciliated columnar, cuboidal, and squamous epithelium. These observations have revealed that this prosthesis has high biocompatibility and the potential to overcome problems of stenosis of the prosthesis lumen. However, because ulceration persists with this prosthesis, additional improvement is needed to reduce the incidence of mesh exposure.

  13. Multiexpandable cage for minimally invasive posterior lumbar interbody fusion

    Science.gov (United States)

    Coe, Jeffrey D; Zucherman, James F; Kucharzyk, Donald W; Poelstra, Kornelis A; Miller, Larry E; Kunwar, Sandeep

    2016-01-01

    The increasing adoption of minimally invasive techniques for spine surgery in recent years has led to significant advancements in instrumentation for lumbar interbody fusion. Percutaneous pedicle screw fixation is now a mature technology, but the role of expandable cages is still evolving. The capability to deliver a multiexpandable interbody cage with a large footprint through a narrow surgical cannula represents a significant advancement in spinal surgery technology. The purpose of this report is to describe a multiexpandable lumbar interbody fusion cage, including implant characteristics, intended use, surgical technique, preclinical testing, and early clinical experience. Results to date suggest that the multiexpandable cage allows a less invasive approach to posterior/transforaminal lumbar interbody fusion surgery by minimizing iatrogenic risks associated with static or vertically expanding interbody prostheses while providing immediate vertebral height restoration, restoration of anatomic alignment, and excellent early-term clinical results. PMID:27729817

  14. Fabrication of an Implant-Supported Fixed Interim Prosthesis Using a Duplicate Denture: An Alternative Technique.

    Science.gov (United States)

    Al-Thobity, Ahmad M

    2016-06-22

    The fabrication of an implant-supported fixed complete denture prosthesis involves multiple clinical and laboratory steps. One of the main steps is to provide the patient with an interim fixed prosthesis to evaluate the patient's esthetic and functional needs as well as to enhance the patient's psychology before proceeding to the definitive prosthesis. Different techniques for fabricating interim prostheses have been described in the literature. This report describes an alternative technique that uses a duplicate denture made of self-curing acrylic resin to fabricate an implant-supported fixed interim prosthesis. The interim prosthesis was later used as a blueprint for the definitive implant-supported hybrid prosthesis.

  15. Homogenized boundary conditions and resonance effects in Faraday cages

    Science.gov (United States)

    Hewett, D. P.; Hewitt, I. J.

    2016-05-01

    We present a mathematical study of two-dimensional electrostatic and electromagnetic shielding by a cage of conducting wires (the so-called `Faraday cage effect'). Taking the limit as the number of wires in the cage tends to infinity, we use the asymptotic method of multiple scales to derive continuum models for the shielding, involving homogenized boundary conditions on an effective cage boundary. We show how the resulting models depend on key cage parameters such as the size and shape of the wires, and, in the electromagnetic case, on the frequency and polarization of the incident field. In the electromagnetic case, there are resonance effects, whereby at frequencies close to the natural frequencies of the equivalent solid shell, the presence of the cage actually amplifies the incident field, rather than shielding it. By appropriately modifying the continuum model, we calculate the modified resonant frequencies, and their associated peak amplitudes. We discuss applications to radiation containment in microwave ovens and acoustic scattering by perforated shells.

  16. Homogenized boundary conditions and resonance effects in Faraday cages

    Science.gov (United States)

    Hewitt, I. J.

    2016-01-01

    We present a mathematical study of two-dimensional electrostatic and electromagnetic shielding by a cage of conducting wires (the so-called ‘Faraday cage effect’). Taking the limit as the number of wires in the cage tends to infinity, we use the asymptotic method of multiple scales to derive continuum models for the shielding, involving homogenized boundary conditions on an effective cage boundary. We show how the resulting models depend on key cage parameters such as the size and shape of the wires, and, in the electromagnetic case, on the frequency and polarization of the incident field. In the electromagnetic case, there are resonance effects, whereby at frequencies close to the natural frequencies of the equivalent solid shell, the presence of the cage actually amplifies the incident field, rather than shielding it. By appropriately modifying the continuum model, we calculate the modified resonant frequencies, and their associated peak amplitudes. We discuss applications to radiation containment in microwave ovens and acoustic scattering by perforated shells. PMID:27279775

  17. Caged Protein Prenyltransferase Substrates: Tools for Understanding Protein Prenylation

    Energy Technology Data Exchange (ETDEWEB)

    DeGraw, Amanda J.; Hast, Michael A.; Xu, Juhua; Mullen, Daniel; Beese, Lorena S.; Barany, George; Distefano, Mark D. (Duke); (UMM)

    2010-11-15

    Originally designed to block the prenylation of oncogenic Ras, inhibitors of protein farnesyltransferase currently in preclinical and clinical trials are showing efficacy in cancers with normal Ras. Blocking protein prenylation has also shown promise in the treatment of malaria, Chagas disease and progeria syndrome. A better understanding of the mechanism, targets and in vivo consequences of protein prenylation are needed to elucidate the mode of action of current PFTase (Protein Farnesyltransferase) inhibitors and to create more potent and selective compounds. Caged enzyme substrates are useful tools for understanding enzyme mechanism and biological function. Reported here is the synthesis and characterization of caged substrates of PFTase. The caged isoprenoid diphosphates are poor substrates prior to photolysis. The caged CAAX peptide is a true catalytically caged substrate of PFTase in that it is to not a substrate, yet is able to bind to the enzyme as established by inhibition studies and X-ray crystallography. Irradiation of the caged molecules with 350 nm light readily releases their cognate substrate and their photolysis products are benign. These properties highlight the utility of those analogs towards a variety of in vitro and in vivo applications.

  18. Homogenized boundary conditions and resonance effects in Faraday cages.

    Science.gov (United States)

    Hewett, D P; Hewitt, I J

    2016-05-01

    We present a mathematical study of two-dimensional electrostatic and electromagnetic shielding by a cage of conducting wires (the so-called 'Faraday cage effect'). Taking the limit as the number of wires in the cage tends to infinity, we use the asymptotic method of multiple scales to derive continuum models for the shielding, involving homogenized boundary conditions on an effective cage boundary. We show how the resulting models depend on key cage parameters such as the size and shape of the wires, and, in the electromagnetic case, on the frequency and polarization of the incident field. In the electromagnetic case, there are resonance effects, whereby at frequencies close to the natural frequencies of the equivalent solid shell, the presence of the cage actually amplifies the incident field, rather than shielding it. By appropriately modifying the continuum model, we calculate the modified resonant frequencies, and their associated peak amplitudes. We discuss applications to radiation containment in microwave ovens and acoustic scattering by perforated shells.

  19. Multicomponent Protein Cage Architectures for Photocatalysis

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, Arunava [Univ. of Alabama, Tuscaloosa, AL (United States); Prevelige, Peter E [Univ. of Alabama, Birmingham, AL (United States)

    2016-01-04

    The primary goal of the project was to develop protein-templated approaches for the synthesis and directed assembly of semiconductor nanomaterials that are efficient for visible light absorption and hydrogen production. In general, visible-light-driven photocatalysis reactions exhibit low quantum efficiency for solar energy conversion primarily because of materials-related issues and limitations, such as the control of the band gap, band structure, photochemical stability, and available reactive surface area of the photocatalyst. Synthesis of multicomponent hierarchical nano-architectures, consisting of semiconductor nanoparticles (NPs) with desired optical properties fabricated to maximize spatial proximity for optimum electron and energy transfer represents an attractive route for addressing the problem. Virus capsids are highly symmetrical, self-assembling protein cage nanoparticles that exist in a range of sizes and symmetries. Selective deposition of inorganic, by design, at specific locations on virus capsids affords precise control over the size, spacing, and assembly of nanomaterials, resulting in uniform and reproducible nano-architectures. We utilized the self-assembling capabilities of the 420 subunit, 60 nm icosahedral, P22 virus capsid to direct the nucleation, growth, and proximity of a range of component materials. Controlled fabrication on the exterior of the temperature stable shell was achieved by genetically encoding specific binding peptides into an externally exposed loop which is displayed on each of the 420 coat protein subunits. Localization of complimentary materials to the interior of the particle was achieved through the use “scaffolding-fusion proteins. The scaffolding domain drives coat protein polymerization resulting in a coat protein shell surrounding a core of approximately 300 scaffolding/fusion molecules. The fusion domain comprises a peptide which specifically binds the semiconductor material of interest.

  20. Automated home cage observations as a tool to measure the effects of wheel running on cage floor locomotion.

    Science.gov (United States)

    de Visser, Leonie; van den Bos, Ruud; Spruijt, Berry M

    2005-05-28

    This paper introduces automated observations in a modular home cage system as a tool to measure the effects of wheel running on the time distribution and daily organization of cage floor locomotor activity in female C57BL/6 mice. Mice (n = 16) were placed in the home cage system for 6 consecutive days. Fifty percent of the subjects had free access to a running wheel that was integrated in the home cage. Overall activity levels in terms of duration of movement were increased by wheel running, while time spent inside a sheltering box was decreased. Wheel running affected the hourly pattern of movement during the animals' active period of the day. Mice without a running wheel, in contrast to mice with a running wheel, showed a clear differentiation between novelty-induced and baseline levels of locomotion as reflected by a decrease after the first day of introduction to the home cage. The results are discussed in the light of the use of running wheels as a tool to measure general activity and as an object for environmental enrichment. Furthermore, the possibilities of using automated home cage observations for e.g. behavioural phenotyping are discussed.

  1. CAGE BREEDING OF WARM WATER FRESHWATER FISH SPECIES

    Directory of Open Access Journals (Sweden)

    Roman Safner

    2008-10-01

    Full Text Available In the 1970s, Croatia became actively involved in the contemporary trend of breeding fish in floating cages. In addition to various species of marine fishes, breeding was attempted with trout, carp, catfish, cisco and salmon. Of the above freshwater fish species, specific standards were established only for the cage breeding of rainbow trout. Cage breeding of the remaining species remained at the level of occasional attempts, with more of an experimental than a commercial character. The regular attempts to master this technique for cage breeding of warm water freshwater fish species were aimed at achieving the known benefits of such breeding, such as simplicity of implementing technological measures, easier establishment of the breeding system, simpler manipulation, the possibility of denser colonies per unit volume with a high level of production, easier adaptations to market conditions and fewer initial structural investments. Despite the many advantages, the main reasons for the lack of greater implementation of the cage breeding technology for warm water species of freshwater fish include problems in obtaining the appropriate category and quantity of healthy fry, the specificity and applicability of physical and chemical properties of the recipients and human error. In evaluating the advantages and disadvantages, the final decision on the justification of cage breeding for individual warm water freshwater species must be based on both biological and economic factors. Based on the knowledge of cage breeding acquired to date, the rule for virtually all intensive breeding systems is that it is only recommended for those species with high market demand and a high market price. The technology that demands nutrition with highly concentrated feed and other production expenditures is costly, and is therefore not profitable with less expensive fish species. Furthermore, production must be market oriented, i.e. the appropriate market research measures

  2. Intraoral framework pick-up technique to improve fit of a metal-resin implant prosthesis

    Directory of Open Access Journals (Sweden)

    Mirza Rustum Baig

    2012-01-01

    Full Text Available The achievement of passive fit is an important prerequisite for the prevention of complications in full-arch screw-retained implant prosthesis. With cemented prosthesis, the cementation compensates for the discrepancies in the cast framework, but the lack of retrievability seems undesirable. The aim of this paper is to propose a modified screw-retained prosthesis design for complete arch implant fixed rehabilitation. A technique for the fabrication of a full-arch metal-resin implant-supported screw-retained prosthesis is described. Cementation of the framework to the abutments intraorally improves the passivity of fit of the prosthesis on the implants. Maintenance of screw-access channels in the final prosthesis ensures retrievability. The metal-resin design allows for easy repair and maintenance. The prosthesis is cost-effective compared to conventional options and can be employed as a viable treatment alternative when considering metal-acrylic resin complete arch fixed prosthesis.

  3. Cortical bone total ossicular replacement prosthesis

    Directory of Open Access Journals (Sweden)

    Manu Malhotra

    2014-01-01

    Full Text Available Objectives: Evaluate an autologous cortical bone total ossicular replacement prosthesis (B TORP made of cortical bone for cost effective and sustainable hearing results. Materials and Methods: A prospective study was undertaken in the patients who underwent tympanoplasty with new B-TORP from January 2011 to December 2011. All patients had an absent superstructure of the stapes and long process of the incus due to chronic otitis media. Totally 40 patients were evaluated. Hearing results were evaluated using four-frequency average pure tone air conduction and air-bone gap (ABG measured at 0.5, 1, 2, and 3 kHz after a period of 12 months. Pre- and post-operative continuous variables were compared using a paired t-test and data from unequal groups were assessed for significant differences using unpaired t-test. Results: Successful rehabilitation of the ABG to 20 dB or less was achieved in 95% of patients. Overall mean improvement in ABG was 25.8 ± 5.6 dB, which was statistically significant (t = 26.8, P 0.5. Conclusion: The new autologous B-TORP provides sustainable hearing improvement and is bio-compatible, stable, and magnetic resonance imaging compatible.

  4. [Avoidance of patient-prosthesis mismatch].

    Science.gov (United States)

    Sakamoto, Y; Hashimoto, K

    2006-04-01

    To minimize the incidence of patient-prosthesis mismatch (PPM), we have routinely adopted aortic root enlargement to avoid PPM for patients with small aortic annulus. The aim of this study was to review our strategy of avoiding PPM. The Carpentier-Edwards Perimount (CEP) valves were implanted in 53 patients who were mostly aged over 65 and the St. Jude Medical (SJM) mechanical valves were used in 128 patients aged under 65. A standard 21-mm SJM valve was used in only 3 patients and no 19-mm valves were employed. However, 19-mm CEP valves were used in 12 patients with a small body surface area (1.43 +/- 0.14 m2). Of these, 26 patients (14.4%) who had a small aortic annulus and 24 patients aged under 65 underwent aortic root enlargement. No patient receiving an SJM valve had an projected indexed effective orifice area (EOAI) small annulus, the first choice for avoiding PPM is aortic annular enlargement, which may be avoided by high performance mechanical valves with larger EOA.

  5. Boston ocular surface prosthesis: An Indian experience

    Directory of Open Access Journals (Sweden)

    Varsha Madanlal Rathi

    2011-01-01

    Full Text Available Context: Boston ocular surface prosthesis (BOSP is a scleral contact lens used in the management of patients who are rigid gas permeable (RGP failures as with corneal ectasias such as keratoconus and in those patients who have ocular surface disease such as Stevens-Johnson syndrome (SJS. Aim: To report utilization of BOSP in a tertiary eye care center in India. Materials and Methods: We retrospectively reviewed charts of 32 patients who received BOSP from July 2008 to May 2009. Indications for fitting these lenses, improvement in visual acuity (VA before and after lens fitting and relief of symptoms of pain and photophobia were noted. Paired t-test was used for statistical analysis using SPSS version 16.0 for Windows. Results: Thirty-two patients (43 eyes received these lenses. These consisted of 23 eyes of 17 patients who failed RGP trials for irregular astigmatism and corneal ectasia such as keratoconus and post radial keratotomy and scar and 20 eyes of 15 patients with SJS. Mean age of RGP failures was 27.94 years. Pre- and post-BOSP wear mean LogMAR VA was 1.13 and 0.29, respectively, in RGP failures. The P value was statistically significant (P 2 lines in 7/20 eyes (35% with SJS, with improvement in symptoms. Conclusion: BOSP improves VA in patients who have irregular astigmatism as in ectasias and RGP failures and improves vision and symptoms in patients with SJS.

  6. Metabolic Prosthesis for Oxygenation of Ischemic Tissue

    Energy Technology Data Exchange (ETDEWEB)

    Greenbaum, Elias [ORNL

    2009-01-01

    This communication discloses new ideas and preliminary results on the development of a "metabolic prosthesis" for local oxygenation of ischemic tissue under physiological neutral conditions. We report for the first time the selective electrolysis of physiological saline by repetitively pulsed charge-limited electrolysis for the production of oxygen and suppression of free chlorine. For example, using 800 A amplitude current pulses and <200 sec pulse durations, we demonstrated prompt oxygen production and delayed chlorine production at the surface of a shiny 0.85 mm diameter spherical platinum electrode. The data, interpreted in terms of the ionic structure of the electric double layer, suggest a strategy for in situ production of metabolic oxygen via a new class of "smart" prosthetic implants for dealing with ischemic disease such as diabetic retinopathy. We also present data indicating that drift of the local pH of the oxygenated environment can be held constant using a feedback-controlled three electrode electrolysis system that chooses anode and cathode pair based on pH data provided by local microsensors. The work is discussed in the context of diabetic retinopathy since surgical techniques for multielectrode prosthetic implants aimed at retinal degenerative diseases have been developed.

  7. Finite element modeling of retinal prosthesis mechanics

    Science.gov (United States)

    Basinger, B. C.; Rowley, A. P.; Chen, K.; Humayun, M. S.; Weiland, J. D.

    2009-10-01

    Epiretinal prostheses used to treat degenerative retina diseases apply stimulus via an electrode array fixed to the ganglion cell side of the retina. Mechanical pressure applied by these arrays to the retina, both during initial insertion and throughout chronic use, could cause sufficient retinal damage to reduce the device's effectiveness. In order to understand and minimize potential mechanical damage, we have used finite element analysis to model mechanical interactions between an electrode array and the retina in both acute and chronic loading configurations. Modeling indicates that an acute tacking force distributes stress primarily underneath the tack site and heel edge of the array, while more moderate chronic stresses are distributed more evenly underneath the array. Retinal damage in a canine model chronically implanted with a similar array occurred in correlating locations, and model predictions correlate well with benchtop eyewall compression tests. This model provides retinal prosthesis researchers with a tool to optimize the mechanical electrode array design, but the techniques used here represent a unique effort to combine a modifiable device and soft biological tissues in the same model and those techniques could be extended to other devices that come into mechanical contact with soft neural tissues.

  8. Long term preservation of motion with artificial cervical disc implants: A comparison between cervical disc replacement and rigid fusion with cage

    Science.gov (United States)

    Cincu, Rafael; Lorente, Francisco de Asis; Gomez, Joaquin; Eiras, Jose; Agrawal, Amit

    2014-01-01

    Background: With the advancement of technologies there is more interest in the maintenance of the spine's biomechanical properties focusing on the preservation of the functional motion segment. In present article we describe our experience with 25 cases managed with artificial cervical discs with 28 Solis cage following cervical discectomy with a mean follow-up period of 7.5 year. Materials and Methods: All surgeries were performed by single surgeon from March 2004 to June 2005 with a follow-up till date. Patients with symptomatic single or multiple level diseases that had no prior cervical surgery were candidates for the study. Cohort demographics were comparable. Standardized clinical outcome measures and radiographic examinations were used at prescribed post-operative intervals to compare the treatment groups. Relief in radicular pain, cervical spine motion, and degenerative changes at follow-up were noted. Results: In a total 53 cases, the mean age in prosthesis group was 47 years (age range: 30-63 years) and mean age in cage group was 44 years (32-62 years). Mean hospital stay was 2.7 days in both the groups. At 4 weeks complete cervical movements could be achieved in 19 cases in artificial disc group. Maintenance of movement after 7.5 years was in 76% of these patients. Lordosis was maintained in all cases till date. There was no mortality or wound infection in our series. Conclusions: We conclude that artificial cervical disc could be an alternative to fixed spinal fusion as it represents the most physiological substitute of disc. However, there is need for further studies to support the use of artificial cervical disc prosthesis. PMID:25685218

  9. [The treatment of abdominal aortic aneurysms by use of endovascular prosthesis and classic vascular prosthesis].

    Science.gov (United States)

    Pupka, Artur; Szyber, Przemysław P; Janczak, Dariusz; Pawłowski, Stanisław; Szyber, Piotr

    2006-01-01

    The abdominal aortic aneurysm is a dilatation of infrarenal part of aorta. Its ethiology is still unknown. An infection and congenital disorders of conjunctive tissue are regarded as the main risc factors. Other factors could be a perimural thrombus and elastin and colagen degradation. It's not proved that atheromatosis is a risc factor. The disease concerns mainly the old males. Not treated aneurysm grows until rupture. The aneurysms are usually asympthomatic. Majority of them are found incidentally. Ultrasonography and computed tomography are used to extended diagnosis. The open surgery or endovascular surgery are only possible ways of treatment. The aneurysm with diameter over 55 milimeters, sympthomatic or rupted is an indication for surgery. The aim of the open surgery is implantation of the vascular prosthesis into retroperitoneal space. Endovascular method consist in placement of stent-graft in the lumen of aneurysm through small incision in a peripherial vessel. Stent-graft consists of metal chassis covered by classic vascular prosthesis. This method still requires the long-term assessment.

  10. Design and Testing of a Bionic Dancing Prosthesis.

    Directory of Open Access Journals (Sweden)

    Elliott J Rouse

    Full Text Available Traditionally, prosthetic leg research has focused on improving mobility for activities of daily living. Artistic expression such as dance, however, is not a common research topic and consequently prosthetic technology for dance has been severely limited for the disabled. This work focuses on investigating the ankle joint kinetics and kinematics during a Latin-American dance to provide unique motor options for disabled individuals beyond those of daily living. The objective of this study was to develop a control system for a bionic ankle prosthesis that outperforms conventional prostheses when dancing the rumba. The biomechanics of the ankle joint of a non-amputee, professional dancer were acquired for the development of the bionic control system. Subsequently, a professional dancer who received a traumatic transtibial amputation in April 2013 tested the bionic dance prosthesis and a conventional, passive prosthesis for comparison. The ability to provide similar torque-angle behavior of the biological ankle was assessed to quantify the biological realism of the prostheses. The bionic dancing prosthesis overlapped with 37 ± 6% of the non-amputee ankle torque and ankle angle data, compared to 26 ± 2% for the conventional, passive prosthesis, a statistically greater overlap (p = 0.01. This study lays the foundation for quantifying unique, expressive activity modes currently unavailable to individuals with disabilities. Future work will focus on an expansion of the methods and types of dance investigated in this work.

  11. Design and Testing of a Bionic Dancing Prosthesis

    Science.gov (United States)

    Rouse, Elliott J.; Villagaray-Carski, Nathan C.; Emerson, Robert W.; Herr, Hugh M.

    2015-01-01

    Traditionally, prosthetic leg research has focused on improving mobility for activities of daily living. Artistic expression such as dance, however, is not a common research topic and consequently prosthetic technology for dance has been severely limited for the disabled. This work focuses on investigating the ankle joint kinetics and kinematics during a Latin-American dance to provide unique motor options for disabled individuals beyond those of daily living. The objective of this study was to develop a control system for a bionic ankle prosthesis that outperforms conventional prostheses when dancing the rumba. The biomechanics of the ankle joint of a non-amputee, professional dancer were acquired for the development of the bionic control system. Subsequently, a professional dancer who received a traumatic transtibial amputation in April 2013 tested the bionic dance prosthesis and a conventional, passive prosthesis for comparison. The ability to provide similar torque-angle behavior of the biological ankle was assessed to quantify the biological realism of the prostheses. The bionic dancing prosthesis overlapped with 37 ± 6% of the non-amputee ankle torque and ankle angle data, compared to 26 ± 2% for the conventional, passive prosthesis, a statistically greater overlap (p = 0.01). This study lays the foundation for quantifying unique, expressive activity modes currently unavailable to individuals with disabilities. Future work will focus on an expansion of the methods and types of dance investigated in this work. PMID:26285201

  12. [Design and study of carbon fiber tracheal prosthesis].

    Science.gov (United States)

    Qi, L; Liu, D; Han, Z; Wang, F

    1998-12-01

    32 healty adult dogs were selected for this experiment. 10 of them were subjected to the tracheal biomechanics test using indices including the relation between stretcher ratio (lambda) and stress (T), the squeeze stress (delta jy) of medical silk thread on trachea, the side stress (Ts) inducing the tracheal collapse, the functional maximum angle (psi max) of tracheal, and the sever area torsion angle (theta max) of tracheal functional maximum curved. According to the indices measured, two types of tracheal prosthesis were designed, and were made of carbon fiber and silicon. They were the straight tube type tracheal prosthesis and the bifurcate type tracheal prosthesis. The straight tube type tracheal prosthesis was studied with a design of two groups comprising a total of 11 dogs. In the experiment group (n = 6), the outer surface of the tube was not coated with silicon, the average survival period was 379.8 days. In the control group (n = 5), the outer surface of the tube was coated with silicon, the average survival period was 90.4 days. The bifurcate type tracheal prosthesis was studied in 11 dogs, the average survival period was 4.32 days. The main causes of death in the experiment were infection and anastomotic dehiscent.

  13. Estimation of crank angle for cycling with a powered prosthesis.

    Science.gov (United States)

    Lawson, B E; Shultz, A; Ledoux, E; Goldfarb, M

    2014-01-01

    In order for a prosthesis to restore power generation during cycling, it must supply torque in a manner that is coordinated with the motion of the bicycle crank. This paper outlines an algorithm for the real time estimation of the angular position of a bicycle crankshaft using only measurements internal to an intelligent knee and ankle prosthesis. The algorithm assumes that the rider/prosthesis/bicycle system can be modeled as a four-bar mechanism. Assuming that a prosthesis can generate two independent angular measurements of the mechanism (in this case the knee angle and the absolute orientation of the shank), Freudenstein's equation can be used to synthesize the mechanism continuously. A recursive least-squares algorithm is implemented to estimate the Freudenstein coefficients, and the resulting link lengths are used to reformulate the equation in terms of input-output relationships mapping both measured angles to the crank angle. Using two independent measurements allows the algorithm to uniquely determine the crank angle from multi-valued functions. In order to validate the algorithm, a bicycle was mounted on a trainer and configured with the prosthesis using an artificial hip joint attached to the seat post. Motion capture was used to monitor the mechanism for forward and backward pedaling and the results are compared to the output of the presented algorithm. Once the parameters have converged, the algorithm is shown to predict the crank angle within 15° of the externally measured value throughout the entire crank cycle during forward rotation.

  14. Design and Testing of a Bionic Dancing Prosthesis.

    Science.gov (United States)

    Rouse, Elliott J; Villagaray-Carski, Nathan C; Emerson, Robert W; Herr, Hugh M

    2015-01-01

    Traditionally, prosthetic leg research has focused on improving mobility for activities of daily living. Artistic expression such as dance, however, is not a common research topic and consequently prosthetic technology for dance has been severely limited for the disabled. This work focuses on investigating the ankle joint kinetics and kinematics during a Latin-American dance to provide unique motor options for disabled individuals beyond those of daily living. The objective of this study was to develop a control system for a bionic ankle prosthesis that outperforms conventional prostheses when dancing the rumba. The biomechanics of the ankle joint of a non-amputee, professional dancer were acquired for the development of the bionic control system. Subsequently, a professional dancer who received a traumatic transtibial amputation in April 2013 tested the bionic dance prosthesis and a conventional, passive prosthesis for comparison. The ability to provide similar torque-angle behavior of the biological ankle was assessed to quantify the biological realism of the prostheses. The bionic dancing prosthesis overlapped with 37 ± 6% of the non-amputee ankle torque and ankle angle data, compared to 26 ± 2% for the conventional, passive prosthesis, a statistically greater overlap (p = 0.01). This study lays the foundation for quantifying unique, expressive activity modes currently unavailable to individuals with disabilities. Future work will focus on an expansion of the methods and types of dance investigated in this work.

  15. Correlation analysis between the interface membrane and loose hip prosthesis

    Institute of Scientific and Technical Information of China (English)

    Jian-bing Ma; Yu-ming Zhang; Xiang-dong Meng; Miao Liu

    2009-01-01

    Objective To analyze the cause of prosthesis loosening by observing the interface membranes harvested during the hip restoration operation. Methods A total of 28 specimens of interface membrane around the loose prosthesis were harvested from 28 patients undergoing the restoration of total hip replacement. All the specimens underwent the observation of appearance, light microscopy and scanning electronic microscopy(SEM). Results All the gaps around the loose prosthesis were filled with interface membrane of different thickness. The color of the most interface membrane was madder red, and the other one third of membrane was black. The comparatively thicker membrane was similar to scar connective tissue while the thinner was similar to fiber membrane. A large number of wear debris, macrophages and foreign-body giant cells were found under light microscope. With SEM observation a large number of different diameter collagen fibra structures that looked like scar tissues were arranged disorderly in a great mass, foreign particles and bone debris of different size were distributed unevenly, and the fibroblast was distributed in the collagen fiber. Conclusion Wear debris is related to inflammatory cell response around the interface membrane of the loose prosthesis. The wear debris engulfed by macrophage stimulates the interface membrane to release bone resorption factors (such as TNF) which lead to osteolysis, and this is one of the most important causes of the prosthesis loosening.

  16. A digital patient for computer-aided prosthesis design.

    Science.gov (United States)

    Colombo, Giorgio; Facoetti, Giancarlo; Rizzi, Caterina

    2013-04-06

    This article concerns the design of lower limb prosthesis, both below and above knee. It describes a new computer-based design framework and a digital model of the patient around which the prosthesis is designed and tested in a completely virtual environment. The virtual model of the patient is the backbone of the whole system, and it is based on a biomechanical general-purpose model customized with the patient's characteristics (e.g. anthropometric measures). The software platform adopts computer-aided and knowledge-guided approaches with the goal of replacing the current development process, mainly hand made, with a virtual one. It provides the prosthetics with a set of tools to design, configure and test the prosthesis and comprehends two main environments: the prosthesis modelling laboratory and the virtual testing laboratory. The first permits the three-dimensional model of the prosthesis to be configured and generated, while the second allows the prosthetics to virtually set up the artificial leg and simulate the patient's postures and movements, validating its functionality and configuration. General architecture and modelling/simulation tools for the platform are described as well as main aspects and results of the experimentation.

  17. Split-Framework in Mandibular Implant-Supported Prosthesis

    Directory of Open Access Journals (Sweden)

    Danny Omar Mendoza Marin

    2015-01-01

    Full Text Available During oral rehabilitation of an edentulous patient with an implant-supported prosthesis, mandibular flexure must be considered an important biomechanical factor when planning the metal framework design, especially if implants are installed posterior to the interforaminal region. When an edentulous mandible is restored with a fixed implant-supported prosthesis connected by a fixed full-arch framework, mandibular flexure may cause needless stress in the overall restorative system and lead to screw loosening, poor fit of prosthesis, loss of the posterior implant, and patient’s discomfort due to deformation properties of the mandible during functional movements. The use of a split-framework could decrease the stress with a precise and passive fit on the implants and restore a more natural functional condition of the mandible, helping in the longevity of the prosthesis. Therefore, the present clinical report describes the oral rehabilitation of an edentulous patient by a mandibular fixed implant-supported prosthesis with a split-framework to compensate for mandibular flexure. Clinical Significance. The present clinical report shows that the use of a split-framework reduced the risk of loss of the posterior implants or screws loosening with acceptable patient comfort over the period of a year. The split-framework might have compensated for the mandibular flexure during functional activities.

  18. Maxillary cement retained implant supported monolithic zirconia prosthesis in a full mouth rehabilitation: a clinical report

    OpenAIRE

    Sadid-Zadeh, Ramtin; Liu, Perng-Ru; Aponte-Wesson, Ruth; O'Neal, Sandra J

    2013-01-01

    This clinical report presents the reconstruction of a maxillary arch with a cement retained implant supported fixed prosthesis using a monolithic zirconia generated by CAD/CAM system on eight osseointegrated implants. The prosthesis was copy milled from an interim prosthesis minimizing occlusal adjustments on the definitive prosthesis at the time of delivery. Monolithic zirconia provides high esthetics and reduces the number of metal alloys used in the oral cavity.

  19. Maxillary cement retained implant supported monolithic zirconia prosthesis in a full mouth rehabilitation: a clinical report.

    Science.gov (United States)

    Sadid-Zadeh, Ramtin; Liu, Perng-Ru; Aponte-Wesson, Ruth; O'Neal, Sandra J

    2013-05-01

    This clinical report presents the reconstruction of a maxillary arch with a cement retained implant supported fixed prosthesis using a monolithic zirconia generated by CAD/CAM system on eight osseointegrated implants. The prosthesis was copy milled from an interim prosthesis minimizing occlusal adjustments on the definitive prosthesis at the time of delivery. Monolithic zirconia provides high esthetics and reduces the number of metal alloys used in the oral cavity.

  20. Application of Taguchi method in optimization of cervical ring cage.

    Science.gov (United States)

    Yang, Kai; Teo, Ee-Chon; Fuss, Franz Konstantin

    2007-01-01

    The Taguchi method is a statistical approach to overcome the limitation of the factorial and fractional factorial experiments by simplifying and standardizing the fractional factorial design. The objective of the current study is to illustrate the procedures and strengths of the Taguchi method in biomechanical analysis by using a case study of a cervical ring cage optimization. A three-dimensional finite element (FE) model of C(5)-C(6) with a generic cervical ring cage inserted was modelled. Taguchi method was applied in the optimization of the cervical ring cage in material property and dimensions for producing the lowest stress on the endplate to reduce the risk of cage subsidence, as in the following steps: (1) establishment of objective function; (2) determination of controllable factors and their levels; (3) identification of uncontrollable factors and test conditions; (4) design of Taguchi crossed array layout; (5) execution of experiments according to trial conditions; (6) analysis of results; (7) determination of optimal run; (8) confirmation of optimum run. The results showed that a cage with larger width, depth and wall thickness can produce the lower von Mises stress under various conditions. The contribution of implant materials is found trivial. The current case study illustrates that the strengths of the Taguchi method lie in (1) consistency in experimental design and analysis; (2) reduction of time and cost of experiments; (3) robustness of performance with removing the noise factors. The Taguchi method will have a great potential application in biomechanical field when factors of the issues are at discrete level.

  1. The theory of the bird-cage resonator

    Science.gov (United States)

    Tropp, James

    Circuit equations for the low-pass bird-cage resonator are solved to yield a two-parameter expression for the resonant frequencies; good agreement with experiment is shown for a bird cage of eight meshes. A theory of the driven bird-cage coil is given, which describes capacitive or inductive drive schemes, neglecting perturbations of coil symmetry due to the drive reactance. The theory shows how the polarization plane of the B field of a perfectly symmetrical bird cage can be rotated arbitrarily about the resonator's cylinder axis. Deviations from ideal symmetry, due to imperfect construction or trimming reactances, are then treated by perturbation theory. It is shown that in first order, the perturbation does not disturb the sinusoidal current distribution of the bird cage, although it does polarize that distribution along a direction fixed by the positions of the perturbing elements. The measured and calculated polarization directions are shown to agree to within experimental error; the measured frequency shifts due to perturbation are within 10% of those calculated. It is shown that two identical perturbations in space quadrature produce eigenstates with no spatial polarization, i.e., circularly traveling current waves.

  2. PROBLEMS OF BIOFOULING ON FISH–CAGE NETS IN AQUACULTURE

    Directory of Open Access Journals (Sweden)

    Merica Slišković

    2002-09-01

    Full Text Available Biofouling on fish–cage netting is a serious technical and economical problem to aquaculture worldwide. Compensation for the effects of biofouling must be included in cage system design and planning, as fouling can dramatically increase both weight and drag. Settlements of sessile plants and animals, with accumulation of the detritus diminish the size of mesh and can rapidly occlude mesh. Negative effect of smaller mesh size is changing in water flow trough the cages. Biofouling problems necessitating purchase of a second sets of nets or more, and frequent cleaning and changing of biofouling. Changing and cleaning frequency depend on many factors such as: location of cages (near the coast or off shore, productivity of that location, time of the year, time period in which the cages are placed on that location (cause of loading of phosphorus and nitrogen from the unconsumed food in the sediment. Net changing and cleaning procedures are labor and capital intensive. Process of the cleaning of the nets is inadequate, especially when there isnžt adequate equipment available as it is case in smaller aquaculture industry. Chemical control of biofouling e. g. use of antifoulants is questioningly cause of their possible negative effects on breeding species and environment.

