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Sample records for caesalpinioideae structural aspects

  1. Ontogenesis, structure and ultrastructure of Hymenaea stigonocarpa (Fabaceae: Caesalpinioideae colleters

    Directory of Open Access Journals (Sweden)

    Élder Antônio Sousa Paiva

    2006-09-01

    Full Text Available The genus Hymenaea is characterized by a great diversity of secretory structures, but there are no reports of colleters yet. The objectives of this study are to report the occurrence and describe the origin and structure of colleters in Hymenaea stigonocarpa Mart. ex Hayne. Shoot apex samples were collected, fixed, and processed for light microscopy, scanning electron microscopy, and transmission electron microscopy as per usual methods. Colleters occur predominantly on the stipule’s adaxial side. These structures are found at the base on a narrow strip, corresponding to the median vein up to half the length of the stipule. When present on the abaxial side, they are concentrated at the base and restricted to the margins. Colleters develop from the protoderm; they are elongate and club-shaped. Their body has no stratification; their surface cells differ from the inner cells only in position and presence of cuticle. Colleter cells have thin walls, dense cytoplasm, large nuclei, many mitochondria, rough endoplasmic reticulum, and abundant dictyosomes. Histochemical tests with Ruthenium red showed pectic compounds in the cytosol. In H. stigonocarpa, colleter arrangement is compatible with the hypothesis that they protect shoot apex. In this species, protection is reinforced by the sheath formed by the stipule pairs. Rev. Biol. Trop. 54 (3: 943-950. Epub 2006 Sept. 29.El género Hymenaea se caracteriza por una gran diversidad de estructuras secretoras, pero no hay informes de coléteres. El objetivo de este estudio es informar de su existencia en el género, y describir el origen y estructura de los coléteres en Hymenaea stigonocarpa Mart. ex Hayne. Procesamos muestras del ápice de brotes según los métodos generales para microscopio óptico, microscopio electrónico de barrido y microscopio electrónico de transmisión. Los coléteres están predominantemente en la parte adaxial de las estípulas, ocupando la base en una estrecha franja desde

  2. Chemical constituents of the flowers of Pterogyne nitens (caesalpinioideae); Constituintes quimicos das flores Pterogyne nitens (caesalpinioideae)

    Energy Technology Data Exchange (ETDEWEB)

    Regasini, Luis Octavio; Fernandes, Daniara Cristina; Castro-Gamboa, Ian; Silva, Dulce Helena Siqueira; Furlan, Maysa; Bolzani, Vanderlan da Silva [Universidade Estadual Paulista (UNESP), Araraquara, SP (Brazil). Inst. de Quimica. Dept. de Quimica Organica]. E-mail: bolzaniv@iq.unesp.br; Barreiro, Eliezer Jesus [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Faculdade de Farmacia. Centro de Ciencias da Saude; Cardoso-Lopes, Elaine Monteiro; Young, Maria Claudia Marx; Torres, Luce Brandao [Instituto de Botanica, Sao Paulo, SP (Brazil). Secao de Fisiologia e Bioquimica de Plantas; Vellosa, Jose Carlos Rebuglio; Oliveira, Olga Maria Mascarenhas de [Universidade Estadual Paulista (UNESP), Araraquara, SP (Brazil). Inst. de Quimica. Dept. de Quimica e Tecnologia

    2008-07-01

    The phytochemical investigation of the flowers of Pterogyne nitens (Caesalpinioideae) resulted in the isolation and identification of nine phenolic derivatives, quercetin 3-O-sophoroside, taxifolin, astilbin, ourateacatechin, caffeic, ferulic, sinapic, chlorogenic and gallic acid, besides two guanidine alkaloids, pterogynine, pterogynidine. This is the first time these compounds have been reported in P. nitens flowers. As this is a monospecific genus, these secondary metabolites may have taxonomical significance. Their structures were assigned on the basis of spectroscopic analyses, including two-dimensional NMR techniques. (author)

  3. Constituintes químicos das flores de Pterogyne nitens (Caesalpinioideae Chemical constituents of the flowers of Pterogyne nitens (caesalpinioideae

    Directory of Open Access Journals (Sweden)

    Luis Octávio Regasini

    2008-01-01

    Full Text Available The phytochemical investigation of the flowers of Pterogyne nitens (Caesalpinioideae resulted in the isolation and identification of nine phenolic derivatives, quercetin 3-O-sophoroside, taxifolin, astilbin, ourateacatechin, caffeic, ferulic, sinapic, chlorogenic and gallic acid, besides two guanidine alkaloids, pterogynine, pterogynidine. This is the first time these compounds have been reported in P. nitens flowers. As this is a monospecific genus, these secondary metabolites may have taxonomical significance. Their structures were assigned on the basis of spectroscopic analyses, including two-dimensional NMR techniques.

  4. Aspects of hadronic structure

    International Nuclear Information System (INIS)

    Ferreira, P.L.

    1984-01-01

    An overview of the current phenomenological models of hadron structure, whose theoretical basis is the Quantum Chromodynamics (QCD), is presented. A short introduction to the QCD permits to focalize the relevant properties which are attached to those models. Following, bag-like models (in particular, MIT bag and chiral extensions) and potential-like models among them the Karl and Isgur non-relativistic model and a semi-relativistic model, free of the Klein paradox, with equal scalar-vetorial mixture of confinement potential are shortly studied. Enphasis is given to the baryons, treated, basically, as three-quarks systems. (L.C.) [pt

  5. Phylogeographical structure of the neotropical forest tree Hymenaea courbaril (Leguminosae: Caesalpinioideae) and its relationship with the Vicariant Hymenaea stigonocarpa from Cerrado.

    Science.gov (United States)

    Ramos, Ana Carolina Simões; De Lemos-Filho, José Pires; Lovato, Maria Bernadete

    2009-01-01

    The phylogeography of Hymenaea courbaril var. stilbocarpa from Atlantic Forest and riverine forests of the Cerrado biome in central and southeastern Brazil was investigated. The data were compared with those of its congeneric Hymenaea stigonocarpa, a typical tree from savanna. In the Cerrado, H. courbaril var. stilbocarpa is found in sites contiguous with those of H. stigonocarpa, and they share common life-history attributes. The psbC/trnS3 region of the chloroplast DNA was sequenced in 149 individuals of H. courbaril var. stilbocarpa. High genetic variation was found in this species, with the identification of 18 haplotypes, similarly to what was found in H. stigonocarpa with 23 haplotypes in the same geographic region. Populations of H. courbaril var. stilbocarpa could be structured in 3 phylogeographic groups. Spatial analysis of molecular variation indicated that 46.4% of the genetic variation was due to differences among these groups. Three haplotypes were shared by H. courbaril var. stilbocarpa and H. stigonocarpa, and only 10.5% of the total genetic variation could be attributed to between-species difference. We surmise that during the glacial times, H. courbaril var. stilbocarpa populations must have gone extinct in most parts of the southern of its present-day occurrence area. After climate amelioration, these areas were probably recolonized from northern and eastern. The relatively similar phylogeographic structure of vicariant Hymenaea species suggests that they were subjected to the same impacts during the Quaternary climatic fluctuations. The sharing of haplotypes and the genetic similarity between the 2 Hymenaea species suggest the existence of ancestral polymorphism and/or hybridization.

  6. Wood anatomy of tribe Detarieae and comparison with tribe Caesalpinieae (Leguminosae, Caesalpinioideae) in Venezuela.

    Science.gov (United States)

    Melandri, José Luis; de Pernía, Narcisana Espinoza

    2009-01-01

    We studied the wood anatomy of 29 species belonging to 10 genera of the tribe Detarieae, subfamily Caesalpinioideae and compare them with tribe Caesalpinieae. Detarieae is the largest of four tribes of Caesalpinioideae, with 84 genera, only eleven occur in Venezuela with species of timber importance. The specimens were collected in Venezuela and include wood samples from the collection of the Laboratorio de Anatomía de Maderas de la Facultad de Ciencias Forestales y Ambientales de la Universidad de Los Andes, Venezuela, and of the Forest Products Laboratory of the USDA Forest Service in Madison, Wisconsin, USA. The terminology and methodology used followed the IAWA List of Microscopic Features for Hardwood Identification of the IAWA Committee, 1989. Measurements from each specimen were averaged (vessel diameters, vessel element lengths, intervessels pit size, fibre lengths and ray height). The species of Detarieae can be separated using a combination of diagnostic features. Wood characters that provide the most important diagnosis and may be used in systematics of Detarieae include: intercellular axial canals, rays heterocellular, rays exclusively or predominantly uniseriate, prismatic crystals common in ray cells, irregular storied structure and fibre wall thickness. For comparative anatomy between Detarieae and Caesalpinieae: intercellular axial canals, heterocellular rays, rays exclusively or predominantly uniseriate, prismatic crystals common in ray cells (in Detarieae) and regular storied structure, fibres septate, fibre wall thick or very thick, rays homocellular, multiseriate rays and silica bodies (in Caesalpinieae). Axial parenchyma is typically a good diagnostic feature for Leguminosae, but not for Detarieae and Caesalpinieae comparisons.

  7. Mechanical aspects of VIVITRON: the structure

    International Nuclear Information System (INIS)

    Gaudiot, G.; Koenig, R.; Cherrier, G.; Esteve, T.; Peter, R.

    1987-11-01

    The main aspects of the VIVITRON mechanical structure are discussed through a description of the tank and the internal structure. The results of the calculated constraints on the structure are presented [fr

  8. Statistical aspects of nuclear structure

    International Nuclear Information System (INIS)

    Parikh, J.C.

    1977-01-01

    The statistical properties of energy levels and a statistical approach to transition strengths are discussed in relation to nuclear structure studies at high excitation energies. It is shown that the calculations can be extended to the ground state domain also. The discussion is based on the study of random matrix theory of level density and level spacings, using the Gaussian Orthogonal Ensemble (GOE) concept. The short range and long range correlations are also studied statistically. The polynomial expansion method is used to obtain excitation strengths. (A.K.)

  9. O gênero bauhinia l. (caesalpinioideae - leguminosae) no estado de Mato Grosso do Sul, Brasil

    OpenAIRE

    Silva, Geciani Miriam

    2008-01-01

    (O gênero Bauhinia L. (Caesalpinioideae - Leguminosae) no estado de Mato Grosso do Sul, Brasil) - Bauhinia sensu stricto (Caesalpinioideae - Leguminosae) é um gênero pantropical com cerca de 150 espécies. Este trabalho consiste no levantamento de representantes de Bauhinia s. s. ocorrentes no estado de Mato Grosso do Sul. Para tanto, foram analisados espécimes herborizados provenientes de acervos regionais e nacionais e de coletas realizadas em diferentes regiões do Estado. É confirmada a oco...

  10. Structural aspects of some hydrobenzofuran neolignans

    International Nuclear Information System (INIS)

    Yoshida, Massayoshi

    2012-01-01

    The neolignans are defined as dimers of allylphenol and propenylphenol between itself or crossed, whose bond does not occur by the 8-8' carbons like lignans. This review centered on stereochemical aspects of the hydrobenzofuran type, a widespread skeleton among neolignans. The chemical structures established based on spectrometric data are registered in the literature. The absolute configurations reported previously were determined by chiroptical techniques. Some chemical transformations with neolignans, performed in previous studies, afforded products which are accumulated in other vegetal species and contributed to assign the unknown stereochemistry of these natural compounds. Possible biosynthetic pathways are also proposed. (author)

  11. Exotic nuclei: another aspect of nuclear structure

    International Nuclear Information System (INIS)

    Dobaczewski, J.; Blumenfeld, Y.; Flocard, H.; Garcia Borge, M.J.; Nowacki, F.; Rombouts, S.; Theisen, Ch.; Marques, F.M.; Lacroix, D.; Dessagne, P.; Gaeggeler, H.

    2002-01-01

    This document gathers the lectures made at the Joliot Curie international summer school in 2002 whose theme that year was exotic nuclei. There were 11 contributions whose titles are: 1) interactions, symmetry breaking and effective fields from quarks to nuclei; 2) status and perspectives for the study of exotic nuclei: experimental aspects; 3) the pairing interaction and the N = Z nuclei; 4) borders of stability region and exotic decays; 5) shell structure of nuclei: from stability to decay; 6) variational approach of system with a few nucleons; 7) from heavy to super-heavy nuclei; 8) halos, molecules and multi-neutrons; 9) macroscopic approaches for fusion reactions; 10) beta decay: a tool for spectroscopy; 11) the gas phase chemistry of super-heavy elements

  12. Gauge field vacuum structure in geometrical aspect

    International Nuclear Information System (INIS)

    Konopleva, N.P.

    2003-01-01

    Vacuum conception is one of the main conceptions of quantum field theory. Its meaning in classical field theory is also very profound. In this case the vacuum conception is closely connected with ideas of the space-time geometry. The global and local geometrical space-time conceptions lead to different vacuum definitions and therefore to different ways of physical theory construction. Some aspects of the gauge field vacuum structure are analyzed. It is shown that in the gauge field theory the vacuum Einstein equation solutions describe the relativistic vacuum as common vacuum of all gauge fields and its sources. Instantons (both usual and hyperbolical) are regarded as nongravitating matter, because they have zero energy-momentum tensors and correspond to vacuum Einstein equations

  13. Morphological analyses suggest a new taxonomic circumscription for Hymenaea courbaril L. (Leguminosae, Caesalpinioideae)

    OpenAIRE

    Souza,Isys; Funch ,Ligia; de Queiroz,Luciano

    2014-01-01

    Abstract Hymenaea is a genus of the Resin-producing Clade of the tribe Detarieae (Leguminosae: Caesalpinioideae) with 14 species. Hymenaea courbaril is the most widespread species of the genus, ranging from southern Mexico to southeastern Brazil. As currently circumscribed, Hymenaea courbaril is a polytypic species with six varieties: var. altissima, var. courbaril, var. longifolia, var. stilbocarpa, var. subsessilis, and var. villosa. These varieties are distinguishable mostly by traits rela...

  14. Structural aspects of high temperature superconductors

    International Nuclear Information System (INIS)

    Sequeira, A.

    1991-01-01

    This paper reports that the general structure of HTSC is known to be perovskite related involving layered stacking of perovskite and rock-salt like slabs with a specific sequence for a given type of structure. The prototype structures of various type of HTSC are now well established. Their detailed structural parameters are well documented. It is clear from that the number of oxygen atoms present in many of these structures is different from, and generally much less than, the number of anionic sites available. If the number of oxygens are in excess, they could of course occupy the interstitial sites. For example, in pure oxygen La 2 CuO 4+δ , the excess oxygen has been shown to go into interstitial sites. Although the prototypic structures of all HTSC are well established, their actual structures can have significant variations from the prototypes. In fact, their real structures are not yet fully known. Being nonstoichiometric, they are essentially metastable, entropy stabilized structures which exhibit wide compositional fluctuations and oxygen disorder effects. Their superconducting properties are known to be sensitive to their oxygen content and according to some theories the mechanism of superconductivity is presumably related to the oxygen defects or defectons. Neutron diffraction happens to be the method of choice for probing detailed structural features involving oxygen defects and associated distortions which are known to play a significant role on the properties of HTSC

  15. Structural integrity aspects of reactor safety

    Indian Academy of Sciences (India)

    This is assessed by applying fracture mechanics principles. A number of methods are available to assess the integrity of flawed structures. The failure criterion in most of these methods is either fracture based or is plastic instability based. In order to ascertain the integrity of a flawed structure one has to perform two analyses, ...

  16. Structural aspects of the Chernobyl accident

    International Nuclear Information System (INIS)

    Murray, R.C.; Cummings, G.E.

    1988-01-01

    On April 26, 1986 the world's worst nuclear power plant accident occurred at the Unit 4 of the Chernobyl Nuclear Power Station in the USSR. This paper presents a discussion of the design of the Chernobyl Power Plant, the sequence of events that led to the accident and the damage caused by the resulting explosion. The structural design features that contributed to the accident and resulting damage will be highlighted. Photographs and sketches obtained from various worldwide news agencies will be shown to try and gain a perspective of the extent of the damage. The aftermath, clean-up, and current situation will be discussed and the important lessons learned for the structural engineer will be presented. 15 refs., 10 figs

  17. Structural aspects of asymptotically safe black holes

    Science.gov (United States)

    Koch, Benjamin; Saueressig, Frank

    2014-01-01

    We study the quantum modifications of classical, spherically symmetric Schwarzschild (anti-) de Sitter black holes within quantum Einstein gravity. The quantum effects are incorporated through the running coupling constants Gk and Λk, computed within the exact renormalization group approach, and a common scale-setting procedure. We find that, in contrast to common intuition, it is actually the cosmological constant that determines the short-distance structure of the RG-improved black hole: in the asymptotic UV the structure of the quantum solutions is universal and given by the classical Schwarzschild-de Sitter solution, entailing a self-similarity between the classical and quantum regime. As a consequence asymptotically safe black holes evaporate completely and no Planck-size remnants are formed. Moreover, the thermodynamic entropy of the critical Nariai black hole is shown to agree with the microstate count based on the effective average action, suggesting that the entropy originates from quantum fluctuations around the mean-field geometry.

  18. Towards aspect-oriented functional--structural plant modelling.

    Science.gov (United States)

    Cieslak, Mikolaj; Seleznyova, Alla N; Prusinkiewicz, Przemyslaw; Hanan, Jim

    2011-10-01

    Functional-structural plant models (FSPMs) are used to integrate knowledge and test hypotheses of plant behaviour, and to aid in the development of decision support systems. A significant amount of effort is being put into providing a sound methodology for building them. Standard techniques, such as procedural or object-oriented programming, are not suited for clearly separating aspects of plant function that criss-cross between different components of plant structure, which makes it difficult to reuse and share their implementations. The aim of this paper is to present an aspect-oriented programming approach that helps to overcome this difficulty. The L-system-based plant modelling language L+C was used to develop an aspect-oriented approach to plant modelling based on multi-modules. Each element of the plant structure was represented by a sequence of L-system modules (rather than a single module), with each module representing an aspect of the element's function. Separate sets of productions were used for modelling each aspect, with context-sensitive rules facilitated by local lists of modules to consider/ignore. Aspect weaving or communication between aspects was made possible through the use of pseudo-L-systems, where the strict-predecessor of a production rule was specified as a multi-module. The new approach was used to integrate previously modelled aspects of carbon dynamics, apical dominance and biomechanics with a model of a developing kiwifruit shoot. These aspects were specified independently and their implementation was based on source code provided by the original authors without major changes. This new aspect-oriented approach to plant modelling is well suited for studying complex phenomena in plant science, because it can be used to integrate separate models of individual aspects of plant development and function, both previously constructed and new, into clearly organized, comprehensive FSPMs. In a future work, this approach could be further

  19. ASPECTS REGARDING THE STRUCTURE OF GRADUATION PAPERS IN INDUSTRIAL DESIGN

    Directory of Open Access Journals (Sweden)

    BOLOŞ Codruţa

    2008-07-01

    Full Text Available The paper presents aspects regarding the structure, themes and content of graduation papers in the specialization of Industrial Design within Petru Maior University of Târgu Mures.

  20. Structural aspects of Imbrium sculpture, part G

    Science.gov (United States)

    Scott, D. H.

    1972-01-01

    Apollo 16 metric photographs taken at low to high sun angles provided the first stereographic coverage of the distinctive landforms collectively referred to as Imbrium sculpture. The sculpture consists of a series of nearly linear ridges and troughs extending radially outward for more than 1000 km from the rim of the Imbrium Basin. The origin of the ridges and troughs, whether by deposition and impact scoring by fluidized clouds of ejecta from the Imbrium Basin or by faulting and volcanism during and subsequent to basin formation, is controversial. Evidence indicative of the mode of origin of Imbrium sculpture is summarized as follows. Evidence of volcano-tectonic mode of origin is favored by: (1) wide variation in relative age of parts of the sculpture; (2) furrows without rims; (3) absence of ballistic shielding; (4) asymmetry of sculpture; (5) absence of randomly oriented clusters; and (6) association with other features of structural origin. An origin by ejecta scoring and deposition is favored by the gradational ejecta with a Fra Mauro-type texture. Features that are ambiguous as to mode or origin are furrows made of coalesced crater chains and prominent rims on furrows.

  1. Conjugated Polymers and Oligomers: Structural and Soft Matter Aspects

    DEFF Research Database (Denmark)

    This book identifies modern topics and current trends of structural and soft matter aspects of conjugated polymers and oligomers. Each chapter recognizes an active research line where structural perspective dominates research and therefore the book covers fundamental aspects of persistent...... conjugated polymer backbone, water soluble conjugated polyelectrolytes and surfactants, conjugated molecules and biomolecules and DNA and the advanced use of synchrotron radiation and electron microscopy to find out structural details in conjugated molecule films and devices as well as under ambient...... and extreme conditions....

  2. Thermodynamic, kinetic and electronic structure aspects of a charge ...

    Indian Academy of Sciences (India)

    Thermodynamic, kinetic and electronic structure aspects of a charge-transfer active bichromophoric organofullerene. K SENTHIL KUMAR and ARCHITA PATNAIK. ∗. Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, India e-mail: archita59@yahoo.com. MS received 11 January 2012; ...

  3. High aspect ratio titanium nitride trench structures as plasmonic biosensor

    DEFF Research Database (Denmark)

    Shkondin, Evgeniy; Repän, Taavi; Takayama, Osamu

    2017-01-01

    High aspect ratio titanium nitride (TiN) grating structures are fabricated by the combination of deep reactive ion etching (DRIE) and atomic layer deposition (ALD) techniques. TiN is deposited at 500 ◦C on a silicon trench template. Silicon between vertical TiN layers is selectively etched...

  4. Fragile yet Ductile : Structural Aspects of Reinforced Glass Beams

    NARCIS (Netherlands)

    Louter, P.C.

    2011-01-01

    This dissertation investigates the structural aspects of reinforced glass beams. The concept of these beams, which are intended for building applications, is to provide redundancy even if the glass is broken. This redundancy is obtained through a small reinforcement section that is bonded at the

  5. Aspects of population structure of Parechinus angulosus Leske ...

    African Journals Online (AJOL)

    Aspects of population structure of Parechinus angulosus Leske, around the Cape Peninsula. A.H. Fricke ... cularly in view of the severe impact on kelp beds in Cali- fornia and on the east coast of Canada by ..... (Fig. 5). Food resources for the early stages of Parechinus are most plentiful in an upwelling area such as ...

  6. The Large Scale Structure: Polarization Aspects R. F. Pizzo

    Indian Academy of Sciences (India)

    c Indian Academy of Sciences. The Large Scale Structure: Polarization Aspects. R. F. Pizzo. ASTRON, Postbus 2, 7990 AA Dwingeloo, The Netherlands e-mail: pizzo@astron.nl. Abstract. Polarized radio emission is detected at various scales in the. Universe. In this document, I will briefly review our knowledge on polar-.

  7. Structural analysis of a ship on global aspect using ANSYS

    Science.gov (United States)

    Rahman, M. Muzibur; Kamol, Rajia Sultana; Islam, Reyana

    2017-12-01

    Ship is a complex geometry which undergoes a combination of loadings such as hydrostatic, hydrodynamic, wind, wave etc. at sea and thus adequate strength in a ship has always been one of the most challenging tasks for the ship designers. International Maritime Organization (IMO) and classification societies are providing the standards to ensure the adequacy of strength for the ship against all demands throughout its service life. Thus, structural analysis is needed to assess the overall strength of hull, and the means in this regard are based on finite element method which may be applied either local or global aspect of the ship. This paper is an attempt to carry out the structural analysis of a ship in global aspect using ANSYS software to locate the most stress concentration and deformed area, which will have ultimate effect on fatigue fracture.

  8. Filogeografía del complejo Caesalpinia hintonii: (Leguminosae: Caesalpinioideae: Poincianella Phylogeography of the Caesalpinia hintonii complex (Leguminosae: Caesalpinioideae: Poincianella

    Directory of Open Access Journals (Sweden)

    Solange Sotuyo

    2010-12-01

    Full Text Available A pesar del crecido número de estudios que se ha realizado para explorar la estructura genética y filogeográfica en especies mexicanas, hay carencia de estudios para especies de selva baja, zonas con alto grado de endemismo. Para un mejor entendimiento de dichas áreas se realizó un estudio filogeográfico y el fechamiento de las especies del complejo Caesalpinia hintonii distribuido en la depresión del río Balsas y el valle de Tehuacán-Cuicatlán. Se determinó la estructura filogeográfica del complejo analizando las secuencias de 4 regiones de plastidio (intrón trnL, espaciador trnL-F, espaciador psbA-trnH y espaciador accD-psaI en todas las poblaciones disponibles. Se estimó la fecha del origen del complejo mediante un método no paramétrico (NPRS. Las diversidades haplotídicas (0.64-1 y las diferencias nucleotídicas (3.8-11.52 en todas las especies fueron altas respecto a valores registrados para otras plantas. Las poblaciones de C. oyamae, morfológicamente indistintas están genéticamente estructuradas y presentan 3 haplogrupos donde el flujo génico entre ellos es bajo y se consideraron entidades crípticas. Las poblaciones de C. hintonii son un grupo genéticamente homogéneo a pesar de ser morfológicamente distintas. Las poblaciones de C. macvaughii forman 2 linajes divergentes entre los que existe flujo génico (Nm=1.41. Los eventos de divergencia en 2 grandes linajes al este y oeste del río Balsas pueden explicarse por eventos geológicos. Los resultados indican que el complejo se encuentra bajo divergencia y en algunos casos radiación morfostática.Although many phylogeographic studies have been conducted to analyze the genetic and phylogeographic structure of Mexican species, such studies are nearly absent for plants of dry seasonal forest, precincts with high level of endemism. To better understand this areas, we undertook a phylogeographic study and dating were carried out on the Caesalpinia hintonii complex

  9. Selected Aspects of Computer Modeling of Reinforced Concrete Structures

    Directory of Open Access Journals (Sweden)

    Szczecina M.

    2016-03-01

    Full Text Available The paper presents some important aspects concerning material constants of concrete and stages of modeling of reinforced concrete structures. The problems taken into account are: a choice of proper material model for concrete, establishing of compressive and tensile behavior of concrete and establishing the values of dilation angle, fracture energy and relaxation time for concrete. Proper values of material constants are fixed in simple compression and tension tests. The effectiveness and correctness of applied model is checked on the example of reinforced concrete frame corners under opening bending moment. Calculations are performed in Abaqus software using Concrete Damaged Plasticity model of concrete.

  10. Morphological analyses suggest a new taxonomic circumscription for Hymenaea courbaril L. (Leguminosae, Caesalpinioideae

    Directory of Open Access Journals (Sweden)

    Isys Souza

    2014-06-01

    Full Text Available Hymenaea is a genus of the Resin-producing Clade of the tribe Detarieae (Leguminosae: Caesalpinioideae with 14 species. Hymenaea courbaril is the most widespread species of the genus, ranging from southern Mexico to southeastern Brazil. As currently circumscribed, H. courbaril is a polytypic species with six varieties: var. altissima, var. courbaril, var. longifolia, var. stilbocarpa, var. subsessilis, and var. villosa. These varieties are distinguishable mostly by traits related to leaflet shape and indumentation, and calyx indumentation. We carried out morphometric analyses of 14 quantitative (continuous leaf characters in order to assess the taxonomy of H. courbaril under the Unified Species Concept framework. Cluster analysis used the Unweighted Pair Group Method with Arithmetic Mean (UPGMA based on Bray-Curtis dissimilarity matrices. Principal Component Analyses (PCA were carried out based on the same morphometric matrix. Two sets of Analyses of Similarity and Non Parametric Multivariate Analysis of Variance were carried out to evaluate statistical support (1 for the major groups recovered using UPGMA and PCA, and (2 for the varieties. All analyses recovered three major groups coincident with (1 var. altissima, (2 var. longifolia, and (3 all other varieties. These results, together with geographical and habitat information, were taken as evidence of three separate metapopulation lineages recognized here as three distinct species. Nomenclatural adjustments, including reclassifying formerly misapplied types, are proposed.

  11. Morphological analyses suggest a new taxonomic circumscription for Hymenaea courbaril L. (Leguminosae, Caesalpinioideae).

    Science.gov (United States)

    Souza, Isys Mascarenhas; Funch, Ligia Silveira; de Queiroz, Luciano Paganucci

    2014-01-01

    Hymenaea is a genus of the Resin-producing Clade of the tribe Detarieae (Leguminosae: Caesalpinioideae) with 14 species. Hymenaea courbaril is the most widespread species of the genus, ranging from southern Mexico to southeastern Brazil. As currently circumscribed, Hymenaea courbaril is a polytypic species with six varieties: var. altissima, var. courbaril, var. longifolia, var. stilbocarpa, var. subsessilis, and var. villosa. These varieties are distinguishable mostly by traits related to leaflet shape and indumentation, and calyx indumentation. We carried out morphometric analyses of 14 quantitative (continuous) leaf characters in order to assess the taxonomy of Hymenaea courbaril under the Unified Species Concept framework. Cluster analysis used the Unweighted Pair Group Method with Arithmetic Mean (UPGMA) based on Bray-Curtis dissimilarity matrices. Principal Component Analyses (PCA) were carried out based on the same morphometric matrix. Two sets of Analyses of Similarity and Non Parametric Multivariate Analysis of Variance were carried out to evaluate statistical support (1) for the major groups recovered using UPGMA and PCA, and (2) for the varieties. All analyses recovered three major groups coincident with (1) var. altissima, (2) var. longifolia, and (3) all other varieties. These results, together with geographical and habitat information, were taken as evidence of three separate metapopulation lineages recognized here as three distinct species. Nomenclatural adjustments, including reclassifying formerly misapplied types, are proposed.

  12. Structural Aspects of GPCR-G Protein Coupling.

    Science.gov (United States)

    Chung, Ka Young

    2013-09-01

    G protein-coupled receptors (GPCRs) are membrane receptors; approximately 40% of drugs on the market target GPCRs. A precise understanding of the activation mechanism of GPCRs would facilitate the development of more effective and less toxic drugs. Heterotrimeric G proteins are important molecular switches in GPCR-mediated signal transduction. An agonist-activated receptor interacts with specific sites on G proteins and promotes the release of GDP from the Gα subunit. Because of the important biological role of the GPCR-G protein coupling, conformational changes in the G protein upon receptor coupling have been of great interest. One of the most important questions was the interface between the GPCR and G proteins and the structural mechanism of GPCR-induced G protein activation. A number of biochemical and biophysical studies have been performed since the late 80s to address these questions; there was a significant breakthrough in 2011 when the crystal structure of a GPCR-G protein complex was solved. This review discusses the structural aspects of GPCR-G protein coupling by comparing the results of previous biochemical and biophysical studies to the GPCR-G protein crystal structure.

  13. Power system damping - Structural aspects of controlling active power

    Energy Technology Data Exchange (ETDEWEB)

    Samuelsson, O.

    1997-04-01

    Environmental and economical aspects make it difficult to build new power lines and to reinforce existing ones. The continued growth in demand for electric power must therefore to a great extent be met by increased loading of available lines. A consequence is that power system damping is reduced, leading to a risk of poorly damped power oscillations between the generators. This thesis proposes the use of controlled active loads to increase damping of such electro-mechanical oscillations. The focus is on structural aspects of controller interaction and of sensor and actuator placement. On-off control based on machine frequency in a single machine infinite bus system is analysed using energy function analysis and phase plane plots. An on-off controller with estimated machine frequency as input has been implemented. At a field test it damped oscillations of a 0.9 MW hydro power generator by controlling a 20kW load. The linear analysis uses two power system models with three and twenty-three machines respectively. Each damper has active power as output and local bus frequency or machine frequency as input. The power system simulator EUROSTAG is used both for generation of the linearized models and for time simulations. Measures of active power mode controllability and phase angle mode observability are obtained from the eigenvectors of the differential-algebraic models. The geographical variation in the network of these quantities is illustrated using the resemblance to bending modes of flexible mechanical structures. Eigenvalue sensitivities are used to determine suitable damper locations. A spring-mass equivalent to an inter-area mode provides analytical expressions, that together with the concept of impedance matching explain the structural behaviour of the power systems. For large gains this is investigated using root locus plots. 64 refs, 99 figs, 20 tabs

  14. KEY ASPECTS OF ENSURING ENERGY EFFICIENCY OF BUILDINGS AND STRUCTURES

    Directory of Open Access Journals (Sweden)

    S.G. Abramyan

    2017-06-01

    Full Text Available The paper is based on the review of the foreign and national academic literature and intended to emphasize the issues of ensuring energy efficiency of buildings and structures applicable to all the countries as for reconstruction of existing buildings as for erection of new ones . The author highlights the key aspects of the provision of energy efficiency of buildings and structures in some foreign countries. The conclusion is made that the studies are mainly aimed at discovering new heat insulation materials, whereby polystyrene insulation is found to be the most widespread wall insulation material in a number of countries. At the same time, it is observed that the ongoing research is focused on solutions to optimize the structure of walling systems in terms of both insulant thickness and the number and sequence of insulation layers in the walling structure. A conclusion is made that hyper insulation of external walls leads to considerable expenses arising due to cooling during the summer season. The use of prefabricated vacuum panels as a heat insulation layer and off-the-shelf single-layer structures, subject to their heat insulation characteristics, appears a more constructive way to meet the energy efficiency requirements, as the arrangement of ideal air space in multilayered walls proves a significant challenge today. One of the most promising ways to ensure energy efficiency is the use of multifunctional polyvalent walls and provision of polyvalent heat supply from renewable energy sources. Since energy efficiency depends on the spatial arrangement of buildings, construction must ensure a minimum ratio of the area of enclosing structures to the overall building volume (by adding on new facilities in case of reconstruction. It is noted that a systemic approach to ensuring energy efficiency of buildings is impossible without proper regard to the environmental parameters of heat insulation materials.

  15. Nodulation in Dimorphandra wilsonii Rizz. (Caesalpinioideae), a Threatened Species Native to the Brazilian Cerrado

    Science.gov (United States)

    Fonseca, Márcia Bacelar; Peix, Alvaro; de Faria, Sergio Miana; Mateos, Pedro F.; Rivera, Lina P.; Simões-Araujo, Jean L.; França, Marcel Giovanni Costa; dos Santos Isaias, Rosy Mary; Cruz, Cristina; Velázquez, Encarna; Scotti, Maria Rita; Sprent, Janet I.; James, Euan K.

    2012-01-01

    The threatened caesalpinioid legume Dimorphandra wilsonii, which is native to the Cerrado biome in Brazil, was examined for its nodulation and N2-fixing ability, and was compared with another, less-threatened species, D. jorgei. Nodulation and potential N2 fixation was shown on seedlings that had been inoculated singly with five bradyrhizobial isolates from mature D. wilsonii nodules. The infection of D. wilsonii by two of these strains (Dw10.1, Dw12.5) was followed in detail using light and transmission electron microscopy, and was compared with that of D. jorgei by Bradyrhizobium strain SEMIA6099. The roots of D. wilsonii were infected via small transient root hairs at 42 d after inoculation (dai), and nodules were sufficiently mature at 63 dai to express nitrogenase protein. Similar infection and nodule developmental processes were observed in D. jorgei. The bacteroids in mature Dimorphandra nodules were enclosed in plant cell wall material containing a homogalacturonan (pectic) epitope that was recognized by the monoclonal antibody JIM5. Analysis of sequences of their rrs (16S rRNA) genes and their ITS regions showed that the five D. wilsonii strains, although related to SEMIA6099, may constitute five undescribed species of genus Bradyrhizobium, whilst their nodD and nifH gene sequences showed that they formed clearly separated branches from other rhizobial strains. This is the first study to describe in full the N2-fixing symbiotic interaction between defined rhizobial strains and legumes in the sub-family Caesalpinioideae. This information will hopefully assist in the conservation of the threatened species D. wilsonii. PMID:23185349

  16. Structural and degradative aspects of ornithine decarboxylase antizyme inhibitor 2

    Directory of Open Access Journals (Sweden)

    Bruno Ramos-Molina

    2014-01-01

    Full Text Available Ornithine decarboxylase (ODC is the key enzyme in the polyamine biosynthetic pathway. ODC levels are controlled by polyamines through the induction of antizymes (AZs, small proteins that inhibit ODC and target it to proteasomal degradation without ubiquitination. Antizyme inhibitors (AZIN1 and AZIN2 are proteins homologous to ODC that bind to AZs and counteract their negative effect on ODC. Whereas ODC and AZIN1 are well-characterized proteins, little is known on the structure and stability of AZIN2, the lastly discovered member of this regulatory circuit. In this work we first analyzed structural aspects of AZIN2 by combining biochemical and computational approaches. We demonstrated that AZIN2, in contrast to ODC, does not form homodimers, although the predicted tertiary structure of the AZIN2 monomer was similar to that of ODC. Furthermore, we identified conserved residues in the antizyme-binding element, whose substitution drastically affected the capacity of AZIN2 to bind AZ1. On the other hand, we also found that AZIN2 is much more labile than ODC, but it is highly stabilized by its binding to AZs. Interestingly, the administration of the proteasome inhibitor MG132 caused differential effects on the three AZ-binding proteins, having no effect on ODC, preventing the degradation of AZIN1, but unexpectedly increasing the degradation of AZIN2. Inhibitors of the lysosomal function partially prevented the effect of MG132 on AZIN2. These results suggest that the degradation of AZIN2 could be also mediated by an alternative route to that of proteasome. These findings provide new relevant information on this unique regulatory mechanism of polyamine metabolism.

  17. Structural aspects of Lorentz-violating quantum field theory

    Science.gov (United States)

    Cambiaso, M.; Lehnert, R.; Potting, R.

    2018-01-01

    In the last couple of decades the Standard Model Extension has emerged as a fruitful framework to analyze the empirical and theoretical extent of the validity of cornerstones of modern particle physics, namely, of Special Relativity and of the discrete symmetries C, P and T (or some combinations of these). The Standard Model Extension allows to contrast high-precision experimental tests with posited alterations representing minute Lorentz and/or CPT violations. To date no violation of these symmetry principles has been observed in experiments, mostly prompted by the Standard-Model Extension. From the latter, bounds on the extent of departures from Lorentz and CPT symmetries can be obtained with ever increasing accuracy. These analyses have been mostly focused on tree-level processes. In this presentation I would like to comment on structural aspects of perturbative Lorentz violating quantum field theory. I will show that some insight coming from radiative corrections demands a careful reassessment of perturbation theory. Specifically I will argue that both the standard renormalization procedure as well as the Lehmann-Symanzik-Zimmermann reduction formalism need to be adapted given that the asymptotic single-particle states can receive quantum corrections from Lorentz-violating operators that are not present in the original Lagrangian.

  18. Astaxanthin: structural and functional aspects Astaxantina: aspectos estruturais e funcionais

    Directory of Open Access Journals (Sweden)

    Larissa Mont'Alverne Jucá Seabra

    2010-12-01

    Full Text Available Astaxanthin, a carotenoid belonging to the xanthophyll class, has stirred great interest due to its antioxidant capacity and its possible role in reducing the risk of some diseases. Astaxanthin occurs naturally in microalgae, such as Haematococcus pluvialis and the yeast Phaffia rhodozyma, and has also been considered to be the major carotenoid in salmon and crustaceans. Shrimp processing waste, which is generally discarded, is also an important source of astaxanthin. The antioxidant activity of astaxanthin has been observed to modulate biological functions related to lipid peroxidation, having beneficial effects on chronic diseases such as cardiovascular disease, macular degeneration and cancer. Researches have shown that both astaxanthin obtained from natural sources and its synthetic counterpart produce satisfactory effects, but studies in humans are limited to natural sources. There is no established nutritional recommendation regarding astaxanthin daily intake but most studies reported beneficial results from a daily intake of 4mg. Thus, this review discusses some aspects of the carotenoid astaxanthin, highlighting its chemical structure and antioxidant activity, and some studies that report its use in humans.A astaxantina, carotenóide pertencente à classe das xantofilas, tem despertado grande interesse devido à sua capacidade antioxidante e possível papel na redução de risco de algumas doenças. A astaxantina pode ser encontrada naturalmente em microalgas como Haematococcus pluvialis e na levedura Phaffia rhodozyma como também tem sido considerada principal carotenóide em salmão e crustáceos. Os resíduos do processamento de camarão, geralmente descartados, são também importante fonte de astaxantina. A atividade antioxidante da astaxantina tem demonstrado importante função na modulação de funções biológicas relacionadas à peroxidação lipídica, desempenhando efeitos benéficos em doenças crônicas como doen

  19. Aspects of Prediction Accuracy in Human-structure Interaction

    DEFF Research Database (Denmark)

    Pedersen, Lars

    2009-01-01

    Structures such as grandstands in stadia and office floors in buildings are typically occupied by seated persons, and it is a challenge to predict the dynamic characteristics of these structures. This is because the structures and the seated persons interact when the structures undergo vibrations......, basically with the effect that the seated persons influence the dynamic system. The mechanism of the interaction is not well understood, and there are a number of factors that might influence the mechanism of the interaction. Through experiments with a vibrating floor carrying seated humans, the paper looks...... into the mechanism of the interaction focusing on its effect on dynamic structural properties. It is investigated to which extent factors such as posture of the seated persons and the construction type of the seat on which the persons are sitting have a bearing on the structural frequency and damping. This provides...

  20. Some aspects of the interaction between systems- and structural reliability

    International Nuclear Information System (INIS)

    Schueller, G.K.; Schmitt, W.

    1979-01-01

    The purpose of this paper is to study the interaction between systems- and structural reliability analysis with reference to the design of structural components of LWR. Presently the evaluation of systems reliability is carried out apart from structural reliability analysis. Moreover, two basically different methodologies are used for analysis. While in systems analysis the simplified binary approach is still generally accepted, in structural reliability one has to resort to more sophisticated procedures to obtain realistic results. The interactive effect may be illustrated as follows: For example, the integrity of the primary circuit interacts with the integrity of the containment structure. This means that the probability of occurrence of the pipe rupture which may cause a LOCA and consequently leads to a build-up of temperature and pressure within the containment affects directly its structural reliability. The piping system, particularly the primary piping, in turn interacts with the protective system, which is part of the safety system. This piping structure is also subjected to various operational loading conditions. In a numerical example dealing with leakage probabilities of pipes it is shown how methods of structural reliability may be used to gain more insight in the estimation of failure rates of system components. (orig.)

  1. Mathematical aspects of Rietveld refinement and crystal structure ...

    Indian Academy of Sciences (India)

    Administrator

    Bond lengths and angles are calculated using the cell parameters. Using the Rietveld refinement parameters a stable PbTiO3 structure is suggested. Keywords. Rietveld; PbTiO3; XRD; oxides. 1. Introduction. Rietveld refinement technique is a standard treatment of powder diffraction data to make the final structural model.

  2. Nonlinear aspects of structural fatigue damage assessment and accumulation

    International Nuclear Information System (INIS)

    Leis, B.N.

    1977-01-01

    The present paper reviews a recently developed concept for structural fatigue analysis which is capable of accounting for nonlinearities in both the above noted transformations. It is shown that, for cases where the local stressing and straining is proportional, the multiplicity of initiation sites and mechanisms observed to dominate structural fatigue resistance can be explained in terms of these additional nonlinearities. The ability of current concepts for structural fatigue analysis which account for nonlinear action to handle situaions where nonproportional stressing occurs in fatigue critical locations is next examined. Limitations in the assumptions made in fatigue analysis are shown to essentially preclude the application of present technology to that class of problems. A new approach whereby the present fatigue analysis procedures based on a deformation-type plasticity analysis can be extended to handle the nonproportional cycling by their application on a 'memory event' by 'memory event' basis is postulated and discussed in the context of a simple component

  3. Basic materials and structures aspects for hypersonic transport vehicles (HTV)

    Science.gov (United States)

    Steinheil, E.; Uhse, W.

    A Mach 5 transport design is used to illustrate structural concepts and criteria for materials selections and also key technologies that must be followed in the areas of computational methods, materials and construction methods. Aside from the primary criteria of low weight, low costs, and conceivable risks, a number of additional requirements must be met, including stiffness and strength, corrosion resistance, durability, and a construction adequate for inspection, maintenance and repair. Current aircraft construction requirements are significantly extended for hypersonic vehicles. Additional consideration is given to long-duration temperature resistance of the airframe structure, the integration of large-volume cryogenic fuel tanks, computational tools, structural design, polymer matrix composites, and advanced manufacturing technologies.

  4. Structural aspects of crotalic venom proteins modified by ionizing radiation

    International Nuclear Information System (INIS)

    Oliveira, Karina Corleto de

    2010-01-01

    Snake bites are a serious public health problem, especially in subtropical countries. In Brazil, the Ministry of Health notified around 26 000 accidents in 2008. The genus Crotalus (rattlesnakes) accounts for approximately 7% of the total, with a high mortality rate of 72% when untreated with the specific serum, the only effective treatment in case of snake bites. In Brazil, the serum is produced in horses which, despite the large size, have a reduced lifespan due to the high toxicity of the antigen. Ionizing radiation has proven to be an excellent tool for reducing the toxicity of venoms and isolated toxins, resulting in better immunogens for serum production, and contributing to the welfare of serum producing animals. Since the action of gamma radiation on venoms and toxins has not been yet fully clarified from the structural point of view, we proposed in this paper, to characterize two toxins of the species Crotalus durissus terrificus: crotoxin and crotamine. After isolation of the toxins of interest by chromatographic techniques, they were subjected to structural analysis with the application of the following methods: Fluorescence, Circular Dichroism, Differential Calorimetry and Infrared Spectroscopy. These tests showed that both crotamine as crotoxin when subjected to gamma radiation, showed changes in their structural conformation compared with the samples in the native state. Such changes probably occur in the secondary and tertiary structure and may explain the changes on the biological activity of these toxins. (author)

  5. Structure, context, complexity, organization: physical aspects of information and value

    National Research Council Canada - National Science Library

    Eriksson, Karl-Erik; Lindgren, Kristian; Månsson, Bengt Å

    1987-01-01

    ... and of information theory are general enough to play such a role. The authors have been involved in studies of the handling of natural resources in human societies. There we met problems and ideas which led us to the theme of this book: a perspective and a set of concepts, useful for describing and understanding processes in which structure emerges. T...

  6. Structural aspect on the Slano blato landslide (Slovenia

    Directory of Open Access Journals (Sweden)

    Ladislav Placer

    2008-12-01

    Full Text Available The active landslide Slano blato above Lokavec in the Vipava valley, Slovenia, is a complex phenomenon. The hinterland of the landslide consists of the large fossil block of Mala Gora that slid about 300 m down the slope of Mt. Čaven, and was tilted with respect to the slope. We presume that the corresponding failure surface is concavelyshaped. The block consist in its lower part of Eocene flysch beds and in its upper part of Triassic carbonate rocks that are thrust over the flysch. It is probable that due to gravitational slumping the flysch basement obtained a concave shape, that serves as a catchment structure for retaining the ground water. It slowly percolates throughthe crushed calcarenitic layers in flysch. According to available data the Slano blato was triggered in 1887 by earthworks, and in 2000 by natural erosion processes. The structural characteristics allow the assumption that movement occurs in crushed and weathered flysch beds that are percolated by a steady or periodical supply ofgroundwater from the structural reservoir in the Mala Gora fossil slumped block. Coexistence of the older structural and the younger active weathered material landslides can be observed also at other localities along the thrust front of the Trnovo and Hrušica (Nanos nappe. Especially interesting in this respect are the Razdrto and Strane landslides.

  7. Conjugated Polymers and Oligomers: Structural and Soft Matter Aspects

    DEFF Research Database (Denmark)

    conjugated polymer backbone, water soluble conjugated polyelectrolytes and surfactants, conjugated molecules and biomolecules and DNA and the advanced use of synchrotron radiation and electron microscopy to find out structural details in conjugated molecule films and devices as well as under ambient...

  8. Mathematical aspects of Rietveld refinement and crystal structure ...

    Indian Academy of Sciences (India)

    Administrator

    Abstract. The core mathematics, goodness-of-fit parameters of Rietveld refinement technique is introduced for structural analysis of crystalline materials not available as single crystals. X-ray diffraction (XRD) pat- terns of PbTiO3 compound prepared by following solid-state route, suggests it to be in single crystal form. All.

  9. Structural and mechanistic aspects of alcohol dehydrogenase function

    OpenAIRE

    Svensson, Stefan

    1999-01-01

    Vertebrates possess a complex alcohol dehydrogenase (ADH) system composed of multiple molecular forms, which are currently classified into seven classes according to their structural properties. ADHs are dimeric zinc metalloenzymes that catalyze the reversible oxidation of alcohols to aldehydes/ketones using NAD+/NADH as electron acceptor and donor, respectively. The classes have broad but only partially overlapping substrate repertoires. This thesis mainly deals with mechan...

  10. Nuclear Structure Aspects of Neutrinoless Double-β Decay

    Science.gov (United States)

    Brown, B. A.; Horoi, M.; Sen'kov, R. A.

    2014-12-01

    We decompose the neutrinoless double-β decay matrix elements into sums of products over the intermediate nucleus with two less nucleons. We find that the sum is dominated by the Jπ=0+ ground state of this intermediate nucleus for both the light and heavy neutrino decay processes. This provides a new theoretical tool for comparing and improving nuclear structure models. It also provides the connection to two-nucleon transfer experiments.

  11. Structural and Functional Aspects of Class A Carbapenemases.

    Science.gov (United States)

    Naas, Thierry; Dortet, Laurent; Iorga, Bogdan I

    2016-01-01

    The fight against infectious diseases is probably one of the greatest public health challenges faced by our society, especially with the emergence of carbapenem-resistant gram-negatives that are in some cases pan-drug resistant. Currently,β-lactamase-mediated resistance does not spare even the newest and most powerful β-lactams (carbapenems), whose activity is challenged by carbapenemases. The worldwide dissemination of carbapenemases in gram-negative organisms threatens to take medicine back into the pre-antibiotic era since the mortality associated with infections caused by these "superbugs" is very high, due to limited treatment options. Clinically-relevant carbapenemases belong either to metallo-β- lactamases (MBLs) of Ambler class B or to serine-β-lactamases (SBLs) of Ambler class A and D enzymes. Class A carbapenemases may be chromosomally-encoded (SME, NmcA, SFC-1, BIC-1, PenA, FPH-1, SHV-38), plasmid-encoded (KPC, GES, FRI-1) or both (IMI). The plasmid-encoded enzymes are often associated with mobile elements responsible for their mobilization. These enzymes, even though weakly related in terms of sequence identities, share structural features and a common mechanism of action. They variably hydrolyse penicillins, cephalosporins, monobactams, carbapenems, and are inhibited by clavulanate and tazobactam. Three-dimensional structures of class A carbapenemases, in the apo form or in complex with substrates/inhibitors, together with site-directed mutagenesis studies, provide essential input for identifying the structural factors and subtle conformational changes that influence the hydrolytic profile and inhibition of these enzymes. Overall, these data represent the building blocks for understanding the structure-function relationships that define the phenotypes of class A carbapenemases and can guide the design of new molecules of therapeutic interest.

  12. Aspects of wear and tear of tooth structure.

    Science.gov (United States)

    Kahler, Bill

    2010-03-01

    Lifestyle factors and the increased longevity of the dentition due to greater life expectancy have resulted in greater wear and tear (cracking) of teeth. Often there exists interplay between damage and repair. An understanding of these mechanisms of damage and repair will assist the clinician in correct diagnosis and treatment planning. Preventive strategies as well as interdisciplinary measures are required for optimal outcomes. However, are some of our restorative interventions causing further damage to tooth structure?

  13. Electronic structure of proteins and DNA: solid-state aspects.

    Science.gov (United States)

    Ladik, J J

    1978-01-01

    The generalization of the Hartree-Fock method to periodic systems (polymers or crystals) using a linear combination of atomic orbitals (LCAO) makes it possible to calculate ab initio self-consistent-field LCAO band structures of periodic protein and DNA models. The results obtained for polyglycine, polyalanine, and for the mixed poly(Gly-Ala) periodic chain, as well as for the four homopolynucleotides, are presented. The correction of these band structures for excitonic effects (in the excited state) and for long-range correlation effects is shown also. Furthermore, it is outlined how the short-range correlation in insulator biopolymers and correlation effects in proteins with a partially filled valence band (for instance, due to charge transfer) can be calculated. The Coherent Potential Approximation is outlined and its possible application to aperiodic proteins and DNA is pointed out. Finally the effect of an electron acceptor on proteins or of a chemical carcinogen bound to DNA is discussed as a local perturbation of the band structures of these systems on the basis of the self-consistent resolvent method.

  14. Do edaphic aspects alter vegetation structures in the Brazilian restinga?

    Directory of Open Access Journals (Sweden)

    Francisco Soares Santos-Filho

    2013-09-01

    Full Text Available The vegetation of the Brazilian restinga (coastal woodland presents a variety of species and different characteristics, encompassing fields, fruit groves and forests on quartzarenic neosols. We hypothesised that the structure of the restinga landscape along the coast of the state of Piauí is influenced by edaphic factors and presents a pattern similar to that of other northeastern restingas. We evaluated three restingas in Piauí, using the quarter method to determine their structure. Composite soil samples were collected to determine their chemical and physical properties. Edaphic variables were correlated with plant species by canonical correspondence analysis (CCA. Phytosociological data for all three areas indicated regenerating vegetation comprising several small individuals, 82.5% of which showed a diameter at ground level < 13 cm. We also observed considerable tillering. In two of the areas, there was a predominance of Fabaceae species, such as Caesalpinia pyramidalis and Copaifera martii. Although the structural characteristics of the restingas studied were similar to those of other northeastern restingas, the former showed lower Shannon diversity indices (2.18-2.44. The CCA indicated that species distribution was influenced by edaphic factors such as pH, aluminium content and amount of organic matter. The restingas studied were similar to others along the Brazilian coast.