  3. High levitation pressures with cage-cooled superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Hull, John R. [Energy Technology Division, Argonne National Laboratory, Argonne, IL (United States); Komori, Mochimitsu [Department of Mechanical Systems Engineering, Kyushu Institute of Technology, Iizuka, Fukuoka (Japan)

    2002-05-01

    We present an analysis of and experimental results from a levitational system comprising a stationary, bulk high-temperature superconductor (HTS) and a levitated component (rotor) that consists of a cylindrical permanent magnet surrounded by an annular HTS. The rotor is cooled below the critical temperature of the HTS while surrounded by a ferromagnetic cage. When the ferromagnetic cage is removed, the flux from the permanent magnet is essentially excluded from the interior of the HTS. When brought into proximity with the HTS stator, the cage-cooled rotor experiences a levitational force. The levitational force may be calculated by applying magnetic circuit theory. Such calculations indicate that for a sufficiently high critical current density, the levitational pressure may exceed that between the permanent magnet and its mirror image. We constructed a rotor from an NdFeB permanent magnet and YBCO bulk HTS with a critical current density of {approx}5 kA cm{sup -2}. A soft ferromagnetic steel cage was constructed in segments. The critical current density of the stator HTS was also {approx}5 kA cm{sup -2}. Experimental results obtained with the cage-cooled rotor and stationary HTS show a significant increase in force over that of an equivalent PM rotor and stationary HTS. (author)

  4. High levitation pressures with cage-cooled superconductors

    Science.gov (United States)

    Hull, John R.; Komori, Mochimitsu

    2002-05-01

    We present an analysis of and experimental results from a levitational system comprising a stationary, bulk high-temperature superconductor (HTS) and a levitated component (rotor) that consists of a cylindrical permanent magnet surrounded by an annular HTS. The rotor is cooled below the critical temperature of the HTS while surrounded by a ferromagnetic cage. When the ferromagnetic cage is removed, the flux from the permanent magnet is essentially excluded from the interior of the HTS. When brought into proximity with the HTS stator, the cage-cooled rotor experiences a levitational force. The levitational force may be calculated by applying magnetic circuit theory. Such calculations indicate that for a sufficiently high critical current density, the levitational pressure may exceed that between the permanent magnet and its mirror image. We constructed a rotor from an NdFeB permanent magnet and YBCO bulk HTS with a critical current density of ≈5 kA cm-2. A soft ferromagnetic steel cage was constructed in segments. The critical current density of the stator HTS was also ≈5 kA cm-2. Experimental results obtained with the cage-cooled rotor and stationary HTS show a significant increase in force over that of an equivalent PM rotor and stationary HTS.

  5. 21 CFR 888.3100 - Ankle joint metal/composite semi-constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... cemented prosthesis. 888.3100 Section 888.3100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Ankle joint metal/composite semi-constrained cemented prosthesis. (a) Identification. An ankle joint metal/composite semi-constrained cemented prosthesis is a device intended to be implanted to replace...

  6. 21 CFR 888.3400 - Hip joint femoral (hemi-hip) metallic resurfacing prosthesis.

    Science.gov (United States)

    2010-04-01

    ... prosthesis. 888.3400 Section 888.3400 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... femoral (hemi-hip) metallic resurfacing prosthesis. (a) Identification. A hip joint femoral (hemi-hip) metallic resurfacing prosthesis is a device intended to be implanted to replace a portion of the hip...

  7. 21 CFR 888.3790 - Wrist joint metal constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Wrist joint metal constrained cemented prosthesis... constrained cemented prosthesis. (a) Identification. A wrist joint metal constrained cemented prosthesis is a... as cobalt-chromium-molybdenum, and is limited to those prostheses intended for use with bone...

  8. 21 CFR 888.3170 - Elbow joint radial (hemi-elbow) polymer prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Elbow joint radial (hemi-elbow) polymer prosthesis... (hemi-elbow) polymer prosthesis. (a) Identification. An elbow joint radial (hemi-elbow) polymer prosthesis is a device intended to be implanted made of medical grade silicone elastomer used to replace...

  9. 21 CFR 888.3220 - Finger joint metal/polymer constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... prosthesis. 888.3220 Section 888.3220 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... metal/polymer constrained cemented prosthesis. (a) Identification. A finger joint metal/polymer constrained cemented prosthesis is a device intended to be implanted to replace a metacarpophalangeal...

  10. 21 CFR 888.3690 - Shoulder joint humeral (hemi-shoulder) metallic uncemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... uncemented prosthesis. 888.3690 Section 888.3690 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Shoulder joint humeral (hemi-shoulder) metallic uncemented prosthesis. (a) Identification. A shoulder joint humeral (hemi-shoulder) metallic uncemented prosthesis is a device made of alloys, such as...

  11. 21 CFR 888.3210 - Finger joint metal/metal constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... prosthesis. 888.3210 Section 888.3210 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... metal/metal constrained cemented prosthesis. (a) Identification. A finger joint metal/metal constrained cemented prosthesis is a device intended to be implanted to replace a metacarpophalangeal (finger)...

  12. 21 CFR 888.3370 - Hip joint (hemi-hip) acetabular metal cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... prosthesis. 888.3370 Section 888.3370 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... (hemi-hip) acetabular metal cemented prosthesis. (a) Identification. A hip joint (hemi-hip) acetabular metal cemented prosthesis is a device intended to be implanted to replace a portion of the hip...

  13. 21 CFR 888.3350 - Hip joint metal/polymer semi-constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... prosthesis. 888.3350 Section 888.3350 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... metal/polymer semi-constrained cemented prosthesis. (a) Identification. A hip joint metal/polymer semi-constrained cemented prosthesis is a device intended to be implanted to replace a hip joint. The device...

  14. 21 CFR 888.3760 - Wrist joint carpal scaphoid polymer prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Wrist joint carpal scaphoid polymer prosthesis. 888.3760 Section 888.3760 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... scaphoid polymer prosthesis. (a) Identification. A wrist joint carpal scaphoid polymer prosthesis is a...

  15. 21 CFR 888.3800 - Wrist joint metal/polymer semi-constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... cemented prosthesis. 888.3800 Section 888.3800 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Wrist joint metal/polymer semi-constrained cemented prosthesis. (a) Identification. A wrist joint metal/polymer semi-constrained cemented prosthesis is a device intended to be implanted to replace a wrist...

  16. 21 CFR 888.3300 - Hip joint metal constrained cemented or uncemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... prosthesis. 888.3300 Section 888.3300 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... metal constrained cemented or uncemented prosthesis. (a) Identification. A hip joint metal constrained cemented or uncemented prosthesis is a device intended to be implanted to replace a hip joint. The...

  17. 21 CFR 888.3770 - Wrist joint carpal trapezium polymer prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Wrist joint carpal trapezium polymer prosthesis. 888.3770 Section 888.3770 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... trapezium polymer prosthesis. (a) Identification. A wrist joint carpal trapezium polymer prosthesis is a...

  18. 21 CFR 888.3750 - Wrist joint carpal lunate polymer prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Wrist joint carpal lunate polymer prosthesis. 888.3750 Section 888.3750 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... lunate polymer prosthesis. (a) Identification. A wrist joint carpal lunate prosthesis is a...

  19. 21 CFR 888.3340 - Hip joint metal/composite semi-constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... cemented prosthesis. 888.3340 Section 888.3340 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Hip joint metal/composite semi-constrained cemented prosthesis. (a) Identification. A hip joint metal/composite semi-constrained cemented prosthesis is a two-part device intended to be implanted to replace...

  20. 21 CFR 888.3110 - Ankle joint metal/polymer semi-constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... cemented prosthesis. 888.3110 Section 888.3110 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Ankle joint metal/polymer semi-constrained cemented prosthesis. (a) Identification. An ankle joint metal/polymer semi-constrained cemented prosthesis is a device intended to be implanted to replace an...

  1. 21 CFR 888.3360 - Hip joint femoral (hemi-hip) metallic cemented or uncemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... uncemented prosthesis. 888.3360 Section 888.3360 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Hip joint femoral (hemi-hip) metallic cemented or uncemented prosthesis. (a) Identification. A hip joint femoral (hemi-hip) metallic cemented or uncemented prosthesis is a device intended to be...

  2. 21 CFR 888.3680 - Shoulder joint glenoid (hemi-shoulder) metallic cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... cemented prosthesis. 888.3680 Section 888.3680 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Shoulder joint glenoid (hemi-shoulder) metallic cemented prosthesis. (a) Identification. A shoulder joint glenoid (hemi-shoulder) metallic cemented prosthesis is a device that has a glenoid (socket)...

  3. 21 CFR 888.3160 - Elbow joint metal/polymer semi-constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... cemented prosthesis. 888.3160 Section 888.3160 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Elbow joint metal/polymer semi-constrained cemented prosthesis. (a) Identification. An elbow joint metal/polymer semi-constrained cemented prosthesis is a device intended to be implanted to replace an...

  4. 21 CFR 888.3180 - Elbow joint humeral (hemi-elbow) metallic uncemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... uncemented prosthesis. 888.3180 Section 888.3180 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Elbow joint humeral (hemi-elbow) metallic uncemented prosthesis. (a) Identification. An elbow joint humeral (hemi-elbow) metallic uncemented prosthesis is a device intended to be implanted made of...

  5. 21 CFR 888.3120 - Ankle joint metal/polymer non-constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... prosthesis. 888.3120 Section 888.3120 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... metal/polymer non-constrained cemented prosthesis. (a) Identification. An ankle joint metal/polymer non-constrained cemented prosthesis is a device intended to be implanted to replace an ankle joint. The...

  6. 21 CFR 888.3660 - Shoulder joint metal/polymer semi-constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... cemented prosthesis. 888.3660 Section 888.3660 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Shoulder joint metal/polymer semi-constrained cemented prosthesis. (a) Identification. A shoulder joint metal/polymer semi-constrained cemented prosthesis is a device intended to be implanted to replace...

  7. 21 CFR 888.3200 - Finger joint metal/metal constrained uncemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... prosthesis. 888.3200 Section 888.3200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... metal/metal constrained uncemented prosthesis. (a) Identification. A finger joint metal/metal constrained uncemented prosthesis is a device intended to be implanted to replace a metacarpophalangeal...

  8. 78 FR 79308 - Dental Devices; Reclassification of Temporary Mandibular Condyle Prosthesis

    Science.gov (United States)

    2013-12-30

    ... Temporary Mandibular Condyle Prosthesis AGENCY: Food and Drug Administration, HHS. ACTION: Final order... mandibular condyle prosthesis, a preamendments class III device, into class II (special controls), and rename... section 513(b) of the FD&C Act with respect to temporary mandibular condyle prosthesis (the 1997...

  9. 21 CFR 888.3310 - Hip joint metal/polymer constrained cemented or uncemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... uncemented prosthesis. 888.3310 Section 888.3310 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Hip joint metal/polymer constrained cemented or uncemented prosthesis. (a) Identification. A hip joint metal/polymer constrained cemented or uncemented prosthesis is a device intended to be implanted...

  10. Changes in performance over time while learning to use a myoelectric prosthesis

    NARCIS (Netherlands)

    Bouwsema, Hanneke; van der Sluis, Corry K.; Bongers, Raoul M.

    2014-01-01

    Background: Training increases the functional use of an upper limb prosthesis, but little is known about how people learn to use their prosthesis. The aim of this study was to describe the changes in performance with an upper limb myoelectric prosthesis during practice. The results provide a basis t

  11. A short-term study in sheep with the Groningen temporomandibular joint prosthesis

    NARCIS (Netherlands)

    van Loon, JP; de Bont, LGM; Spijkervet, FKL; Verkerke, GJ; Liem, RSB

    2000-01-01

    As part of the pre-clinical testing process of a newly developed temporomandibular joint (TMJ) prosthesis, animal experiments were performed. In 14 sheep, the right TMJ was replaced by the developed TMJ prosthesis. The prosthesis consisted of a skull part, a mandibular part and an intervening polyet

  12. Research, design & development project Myoelectric Prosthesis of Upper Limb

    Science.gov (United States)

    Galiano, L.; Montaner, E.; Flecha, A.

    2007-11-01

    A Research Design and Development Project was developed of a myoelectric prosthesis for a pediatric patient presenting congenital amputation of the left forearm below the elbow. A multidisciplinary work-team was formed for this goal, in order to solve the several (/various) aspects regarding this project (mechanical, ergonomics, electronics, physical). The prosthesis as an electromechanical device was divided in several blocks, trying to achieve a focused development for each stage, acording to requisites. A mechanical prototype of the prothesis was designed and built along with the circuitry needed for EMG aquisition, control logic and drivers. Having acomplished the previuos stages, the project is now dealing with the definitions of the interface between the prosthesis and the patient, with promising perspectives.

  13. Preliminary functional assessment of a multigrasp myoelectric prosthesis.

    Science.gov (United States)

    Dalley, Skyler A; Bennett, Daniel A; Goldfarb, Michael

    2012-01-01

    The authors have previously described a multigrasp hand prosthesis prototype, and a two-site surface EMG based multigrasp control interface for its control. In this paper, the authors present a preliminary assessment of the efficacy of the prosthesis and multigrasp controller in performing tasks requiring interaction and manipulation. The authors use as a performance measure the Southampton Hand Assessment Procedure (SHAP), which entails manipulation of various objects designed to emulate activities of daily living, and provides a set of scores that indicate level of functionality in various types of hand function. In this preliminary assessment, a single non-amputee subject performed the SHAP while wearing the multigrasp prosthesis via an able-bodied adaptor. The results from this testing are presented, and compared to recently published SHAP results obtained with commercially available single-grasp and multigrasp prosthetic hands.

  14. Nasal prosthesis for a patient with xeroderma pigmentosum

    Science.gov (United States)

    Kumar, Suresh; Rajtilak, G.; Rajasekar, V.; Kumar, Muthu

    2013-01-01

    Acquired facial defects caused by extirpation of neoplasms, congenital malformations or traumatic injury results in a huge functional, cosmetic and psychological handicap in those patients. These defects can be restored by facial prosthesis using different materials and retention methods to achieve a lifelike appearance and function. This clinical report describes a treatment schedule using silicone nasal prosthesis, which is mechanically retained for a patient who has undergone a partial rhinectomy due to basal cell carcinoma of the nose. The prosthesis was made to restore the esthetic appearance of patient with a mechanically retained design using a spectacle glass frame without any prosthetic adhesives so that the patient is more comfortable and confident to resume daily activities. PMID:23956602

  15. Komposit Laminate Rami Epoksi Sebagai Bahan Alternatif Socket Prosthesis

    Directory of Open Access Journals (Sweden)

    Agustinus P. Irawan

    2009-01-01

    Full Text Available pure plant oil, biofuel, coconut oil, palm oil, jatropha oilSocket is the most important component in a prosthesis making. Performance criteria for prosthetic socket material include strength, durability, minimal weight, comfort, and minimal fabrication cost. This research attempts to analyze the strength of ramie fiber reinforced epoxy laminate composite as an alternative of socket prosthesis. The research based on ASTM D 3039/D 3039M for tensile strength and ASTM D 695 for compressive strength. The ramie fiber used was a continuous fiber 100 % Ne14'S, with Epoxy Resin Bakelite EPR 174 and Epoxy Hardener V-140. The sample test was created using a hand lay-up method. The result of this research is presented in a correlation of finsile strength (st, compression strength (sc, elasticity modulus (E versus fraction volume of fiber (Vf. The result is then being compared with some of the prosthesis material’s strength produced by Otto Bock. The analysis was completed with the mode of the failure observation by using Scanning Electron Microscope (SEM. The result concludes that the ramie fiber reinforced epoxy laminate composite is potentially developed further as a socket prosthesis material on Vf 40 – 50 %. Tensile strength and specific strength that has been generated was higher than that of several materias for socket prosthesis, including fiberglass. The mode of the failure found were a brittle failure on Vf: 10-30%, debonding and delamination on Vf: 40-50%. Abstract in Bahasa Indonesia: Socket merupakan bagian terpenting dalam pembuatan prosthesis. Kriteria bahan socket prosthesis antara lain kekuatan, ketahanan, ringan, kenyamanan dan biaya produksi yang rendah. Penelitian ini bertujuan menganalisis kekuatan komposit laminate berpenguat serat rami epoksi sebagai bahan alternatif socket prosthesis. Pengujian kekuatan mengacu standar ASTM D 3039/D 3039M uji tarik dan ASTM D 695 uji tekan. Serat rami yang digunakan berupa serat kontinyu jenis

  16. [Tests of hand functionality in upper limb amputation with prosthesis].

    Science.gov (United States)

    Bazzini, G; Orlandini, D; Moscato, T A; Nicita, D; Panigazzi, M

    2007-01-01

    The need for standardized instruments for clinical measurements has become pressing in the fields of occupational rehabilitation and ergonomics. This is particularly the case for instruments that allow a quantitative evaluation of upper limb function, and especially hand function in patients who have undergone an amputation and then application of an upper limb prosthesis. This study presents a review of the main tests used to evaluate hand function, with a critical analysis of their use in subjects with an upper limb prosthesis. The tests are divided into: tests to evaluate strength, tests to evaluate co-ordination and dexterity, tests of global or overall function, and tests proposed specifically for subjects with an upper limb prosthesis. Of the various tests presented, the authors give their preference to the Bimanual Functional Assessment, Abilhand and/or the ADL Questionnaire, because of the practical usefulness, clinimetric features, simplicity and ease of administration of these tests.

  17. An electronic prosthesis mimicking the dynamic vestibular function

    Science.gov (United States)

    Shkel, Andrei M.

    2006-03-01

    This paper reports our progress toward development of a unilateral vestibular prosthesis. The sensing element of the prosthesis is a custom designed one-axis MEMS gyroscope. Similarly to the natural semicircular canal, the microscopic gyroscope senses angular motion of the head and generates voltages proportional to the corresponding angular accelerations. Then, voltages are sent to the pulse generating unit where angular motion is translated into voltage pulses. The voltage pulses are converted into current pulses and are delivered through specially designed electrodes, conditioned to stimulate the corresponding vestibular nerve branch. Our preliminary experimental evaluations of the prosthesis on a rate table indicate that the device's output matches the average firing rate of vestibular neurons to those in animal models reported in the literature. The proposed design is scalable; the sensing unit, pulse generator, and the current source can be potentially implemented on a single chip using integrated MEMS technology.

  18. Comparison of Titanium vs. Polycel Total Ossicular Replacement Prosthesis

    Directory of Open Access Journals (Sweden)

    Mohammad Faramarzi

    2016-01-01

    Full Text Available Introduction: Even though modern technology progresses so rapidly, annals of otology are replete with so many challenging article, which often compare various types of prosthesis. Since there has not been a prospective randomized clinical trial study which compares the hearing result of total ossicular replacement prosthesis made of Titanium with omega connector and Polycel in the literature, we decided to perform a study encompassing this issue.   Materials and Methods: 105 patients, who were in the 2nd stage of their operation and who needed total ossicular replacement prosthesis, were included in this prospective single blind randomized clinical trial study. Patients were classified in two groups: titanium Kurz (TTP™ -Vario system, Kurz GmbH, Dusslingen, Germany with omega connector and Polycel (Sheehy Plastipore Polycel, Medtronic Xomed Inc. The duration of the follow up was 6-12 months. In order to evaluate hearing results, pure tone audiometric in 0.5, 1, 2, and 4 kHz were checked. In addition, speech reception threshold was recorded. A successful surgery was defined as having a postoperative air–bone gap within 20 dB.   Results: We accomplished successful hearing in 64.4% of patients with titanium and 65% of patients with a Polycel prosthesis.Improvement in speech reception threshold was 11.5 dB in the titanium group and 13 dB in the Polycel group. In other words, there was no significant difference between the two groups. In addition, air-bone gap improvement after ossiculoplasty was 11.2 dB in the patients with a titanium prosthesis and 12.4 dB in the Polycel group. In fact, the difference was not significant.   Conclusion: We found that both the titanium and the Polycel prosthesis improve speech reception threshold and air-bone gap closure in a similar manner.

  19. A laboratory cage for foster nursing newborn mice

    Directory of Open Access Journals (Sweden)

    S. Marques-de-Araújo

    1999-03-01

    Full Text Available We describe a cage to be used for foster nursing in order to guarantee that original mother's colostrum is not ingested by the newborn mice. A common (30.5 cm x 19.5 cm x 12.0 cm mouse cage was fitted with a wire net tray with a mesh (1 cm x 1 cm, which divides the cage into an upper and a lower compartment. Mice born to females placed in the upper compartment pass through the mesh and fall into the lower compartment, where another lactating female with one or two of its own pups are. Of a total of 28 newborn mice of C3H/He and Swiss strains, 23 were successfully fostered. Important observations are presented to show that this is a valuable alternative for foster studies without great suffering on the part of the female.

  20. [Ankle joint prosthesis for bone defects].

    Science.gov (United States)

    Lampert, C

    2011-11-01

    Large defects of the talus, i.e. due to tumors, large areas of osteolysis in total ankle replacement (TAR) and posttraumatic talus body necrosis are difficult to manage. The gold standard in these circumstances is still tibiocalcaneal arthrodesis with all the negative aspects of a completely rigid hindfoot. We started 10 years ago to replace the talus by a custom-made, all cobalt-chrome implant (laser sintering). The first patient with a giant cell tumor did very well but the following patients showed all subsidence of the metal talus into the tibia due to missing bony edges. Therefore, we constructed a custom-made talus (mirrored from the healthy side) and combined it with a well functioning total ankle prosthesis (Hintegra). So far we have implanted this custom-made implant into 3 patients: the first had a chondrosarcoma of the talus (1 year follow-up), the second had massive osteolysis/necrosis of unknown origin (6 months follow-up) and the third massive osteolysis following a correct TAR (2 months follow-up). The results are very encouraging as all of the patients are practically pain free and have a good range of movement (ROM): D-P flexion 15°-0-20° but less motion in the lower ankle joint: ROM P-S 5°-0-5°. No subsidence was detected in the tibia or the calcaneus. The custom-made talus combined with the Hintegra total ankle replacement will probably be an interesting alternative to a tibiocalcaneal arthrodesis in selected cases with massive defects of the talus.

  1. Heterotopic ossification associated with myelopathy following cervical disc prosthesis implantation.

    Science.gov (United States)

    Wenger, Markus; Markwalder, Thomas-Marc

    2016-04-01

    This case report presents a 37-year-old man with clinical signs of myelopathy almost 9 years after implantation of a Bryan disc prosthesis (Medtronic Sofamor Danek, Memphis, TN, USA) for C5/C6 soft disc herniation. As demonstrated on MRI and CT scan, spinal cord compression was caused by bony spurs due to heterotopic ossification posterior to the still moving prosthesis. The device, as well as the ectopic bone deposits, had to be removed because of myelopathy and its imminent aggravation. Conversion to anterior spondylodesis was performed.

  2. Improving esthetics of finger prosthesis by glove silicone

    Directory of Open Access Journals (Sweden)

    Laxman Singh Kaira

    2014-01-01

    Full Text Available Finger and partial finger amputations are some of the most frequently encountered forms of partial hand loss. A high quality esthetic prosthesis with passive function can be helpful to the patient since loss or congenital absence or malformation have both a social and psychological impact on the patient. Prosthetics is an art and science, which provides lifelike appearance to the lost structures of the patient. This case report presents the fabrication of a silicone finger prosthesis, which had good suspension, adequate function, was comfortable to use and esthetically acceptable to the patient.

  3. [Prosthetic treatment of mandibular pseudarthrosis using an articulated prosthesis].

    Science.gov (United States)

    Sidibe, C A; Razouk, O; Dichamp, J; Bertrand, J C; Vaillant, J M

    1994-01-01

    Two cases with complete loss of the tooth-bearing portion of the mandible were repaired with a prosthesis. This type of defect can involve the loss of a large number of teeth and aggression to the remaining teeth must be limited as much as possible. A two-part "articulated" prosthesis with two rings appears to be the best adapted system. This method takes into account the requirements of for additional conventional prostheses and thus makes it possible to save the remaining teeth.

  4. Design and characterization of a powered elbow prosthesis.

    Science.gov (United States)

    Bennett, Daniel A; Mitchell, Jason; Goldfarb, Michael

    2015-01-01

    This paper describes the design of a powered elbow prosthesis, which incorporates a belt and cable drive transmission with a brushless DC motor to achieve an output torque of approximately 18.4 Nm, a backdrive torque of 1.5 Nm, and a speed of up to 360 deg/s while remaining within the anthropomorphic envelope with regard to mass and size. The measured torque and speed of the prosthesis is commensurate with nominal capability of the natural limb (for purposes of performing activities of daily living).

  5. Aspiration of tracheoesophageal prosthesis in a laryngectomized patient

    Directory of Open Access Journals (Sweden)

    Conte Sergio C

    2012-08-01

    Full Text Available Abstract Background The voice prosthesis inserted into a tracheoesophageal fistula has become the most widely used device for voice rehabilitation in patients with total laryngectomy. Case presentation We describe a case of tracheoesophageal prosthesis’ (TEP aspiration in a laryngectomized patient, with permanent tracheal stoma, that appeared during standard cleaning procedure, despite a programme of training for the safe management of patients with voice prosthesis. Conclusions The definitive diagnosis and treatment were performed by flexible bronchoscopy, that may be considered the procedure of choice in these cases, also on the basis of the literature.

  6. A Post-Functionalizable Iso-Polyoxotitanate Cage Cluster.

    Science.gov (United States)

    Hou, Jie; Hu, Junyi; Sun, Qing; Zhang, Guanyun; Tung, Chen-Ho; Wang, Yifeng

    2016-07-18

    During solvothermal alcoholysis of a mixture of TiI4 and Ti(O(i)Pr)4, a {I@Ti22} cage cluster encapsulating an OH and iodide guests is crystallized. The {I@Ti22} host-guest cluster surface is postfunctionalizable with catecholate and carboxylate ligands. The synthetic details, structural characterization, spectroscopic properties of the obtained cages clusters are provided. The present study provides candidates for modeling ligand exchange and electron-hole transfer at the titanate nanoparticle surface, and meanwhile offers new opportunities for understanding the TiO2 nanocrystalline formation in solvothermal processes.

  7. Equivalence Between Squirrel Cage and Sheet Rotor Induction Motor

    Science.gov (United States)

    Dwivedi, Ankita; Singh, S. K.; Srivastava, R. K.

    2016-06-01

    Due to topological changes in dual stator induction motor and high cost of its fabrication, it is convenient to replace the squirrel cage rotor with a composite sheet rotor. For an experimental machine, the inner and outer stator stampings are normally available whereas the procurement of rotor stampings is quite cumbersome and is not always cost effective. In this paper, the equivalence between sheet/solid rotor induction motor and squirrel cage induction motor has been investigated using layer theory of electrical machines, so as to enable one to utilize sheet/solid rotor in dual port experimental machines.

  8. Numerical Simulation of Hydrodynamic Behaviors of Gravity Cage in Waves

    Institute of Scientific and Technical Information of China (English)

    ZHAO Yun-peng; LI Yu-cheng; DONG Guo-hai; GUI Fu-kun

    2007-01-01

    This paper aims at investigation of the dynamic properties of gravity cage exposed to waves by use of a numerical model. The numerical model is developed, based on lumped mass method to set up the equations of motion of the whole cage; meanwhile the solutions of equations are solved by the Runge-Kutta-Verner fifth-order and sixth-order method. Physical model tests have been carried out to examine the validity of the numerical model. The results by the numerical simulation agree well with the experimental data.

  9. Mice Do Not Habituate to Metabolism Cage Housing

    DEFF Research Database (Denmark)

    Kalliokoski, Otto; Jacobsen, Kirsten Rosenmaj; Darusman, Huda Shalahudin;

    2013-01-01

    state of the mice also indicated impaired well-being in the metabolism cage housed mice. However, monitoring body weight and feed intake was found misleading in assessing the wellbeing of mice over a longer time course, and the forced swim test was found poorly suited for studying chronic stress in mice...... of abnormality were monitored. Forced swim tests were conducted to determine whether the animals experienced behavioral despair and the serotonergic integrity was tested using an 8-OH-DPAT challenge. The metabolism cage housed mice excreted approximately tenfold higher amounts of corticosterone metabolites...

  10. Quantum collision states for positive charges in an octahedral cage

    CERN Document Server

    Mendes, R V

    2003-01-01

    One-electron energy levels are studied for a configuration of two positive charges inside an octahedral cage, the vertices of the cage being occupied by atoms with a partially filled shell. Although ground states correspond to large separations, there are relatively low-lying states with large collision probabilities. Electromagnetic radiation fields used to excite the quantum collisional levels may provide a means to control nuclear reactions. However, given the scale of the excitation energies involved, this mechanism cannot provide an explanation for the unexplained ``cold fusion'' events.

  11. Caged DNA does not aggregate in high ionic strength solutions.

    Science.gov (United States)

    Trubetskoy, V S; Loomis, A; Slattum, P M; Hagstrom, J E; Budker, V G; Wolff, J A

    1999-01-01

    The assembly of DNA into compact particles that do not aggregate in physiologic salt solution occurs naturally in chromatin and viral particles but has been challenging to duplicate using artificial constructs. Cross-linking amino-containing polycations in the presence of DNA with bisimidoester cross-linker leads to the formation of caged DNA particles that are stable in salt solutions. This first demonstration of caged DNA provides insight into how natural condensation processes avoid aggregation and a promising avenue for developing nonviral gene therapy vectors.

  12. Penile prosthesis implantation in the era of medical treatment for erectile dysfunction.

    Science.gov (United States)

    Montague, Drogo K

    2011-05-01

    Penile prosthesis implantation, the oldest of the modern treatments for erectile dysfunction (ED), still plays an important role despite the advent of less invasive alternatives. For some men with ED, penile prosthesis implantation is the only effective or acceptable treatment. Penile prosthesis implantation remains a viable option in the contemporary management of ED as evidenced by annual penile prosthesis implantation cases in the United States rising from 17,540 in 2000 to 22,420 in 2009. Improvements in prosthesis design and implantation techniques have resulted in significant increases in device survival and patient satisfaction.

  13. Percutaneous Revision of a Testicular Prosthesis is Safe, Cost-effective, and Provides Good Patient Satisfaction

    Directory of Open Access Journals (Sweden)

    Eugene B. Cone

    2015-09-01

    Full Text Available Office-based percutaneous revision of a testicular prosthesis has never been reported. A patient received a testicular prosthesis but was dissatisfied with the firmness of the implant. In an office setting, the prosthesis was inflated with additional fluid via a percutaneous approach. Evaluated outcomes included patient satisfaction, prosthesis size, recovery time, and cost savings. The patient was satisfied, with no infection, leak, or complication after more than 1 year of follow-up, at significantly less cost than revision surgery. Percutaneous adjustment of testicular prosthesis fill-volume can be safe, inexpensive, and result in good patient satisfaction.

  14. Management of long span partially edentulous maxilla with fixed removable denture prosthesis

    Directory of Open Access Journals (Sweden)

    Mahilan I Jeyavalan

    2012-01-01

    Full Text Available Restoration of a long span partially edentulous maxilla with tooth supported prosthesis is challenging because of inherent anatomic limitations and unfavourable biomechanics present after the loss of teeth. A tooth supported fixed-removable prosthesis is a treatment option for restoration of such long span partially edentulous maxillary arches. This prosthesis meets the requirements for esthetics, phonetics, comfort, and hygiene, as well as favourable biomechanical stress distribution to the remaining natural tooth abutments. This article presents a procedure for fabrication of a fixed-removable prosthesis that has cement-retained custom cast bar metal substructure and a ball attachment retained removable superstructure prosthesis.

  15. Rehabilitation of orbital defect with silicone orbital prosthesis retained by dental implants

    Science.gov (United States)

    Guttal, Satyabodh Shesharaj; Desai, Jhanvi; Kudva, Adarsh; Patil, Basavaraj R

    2016-01-01

    Orbital defects can result from cancer, birth anomalies, or trauma leading to an onslaught of problems in the function and psyche of the patient. These defects are restored by surgical reconstruction and followed by placement of orbital prosthesis for cosmetic makeup. The use of dental implants in retaining orbital prosthesis improves patient acceptance of the prosthesis owing to better retention and stability than conventional adhesive retained prosthesis. This case report describes a custom-made magnetic retentive assembly anchored by a dental implant which offers the orbital prosthesis the simplicity of self-alignment and ease of use. PMID:26953033

  16. [An obturator prosthesis in a patient with perfect dentition. Functional, esthetic approach].

    Science.gov (United States)

    Razouk, O; Sidibe, C A; Dichamp, J; Bertrand, J C

    1994-01-01

    A prosthesis was implanted immediately after operation for a velo-palatal tissue defect in an active young female patient in order to avoid function, psychological and social complications involved with this mutilation. The three classical steps of the process were performed: immediate implantation of the prosthesis, temporary prosthesis, definitive prosthesis. Anchoring to the teeth maintained the prosthesis in position. A functional print is always needed to obtain perfect closure. A metallic bridge links the retention part and the obstructive part. The device is effective, discrete, functional and well-tolerated by the patient.

  17. [Choice of hip prosthesis in patients younger than 50 years

    NARCIS (Netherlands)

    Schreurs, B.W.; Busch, V.J.; Veth, R.P.H.

    2007-01-01

    There is no agreement about the most ideal type of hip prosthesis to be used in patients younger than 50 years. The most commonly used hip prostheses in patients younger than 50 years are uncemented or resurfacing prostheses and to a lesser extent cemented prostheses. A good result of a hip prosthes

  18. Transfemoral prosthesis suspension systems: a systematic review of the literature.

    Science.gov (United States)

    Gholizadeh, Hossein; Abu Osman, Noor Azuan; Eshraghi, Arezoo; Ali, Sadeeq

    2014-09-01

    The purpose of this study was to find the scientific evidence pertaining to various transfemoral suspension systems to provide selection criteria for clinicians. To this end, databases of PubMed, Web of Science, and ScienceDirect were explored. The following key words, as well as their combinations and synonyms, were used for the search: transfemoral prosthesis, prosthetic suspension, lower limb prosthesis, above-knee prosthesis, prosthetic liner, transfemoral, and prosthetic socket. The study design, research instrument, sampling method, outcome measures, and protocols of articles were reviewed. On the basis of the selection criteria, 16 articles (11 prospective studies and 5 surveys) were reviewed. The main causes of reluctance to prosthesis, aside from energy expenditure, were socket-related problems such as discomfort, perspiration, and skin problems. Osseointegration was a suspension option, yet it is rarely applied because of several drawbacks, such as extended rehabilitation process, risk for fracture, and infection along with excessive cost. In conclusion, no clinical evidence was found as a "standard" system of suspension and socket design for all transfemoral amputees. However, among various suspension systems for transfemoral amputees, the soft insert or double socket was favored by most users in terms of function and comfort.

  19. Task-Oriented Gaming for Transfer to Prosthesis Use

    NARCIS (Netherlands)

    van Dijk, Ludger; Sluis, van der Corry K.; van Dijk, Hylke W.; Bongers, Raoul M.

    2016-01-01

    The aim of this study is to establish the effect of task-oriented video gaming on using a myoelectric prosthesis in a basic activity of daily life (ADL). Forty-one able-bodied right-handed participants were randomly assigned to one of four groups. In three of these groups the participants trained to

  20. Verge of Collapse: The Pros/thesis of Art Research

    Science.gov (United States)

    Garoian, Charles R.

    2008-01-01

    This article explores "prosthesis" as a metaphor of embodiment in art-based research to challenge the utopian myth of wholeness and normality in art and the human body. Bearing in mind the correspondences between amputated bodies and the cultural dislocations of art, I propose "prosthetic epistemology" and "prosthetic ontology" as embodied knowing…

  1. Intermanual transfer effects in below-elbow myoelectric prosthesis users

    NARCIS (Netherlands)

    de Boer, Errit; Romkema, Sietske; Cutti, Andrea G; Brouwers, Michael A H; Bongers, Raoul M; van der Sluis, Corry K

    2016-01-01

    OBJECTIVE: To determine intermanual transfer effects in patients with a below-elbow amputation using a myoelectric prosthesis, and to establish whether laterality affects these effects. DESIGN: Case-control. SETTING: A standardized setting in a rehabilitation clinic. PARTICIPANTS: A convenience samp

  2. [Medial unicompartmental knee prosthesis for patients with unicompartmental gonarthrosis

    NARCIS (Netherlands)

    Kort, N.P.; Deutman, R.; Raay, J.J. van; Horn, J.R. van

    2004-01-01

    The function and survival time of unicompartmental knee prostheses for patients with severe gonarthrosis have been improved the past few years by developments in their design, the instrumentarium and the surgical technique. A medial unicompartmental knee prosthesis may be indicated in patients with

  3. Transtibial prosthesis suspension failure during skydiving freefall: a case report.

    Science.gov (United States)

    Gordon, Assaf T; Land, Rebekah M

    2009-01-01

    This report describes the unusual case of an everyday-use prosthesis suspension system failure during the freefall phase of a skydiving jump. The case individual was a 53-year-old male with a left transtibial amputation secondary to trauma. He used his everyday prosthesis, a transtibial endoskeleton with push-button, plunger-releasing, pin-locking silicon liner suction suspension and a neoprene knee suspension sleeve, for a standard recreational tandem skydive. Within seconds of exiting the plane, the suspension systems failed, resulting in the complete prosthesis floating away. Several factors may have led to suspension system failure, including an inadequate seal and material design of the knee suspension sleeve and liner, lack of auxiliary suspension mechanisms, and lack of a safety cover overlying the push-button release mechanism. This is the first report, to our knowledge, to discuss prosthetic issues specifically related to skydiving. While amputees are to be encouraged to participate in this extreme sport, special modifications to everyday components may be necessary to reduce the possibility of prosthesis failure during freefall, parachute deployment, and landing.

  4. Development of an underactuated hand prosthesis with compliant control

    NARCIS (Netherlands)

    Peerdeman, Bart

    2014-01-01

    The main subjects of this thesis are the mechanical design and control of a new hand prosthesis prototype: the UT Hand I. The functionality of modern hand prostheses is mainly limited by the size and weight of their actuators. The UT Hand I features a minimal actuation system, where all finger joint

  5. Fitting a temporomandibular joint prosthesis to the skull

    NARCIS (Netherlands)

    van Loon, JP; de Bont, LGM; Stegenga, B; Verkerke, GJ

    2000-01-01

    Fitting a temporomandibular joint (TMJ) prosthesis to the skull by using stock prostheses seems to be an appropriate method. However, fitting the skull with one stock part requires many differently shaped parts. Therefore, we fitted the skull with two connected stock parts. The aim of the study was

  6. Groningen temporomandibular joint prosthesis. Development and first clinical application

    NARCIS (Netherlands)

    van Loon, JP; de Bont, LGM; Stegenga, B; Spijkervet, FKL; Verkerke, GJ

    2002-01-01

    Patients with a severely degenerated temporomandibular joint (TMJ) may benefit from an alloplastic TMJ replacement. The aim of the study was to develop a safe and properly functioning TMJ prosthesis. The design was based on imitation of anterior condylar translation by an inferiorly located centre o

  7. Biomechanical conceptual design of a passive transfemoral prosthesis

    NARCIS (Netherlands)

    Ünal, R.; Carloni, R.; Hekman, E.E.G.; Stramigioli, S.; Koopman, H.F.J.M.

    2010-01-01

    In this study, we present the conceptual design of a fully-passive transfemoral prosthesis. The proposed design is inspired by the analysis of the musculo-skeletal activity of the healthy human leg. In order to realize an energy efficient device, we introduce three storage elements, which are respon

  8. 21 CFR 872.3970 - Interarticular disc prosthesis (interpositional implant).

    Science.gov (United States)

    2010-04-01

    ... implant). 872.3970 Section 872.3970 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3970 Interarticular disc prosthesis (interpositional implant). (a) Identification. An interarticular disc...

  9. 21 CFR 874.3730 - Laryngeal prosthesis (Taub design).

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Laryngeal prosthesis (Taub design). 874.3730 Section 874.3730 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... pulmonary air flow to the pharynx in the absence of the larynx, thereby permitting esophageal speech....

  10. Cosmetic effect of knee joint in a knee disarticulation prosthesis

    NARCIS (Netherlands)

    de laat, Fred A.; van der Pluijm, Mark J.; van Kuijk, Annette A.; Geertzen, Jan H.; Roorda, Leo D.

    2014-01-01

    Despite numerous advantages, knee disarticulations (KDs) are rarely performed because of the anticipated KD prosthesis fitting problems that include the positioning of the knee joint distally from the KD socket. This results in lengthening of the thigh and subsequent shortening of the shank. The obj

  11. AUTOLOGOUS VEIN SUPPORTED WITH A BIODEGRADABLE PROSTHESIS FOR ARTERIAL GRAFTING

    NARCIS (Netherlands)

    ZWEEP, HP; SATOH, S; VANDERLEI, B; HINRICHS, WLJ; DIJK, F; FEIJEN, J; WILDEVUUR, CRH

    1993-01-01

    To evaluate the potential of a supporting, compliant, biodegradable prosthesis to function as a temporary protective scaffold for autologous vein grafts in the arterial circulation, we implanted vein grafts into the carotid arteries of rabbits, either with (composite grafts) or without (control graf

  12. Palatal lifting prosthesis and velopharyngeal insufficiency: Preliminary report

    Directory of Open Access Journals (Sweden)

    Ali Ibrahim Aboloyoun

    2013-05-01

    Full Text Available Objectives. Our study aimed to highlight the effectiveness of palatal lift prosthesis in patients with velopharyngeal insufficiency with previous operated cleft palate. Methods. This study was done undertaken January 2008 to December of 2009 in the Phoniatic unit of Alnoor Specialist Hospital, Makkah, Saudi Arabia. Ten patients of ≥ 8 years to ≤ 10 years of age, who had previously undergone surgery for cleft palate, with or without cleft lip, with no other systemic illness and normal intelligent quotient level, were selected and managed by palatal lift prosthesis. All the study subjects were subjected to auditory perceptual speech evaluation for assessment of the degree of hypernasality, compensatory articulator mechanisms, glottal and pharyngeal articulation, audible nasal emission, facial grimace and overall intelligibility of speech. Data were analyzed using SPSS version 16. Results. The study included 10 subjects whose mean ± standard deviation of age was (8.9±0.9. On auditory speech perceptual evaluation after prosthesis application, significant improvement was found in glottal articulation 6 (85.7%, p=0.04, facial grimace 6 (85.7% p=0.04, hyper nasality 10 (10% p=0.008, and speech intelligibility 9 (90% p=0.008. Conclusion. Young patients with repaired palatal cleft have significant improvement after application of palatal lift prosthesis.

  13. 48 CFR 204.7204 - Maintenance of the CAGE file.

    Science.gov (United States)

    2010-10-01

    ...) Submit requests for changes to CAGE files on DD Form 2051, or electronic equivalent, to—Defense Logistics.... Telephone Numbers: toll-free (888) 352-9333, DSN 932-4725, commercial (616) 961-4725. Facsimile: (616) 961... contracting and contract administration office receiving notification of changes from the commercial...

  14. Assessment of the Usability of the Workbench Faraday Cage Method

    DEFF Research Database (Denmark)

    Sørensen, Morten; Franek, Ondrej; Christensen, Søren K.

    2011-01-01

    The workbench Faraday Cage method (WBFC) is a time efficient module pre-compliance test regarding radiated emission. This work investigates the method’s usability and credibility and concludes that for this particular case the WBFC perform a tolerable compliance test for frequencies below 360 MHz...

  15. Environmental Impact of Cage Culture on Poondi Reservoir, Tamil Nadu

    Directory of Open Access Journals (Sweden)

    P. Anusuya Devi

    2015-12-01

    Full Text Available The present investigation was carried out in Poondi reservoir, Tamil Nadu, for a period of 8 months from September, 2014 to April, 2015 where the cage culture has been already initiated by the state fisheries department. The water and sediment samples were collected from the reservoir at point and non- point sources of the cage culture units and were analyzed for their physico-chemical parameters. The total microbial load, E. coli and feacal streptococci population were also assessed from the reservoir. During the study period, pH, sulphate, nitrate and BOD values were found within the permissible range for drinking water quality. The alkalinity values were found optimum in the reservoir water. The sediment characteristics such as pH, electrical conductivity, total organic carbon and available phosphorus values were also found to be within the standard limit. The optimum water and sediment quality characteristics and the absence of E. coli and feacal streptococci observed in the cage culture unit clearly showed that the small cage farming in the reservoir does not have major environmental impacts on the water and sediment quality.

  16. EFFECTS OF CAGING DENSITY ON PITUITARY AND TESTICLE RELATED RESPONSES

    Science.gov (United States)

    Effects of caging density on pituitary and testicle related responses A significant negative correlation between the incidence of testicular interstitial cell tumors (ICT) and of pituitary tumors (PT) in control male F344 rats is reported associated with the number of ani...

  17. Massive acetabular bone loss: Limits of trabecular metal cages

    Directory of Open Access Journals (Sweden)

    Villanueva-Martínez Manuel

    2011-01-01

    Full Text Available Massive acetabular bone loss (more than 50% of the acetabular area can result in insufficient native bone for stable fixation and long-term bone ingrowth of conventional porous cups. The development of trabecular metal cages with osteoconductive properties may allow a more biological and versatile approach that will help restore bone loss, thus reducing the frequency of implant failure in the short-to-medium term. We report a case of massive bone loss affecting the dome of the acetabulum and the ilium, which was treated with a trabecular metal cage and particulate allograft. Although the trabecular metal components had no intrinsic stability, they did enhance osseointegration and incorporation of a non-impacted particulate graft, thus preventing failure of the reconstruction. The minimum 50% contact area between the native bone and the cup required for osseointegration with the use of porous cups may not hold for new trabecular metal cups, thus reducing the need for antiprotrusio cages. The osteoconductive properties of trabecular metal enhanced allograft incorportation and iliac bone rebuilding without the need to fill the defect with multiple wedges nor protect the reconstruction with an antiprotrusio cage.

  18. Dynamics of caged ions in glassy ionic conductors.

    Science.gov (United States)

    Habasaki, J; Ngai, K L; Hiwatari, Y

    2004-05-01

    At sufficiently high frequency and low temperature, the dielectric responses of glassy, crystalline, and molten ionic conductors all invariably exhibit nearly constant loss. This ubiquitous characteristic occurs in the short-time regime when the ions are still caged, indicating that it could be a determining factor of the mobility of the ions in conduction at longer times. An improved understanding of its origin should benefit the research of ion conducting materials for portable energy source as well as the resolution of the fundamental problem of the dynamics of ions. We perform molecular dynamics simulations of glassy lithium metasilicate (Li2SiO3) and find that the length scales of the caged Li+ ions motions are distributed according to a Levy distribution that has a long tail. These results suggest that the nearly constant loss originates from "dynamic anharmonicity" experienced by the moving but caged Li+ ions and provided by the surrounding matrix atoms executing correlated movements. The results pave the way for rigorous treatments of caged ion dynamics by nonlinear Hamiltonian dynamics.

  19. Multiexpandable cage for minimally invasive posterior lumbar interbody fusion

    Directory of Open Access Journals (Sweden)

    Coe JD

    2016-09-01

    Full Text Available Jeffrey D Coe,1 James F Zucherman,2 Donald W Kucharzyk,3 Kornelis A Poelstra,4 Larry E Miller,5 Sandeep Kunwar,6 1Silicon Valley Spine Institute, Campbell, 2San Francisco Orthopaedic Surgeons, San Francisco, CA, 3Orthopaedic Pediatric and Spine, Crown Point, IN, 4Department of Surgery, Sacred Heart Hospital on the Emerald Coast, Miramar Beach, FL, 5Miller Scientific Consulting, Inc., Asheville, NC, 6Bell Neuroscience Institute, Washington Hospital Healthcare System, Fremont, CA, USA Abstract: The increasing adoption of minimally invasive techniques for spine surgery in recent years has led to significant advancements in instrumentation for lumbar interbody fusion. Percutaneous pedicle screw fixation is now a mature technology, but the role of expandable cages is still evolving. The capability to deliver a multiexpandable interbody cage with a large footprint through a narrow surgical cannula represents a significant advancement in spinal surgery technology. The purpose of this report is to describe a multiexpandable lumbar interbody fusion cage, including implant characteristics, intended use, surgical technique, preclinical testing, and early clinical experience. Results to date suggest that the multiexpandable cage allows a less invasive approach to posterior/transforaminal lumbar interbody fusion surgery by minimizing iatrogenic risks associated with static or vertically expanding interbody prostheses while providing immediate vertebral height restoration, restoration of anatomic alignment, and excellent early-term clinical results. Keywords: degenerative disc disease, expandable, low back pain, Luna

  20. Three-dimensional protonic conductivity in porous organic cage solids

    Science.gov (United States)

    Liu, Ming; Chen, Linjiang; Lewis, Scott; Chong, Samantha Y.; Little, Marc A.; Hasell, Tom; Aldous, Iain M.; Brown, Craig M.; Smith, Martin W.; Morrison, Carole A.; Hardwick, Laurence J.; Cooper, Andrew I.

    2016-09-01

    Proton conduction is a fundamental process in biology and in devices such as proton exchange membrane fuel cells. To maximize proton conduction, three-dimensional conduction pathways are preferred over one-dimensional pathways, which prevent conduction in two dimensions. Many crystalline porous solids to date show one-dimensional proton conduction. Here we report porous molecular cages with proton conductivities (up to 10-3 S cm-1 at high relative humidity) that compete with extended metal-organic frameworks. The structure of the organic cage imposes a conduction pathway that is necessarily three-dimensional. The cage molecules also promote proton transfer by confining the water molecules while being sufficiently flexible to allow hydrogen bond reorganization. The proton conduction is explained at the molecular level through a combination of proton conductivity measurements, crystallography, molecular simulations and quasi-elastic neutron scattering. These results provide a starting point for high-temperature, anhydrous proton conductors through inclusion of guests other than water in the cage pores.

  1. Business plan Tilapia cage farming in Tete Zambezi Valley, Mozambique

    NARCIS (Netherlands)

    Meer, van der Magnus; Brouwer, Herman

    2015-01-01

    Tete province offers great opportunities for cage farming of tilapia in Lake Cahora Bassa. The climate and water quality are favourable for fish production, and the fast economic developments in the region will facilitate fish sales. In Tete tilapia (pende) is highly valued food. Major markets for t

  2. Sex effect in mutual olfactory relationships of individually caged rabbits

    Directory of Open Access Journals (Sweden)

    Alessandro Finzi

    2015-12-01

    Full Text Available To assess the sex influence on sniffing behavior of rabbits, sets of three rabbits each were located for seven days in contiguous cages divided by a metal wall with holes that prevented the neighboring rabbits to see each other. A buck was located in the central cage, with a doe at each side. Rabbit behavior was video recorded to observe animals sniffing with the muzzle near the wall. The bucks displayed an olfactory preference towards one of the two does, which decreased in few days. The significance was p  0.05. The interest of bucks towards the does was also characterized by a frenetic scratching of the separation wall, contemporary with intense sniffing, displayed only for the first 35 min of the first day. The sniffing behavior of does at the central cage housing the male was not so marked as in bucks, and it progressively changed across the trial (p < 0.01. In conclusion, rabbits establish a transitory sex-oriented olfactory relationship with the conspecifics housed in contiguous cages, which looks no longer necessary once the rabbits have recognized each other.

  3. Three-dimensional protonic conductivity in porous organic cage solids

    Science.gov (United States)

    Liu, Ming; Chen, Linjiang; Lewis, Scott; Chong, Samantha Y.; Little, Marc A.; Hasell, Tom; Aldous, Iain M.; Brown, Craig M.; Smith, Martin W.; Morrison, Carole A.; Hardwick, Laurence J.; Cooper, Andrew I.

    2016-01-01

    Proton conduction is a fundamental process in biology and in devices such as proton exchange membrane fuel cells. To maximize proton conduction, three-dimensional conduction pathways are preferred over one-dimensional pathways, which prevent conduction in two dimensions. Many crystalline porous solids to date show one-dimensional proton conduction. Here we report porous molecular cages with proton conductivities (up to 10−3 S cm−1 at high relative humidity) that compete with extended metal-organic frameworks. The structure of the organic cage imposes a conduction pathway that is necessarily three-dimensional. The cage molecules also promote proton transfer by confining the water molecules while being sufficiently flexible to allow hydrogen bond reorganization. The proton conduction is explained at the molecular level through a combination of proton conductivity measurements, crystallography, molecular simulations and quasi-elastic neutron scattering. These results provide a starting point for high-temperature, anhydrous proton conductors through inclusion of guests other than water in the cage pores. PMID:27619230

  4. The biological effect of cage design corrected for reductions in spray penetration

    OpenAIRE

    Fritz Bradley Keith; Hoffmann Wesley Clint; Bonds Jane Annalise Sara; Haas Keith; Czaczyk Zbigniew

    2014-01-01

    In-field measures of physical spray concentration do not tend to correlate well with caged insect mortality data. This is partly due to the reduced penetration of the spray into the cage. Spray penetration is hindered by the structure of the cage. Wind tunnel studies were conducted to investigate the accuracy of those calculations developed to correct for filtration levels in caged mosquito bioassays. Zenivex E20 (Etofenprox) was applied at rates ranging from an LD10 to an LD90. Thre...

  5. Mouse Housing System Using Pressurized Cages Intraventilated by Direct-Current Microfans

    OpenAIRE

    Martinewski, Alexandre; Correia, Caio SC; de Souza, Nívea L; Merusse, José LB

    2012-01-01

    We performed the initial assessment of an alternative pressurized intraventilated (PIV) caging system for laboratory mice that uses direct-current microfans to achieve cage pressurization and ventilation. Twenty-nine pairs of female SPF BALB/c mice were used, with 19 experimental pairs kept in PIV cages and 10 control pairs kept in regular filter-top (FT) cages. Both groups were housed in a standard housing room with a conventional atmospheric control system. For both systems, intracage tempe...

  6. Laser Induced C60 Cage Opening Studied by Semiclassical Dynamics Simulation

    Directory of Open Access Journals (Sweden)

    Yusheng Dou

    2011-01-01

    Full Text Available Laser induced opening of the C60 cage is studied by a semiclassical electron-radiation-ion dynamics technique. The simulation results indicate that the C60 cage is abruptly opened immediately after laser excitation. The opening of the C60 cage induces a quick increase in kinetic energy and a sharp decrease in electronic energy, suggesting that the breaking of the C60 cage efficiently heats up the cluster and enhances the thermal fragmentation of C60 fullerene.

  7. Social communication in mice--are there optimal cage conditions?

    Directory of Open Access Journals (Sweden)

    Allain-Thibeault Ferhat

    Full Text Available Social communication is heavily affected in patients with neuropsychiatric disorders. Accordingly, mouse models designed to study the mechanisms leading to these disorders are tested for this phenotypic trait. Test conditions vary between different models, and the effect of these test conditions on the quantity and quality of social interactions and ultrasonic communication is unknown. The present study examines to which extent the habituation time to the test cage as well as the shape/size of the cage influence social communication in freely interacting mice. We tested 8 pairs of male mice in free dyadic social interactions, with two habituation times (20 min and 30 min and three cage formats (rectangle, round, square. We tested the effect of these conditions on the different types of social contacts, approach-escape sequences, follow behavior, and the time each animal spent in the vision field of the other one, as well as on the emission of ultrasonic vocalizations and their contexts of emission. We provide for the first time an integrated analysis of the social interaction behavior and ultrasonic vocalizations. Surprisingly, we did not highlight any significant effect of habituation time and cage shape/size on the behavioral events examined. There was only a slight increase of social interactions with the longer habituation time in the round cage. Remarkably, we also showed that vocalizations were emitted during specific behavioral sequences especially during close contact or approach behaviors. The present study provides a protocol reliably eliciting social contacts and ultrasonic vocalizations in adult male mice. This protocol is therefore well adapted for standardized investigation of social interactions in mouse models of neuropsychiatric disorders.

  8. Cage Versus Noncage Laying-Hen Housings: Worker Respiratory Health.

    Science.gov (United States)

    Mitchell, Diane; Arteaga, Veronica; Armitage, Tracey; Mitloehner, Frank; Tancredi, Daniel; Kenyon, Nicholas; Schenker, Marc

    2015-01-01

    The objective of this study was to compare respiratory health of poultry workers in conventional cage, enriched cage and aviary layer housing on a single commercial facility, motivated by changing requirements for humane housing of hens. Three workers were randomly assigned daily, one to each of conventional cage, enriched cage, and aviary housing in a crossover repeated-measures design for three observation periods (for a total of 123 worker-days, eight different workers). Workers' exposure to particles were assessed (Arteaga et al. J Agromedicine. 2015;20:this issue) and spirometry, exhaled nitric oxide, respiratory symptoms, and questionnaires were conducted pre- and post-shift. Personal exposures to particles and endotoxin were significantly higher in the aviary than the other housings (Arteaga et al., 2015). The use of respiratory protection was high; the median usage was 70% of the shift. Mixed-effects multivariate regression models of respiratory cross-shift changes were marginally significant, but the aviary system consistently posted the highest decrements for forced expiratory volume in 1 and 6 seconds (FEV1 and FEV6) compared with the enriched or conventional housing. The adjusted mean difference in FEV1 aviary - enriched cage housing was -47 mL/s, 95% confidence interval (CI): (-99 to 4.9), P = .07. Similarly, for FEV6, aviary - conventional housing adjusted mean difference was -52.9 mL/6 s, 95% CI: (-108 to 2.4), P = .06. Workers adopting greater than median use of respiratory protection were less likely to exhibit negative cross-shift pulmonary function changes. Although aviary housing exposed workers to significantly higher respiratory exposures, cross-shift pulmonary function changes did not differ significantly between houses. Higher levels of mask use were protective; poultry workers should wear respiratory protection as appropriate to avoid health decrements.

  9. Development of an internally braced prosthesis for total talus replacement.

    Science.gov (United States)

    Regauer, Markus; Lange, Mirjam; Soldan, Kevin; Peyerl, Steffen; Baumbach, Sebastian; Böcker, Wolfgang; Polzer, Hans

    2017-03-18

    Total loss of talus due to trauma or avascular necrosis, for example, still remains to be a major challenge in foot and ankle surgery with severely limited treatment options. Implantation of a custom made total talar prosthesis has shown promising results so far. Most important factors for long time success are degree of congruence of articular surfaces and ligamentous stability of the ankle. Therefore, our aim was to develop an optimized custom made prosthesis for total talus replacement providing a high level of primary stability. A custom made hemiprosthesis was developed using computed tomography and magnetic resonance imaging data of the affected and contralateral talus considering the principles and technology for the development of the S.T.A.R. prosthesis (Stryker). Additionally, four eyelets for fixation of artificial ligaments were added at the correspondent footprints of the most important ligaments. Two modifications can be provided according to the clinical requirements: A tri-articular hemiprosthesis or a bi-articular hemiprosthesis combined with the tibial component of the S.T.A.R. total ankle replacement system. A feasibility study was performed using a fresh frozen human cadaver. Maximum range of motion of the ankle was measured and ligamentous stability was evaluated by use of standard X-rays after application of varus, valgus or sagittal stress with 150 N. Correct implantation of the prosthesis was technically possible via an anterior approach to the ankle and using standard instruments. Malleolar osteotomies were not required. Maximum ankle dorsiflexion and plantarflexion were measured as 22-0-28 degrees. Maximum anterior displacement of the talus was 6 mm, maximum varus tilt 3 degrees and maximum valgus tilt 2 degrees. Application of an internally braced prosthesis for total talus replacement in humans is technically feasible and might be a reasonable procedure in carefully selected cases with no better alternatives left.

  10. Prosthesis for open pleurostomy (POP: management for chronic empyemas

    Directory of Open Access Journals (Sweden)

    Luiz Tarcísio Brito Filomeno

    2009-03-01

    Full Text Available OBJECTIVES: We developed a prosthesis for open pleurostomy cases where pulmonary decortication is not indicated, or where post-pneumonectomy space infection occurs. The open pleural window procedure not only creates a large hole in the chest wall that is shocking to patients, also results in a permanent deformation of the thorax. prosthesis for open pleurostomy is a self-retained silicone tube that requires the removal of 3 cm of one rib for insertion, and acts as a mature conventional open pleural window. Herein, we report our 13-year experience with this device in the management of different kinds of pleural empyema. METHODS: Forty-four consecutive patients with chronic empyema were treated. The etiology of empyema was diverse: pneumonia, 20; lung resections, 12 (pneumonectomies, 7; lobectomies, 4; non-anatomical, 1; mixed-tuberculous, 6; and mixed-malignant pleural effusion, 6. After debridment of both pleural surfaces, the prosthesis for open pleurostomy was inserted and attached to a small recipient plastic bag. RESULTS: Infection control was achieved in 20/20 (100% of the parapneumonic empyemas, in 3/4 (75% of post-lobectomies, in 6/7 (85% of post-pneumectomies, in 6/6 (100% of mixed-tuberculous cases, and in 4/6 (83% of mixed-malignant cases. Lung re-expansion was also successful in 93%, 75%, 33%, and 40% of the groups, respectively CONCLUSIONS: Prosthesis for open pleurostomy insertion is a minimally invasive procedure that can be as effective as conventional open pleural window for management of chronic empyemas. Thus, we propose that the use of prosthesis for open pleurostomy should replace the conventional method.

  11. The effects of climbing cages on behaviour of female mink during the lactation period

    DEFF Research Database (Denmark)

    Lidfors, L.; Axelsson, H.; Loberg, J.;

    2012-01-01

    The aim was to investigate if there were differences in behaviour of female mink when kept in a climbing cage compared with a standard cage during the lactation period. The study was carried out on 90 mink of the colour type "black cross". Females were housed in either climbing cages (4.350 cm², n...

  12. 48 CFR 252.204-7001 - Commercial and Government Entity (CAGE) code reporting.

    Science.gov (United States)

    2010-10-01

    ... Entity (CAGE) code reporting. 252.204-7001 Section 252.204-7001 Federal Acquisition Regulations System... Entity (CAGE) Code Reporting (AUG 1999) (a) The offeror is requested to enter its CAGE code on its offer... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.204-7001 Commercial and Government...

  13. [The endo-exo prosthesis for patients with a problematic amputation stump].

    Science.gov (United States)

    Frölke, Jan Paul M; van de Meent, Henk

    2010-01-01

    Following lower limb amputation, quality of life is highly related to the ability to use a prosthetic limb. The conventional way to attach a prosthetic limb to the body is with a socket. Many patients experience serious discomfort wearing a conventional prosthesis because of pain, instability during walking, pressure sores, bad smell or skin irritation. In addition, sitting is uncomfortable and pelvic and lower back pain due to unstable gait is often seen in these patients. The main disadvantage of the current prosthesis is the attachment of a rigid prosthesis socket to a soft and variable body. The socket must fit tightly for stability during walking but should also be comfortable for sitting. The implantation of an osseointegrated, intramedullary, transcutaneously conducted prosthesis is a new procedure for attaching a limb prosthesis to the human body without the disadvantages of the conventional prosthesis. The intramedullary prosthesis is designed with a rough surface resembling cancellous bone to enable a secure solid integration with the long bone. We treated two patients with this new prosthesis, a 44-year-old man after a transfemoral amputation, and a 32-year-old woman after a lower leg amputation; both amputations were necessary because of trauma. Those two patients are now, more than one year after the operation, showing excellent functional results without infectious complications. We assume that endo-exo prosthesis may be a promising option for selected patients unable to use a conventional prosthesis because of a problematic amputation stump.

  14. Powered ankle-foot prosthesis for the improvement of amputee ambulation.

    Science.gov (United States)

    Au, Samuel K; Herr, Hugh; Weber, Jeff; Martinez-Villalpando, Ernesto C

    2007-01-01

    This paper presents the mechanical design, control scheme, and clinical evaluation of a novel, motorized ankle-foot prosthesis, called MIT Powered Ankle-Foot Prosthesis. Unlike a conventional passive-elastic ankle-foot prosthesis, this prosthesis can provide active mechanical power during the stance period of walking. The basic architecture of the prosthesis is a unidirectional spring, configured in parallel with a force-controllable actuator with series elasticity. With this architecture, the anklefoot prosthesis matches the size and weight of the human ankle, and is also capable of delivering high mechanical power and torque observed in normal human walking. We also propose a biomimetic control scheme that allows the prosthesis to mimic the normal human ankle behavior during walking. To evaluate the performance of the prosthesis, we measured the rate of oxygen consumption of three unilateral transtibial amputees walking at self-selected speeds to estimate the metabolic walking economy. We find that the powered prosthesis improves amputee metabolic economy from 7% to 20% compared to the conventional passive-elastic prostheses (Flex-Foot Ceterus and Freedom Innovations Sierra), even though the powered system is twofold heavier than the conventional devices. This result highlights the benefit of performing net positive work at the ankle joint to amputee ambulation and also suggests a new direction for further advancement of an ankle-foot prosthesis.

  15. Rotational Brownian Dynamics simulations of clathrin cage formation

    Energy Technology Data Exchange (ETDEWEB)

    Ilie, Ioana M.; Briels, Wim J. [Computational BioPhysics, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede (Netherlands); MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede (Netherlands); Otter, Wouter K. den, E-mail: w.k.denotter@utwente.nl [Computational BioPhysics, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede (Netherlands); MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede (Netherlands); Multi Scale Mechanics, Faculty of Engineering Technology, University of Twente, P.O. Box 217, 7500 AE Enschede (Netherlands)

    2014-08-14

    The self-assembly of nearly rigid proteins into ordered aggregates is well suited for modeling by the patchy particle approach. Patchy particles are traditionally simulated using Monte Carlo methods, to study the phase diagram, while Brownian Dynamics simulations would reveal insights into the assembly dynamics. However, Brownian Dynamics of rotating anisotropic particles gives rise to a number of complications not encountered in translational Brownian Dynamics. We thoroughly test the Rotational Brownian Dynamics scheme proposed by Naess and Elsgaeter [Macromol. Theory Simul. 13, 419 (2004); Naess and Elsgaeter Macromol. Theory Simul. 14, 300 (2005)], confirming its validity. We then apply the algorithm to simulate a patchy particle model of clathrin, a three-legged protein involved in vesicle production from lipid membranes during endocytosis. Using this algorithm we recover time scales for cage assembly comparable to those from experiments. We also briefly discuss the undulatory dynamics of the polyhedral cage.

  16. Mutual Inductance in the Bird-Cage Resonator

    Science.gov (United States)

    Tropp, James

    1997-05-01

    Formulas are derived to account for the effect of the mutual inductances, between all meshes, upon the electrical resonance spectra bird-cage resonators, and similar structures such as the TEM resonator of P. K. H. Röschmann (United States Patent 4,746,866) and J. T. Vaughanet al.(Magn. Reson. Med.32,206, 1994). The equations are parameterized in terms of isolated mesh frequencies and coupling coefficients, and ought therefore apply not only to simple magnetic couplings used in the derivation, but to electromagnetic couplings as well. A method for measuring the coupling coefficients-applicable to shielded as well as unshielded resonators-is described, based upon the splitting of frequencies in pairs of coupled resonators; and detailed comparisons are given between calculated and measured resonance spectra: for bird-cage resonators, with and without shields, and for the TEM resonator.

  17. Macromolecularly "Caged" Carbon Nanoparticles for Intracellular Trafficking via Switchable Photoluminescence.

    Science.gov (United States)

    Misra, Santosh K; Srivastava, Indrajit; Tripathi, Indu; Daza, Enrique; Ostadhossein, Fatemeh; Pan, Dipanjan

    2017-02-08

    Reversible switching of photoluminescence (PL) of carbon nanoparticles (CNP) can be achieved with counterionic macromolecular caging and decaging at the nanoscale. A negatively charged uncoated, "bare" CNP with high luminescence loses its PL when positively charged macromolecules are wrapped around its surface. Prepared caged carbons could regain their emission only through interaction with anionic surfactant molecules, representing anionic amphiphiles of endocytic membranes. This process could be verified by gel electrophoresis, spectroscopically and in vitro confocal imaging studies. Results indicated for the first time that luminescence switchable CNPs can be synthesized for efficient intracellular tracking. This study further supports the origin of photoluminescence in CNP as a surface phenomenon correlated a function of characteristic charged macromolecules.

  18. Lanthanides caged by the organic chelates; structural properties.

    Science.gov (United States)

    Smentek, Lidia

    2011-04-13

    The structure, in particular symmetry, geometry and morphology of organic chelates coordinated with the lanthanide ions are analyzed in the present review. This is the first part of a complete presentation of a theoretical description of the properties of systems, which are widely used in technology, but most of all, in molecular biology and medicine. The discussion is focused on the symmetry and geometry of the cages, since these features play a dominant role in the spectroscopic activity of the lanthanides caged by organic chelates. At the same time, the spectroscopic properties require more formal presentation in the language of Racah algebra, and deserve a separate analysis. In addition to the parent systems of DOTA, DOTP, EDTMP and CDTMP presented here, their modifications by various antennas are analyzed. The conclusions that have a strong impact upon the theory of the energy transfer and the sensitized luminescence of these systems are based on the results of numerical density functional theory calculations.

  19. Rotational Brownian dynamics simulations of clathrin cage formation.

    Science.gov (United States)

    Ilie, Ioana M; den Otter, Wouter K; Briels, Wim J

    2014-08-14

    The self-assembly of nearly rigid proteins into ordered aggregates is well suited for modeling by the patchy particle approach. Patchy particles are traditionally simulated using Monte Carlo methods, to study the phase diagram, while Brownian Dynamics simulations would reveal insights into the assembly dynamics. However, Brownian Dynamics of rotating anisotropic particles gives rise to a number of complications not encountered in translational Brownian Dynamics. We thoroughly test the Rotational Brownian Dynamics scheme proposed by Naess and Elsgaeter [Macromol. Theory Simul. 13, 419 (2004); Naess and Elsgaeter Macromol. Theory Simul. 14, 300 (2005)], confirming its validity. We then apply the algorithm to simulate a patchy particle model of clathrin, a three-legged protein involved in vesicle production from lipid membranes during endocytosis. Using this algorithm we recover time scales for cage assembly comparable to those from experiments. We also briefly discuss the undulatory dynamics of the polyhedral cage.