  15. Pollen structure and function in caesalpinioid legumes.

    Science.gov (United States)

    Banks, Hannah; Rudall, Paula J

    2016-03-01

    A diverse range of pollen morphologies occurs within the large, paraphyletic legume subfamily Caesalpinioideae, especially among early-branching lineages. Previous studies have hypothesized an association between surface ornamentation and pollination syndrome or other aspects of pollen function such as desiccation tolerance and adaptations to accommodate volume changes. We reviewed caesalpinioid pollen morphology using light microscopy, scanning and transmission electron microscopy, in combination with a literature survey of pollination vectors. Pollen structural diversity is greatest in the early-branching tribes Cercideae and Detarieae, whereas Cassieae and Caesalpinieae are relatively low in pollen diversity. Functional structures to counter desiccation include opercula (lids) covering apertures and reduced aperture size. Structures preventing wall rupture during dehydration and rehydration include different forms of colpi (syncolpi, parasyncolpi, pseudocolpi), striate supratectal ornamentation, and columellate or granular wall structures that resist tensile or compressive forces respectively. Specialized aperture structures (Zwischenkörper) may be advantageous for efficient germination of the pollen tube. In Detarieae and Cercideae in particular, there is potential to utilize pollen characters to estimate pollination systems where these are unknown. Supratectal verrucae and gemmae have apparently evolved iteratively in Cercideae and Detarieae. At the species level, there is a potential correlation between striate/verrucate patterns and vertebrate pollination. © 2016 Botanical Society of America.

  16. Some Aspects of Multigrid Methods on Non-Structured Meshes

    Science.gov (United States)

    Guillard, H.; Marco, N.

    1996-01-01

    To solve a given fine mesh problem, the design of a multigrid method requires the definition of coarse levels, associated coarse grid operators and inter-grid transfer operators. For non-structured simplified meshes, these definitions can rely on the use of non-nested triangulations. These definitions can also be founded on agglomeration/aggregation techniques in a purely algebraic manner. This paper analyzes these two options, shows the connections of the volume-agglomeration method with algebraic methods and proposes a new definition of prolongation operator suitable for the application of the volume-agglomeration method to elliptic problems.

  17. Metallization of high aspect ratio, out of plane structures

    DEFF Research Database (Denmark)

    Vazquez, Patricia; Dimaki, Maria; Svendsen, Winnie Edith

    2009-01-01

    This work is dedicated to developing a novel three dimensional structure for electrochemical measurements in neuronal studies. The final prototype will allow not only for the study and culture on chip of neuronal cells, but also of brain tissue. The use of out-of-plane electrodes instead of planar...... ones increases the sensitivity of the system and increases the signal-to-noise ratio in the recorded signals, due to the higher availability of surface area. The main bottleneck of the out-of-plane electrode fabrication lies in the metallization process for transforming them into active electrodes...

  18. The Structural Biology of Muscle: Spatial and Temporal Aspects

    Science.gov (United States)

    Holmes, Kenneth C.

    Understanding muscle contraction has resulted from the synergy of a ­number of approaches for which structure has provided an integrating framework. Nearly 60 years ago interference and phase contrast light microscopy established the sliding filament model of muscle contraction. A little later H.E. Huxley exploited electron microscopy to visualize the macromolecular architecture of the sarcomere: the thick (myosin) and thin (actin) filaments with connecting myosin cross-bridges. These observations allowed him to outline a structural basis for muscle contraction: a rowing-like progression of the myosin cross-bridges along the actin filament. X-ray fibre diffraction from insect flight muscle first demonstrated that the cross-bridges could indeed take up two configurations that might represent the ends of an active stroke. Later intense X-ray synchrotron radiation allowed the recording of the movements of the cross-bridges during a contraction with high precision. In 1993 Rayments's group ushered in a much more detailed understanding of myosin function by solving the structure of the myosin cross-bridge by X-ray crystallography. It showed that the cross-bridge consists of a large catalytic domain, often called the motor domain, containing the ATP binding site and the actin binding site. At the C-terminus of the motor domain is a long lever arm. The catalytic mechanism is similar to the G-proteins: the active site contains a P-loop and switch 1 and switch 2 elements. The lever arm was later found in two different conformations (so called pre-power-stroke and post-rigor) showing how switch 2 movement is coupled to a swing of the lever arm. Further crystallographic studies coupled with high resolution em reconstructions of decorated actin (the rigor complex) showed how ATP binding sequesters switch 1 thereby opening the large cleft in the motor domain and breaking the strong binding to actin. Conversely, the strong binding to actin causes a movement of switch 1 with

  19. Some ecological aspects during X-ray structure analysis

    International Nuclear Information System (INIS)

    Mammadov, S.C.; Gurbanov, M.M.; Bayramov, C.C.; Zeynalov, H.I.

    2004-01-01

    Full text : At present solid-state and crystals substances take special place in most fields of our life. Radiography, electron and neutron diffraction analysis are usually held for clarification of the structure of above-mentioned matters. But X-ray analysis got the largest expansion due to its technical possibilities and accuracy of the received results. The basis of this analysis forms the diffraction of X-ray beams through the crystal during which arises air ionization that can render negative influence on associates. Further in clause some stages, directions and also methods of protection during carrying out of X-ray analysis are most in detail described [az

  20. Structural aspects of magnetic fluid stabilization in aqueous agarose solutions

    Science.gov (United States)

    Nagornyi, A. V.; Petrenko, V. I.; Avdeev, M. V.; Yelenich, O. V.; Solopan, S. O.; Belous, A. G.; Gruzinov, A. Yu.; Ivankov, O. I.; Bulavin, L. A.

    2017-06-01

    Structure characterization of magnetic fluids (MFs) synthesized by three different methods in aqueous solutions of agarose was done by means of small-angle neutron (SANS) and synchrotron X-ray scattering (SAXS). The differences in the complex aggregation observed in the studied magnetic fluids were related to different stabilizing procedures of the three kinds of MFs. The results of the analysis of the scattering (mean size of single polydisperse magnetic particles, fractal dimensions of the aggregates) are consistent with the data of transmission electron microscopy (TEM).

  1. Structural Reliability Aspects in Design of Wind Turbines

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard

    2007-01-01

    Reliability assessment, optimal design and optimal operation and maintenance of wind turbines are an area of significant interest for the fast growing wind turbine industry for sustainable production of energy. Offshore wind turbines in wind farms give special problems due to wake effects inside...... the farm. Reliability analysis and optimization of wind turbines require that the special conditions for wind turbine operation are taken into account. Control of the blades implies load reductions for large wind speeds and parking for high wind speeds. In this paper basic structural failure modes for wind...

  2. Atrophy and hypertrophy of skeletal muscles: structural and functional aspects.

    Science.gov (United States)

    Boonyarom, O; Inui, K

    2006-10-01

    This review summarizes current information on structural and functional changes that occur during muscle atrophy and hypertrophy. Most published studies consider an increase in total mass of a muscle as hypertrophy, whereas a decrease in total mass of a muscle is referred to as atrophy. In hypertrophy, the rate of synthesis is much higher than the rate of degradation of muscle contractile proteins, leading to an increase in the size or volume of an organ due to enlargement of existing cells. When a muscle remains in disuse for a long period, the rate of degradation of contractile proteins becomes greater than the rate of replacement, resulting in muscle atrophy. This defect may occur as a result of lack of nutrition, loss of nerve supply, micro-gravity, ageing, systemic disease, prolonged immobilization or disuse. An understanding of the specific modifications that occur during muscle atrophy and hypertrophy may facilitate the development of novel techniques, as well as new therapies for affected muscles.

  3. [Max Weber's illness--sociologic aspects of the depressive structure].

    Science.gov (United States)

    Frommer, J; Frommer, S

    1993-05-01

    Between 1897 and 1902 the economist and sociologist Max Weber from Heidelberg suffered from a severe depressive crisis with multiple recurrences of its symptomatology in the following years. The biographic background of the disease process is examined. Questions regarding the specific diagnosis are discussed. Furthermore, his work shows that Weber was indirectly deeply concerned with the cultural, historical and social background conditions of depressive experience and behavior in the context of his study on Protestantic Ethics and the Spirit of Capitalism. Weber's definition of modern society as an iron cage, determined by Occidental Rationalism, shows that this cultural background demands a great amount of role conformity from the individual. Weber's theoretical approach should spark interest in the current psychopathological discussion of the characteristic structural features of a depressed personality.

  4. Tipificação polínica em Leguminosae de uma área prioritária para conservação da Caatinga: Caesalpinioideae e Papilionoideae Pollen typification of Leguminosae from a priority area for conservation of Caatinga: Caesalpinioideae and Papilionoideae

    Directory of Open Access Journals (Sweden)

    Maria Teresa Buril

    2011-09-01

    Full Text Available O município de Mirandiba, Pernambuco, foi considerado como área prioritária para a conservação da Caatinga e apresenta uma grande diversidade florística. Leguminosae desponta como família mais diversa, representando cerca de 25% das espécies conhecidas para o domínio. Foram caracterizados os grãos de pólen das subfamílias Caesalpinioideae e Papilionoideae, e estabelecidos grupos com afinidades na morfologia polínica. Em Caesalpinioideae, são discutidas diferenças especialmente quanto à ornamentação da exina, marcantes entre os gêneros estudados. Enquanto em Papilionoideae, a variação mais marcante está no tipo de aberturas, sendo encontrados poros, cólporos e colpos. Nas duas subfamílias, a maioria dos gêneros pode ser considerada estenopolínica, restringindo o reconhecimento de espécies por caracteres apenas morfométricos.The municipality of Mirandiba, in Pernambuco, is considered a priority area for conservation of Caatinga and has a diverse flora. In this region, the family with the greatest number of species is the Leguminosae, which is represented by about 25% of the species known from the Caatinga. In this study we characterized the pollen grains of the subfamilies Caesalpinioideae and Papilionoideae, and established groups based on pollen morphology. Differences found within the Caesalpinioideae are discussed, especially exine ornamentation, which is striking between the different genera. In Papilionoideae, the most conspicuous difference was the type of aperture, where pores, colpores, and colpi were observed. In the two subfamilies, most genera are considered stenopalynous, making it difficult recognize species by only morphometric characters.

  5. Mammalian cells exposed to ionizing radiation: structural and biochemical aspects

    International Nuclear Information System (INIS)

    Sabanero, M.; Flores V, L. L.; Azorin V, J. C.; Vallejo, M. A.; Cordova F, T.; Sosa A, M.; Castruita D, J. P.; Barbosa S, G.

    2015-10-01

    Acute or chronic exposure to ionizing radiation is a factor that may be hazardous to health. It has been reported that exposure to low doses of radiation (less than 50 mSv / year) and subsequently exposure to high doses have greater effects in people. However, it is unknown molecular and biochemical level alteration. This study, analyzes the susceptibility of a biological system (HeLa Atcc CCL-2 human cervix cancer cell line) to ionizing radiation (6 and 60 mSv/ 90). Our evaluate multiple variables such as: total protein profile, mitochondrial metabolic activity (XTT assay), cell viability (Trypan blue exclusion assay), cytoskeleton (actin micro filaments), nuclei (D API), genomic DNA. The results indicate, that cells exposed to ionizing radiation structurally show alterations in nuclear phenotype and aneuploidy, further disruption in the tight junctions and consequently on the distribution of actin micro filaments. Similar alterations were observed in cells treated with a genotoxic agent (200μM H 2 O 2 /1 h). In conclusion, this multi-criteria assessment enables precise comparisons of the effects of radiation between any biological systems. However, it is necessary to determine stress markers for integration of the effects of ionizing radiation. (Author)

  6. Theoretical aspects of electronic structure of high Tc superconductors

    International Nuclear Information System (INIS)

    Gupta, R.P.

    1990-01-01

    Although the mechanism responsible for the high T c superconductivity is still unknown, it is nevertheless clear that superconductivity in hole doped materials depends sensitively on the number of holes, C h , per CuO 2 plane. A correlation between C h and T c has been established. In this paper we present several examples of the critical dependence of the charge transfer and thus the value of C h on the cristallographic characteristics. For example, our electronic structure investigations of YBa 2 Cu 3 O 6.5 using several configurations of the oxygen atoms on the chains show that the order-disorder phenomena of the oxygen atoms play a crucial role on the value of C h and T c . We have also studied the variation of the charge transfer and C h as a function of hydrostatic pressure for several cuprates: La 1.85 Sr 0.15 CuO 4 (ΔT c /Δp ∼ 0.3 - 0.4 K/kbar); YBa 2 Cu 4 O 8 (ΔT c /Δp ∼ 5.5 K/kbar). We show that the values of C h increase under pressure [fr

  7. Leaving Flatland: 3-D Aspects of Lagrangian Coherent Structures

    Science.gov (United States)

    Kirwan, A. D.; Huntley, H. S.; Lipphardt, B. L.; Sulman, M.

    2011-12-01

    Methodologies arising from dynamical systems theory are widely used in oceanography to describe flow properties and quantify stirring processes. Of particular interest are special material curves that delineate transport pathways in transient mesoscale eddy fields. To date oceanographic applications have been almost entirely restricted to considerations of the near surface, with the tacit assumption of zero vertical velocity. Even in two dimensions, these material curves are tedious to calculate, and many scientists rely on surrogates such as finite time/space Lyapunov exponents to define Lagrangian Coherent Structures (LCS). Extending such dynamical systems concepts to include depth dependence in a realistic setting presents difficult computational and theoretical challenges. We discuss several of these here. Specifically, we use a range of models, from toy problems to regional data assimilating ocean models, to answer such questions as: Can 3D transport pathways in ocean general circulation models be adequately delineated by material surfaces derived from 2D curves at many levels and stitched together -- or are 3D trajectories, which rely on small and noisy vertical velocity estimates, necessary? How representative are near-surface LCS of LCS below 200 m? What is the shape of LCS around an individual eddy, especially near the bottom of the eddy?

  8. Mammalian cells exposed to ionizing radiation: structural and biochemical aspects

    Energy Technology Data Exchange (ETDEWEB)

    Sabanero, M.; Flores V, L. L. [Universidad de Guanajuato, Departamento de Biologia, DCNE, Noria Alta s/n, 36250 Guanajuato, Gto. (Mexico); Azorin V, J. C.; Vallejo, M. A.; Cordova F, T.; Sosa A, M. [Universidad de Guanajuato, Departamento de Ingenieria Fisica, DCI, Loma del Bosque 103, Col. Lomas del Campestre, 37150 Leon, Guanajuato (Mexico); Castruita D, J. P. [Universidad de Guadalajara, Departamento de Ecologia, CUCBA, Las Agujas, 45100 Zapopan, Jalisco (Mexico); Barbosa S, G., E-mail: myrna.sabanero@gmail.com [Universidad de Guanajuato, Departamento de Ciencias Medicas, DCS, 20 de Enero No. 929, Col. Obregon, 37000 Leon, Guanajuato (Mexico)

    2015-10-15

    Acute or chronic exposure to ionizing radiation is a factor that may be hazardous to health. It has been reported that exposure to low doses of radiation (less than 50 mSv / year) and subsequently exposure to high doses have greater effects in people. However, it is unknown molecular and biochemical level alteration. This study, analyzes the susceptibility of a biological system (HeLa Atcc CCL-2 human cervix cancer cell line) to ionizing radiation (6 and 60 mSv/ 90). Our evaluate multiple variables such as: total protein profile, mitochondrial metabolic activity (XTT assay), cell viability (Trypan blue exclusion assay), cytoskeleton (actin micro filaments), nuclei (D API), genomic DNA. The results indicate, that cells exposed to ionizing radiation structurally show alterations in nuclear phenotype and aneuploidy, further disruption in the tight junctions and consequently on the distribution of actin micro filaments. Similar alterations were observed in cells treated with a genotoxic agent (200μM H{sub 2}O{sub 2}/1 h). In conclusion, this multi-criteria assessment enables precise comparisons of the effects of radiation between any biological systems. However, it is necessary to determine stress markers for integration of the effects of ionizing radiation. (Author)

  9. Structural and microstructural aspects of asbestos-cement waste vitrification

    Science.gov (United States)

    Iwaszko, Józef; Zawada, Anna; Przerada, Iwona; Lubas, Małgorzata

    2018-04-01

    The main goal of the work was to evaluate the vitrification process of asbestos-cement waste (ACW). A mixture of 50 wt% ACW and 50 wt% glass cullet was melted in an electric furnace at 1400 °C for 90 min and then cast into a steel mold. The vitrified product was subjected to annealing. Optical microscopy, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to evaluate the effects of the vitrification. The chemical constitution of the material before and after the vitrification process was also analyzed. It was found that the vitrified product has an amorphous structure in which the components of asbestos-cement waste are incorporated. MIR spectroscopy showed that the absorption bands of chrysotile completely disappeared after the vitrification process. The results of the spectroscopic studies were confirmed by X-ray studies - no diffraction reflections from the chrysotile crystallographic planes were observed. As a result of the treatment, the fibrous asbestos construction, the main cause of its pathogenic properties, completely disappeared. The vitrified material was characterized by higher resistance to ion leaching in an aquatic environment than ACW and a smaller volume of nearly 72% in relation to the apparent volume of the substrates. The research has confirmed the high effectiveness of vitrification in neutralizing hazardous waste containing asbestos and the FT-IR spectroscopy was found to be useful to identify asbestos varieties and visualizing changes caused by the vitrification process. The work also presents the current situation regarding the utilization of asbestos-containing products.

  10. A study of the morphoanatomical characters of the leaves of Chamaecrista (L. Moench sect. Apoucouita (Leguminosae-Caesalpinioideae

    Directory of Open Access Journals (Sweden)

    Ítalo Antônio Cotta Coutinho

    2016-01-01

    Full Text Available ABSTRACT Little attention has been paid to species of Chamaecrista sect. Apoucouita (Leguminosae-Caesalpinioideae, especially regarding anatomical studies. When only vegetative material is available, the identification of such species may be difficult. Additionally, vegetative material of some species of C. sect. Apoucouita may be even harder to identify because they can resemble species of Inga Mill. (Leguminosae-Mimosoideae. The present study focused on recognizing morphoanatomical characters of leaves that are taxonomically useful for the species of C. sect. Apoucouita by employing standard anatomical techniques. The arrangement of the vascular system in the petiole/rachis, dorsiventral mesophyll, mucilage idioblasts in the epidermis of leaflets and hypostomatic leaves were some of the characters shared by all species studied. Length of the petiole, position and type of extrafloral nectaries, leaflet venation, presence and type of papillae on the epidermis of the leaflet blades and sclereids in the mesophyll were some of the characters useful in the distinction of taxa. The vascular arrangement of the petiole/rachis is a promising character in the distinction of species of C. sect. Apoucouita and Inga. Based on morphoanatomical data, the taxonomic revision of some species and varieties ascribed to C. sect. Apoucouita is suggested.

  11. Insect herbivores associated with an evergreen tree Goniorrhachis marginata Taub. (Leguminosae: Caesalpinioideae) in a tropical dry forest.

    Science.gov (United States)

    Silva, J O; Neves, F S

    2014-08-01

    Goniorrhachis marginata Taub. (Leguminosae: Caesalpinioideae) is a tree species found in Brazilian tropical dry forests that retain their leaves during the dry season. That being, we addressed the following question: i) How do insect diversity (sap-sucking and chewing), leaf herbivory and defensive traits (tannin and leaf sclerophylly) vary on the evergreen tree species G. marginata between seasons? The abundance of sap-sucking insects was higher in the dry season than in the rainy season. However, we did not verify any difference in the species richness and abundance of chewing insects between seasons. Leaf herbivory was higher in the rainy season, whereas leaf sclerophylly was higher in the dry season. However, herbivory was not related to sclerophylly. Insect herbivores likely decrease their folivory activity during the dry season due to life history patterns or changes in behaviour, possibly entering diapause or inactivity during this period. Therefore, G. marginata acts as a likely keystone species, serving as a moist refuge for the insect fauna during the dry season in tropical dry forest, and the presence of this evergreen species is crucial to conservation strategies of this threatened ecosystem.

  12. Key Techniques on Preparing High Aspect Ratio Micro and Nano Structures

    DEFF Research Database (Denmark)

    Jian, Zhao; Lianhe, Dong; Xiaoli, Zhu

    2016-01-01

    effectively. The mechanism of action between NaCl and HSQ was analyzed. The collapse and adhesion of resist structure due to the effect of gas-liquid interfacial capillary surface tension were suppressed by the CO2 supercritical drying method. Large-area dense nano-structures with the aspect ratio of 12...

  13. Structural and quantitative aspects of radical formation after heavy ion bombardment

    Energy Technology Data Exchange (ETDEWEB)

    Dusemund, B.; Hoffmann, A.K.; Weiland, B.; Huettermann, J. [Klinikum Homburg (Germany). Fachrichtung Biophysik

    1997-09-01

    In this report the authors present a summary of their recent attempts aiming at clarifying some basic structural and quantitative aspects of free radical formation in DNA constituents and in DNA as well as of product analysis from nucleotide model compounds. (orig./MG)

  14. Lee-side flow structures of very low aspect ratio cruciform wing–body configurations

    CSIR Research Space (South Africa)

    Tuling, S

    2013-12-01

    Full Text Available OF SPACECRAFT AND ROCKETS Vol. 50, No. 6, November–December 2013 Lee-Side Flow Structures of Very Low Aspect Ratio Cruciform Wing–Body Configurations S. Tuling∗ Council for Scientific and Industrial Research, Pretoria 0001, South Africa L. Dala...

  15. Addressing special structure in the relevance feedback learning problem through aspect-based image search

    NARCIS (Netherlands)

    M.J. Huiskes (Mark)

    2004-01-01

    textabstractIn this paper we focus on a number of issues regarding special structure in the relevance feedback learning problem, most notably the effects of image selection based on partial relevance on the clustering behavior of examples. We propose a simple scheme, aspect-based image search, which

  16. Effects of anabolic hormones on structural, metabolic and functional aspects of skeletal muscle

    Directory of Open Access Journals (Sweden)

    Flávio de Oliveira Pires

    2009-01-01

    Full Text Available http://dx.doi.org/10.5007/1980-0037.2009v11n3p350   This study reviewed information regarding the effects of anabolic hormones on strength gain and muscle hypertrophy, emphasizing the physiological mechanisms that may increase muscle strength. Structural, metabolic and functional aspects were analyzed and special attention was paid to the dose-response relationship. The Pubmed database was searched and studies were selected according to relevance and date of publication (last 15 years. The administration of high testosterone doses (~600 mg/week potentiates the effects of strength training, increasing lean body mass, muscle fiber type IIA and IIB cross-sectional area, and the number of myonuclei. There is no evidence of conversion between MHC isoforms. The interaction between testosterone administration and strength training seems to modify some metabolic pathways, increasing protein synthesis, glycogen and ATP-CP muscle stores and improving fat mobilization. Changes in 17-estradiol concentration or in the ACTH-cortisol and insulin-glucagon ratios seem to be associated with these metabolic alterations. Regarding performance, testosterone administration may improve muscle strength by 5-20% depending on the dose used. On the other hand, the effects of growth hormone on the structural and functional aspects of skeletal muscle are not evident, with this hormone more affecting metabolic aspects. However, strictly controlled human studies are necessary to establish the extent of the effects of anabolic hormones on structural, metabolic and functional aspects.

  17. Effects of anabolic hormones on structural, metabolic and functional aspects of skeletal muscle

    Directory of Open Access Journals (Sweden)

    Flávio de Oliveira Pires

    2009-06-01

    Full Text Available This study reviewed information regarding the effects of anabolic hormones on strength gain and muscle hypertrophy, emphasizing the physiological mechanisms that may increase muscle strength. Structural, metabolic and functional aspects were analyzed and special attention was paid to the dose-response relationship. The Pubmed database was searched and studies were selected according to relevance and date of publication (last 15 years. The administration of high testosterone doses (~600 mg/week potentiates the effects of strength training, increasing lean body mass, muscle fiber type IIA and IIB cross-sectional area, and the number of myonuclei. There is no evidence of conversion between MHC isoforms. The interaction between testosterone administration and strength training seems to modify some metabolic pathways, increasing protein synthesis, glycogen and ATP-CP muscle stores and improving fat mobilization. Changes in 17-estradiol concentration or in the ACTH-cortisol and insulin-glucagon ratios seem to be associated with these metabolic alterations. Regarding performance, testosterone administration may improve muscle strength by 5-20% depending on the dose used. On the other hand, the effects of growth hormone on the structural and functional aspects of skeletal muscle are not evident, with this hormone more affecting metabolic aspects. However, strictly controlled human studies are necessary to establish the extent of the effects of anabolic hormones on structural, metabolic and functional aspects.

  18. Fabrication of High Aspect Ratio SU-8 Structures for Integrated Spectrometers

    DEFF Research Database (Denmark)

    Anhøj, Thomas Aarøe

    2007-01-01

    This dissertation deals with the fabrication of integrated spectrometers for use in miniaturized chemical analysis systems, also called 'lab-on-a-chip'-systems. The spectrometers are based on concave re ection gratings, and are fabricated in the epoxy-based material SU-8 by means...... of photolithography. Successful fabrication of re ection gratings requires a high degree of precision in the photolithographic process. The fabrication process has thus been optimized by optimizing the photolithographic process for fabrication of high aspect ratio structures, i.e. structures with details...... of the photolithographic SU-8 fabrication process has caused the aspect ratio of the narrowest resolvable trench to rise from approximately 6 to 11.4. Simultaneously, the optimized process eliminates all problems regarding cracks in the fabricated structures. If the fabrication of the re ection grating is not perfect...

  19. Structural Aspects LiNbO3 Nanoparticles and Their Ferromagnetic Properties

    Science.gov (United States)

    Diaz-Moreno, Carlos A.; Farias-Mancilla, Rurik; Elizalde-Galindo, Jose T.; González-Hernández, Jesus; Hurtado-Macias, Abel; Bahena, Daniel; José-Yacamán, Miguel; Ramos, Manuel

    2014-01-01

    We present a solid-state synthesis of ferromagnetic lithium niobate nanoparticles (LiNbO3) and their corresponding structural aspects. In order to investigate the effect of heat treatments, two batches of samples with a heat-treated (HT) and non-heat-treated (nHT) reduction at 650 °C in 5% of hydrogen/argon were considered to investigate the multiferroic properties and their corresponding structural aspects; using magnetometry and scanning transmission electron microscopy (STEM). Results indicate the existence of ferromagnetic domains with a magnetic moment per unit cell of 5.24 × 10−3 μB; caused mainly due to voids and defects on the nanoparticle surface, as confirmed by STEM measurements. PMID:28788242

  20. Some structural aspects that are relevant for synthesis of planetary gear trains

    Energy Technology Data Exchange (ETDEWEB)

    Rajasri, I. [Pathfinder Engineering College, Hanamkonda (India); Gupta, A.V.S.S.K.S. [JNTU, Hyderabad (India); Rao, Y.V.D. [BITS-Pilani. Dept. of Mechanical Engineering, Hyderabad (India)

    2012-07-01

    Gear Trains are typically used in various mechanisms including wind turbines and robots to transmit specified motion and/or torque between two or more shafts and wind turbines need drives and overdrives that amplify the speed of turbine shaft and provide high speed at generator shaft. Planetary gear trains (PGT) are compact, easy to build and operate. Therefore PGTs are most suitable for such drives including over drives. Graph theory used in synthesis of the PGTs is also useful to identify various possible structural aspects of the PGTs. Generation of PGTs is followed by the test for isomorphism in PGTs generated. In this context various structural aspects relevant for the synthesis of PGTs is described. (Author)

  1. Different methods to alter surface morphology of high aspect ratio structures

    Energy Technology Data Exchange (ETDEWEB)

    Leber, M., E-mail: moritz.leber@utah.edu [Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT (United States); Shandhi, M.M.H. [Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT (United States); Hogan, A. [Blackrock Microsystems, Salt Lake City, UT (United States); Solzbacher, F. [Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT (United States); Bhandari, R.; Negi, S. [Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT (United States); Blackrock Microsystems, Salt Lake City, UT (United States)

    2016-03-01

    Graphical abstract: Surface engineering of high aspect ratio silicon structures. - Highlights: • Multiple roughening techniques for high aspect ratio devices were investigated. • Modification of surface morphology of high aspect ratio silicon devices (1:15). • Decrease of 76% in impedance proves significant increase in surface area. - Abstract: In various applications such as neural prostheses or solar cells, there is a need to alter the surface morphology of high aspect ratio structures so that the real surface area is greater than geometrical area. The change in surface morphology enhances the devices functionality. One of the applications of altering the surface morphology is of neural implants such as the Utah electrode array (UEA) that communicate with single neurons by charge injection induced stimulation or by recording electrical neural signals. For high selectivity between single cells of the nervous system, the electrode surface area is required to be as small as possible, while the impedance is required to be as low as possible for good signal to noise ratios (SNR) during neural recording. For stimulation, high charge injection and charge transfer capacities of the electrodes are required, which increase with the electrode surface. Traditionally, researchers have worked with either increasing the roughness of the existing metallization (platinum grey, black) or other materials such as Iridium Oxide and PEDOT. All of these previously investigated methods lead to more complicated metal deposition processes that are difficult to control and often have a critical impact on the mechanical properties of the metal films. Therefore, a modification of the surface underneath the electrode's coating will increase its surface area while maintaining the standard and well controlled metal deposition process. In this work, the surfaces of the silicon micro-needles were engineered by creating a defined microstructure on the electrodes surface using several

  2. Structural analysis of reinforced concrete structures under monotonous and cyclic loadings: numerical aspects

    International Nuclear Information System (INIS)

    Lepretre, C.; Millard, A.; Nahas, G.

    1989-01-01

    The structural analysis of reinforced concrete structures is usually performed either by means of simplified methods of strength of materials type i.e. global methods, or by means of detailed methods of continuum mechanics type, i.e. local methods. For this second type, some constitutive models are available for concrete and rebars in a certain number of finite element systems. These models are often validated on simple homogeneous tests. Therefore, it is important to appraise the validity of the results when applying them to the analysis of a reinforced concrete structure, in order to be able to make correct predictions of the actual behaviour, under normal and faulty conditions. For this purpose, some tests have been performed at I.N.S.A. de Lyon on reinforced concrete beams, subjected to monotonous and cyclic loadings, in order to generate reference solutions to be compared with the numerical predictions given by two finite element systems: - CASTEM, developed by C.E.A./.D.E.M.T. - ELEFINI, developed by I.N.S.A. de Lyon

  3. Structural aspects of some hydrobenzofuran neolignans; Aspectos estruturais de algumas neolignanas hidrobenzofuranicas

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, Massayoshi, E-mail: myoshida@iq.usp.br [Universidade de Sao Paulo (IQ/USP), SP (Brazil). Inst. de Quimica; Centro de Biotecnologia da Amazonia, Manaus, AM (Brazil)

    2012-07-01

    The neolignans are defined as dimers of allylphenol and propenylphenol between itself or crossed, whose bond does not occur by the 8-8' carbons like lignans. This review centered on stereochemical aspects of the hydrobenzofuran type, a widespread skeleton among neolignans. The chemical structures established based on spectrometric data are registered in the literature. The absolute configurations reported previously were determined by chiroptical techniques. Some chemical transformations with neolignans, performed in previous studies, afforded products which are accumulated in other vegetal species and contributed to assign the unknown stereochemistry of these natural compounds. Possible biosynthetic pathways are also proposed. (author)

  4. Morphoanatomy of nectaries of Chamaecrista (L. Moench sections Chamaecrista , Caliciopsis and Xerocalyx (Leguminosae: Caesalpinioideae

    Directory of Open Access Journals (Sweden)

    Marinalva dos Santos Silva

    Full Text Available ABSTRACT Nectaries are specialized structures that secrete nectar. Several species of Chamaecrista possess nectaries on the petiole, which have been shown to vary widely in morphology and the chemical nature of their secretion. However, a comprehensive investigation of the nectaries of the clade formed by sect. Chamaecrista, Caliciopsis and Xerocalyx has yet to be performed. Our study aimed to confirm whether or not the leaf glands of species of this clade are in fact nectaries, determine the chemical nature of their secretion and expand the morphoanatomical database on leaf nectaries in Chamaecrista with the intention of contributing to the taxonomy and phylogeny of the genus. Samples from herbarium and field-collected material were subjected to standard methods for light and scanning electron microscopy. Four different forms of nectaries were observed: urceolate, patelliform, verruciform and cupuliform. The nectaries were found to comprise a single-layered epidermis, nectary parenchyma, subnectary parenchyma and vascularization. Polysaccharides, lipids, phenolic compounds and proteins were detected in secretions. Although anatomical similarities were observed among the studied species, their morphology differed. Moreover, the glands are indeed nectaries and are similar to those observed in other species of the genus Chamaecrista. These data hold potential taxonomic usefulness for the studied sections.

  5. Load assumption for fatigue design of structures and components counting methods, safety aspects, practical application

    CERN Document Server

    Köhler, Michael; Pötter, Kurt; Zenner, Harald

    2017-01-01

    Understanding the fatigue behaviour of structural components under variable load amplitude is an essential prerequisite for safe and reliable light-weight design. For designing and dimensioning, the expected stress (load) is compared with the capacity to withstand loads (fatigue strength). In this process, the safety necessary for each particular application must be ensured. A prerequisite for ensuring the required fatigue strength is a reliable load assumption. The authors describe the transformation of the stress- and load-time functions which have been measured under operational conditions to spectra or matrices with the application of counting methods. The aspects which must be considered for ensuring a reliable load assumption for designing and dimensioning are discussed in detail. Furthermore, the theoretical background for estimating the fatigue life of structural components is explained, and the procedures are discussed for numerous applications in practice. One of the prime intentions of the authors ...

  6. Problematic Alcohol Use and Problem Gambling: Associations to Structural and Functional aspects of Social Ties in a Finnish Population Sample

    Directory of Open Access Journals (Sweden)

    Nordmyr Johanna

    2016-09-01

    Full Text Available AIMS – This study aims to explore associations between structural and functional aspects of social networks and relationships (here labelled social ties among individuals exhibiting problematic alcohol use and problem gambling, respectively.

  7. The Contradictions and Compartmentalizing the Interactions between Integrated Business Structures: Aspect of Branding

    Directory of Open Access Journals (Sweden)

    Nifatova Olena M.

    2017-04-01

    Full Text Available The article is aimed at identifying contradictions and developing a compartmentalizing as to the interaction between integrated business structures, taking into consideration the branding approach to management. The main specific features and contradictions that arise in the process of integration in the domestic market of mergers and acquisitions have been allocated. The contradictions identified were systematized and substantiated at three economic levels: macro-, meso-, and microeconomic. A compartmentalizing of the business units interaction in a merge or an acquisition process has been proposed. This compartmentalizing takes account of the branding aspect through the introduction of «brands interaction» – cluster interaction, circular interaction, holding interaction, linear interaction, which enhances the scientific view of exploring the problem of business units interaction in the process of the formations becoming integrated. The development of a compartmentalizing as to the interaction between integrated business structures, taking into consideration the branding approach to management, would provide a more effective use of the fundamental nature of branding as synergistic force in terms of the system of integration of business structures at the current stage of development of the national economy. Further development of branding issues in this sphere will have a significant impact on the functioning of the integrated business structures with the participation of Ukrainian companies.

  8. Some aspects of the chemistry of fast reactor fuel, structural material and decontamination

    International Nuclear Information System (INIS)

    Ganesan, V.

    2012-01-01

    The chemistry of materials pertaining to fast reactors is both fascinating and challenging considering the nature of materials involved such as the fuel, coolant, control and shielding materials in addition to the interactions between the structural materials and the fuel/coolant depending on the nature and conditions involved. The different chemical forms of fuel materials, the need to operate up to high burnups with consequent interactions of the fuel with clad materials, the need to close the fuel cycle by recovery of the fuel materials from spent fuels for refabrication and the necessity to manage the waste, throw a host of challenges which make their study scientifically interesting and technologically important. The use of liquid sodium as coolant in fast reactor heat transport systems combined with its inherent chemical reactivity opens up an interesting branch of chemistry involving liquid sodium especially in contact with structural materials during normal operation of the reactor and with fuels in the event of fuel pin failure. The phenomenon of sodium wetting and the associated corrosion of structural materials in contact with it combined with the need to carryout decontamination of such materials make it interesting to examine and evaluate their suitability for reuse without compromising on their structural integrity. Boron being the material of choice for control and shielding applications in fast reactors with varying isotopic enrichment and the technological challenge to produce large quantities of boron carbide makes it unique. Some of these aspects are addressed in this paper. (author)

  9. Fabrication of high-aspect-ratio nano structures using a nano x-ray shadow mask

    International Nuclear Information System (INIS)

    Kim, Yong Chul; Lee, Seung S

    2008-01-01

    This paper describes a novel method for the fabrication of high-aspect-ratio nano structures (HAR-nano structures) using a nano x-ray shadow mask and deep x-ray lithography (DXRL). The nano x-ray shadow mask is fabricated by depositing an x-ray absorber layer (Au, 3 µm) onto the back side of a nano shadow mask. The nano shadow mask is produced with nano-sized apertures whose dimensions are reduced to several tens of nanometers by the accumulation of low-stress silicon nitride (Si x N y ) using the LPCVD process on the shadow mask. A shadow mask containing apertures with a size of 1 µm is fabricated on a bulk micromachined Si x N y membrane. The thickness of an absorber layer must be in the range of several tens of micrometers in order to obtain a contrast of more than 100 for the conventional DXRL process at the Pohang Light Source (PLS). However, a 3 µm thick absorber layer can provide a sufficient contrast if the modified DXRL of the central beam-stop method is used, which blocks high-energy x-rays. A nano shadow mask with 30 nm sized apertures is fabricated and a nano x-ray shadow mask with 250 nm sized apertures is fabricated by depositing a 3 µm thick absorber layer on a nano shadow mask with 500 nm sized apertures. HAR-nano structures (circles with a diameter of 420 nm and lines with a width of 274 nm) with aspect ratios of over 10:1 on a 3.2 µm SU-8 are successfully fabricated by using the nano x-ray shadow mask and the central beam-stop method

  10. Caesalpiniaceae (Leguminosae-Caesalpinioideae)

    NARCIS (Netherlands)

    Hou, Ding; Larsen, K.; Larsen, S.S.

    1996-01-01

    In Malesia the family contains 25 indigenous genera and 8 genera with only introduced species, as follows (in brackets the number of native and/or introduced species in Malesia): Acrocarpus (1), Afzelia (2), Amherstia (1), Bauhinia (69), Brownea (4), Caesalpinia (22), Cassia (4), Chamaecrista (5),

  11. Aspect has a greater impact on alpine soil bacterial community structure than elevation.

    Science.gov (United States)

    Wu, Jieyun; Anderson, Barbara J; Buckley, Hannah L; Lewis, Gillian; Lear, Gavin

    2017-03-01

    Gradients in environmental conditions, including climate factors and resource availability, occur along mountain inclines, providing a 'natural laboratory' to explore their combined impacts on microbial distributions. Conflicting spatial patterns observed across elevation gradients in soil bacterial community structure suggest that they are driven by various interacting factors at different spatial scales. Here, we investigated the relative impacts of non-resource (e.g. soil temperature, pH) and resource conditions (e.g. soil carbon and nitrogen) on the biogeography of soil bacterial communities across broad (i.e. along a 1500 m mountain elevation gradient) and fine sampling scales (i.e. along sunny and shady aspects of a mountain ridge). Our analysis of 16S rRNA gene data confirmed that when sampling across distances of soil pH. These findings highlight the need to incorporate knowledge of multiple factors, including site aspect and soil pH for the appropriate use of elevation gradients as a proxy to explore the impacts of climate change on microbial community composition. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  12. A review of the structural aspects of the Large Coil Task

    International Nuclear Information System (INIS)

    Lubell, M.S.; Clinard, J.A.; Lue, J.W.; Luton, J.N.; McManamy, T.J.; Shen, S.S.

    1987-01-01

    The Large Coil Task (LCT) was initiated a decade ago by the United States (US), EURATOM (EU), Japan (JA), and Switzerland (CH) under the auspices of the International Energy Agency (IEA) to develop superconducting magnets for toroidal field coils for tokamak fusion reactors. Under the IEA agreement, EU, JA, and CH each fabricated one coil and shipped it to the Oak Ridge National Laboratory (ORNL), where the coils were assembled, along with three US coils (GD, GE, and WH), in the International Fusion Superconducting Magnet Test Facility (IFSMTF) which was designed and built at ORNL. In addition to the fact that six widely varying designs are being tested under similar conditions in the same test facility, the LCT project is unique in at least two other aspects. First, these are the largest superconducting (SC) coils fabricated and tested to date for research and development of SC magnets. Second, as the magnets themselves are the experiment, they are each heavily instrumented; consequently, detailed information on thermal, electrical, and mechanical performance has been obtained, some for the first time on SC magnets of any size. This paper concentrates on those aspects of the tests most relevant for fusion reactor magnets: the structural measurements and simulated nuclear heating tests. Data on the US PB coils (GD and GE) and the US FF coil (WH) are used to illustrate the results. All six coils have achieved 100% design current at 8-T field and that in a symmetric torus arrangement all six coils have been simultaneously energized to 8 T

  13. Simulation and Measurement of Neuroelectrodes' Characteristics with Integrated High Aspect Ratio Nano Structures

    Directory of Open Access Journals (Sweden)

    Christoph Nick

    2015-07-01

    Full Text Available Improving the interface between electrodes and neurons has been the focus of research for the last decade. Neuroelectrodes should show small geometrical surface area and low impedance for measuring and high charge injection capacities for stimulation. Increasing the electrochemically active surface area by using nanoporous electrode material or by integrating nanostructures onto planar electrodes is a common approach to improve this interface. In this paper a simulation approach for neuro electrodes' characteristics with integrated high aspect ratio nano structures based on a point-contact-model is presented. The results are compared with experimental findings conducted with real nanostructured microelectrodes. In particular, effects of carbon nanotubes and gold nanowires integrated onto microelectrodes are described. Simulated and measured impedance properties are presented and its effects onto the transfer function between the neural membrane potential and the amplifier output signal are studied based on the point-contact-model. Simulations show, in good agreement with experimental results, that electrode impedances can be dramatically reduced by the integration of high aspect ratio nanostructures such as gold nanowires and carbon nanotubes. This lowers thermal noise and improves the signal-to-noise ratio for measuring electrodes. It also may increase the adhesion of cells to the substrate and thus increase measurable signal amplitudes.

  14. Scale for positive aspects of caregiving experience: development, reliability, and factor structure.

    Science.gov (United States)

    Kate, N; Grover, S; Kulhara, P; Nehra, R

    2012-06-01

    OBJECTIVE. To develop an instrument (Scale for Positive Aspects of Caregiving Experience [SPACE]) that evaluates positive caregiving experience and assess its psychometric properties. METHODS. Available scales which assess some aspects of positive caregiving experience were reviewed and a 50-item questionnaire with a 5-point rating was constructed. In all, 203 primary caregivers of patients with severe mental disorders were asked to complete the questionnaire. Internal consistency, test-retest reliability, cross-language reliability, split-half reliability, and face validity were evaluated. Principal component factor analysis was run to assess the factorial validity of the scale. RESULTS. The scale developed as part of the study was found to have good internal consistency, test-retest reliability, cross-language reliability, split-half reliability, and face validity. Principal component factor analysis yielded a 4-factor structure, which also had good test-retest reliability and cross-language reliability. There was a strong correlation between the 4 factors obtained. CONCLUSION. The SPACE developed as part of this study has good psychometric properties.

  15. Structural, Chemical and Biological Aspects of Antioxidants for Strategies Against Metal and Metalloid Exposure

    Directory of Open Access Journals (Sweden)

    Swaran J. S. Flora

    2009-01-01

    Full Text Available Oxidative stress contributes to the pathophysiology of exposure to heavy metals/metalloid. Beneficial renal effects of some medications, such as chelation therapy depend at least partially on the ability to alleviate oxidative stress. The administration of various natural or synthetic antioxidants has been shown to be of benefit in the prevention and attenuation of metal induced biochemical alterations. These include vitamins, N-acetylcysteine, α-lipoic acid, melatonin, dietary flavonoids and many others. Human studies are limited in this regard. Under certain conditions, surprisingly, the antioxidant supplements may exhibit pro-oxidant properties and even worsen metal induced toxic damage. To date, the evidence is insufficient to recommend antioxidant supplements in subject with exposure to metals. Prospective, controlled clinical trials on safety and effectiveness of different therapeutic antioxidant strategies either individually or in combination with chelating agent are indispensable. The present review focuses on structural, chemical and biological aspects of antioxidants particularly related to their chelating properties.

  16. [Maintainance of a research tissue bank. (Infra)structural and quality aspects].

    Science.gov (United States)

    Schmitt, S; Kynast, K; Schirmacher, P; Herpel, E

    2015-11-01

    The availability of high quality human tissue samples and access to associated histopathological and clinical data are essential for biomedical research. Therefore, it is necessary to establish quality assured tissue biobanks that provide high quality tissue samples for research purposes. This entails quality concerns referring not only to the biomaterial specimen itself but encompassing all procedures related to biobanking, including the implementation of structural components, e.g. ethical and legal guidelines, quality management documentation as well as data and project management and information technology (IT) administration. Moreover, an integral aspect of tissue biobanks is the quality assured evaluation of every tissue specimen that is stored in a tissue biobank and used for projects to guarantee high quality assured biomaterial.

  17. Aspergillus niger biofilms for celulasas production: some structural and physiological aspects

    Directory of Open Access Journals (Sweden)

    Gretty K. Villena

    2013-06-01

    Full Text Available Aspergillus niger biofilms developed on polyester cloth were evaluated considering two aspects related to the growth on surfaces: structure and physiological behavior focused on cellulase production. The biofilm structure was assessed by using electron scanning microphotographs from inoculation and adsorption to 120 h growth. The microphotographs show that biofilm formation can be divided into three phases: 1 Adhesion, which is strongly increased by Aspergillus spore hydrophobicity; 2 Initial growth and development phase from spore germination, that begins 4 to 10 h after inoculation and continues up to 24 h when almost all available surface has been colonized; 3 Maturation phase in which biomass density is highly increased from 48 h after inoculation until 120 h growth when an internal channel organization that assures medium flow through biofilm is clearly evident as it is frequently reported for bacterial biofilms.Biofilm cellulolytic enzyme activity and productivity were also evaluated, being up to 40% and 55%, respectively, higher than that attained by freely suspended cultures. These results are in agreement with the behavior of most surface living microorganisms, which generally show a higher metabolic activity because of a differential gene expression. This work is a first attempt to understand the structure and physiology of industrial filamentous fungal biofilms as a response to the scarce available information in comparison with the vast and detailed information related to bacterial and pathogenic yeast biofilms.

  18. A conserved host and pathogen recognition site on immunoglobulins: structural and functional aspects.

    Science.gov (United States)

    Wines, Bruce D; Trist, Halina M; Farrugia, William; Ngo, Chloe; Trowsdale, John; Areschoug, Thomas; Lindahl, Gunnar; Fraser, John D; Ramsland, Paul A

    2012-01-01

    A common site in the constant region (Fc) of immunoglobulins is recognized by host receptors and is a frequent target of proteins expressed by pathogens. This site is located at the junction of two constant domains in the antibody heavy chains and produces a large shallow cavity formed by loops of the CH2 and CH3 domains in IgG and IgA (CH3 and CH4 domains in IgM). Crystal structures have been determined for complexes of IgG-Fc and IgA-Fc with a structurally diverse set of host, pathogen and in vitro selected ligands. While pathogen proteins may directly block interactions with the immunoglobulins thereby evading host immunity, it is likely that the same pathogen molecules also interact with other host factors to carry out their primary biological function. Herein we review the structural and functional aspects of host and pathogen molecular recognition of the common site on the Fc of immunoglobulins. We also propose that some pathogen proteins may promote virulence by affecting the bridging between innate and adaptive immunity.

  19. Topology optimization aided structural design: Interpretation, computational aspects and 3D printing.

    Science.gov (United States)

    Kazakis, Georgios; Kanellopoulos, Ioannis; Sotiropoulos, Stefanos; Lagaros, Nikos D

    2017-10-01

    Construction industry has a major impact on the environment that we spend most of our life. Therefore, it is important that the outcome of architectural intuition performs well and complies with the design requirements. Architects usually describe as "optimal design" their choice among a rather limited set of design alternatives, dictated by their experience and intuition. However, modern design of structures requires accounting for a great number of criteria derived from multiple disciplines, often of conflicting nature. Such criteria derived from structural engineering, eco-design, bioclimatic and acoustic performance. The resulting vast number of alternatives enhances the need for computer-aided architecture in order to increase the possibility of arriving at a more preferable solution. Therefore, the incorporation of smart, automatic tools in the design process, able to further guide designer's intuition becomes even more indispensable. The principal aim of this study is to present possibilities to integrate automatic computational techniques related to topology optimization in the phase of intuition of civil structures as part of computer aided architectural design. In this direction, different aspects of a new computer aided architectural era related to the interpretation of the optimized designs, difficulties resulted from the increased computational effort and 3D printing capabilities are covered here in.

  20. Geometrical aspects of quantum walks on random two-dimensional structures.

    Science.gov (United States)

    Anishchenko, Anastasiia; Blumen, Alexander; Mülken, Oliver

    2013-12-01

    We study the transport properties of continuous-time quantum walks (CTQWs) over finite two-dimensional structures with a given number of randomly placed bonds and with different aspect ratios (ARs). Here, we focus on the transport from, say, the left side to the right side of the structure where absorbing sites are placed. We do so by analyzing the long-time average of the survival probability of CTQWs. We compare the results to the classical continuous-time random walk case (CTRW). For small ARs (landscape configurations) we observe only small differences between the quantum and the classical transport properties, i.e., roughly the same number of bonds is needed to facilitate the transport. However, with increasing ARs (portrait configurations) a much larger number of bonds is needed in the CTQW case than in the CTRW case. While for CTRWs the number of bonds needed decreases when going from small ARs to large ARs, for CTQWs this number is large for small ARs, has a minimum for the square configuration, and increases again for increasing ARs. We explain our findings by analyzing the average eigenstates of the corresponding structures: The participation ratios allow us to distinguish between localized and nonlocalized (average) eigenstates. In particular, for large ARs we find for CTQWs that the eigenstates are localized for bond numbers exceeding the bond numbers needed to facilitate transport in the CTRW case. Thus, a rather large number of bonds is needed in order for quantum transport to be efficient for large ARs.

  1. Integrating content and structure aspects of the self: traits, values, and self-improvement.

    Science.gov (United States)

    Roccas, Sonia; Sagiv, Lilach; Oppenheim, Shani; Elster, Andrey; Gal, Avigail

    2014-04-01

    Research on the structure of the self has mostly developed separately from research on its content. Taking an integrative approach, we studied two structural aspects of the self associated with self-improvement--self-discrepancies and perceived mutability--by focusing on two content areas, traits and values. In Studies 1A-C, 337 students (61% female) reported self-discrepancies in values and traits, with the finding that self-discrepancies in values are smaller than in traits. In Study 2 (80 students, 41% female), we experimentally induced either high or low mutability and measured perceived mutability of traits and values. We found that values are perceived as less mutable than traits. In Study 3, 99 high school students (60% female) reported their values, traits, and the extent to which they wish to change them. We found that values predict the wish to change traits, whereas traits do not predict the wish to change values. In Study 4, 172 students (47.7% female) were assigned to one of four experimental conditions in which they received feedback denoting either uniqueness or similarity to others, on either their values or their traits. The results indicated that feedback that one's values (but not traits) are unique affected self-esteem. Integrating between theories of content and structure of the self can contribute to the development of both. © 2013 Wiley Periodicals, Inc.

  2. Conceptualization of Design Safety Aspect and Seismic Qualification to Structure, System and Nuclear Power Plant Components

    International Nuclear Information System (INIS)

    Akhmad Muktaf Haifani

    2009-01-01

    Conceptualization of Design Safety Aspect and Seismic Qualification To Structure, System and Nuclear Power Plant Components. This paper discuss about earthquake base design that is classified based on level of probability occurrences to be seismic level 1 (SL-1) related with operation requirement and seismic level 2 (SL-2) related with the most strict requirement. Such recommendation should be given to classify structure, system and component of nuclear power plant into four categories based on functional requirements of safety during and after earthquake, load combination, as well as code design in order to define seismic characteristics. Seismic categorization of structure, system and component will differ between PWR and BWR based on type of cooling system and also level of theirs safety. Analysis method suggested in this paper use direct method (dynamic time history, dynamic spectrum response analysis, static equivalent analysis, and table and graphic analysis) and in direct method (comparison between the same qualifications). By implementing this design concept, earthquake with design concept on site will not endanger the safety of nuclear power plant installation. (author)

  3. Topological aspects of lanthanide–adipate–aqua compounds: Close packed and open framework structures

    Energy Technology Data Exchange (ETDEWEB)

    Chowdhuri, Durga Sankar; Kumar Jana, Swapan; Hazari, Debdoot [Department of Chemistry and Chemical Technology, Vidyasagar University, Midnapore 721 102, West Bengal (India); Zangrando, Ennio, E-mail: ezangrando@units.it [Department of Chemical and Pharmaceutical Sciences, Via L. Giorgieri 1, 34127 Trieste (Italy); Dalai, Sudipta, E-mail: sudipta@mail.vidyasagar.ac.in [Department of Chemistry and Chemical Technology, Vidyasagar University, Midnapore 721 102, West Bengal (India)

    2013-07-15

    A search in the Cambridge Structural Database (CSD) for lanthanide complexes with adipate [OOC(CH{sub 2}){sub 4}COO]{sup 2−} and aqua ligands retrieved a fair number of compounds. To this dataset a new lanthanum metal–organic framework, ([La{sub 2}(adip){sub 3}(H{sub 2}O){sub 2}] (1) (adipH{sub 2}=adipic acid), synthesised and structurally characterized in these labs, was included. The crystal structures of these coordination polymers, of general formulation [Ln{sub 2}(adip){sub 3}(H{sub 2}O){sub x}], exhibit a variety of topologies and dimensionality, which were clustered in different classes and described in detail. It was explored that the majority of these evidences the presence of metal chains or dinuclear Ln{sub 2} entities (separated in both cases by 4.0–4.8 Å), where lanthanide ions are differently connected by carboxylate groups with chelating or oxygen-bridging mode. The different amount of coordinated water molecules appear to affect the solid state networks. Moreover the crystal packing of these compounds shows peculiar aspects and examples were reported in the literature where the long alkyl chain of adipate connectors give rise to interpenetrated structures, or to porous material where lattice water or neutral larger molecules are clathrated. - Graphical abstract: A survey of structures and topologies of lanthanide adipate compounds is presented. A newly synthesized lanthanium adipate complex ([La{sub 2}(adip){sub 3}(H{sub 2}O){sub 2}] (adipH{sub 2}=adipic acid) is also reported. - Highlights: • The use of lanthanide and adipic acid demonstrate the possibility to construct coordination polymer of different dimensionality. • The number of coordination and adipate conformation influence the different topologies. • The ionic radii of the rare earth cations seem also to affect the architecture observed.

  4. Exotic nuclei: another aspect of nuclear structure; Les noyaux exotiques: un autre regard sur la structure nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Dobaczewski, J. [Warsaw Univ., Institute of Theoretical Physics (Poland); Blumenfeld, Y.; Flocard, H.; Garcia Borge, M.J.; Nowacki, F.; Rombouts, S.; Theisen, Ch.; Marques, F.M.; Lacroix, D.; Dessagne, P.; Gaeggeler, H

    2002-07-01

    This document gathers the lectures made at the Joliot Curie international summer school in 2002 whose theme that year was exotic nuclei. There were 11 contributions whose titles are: 1) interactions, symmetry breaking and effective fields from quarks to nuclei; 2) status and perspectives for the study of exotic nuclei: experimental aspects; 3) the pairing interaction and the N = Z nuclei; 4) borders of stability region and exotic decays; 5) shell structure of nuclei: from stability to decay; 6) variational approach of system with a few nucleons; 7) from heavy to super-heavy nuclei; 8) halos, molecules and multi-neutrons; 9) macroscopic approaches for fusion reactions; 10) beta decay: a tool for spectroscopy; 11) the gas phase chemistry of super-heavy elements.

  5. Bosch-like method for creating high aspect ratio poly(methyl methacrylate) (PMMA) structures

    KAUST Repository

    Haiducu, Marius

    2012-02-02

    This paper presents a method for etching millimetre-deep trenches in commercial grade PMMA using deep-UV at 254 nm. The method is based on consecutive cycles of irradiation and development of the exposed areas, respectively. The exposure segment is performed using an inexpensive, in-house built irradiation box while the development part is accomplished using an isopropyl alcohol (IPA):H2O developer. The method was tested and characterized by etching various dimension square test structures in commercial grade, mirrored acrylic. The undercut of the sidewalls due to the uncollimated nature of the irradiation light was dramatically alleviated by using a honeycomb metallic grid in between the irradiation source and the acrylic substrate and by rotating the latter using a direct current (DC) motor-driven stage. By using an extremely affordable set-up and non-toxic, environmentally friendly materials and substances, this process represents an excellent alternative to microfabricating microfluidic devices in particular and high aspect ratio structures in general using PMMA as substrate. © 2012 SPIE.

  6. Statistical aspects of discerning indel-type structural variation via DNA sequence alignment

    Directory of Open Access Journals (Sweden)

    Wilson Richard K

    2009-08-01

    Full Text Available Abstract Background Structural variations in the form of DNA insertions and deletions are an important aspect of human genetics and especially relevant to medical disorders. Investigations have shown that such events can be detected via tell-tale discrepancies in the aligned lengths of paired-end DNA sequencing reads. Quantitative aspects underlying this method remain poorly understood, despite its importance and conceptual simplicity. We report the statistical theory characterizing the length-discrepancy scheme for Gaussian libraries, including coverage-related effects that preceding models are unable to account for. Results Deletion and insertion statistics both depend heavily on physical coverage, but otherwise differ dramatically, refuting a commonly held doctrine of symmetry. Specifically, coverage restrictions render insertions much more difficult to capture. Increased read length has the counterintuitive effect of worsening insertion detection characteristics of short inserts. Variance in library insert length is also a critical factor here and should be minimized to the greatest degree possible. Conversely, no significant improvement would be realized in lowering fosmid variances beyond current levels. Detection power is examined under a straightforward alternative hypothesis and found to be generally acceptable. We also consider the proposition of characterizing variation over the entire spectrum of variant sizes under constant risk of false-positive errors. At 1% risk, many designs will leave a significant gap in the 100 to 200 bp neighborhood, requiring unacceptably high redundancies to compensate. We show that a few modifications largely close this gap and we give a few examples of feasible spectrum-covering designs. Conclusion The theory resolves several outstanding issues and furnishes a general methodology for designing future projects from the standpoint of a spectrum-wide constant risk.

  7. Potential pollinators of Comolia ovalifolia DC Triana (Melastomataceae and Chamaecrista ramosa (Vog. H.S. Irwin and Barneby var. ramosa (Leguminosae-Caesalpinioideae, in restinga, Bahia, Brazil

    Directory of Open Access Journals (Sweden)

    P. Oliveira-Rebouças

    Full Text Available Comolia ovalifolia DC Triana (Melastomataceae and Chamaecrista ramosa (Vog. H.S. Irwin and Barneby var. ramosa (Leguminosae - Caesalpinioideae are tropical plant species found in restinga (herbaceous-shrubby, sandy costal ecosystems. They have flowers with poricidal anthers and are pollinated by bees. The study sought to analyse potential pollinators of both plants during visits to their flowers in a restinga area in Bahia. The flowering displayed by both species was considered continuous and long duration, constantly providing pollen to floral visitors. C. ovalifolia was visited by 17 species of bees and C. ramosa by 16 species, predominantly from the Apidae family (with a similarity index of 74%. The behavior displayed by these visiting bees was of vibrating anthers. The small-sized Euglossa sp. Latreille, 1802 and Florilegus similis Urban, 1970 bees played less of a role as pollinators, since they rarely touched the flower stigma during harvests and were thus considered opportunist visitors or casual pollinators. Centris decolorata Lepetier, 1841 (= C. leprieuri and Xylocopa subcyanea Perez, 1901 are large bees and were considered efficient pollinators of C. ovalifolia and C. ramosa because of the higher frequency and constancy of their visits, and their favourable behaviour and size for pollen transfer between flowers, which guarantees the survival of these native restinga plant species.

  8. Structural and dynamical aspects of skin studied by multiphoton excitation fluorescence microscopy-based methods.

    Science.gov (United States)

    Bloksgaard, Maria; Brewer, Jonathan; Bagatolli, Luis A

    2013-12-18

    This mini-review reports on applications of particular multiphoton excitation microscopy-based methodologies employed in our laboratory to study skin. These approaches allow in-depth optical sectioning of the tissue, providing spatially resolved information on specific fluorescence probes' parameters. Specifically, by applying these methods, spatially resolved maps of water dipolar relaxation (generalized polarization function using the 6-lauroyl-2-(N,N-dimethylamino)naphthale probe), activity of protons (fluorescence lifetime imaging using a proton sensitive fluorescence probe--2,7-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein) and diffusion coefficients of distinct fluorescence probes (raster imaging correlation spectroscopy) can be obtained from different regions of the tissue. Comparative studies of different tissue strata, but also between equivalent regions of normal and abnormal excised skin, including applications of fluctuation correlation spectroscopy on transdermal penetration of liposomes are presented and discussed. The data from the different studies reported reveal the intrinsic heterogeneity of skin and also prove these strategies to be powerful noninvasive tools to explore structural and dynamical aspects of the tissue. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. Integrated Transcriptome Map Highlights Structural and Functional Aspects of the Normal Human Heart.

    Science.gov (United States)

    Caracausi, Maria; Piovesan, Allison; Vitale, Lorenza; Pelleri, Maria Chiara

    2017-04-01

    A systematic meta-analysis of the available gene expression profiling datasets for the whole normal human heart generated a quantitative transcriptome reference map of this organ. Transcriptome Mapper (TRAM) software integrated 32 gene expression profile datasets from different sources returning a reference value of expression for each of the 43,360 known, mapped transcripts assayed by any of the experimental platforms used in this regard. Main findings include the visualization at the gene and chromosomal levels of the classical description of the basic histology and physiology of the heart, the identification of suitable housekeeping reference genes, the analysis of stoichiometry of gene products, and the focusing on chromosome 21 genes, which are present in one excess copy in Down syndrome subjects, presenting cardiovascular defects in 30-40% of cases. Independent in vitro validation showed an excellent correlation coefficient (r = 0.98) with the in silico data. Remarkably, heart/non-cardiac tissue expression ratio may also be used to anticipate that effects of mutations will most probably affect or not the heart. The quantitative reference global portrait of gene expression in the whole normal human heart illustrates the structural and functional aspects of the whole organ and is a general model to understand the mechanisms underlying heart pathophysiology. J. Cell. Physiol. 232: 759-770, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  10. THEORETICAL ASPECTS, EXPERIMENTAL INVESTIGATIONS AND EFFICIENCY IN USAGE OF HIGH-STRENGTH CONCRETE FOR BRIDGE STRUCTURES

    Directory of Open Access Journals (Sweden)

    G. D. Liakhevich

    2014-01-01

    Full Text Available In Belarus concrete with strength up to 60 MPA is used for construction. At the same time high strength concrete with compressive strength above 60 MPA is widely used in all industrially developed countries. High- strength concrete is included in regulatory documents of the European Union and that fact has laid a solid foundation for its application. High strength concrete is produced using highly dispersed silica additives, such as micro-silica and plasticizers (super-plasticizers with a water/cement (w/c ratio not greater than 0.4.Theoretical aspects of high-strength concrete for bridge structures have been studied in the paper. The paper shows a positive impact of highly dispersed additives on structure and physico-mechanical properties of cement compositions, namely: reduction of total porosity of a cement stone in concrete while increasing volumetric concentration and dispersion of a filler; binding of calcium hydroxide with the help of amorphised micro-silica; increased activity of mineral additives during their thin shredding; acceleration of the initial stage of chemical hardening of cement compositions with highly dispersed particle additives that serve as centers of crystallization; “binder-additive” cluster formation due to high surface energy of highly dispersed additive particles; hardening of surface area between a cement stone and aggregates in concrete; high-strength concretes are gaining strength much faster than conventional concretes.Technology of preparation and composition of high-strength concrete using highly dispersed mineral additives and super-plasticizer has been developed in the paper. This concrete will ensure a higher density, wa- ter-and gas tightness, increased resistance to aggressive environment, reduced consumption of concrete and reinforcement, reduced transport and installation weight, increased initial strength, early easing of shutters and preliminary compression, increased length of bridge spans

  11. Dielectrophoretically structured piezoelectric composites with high aspect ratio piezoelectric particles inclusions

    NARCIS (Netherlands)

    Ende, D.A. van den; Kempen, S.E. van; Wu, X.; Groen, W.A.; Randall, C.A.; Zwaag, S. van der

    2012-01-01

    Piezoelectric composites were prepared by dielectrophoretic alignment of high aspect ratio piezoelectric particles in a thermosetting polymer matrix. A high level of alignment was achieved in the cured composite from a resin containing randomly oriented high aspect ratio particles. Upon application

  12. Presynaptic [Ca2+] and GCAPs: aspects on the structure and function of photoreceptor ribbon synapses

    Directory of Open Access Journals (Sweden)

    Frank eSchmitz

    2014-02-01

    Full Text Available Changes in intracellular calcium ions [Ca2+] play important roles in photoreceptor signalling. Consequently, intracellular [Ca2+] levels need to be tightly controlled. In the light-sensitive outer segments (OS of photoreceptors, Ca2+ regulates the activity of retinal guanylate cyclases (ret-GCs thus playing a central role in phototransduction and light-adaptation by restoring light-induced decreases in cGMP. In the synaptic terminals, changes of intracellular Ca2+ trigger various aspects of neurotransmission. Photoreceptors employ tonically active ribbon synapses that encode light-induced, graded changes of membrane potential into different rates of synaptic vesicle exocytosis. The active zones of ribbon synapses contain large electron-dense structures, synaptic ribbons, that are associated with large numbers of synaptic vesicles. Synaptic coding at ribbon synapses differs from synaptic coding at conventional (phasic synapses. Recent studies revealed new insights how synaptic ribbons are involved in this process. This review focuses on the regulation of [Ca2+] in presynaptic photoreceptor terminals and on the function of a particular Ca2+-regulated protein, the neuronal calcium sensor protein GCAP2 (guanylate cyclase-activating protein-2 in the photoreceptor ribbon synapse. GCAP2, an EF hand-containing protein plays multiple roles in the OS and in the photoreceptor synapse. In the OS, GCAP2 works as a Ca2+-sensor within a Ca2+-regulated feedback loop that adjusts cGMP levels. In the photoreceptor synapse, GCAP2 binds to RIBEYE, a component of synaptic ribbons, and mediates Ca2+-dependent plasticity at that site. Possible mechanisms are discussed.

  13. Ionic core–shell dendrimers with a polycationic core: structural aspects and host–guest binding properties

    NARCIS (Netherlands)

    van de Coevering, R.; Bruijnincx, P.C.A.; Lutz, M.; Spek, A.L.; van Koten, G.; Klein Gebbink, R.J.M.

    2007-01-01

    The structural aspects and host–guest binding properties of ionic core–shell dendrimers [1]Br8 and [2]Br4, which bear a polycationic core and a neutral shell of Fréchet-type poly(benzyl aryl ether) dendrons, have been investigated by means of dendritic wedges [3]Br2 and [4]Br, that resemble one of

  14. General aspects of slip from technique in the construction of containment structure of the Narora Atomic Power Station

    International Nuclear Information System (INIS)

    Tilak, M.M.

    1975-01-01

    The paper describes one of the modern techniques of construction methods, i.e. use of slip form technique. Important features in adopting the above technique and its impact on construction aspects and design parameters in respect of containment structure are briefly discussed. (author)

  15. Bacterial vaginosis (clue cell-positive discharge) : diagnostic, ultra-structural and therapeutic aspects

    NARCIS (Netherlands)

    W.I. van der Meijden (Willem)

    1987-01-01

    textabstractThis thesis deals with several aspects of (abnormal) vaginal discharge, focusing especially on clue cell-positive discharge (bacterial vaginosis, nonspecific vaginitis). It reports data on epidemiology and clinical features, pathogenesis, and treatment of this vaginal disease entity,

  16. Ecologie et gestion des espèces multi-usages du genre Erythrophleum (Fabaceae-Caesalpinioideae en Afrique (synthèse bibliographique

    Directory of Open Access Journals (Sweden)

    Gorel, AP.

    2015-01-01

    Full Text Available Ecology and management of the multipurpose Erythrophleum species (Fabaceae-Caesalpinioideae in Africa. A review. Introduction. Widespread in Africa, the Erythrophleum genus includes four tropical tree species with a high economic and socio-cultural value: Erythrophleum ivorense, Erythrophleum suaveolens, Erythrophleum africanum and Erythrophleum lasianthum. Appropriate knowledge of the ecology and the distribution of these species is required for their sustainable management. This paper is based on an extensive literature review and summarizes the available information on the African Erythrophleum species in terms of botany, phylogeography, ecology, forestry and ethnobotany. Literature. Erythrophleum ivorense, E. suaveolens, E. africanum and E. lasianthum are morphologically different and occur in distinct climatic areas. They are non-pioneer light demander (E. ivorense and E. suaveolens or pioneer species (E. africanum. Their primary mode of dispersal is via ballochore. The seeds have a dormancy period and can remain in the soil for several years. Their reproductive and foliar phenologies are regular and annual. Growth rate varies between species, ranging from 0.65 cm per year for E. ivorense to 0.16 cm per year for E. africanum. These trees are used in traditional medicine. Only E. ivorense and E. suaveolens (Tali are mainly logged for timber. Conclusions. Erythrophleum species ecological data are better informed for E. ivorense and E. suaveolens because of their economic importance. This review highlights the existing lack of knowledge regarding the phenology (effects of climate, fructification periods, the minimum diameter of fructification and the mechanisms of natural seed dormancy breakage. Targeting such weaknesses is required to create or re-evaluate methods of conservation and/or enhancement of populations and logging practices.

  17. High aspect ratio nano-fabrication of photonic crystal structures on glass wafers using chrome as hard mask.

    Science.gov (United States)

    Hossain, Md Nazmul; Justice, John; Lovera, Pierre; McCarthy, Brendan; O'Riordan, Alan; Corbett, Brian

    2014-09-05

    Wafer-scale nano-fabrication of silicon nitride (Si x N y ) photonic crystal (PhC) structures on glass (quartz) substrates is demonstrated using a thin (30 nm) chromium (Cr) layer as the hard mask for transferring the electron beam lithography (EBL) defined resist patterns. The use of the thin Cr layer not only solves the charging effect during the EBL on the insulating substrate, but also facilitates high aspect ratio PhCs by acting as a hard mask while deep etching into the Si x N y . A very high aspect ratio of 10:1 on a 60 nm wide grating structure has been achieved while preserving the quality of the flat top of the narrow lines. The presented nano-fabrication method provides PhC structures necessary for a high quality optical response. Finally, we fabricated a refractive index based PhC sensor which shows a sensitivity of 185 nm per RIU.

  18. Fabrication of high aspect ratio nanopillars and micro/nano combined structures with hydrophobic surface characteristics by injection molding

    Science.gov (United States)

    Zhou, Mingyong; Xiong, Xiang; Jiang, Bingyan; Weng, Can

    2018-01-01

    Polymer products with micro/nano-structures have excellent mechanical and optical properties, chemical resistance, and other advantages. Injection molding is one of the most potential techniques to fabricate polymer products with micro/nano-structures artificially in large numbers. In this study, a surface approach to fabricate high aspect ratio nanopillars and micro/nano combined structures was presented. Mold insert with micropillar arrays and nanopillars on its surface was prepared by combing anodic aluminum oxide (AAO) template and etched plate. Anti-sticking modification was done on the template to realize a better demolding quality. The influences of mold temperature and polymer material on the final replication quality were investigated. The results showed that the final replication quality of high aspect ratio nanopillars was greatly improved as compared with the unprocessed template. Polymer with low elongation at break was not suitable to fabricate structures with high aspect ratio via injection molding. For polypropylene surface, the experimental results of static contact angles were almost consistent with Cassie-Baxter equation. When the mold temperature reached 178 °C, hair-like polycarbonate nanopillars were observed, resulting in an excellent hydrophobic characteristic.

  19. Crystal structure of aspartame anhydrate from powder diffraction data. Structural aspects of the dehydration process of aspartame

    NARCIS (Netherlands)

    Guguta, C.; Meekes, H.L.M.; Gelder, R. de

    2006-01-01

    Aspartame has three pseudo-polymorphic forms, two hydrates and a hemi-hydrate, for which crystal structures were determined from single-crystal diffraction data. This paper presents the crystal structure of the anhydrate, which was obtained by dehydrating the hemi-hydrate. The crystal structure of

  20. Controllable fabrication of periodic arrays of high-aspect-ratio micro-nano hierarchical structures and their superhydrophobicity

    Science.gov (United States)

    Ma, Zhibo; Jiang, Chengyu; Li, Xiangming; Ye, Fang; Yuan, Weizheng

    2013-09-01

    This paper demonstrates a flexible and controllable fabrication of vertically aligned and high-aspect-ratio (HAR) micro-nano hierarchical structures using conventional micro-technologies. We first masked the nanopatterns on a photoresist mold by shifting the same photomask, which could be performed using conventional contact microlithography. Thereby replicating nanopatterns onto an aluminium mold and successfully fabricating silicon nanopillar arrays about 300 nm in diameter and 5 µm in height via the deep reactive etching (DRIE) process. We also fabricated micro-nano hierarchical structures with variable aspect ratios using the proposed nanopattern technology and DRIE process without using any special nanopatterning equipment or techniques. The proposed method not only simplified the fabrication process but also produced HAR (higher than 15) structures. We also investigate the replica molding steps from the fabricated silicon stamp to a UV-curable polymer replica using a PDMS mold and conventional nano-imprinting, where each nanopillar diameter was 320 nm with 95% fidelity. As a result, the hierarchical structure arrays show stable superhydrophobic surface properties with a contact angle of approximately 160°. Owing to the cost efficiency of mass production and the fidelity of the strategy, the methodology could provide a general approach for fabricating complex three-dimensional periodic hierarchical structures onto a single chip and can be applied to various fields of multifunctional applications.

  1. A nanoscale conical polymethyl methacrylate (PMMA) sub-wavelength structure with a high aspect ratio realized by a stamping method.

    Science.gov (United States)

    Kim, Dae-Seon; Kim, Dong-Hyun; Jang, Jae-Hyung

    2013-04-08

    A high aspect ratio conical sub-wavelength structure (SWS) was designed by using rigorous coupled-wave analysis (RCWA) method and was realized on polymethyl methacrylate (PMMA) film using a stamping technique. The silicon template containing a hexagonal array of conical holes with a period of 350 nm and an aspect ratio of 2.8 was fabricated by electron-beam (e-beam) lithography followed by a two-step etching process. The SWS with a high aspect ratio was easily transferred from the fabricated silicon template to PMMA film using the stamping method. The replicated PMMA SWS has an array of cones with nanoscale tips and an aspect ratio higher than 2.8. The average reflectance and transmittance of the PMMA film with the conical SWS in the wavelength ranging from 500 and 1500 nm was improved from 7.1 and 91.1% to 4.3 and 94.2%, respectively, as compared to flat PMMA film.

  2. Thermal, structural, and fabrication aspects of diamond windows for high power synchrotron x-ray beamlines

    International Nuclear Information System (INIS)

    Khounsary, A.M.; Phillips, W.

    1992-01-01

    Recent advances in chemical vapor deposition (CVD) technology have made it possible to produce thin free-standing diamond foils that can be used as the window material in high heat load, synchrotron beamlines. Numerical simulations suggest that these windows can offer an attractive and at times the only altemative to beryllium windows for use in third generation x-ray synchrotron radiation beamlines. Utilization, design, and fabrication aspects of diamond windows for high heat load x-ray beamlines are discussed, as are the microstructure characteristics bearing on diamond's performance in this role. Analytic and numerical results are also presented to provide a basis for the design and testing of such windows

  3. Structural aspects of high-Tc superconductors from neutron profile refinement studies

    International Nuclear Information System (INIS)

    Sequeira, A.

    1991-01-01

    The new high-temperature (high-Tc) superconductors have evoked worldwide interest in detecting and characterising their structure and properties. Among the variety of techniques used to characterise these materials, neutron profile refinement using polycrystalline samples has provided the most definitive information regarding their bulk crystal structures. At Trombay the structures of a variety of high-Tc superconductors in the Y-Ba-Cu-O, Tl-Ba-Ca-Cu-O and Bi-Sr-Ca-Cu-O systems have been investigated by neutron diffraction at the high-flux DHRUVA reactor. The results of these investigations are reviewed within the context of the current structural models of these materials and some of the novel structural features observed are highlighted. (orig.)

  4. Structural and Functional Aspects of the Sensor Histidine Kinase PrrB from Mycobacterium tuberculosis

    DEFF Research Database (Denmark)

    Nowak, E.; Panjikar, S.; Morth, J.P.

    2006-01-01

    We describe the solution structures of two- and three-domain constructs of the sensor histidine kinase PrrB from Mycobacterium tuberculosis, which allow us to locate the HAMP linker relative to the ATP binding and dimerization domains. We show that the three-domain construct is active both...... for autophosphorylation and for phosphotransfer to the cognate response regulator, PrrA. We also describe the high-resolution crystal structure of the catalytic domain alone, and we show that, in solution, it binds ATP. The conformational flexibility of this domain is discussed and related to other structural information....

  5. Aspects of Structure and Dynamics at a Refugee Centre in Denmark

    DEFF Research Database (Denmark)

    Mackrill, Thomas Edward

    1996-01-01

    This article presents an empirical analysis that is part of a practice research project carried out at a Danish Red Cross refugee centre in Copenhagen. It focuses on the relation between the individual refugee and the receiving institution. It points out how the organizational structure of a part...... of a particular refugee centre enables discord between refugees and centre workers as well as among the centre staff. It analyses some of the dynamics of the conflicts that are facilitated by the structure...

  6. DOSTOEVSKY'S CONCEPT OF HOLY BODY IN THE STRUCTURE OF "THE BROTHERS KARAMAZOV" (RELIGIOUS AND AESTHETIC ASPECTS

    Directory of Open Access Journals (Sweden)

    Natalia Zhivolupova

    2012-12-01

    Full Text Available The problem of the aesthetic and philosophical significance of the body in Dostoevsky’s creative writing is intimately connected with the structure of his formally intricate novels. The inner structure of Dostoevsky's novels illuminates the representation of the body in his opus as an innate part of Dostoevsky's poetics. The concept of the body includes an aesthetic as well as philosophical spectrum of problems, to which the interest in the topic from both literary critics and philosophers attests.

  7. [Several structural aspects of the interaction of yeast hexokinase with insulin].

    Science.gov (United States)

    Rubenchik, A I; Konev, S V

    1976-01-01

    It has been noted that due to formation of the complex with insuline light and hear resistance of hexokinase from baker's yeast rises. Variation of luminescence parameters shows structural modification of enzyme upon complex formation. On the basis of comparison the photoinactivation data and hexokinase photolysis conclusion has been drawn that the tryptophanyl residues are not directly involved in the enzyme active site, although play an important role in supporting the specific structure.

  8. Aspects of Structure and Dynamics at a Refugee Centre in Denmark

    DEFF Research Database (Denmark)

    Mackrill, Thomas Edward

    1996-01-01

    This article presents an empirical analysis that is part of a practice research project carried out at a Danish Red Cross refugee centre in Copenhagen. It focuses on the relation between the individual refugee and the receiving institution. It points out how the organizational structure...... of a particular refugee centre enables discord between refugees and centre workers as well as among the centre staff. It analyses some of the dynamics of the conflicts that are facilitated by the structure...

  9. Structural aspects of glass-formation in Ni-Nb melts

    Science.gov (United States)

    Holland-Moritz, D.; Yang, F.; Gegner, J.; Hansen, T.; Ruiz-Martín, M. D.; Meyer, A.

    2014-05-01

    We report on investigations of the static structure factors of glass-forming Ni59.5Nb40.5 alloy melts by combination of the containerless processing technique of electrostatic levitation with neutron diffraction. By application of the isotopic substitution method, the full set of partial structure factors was determined. The short-range order in liquid Ni59.5Nb40.5 is characterized by a large nearest neighbor coordination number of ZNN = 14.3 and a chemical short-range order with an affinity for the formation of heterogeneous Nb-Ni nearest neighbors. The structure factors observed here in the liquid state closely resemble those reported for amorphous Nb-Ni solids. The comparison with earlier results on the short-range structure in Zr-based glass-forming melts suggests that a large local density of packing, chemical order, and structural frustration are, amongst others, common structural properties of these metallic glass-forming systems, which favor glass-formation.

  10. The structure and institutions: a regional aspect of interaction in the economic system

    Directory of Open Access Journals (Sweden)

    Leonid Stepanovich Tarasevich

    2014-09-01

    Full Text Available In the article with the help of two-sector model of the economic system, the interaction of national and regional economy is investigated. This interaction is observed from the position of development of material structure and institutions. As the key structural parameter of an economy, the proportion between sector of excess resources and sector of scarce resources is taken. The situation when sector of excess resources prevails over sector of scarce resources forms structural conditions for the creation of the market institutions. If a sector of excess resources is smaller than a sector of scarce resources, the conditions for the emergence of institutions of government regulation are formed. Two cases are analyzed: the first one concerns the situation of a simple national economy consisting of 2 provisory regions. The second is the case of the national economy consisting of many regions. The authors show that material structure of a total combination of regions defines institutions of the market or state regulation for the national economy as a whole. The institutions formed at the level of the national economy, can support or resist the development of structure of the region. The conditions are observed under which united institutions of the national economy contradict a development of structure of the individual region.

  11. Electrical properties of transparent CNT and ITO coatings on PET substrate including nano-structural aspects

    Science.gov (United States)

    Park, Joung-Man; Wang, Zuo-Jia; Kwon, Dong-Jun; Gu, Ga-Young; Lawrence DeVries, K.

    2013-01-01

    Ultraviolet (UV)-visible spectra and surface resistance measurement were used to investigate optical transmittance and conductive properties of carbon nanotube (CNT) and indium tin oxide (ITO) coated polyethylene terephthalate (PET) substrates. Conductive CNT and ITO coatings were successfully fabricated on PET by a spray-coating method. Thin coatings of both materials exhibited good conductivity and transparency. Changes in electrical and optical properties of the coatings were studied as a function of the coating suspension concentration. Interfacial durability of the coatings on PET substrates was also investigated under fatigue and bending loads. CNT coated substrates, with high aspect ratios, exhibited no detectable change in surface resistance up to 2000 cyclic loadings, whereas the ITO coated substrates exhibited a substantial increase in surface resistance at 1000 loading cycles. This change in resistance is attributed to a reduction in the number and effectiveness of the electrical contact points due to the inherent brittle nature of ITO.

  12. Multibody system dynamics for bio-inspired locomotion: from geometric structures to computational aspects.

    Science.gov (United States)

    Boyer, Frédéric; Porez, Mathieu

    2015-03-26

    This article presents a set of generic tools for multibody system dynamics devoted to the study of bio-inspired locomotion in robotics. First, archetypal examples from the field of bio-inspired robot locomotion are presented to prepare the ground for further discussion. The general problem of locomotion is then stated. In considering this problem, we progressively draw a unified geometric picture of locomotion dynamics. For that purpose, we start from the model of discrete mobile multibody systems (MMSs) that we progressively extend to the case of continuous and finally soft systems. Beyond these theoretical aspects, we address the practical problem of the efficient computation of these models by proposing a Newton-Euler-based approach to efficient locomotion dynamics with a few illustrations of creeping, swimming, and flying.

  13. A computer lab exploring evolutionary aspects of chromatin structure and dynamics for an undergraduate chromatin course*.

    Science.gov (United States)

    Eirín-López, José M

    2013-01-01

    The study of chromatin constitutes one of the most active research fields in life sciences, being subject to constant revisions that continuously redefine the state of the art in its knowledge. As every other rapidly changing field, chromatin biology requires clear and straightforward educational strategies able to efficiently translate such a vast body of knowledge to the classroom. With this aim, the present work describes a multidisciplinary computer lab designed to introduce undergraduate students to the dynamic nature of chromatin, within the context of the one semester course "Chromatin: Structure, Function and Evolution." This exercise is organized in three parts including (a) molecular evolutionary biology of histone families (using the H1 family as example), (b) histone structure and variation across different animal groups, and (c) effect of histone diversity on nucleosome structure and chromatin dynamics. By using freely available bioinformatic tools that can be run on common computers, the concept of chromatin dynamics is interactively illustrated from a comparative/evolutionary perspective. At the end of this computer lab, students are able to translate the bioinformatic information into a biochemical context in which the relevance of histone primary structure on chromatin dynamics is exposed. During the last 8 years this exercise has proven to be a powerful approach for teaching chromatin structure and dynamics, allowing students a higher degree of independence during the processes of learning and self-assessment. Copyright © 2013 International Union of Biochemistry and Molecular Biology, Inc.

  14. Caracterização de alfagalactosidase e sua relação com a germinação das sementes de Caesalpinia peltophoroides (Leguminosae Caesalpinioideae Alphagalactosidase characterization and its relationship with seed germination of Caesalpinia peltophoroides (Legumonosae Caesalpinioideae

    Directory of Open Access Journals (Sweden)

    Eduardo Euclydes de Lima e Borges

    2005-08-01

    Full Text Available Sementes de Caesalpinia peltophoroides (Leguminosae Caesalpinioideae - sibipiruna - foram colocadas para embebição por 144 h, sendo retiradas amostras para análise de proteína, quantificações da atividade de alfagalactosidase e de açúcares presentes na micrópila. A germinação iniciou-se com 96 h de embebição, sem que fossem detectadas modificações na parede celular da micrópila. Nesta, observou-se maior proporção de arabinose, que mostrou tendência de aumento com o decorrer da embebição. A atividade específica da alfagalactosidase foi detectada em sementes secas, tanto no eixo embrionário quanto nos cotilédones, aumentando no primeiro a partir de 24 h de embebição. O aumento da atividade nos cotilédones foi mais lento, sendo mais acentuado a partir de 120 h de embebição. O teor de proteína decresceu continuamente no eixo embrionário a partir de 24 horas de embebição, enquanto se manteve estável nos cotilédones. A atividade da alfagalactosidase foi máxima nas temperaturas de 55 e 50 ºC para o eixo embrionário e para os cotilédones, respectivamente. O pH que mais estimulou a atividade da enzima foi na faixa de 5,5 a 6,0 para o eixo embrionário e na de 4,5 a 5,0 para os cotilédones. As alfagalactosidase do eixo embrionário e dos cotilédones foram inibidas por SDS, CuSO4, galactose e melibiose. Não houve efeito estimulante sobre a atividade da alfagalactosidase do eixo embrionário por nenhum dos efetores, enquanto o mercaptoetanol estimulou a atividade da enzima dos cotilédones. Os K M para o substrato ro-NPGal para a alfagalactosidase do eixo embrionário e dos cotilédones foram de 1,74 e 2,64 mM, respectivamente.Caesalpinia peltophoroides (Leguminosae Caesalpinioideae seeds were soaked in water for 144 hours. Samples were taken for protein analysis, quantification of alphagalactosidase activity and micropyle sugar composition. Germination began after 96 hours of imbibition, with no modifications in

  15. Anatomia dos órgãos vegetativos de Hymenaea martiana Hayne (Caesalpinioideae-Fabaceae: espécie de uso medicinal em Caetité-BA Anatomy of vegetative organs of Hymenaea martiana Hayne (Fabaceae-Caesalpinioideae: a species of medicinal use in Caetité-Bahia State, Brazil

    Directory of Open Access Journals (Sweden)

    M.S. Silva

    2012-01-01

    Full Text Available Hymenaea martiana Hayne (Fabaceae-Caesalpinioideae apresenta grande valor na medicina popular em Caetité. A casca, entrecasca do caule e a resina, são utilizadas no tratamento de diversos males. Neste estudo são apresentadas a caracterização anatômica e histoquímica dos órgãos vegetativos. Amostras foram coletadas e processadas segundo técnicas usuais em anatomia vegetal e histoquímica. Todos os órgãos apresentam, em visão transversal, epiderme unisseriada e cavidades secretoras. Cutícula espessa ocorre em todos os órgãos aéreos. A raiz é tetrarca. Colênquima lacunar foi encontrado no caule. Bainha de fibras esclerenquimáticas envolve os feixes vasculares dos órgãos aéreos. Células pétreas ocorrem no pecíolo. Tricomas tectores ocorrem em ambas as faces da folha. A folha é hipoestomática com estômatos paracíticos e o mesofilo é dorsiventral. Cristais de oxalato de cálcio ocorrem no caule, pecíolo e lâmina foliar. Compostos fenólicos ocorrem na raiz, pecíolo e nervura central da folha. Grãos de amido ocorrem na raiz, caule e pecíolo. Lipídios ocorrem em todos os órgãos. Acredita-se que compostos fenólicos e cavidades secretoras de resina podem justificar a utilidade medicinal da espécie pela população de Caetité.Hymenaea martiana Hayne (Fabaceae-Caesalpinioideae shows a great value in folk medicine in Caetité. Its bark, stem-bark and resin are used to treat various ailments. In this study, the anatomical and histochemical characterization of vegetative organs is reported. Samples were collected and processed according to usual techniques of plant anatomy and histochemistry. All organs have, by cross-sectional view, uniseriate epidermis and secretory cavities. Thick cuticle occurs in all aerial organs. The root is tetrarch. Lacunar collenchyma was found in the stem. Sclerenchymatic sheath of fibers surrounds the vascular bundles of the aerial organs. Stone cells occur in the petiole. Trichomes occur

  16. Structural and evolutionary aspects of algal blue light receptors of the cryptochrome and aureochrome type.

    Science.gov (United States)

    Essen, Lars-Oliver; Franz, Sophie; Banerjee, Ankan

    2017-10-01

    Blue-light reception plays a pivotal role for algae to adapt to changing environmental conditions. In this review we summarize the current structural and mechanistic knowledge about flavin-dependent algal photoreceptors. We especially focus on the cryptochrome and aureochrome type photoreceptors in the context of their evolutionary divergence. Despite similar photochemical characteristics to orthologous photoreceptors from higher plants and animals the algal blue-light photoreceptors have developed a set of unique structural and mechanistic features that are summarized below. Copyright © 2017 Elsevier GmbH. All rights reserved.

  17. Cyberlexicography in LSP: New Aspects of Components and Structures in the Dictionary

    DEFF Research Database (Denmark)

    Laursen, Anne Lise; Duvå, Grete

    2005-01-01

    In the pre-electronic days the structure of a dictionary was discussed within pre-established frames, the controversial part being - more or less - how much information to include and in which order. Electronic devices offer a much wider set of possibilities within which no obvious pattern seems...... to have been established. In this paper, we shall focus on the strengths and weaknesses of a number of existing electronic dictionaries, and we shall make some suggestions as to how to reach an optimum and how to change the components and the structures of the internet dictionary accordingly....

  18. What do children know and understand about universal gravitation? Structural and developmental aspects

    NARCIS (Netherlands)

    Frappart, S.; Raijmakers, M.; Frède, V.

    2014-01-01

    Children's understanding of universal gravitation starts at an early age but changes until adulthood, which makes it an interesting topic for studying the development and structure of knowledge. Children's understanding of gravitation was tested for a variety of contexts and across a wide age range

  19. Conformational aspects of dibenzo-tetroxecin: A structural, Raman spectroscopic and computational study

    Science.gov (United States)

    Gordon, Keith C.; McAdam, C. John; Moratti, Stephen C.; Shillito, Georgina E.; Simpson, Jim

    2017-10-01

    Crystalline dibenzo-tetroxecin (I) has been prepared from a reaction between catechol and dichloromethane and its molecular and crystal structure, together with the Raman spectrum of the material in the solid state and in solution, is reported. The molecular structure shows the molecule adopts an anti or stepped conformation. Density functional theory (DFT) optimisation and frequency calculations using the B3LYP functional with the 6-31G(d) basis set showed the presence of syn- and anti-conformers of (I), with the anti-conformer predicted to be the lower in energy by 13.6 kJ mol-1. The vibrational frequencies and relative Raman intensities of the anti-conformer are well modelled by the DFT calculations. The bond lengths and angles obtained for the anti-conformer are also in good agreement with the crystal structure. The crystal structure of (I) is stabilised by intermolecular Csbnd H⋯O hydrogen bonds that generate a three dimensional network.

  20. Different measures of structural similarity tap different aspects of visual object processing

    DEFF Research Database (Denmark)

    Gerlach, Christian

    2017-01-01

    is examined. Both measures can account for performance differences across objects, but in different conditions. It is argued that this reflects differences between the measures in whether they tap: (i) global or local shape characteristics, and (ii) between- or within-category structural similarity....

  1. Experimental and theoretical aspects of ab initio structure determination using powder diffraction techniques

    International Nuclear Information System (INIS)

    David, W.I.F.; Johnson, M.W.; Wilson, C.C.

    1988-01-01

    Neutron powder diffraction has, over the past two decades, developed into a powerful technique for the refinement of moderately complex crystal structures. The advent of a new generation of ultra-high resolution X-ray and neutron powder diffractometers, however, not only permits the refinement of more complex materials but also opens up new areas of research. Perhaps the most exciting development in powder diffraction techniques associated with high resolution is the ab initio determination of crystal structures. This has until recently been possible, in a routine way, only by single crystal studies. The compression of three dimensions of diffraction data to the one dimension of a powder diffraction pattern leads to an unavoidable loss of information. For many, but not all, crystal symmetries high resolution minimises this loss thus allowing the intensities of a sufficient number of resolved Bragg reflections from moderately complex materials to be extracted for use in structure solution by direct methods of phase determination and by Patterson methods. Recent structure determination using the high resolution powder diffractometer, HRPD, at ISIS will be presented. The inherent limitations resulting from crystal and instrumental resolution are discussed along with maximum entropy techniques that seek to optimise the information content of a powder diffraction pattern. (author) 36 refs., 1 fig., 3 tabs

  2. Investigation of Ba2–xSrxTiO4: Structural aspects and dielectric ...

    Indian Academy of Sciences (India)

    SrTiO4 (0 ≤ ≤ 2), show that pure phases exist only for the end members, Ba2TiO4 and Sr2TiO4, crystallizing in the -K2SO4 and K2NiF4 structures, respectively. The intermediate compositions (till ≤ 1) lead to a biphasic mixture of ...

  3. Insights into the structural and functional aspects of rela by molecular modeling and docking calculations.

    Digital Repository Service at National Institute of Oceanography (India)

    Nath I.V.A.; LokaBharathi, P.A.; Deobagkar, D.D.

    in this direction are progressing. At present, no experimentally solved 3D structure is available for RelA. This was the motivation for us to conduct the present investigation. We built the hypothetical model of RelA in two Gram negative bacteria- P...

  4. Hot embossing of photonic crystal polymer structures with a high aspect ratio

    DEFF Research Database (Denmark)

    Schelb, Mauno; Vannahme, Christoph; Kolew, Alexander

    2011-01-01

    Hot embossing is a promising approach for mass production of photonic crystal structures. This paper describes the fabrication of a replication tool for two-dimensional photonic crystal patterns and its replication in substrates of poly(methylmethacrylate) (PMMA) and cyclic olefin copolymer (COC...

  5. Phase Behaviour and Structural Aspects of Ternary Clathrate Hydrate Systems. The Role of Additives

    NARCIS (Netherlands)

    Mooijer-Van den Heuvel, M.M.

    2004-01-01

    In this study an experimental and modelling approach is applied to obtain fundamental insight into the phase behaviour of ternary systems, in which clathrate hydrates are formed. Proper interpretation of the phase behaviour requires knowledge on the clathrate hydrate structure in these systems,

  6. Reliability of photogrammetry in the evaluation of the postural aspects of individuals with structural scoliosis.

    Science.gov (United States)

    Saad, Karen Ruggeri; Colombo, Alexandra Siqueira; Ribeiro, Ana Paula; João, Sílvia Maria Amado

    2012-04-01

    The purpose of this study was to investigate the reliability of photogrammetry in the measurement of the postural deviations in individuals with idiopathic scoliosis. Twenty participants with scoliosis (17 women and three men), with a mean age of 23.1 ± 9 yrs, were photographed from the posterior and lateral views. The postural aspects were measured with CorelDRAW software. High inter-rater and test-retest reliability indices were found. It was observed that with more severity of scoliosis, greater were the variations between the thoracic kyphosis and lumbar lordosis measures obtained by the same examiner from the left lateral view photographs. A greater body mass index (BMI) was associated with greater variability of the trunk rotation measures obtained by two independent examiners from the right, lateral view (r = 0.656; p = 0.002). The severity of scoliosis was also associated with greater inter-rater variability measures of trunk rotation obtained from the left, lateral view (r = 0.483; p = 0.036). Photogrammetry demonstrated to be a reliable method for the measurement of postural deviations from the posterior and lateral views of individuals with idiopathic scoliosis and could be complementarily employed for the assessment procedures, which could reduce the number of X-rays used for the follow-up assessments of these individuals. Copyright © 2011 Elsevier Ltd. All rights reserved.

  7. Structural aspects of cold-formed steel section designed as U-shape composite beam

    Science.gov (United States)

    Saggaff, Anis; Tahir, Mahmood Md.; Azimi, Mohammadamin; Alhajri, T. M.

    2017-11-01

    Composite beam construction usually associated with old-style Hot-Rolled Steel Section (HRSS) has proven to act much better in compare with Cold-Formed Steel Section (CFSS) sections due to thicker section. Due, it's getting popular to replace HRSS with CFSS in some aspects as a composite beam. The advantages such as lightweight, cost effective and easy to install have contributed to the apply CFSS as a preferred construction material for composite beam. There is a few technical data available regarding the application of the usage of CFSS as a composite system, despite the potentials use for residential and light-weight industrial constructions. This paper presents an experimental tests results which have been conducted using CFSS as composite beam. Composite action of CFSS arranged as double beam with Self-Compacting Concrete (SCC) slab are integrated together with bolted shear connectors were used. A full-scale test comprised of 3 proposed composite beam specimens with bolted shear connector spaced at 300 mm interval of grade 8.8 was using single nut with washer on flange of CFS, cast to the slab and loaded until failed. The test show that the bolted shear connector yielded better capacity of ultimate strength and ultimate moment for the proposed composite beam. It can be concluded that, bolted shear connectors of 16 mm in diameter performed better than the other diameter size of bolted shear connectors.

  8. Sequence, structure and function relationships in flaviviruses as assessed by evolutive aspects of its conserved non-structural protein domains.

    Science.gov (United States)

    da Fonseca, Néli José; Lima Afonso, Marcelo Querino; Pedersolli, Natan Gonçalves; de Oliveira, Lucas Carrijo; Andrade, Dhiego Souto; Bleicher, Lucas

    2017-10-28

    Flaviviruses are responsible for serious diseases such as dengue, yellow fever, and zika fever. Their genomes encode a polyprotein which, after cleavage, results in three structural and seven non-structural proteins. Homologous proteins can be studied by conservation and coevolution analysis as detected in multiple sequence alignments, usually reporting positions which are strictly necessary for the structure and/or function of all members in a protein family or which are involved in a specific sub-class feature requiring the coevolution of residue sets. This study provides a complete conservation and coevolution analysis on all flaviviruses non-structural proteins, with results mapped on all well-annotated available sequences. A literature review on the residues found in the analysis enabled us to compile available information on their roles and distribution among different flaviviruses. Also, we provide the mapping of conserved and coevolved residues for all sequences currently in SwissProt as a supplementary material, so that particularities in different viruses can be easily analyzed. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Structural aspects of magnetic fluid stabilization in aqueous agarose solutions

    Energy Technology Data Exchange (ETDEWEB)

    Nagornyi, A.V. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Taras Shevchenko National University of Kyiv, Kyiv (Ukraine); Petrenko, V.I., E-mail: vip@nf.jinr.ru [Joint Institute for Nuclear Research, Dubna (Russian Federation); Taras Shevchenko National University of Kyiv, Kyiv (Ukraine); Avdeev, M.V. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Yelenich, O.V.; Solopan, S.O.; Belous, A.G. [V.I.Vernadsky Institute of General and Inorganic Chemistry of the Ukrainian NAS, Kyiv (Ukraine); Gruzinov, A.Yu. [National Research Centre “Kurchatov Institute”, Moscow (Russian Federation); Ivankov, O.I. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Institute for Safety Problems of Nuclear Power Plants of the Ukrainian NAS, Kyiv (Ukraine); Bulavin, L.A. [Taras Shevchenko National University of Kyiv, Kyiv (Ukraine); Institute for Safety Problems of Nuclear Power Plants of the Ukrainian NAS, Kyiv (Ukraine)

    2017-06-01

    Structure characterization of magnetic fluids (MFs) synthesized by three different methods in aqueous solutions of agarose was done by means of small-angle neutron (SANS) and synchrotron X-ray scattering (SAXS). The differences in the complex aggregation observed in the studied magnetic fluids were related to different stabilizing procedures of the three kinds of MFs. The results of the analysis of the scattering (mean size of single polydisperse magnetic particles, fractal dimensions of the aggregates) are consistent with the data of transmission electron microscopy (TEM). - Highlights: • MFs synthesized by three different methods in agarose solution were studied. • all MFs are agglomerated colloidal systems whose structures are nevertheless stable in time. • differences in the complex aggregation were observed in the studied magnetic fluids. • results of the SAXS and SANS analysis are consistent with TEM data.

  10. Structural aspects of the interaction of dairy phages with their host bacteria.

    Science.gov (United States)

    Mahony, Jennifer; van Sinderen, Douwe

    2012-09-01

    Knowledge of phage-host interactions at a fundamental level is central to the design of rational strategies for the development of phage-resistant strains that may be applied in industrial settings. Phages infecting lactic acid bacteria, in particular Lactococcus lactis and Streptococcus thermophilus, negatively impact on dairy fermentation processes with serious economic implications. In recent years a wealth of information on structural protein assembly and topology has become available relating to phages infecting Escherichia coli, Bacillus subtilis and Lactococcus lactis, which act as models for structural analyses of dairy phages. In this review, we explore the role of model tailed phages, such as T4 and SPP1, in advancing our knowledge regarding interactions between dairy phages and their hosts. Furthermore, the potential of currently investigated dairy phages to in turn serve as model systems for this particular group of phages is discussed.

  11. Structural combination of established 5-HT(2A) receptor ligands: new aspects of the binding mode

    DEFF Research Database (Denmark)

    Kramer, Vasko; Herth, Matthias M; Santini, Martin A

    2010-01-01

    MH.MZ, MDL 100907, and altanserin are structurally similar 4-benzoyl-piperidine derivatives and are well accommodated to receptor interaction models. We combined structural elements of different high-affinity and selective 5-HT(2A) antagonists, as MH.MZ, altanserin, and SR 46349B, to improve......) with a moderate affinity toward the 5-HT(2A) receptor (K(i) = 57 nm). The remarkably reduced affinity of other compounds (4a), (4b), and (4c) (K(i) = 411, 360 and 356 nm respectively) indicates that MH.MZ can only bind to the 5-HT(2A) receptor with the p-fluorophenylethyl residue in a sterically restricted...

  12. Calorimetric Studies and Structural Aspects of Ionic Liquids in Designing Sorption Materials for Thermal Energy Storage.

    Science.gov (United States)

    Brünig, Thorge; Krekić, Kristijan; Bruhn, Clemens; Pietschnig, Rudolf

    2016-11-02

    The thermal properties of a series of twenty-four ionic liquids (ILs) have been determined by isothermal titration calorimetry (ITC) with the aim of simulating processes involving water sorption. For eleven water-free ILs, the molecular structures have been determined by X-ray crystallography in the solid state, which have been used to derive the molecular volumes of the ionic components of the ILs. Moreover, the structures reveal a high prevalence of hydrogen bonding in these compounds. A relationship between the molecular volumes and the experimentally determined energies of dilution could be established. The highest energies of dilution observed in this series were obtained for the acetate-based ILs, which underlines their potential as working fluids in sorption-based thermal energy storage systems. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Evaluation Aspects of Building Structures Reconstructed After a Failure or Catastrophe

    Science.gov (United States)

    Krentowski, Janusz R.; Knyziak, Piotr

    2017-10-01

    The article presents the characteristics of several steel structures, among others modernized industrial dye house, school sports hall, truck repair workshop, that have been rebuilt after a disaster or a catastrophe. The structures were analyzed in detail, and the evaluation and reconstruction processes were described. The emergencies that occurred during exploitation of the buildings were the result of multiple mistakes: incorrectly defined intervals between inspections, errors during periodic inspections, incorrect repair work recommendations. The concepts of reinforcement work implemented by the authors, enabling the long-term future failure-free operation of the objects, were presented. Recommendations for monitoring of the facilities, applied after reinforcement or reconstruction, have been formulated. The methodology for the implementation of specialized investigations, such as geodetic, optical, geological, chemical strength tests, both destructive and non-destructive, has been defined. The need to determine the limit values of deformations, deflections, damage or other faults of structural elements and the entire rebuilt facilities, as well as defining conditions for objects’ withdrawal from operation in subsequent exceptional situations was indicated.

  14. Structural aspects of catalytic mechanisms of endonucleases and their binding to nucleic acids

    Energy Technology Data Exchange (ETDEWEB)

    Zhukhlistova, N. E.; Balaev, V. V.; Lyashenko, A. V.; Lashkov, A. A., E-mail: alashkov83@gmail.com [Russian Academy of Sciences, Shubnikov Institute of Crystallography (Russian Federation)

    2012-05-15

    Endonucleases (EC 3.1) are enzymes of the hydrolase class that catalyze the hydrolytic cleavage of deoxyribonucleic and ribonucleic acids at any region of the polynucleotide chain. Endonucleases are widely used both in biotechnological processes and in veterinary medicine as antiviral agents. Medical applications of endonucleases in human cancer therapy hold promise. The results of X-ray diffraction studies of the spatial organization of endonucleases and their complexes and the mechanism of their action are analyzed and generalized. An analysis of the structural studies of this class of enzymes showed that the specific binding of enzymes to nucleic acids is characterized by interactions with nitrogen bases and the nucleotide backbone, whereas the nonspecific binding of enzymes is generally characterized by interactions only with the nucleic-acid backbone. It should be taken into account that the specificity can be modulated by metal ions and certain low-molecular-weight organic compounds. To test the hypotheses about specific and nonspecific nucleic-acid-binding proteins, it is necessary to perform additional studies of atomic-resolution three-dimensional structures of enzyme-nucleic-acid complexes by methods of structural biology.

  15. Structural aspects of crotoxin modified by ionizing radiation; Aspectos estruturais da crotoxina modificada pela radiacao ionizante

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Karina Corleto de; Albero, Felipe Guimaraes; Zezell, Denise Maria; Spencer, Patrick Jack; Nascimento, Nanci do, E-mail: kcorleto@usp.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2010-03-15

    Ionizing radiation has proven to be an excellent tool for reducing the toxicity of venoms and isolated toxins, resulting in better immunogens for serum production, the only effective treatment in case of snake bites, and contributing to the welfare of serum-producing animals. Since the action of gamma radiation of venoms and toxins has not been yet fully clarified from the structural point of view, we proposed in this paper, to characterize the crotoxin, a venom protein of the species Crotalus durissus terrificus by Circular Dichroism (CD) and Infrared Spectroscopy (FTIR) techniques. After chromatographic techniques, crotoxin was irradiated with 2.0 kGy ({sup 60}Co source). The CD spectra obtained of native and irradiated crotoxin solutions showed changes between the samples in characteristic regions of -sheet and-helix . The Infrared analyse showed expressive changes in the spectra of the native and irradiated crotoxin (amide I band region). These tests showed that crotoxin when subjected to gamma radiation, showed changes in their structural conformation compared with the samples in the native state. Such changes probably occur in the secondary structure and may explain its neurotoxic activity loss. (author)

  16. Some aspects of floor spectra of 1DOF nonlinear primary structures

    International Nuclear Information System (INIS)

    Politopoulos, I.; Feau, C.

    2007-01-01

    In this paper the influence of the nonlinear behaviour of the primary structure on floor spectra is investigated by means of simple models. The general trends of floor spectra for different types of nonlinear behaviour of one degree of freedom (1DOF) primary structure are shown and we point out their common futures and their differences. A special attention is given to the cases of elastoplastic and nonlinear elastic behaviours and methods to determine an equivalent linear oscillator are proposed. The properties (frequency and damping) of this equivalent linear oscillator are quite different from the properties of equivalent linear oscillators commonly considered in practice. In particular, in the case of elastoplastic behaviour, there is no frequency shift and damping is smaller than assumed by other methods commonly used. In the case of nonlinear elastic behaviour, the concept of an equivalent frequency which is a random variable is used. Finally, a design floor spectrum of primary structures, exhibiting energy dissipating nonlinear behaviour is proposed. (authors)

  17. Some physical problems in biology: Aspects of the origin and structure of the first cell

    International Nuclear Information System (INIS)

    Chela Flores, J.