  20. Mutual Inductance in the Bird-Cage Resonator

    Science.gov (United States)

    Tropp

    1997-05-01

    Formulas are derived to account for the effect of the mutual inductances, between all meshes, upon the electrical resonance spectra bird-cage resonators, and similar structures such as the TEM resonator of P. K. H. Roschmann (United States Patent 4,746,866) and J. T. Vaughan et al. (Magn. Reson. Med. 32, 206, 1994). The equations are parameterized in terms of isolated mesh frequencies and coupling coefficients, and ought therefore apply not only to simple magnetic couplings used in the derivation, but to electromagnetic couplings as well. A method for measuring the coupling coefficients-applicable to shielded as well as unshielded resonators-is described, based upon the splitting of frequencies in pairs of coupled resonators; and detailed comparisons are given between calculated and measured resonance spectra: for bird-cage resonators, with and without shields, and for the TEM resonator.

  1. Influence of Manufacturing Process of Warp-knitted Vascular Prosthesis on the Wall Homogeneity

    Institute of Scientific and Technical Information of China (English)

    王璐; 丁辛

    2003-01-01

    This paper reports the evolution of textile structure and mechanical properties of vascular prosthesis in the level of the whole prosthesis and the constituent filaments with respect to the manufacturing process.The tubular wall of the prosthesis is divided circumferentially into three zones: basic line (BL),remeshing line (RL) and guide line (GL). Some heterogeneity has been observed on the tubular wall in :erms of stitch structure of the prosthesis and linear density of the constituent filaments. The breaking position of the prosthesis under circumferential tensile localizes preferentially in remeshing line that is the weakest zone by warp knitting with double needle bed. Furthermore, the statistical differences of the mechanical properties of the filaments of zone RL, GL and BL have been confirmed too. It is predictable that the deterioration of prosthesis, under physiological loads (periodical pulse blood pressure etc.), could happen firstly in the weaker zone in vivo.

  2. Manufacturer-provided effective orifice area index charts and the prevention of prosthesis-patient mismatch.

    Science.gov (United States)

    House, Chad M; Nelson, William B; Kroshus, Timothy J; Dahiya, Ranjan; Pibarot, Philippe

    2012-01-01

    Prosthesis-patient mismatch (PPM) occurs when an implanted prosthesis is too small relative to the patient's body surface area (BSA). However, mismatch can often be prevented by indexing the expected effective orifice area (EOA) of a prosthesis to the patient's BSA and then selecting the largest implantable prosthesis to avoid mismatch. Previously, prosthesis manufacturers have attempted to simplify this process by providing charts that include the expected EOA for their prosthesis, already indexed into an array of BSA values. One caveat with these charts is that the expected EOA data must truly be reliable, or the charts will misguide the implanting surgeon. Manufacturer-provided charts could be improved by standardizing the EOA data, with one potential source being the hemodynamic data submitted to the United States Food and Drug Administration. This review discusses PPM, manufacturer-provided EOA charts, and the regulation of EOA data.

  3. Early access to perches in caged White Leghorn pullets.

    Science.gov (United States)

    Enneking, S A; Cheng, H W; Jefferson-Moore, K Y; Einstein, M E; Rubin, D A; Hester, P Y

    2012-09-01

    Osteoporosis, a progressive decrease in mineralized structural bone, causes 20 to 35% of all mortalities in caged White Leghorn hens. Previous research has focused on manipulating the egg laying environment to improve skeletal health, with little research on the pullet. The objective of the current study was to determine the effect of perch access on pullet health, bone mineralization, muscle deposition, and stress in caged White Leghorns. From 0 to 17 wk of age, half of the birds were placed in cages with 2 round metal perches, while the other half did not have perches (controls). Bone mineralization and bone size traits were determined in the tibia, femur, sternum, humerus, ulna, radius, and phalange (III carpometacarpal) using dual energy x-ray absorptiometry. Muscle weights were obtained for the breast and left leg (drum and thigh). A sample of pullets from each cage was evaluated for foot health, BW, right adrenal weight, and packed cell volume. Most measurements were taken at 3, 6, and 12 wk of age. Access to perches did not affect breast muscle weight, percentage breast muscle, percentage leg muscle, bone mineral density, bone length, bone width, adrenal weight, packed cell volume, and hyperkeratosis of the foot-pad and toes. There were no differences in BW, bone mineral content, and leg muscle weight at 3 and 6 wk of age. However, at 12 wk of age, BW (P = 0.025), bone mineral content of the tibia, sternum, and humerus (P = 0.015), and the left leg muscle weight (P = 0.006) increased in pullets with access to perches as compared with controls. These results suggest that perch access has beneficial effects on pullet health by stimulating leg muscle deposition and increasing the mineral content of certain bones without causing a concomitant decrease in bone mineral density.

  4. Inherent helicity in an extended tris-bipyridyl molecular cage

    Energy Technology Data Exchange (ETDEWEB)

    Perkins, D.; Lindoy, L.; Meehan, G.; Turner, P. (University of Sydney)

    2010-11-16

    A new molecular cage incorporating three bipyridyl units has been synthesised by a conventional multi-step procedure as well as, much more efficiently, by a Ni(II) template procedure; an X-ray structure of the nickel complex shows that it adopts an exo configuration of each of the bridgehead nitrogen lone pairs, the central metal ion acts to promote a triple helical twist that extends {approx}22 {angstrom} along the axial length of the molecule.

  5. AMS 700 inflatable penile prosthesis with InhibiZone.

    Science.gov (United States)

    McKim, Stephen E; Carson, Culley C

    2010-05-01

    Inflatable penile prostheses are the definitive therapy for erectile dysfunction refractory to medical therapy. For years mechanical malfunction was the most common cause of device failure, but recent advances in design have largely eliminated this, and now infection is the most significant problem with these implants. Antibiotic-coated medical devices, such as central venous and bladder catheters, have proven effective in reducing bacterial colonization and biofilm formation, leading to decreased rates of infection. In 2001, American Medical Systems (AMS) released its AMS 700 series penile prosthesis impregnated with a proprietary combination of the antibiotics rifampin and minocycline, called InhibiZone. Multiple studies have found that this device significantly reduces infection rates in men receiving penile prostheses. In July 2009, the US FDA approved the AMS 700 with InhibiZone as the only inflatable penile prosthesis with clinical evidence showing significant reduction in the rate of revision surgery due to infection.

  6. Running with a powered knee and ankle prosthesis.

    Science.gov (United States)

    Shultz, Amanda H; Lawson, Brian E; Goldfarb, Michael

    2015-05-01

    This paper presents a running control architecture for a powered knee and ankle prosthesis that enables a transfemoral amputee to run with a biomechanically appropriate running gait and to intentionally transition between a walking and running gait. The control architecture consists firstly of a coordination level controller, which provides gait biomechanics representative of healthy running, and secondly of a gait selection controller that enables the user to intentionally transition between a running and walking gait. The running control architecture was implemented on a transfemoral prosthesis with powered knee and ankle joints, and the efficacy of the controller was assessed in a series of running trials with a transfemoral amputee subject. Specifically, treadmill trials were conducted to assess the extent to which the coordination controller provided a biomechanically appropriate running gait. Separate trials were conducted to assess the ability of the user to consistently and reliably transition between walking and running gaits.

  7. A cognitive prosthesis for complex decision-making.

    Science.gov (United States)

    Tremblay, Sébastien; Gagnon, Jean-François; Lafond, Daniel; Hodgetts, Helen M; Doiron, Maxime; Jeuniaux, Patrick P J M H

    2017-01-01

    While simple heuristics can be ecologically rational and effective in naturalistic decision making contexts, complex situations require analytical decision making strategies, hypothesis-testing and learning. Sub-optimal decision strategies - using simplified as opposed to analytic decision rules - have been reported in domains such as healthcare, military operational planning, and government policy making. We investigate the potential of a computational toolkit called "IMAGE" to improve decision-making by developing structural knowledge and increasing understanding of complex situations. IMAGE is tested within the context of a complex military convoy management task through (a) interactive simulations, and (b) visualization and knowledge representation capabilities. We assess the usefulness of two versions of IMAGE (desktop and immersive) compared to a baseline. Results suggest that the prosthesis helped analysts in making better decisions, but failed to increase their structural knowledge about the situation once the cognitive prosthesis is removed.

  8. FABRICATION OF CUSTOM OCULAR PROSTHESIS USING A GRAPH GRID.

    Directory of Open Access Journals (Sweden)

    Nidhi Dinesh Sinha

    2009-03-01

    Full Text Available Patients requiring treatment with custom ocular prosthesis are those who have lost ocular structures through orbital evisceration or orbital enucleation which was necessary as a surgical intervention for a congenital defect, pathology or an accident. The disfigurement associated with eye loss can cause significant physical and emotional disturbance. As iris placement is a technique sensitive procedure,visual assessment alone may not be accurate.The present article is an illustration of a case report of a lady chosen for a custom ocular prosthesis. The method described here uses a transparent grid template from which the iris is traced. An attempt is also made to mimick the shade and colour of the sclera in the wax pattern itself; using white paraffin wax. This gives an accurate registration of the position and alignment of iris disc assembly, giving a natural look.

  9. A Blue Tooth – Auricular Prosthesis: A Case Report

    Science.gov (United States)

    H. Naveen, Bandlar; R. Kashinath, Korapathi; B. Shankargouda, Swapnil

    2014-01-01

    The absence of an ear is a considerable aesthetic problem which affects the patient’s psychology and social behaviour. We are describing a case of 25-year-old male reporting to the Department of Prosthodontics, with a chief complaint of deficient left auricular tissue. This can be corrected surgically, prosthetically or through a combination of these approaches; but the choice of treatment depends on patient. The patient chose prosthetic rehabilitation over surgical procedures & retention becomes a critical issue in this approach. Out of many types of retentive methods, we selectively incorporated new materials and used the latest technology to ensure the highest quality prosthesis. Creative approach for each patient with a focus on their individual needs was considered as it gives more satisfaction to the patient. This article describes a new, simple and cost effective technique by embedding Bluetooth-headset device into the silicone elastomer of a mechanically-retained auricular prosthesis. PMID:25302281

  10. Tridimensional Treatment Planning and Rapid Prototyping for Maxillofacial Prosthesis

    Institute of Scientific and Technical Information of China (English)

    ZHANGWen-qiang; YUANJian-bing; YEMing; HUANGXue-mei; WANGCheng-tao

    2004-01-01

    The currert stmulation planing systmes for maxillofacial prosthesis surgery were used to extrapolate 3D surgical movements and outcomes based on the 2D radiographs,which were inadequate for complex surgical movements A 3D treatmenl planning system based on the computerized tomography(CT)data was presented A 3D data field was costructed out of the sectional image stack through linear interpolation after objectire tissue segmentation and using the marching cubes algorithm method,the triangular mesh model and 3D geometric model of diseased facial skeleton were reconstructed then the model was cut,the segments were moved or totated to their predicted positions,and angles and distances were measured after triangular mesh model was decimaled a RP model was manufactured for surgical simulation and prosthesis design The system was used in clinic with more than fifty cases and technically wilidated with success.

  11. Crop impaction resulting from feather ball formation in caged layers.

    Science.gov (United States)

    Morishita, T Y; Aye, P P; Harr, B S

    1999-01-01

    Abnormal behaviors in commercial poultry, including feather pulling and pica, have been known to occur when birds are exposed to an unfamiliar environment. We report here the development of crop impactions resulting from feather ball formation. Twelve specific-pathogen-free (SPF) chickens were placed in one of three cages housed among a commercial layer flock in three different buildings on a farm site. Three weeks after placement, the birds were removed from the cages and given a physical exam. Chickens were thin, and one bird in each of the three caged groups had a palpable mass at the level of the thoracic inlet. At necropsy, a mass was noted in the crop. Upon further dissection, a wet, foul-smelling mass consisting of feathers and feed debris was recovered. Results from our case indicate that unfamiliar surroundings can cause pica in birds. Hence, avian researchers and veterinarians planning to introduce new birds into a flock, i.e., SPF birds, should consider the birds' previous environmental conditions prior to placement because sudden placement in unfamiliar surroundings can result in pica.

  12. The method of manufacture of nylon dental partially removable prosthesis using additive technologies

    Science.gov (United States)

    Kashapov, R. N.; Korobkina, A. I.; Platonov, E. V.; Saleeva, G. T.

    2014-12-01

    The article is devoted to the topic of creating new methods of dental prosthesis. The aim of this work is to investigate the possibility of using additive technology to create nylon prosthesis. As a result of experimental studies, was made a sample of nylon partially removable prosthesis using 3D printing has allowed to simplify, accelerate and reduce the coat of manufacturing high-precision nylon dentures.

  13. Patient satisfaction and penile morphology changes with postoperative penile rehabilitation 2 years after Coloplast Titan prosthesis

    OpenAIRE

    2016-01-01

    A common complaint after inflatable penile prosthesis surgery is reduced penile length. We previously reported how using the Coloplast Titan inflatable penile prosthesis with aggressive new length measurement technique (NLMT) coupled with postoperative IPP rehabilitation of the implant for 1-year helped to improve patient satisfaction and erectile penile measurements. This is a 2 years follow-up of a prospective, three-center, study of 40 patients who underwent Titan prosthesis placement, wit...

  14. Magnetic resonance imaging compatibility test of a cranial prosthesis with titanium screws

    Science.gov (United States)

    Jimenez, R.; Benavides, A.; Flores, D.; Hidalgo, S. S.; Solis, S. E.; Uribe, E.; Rodriguez, A. O.

    2012-10-01

    The follow-up of patients with skull prosthesis is necessary to provide adequate medical care. Skull prostheses for cranioplasty have been developed at the Faculty of Odontology of Universidad Nacional Autonoma de Mexico. We built a skull prosthesis phantom and tested for compatibility with standard magnetic resonance imaging procedures. Results showed full compatibility but susceptibility artefacts occurred due to titanium used to fix the prosthesis to the skull.

  15. Determining skill level in myoelectric prosthesis use with multiple outcome measures

    OpenAIRE

    Hanneke Bouwsema, MSc; Peter J. Kyberd, PhD; Wendy Hill, BScOT; Corry K. van der Sluis, MD, PhD; Raoul M. Bongers, PhD

    2012-01-01

    To obtain more insight into how the skill level of an upper-limb myoelectric prosthesis user is composed, the current study aimed to (1) portray prosthetic handling at different levels of description, (2) relate results of the clinical level to kinematic measures, and (3) identify specific parameters in these measures that characterize the skill level of a prosthesis user. Six experienced transradial myoelectric prosthesis users performed a clinical test (Southampton Hand Assessment Procedure...

  16. Intraoral framework pick-up technique to improve fit of a metal-resin implant prosthesis

    OpenAIRE

    Mirza Rustum Baig; Rajan Gunaseelan

    2012-01-01

    The achievement of passive fit is an important prerequisite for the prevention of complications in full-arch screw-retained implant prosthesis. With cemented prosthesis, the cementation compensates for the discrepancies in the cast framework, but the lack of retrievability seems undesirable. The aim of this paper is to propose a modified screw-retained prosthesis design for complete arch implant fixed rehabilitation. A technique for the fabrication of a full-arch metal-resin implant-supported...

  17. Transcatheter aortic valve prosthesis surgically replaced 4 months after implantation

    DEFF Research Database (Denmark)

    Thyregod, Hans Gustav; Lund, Jens Teglgaard; Engstrøm, Thomas;

    2010-01-01

    Transcatheter aortic valve implantation is a new and rapidly evolving treatment option for high-risk surgical patients with degenerative aortic valve stenosis. Long-term results with these new valve prostheses are lacking, and potential valve dysfunction and failure would require valve replacement....... We report the first case of surgical valve replacement in a patient with a dysfunctional transcatheter-implanted aortic valve prosthesis 4 months after implantation....

  18. Engineering Design of an Adaptive Leg Prosthesis Using Biological Principles

    DEFF Research Database (Denmark)

    Lenau, Torben Anker; Dentel, Andy; Invarsdottir, Thorunn

    2010-01-01

    The biomimetic design process is explored through a design case: An adaptive leg prosthesis. The aim is to investigate if the biomimetic design process can be carried out with a minimum of biological knowledge and without using advanced design methods. In the design case biomimetic design...... was successfully carried out using library search resulting in 14 biological analogies for the design problem 'shape adaption'. It is proposed that search results are handled using special cards describing the biological phenomena and the functional principles....

  19. Cochlear implantation: a biomechanical prosthesis for hearing loss.

    Science.gov (United States)

    Yawn, Robert; Hunter, Jacob B; Sweeney, Alex D; Bennett, Marc L

    2015-01-01

    Cochlear implants are a medical prosthesis used to treat sensorineural deafness, and one of the greatest advances in modern medicine. The following article is an overview of cochlear implant technology. The history of cochlear implantation and the development of modern implant technology will be discussed, as well as current surgical techniques. Research regarding expansion of candidacy, hearing preservation cochlear implantation, and implantation for unilateral deafness are described. Lastly, innovative technology is discussed, including the hybrid cochlear implant and the totally implantable cochlear implant.

  20. Penile Enhancement Procedures with Simultaneous Penile Prosthesis Placement

    Directory of Open Access Journals (Sweden)

    Tariq S. Hakky

    2012-01-01

    Full Text Available Here we present an overview of various techniques performed concomitantly during penile prosthesis surgery to enhance penile length and girth. We report on the technique of ventral phalloplasty and its outcomes along with augmentation corporoplasty, suprapubic lipectomy, suspensory ligament release, and girth enhancement procedures. For the serious implanter, outcomes can be improved by combining the use of techniques for each scar incision. These adjuvant procedures are a key addition in the armamentarium for the serious implant surgeon.

  1. Penile prosthesis implant: scientific advances and technological innovations over the last four decades

    Science.gov (United States)

    2017-01-01

    Despite introduction of oral phosphodiesterase type 5 inhibitors and intracavernosal vasoactive agents, penile prosthesis implant remains a relevant and desired option with sales of penile prostheses continue to stay high, as many men became refractory to medical therapy and/or seeking a more effective and permanent therapy. There are two types of penile prosthesis implants: inflatable and non-inflatable types, and the inflatable penile implants can be subdivided into single-, two- and three-piece devices. Non-inflatable penile prosthesis (non-IPP) may be referred to as semi-rigid rod or malleable prosthesis. IPP is considered a superior option to malleable prosthesis as it produces penile rigidity and flaccidity that closely replicates a normal penile erectile function. Since the introduction of IPP by Scott in 1973, surgical landscape for penile prosthesis implantation has changed dramatically. Advances in prosthesis design, device technologies and surgical techniques have made penile prosthesis implant a more natural, durable and reliable device. The following article reviews the scientific advances and technological innovation in modern penile prosthesis implants over the last four decades. PMID:28217449

  2. Using a Visible Light-Polymerized Resin to Fabricate an Interim Partial Removable Dental Prosthesis.

    Science.gov (United States)

    Segal, Aaron; Yu, Hui Wen; Elkassaby, Heba

    2017-02-01

    An interim partial removable dental prosthesis (RDP) is any dental prosthesis that replaces some teeth in a partially dentate arch designed to enhance esthetics, stabilization, and/or function for a limited period of time, after which it is to be replaced by a definitive dental prosthesis. This article describes a technique that uses a visible light-polymerized (VLP) resin as the base material for an interim partial RDP. This technique can be easily accomplished in a dental office or laboratory and results in a predictable dental prosthesis. This technique eliminates the need for laboratory processing.

  3. Isolated pump erosion of an inflatable penile prosthesis through the scrotum in a diabetic patient

    Directory of Open Access Journals (Sweden)

    Raidh A. Talib

    2013-04-01

    Full Text Available Isolated pump erosion is a rare complication in patients with inflatable penile prosthesis. We describe a case of a diabetic patient who underwent inflatable penile prosthesis implantation with subsequent isolated pump erosion. Repeated attempts of conservative repair of the erosion failed. Finally, the inflatable penile prosthesis was replaced with a malleable one to avoid new pump erosion. In case of isolated pump erosion, replacement of the inflatable penile prosthesis with a malleable one looks to be a good alternative salvage treatment for the patient.

  4. Rehabilitation of digital defect with silicone finger prosthesis: a case report.

    Science.gov (United States)

    Saxena, Deepesh; Jurel, Sunit; Gupta, Ajay; Dhillon, Manu; Tomar, Divya

    2014-08-01

    Patients with acquired defects often had severe trauma which leads to psychological instability, functional loss and poor aesthetics. Digital defects threaten the integrity of one's self esteem and also leads to a reduced and compromised function. A well fitted and colour matched finger prosthesis can make a patient feel a capable person and not a handicap. This article describes a technique for fabrication of custom made finger prosthesis with a silicone elastomer. The customization of the prosthesis leads to a better fit and retention. An excellent shade matching is achieved by the use of intrinsic colours. The other advantages of using silicone as a material of choice for prosthesis fabrication are also discussed.

  5. Use of Powered Prosthesis for Children with Upper Limb Deficiency at Hyogo Rehabilitation Center.

    Directory of Open Access Journals (Sweden)

    Mitsunori Toda

    Full Text Available There has been no research investigating the use of powered prosthetic for children in Japan.To gain better insight into the state of powered prosthesis usage and identify a ratio of rejection among children.Subjects were 37 unilateral below elbow amputees between the ages of 0 and 16 at the time of their first experienced fitting with a powered prosthesis at our Center. The information was collected from medical records and through face-to-face interviews, and we examined rejection rate and the factors affecting the use of powered prosthesis.The rate of discontinuation was 21.6% as 8 of the 37 children stopped using powered prosthesis. All of them were fitted their prosthesis after 2 years of age, and they rejected prosthesis between 5 to 19 years. We found that the level of amputation had no influence on the use of a powered prosthesis.Children fitted before 2 years of age tend to accept their powered prosthesis than those fitted after 2 years. Multidisciprinary team approach, adequate rehabilitation, detailed follow-up and involvement of parents are quite important for introducing powered prosthesis for children.

  6. Abiotrophia defectiva knee prosthesis infection: A case report

    Directory of Open Access Journals (Sweden)

    Levy Pierre-Yves

    2011-09-01

    Full Text Available Abstract Background Abiotrophia species have rarely been implicated in osteoarticular infections. We report one case of an A. defectiva knee prosthesis infection. Case presentation A 71-year-old man of Italian origin presented with pain and swelling of the knee four years after the implantation of a total knee replacement prosthesis. While standard culturing of the synovial fluid resulted in no isolation of microorganisms, the direct inoculation of the synovial fluid into a rich culture medium resulted in the identification of A. defectiva by polymerase chain reaction sequencing. Repeated attempts of culturing microorganisms from blood were negative, and echocardiograms and colonoscopies were unremarkable. High-dose amoxicillin for nine months and a two-stage replacement of the knee prosthesis led to full patient recovery by the time of the 12-month follow-up examination. Conclusions Because Abiotrophia spp. are fastidious microorganisms, it is likely that cases of Abiotrophia orthopedic infection are misdiagnosed as culture-negative infections. Direct inoculation of synovial fluids into rich broth medium and further polymerase chain reaction-based detection of culture-negative synovial fluids are key tests for accurate documentation and detection of these infections.

  7. A multiaxial force-sensing implantable tibial prosthesis.

    Science.gov (United States)

    Kirking, Bryan; Krevolin, Janet; Townsend, Christopher; Colwell, Clifford W; D'Lima, Darryl D

    2006-01-01

    Accurate in vivo measurement of tibiofemoral forces is important in total knee arthroplasty. These forces determine polyethylene stresses and cold-flow, stress distribution in the implant, and stress transfer to the underlying implant bone interface. Theoretic estimates of tibiofemoral forces have varied widely depending on the mathematical models used. The six degrees of freedom of motion, complex articular surface topography, changing joint-contact position, intra- and extra-articular ligaments, number of muscles crossing the knee joint, and the presence of the patellofemoral joint contribute to the difficulty in developing reliable models of the knee. A prototype instrumented total knee replacement tibial prosthesis was designed, manufactured, and tested. This prosthesis accurately measured all six components of tibial forces (R2>0.997). The prosthesis was also instrumented with an internal microtransmitter for wireless data transmission. Remote powering of the sealed implanted electronics was achieved using magnetic coil induction. This device can be used to validate existing models of the knee that estimate these forces or to develop more accurate models. In conjunction with kinematic data, accurate tibiofemoral force data may be used to design more effective knee-testing rigs and wear simulators. Additional uses are intraoperative measurement of forces to determine soft-tissue balancing and to evaluate the effects of rehabilitation, external bracing, and athletic activities, and activities of daily living.

  8. Dental prosthesis aspiration: An uncommon cause of respiratory distress.

    Science.gov (United States)

    De Wilde, Belphine A L; Malfait, Thomas L; Bonte, Katrien; Malfait, Thomas L A

    2016-12-01

    We present a case of a 66-year-old Caucasian man with acute respiratory distress. The patient had a history of multiple cerebrovascular accidents which resulted in left hemiplegia, swallowing problems, and aphasia. He was tentatively diagnosed with aspiration pneumonia. However, because of clinical deterioration further investigations concluded to the aspiration of a dental prosthesis. After intubation and stabilization, the prosthesis could be manually extracted. However, the patient developed a Staphylococcus epidermidis sepsis and despite adequate antibiotic therapy, he eventually died. Dental prosthesis aspiration is a medical situation associated with a higher morbidity and mortality rate compared to ingested foreign bodies. It requires a high level of suspicion to ensure a timely diagnosis and life-saving treatment. Thorough history taking is of great importance in case of tracheobronchial aspiration, which is in the adult population mostly secondary to an underlying disorder. In impaired adults with missing dental prostheses there should be extra awareness for this problem. This case report illustrates the importance of a detailed history in case of tracheobronchial aspiration and shows the limitations in the diagnostic usefulness of bedside chest radiography.

  9. Reconstruction of chronic acromioclavicular joint disruption with artificial ligament prosthesis

    Institute of Scientific and Technical Information of China (English)

    Devendra Kumar Chouhan; Uttam Chand Saini; Mandeep Singh Dhillon

    2013-01-01

    Objective:Management of Rockwood type 3 acromioclavicular disruptions is a matter of debate.Should we adopt conservative or operative measures at first presentation? It is not clear but most of the evidences are in favour of conservative management.We present our experience in managing these patients surgically.Methods:We present a prospective series of eight cases of chronic Rockwood type 3 acromioclavicular joint disruptions treated surgically.Anatomical reconstruction of the coracoclavicular ligament was done by artificial braided polyester ligament prosthesis.Results:All the patients were able to perform daily activities from an average of the 14th postoperative day.All patients felt an improvement in pain,with decrease in average visual analogue scale from preoperative 6.5 points (range 3-9 points) to 2.0 points (range 0-5 points),Constant score from 59% to 91% and American Shoulder and Elbow Surgeons shoulder score from 65 to 93 points postoperatively.These results improved or at least remained stationary on midterm follow-up,and no deterioration was recorded at an average follow-up of 46 months.Conclusion:This midterm outcome analysis of the artificial ligament prosthesis is the first such follow-up study with prosthesis.Our results are encouraging and justify the further use and evaluation of this relatively new and easily reproducible technique.

  10. A cortical neural prosthesis for restoring and enhancing memory

    Science.gov (United States)

    Berger, Theodore W.; Hampson, Robert E.; Song, Dong; Goonawardena, Anushka; Marmarelis, Vasilis Z.; Deadwyler, Sam A.

    2011-08-01

    A primary objective in developing a neural prosthesis is to replace neural circuitry in the brain that no longer functions appropriately. Such a goal requires artificial reconstruction of neuron-to-neuron connections in a way that can be recognized by the remaining normal circuitry, and that promotes appropriate interaction. In this study, the application of a specially designed neural prosthesis using a multi-input/multi-output (MIMO) nonlinear model is demonstrated by using trains of electrical stimulation pulses to substitute for MIMO model derived ensemble firing patterns. Ensembles of CA3 and CA1 hippocampal neurons, recorded from rats performing a delayed-nonmatch-to-sample (DNMS) memory task, exhibited successful encoding of trial-specific sample lever information in the form of different spatiotemporal firing patterns. MIMO patterns, identified online and in real-time, were employed within a closed-loop behavioral paradigm. Results showed that the model was able to predict successful performance on the same trial. Also, MIMO model-derived patterns, delivered as electrical stimulation to the same electrodes, improved performance under normal testing conditions and, more importantly, were capable of recovering performance when delivered to animals with ensemble hippocampal activity compromised by pharmacologic blockade of synaptic transmission. These integrated experimental-modeling studies show for the first time that, with sufficient information about the neural coding of memories, a neural prosthesis capable of real-time diagnosis and manipulation of the encoding process can restore and even enhance cognitive, mnemonic processes.

  11. Modified cementless total coxofemoral prosthesis: development, implantation and clinical evaluation

    Directory of Open Access Journals (Sweden)

    S.A. Arias

    2013-12-01

    Full Text Available The aim of this study was to modify canine coxofemoral prostheses and the clinical evaluation of the implantation. Fifteen canine hips and femora of cadavers were used in order to study the surface points of modification in prostheses and develop a perforation guide. Femoral stems and acetabular components were perforated and coated with biphasic calcium phosphate layer. Twelve young adult male mongrel dogs were implanted with coxofemoral prostheses. Six were operated upon and implanted with cemented canine modular hip prostheses, establishing the control group. The remaining six were implanted with a novel design of cementless porous tricalcic phosphate-hydroxyapatite coated hip prostheses. Clinical and orthopedic performance, complications, and thigh muscular hypotrophy were assessed up to the 120th post-operatory day. After 120 days, animals with cementless prostheses had similar clinical and orthopedic performance compared to the cemented group despite the increased pain thigh hypotrophy. Animals that underwent cementless hip prosthesis evidenced more pain, compared to animals with cemented hip prosthesis that required longer recuperation time. No luxations, two fractures and two isquiatic neurapraxies were identified in the course of the study. Using both the cemented and the bioactive coated cementless model were suitable to dogs, showing clinical satisfactory results. Osseointegration and biological fixation were observed in the animals with the modified cementless hip prosthesis.

  12. Literature Review on Needs of Upper Limb Prosthesis Users.

    Science.gov (United States)

    Cordella, Francesca; Ciancio, Anna Lisa; Sacchetti, Rinaldo; Davalli, Angelo; Cutti, Andrea Giovanni; Guglielmelli, Eugenio; Zollo, Loredana

    2016-01-01

    The loss of one hand can significantly affect the level of autonomy and the capability of performing daily living, working and social activities. The current prosthetic solutions contribute in a poor way to overcome these problems due to limitations in the interfaces adopted for controlling the prosthesis and to the lack of force or tactile feedback, thus limiting hand grasp capabilities. This paper presents a literature review on needs analysis of upper limb prosthesis users, and points out the main critical aspects of the current prosthetic solutions, in terms of users satisfaction and activities of daily living they would like to perform with the prosthetic device. The ultimate goal is to provide design inputs in the prosthetic field and, contemporary, increase user satisfaction rates and reduce device abandonment. A list of requirements for upper limb prostheses is proposed, grounded on the performed analysis on user needs. It wants to (i) provide guidelines for improving the level of acceptability and usefulness of the prosthesis, by accounting for hand functional and technical aspects; (ii) propose a control architecture of PNS-based prosthetic systems able to satisfy the analyzed user wishes; (iii) provide hints for improving the quality of the methods (e.g., questionnaires) adopted for understanding the user satisfaction with their prostheses.

  13. TOTAL ANKLE ARTHROPLASTY: BRAZILIAN EXPERIENCE WITH THE HINTEGRA PROSTHESIS.

    Science.gov (United States)

    Nery, Caio; Fernandes, Túlio Diniz; Réssio, Cibele; Fuchs, Mauro Luiz; Godoy Santos, Alexandre Leme de; Ortiz, Rafael Trevisan

    2010-01-01

    Ankle arthrosis is becoming more and more common. The search for solutions that preserve joint function has led to a new generation of prosthesis with three components and more degrees of freedom. This paper presents the results achieved for ten patients treated with the HINTEGRA Prosthesis (Integra, New Deal), through collaborative action between the Foot and Ankle Groups of the Orthopedics and Traumatology divisions of Escola Paulista de Medicina, Unifesp, and the School of Medicine of the University of São Paulo (USP). The ten patients (six women and four men, aged between 29 and 66 years), underwent a surgical procedure consisting of Hintermann's technique, between January and June 2005. They were evaluated at prearranged intervals, and the data were subjected to statistical analysis. The surgery led to a significant improvement in ankle mobility. Radiological evaluation showed no signs of loosening or failure in the prosthetic components in any of the patients studied. Although the complication rate in our sample was high, it was equivalent to the rates found by other authors, and directly represents the learning curve associate with this kind of procedure. Four years after the procedure, it was found that the patients pain levels had significantly decreased, and that their functional patterns had significantly improved, with AOFAS and Hintermann scores indicating results that were excellent for 20%, good for 70% and poor for 10%. Treatment of ankle arthritis by means of total arthroplasty using the HINTEGRA prosthesis was capable of providing good results over an average observation period of four years.

  14. Impact of removable partial denture prosthesis on chewing efficiency

    Directory of Open Access Journals (Sweden)

    Marion Bessadet

    2013-09-01

    Full Text Available Removable partial denture prostheses are still being used for anatomic, medical and economic reasons. However, the impact on chewing parameters is poorly described. OBJECTIVES: The objective of this study was to estimate the impact of removable partial denture prosthesis on masticatory parameters. MATERIAL AND METHODS: Nineteen removable partial denture prosthesis (RPDP wearers participated in the study. Among them, 10 subjects were Kennedy Class III partially edentulous and 9 with posterior edentulism (Class I. All presented a complete and full dentate opposing arch. The subjects chewed samples of carrots and peanuts with and without their prosthesis. The granulometry of the expectorated boluses from carrot and peanuts was characterized by median particle size (D50, determined at the natural point of swallowing. Number of chewing cycles (CC, chewing time (CT and chewing frequency (CF=CC/CT were video recorded. RESULTS: With RPDP, the mean D50 values for carrot and peanuts were lower [Repeated Model Procedures (RMP, F=15, p<0.001] regardless of the type of Kennedy Class. For each food, mean CC, CT and CF values recorded decreased (RMP, F=18, F=9, and F=20 respectively, p<0.01. With or without RPD, the boluses' granulometry values were above the masticatory normative index (MNI determined as 4,000 µm. CONCLUSION: RPDP rehabilitation improves the ability to reduce the bolus particle size, but does not reestablish fully the masticatory function. CLINICAL RELEVANCE: This study encourages the clinical improvement of oral rehabilitation procedure.