    1995-01-01

    A review is presented within the framework of the theory of evolution, after it has been extrapolated from the population level to the cellular and molecular levels. From Darwin's seminal and persuasive insight - the theory of common descent - we assume, with him, that ''probably all the organic beings which have ever lived on this earth have descended from some one primordial form, into which life was first breathed''. We are now aware that his primordial cell may have been a protocyanobacterium, but it has often been called 'a last universal ancestor', a 'breakthrough organism', or a 'progenote', a term introduced by Woese which has gained wide acceptance. Strictly speaking, in the 'intermediate period', ranging from the first living cell to the progenote, life may have evolved in the absence of significant diversity, effectively as a single phylum, incorporating organisms whose genetic systems were already based on DNA. Earlier still, prior to the encapsulation of nucleic acids in microspheres, evolution may already have been at work on RNA molecules (the 'RNA world'). This takes our discussion into the period of chemical evolution, a concept first put forward by Oparin, whose principal merit is to have formulated the underlying problem in clear scientific terms. This review does not attempt to be comprehensive. It is mainly devoted to the discussion of certain concepts that may have played a relevant role in the pathway that led to the origin and evolution of the progenote. We do not dwell on the main events of the intermediate period. The topic that we have chosen to include are: the origin of chirality of protein amino acids, the origin of translation, and the origin of the genome. We conclude with some comments on one further aspect of the evolutionary process - the development of biodiversity - by considering the origin of the first eukaryotic cell, an event which, according to the fossil record, may have preceded the evolutionary radiation in the early

  18. The Serra da Cangalha impact structure, Brazil: Geological, stratigraphic and petrographic aspects of a recently confirmed impact structure

    Science.gov (United States)

    Vasconcelos, Marcos Alberto Rodrigues; Crósta, Alvaro P.; Reimold, Wolf Uwe; Góes, Ana Maria; Kenkmann, Thomas; Poelchau, Michael H.

    2013-08-01

    Serra da Cangalha is a complex impact structure with an apparent diameter of 13.7 km located in essentially undisturbed sedimentary rocks of the Parnaíba basin in northeastern Brazil. The stratigraphy of the crater region includes, from bottom to top, the Longá, Poti, Piauí and Pedra de Fogo formations of Devonian to Late Permian age. The age of the impact event is constrained to collar of Poti Formation rocks. We divided Serra da Cangalha into four distinctive structural domains (i-iv), from the innermost zone outward. (i) The central domain, with an inner collar ˜1.5 km radius from the center, yielded all the samples with microscopic shock features identified so far. These include planar deformation features (PDF), feather features (FF), and planar fractures (PF) in quartz grains found in polymict breccias and shatter cones from the central depression. Furthermore, significant cementation with iron oxide is observed in the rocks of Serra da Cangalha, especially in the Poti Formation and in the polymict breccias, conferring to them a peculiar red color. Macroscopic deformation involves faulted, folded and subvertical strata within a ˜2.9 km radius from the center. (ii) The annular basin domain has limited outcrops; its most prominent features are two concentric annular ridges formed by chert breccias and fossilized wood-bearing folded strata of the Pedra de Fogo Formation. (iii) The crater rim and (iv) external domains comprise undisturbed strata of the Pedra de Fogo and Piauí formations with well-preserved sedimentary structures. Whilst the existing literature on Serra da Cangalha has focused on the structure morphology, general geology and some shock features, we present here a detailed description of the stratigraphy and the geology of each formation in the interior and around Serra da Cangalha, as well as further detailed microscopic shock feature analysis. This provides significant evidence that the rocks of the central uplift have undergone shock

  19. Selected aspects of GDP value and structure development in sub-Saharan Africa

    Directory of Open Access Journals (Sweden)

    Luboš Smutka

    2011-01-01

    Full Text Available Africa belongs to the poorest regions of the world. This statement may be applied especially to its sub-Saharan part. The paper analyses some basic structural characteristics related to the economic development of sub-Saharan region. The article reveals existing differences between countries and regions of sub-Saharan Africa and analyses key problems which influence economic development of individual states. An emphasis is placed on analysing an unsuitable GDP structure and on external economic relations which affect this structure. Results of an investigation show that the GDP of sub-Saharan countries is to a large extend generated by the primary sector of their economies, which is dominant in the total GDP value and its position is continuously strengthening due to a high dynamics of its growth. Having regard to the external environment, there can be stated that the foreign trade has contributed to the GDP growth of the whole region only to a limited degree (this does not apply to all countries seen as individuals. The integration process in sub-Saharan Africa may be characterized as questionable. Many integration groupings are operating in the region, but their influence on economic growth is limited due a low potential for mutual cooperation based on specialisation and use of comparative advantages. The economies of sub-Saharan countries are very sensitive to changes in their external economic environment. In this regard, there is important to highlight the very strong sensitivity of the GDP in the sub-Saharan region in relation to the World GDP (mainly to European and US GDP because both regions belong to the most important trading partners of Africa as a whole.

  20. Structural Aspects for Evolution of [beta]-Lactamases from Penicillin-Binding Proteins

    Energy Technology Data Exchange (ETDEWEB)

    Meroueh, Samy O.; Minasov, George; Lee, Wenlin; Shoichet, Brian K.; Mobashery, Shahriar (NWU); (UCSF); (Notre)

    2010-03-08

    Penicillin-binding proteins (PBPs), biosynthetic enzymes of bacterial cell wall assembly, and {beta}-lactamases, resistance enzymes to {beta}-lactam antibiotics, are related to each other from an evolutionary point of view. Massova and Mobashery (Antimicrob. Agents Chemother. 1998, 42, 1-17) have proposed that for {beta}-lactamases to have become effective at their function as antibiotic resistance enzymes, they would have had to undergo structure alterations such that they would not interact with the peptidoglycan, which is the substrate for PBPs. A cephalosporin analogue, 7{beta}-[N-Acetyl-L-alanyl-{gamma}-D-glutamyl-L-lysine]-3-acetoxymethyl-3-cephem-carboxylic acid (compound 6), was conceived and synthesized to test this notion. The X-ray structure of the complex of this cephalosporin bound to the active site of the deacylation-deficient Q120L/Y150E variant of the class C AmpC {beta}-lactamase from Escherichia coli was solved at 1.71 {angstrom} resolution. This complex revealed that the surface for interaction with the strand of peptidoglycan that acylates the active site, which is present in PBPs, is absent in the {beta}-lactamase active site. Furthermore, insertion of a peptide in the {beta}-lactamase active site at a location where the second strand of peptidoglycan in some PBPs binds has effectively abolished the possibility for such interaction with the {beta}-lactamase. A 2.6 ns dynamics simulation was carried out for the complex, which revealed that the peptidoglycan surrogate (i.e., the active-site-bound ligand) undergoes substantial motion and is not stabilized for binding within the active site. These factors taken together disclose the set of structure modifications in the antibiotic resistance enzyme that prevent it from interacting with the peptidoglycan, en route to achieving catalytic proficiency for their intended function.

  1. Structural and functional aspects of the multidrug efflux pump AcrB.

    Science.gov (United States)

    Eicher, Thomas; Brandstätter, Lorenz; Pos, Klaas M

    2009-08-01

    The tripartite efflux system AcrA/AcrB/TolC is the main pump in Escherichia coli for the efflux of multiple antibiotics, dyes, bile salts and detergents. The inner membrane component AcrB is central to substrate recognition and energy transduction and acts as a proton/drug antiporter. Recent structural studies show that homotrimeric AcrB can adopt different monomer conformations representing consecutive states in an allosteric functional rotation transport cycle. The conformational changes create an alternate access drug transport tunnel including a hydrophobic substrate binding pocket in one of the cycle intermediates.

  2. Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products.

    Science.gov (United States)

    Al Toma, Rashed S; Brieke, Clara; Cryle, Max J; Süssmuth, Roderich D

    2015-08-01

    Phenylglycine-type amino acids occur in a wide variety of peptide natural products, including glycopeptide antibiotics and biologically active linear and cyclic peptides. Sequencing of biosynthesis gene clusters of chloroeremomycin, balhimycin and pristinamycin paved the way for intensive investigations on the biosynthesis of 4-hydroxyphenylglycine (Hpg), 3,5-dihydroxyphenylglycine (Dpg) and phenylglycine (Phg) in recent years. The significance and importance of this type of unusual non-proteinogenic aromatic amino acids also for medicinal chemistry has drawn the attention of many research groups and pharmaceutical companies. Herein structures and properties of phenylglycine containing natural products as well as the biosynthetic origin and incorporation of phenylglycines are discussed.

  3. Structural aspects of HDAC8 mechanism and dysfunction in Cornelia de Lange syndrome spectrum disorders.

    Science.gov (United States)

    Deardorff, Matthew A; Porter, Nicholas J; Christianson, David W

    2016-11-01

    Cornelia de Lange Syndrome (CdLS) encompasses a broad spectrum of phenotypes characterized by distinctive craniofacial abnormalities, limb malformations, growth retardation, and intellectual disability. CdLS spectrum disorders are referred to as cohesinopathies, with ∼70% of patients having a mutation in a gene encoding a core cohesin protein (SMC1A, SMC3, or RAD21) or a cohesin regulatory protein (NIPBL or HDAC8). Notably, the regulatory function of HDAC8 in cohesin biology has only recently been discovered. This Zn 2+ -dependent hydrolase catalyzes the deacetylation of SMC3, a necessary step for cohesin recycling during the cell cycle. To date, 23 different missense mutants in the gene encoding HDAC8 have been identified in children with developmental features that overlap those of CdLS. Enzymological, biophysical, and structural studies of CdLS HDAC8 protein mutants have yielded critical insight on compromised catalysis in vitro. Most CdLS HDAC8 mutations trigger structural changes that directly or indirectly impact substrate binding and catalysis. Additionally, several mutations significantly compromise protein thermostability. Intriguingly, catalytic activity in many HDAC8 mutants can be partially or fully restored by an N-acylthiourea activator, suggesting a plausible strategy for the chemical rescue of compromised HDAC8 catalysis in vivo. © 2016 The Protein Society.

  4. Aspects of structural health and condition monitoring of offshore wind turbines

    Science.gov (United States)

    Antoniadou, I.; Dervilis, N.; Papatheou, E.; Maguire, A. E.; Worden, K.

    2015-01-01

    Wind power has expanded significantly over the past years, although reliability of wind turbine systems, especially of offshore wind turbines, has been many times unsatisfactory in the past. Wind turbine failures are equivalent to crucial financial losses. Therefore, creating and applying strategies that improve the reliability of their components is important for a successful implementation of such systems. Structural health monitoring (SHM) addresses these problems through the monitoring of parameters indicative of the state of the structure examined. Condition monitoring (CM), on the other hand, can be seen as a specialized area of the SHM community that aims at damage detection of, particularly, rotating machinery. The paper is divided into two parts: in the first part, advanced signal processing and machine learning methods are discussed for SHM and CM on wind turbine gearbox and blade damage detection examples. In the second part, an initial exploration of supervisor control and data acquisition systems data of an offshore wind farm is presented, and data-driven approaches are proposed for detecting abnormal behaviour of wind turbines. It is shown that the advanced signal processing methods discussed are effective and that it is important to adopt these SHM strategies in the wind energy sector. PMID:25583864

  5. Intercalation and structural aspects of macroRAFT agents into MgAl layered double hydroxides

    Directory of Open Access Journals (Sweden)

    Dessislava Kostadinova

    2016-12-01

    Full Text Available Increasing attention has been devoted to the design of layered double hydroxide (LDH-based hybrid materials. In this work, we demonstrate the intercalation by anion exchange process of poly(acrylic acid (PAA and three different hydrophilic random copolymers of acrylic acid (AA and n-butyl acrylate (BA with molar masses ranging from 2000 to 4200 g mol−1 synthesized by reversible addition-fragmentation chain transfer (RAFT polymerization, into LDH containing magnesium(II and aluminium(III intralayer cations and nitrates as counterions (MgAl-NO3 LDH. At basic pH, the copolymer chains (macroRAFT agents carry negative charges which allowed the establishment of electrostatic interactions with the LDH interlayer and their intercalation. The resulting hybrid macroRAFT/LDH materials displayed an expanded interlamellar domain compared to pristine MgAl-NO3 LDH from 1.36 nm to 2.33 nm. Depending on the nature of the units involved into the macroRAFT copolymer (only AA or AA and BA, the intercalation led to monolayer or bilayer arrangements within the interlayer space. The macroRAFT intercalation and the molecular structure of the hybrid phases were further characterized by Fourier transform infrared (FTIR and solid-state 13C, 1H and 27Al nuclear magnetic resonance (NMR spectroscopies to get a better description of the local structure.

  6. Nuclear structure and nuclear reaction aspects of Faessler and Greiner's rotation-vibration coupling theory

    International Nuclear Information System (INIS)

    Aspelund, O.

    In the nuclear structure part, the foundations of Faessler and Greiner's rotation-vibration coupling theory are reviewed, whereafter an alternative derivation of Faessler and Greiner's Hamiltonian is presented. A non-spherical quadrupole phonon number N is defined and used in the matrix elements reported for odd-even/even-odd nuclei. These matrix elements are shown to evince oblate-prolate effects that can be exploited for assessing the signs of quadrupole deformations. In the nuclear reaction part, the wave functions emerging from the structure part are applied in a complete and consistent description of elastic and inelastic particle scattering, one-nucleon transfer, and particle/γ-ray angular correlations. The intentions are to demonstrate that anomolous angular distributions and 1=2 j-effects observed in one-nucleon transfer are interrelated phenomena, that can be satisfactorily explained in terms of the elementary vibrational excitation modes inherent in Faessler and Greiner's theory. The latter is regarded as a non-spherical approach to the theory of the quadrupole component of the nuclear potential energy surface. (Auth.)

  7. The static structure factor of liquid 4He: some new aspects

    International Nuclear Information System (INIS)

    Khalil, K.Y.

    1986-08-01

    The thesis is concerned with three complementary problems. The first deals with a new interpretation of the elusive nature of the roton. This is motivated by the observation that the 'rotonic' minimum in the dispersion curve, which is intimately related to the principal peak of the static structure factor, is a common feature not only for He II but also for He I and almost all other condensed systems. The second problem concerns the precise asymptotic behaviour of the pair correlation function for liquid sup 4 He, whose Fourier transform is essentially the long-wavelength liquid structure factor. The third problem deals with the implications of this new formulation as related to Bose-Einstein condensation and superfluidity, as well as to other physical properties of the system. The thesis concludes with a partial list of open problems and with two possible extensions, including a complete development of an exceedingly simple method for determining the second virial coefficient of the sup 4 He gas over a wide temperature range. 122 refs., 2 figs., 5 tabs. (A.M.H)

  8. Structural Aspects of the Interaction of Dairy Phages with Their Host Bacteria

    Directory of Open Access Journals (Sweden)

    Jennifer Mahony

    2012-08-01

    Full Text Available Knowledge of phage-host interactions at a fundamental level is central to the design of rational strategies for the development of phage-resistant strains that may be applied in industrial settings. Phages infecting lactic acid bacteria, in particular Lactococcus lactis and Streptococcus thermophilus, negatively impact on dairy fermentation processes with serious economic implications. In recent years a wealth of information on structural protein assembly and topology has become available relating to phages infecting Escherichia coli, Bacillus subtilis and Lactococcus lactis, which act as models for structural analyses of dairy phages. In this review, we explore the role of model tailed phages, such as T4 and SPP1, in advancing our knowledge regarding interactions between dairy phages and their hosts. Furthermore, the potential of currently investigated dairy phages to in turn serve as model systems for this particular group of phages is discussed.

  9. STRUCTURAL ASPECTS OF STRONG INHIBITION AND ROLE OF SCAFFOLD FOR SERINE PROTEASE INHIBITORS

    Directory of Open Access Journals (Sweden)

    Jhimli Dasgupta

    2011-12-01

    Full Text Available Canonical serine protease inhibitors inhibit their cognate enzymes by binding tightly at the enzyme active site in a substrate-like manner, being cleaved extremely slowly compared to a true substrate. They interact with cognate enzymes through P3-P2 region of the inhibitory loop while the scaffold hardly makes any contact. Neighbouring scaffolding residues like arginine or asparagine shape-up the inhibitory loop and religate the cleaved scissile bond. The specificity of the inhibitor can be altered by mutating the hyper solvent accessible P1 residue without changing loop-scaffold interactions. To understand the loop-scaffold compatibility, we prepared three chimeric proteins ECIL-WCIS , ETIL-WCIS , and STIL-WCIS , where the inhibitory loops of ECI, ETI, and STI were placed on the scaffold of their homologue WCI. Results showed that although ECIL-WCIS and STIL-WCIS behave like inhibitors, ETIL-WCIS behaves like a substrate. Crystal structure of ETIL-WCIS and its comparison with ETI indicated that three novel scaffolding residues Trp88, Arg74, and Tyr113 in ETI act as barrier to confine the inhibitory loop to canonical conformation. Absence of this barrier in the scaffold of WCI makes the inhibitory loop flexible in ETIL-WCIS leading to a loss of canonical conformation, explaining its substrate-like behaviour. Furthermore, complex structures of the inhibitors with their cognate enzymes indicate that rigidification of the inhibitory loop at the enzyme active site is necessary for efficient inhibition.

  10. Leaf colleters in Tontelea micrantha (Celastraceae, Salacioideae): ecological, morphological and structural aspects.

    Science.gov (United States)

    Mercadante-Simões, Maria Olívia; Paiva, Elder Antônio Sousa

    2013-08-01

    The colleter secretion can be useful to protect plants of Cerrado (Brazilian savanna) biome during the long and pronounced dry season. This study describes the presence of colleters in Tontelea micrantha and represents the first record of these structures in Celastraceae. To investigate colleter structure and their secretory processes, young leaves were collected, fixed, and processed according to conventional techniques for light, and electron microscopy. Colleters were observed at the marginal teeth on the leaf. They produce mucilaginous secretions that spread over the leaf surface. After secretory phase, colleters abscise. The secretory epithelium is uniseriate and composed of elongated cells whose dense cytoplasm is rich in organelles. The ultrastructure of the secretory cells is compatible with the pectin-rich secretion. Observations of the young leaves surface revealed the presence of superficial hydrophilic secretion films that appeared to have the function of maintaining the water status of those organs. Copyright © 2013 Académie des sciences. Published by Elsevier SAS. All rights reserved.

  11. Aspects of structural health and condition monitoring of offshore wind turbines.

    Science.gov (United States)

    Antoniadou, I; Dervilis, N; Papatheou, E; Maguire, A E; Worden, K

    2015-02-28

    Wind power has expanded significantly over the past years, although reliability of wind turbine systems, especially of offshore wind turbines, has been many times unsatisfactory in the past. Wind turbine failures are equivalent to crucial financial losses. Therefore, creating and applying strategies that improve the reliability of their components is important for a successful implementation of such systems. Structural health monitoring (SHM) addresses these problems through the monitoring of parameters indicative of the state of the structure examined. Condition monitoring (CM), on the other hand, can be seen as a specialized area of the SHM community that aims at damage detection of, particularly, rotating machinery. The paper is divided into two parts: in the first part, advanced signal processing and machine learning methods are discussed for SHM and CM on wind turbine gearbox and blade damage detection examples. In the second part, an initial exploration of supervisor control and data acquisition systems data of an offshore wind farm is presented, and data-driven approaches are proposed for detecting abnormal behaviour of wind turbines. It is shown that the advanced signal processing methods discussed are effective and that it is important to adopt these SHM strategies in the wind energy sector.

  12. Fundamental aspects of the structural and electrolyte properties of Li2OHCl from simulations and experiment

    Science.gov (United States)

    Howard, Jason; Hood, Zachary D.; Holzwarth, N. A. W.

    2017-12-01

    Solid-state electrolytes that are compatible with high-capacity electrodes are expected to enable the next generation of batteries. As a promising example, Li2OHCl was reported to have good ionic conductivity and to be compatible with a lithium metal anode even at temperatures above 100 ∘C . In this work, we explore the fundamental properties of Li2OHCl by comparing simulations and experiments. Using calculations based on density functional theory, including both static and dynamic contributions through the quasiharmonic approximation, we model a tetragonal ground state, which is not observed experimentally. An ordered orthorhombic low-temperature phase was also simulated, agreeing with experimental structural analysis of the pristine electrolyte at room temperature. In addition, comparison of the ordered structures with simulations of the disordered cubic phase provide insight into the mechanisms associated with the experimentally observed abrupt increase in ionic conductivity as the system changes from its ordered orthorhombic to its disordered cubic phase. A large Haven ratio for the disordered cubic phase is inferred from the computed tracer diffusion coefficient and measured ionic conductivity, suggesting highly correlated motions of the mobile Li ions in the cubic phase of Li2OHCl . We find that the OH bond orientations participate in gating the Li ion motions which might partially explain the predicted Li-Li correlations.

  13. Kinetics and structural aspects of the cisplatin interactions with guanine: A quantum mechanical description

    Science.gov (United States)

    Costa, Luiz Antônio S.; Hambley, Trevor W.; Rocha, Willian R.; Almeida, Wagner B. De; Dos Santos, Hélio F.

    The interaction of cisplatin with guanine DNA bases has been investigated using ab initio Hartree-Fock (HF) and density functional levels of theory in gas phase and aqueous solution. The overall process was divided into three steps: the reaction of the monoaqua [Pt(NH3)2Cl(H2O)]+ species with guanine (G) (reaction 1), the hydrolysis process yielding the adduct [Pt(NH3)2(G) (H2O)]2+ (reaction 2) and the reaction with a second guanine leading to the product [Pt(NH3)2(G)2]2+ (reaction 3). The functionals B3LYP, BHandH, and mPW1PW91 were used in the present study, to develop an understanding of the role of the distinct models. The geometries presented for the intermediate structures were obtained by IRC calculations from the transition state structure for each reaction. The structural analysis for the intermediates and transition states showed that hydrogen bonds with the guanine O6 atom play an important role in stabilizing these species. The geometries were not very sensitive to the level of theory applied with the HF level, giving a satisfactory overall performance. However, the energy barriers and the rate constants were found to be strongly dependent on the level of calculation and basis set, with the DFT calculations giving more accurate results. For reaction 1 the rate constant calculated in aqueous solution at PCM-BHandH/6-311G* (k1 = 7.55 × 10-1 M-1 s-1) was in good agreement with the experiment (5.4 × 10-1 M-1 s-1). The BHandH/6-31G* calculated gas phase rate constants for reactions 2 and 3 were: k2 = 0.9 × 10-6 M-1 s-1 and k3 = 2.99 × 10-4 M-1 s-1 in fairly good accordance with the experimental findings for reaction 2 (1.0 × 10-6 M-1 s-1) and reaction 3 (3.0 × 10-4 M-1 s-1).

  14. Financial aspects of a seismic base isolation system for a steel high-rack structure

    Directory of Open Access Journals (Sweden)

    Kilar, V.

    2013-12-01

    Full Text Available The paper deals with the effects and costs of implementing a base isolation system for the mitigation of the seismic risk of an existing steel rack structure. Different realistic distributions of the payload mass and occupancy levels, which form different plan asymmetric variants, have been analysed. The results obtained by the pushover analysis (N2 method are presented as top floor envelopes and as plastic hinge damage patterns. In the presented cost study, the cost of the implementation of the proposed base isolation system is compared with the estimated costs of structural repairs to the damaged structural members of the superstructure, as well as with estimated expenses of the downtime period. The results have shown that base isolation is, in general, not economically feasible for lower ground motion intensities, whereas it could be of great benefit in the case of moderate and high intensities, especially if the downtime period is taken into account.El presente artículo trata sobre los efectos y costes de implementación de un sistema de aislamiento en cimentación para la mitigación del riesgo sísmico de la estructura de un bastidor de acero en altura prexistente. Se han analizado diferentes distribuciones realistas de la masa contribuyente y de los niveles de ocupación, conformando diferentes variantes asimétricas en planta. Se presentan los resultados obtenidos mediante el método N2 (análisis estático incremental no lineal como envolventes de las plantas superiores y como patrones de deterioro en estado plástico. En el estudio de costos presentado, el coste de implementación del sistema de aislamiento propuesto se compara con los costes estimados de reparación de los elementos superestructurales y los costes derivados del período de desocupación. Los resultados muestran que, en general, el aislamiento en la base no resulta viable económicamente para movimientos de baja intensidad, pero puede ser muy beneficioso en el caso de

  15. Structural Aspects of Railway Truss Bridges Affecting Transverse Shear Forces in Steel-Concrete Composite Decks

    Directory of Open Access Journals (Sweden)

    Siekierski Wojciech

    2015-03-01

    Full Text Available At the steel-concrete interface, the horizontal shear forces that are transverse to cross beams occur due to joint action of the steel-concrete composite deck and the truss girders. Numerical analysis showed that values of the forces are big in comparison to the longitudinal shear forces. In both cases extreme force values occur near side edges of a slab. The paper studies possibilities of reduction of these shear forces by structural alterations of the following: rigidity of a concrete slab, arrangement of a wind bracing, arrangement of concrete slab expansion joints. An existing railway truss bridge span has been analysed. Numerical analysis shows that it is possible to reduce the values of shear forces transverse to cross beams. It may reach 20% near the side edges of slabs and 23% in the centre of slab width.

  16. Structural and topological aspects of borophosphate glasses and their relation to physical properties

    DEFF Research Database (Denmark)

    Hermansen, Christian; Youngman, R.E.; Wang, J.

    2015-01-01

    We establish a topological model of alkali borophosphate and calcium borophosphate glasses that describes both the effect of the network formers and network modifiers on physical properties. We show that the glass transition temperature (Tg), Vickers hardness (HV), liquid fragility (m) and isobaric....... The origin of the effect of the type of network modifying oxide on Tg, HV, m and ΔCp of calcium borophosphate glasses is revealed in terms of the modifying ion sub-network. The same topological principles quantitatively explain the significant differences in physical properties between the alkali...... and the calcium borophosphate glasses. This work has implications for quantifying structure-property relations in complex glass forming systems containing several types of network forming and modifying oxides....

  17. Aspects of second-order analysis of structured inhomogeneous spatio-temporal processes

    DEFF Research Database (Denmark)

    Møller, Jesper; Ghorbani, Mohammad

    2012-01-01

    Statistical methodology for spatio-temporal point processes is in its infancy. We consider second-order analysis based on pair correlation functions and K-functions for general inhomogeneous spatio-temporal point processes and for inhomogeneous spatio-temporal Cox processes. Assuming spatio......-temporal separability of the intensity function, we clarify different meanings of second-order spatio-temporal separability. One is second-order spatio-temporal independence and relates to log-Gaussian Cox processes with an additive covariance structure of the underlying spatio-temporal Gaussian process. Another...... concerns shot-noise Cox processes with a separable spatio-temporal covariance density. We propose diagnostic procedures for checking hypotheses of second-order spatio-temporal separability, which we apply on simulated and real data....

  18. Aspects of gene structure and functional regulation of the isozymes of Na,K-ATPase

    DEFF Research Database (Denmark)

    Jorgensen, P.L.

    2001-01-01

    Gaps in our understanding of the complex regulated expression of isozymes of Na,K-ATPase and the diverse systems for posttranslational modification and short term regulation of active Na,K-transport in animals and humans are the main problems in comprehensive Na,K-pump physiology. In mammalian...... genomes, the genes of four alpha-subunit and at least three beta-subunit isoforms of Na,K-ATPase are identified and two gamma-subunits are expressed in kidney. The isoforms combine in a number of Na,K-ATPase isozymes that are expressed in a tissue and cell specific manner. Models of the molecular...... mechanism of regulation of these isozymes have become more reliable due to progress in understanding the three-dimensional protein structure and conformational transitions mediating transfer of energy from the P-domain to intramembrane Na+ and K+ binding sites....

  19. Structural and evolutionary aspects of antenna chromophore usage by class II photolyases.

    Science.gov (United States)

    Kiontke, Stephan; Gnau, Petra; Haselsberger, Reinhard; Batschauer, Alfred; Essen, Lars-Oliver

    2014-07-11

    Light-harvesting and resonance energy transfer to the catalytic FAD cofactor are key roles for the antenna chromophores of light-driven DNA photolyases, which remove UV-induced DNA lesions. So far, five chemically diverse chromophores have been described for several photolyases and related cryptochromes, but no correlation between phylogeny and used antenna has been found. Despite a common protein topology, structural analysis of the distantly related class II photolyase from the archaeon Methanosarcina mazei (MmCPDII) as well as plantal orthologues indicated several differences in terms of DNA and FAD binding and electron transfer pathways. For MmCPDII we identify 8-hydroxydeazaflavin (8-HDF) as cognate antenna by in vitro and in vivo reconstitution, whereas the higher plant class II photolyase from Arabidopsis thaliana fails to bind any of the known chromophores. According to the 1.9 Å structure of the MmCPDII·8-HDF complex, its antenna binding site differs from other members of the photolyase-cryptochrome superfamily by an antenna loop that changes its conformation by 12 Å upon 8-HDF binding. Additionally, so-called N- and C-motifs contribute as conserved elements to the binding of deprotonated 8-HDF and allow predicting 8-HDF binding for most of the class II photolyases in the whole phylome. The 8-HDF antenna is used throughout the viridiplantae ranging from green microalgae to bryophyta and pteridophyta, i.e. mosses and ferns, but interestingly not in higher plants. Overall, we suggest that 8-hydroxydeazaflavin is a crucial factor for the survival of most higher eukaryotes which depend on class II photolyases to struggle with the genotoxic effects of solar UV exposure. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  20. Fundamental structural aspects and features in the bioengineering of the gas exchangers: comparative perspectives.

    Science.gov (United States)

    Maina, J N

    2002-01-01

    Over its life, an organism's survival and success are determined by the inventory of vital adaptations that its progenitors have creatively appropriated, devised and harnessed along the evolutionary pathway. Such conserved attributes provide the armamentarium necessary for withstanding the adverse effects of natural selection. Refinements of the designs of the respiratory organs have been critical for survival and phylogenetic advancement of animal life. Gas exchangers have changed in direct response to the respiratory needs of whole organisms in different environmental states and conditions. Nowhere else is the dictum that in biology 'there are no rules but only necessities' more manifest than in the evolutionary biology of the gas exchangers. The constructions have been continually fashioned and refined to meet specific needs. Solutions to common respiratory needs have been typified by profound structural convergence. Over the evolutionary continuum, as shifts in environmental situations occurred, infinitely many designs should theoretically have emerged. Moreover, without specific selective pressures and preference for certain designs, considering that there are only two naturally occurring respirable fluid media (air and water), air-lungs, water-lungs, air-gills and water-gills would have formed to similar extents. Factors such as body size, phylogenetic level of development, respiratory medium utilized and habitats occupied have permutatively prescribed the design of the gas exchangers. The construction of the modern gas exchangers has eventuated through painstaking cost-benefit analysis. Trade-offs and compromises have decreed only a limited number of structurally feasible and functionally competent outcomes. The morphological congruity (analogy) of the gas exchangers indicates that similar selective pressures have compelled the designs. Solutions to metabolic demands for molecular O2 have only differed in details. Passive physical diffusion, for example, is

  1. Data fusion in medical imaging: merging multimodal and multipatient images, identification of structures and 3D display aspects.

    Science.gov (United States)

    Barillot, C; Lemoine, D; Le Briquer, L; Lachmann, F; Gibaud, B

    1993-06-01

    Data fusion in medical imaging can be seen into two ways (i) multisensors fusion of anatomical and functional information and (ii) interpatient data fusion by means of warping models. These two aspects set the methodological framework necessary to perform anatomical modelling especially when concerning the modelling of brain structures. The major relevance of the work presented here concerns the interpretation of multimodal 3D neuro-anatomical data bases. Three types of data fusion problems are considered in this paper. The first one concerns the problem of data combination which includes multimodal registration (multisensor fusion applied to CT, MRI, DSA, PET, SPECT, or MEG). In particular, the problem of warping patient data to an anatomical atlas is reviewed and a solution is proposed. The second problem of data fusion addressed in this paper is the identification of anatomical structures by means of image analysis methods. Two techniques have been developed. The first one deals with the analysis of image geometrical features to end up with the determination of a fuzzy mask to label the structure of interest. The second technique consists of labelling major cerebral structures by means of statistical image features associated with relaxation techniques. Finally, the paper presents a review of up to date 3D display techniques with a special emphasis on volume rendering and 3D display of combined data.

  2. Framework for Structural Online Health Monitoring of Aging and Degradation of Secondary Systems due to some Aspects of Erosion

    International Nuclear Information System (INIS)

    Gribok, Andrei; Patnaik, Sobhan; Williams, Christian; Pattanaik, Marut; Kanakala, Raghunath

    2016-01-01

    This report describes the current state of research related to critical aspects of erosion and selected aspects of degradation of secondary components in nuclear power plants. The report also proposes a framework for online health monitoring of aging and degradation of secondary components. The framework consists of an integrated multi-sensor modality system which can be used to monitor different piping configurations under different degradation conditions. The report analyses the currently known degradation mechanisms and available predictive models. Based on this analysis, the structural health monitoring framework is proposed. The Light Water Reactor Sustainability Program began to evaluate technologies that could be used to perform online monitoring of piping and other secondary system structural components in commercial NPPs. These online monitoring systems have the potential to identify when a more detailed inspection is needed using real-time measurements, rather than at a pre-determined inspection interval. This transition to condition-based, risk informed automated maintenance will contribute to a significant reduction of operations and maintenance costs that account for the majority of nuclear power generation costs. There is unanimous agreement between industry experts and academic researchers that identifying and prioritizing inspection locations in secondary piping systems (for example, in raw water piping or diesel piping) would eliminate many excessive in-service inspections. The proposed structural health monitoring framework takes aim at answering this challenge by combining long-range guided wave technologies with other monitoring techniques, which can significantly increase the inspection length and pinpoint the locations that degraded the most. More widely, the report suggests research efforts aimed at developing, validating, and deploying online corrosion monitoring techniques for complex geometries, which are pervasive in NPPs.

  3. Framework for Structural Online Health Monitoring of Aging and Degradation of Secondary Systems due to some Aspects of Erosion

    Energy Technology Data Exchange (ETDEWEB)

    Gribok, Andrei [Idaho National Lab. (INL), Idaho Falls, ID (United States); Patnaik, Sobhan [Idaho National Lab. (INL), Idaho Falls, ID (United States); Williams, Christian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Pattanaik, Marut [Idaho National Lab. (INL), Idaho Falls, ID (United States); Kanakala, Raghunath [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-09-01

    This report describes the current state of research related to critical aspects of erosion and selected aspects of degradation of secondary components in nuclear power plants. The report also proposes a framework for online health monitoring of aging and degradation of secondary components. The framework consists of an integrated multi-sensor modality system which can be used to monitor different piping configurations under different degradation conditions. The report analyses the currently known degradation mechanisms and available predictive models. Based on this analysis, the structural health monitoring framework is proposed. The Light Water Reactor Sustainability Program began to evaluate technologies that could be used to perform online monitoring of piping and other secondary system structural components in commercial NPPs. These online monitoring systems have the potential to identify when a more detailed inspection is needed using real-time measurements, rather than at a pre-determined inspection interval. This transition to condition-based, risk informed automated maintenance will contribute to a significant reduction of operations and maintenance costs that account for the majority of nuclear power generation costs. There is unanimous agreement between industry experts and academic researchers that identifying and prioritizing inspection locations in secondary piping systems (for example, in raw water piping or diesel piping) would eliminate many excessive in-service inspections. The proposed structural health monitoring framework takes aim at answering this challenge by combining long-range guided wave technologies with other monitoring techniques, which can significantly increase the inspection length and pinpoint the locations that degraded the most. More widely, the report suggests research efforts aimed at developing, validating, and deploying online corrosion monitoring techniques for complex geometries, which are pervasive in NPPs.

  4. Vertical Subsurface Flow Mixing and Horizontal Anisotropy in Coarse Fluvial Aquifers: Structural Aspects

    Science.gov (United States)

    Huggenberger, P.; Huber, E.

    2014-12-01

    Detailed descriptions of the subsurface heterogeneities in coarse fluvial aquifer gravel often lack in concepts to distinguish between the essence and the noise of a permeability structure and the ability to extrapolate site specific hydraulic information at the tens to several hundred meters scale. At this scale the heterogeneity strongly influences the anisotropies of the flow field and the mixing processes in groundwater. However, in many hydrogeological models the complexity of natural systems is oversimplified. Understanding the link between the dynamics of the surface processes of braided-river systems and the resulting subsurface sedimentary structures is the key to characterizing the complexity of horizontal and vertical mixing processes in groundwater. From the different depositional elements of coarse braided-river systems, the largest permeability contrasts can be observed in the scour-fills. Other elements (e.g. different types of gravel sheets) show much smaller variabilities and could be considered as a kind of matrix. Field experiments on the river Tagliamento (Northeast Italy) based on morphological observation and ground-penetrating radar (GPR) surveys, as well as outcrop analyses of gravel pit exposures (Switzerland) allowed us to define the shape, sizes, spatial distribution and preservation potential of scour-fills. In vertical sections (e.g. 2D GPR data, vertical outcrop), the spatial density of remnant erosional bounding surfaces of scours is an indicator for the dynamics of the braided-river system (lateral mobility of the active floodplain, rate of sediment net deposition and spatial distribution of the confluence scours). In case of combined low aggradation rate and low lateral mobility the deposits may be dominated by a complex overprinting of scour-fills. The delineation of the erosional bounding surfaces, that are coherent over the survey area, is based on the identification of angular discontinuities of the reflectors. Fence diagrams

  5. Characterization and anti-settlement aspects of surface micro-structures from Cancer pagurus

    International Nuclear Information System (INIS)

    Sullivan, T; Regan, F; McGuinness, K; Connor, N E O’

    2014-01-01

    Tuning surface and material properties to inhibit or prevent settlement and attachment of microorganisms is of interest for applications such as antifouling technologies. Here, optimization of nano- and microscale structures on immersed surfaces can be utilized to improve cell removal while reducing adhesion strength and the likelihood of initial cellular attachment. Engineered surfaces capable of controlling cellular behaviour under natural conditions are challenging to design due to the diversity of attaching cell types in environments such as marine waters, where many variations in cell shape, size and adhesion strategy exist. Nevertheless, understanding interactions between a cell and a potential substrate for adhesion, including topographically driven settlement cues, offers a route to designing surfaces capable of controlling cell settlement. Biomimetic design of artificial surfaces, based upon microscale features from natural surfaces, can be utilized as model surfaces to understand cell–surface interactions. The microscale surface features of the carapace from the crustacean Cancer pagurus has been previously found to influence the rate of attachment of particular organisms when compared to smooth controls. However, the nature of microscale topographic features from C. pagurus have not been examined in sufficient detail to allow design of biomimetic surfaces. In this work, the spatial distribution, chemical composition, size and shape descriptors of microscale surface features from C. pagurus are characterized in detail for the first time. Additionally, the influence of topography from C. pagurus on the settlement of marine diatoms is examined under field conditions. (paper)

  6. Giant spermatozoa of Diasemopsis (Diopsidae, Diptera) - Structural, ultrastructural and functional aspects.

    Science.gov (United States)

    Kotrba, M; Heß, M; Dallai, R

    2016-01-01

    The spermatozoa of Diasemopsis comoroensis and Diasemopsis meigenii differ from the conventional brachyceran type in several respects. Not only are they very long but they are also extraordinarily wide, especially at the very end of the tail. The latter is effected by two cellular components: oversized mitochondrial derivatives and a prominent central band, which is a peculiar structure not known from any other spermatozoa. Based on its position with respect to the other organelles and its origin during early spermiogenesis, the central band is interpreted as a derivative of the centriolar adjunct material. Like the axoneme, the mitochondrial derivatives and the central band extend through the entire length of the spermatozoon tail. The spermatozoon tail is helical and can be coiled up into a tight cone-shaped spiral with a peculiar corkscrew shaped end portion. The potential adaptive significance of these features and their coevolution with the morphology of the female's multi-chambered ventral receptacle are discussed, as are sperm competition and cryptic female choice. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. STRUCTURAL AND STRATEGIC ASPECTS OF PROFESSIONALLY ORIENTED SPEECH OF A PSYCHOLOGIST MEDIATOR

    Directory of Open Access Journals (Sweden)

    Iryna Levchyk

    2016-12-01

    Full Text Available The article presents characteristic speech patterns of psychologist-mediator on the basis of five staged model of his professional speech behavior that involves the following five speech activities: introductory talks with the conflict parties; clarifying of the parties’ positions; finding the optimal solution to the problem; persuasion in the legality of a compromise; execution of the agreement between the parties. Each of these stages of the mediation process in terms of mental and speech activities of a specialist have been analyzed and subsequently the structure of mediator’s communication has been derived. The concept of a "strategy of verbal behavior" considering professional activity of a psychologist-mediator has been described in terms of its correlation with the type of negotiation behaviors of disputants. The basic types of opponents’ behavior in negotiations ‒ namely avoidance, concession, denial, aggression have been specified. The compliance of strategy of speech of mediator’s behavior to his chosen style of mediation has been discovered. The tactics and logic of mediator’s speech behavior according to the stages of mediation conversation have been determined. It has been found out that the mediator’s tactics implies application of specific professional speech skills to conduct a dialogue in accordance with the chosen strategy as well as emotional and verbal reaction of conflict sides in the process of communication.

  8. Vibronic Jahn-Teller coupling and structural-systematic aspects of superconductivity in ceramic materials

    International Nuclear Information System (INIS)

    Reinen, D.

    1993-09-01

    The following subjects were mainly investigated: 1. Development of a concept concerning the mechanism of superconductivity in ceramic oxides from the standpoint of solid state chemistry. An important criterion for generating superconductivity in ceramic oxides seems to be the overlap of a narrow, weakly antibonding and metal-centred band with a very broad band of predominant oxygen character in the Fermi region. Spectroscopic investigations are in favour of such a concept and additionally indicate a vibronic coupling mechanism of the Jahn-Teller- or pseudo-Jahn-Teller type. 2. Synthesis of potentially superconducting ceramic oxides. A series of oxidic compounds with transition metal ions (Ni 2+ /Ni 3+ /Ni 4+ , Mn 3+ /Mn 4+ , Cu 2+ /Cu 3+ etc.) and with cations, possessing a lone electron pair (Sb 3+ , Bi 3+ , Pb 2+ , Tl + ) was prepared (K 2 NiF 4 -structure). The investigation of these ceramic materials led to interesting insight into the nature of the M-O-bond and the cooperative interactions between the metal ion centres; new superconductors could not be synthesized, however. (orig.) [de

  9. [Genetic aspects of species structure of the compost worm Eisenia foetida (Sav.) (Oligochaeta, Lumbricidae)].

    Science.gov (United States)

    Bolotetskiĭ, N M; Kodolova, O P

    2002-01-01

    Distribution of frequencies alleles of polymorphous loci of peroxidase (Pox), leucineaminopeptidase (Lap), phosphoglucomutase (Pgm) and octanoldehydrogenase (Odh) were studied by electrophoresis in polyacrylamide gel in 22 local samples of Esenia foetida in Russia (European part), Ukraine, Kazakhstan and Kirghizia. The samples form two spatial groups--"northern" and "southern", distinguished by set of alleles in every studied locus. The "northern" groups is formed by local populations of European Russia from Murmansk region on the north to Smolensk region on the south, and also by cultivated population of selection line "red California hybrid". The "southern" group is formed by local populations on the territory of Russia from middle Volga to the North Caucasus, Ukraine, Kazakhstan, Kirghizia, cultivated populations from Kirghizia and Portugal. High degree of genetic difference between samples and independence of alleles frequencies distribution from geographical location and habitat allows to consider almost all studied groups as separate populations. Statistical processing of Nei genetic distances (Nei, 1972) revealed reliable differences between averages of within- and intergroup distances. Besides, discrete differences between intervals of significance of genetic distances were revealed. The results indicate that on the studied territory E. foetida has hierarchical two level structure. The first level is formed by local populations differed by frequency of the same alleles. The second level is formed by local populations, united into spatial groups, that are qualitatively distinguished by the set of alleles in the same loci.

  10. Research and evaluation of innovative integrated industrial structure potential: theoretical and practical aspects

    Directory of Open Access Journals (Sweden)

    Zdolnikova S.V.

    2017-01-01

    Full Text Available Modern market conditions, as well as the reorientation of the Russian economy from raw materials to the innovative model of development, based, in particular, on strengthening the position of domestic industry being able to compete against the international producers, are the incentives to seek ways to increase efficiency and create additional competitive advantages that at present are innovative products and services. One of the innovative economic entity development factors is the establishment and effective use of its innovative potential. The innovative potential evaluation plays an important role in the development of innovation policy and innovation strategy of market subject activity. This article investigates the innovative potential of the integrated industrial structures (IIS that presently are one of the most promising forms of economic entities integration. The authors propose an approach to the definition and assessment of innovative IIS potential, as well as the comprehensive and systemic innovative potential estimation procedure. The developed theoretical and methodological provisions were applied to evaluate the innovative potential of the JSC Svetlana, one of the leading Russian electronic instrument engineering holdings.

  11. Biomaterials from blends of fluoropolymers and corn starch-implant and structural aspects.

    Science.gov (United States)

    Pereira, João D A S; Camargo, Regina C T; Filho, José C S C; Alves, Neri; Rodriguez-Perez, Miguel A; Constantino, Carlos J L

    2014-03-01

    The development of polymeric blends to be used as matrices for bone regeneration is a hot topic nowadays. In this article we report on the blends composed by corn starch and poly(vinylidene fluoride), PVDF, or poly(vinylidene fluoride-trifluoroethylene), P(VDF-TrFE), to obtain biocompatible materials. Blends were produced by compressing/annealing and chemically/structurally characterized by micro-Raman scattering and Fourier transform infrared (FTIR) absorption spectroscopies, dynamic mechanical analysis (DMA) and scanning electron microscopy (SEM), besides in vivo study to evaluate the tissue response. Vibrational spectroscopy reveals no chemical interaction between the polymers and starch, absence of material degradation due to compressing/annealing process or organism implantation, and maintenance of α and ferroelectric crystalline phases of PVDF and P(VDF-TrFE), respectively. As a consequence of absence of interaction between polymers and starch, it was possible to identify by SEM each material, with starch acting as filler. Elastic modulus (E') obtained from DMA measurement, independent of the material proportion used in blends, reaches values close to those of cancellous bone. Finally, the in vivo study in animals shows that the blends, regardless of the composition, were tolerated by cancellous bone. Copyright © 2013 Elsevier B.V. All rights reserved.

  12. Novel aspects of blood coagulation factor XIII. I. Structure, distribution, activation, and function

    Energy Technology Data Exchange (ETDEWEB)

    Muszbek, L.; Adany, R. [Univ. Medical School of Debrecen (Hungary); Mikkola, H. [Univ. of Helsinki (Finland)

    1996-10-01

    Blood coagulation factor XIII (FXIII) is a protransglutaminase that becomes activated by the concerted action of thrombin and Ca{sup 2+} in the final stage of the clotting cascade. In addition to plasma, FXIII also occurs in platelets, monocytes, and monocyte-derived macrophages. While the plasma factor is a heterotetramer consisting of paired A and B subunits (A{sub 2}B{sub 2}), its cellular counterpart lacks the B subunits and is a homodimer of potentially active A subunits (A{sub 2}). The gene coding for the A and B subunits has been localized to chromosomes 6p24-25 and 1q31-32.1, respectively. The genomic as well as the primary protein structure of both subunits has been established. Plasma FXIII circulates in association with its substrate precursor, fibrinogen. Fibrin(ogen) has an important regulatory role in the activation of plasma FXIII, for instance the proteolytic removal of activation peptide by thrombin, the dissociation of subunits A and B, and the exposure of the originally buried active site on the free A subunits. The end result of this process is the formation of an active transglutaminase, which crosslinks peptide chains through {epsilon}({gamma}-glutamyl)lysyl isopeptide bonds. The protein substrates of activated FXIII include components of the clotting-fibrinolytic system, adhesive and contractile proteins. The main physiological function of plasma FXIII is to cross-link fibrin and protect it from the fibrinolytic enzyme plasmin. The latter effect is achieved mainly by covalently linking {alpha}{sub 2} antiplasmin, the most potent physiological inhibitor of plasmin, to fibrin. Plasma FXIII seems to be involved in wound healing and tissue repair, and it is essential to maintaining pregnancy. Cellular FXIII, if exposed to the surface of the cells, might support or perhaps take over the hemostatic functions of plasma FXIII; however, its intracellular role has remained mostly unexplored. 328 refs., 4 figs.

  13. Biomaterials from blends of fluoropolymers and corn starch—implant and structural aspects

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, João D.A.S. [Faculdade de Ciências e Tecnologia, UNESP Univ Estadual Paulista, 19060-900 Presidente Prudente, SP, Brazil. (Brazil); Condensed Matter Physics Department, CellMat Laboratory, Faculty of Science, University of Valladolid, Valladolid Spain (Spain); Camargo, Regina C.T.; Filho, José C.S.C.; Alves, Neri [Faculdade de Ciências e Tecnologia, UNESP Univ Estadual Paulista, 19060-900 Presidente Prudente, SP, Brazil. (Brazil); Rodriguez-Perez, Miguel A. [Condensed Matter Physics Department, CellMat Laboratory, Faculty of Science, University of Valladolid, Valladolid Spain (Spain); Constantino, Carlos J.L., E-mail: case@fct.unesp.br [Faculdade de Ciências e Tecnologia, UNESP Univ Estadual Paulista, 19060-900 Presidente Prudente, SP, Brazil. (Brazil)

    2014-03-01

    The development of polymeric blends to be used as matrices for bone regeneration is a hot topic nowadays. In this article we report on the blends composed by corn starch and poly(vinylidene fluoride), PVDF, or poly(vinylidene fluoride-trifluoroethylene), P(VDF-TrFE), to obtain biocompatible materials. Blends were produced by compressing/annealing and chemically/structurally characterized by micro-Raman scattering and Fourier transform infrared (FTIR) absorption spectroscopies, dynamic mechanical analysis (DMA) and scanning electron microscopy (SEM), besides in vivo study to evaluate the tissue response. Vibrational spectroscopy reveals no chemical interaction between the polymers and starch, absence of material degradation due to compressing/annealing process or organism implantation, and maintenance of α and ferroelectric crystalline phases of PVDF and P(VDF-TrFE), respectively. As a consequence of absence of interaction between polymers and starch, it was possible to identify by SEM each material, with starch acting as filler. Elastic modulus (E′) obtained from DMA measurement, independent of the material proportion used in blends, reaches values close to those of cancellous bone. Finally, the in vivo study in animals shows that the blends, regardless of the composition, were tolerated by cancellous bone. - Highlights: • Spectroscopy shows no chemical interaction between the polymers and starch. • It was possible to identify by SEM each material, with starch acting as filler. • The modulus of elasticity (E′) reaches values close to those of cancellous bone. • In vivo study in animals shows that the blends were tolerated by cancellous bone. • Cell aggregates present at outside region of implanted samples suggest bone healing.

  14. Structure-function aspects of PstS in multi-drug-resistant Pseudomonas aeruginosa.

    Directory of Open Access Journals (Sweden)

    Olga Zaborina

    2008-02-01

    Full Text Available The increasing prevalence of multi-drug-resistant (MDR strains of Pseudomonas aeruginosa among critically ill humans is of significant concern. In the current study, we show that MDR clinical isolates of P. aeruginosa representing three distinct genotypes that display high virulence against intestinal epithelial cells, form novel appendage-like structures on their cell surfaces. These appendages contain PstS, an extracellular phosphate binding protein. Using anti-PstS antibodies, we determined that the PstS-rich appendages in MDR strains are involved in adherence to and disruption of the integrity of cultured intestinal epithelial cell monolayers. The outer surface-expressed PstS protein was also identified to be present in P. aeruginosa MPAO1, although to a lesser degree, and its role in conferring an adhesive and barrier disruptive phenotype against intestinal epithelial cells was confirmed using an isogenic DeltaPstS mutant. Formation of the PstS rich appendages was induced during phosphate limitation and completely suppressed in phosphate-rich media. Injection of MDR strains directly into the intestinal tract of surgically injured mice, a known model of phosphate limitation, caused high mortality rates (60%-100%. Repletion of intestinal phosphate in this model completely prevented mortality. Finally, significantly less outer surface PstS was observed in the MPAO1 mutant DeltaHxcR thus establishing a role for the alternative type II secretion system Hxc in outer surface PstS expression. Gene expression analysis performed by RT-PCR confirmed this finding and further demonstrated abundant expression of pstS analogous to pa5369, pstS analogous to pa0688/pa14-55410, and hxcX in MDR strains. Taken together, these studies provide evidence that outer surface PstS expression confers a highly virulent phenotype of MDR isolates against the intestinal epithelium that alters their adhesive and barrier disrupting properties against the intestinal

  15. Structural and functional aspects of trypsin–gold nanoparticle interactions: An experimental investigation

    Energy Technology Data Exchange (ETDEWEB)

    Nidhin, Marimuthu [Department of Chemistry, Amity School of Applied Sciences, Center for Nanoscience and Technology, Amity University Haryana Amity Education Valley, Gurgaon, Haryana 122413 (India); Ghosh, Debasree [Department of Nanotechnology, Amity School of Applied Sciences, Center for Nanoscience and Technology, Amity University Haryana Amity Education Valley, Gurgaon, Haryana 122413 (India); Yadav, Himanshu; Yadav, Nitu [Department of Chemistry, Amity School of Applied Sciences, Center for Nanoscience and Technology, Amity University Haryana Amity Education Valley, Gurgaon, Haryana 122413 (India); Majumder, Sudip, E-mail: sudip22m@gmail.com [Department of Chemistry, Amity School of Applied Sciences, Center for Nanoscience and Technology, Amity University Haryana Amity Education Valley, Gurgaon, Haryana 122413 (India)

    2015-12-15

    Highlights: • Trypsin undergoes activation on incubation with gold nanoparticles. • Enhanced activity depends on the stoichiometry of the mixture. • Higher concentration of nanoparticles damage stability and conformation of trypsin. • Gold nanoparticles undergo morphological change on incubation with trypsin. - Abstract: Trypsin (Trp) is arguably the most important member of the serine proteases. Constructs made up of gold nanoparticles (GNP) with trypsin have been known to exhibit increased efficiency and stability in various experiments. Here we report simple Trp–GNP constructs mixed in different trypsin-to-GNP ratios which exhibit higher efficiencies in biochemical assay, varying resistance to autolysis and higher ability in cell trypsinization. Trp–GNP constructs in different trypsin-to-GNP ratios exhibit prolonged and sustained activity compared to native trypsin in N-α-p-benzoyl-p-nitroanilide (BAPNA) assay as monitored by UV-Visible spectroscopy. The activity was monitored as a function of decreasing rate of linear release of p-nitro aniline (resulting from the cleavage of BAPNA by trypsin) with time during the assay, whose absorbance was measured at 410 nm (λ{sub max} p-nitro aniline). We have done extensive studies to understand structural basis of this trypsin GNP interaction by using atomic force microscopy (AFM), transmission electron microscopy (TEM) and circular dichroism (CD) techniques. Our findings suggest that on interaction, the gold nanoparticles probably form an adherent layer on trypsin that effectively changes the morphology and dimensions of the nanoconstructs. However, trypsin-to-GNP ratio is extremely important, as higher concentration of GNP might damage the conformation of protein. Stability studies related to denaturation show that 1:1 Trp–GNP constructs exhibit maximum stability and high efficiency in all assays performed.

  16. Biomaterials from blends of fluoropolymers and corn starch—implant and structural aspects

    International Nuclear Information System (INIS)

    Pereira, João D.A.S.; Camargo, Regina C.T.; Filho, José C.S.C.; Alves, Neri; Rodriguez-Perez, Miguel A.; Constantino, Carlos J.L.

    2014-01-01

    The development of polymeric blends to be used as matrices for bone regeneration is a hot topic nowadays. In this article we report on the blends composed by corn starch and poly(vinylidene fluoride), PVDF, or poly(vinylidene fluoride-trifluoroethylene), P(VDF-TrFE), to obtain biocompatible materials. Blends were produced by compressing/annealing and chemically/structurally characterized by micro-Raman scattering and Fourier transform infrared (FTIR) absorption spectroscopies, dynamic mechanical analysis (DMA) and scanning electron microscopy (SEM), besides in vivo study to evaluate the tissue response. Vibrational spectroscopy reveals no chemical interaction between the polymers and starch, absence of material degradation due to compressing/annealing process or organism implantation, and maintenance of α and ferroelectric crystalline phases of PVDF and P(VDF-TrFE), respectively. As a consequence of absence of interaction between polymers and starch, it was possible to identify by SEM each material, with starch acting as filler. Elastic modulus (E′) obtained from DMA measurement, independent of the material proportion used in blends, reaches values close to those of cancellous bone. Finally, the in vivo study in animals shows that the blends, regardless of the composition, were tolerated by cancellous bone. - Highlights: • Spectroscopy shows no chemical interaction between the polymers and starch. • It was possible to identify by SEM each material, with starch acting as filler. • The modulus of elasticity (E′) reaches values close to those of cancellous bone. • In vivo study in animals shows that the blends were tolerated by cancellous bone. • Cell aggregates present at outside region of implanted samples suggest bone healing

  17. Structural and functional aspects of the myosin essential light chain in cardiac muscle contraction

    Energy Technology Data Exchange (ETDEWEB)

    Muthu, Priya; Wang, Li; Yuan, Chen-Ching; Kazmierczak, Katarzyna; Huang, Wenrui; Hernandez, Olga M.; Kawai, Masataka; Irving, Thomas C.; Szczesna-Cordary, Danuta (IIT); (Iowa); (Miami-MED)

    2012-04-02

    The myosin essential light chain (ELC) is a structural component of the actomyosin cross-bridge, but its function is poorly understood, especially the role of the cardiac specific N-terminal extension in modulating actomyosin interaction. Here, we generated transgenic (Tg) mice expressing the A57G (alanine to glycine) mutation in the cardiac ELC known to cause familial hypertrophic cardiomyopathy (FHC). The function of the ELC N-terminal extension was investigated with the Tg-{Delta}43 mouse model, whose myocardium expresses a truncated ELC. Low-angle X-ray diffraction studies on papillary muscle fibers in rigor revealed a decreased interfilament spacing ({approx} 1.5 nm) and no alterations in cross-bridge mass distribution in Tg-A57G mice compared to Tg-WT, expressing the full-length nonmutated ELC. The truncation mutation showed a 1.3-fold increase in I{sub 1,1}/I{sub 1,0}, indicating a shift of cross-bridge mass from the thick filament backbone toward the thin filaments. Mechanical studies demonstrated increased stiffness in Tg-A57G muscle fibers compared to Tg-WT or Tg-{Delta}43. The equilibrium constant for the cross-bridge force generation step was smallest in Tg-{Delta}43. These results support an important role for the N-terminal ELC extension in prepositioning the cross-bridge for optimal force production. Subtle changes in the ELC sequence were sufficient to alter cross-bridge properties and lead to pathological phenotypes.

  18. Impulsivity and Concussion in Juvenile Rats: Examining Molecular and Structural Aspects of the Frontostriatal Pathway.

    Directory of Open Access Journals (Sweden)

    Harleen Hehar

    Full Text Available Impulsivity and poor executive control have been implicated in the pathogenesis of many developmental and neuropsychiatric disorders. Similarly, concussions/mild traumatic brain injuries (mTBI have been associated with increased risk for neuropsychiatric disorders and the development of impulsivity and inattention. Researchers and epidemiologists have therefore considered whether or not concussions induce symptoms of attention-deficit/hyperactivity disorder (ADHD, or merely unmask impulsive tendencies that were already present. The purpose of this study was to determine if a single concussion in adolescence could induce ADHD-like impulsivity and impaired response inhibition, and subsequently determine if inherent impulsivity prior to a pediatric mTBI would exacerbate post-concussion symptomology with a specific emphasis on impulsive and inattentive behaviours. As these behaviours are believed to be associated with the frontostriatal circuit involving the nucleus accumbens (NAc and the prefrontal cortex (PFC, the expression patterns of 8 genes (Comt, Drd2, Drd3, Drd4, Maoa, Sert, Tph1, and Tph2 from these two regions were examined. In addition, Golgi-Cox staining of medium spiny neurons in the NAc provided a neuroanatomical examination of mTBI-induced structural changes. The study found that a single early brain injury could induce impulsivity and impairments in response inhibition that were more pronounced in males. Interestingly, when animals with inherent impulsivity experienced mTBI, injury-related deficits were exacerbated in female animals. The single concussion increased dendritic branching, but reduced synaptic density in the NAc, and these changes were likely associated with the increase in impulsivity. Finally, mTBI-induced impulsivity was associated with modifications to gene expression that differed dramatically from the gene expression pattern associated with inherent impulsivity, despite very similar behavioural phenotypes. Our

  19. Aspectos estruturais da membrana eritrocitária Structural aspects of the erythrocyte membrane

    Directory of Open Access Journals (Sweden)

    Priscila Murador

    2007-06-01

    ócito e é ainda responsável pela estabilidade sob mecanismos de estresse. Essa revisão da membrana eritrocitária é importante para um melhor entendimento das reações transfusionais, onde a formação de anticorpos contra antígenos de alta freqüência dificulta a transfusão compatível. O estudo da diversidade antigênica, a caracterização bioquímica de diferentes proteínas trará uma contribuição para o estabelecimento da saúde, assim como para o diagnóstico, desenvolvimento de tecnologias, como a produção de anticorpos monoclonais e conduta terapêutica para muitas enfermidades.This article describes the structures and functions of the erythrocyte membrane and its importance in transfusional medicine. The erythrocyte membrane is one of the best known membranes in terms of structure, function and genetic disorders. As any other plasma membrane, it mediates transport functions. It also provides the erythrocytes with their resilience and deformability. According to the International Society of Blood Transfusion (ISBT, more than 500 antigens are expressed in the erythrocyte membrane, and around 270 are involved in transfusion reaction cases and hemolytic diseases of the fetus and newborn. In the ISBT classification, the high frequency series is represented by antigens in more than 99% of population (high prevalence antigen. In transfusion, the absence of these antigens determines severe problems as for example, one woman without the P antigen suffered 6 repetitive miscarriages due to placental insufficiency, which was caused by an antibody formed against the absent P antigen. Some important erythrocyte membrane proteins are described here including Band 3, Glycophorins and spectrin. The most abundant integral membrane protein is Band 3 and its main function is to mediate exchange of chloride and bicarbonate anions across the plasma membrane. The second most abundant integral membrane protein in the human erythrocyte is sialoglycoprotein glycophorin A (GPA

  20. Associations between the structural and functional aspects of social relations and poor mental health: a cross-sectional register study.

    Science.gov (United States)

    Hansen, Lise Røntved; Pedersen, Stinna Bibi; Overgaard, Charlotte; Torp-Pedersen, Christian; Ullits, Line Rosenkilde

    2017-11-03

    Social relations influence mental health through different pathways. To capture the complexity of social relations, it is beneficial to consider both the structural (e.g., reachability of social network and social integration) and functional (e.g., instrumental and emotional support) aspects of the concept. Both aspects are rarely investigated simultaneously. This study aimed to examine the association between the structural and functional aspects of social relations and poor mental health. The study was designed as a cross-sectional register study. We used data on mental health and social relations from 15,839 individuals aged 16-92 years with a mean age of 49.0 years (SD 17.9) who responded to The North Denmark Region Health Survey 2013 among residents in Northern Jutland, Denmark. The 12-Item Short-Form Health Survey measured mental health; a cut-off point of 44.5 was used to dichotomize participants into poor and good mental health. The categorization of social relations was inspired by Berkman et al.'s conceptual model of social relations and health. The analyses were performed with survey logistic regression. We found that 21.6% (n = 3422) of participants reported poor mental health, and 59% (n = 2020) of these were women. Being in contact with family and friends less than once a month statistically significantly increased the risk for poor mental health (Family OR = 1.78, 95% CI = 1.51-2.10 and Friends OR = 2.65, 95% CI = 2.30-3.06). The individuals who were not in contact with their network as often as they liked had a significantly higher risk for poor mental health (OR = 2.40, 95% CI = 2.20-2.62). Lack of instrumental support was associated with a higher risk for poor mental health (OR = 2.81, 95% CI = 2.26-3.48). We found an interaction between age and emotional support; the youngest population had the highest risk for poor mental health when they did not have access to emotional support (Young OR = 5.26, 95% CI = 3

  1. FRAMEWORK FOR STRUCTURAL ONLINE HEALTH MONITORING OF AGING AND DEGRADATION OF SECONDARY PIPING SYSTEMS DUE TO SOME ASPECTS OF EROSION

    Energy Technology Data Exchange (ETDEWEB)

    Gribok, Andrei V.; Agarwal, Vivek

    2017-06-01

    This paper describes the current state of research related to critical aspects of erosion and selected aspects of degradation of secondary components in nuclear power plants (NPPs). The paper also proposes a framework for online health monitoring of aging and degradation of secondary components. The framework consists of an integrated multi-sensor modality system, which can be used to monitor different piping configurations under different degradation conditions. The report analyses the currently known degradation mechanisms and available predictive models. Based on this analysis, the structural health monitoring framework is proposed. The Light Water Reactor Sustainability Program began to evaluate technologies that could be used to perform online monitoring of piping and other secondary system structural components in commercial NPPs. These online monitoring systems have the potential to identify when a more detailed inspection is needed using real time measurements, rather than at a pre-determined inspection interval. This transition to condition-based, risk-informed automated maintenance will contribute to a significant reduction of operations and maintenance costs that account for the majority of nuclear power generation costs. Furthermore, of the operations and maintenance costs in U.S. plants, approximately 80% are labor costs. To address the issue of rising operating costs and economic viability, in 2017, companies that operate the national nuclear energy fleet started the Delivering the Nuclear Promise Initiative, which is a 3 year program aimed at maintaining operational focus, increasing value, and improving efficiency. There is unanimous agreement between industry experts and academic researchers that identifying and prioritizing inspection locations in secondary piping systems (for example, in raw water piping or diesel piping) would eliminate many excessive in-service inspections. The proposed structural health monitoring framework takes aim at

  2. Two aspects of one loop structure: Unitarity delay in the Standard Model and modular invariance in string theory

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, C.

    1989-08-01

    We study two aspects of one loop structures in quantum field theories which describe two different areas of particle physics: the one loop unitarity behavior of the Standard Model of electroweak interactions and modular invariance of string model theory. Loop expansion has its importance in that it contains quantum fluctuations due to all physical states in the theory. Therefore, by studying the various models to one loop, we can understand how the contents of the theory can contribute to physically measurable quantities and how the consistency at quantum level restricts the physical states of the theory, as well. In the first half of the thesis, we study one loop corrections to the process {ital e}{sup +}{ital e}{sup {minus}} {yields} {ital W}{sup +}{ital W}{sup {minus}}. In this process, there is a delicate unitarity-saving cancellation between s-channel and t-channel tree level Feynman diagrams. If the one loop contribution due to heavy particles corrects the channels asymmetrically, the cancellation, hence unitarity, will be delayed up to the mass scale of these heavy particles. We refer to this phenomena as the unitarity delay effect. Due to this effect, cross section below these mass scales can have significant radiative corrections which may provide an appropriate window through which we can see the high energy structure of the Standard Model from relatively low energy experiments. In the second half, we will show how quantum consistency can restrict the physical states in string theory. 53 refs., 13 figs.

  3. Two aspects of one loop structure: Unitarity delay in the Standard Model and modular invariance in string theory

    International Nuclear Information System (INIS)

    Ahn, C.

    1989-08-01

    We study two aspects of one loop structures in quantum field theories which describe two different areas of particle physics: the one loop unitarity behavior of the Standard Model of electroweak interactions and modular invariance of string model theory. Loop expansion has its importance in that it contains quantum fluctuations due to all physical states in the theory. Therefore, by studying the various models to one loop, we can understand how the contents of the theory can contribute to physically measurable quantities and how the consistency at quantum level restricts the physical states of the theory, as well. In the first half of the thesis, we study one loop corrections to the process e + e - → W + W - . In this process, there is a delicate unitarity-saving cancellation between s-channel and t-channel tree level Feynman diagrams. If the one loop contribution due to heavy particles corrects the channels asymmetrically, the cancellation, hence unitarity, will be delayed up to the mass scale of these heavy particles. We refer to this phenomena as the unitarity delay effect. Due to this effect, cross section below these mass scales can have significant radiative corrections which may provide an appropriate window through which we can see the high energy structure of the Standard Model from relatively low energy experiments. In the second half, we will show how quantum consistency can restrict the physical states in string theory. 53 refs., 13 figs

  4. Studies of extractant molecules in solution and at liquid-liquid interfaces: structural and mechanistic aspects of synergy effects

    International Nuclear Information System (INIS)

    Baaden, Marc

    2000-01-01

    Molecular dynamics simulations reported herein provide new important insights into cation recognition and complexation in solution as well as liquid-liquid extraction, with a particular focus on the microscopic events taking place at the interface between two immiscible liquids. Preliminary studies concerned the representation of the trivalent rare earth cations La 3+ , Eu 3+ and Yb 3+ in force field simulations, probing structural and energetic features on an experimentally characterized model system based on substituted pyridine dicarboxamide ligands. Complexation of such cations by a novel calixarene derivative was investigated showing unexpected features, such as the position of the cation in the complex. Independent experimental studies published subsequently support these findings. Another part of the work is related to industrial liquid-liquid extraction systems using tri-n-butyl phosphate (TBP) as co-solvent, extractant, surfactant and synergist. We investigate 1) concentration effects simulating up to 60 TBP at a water/chloroform interface, 2) acidity using a neutral and ionic model of HNO 3 and 3) synergistic aspects of mixed TBP/calixarene extraction systems. These simulations provide the first microscopic insights into such issues. We finally addressed the topic of solute transfer across the water/chloroform interface. The potential of mean force for such a process has been calculated by both standard methods and novel approaches [fr

  5. Aspects of the structure of film expression and anthropological paradigm of films reception in Croatian cinema and TV distribution.

    Science.gov (United States)

    Svilicić, Niksa

    2012-09-01

    This research paper deals with one part of a comprehensive study called "Causality of narratological-semiotic aspects of the structure of film expression and paradigms of reception of Croatian feature film". It is conceived as a response to the hypothesis that the expression of narrative-semiotic terms correlate with the reception of the Croatian feature film audience and all them leads into a broader holistic i.e. anthropological context.The basic idea of scientific research is to analyze the complete feature productions since Croatian independence 1991 to date, presented at the National Film Festival (film festival in Pula), identify, define and isolate positive social narrative-semiotic stereotypes, which can then serve as a paradigm of better ratings and increase of the currently very low rating of domestic films in Croatian cinemas, as well as TV distribution. In other words, the paper will be analyzed and processed by a range of different effects based on narrative-semiotic, set design and mise-en-scène motives, used in the Croatian feature films since independence to date, that we assume to positively influence the mood of the viewer, and thus increase the rating of the film.

  6. Structural, functional, and evolutionary aspects of galectins in aquatic mollusks: From a sweet tooth to the Trojan horse.

    Science.gov (United States)

    Vasta, G R; Feng, C; Bianchet, M A; Bachvaroff, T R; Tasumi, S

    2015-09-01

    Galectins constitute a conserved and widely distributed lectin family characterized by their binding affinity for β-galactosides and a unique binding site sequence motif in the carbohydrate recognition domain (CRD). In spite of their structural conservation, galectins display a remarkable functional diversity, by participating in developmental processes, cell adhesion and motility, regulation of immune homeostasis, and recognition of glycans on the surface of viruses, bacteria and protozoan parasites. In contrast with mammals, and other vertebrate and invertebrate taxa, the identification and characterization of bona fide galectins in aquatic mollusks has been relatively recent. Most of the studies have focused on the identification and domain organization of galectin-like transcripts or proteins in diverse tissues and cell types, including hemocytes, and their expression upon environmental or infectious challenge. Lectins from the eastern oyster Crassostrea virginica, however, have been characterized in their molecular, structural and functional aspects and some notable features have become apparent in the galectin repertoire of aquatic mollusks. These including less diversified galectin repertoires and different domain organizations relative to those observed in vertebrates, carbohydrate specificity for blood group oligosaccharides, and up regulation of galectin expression by infectious challenge, a feature that supports their proposed role(s) in innate immune responses. Although galectins from some aquatic mollusks have been shown to recognize microbial pathogens and parasites and promote their phagocytosis, they can also selectively bind to phytoplankton components, suggesting that they also participate in uptake and intracellular digestion of microalgae. In addition, the experimental evidence suggests that the protozoan parasite Perkinsus marinus has co-evolved with the oyster host to be selectively recognized by the oyster hemocyte galectins over algal food

  7. Instability and associated roll structure of Marangoni convection in high Prandtl number liquid bridge with large aspect ratio

    Science.gov (United States)

    Yano, T.; Nishino, K.; Kawamura, H.; Ueno, I.; Matsumoto, S.

    2015-02-01

    This paper reports the experimental results on the instability and associated roll structures (RSs) of Marangoni convection in liquid bridges formed under the microgravity environment on the International Space Station. The geometry of interest is high aspect ratio (AR = height/diameter ≥ 1.0) liquid bridges of high Prandtl number fluids (Pr = 67 and 207) suspended between coaxial disks heated differentially. The unsteady flow field and associated RSs were revealed with the three-dimensional particle tracking velocimetry. It is found that the flow field after the onset of instability exhibits oscillations with azimuthal mode number m = 1 and associated RSs traveling in the axial direction. The RSs travel in the same direction as the surface flow (co-flow direction) for 1.00 ≤ AR ≤ 1.25 while they travel in the opposite direction (counter-flow direction) for AR ≥ 1.50, thus showing the change of traveling directions with AR. This traveling direction for AR ≥ 1.50 is reversed to the co-flow direction when the temperature difference between the disks is increased to the condition far beyond the critical one. This change of traveling directions is accompanied by the increase of the oscillation frequency. The characteristics of the RSs for AR ≥ 1.50, such as the azimuthal mode of oscillation, the dimensionless oscillation frequency, and the traveling direction, are in reasonable agreement with those of the previous sounding rocket experiment for AR = 2.50 and those of the linear stability analysis of an infinite liquid bridge.

  8. Narrow conductive structures with high aspect ratios through single-pass inkjet printing and evaporation-induced dewetting

    NARCIS (Netherlands)

    Abbel, R.; Teunissen, P.; Michels, J.; Groen, W.A.

    2015-01-01

    Inkjet printed silver lines contract to widths below 20-μm during drying on an organic planarization coating. Aspect ratios previously unprecedented with single pass inkjet printing on isotropic homogeneous substrates are obtained. This effect is caused by the subsequent evaporation of solvents from

  9. Molecular aspects of toxicology

    National Research Council Canada - National Science Library

    Hathway, D. E

    1984-01-01

    The subject matter of this book is organized into chapters that deal wwith separate subjects and, whilst this treatment reveals the structure of molecular aspects of toxicology, it inevitably incurs...

  10. A density functional reactivity theory (DFRT) based approach to understand the effect of symmetry of fullerenes on the kinetic, thermodynamic and structural aspects of carbon NanoBuds

    International Nuclear Information System (INIS)

    Sarmah, Amrit; Roy, Ram Kinkar

    2016-01-01

    Highlights: • Kinetic and thermodynamic aspects of the interaction between fullerene (C 32 ) and SWCNT using CDASE scheme. • Role of symmetry of fullerenes as well as the site of covalent attachment to the SWCNT in the structural stability of the NanoBud structure. • Increase in the fullerene symmetry improves the relative stability of hybrid NanoBud structure. - Abstract: In the present study, we have rationalized the effect of variation in the symmetry of relatively smaller fullerene (C 32 ) on the mode of its interaction with semi-conducting Single-Walled Carbon Nanotubes (SWCNTs) in the process of formation of stable hybrid carbon NanoBuds. Thermodynamic and kinetic parameters, along with the charge transfer values associated with the interaction between fullerene and SWCNTs, have been evaluated using an un-conventional and computationally cost–effective method based on density functional reactivity theory (DFRT). In addition to this, conventional DFT based studies are also performed to substantiate the growth of NanoBud structures formed by the interaction between fullerene and SWCNTs. The findings of the present study suggest that the kinetic, thermodynamic and structural aspects of hybrid carbon NanoBuds are significantly influenced by both the symmetry of C 32 fullerene and its site of covalent attachment to the SWCNT.

  11. Sacrificial structures for deep reactive ion etching of high-aspect ratio kinoform silicon x-ray lenses

    DEFF Research Database (Denmark)

    Stöhr, Frederik; Michael-Lindhard, Jonas; Hübner, Jörg

    2015-01-01

    investigated how sacrificial structures in the form of guarding walls and pillars may be utilized to facilitate accurate control of the etch profile. Unlike other sacrificial structuring approaches, no silicon-on-insulator substrates or multiple lithography steps are required. In addition, the safe removal...... of the sacrificial structures was accomplished by thermal oxidation and subsequent selective wet etching. The effects of the dimensions and relative placement of sacrificial walls and pillars on the etching result were determined through systematic experiments. The authors applied this process for exact sidewall...

  12. Structural aspects of the new quasi-2-D heavy fermion materials CeIrIns and CeRhIns

    International Nuclear Information System (INIS)

    Moshopoulou, E.G.; Moshopoulou, E.G.; Fisk, Z.; Sarrao, J.L.; Thompson, J.D.; Fisk, Z.

    2002-01-01

    The title compounds are new heavy fermion materials. They adopt a quasi two-dimensional crystal structure and exhibit unusual (for a heavy fermion system) low temperature properties. Although the study of their physical and structural behaviour at low temperatures and/or high pressures is still in progress, we present here some results concerning their average crystal structure, and we discuss very briefly their similarities and differences with the compounds CeIn3 and UTGa 5 (T: Co, Ni, Ir, Pd, Cu, Ru). (authors)

  13. Aspects of mast building and the fine structure of “amphipod silk” glands in Dyopedos bispinis (Amphipoda, Dulichiidae)

    NARCIS (Netherlands)

    Neretin, N.Y.; Zhadan, A.E.; Tzetlin, A.B.

    2017-01-01

    In the present study, we investigated the biology of Dyopedos bispinis, a mast-building amphipod that is abundant near the N. Pertsov White Sea Biological Station. To examine the peculiarities of mast building in Dyopedos bispinis, we studied the social structure of individuals inhabiting the masts

  14. Typography for Graphic Communication [and] Typographic Access Structures for Educational Texts [and] Graphic Aspects of Complex Texts: Typography as Macropunctuation.

    Science.gov (United States)

    Waller, Robert

    The three papers included in this report address typography for graphic communication, typographic access structures for educational texts, and typography as macropunctuation. The first paper considers the consequences of an aesthetic bias in the literature of typography, and identifies two misleading assumptions about textbooks; i.e., that print…

  15. Advances in Alkenone Paleotemperature Proxies: Analytical Methods, Novel Structures and Haptophyte Species, Biosynthesis, New indices and Ecological Aspects

    Science.gov (United States)

    Huang, Y.; Longo, W. M.; Zheng, Y.; Richter, N.; Dillon, J. T.; Theroux, S.; D'Andrea, W. J.; Toney, J. L.; Wang, L.; Amaral-Zettler, L. A.

    2017-12-01

    Alkenones are mature, well-established paleo-sea surface temperature proxies that have been widely applied for more than three decades. However, recent advances across a broad range of alkenone-related topics at Brown University are inviting new paleoclimate and paleo-environmental applications for these classic biomarkers. In this presentation, I will summarize our progress in the following areas: (1) Discovery of a freshwater alkenone-producing haptophyte species and structural elucidation of novel alkenone structures unique to the species, performing in-situ temperature calibrations, and classifying alkenone-producing haptophytes into three groups based on molecular ecological approaches (with the new species belonging to Group I Isochrysidales); (2) A global survey of Group I haptophyte distributions and environmental conditions favoring the presence of this alga, as well as examples of using Group I alkenones for paleotemperature reconstructions; (3) New gas chromatographic columns that allow unprecedented resolution of alkenones and alkenoates and associated structural isomers, and development of a new suite of paleotemperature and paleoenvironmental proxies; (4) A new liquid chromatographic separation technique that allows efficient cleanup of alkenones and alkenoates (without the need for saponification) for subsequent coelution-free gas chromatographic analysis; (5) Novel structural features revealed by new analytical methods that now allow a comprehensive re-assessment of taxonomic features of various haptophyte species, with principal component analysis capable of fully resolving species biomarker distributions; (6) Development of UK37 double prime (UK37'') for Group II haptophytes (e.g., those occurring in saline lakes and estuaries), that differs from the traditional unsaturation indices used for SST reconstructions; (7) New assessment of how mixed inputs from different alkenone groups may affect SST reconstructions in marginal ocean environments and

  16. New aspects on the structure of neutrophil extracellular traps from chronic obstructive pulmonary disease and in vitro generation.

    Directory of Open Access Journals (Sweden)

    Astrid Obermayer

    Full Text Available Polymorphonuclear neutrophils have in recent years attracted new attention due to their ability to release neutrophil extracellular traps (NETs. These web-like extracellular structures deriving from nuclear chromatin have been depicted in ambiguous roles between antimicrobial defence and host tissue damage. NETs consist of DNA strands of varying thickness and are decorated with microbicidal and cytotoxic proteins. Their principal structure has in recent years been characterised at molecular and ultrastructural levels but many features that are of direct relevance to cytotoxicity are still incompletely understood. These include the extent of chromatin decondensation during NET formation and the relative amounts and spatial distribution of the microbicidal components within the NET. In the present work, we analyse the structure of NETs found in induced sputum of patients with acutely exacerbated chronic obstructive pulmonary disease (COPD using confocal laser microscopy and electron microscopy. In vitro induced NETs from human neutrophils serve for purposes of comparison and extended analysis of NET structure. Results demonstrate that COPD sputa are characterised by the pronounced presence of NETs and NETotic neutrophils. We provide new evidence that chromatin decondensation during NETosis is most extensive and generates substantial amounts of double-helix DNA in 'beads-on-a-string' conformation. New information is also presented on the abundance and location of neutrophil elastase (NE and citrullinated histone H3 (citH3. NE occurs in high densities in nearly all non-fibrous constituents of the NETs while citH3 is much less abundant. We conclude from the results that (i NETosis is an integral part of COPD pathology; this is relevant to all future research on the etiology and therapy of the disease; and that (ii release of 'beads-on-a-string' DNA studded with non-citrullinated histones is a common feature of in vivo NETosis; this is of relevance to

  17. The complete chloroplast genome sequence of Podocarpus lambertii: genome structure, evolutionary aspects, gene content and SSR detection.

    Directory of Open Access Journals (Sweden)

    Leila do Nascimento Vieira

    Full Text Available BACKGROUND: Podocarpus lambertii (Podocarpaceae is a native conifer from the Brazilian Atlantic Forest Biome, which is considered one of the 25 biodiversity hotspots in the world. The advancement of next-generation sequencing technologies has enabled the rapid acquisition of whole chloroplast (cp genome sequences at low cost. Several studies have proven the potential of cp genomes as tools to understand enigmatic and basal phylogenetic relationships at different taxonomic levels, as well as further probe the structural and functional evolution of plants. In this work, we present the complete cp genome sequence of P. lambertii. METHODOLOGY/PRINCIPAL FINDINGS: The P. lambertii cp genome is 133,734 bp in length, and similar to other sequenced cupressophytes, it lacks one of the large inverted repeat regions (IR. It contains 118 unique genes and one duplicated tRNA (trnN-GUU, which occurs as an inverted repeat sequence. The rps16 gene was not found, which was previously reported for the plastid genome of another Podocarpaceae (Nageia nagi and Araucariaceae (Agathis dammara. Structurally, P. lambertii shows 4 inversions of a large DNA fragment ∼20,000 bp compared to the Podocarpus totara cp genome. These unexpected characteristics may be attributed to geographical distance and different adaptive needs. The P. lambertii cp genome presents a total of 28 tandem repeats and 156 SSRs, with homo- and dipolymers being the most common and tri-, tetra-, penta-, and hexapolymers occurring with less frequency. CONCLUSION: The complete cp genome sequence of P. lambertii revealed significant structural changes, even in species from the same genus. These results reinforce the apparently loss of rps16 gene in Podocarpaceae cp genome. In addition, several SSRs in the P. lambertii cp genome are likely intraspecific polymorphism sites, which may allow highly sensitive phylogeographic and population structure studies, as well as phylogenetic studies of species of

  18. Territorial Dioceses and Ethnic Episcopies in the Structure of the Church Organization of the First Bulgarian Kingdom (Canonical Aspects

    Directory of Open Access Journals (Sweden)

    Archpriest Alexander Zadornov

    2016-11-01

    Full Text Available The coexistence of ethnic and territorial principles in the structure of ecclesiastical organizations is a well known fact in church history. Both principles are equally legitimate from the point of view of canonical law. The “ethnic principle” was based on legal norms of the so-called 34th Apostolic Rule, and contrary to the opinion of scholars of the 19th century, it was still in use after the era of the Ecumenical Councils. This fact must be considered by students of the history of Church organizations in the First Bulgarian Kingdom, too. The observations regarding the structure of church organizations in Simeonic Bulgaria make it possible to assume the coexistence of ethnic and territorial principles of church organizations in his kingdom. As is known, Slavonic church schools were established in the southwestern part of the First Bulgarian Kingdom after 886. They were aimed at training the Slavonic clergy for the Slavonic church organization. In 893, the Bulgarian King Simeon was elevated to the throne, and a Slavonic eparchy headed by St. Clement of Ohrid was established in the southwestern territories of the First Bulgarian Kingdom. As a result, heterogeneous church organizations were established in the region, and church structures of ethnic and territorial types appeared. They differ from each other by the language of their church services. Old Church Slavonic must have been used as a liturgical language in the ethnic Slavonic eparchy. Since direct historical evidence for such heterogeneous church structure in the First Bulgarian Kingdom is absent, new interpretations of sources made on the basis of canonical law can be of importance for Slavonic studies.

  19. Investigating the structural changes of uranium dioxide dependent on additives, Phase I - Uranium-oxide system from structural-phase aspect

    International Nuclear Information System (INIS)

    Manojlovic, Lj.

    1962-12-01

    Having in mind the complex structure of the system uranium-oxygen, and that experimental studies of this system lead to controversial conclusions, an extensive review and analysis of the papers published on this subject were needed. This review wold be very useful for interpreting the expected structural changes of the uranium dioxide dependent on the additives

  20. Nonlinear fluid-structure interaction problem. Part II: space discretization, implementation aspects, nested parallelization and application examples

    Science.gov (United States)

    Kassiotis, Christophe; Ibrahimbegovic, Adnan; Niekamp, Rainer; Matthies, Hermann G.

    2011-03-01

    The main focus of the present article is the development of a general solution framework for coupled and/or interaction multi-physics problems based upon re-using existing codes into software products. In particular, we discuss how to build this software tool for the case of fluid-structure interaction problem, from finite element code FEAP for structural and finite volume code OpenFOAM for fluid mechanics. This is achieved by using the Component Template Library (CTL) to provide the coupling between the existing codes into a single software product. The present CTL code-coupling procedure accepts not only different discretization schemes, but different languages, with the solid component written in Fortran and fluid component written in C++ . Moreover, the resulting CTL-based code also accepts the nested parallelization. The proposed coupling strategy is detailed for explicit and implicit fixed-point iteration solver presented in the Part I of this paper, referred to Direct Force-Motion Transfer/Block- Gauss-Seidel. However, the proposed code-coupling framework can easily accommodate other solution schemes. The selected application examples are chosen to confirm the capability of the code-coupling strategy to provide a quick development of advanced computational tools for demanding practical problems, such as 3D fluid models with free-surface flows interacting with structures.

  1. Binding of the anticancer alkaloid sanguinarine to double stranded RNAs: insights into the structural and energetics aspects.

    Science.gov (United States)

    Chowdhury, Sebanti Roy; Islam, Md Maidul; Kumar, Gopinatha Suresh

    2010-07-01

    Elucidation of the molecular aspects of small molecule-RNA complexation is of prime importance for rational RNA targeted drug design strategies. Towards this, the interaction of the cytotoxic plant alkaloid sanguinarine to three double stranded ribonucleic acids, poly (A).poly(U), poly(I).poly(C) and poly(C).poly(G) was studied using various biophysical and thermodynamic techniques. Absorbance and fluorescence studies showed that the alkaloid bound cooperatively to these RNAs with binding affinities of the order 10(4) M(-1). Fluorescence quenching and hydrodynamic studies gave evidence for intercalation of sanguinarine to these RNA duplexes. Isothermal titration calorimetric studies revealed that the binding was characterized by negative enthalpy and positive entropy changes and the affinity constants derived were in agreement with the overall binding affinity values obtained from spectroscopic data. The binding of sanguinarine stabilized the melting of poly(A). poly(U) and poly(I).poly(C) and the binding data evaluated from the melting data were in agreement with that obtained from other techniques. The overall binding affinity of sanguinarine to these double stranded RNAs varied in the order, poly(A).poly(U) > poly(I).poly(C) > poly(C).poly(G). The temperature dependence of the enthalpy changes afforded negative values of heat capacity changes for the binding of sanguinarine to poly(A).poly(U) and poly(I).poly(C), suggesting substantial hydrophobic contribution in the binding process. Further, enthalpy-entropy compensation phenomena was also seen in poly(A).poly(U) and poly(I).poly(C) systems that correlated to the strong binding involving a multiplicity of weak noncovalent interactions compared to the weak binding with poly(C).poly(G). These results further advance our understanding on the binding of small molecules that are specific binders to double stranded RNA sequences.

  2. Electronic and structural aspects of spin transitions observed by optical microscopy. The case of [Fe(ptz)6](BF4)2.

    Science.gov (United States)

    Chong, Christian; Mishra, Haritosh; Boukheddaden, Kamel; Denise, Stéphane; Bouchez, Guillaume; Collet, Eric; Ameline, Jean-Claude; Naik, Anil D; Garcia, Yann; Varret, François

    2010-02-11

    The colorimetric analysis of images recorded with an optical microscope during the onset of the spin crossover transformation allows monitoring separately the involved electronic and structural aspects, through the separation of resonant absorption and scattering effects. Complementary information can also be obtained by using the polarized modes of the microscope. These potentialities are illustrated by the observation of [Fe(ptz)(6)](BF(4))(2) single crystals during the onset of the thermal transitions in the 110-140 K range. We characterized the interplay between the electronic (HS LS) and structural (order disorder) transformations. Elastic stresses and mechanical effects (hopping, self-cleavage) generated by the volume change upon electronic transition are also illustrated, with their impact on the photoswitching properties of the crystals.

  3. Large scale structures of a turbulent Rayleigh-Bénard convection in a liquid metal layer confined by a moderate aspect ratio box

    Science.gov (United States)

    Akashi, Megumi; Tasaka, Yuji; Yanagisawa, Takatoshi; Murai, Yuichi; Vogt, Tobias; Eckert, Sven

    2017-11-01

    We report laboratory experiments of Rayleigh-Bénard convection with a liquid metal, Prandtl number Pr = 0.03, in a rectangular cell at a moderate aspect ratio of 5. The Rayleigh number, Ra, was varied in a range from 7.9-103 to 3.5-105 in which the regime of thermal turbulence regime is to be expected. Multiple horizontal velocity profiles were measured in the fluid layer by ultrasonic velocity profiling. The reconstruction of the flow pattern elucidated the occurrence of large scale structures with periodic oscillations. An increasing Ra number causes a transition from a quasi-two-dimensional roll-like structure to a three-dimensional cell-like structure. The transition of the flow structure passes several unstable intermediate regimes accompanied by a stepwise increase of the horizontal scale. For explaining the increase in the horizontal scale, we suggest a model relying on observed Ra dependences of the oscillation frequency and the typical flow velocity of the large scales. Moreover, we have found that the morphology of the roll-like structure can be understood by evaluating the effective viscosity and diffusivity on the basis of turbulent fluctuations.

  4. Structural and thermodynamic aspects of the dissociation of cyclopentadienyl rings from homoleptic cyclopentadienyl early transition metal, cerium, and thorium derivatives

    International Nuclear Information System (INIS)

    Peng Bin; Cheng Feng; Li Qianshu; Xie Yaoming; King, R. Bruce; Schaefer, Henry F.

    2011-01-01

    Graphical abstract: Density functional theory indicates that for Cp 4 M the S 4 structures are saddle points and the minima have C 1 symmetry with all η 5 -Cp rings for M = Ce and Th, three η 5 -Cp rings and one η 5 -Cp ring for M = Zr, and two η 5 -Cp rings and two η 5 -Cp rings for M = Ti and Hf. The dissociation energies for Cp 4 M → Cp 3 M + Cp · increase in the sequence Ti 3h structures with all η 5 -Cp rings are genuine minima for most of the Cp 3 M compounds except for Cp 3 Ti, which has a Cs symmetry minimum with two η 5 -Cp rings and one η 2 -Cp ring. The dissociation energies for Cp 3 M → Cp 2 M + Cp · increase in the sequence V 4 M the S 4 structures are saddle points. → The minima for Cp 4 M have all η 5 -Cp rings for M = Ce and Th, three η 5 -Cp rings and one η 1 -Cp ring for M = Zr, and two η 5 -Cp rings and two η 5 -Cp rings for M = Ti and Hf. → The dissociation energies for Cp 4 M → Cp 3 M + Cp · increase in the sequence Ti 3h structures with all η 5 -Cp rings are genuine minima for all of the Cp 3 M compounds except for Cp 3 Ti. → The dissociation energies for Cp 3 M → Cp 2 M + Cp · increase in the sequence V 4 M (M = Ti, Zr, Ce, Hf, Th), Cp 3 M (M = Sc, Y, most lanthanides, Ti, Zr, Hf, Th), and Cp 2 M (M = Ti, V). Density functional theory shows that the Cp 4 M structures with unusual S 4 symmetry are saddle points for the d-block metals Ti, Zr, Hf but genuine minima for the f-block metals Ce and Th. The true equilibrium Cp 4 M geometries have C 1 symmetry with two η 5 -Cp rings and two η 1 -Cp rings for M = Ti and Hf but three η 5 -Cp rings and one η 1 -Cp ring for M = Zr. The dissociation energies for Cp 4 M → Cp 3 M + Cp · are substantial and in the order Ti 3h structures with all η 5 -Cp rings are genuine minima for most of the Cp 3 M compounds except for Cp 3 Ti, which has a C s symmetry minimum with two η 5 -Cp rings and one η 2 -Cp ring, and Cp 3 V, which has two η 5 -Cp rings and one η 1 -Cp ring

  5. The Effects of Information Technology on Library and Documentation Centers: A Review of Social, Structural, Managerial and Functional Aspects

    Directory of Open Access Journals (Sweden)

    Mesut Kurulgan

    2013-11-01

    Full Text Available In the context of protecting academic and cultural heritage, the purpose of libraries and information and documentation centers is to research, document, and archive and to transfer to future generations, domestically and internationally, a society ’s culture. This study examines the structural, functional and administrative innovations that have resulted from the implementation of information technology (IT in libraries since the 1990 ’s. The study also mentions how IT can be used in an efficient way in libraries and information and documentation centers.

  6. αB-Crystallin: A Hybrid Solid-Solution State NMR Investigation Reveals Structural Aspects of the Heterogeneous Oligomer

    OpenAIRE

    Jehle, Stefan; van Rossum, Barth; Stout, Joseph R.; Noguchi, Satoshi R.; Falber, Katja; Rehbein, Kristina; Oschkinat, Hartmut; Klevit, Rachel E.; Rajagopal, Ponni

    2008-01-01

    Atomic level structural information on αB-Crystallin (αB), a prominent member of the small Heat Shock Protein (sHSP) family has been a challenge to obtain due its polydisperse, oligomeric nature. We show that magic-angle spinning solid-state NMR can be used to obtain high-resolution information on ∼ 580 kDa human αB assembled from 175-residue, 20 kDa subunits. An ∼100-residue α-crystallin domain is common to all sHSPs and solution-state NMR was performed on two different α-crystallin domain c...

  7. Study of the electroforming technology for high-aspect ratio micro structure which was machined by using proton beam writing

    International Nuclear Information System (INIS)

    Okamoto, N.

    2009-01-01

    In this study, we develop the formation process of Ni electrodeposited micro patterns, which is used for MEMS devices or nano-imprinting. The purpose of my study is creating the new process of fabricating 3-D complicated micro-pattern or micro-devices using electroforming and proton beam writing. In general, 'Through mask process' (like a LIGA process) is usually used to fabricate Ni electrodeposited micro patterns for making MEMS devices or microfabricated-molds. The strong point of 'Through mask process' is the simple shape of the electrode. It makes the deposition process easy, because the electrodeposited films just glow up from the bottom to top surface of the mold. And the shape of the electrodeposited films is the same as the electrode pattern from the bottom to top, like a simple pillar shape. However, this process also has some problems. In case of using 'Through mask process', it is difficult to fabricate the complicated 3-D shaped structures, which are bended, parted or severed at some part of the structure between the bottom and top, like a device with a micro sensor or micro total analysis system. In order to overcome these limitations, we try to fabricate Ni electrodeposited micro patterns using 'the Damascene process' and proton beam writing. (author)

  8. Hydrologic aspects of marsh ponds during winter on the Gulf Coast Chenier Plain, USA: Effects of structural marsh management

    Science.gov (United States)

    Bolduc, F.; Afton, A.D.

    2004-01-01

    The hydrology of marsh ponds influences aquatic invertebrate and waterbird communities. Hydrologic variables in marsh ponds of the Gulf Coast Chenier Plain are potentially affected by structural marsh management (SMM: levees, water control structures and impoundments) that has been implemented since the 1950s. Assuming that SMM restricts tidal flows and drainage of rainwater, we predicted that SMM would increase water depth, and concomitantly decrease salinity and transparency in impounded marsh ponds. We also predicted that SMM would increase seasonal variability in water depth in impounded marsh ponds because of the potential incapacity of water control structures to cope with large flooding events. In addition, we predicted that SMM would decrease spatial variability in water depth. Finally, we predicted that ponds of impounded freshwater (IF), oligohaline (IO), and mesohaline (IM) marshes would be similar in water depth, temperature, dissolved oxygen (O2), and transparency. Using a priori multivariate analysis of variance (MANOVA) contrast, we tested these predictions by comparing hydrologic variables within ponds of impounded and unimpounded marshes during winters 1997-1998 to 1999-2000 on Rockefeller State Wildlife Refuge, near Grand Chenier, Louisiana. Specifically, we compared hydrologic variables (1) between IM and unimpounded mesohaline marsh ponds (UM); and (2) among IF, IO, and IM marshes ponds. As predicted, water depth was higher and salinity and O2 were lower in IM than in UM marsh ponds. However, temperature and transparency did not differ between IM and UM marsh ponds. Water depth varied more among months in IM marsh ponds than within those of UM marshes, and variances among and within ponds were lower in IM than UM marshes. Finally, all hydrologic variables, except salinity, were similar among IF, IO, and IM marsh ponds. Hydrologic changes within marsh ponds due to SMM should (1) promote benthic invertebrate taxa that tolerate low levels of O2 and

  9. The eversible tentacle organs of Polyommatus caterpillars (Lepidoptera, Lycaenidae): Morphology, fine structure, sensory supply and functional aspects.

    Science.gov (United States)

    Gnatzy, W; Jatho, M; Kleinteich, T; Gorb, S N; Hustert, R

    2017-11-01

    In their late (3rd and 4th) larval stages, caterpillars of the myrmecophilous lycaenid (Lepidoptera) species Polyommatus coridon and Polyommatus icarus, possess on their 8th abdominal segment two eversible so called tentacle organs (TOs). Previous histological and behavioural results have proposed that the TOs may release a volatile substance that elicits "excited runs" in attendant ants. In our study we investigated for the first time the temporal in- and eversion pattern of TOs. Using nerve tracing, Micro-CT, light- and electron microscopy techniques we studied (i) the histology of the 8th abdominal segment, (ii) the fine structure of the cuticular and cellular apparatus of the TOs, (iii) the attachment sites of the retractor muscle of each TO and (iv) the fine structure of the long slender tentacle hairs which are exposed to the outside, when the TOs are everted and fold back into the TO-sac during inversion. Our data show that the tentacle hairs are typical insect mechanoreceptors, each innervated by a small bipolar sensory cell with a tubular body in the tip of the outer dendritic segment. The latter is enclosed by a cuticular sheath previously called the "internal cuticular duct" and misinterpreted in earlier studies as the space, where the tentacle hairs actively secrete fluids. However, we found no glandular structures nearby or in the wall of the TO-sac. Also we did not reveal any conspicuous signs of secretory activity in one of the enveloping cells belonging to a tentacle hair. Although highly unusual features for an insect mechanoreceptor are: (a) the hair-shaft lumen of tentacle hairs contains flocculent material as well small vesicles and (b) the thin cuticular wall of the hair-shaft and its spines possess few tiny pores. Our data do not support the assumption of previous studies that volatile substances are released via the tentacle organs during their interactions with ants which in turn are supposed to cause excited runs in ants. Copyright © 2017

  10. Structural aspects of the solvation shell of lysine and acetylated lysine: A Car-Parrinello and classical molecular dynamics investigation

    International Nuclear Information System (INIS)

    Carnevale, V.; Raugei, S.

    2009-01-01

    Lysine acetylation is a post-translational modification, which modulates the affinity of protein-protein and/or protein-DNA complexes. Its crucial role as a switch in signaling pathways highlights the relevance of charged chemical groups in determining the interactions between water and biomolecules. A great effort has been recently devoted to assess the reliability of classical molecular dynamics simulations in describing the solvation properties of charged moieties. In the spirit of these investigations, we performed classical and Car-Parrinello molecular dynamics simulations on lysine and acetylated-lysine in aqueous solution. A comparative analysis between the two computational schemes is presented with a focus on the first solvation shell of the charged groups. An accurate structural analysis unveils subtle, yet statistically significant, differences which are discussed in connection to the significant electronic density charge transfer occurring between the solute and the surrounding water molecules.

  11. Structural aspects and floristic similarity among tropical dry forest fragments with different management histories in northern Minas Gerais, Brazil

    Directory of Open Access Journals (Sweden)

    Daniel Meira Arruda

    2011-02-01

    Full Text Available In order to produce useful knowledge to the initiatives of protection and management of forest fragments, more specifically for tropical dry forests which suffer with frequent anthropic activities, and due to the lack of specific studies, this article aimed describe the structure and the floristic similarity among three areas of dry forest with different management histories. The study was developed in Capitão Enéas municipality, Northern Minas Gerais, Brazil, where three fragments were evaluated, being one in regeneration for 30 years, another submitted to occasional fire and the third with selective cut in small scale. The sampling was developed through the point quarter method considering all the alive phanerophyte individuals with circumference at breast height (CBH > 15 cm. In the three fragments, 512 individuals, distributed in 60 species, 47 genera, and 23 families were sampled. The most representative families were Fabaceae (26, Anacardiaceae (4, Bignoniaceae (3 and Combretaceae (3. However, fourteen families were represented by only one species. Only eight species were common to all fragments - Myracrodruon urundeuva standed out with 26.9% of all sampled individuals - while a great number of species were exclusive of each fragment. The floristic and structural differences between the fragments are possibly related to the history and intensity of management in each area besides the topography variations and the presence or absence of limestone outcrops. These results show the importance of each fragment, indicating that the loss of anyone would cause negative impacts on the regional flora and consequently to the associated biodiversity.

  12. Structures of intermediates along the catalytic cycle of terminal deoxynucleotidyltransferase: dynamical aspects of the two-metal ion mechanism.

    Science.gov (United States)

    Gouge, Jérôme; Rosario, Sandrine; Romain, Félix; Beguin, Pierre; Delarue, Marc

    2013-11-15

    Terminal deoxynucleotidyltransferase (Tdt) is a non-templated eukaryotic DNA polymerase of the polX family that is responsible for the random addition of nucleotides at the V(D)J junctions of immunoglobulins and T-cell receptors. Here we describe a series of high-resolution X-ray structures that mimic the pre-catalytic state, the post-catalytic state and a competent state that can be transformed into the two other ones in crystallo via the addition of dAMPcPP and Zn(2+), respectively. We examined the effect of Mn(2+), Co(2+) and Zn(2+) because they all have a marked influence on the kinetics of the reaction. We demonstrate a dynamic role of divalent transition metal ions bound to site A: (i) Zn(2+) (or Co(2+)) in Metal A site changes coordination from octahedral to tetrahedral after the chemical step, which explains the known higher affinity of Tdt for the primer strand when these ions are present, and (ii) metal A has to leave to allow the translocation of the primer strand and to clear the active site, a typical feature for a ratchet-like mechanism. Except for Zn(2+), the sugar puckering of the primer strand 3' terminus changes from C2'-endo to C3'-endo during catalysis. In addition, our data are compatible with a scheme where metal A is the last component that binds to the active site to complete its productive assembly, as already inferred in human pol beta. The new structures have potential implications for modeling pol mu, a closely related polX implicated in the repair of DNA double-strand breaks, in a complex with a DNA synapsis. © 2013.

  13. Structural aspects of the formation of solid solutions in the NaF-KF-AlF3 system

    Science.gov (United States)

    Samoilo, Alexander S.; Zaitseva, Yulia N.; Dubinin, Peter S.; Piksina, Oksana E.; Ruzhnikov, Sergei G.; Yakimov, Igor S.; Kirik, Sergei D.

    2017-08-01

    The formation of solid solutions in the ternary system NaF-KF-AlF3 has been studied by X-ray diffraction and thermal analysis. Chiolite has been shown to form solid solutions with the composition (Na(5-x)Kx)Al3F14, in the limited range of 0structure, potassium cations substitute sodium only in the 2-fold position in the amount of 40%. The solid solutions are stable in the range from room to melting point temperature. A wide range of solid solutions based on β-cryolite (Na3AlF6) and elpasolite (K2NaAlF6) above 540 °C has been studied in detail. It is only the 8-fold cationic position in the β-cryolite structure which appears to have contributed into the substitution in the full range of solid solutions. The solid solution decays into a mixture of α-Na3AlF6 and K2NaAlF6 upon calcination below 540 °C., followed by further cooling without changing the α-Na3AlF6 composition. Elpasolite initially containing an excess of sodium ions, has yielded cryolite and stoichiometric K2NaAlF6 below 340 °C. The phase K2NaAl3F12 present in two polymorphic forms, has not formed a wide range of solid solutions; however, a slight excess of potassium ions has improved the stability of the high-temperature form.