  15. Reliability of MRI findings in candidates for lumbar disc prosthesis

    Energy Technology Data Exchange (ETDEWEB)

    Berg, Linda; Espeland, Ansgar [Haukeland University Hospital, Department of Radiology, Bergen (Norway); University of Bergen, Section for Radiology, Department of Surgical Sciences, Bergen (Norway); Neckelmann, Gesche [Haukeland University Hospital, Department of Radiology, Bergen (Norway); Gjertsen, Oeivind [Oslo University Hospital, Department of Neuroradiology, Oslo (Norway); Hellum, Christian [Oslo University Hospital, Department of Orthopaedics, Oslo (Norway); University of Oslo, Department of Orthopaedics, Oslo (Norway); Johnsen, Lars G. [University Hospital of Trondheim, National Centre for Diseases of the Spine, Trondheim (Norway); University Hospital of Trondheim, Orthopaedic Department, Trondheim (Norway); Eide, Geir E. [Haukeland University Hospital, Centre for Clinical Research, Bergen (Norway); University of Bergen, Department of Public Health and Primary Health Care, Bergen (Norway)

    2012-07-15

    Limited reliability data exist for localised magnetic resonance imaging (MRI) findings relevant to planning of treatment with lumbar disc prosthesis and later outcomes. We assessed the reliability of such findings in chronic low back pain patients who were accepted candidates for disc prosthesis. On pretreatment MRI of 170 patients (mean age 41 years; 88 women), three experienced radiologists independently rated Modic changes, disc findings and facet arthropathy at L3/L4, L4/L5 and L5/S1. Two radiologists rerated 126 examinations. For each MRI finding at each disc level, agreement was analysed using the kappa statistic and differences in prevalence across observers using a fixed effects model. All findings at L3/L4 and facet arthropathy at L5/S1 had a mean prevalence <10% across observers and were not further analysed, ensuring interpretable kappa values. Overall interobserver agreement was generally moderate or good (kappa 0.40-0.77) at L4-S1 for Modic changes, nucleus pulposus signal, disc height (subjective and measured), posterior high-intensity zone (HIZ) and disc contour, and fair (kappa 0.24) at L4/L5 for facet arthropathy. Posterior HIZ at L5/S1 and severely reduced subjective disc height at L4/L5 differed up to threefold in prevalence between observers (p < 0.0001). Intraobserver agreement was mostly good or very good (kappa 0.60-1.00). In candidates for disc prosthesis, mostly moderate interobserver agreement is expected for localised MRI findings. (orig.)

  16. Structure and energetic characteristics of methane hydrates. From single cage to triple cage: A DFT-D study

    Science.gov (United States)

    Giricheva, N. I.; Ischenko, A. A.; Yusupov, V. I.; Bagratashvili, V. N.; Girichev, G. V.

    2017-03-01

    Electronic, geometrical, vibrational and energetic characteristics of the ice I TDT fragment consisted of dodecahedron H2O[512] (D) fused with two tetrakaidecahedrons H2O[51262] (T) and of the TDT cluster with three encapsulated CH4 molecules (3CH4·TDT) were calculated using a DFT/B97-D/6-311++G(2d,2p) approach. Binding energies, hydrogen bonding energies, energies of encapsulation of methane molecules into small D- and large T-cages of the TDT fragment, energies of frontier orbitals, the translational and librational frequencies, as well as the intramolecular vibrations of methane within the cages of different sizes were studied. Similar characteristics of isolated D- and T-cages and clathrates CH4·D and CH4·T were studied as function of compression/expansion of their oxygen skeletons using DFT/B97-D, LC-B3LYP, B3LYP-D2 methods.

  17. Flow Field Characteristics of the Rotor Cage in Turbo Air Classifiers

    Institute of Scientific and Technical Information of China (English)

    GUO Lijie; LIU Jiaxiang; LIU Shengzhao

    2009-01-01

    The turbo air classifier is widely used powder classification equipment in a variety of fields. The flow field characteristics of the turbo air classifier are important basis for the improvement of the turbo air classifier's structural design. The flow field characteristics of the rotor cage in turbo air classifiers were investigated under different operating conditions by laser Doppler velocimeter(LDV), and a measure diminishing the axial velocity is proposed. The investigation results show that the tangential velocity of the air flow inside the rotor cage is different from the rotary speed of the rotor cage on the same measurement point due to the influences of both the negative pressure at the exit and the rotation of the rotor cage. The tangential velocity of the air flow likewise decreases as the radius decreases in the case of the rotor cage's low rotary speed. In contrast, the tangential velocity of the air flow increases as the radius decreases in the case of the rotor cage's high rotary speed. Meanwhile, the vortex inside the rotor cage is found to occur near the pressure side of the blade when the rotor cage's rotary speed is less than the tangential velocity of air flow. On the contrary, the vortex is found to occur near the blade suction side once the rotor cage's rotary speed is higher than the tangential velocity of air flow. Inside the rotor cage, the axial velocity could not be disregarded and is largely determined by the distances between the measurement point and the exit.

  18. Ocular prosthesis incorporating IPS e-max press scleral veneer and a literature review on non-integrated ocular prosthesis

    Science.gov (United States)

    Da Costa, Godwin Clovis; Aras, Meena Ajay; Chalakkal, Paul; Da Costa, Michelle Clovis

    2017-01-01

    The article highlights a new method for the fabrication of an ocular prosthesis by the incorporation of a ceramic scleral veneer. The steps of fabrication include impression making, wax try-in, performing a “cut-back” on a selected stock eye, insertion of the IPS e-max press scleral veneer, finishing and insertion. It also includes a detailed review on non-integrated ocular prostheses. PMID:28149792

  19. Ocular prosthesis incorporating IPS e-max press scleral veneer and a literature review on non-integrated ocular prosthesis.

    Science.gov (United States)

    Da Costa, Godwin Clovis; Aras, Meena Ajay; Chalakkal, Paul; Da Costa, Michelle Clovis

    2017-01-01

    The article highlights a new method for the fabrication of an ocular prosthesis by the incorporation of a ceramic scleral veneer. The steps of fabrication include impression making, wax try-in, performing a "cut-back" on a selected stock eye, insertion of the IPS e-max press scleral veneer, finishing and insertion. It also includes a detailed review on non-integrated ocular prostheses.

  20. Effects of Furnished Cage Type on Behavior and Welfare of Laying Hens.

    Science.gov (United States)

    Li, Xiang; Chen, Donghua; Li, Jianhong; Bao, Jun

    2016-06-01

    This study was conducted to compare the effects of layout of furniture (a perch, nest, and sandbox) in cages on behavior and welfare of hens. Two hundred and sixteen Hyline Brown laying hens were divided into five groups (treatments) with four replicates per group: small furnished cages (SFC), medium furnished cages type I (MFC-I), medium furnished cages type II (MFC-II), and medium furnished cages type III (MFC-III) and conventional cages (CC). The experiment started at 18 week of age and finished at 52 week of age. Hens' behaviors were filmed during the following periods: 8:00 to 10:00; 13:00 to 14:00; 16:00 to 17:00 on three separate days and two hens from each cage were measured for welfare parameters at 50 wk of age. The results showed that feeding and laying of all hens showed no effect by cage type (p>0.05), and the hens in the furnished cages had significantly lower standing and higher walking than CC hens (p0.05). The hens in MFC-I, -II, and -III showed a significant higher socializing behavior than SFC and CC (p<0.05). The lowest perching was for the hens in SFC and the highest perching found for the hens in MFC-III. Overall, the hens in CC showed poorer welfare conditions than the furnished cages, in which the feather condition score, gait score and tonic immobility duration of the hens in CC was significantly higher than SFC, MFC-I, MFC-II, and MFC-III (p<0.05). In conclusion, the furnished cage design affected both behavior and welfare states of hens. Overall, MFC-III cage design was better than SFC, MFC-I, and MFC-II cage designs.

  1. Treatment of sharp mandibular alveolar process with hybrid prosthesis

    Directory of Open Access Journals (Sweden)

    Sukaedi Sukaedi

    2010-09-01

    Full Text Available Background: Losing posterior teeth for a long time would occasionally lead to the sharpening of alveolar process. The removable partial denture usually have problems when used during mastication, because of the pressure on the mucosa under the alveolar ridge. Purpose: The purpose of this case report was to manage patients with sharp mandibular alveolar process by wearing hybrid prosthesis with extra coronal precision attachment retention and soft liner on the surface base beneath the removable partial denture. Case: A 76 years old woman visited the Prosthodontic Clinic Faculty of Dentistry Airlangga University. The patient had a long span bridge on the upper jaw and a free end acrylic removable partial denture on the lower jaw. She was having problems with mastication. The patient did not wear her lower denture because of the discomfort with it during mastication. Hence, she would like to replace it with a new removable partial denture. Case management: The patient was treated by wearing a hybrid prosthesis with extra coronal precision attachment on the lower jaw. Soft liner was applied on the surface of the removable partial denture. Hybrid prosthesis is a complex denture consisting of removable partial denture and fixed bridge. Conclusion: It concluded that after restoration, the patient had no problems with sharp alveolar process with her new denture, and she was able to masticate well.Latar belakang: Kehilangan geligi posterior dapat menimbulkan processus alveolaris tajam. Gigi tiruan sebagian lepasan mempunyai masalah selama pengunyahan karena adanya tekanan di mukosa di bawah alveolar ridge. Tujuan: Tujuan laporan kasus ini adalah untuk menjelaskan cara menangani pasien yang mempunyai prosesus alveolaris yang tajam di rahang bawah dengan dibuatkan protesis hybrid dengan daya tahan extra coronal precision attachment dan soft liner di permukaan bawah basis gigi tiruan sebagian lepasan. Kasus: Pasien wanita berumur 76 tahun datang di klinik

  2. Design and performance of a double-tuned bird-cage coil

    Science.gov (United States)

    Rath, Alan R.

    The "high-pass" and "low-pass" designations commonly given to bird-cage coils derive in each case from the relationship of the individual sections of the bird cage to simple filters. By extension of the concept of constructing a bird-cage coil from elementary filter sections, it is possible to create coils which support "bird-cage mode" resonances at more than one frequency. Designs based on both simple bandpass and band-stop filters, for example, provide means to realize bird-cage coils which may be tuned simultaneously to two frequencies. Construction and performance of a band-stop bird cage operating at both 200 and 81 MHz are described.

  3. Design And Development Of Roll Cage For An All-Terrain Vehicle

    Directory of Open Access Journals (Sweden)

    Khelan Chaudhari

    2013-12-01

    Full Text Available The study aims to design, develop and fabricate a roll cage for an All-Terrain Vehicle (ATV in accordance with the rulebook of BAJA 2013 given by SAE. A roll cage is a skeleton of an ATV. The roll cage not only forms the structural base but also a 3-D shell surrounding the occupant which protects the occupant in case of impact and roll over incidents. The roll cage also adds to the aesthetics of a vehicle. The design and development comprises of material selection, chassis and frame design, cross section determination, determining strength requirements of roll cage, stress analysis and simulations to test the ATV against failure. Finally the roll cage is fabricated as per the tools and techniques available in the workshop.

  4. Synthesis and photochemical properties of PEGylated coumarin-caged ceramides for cell studies.

    Science.gov (United States)

    Kim, Young Ah; Day, Jenna; Lirette, Carol Ann; Costain, Willard J; Johnston, Linda J; Bittman, Robert

    2016-01-01

    Caged ceramide analogues (C6-, C16-, C18-, C22- and C24-Cer) have been prepared by introducing a hydrophilic coumarin-based cage bearing a short polyethylene glycol (PEG) chain. (6-Bromo-7-mTEGylated-coumarin-4-yl)methyl (Btc) caged ceramide showed efficient photo-uncaging to release the parent ceramide upon direct exposure to 350 nm UV light; in contrast (7-mTEGylated-coumarin-4-yl)methyl (Tc) caged ceramide was photolysed more slowly. In preliminary experiments, Btc-caged ceramides were taken up by cells and their photolysis led to decreases in cell viability, but not to activation of caspase enzymes, suggesting that either reactive oxygen species or an alternate caspase-independent pathway may be responsible for the decreases in cell viability caused by photolysis of caged ceramides.

  5. Greenhouse Gas Emissions from Three Cage Layer Housing Systems

    Directory of Open Access Journals (Sweden)

    John Feddes

    2011-12-01

    Full Text Available Agriculture accounts for 10 to 12% of the World’s total greenhouse gas (GHG emissions. Manure management alone is responsible for 13% of GHG emissions from the agricultural sector. During the last decade, Québec’s egg production systems have shifted from deep-pit housing systems to manure belt housing systems. The objective of this study was to measure and compare carbon dioxide (CO2, methane (CH4 and nitrous oxide (N2O emissions from three different cage layer housing systems: a deep liquid manure pit and a manure belt with natural or forced air drying. Deep liquid manure pit housing systems consist of “A” frame layer cages located over a closed pit containing the hens’ droppings to which water is added to facilitate removal by pumping. Manure belt techniques imply that manure drops on a belt beneath each row of battery cages where it is either dried naturally or by forced air until it is removed. The experiment was replicated with 360 hens reared into twelve independent bench-scale rooms during eight weeks (19–27 weeks of age. The natural and forced air manure belt systems reduced CO2 (28.2 and 28.7 kg yr−1 hen−1, respectively, CH4 (25.3 and 27.7 g yr−1 hen−1, respectively and N2O (2.60 and 2.48 g yr−1 hen−1, respectively emissions by about 21, 16 and 9% in comparison with the deep-pit technique (36.0 kg CO2 yr−1 hen−1, 31.6 g CH4 yr−1 hen−1 and 2.78 g N2O yr−1 hen−1. The shift to manure belt systems needs to be encouraged since this housing system significantly decreases the production of GHG.

  6. Effect of steerable cage placement during minimally invasive transforaminal lumbar interbody fusion on lumbar lordosis.

    Science.gov (United States)

    Lindley, Timothy E; Viljoen, Stephanus V; Dahdaleh, Nader S

    2014-03-01

    Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is commonly used for the treatment of a variety of degenerative spine disorders. Recently, steerable interbody cages have been developed which potentially allow for greater restoration of lumbar lordosis. Here we describe a technique and radiographic results following minimally invasive placement of steerable cages through a bilateral approach. A retrospective review was conducted of the charts and radiographs of 15 consecutive patients who underwent 19 levels of bilateral MIS-TLIF with the placement of steerable cages. These were compared to 10 patients who underwent 16 levels of unilateral MIS-TLIF with the placement of bullet cages. The average age, body mass index, distribution of the levels operated and follow-up were similar in both groups. The average height of the steerable cage placed was 10.9 mm compared to 8.5mm for bullet cages. The preoperative focal Cobb's angle per level was similar between both groups with a mean of -5.3 degrees for the steerable cage group and -4.8 degrees for the bullet cage group. There was a significant improvement in postoperative Cobb's angle after placement of a steerable cage with a mean of -13.7 (p<0.01) and this persisted at the last follow-up with -13 degrees (p<0.01). There was no significant change in Cobb's angle after bullet cage placement with -5.7 degrees postoperatively and a return to the baseline preoperative Cobb's angle of -4.8 at the last follow-up. Steerable cage placement for MIS-TLIF improves focal lordosis compared to bullet cage placement.

  7. Are assemblages of the fireworm Hermodice carunculata enhanced in sediments beneath offshore fish cages?

    Institute of Scientific and Technical Information of China (English)

    Rodrigo Riera; Oscar Prez; Myriam Rodrguez; Eva Ramos; scar Monterroso

    2014-01-01

    Abundances of the fireworm Hermodice carunculata were counted through a monitoring assessment study of fish cages in Barranco Hondo (NE Tenerife). Seven campaigns were conducted from November 2007 to June 2010 and temporal variations were found, as well as differences among sampling stations. The poly-chaete H. carunculata obtained its highest abundance in sediments beneath fish cages throughout the study period. Thus, the assemblages of this omnivorous species were favoured by the presence of fish cages.

  8. Shape assisted fabrication of fluorescent cages of squarate based metal-organic coordination frameworks.

    Science.gov (United States)

    Jayaramulu, Kolleboyina; Krishna, Katla Sai; George, Subi J; Eswaramoorthy, Muthuswamy; Maji, Tapas Kumar

    2013-05-11

    Micronic cage structures of squarate based metal-organic coordination frameworks (MOCFs) have been fabricated for the first time by specific anion selective etching of metal squarate cubes. Time and stoichiometry dependent synthesis and the corresponding microscopic studies have provided mechanistic insight into the cage formation. Furthermore, a non-covalent post-synthetic strategy has been adopted to functionalize the micronic cubes or cages with chromophores rendering the resulting hybrids green fluorescent.

  9. Regioselective nitration of aromatic substrates in zeolite cages

    Indian Academy of Sciences (India)

    T Esakkidurai; M Kumarraja; K Pitchumani

    2003-04-01

    Phenol is nitrated regioselectively by fuming nitric acid inside the cages of faujasite zeolites (dependent on the loading level) and a remarkable orthoselectivity is observed in solid state nitration. Toluene and chlorobenzene also containing ortho-/para-orienting substituents, undergo faster nitration, though the regioselectivity is less significant in zeolite media. The results are explained on the basis of diffusion and binding of phenol inside zeolite, which facilitate regioselectivity (and which is absent in toluene and chlorobenzene). Other advantages of employing zeolites as media for mild and selective nitration are also highlighted.

  10. Bambusurils as effective ion caging agents: Does desolvation guide conformation?

    Science.gov (United States)

    Cova, Tânia F. G. G.; Nunes, Sandra C. C.; Pinho e Melo, Teresa M. V. D.; Pais, Alberto A. C. C.

    2017-03-01

    Water soluble bambusurils can bind and isolate inorganic anions in the center of the hydrophobic cavity, with high affinity and selectivity. This makes them appealing anion carriers and ion transporters for a wide range of biomedical applications, including in ion-channel diseases of the muscles, bones and brain. For understanding the bambusuril ion caging ability in aqueous media, molecular dynamics simulations, including free energy calculations are used. It is seen that the ion is hermetically sealed inside the cavity, as a result of a concerted action involving conformation and desolvation of both ion and bambusuril cavity.

  11. SAMURAI-TPC: Field Cage Design and Prototyping

    Science.gov (United States)

    Lu, F.; Barney, J.; Chajecki, Z.; Chan, C. F.; Dunn, J. W.; Estee, J.; Gilbert, J.; Lynch, W. G.; Shane, R.; Tsang, M. B.; McIntosh, A. B.; Yenello, S. J.; Famiano, M.; Isobe, T.; Sakurai, H.; Taketani, A.; Murakami, T.; Samurai-Tpc Collaboration

    2011-10-01

    The SAMURAI-TPC is a time-projection chamber to be used in conjunction with the SAMURAI spectrometer being built at the Radioactive Isotope Beam Facility at RIKEN, Japan. It will be used to measure charged pions, protons and light ions. The pi+/pi- ratios from heavy-ion collisions should provide constraints on the asymmetry term in the nuclear equation of state at densities about twice saturation density. In this talk, the design and operation of the field cage, an essential part of the detector, will be discussed, along with the results of prototype testing. This work is supported by the Department of Energy under Grant DE-SC0004835.

  12. Concerning the Optimal Salt Bridge for Trp-cage Stabilization†

    Science.gov (United States)

    Williams, D. Victoria; Byrne, Aimee; Stewart, James; Andersen, Niels H.

    2011-01-01

    Gai and co-workers (Bunagan, M. R. (2006) J. Phys. Chem. B 110, 3759-3763) reported computational design studies suggesting that a D9E mutation would stabilize the Trp-cage. Experimental studies for this mutation were reported in 2008 (Hudaky, P. (2008) Biochemistry 47, 1007-1016); the authors suggested that [D9E]-TC5b presented a more compact, and melting resistant structure due to the “optimal distance between the two sides of the molecule”. Nonetheless, the authors reported essentially the same CD melting temperature, 38±0.3 °C, for TC5b and its [D9E] mutant. In this study, a more stable Trp-cage, DAYAQ WLKDG GPSSG RPPPS, was examined by NMR and CD with the following mutations: [D9E], [D9R,R16E], [R16Orn], [D9E,R16Orn], [R16K], and [D9E,R16K]. Of these, the [D9E]-mutant displayed the smallest acidification induced change in the apparent Tm. In analogy to the prior study, the CD melts of TC10b and its [D9E] mutant were, however, very similar; all of the other mutations were significantly fold destabilizing by all measures. A detailed analysis indicates that the original D9/R16 salt bridge is optimal with regard to fold cooperativity and fold stabilization. Evidence for salt-bridging is also provided for a swapped pair, the [D9R,R16E]-mutant. Model systems reveal that an ionized aspartate at the C-terminus of a helix significantly decreases intrinsic helicity, a requirement for Trp-cage fold stability. The CD evidence which was cited as supporting increased fold stability for the [D9E]-TC5b at higher temperatures appears to be a reflection of increased helix stability in both the folded and unfolded state rather than a more favorable salt bridge. The present study also provides evidence for other Trp-cage stabilizing roles of the R16 sidechain. PMID:21222485

  13. Design of Automated Rotory Cage Type Fixture for Cylinder Block

    Directory of Open Access Journals (Sweden)

    Y.S.Kapnichor

    2014-08-01

    Full Text Available Project gives feasible solution to move and rotate the component with full proofing fixturing for special purpose operations like drilling, Tapping, deburring, washing, drying involve in manufacturing and assembly unit of industry. Rotary cage type fixture is made for handling the cylinder head inside the cleaning machine use for making fully ready component before assembly operation .System is useful to save time manpower and deliver perfect cleaned and dry component .system involved all the mechanical components along with the sensors used to restrict the rotating operations, stop and go operations etc.

  14. Preinjector for Linac 1, inside the Faraday cage

    CERN Multimedia

    1974-01-01

    For a description of the Linac 1 preinjector, please see first 7403070X. Here, the view is towards the upper level of the Faraday cage. Far to the right, a technician is peering through the service door. The huge box-shaped cubicle is the electronics platform, at 520 kV potential during operation. The "bull eye" at the left back sits at the top end of the accelerating column (see 7403081X) and houses the ion source with its electronics (see 7403083X). The SAMES generator, providing the 520 kV HV (7403074) sits on the floor and is not visible here.

  15. 21 CFR 888.3410 - Hip joint metal/polymer or ceramic/polymer semiconstrained resurfacing cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... semiconstrained resurfacing cemented prosthesis. 888.3410 Section 888.3410 Food and Drugs FOOD AND DRUG... prosthesis. (a) Identification. A hip joint metal/polymer or ceramic/polymer semi-constrained resurfacing cemented prosthesis is a two-part device intended to be implanted to replace the articulating surfaces...

  16. 21 CFR 888.3380 - Hip joint femoral (hemi-hip) trunnion-bearing metal/polyacetal cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... metal/polyacetal cemented prosthesis. 888.3380 Section 888.3380 Food and Drugs FOOD AND DRUG... Devices § 888.3380 Hip joint femoral (hemi-hip) trunnion-bearing metal/polyacetal cemented prosthesis. (a) Identification. A hip joint femoral (hemi-hip) trunnion-bearing metal/polyacetal cemented prosthesis is a...

  17. 21 CFR 888.3640 - Shoulder joint metal/metal or metal/polymer constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... constrained cemented prosthesis. 888.3640 Section 888.3640 Food and Drugs FOOD AND DRUG ADMINISTRATION... § 888.3640 Shoulder joint metal/metal or metal/polymer constrained cemented prosthesis. (a) Identification. A shoulder joint metal/metal or metal/polymer constrained cemented prosthesis is a...

  18. 21 CFR 888.3390 - Hip joint femoral (hemi-hip) metal/polymer cemented or uncemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... cemented or uncemented prosthesis. 888.3390 Section 888.3390 Food and Drugs FOOD AND DRUG ADMINISTRATION... § 888.3390 Hip joint femoral (hemi-hip) metal/polymer cemented or uncemented prosthesis. (a) Identification. A hip joint femoral (hemi-hip) metal/polymer cemented or uncemented prosthesis is a...

  19. 21 CFR 888.3320 - Hip joint metal/metal semi-constrained, with a cemented acetabular component, prosthesis.

    Science.gov (United States)

    2010-04-01

    ... cemented acetabular component, prosthesis. 888.3320 Section 888.3320 Food and Drugs FOOD AND DRUG..., prosthesis. (a) Identification. A hip joint metal/metal semi-constrained, with a cemented acetabular component, prosthesis is a two-part device intended to be implanted to replace a hip joint. The...

  20. 21 CFR 888.3353 - Hip joint metal/ceramic/polymer semi-constrained cemented or nonporous uncemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... cemented or nonporous uncemented prosthesis. 888.3353 Section 888.3353 Food and Drugs FOOD AND DRUG... prosthesis. (a) Identification. A hip joint metal/ceramic/polymer semi-constrained cemented or nonporous uncemented prosthesis is a device intended to be implanted to replace a hip joint. This device...

  1. 21 CFR 888.3358 - Hip joint metal/polymer/metal semi-constrained porous-coated uncemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... porous-coated uncemented prosthesis. 888.3358 Section 888.3358 Food and Drugs FOOD AND DRUG... Devices § 888.3358 Hip joint metal/polymer/metal semi-constrained porous-coated uncemented prosthesis. (a) Identification. A hip joint metal/polymer/metal semi-constrained porous-coated uncemented prosthesis is a...

  2. 21 CFR 888.3330 - Hip joint metal/metal semi-constrained, with an uncemented acetabular component, prosthesis.

    Science.gov (United States)

    2010-04-01

    ... uncemented acetabular component, prosthesis. 888.3330 Section 888.3330 Food and Drugs FOOD AND DRUG..., prosthesis. (a) Identification. A hip joint metal/metal semi-constrained, with an uncemented acetabular component, prosthesis is a two-part device intended to be implanted to replace a hip joint. The...

  3. Prosthetic replacement of the medial meniscus in cadaveric knees: does the prosthesis mimic the functional behavior of the native meniscus?

    NARCIS (Netherlands)

    Tienen, T.G. van; Verdonschot, N.J.J.; Heijkants, R.G.J.C.; Buma, P.; Scholten, J.G.; Kampen, A. van; Veth, R.P.H.

    2004-01-01

    Meniscus replacement by a polymer meniscus prosthesis in dogs resulted in generation of new meniscal tissue. HYPOTHESIS: Optimal functioning of the prosthesis would involve realistic deformation and motion patterns of the prosthesis during knee joint motion. STUDY DESIGN: Controlled laboratory study

  4. Prosthetic replacement of the medial meniscus in cadaveric knees - Does the prosthesis mimic the functional behavior of the native meniscus?

    NARCIS (Netherlands)

    Tienen, TG; Verdonschot, N; Heijkants, RGJC; Buma, R; Scholten, JGF; van Kampen, A; Veth, RPH

    2004-01-01

    Meniscus replacement by a polymer meniscus prosthesis in dogs resulted in generation of new meniscal tissue. Hypothesis: Optimal functioning of the prosthesis would involve realistic deformation and motion patterns of the prosthesis during knee joint motion. Study Design: Controlled laboratory study

  5. Numerical analysis of an osseointegrated prosthesis fixation with reduced bone failure risk and periprosthetic bone loss

    NARCIS (Netherlands)

    Tomaszewski, P. M.; van Diest, M.; Bulstra, S. K.; Verdonschot, N.; Verkerke, G. J.

    2012-01-01

    Currently available implants for direct attachment of prosthesis to the skeletal system after transfemoral amputation (OPRA system. Integrum AB, Sweden and ISP Endo/Exo prosthesis, ESKA Implants AG, Germany) show many advantages over the conventional socket fixation. However, restraining biomechanic

  6. Numerical analysis of an osseointegrated prosthesis fixation with reduced bone failure risk and periprosthetic bone loss.

    NARCIS (Netherlands)

    Tomaszewski, P.K.; Diest, M. van; Bulstra, S.K.; Verdonschot, N.J.; Verkerke, G.J.

    2012-01-01

    Currently available implants for direct attachment of prosthesis to the skeletal system after transfemoral amputation (OPRA system, Integrum AB, Sweden and ISP Endo/Exo prosthesis, ESKA Implants AG, Germany) show many advantages over the conventional socket fixation. However, restraining biomechanic

  7. 21 CFR 888.3810 - Wrist joint ulnar (hemi-wrist) polymer prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Wrist joint ulnar (hemi-wrist) polymer prosthesis. 888.3810 Section 888.3810 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... (hemi-wrist) polymer prosthesis. (a) Identification. A wrist joint ulnar (hemi-wrist) polymer...

  8. Development of a cosmetic knee disarticulation prosthesis : A single-patient case study

    NARCIS (Netherlands)

    de Laat, Fred A.; de Vos, Wouter; Geertzen, Jan; Roorda, Leo D.

    2015-01-01

    Background and aim: If a person does not become ambulant after an amputation, a knee disarticulation (KD) shouldbe considered and the person may then benefit from a cosmetic KD prosthesis. The features of a cosmetic KD prosthesis are, however, seldom described. The aim of this clinical note is to de

  9. 21 CFR 888.3730 - Toe joint phalangeal (hemi-toe) polymer prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Toe joint phalangeal (hemi-toe) polymer prosthesis. 888.3730 Section 888.3730 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... (hemi-toe) polymer prosthesis. (a) Identification. A toe joint phalangeal (hemi-toe) polymer...

  10. Biomedical and psychosocial factors influencing transtibial prosthesis fit : a Delphi survey among health care professionals

    NARCIS (Netherlands)

    Baars, Erwin C.; Schrier, Ernst; Geertzen, Jan H.; Dijkstra, Pieter U.

    2015-01-01

    Purpose: We aimed to reach consensus among professionals caring for prosthesis users, on definitions of biomedical and psychosocial factors, to assess their influence on fit of transtibial prosthesis and to identify new factors. Method: A three-round, internet-based, Delphi survey was conducted amon

  11. DEGRADATION OF A SUPPORTING PROSTHESIS CAN OPTIMIZE ARTERIALIZATION OF AUTOLOGOUS VEINS

    NARCIS (Netherlands)

    ZWEEP, HP; SATOH, S; VANDERLEI, B; HINRICHS, WLJ; FEIJEN, J; WILDEVUUR, CRH

    1993-01-01

    In a previous study, we implanted autologous vein grafts in the carotid artery of rabbits supported by a compliant, biodegradable prosthesis to prevent vein wall damage due to the higher arterial pressure. We showed that such a supporting prosthesis indeed reduces damage to these vein grafts and all

  12. Echocardiographic and phonocardiographic assessment of the St. Jude cardiac valve prosthesis.

    Science.gov (United States)

    DePace, N L; Kotler, M N; Mintz, G S; Lichtenberg, R; Goel, I P; Segal, B L

    1981-09-01

    Forty-three consecutive patients with a St. Jude mitral, aortic, or combined prosthesis were studied by simultaneous phonocardiography and echocardiography. Twenty-eight patients had a mitral prosthesis, 20 an aortic prosthesis, and five had both. No opening click was recorded in any patient; however, a loud aortic or mitral closing click was recorded in all 43 patients. In patients with St. Jude mitral valve prosthesis, an echo-free space separated the two leaflets during diastole; seven of these also had a mid-diastolic closing and late diastolic reopening motion; two of the seven had an associated closing mid-diastolic click. A mid-diastolic rumble was recorded in six of 28 patients with St. Jude mitral valve prosthesis. In patients with a St. Jude aortic valve prosthesis, left atrium leaflet motion was recorded in 17 of 20 patients and was indistinguishable in appearance from echocardiograms obtained with various eccentric monocusp valves. In addition, we report one case of malfunction of a St. Jude mitral valve and one case of a paravalvular leak diagnosed by echophonocardiography. We concluded that the St. Jude cardiac prosthesis has variable normal phonocardiographic-echocardiographic patterns. Knowledge of these variable patterns is important in assessing patients with suspected malfunction of a St. Jude cardiac prosthesis.

  13. 21 CFR 874.3540 - Prosthesis modification instrument for ossicular replacement surgery.

    Science.gov (United States)

    2010-04-01

    ... replacement surgery. 874.3540 Section 874.3540 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... § 874.3540 Prosthesis modification instrument for ossicular replacement surgery. (a) Identification. A prosthesis modification instrument for ossicular replacement surgery is a device intended for use by...

  14. A multichannel sEMG method for myoelectric control of a forearm prosthesis

    NARCIS (Netherlands)

    Baal, van D.W.; Witteveen, H.J.B.; Kallenberg, L.A.C.; Hermens, H.J.; Rietman, J.S.

    2009-01-01

    A large number of amputee patients doesn't use their myoelectric prosthesis, mainly due to the limited functionality of the prosthesis. The aim of this study was to investigate if it is possible to distinguish 8 different contractions by using multi-electrode sEMG. We analysed sEMG signals of a gri

  15. PARTIAL REPLACEMENT OF THE ESOPHAGEAL MUSCLE LAYERS BY A CARBON-FIBER PROSTHESIS

    NARCIS (Netherlands)

    RUKA, MP; TUNGEKAR, MF; KUIT, J; HOFSTRA, W

    1991-01-01

    In the present study we report on the surgical replacement of the thoracic portion of oesophageal muscularis by a synthetic carbon fibre (CF) prosthesis in a rabbit model. Our results, as corroborated by the oesophagograms and the post-operative weight gain, showed that this prosthesis functioned sa

  16. [Research on and design of visual prosthesis based on visual information processing].

    Science.gov (United States)

    Li, Sheng; Hu, Jie; Chai, Xinyu; Ren, Qiushi; Peng, Yinghong

    2012-08-01

    Induced by a variety of retinopathy, visual loss has become the most serious form of disability, which influences the quality of human life. With the rapid development and crossing among the information science, microelectronics, material science and biomedical disciplines, the visual prosthesis makes reparation possible for the visual blindness caused by retinitis pigmentosa, age-related macular degeneration, and other eye, retina, optic nerve and visual cortex lesions. With technology innovation, the prosthesis design, manufacturing and surgical technique are no longer the biggest obstacles to the future development of the visual prosthesis, but how to construct effective transmission of information between the brain and the prosthesis. However, due to the complex structure of the human visual system, the visual prosthesis manufacturing and visual information signal mapping are facing some difficulties. Thus, we can only study the representation strategy of image information and micro-electrode array stimulation basing on limited pixels of simulated prosthesis visual information. By studying the visual information processing of the visual prosthesis, we propose a visual prosthesis design which is based on biological, mechanical, and electronic integration.

  17. A Biomechanical Model for the Development of Myoelectric Hand Prosthesis Control Systems

    NARCIS (Netherlands)

    Peerdeman, Bart; Boere, Daphne; Kallenberg, Laura; Stramigioli, Stefano; Misra, Sarthak

    2010-01-01

    Advanced myoelectric hand prostheses aim to reproduce as much of the human hand's functionality as possible. Development of the control system of such a prosthesis is strongly connected to its mechanical design; the control system requires accurate information on the prosthesis' structure and the su

  18. Design, fabrication, and preliminary results of a novel below knee prosthesis for snowboarding: A case report

    NARCIS (Netherlands)

    Minnoye, A.L.M.; Plettenburg, D.H.

    2010-01-01

    Snowboarding with a below-knee prosthesis is compromised by the limited rotation capabilities of the existing below-knee prostheses, which are designed for use in normal walking. Based on snowboarding range of motion analyses, a novel below-knee prosthesis was designed with the aim to achieve simila

  19. Treatment of an old infection in a total hip replacement with an interim spacer prosthesis.

    Science.gov (United States)

    Zilkens, K W; Casser, H R; Ohnsorge, J

    1990-01-01

    When treating a septic hip-joint prosthesis with bone loss of the proximal femur secondary to osteomyelitis, we implanted a specially designed prosthesis to act as a local antibiotic and spacer between the acetabulum and femur until the infection abated. Arthroplasty could then be carried out with no trouble and there was no recurrence of infection.

  20. 21 CFR 888.3540 - Knee joint patellofemoral polymer/metal semi-constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Knee joint patellofemoral polymer/metal semi... § 888.3540 Knee joint patellofemoral polymer/metal semi-constrained cemented prosthesis. (a) Identification. A knee joint patellofemoral polymer/metal semi-constrained cemented prosthesis is a...

  1. 21 CFR 888.3550 - Knee joint patellofemorotibial polymer/metal/metal constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Knee joint patellofemorotibial polymer/metal/metal... § 888.3550 Knee joint patellofemorotibial polymer/metal/metal constrained cemented prosthesis. (a) Identification. A knee joint patellofemorotibial polymer/metal/metal constrained cemented prosthesis is a...

  2. 21 CFR 888.3590 - Knee joint tibial (hemi-knee) metallic resurfacing uncemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Knee joint tibial (hemi-knee) metallic resurfacing... Knee joint tibial (hemi-knee) metallic resurfacing uncemented prosthesis. (a) Identification. A knee joint tibial (hemi-knee) metallic resurfacing uncemented prosthesis is a device intended to be...

  3. 21 CFR 888.3520 - Knee joint femorotibial metal/polymer non-constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Knee joint femorotibial metal/polymer non... § 888.3520 Knee joint femorotibial metal/polymer non-constrained cemented prosthesis. (a) Identification. A knee joint femorotibial metal/polymer non-constrained cemented prosthesis is a device intended...

  4. 21 CFR 888.3500 - Knee joint femorotibial metal/composite semi-constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Knee joint femorotibial metal/composite semi... § 888.3500 Knee joint femorotibial metal/composite semi-constrained cemented prosthesis. (a) Identification. A knee joint femorotibial metal/composite semi-constrained cemented prosthesis is a...

  5. 21 CFR 888.3530 - Knee joint femorotibial metal/polymer semi-constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Knee joint femorotibial metal/polymer semi... § 888.3530 Knee joint femorotibial metal/polymer semi-constrained cemented prosthesis. (a) Identification. A knee joint femorotibial metal/polymer semi-constrained cemented prosthesis is a device...

  6. 21 CFR 888.3490 - Knee joint femorotibial metal/composite non-constrained cemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Knee joint femorotibial metal/composite non... § 888.3490 Knee joint femorotibial metal/composite non-constrained cemented prosthesis. (a) Identification. A knee joint femorotibial metal/composite non-constrained cemented prosthesis is a...

  7. 21 CFR 888.3565 - Knee joint patellofemorotibial metal/polymer porous-coated uncemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Knee joint patellofemorotibial metal/polymer... Devices § 888.3565 Knee joint patellofemorotibial metal/polymer porous-coated uncemented prosthesis. (a) Identification. A knee joint patellofemorotibial metal/polymer porous-coated uncemented prosthesis is a...

  8. 21 CFR 888.3580 - Knee joint patellar (hemi-knee) metallic resurfacing uncemented prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Knee joint patellar (hemi-knee) metallic... § 888.3580 Knee joint patellar (hemi-knee) metallic resurfacing uncemented prosthesis. (a) Identification. A knee joint patellar (hemi-knee) metallic resurfacing uncemented prosthesis is a device made...

  9. Ossiculoplasty with autologous incus versus titanium prosthesis: A comparison of anatomical and functional results

    Directory of Open Access Journals (Sweden)

    Amith I Naragund

    2011-01-01

    Full Text Available Aims: To analyze and compare the outcomes of ossiculoplasty in terms of hearing results and graft take-up rates, using autograft incus and titanium middle ear prosthesis in patients with ossicular chain erosion. Study Design: Randomized clinical trial. Materials and Methods: Patients between 10 and 60 years of age with a history of chronic ear discharge with moderate conductive deafness (>40 dB HL were included in the study. The patients underwent detailed ENT examination followed by audiological and radiological assessment of temporal bone and those patients with evidence of ossicular erosion were subjected to ossiculoplasty with autologous incus (group I or titanium prosthesis (group II randomly. The patients were followed up after 3 months to analyze the functional and anatomical results. Results: A total of 24 patients with ossicular chain defect were included in the study, of whom 12 patients underwent ossiculoplasty with autograft incus and 12 with titanium prosthesis. Postoperative hearing evaluation by pure tone audiogram was done after 3 months, which showed successful hearing improvement in 58% of cases with autologous incus as compared to 33% cases with titanium prosthesis. Complications and extrusion rate were also higher in patients with titanium prosthesis. Conclusion: Hearing results after ossiculoplasty with autologous incus were significantly better compared with those after titanium prosthesis. Also, complications and extrusion rate were higher in patients with titanium prosthesis. This indicates that ossiculoplasty with autoincus offers better hearing results with minimal complications and extrusion rates as compared to titanium prosthesis.

  10. A high-precision instrument for analyzing nonlinear dynamic behavior of bearing cage

    Science.gov (United States)

    Yang, Z.; Chen, H.; Yu, T.; Li, B.

    2016-08-01

    The high-precision ball bearing is fundamental to the performance of complex mechanical systems. As the speed increases, the cage behavior becomes a key factor in influencing the bearing performance, especially life and reliability. This paper develops a high-precision instrument for analyzing nonlinear dynamic behavior of the bearing cage. The trajectory of the rotational center and non-repetitive run-out (NRRO) of the cage are used to evaluate the instability of cage motion. This instrument applied an aerostatic spindle to support and spin test the bearing to decrease the influence of system error. Then, a high-speed camera is used to capture images when the bearing works at high speeds. A 3D trajectory tracking software tema Motion is used to track the spot which marked the cage surface. Finally, by developing the matlab program, a Lissajous' figure was used to evaluate the nonlinear dynamic behavior of the cage with different speeds. The trajectory of rotational center and NRRO of the cage with various speeds are analyzed. The results can be used to predict the initial failure and optimize cage structural parameters. In addition, the repeatability precision of instrument is also validated. In the future, the motorized spindle will be applied to increase testing speed and image processing algorithms will be developed to analyze the trajectory of the cage.

  11. Evaluation of cage micro-environment of mice housed on various types of bedding materials

    Science.gov (United States)

    Smith, E.; Stockwell, J.D.; Schweitzer, I.; Langley, S.H.; Smith, A.L.

    2004-01-01

    A variety of environmental factors can affect the outcomes of studies using laboratory rodents. One such factor is bedding. Several new bedding materials and processing methods have been introduced to the market in recent years, but there are few reports of their performance. In the studies reported here, we have assessed the cage micro-environment (in-cage ammonia levels, temperature, and humidity) of mice housed on various kinds of bedding and their combinations. We also compared results for bedding supplied as Nestpaks versus loose bedding. We studied C57BL/6J mice (commonly used) and NOD/LtJ mice (heavy soilers) that were maintained, except in one study, in static duplex cages. In general, we observed little effect of bedding type on in-cage temperature or humidity; however, there was considerable variation in ammonia concentrations. The lowest ammonia concentrations occurred in cages housing mice on hardwood bedding or a mixture of corncob and alpha cellulose. In one experiment comparing the micro-environments of NOD/LtJ male mice housed on woodpulp fiber bedding in static versus ventilated caging, we showed a statistically significant decrease in ammonia concentrations in ventilated cages. Therefore, our data show that bedding type affects the micro-environment in static cages and that effects may differ for ventilated cages, which are being used in vivaria with increasing frequency.

  12. A high-precision instrument for analyzing nonlinear dynamic behavior of bearing cage.

    Science.gov (United States)

    Yang, Z; Chen, H; Yu, T; Li, B

    2016-08-01

    The high-precision ball bearing is fundamental to the performance of complex mechanical systems. As the speed increases, the cage behavior becomes a key factor in influencing the bearing performance, especially life and reliability. This paper develops a high-precision instrument for analyzing nonlinear dynamic behavior of the bearing cage. The trajectory of the rotational center and non-repetitive run-out (NRRO) of the cage are used to evaluate the instability of cage motion. This instrument applied an aerostatic spindle to support and spin test the bearing to decrease the influence of system error. Then, a high-speed camera is used to capture images when the bearing works at high speeds. A 3D trajectory tracking software tema Motion is used to track the spot which marked the cage surface. Finally, by developing the matlab program, a Lissajous' figure was used to evaluate the nonlinear dynamic behavior of the cage with different speeds. The trajectory of rotational center and NRRO of the cage with various speeds are analyzed. The results can be used to predict the initial failure and optimize cage structural parameters. In addition, the repeatability precision of instrument is also validated. In the future, the motorized spindle will be applied to increase testing speed and image processing algorithms will be developed to analyze the trajectory of the cage.

  13. Stress Transfer Modeling at the Interface of Cemented Prosthesis and Femur

    Institute of Scientific and Technical Information of China (English)

    YU Xue-zhong; GUO Yi-mu; ZHANG Yun-qiu; LI Jun; HE Rong-xing

    2008-01-01

    .Objective:To model the stress transfer at the interface of the cemented prosthesis and femur, an axisymmetric model of the interfacial stress transfer was established.Methods: Assuming that the prosthesis, the cement and the femur were concentric cylinders with linear elastic and isotropic properties, distributions of the axial stresses in the prosthesis, the cement and the femur as well as the interfacial shear stresses at the prosthesis/cement interface and the cement/femur interface in the axial direction were obtained from the established axisymmetric stress transfer model.Results: Interfacial failure was the main form for the prosthesis/cement/femur structure under external loads. Considering the residual thermal stresses, it was more likely to produce the mixed failure form than the pure shear failure form. Since the cement had a relatively high thermal expansion coefficient, the thermal effect accelerated the interface failure and thus aggravated the stress shielding effect. Due to a relatively high thermal residual temperature difference, the interfacial debonding and femur failure was more likely to occur for the cobalt-chromium alloy prosthesis material than the Ti-6Al-4V alloy prosthesis material.Conclusion: Assuming that the prosthesis, the cement and the femur are concentric cylinders with linear elastic and isotropic properties, distributions of the axial stresses in the prosthesis, the cement and the femur as well as the interfacial shear stresses at the prosthesis/cement interface and the cement/femur interface in the axial direction was obtained using the basic equations of axisymmetric elastic mechanics when the prosthesis bears the compressive stresses. Interface failure is the main failure form for the prosthesis/cement/femur structure under external loads. The thermal effects accelerate the failure of the prosthesis/cement interface and the cement/femur interface and the relaxation of the prosthesis, and then aggravates the stress shielding

  14. An "Uncrimped" SMart Stapes Prosthesis: A Cause of Late Hearing Deterioration in Otosclerosis.

    Science.gov (United States)

    Randhawa, Premjit S; Hamilton, Nicholas; Narula, Antony A

    2012-01-01

    Statement of Problem. Stapedotomy is the treatment of choice for otosclerosis. Numerous techniques and prosthesis are available to perform this procedure. Success rates of surgery vary from 17% to 80%, and revision surgery carries an increased risk of complications as well as poorer hearing outcomes. Method of Study. Case report. Results. We report the first case of uncrimping of a SMart stapes prosthesis with no lateral displacement as a cause of late failure despite successful crimping and improvement in audiological outcomes after initial surgery. Conclusion. The SMart stapes prosthesis is widely used and has been shown to be safe and provide good hearing outcomes. Displacement of a stapes prosthesis is the commonest cause of failure. Our case shows that deterioration of hearing thresholds can occur from uncrimping of the prosthesis with no displacement. It is important to improve our understanding of stapedotomy failure as revision procedures are associated with poorer outcomes.

  15. An “Uncrimped” SMart Stapes Prosthesis: A Cause of Late Hearing Deterioration in Otosclerosis

    Science.gov (United States)

    Randhawa, Premjit S.; Hamilton, Nicholas; Narula, Antony A.

    2012-01-01

    Statement of Problem. Stapedotomy is the treatment of choice for otosclerosis. Numerous techniques and prosthesis are available to perform this procedure. Success rates of surgery vary from 17% to 80%, and revision surgery carries an increased risk of complications as well as poorer hearing outcomes. Method of Study. Case report. Results. We report the first case of uncrimping of a SMart stapes prosthesis with no lateral displacement as a cause of late failure despite successful crimping and improvement in audiological outcomes after initial surgery. Conclusion. The SMart stapes prosthesis is widely used and has been shown to be safe and provide good hearing outcomes. Displacement of a stapes prosthesis is the commonest cause of failure. Our case shows that deterioration of hearing thresholds can occur from uncrimping of the prosthesis with no displacement. It is important to improve our understanding of stapedotomy failure as revision procedures are associated with poorer outcomes. PMID:22431926

  16. Prosthesis infections after orthopedic joint replacement: the possible role of bacterial biofilms

    Directory of Open Access Journals (Sweden)

    Zhijun Song

    2013-06-01

    Full Text Available Prosthesis-related infection is a serious complication for patients after orthopedic joint replacement, which is currently difficult to treat with antibiotic therapy. Consequently, in most cases, removal of the infected prosthesis is the only solution to cure the infection. It is, therefore, important to understand the comprehensive interaction between the microbiological situation and the host immune responses that lead to prosthesis infections. Evidence indicates that prosthesis infections are actually biofilm-correlated infections that are highly resistant to antibiotic treatment and the host immune responses. The authors reviewed the related literature in the context of their clinical experience, and discussed the possible etiology and mechanism leading to the infections, especially problems related to bacterial biofilm, and prophylaxis and treatment of infection, including both microbiological and surgical measures. Recent progress in research into bacterial biofilm and possible future treatment options of prosthesis-related infections are discussed.

  17. An “Uncrimped” SMart Stapes Prosthesis: A Cause of Late Hearing Deterioration in Otosclerosis

    Directory of Open Access Journals (Sweden)

    Premjit S. Randhawa

    2012-01-01

    Full Text Available Statement of Problem. Stapedotomy is the treatment of choice for otosclerosis. Numerous techniques and prosthesis are available to perform this procedure. Success rates of surgery vary from 17% to 80%, and revision surgery carries an increased risk of complications as well as poorer hearing outcomes. Method of Study. Case report. Results. We report the first case of uncrimping of a SMart stapes prosthesis with no lateral displacement as a cause of late failure despite successful crimping and improvement in audiological outcomes after initial surgery. Conclusion. The SMart stapes prosthesis is widely used and has been shown to be safe and provide good hearing outcomes. Displacement of a stapes prosthesis is the commonest cause of failure. Our case shows that deterioration of hearing thresholds can occur from uncrimping of the prosthesis with no displacement. It is important to improve our understanding of stapedotomy failure as revision procedures are associated with poorer outcomes.

  18. Trabecular metal cup without augments for acetabular revision in case of extensive bone loss and low bone-prosthesis contact.

    Science.gov (United States)

    Pierannunzii, L; Mambretti, A; D'Imporzano, M

    2011-01-01

    Current evidences in revision hip arthroplasty suggest to treat severe acetabular bone loss with dedicated implants, such as anti-protrusio cages, stemmed cups, modular systems supplied with iliac flanges and obturatory hook. However recent literature is reporting satisfactory outcomes with simple elliptical Trabecular Metal cups. Purpose of the study was to evaluate mid-term results of such a surgical procedure. All hip revisions performed from 2008 to 2009 with implantation of a TMT multi-hole acetabular cup without augmentations were retrospectively reviewed. The cases with low-degree acetabular bone loss (stage I and II according to GIR classification), with surgical report poorly describing the bone defect, with inadequate pre- and post-operative x-rays were ruled out. Twenty-five cases were identified, but four were lost to follow-up. The twenty-one patients were 71 year-old on average (from 60 to 82), with stage IV bone loss in 6 cases and stage III bone loss in 15 cases. Mean interval from surgery to evaluation was 20.9 months (from 13 to 30). The evaluation included bone-prosthesis contact estimation, component position, survivorship, complications, final Harris Hip Score, presence of periprosthetic radiolucencies. Host bone-prosthesis contact was estimated to be about 35%. Only three implant were subsequently reoperated (for infection, early migration, recurrent dislocation). The HHS among non-reoperated 18 patients was 81.96 on average (from 63.44 to 95.82). Six cases showed thin radiolucencies in one of the three Charnley zones, while three cases showed radiolucencies in two. None of these images was evolutive, thus they were not considered signs of loosening. The mid-term results of this series confirm the hypothesis that a porous tantalum acetabular cup is an effective option to deal with difficult acetabular revisions. Although no extra-acetabular fixation device is available, the very high surface friction guaranteed by the material and the

  19. Frozen Autograft-Prosthesis Composite Reconstruction in Malignant Bone Tumors.

    Science.gov (United States)

    Subhadrabandhu, Saran; Takeuchi, Akihiko; Yamamoto, Norio; Shirai, Toshiharu; Nishida, Hideji; Hayashi, Katsuhiro; Miwa, Shinji; Tsuchiya, Hiroyuki

    2015-10-01

    Several methods are available using an endoprosthesis or biological reconstruction for malignant bone tumors. Methods that use allograft-prosthesis composites have shown promising results. In 1999, the authors developed a method of reconstruction that uses a tumor-bearing autograft treated with liquid nitrogen. This technique was modified to produce a pedicle frozen autograft to maintain anatomical continuity on one side. In this study, the results of bone reconstructions using frozen autograft-prosthesis composites were retrospectively evaluated. The demographic data, histological records, surgical procedures, functional scores, and complications of 22 patients who had bone sarcoma or metastasis and at least 2 years of follow-up were reviewed. There were 19 patients with primary bone sarcoma and 3 with bone metastasis. Average age was 36 years (range, 9-73 years), and mean follow-up was 63 months (range, 24-176 months). Reconstructions were performed on 10 proximal femurs, 5 distal femurs, 4 proximal tibias, 1 proximal humerus, 1 proximal radius, and 1 hemipelvis. There were 12 pedicle-freezing and 10 free-freezing procedures. Union rate was 90% (9/10), and average union time was 9.5 months. Average Musculoskeletal Tumor Society score was 89.3%. Complications included 1 fracture, 2 infections, 3 soft tissue recurrences, and 1 posterior interosseous nerve palsy. The authors concluded that the frozen autograft-prosthesis composite demonstrated excellent Musculoskeletal Tumor Society scores, a low complication rate, and a good union rate and was superior when used with the pedicle-freezing technique.

  20. Cervical disc prosthesis: 2-year follow-up

    Directory of Open Access Journals (Sweden)

    Romero Pinto de Oliveira Bilhar

    2015-06-01

    Full Text Available OBJECTIVE: To review the medical records of patients who underwent surgery for placement of cervical disc prosthesis after two years of postoperative follow-up, showing the basic epidemiological data, the technical aspects and the incidence of complications.METHODS: Medical records of seven patients who underwent surgery for placement of cervical disc prosthesis were reviewed after two years of follow-up, at the Institute of Orthopedics and Traumatology, Faculty of Medicine, University of São Paulo.RESULTS: The average age of patients participating in this study was 43.86 years. Six patients (85.7% had one level approached while one patient (14.3% had two levels addressed. The level C5-C6 has been approached in one patient (14.3% while the C6-C7 level was addressed in five patients (71.4%. One patient (14.3% had these two levels being addressed, C5-C6 and C6-C7. The mean operative time was 164.29±40 minutes. Three patients were hospitalized for 2 days and four for 3 days making an average of 2.57±0.535 days. Two patients (28.6% underwent a new surgical intervention due to loosening of the prosthesis. The mean follow-up was 28.14±5.178 months (23-35 months.CONCLUSIONS: Although cervical arthroplasty appears to be a safe procedure and present promising results in our study as well as in many other studies, it requires long-term studies.

  1. Design and preliminary testing of the RIC hybrid knee prosthesis.

    Science.gov (United States)

    Lenzi, T; Sensinger, J; Lipsey, J; Hargrove, L; Kuiken, T

    2015-08-01

    We present a novel hybrid knee prosthesis that uses a motor, transmission and control system only for active dynamics tasks, while relying on a spring/damper system for passive dynamics activities. Active dynamics tasks require higher torque, lower speed, and occur less frequently than passive dynamic activities. By designing the actuation system around active tasks alone, we achieved a lightweight design (1.7 Kg w/o battery) without sacrificing peak torque (85Nm repetitive). Preliminary tests performed by an able-bodied person using a bypass orthosis show that the hybrid knee can support reciprocal stairs ambulation with low electrical energy consumption.

  2. Definitive magnetic nasal prosthesis for partial nasal defect

    Directory of Open Access Journals (Sweden)

    E Nagaraj

    2011-01-01

    Full Text Available Maxillofacial trauma refers to any injury to the face or jaw caused by physical force, trauma, the presence of foreign objects, animal or human bites, and burns. Facial defects can be devastating in their impact on physical structure and function of the affected individual, leading to potential compromises in quality of life. Restoration of facial defects, especially nasal defects, is a difficult challenge for both the surgeon and the prosthodontist. Here is a case report of partial nasal defect caused by trauma, rehabilitated with a magnetic nasal prosthesis made with silicone elastomers using mechanical and anatomical retentive aids.

  3. Amputation and prosthesis implantation shape body and peripersonal space representations

    OpenAIRE

    2013-01-01

    Little is known about whether and how multimodal representations of the body (BRs) and of the space around the body (Peripersonal Space, PPS) adapt to amputation and prosthesis implantation. In order to investigate this issue, we tested BR in a group of upper limb amputees by means of a tactile distance perception task and PPS by means of an audio-tactile interaction task. Subjects performed the tasks with stimulation either on the healthy limb or the stump of the amputated limb, while wearin...

  4. Rupture of an expander prosthesis mimics axillary cancer recurrence.

    LENUS (Irish Health Repository)

    Ismael, T

    2005-10-01

    Regional silicone gel migration from a ruptured breast implant has been reported at different locations including the upper extremity, chest wall muscles, axilla and back. We report a patient who presented with an axillary mass that mimicked a regional recurrence 5 years after breast cancer reconstruction with a latissimus dorsi musculocutaneous flap and silicon gel expander-prosthesis. Surgical exploration revealed that the mass contained silicone gel around the port of the breast expander that had ruptured. The mass was confluent with an intracapsular silicone leak through a tract along the tube of the expander port.

  5. Abnormal behavior in caged birds kept as pets.

    Science.gov (United States)

    van Hoek, C S; ten Cate, C

    1998-01-01

    There are a limited number of studies dealing with abnormal behavior in caged birds kept as pets. However, these studies demonstrate the presence of abnormal behavior in both songbirds and parrots. Ethological studies on these birds, as well as studies on domestic and zoo birds, indicate that inappropriate rearing and housing conditions may lead to behavioral abnormalities. Together these data indicate that behavioral abnormalities occur among both wild-caught and domesticated pet birds. The severity and magnitude of these abnormalities is probably underestimated, and there is a need for systematic studies on the nature, origin, variability, species-specificity, and reversibility of behavioral problems in pet birds. Abnormal behavior in caged birds may to some extent be prevented and reduced by environmental enrichment. However, most enrichment studies are anecdotal and not based on a thorough analysis of the behavioral abnormalities, which may lead to measures resulting in a reduction of symptoms rather than the underlying causes. Although it is likely that several of these problems could be reduced by modifying rearing and housing conditions, the current insights into the causal mechanisms underlying abnormal behavior of domesticated and wild-caught pet birds are limited, as are the insights into the possibilities of preventing or curing abnormal behavior.

  6. Protection characteristics of a Faraday cage compromised by lightning burnthrough.

    Energy Technology Data Exchange (ETDEWEB)

    Warne, Larry Kevin; Bystrom, Edward; Jorgenson, Roy Eberhardt; Montoya, Sandra L.; Merewether, Kimball O.; Coats, Rebecca Sue; Martinez, Leonard E.; Jojola, John M.

    2012-01-01

    A lightning flash consists of multiple, high-amplitude but short duration return strokes. Between the return strokes is a lower amplitude, continuing current which flows for longer duration. If the walls of a Faraday cage are made of thin enough metal, the continuing current can melt a hole through the metal in a process called burnthrough. A subsequent return stroke can couple energy through this newly-formed hole. This LDRD is a study of the protection provided by a Faraday cage when it has been compromised by burnthrough. We initially repeated some previous experiments and expanded on them in terms of scope and diagnostics to form a knowledge baseline of the coupling phenomena. We then used a combination of experiment, analysis and numerical modeling to study four coupling mechanisms: indirect electric field coupling, indirect magnetic field coupling, conduction through plasma and breakdown through the hole. We discovered voltages higher than those encountered in the previous set of experiments (on the order of several hundreds of volts).

  7. Construction of silica-enhanced S-layer protein cages.

    Science.gov (United States)

    Schuster, D; Küpcü, S; Belton, D J; Perry, C C; Stöger-Pollach, M; Sleytr, U B; Pum, D

    2013-03-01

    The work presented here shows for the first time that it is possible to silicify S-layer coated liposomes and to obtain stable functionalized hollow nano-containers. For this purpose, the S-layer protein of Geobacillus stearothermophilus PV72/p2 was recombinantly expressed and used for coating positively charged liposomes composed of dipalmitoylphosphatidylcholine, cholesterol and hexadecylamine in a molar ratio of 10:5:4. Subsequently, plain (uncoated) liposomes and S-layer coated liposomes were silicified. Determination of the charge of the constructs during silicification allowed the deposition process to be followed. After the particles had been silicified, lipids were dissolved by treatment with Triton X-100 with the release of previously entrapped fluorescent dyes being determined by fluorimetry. Both, ζ-potential and release experiments showed differences between silicified plain liposomes and silicified S-layer coated liposomes. The results of the individual preparation steps were examined by embedding the respective assemblies in resin, ultrathin sectioning and inspection by bright-field transmission electron microscopy (TEM). Energy filtered TEM confirmed the successful construction of S-layer based silica cages. It is anticipated that this approach will provide a key to enabling technology for the fabrication of nanoporous protein cages for applications ranging from nano medicine to materials science.

  8. Automated Operant Conditioning in the Mouse Home Cage

    Science.gov (United States)

    Francis, Nikolas A.; Kanold, Patrick O.

    2017-01-01

    Recent advances in neuroimaging and genetics have made mice an advantageous animal model for studying the neurophysiology of sensation, cognition, and locomotion. A key benefit of mice is that they provide a large population of test subjects for behavioral screening. Reflex-based assays of hearing in mice, such as the widely used acoustic startle response, are less accurate than operant conditioning in measuring auditory processing. To date, however, there are few cost-effective options for scalable operant conditioning systems. Here, we describe a new system for automated operant conditioning, the Psibox. It is assembled from low cost parts, designed to fit within typical commercial wire-top cages, and allows large numbers of mice to train independently in their home cages on positive reinforcement tasks. We found that groups of mice trained together learned to accurately detect sounds within 2 weeks of training. In addition, individual mice isolated from groups also showed good task performance. The Psibox facilitates high-throughput testing of sensory, motor, and cognitive skills in mice, and provides a readily available animal population for studies ranging from experience-dependent neural plasticity to rodent models of mental disorders. PMID:28298887

  9. Electromechanical interaction in rotordynamics of cage induction motors

    Science.gov (United States)

    Holopainen, Timo P.; Tenhunen, Asmo; Arkkio, Antero

    2005-06-01

    Eccentric rotor motion induces an unbalanced magnetic pull between the rotor and stator of cage induction motors. Recently, a linear parametric model of this eccentricity force due to the arbitrary rotor motion was presented. The purpose of this study is to combine this electromagnetic force model with a simple mechanical rotor model, and further, to demonstrate the rotordynamic response induced by this electromechanical interaction. An electromechanical rotor model is derived on the basis of the Jeffcott rotor with two additional variables for the harmonic currents of the rotor cage. Applying this model, the rotordynamic effects of electromechanical interaction were studied. Three induction motors were used in the numerical examples. The electromechanical parameters of these motors were estimated from the numerical simulations carried out separately. The results obtained show that the electromechanical interaction may decrease the natural frequencies of the rotor, induce additional damping or cause rotordynamic instability. These interaction effects are most significant in motors operating at or near the first bending critical speed. Excluding the potential rotordynamic instability, the numerical results indicate that the electromechanical interaction reduces effectively the unbalance response close to the first bending critical speed.

  10. Assessment of Lower Limb Prosthesis through Wearable Sensors and Thermography

    Science.gov (United States)

    Cutti, Andrea Giovanni; Perego, Paolo; Fusca, Marcello C.; Sacchetti, Rinaldo; Andreoni, Giuseppe

    2014-01-01

    This study aimed to explore the application of infrared thermography in combination with ambulatory wearable monitoring of temperature and relative humidity, to assess the residual limb-to-liner interface in lower-limb prosthesis users. Five male traumatic transtibial amputees were involved, who reported no problems or discomfort while wearing the prosthesis. A thermal imaging camera was used to measure superficial thermal distribution maps of the stump. A wearable system for recording the temperature and relative humidity in up to four anatomical points was developed, tested in vitro and integrated with the measurement set. The parallel application of an infrared camera and wearable sensors provided complementary information. Four main Regions of Interest were identified on the stump (inferior patella, lateral/medial epicondyles, tibial tuberosity), with good inter-subject repeatability. An average increase of 20% in hot areas (P < 0.05) is shown after walking compared to resting conditions. The sensors inside the cuff did not provoke any discomfort during recordings and provide an inside of the thermal exchanges while walking and recording the temperature increase (a regime value is ∼+1.1 ± 0.7 °C) and a more significant one (∼+4.1 ± 2.3%) in humidity because of the sweat produced. This study has also begun the development of a reference data set for optimal socket/liner-stump construction. PMID:24618782

  11. Prosthesis intolerance in patients with transfemoral amputation: a videocapillaroscopic study.

    Science.gov (United States)

    Macchi, Claudio; Cassigoli, Silvia; Lova, Raffaele Molino; Roccuzzo, Aurelio; Miniati, Benedetta; Ceppatelli, Simone; Conti, Andrea A; Gensini, Gian Franco

    2004-06-01

    Videocapillaroscopy is a new technique allowing a noninvasive examination of the capillary framework of the skin by using a contact probe with magnifying lenses and a cold-light epiluminescence system. The aim of this article was to investigate, by videocapillaroscopy, the microcirculation of the skin of the stump in 70 consecutive patients with unilateral transfemoral amputation. Patients were divided into two subgroups according to their tolerance (A) or intolerance (B) to a prosthesis with an Icelandic-Swedish-New York socket. Subgroup A included 48 patients, 17 diabetic and 31 nondiabetic, and subgroup B included 22 patients, 16 diabetic and 6 nondiabetic. In subgroup B, the caliber of capillary loops was significantly larger (mean +/-standard deviation, 23.6 +/-2.04 vs. 16.2 +/-1.96 microm; P < 0.001), neoangiogenesis was significantly more frequent (82%vs. 25%, P < 0.001), and the presence of microaneurysms (64%vs. 15%, P < 0.001) and microhemorrhages (36%vs. 4%, P < 0.001) was also more frequent. Surprisingly, some such diabetes-like microvascular changes were also found in the six nondiabetic patients of subgroup B. By using multiple logistic regression analysis, intolerance to the prosthesis was significantly related to microvascular changes (P = 0.001) but not to diabetes (P = 0.601), although diabetes was unequally distributed in the two subgroups.

  12. Simultaneous penile prosthesis and male sling/artificial urinary sphincter

    Institute of Scientific and Technical Information of China (English)

    Dominic Lee; Claudio Romero; Frances Alba; O Lenaine Westney; Run Wang

    2013-01-01

    Erectile dysfunction (ED) and stress urinary incontinence (SUI) from urethral sphincteric deficiency is not an uncommon problem.The commonest etiology is intervention for localized prostate cancer and/or radical cystoprostatectomy for muscle invasive bladder cancer.Despite advances in surgical technology with robotic assisted laparoscopic prostatectomy and nerve sparingtechniques,the rates of ED and SUI remain relatively unchanged.They both impact greatly on quality of life domains and have been associated with poor performance outcomes.Both the artificial urinary sphincter and penile prosthesis are gold standard treatments with proven efficacy,satisfaction and durability for end-stage SUI and ED respectively.Simultaneous prosthesis implantation for concurrent conditions has been well described,mostly in small retrospective series.The uptake of combination surgery has been slow due in part to technical demands of the surgery and to an extent,a heightened anxiety over potential complications.This paper aims to discuss the technical aspect of concurrent surgery for both disease entity and the current published outcomes of the various surgical techniques with this approach.

  13. Assessment of Lower Limb Prosthesis through Wearable Sensors and Thermography

    Directory of Open Access Journals (Sweden)

    Andrea Giovanni Cutti

    2014-03-01

    Full Text Available This study aimed to explore the application of infrared thermography in combination with ambulatory wearable monitoring of temperature and relative humidity, to assess the residual limb-to-liner interface in lower-limb prosthesis users. Five male traumatic transtibial amputees were involved, who reported no problems or discomfort while wearing the prosthesis. A thermal imaging camera was used to measure superficial thermal distribution maps of the stump. A wearable system for recording the temperature and relative humidity in up to four anatomical points was developed, tested in vitro and integrated with the measurement set. The parallel application of an infrared camera and wearable sensors provided complementary information. Four main Regions of Interest were identified on the stump (inferior patella, lateral/medial epicondyles, tibial tuberosity, with good inter-subject repeatability. An average increase of 20% in hot areas (P < 0.05 is shown after walking compared to resting conditions. The sensors inside the cuff did not provoke any discomfort during recordings and provide an inside of the thermal exchanges while walking and recording the temperature increase (a regime value is ~+1.1 ± 0.7 °C and a more significant one (~+4.1 ± 2.3% in humidity because of the sweat produced. This study has also begun the development of a reference data set for optimal socket/liner-stump construction.

  14. Design of a biomimetic polymer-composite hip prosthesis.

    Science.gov (United States)

    Bougherara, Habiba; Bureau, Martin; Campbell, Melissa; Vadean, Aurelian; Yahia, L'Hocine

    2007-07-01

    A new biomimetic composite hip prosthesis (stem) was designed to obtain properties similar to those of the contiguous bone, in particular stiffness, to allow normal loading of the surrounding femoral bone. This normal loading would reduce excessive stress shielding, known to result in bone loss, and micromotions at the bone-implant interface, leading to aseptic prosthetic loosening. The design proposed is based on a hollow substructure made of hydroxyapatite-coated, continuous carbon fiber (CF) reinforced polyamide 12 (PA12) composite with an internal soft polymer-based core. Different composite configurations were studied to match the properties of host tissue. Nonlinear three-dimensional analysis of the hip prosthesis was carried out using a three-dimensional finite element bone model based on the composite femur. The performance of composite-based hip and titanium alloy-based (Ti-6Al-4V) stems embedded into femoral bone was compared. The effect of core stiffness and ply configuration was also analyzed. Results show that stresses in composite stem are lower than those in Ti stem, and that the femoral bone implanted with composite structure sustains more load than the one implanted with Ti stem. Micromotions in the composite stem are significantly smaller than those in Ti stem over the entire bone-implant surface because of the favorable interfacial stress distribution.

  15. Development of an implantable myoelectric sensor for advanced prosthesis control.

    Science.gov (United States)

    Merrill, Daniel R; Lockhart, Joseph; Troyk, Phil R; Weir, Richard F; Hankin, David L

    2011-03-01

    Modern hand and wrist prostheses afford a high level of mechanical sophistication, but the ability to control them in an intuitive and repeatable manner lags. Commercially available systems using surface electromyographic (EMG) or myoelectric control can supply at best two degrees of freedom (DOF), most often sequentially controlled. This limitation is partially due to the nature of surface-recorded EMG, for which the signal contains components from multiple muscle sources. We report here on the development of an implantable myoelectric sensor using EMG sensors that can be chronically implanted into an amputee's residual muscles. Because sensing occurs at the source of muscle contraction, a single principal component of EMG is detected by each sensor, corresponding to intent to move a particular effector. This system can potentially provide independent signal sources for control of individual effectors within a limb prosthesis. The use of implanted devices supports inter-day signal repeatability. We report on efforts in preparation for human clinical trials, including animal testing, and a first-in-human proof of principle demonstration where the subject was able to intuitively and simultaneously control two DOF in a hand and wrist prosthesis.