  14. Effects of 137Cs and 90Sr on structure and functional aspects of the microflora in agricultural used soils

    International Nuclear Information System (INIS)

    Niedree, Bastian

    2013-01-01

    At long sight 137 Cs and 90 Sr are the main radionuclides responsible for the contamination of agricultural soils due to core melts in nuclear power plants such as Chernobyl or Fukushima. Once deposited on the soil surface, the two radionuclides remain in the upper soil layer for several decades. In the upper soil layer the highest microbial activity can be found, due to high organic matter contents, warm temperatures and gas exchange with the atmosphere. Hence, in contaminated soils microorganisms in upper soil layers (e.g. the plow layer on agricultural fields) are exceedingly exposed to radioactivity. However, no data are available how radioactive contaminations with 137 Cs or 90 Sr in a realistic order of magnitude affect the microbial community and its functions in soils. This dissertation discusses the effects of radioactive contaminations on the microbial community structure and some of its functions in soils. Therefore, typical agricultural soils, an Orthic Luvisol from field site Merzenhausen and a Gleyic Cambisol from field site Kaldenkirchen-Huelst were artificially contaminated with various concentrations of 137 Cs and 90 Sr and partly applied with radiolabeled substrates and incubated in soil microcosms under controlled laboratory conditions. The lower radionuclide concentrations corresponded to the contaminations in the Chernobyl exclusion zone, the higher concentrations were up to 50-fold that of the maximum occurring hotspots ( 137 Cs) in this zone. In three experiments the effects of the ionizing radiation on the bacterial and the fungal community structure (16S and 18S rDNA DGGE), the degradation of 14 C-labeled wheat straw or uniformly ring-labeled 2,4-dichlorophenoxyacetic acid, the development of the fungal biomass (ergosterol quantification) and the chemical composition of the soil organic matter ( 13 C CP/MAS NMR) were investigated. In half of the microcosms the soils were autoclaved and reinoculated with native soil, with intention to

  15. αB-Crystallin. A Hybrid Solid-State/Solution-State NMR Investigation Reveals Structural Aspects of the Heterogeneous Oligomer

    Energy Technology Data Exchange (ETDEWEB)

    Jehle, Stefan [Freie Univ., Berlin (Germany); Leibniz Inst. for Molecular Pharmacology, Berlin (Germany); van Rossum, Barth [Leibniz Inst. for Molecular Pharmacology, Berlin (Germany); Stout, Joseph R. [Univ. of Washington, Seattle, WA (United States); Noguchi, Satoshi M. [Univ. of Washington, Seattle, WA (United States); Falber, Katja [Leibniz Inst. for Molecular Pharmacology, Berlin (Germany); Rehbein, Kristina [Leibniz Inst. for Molecular Pharmacology, Berlin (Germany); Oschkinat, Hartmut [Freie Univ., Berlin (Germany); Leibniz Inst. for Molecular Pharmacology, Berlin (Germany); Klevit, Rachel E. [Univ. of Washington, Seattle, WA (United States); Rajagopal, Ponni [Univ. of Washington, Seattle, WA (United States)

    2008-11-14

    Atomic-level structural information on αB-Crystallin (αB), a prominent member of the small heat-shock protein family, has been a challenge to obtain due its polydisperse oligomeric nature. We show that magic-angle spinning solid-state NMR can be used to obtain high-resolution information on an ~580-kDa human αB assembled from 175-residue 20-kDa subunits. An ~100-residue α-crystallin domain is common to all small heat-shock proteins, and solution-state NMR was performed on two different α- crystallin domain constructs isolated from αB. In vitro, the chaperone-like activities of full-length αB and the isolated α-crystallin domain are identical. Chemical shifts of the backbone and Cβ resonances have been obtained for residues 64–162 (α-crystallin domain plus part of the C-terminus) in αB and the isolated α-crystallin domain by solid-state and solution-state NMR, respectively. Both sets of data strongly predict six β-strands in the α-crystallin domain. A majority of residues in the α-crystallin domain have similar chemical shifts in both solid-state and solution-state, indicating similar structures for the domain in its isolated and oligomeric forms. Sites of intersubunit interaction are identified from chemical shift differences that cluster to specific regions of the α-crystallin domain. Multiple signals are observed for the resonances of M68 in the oligomer, identifying the region containing this residue as existing in heterogeneous environments within αB. Evidence for a novel dimerization motif in the human α-crystallin domain is obtained by a comparison of (i) solid-state and solution-state chemical shift data and (ii) 1H–15N heteronuclear single quantum coherence spectra as a function of pH. The isolated α-crystallin domain undergoes a dimer–monomer transition over the pH range 7.5–6.8. This steep pHdependent switch may be important for αB to function optimally (e.g., to preserve the filament integrity

  16. Fission-fusion and lineal effect: aspects of the population structure of the Semai Senoi of Malaysia.

    Science.gov (United States)

    Fix, A G

    1975-09-01

    Analysis of histories and genealogies from seven relatively unacculturated, swidden-farming Semai settlements shows that the composition of local groups fluctuates through time. This instability is similar to a pattern which Neel and his colleagues have suggested is typical of primitive society, the fission-fusion model. In addition, the individuals comprising Semai fission groups are kinsmen which implies that the number of independent genomes represented is markedly less than the number of individual migrants (the lineal effect). Fission groups may form new villages or fuse with an established settlement. In either case, the genetic effects of such migration are more pronounced than would be expected on the basis of founder effect or random migration. Despite several conspicuous differences in social organization between the Semai and the South American Indians (e.g., bilateral vs. unilineal descent) whose population structure provided the empirical basis for the fission-fusion, lineal effect model, the basic similarities are striking. The Semai case thus lends support to the proposition that this pattern may be of some generality in technologically primitive populations.

  17. Research and Evaluations of the Health Aspects of Disasters, Part IV: Framework for Societal Structures: the Societal Systems.

    Science.gov (United States)

    Birnbaum, Marvin L; Daily, Elaine K; O'Rourke, Ann P

    2015-12-01

    For the purposes of research and/or evaluation, a community/society is organized into 13 Societal Systems under the umbrella of an overall Coordination and Control System. This organization facilitates descriptions of a community/society or a component of a community for assessment at any designated time across the Temporal Phases of a disaster. Such assessments provide a picture of the functional status of one or more Systems that comprise a community. Since no system operates in isolation from the other systems, information of the concomitant status of several Societal Systems is crucial to gaining a complete understanding of compromised functions, as well as the effects and side effects of any intervention directed at restoring the functional state of the affected community or risk-reduction interventions of a community-at-risk. The 13 Societal Systems include: (1) Public Health; (2) Medical Care; (3) Water and Sanitation; (4) Shelter and Clothing; (5) Food and Nutrition; (6) Energy Supply; (7) Public Works and Engineering; (8) Social Structures; (9) Logistics and Transportation; (10) Security; (11) Communications; (12) Economy; and (13) Education. Many functions and sub-functions of the Systems overlap, or share some common sub-functions with other systems. For the purposes of research/evaluation, it is necessary to assign functions and sub-functions to only one of the Societal Systems.

  18. Legal aspects of financing solar-heated residential structures. Final report of Innovative Research Program Subtask, December 1977-September 1978

    Energy Technology Data Exchange (ETDEWEB)

    Hiller, R.L.

    1978-10-01

    Through both interviews with primary and secondary mortgage market lending institutions and a search of the relevant literature, the major concerns and attitudes of financial institutions toward solar homes are reviewed, unique problems encountered in making loans on such structures are discussed and special requirements placed upon solar home loans are explored. At present, these are seen as centered around: (1) placing an appropriate valuation on a solar-heated home, (2) assessing the technical feasibility of a solar energy system, and (3) determining what energy savings might accrue through installation of a solar energy system and how such savings can best be integrated into the lending process. Some of the most pertinent literature on this subject is reviewed and the goals to be strived for in protecting solar access are set forth. Negative solar easements and restrictive covenants are seen as the most appropriate legal tools for assuring adequate solar access. Seven elements which must be addressed when describing the air space to be protected by an effective easement or covenant are identified. Appendices are included which show how one innovative lending institution has developed a policy for financing solar homes based upon these elements. Problems with regard to obtaining title insurance are discussed, and the enforceability and transferability of solar access rights are detailed.

  19. Functional Aspects of the Solution Structure and Dynamics of PAF, a Highly Stable Antifungal Protein from Penicillium chrysogenum

    Science.gov (United States)

    Batta, Gyula; Barna, Teréz; Gáspári, Zoltán; Sándor, Szabolcs; Kövér, Katalin E.; Binder, Ulrike; Sarg, Bettina; Kaiserer, Lydia; Chhillar, Anil Kumar; Eigentler, Andrea; Leiter, Éva; Hegedüs, Nikoletta; Pócsi, István; Lindner, Herbert; Marx, Florentine

    2015-01-01

    Summary PAF is a promising antimycotic without toxic effects on mammalian cells and therefore may be a drug candidate against the often lethal Aspergillus infections in human. The pathogenesis of PAF on sensitive fungi involves G-protein coupled signaling followed by apoptosis. Here, the solution structure of this small, cationic, antifungal protein from Penicillium chrysogenum is determined by solution NMR. We proved that PAF belongs to the SCOP fold class of its closest homologue AFP from Aspergillus giganteus. PAF comprises five β—strands forming two orthogonally packed β—sheets sharing a common interface. The ambiguity in the assignment of two disulfide bonds of three was investigated by NMR dynamics combined with restrained molecular dynamics calculations. The clue could not be resolved: two ensembles with different disulfide patterns and the one with no S-S bond exhibit essentially the same fold. 15N relaxation dispersion and interference experiments did not reveal disulfide bond rearrangements via slow exchange. The measured order parameters and the 3.0 ns correlation time is appropriate for a compact monomeric protein of this size. We demonstrated by site-directed mutagenesis that the highly conserved and positively charged lysine-rich domain region on the surface enhances the toxicity of PAF. However, the efficacy of the OB fold is reduced in PAF compared to AFP, due to less solvent exposed aromatic regions explaining the absence of chitobiose binding. The present work lends further support to the understanding of the documented substantial differences between the mode of action of two highly homologous antifungal proteins. PMID:19459942

  20. Structural aspects of graphitic carbon modified SBA-15 mesoporous silica and biological interactions with red blood cells and plasma proteins.

    Science.gov (United States)

    Martinez, Diego S T; Damasceno, João Paulo V; Franqui, Lidiane S; Bettini, Jefferson; Mazali, Italo O; Strauss, Mathias

    2017-09-01

    Functional mesoporous materials have been worldwide studied for different applications. Mesoporous silicas are highlighted due to the synthetic possibilities for the preparation of such materials with different particle sizes and morphologies, and controlled pores sizes and structures. Moreover, the silica superficial silanol groups are explored in several chemical modifications, leading to functional materials with tuned functionalities and properties. In this work, an organo-functionalization and pyrolysis synthetic procedure is used to obtain graphitic carbon modified mesoporous SBA-15 silica. The carbon content was tuned during the functionalization step, and the graphitic nanodomains were formed in the pores surface and particles outer surface. Textural and small angle X-ray diffraction analysis accessed the presence of the carbon nanostructures inside the SBA-15 mesopores. Advanced microanalysis using electron energy loss spectroscopy coupled to a transmission electron microscope had confirmed the carbon distribution along the silica pores, which gives higher hydrophobicity and changed the interaction of the mesoporous material with biological systems. Finally, the influence of the surface modification with graphitic carbon species over the interaction with human red blood cells (hemolysis) and human blood plasma (protein corona formation) was elucidated for the very first time for this kind of functional materials. It was observed that the graphitic carbon species considerably reduced the hemolytic effect of the silica particles, and was responsible for modulating the loading and composition of the hard corona plasma proteins. This work deepness the fundamental knowledge on the interaction between such nanomaterials and biological systems, one step further the use of these modified silicas in biomedical applications. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Aspects of the distribution, population structure and reproduction of the gastropod Tibia delicatula (Nevill, 1881) inhabiting the oxygen minimum zone of the Oman and Pakistan continental margins

    Science.gov (United States)

    Ramirez-Llodra, Eva; Olabarria, Celia

    2005-11-01

    The present study describes some aspects of the distribution and biology of Tibia delicatula (Nevill), a gastropod belonging to the family Strombidae. This species has been found in large numbers in the upper oxygen minimum zone (OMZ) of the Oman margin, and has also been collected from the OMZ of the Pakistan margin. The highest abundance of adult specimens in the Oman OMZ was found between 300 and 450 m. Numbers dropped rapidly below 450 m, to zero below 500 m depth. Similarly dense populations were not observed in the Pakistan OMZ. Multiple regression with oxygen concentration and depth indicates that depth (and its related variables) is the main factor explaining the variation in abundance of T. delicatula. The populations from the Oman and Pakistan OMZs were dominated by juveniles. This suggests a unimodal size structure with evidence of a marked recruitment event. Basic reproductive aspects were analysed. All specimens had a penis and sperm groove. The gonad wall consisted of reticular tissue that might be used for nutrient storage or as an irrigation system. Only vitellogenic oocytes were present. The large oocyte sizes observed (200-300 μm) suggest a lecithotrophic larval development.

  2. Student assessment of teaching as a source of information about aspects of teaching quality in multiple subject domains: an application of multilevel bifactor structural equation modeling

    Science.gov (United States)

    Scherer, Ronny; Gustafsson, Jan-Eric

    2015-01-01

    Research on educational effectiveness most often uses student assessments of classroom instruction for measuring aspects of teaching quality. Given that crucial inferences on the success of education are based on these assessments, it is essential to ensure that they provide valid indicators. In this study, we illustrate the application of an innovative application of a multilevel bifactor structural equation model (ML-BFSEM) to examine the validity of student assessments. Analyzing a large-scale data set of 12,077 fourth-grade students in three countries (Finland, Norway, and Sweden), we find that (i) three aspects of teaching quality and subject domain factors can be established; (ii) metric and scalar invariance could be established for the ML-BFSEM approach across countries; and (iii) significant relations between students’ assessments of how easy the teacher is to understand and achievement in all subjects exist. In support of substantive research, we demonstrate a methodological approach for representing the complex nature of student assessments of teaching quality. We finally encourage substantive and methodological researchers to advance the ML-BFSEM. PMID:26500599

  3. Aspects of the structural and late thermal evolution of the Redbank Thrust system, central Australia: constraints from the Speares Metamorphics

    International Nuclear Information System (INIS)

    Biermeier, C.; Wiesinger, M.; Stuewe, K.; Foster, D.A.

    2003-01-01

    We present new data on the field geology and late thermal evolution of the Redbank Thrust system in the Arunta Block of central Australia. Geochronological and field data from the Speares Meta-morphics are also used to relate the thermal evolution of the Redbank Thrust system to the structural evolution of the region. We show that several stages in the evolution might be discerned. An originally sedimentary sequence was intruded by mafic intrusions and then deformed during partial melting to form the principal foliation observed in the region (D1). This sequence was then folded during D2 into upright folds with north- to northeast-plunging fold axes. These events are likely to correlate with the Strangways and/or Argilke and Chewings Orogenies known from previous studies. Subsequently, the Redbank Thrust was initiated during D3. This event is recognised by deflection of the host rocks into the shear zone and might therefore have been associated with a component of strike-slip motion. It occurred probably at or before 1500-1400 Ma. Subsequent north-over-south thrust motion in the Redbank Thrust formed the intense mylonitic fabric and folded the mylonitic fabric during D4 into asymmetric folds with shallow fold axes. New 40 Ar/ 39 Ar K-feldspar ages from three samples collected from variably deformed branches of the Redbank Thrust and undeformed rocks in the Speares Metamorphics suggest that most parts of the Redbank Thrust system cooled relatively slowly after metamorphism and deformation in the Mesoproterozoic so that the D4 thrusting might have been very long-lived. Minimum ages of the K-feldspar age spectra show that the entire region cooled below 200 deg C by approximately 300 Ma. Apatite fission track ages from nine samples show that cooling through the apatite partial annealing zone occurred during Cretaceous time (ca 150-70 Ma) and modelled cooling histories are consistent with the cooling rates obtained from the K-feldspar data. They indicate that final

  4. Cross-cultural opening in German outpatient mental healthcare service: an exploratory study of structural and procedural aspects.

    Science.gov (United States)

    Mösko, Mike-Oliver; Gil-Martinez, Fernanda; Schulz, Holger

    2013-01-01

    Mental healthcare services need to be sensitive towards the cultural needs of patients. Cross-cultural opening is an organizational process to fulfil these needs. This study aims to provide representative structural and procedural data regarding the use of German outpatient mental healthcare services by allochthonous patients, the diversity of psychotherapists in outpatient mental healthcare service, the cross-cultural encounters of therapists and the cross-cultural sensitivity of psychotherapists working in this healthcare area. Of all public outpatient psychotherapists in Hamburg, 81% (n = 485) participated in this survey. Regarding the distribution of the population in this metropolis, allochthonous therapists were underrepresented. Unlike the overall distribution of foreign inhabitants, the largest groups of immigrant therapists came from England, German-speaking countries and other countries within the European Union. The proportion of allochthonous patients in outpatient mental healthcare service was almost half of the proportion of the allochthonous in the general population. Psychotherapists with a migration background regarded themselves as having a higher level of cross-cultural sensitivity than their native colleagues, especially those who have had fewer cross-cultural encounters. Overall, psychotherapists named different challenges in providing cross-cultural treatment. For the German outpatient mental healthcare service to be more accessible to immigrants and their descendants, a greater number of bilingual psychotherapists must gain access to the mental healthcare service, and more advanced cross-cultural sensitivity training and supervision should be provided. German outpatient psychotherapists are culturally and linguistically diverse. Nevertheless, psychotherapists with a migration background are underrepresented in outpatient mental healthcare services. Patients with a migration background are also underrepresented in the German outpatient mental

  5. Molecular dynamics simulations and structure-based network analysis reveal structural and functional aspects of G-protein coupled receptor dimer interactions

    Science.gov (United States)

    Baltoumas, Fotis A.; Theodoropoulou, Margarita C.; Hamodrakas, Stavros J.

    2016-06-01

    A significant amount of experimental evidence suggests that G-protein coupled receptors (GPCRs) do not act exclusively as monomers but also form biologically relevant dimers and oligomers. However, the structural determinants, stoichiometry and functional importance of GPCR oligomerization remain topics of intense speculation. In this study we attempted to evaluate the nature and dynamics of GPCR oligomeric interactions. A representative set of GPCR homodimers were studied through Coarse-Grained Molecular Dynamics simulations, combined with interface analysis and concepts from network theory for the construction and analysis of dynamic structural networks. Our results highlight important structural determinants that seem to govern receptor dimer interactions. A conserved dynamic behavior was observed among different GPCRs, including receptors belonging in different GPCR classes. Specific GPCR regions were highlighted as the core of the interfaces. Finally, correlations of motion were observed between parts of the dimer interface and GPCR segments participating in ligand binding and receptor activation, suggesting the existence of mechanisms through which dimer formation may affect GPCR function. The results of this study can be used to drive experiments aimed at exploring GPCR oligomerization, as well as in the study of transmembrane protein-protein interactions in general.

  6. Some aspects of the structure and the diversity of the arboreal vegetation of a forest of origin alluvial, not inundating of the Amazons River

    International Nuclear Information System (INIS)

    Palacios, Pablo A

    2001-01-01

    For the unaware observer, the Amazonian it is a great green and homogeneous mat, sometimes interrupted by serpentine currents of water that they break the continuity of the vegetable mantel. A detailed observation dispels that impression of homogeneity of the Amazon forest. On the contrary the Hylea is sprinkled of overflowed ambient, with numerous plants of thin shafts that conform a tangle, alternate of environments of plane topography, of soils well drainages, trees of thicker trunks, or set of hills of marked slopes, with narrow or wide summits and trees of diverse size and grosser. Equally the Amazonian region has environments that don't correspond to properly this forest, located on tables of gritty white of thin and low vegetation. The author treats topics as general aspects of the Amazonian area, characterization of landscape and forest structures

  7. Structural aspects of materials hardening

    International Nuclear Information System (INIS)

    Naberenkov, A.V.; Fabritsiev, S.A.

    1996-01-01

    Dispersion-strengthened (DS) and precipitation-hardened (PH) copper-based alloys are suggested to be used for energy-strained components in the ITER discharge chambers. But, the stability of their properties remains still uncertain. It is evident, that of critical importance here is the stability of the composition and the morphology of disperse particles under irradiation. Also of importance is the coherent or noncoherent character of the impurity particle bonding with the lattice. In this work the impact of the size and density of fine inclusions into the matrix on the material yield strength for the DS alloys Cu-Mo and MAGT-0.2 was analyzed. The particle density is shown to be crucial in strengthening. At the same time the bonding of particles with the matrix is of minor importance. (orig.)

  8. Structural aspects and dielectric properties

    Indian Academy of Sciences (India)

    Unknown

    %), Sr(NO3)2 (Merck, 99%), TiO2. (Fluka, 99%), citric acid and ethylene glycol ... The resin turned to a black mass, which was ground to a powder in an agate mortar. This ground black mass is henceforth called a precursor. A white powder was ...

  9. Financial aspects of decommissioning (key aspects of decommissioning costing)

    International Nuclear Information System (INIS)

    Danska, V.

    2009-01-01

    In this presentation the following aspects of NPPs decommissioning are discussed: Requirements and purpose of decommissioning costing; Decommissioning costing methodologies; Standardised decommissioning cost structure; Input data for cost estimate process; Waste management in cost estimate process; Grading aspects in cost estimating; Cost control in decommissioning projects; Summary of the cost estimation process; Conclusions and recommendations.

  10. Developmental aspects of English argument structure constructions for Korean-speaking second language learners: Usage-based constructional approaches to language development

    Directory of Open Access Journals (Sweden)

    Gyu-Ho Shin

    2017-01-01

    Full Text Available This study investigates developmental aspects of English Argument Structure Constructions (ASCs for Korean-speaking second language (L2 learners, providing evidence of how they manifest human domain-general cognitive systems during language acquisition via usage-based constructional approaches to language development. Participants were instructed on six English ASC types with their representative verbs for three months. The data from grammaticality preference tasks, writing tests, and free-writing tasks were analysed. Comprehension data from the grammaticality preference tasks showed significant improvement in understanding ASCs after instruction, supporting sentence-level generalisations for language comprehension independent of individual verbs. The production data from the writing tests demonstrated more frequent use of two-argument constructions than three-argument ones, which indicates the internal complexity between ASC types. The results of the writing tests also displayed skewed exploitation of verbs representative of the target ASCs, implying a frequency-sensitive nature of language acquisition. All production data further revealed active use of prefabricated chunks and incorporation of new and old language items. Taken all together, these observations suggest language learners’ merging narrowly stabilised L2 routines with other (non-linguistic resources as necessary, sustaining efficiency in a sentence-building process, under the superintendence of cognitive factors when satisfying communicative intents.

  11. Does gender moderate the subjective measurement and structural paths in behavioural and cognitive aspects of gambling disorder in treatment-seeking adults?

    Science.gov (United States)

    Smith, David; Battersby, Malcolm; Harvey, Peter

    2015-09-01

    Gender differences have been observed in the pathogenesis of gambling disorder and gambling related urge and cognitions are predictive of relapse to problem gambling. A better understanding of these mechanisms concurrently may help in the development of more directed therapies. We evaluated gender effects on behavioural and cognitive paths to gambling disorder from self-report data. Participants (N=454) were treatment-seeking problem gamblers on first presentation to a gambling therapy service between January 2012 and December 2014. We firstly investigated if aspects of gambling related urge, cognitions (interpretive bias and gambling expectancies) and gambling severity were more central to men than women. Subsequently, a full structural equation model tested if gender moderated behavioural and cognitive paths to gambling severity. Men (n=280, mean age=37.4years, SD=11.4) were significantly younger than women (n=174, mean age=48.7years, SD=12.9) (pgambling severity, gambling related urge, interpretive bias and gambling expectancies. The paths for urge to gambling severity and interpretive bias to gambling severity were stronger for men than women and statistically significant (pgambling expectancies to gambling severity were insignificant for both men and women. This study detected an important signal in terms of theoretical mechanisms to explaining gambling disorder and gender differences. It has implications for treatment development including relapse prevention. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Medicinal Plants in the Broad-Leaf Mixed Coniferous Forest of Tshothang Chiwog, Bhutan: Floristic Attributes, Vegetation Structure, Ethnobotany, and Socioeconomic Aspects

    Directory of Open Access Journals (Sweden)

    Ngawang Jamba

    2018-01-01

    Full Text Available The Himalayan Kingdom of Bhutan, located in one of the global biodiversity hotspots, is endowed with abundant floral wealth, including a wide array of medicinal plants (MPs. However, over-exploitation of these resources is widespread, and only a few studies have assessed the richness and diversity of Bhutanese forests and in particular about the MP resources. A vegetation survey was conducted in Tshothang Chiwog, south-eastern Bhutan to characterize the floristic structure of the broad-leaf mixed coniferous forests with a special focus on MPs. A questionnaire survey involving 40 farmers was also conducted to assess the ethnobotanical and socioeconomic aspects of MP extraction. A total of 157 plant species (38 trees, 19 shrubs, 85 herbs and ferns, and 15 climbers, representing 74 families and 137 genera were identified from the study area, of which 69 species (14 trees, 10 shrubs, 38 herbs and ferns, and seven climbers, belonging to 41 families and 69 genera were medicinally important. The most species-rich families of medicinal plants were: Asteraceae (eight spp., Apiaceae (four spp., Polygonaceae, Brassicaceae, Zingiberaceae, and Urticaceae (three species each. Herbaceous flora exhibited the highest diversity (Simpson diversity index, D = 0.97 and Shannon-Weiner index, H′ = 5.82, followed by trees and shrubs (D = 0.95 and 0.92 and H′ = 4.86 and 3.97, respectively. All but one herb showed abundance-to-frequency ratio (A/F ≥0.05, signifying a contagious distribution pattern (large aggregated distribution. Girth class distribution of trees followed an inverse J-shaped pattern. Results of the ethnobotanic study documented 55 MPs. MP collection, as reported by the interviewees, generally improved the socioeconomic status of the people of Tshothang Chiwog. Apart from improving the livelihood security of the local people, aspects relating to health care and culture are also important. Respondents were also concerned about the declining MP wealth

  13. Nanowire assembly, e.g. for optical probes, comprises optically trapping high aspect ratio semiconductor nanowire with infrared single-beam optical trap and attaching nanowire to organic or inorganic structure

    OpenAIRE

    Pauzauskie, P.; Radenovic, A.; Trepagnier, E.; Liphardt, J.; Yang, P.

    2007-01-01

    NOVELTY - A nanowire assembly method comprises optically trapping a semiconductor nanowire with an infrared single-beam optical trap and attaching the nanowire to an organic or inorganic structure by laser fusing. The nanowire is further trapped in a fluid environment. The optical trap has a beam wavelength of 1064 nm. The nanowire has an aspect ratio greater than 100 and a diameter less than 100 (preferably less than 80) nm. The nanowire and the organic or inorganic structure form a heterost...

  14. Structural systematics of rare earth complexes. III. Structural characterization of lanthanoid (III) picrate hydrates: gadolinium picrate dodecahydrate - an x-ray-induced phase modifications? - and some general aspects of structural chemistry of lanthanoid picrates

    International Nuclear Information System (INIS)

    Harrowfield, J.M.; Weimin, Lu; Brian, W.S.; White, A.H.

    1994-01-01

    In the course of the previous studies (Parts I and II), an unusual result was observed in the case of the structure determination of hydrated gadolinium(III) picrate. Midway through data collection, the monoclinic P2 1 /c phase modification (X-ray-induced?) to a similar cell more nearly resembling that of the La→Pr structure type recorded previously, with no loss of crystal integrity, and with useful data sets being obtained on both forms. Redetermination of the structure with a fresh sample yielded no reproduction of the anomaly. These results are recorded and discussed, together with an overview of the consequences of the data of Parts I-III in relation to those of other literature in the field. 13 refs., 4 tabs., 1 fig

  15. Alocação de recursos (carboidratos no desenvolvimento inicial de plântulas de Schizolobium parahyba (Vell. S.F. Blake (Fabaceae - Caesalpinioideae Resource allocation (carbohydrates in the inicial development of seedlings of Schizolobium parahyba (Vell. S.F. Blacke (Fabaceae - Caesalpinioideae

    Directory of Open Access Journals (Sweden)

    Emanuela Wehmuth Alves Weidlich

    2010-08-01

    between biomass, total soluble sugar and starch have shown the mobilization of the store from cotyledons to the other structures of the plant while the reduction of biomass and sugars of cotyledons result in an increase of biomass in epicotyls, stems and roots of the seedling.

  16. Practical Aspects of CMOS Layout

    DEFF Research Database (Denmark)

    Stassen, Flemming

    1996-01-01

    The topics covered in these notes are the practical aspects and limitations of layout, when random process variations result in electrical parameters, which are not constant but rather statistically distributed.The focus is on design methods for reducing or eliminating the effects. The notes cover...... three aspects:1) to introduce layout structures robust to process variations2) to present simplistic models for analog building blocks with the aim of analysing consequences of parameter variations3) to present the basic noise considerations which guide the layout of supply structures etc....

  17. Analysis of the embodied energy and the CO2 emission in construction process of a bridge structure from the aspect of sustainability

    Directory of Open Access Journals (Sweden)

    Čokić Miloš

    2015-01-01

    Full Text Available This paper presents a comparative analysis of embodied energy and CO2 emission, in the construction process of three bridge structures. Analyzed structures are prestressed concrete bridges with different structural systems and a total length of 88 meters. The correlation of structural system, construction method, material quantities and embodied energy and CO2 emission were considered. Influence of the selected solutions in main steps of design and construction on the energy consumption and the emission of CO2 is presented. The results should provide a better understanding of the effects of certain factors, in the bridge construction process, and their impact on the environment.

  18. Aspects and Polymorphism in AspectJ

    DEFF Research Database (Denmark)

    Lorenz, David Harel; Ernst, Erik

    2003-01-01

    There are two important points of view on inclusion or subtype polymorphism in object-oriented programs, namely polymorphic access and dynamic dispatch. These features are essential for object-oriented programming, and it is worthwhile to consider whether they are supported in aspect......-oriented programming (AOP). In AOP, pieces of crosscutting behavior are extracted from the base code and localized in aspects, losing as a result their polymorphic capabilities while introducing new and unexplored issues. In this paper, we explore what kinds of polymorphism AOP languages should support, using Aspect......J as the basis for the presentation. The results are not exclusive to AspectJ---aspectual polymorphism may make aspects in any comparable AOSD language more expressive and reusable across programs, while preserving safety....

  19. An investigation on the structure, spectroscopy and thermodynamic aspects of Br2((-))(H2O)n clusters using a conjunction of stochastic and quantum chemical methods.

    Science.gov (United States)

    Naskar, Pulak; Chaudhury, Pinaki

    2016-06-28

    In this work we obtained global as well as local structures of Br2((-))(H2O)n clusters for n = 2 to 6 followed by the study of IR-spectral features and thermochemistry for the structures. The way adopted by us to obtain structures is not the conventional one used in most cases. Here we at first generated excellent quality pre-optimized structures by exploring the suitable empirical potential energy surface using stochastic optimizer simulated annealing. These structures are then further refined using quantum chemical calculations to obtain the final structures, and spectral and thermodynamic features. We clearly showed that our approach results in very quick and better convergence which reduces the computational cost and obviously using the strategy we are able to get one [i.e. global] or more than one [i.e. global and local(s)] energetically lower structures than those which are already reported for a given cluster size. Moreover, IR-spectral results and the evolutionary trends in interaction energy, solvation energy and vertical detachment energy for global structures of each size have also been presented to establish the utility of the procedure employed.

  20. Nuclear muon capture - theoretical aspects

    International Nuclear Information System (INIS)

    Mukhopadhyay, N.C.

    1978-01-01

    Nuclear muon capture processes are considered with especial reference to particle physics interests and the possibility of probing aspects of nuclear structure such as nuclear symmetries, cluster correlations and giant resonance excitations. The question of the adequacy of the free muon-nucleon weak interaction inputs in an impulse approximation treatment of the muon capture by complex nuclei is examined. (U.K.)

  1. Structural and physical aspects of room temperature oxidized La2-xSrxCuO4+y (O-LESS-THAN-X-LESS-THAN-0.15)

    DEFF Research Database (Denmark)

    Rial, C.; Amador, U.; Moran, E.

    1994-01-01

    Crystal structure, oxygen stoichiometries and superconducting properties of RT chemically oxidized La2-xSrxCuO4+y (0 analysis and magnetic susceptibility measurements. The presence of interstitial oxygen located...

  2. Aspects on Aspect : Theory and Applications of Grammatical Aspect in Spanish

    NARCIS (Netherlands)

    González González, P.

    2003-01-01

    This thesis provides an overview of disciplines related to the grammatical phenomenon of aspect. There are several claims advocated in this thesis, according to the different disciplines dealt with in each chapter. Chapter 1 claims that intra-sentential semantic structure contains three potential

  3. New insights into structural and stratigraphic aspects of central Northern Switzerland from the Nagra 2D reflection seismic campaign 2011/12

    Energy Technology Data Exchange (ETDEWEB)

    Meier, B. [Proseis AG, Zürich (Switzerland)

    2015-07-01

    In this article, some findings resulting from the interpretation of reprocessed and newly acquired 2D seismic data in the central Northern Switzerland are presented. The seismic examples illustrate the relationship between basement and cover-tectonics and offer a closer look at seismic-stratigraphic characteristics which can be observed in the Middle Jurassic sequence. The new 2D seismic data have closed an important data gaps between the Nagra siting regions 'Jura Ost' and Nördlich Lägern' proposed for radioactive waste disposal and allow clarification of the general structural framework and internal composition of the Permo-Carboniferous Through. Furthermore, the kinematic relationships between the basement and cover structures can be studied and the newly acquired seismic data have allowed detailed depositional structures and seismic facies changes within the Mid-Upper Dogger sequence to be recognized, particularly east and west of the lower Aare valley. (author)

  4. Discovering Early Aspects

    NARCIS (Netherlands)

    Baniassad, E.; Clements, P.; Araujo, J.; Moreira, A; Rashid, A.; Tekinerdogan, B.

    2006-01-01

    Traditionally, aspect-oriented software development (AOSD) has focused on the software life cycle's implementation phase: aspects are identified and captured mainly in code. But aspects are evident earlier in the life cycle, such as during requirements gathering and architecture development.

  5. Structural aspects of crotalic venom proteins modified by ionizing radiation; Aspectos estruturais de proteinas do veneno crotalico modificadas por radiacao ionizante

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Karina Corleto de

    2010-07-01

    Snake bites are a serious public health problem, especially in subtropical countries. In Brazil, the Ministry of Health notified around 26 000 accidents in 2008. The genus Crotalus (rattlesnakes) accounts for approximately 7% of the total, with a high mortality rate of 72% when untreated with the specific serum, the only effective treatment in case of snake bites. In Brazil, the serum is produced in horses which, despite the large size, have a reduced lifespan due to the high toxicity of the antigen. Ionizing radiation has proven to be an excellent tool for reducing the toxicity of venoms and isolated toxins, resulting in better immunogens for serum production, and contributing to the welfare of serum producing animals. Since the action of gamma radiation on venoms and toxins has not been yet fully clarified from the structural point of view, we proposed in this paper, to characterize two toxins of the species Crotalus durissus terrificus: crotoxin and crotamine. After isolation of the toxins of interest by chromatographic techniques, they were subjected to structural analysis with the application of the following methods: Fluorescence, Circular Dichroism, Differential Calorimetry and Infrared Spectroscopy. These tests showed that both crotamine as crotoxin when subjected to gamma radiation, showed changes in their structural conformation compared with the samples in the native state. Such changes probably occur in the secondary and tertiary structure and may explain the changes on the biological activity of these toxins. (author)

  6. Structural aspects of B2O3-substituted (PbO)0.5(SiO2)0.5 glasses

    International Nuclear Information System (INIS)

    Sudarsan, V.; Kulshreshtha, S.K.; Shrikhande, V.K.; Kothiyal, G.P.

    2002-01-01

    Lead borosilicate glasses having general formulae (PbO) 0.5-x (SiO 2 ) 0.5 (B 2 O 3 ) x with 0.0≤x≤0.4 and (PbO) 0.5 (SiO 2 ) 0.5-y (B 2 O 3 ) y with 0.0≤y≤0.5 have been prepared by a conventional melt-quench method and characterized by 29 Si, 11 B magic angle spinning (MAS) NMR techniques and infrared spectroscopy, as regards their structural features. From 29 Si NMR results, it has been inferred that with increasing concentration of boron oxide, (PbO) 0.5-x (SiO 2 ) 0.5 (B 2 O 3 )x glasses exhibit a systematic increase in the number of Q 4 structural units of Si at the expense of Q 2 structural units, along with the formation of Si-O-B linkages. On the other hand, for (PbO) 0.5 (SiO 2 ) 0.5-y (B 2 O 3 ) y glasses, there is no direct interaction between SiO 2 and B 2 O 3 in the glass network, as revealed by the 29 Si MAS NMR studies. Boron exists in both trigonal and tetrahedral configurations for these two series of glasses and for the (PbO) 0.5 (SiO 2 ) 0.5-y (B 2 O 3 ) y series of glasses; the relative concentration of these two structural units remains almost constant with increasing B 2 O 3 concentration. In contrast, for (PbO) 0.5-x (SiO 2 ) 0.5 (B 2 O 3 ) x glasses, there is a slight increase in the number of BO 3 structural units above x = 0.2, as there is a competition between SiO 2 and B 2 O 3 for interaction with Pb 2+ , thereby leading to the formation of BO 3 structural units. For both series of glasses, the thermal expansion coefficient is found to decrease with increasing B 2 O 3 concentration, the effect being more pronounced for the (PbO) 0.5-x (SiO 2 ) 0.5 (B 2 O 3 ) x series of glasses due to the increased concentration of Q 4 structural units of silicon and better cross-linking as a result of the formation of Si-O-B-type linkages. (author)

  7. Macropolyhedral boron-containing cluster chemistry. Aspects of the S2B16H16 system. Preparation, structure, NMR spectroscopy and isomerism

    Czech Academy of Sciences Publication Activity Database

    Dosangh, P. K.; Bould, J.; Londesborough, Michael Geoffrey Stephen; Jelínek, Tomáš; Thornton-Pett, M.; Štíbr, Bohumil; Kennedy, J. D.

    2003-01-01

    Roč. 680, 1-2 (2003), s. 312-322 ISSN 0022-328X R&D Projects: GA MŠk LN00A028; GA MŠk LB98233 Institutional research plan: CEZ:AV0Z4032918 Keywords : heteroborane cluster isomerism * marcopolyhedral thiaborane * X-ray structures Subject RIV: CA - Inorganic Chemistry Impact factor: 2.042, year: 2003

  8. International Workshop on Structural and Functional Aspects of the Cholinergic Synapse Held in Jerusalem, Isreal on 30 August-4 September 1987

    Science.gov (United States)

    1987-09-01

    in the sinaptic clefts of motor endplates, to the neuronal synapses of caudate nucleus and sympathetic ganglia, where the accumulation of AChE is much...70,000 Da protein. Supported by the Muscular Dystrophy Association, New York, N.Y. and the Israel Academy of Sciences. Basic Research Division. - 55...markers,ihich determine the genetic type of the brain structures (one for all) and to forming of the inborn (uncnditional) reflexes . The genetically

  9. The Participation of Girls and Boys from Ages 10 to 18 in Structured Sports and Extra-Curricular Activities in the Aspect of Social and Economic Conditions

    Directory of Open Access Journals (Sweden)

    Dmitruk Agnieszka

    2015-03-01

    Full Text Available Introduction. The importance of socio-economic factors in differentiating the physical activities of children and teenagers keeps changing. That is why the goal of this research was to identify certain social variables amongst those listed most often which differentiate the level of targeted physical activity of urban children and youths from the Bialskie district. Material and methods. The research was conducted on 1.084 students between the ages of 10 and 18. Three age groups were chosen: 10 to 12, 13 to 15, and 16 to 18. Information about the attendance of respondents in Physical Education classes and structured extra-curricular sport activities, as well as preferred forms of physical activities were collected via a diagnostic survey. The same method was used in the assessment of the socio-economic status of the families of the respondents. The relations between attendance in extra-curricular sports activities and socio-economic factors was assessed by a multifactoral logistic regression model, and the statistical relevance of the differences was calculated by the Wald test. Results. Attendance in structured extra-curricular physical activity depended mostly on income per family member. In the case of type of work performed by parents, the attendance rate in both boys and girls was higher if the parents performed intellectual work. Parents' education and number of children in the family did not have a high influence on the attendance of respondents in structured extra-curricular sport activities. Conclusions. Increasing disproportions in societal prosperity can be an important factor limiting the attendance of the poorest group of children and youths in structured physical activities. The lack of influence on physical activity of such socio-economic variables as parents' education and the number of children in the family can be connected with the change of meaning of those factors in modern society (depreciation of the importance of higher

  10. Some aspects of hydrogen plasma treatment of anti-modulation doped near surface GaAs/AlGaAs single quantum well structures

    International Nuclear Information System (INIS)

    Bumai, Yu.A.; Gobsch, G.; Goldhahn, R.; Stein, N.; Golombek, A.; Nakov, V.; Cheng, T.S.

    1999-01-01

    The MBE grown anti-modulation doped GaAs/AlGaAs structures with near surface single quantum wells were exposed to a DC hydrogen plasma (∼400 eV) and investigated using PL, PLE and PR spectroscopy at 5 K. Strong acceptor related free to bound transition (FB) dominates for quantum well related PL but excitonic features are still observed in PLE spectra. After hydrogen plasma treatment the PL intensity of FB transition from quantum well was strongly increased for above AlGaAs band gap excitation and was unchanged for below AlGaAs one. These results are consistent with atomic hydrogen passivation of deep defects in AlGaAs barriers. At the same time radiative excitonic recombination was quenched by hydrogenation. PLE and PR spectra indicate on a strong increase of electric field in subsurface region of the structure after hydrogenation. The increase of electric field in anti-modulation doped structure after hydrogen plasma treatment is supposed to be due to passivation by atomic hydrogen of surface states that leads to unpinning of Fermi level from mid gap to carbon acceptor level position in GaAs cap layer. It causes the further band bending and surface electric field increase that strongly suppress excitonic recombination in near surface quantum wells

  11. Structure/functional aspects of the human riboflavin transporter-3 (SLC52A3): role of the predicted glycosylation and substrate-interacting sites.

    Science.gov (United States)

    Subramanian, Veedamali S; Sabui, Subrata; Teafatiller, Trevor; Bohl, Jennifer A; Said, Hamid M

    2017-08-01

    The human riboflavin (RF) transporter-3 (hRFVT-3; product of the SLC52A3 gene) plays an essential role in the intestinal RF absorption process and is expressed exclusively at the apical membrane domain of polarized enterocytes. Previous studies have characterized different physiological/biological aspects of this transporter, but nothing is known about the glycosylation status of the hRFVT-3 protein and role of this modification in its physiology/biology. Additionally, little is known about the residues in the hRFVT-3 protein that interact with the ligand, RF. We addressed these issues using appropriate biochemical/molecular approaches, a protein-docking model, and established intestinal/renal epithelial cells. Our results showed that the hRFVT-3 protein is glycosylated and that glycosylation is important for its function. Mutating the predicted N -glycosylation sites at Asn 94 and Asn 168 led to a significant decrease in RF uptake; it also led to a marked intracellular (in the endoplasmic reticulum, ER) retention of the mutated proteins as shown by live-cell confocal imaging studies. The protein-docking model used in this study has identified a number of putative substrate-interacting sites: Ser 16 , Ile 20 , Trp 24 , Phe 142 , Thr 314 , and Asn 315 Mutating these potential interacting sites was indeed found to lead to a significant inhibition in RF uptake and to intracellular (ER) retention of the mutated proteins (except for the Phe 142 mutant). These results demonstrate that the hRFVT-3 protein is glycosylated and this glycosylation is important for its function and cell surface expression. This study also identified a number of residues in the hRFVT-3 polypeptide that are important for its function/cell surface expression.

  12. New approaches for the reliability-oriented structural optimization considering time-variant aspects; Neue Ansaetze fuer die zuverlaessigkeitsorientierte Strukturoptimierung unter Beachtung zeitvarianter Aspekte

    Energy Technology Data Exchange (ETDEWEB)

    Kuschel, N.

    2000-07-01

    The optimization of structures with respect to cost, weight or performance is a well-known application of the nonlinear optimization. However reliability-based structural optimization has been subject of only very few studies. The approaches suggested up to now have been unsatisfactory regarding general possibility of application or easy handling by user. The objective of this thesis is the development of general approaches to solve both optimization problems, the minimization of cost with respect to constraint reliabilty and the maximization of reliability under cost constraint. The extented approach of an one-level-method will be introduced in detail for the time-invariant problems. Here, the reliability of the sturcture will be analysed in the framework of the First-Order-Reliability-Method (FORM). The use of time-variant reliability analysis is necessary for a realistic modelling of many practical problems. Therefore several generalizations of the new approaches will be derived for the time-variant reliability-based structural optimization. Some important properties of the optimization problems are proved. In addition some interesting extensions of the one-level-method, for example the cost optimization of structural series systems and the cost optimization in the frame of the Second-Order-Reliabiity-Method (SORM), are presented in the thesis. (orig.) [German] Die Optimierung von Tragwerken im Hinblick auf die Kosten, das Gewicht oder die Gestalt ist eine sehr bekannte Anwendung der nichtlinearen Optimierung. Die zuverlaessigkeitsorientierte Strukturoptimierung wurde dagegen weit seltener untersucht. Die bisher vorgeschlagenen Ansaetze koennen bezueglich ihrer allgemeinen Verwendbarkeit oder ihrer nutzerfreundlichen Handhabung nicht befriedigen. Das Ziel der vorliegenden Arbeit ist nun die Entwicklung allgemeiner Ansaetze zur Loesung der beiden Optimierungsprobleme, einer Kostenminimierung unter Zuverlaessigkeitsrestriktionen und einer

  13. Structural aspects of displacive transformations: what can optical microscopy contribute? Dehydration of Sm2(C2O43·10H2O as a case study

    Directory of Open Access Journals (Sweden)

    Alexander A. Matvienko

    2017-09-01

    Full Text Available For martensitic transformations the macroscopic crystal strain is directly related to the corresponding structural rearrangement at the microscopic level. In situ optical microscopy observations of the interface migration and the change in crystal shape during a displacive single crystal to single crystal transformation can contribute significantly to understanding the mechanism of the process at the atomic scale. This is illustrated for the dehydration of samarium oxalate decahydrate in a study combining optical microscopy and single-crystal X-ray diffraction.

  14. Local structural aspects of the metal-insulator transition in CuIr2S4 from total scattering x-ray study

    Science.gov (United States)

    Bozin, E.; Masadeh, A. S.; Kim, H. J.; Juhas, P.; Billinge, S. J. L.; Mitchell, J. F.

    2008-03-01

    A thiospinel CuIr2S4 exhibits a metal-insulator (MI) transition at T=230 K, with simultaneous spin-dimerization and charge-ordering [1]. The transition can also be driven by extended exposure to the x-rays at low T [2, 3]. Total x-ray scattering study of CuIr2S4 was carried out using 100 KeV synchrotron beam and rapid acquisition pair distribution function (RAPDF) approach. The RAPDF results indicate consistency of the local and average structure at high T. At 100 K long x-ray exposure melts the long-range order (LRO) of the dimerization pattern, without affecting the local structure, in agreement with diffuse scattering result [3]. The dependence of the LRO related superlattice peak intensity on the exposure time reveals that the melting occurs within approximately 15 seconds of exposure under experimental conditions used. At 100 K the LRO is recovered without temperature increase quickly after the cessation of the beamtime exposure. Results on Cr doped samples will be addressed as well. [1] P.G. Radaelli et al., Nature 416, 155 (2002). [2] V. Kiryukhin et al., Phys. Rev. Lett. 97, 225503 (2006). [3] H. Ishibashi et al., Phys. Rev. B 66, 144424 (2002). This work is supported by the NSF under grant DMR-0304391. ANL is supported under DOE contract No. DE-AC02-06CH11357.

  15. Linear signal hyperintensity adjacent to the subchondral bone plate at the knee on T2-weighted fat-saturated sequences: imaging aspects and association with structural lesions

    International Nuclear Information System (INIS)

    Gondim Teixeira, Pedro Augusto; Balaj, Clemence; Marie, Beatrice; Lecocq, Sophie; Louis, Matthias; Blum, Alain; Braun, Marc

    2014-01-01

    To describe the association between linear T2 signal abnormalities in the subchondral bone and structural knee lesions. MR studies of patients referred for the evaluation of knee pain were retrospectively evaluated and 133 of these patients presented bone marrow edema pattern (BMEP) (study group) and while 61 did not (control group). The presence of linear anomalies of the subchondral bone on T2-weighted fat-saturated sequences was evaluated. The findings were correlated to the presence of structural knee lesions and to the duration of the patient's symptoms. Histologic analysis of a cadaveric specimen was used for anatomic correlation. Linear T2 hyperintensities at the subchondral bone were present in 41 % of patients with BMEP. None of the patients in the control group presented this sign. When a subchondral linear hyperintensity was present, the prevalence of radial or root tears was high and that of horizontal tears was low (71.4 and 4.8 %, respectively). Sixty-nine percent of the patients with a subchondral insufficiency fracture presented a subchondral linear hyperintensity. It was significantly more prevalent in patients with acute or sub-acute symptoms (p < 0.0001). The studied linear T2 hyperintensity is located at the subchondral spongiosa and can be secondary to local or distant joint injuries. Its presence should evoke acute and sub-acute knee injuries. This sign is closely related to subchondral insufficiency fractures and meniscal tears with a compromise in meniscal function. (orig.)

  16. Linear signal hyperintensity adjacent to the subchondral bone plate at the knee on T2-weighted fat-saturated sequences: imaging aspects and association with structural lesions

    Energy Technology Data Exchange (ETDEWEB)

    Gondim Teixeira, Pedro Augusto; Balaj, Clemence [CHU Hopital Central, Service D' Imagerie Guilloz, Nancy (France); Universite de Lorraine, IADI, UMR S 947, Nancy (France); Marie, Beatrice [CHU Hopital Central, Service d' Anatomo-Pathologie, Nancy (France); Lecocq, Sophie; Louis, Matthias; Blum, Alain [CHU Hopital Central, Service D' Imagerie Guilloz, Nancy (France); Braun, Marc [CHU Hopital Central, Service de Neuroradiologie, Nancy (France)

    2014-11-15

    To describe the association between linear T2 signal abnormalities in the subchondral bone and structural knee lesions. MR studies of patients referred for the evaluation of knee pain were retrospectively evaluated and 133 of these patients presented bone marrow edema pattern (BMEP) (study group) and while 61 did not (control group). The presence of linear anomalies of the subchondral bone on T2-weighted fat-saturated sequences was evaluated. The findings were correlated to the presence of structural knee lesions and to the duration of the patient's symptoms. Histologic analysis of a cadaveric specimen was used for anatomic correlation. Linear T2 hyperintensities at the subchondral bone were present in 41 % of patients with BMEP. None of the patients in the control group presented this sign. When a subchondral linear hyperintensity was present, the prevalence of radial or root tears was high and that of horizontal tears was low (71.4 and 4.8 %, respectively). Sixty-nine percent of the patients with a subchondral insufficiency fracture presented a subchondral linear hyperintensity. It was significantly more prevalent in patients with acute or sub-acute symptoms (p < 0.0001). The studied linear T2 hyperintensity is located at the subchondral spongiosa and can be secondary to local or distant joint injuries. Its presence should evoke acute and sub-acute knee injuries. This sign is closely related to subchondral insufficiency fractures and meniscal tears with a compromise in meniscal function. (orig.)

  17. The ethical aspects of mass communication

    OpenAIRE

    Наталья Ивановна Клушина

    2014-01-01

    This article focuses on the ethical aspects of mass communication and key trends of russian media language. The author analyses ethics and law in modern journalism, culture of speech in media discourse, intentional, structural and social aspects of mass communication. Ethics of mass communication presupposes the observance of legal and moral norms, social responsibility and respect for the audience.

  18. The ethical aspects of mass communication

    Directory of Open Access Journals (Sweden)

    Наталья Ивановна Клушина

    2014-12-01

    Full Text Available This article focuses on the ethical aspects of mass communication and key trends of russian media language. The author analyses ethics and law in modern journalism, culture of speech in media discourse, intentional, structural and social aspects of mass communication. Ethics of mass communication presupposes the observance of legal and moral norms, social responsibility and respect for the audience.

  19. Towards a better understanding of the geometrical and orientational aspects of the electronic structure of halogens (F–I) adsorption on graphene

    International Nuclear Information System (INIS)

    Widjaja, Hantarto; Jiang, Zhong-Tao; Altarawneh, Mohammednoor; Yin, Chun-Yang; Goh, Bee-Min; Mondinos, Nicholas; Dlugogorski, Bogdan Z.

    2015-01-01

    Graphical abstract: - Highlights: • Examines the orientation (zigzag, armchair) effects of F/Cl/Br/I-adsorbed graphene. • F cases are site-dependent, while Cl/Br/I cases have minimal orientation dependence. • F is adsorbed to graphene at about three times stronger than Cl/Br/I. • To prompt re-examination of elemental-graphene systems to account for orientation. - Abstract: Adding impurities or doping through adsorption is an effective way to modify the properties of graphene-based materials. The capability of making predictions pertinent to the trends of elemental adsorption on graphene is very instrumental towards a better understanding of the more complex adsorption cases. It also affords useful guidelines for fabricating 2-D graphene materials with novel properties. The electronic structure of elemental adsorption on graphene is affected by side of adsorption (single- or double-sided), site of adsorption (i.e. bridge, hollow or top), and the relative orientation of the adsorbed sites (i.e. zigzag or armchair). In this contribution, we apply density functional theory (DFT) calculations to investigate the electronic structures of halogens (F, Cl, Br, I) adsorbed on graphene at lower concentrations spanning 1:6, 1:8 and 1:18 atomic ratios, in order to elucidate effects of adsorption trends. We demonstrate that adsorption of F is merely site-dependent (top). On the contrary, adsorptions of Cl, Br and I display a minimal dependence towards orientation (i.e. the effects of the deployed supercells). Our findings provide a deeper understanding of the elemental adsorption on graphene in terms of geometry which may aid in reexamining previous studies and producing better predictions for future studies, in which the inclusion of orientation is indispensable.

  20. Chemical and mineralogical aspects of clay-salt slimes of 'Belaruskali' using for the preparation of nano-structured sorbents of radionuclides

    Energy Technology Data Exchange (ETDEWEB)

    Maskalchuk, L.; Baklay, A.; Leontieva, T. [Joint Institute for Power and Nuclear Research - Sosny, NAS of Belarus, Minsk, P.O.Box 119, 220109 (Belarus)

    2016-07-01

    n the context of intensive nuclear-power engineering development there is an urgent need to solve a range of technological and environmental challenges associated with generation, treatment and disposal of radioactive waste. In this regards, the problems of radioactive waste safe management and rehabilitation of radioactively contaminated soils in the result of the radiation accidents at the Chernobyl and Fukushima Daiichi NPPs are especially significant. Concerning that, investigation of effective and low cost sorption materials for radionuclides immobilization has a special relevance. In order to solve the above mentioned problems, it is supposed to develop a resource-saving technology for production of multi-purpose nano-structured sorbents of radionuclides ({sup 137}Cs, {sup 90}Sr) with predetermined physicochemical properties based on the waste of potash industry - clay-salt slimes (CSS) of the JSC 'Belaruskali'. The performed research has shown that the CSS samples have a high fixing ability in relation to {sup 137}Cs. The main sorption-active minerals in CSS are illite and montmorillonite. The degree of sorption is 99.6%, K{sub d} is 1.2*10{sup 5} l/kg, RIP(K) is 6343 mmol/kg. The modification of the S-1 sample allows to enlarge the content of sorption-active minerals tentatively in 3.5 times, thereafter RIP(K) for the S-3 sample may be significantly increased. Based on the obtained experimental data, CSS of the JSC 'Belaruskali' can be estimated as a perspective initial material for production of multi-purpose nano-structured sorbents of radionuclides. (authors)

  1. Relating structural aspects of bimetallic Pt(3)Cr(1)/C nanoparticles to their electrocatalytic activity, stability, and selectivity in the oxygen reduction reaction.