  16. Cosmetic effect of knee joint in a knee disarticulation prosthesis

    Directory of Open Access Journals (Sweden)

    Fred A. de Laat, MD, PhD

    2015-03-01

    Full Text Available Despite numerous advantages, knee disarticulations (KDs are rarely performed because of the anticipated KD prosthesis fitting problems that include the positioning of the knee joint distally from the KD socket. This results in lengthening of the thigh and subsequent shortening of the shank. The objective of this study was to assess the cosmetic effect of the knee joint in a KD prosthesis by determining the extent of the lengthening of the thigh and the shortening of the shank. This lengthening and shortening were measured through an experimental setup using laser techniques. These measurements were made of 18 knee joints used in KD prostheses. Lengthening of the thigh varied between 23 and 92 mm, and shortening of the shank varied between 3 and 50 mm. The polycentric knees Medi KH6 and Medi KHF1 showed the least lengthening of the thigh, and the polycentric knees Teh Lin Prosthetic & Orthotic Co. Ltd Graph-Lite and Medi KP5 showed the least shortening of the shank.

  17. Proximal femur reconstruction by an allograft prosthesis composite.

    Science.gov (United States)

    Donati, Davide; Giacomini, Stefano; Gozzi, Enrico; Mercuri, Mario

    2002-01-01

    Twenty-seven patients who had resection of the proximal femur for bone tumors and reconstruction with an allograft prosthesis composite are reported. In most of the patients, the prosthesis was a long-stem revision type, cemented in the allograft and uncemented in the femoral shaft. The abductor muscles and iliopsoas were sutured to the corresponding tendons on the allograft. Implant-related complications and functional results were evaluated and are reported. Twenty-two patients achieved a minimum followup of 36 months (range, 36-126 months; average, 58 months). The implant was removed in two patients (one for infection, one for intraoperative fracture of the allograft). One patient experienced nonunion, whereas in the remaining 24 patients, the allograft eventually united to the host bone. A frequent late complication (17 patients) was fracture of the greater trochanter of the allograft. In the whole series, only four new operations were done for implant-related complications. In 22 patients who could be evaluated, the functional evaluation according to the Musculoskeletal Tumor Society System was excellent in 16 (73%) patients, good in four (18%), and fair in two (9%). These results compare favorably with those of megaprostheses for tumor resection of the proximal femur, where a Trendelenburg gait almost always is present.

  18. Development of an integrated CAD-FEA system for patient-specific design of spinal cages.

    Science.gov (United States)

    Zhang, Mingzheng; Pu, Fang; Xu, Liqiang; Zhang, Linlin; Liang, Hang; Li, Deyu; Wang, Yu; Fan, Yubo

    2017-03-01

    Spinal cages are used to create a suitable mechanical environment for interbody fusion in cases of degenerative spinal instability. Due to individual variations in bone structures and pathological conditions, patient-specific cages can provide optimal biomechanical conditions for fusion, strengthening patient recovery. Finite element analysis (FEA) is a valuable tool in the biomechanical evaluation of patient-specific cage designs, but the time- and labor-intensive process of modeling limits its clinical application. In an effort to facilitate the design and analysis of patient-specific spinal cages, an integrated CAD-FEA system (CASCaDeS, comprehensive analytical spinal cage design system) was developed. This system produces a biomechanical-based patient-specific design of spinal cages and is capable of rapid implementation of finite element modeling. By comparison with commercial software, this system was validated and proven to be both accurate and efficient. CASCaDeS can be used to design patient-specific cages with a superior biomechanical performance to commercial spinal cages.

  19. Standard methods for maintaining adult Apis mellifera in cages under in vitro laboratory conditions

    NARCIS (Netherlands)

    Williams, G.R.; Alaux, C.; Costa, C.; Csaki, C.; Steen, van der J.J.M.

    2013-01-01

    Adult honey bees are maintained in vitro in laboratory cages for a variety of purposes. For example, researchers may wish to perform experiments on honey bees caged individually or in groups to study aspects of parasitology, toxicology, or physiology under highly controlled conditions, or they may c

  20. Mercury accumulation in caged Corbicula: rate of uptake and seasonal variation.

    Science.gov (United States)

    Neufeld, Douglas S G

    2010-09-01

    The uptake and seasonal fluctuations of total mercury were followed in caged and uncaged Asiatic clams, Corbicula fluminea, over a 1-year period in South River, Virginia. Mercury was rapidly accumulated in clams transplanted from a nominally uncontaminated site into cages on the contaminated South River, reaching 0.99 microg g(-1) dry mass within the first month. Resident clams moved to cages had higher mercury contents after the first month (2.04 microg g(-1) dry mass) and at all subsequent times in the study. Large monthly fluctuations in mercury were noted for both resident caged and transplant caged clams with a notable peak occurring in early spring (4.31 microg g(-1) dry mass in resident caged clams). Tissue mass of caged clams steadily increased through the winter and early spring. Adjustment of mercury concentrations for tissue mass changes indicated that the changes in mercury contents were primarily due to uptake/release rather than changes in tissue mass (concentration/dilution). The present study demonstrates the utility of using caged Corbicula as mercury biomonitors and illustrates the importance of accounting for large, short-term changes of mercury content in Corbicula when designing long-term biomonitoring studies.

  1. International standardization of cage designs and feeding regimes for honey bee in vitro experiments

    Science.gov (United States)

    The aim of this study was to improve and standardize cage systems for maintaining adult honey bee workers under in vitro laboratory conditions. To achieve this goal, we experimentally evaluated the impact of different cages, developed by scientists of the international research network COLOSS (Preve...

  2. A generic strategy for pharmacological caging of growth factors for tissue engineering.

    Science.gov (United States)

    Karlsson, Maria; Lienemann, Philipp S; Sprossmann, Natallia; Heilmann, Katharina; Brummer, Tilman; Lutolf, Matthias P; Ehrbar, Martin; Weber, Wilfried

    2013-07-01

    The caging of small molecules has revolutionized biological research by providing a means to regulate a wide range of processes. Here we report on a generic pharmacological method to cage proteins in a similar fashion. The present approach is of value in both fundamental and applied research, e.g. in tissue engineering.

  3. A pyrrolo-tetrathiafulvalene cage: Synthesis and X-ray crystal structure

    DEFF Research Database (Denmark)

    Nielsen, Kent A.; Jeppesen, Jan O.; Levillain, Eric;

    2002-01-01

    A novel type of tetrathiafulvalene-cage 4 containing three monopyrrolo-tetrathiafulvalene units has been prepared employing a general and efficient synthetic approach. X-ray crystal structure analysis revealed that the cage is able to accommodate solvent molecules within a cavity in the solid state....

  4. Improving aeration for efficient oxygenation in sea bass sea cages. Blood, brain and gill histology

    Directory of Open Access Journals (Sweden)

    Berillis Panagiotis

    2016-01-01

    Full Text Available An air diffusion based system (Airx was developed to control the dissolved oxygen levels in aquaculture sea cages. The system was introduced and then tested for 37 days in a sea bass sea cage (aerated cage. A second sea bass sea cage, without the AirX, was used as a control. Oxygen levels were measured in both cages at the start of the trial, before the AirX system was introduced, and during the working period of the AirX system. Fish samples were collected 15 days after the AirX system was introduced and at the end of the experiment. Blood smears were prepared and examined microscopically. Erythrocyte major axis, minor axis and area of fish erythrocytes were measured. Leucocyte differentiation was also examined. In the control cage, the fish had significantly larger red blood cells when compared with the red blood cells of the fish in the aerated cage. Histological examination of the gills and brain revealed no morphological differences or alterations between the two groups of fish. This study demonstrated that an air diffuser system could improve the water quality of fish farmed in sea cages and enhance sea bass physiological performance, especially if DO levels fall below 60% oxygen saturation.

  5. Timing of DVT prophylaxis and risk of postoperative knee prosthesis infection.

    Science.gov (United States)

    Asensio, Angel; Antolín, Francisco J; Sanchez-García, Joseph M; Hidalgo, Olga; Hernández-Navarrete, Maria Jesús; Bishopberger, Cornelia; Miguel, Lucía García-San; Gay-Pobes, Andrés; Cabrera-Quintero, Alberto; Asensio, Paula; Sanz-Sebastián, Cristina; Gonzalez-Torga, Antonio; Ortiz-Espada, Alejandro; Pérez-Serrano, Luis; Ramos, Antonio

    2010-11-02

    This multicenter prospective study was performed to determine risk factors for knee prosthesis infection and the effect of timing doses of prophylactic low-molecular-weight heparins (LMWH) related to time of surgery on the risk of knee prosthesis infection. A total of 5496 consecutive patients who underwent total knee arthroplasty from 2005 to 2006 in 13 orthopedic centers were prospectively followed up for 6 months, and the incidence of knee prosthesis infection was recorded. A case control study was nested in the cohort. Case patients were matched to uninfected (control) patients, and the timing of perioperative LMWH was recorded as the main risk factor. Fifty patients developed postoperative knee prosthesis infection during the follow-up period, yielding an incidence of prosthesis infection of 0.91% (95% CI, 0.68%-1.20%). Forty-four patients were matched to 106 controls. Case patients received the first LMWH dose ±12 hours from the start of surgery more frequently than their control counterparts (odds ratio, 1.5; 95% CI, 0.73-3.0). After adjusting by main risk factors, no statistical association was found between close perioperative timing of LMWH and risk of prosthesis infection. Diabetes mellitus (adjusted odds ratio, 3.2; 95% CI, 1.2-8.8) and wound hematoma (adjusted odds ratio, 4.2; 95% CI, 1.1-16.5) were found to be independent risk factors for prosthesis infection.

  6. Parameters estimation of squirrel-cage induction motors using ANN and ANFIS

    Directory of Open Access Journals (Sweden)

    Mehdi Ahmadi Jirdehi

    2016-03-01

    Full Text Available In the transient behavior analysis of a squirrel-cage induction motor, the parameters of the single-cage and double-cage models are studied. These parameters are usually hard to obtain. This paper presents two new methods to predict the induction motor parameters in the single-cage and double-cage models based on artificial neural network (ANN and adaptive neuro-fuzzy inference system (ANFIS. For this purpose, the experimental data (manufacturer data of 20 induction motors with the different power are used. The experimental data are including of the starting torque and current, maximum torque, full load sleep, efficiency, rated active power and reactive power. The obtained results from the proposed ANN and ANFIS models are compared with each other and with the experimental data, which show a good agreement between the predicted values and the experimental data. But the proposed ANFIS model is more accurate than the proposed ANN model.

  7. Dynamic Analysis of Flexible Cage of High-speed Angular Contact Ball Bearing

    Institute of Scientific and Technical Information of China (English)

    邓四二; 谢鹏飞; 杨海生; 高银涛

    2012-01-01

    A dynamics formula was established for the flexible cage of high-speed angular contact ball bearing. A modified Craig-Bampton component mode synthetic method was used to establish the formula with regard to the flexibility of cage and based on a dynamic analysis of angular contact ball bearing, and a rigid-flexible multi-body dynamic analysis program was developed using ADAMS, which is verified by a computation example of Gupta. The results show that it' s not likely to keep the rotation smoothness of cage when the ratio of pocket clearance to guiding clearance and the ratio of radial load to axial load become too large or too small. By comparison, the flexible cage runs more smoothly than the rigid cage.

  8. Magnetotactic Bacterial Cages as Safe and Smart Gene Delivery Vehicles

    KAUST Repository

    Alsaiari, Shahad K.

    2016-07-27

    In spite of the huge advances in the area of synthetic carriers, their efficiency still poorly compares to natural vectors. Herein, we report the use of unmodified magnetotactic bacteria as a guidable delivery vehicle for DNA functionalized gold nanoparticles (AuNPs). High cargo loading is established under anaerobic conditions (bacteria is alive) through endocytosis where AuNPs are employed as transmembrane proteins mimics (facilitate endocytosis) as well as imaging agents to verify and quantify loading and release. The naturally bio-mineralized magnetosomes, within the bacteria, induce heat generation inside bacteria through magnetic hyperthermia. Most importantly after exposing the system to air (bacteria is dead) the cell wall stays intact providing an efficient bacterial vessel. Upon incubation with THP-1 cells, the magnetotactic bacterial cages (MBCs) adhere to the cell wall and are directly engulfed through the phagocytic activity of these cells. Applying magnetic hyperthermia leads to the dissociation of the bacterial microcarrier and eventual release of cargo.

  9. Classical Effective Field Theory and Caged Black Holes

    CERN Document Server

    Kol, Barak

    2007-01-01

    Matched Asymptotic Expansion (MAE) is a useful technique in General Relativity and other fields whenever interaction takes place between physics at two different length scales. Here MAE is argued to be equivalent quite generally to Classical Effective Field Theory (ClEFT) where one (or more) of the zones is replaced by an effective theory whose terms are organized in order of increasing irrelevancy, as demonstrated by Goldberger and Rothstein in a certain gravitational context. The ClEFT perspective has advantages as the procedure is clearer, it allows a representation via Feynman diagrams, and divergences can be regularized and renormalized in standard field theoretic methods. As a side product we obtain a wide class of classical examples of regularization and renormalization, concepts which are usually associated with Quantum Field Theories. We demonstrate these ideas through the thermodynamics of caged black holes, both simplifying the non-rotating case, and computing the rotating case. In particular we ar...

  10. Resonance Spectra of Caged Stringy Black Hole and Its Spectroscopy

    CERN Document Server

    Sakalli, I

    2015-01-01

    The Maggiore's method (MM), which evaluates the transition frequency that appears in the adiabatic invariant from the highly damped quasinormal mode (QNM) frequencies, is used to investigate the entropy/area spectra of the Garfinkle--Horowitz--Strominger black hole (GHSBH). Instead of the ordinary QNMs, we compute the boxed QNMs (BQNMs) that are the characteristic resonance spectra of the confined scalar fields in the GHSBH geometry. For this purpose, we assume that the GHSBH has a confining cavity (mirror) placed in the vicinity of the event horizon. We then show how the complex resonant frequencies of the caged GHSBH are computed using the Bessel differential equation that arises when the scalar perturbations around the event horizon are considered. Although the entropy/area is characterized by the GHSBH parameters, their quantization is shown to be independent of those parameters. However, both spectra are equally spaced.

  11. Resonance Spectra of Caged Stringy Black Hole and Its Spectroscopy

    Directory of Open Access Journals (Sweden)

    I. Sakalli

    2015-01-01

    quasinormal mode (QNM frequencies, is used to investigate the entropy/area spectra of the Garfinkle–Horowitz–Strominger black hole (GHSBH. Instead of the ordinary QNMs, we compute the boxed QNMs (BQNMs that are the characteristic resonance spectra of the confined scalar fields in the GHSBH geometry. For this purpose, we assume that the GHSBH has a confining cavity (mirror placed in the vicinity of the event horizon. We then show how the complex resonant frequencies of the caged GHSBH are computed using the Bessel differential equation that arises when the scalar perturbations around the event horizon are considered. Although the entropy/area is characterized by the GHSBH parameters, their quantization is shown to be independent of those parameters. However, both spectra are equally spaced.

  12. Chemistry and biology of the caged Garcinia xanthones.

    Science.gov (United States)

    Chantarasriwong, Oraphin; Batova, Ayse; Chavasiri, Warinthorn; Theodorakis, Emmanuel A

    2010-09-03

    Natural products have been a great source of many small molecule drugs for various diseases. In spite of recent advances in biochemical engineering and fermentation technologies that allow us to explore microorganisms and the marine environment as alternative sources of drugs, more than 70 % of the current small molecule therapeutics derive their structures from plants used in traditional medicine. Natural-product-based drug discovery relies heavily on advances made in the sciences of biology and chemistry. Whereas biology aims to investigate the mode of action of a natural product, chemistry aims to overcome challenges related to its supply, bioactivity, and target selectivity. This review summarizes the explorations of the caged Garcinia xanthones, a family of plant metabolites that possess a unique chemical structure, potent bioactivities, and a promising pharmacology for drug design and development.

  13. CAGE Analysis of China’s Trade Globalization

    Directory of Open Access Journals (Sweden)

    Emmanuel Olusegun STOBER

    2014-06-01

    Full Text Available Gravity model of international trade states that trade interaction between two countries is in direct proportion to their size measured by Gross Domestic Product and in inverse proportion to the geographic distance. Conley and Ligon (2001 argued that the relevant economic distance between countries is often not the geographic distance. Thus, this study uses original datasets on economic distance to structure observed variations, to decompose the multidimensional CAGE distance framework of globalization derived from the Newton’s Law of gravitation as it applies to China’s international interaction, to evaluate bilateral trade patterns in identifying and prioritizing the importance of cross-border flows and differences that accounted for the development of China’s global strategies. This study confirms that distance must be accounted for in the decision making of any country’s globalization process or any firm’s global expansion as the effects on cross-border economic activities are enormous.

  14. Cage Versus Noncage Laying-Hen Housings: Respiratory Exposures.

    Science.gov (United States)

    Arteaga, Veronica; Mitchell, Diane; Armitage, Tracey; Tancredi, Daniel; Schenker, Marc; Mitloehner, Frank

    2015-01-01

    The objective of this study was to compare the personal respiratory exposures of poultry workers in three different types of layer housing under commercial production conditions. Workers were randomly assigned to each of conventional cage, enriched cage, and aviary barns in a crossover repeated-measures design for three observation periods over the hens' lifetime. Inhalable and fine particulate matter (PM) and endotoxin in both size fractions were assessed by personal and area samplers over the work shift. Concentrations of inhalable PM, PM2.5 (PM with an aerodynamic diameter <2.5 μm), and endotoxin in both size fractions were higher in aviary than either the conventional or enriched barns. Geometric means (95% confidence intervals [CIs]) of inhalable PM and endotoxin for the aviary, conventional, and enriched barns were 8.9 (6.8-11.5) mg/m(3) and 7517.9 (5403.2-10,460.2) EU/m(3), 3.7 (2.8-4.8) mg/m(3) and 1655.7 (1144.6-2395.2) EU/m(3), 2.4 (1.8-3.3) mg/m(3) and 1404.8 (983.3-2007.0) EU/m(3), respectively. Area samplers recorded a lower mean inhalable PM concentration and higher PM2.5 concentration than personal samplers. Ammonia concentrations were low throughout three monitoring seasons. These findings show that the aviary barns pose higher respiratory exposures to poultry workers than either conventional or enriched barns.

  15. Electromechanical interaction in rotordynamics of cage induction motors

    Energy Technology Data Exchange (ETDEWEB)

    Holopainen, T.P. [VTT Industrial Systems, Espoo (Finland)

    2004-08-01

    Electromagnetic fields in the air gap of an electric machine produce electromagnetic forces between the rotor and stator. The total force exerted on the rotor due to the eccentric rotor position is called the unbalanced magnetic pull. This eccentricity force is directed roughly over the shortest air gap. At low frequencies, the vibration amplitudes of flexural modes may be large enough to couple the electromagnetic system to the mechanical one. This electromechanical inter-action changes the vibration behaviour of the system. The main purpose of this dissertation is to reveal the main rotordynamic consequences induced by the electromechanical interaction in cage induction motors. Another goal is to achieve this by deriving a simple and representative electro mechanical rotor model with physical variables and parameters. In this study, a new parametric model was derived for the unbalanced magnetic pull induced by an arbitrary rotor motion in transient operation. The parameters of this model can be determined analytically from the basis of the machine characteristics or estimated numerically as in this study. To estimate the parameters, an efficient numerical method was developed from the analysis of impulse response. The numerical results showed that the simple electromagnetic force model, together with the estimated parameters, predicts the unbalanced magnetic pull fairly accurately. An electromechanical rotor model was derived by combining the Jeffcott rotor model with the simple electromagnetic force model, including two additional variables for the harmonic currents of the rotor cage. Applying this model, the rotordynamic effects of electromechanical interaction were studied. Three induction motors were used in the numerical examples. The results obtained show that the electromechanical interaction may decrease the flexural frequencies of the rotor, induce additional damping or cause rotordynamic instability. These interaction effects are most significant in

  16. An innovative impression technique for fabrication of a custom made ocular prosthesis

    Directory of Open Access Journals (Sweden)

    Sunil Chandra Tripuraneni

    2015-01-01

    Full Text Available Various impression and fitting techniques have been described in the past for restoring ocular defects. The present article describes a new direct impression technique for recording and rehabilitating ocular defects, by custom-made ocular prosthesis. All the techniques described in the history, mainly concentrated in recording the tissue surface of the defect, which made it difficult to contour the palpebral surface resulting in the poor esthetics of the prosthesis. The present impression technique uses heavy bodied polyvinyl siloxane impression material, which facilitates accurate recording of the tissue surface and the palpebral surface of the defect, resulting in the fabrication of functionally and esthetically acceptable prosthesis.

  17. An innovative impression technique for fabrication of a custom made ocular prosthesis

    Science.gov (United States)

    Tripuraneni, Sunil Chandra; Vadapalli, Sriharsha Babu; Ravikiran, P; Nirupama, N

    2015-01-01

    Various impression and fitting techniques have been described in the past for restoring ocular defects. The present article describes a new direct impression technique for recording and rehabilitating ocular defects, by custom-made ocular prosthesis. All the techniques described in the history, mainly concentrated in recording the tissue surface of the defect, which made it difficult to contour the palpebral surface resulting in the poor esthetics of the prosthesis. The present impression technique uses heavy bodied polyvinyl siloxane impression material, which facilitates accurate recording of the tissue surface and the palpebral surface of the defect, resulting in the fabrication of functionally and esthetically acceptable prosthesis. PMID:26265651

  18. Electrotactile EMG feedback improves the control of prosthesis grasping force

    Science.gov (United States)

    Schweisfurth, Meike A.; Markovic, Marko; Dosen, Strahinja; Teich, Florian; Graimann, Bernhard; Farina, Dario

    2016-10-01

    Objective. A drawback of active prostheses is that they detach the subject from the produced forces, thereby preventing direct mechanical feedback. This can be compensated by providing somatosensory feedback to the user through mechanical or electrical stimulation, which in turn may improve the utility, sense of embodiment, and thereby increase the acceptance rate. Approach. In this study, we compared a novel approach to closing the loop, namely EMG feedback (emgFB), to classic force feedback (forceFB), using electrotactile interface in a realistic task setup. Eleven intact-bodied subjects and one transradial amputee performed a routine grasping task while receiving emgFB or forceFB. The two feedback types were delivered through the same electrotactile interface, using a mixed spatial/frequency coding to transmit 8 discrete levels of the feedback variable. In emgFB, the stimulation transmitted the amplitude of the processed myoelectric signal generated by the subject (prosthesis input), and in forceFB the generated grasping force (prosthesis output). The task comprised 150 trials of routine grasping at six forces, randomly presented in blocks of five trials (same force). Interquartile range and changes in the absolute error (AE) distribution (magnitude and dispersion) with respect to the target level were used to assess precision and overall performance, respectively. Main results. Relative to forceFB, emgFB significantly improved the precision of myoelectric commands (min/max of the significant levels) for 23%/36% as well as the precision of force control for 12%/32%, in intact-bodied subjects. Also, the magnitude and dispersion of the AE distribution were reduced. The results were similar in the amputee, showing considerable improvements. Significance. Using emgFB, the subjects therefore decreased the uncertainty of the forward pathway. Since there is a correspondence between the EMG and force, where the former anticipates the latter, the emgFB allowed for

  19. The experimental study on the magnetic bioceramic implant body cage%磁性生物陶瓷椎体间融合器的研究

    Institute of Scientific and Technical Information of China (English)

    娄朝晖; 陈安民; 李峰; 郭风劲; 李建军; 孙淑珍

    2008-01-01

    目的 检测由磁性生物陶瓷制作椎体间融合器生物愈合的可行性与稳定性.方法 应用磁性生物陶瓷制作椎体间融合器后,选健康2~4岁山羊9只,平均体重27.8kg,经氯胺酮诱导,气管插管,安氟醚吸入麻醉后,取右下腹腹膜外斜切口,暴露L3与L4椎间隙后,保留前纵韧带,从椎间隙外侧切开纤维环,摘除髓核后,牵引及撑开椎间隙,刮除软骨终板,凿去大部分椎骨表面皮质骨,植入"楔形"磁性生物陶瓷椎体间融合器.结果 9只山羊均成活,术后约8h即可恢复站立,行走;24h后恢复正常行走,进食,但是活动较少,大多数时间处于卧位,休息;3周后情况明显好转,活动恢复至正常.术后6个月,腹部彩色B超检查未见血拴形成,腹部大血管血供正常.定期X线检查,肉眼大体标本观察,光境观察,扫描电镜(SEM)观察,材料与骨实现牢固的"生物愈合".结论 采用磁性生物陶瓷制作椎体间融合器植入体内是可行的.%Objective To study the effect and stability of the magnetic bioceramic implant body cage in sheep.Methods After the L4/5 intervertebral disc of sheep was removed and replaced with the magnetic bioceramic implant body cage,the recovery of the 9 sheep was observed.The animals were killed at intervals from 1st,3nd and 5th month after operation,and the interface between the prosthesis and bone was examined by naked eye inspection,roentgenography,light and scanning electron microphotography.Results The function of the sheep was recovered rapidly,and bone bonding with the prosthesis was found,but the activity of the sheep could resume normally 3 weeks after the operation.Conclusion The replacement with the magnetic bioceramic implant body cage after removal of the intervertebral disc is effective and stable,and the biological fixation could be achieved with the bone ingrowth.

  20. Biomechanical Analysis of a Novel Prosthesis Based on the Physiological Curvature of Endplate for Cervical Disc Replacement.

    Directory of Open Access Journals (Sweden)

    Cheng-Cheng Yu

    Full Text Available Biomechanical analysis of a novel prosthesis based on the physiological curvature of endplate was performed.To compare the biomechanical differences between a novel prosthesis based on the physiological curvature of the endplate and the Prestige LP prosthesis after cervical disc replacement (CDR.Artificial disc prostheses have been widely used to preserve the physiological function of treated and adjacent motion segments in CDR, while most of those present a flat surface instead of an arcuate surface which approximately similar to anatomic structures in vivo. We first reported a well-designed artificial disc prosthesis based on the physiological curvature of the endplate.Three motion segments of 24 ovine cervical spines (C2-5 were evaluated in a robotic spine system with axial compressive loads of 50N. Testing conditions were as follows: 1 intact, 2 C3-4 CDR with artificial disc prosthesis based on the physiological curvature of the endplate, and 3 C3-4 CDR with the Prestige LP prosthesis. The range of motion (ROM and the pressures on the inferior surface of the two prostheses were recorded and analyzed.As compared to the intact state, the ROM of all three segments had no significant difference in the replacement group. Additionally, there was no significant difference in ROM between the two prostheses. The mean pressure on the novel prosthesis was significantly less than the Prestige LP prosthesis.ROM in 3 groups (intact group, CDR group with novel prosthesis and CDR group with Prestige LP showed no significant difference. The mean pressure on the inferior surface of the novel prosthesis was significantly lower than the Prestige LP prosthesis. Therefore, the novel artificial disc prosthesis is feasible and effective, and can reduce the implant-bone interface pressure on the endplate, which may be one possible reason of prosthesis subsidence.

  1. Failures of the RM finger prosthesis joint replacement system.

    Science.gov (United States)

    Middleton, A; Lakshmipathy, R; Irwin, L R

    2011-09-01

    In our unit a high failure rate of the RM finger prosthesis joint replacement system was noted, prompting a review of cases. A series of patients underwent implantation under the care of one surgeon and the results were monitored. Twenty-one devices were implanted of which 16 were inserted for rheumatoid disease. Patients were reviewed regularly and the implant performance was assessed critically along with survival of the implant to revision, infection or death of the patient. The mean follow-up was 32 months. Unacceptable failure rates at early and medium term stages were identified, with 15 of the implants revised by 2 years. Loosening was the commonest mode of failure. The authors do not recommend the use of this implant, especially in cases of rheumatoid arthritis.

  2. The functional performance of the Argus II retinal prosthesis.

    Science.gov (United States)

    Stronks, H Christiaan; Dagnelie, Gislin

    2014-01-01

    Visual prostheses are devices to treat profound vision loss by stimulating nerve cells anywhere along the visual pathway, typically with electrical pulses. The Argus II implant, developed by Second Sight Medical Products (SSMP, Sylmar, CA, USA), targets the retina and features 60 electrodes that electrically stimulate the surviving retinal neurons. Of the approximately 20 research groups that are actively developing visual prostheses, SSMP has the longest track record. The Argus II was the first visual prosthesis to become commercially available: it received the European conformity mark in 2011 and FDA approval was granted in early 2013 for humanitarian use in the USA. Meanwhile, the Argus II safety/benefit study has been extended for research purposes, and is still ongoing. In this review, we will discuss the performance of the Argus II in restoring sight to the blind, and we will shed light on its expected developments in the coming years.

  3. Effect of 2 Bedding Materials on Ammonia Levels in Individually Ventilated Cages.

    Science.gov (United States)

    Koontz, Jason M; Kumsher, David M; Kelly, Richard; Stallings, Jonathan D

    2016-01-01

    This study sought to identify an optimal rodent bedding and cage-change interval to establish standard procedures for the IVC in our rodent vivarium. Disposable cages were prefilled with either corncob or α-cellulose bedding and were used to house 2 adult Sprague-Dawley rats (experimental condition) or contained no animals (control). Rats were observed and intracage ammonia levels measured daily for 21 d. Intracage ammonia accumulation became significant by day 8 in experimental cages containing α-cellulose bedding, whereas experimental cages containing corncob bedding did not reach detectable levels of ammonia until day 14. In all 3 experimental cages containing α-cellulose, ammonia exceeded 100 ppm (our maximum acceptable limit) by day 11. Two experimental corncob cages required changing at days 16 and 17, whereas the remaining cage containing corncob bedding lasted the entire 21 d without reaching the 100-ppm ammonia threshold. These data suggests that corncob bedding provides nearly twice the service life of α-cellulose bedding in the IVC system.

  4. Effect of 2 Bedding Materials on Ammonia Levels in Individually Ventilated Cages

    Science.gov (United States)

    Koontz, Jason M; Kumsher, David M; III, Richard Kelly; Stallings, Jonathan D

    2016-01-01

    This study sought to identify an optimal rodent bedding and cage-change interval to establish standard procedures for the IVC in our rodent vivarium. Disposable cages were prefilled with either corncob or α-cellulose bedding and were used to house 2 adult Sprague–Dawley rats (experimental condition) or contained no animals (control). Rats were observed and intracage ammonia levels measured daily for 21 d. Intracage ammonia accumulation became significant by day 8 in experimental cages containing α-cellulose bedding, whereas experimental cages containing corncob bedding did not reach detectable levels of ammonia until day 14. In all 3 experimental cages containing α-cellulose, ammonia exceeded 100 ppm (our maximum acceptable limit) by day 11. Two experimental corncob cages required changing at days 16 and 17, whereas the remaining cage containing corncob bedding lasted the entire 21 d without reaching the 100-ppm ammonia threshold. These data suggests that corncob bedding provides nearly twice the service life of α-cellulose bedding in the IVC system. PMID:26817976

  5. Suitability of carbon fiber-reinforced polyetheretherketone cages for use as anterior struts following corpectomy.

    Science.gov (United States)

    Heary, Robert F; Parvathreddy, Naresh K; Qayumi, Zainab S; Ali, Naiim S; Agarwal, Nitin

    2016-08-01

    OBJECTIVE Fibular allograft remains a widely used strut for corpectomy surgeries. The amount of graft material that can be packed into an allograft strut has not been quantified. Cages are an alternative to fibular allograft for fusion surgeries. The authors of this study assessed the suitability of carbon fiber-reinforced polyetheretherketone (CFRP) cages for anterior corpectomy surgeries. They further explored the parameters known to affect fusion rates in clinical practice. METHODS Six fibular allografts were tested at standard lengths. Three sets of carbon fiber cages (Bengal, DePuy Spine), each with a different footprint size but the same lengths, were tested. The allografts and cages were wrapped in adhesive, fluid-tight transparent barriers and filled with oil. The volume and weight of the oil instilled as well as the implant footprints were measured. The fibular allografts and cages were tested at 20-, 40-, and 50-mm lengths. Two investigators independently performed all measurements 5 times. Five CFRP cubes (1 × 1 × 1 cm) were tested under pure compression, and load versus displacement curves were plotted to determine the modulus of elasticity. RESULTS Significantly more oil fit in the CFRP cages than in the fibular allografts (p Carbon fiber-reinforced polyetheretherketone cages can accommodate much more graft material than can fibular allografts. In clinical practice, the ability to deliver greater amounts of graft material following a corpectomy may improve fusion rates.

  6. Digestibility and behavior of dogs housed in kennels or metabolic cages

    Directory of Open Access Journals (Sweden)

    Tabyta Tamara Sabchuk

    2012-01-01

    Full Text Available The objective of the present study was to compare the apparent digestibility coefficients of a commercial dog food, fecal consistency and behavior of dogs housed in kennels and metabolic cages. Six adult Beagle dogs were distributed in cross-over experimental design, with six replicates per treatment. Dogs were housed in two environments: metabolic cages and in masonry kennels with solarium. Dogs were fed for a five-day adaptation period, and the five following days were used for total feces collection. Dogs behavior was recorded during a 48-h period, with 10-min intervals. Apparent digestibility coefficients were not different between treatments. However, dogs housed in metabolic cages produced lower weight and more consistent feces as compared with dogs housed in kennels. Dogs spent most of the time sleeping in both housing systems; however, dogs housed in the metabolic cages slept more than those in kennels. Stress-related behaviors (barking, whimpering, stereotypies, etc were observed for no longer than 15 minutes per day, and were not different between dogs in kennels or in cages. There is no difference in food digestibility evaluated in dogs housed in metabolic cages or kennels; however, dogs kept in metabolic cages eliminate drier feces and spend more time inactive than those kept in kennels.

  7. Individually ventilated cages cause chronic low-grade hypoxia impacting mice hematologically and behaviorally

    Science.gov (United States)

    York, Jason M.; McDaniel, Allison W.; Blevins, Neil A.; Guillet, Riley R.; Allison, Sarah O.; Cengel, Keith A.; Freund, Gregory G.

    2012-01-01

    Use of individually ventilated caging (IVC) systems for mouse-based laboratory investigation has dramatically increased. We found that without mice present, intra-cage oxygen concentration was comparable (21%) between IVC housing and ambient environment caging (AEC) that used wire top lids. However, when mice were housed 4-to-a-cage for 1 week, intra-cage oxygen dropped to 20.5% in IVC housing as compared to 21% for AEC housing. IVC intra-cage humidity was also elevated relative to AEC housing. Mice raised in IVC housing as compared to mice raised in AEC housing had higher RBC mass, hematocrit and hemoglobin concentrations. They also had elevated platelet counts but lower white blood cell counts. IVC mice relative to AEC mice had increased saccharin preference and increased fluid consumption but similar locomotion, food intake, social exploration and novel object recognition when tested in an AEC environment. Taken together, these data indicate that ventilated caging systems can have a 0.5% reduction from ambient oxygen concentration that is coupled to mouse red blood cell indices indicative of chronic exposure to a hypoxia. Importantly, IVC housing can impact behavioral testing for depressive-like behavior. PMID:22561683

  8. Effect of curcumin caged silver nanoparticle on collagen stabilization for biomedical applications.

    Science.gov (United States)

    Srivatsan, Kunnavakkam Vinjimur; Duraipandy, N; Begum, Shajitha; Lakra, Rachita; Ramamurthy, Usha; Korrapati, Purna Sai; Kiran, Manikantan Syamala

    2015-04-01

    The current study aims at understanding the influence of curcumin caged silver nanoparticle (CCSNP) on stability of collagen. The results indicated that curcumin caged silver nanoparticles efficiently stabilize collagen, indicated by enhanced tensile strength, fibril formation and viscosity. The tensile strength of curcumin caged silver nanoparticle cross-linked collagen and elongation at break was also found to be higher than glutaraldehyde cross-linked collagen. The physicochemical characteristics of curcumin caged nanoparticle cross-linked collagen exhibited enhanced strength. The thermal properties were also good with both thermal degradation temperature and hydrothermal stability higher than native collagen. CD analysis showed no structural disparity in spite of superior physicochemical properties suggesting the significance of curcumin caged nanoparticle mediated cross-linking. The additional enhancement in the stabilization of collagen could be attributed to multiple sites for interaction with collagen molecule provided by curcumin caged silver nanoparticles. The results of cell proliferation and anti-microbial activity assays indicated that curcumin caged silver nanoparticles promoted cell proliferation and inhibited microbial growth making it an excellent biomaterial for wound dressing application. The study opens scope for nano-biotechnological strategies for the development of alternate non-toxic cross-linking agents facilitating multiple site interaction thereby improving therapeutic values to the collagen for biomedical application.

  9. Computational design and fabrication of a novel bioresorbable cage for tibial tuberosity advancement application.

    Science.gov (United States)

    Castilho, Miguel; Rodrigues, Jorge; Vorndran, Elke; Gbureck, Uwe; Quental, Carlos; Folgado, João; Fernandes, Paulo R

    2017-01-01

    Tibial tuberosity advancement (TTA) is a promising method for the treatment of cruciate ligament rupture in dogs that usually implies the implantation of a titanium cage as bone implant. This cage is non-biodegradable and fails in providing adequate implant-bone tissue integration. The objective of this work is to propose a new process chain for designing and manufacturing an alternative biodegradable cage that can fulfill specific patient requirements. A three-dimensional finite element model (3D FEM) of the TTA system was first created to evaluate the mechanical environment at cage domain during different stages of the dog walk. The cage microstructure was then optimized using a topology optimization tool, which addresses the accessed local mechanical requirements, and at same time ensures the maximum permeability to allow nutrient and oxygen supply to the implant core. The designed cage was then biofabricated by a 3D powder printing of tricalcium phosphate cement. This work demonstrates that the combination of a 3D FEM with a topology optimization approach enabled the design of a novel cage for TTA application with tailored permeability and mechanical properties, that can be successfully 3D printed in a biodegradable bioceramic material. These results support the potential of the design optimization strategy and fabrication method to the development of customized and bioresorbable implants for bone repair.

  10. Growth of uniform CaGe2 films by alternating layer molecular beam epitaxy

    Science.gov (United States)

    Xu, Jinsong; Katoch, Jyoti; Ahmed, Adam S.; Pinchuk, Igor V.; Young, Justin R.; Johnston-Halperin, Ezekiel; Pelz, Jonathan; Kawakami, Roland K.

    2017-02-01

    Layered Zintl phase van der Waals (vdW) materials are of interest due to their strong spin-orbit coupling and potential for high mobility. Here, we report the successful growth of large area CaGe2 films, as a model of layered Zintl phase materials, on atomically flat Ge(111) substrates by molecular beam epitaxy (MBE) using an alternating layer growth (ALG) protocol. Reflection high energy electron diffraction (RHEED) patterns of the Ge buffer layer and CaGe2 indicate high quality two dimensional surfaces, which is further confirmed by atomic force microscopy (AFM), showing atomically flat and uniform CaGe2 films. The appearance of Laue oscillations in X-ray diffraction (XRD) and Kiessig fringes in the X-ray reflectivity (XRR), which are absent in co-deposited CaGe2, confirms the uniformity of the CaGe2 film and the smoothness of the interface. These results demonstrate a novel method of deposition of CaGe2 that could be also applied to other layered Zintl phase vdW materials. Also, the high quality of the CaGe2 film is promising for the exploration of novel properties of germanane.

  11. Restoration of an atrophic eye socket with custom made eye prosthesis, utilizing digital photography

    Directory of Open Access Journals (Sweden)

    Gaurav P Jayaswal

    2011-01-01

    Full Text Available Ocular defects may cause several ocular and orbital disorders, which require surgical intervention. These defects are psychologically disturbing for the patients, and therefore, they require immediate management and rehabilitation by a team of specialist. Ocular prosthesis may be either readymade (stock or custom made. Fabrication of a custom ocular prosthesis allows for a range of variations during construction. The iris can also be custom made by ocular painting or by digital photography. The optimum cosmetic and functional results of a custom-made prosthesis enhance the patient′s rehabilitation to a normal life style. This paper elaborates the technique for fabrication of a custom-made ocular prosthesis for an atrophic eye socket utilizing digital photography.

  12. Development of a patient specific artificial tracheal prosthesis: design, mechanical behavior analysis and manufacturing.

    Science.gov (United States)

    Chua C H, Matthew; Chui, Chee Kong; Rai, Bina; Lau D P, David

    2013-01-01

    There is a need to create patient specific organ replacements as there are differences in the anatomical dimensions among individuals. High failure rates in tracheal prosthesis are attributed to the lack of mechanical strength and flexibility, slow rate of growth of ciliated epithelium and leakage of interstitial fluid into the lumen. This paper proposes a methodology of design, simulations and fabrication of a patient specific artificial tracheal prosthesis for implantation to closely mimic the biomechanical properties of the natural trachea, and describes the prototype device and its materials. Results show that the patient-specific trachea prosthesis has mechanical properties approximate that of normal tracheal rings. The user centric tracheal prosthesis is demonstrated to be a promising candidate for tracheal replacement.

  13. Rehabilitation of a Partial Nasal Defect with Facial Prosthesis: A Case Report

    Science.gov (United States)

    Negahdari, Ramin; Pournasrollah, Alireza; Bohlouli, Sepideh; Sighari Deljavan, Alireza

    2014-01-01

    >Malignancies of the midface result in cosmetic deformities that make maxillofacial prosthesis as an integral part of the treatment plan. Facial defects can be devastating in their impact on physical structure and function of the affected individual, leading to potentional compromises in quality of life. Reconstruction of nasal defects is a challenge for the prosthodontist because of esthetic and retention problems associated with the facial prosthesis. This paper reports the rehabilitation of a partial nasal defect caused by basal cell carcinoma treatment using a nasal prosthesis made with silicone elastomers and mechanical and anatomical retentive aids. The patient had no problem with the prosthesis, except for a partial loss of extrinsic coloration in the two-year follow-up. PMID:25587390

  14. Rehabilitation of Digital Defect with Silicone Finger Prosthesis: A Case Report

    Science.gov (United States)

    Saxena, Deepesh; Jurel, Sunit; Gupta, Ajay; Tomar, Divya

    2014-01-01

    Patients with acquired defects often had severe trauma which leads to psychological instability, functional loss and poor aesthetics. Digital defects threaten the integrity of one’s self esteem and also leads to a reduced and compromised function. A well fitted and colour matched finger prosthesis can make a patient feel a capable person and not a handicap. This article describes a technique for fabrication of custom made finger prosthesis with a silicone elastomer. The customization of the prosthesis leads to a better fit and retention. An excellent shade matching is achieved by the use of intrinsic colours. The other advantages of using silicone as a material of choice for prosthesis fabrication are also discussed. PMID:25302277

  15. Outcome of uncemented trapeziometacarpal prosthesis for treatment of thumb carpometacarpal joint arthritis

    Directory of Open Access Journals (Sweden)

    Manish Chug

    2014-01-01

    Conclusion: The use of uncemented prosthesis in treatment of Questionnaire Score. Range of motion joint osteoarthritis gives excellent short term results in improving hand function in terms of strength and stability and achieving pain relief.

  16. Use of the Argus II retinal prosthesis to improve visual guidance of fine hand movements

    OpenAIRE

    2012-01-01

    We studied the capabilities of the Argus II retinal prosthesis for guiding fine hand movement, and demonstrated and quantified guidance improvement when using the device over when not using the device for progressively less predictable trajectories.

  17. Short-Term Effect of Prosthesis Transforming Sensory Modalities on Walking in Stroke Patients with Hemiparesis

    Directory of Open Access Journals (Sweden)

    Dai Owaki

    2016-01-01

    Full Text Available Sensory impairments caused by neurological or physical disorders hamper kinesthesia, making rehabilitation difficult. In order to overcome this problem, we proposed and developed a novel biofeedback prosthesis called Auditory Foot for transforming sensory modalities, in which the sensor prosthesis transforms plantar sensations to auditory feedback signals. This study investigated the short-term effect of the auditory feedback prosthesis on walking in stroke patients with hemiparesis. To evaluate the effect, we compared four conditions of auditory feedback from plantar sensors at the heel and fifth metatarsal. We found significant differences in the maximum hip extension angle and ankle plantar flexor moment on the affected side during the stance phase, between conditions with and without auditory feedback signals. These results indicate that our sensory prosthesis could enhance walking performance in stroke patients with hemiparesis, resulting in effective short-term rehabilitation.

  18. Clinical results of biologic prosthesis: A systematic review and meta-analysis of comparative studies

    Directory of Open Access Journals (Sweden)

    Chumpon Wilasrusmee

    2017-03-01

    Conclusions: Our first meta-analysis indicated that the biosynthetic prosthesis might be benefit over PTFE by increasing graft patency. An updated meta-analysis or a large scale randomized control trial is required to confirm this benefit.

  19. Low home cage social behaviors in BTBR T+tf/J mice during juvenile development.

    Science.gov (United States)

    Babineau, Brooke A; Yang, Mu; Berman, Robert F; Crawley, Jacqueline N

    2013-04-10

    BTBR T+tf/J (BTBR) is a genetically homogenous inbred strain of mice that displays abnormal social behaviors, deficits in vocalizations, and high levels of repetitive behaviors, relevant to the three diagnostic symptoms of autism spectrum disorder, leading to the use of this strain as a mouse model of autism. Comprehensive observations of BTBR social behaviors within the home cage during early stages of development have not been conducted. Here we evaluate the home cage behaviors of BTBR in two laboratory environments (NIMH, Bethesda, Maryland vs. UC Davis, Davis, California), starting from the day of weaning and continuing into adulthood. Extensive ethogram parameters were scored for BTBR in home cages that contained four BTBR conspecifics, versus home cages that contained four C57BL/6J (B6) conspecifics. BTBR were considerably less interactive than B6 in the home cage at both sites, as measured during the early dark stage of their circadian cycle. A novel home cage behavioral measure, frequency of long interactions, was found to be more frequent and of longer duration in B6 versus BTBR home cages across experimental sites. Significant strain differences in the occurrence of investigative and affiliative behaviors were also seen, however these findings were not fully consistent across the two testing sites. At the end of the 30-day home cage observation period, each seven-week old subject mouse was tested in the three-chambered social approach task. BTBR displayed lack of sociability and B6 displayed significant sociability, consistent with previous reports. Our findings reveal that BTBR engaged in lower levels of some components of spontaneous conspecific social interactions in the home cage environment throughout juvenile development, consistent with their deficits in juvenile and adult sociability as measured in specialized social tasks.

  20. Impact of prosthesis-patient mismatch on survival after mitral valve replacement: a systematic review

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jian-feng; WU Yi-cheng; SHEN Wei-feng; KONG Ye

    2013-01-01

    Objective To determine whether the prosthesis-patient mismatch has a deleterious impact on survival after mitral valve replacement.Data sources A comprehensive literature search of PubMed,Embase,and ScienceDirect was carried out.References and cited papers of relevant articles were also checked.Study selection All articles published after January 1980 was initially considered.Non-English and non-human studies,case reports,and reviews were excluded from the initial search.References and cited papers of relevant articles were also checked.Results A total of 8 retrospective cohort studies were identified for this review.The overall incidence of prosthesis-patient mismatch (<1.3 to <1.2 cm2/m2) after mitral valve replacement ranged from 3.7% to 85.9% (moderate prosthesis-patient mismatch (0.9 to 1.2 cm2/m2) in 37.4% to 69.5%,severe prosthesis-patient mismatch (<0.9 cm2/m2) in 8.7% to 16.4%).Four studies demonstrated an association of prosthesis-patient mismatch with reduced long-term survival,but the other four studies found no significant deleterious impact of prosthesis-patient mismatch after mitral valve replacement.No definite conclusion could be derived from these conflicting results.Conclusions Current evidence is insufficient to derive a definite conclusion whether mitral prosthesis-patient mismatch affects long-term survival because of the biases and confounding factors that interfere with late clinical outcomes.Good-quality prospective studies are warranted to evaluate the impact of mitral prosthesis-patient mismatch after mitral valve replacement in the future.

  1. Testicular prosthesis: Patient satisfaction and sexual dysfunctions in testis cancer survivors

    Directory of Open Access Journals (Sweden)

    Francesco Catanzariti

    2016-10-01

    Full Text Available Purpose: We studied patient satisfaction about sexual activity after prosthesis implantation using validated questionnaires with the aim to discover if testicular prosthesis could be responsible of sexual dysfunctions (erectile dysfunction or premature ejaculation. Materials and Methods: We evaluated a total of 67 men who underwent radical orchiectomy for testicular cancer and a silicon testicular prosthesis implantation from January 2008 to June 2014 at our Hospital. These patients completed 5 validated questionnaires the day before orchiectomy and 6 months after surgery: the International Index of Erectile Function 5 (IIEF5, the Premature Ejaculation Diagnostic Tool (PEDT, the Body Exposure during Sexual Activities Questionnaire (BESAQ, the Body-Esteem Scale and the Rosenberg Self- Esteem Scale. We also evaluated 6 months after surgery any defects of the prosthesis complained by the patients. Results: The questionnaires completed by patients didn’t show statistically significant changes for erectile dysfunction (p > 0.05 and premature ejaculation (p > 0.05. On the contrary the psychological questionnaires showed statistically significant change for the BESAQ (p < 0.001 and the Body Esteem Scale (p < 0.001, but not for the Rosenberg Self-Esteem Scale (p > 0,05. A total of 15 patients (22.37% were dissatisfied about the prosthesis: the most frequent complaint (8 patients; 11.94% was that the prosthesis was firmer than the normal testis. Conclusions: Testicular prosthesis implantation is a safe surgical procedure that should be always proposed before orchiectomy for cancer of the testis. The defects complained by patients with testicular prosthesis are few, they don’t influence sexual activity and they aren’t able to cause erectile dysfunction or premature ejaculation.

  2. Patient-prosthesis mismatch and reduction in left ventricular mass after aortic valve replacement

    DEFF Research Database (Denmark)

    Kandler, Kristian; Møller, Christian H; Hassager, Christian;

    2013-01-01

    The presence of patient-prosthesis mismatch (PPM) after aortic valve replacement may influence patient survival. We examined the relationship between PPM and changes in left ventricular mass index at 3 months follow-up and also overall survival.......The presence of patient-prosthesis mismatch (PPM) after aortic valve replacement may influence patient survival. We examined the relationship between PPM and changes in left ventricular mass index at 3 months follow-up and also overall survival....

  3. Strut fracture in the new Bjørk-Shiley mitral valve prosthesis.

    Science.gov (United States)

    Brubakk, O; Simonsen, S; Källman, L; Fredriksen, A

    1981-04-01

    The case of a patient with the new type Bjørk-Shiley aortic and mitral valve prosthesis is described. Three months after implant she suffered acute heart failure and died. Post-mortem examination revealed a fractured outlet strut in the mitral valve prosthesis with dislocation of the disc. The fracture was regarded as due to excessive brittleness caused by demonstrated deposition of chromium-tungsten-carbide.

  4. Three-year outcomes after transcatheter aortic valve implantation with the CoreValve prosthesis.

    Science.gov (United States)

    Gotzmann, Michael; Czauderna, Anna; Hehnen, Tobias; Aweimer, Assem; Lind, Alexander; Kloppe, Axel; Bösche, Leif; Mügge, Andreas; Ewers, Aydan

    2014-08-15

    There is little known about the long-term results of the CoreValve prosthesis. The aim of this study was to assess the 3-year clinical and hemodynamic outcomes of the CoreValve prosthesis. One hundred fifty consecutive patients with severe aortic stenosis successfully underwent transcatheter aortic valve implantation (TAVI) with the CoreValve prosthesis. The primary study end point was death from any cause after TAVI. The secondary end points were defined as (1) cardiovascular death and (2) prosthesis-related mortality and morbidity. At 1 to 3 years, all-cause mortality rates were 25%, 32%, and 41%, respectively, and cardiovascular mortality rates were 14%, 21%, and 27%, respectively. Before TAVI, 95% of patients were in New York Heart Association class III or IV. Of the surviving patients, rates of New York Heart Association class III or IV at 1 to 3 years were 33%, 39%, and 38%, respectively. There was an annual decrease of the valve area of approximately 0.1 cm². Aortic restenosis occurred in 2 patients. Moderate or severe aortic regurgitation (AR) occurred in 15% of patients immediately after TAVI. Twenty patients (13%) had a slight worsening of AR within 3 years. New severe AR did not occur. The incidence of prosthesis-related endocarditis was 0.66% per year. Overall, 7 patients (incidence of 1.5% per year) had a clinically relevant problem of the prosthesis. In conclusion, TAVI with the CoreValve prosthesis had favorable effects on symptoms and outcomes even after 3 years. These results are clouded by side effects, such as AR and prosthesis-related mortality and morbidity.

  5. Spiro annulation of cage polycycles via Grignard reaction and ring-closing metathesis as key steps

    Directory of Open Access Journals (Sweden)

    Sambasivarao Kotha

    2015-08-01

    Full Text Available A simple synthetic strategy to C2-symmetric bis-spiro-pyrano cage compound 7 involving ring-closing metathesis is reported. The hexacyclic dione 10 was prepared from simple and readily available starting materials such as 1,4-naphthoquinone and cyclopentadiene. The synthesis of an unprecedented octacyclic cage compound through intramolecular Diels–Alder (DA reaction as a key step is described. The structures of three new cage compounds 7, 12 and 18 were confirmed by single crystal X-ray diffraction studies.

  6. A Perspective on the Synthesis, Purification, and Characterization of Porous Organic Cages.

    Science.gov (United States)

    Briggs, Michael E; Cooper, Andrew I

    2017-01-10

    Porous organic cages present many opportunities in functional materials chemistry, but the synthetic challenges for these molecular solids are somewhat different from those faced in the areas of metal-organic frameworks, covalent-organic frameworks, or porous polymer networks. Here, we highlight the practical methods that we have developed for the design, synthesis, and characterization of imine porous organic cages using CC1 and CC3 as examples. The key points are transferable to other cages, and this perspective should serve as a practical guide to researchers who are new to this field.

  7. Genome-wide detection and analysis of hippocampus core promoters using DeepCAGE

    DEFF Research Database (Denmark)

    Valen, Eivind; Pascarella, Giovanni; Chalk, Alistair;

    2009-01-01

    in a given tissue. Here, we present a new method for high-throughput sequencing of 5' cDNA tags-DeepCAGE: merging the Cap Analysis of Gene Expression method with ultra-high-throughput sequence technology. We apply DeepCAGE to characterize 1.4 million sequenced TSS from mouse hippocampus and reveal a wealth...... of novel core promoters that are preferentially used in hippocampus: This is the most comprehensive promoter data set for any tissue to date. Using these data, we present evidence indicating a key role for the Arnt2 transcription factor in hippocampus gene regulation. DeepCAGE can also detect promoters...

  8. Bionic ankle–foot prosthesis normalizes walking gait for persons with leg amputation

    Science.gov (United States)

    Herr, Hugh M.; Grabowski, Alena M.

    2012-01-01

    Over time, leg prostheses have improved in design, but have been incapable of actively adapting to different walking velocities in a manner comparable to a biological limb. People with a leg amputation using such commercially available passive-elastic prostheses require significantly more metabolic energy to walk at the same velocities, prefer to walk slower and have abnormal biomechanics compared with non-amputees. A bionic prosthesis has been developed that emulates the function of a biological ankle during level-ground walking, specifically providing the net positive work required for a range of walking velocities. We compared metabolic energy costs, preferred velocities and biomechanical patterns of seven people with a unilateral transtibial amputation using the bionic prosthesis and using their own passive-elastic prosthesis to those of seven non-amputees during level-ground walking. Compared with using a passive-elastic prosthesis, using the bionic prosthesis decreased metabolic cost by 8 per cent, increased trailing prosthetic leg mechanical work by 57 per cent and decreased the leading biological leg mechanical work by 10 per cent, on average, across walking velocities of 0.75–1.75 m s−1 and increased preferred walking velocity by 23 per cent. Using the bionic prosthesis resulted in metabolic energy costs, preferred walking velocities and biomechanical patterns that were not significantly different from people without an amputation. PMID:21752817

  9. The reverse shoulder prosthesis: a review of imaging features and complications

    Energy Technology Data Exchange (ETDEWEB)

    McFarland, Edward G.; Sanguanjit, Prakasit; Tasaki, Atsushi [Johns Hopkins University, Department of Orthopedic Surgery, Lutherville, MD (United States); Keyurapan, Ekavit [Mahidol University, Department of Orthopaedic Surgery, Bangkok (Thailand); Fishman, Elliot K.; Fayad, Laura M. [Johns Hopkins Medical Institutions, Johns Hopkins University, Department of Radiology and Radiological Sciences, Baltimore, MD (United States)

    2006-07-15

    The reverse shoulder prosthesis is a prosthesis that has been in clinical use in Europe since 1985 and was approved for use in the United States in 2004. This unique prosthesis has a baseplate attached to the glenoid, which holds a spherical component, while the humeral component includes a polyethylene insert that is flat. This design is the ''reverse'' configuration of that seen with a conventional arthroplasty, in which the spherical component is part of the humeral component. The indications for the reverse prosthesis are: (1) painful arthritis associated with irreparable rotator cuff tears (cuff tear arthropathy), (2) failed hemiarthroplasty with irreparable rotator cuff tears, (3) pseudoparalysis due to massive, irreparable rotator cuff tears, (4) some reconstructions after tumor resection, and (5) some fractures of the shoulder not repairable or reconstructable with other techniques. This prosthesis can produce a significant reduction in pain and some improvement in function for most of the indications mentioned. However, the unique configuration and the challenge of its insertion can result in a high incidence of a wide variety of unusual complications. Some of these complications, such as dislocation of the components, are similar to conventional shoulder replacement. Other complications, such as notching of the scapula and acromial stress fractures, are unique to this prosthesis. (orig.)

  10. Advanced engineering tools for design and fabrication of a custom nasal prosthesis

    Science.gov (United States)

    Oliveira, Inês; Leal, Nuno; Silva, Pedro; da Costa Ferreira, A.; Neto, Rui J.; Lino, F. Jorge; Reis, Ana

    2012-09-01

    Unexpected external defects resulting from neoplasms, burns, congenital malformations, trauma or other diseases, particularly when involving partial or total loss of an external organ, can be emotionally devastating. These defects can be restored with prosthesis, obtained by different techniques, materials and methods. The increase of patient numbers and cost constraints lead to the need of exploring new techniques that can increase efficiency. The main goal of this project was to develop a full engineering-based manufacturing process to obtain soft-tissue prosthesis that could provide faster and less expensive options in the manufacturing of customized prosthesis, and at the same time being able to reproduce the highest degree of details, with the maximum comfort for the patient. Design/methodology/approach - This case report describes treatment using silicone prosthesis with an anatomic retention for an 80-years-old woman with a rhinectomy. The proposed methodology integrates non-contact structured light scanning, CT and reverse engineering with CAD/CAM and additive manufacturing technology. Findings - The proposed protocol showed encouraging results since reveals being a better solution for fabricating custom-made facial prostheses for asymmetrical organs than conventional approaches. The process allows the attainment of prosthesis with the minimum contact and discomfort for the patient, disclosing excellent results in terms of aesthetic, prosthesis retention and in terms of time and resources consumed.

  11. Plasticity in the visual system is associated with prosthesis use in phantom limb pain

    Directory of Open Access Journals (Sweden)

    Sandra ePreißler

    2013-06-01

    Full Text Available The experience of strong phantom limb pain (PLP in arm amputees was previously shown to be associated with structural neural plasticity in parts of the cortex that belong to dorsal and ventral visual streams. It has been speculated that this plasticity results from the extensive use of a functional prosthesis which is associated with increased visual feedback to control the artificial hand.To test this hypothesis, we reanalyzed data of cortical volumes of 21 upper limb amputees and tested the association between the amount of use of the hand prosthesis and cortical volume plasticity.On the behavioral level, we found no relation between PLP and the amount of prosthesis use for the whole patient group. However, by subdividing the patient group into patients with strong PLP and those with low to medium PLP, stronger pain was significantly associated with less prosthesis use whereas the group with low PLP did not show such an association.Most plasticity of cortical volume was identified within the dorsal stream. The more the patients that suffered from strong PLP used their prosthesis, the smaller was the volume of their posterior parietal cortex.Our data indicate a relationship between prosthesis use and cortical plasticity of the visual stream. This plasticity might present a brain adaption process to new movement and coordination patterns needed to guide an artificial hand.

  12. Bionic ankle-foot prosthesis normalizes walking gait for persons with leg amputation.

    Science.gov (United States)

    Herr, Hugh M; Grabowski, Alena M

    2012-02-07

    Over time, leg prostheses have improved in design, but have been incapable of actively adapting to different walking velocities in a manner comparable to a biological limb. People with a leg amputation using such commercially available passive-elastic prostheses require significantly more metabolic energy to walk at the same velocities, prefer to walk slower and have abnormal biomechanics compared with non-amputees. A bionic prosthesis has been developed that emulates the function of a biological ankle during level-ground walking, specifically providing the net positive work required for a range of walking velocities. We compared metabolic energy costs, preferred velocities and biomechanical patterns of seven people with a unilateral transtibial amputation using the bionic prosthesis and using their own passive-elastic prosthesis to those of seven non-amputees during level-ground walking. Compared with using a passive-elastic prosthesis, using the bionic prosthesis decreased metabolic cost by 8 per cent, increased trailing prosthetic leg mechanical work by 57 per cent and decreased the leading biological leg mechanical work by 10 per cent, on average, across walking velocities of 0.75-1.75 m s(-1) and increased preferred walking velocity by 23 per cent. Using the bionic prosthesis resulted in metabolic energy costs, preferred walking velocities and biomechanical patterns that were not significantly different from people without an amputation.

  13. Custom-made tumor prosthesis fracture and prosthesis design%定制肿瘤假体断裂因素与假体设计

    Institute of Scientific and Technical Information of China (English)

    荀建军; 李艳芳

    2011-01-01

    背景:因肿瘤型假体置换后并发症而再次手术的患者不断增加,其定制肿瘤假体的断裂是原因之一.目的:总结分析定制肿瘤假体发生断裂的原因,以及其与假体设计的关系.方法:以"定制肿瘤假体,假体断裂"为中文关键词;"Custom-made prosthesis, Endoprosthesis fatigue fracture"为英文关键词.采用计算机检索2000-01/2010-12相关文章.纳入与有关定制肿瘤假体设计及假体断裂翻修相关的文章;排除重复研究或Meta分析类文章.以14篇文献为主重点进行了讨论.结果与结论:假体断裂的原因主要有假体设计缺陷,假体材料、加工工艺不合格,放置失误,手术软组织重建困难及缺少骨支撑等方面.通过了解肿瘤假体应力集中部位及应力峰值,可以预测内固定系统的寿命.%BACKGROUND: The number of patients receiving second operation due to complications after tumor prosthesis replacement is increasing, and custom-made prosthesis fractu re is one of the reasons.OBJECTIVE: To analyze the reasons for custom-made prosthesis fracture, and to investigate their relationship with prosthesisdesign.METHODS: A computer retrieve was performed for related articles published from January 2000 to December 2010 using keywords of "custom-made prosthesis, endoprosthesis fatigue fracture' in Chinese and English. Articles about custom-made prosthesis fracture and design were included. Repetitive articles or Meta analysis were excluded. Totally 14 articles were included in result analysis.RESULTS AND CONCLUSION: The main reasons for prosthesis fracture included design defects, material and process failure,place errors, difficulty in soft tissue reconstruction, and lack of bone support, and so on. The life of fixation system could be predicted based on prosthesis stress site and peak.

  14. EVALUTION OF EFFECTIVENESS OF BALANCE TRAINING IN CONVENTIONAL PROSTHESIS VERSUS ULTRAMODERN PROSTHESIS IN UNILATERAL TRANSTIBIAL AMPUTEE BY USING FLAMINGO BALANCE TEST

    Directory of Open Access Journals (Sweden)

    Suresh

    2014-08-01

    Full Text Available AIM: To estimate the effectiveness of balance training on unilateral transtibal amputee with conventional prosthesis and ultramodern prosthesis. To compare the Effectiveness of balance training in conventional prosthesis versus ultramodern prosthesis in unilateral transtibial amputee by using Flamingo balance test. MATERIALS AND METHODS: After obtaining informed consent from the patients, we studied a total of 40 patients, aged between 30- 60 yrs, where they were randomly allocated into two groups. 20 patients in Group A with conventional prosthesis and 20 patients with ultramodern prosthesis in group B were subjected to 3 weeks of structured exercise programme after initial assessment of balance with Flamingo’s balance test and ten metre walk test. These tests were repeated in repeated in both the groups after the exercise programme and the results were tabulated and analysed. RESULTS: The mean age of population in group A was 50.55± 7.20 and in group B was 48.55±5.58, with age group ranging from 30 – 60 yrs. In group A the pre and post interventions mean values in Flamingo’s balance test were 15.55±2.58 and 13.05±3.05 respectively. In group B the pre and post intervention mean values were 12.35±1.26 and 8.3±0.86 respectively. In group A the pre and post interventions mean values in ten metre walk test are 45.00±3.62 and 35.00±6.39 respectively. In group B the pre and post intervention mean value are 40.00±4.29 and 26.70±2.95 respectively. The mean difference of balance using Flamingo Balance test during pre and post intervention in both the groups were compared using independent ‘t‘ test, which showed (t of 4.971 vs 6.805 in Groups A and B respectively; p=000*. The mean difference of balance in both the groups for ten metre walk test were t of 3.979 vs 5.650 in Groups A and B respectively (; p= 000*. CONCLUSION: In both groups there are statistically significant improvements in scores flamingo balance test and 10mt. walk

  15. Intermolecular hydrogen transfer between guest species in small and large cages of methane + propane mixed gas hydrates.

    Science.gov (United States)

    Sugahara, Takeshi; Kobayashi, Yusuke; Tani, Atsushi; Inoue, Tatsuya; Ohgaki, Kazunari

    2012-03-15

    To investigate the molecular interaction between guest species inside of the small and large cages of methane + propane mixed gas hydrates, thermal stabilities of the methyl radical (possibly induced in small cages) and the normal propyl and isopropyl radicals (induced in large cages) were investigated by means of electron spin resonance measurements. The increase of the total amount of the normal propyl and isopropyl radicals reveals that the methyl radical in the small cage withdraws one hydrogen atom from the propane molecule enclathrated in the adjacent large cage of the structure-II hydrate. A guest species in a hydrate cage has the ability to interact closely with the other one in the adjacent cages. The clathrate hydrate may be utilized as a possible nanoscale reaction field.

  16. Use of cage molecules for cleansing and chemical analysis; Utilisations de molecules cages pour la depollution et l'analyse chimique

    Energy Technology Data Exchange (ETDEWEB)

    Janus, L.

    2003-06-15

    Cage molecules are capable to include a large variety of compounds, and to release them without any modification. This 'host'-'guest' or 'receptor'-'substrate' association concept is commonly encountered in the biological domains, and thus cage molecules can imitate a natural process. In this work 4 types of cage molecules have been used: beta-cyclo-dextrin and two of its derivatives, and tetra-pyrazole macrocycles. Polymer supports carrying these different molecules have been elaborated by different ways (grafting, polymerization, coating of a pre-existing mineral support) and have been used for two types of applications: cleansing and chiral recognition. The targeted pollutants are the toxic aromatic compounds and the heavy metals. The chiral recognition is performed by capillary electrophoresis and high-performance liquid chromatography techniques. (J.S.)

  17. Immediate placement and loading of implants in anterior maxilla using an altered screw-retained implant fixed prosthesis

    Directory of Open Access Journals (Sweden)

    Baig Mirza

    2010-01-01

    Full Text Available This article describes the immediate placement and loading of implants in the aesthetic zone using an implant-retained, fixed prosthesis with a modified design. One section of the implant prosthesis has cemented crowns and the other section is the conventional screw-retained. This combined approach significantly offsets the unsuitable implant position, alignment or angulation, while ensuring the easy retrievability, repair and maintenance of the prosthesis at the same time.

  18. Flexible and static wrist units in upper limb prosthesis users: functionality scores, user satisfaction and compensatory movements

    OpenAIRE

    Deijs, Marieke; Bongers, R.M.; Ringeling-van Leusen, N. D. M.; van der Sluis, C. K.

    2016-01-01

    Background The current study examines the relevance of prosthetic wrist movement to facilitate activities of daily living or to prevent overuse complaints. Prosthesis hands with wrist flexion/extension capabilities are commercially available, but research on the users’ experiences with flexible wrists is limited. Methods In this study, eight transradial amputees using a myoelectric prosthesis tested two prosthesis wrists with flexion/extension capabilities, the Flex-wrist (Otto Bock) and Mult...

  19. A Prosthesis to Train the Proprioceptive Capabilities of the Residual Limb of Military Personnel Recovering from Lower Limb Amputation

    Science.gov (United States)

    2012-09-01

    feedback from the ankle and foot poses challenge. To compensate for the lack of afferent feedback, amputees look down at the prosthesis to sense...10-1-0573 TITLE: A prosthesis to train the proprioceptive capabilities of the residual limb of military personnel recovering from lower limb...To) 1September2011-31August2012 4. TITLE AND SUBTITLE A Prosthesis to Train the Proprioceptive Capabilities of the 5a. CONTRACT NUMBER

  20. Courses of Action to Optimize Heavy Bearings Cages

    Science.gov (United States)

    Szekely, V. G.

    2016-11-01

    The global expansion in the industrial, economically and technological context determines the need to develop products, technologies, processes and methods which ensure increased performance, lower manufacturing costs and synchronization of the main costs reported to the elementary values which correspond to utilization”. The development trend of the heavy bearing industry and the wide use of bearings determines the necessity of choosing the most appropriate material for a given application in order to meet the cumulative requirements of durability, reliability, strength, etc. Evaluation of commonly known or new materials represents a fundamental criterion, in order to choose the materials based on the cost, machinability and the technological process. In order to ensure the most effective basis for the decision, regarding the heavy bearing cage, in the first stage the functions of the product are established and in a further step a comparative analysis of the materials is made in order to establish the best materials which satisfy the product functions. The decision for selecting the most appropriate material is based largely on the overlapping of the material costs and manufacturing process during which the half-finished material becomes a finished product. The study is orientated towards a creative approach, especially towards innovation and reengineering by using specific techniques and methods applied in inventics. The main target is to find new efficient and reliable constructive and/or technological solutions which are consistent with the concept of sustainable development.