    Science.gov (United States)

    Taufany, Fadlilatul; Pan, Chun-Jern; Chou, Hung-Lung; Rick, John; Chen, Yong-Siou; Liu, Din-Goa; Lee, Jyh-Fu; Tang, Mau-Tsu; Hwang, Bing-Joe

    2011-09-12

    Two methods were used to prepare bimetallic Pt(3)Cr(1)/C nanocatalysts with similar composition but different alloying extent (structure). We investigated how these differences in alloying extent affect the catalytic activity, stability and selectivity in the oxygen reduction reaction (ORR). One method, based on slow thermal decomposition of the Cr precursor at a rate that matches that of chemical reduction of the Pt precursor, allows fine control of the composition of the Pt(3)Cr(1)/C alloy, whereas the second approach, using the ethylene glycol method, results in considerable deviation (>25 %) from the projected composition. Consequently, these two methods lead to variations in the alloying extent that strongly influence the Pt d-band vacancy and the Pt electroactive surface area (Pt ESCA). This relationship was systematically evaluated by transmission electron microscopy, X-ray absorption near edge structure spectroscopy, and electrochemical analysis. The ORR activity depends on two effects that nullify each other, namely, the number of active Pt sites and their activity. The Pt-site activity is more dominant in governing the ORR activity. The selectivity of the nanocatalyst towards the ORR and the competitive methanol oxidation reaction (MOR) depend on these two effects acting in cooperation to give enhanced ORR activity with suppressed MOR. The number of active Pt sites is associated with the Pt ESCA value, while Pt-site activity is associated with the alloying extent and Pt d-band vacancy (electronic) effects. The presence of Cr atoms in Pt(3)Cr(1)/C enhances stability during electrochemical treatment. Overall, the Pt(3)Cr(1)/C catalyst prepared by controlled-composition synthesis was shown to be superior in ORR activity, selectivity and stability owing to its favorable alloying extent, Pt d-band vacancy, and Pt ESCA. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Prospective study on the dose distribution to the acoustic structures during postoperative 3D conformal radiotherapy for parotid tumors. Dosimetric and audiometric aspects

    International Nuclear Information System (INIS)

    Jereczek-Fossa, Barbara A.

    2011-01-01

    To analyze dose distribution in the hearing organ and to evaluate the dose effect on the hearing thresholds in patients treated with post-parotidectomy 3-dimensional conformal radiotherapy (3D-CRT). A total of 17 patients received post-parotidectomy 3D-CRT (median dose: 63 Gy). The audiometric evaluation comprised pure tone audiometry and tympanometry performed before radiotherapy (RT) and 3, 6, and 24 months after RT. The ear structures were delineated on planning computer tomography scans. Mean and maximum doses were calculated and dose-volume histograms were plotted. Before RT, the median baseline audiometric thresholds were normal. At 3 months post-RT, 3 patients were diagnosed as having middle ear underpressure and/or effusion that resolved completely by 6 months. During 2-year follow-up, none of the ears showed perceptive hearing loss at speech frequencies. The mean doses at ipsilateral external auditory canal, mastoids cells, tympanic case, Eustachian tube, semicircular canals, and cochlea were 44.8 Gy, 39.0 Gy, 30.9 Gy, 33.0 Gy, 19.6 Gy, and 19.2 Gy, respectively. The doses to the contralateral ear were negligible, except for the Eustachian tube (up to 28.2 Gy). Post-parotidectomy 3D-CRT is associated with relatively low doses to the ear and the surrounding structures. Post-RT audiometry did not show any permanent (neither conductive nor perceptive) hearing impairment. Only in 3 patients were there signs of transient unilateral dysfunction of the Eustachian tube observed during the first few months after RT. Longer follow-up and larger patient series are warranted to confirm these preliminary findings. (orig.)

  3. AspectKE*

    DEFF Research Database (Denmark)

    Yang, Fan; Masuhara, Hidehiko; Aotani, Tomoyuki

    2010-01-01

    mechanism for pointcuts, so that pointcuts can uniformly specify join points based on both static and dynamic information about the program. Our implementation strategy performs fundamental static analysis at load-time, so as to retain runtime overheads minimal. We implemented a compiler for Aspect......Enforcing security policies to distributed systems is difficult, in particular, when a system contains untrusted components. We designed AspectKE*, a distributed AOP language based on a tuple space, to tackle this issue. In AspectKE*, aspects can enforce access control policies that depend...... on future behavior of running processes. One of the key language features is the predicates and functions that extract results of static program analysis, which are useful for defining security aspects that have to know about future behavior of a program. AspectKE* also provides a novel variable binding...

  4. Gestational surrogacy: Psychosocial aspects

    Directory of Open Access Journals (Sweden)

    Nicolás Ruiz-Robledillo

    2016-12-01

    Full Text Available Innovation in assisted reproductive technologies together with increased infertility and new family structures are increasing the use of gestational surrogacy as a means to have children. Before, during and after the process, it is necessary to study the psychosocial characteristics of triad members: the gestational surrogate, intended parents, and offspring. Research has indicated positive adaptation to the process and benefits for all members of the triad. Altruism is the main motivation of surrogates. Notably, psychological well-being has been found to be higher in individuals who have become parents through surrogacy than in those who have used egg donation or have followed a natural process of conception. Moreover, no differences in psychosocial characteristics have been observed in the offspring, compared with children born through natural conception or egg donation. Results highlight the positive aspects of surrogacy. Future research should investigate psychosocial factors that modulate the process, acting as risk and protective factors for well-being of the triad members, and identify the optimal profiles of surrogates for the process to be a success.

  5. Cultural aspects of suicide.

    Science.gov (United States)

    Maharajh, Hari D; Abdool, Petal S

    2005-09-08

    Undefined cultural factors cannot be dismissed and significantly contribute to the worldwide incidence of death by suicide. Culture is an all embracing term and defines the relationship of an individual to his environment. This study seeks to investigate the effect of culture on suicide both regionally and internationally. Culture-bound syndrome with suicidal behaviours specific to a particular culture or geographical region are discussed. Opinions are divided as to the status of religious martyrs. The law itself is silent on many aspects of suicidal behaviour and despite decriminalization of suicide as self-murder, the latter remains on the statutes of many developing countries. The Caribbean region is of concern due to its steady rise in mean suicide rate, especially in Trinidad and Tobago where socio-cultural factors are instrumental in influencing suicidal behaviour. These include transgenerational cultural conflicts, psycho-social problems, media exposure, unemployment, social distress, religion and family structure. The methods used are attributed to accessibility and lethality. Ingestion of poisonous substances is most popular followed by hanging. The gender differences seen with regard to suicidality can also be attributed to gender related psychopathology and psychosocial differences in help-seeking behaviour. These are influenced by the cultural environment to which the individual is exposed. Culture provides coping strategies to individuals; as civilization advances many of these coping mechanisms are lost unclothing the genetic predisposition of vulnerable groups. In the management of suicidal behaviour, a system of therapeutic re-culturation is needed with an emphasis on relevant culture- based therapies.

  6. Effects of {sup 137}Cs and {sup 90}Sr on structure and functional aspects of the microflora in agricultural used soils

    Energy Technology Data Exchange (ETDEWEB)

    Niedree, Bastian

    2013-11-01

    At long sight {sup 137}Cs and {sup 90}Sr are the main radionuclides responsible for the contamination of agricultural soils due to core melts in nuclear power plants such as Chernobyl or Fukushima. Once deposited on the soil surface, the two radionuclides remain in the upper soil layer for several decades. In the upper soil layer the highest microbial activity can be found, due to high organic matter contents, warm temperatures and gas exchange with the atmosphere. Hence, in contaminated soils microorganisms in upper soil layers (e.g. the plow layer on agricultural fields) are exceedingly exposed to radioactivity. However, no data are available how radioactive contaminations with {sup 137}Cs or {sup 90}Sr in a realistic order of magnitude affect the microbial community and its functions in soils. This dissertation discusses the effects of radioactive contaminations on the microbial community structure and some of its functions in soils. Therefore, typical agricultural soils, an Orthic Luvisol from field site Merzenhausen and a Gleyic Cambisol from field site Kaldenkirchen-Huelst were artificially contaminated with various concentrations of {sup 137}Cs and {sup 90}Sr and partly applied with radiolabeled substrates and incubated in soil microcosms under controlled laboratory conditions. The lower radionuclide concentrations corresponded to the contaminations in the Chernobyl exclusion zone, the higher concentrations were up to 50-fold that of the maximum occurring hotspots ({sup 137}Cs) in this zone. In three experiments the effects of the ionizing radiation on the bacterial and the fungal community structure (16S and 18S rDNA DGGE), the degradation of {sup 14}C-labeled wheat straw or uniformly ring-labeled 2,4-dichlorophenoxyacetic acid, the development of the fungal biomass (ergosterol quantification) and the chemical composition of the soil organic matter ({sup 13}C CP/MAS NMR) were investigated. In half of the microcosms the soils were autoclaved and reinoculated

  7. Safety Aspects for Vertical Wall Breakwaters

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Burcharth, H. F.; Christiani, E.

    1996-01-01

    In this appendix some safety aspects in relation to vertical wall breakwaters are discussed. Breakwater structures such as vertical wall breakwaters are used under quite different conditions. The expected lifetime can be from 5 years (interim structure) to 100 years (permanent structure) and the ...

  8. Special aspects of motivation of the structural subdivisions of the state emergency service of Ukraine in terms of physical self-culture

    Directory of Open Access Journals (Sweden)

    A.I. Stetsenko

    2015-03-01

    Full Text Available Purpose: to determine the motivation of employees of structural subdivisions of the State Emergency Service of Ukraine to improve their level of professional competence by means of physical training. Material: questionnaire survey of 130 rescue workers aged 25 to 40 years. Results: the main motives of rescue team personnel for physical culture and sports activities are gain in physical health and professional competence, while performing rescue missions. It was established that, when on duty, most of the firefighters and rescue workers are not engaged in physical exercise at all; household chores and poor state of health in case of men prevent rescue team employees from doing exercises outside of working hours. It was found that fire-rescue specialists give preference to the development of muscle strength during professional physical trainings and would like to perform power exercises. Conclusions: the low level of motivation of current fire-rescue workers for physical self-improvement requires optimization of control over professional physical education in departments of the State Emergency Service of Ukraine.

  9. Alba from Thermoplasma volcanium belongs to α-NAT's: An insight into the structural aspects of Tv Alba and its acetylation by Tv Ard1.

    Science.gov (United States)

    Ma, Chao; Pathak, Chinar; Lee, Sang Jae; Lee, Ki-Young; Jang, Sun-Bok; Nam, Minjoo; Im, Hookang; Yoon, Hye-Jin; Lee, Bong-Jin

    2016-01-15

    The Alba superfamily proteins have been regarded as a conserved group of proteins in archaea and eukarya, which have shown to be important in nucleic acid binding, chromatic organization and gene regulation. These proteins often belong to the N-acetyltransferase (NAT) category (N(α)-acetyltransferases or N(ε)-acetyltransferases) and undergo post-translational modifications. Here, we report the crystal structure of Alba from Thermoplasma volcanium (Tv Alba) at 2.4 Å resolution. The acetylation of Tv Alba was monitored and the N-terminal of Tv Alba has been shown to interact with acetyl coenzyme A (Ac-CoA). The chemical shift perturbation experiments of Tv Alba were performed in the presence of Ac-CoA and/or Tv Ard1, another T. volcanium protein that treats Tv Alba as a substrate. To examine the DNA binding capabilities of Tv Alba alone and in the presence of Ac-CoA and/or Tv Ard1, EMSA experiments were carried out. It is shown that although Tv Alba binds to Ac-CoA, the acetylation of Tv Alba is not related with its binding to dsDNA, and the involvement of the N-terminus in Ac-CoA binding demonstrates that Tv Alba belongs to the N(α)-acetyltransferase family. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Iheringichthys labrosus (Siluriformes: Pimelodidae in the Piquiri River, Paraná, Brazil: population structure and some aspects of its reproductive biology

    Directory of Open Access Journals (Sweden)

    Arlei J. Holzbach

    Full Text Available The purpose of this study was to analyze the population structure (spatial and temporal distribution, sex ratio, length distribution and length/weight relationship and reproductive biology of Iheringichthys labrosus. This species is of importance as fisheries resource in the Paraná River basin. Fish were sampled, bimonthly, with gill and trammel nets at three sampling sites (Campina, Apertado and Altônia, located in the Piquiri River, between November 2002 and September 2003. In this study, 164 individuals were collected; the largest capture occurred in Campina site, with 209.88 individuals/1000 m² of net for 24 hours, while the shift of largest capture was night time (N and the month was July. Females occurred in larger numbers than males in all periods. The growth was allometric positive and the reproduction period was from the beginning of September to the end of December, with the majority of the individuals showing a standard length between 13.0 and 20.0 cm.

  11. Effects of synthetic and naturally occurring flavonoids on Na+, K+-ATPase: Aspects of the structure-activity relationship and action mechanism

    International Nuclear Information System (INIS)

    Hirano, T.; Oka, K.; Akiba, M.

    1989-01-01

    A comparative study was made of the effects of 15 synthetic and naturally occurring flavonoids on the hydrolytic activity of Na + , K + -adenosine triphosphatase (ATPase). Twelve of the flavonoids examined were mono-hydroxy or mono-methoxy derivatives. All inhibited Na + , K + -ATPase from dog kidney cortex when present at concentrations from 40-1000 μM. Flavones possessing cyclohexyl instead of the phenyl group were the most potent with IC 50 at 257-320 μM. Structure-activity relationships were observed among the following mono-substituted flavones as: (i) 2-cyclohexyl-benzopyran-4-one much-gt 2-phenyl-benzopyran-4-one; (ii) 2-cyclohexyl-7-hydroxybenzopyran-4-one > 2-cyclohexyl-6-hydroxy-benzopyran-4-one > 2-cyclohexyl-5-hydroxybenzopyran-4-one. Some flavonoids showing potent inhibitory activity were also examined for ouabain-displacement activity on human erythrocytes. Hardly and of the flavonoids were able to block [ 3 H] ouabain binding to erythrocytes. These results suggest that the mechanism by which flavonoid block Na + , K + -ATPase is not related to the cardiac glycoside-specific binding site(s) of this enzyme

  12. Effects of synthetic and naturally occurring flavonoids on Na sup + , K sup + -ATPase: Aspects of the structure-activity relationship and action mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Hirano, T.; Oka, K.; Akiba, M. (Tokyo College of Pharmacy (Japan))

    1989-01-01

    A comparative study was made of the effects of 15 synthetic and naturally occurring flavonoids on the hydrolytic activity of Na{sup +}, K{sup +} -adenosine triphosphatase (ATPase). Twelve of the flavonoids examined were mono-hydroxy or mono-methoxy derivatives. All inhibited Na{sup +}, K{sup +} -ATPase from dog kidney cortex when present at concentrations from 40-1000 {mu}M. Flavones possessing cyclohexyl instead of the phenyl group were the most potent with IC{sub 50} at 257-320 {mu}M. Structure-activity relationships were observed among the following mono-substituted flavones as: (i) 2-cyclohexyl-benzopyran-4-one {much gt} 2-phenyl-benzopyran-4-one; (ii) 2-cyclohexyl-7-hydroxybenzopyran-4-one {gt} 2-cyclohexyl-6-hydroxy-benzopyran-4-one {gt} 2-cyclohexyl-5-hydroxybenzopyran-4-one. Some flavonoids showing potent inhibitory activity were also examined for ouabain-displacement activity on human erythrocytes. Hardly and of the flavonoids were able to block ({sup 3}H) ouabain binding to erythrocytes. These results suggest that the mechanism by which flavonoid block Na{sup +}, K{sup +} -ATPase is not related to the cardiac glycoside-specific binding site(s) of this enzyme.

  13. Population structure and reproductive aspects of puffer fish Sphoeroides annulatus (Jenyns, 1842 (Osteichthyes: Tetraodontidae, landed in Teacapán, Sinaloa, Mexico

    Directory of Open Access Journals (Sweden)

    María Candelaria Valdez-Pineda

    2014-03-01

    Full Text Available The puffer fish Sphoeroides annulatus is an important target species for the artisanal fishing fleets of NW Mexico. To obtain information on population structure of the local stock, we determined the total length and total weight (TL and TW ranges, sex ratio and reproductive stages of 745 specimens of this species, landed from May 2010 to April 2011 in Teacapán, Sinaloa, NW Mexico. TL ranged from 15 to 40 cm and TW from 100 to 1600 g. There were no differences between mean TL (27.41 ± 4.14 cm and TW (534.5 ± 226.0 g of males and females respectively. Sex ratio was not significantly different (χ2 = 0.03, P > 0.05 from 1F:1M. The length-weight relationship for both sexes was TW = 0.044TL2.815, R² = 0.895. The value of the slope b was significantly lower than 3 (P < 0.05, and indicated negative allometric growth. The distribution of maturity stages indicated one main reproductive period from June to September and one less intense, from November to December for females, and in December for males. Size at first maturity (L50% of females was 26.52 cm and that of males was 27.41 cm.

  14. Taxonomic and epidemiological aspects of the bovine viral diarrhoea virus 2 species through the observation of the secondary structures in the 5' genomic untranslated region

    Directory of Open Access Journals (Sweden)

    Massimo Giangaspero

    2008-06-01

    Full Text Available Bovine viral diarrhoea virus 2 (BVDV-2 strains demonstrated in cattle, sheep and adventitious contaminants of biological products were evaluated by the palindromic nucleotide substitutions (PNS method at the three variable loci (V1, V2 and V3 in the 5’ untranslated region (UTR, to determine their taxonomic status. Variation in conserved genomic sequences was used as a parameter for the epidemiological evaluation of the species in relation to geographic distribution, animal host and virulence. Four genotypes were identified within the species. Taxonomic segregation corresponded to geographic distribution of genotype variants. Genotype 2a was distributed worldwide and was also the only genotype that was circulating in sheep and cattle. Genotypes 2b, 2c and 2d were restricted to South America. Genotypes 2a and 2d were related to the contamination of biological products. Genetic variation could be related to the spread of BVDV-2 species variants in different geographic areas. Chronologically, the species emerged in North America in 1978 and spread to the United Kingdom and Japan, continental Europe, South America and New Zealand. Correlation between clinical features related with isolation of BVDV-2 strains and genetic variation indicated that subgenotype 1, variant 4 of genotype 2a, was related to a haemorrhagic syndrome. These observations suggest that the evaluation of genomic secondary structures, by identifying markers for expression of virus biological activities and species evolutionary history, may be a useful tool for the epidemiological evaluation of BVDV-2 species and possibly of other species of the genus Pestivirus.

  15. Aspect-Oriented Programming

    NARCIS (Netherlands)

    Bergmans, Lodewijk; Videira Lopes, Cristina; Moreira, Ana; Demeyer, Serge

    1999-01-01

    Aspect-oriented programming is a promising idea that can improve the quality of software by reduce the problem of code tangling and improving the separation of concerns. At ECOOP'97, the first AOP workshop brought together a number of researchers interested in aspect-orientation. At ECOOP'98, during

  16. Lexical and Grammatical Aspect

    NARCIS (Netherlands)

    van Hout, Angeliek; Lidz, Jeffrey; Snyder, William; Pater, Joe

    The temporality of a given situation ‘out there in the world’ can be described in many ways. Tense and aspect offer the essential parameters. Lexical aspect characterizes event descriptions; a situation with a sleeping child can be referred to as a state of affairs (be asleep) or as a happening

  17. Cultural Aspects of Suicide

    Directory of Open Access Journals (Sweden)

    Hari D. Maharajh

    2005-01-01

    Full Text Available Undefined cultural factors cannot be dismissed and significantly contribute to the worldwide incidence of death by suicide. Culture is an all embracing term and defines the relationship of an individual to his environment. This study seeks to investigate the effect of culture on suicide both regionally and internationally. Culture-bound syndrome with suicidal behaviours specific to a particular culture or geographical region are discussed. Opinions are divided as to the status of religious martyrs. The law itself is silent on many aspects of suicidal behaviour and despite decriminalization of suicide as self-murder, the latter remains on the statutes of many developing countries. The Caribbean region is of concern due to its steady rise in mean suicide rate, especially in Trinidad and Tobago where socio-cultural factors are instrumental in influencing suicidal behaviour. These include transgenerational cultural conflicts, psycho-social problems, media exposure, unemployment, social distress, religion and family structure. The methods used are attributed to accessibility and lethality. Ingestion of poisonous substances is most popular followed by hanging. The gender differences seen with regard to suicidality can also be attributed to gender related psychopathology and psychosocial differences in help-seeking behaviour. These are influenced by the cultural environment to which the individual is exposed. Culture provides coping strategies to individuals; as civilization advances many of these coping mechanisms are lost unclothing the genetic predisposition of vulnerable groups. In the management of suicidal behaviour, a system of therapeutic re-culturation is needed with an emphasis on relevant culture- based therapies.

  18. General safety aspects

    International Nuclear Information System (INIS)

    1998-01-01

    In this part next aspects are described: (1) Priority to safety; (2) Financial and human resources;; (3) Human factor; (4) Operator's quality assurance system; (5) Safety assessment and Verification; (6) Radiation protection and (7) Emergency preparedness

  19. Foundational aspects of security

    DEFF Research Database (Denmark)

    Chatzikokolakis, Konstantinos; Mödersheim, Sebastian Alexander; Palamidessi, Catuscia

    2014-01-01

    This Special Issue of the Journal of Computer Security focuses on foundational aspects of security, which in recent years have helped change much of the way we think about and approach system security.......This Special Issue of the Journal of Computer Security focuses on foundational aspects of security, which in recent years have helped change much of the way we think about and approach system security....

  20. Solid surfaces : some theoretical aspects

    International Nuclear Information System (INIS)

    Das, M.P.

    1978-01-01

    An appraisal of the current situation concerning some of the theoretical aspects of solid surfaces is presented. First of all the characterization of the surfaces that involves the surface geometry and atomic composition for both the clean and adsorbed surfaces is discussed. Under this, the methods for determining the surface structure (such as low energy electron diffraction, field electron and field ion microscopy, photo emission spectroscopy and atomic scattering) and methods for determining the surface composition by the Auger electron spectroscopy are outlined. In the second part, emphasis is on the electronic structure of the clean and adsorbed surfaces. The measurements of ultra-violet and X-ray photo electron spectra are shown to yield the information about the surface electronic structure. In this context the many body effects such as, shake-up and relaxation energy etc. are discussed. Finally the status of the theory in relation to the experiments on angular resolved and polarization dependent photo emission are presented. (auth.)

  1. Biological and geophysical aspects of coastal structures

    Digital Repository Service at National Institute of Oceanography (India)

    Ramana, M.V.

    Geological processes, that occur in the nearshore environment : The nearshore, environments have been strongly influencEd. by sealevel changes throughout the geological history. Much of the shallow-water region is also strongly affectEd. by waves...

  2. Structural, electrical and thermodynamical aspects of hydrogenated ...

    Indian Academy of Sciences (India)

    Powder XRD results show that the lattice constants and unit cell volume of the alloy increase after hydrogen storage. ... The thermodynamic parameters viz. the relative partial molar enthalpy ( ) and relative partial molar entropy ( ) of dissolved hydrogen, are found to be in the range 8–18 kJ (mol H)-1 and 25–63 JK-1 ...

  3. Structural integrity aspects of reactor safety

    Indian Academy of Sciences (India)

    The overall goal of nuclear power plant safety is to protect individuals, society and the environment from undue radiological hazard so that nuclear power production does not significantly add to the health risks to which individuals and society are already exposed. This paper addresses the safety principles followed during ...

  4. Some structural aspects of precapillary vessels.

    Science.gov (United States)

    Hammersen, F; Hammersen, E

    1984-01-01

    According to the present state of the art, the former Chambers-Zweifach conception is no longer tenable as the ubiquitous module of microvascular organization. Any attempt to define the consecutive segments of precapillary vessels in a random collection of sectioned tissues is impaired by the extreme scatter of variations and the lack of additional criteria necessary for a distinct classification. With these inadequacies in mind, arterioles, terminal arterioles, and their precapillary segments (sphincters?) are identified by applying the following parameters: luminal diameter, composition of the subendothelial space, and thickness as well as completeness of the media. Endothelial components of particular functional significance are different types of cytoplasmic filaments and myoendothelial junctions. The former serve as a cytoskeleton and may provide a mechanism to adapt endothelial tensile strength to variations of shearing forces. The latter appear to be sites of firm intercellular attachment and of electrotonic coupling of the endothelium to the underlying smooth-muscle cells. The former unanimously accepted helicoidal arrangement of vascular smooth muscle (VSM) must be modified according to most recent findings, and the tridimensional shape of VSM and its transition to pericyte-like elements remain to be further elucidated. Future effects, from which solutions to the many open problems may be expected, must therefore aim at combined vital-, light-, and electron-microscopic studies of the methodically accessible microvascular beds. This necessity has already been recognized, and first promising steps have been taken.

  5. Aspect and Argument structure in adjectival passives

    OpenAIRE

    García-Pardo, Alfredo

    2017-01-01

    This paper investigates the patterns regarding the (un)availability of by-phrases and agent-oriented modification in adjectival passives in Spanish. Departing from the observation that adjectival participles derived from change-of-state verbs ban agent-oriented modification but those derived from stative causative verbs allow it, I put forth a novel theoretical account that derives the restrictions solely from the Aktionsart of the underlying verbal predicate, syntactically modelled and indep...

  6. Structural, electrical and thermodynamical aspects of hydrogenated ...

    Indian Academy of Sciences (India)

    Unknown

    Powder XRD results show that the lattice constants and unit cell volume of the alloy increase after hydrogen ... ence of ∆H on the hydrogen concentration, X, the different phases [α, α + β, β] and phase boundaries of the alloy-. H system are identified. ... so difficult to store that its use as a fuel has been limited. It has been well ...

  7. Structural aspects of proton-pumping ATPases

    NARCIS (Netherlands)

    Walker, J. E.; Fearnley, I. M.; Lutter, R.; Todd, R. J.; Runswick, M. J.

    1990-01-01

    ATP synthase is found in bacteria, chloroplasts and mitochondria. The simplest known example of such an enzyme is that in the eubacterium Escherichia coli; it is a membrane-bound assembly of eight different polypeptides assembled with a stoichiometry of alpha 3 beta 3 gamma 1 delta 1 epsilon 1

  8. Structural integrity aspects of reactor safety

    Indian Academy of Sciences (India)

    compared to the number of cycles anticipated during service. This satisfies the second ... vious fatigue loading is much more than the maximum load anticipated during service. This satisfies the third stage of ... A probabilistic analysis of primary heat transport system of Indian Pressurized Heavy Water reactor was performed ...

  9. Structural aspects of superconducting fusion magnets

    International Nuclear Information System (INIS)

    Reich, M.; Lehner, J.; Powell, J.

    1977-01-01

    Some methods for studying various static, dynamic, elastic-plastic, and fracture mechanics problems of superconducting magnets are described. Sample solutions are given for the UWMAK-I magnet. Finite element calculations were used

  10. Structural, electrical and thermodynamical aspects of hydrogenated ...

    Indian Academy of Sciences (India)

    Unknown

    60°C. Also the enthalpy and entropy of system have been calcu- lated using Vant' Hoff plot. The measurement of thermal conductivity, thermal diffusivity and specific heat of the material and its hydride have not been carried out at room temperature using transient plane source (TPS) technique. 2. Experimental. 2.1 Material ...

  11. DEFINICIONES PERSONALES Y ASPECTOS ESTRUCTURALES DEL CONCEPTO DE LÍMITE FINITO DE UNA FUNCIÓN EN UN PUNTO (Personal Definitions and Structural Aspects of the Concept of Finite Limit of a Function at one Point

    Directory of Open Access Journals (Sweden)

    Juan Francisco Ruiz-Hidalgo

    2013-03-01

    Full Text Available Describimos e interpretamos las definiciones aportadas por un grupo de estudiantes de bachillerato sobre el concepto de límite finito de una función en un punto en términos de aspectos estructurales, compilados y sintetizados de investigaciones previas. Los aspectos estructurales son la interpretación como objeto o como proceso de la noción de límite, los algoritmos y las destrezas prácticas para su cálculo, su alcanzabilidad y su rebasabilidad. A partir de ellos, analizamos las definiciones recogidas. Entre los resultados, destacamos la riqueza de significado de estas definiciones por razón del carácter no alcanzable y no rebasable atribuido al límite y por su consideración dual como objeto o proceso. We describe and interpret the individual definitions of a group of non-compulsory secondary education students related to the concept of finite limit of a function at one point in terms of structural aspects compiled and synthesized from prior research. These aspects are the interpretation of the limit notion as an object or a process, its exact or approximate character, the algorithms and practical skills for its calculation, its reachability and its possibility of being exceeded. Among the results we point out the richness of meaning from these definitions by the not reachable and not exceedable attributed character of the limit, and also by the dual consideration of the limit as an object or process.

  12. Quantifying Quality Aspects of Multimodal Interactive Systems

    CERN Document Server

    Kühnel, Christine

    2012-01-01

    This book systematically addresses the quantification of quality aspects of multimodal interactive systems. The conceptual structure is based on a schematic view on human-computer interaction where the user interacts with the system and perceives it via input and output interfaces. Thus, aspects of multimodal interaction are analyzed first, followed by a discussion of the evaluation of output and input and concluding with a view on the evaluation of a complete system.

  13. Organisational aspects of care.

    Science.gov (United States)

    Bloomfield, Jacqueline; Pegram, Anne

    2015-03-04

    Organisational aspects of care, the second essential skills cluster, identifies the need for registered nurses to systematically assess, plan and provide holistic patient care in accordance with individual needs. Safeguarding, supporting and protecting adults and children in vulnerable situations; leading, co-ordinating and managing care; functioning as an effective and confident member of the multidisciplinary team; and managing risk while maintaining a safe environment for patients and colleagues, are vital aspects of this cluster. This article discusses the roles and responsibilities of the newly registered graduate nurse. Throughout their education, nursing students work towards attaining this knowledge and these skills in preparation for their future roles as nurses.

  14. Toxicological aspects of water

    International Nuclear Information System (INIS)

    Garcia Puertas, P.

    1991-01-01

    Different toxicological aspects of water have been studied, remarking the activity of various chemical substances in the organism. These substances are divided in: trace metals (Sb, As, Cd, Zn, Cu, Cr, Fe, Mn, Hg, Ni, Pb, Se), other contaminants (CN-, polycyclic aromatic hydrocarbons, phenols, pesticides, detergents) and radioactivity. Finally, some considerations on this subject are made [es

  15. DESIGN ASPECTS IN MACHINE TOOLS EVOLUTION

    Directory of Open Access Journals (Sweden)

    CALOTA Lavinia Alexandra

    2010-11-01

    Full Text Available The paper proposes to present some important aspects in the design evolution of some representative types of machine tools, as the evolution of some basic structural elements which compose machine tools majority. The paper, also, present the aspects regarding the machine tools aesthetics, like a result of shape modeling, bounded by the functional role, and with the possibilities of artistical modeling of the structural-geometrical elements, respecting the essential principles of the composition and design, such as: the proportion, the rhythm, the symmetry and the contrast. Respecting these principles were determined the ensemble constructive shapes for milling machines.

  16. Behavioural aspects of terrorism.

    Science.gov (United States)

    Leistedt, Samuel J

    2013-05-10

    Behavioural and social sciences are useful in collecting and analysing intelligence data, understanding terrorism, and developing strategies to combat terrorism. This article aims to examine the psychopathological concepts of terrorism and discusses the developing roles for behavioural scientists. A systematic review was conducted of studies investigating behavioural aspects of terrorism. These studies were identified by a systematic search of databases, textbooks, and a supplementary manual search of references. Several fundamental concepts were identified that continue to influence the motives and the majority of the behaviours of those who support or engage in this kind of specific violence. Regardless of the psychological aspects and new roles for psychiatrists, the behavioural sciences will continue to be called upon to assist in developing better methods to gather and analyse intelligence, to understand terrorism, and perhaps to stem the radicalisation process. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  17. MARKETING MIX THEORETICAL ASPECTS

    OpenAIRE

    Margarita Išoraitė

    2016-01-01

    Aim of article is to analyze marketing mix theoretical aspects. The article discusses that marketing mix is one of the main objectives of the marketing mix elements for setting objectives and marketing budget measures. The importance of each element depends not only on the company and its activities, but also on the competition and time. All marketing elements are interrelated and should be seen in the whole of their actions. Some items may have greater importance than others; it depends main...

  18. Futurological aspects of globalisation

    OpenAIRE

    Kostić Aleksandar V.

    2013-01-01

    The author examines futurological aspects of globalization having in mind various models of historical processes. He describes the changes as "futuroshock", thus presenting a dilemma whether the changes are only a momentum or a pre-planned concept. He especially stresses the Toffler’s conclusion that turns a new page in futurology - examining the dangers that follow the changes. According to him, predictions are made with the help of practically all the sciences in two basic directions: explo...

  19. Aspects of B physics

    Energy Technology Data Exchange (ETDEWEB)

    Gaillard, M.K.

    1987-10-14

    Various aspects of weak decays are commented on. Probing of the standard model and of phenomena beyond the standard model are discussed, followed by a theoretical view of B mesons and some experimental observations on B mesons. The point is made that any data on B decay would be interesting in that it would provide powerful new constraints in analyses of the standard model and extensions thereof. (LEW)

  20. Criminal Aspects of Pornography

    OpenAIRE

    Svoboda, Filip

    2015-01-01

    Criminal Aspects of Pornography Summary The main purpose of this thesis is to introduce the phenomenon of pornography in terms of criminal law, to point out flaws in the current relevant criminal legislation in the Czech Republic and to propose a possible solution in a form of potential legislative changes. The thesis is composed of five chapters. The first chapter deals with definition issue of vague legal term of "pornography" and other related terms ("child pornography", "hardcore pornogra...

  1. ETHICAL ASPECTS OF SUSTAINABILITY

    OpenAIRE

    Amantova-Salmane, Liene

    2015-01-01

    Ethics can be defined as a reflection on nature and a definition of “the good”. Individuals value qualities and things dissimilarly, most visibly, but they also value their goods in different ways, in different relations to each other, for different reasons, and to different ends. These differences are very applicable to sustainability. In other words, sustainability cannot be achieved without attention to its ethical dimensions. The aim of this research is to examine the ethical aspects of s...

  2. LNG project - contractual aspects

    Energy Technology Data Exchange (ETDEWEB)

    Goncalves, Bruno Almeida

    2008-07-01

    This paper intends to provide from the legal point of view an outline of the main challenges of a LNG project in the upstream, regulatory aspects, liquefaction, financing and midstream through a basic checklist; an overview of the contractual complexity of a LNG project; some basic discussion of particular LNG contract clauses; and a comparative analysis between the classic clauses of a Gas Transportation Agreement (GTA) through a gas pipeline and LNG logistic. (author)

  3. Psychosocial Aspects of Obesity.

    Science.gov (United States)

    Beck, Amy R

    2016-01-01

    This article is the sixth in a series of the comorbidities of childhood obesity and reviews psychosocial aspects with a focus on weight-based victimization and discrimination stemming from weight bias and stigma. Outcomes from these bullying and discriminatory experiences are pervasive and impact youth across all settings, including school. Lastly, this article provides recommendations on how to reduce bias and stigma to better serve these students in the school environment. © 2015 The Author(s).

  4. Criminal Aspects of Artificial Abortion

    OpenAIRE

    Hartmanová, Leona

    2016-01-01

    Criminal Aspects of Artificial Abortion This diploma thesis deals with the issue of artificial abortion, especially its criminal aspects. Legal aspects are not the most important aspects of artificial abortion. Social, ethical or ideological aspects are of the same importance but this diploma thesis cannot analyse all of them. The main issue with artificial abortion is whether it is possible to force a pregnant woman to carry a child and give birth to a child when she cannot or does not want ...

  5. Nutritional Aspects of Dysphagia Management.

    Science.gov (United States)

    Gallegos, C; Brito-de la Fuente, E; Clavé, P; Costa, A; Assegehegn, G

    This chapter describes the nutritional aspects of dysphagia management by starting with the definition of these two conditions (dysphagia and malnutrition) that share three main clinical characteristics: (a) their prevalence is very high, (b) they can lead to severe complications, and (c) they are frequently underrecognized and neglected conditions. From an anatomical standpoint, dysphagia can result from oropharyngeal and/or esophageal causes; from a pathophysiological perspective, dysphagia can be caused by organic or structural diseases (either benign or malignant) or diseases causing impaired physiology (mainly motility and/or perception disorders). This chapter gathers up-to-date information on the screening and diagnosis of oropharyngeal dysphagia, the consequences of dysphagia (aspiration pneumonia, malnutrition, and dehydration), and on the nutritional management of dysphagic patients. Concerning this last topic, this chapter reviews the rheological aspects of swallowing and dysphagia (including shear and elongational flows) and its influence on the characteristics of the enteral nutrition for dysphagia management (solid/semisolid foods and thickened liquids; ready-to-use oral nutritional supplements and thickening powders), with special focus on the real characteristics of the bolus after mixing with human saliva. © 2017 Elsevier Inc. All rights reserved.

  6. AspectJ in action practical aspect-oriented programming

    CERN Document Server

    Laddad, Ramnivas

    2003-01-01

    A guide to aspect-oriented programming and the AspectJ language, this book provides code examples that enable quick implementation of functionality in a system. Thorough introductions to AOP and AspectJ will help developers learn or advance their knowledge of AspectJ. Examples of everyday situations in which AspectJ solutions can be applied, such as logging, policy enforcement, resource pooling, business logic, thread-safety, authentication and authorization, and transaction management are provided. In addition, design patterns and idioms are covered, as is business rule implementation. The latest technologies, such as JEES, JAAS, and log4j, are explained and connected with AspectJ.

  7. Strategic Aspects of Bundling

    International Nuclear Information System (INIS)

    Podesta, Marion

    2008-01-01

    The increase of bundle supply has become widespread in several sectors (for instance in telecommunications and energy fields). This paper review relates strategic aspects of bundling. The main purpose of this paper is to analyze profitability of bundling strategies according to the degree of competition and the characteristics of goods. Moreover, bundling can be used as price discrimination tool, screening device or entry barriers. In monopoly case bundling strategy is efficient to sort consumers in different categories in order to capture a maximum of surplus. However, when competition increases, the profitability on bundling strategies depends on correlation of consumers' reservations values. (author)

  8. Radiographic aspects of xeroradiography

    International Nuclear Information System (INIS)

    Rao, G.U.V.; Fatouros, P.P.

    1980-01-01

    The quality of a conventional radiographic image can be characterized in terms of five basic parameters; density, contrast, latitude, resolution and noise. Since xeroradiographic images exhibit very limited broad area contrasts, and image formation is predominantly due to edge enhancement, a straightforward description of image quality using the same five parameters is not adequate. A detailed study was made of the radiographic aspects of xeroradiography with special reference to mammography, and a summary of major findings to date with appropriate references to published papers is presented

  9. Analytic aspects of convexity

    CERN Document Server

    Colesanti, Andrea; Gronchi, Paolo

    2018-01-01

    This book presents the proceedings of the international conference Analytic Aspects in Convexity, which was held in Rome in October 2016. It offers a collection of selected articles, written by some of the world’s leading experts in the field of Convex Geometry, on recent developments in this area: theory of valuations; geometric inequalities; affine geometry; and curvature measures. The book will be of interest to a broad readership, from those involved in Convex Geometry, to those focusing on Functional Analysis, Harmonic Analysis, Differential Geometry, or PDEs. The book is a addressed to PhD students and researchers, interested in Convex Geometry and its links to analysis.

  10. Radiological aspects of Arthroplasties

    International Nuclear Information System (INIS)

    Garcia, Sara Eugenia; Barragan, John Henry; Narvaez, Jorge Andres

    2008-01-01

    The development of new surgical techniques, of new prosthetic materials, and the increase in life expectancy with greater coverage of health services has ugmented the performance of hip replacements in our country. The radiologist should be familiar with the different surgical techniques and prosthetic devices, the evaluation of its components and associated complications. The most frequently performed arthroplasties are: shoulder, elbow, hip and knee replacement. This article reviews the most frequent prosthetic devices used, the radiological aspects of arthroplasties and their most common complications.

  11. SAFETY ASPECTS OF SPORTS COMPETITION

    Directory of Open Access Journals (Sweden)

    Srećko Novaković

    2011-09-01

    Full Text Available Sport, as an activity of public interest in contemporary conditions of life,has an important role in almost every state. Financial and security of participation of the state in the sports field, through the budgets of all levels are important issues regardless of the status and relationships of government and non-governmental organizations and sports associations. Cooperation and clear definition of security responsibilities between public authorities and sports clubs is essential and widely accepted phenomenon. The causes of conflict in sport competitions are polyvalent. It affects the study of this type of security phenomena that must be approached from different aspects. The causes of conflict in sports competitions may be direct and indirect, structural, economic - social, political and cultural - perceptual. All together they contribute to the occurrence of conflict and measuring the occurrence and development of modern security phenomenon in sport competitions

  12. Sensory aspects of movement disorders

    Science.gov (United States)

    Patel, Neepa; Jankovic, Joseph; Hallett, Mark

    2016-01-01

    Movement disorders, which include disorders such as Parkinson’s disease, dystonia, Tourette’s syndrome, restless legs syndrome, and akathisia, have traditionally been considered to be disorders of impaired motor control resulting predominantly from dysfunction of the basal ganglia. This notion has been revised largely because of increasing recognition of associated behavioural, psychiatric, autonomic, and other non-motor symptoms. The sensory aspects of movement disorders include intrinsic sensory abnormalities and the effects of external sensory input on the underlying motor abnormality. The basal ganglia, cerebellum, thalamus, and their connections, coupled with altered sensory input, seem to play a key part in abnormal sensorimotor integration. However, more investigation into the phenomenology and physiological basis of sensory abnormalities, and about the role of the basal ganglia, cerebellum, and related structures in somatosensory processing, and its effect on motor control, is needed. PMID:24331796

  13. J. Piaget's theory of intelligence: operational aspect

    Directory of Open Access Journals (Sweden)

    Xenia Naidenova

    2001-08-01

    Full Text Available The Piaget's theory of intelligence is considered from the point of view of genesis and gradual development of human thinking operations. Attention is given to operational aspects of cognitive structures and knowledge. The significance of the Piaget's theory of intelligence is revealed for modeling conceptual reasoning in the framework of artificial intelligence.

  14. Practical aspects of MRI of the prostate

    Directory of Open Access Journals (Sweden)

    Dragoș Cuzino

    2014-12-01

    Full Text Available The article presents the main aspects of sectional anatomy, lymph nodes and adjacent structures as well as MRI examination standard protocol for prostate cancer diagnosis. Using MRI multiparametric examination we succeed in classifying efficiently the malignant prostatic tumors using PI- RADS system. Also, using MRI multiparametric examination we can evaluate the effectiveness of prostate cancer treatment

  15. Historical Aspects of Echinococcosis.

    Science.gov (United States)

    Eckert, J; Thompson, R C A

    2017-01-01

    Echinococcosis is a zoonosis whose history dates back to antiquity. This article provides an overview on the general history of echinococcosis, including the elucidation of Echinococcus life cycles and the long controversy on the aetiology of the cystic and alveolar forms of echinococcosis (CE and AE), lasting about 100years since the middle of the 19th century. Furthermore, selected historical aspects of some fields of echinococcosis research are discussed and compared with our current knowledge, such as geographic distribution and epidemiology of CE (Echinococcus granulosus) and AE (Echinococcus multilocularis), clinical aspects and pathology, diagnosis in humans and animals, treatment (with focus on chemotherapy), control and basic research. A short paragraph is devoted to the neotropical forms of echinococcosis, caused by Echinococcus vogeli and Echinococcus oligarthrus. In this context the achievements of some ancestral pioneers of echinococcosis research are particularly highlighted and appreciated. Finally, the role of associations, international organizations (World Health Organization and others) and international working groups in echinococcosis research and control is briefly outlined. The retrospective reveals both the admirable achievements of our ancestors and the scientific progress of more recent times. But, it also shows the gaps in our knowledge, skills and resources that we need to control or even eradicate echinococcosis. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Diabetic patients: Psychological aspects.

    Science.gov (United States)

    Adili, Fatemeh; Larijani, Bagher; Haghighatpanah, Mohammadreza

    2006-11-01

    This study was undertaken to consider the psychological aspect of diabetes with regard to improving clinical outcomes. The review was limited to literature reports on the causes, solutions, and treatments of some common psychological problems known to complicate diabetes management. A literature search was undertaken using Pub-Med, CINAHL, Proquest, Elsevier, Blackwell Synergy, Ovid, Ebsco, Rose net, and Google websites, including studies published in English journals between 1995 and 2006. Therefore about 88 articles were selected based on the inclusion criteria. In earlier studies, relatively little empirical research was found to substantiate the effect of psychological counseling in complicated diabetes. The greatest deficits were seen in areas of mental health, self-esteem parent impact, and family cohesion. There were some different factors, which influence the psychological aspect of diabetic patients, such as age, gender, place of living, familial and social support, motivation, energy, life satisfaction, and lifestyle. There are various types of solutions for coping with the psychological problems in diabetic clients. The most essential solution lies in educating the patients and healthcare providers on the subject. Before initiating each educational intervention, a thorough assessment would be crucial. Treatment plans may benefit from cognitive behavior therapy (CBT), behavior family therapy, improving family communication, problem-solving skills, and providing motivation for diabetic patients. Moreover, it seems that the close collaboration between diabetologists and psychologists would be fruitful.

  17. Enantiostylous types of Cassiinae species (Fabaceae-Caesalpinioideae).

    Science.gov (United States)

    Almeida, N M; Cotarelli, V M; Souza, D P; Novo, R R; Siqueira Filho, J A; Oliveira, P E; Castro, C C

    2015-05-01

    Species of the subtribe Cassiinae present a wide diversity of floral types. Until recently it was considered that this diversity did not extend to their reproductive mechanisms. However, studies have recorded some variations in the enantiostylous pattern in this plant group. This study aims to investigate the morphological and functional variations of enantiostyly in species of the subtribe Cassiinae. Additionally, it proposes the recognition of enantiostylous types (ET) based on pollen deposition and capture mode. Morphological data were collected in fresh and fixed (alcohol 70%) buds and flowers, and also using photos and rehydrated material from herbarium sheets, for a total of 59 species. The parameters used to establish the ETs were pollination type, nature of pollen deposition on the pollinator body, deposition type, number of petals involved in pollen deposition, and pollen pathway. Morpho-functional features allowed the recognition of seven enantiostylous types (Flexuosa, Cana, Macranthera, Martiana, Amiciella, Repens and Ramosa) that present several levels of complexity. The type Ramosa was the most common and the Cana type was the least common. The types Repens, Martiana and Flexuosa do not have reciprocal pollen deposition, thus species with these types may be considered atypical. The groups resulting from similarity analysis partially coincide with the clades proposed in phylogenetic studies of Cassiinae. The recognition of functional ETs is important for understanding the evolution of reproductive strategies of Cassiinae species, and indicates an interesting line of investigation of enantiostyly in other plant groups. © 2014 German Botanical Society and The Royal Botanical Society of the Netherlands.

  18. Early Aspects: Aspect-Oriented Requirements Engineering and Architecture Design

    NARCIS (Netherlands)

    Tekinerdogan, B.; Moreira, Ana; Araújo, João; Clements, Paul

    2004-01-01

    This paper reports on the third Early Aspects: Aspect-Oriented Requirements Engineering and Architecture Design Workshop, which has been held in Lancaster, UK, on March 21, 2004. The workshop included a presentation session and working sessions in which the particular topics on early aspects were

  19. MACROECONOMIC ASPECTS OF COMPETITIVENESS

    Directory of Open Access Journals (Sweden)

    Oleg Hooke

    2017-09-01

    Full Text Available In the process of globalization of world economic processes, the role of individual national economies increases, comparative advantages of the development of a country are formed, and their competitiveness is ensured. That is why it is worth emphasizing the importance of increasing the competitiveness of each individual country, based on its internal capacity. In a broad aspect, the competitiveness of the national economy is perceived as the ability of the country to ensure the balance of its external proportions and to avoid those constraints imposed by the foreign economic sphere, to self-organizing the improvement of their world economic ties. The competitiveness of the economy at the macro level is associated with the duration of the cycle of reproduction of the main productive assets and, accordingly, the jobs, productive forces of society and determined by the overall economic efficiency of investment. The criteria of competitiveness of the national economy are the growth of social productivity of labor, increase of social and economic efficiency of production and standard of living of the population. The competitiveness of the national economy determines sustainable socio-economic development of the country, as well as sustainable development predetermines the competitiveness of not only the country, but also all its levels. Scientific results are obtained using special methods of research of economic objects and phenomena, that is, based on the correlation and regressive, comparative analysis (establishing the relationship between the indicator factor, as well as economic modeling. Findings. Generalizing analysis and the importance of the macroeconomic aspect of competitiveness were used in the research paper, which will allow to better respond to the economic situation, in accordance with the trends of the “green” transformation of the economy; which in turn will solve important problems of the development and implementation of its

  20. Psychiatric aspects of burn

    Directory of Open Access Journals (Sweden)

    Dalal P

    2010-10-01

    Full Text Available Burn injuries and their subsequent treatment cause one of the most excruciating forms of pain imaginable. The psychological aspects of burn injury have been researched in different parts of the world, producing different outcomes. Studies have shown that greater levels of acute pain are associated with negative long-term psychological effects such as acute stress disorder, depression, suicidal ideation, and post-traumatic stress disorder for as long as 2 years after the initial burn injury. The concept of allostatic load is presented as a potential explanation for the relationship between acute pain and subsequent psychological outcomes. A biopsychosocial model is also presented as a means of obtaining better inpatient pain management and helping to mediate this relationship.

  1. Political and economic aspects

    International Nuclear Information System (INIS)

    O'Neil, C.

    1997-01-01

    The political and socio-economic aspects of oil and gas exploration in Canada's Arctic and the Beaufort Sea were reviewed. The federal government was very interested in developing the North because they saw oil and gas development in the North as a means of strengthening sovereignty claims. The projected profits from Northern oil and gas development were also very attractive, and after dealing with environmental and social concerns, the government granted the necessary drilling permits. The federal government also made allowances for huge tax incentives for the oil and gas companies to encourage exploration. Although oil has been found, large-scale production in the Beaufort Sea never materialized. During the period from 1984 to 1988, world prices for oil fell and it was no longer economical to undertake frontier production. Beaufort Sea operation were shut down as the oil industry changed its focus to more cost-effective reservoirs in southern Canada. 1 fig

  2. ADTT safety aspects

    International Nuclear Information System (INIS)

    Thedeen, T.

    1997-01-01

    Beside the technical problems of ADTT which remain to be solved it is crucial for the ADTT progress that safety and economical aspects are considered already during the research and planning phases. Safety here stands for the converse of risk, negative consequences for human life and health and the environment together with the corresponding probabilities. The system to be considered includes all phases of an ADTT plant, a life cycle analysis (LCA). The risk analysis is useful for two purposes: comparison with other ways of handling nuclear waste, e.g. geological repository and for valuation of different construction designs. Due to lack of precise plans and adequate data the analysis will be more of a qualitative than quantitative type. The main risks appear in connection with repair and replacement work. 2 refs., 1 fig

  3. Formal aspects of resilience

    Directory of Open Access Journals (Sweden)

    Diana-Maria Drigă

    2015-12-01

    Full Text Available The concept of resilience has represented during the recent years a leading concern both in Romania, within the European Union and worldwide. Specialists in economics, management, finance, legal sciences, political sciences, sociology, psychology, grant a particular interest to this concept. Multidisciplinary research of resilience has materialized throughout the time in multiple conceptualizations and theorizing, but without being a consensus between specialists in terms of content, specificity and scope. Through this paper it is intended to clarify the concept of resilience, achieving an exploration of the evolution of this concept in ecological, social and economic environment. At the same time, the paper presents aspects of feedback mechanisms and proposes a formalization of resilience using the logic and mathematical analysis.

  4. Interdisciplinary aspects of turbulence

    CERN Document Server

    Kupka, Friedrich

    2008-01-01

    What do combustion engines, fusion reactors, weather forecast, ocean flows, our sun, and stellar explosions in outer space have in common? Of course, the physics and the length and time scales are vastly different in all cases, but it is also well known that in all of them, on some relevant length scales, the material flows that govern the dynamical and/or secular evolution of the systems are chaotic and often unpredictable: they are said to be turbulent. The interdisciplinary aspects of turbulence are brought together in this volume containing chapters written by experts from very different fields, including geophysics, astrophysics, and engineering. It covers several subjects on which considerable progress was made during the last decades, from questions concerning the very nature of turbulence to some practical applications. These subjects include: a basic introduction into turbulence, statistical mechanics and nonlinear dynamics, turbulent convection in stars, atmospheric turbulence in the context of nume...

  5. CUSTOMER LOYALTY THEORETICAL ASPECTS

    Directory of Open Access Journals (Sweden)

    Margarita IŠORAITĖ

    2016-08-01

    Full Text Available Customer loyalty - is a voluntary user solution for a long time to build relationships with the company. Loyalty is the user's desire for a long time to continue their relationship with a particular company, because loyal customers are those who purchase goods/services of the company from time to time. Loyalty can be treated as a customer desire, willingness to be a regular customer for a long time, buying and using the goods of the chosen companies by recommending them to friends and colleagues. Loyalty can be seen as a multi-dimension, covering behavioral and positional components, where positional aspect reflects customers' approach to business, while the behavioral dimension reveals a frequent and regular shopping, purchase quantity, size, range, availability, etc.

  6. ROBOTIC SURGERY: BIOETHICAL ASPECTS.

    Science.gov (United States)

    Siqueira-Batista, Rodrigo; Souza, Camila Ribeiro; Maia, Polyana Mendes; Siqueira, Sávio Lana

    2016-01-01

    The use of robots in surgery has been increasingly common today, allowing the emergence of numerous bioethical issues in this area. To present review of the ethical aspects of robot use in surgery. Search in Pubmed, SciELO and Lilacs crossing the headings "bioethics", "surgery", "ethics", "laparoscopy" and "robotic". Of the citations obtained, were selected 17 articles, which were used for the preparation of the article. It contains brief presentation on robotics, its inclusion in health and bioethical aspects, and the use of robots in surgery. Robotic surgery is a reality today in many hospitals, which makes essential bioethical reflection on the relationship between health professionals, automata and patients. A utilização de robôs em procedimentos cirúrgicos tem sido cada vez mais frequente na atualidade, o que permite a emergência de inúmeras questões bioéticas nesse âmbito. Apresentar revisão sobre os aspectos éticos dos usos de robôs em cirurgia. Realizou-se revisão nas bases de dados Pubmed, SciELO e Lilacs cruzando-se os descritores "bioética", "cirurgia", "ética", "laparoscopia" e "robótica". Do total de citações obtidas, selecionou-se 17 artigos, os quais foram utilizados para a elaboração do artigo. Ele contém breve apresentação sobre a robótica, sua inserção na saúde e os aspectos bioéticos da utilização dos robôs em procedimentos cirúrgicos. A cirurgia robótica é uma realidade, hoje, em muitas unidades hospitalares, o que torna essencial a reflexão bioética sobre as relações entre profissionais da saúde, autômatos e pacientes.

  7. Visual aspects of courseware engineering

    NARCIS (Netherlands)

    Lanzing, J.W.A.; Lanzing, J.W.A.; Stanchev, I.S.

    1994-01-01

    This contribution focuses on visualisation of information in courseware and in courseware engineering. An overview of advantages and disadvantages of visualisation is given, considering psychological and instructional, cross-cultural, and technical aspects of visualisation. Cross-cultural aspects

  8. THEORETICAL ASPECTS OF SCHOOL TEXTBOOK

    Directory of Open Access Journals (Sweden)

    Sveriene, Audrone

    2006-12-01

    Full Text Available School textbook is an important part of general education. Some theoretical works were written on school textbook theory. The question about textbook concept, structure and functions wasunder the dispute a long time in Lithuania and abroad.The main purpose of this article is to analyse and summarize the experience of researchers school textbook theory from Lithuania and foreign countries. The tasks of article are to determineconcept of textbook, describe the structure and the functions of the textbook. Famous scientists in this field are D. Zujev (Russia, P. Weinbrenner, F. Pingel (Germany, J. Mikk (Estonia, E. B. Johnsen (Norway, A. Choppin (France, F. M. Gerard and X. Roegiers Belgium, R. Bamberger (Austria. There are many interpretations of textbook concept, and different suggestions what is a textbook. In Lithuania the textbook concept was discussed with some specialists of Educational Development Centre and the Ministry of Education and Science. The Requirements on textbook development were approved in Lithuania only in 2003. According to the research litterature, the main aspect of the textbook is to meet the requirements of curriculum. The textbook consists of text, paratext and illustrations. All these parts of the textbook play many functions in education. The main function of the textbook is to motivate students. Other important functions of the textbook are: information, systematisation, coordination, differentiation, guidance education, learning strategy, value education, aesthetical.

  9. Geometrical aspects of quantum spaces

    International Nuclear Information System (INIS)

    Ho, P.M.

    1996-01-01

    Various geometrical aspects of quantum spaces are presented showing the possibility of building physics on quantum spaces. In the first chapter the authors give the motivations for studying noncommutative geometry and also review the definition of a Hopf algebra and some general features of the differential geometry on quantum groups and quantum planes. In Chapter 2 and Chapter 3 the noncommutative version of differential calculus, integration and complex structure are established for the quantum sphere S 1 2 and the quantum complex projective space CP q (N), on which there are quantum group symmetries that are represented nonlinearly, and are respected by all the aforementioned structures. The braiding of S q 2 and CP q (N) is also described. In Chapter 4 the quantum projective geometry over the quantum projective space CP q (N) is developed. Collinearity conditions, coplanarity conditions, intersections and anharmonic ratios is described. In Chapter 5 an algebraic formulation of Reimannian geometry on quantum spaces is presented where Riemannian metric, distance, Laplacian, connection, and curvature have their quantum counterparts. This attempt is also extended to complex manifolds. Examples include the quantum sphere, the complex quantum projective space and the two-sheeted space. The quantum group of general coordinate transformations on some quantum spaces is also given

  10. A família do p53: aspectos estruturais e funcionais do p73 e do p63 The p53 family: structural and functional aspects of p73 and p63

    Directory of Open Access Journals (Sweden)

    Alfredo Ribeiro-Silva

    2003-06-01

    Full Text Available O p53 é um gene regulador chave do ciclo celular que, quando sofre mutações, leva ao desenvolvimento de neoplasias, atuando, portanto, como um gene supressor tumoral em condições normais. Recentemente foram identificados genes homólogos ao p53 denominados p73 e p63, provavelmente oriundos de um gene ancestral comum. Apesar da grande homologia estrutural, os membros da família do p53 possuem diferenças funcionais entre si. O presente artigo tem por finalidade discorrer sobre os principais aspectos estruturais e funcionais do p73 e do p63, ressaltando seus papéis na tumorigênese humana. O p73 ativa vários genes responsivos ao p53 e, quando superexpresso, inibe a ação do p53. Raramente encontra-se mutado em neoplasias, e seu papel na tumorigênese humana ainda é motivo de controvérsias. O p63 não é um gene supressor tumoral clássico, sendo essencial para a manutenção de uma população de células precursoras (células-tronco em vários tecidos epiteliais. O p63 marca as células basais de vários órgãos epiteliais, como a pele e a próstata, podendo ser considerado um marcador de indiferenciação celular. O p63 é um marcador recentemente descrito e ainda requer maior investigação para determinar seu papel no desenvolvimento de neoplasias em humanos.The p53 gene has a key role in the cell cycle control. When mutated, it promotes the development of neoplasms, acting in so far as a tumor suppressor gene in normal conditions. Recently, genes homologue to p53 were identified, named p73 e p63, probably originated from a common ancestral gene. Despite the great structural homology, the members of p53 family have functional differences. This article aims to discourse about the major structural and functional aspects of p73 and p63, reinforcing their role in human tumorigenesis. P73 activates several p53 responsive genes and, when overexpressed, inhibits the p53 action. It is rarely mutated in neoplasms and its role in human

  11. Psychological aspects of pain.

    Science.gov (United States)

    Gorczyca, Rafał; Filip, Rafał; Walczak, Ewa

    2013-01-01

    Pain is defined "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage". Pain is a sensation of the body, and is always an unpleasant emotional experience. The role of psychology is auxiliary and supplemental to medicine. This is an aid addressed to the patient, physician and patient's caregivers: professional caregivers, family members and significant others. At each stage of the diagnostic and therapeutic process, psychology offers help, both from the cognitive and practical aspects. The objective of the article is to present important psychological aspects of studies concerning pain, and the psychological methods and techniques of pain treatment. Pain is the leading reason for patients seeking medical care and is one of the most disabling, burdensome, and costly conditions. Pain accompanies many diseases, each one of which generates unique/separate diagnostic, therapeutic and research problems. DEPRESSION AND RELATED PSYCHICAL DISORDERS: There is a significant relationship between depression and pain symptoms, as well as between pain and suicidal thoughts. Patients with a long history of pain disorders also have increased depression and anxiety symptoms, as well as suicidal thoughts. Patients with more severe depression and anxiety symptoms also have an increase in pain problems. The intensity of pain correlates with the intensity of psychopathological symptoms - both with mood lowering and with anxiety symptoms and worry. Active pain coping strategies strive to function in spite of pain, or to distract oneself from pain, are associated with adaptive functioning. Passive strategies involve withdrawal or relinquishing control to an external force or agent and are related to greater pain and depression. Pain catastrophizing is a negatively distorted perception of pain as awful, horrible and unbearable. Catastrophizing is strongly associated with depression and pain. Studies in which

  12. Electrical aspects of rainout

    International Nuclear Information System (INIS)

    Rosenkilde, C.E.

    1981-01-01

    Rainout commonly denotes the aggregate of phenomena associated with precipitation scavenging of radioactivity from a cloud of nuclear debris that is within a natural rain cloud. (In contrast, the term, washout, is applicable when the nuclear cloud is below the rain cloud and the term, fallout, commonly denotes the direct gravitational settling of contaminated solid material from a nuclear cloud.) Nuclear debris aerosols may be scavenged within natural clouds by a variety of different physical processes which may involve diffusion, convection, impaction, nucleation, phoresis, turbulence, and/or electricity among others. Processes which involve electrical aspects are scrutinized for their susceptibility to the intimate presence of the radioactive-cloud environment. This particular choice of electrical processes is not accidental. Nearly all of the listed processes were examined earlier by Williams. His rough estimates suggested that electrical effects, and to a lesser extent turbulence, could enhance the scavenging of those submicron aerosols which reside in the size-range that bridges the minimum in the scavenging rate coefficient which is commonly called the Greenfield gap. This minimum in the scavenging-rate coefficient is created by the simultaneous reduction of scavenging via diffusion and the reduction of scavenging via inertial impaction. However, Williams omitted the specific influence of a radioactive environment. This report aims to remedy this omission

  13. Epistemological risk aspects

    Directory of Open Access Journals (Sweden)

    Ardashkin I.B.

    2016-01-01

    Full Text Available The paper considers risk in the context of the main characteristics of non-classical epistemology. It states that non-classical epistemology is characterized by transformation, according to which the major priority of cognitive activity shifts the focus from the present to the past. In this situation a subject is keen not on what he or she has learnt but on what can be learnt. Truth being a crucial criterion of scientific knowledge is becoming of less priority, while risk is becoming more and more significant and acts as one of the major epistemology measurements. Risk is gaining the status of epistemological phenomenon, which shows a growing degree of uncertainty as a cognitive process background and the necessity for a subject to learn the world (make decisions under the conditions of uncertainty degree strengthening. The author states that risk is a comprehensive notion and it obtains a base value for all other aspects of its application, specifically, in the role of epistemological phenomenon.

  14. Psychiatric Aspects of Infertility

    Directory of Open Access Journals (Sweden)

    Hacer Sezgin

    2014-06-01

    Full Text Available Infertility can be defined as a crisis with cultural, religious, and class related aspects, which coexists with medical, psychiatric, psychological, and social problems. Relation between psychiatric and psychological factors stem from a mutual interaction of both. Family is an important institution in maintaining human existence and raising individuals in line with society's expectations. Fertility and reproduction are seen as universal functions unique to women with raising children as the expected result of the family institution. Incidence of infertility has increased recently and can become a life crisis for a couple. Even though not being able to have a child affects both sexes emotionally, women feel greater amounts of stress, pressure, anxiety, and depression.Consequences of infertility arise from short and long-term devastating effects on both individual's physical and mental health, and marital system. Many studies focus on infertility related psychological and psychiatric disorders (depression, anxiety, grief, marital conflict, gender differences, relation between the causes of infertility and psychopathology, the effects of psychiatric evaluation and intervention -when necessaryon the course of infertility treatment, pregnancy rates, and childbirth. The most important underlying causes of high levels of stress and anxiety that infertile women experience are the loss of maternity, reproduction, sense of self, and genetic continuity. In this review article is to investigate the relationship between medically unexplained symptoms and psychiatric symptoms. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2014; 6(2.000: 165-185

  15. Neutronic and thermalhydraulic aspects

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, J.B. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. de Mecanique et de Technologie; Bergeonneau, P. [CEA Centre d`Etudes de Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. d`Etudes des Reacteurs

    1995-12-31

    Precise computation of neutron flux in the core of a nuclear reactor represents one of the basic aspects of reactor design and operation. Neutron flux is computed by solving Boltzmann`s linear equation. Anyway, the direct solution of the equation involves too great a number of operations for practical application, leading up to TeraFlops or even PetaFlops supercomputing capabilities. Physical and mathematical models are then required to handle the extensive variety of configurations encountered. Numerical methods must be adapted to the rapid evolution of computer power, as also computer architecture: sequential, vector or parallel. Physical and mathematical models must allow for very fast estimation for online control and monitoring, adequate quantification for industrial studies and high-precision, best estimate computations. Coupling of neutronics to mechanics and two-phase flow thermohydraulics must be implemented in order to improve the accuracy in best-estimate computation schemes and to take into account the transient behaviour of the plant during normal operation or incidents. In this field of continuous improvement, the new methods applied in Reactor Physics lead obviously to good results and provide the improvements required in the future for the needs of efficiency, safety and advanced fuel cycle. This trend and the ``evolutionary`` implementation in large and modular software systems will be illustrated by the example of the SAPHYR system. (authors). 3 tabs.

  16. Futurological aspects of globalisation

    Directory of Open Access Journals (Sweden)

    Kostić Aleksandar V.

    2013-01-01

    Full Text Available The author examines futurological aspects of globalization having in mind various models of historical processes. He describes the changes as "futuroshock", thus presenting a dilemma whether the changes are only a momentum or a pre-planned concept. He especially stresses the Toffler’s conclusion that turns a new page in futurology - examining the dangers that follow the changes. According to him, predictions are made with the help of practically all the sciences in two basic directions: exploratory and normative. In his work the author considers the problem of the future not having perspective as a sequel to the present. The idea to build the world as a dualistic society of the "golden billion" and the exploited crowd is but new kind of fascism. In his opinion it is necessary to answer the question of who will indicate the qualitatively distinctive future and by which means this will be achieved. The traditional western science considers an anomaly everything that deviates a bit from it. Such a scientific paradigm projects conflicts, war, violence, which was the case in Yugoslavia, Iraq, Afghanistan, Libya, Syria etc. The author asserts three hypotheses of the possible future world order, while noticing that globalization transforms the whole regions into neo-totalitarian version of the order that spreads in concentric circles on the most of the world. According to the author, global totalitarian government is responsible for dual moral and double standards that provide limitless freedom for themselves and just the opposite for others. Within the given context, the conditions are being created on the East for a unique bloc that will consist of Chinese, Russian and Hindu-Buddhist civilization. This will serve as an alternative to the aggressive West.

  17. SOCIAL ASPECTS OF COMPETITIVENESS

    Directory of Open Access Journals (Sweden)

    Klimova A. V.

    2014-06-01

    Full Text Available One of the most important conditions of the existence of every organization, every enterprise is to insure the long-term sustainable development, one of the conditions of which is the increase of an organizational competitiveness. In modern economic conditions, social aspects of competitiveness are now in the foreground of interest, because just the strategy of social responsibility (SSR of modern enterprises can assure some commercial benefits, in responding, at the same time, to the social demands and in creating its well-being. Such an approach is in the basis of the notion of competitiveness. Along with «rigid parameters», such as price characteristics, the capability to deal with competitors, effective financial and production policies, «flexible factors» of competitiveness are of a big importance: a personnel potential, individual and collective competencies, organizational and managerial capabilities. As a result, we have formulated a research hypothesis: the organizational competitiveness is defined by individual and collective competencies of an organization, is based on socially responsible actions, confirms the demand for the object and insures its sustainable long-term development. Any organization should base all its actions aimed to increase its competitiveness on its intellectual potential, or on the management of individual and collective competencies that assure the sustainable development and the goal achievement. For every organizational strategic action, an effective combination of these competencies exists. So, we suggest a new definition of competitiveness: it is a social and economic category of understanding of the social responsibility, having as a central element individual and collective competencies, based on socially responsible actions of an enterprise, insuring its long-term sustainable development.

  18. Promoting Cognitive and Social Aspects of Inquiry through Classroom Discourse

    Science.gov (United States)

    Jin, Hui; Wei, Xin; Duan, Peiran; Guo, Yuying; Wang, Wenxia

    2016-01-01

    We investigated how Chinese physics teachers structured classroom discourse to support the cognitive and social aspects of inquiry-based science learning. Regarding the cognitive aspect, we examined to what extent the cognitive processes underlying the scientific skills and the disciplinary reasoning behind the content knowledge were taught.…

  19. Large Aspect Ratio Tokamak Study

    International Nuclear Information System (INIS)

    Reid, R.L.; Holmes, J.A.; Houlberg, W.A.; Peng, Y.K.M.; Strickler, D.J.; Brown, T.G.; Wiseman, G.W.

    1980-06-01

    The Large Aspect Ratio Tokamak Study (LARTS) at Oak Ridge National Laboratory (ORNL) investigated the potential for producing a viable longburn tokamak reactor by enhancing the volt-second capability of the ohmic heating transformer through the use of high aspect ratio designs. The plasma physics, engineering, and economic implications of high aspect ratio tokamaks were assessed in the context of extended burn operation. Using a one-dimensional transport code plasma startup and burn parameters were addressed. The pulsed electrical power requirements for the poloidal field system, which have a major impact on reactor economics, were minimized by optimizing the startup and shutdown portions of the tokamak cycle. A representative large aspect ratio tokamak with an aspect ratio of 8 was found to achieve a burn time of 3.5 h at capital cost only approx. 25% greater than that of a moderate aspect ratio design tokamak

  20. [Benzodiazepines and forensic aspects].

    Science.gov (United States)

    Michel, L; Lang, J-P

    2003-01-01

    Adverse effects of benzodiazepines are well known since the first one was used in 1958 (chlordiazepoxide). The literature collects study-cases or rarely controlled studies concerning side effects or paradoxical reactions to benzodiazepines. They mostly described drowsiness and behavioral disinhibition, including increased well-being feeling but also hostility, rage access with feeling of invulnerability, serious crimes and sometimes homicides. Delusional, manic, confusional or depressive states are also pointed out. Rate for aggressive behaviour is 0.3 to 0.7% but distinction should be done between accidental or "idiosyncratic" reaction and voluntary sought disinhibition, clearly more frequent. No benzodiazepine has any specificity for these adverse effects but pharmacology, doses, associated drugs (or alcohol) and psychopathology interact to produce hazardous psychic states. Pharmacology: GABA induces a decrease in serotonin compound and vigilance. Pharmacokinetic: first dose effect or over-dose effect, short half-life, lipophily, affinity, digestive absorption, active metabolites interact. Psychopathology: age, alcohol association, psychological status (high initial level of hostility, impulsivity, frustration, personality disorder and depressive status). External conditions: chronic illness, affective and professional frustrations, physical or psychic exhaustion contribute also. Some benzodiazepines (flunitrazepam, diazepam, clorazepate, triazolam, alprazolam, lorazepam, for example) are more often concerned for pharmacokinetics characteristics but also prescription habits. Forensic aspects should be considered in case of homicide. Especially, reality of benzodiazepines consumption and awareness of the potential paradoxical reaction should be precisely evaluated. Special focus on voluntary induced disinhibition has to be done for forensic considerations. Relationship but also crime facilitations are sometimes consciously sought. Some benzodiazepines have already

  1. General aspects of sacrococcygeal tumors

    International Nuclear Information System (INIS)

    Mosquera Betancourt, Gretel; Hernández González, Erick Héctor

    2015-01-01

    Background: tumors arising from sacrococcygeal region are weird and represent from one to seven percent of primary spinal tumors. However diagnosis and treatment are a challenge for the surgical staff because of the anatomic relations complexity and the more frequent lesions biological features. Objective: a review of the literature was done to update and systematize the knowledge about general aspects of sacrococcygeal tumors. Development: they are more frequent in male young adults, unspecific low back pain is the onset symptom and muscle weakness, sense deficit and sphincter disturbances join up later progressively. They can be epidural or intradural, primary or secondary, neoplastics or not and they could arise from soft tissues or bone structure. Age and location most be considered to evaluate malignant potential. CT scan and magnetic resonance imaging are the confirmatory tests and allow surgical approach selection. The most frequent affections are chordoma, aneurismal bone cyst and giant cell tumor. Radiotherapy and chemotherapy can support surgery according to histology. Conclusions: precocious diagnosis needs to be suspected before unspecific symptoms. Sacrococcygeal tumors treatment most be multidisciplinary and multimodal to assure better prognosis and patient´s life expectancy increasing. (author)

  2. ASPECTS OF INTEGRATION MANAGEMENT METHODS

    Directory of Open Access Journals (Sweden)

    Artemy Varshapetian

    2015-10-01

    Full Text Available For manufacturing companies to succeed in today's unstable economic environment, it is necessary to restructure the main components of its activities: designing innovative product, production using modern reconfigurable manufacturing systems, a business model that takes into account the global strategy and management methods using modern management models and tools. The first three components are discussed in numerous publications, for example, (Koren, 2010 and is therefore not considered in the article. A large number of publications devoted to the methods and tools of production management, for example (Halevi, 2007. On the basis of what was said in the article discusses the possibility of the integration of only three methods have received in recent years, the most widely used, namely: Six Sigma method - SS (George et al., 2005 and supplements its-Design for six sigm? - DFSS (Taguchi, 2003; Lean production transformed with the development to the "Lean management" and further to the "Lean thinking" - Lean (Hirano et al., 2006; Theory of Constraints, developed E.Goldratt - TOC (Dettmer, 2001. The article investigates some aspects of this integration: applications in diverse fields, positive features, changes in management structure, etc.

  3. Criminological aspects of crime recidivism

    OpenAIRE

    Lelková, Helena

    2015-01-01

    Criminological aspects of criminal recidivism The topic of this thesis are the criminological aspects of criminal recidivism and goal is to present a complete outline of some of the basic ideas related to the concept of criminal recidivism and to introduce the reader to its selected criminological aspects. This thesis is divided into four chapters. The introductory chapter is focused on the concept of criminal recidivism itself, and similarly defines the various concepts with emphasis on the ...

  4. Economic aspects of metals recover

    Science.gov (United States)

    Wieczorek, Daria; Kwaśniewska, Dobrawa

    2018-03-01

    One of the modern economy models is circular economy in which wastes should be considered as resource and used in an efficient and sustainable way. This also concerns to metals included in scraps. However, the need for metal recovery from waste is not only the result of the latest economic trends but also the result of large and constantly changing demand for metals. Shrinking natural sources of metals, concentrations of ores in small number of countries in the world and resulting from this dependence on import, geopolitical situation, new technologies demands are only a few most important determinants that have been changing the structure of the metal market over years. In this chapter, authors focused on the presentation of economic aspects of metal recovery from various sources. The chapter presents the characteristic of metal market elements (supply, demand and price) and changes that took place over decades, underlining the structure of precious and highly desirable metal market elements. Balance between the demand and supply ensures price stability and rationalizes inflation. However, growing demand on many means that secure supply chains, such as recycling and material recovery, are essential to ensure continuity in the supply chain and guarantee unrestricted technological progress and innovation. The data included in this chapter presents also the concentration of different metals and group of metals in wastes pointing that recycling of waste can become one of the possibilities of acquiring missing and critical metals. Metal-laden wastes include a few groups: waste electrical and electronic equipments, catalysts of different application, introduced on chemical, petrochemical or automotive market, galvanic wastes and wastewaters. The profitability assessment of recycling processes is very complicated. Nevertheless cited data shows that profitability of recovery depends on the metal analyzed and the type of waste. It must be underline that an optimized

  5. Thymus’ gland. Clinical, morphological and functional aspects.

    OpenAIRE

    Dunia Reyes Hernández; Mayra Gil León; Galia Ivis Pérez Rumbaut; Carmen Niurka Piña Loyola

    2004-01-01

    This article contains an updated review about the thymus making references to aspects related to its embriologic development, functions, morphology, and hormones the thymus produces and its principal effects, as well as the thymus; involution and its structural alterations, with the aim of offering enough information that allows the comprehension of the functional importance of this organ which has been considered as a non-functional organ for a long time.

  6. Business Property - tax and accounting aspects

    OpenAIRE

    ANTOŇŮ, Ivona

    2007-01-01

    In this Bachelor's thesis I have examined the issue of business assets while focusing on the aspects of taxation and book-keeping. The objective of this work is an analysis of the limits of business assets in accordance with valid Czech legislations and the application of book-keeping and taxation consequences in practical terms of changes in business assets. The theoretic section characterizes business assets in terms of physical and legal entities, the company's proprietary structure, which...

  7. GENDER ASPECTS OF MARKETING COMMUNICATIONS IN RETAIL

    OpenAIRE

    DEPUTATOVA ELENA YURYEVNA

    2016-01-01

    Situation in Russian retail demonstrates a highly competitive structure. Irrespective of segmentation ways, many retailers have still been using common ways of marketing communications and the search of loyal customers remains an elusive target for many companies. The problem is that a great variety of retailers have similar offers both to men and women, ignoring the fact it should be different. The article deals with differences of men and women consumer behavior aspects in choosing shops, t...

  8. Environmental aspects of fusion reactors 1985

    International Nuclear Information System (INIS)

    Casini, G.; Ponti, C.; Rocco, P.

    1986-01-01

    The aspects of the environmental impact as expected from future fusion reactors are reviewed. The radioactive inventories consist in tritium and neutron-induced radioactivity in the structures. An analysis is performed of the radioactive releases from the different plant's systems in normal and accident conditions and typical emissions to the ambient are defined. Information is given on the waste management problems. Two appendixes give general information on tritium and safety guidelines

  9. SOME ASPECTS REGARDING BALANCE SHEET ANALYSIS

    Directory of Open Access Journals (Sweden)

    ILIE RĂSCOLEAN

    2014-10-01

    Full Text Available This paper presents some aspects of the analysis based on the balance sheet at an economic entity. Attempting to use economic analysis as a support tool in the decision. The case study is performed on the financial accounts of a company, analyzing the structure of the assets using the following rates: the rate of intangible assets; rate of tangible assets; rate financial assets; rate stocks; rate receivables and cash and cash equivalents rate. Liability structure is analyzed using the following rates: the rate of financial stability; global financial autonomy rate; overall borrowing rate; term borrowing rate.

  10. Practical aspects of cervical cancer

    NARCIS (Netherlands)

    Tillaart, Sabrina Ada Hendrika Maria van den

    2013-01-01

    The thesis describes studies on practical aspects of cervical cancer, concering surgical considerations, and aspects of tumour behaviour and tumour spread. The thesis comprises studies on: the comparison of nerve-sparing and non-nerve-sparing radical hysterectomy for cervical cancer; a new surgical

  11. Tense and Aspect in English

    DEFF Research Database (Denmark)

    Davidsen-Nielsen, Niels

    2013-01-01

    In the 1990's the author cooperated with Carl Bache on a grammar of English. It turned out that the views they had previously arrived at individually on tense and aspect could be combined by operating with a fused system involving four ordered choices resulting in sixteen tense-aspect forms...

  12. Aspects of spirituality concerning illness

    NARCIS (Netherlands)

    van Leeuwen, Rene; Tiesinga, Lucas J.; Jochemasen, Henk; Post, Doeke

    2007-01-01

    The spiritual dimension of illness, health and care may be seen as a unique aspect in addition to the physical, mental and social dimension. This contribution describes experiences of patients, nurses and hospital chaplains in relation to the spiritual aspects of being ill. Qualitative research was

  13. Aspects of B decays

    International Nuclear Information System (INIS)

    Faller, Sven

    2011-01-01

    B-meson decays are a good probe for testing the flavour sector of the standard model of particle physics. The standard model describes at present all experimental data satisfactorily, although some ''tensions'' exist, i.e. two to three sigma deviations from the predictions, in particular in B decays. The arguments against the standard model are thus purely theoretical. These tensions between experimental data and theoretical predictions provide an extension of the standard model by new physics contributions. Within the flavour sector main theoretical uncertainties are related to the hadronic matrix elements. For exclusive semileptonic anti B → D (*) l anti ν decays QCD sum rule techniques, which are suitable for studying hadronic matrix elements, however, with substantial, but estimable hadronic uncertainties, are used. The exploration of new physics effects in B-meson decays is done in an twofold way. In exclusive semileptonic anti B → D (*) l anti ν decays the effect of additional right-handed vector as well as left- and right-handed scalar and tensor hadronic current structures in the decay rates and the form factors are studied at the non-recoil point. As a second approach one studied the non-leptonic B 0 s →J/ψφ and B 0 →J/ψK S,L decays discussing CP violating effects in the time-dependent decay amplitudes by considering new physics phase in the B 0 - anti B 0 mixing phase. (orig.)

  14. Marketing aspect of paramedical

    Directory of Open Access Journals (Sweden)

    Dugalić Sretenka L.

    2003-01-01

    Full Text Available That's how the primary medical and ecological reasons as the well being for humanity came out of the satisfaction of specific health needs. Through operationally of these outcomes it tried to prove the need and the intentions of the customers, and through methodologies and strategies which stand to our service. Further developing activity acted as a useful to the innovation of the product and vertical structure of marketing, through the change in the way of thinking of the medical and pharmaceutical profession. The paper is concepted so that the received material inserted to the content part, do the following: 1. Meaning, characteristics and developing possibilities of phytotherapy; 2. Dimensions of market in managing of phytotherapic assortment. By observing the final results, which were obtained through means of representative sources and other research of phytotherapic products, it can be expected that the same can be applicable to broader spectrum in practice with kind input to the marketing ideas. Models, presented here, is meant to be for innovative applications in the medical marketing concept, by the results of wide spending in the food service industry (domain of dietetics, at manufacture of food for children at the manufacture of 'medical cosmetics' and cosmetic-druggist assortments (products for hygiene, shampoos, soap, creams and bubbles for bath.

  15. Genetic aspects of polydactyly.

    Science.gov (United States)

    Zguricas, J; Heutink, P; Heredero, L; Deurloo, J; Oostra, B A; Snijders, P J; Lindhout, D; Hovius, S E

    1996-07-01

    The early limb development follows the similar pattern in all vertebrates since different species develop using the same regulatory genes in the formation of the body plan. Some of these genes remained well conserved during evolution and can be traced back as far as Drosophila--while some others changed their structure or developed new functions. This is why the limbs from different animals still look different from one another. However, all existing tetrapods have, like Homo Sapiens, limbs with five, or fewer digits. It has been argued that the interplay of the factors controlling the patterning and differentiation during the embryonal limb development can provide five distinct "genotypes" allowing development of only five different digits. This would imply that the Greek definition of polydactyly, namely "duplication of the finger or a part of it", is correct, not only in morphological but also in a genetical sense. Genes involved in the determination of the outline of the limb are candidates for disorders like polydactyly and syndactyly. Recently, we have localised the gene for triphalangeal thumb (TPT) on chromosome 7q. As almost 50% of our patient population also had rudimentary postaxial polydactyly and/or syndactyly, the interesting question arose whether the TPT gene also was responsible for isolated post-axial polydactyly. Our preliminary evidence suggests, however, that different gene(s) are involved in the pathomorphogenesis of postaxial polydactyly. Studies of human congenital hand malformations--combined with genetic studies in lower vertebrates--will help us to understand not only the molecular basis of these disorders, but also to get insight into the fascinating mechanisms involved in the normal development of the human hand.

  16. Aspects of B decays

    Energy Technology Data Exchange (ETDEWEB)

    Faller, Sven

    2011-03-04

    B-meson decays are a good probe for testing the flavour sector of the standard model of particle physics. The standard model describes at present all experimental data satisfactorily, although some ''tensions'' exist, i.e. two to three sigma deviations from the predictions, in particular in B decays. The arguments against the standard model are thus purely theoretical. These tensions between experimental data and theoretical predictions provide an extension of the standard model by new physics contributions. Within the flavour sector main theoretical uncertainties are related to the hadronic matrix elements. For exclusive semileptonic anti B {yields} D{sup (*)}l anti {nu} decays QCD sum rule techniques, which are suitable for studying hadronic matrix elements, however, with substantial, but estimable hadronic uncertainties, are used. The exploration of new physics effects in B-meson decays is done in an twofold way. In exclusive semileptonic anti B {yields} D{sup (*)}l anti {nu} decays the effect of additional right-handed vector as well as left- and right-handed scalar and tensor hadronic current structures in the decay rates and the form factors are studied at the non-recoil point. As a second approach one studied the non-leptonic B{sup 0}{sub s}{yields}J/{psi}{phi} and B{sup 0}{yields}J/{psi}K{sub S,L} decays discussing CP violating effects in the time-dependent decay amplitudes by considering new physics phase in the B{sup 0}- anti B{sup 0} mixing phase. (orig.)

  17. Aspect-Oriented Programming

    Science.gov (United States)

    Elrad, Tzilla (Editor); Filman, Robert E. (Editor); Bader, Atef (Editor)

    2001-01-01

    Computer science has experienced an evolution in programming languages and systems from the crude assembly and machine codes of the earliest computers through concepts such as formula translation, procedural programming, structured programming, functional programming, logic programming, and programming with abstract data types. Each of these steps in programming technology has advanced our ability to achieve clear separation of concerns at the source code level. Currently, the dominant programming paradigm is object-oriented programming - the idea that one builds a software system by decomposing a problem into objects and then writing the code of those objects. Such objects abstract together behavior and data into a single conceptual and physical entity. Object-orientation is reflected in the entire spectrum of current software development methodologies and tools - we have OO methodologies, analysis and design tools, and OO programming languages. Writing complex applications such as graphical user interfaces, operating systems, and distributed applications while maintaining comprehensible source code has been made possible with OOP. Success at developing simpler systems leads to aspirations for greater complexity. Object orientation is a clever idea, but has certain limitations. We are now seeing that many requirements do not decompose neatly into behavior centered on a single locus. Object technology has difficulty localizing concerns invoking global constraints and pandemic behaviors, appropriately segregating concerns, and applying domain-specific knowledge. Post-object programming (POP) mechanisms that look to increase the expressiveness of the OO paradigm are a fertile arena for current research. Examples of POP technologies include domain-specific languages, generative programming, generic programming, constraint languages, reflection and metaprogramming, feature-oriented development, views/viewpoints, and asynchronous message brokering. (Czarneclu and

  18. OOAspectZ and aspect-oriented UML class diagrams for Aspect-oriented software modelling (AOSM

    Directory of Open Access Journals (Sweden)

    Cristian Vidal Silva

    2013-09-01

    Full Text Available Regarding modularised software development, Aspect-oriented programming (AOP identifies and represents individually crosscutting concerns during the software development cycle’s programming stage. This article proposes and applies OOAspectZ to formal Aspect-oriented requirement specifications for prior stages of the software development cycle. It particularly concerns requirement specification and the structural design of data and behaviour, along with describing and applying Aspect-oriented UML class diagrams to designing classes, aspects and associations among classes and aspects during Aspect-oriented software development (AOSD.OOAspectZ is a language integrating both Object-Z and AspectZ formal languages whereas Aspect-oriented UML class diagrams represent AOP code, object class and crosscutting concern class structure by means of stereotypes. This article shows and applies the main OOAspectZ and AO UML class diagram characteristics to Aspect-oriented software modelling (AOSM using a classic example of AOP. Ideas for future work concerning an actual AOP version are also indicated.

  19. On Structure.

    Science.gov (United States)

    Acland, Henry

    Structure as an aspect of educational setting is discussed and illustrated in the course of an argument indicating that efforts to change schools, including Project Follow Through, should aim to change structures rather than people. It is asserted that educational reform in America usually attempts to change people, especially children, and that…

  20. STRUCTURAL MODELLING

    Directory of Open Access Journals (Sweden)

    Tea Ya. Danelyan

    2014-01-01

    Full Text Available The article states the general principles of structural modeling in aspect of the theory of systems and gives the interrelation with other types of modeling to adjust them to the main directions of modeling. Mathematical methods of structural modeling, in particular method of expert evaluations are considered.

  1. Polyurethane elastomers from morphology to mechanical aspects

    CERN Document Server

    Prisacariu, Cristina

    2011-01-01

    A comprehensive account of the physical / mechanical behaviour of polyurethanes (PU´s) elastomers, films and blends of variable crystallinity. Aspects covered include the elasticity and inelasticity of amorphous to crystalline PUs, in relation to their sensitivity to chemical and physical structure. A study is made of how aspects of the constitutive responses of PUs vary with composition: the polyaddition procedure, the hard segment, soft segment and chain extender (diols and diamines) are varied systematically in a large number of systems of model and novel crosslinked andthermoplastic PUs. Results will be related to: microstructural changes, on the basis of evidence from x-ray scattering (SAXS and WAXS), and also dynamic mechanical analyses (DMA), differential scanning calorimetry (DSC) and IR dichroism. Inelastic effects will be investigated also by including quantitative correlations between the magnitude of the Mullins effect and the fractional energy dissipation by hysteresis under cyclic straining, g...

  2. Psychological Aspects of Career Counseling.

    Science.gov (United States)

    Corbishley, M. Anne; Yost, Elizabeth B.

    1989-01-01

    Because career decision making affects all aspects of a person's life, career counseling must take into account client expectations, psychological characteristics and personality traits, nonverbal cues, and psychological variables affecting the counselor-client relationship. (SK)

  3. Administrative Aspects of Human Experimentation.

    Science.gov (United States)

    Irvine, George W.

    1992-01-01

    The following administrative aspects of scientific experimentation with human subjects are discussed: the definition of human experimentation; the distinction between experimentation and treatment; investigator responsibility; documentation; the elements and principles of informed consent; and the administrator's role in establishing and…

  4. Aspect of the conformal invariance

    International Nuclear Information System (INIS)

    Bauer, M.

    1990-11-01

    This thesis is about the study of several physical and mathematical aspects of critical phenomena at two dimensions. These phenomena have remarkable symmetry properties in the coordonnates changes keeping the angles. They are named conformal theories

  5. Physical aspects of radioisotope brachytherapy

    International Nuclear Information System (INIS)

    1967-01-01

    The present report represents an attempt to provide, within a necessarily limited compass, an authoritative guide to all important physical aspects of the use of sealed gamma sources in radiotherapy. Within the report, reference is made wherever necessary to the more extensive but scattered literature on this subject. While this report attempts to cover all the physical aspects of radioisotope 'brachytherapy' it does not, of course, deal exhaustively with any one part of the subject. 384 refs, 3 figs, 6 tabs

  6. Aspects

    Directory of Open Access Journals (Sweden)

    Fatma A. Abdel Razek

    2014-01-01

    Full Text Available The reproductive cycle of the eared horse mussel, Modiolus auriculatus, was followed for one year from February, 2011 to January, 2012 based on 240 individuals collected from Hurghada, north coast of Red Sea, Egypt. The gonadal maturation of M. auriculatus was examined by means of macroscopic and histological preparations of the mantle. Annual cycle with periods of growth, maturity and discharge of gonadic products occurs simultaneously in both sexes. Ripe individuals were observed throughout the year. The largest number of spawning for the individuals occurred from March to June and July for the population. So, it was clear to identify one heavy spawning period for this species. Sexation of M. auriculatus did not differ significantly from 1:1. Sexes were distinguishable in all individuals at the ripe stage with a shell length greater than 3.00 cm. A direct positive correlation was observed between gonad index and water temperature.

  7. [New aspects in age related macular degeneration].

    Science.gov (United States)

    Turlea, C

    2012-01-01

    Being the leading cause of blindness in modern world Age Related Macular Degeneration has beneficiated in the last decade of important progress in diagnosis, classification and the discovery of diverse factors who contribute to the etiology of this disease. Treatments have arised who can postpone the irreversible evolution of the disease and thus preserve vision. Recent findings have identified predisposing genetic factors and also inflamatory and imunological parameters that can be modified trough a good and adequate prevention and therapy This articole reviews new aspects of patology of Age Related Macular Degeneration like the role of complement in maintaining inflamation and the role of oxidative stress on different structures of the retina.

  8. Liquid-metal aspects of HYLIFE

    International Nuclear Information System (INIS)

    Meier, W.R.; Hoffman, N.J.; McDowell, M.W.

    1980-01-01

    The High Yield Lithium Injection Fusion Energy (HYLIFE) converter is a reactor concept for an inertial fusion electric power plant. In this concept, flowing molten lithium protects the structures of the fusion chamber from the deleterious effects of deuterium-tritium (DT) fusion reactions and converts the pulsed fusion energy into steay thermal power. Lithium is circulated as the primary coolant to transfer heat to an intermediate sodium loop which drives a superheated steam cycle. Lithium is also the source of the tritium fuel which is recovered via a molten-salt extraction process. The liquid-metal aspects of the HYLIFE plant with particular emphasis on the lithium systems

  9. Biomass energy utilisation - ecological and economic aspects

    International Nuclear Information System (INIS)

    Plamen Gramatikov

    2009-01-01

    Biomass is the world's fourth largest energy source today and it represents about 35% of the primary energy supply in developing countries. Biomass is a versatile source of energy in that it can produce electricity, heat, transport fuel and it can be stored. The problems (technical, economic, etc.) which have to be solved by treatment of biomass are discussed in this work. The average quantities of biomass resources of some European countries are presented and the structure, percentage of products and their calorific values are estimated. Keywords: Biomass Energy Potential, Ecological & Economic Aspects

  10. Psychosocial aspects of micturition disorders in children

    Directory of Open Access Journals (Sweden)

    S. L. Morozov

    2015-01-01

    Full Text Available The causes of psychological problems in children with micturition disorders are analyzed and social factors influencing quality of life in a child are considered. The study and understanding of the psychosocial aspects of micturition disorders in children are an important component in the structure of diagnosis and therapy of this pathology. Morbid self-perception in society contributes to further personality neurotization, social maladjustment, and emotional and neurotic disorders. The complexity is that psychological abnormalities may persist much longer even after micturition problems come to an end. The timely participation of a psychologist in patients' rehabilitation has a significant impact on the success of performed therapy.

  11. Stable Aspects in Robot Software Development

    Directory of Open Access Journals (Sweden)

    Davide Brugali

    2006-03-01

    Full Text Available The paper investigates the concept of software “stability” applied to robot systems. We define “stable” a family of systems modelled, designed and implemented so that specific applications of the family may be developed re-using, adapting and specializing knowledge, architecture and existing components. During the last few years, many ideas and technologies of software engineering (e.g. modularity, OO development and design patterns were introduced in the development of robotic systems to improve the “stability” property. All these ideas and technologies are important. Nevertheless, they model robotic systems along a unique direction: the functional decomposition of parts. Unfortunately, there are concerns of robotic systems that relate to the systems as a whole hence crosscutting their modular structure. The Aspect Oriented Software Development is a recently emerged approach for modelling, designing and encapsulating the above-mentioned crosscutting concerns (aspects. We contend that stability must be based on a careful domain analysis and on a multidimensional modelling of different and recurring aspects of robot systems.

  12. Sociocultural aspects of disorders of sex development.

    Science.gov (United States)

    Ediati, Annastasia; Maharani, Nani; Utari, Agustini

    2016-12-01

    Disorders of sex development (DSD) is a congenital condition in which the development of chromosomes, gonads, hormones, and reproductive structures are atypical. DSD brings with it a psychological impact on the affected individual and their families. The consensus statement on management of DSD strongly advised an integrated and multidisciplinary approach in providing care to the affected individuals. Studies have been conducted focusing on medical intervention, and more recently, there is increasing attention paid to psychological aspects of DSD. However, studies reporting cultural aspects of DSD are lacking. This review provides an overview on how culture impacts the affected individuals in coping with DSD and making decisions with regard to gender assignment or reassignment, help-seeking behavior for medical treatments, attitudes toward medical treatment, religious beliefs, and values concerning marriage and fertility. The involvement of social scientists is needed to study sociocultural aspects of DSD from more diverse cultures, to help affected individuals and their families in gaining better social acceptance. Birth Defects Research (Part C) 108:380-383, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  13. Assigment of environmental aspect and impacts

    Directory of Open Access Journals (Sweden)

    Hanzelová Marcela

    2001-12-01

    Full Text Available Environmental management system (EMS is a part of the management system that includes the organizational structure, planning activities, responsibilities, practices, procedures, processes and resources for developing, implementing, achieving, reviewing and maintaining the environmental policy. The EMS provides the order and consistency for organizations to adress environmental cocerns through the allocation of resources, assignment of responsibilities, and the ongoing evaluation of practices, procedures and processes. The ISO 14001 requires the implementation of the EMS in accordance with defined, internationally recognized standards. The ISO standard specifies requirements for establishing an environmental policy, determining environmental aspects & impacts of products (activities services, planning environmental objectives and measurable targets, implementation & operation of programs to meet objectives and targets, checking &corrective action, and management review. The Environmental aspect is an element of organization’s activities, product or services that can interact with the environment. A significant environmental aspect is that with a significant environmental impact. The environmental impact is any change to the environment, whether adverse or beneficial wholly or partially resulting from an oranization’s activities, products or services.

  14. [Psychological aspects of induced abortion].

    Science.gov (United States)

    Sz Makó, Hajnalka; Veszprémi, Béla

    2011-01-01

    The present paper, based on the results of international studies, is focused on the reconsideration of the psychological aspects of induced abortion. By presenting a narrow cross-section of the Hungarian demographic data, we would like to emphasise the necessity and the significance of a deeper understanding of the subject. Factors behind the decision-making, short- and long term outcomes of the intervention influencing primarily the mental health of women and partner-relationship aspects are discussed in details. While acknowledging the complexity of the subject deriving from the legal, ethical, moral, religious, medical, social and sociological concerns, our aim is to call attention to the psychological aspects of induced abortion and the importance of psychological care of women undergoing surgical operation.

  15. Separation of energy companies. Judicial aspects. Fiscal aspects of unbundling

    International Nuclear Information System (INIS)

    Slotboom, M.M.; Ter Heegde, A.

    2005-01-01

    There is much discussion in the Netherlands about the plan of the Dutch government to separate (unbundle) energy companies into a commercial energy supply business and a network business. In a series of articles attention will be paid to the legal aspects of the separation (unbundling) [nl

  16. SEMIOTIC AND COGNITIVE ASPECTS OF PROFESSIONAL DISCOURSE STUDY

    OpenAIRE

    Aznacheeva, E.N.; Mamonova, I.V.

    2017-01-01

    The article deals with the aspects of professional discourse. Linguistic aspects of professional consciousness study are disclosed; the contents of professional worldview and the structure of professional consciousness are described. Background of semiotic research of professional discourse is analyzed on the level of metalanguage and speech communication. The role of conceptual metaphor and metonymy as means of world categorization and conceptualization in professional communication is revea...

  17. Legal aspects of radiactive installations

    International Nuclear Information System (INIS)

    Malheiros, T.M.M.; Knoefell, T.M.J.

    1988-01-01

    The goal of this paper is to discuss the main legal aspects related to the application of ionizing radiation in the industry, medicine, agriculture, scientific activities to envisage from the in force legislation the competence and responsibility for the control of radiation facilities comprising regulation, licensing and inspection. Legislation does not embrace all the aspects related to radiation facilities regarding to the specific provisions on civil liability concerning damages caused by non nuclear radiological accidents. The law nr.6.453 is applied only to nuclear accident, as defined in its rules. (author) [pt

  18. Linguistic aspects of writing for professional purposes

    Directory of Open Access Journals (Sweden)

    Greta Përgjegji

    2016-03-01

    Full Text Available Writing for Professional Purposes is considered as a means of communication between professionals who belong to two communities that have different languages, but share the same knowledge or expertise. The article gives a hint on how writing for specific purposes evolved to give rise to the creation of Writing for Professional Purposes. The social, cultural and cognitive aspects are an essential part of Writing for Professional Purposes since the physical act of writing cannot be considered only a result or product of the knowledge the individual possesses but also a social and cultural act. Therefore, the social and cultural aspects of writing explains the specificities and the intricacies of the effects these aspects have on writing for it is considered as an inseparable part of social and cultural groups. On the other hand, the cognitive aspect of writing explains and emphasizes the mental activities of the individual during the decision-making process while he/she is writing planning and editing their material having in mind the audience. On the same line of reasoning, writing for professional purposes in a second language means that the writer has to consider the audience twice; first, there is an audience who shares the same knowledge or expertise and second, the audience does not have the same language. Consequently, writing in another language that is not the first language with a specific jargon as well as a specific grammatical structure brings about a lot of difficulties. Hence, writing in professional contexts in the mother tongue implies only writing in a specialized version of a language already known to the writer, but writing in a target language means that the writer has to learn the target language and the specialized version of that language.

  19. Comprehensive Aspectual UML Approach to Support AspectJ

    Directory of Open Access Journals (Sweden)

    Aws Magableh

    2014-01-01

    Full Text Available Unified Modeling Language is the most popular and widely used Object-Oriented modelling language in the IT industry. This study focuses on investigating the ability to expand UML to some extent to model crosscutting concerns (Aspects to support AspectJ. Through a comprehensive literature review, we identify and extensively examine all the available Aspect-Oriented UML modelling approaches and find that the existing Aspect-Oriented Design Modelling approaches using UML cannot be considered to provide a framework for a comprehensive Aspectual UML modelling approach and also that there is a lack of adequate Aspect-Oriented tool support. This study also proposes a set of Aspectual UML semantic rules and attempts to generate AspectJ pseudocode from UML diagrams. The proposed Aspectual UML modelling approach is formally evaluated using a focus group to test six hypotheses regarding performance; a “good design” criteria-based evaluation to assess the quality of the design; and an AspectJ-based evaluation as a reference measurement-based evaluation. The results of the focus group evaluation confirm all the hypotheses put forward regarding the proposed approach. The proposed approach provides a comprehensive set of Aspectual UML structural and behavioral diagrams, which are designed and implemented based on a comprehensive and detailed set of AspectJ programming constructs.

  20. Comprehensive Aspectual UML approach to support AspectJ.

    Science.gov (United States)

    Magableh, Aws; Shukur, Zarina; Ali, Noorazean Mohd

    2014-01-01

    Unified Modeling Language is the most popular and widely used Object-Oriented modelling language in the IT industry. This study focuses on investigating the ability to expand UML to some extent to model crosscutting concerns (Aspects) to support AspectJ. Through a comprehensive literature review, we identify and extensively examine all the available Aspect-Oriented UML modelling approaches and find that the existing Aspect-Oriented Design Modelling approaches using UML cannot be considered to provide a framework for a comprehensive Aspectual UML modelling approach and also that there is a lack of adequate Aspect-Oriented tool support. This study also proposes a set of Aspectual UML semantic rules and attempts to generate AspectJ pseudocode from UML diagrams. The proposed Aspectual UML modelling approach is formally evaluated using a focus group to test six hypotheses regarding performance; a "good design" criteria-based evaluation to assess the quality of the design; and an AspectJ-based evaluation as a reference measurement-based evaluation. The results of the focus group evaluation confirm all the hypotheses put forward regarding the proposed approach. The proposed approach provides a comprehensive set of Aspectual UML structural and behavioral diagrams, which are designed and implemented based on a comprehensive and detailed set of AspectJ programming constructs.

  1. Comprehensive Aspectual UML Approach to Support AspectJ

    Science.gov (United States)

    Magableh, Aws; Shukur, Zarina; Mohd. Ali, Noorazean

    2014-01-01

    Unified Modeling Language is the most popular and widely used Object-Oriented modelling language in the IT industry. This study focuses on investigating the ability to expand UML to some extent to model crosscutting concerns (Aspects) to support AspectJ. Through a comprehensive literature review, we identify and extensively examine all the available Aspect-Oriented UML modelling approaches and find that the existing Aspect-Oriented Design Modelling approaches using UML cannot be considered to provide a framework for a comprehensive Aspectual UML modelling approach and also that there is a lack of adequate Aspect-Oriented tool support. This study also proposes a set of Aspectual UML semantic rules and attempts to generate AspectJ pseudocode from UML diagrams. The proposed Aspectual UML modelling approach is formally evaluated using a focus group to test six hypotheses regarding performance; a “good design” criteria-based evaluation to assess the quality of the design; and an AspectJ-based evaluation as a reference measurement-based evaluation. The results of the focus group evaluation confirm all the hypotheses put forward regarding the proposed approach. The proposed approach provides a comprehensive set of Aspectual UML structural and behavioral diagrams, which are designed and implemented based on a comprehensive and detailed set of AspectJ programming constructs. PMID:25136656

  2. An approach for the assessment of the statistical aspects of the SEA coupling loss factors and the vibrational energy transmission in complex aircraft structures: Experimental investigation and methods benchmark

    Science.gov (United States)

    Bouhaj, M.; von Estorff, O.; Peiffer, A.

    2017-09-01

    In the application of Statistical Energy Analysis "SEA" to complex assembled structures, a purely predictive model often exhibits errors. These errors are mainly due to a lack of accurate modelling of the power transmission mechanism described through the Coupling Loss Factors (CLF). Experimental SEA (ESEA) is practically used by the automotive and aerospace industry to verify and update the model or to derive the CLFs for use in an SEA predictive model when analytical estimates cannot be made. This work is particularly motivated by the lack of procedures that allow an estimate to be made of the variance and confidence intervals of the statistical quantities when using the ESEA technique. The aim of this paper is to introduce procedures enabling a statistical description of measured power input, vibration energies and the derived SEA parameters. Particular emphasis is placed on the identification of structural CLFs of complex built-up structures comparing different methods. By adopting a Stochastic Energy Model (SEM), the ensemble average in ESEA is also addressed. For this purpose, expressions are obtained to randomly perturb the energy matrix elements and generate individual samples for the Monte Carlo (MC) technique applied to derive the ensemble averaged CLF. From results of ESEA tests conducted on an aircraft fuselage section, the SEM approach provides a better performance of estimated CLFs compared to classical matrix inversion methods. The expected range of CLF values and the synthesized energy are used as quality criteria of the matrix inversion, allowing to assess critical SEA subsystems, which might require a more refined statistical description of the excitation and the response fields. Moreover, the impact of the variance of the normalized vibration energy on uncertainty of the derived CLFs is outlined.

  3. Resonant inelastic x-ray scattering on iso-C{sub 2}H{sub 2}Cl{sub 2} around the chlorine K-edge: Structural and dynamical aspects

    Energy Technology Data Exchange (ETDEWEB)

    Kawerk, Elie, E-mail: eliekawerk@hotmail.com, E-mail: ekawerk@units.it [CNRS, UMR 7614, Laboratoire de Chimie Physique-Matière et Rayonnement, F-75005 Paris (France); Sorbonne Universités, UPMC Université Paris 06, UMR 7614, Laboratoire de Chimie Physique-Matière et Rayonnement, F-75005 Paris (France); Laboratoire de Physique Appliquée, Faculté des Sciences II, Université Libanaise, 90656 Jdeidet el Metn, Liban (Libya); Dipartimento di Scienze Chimiche, Università di Trieste, Via L. Giorgieri 1, I-34127 Trieste (Italy); Carniato, Stéphane; Journel, Loïc; Marchenko, Tatiana; Simon, Marc [CNRS, UMR 7614, Laboratoire de Chimie Physique-Matière et Rayonnement, F-75005 Paris (France); Sorbonne Universités, UPMC Université Paris 06, UMR 7614, Laboratoire de Chimie Physique-Matière et Rayonnement, F-75005 Paris (France); Piancastelli, Maria Novella [CNRS, UMR 7614, Laboratoire de Chimie Physique-Matière et Rayonnement, F-75005 Paris (France); Sorbonne Universités, UPMC Université Paris 06, UMR 7614, Laboratoire de Chimie Physique-Matière et Rayonnement, F-75005 Paris (France); Department of Physics and Astronomy, Uppsala University, P.O. Box 516, SE-751 20 Uppsala (Sweden); Žitnik, Matjaž; Bučar, Klemen; Bohnic, Rok [Jožef Stefan Institute, Jamova cesta 39, SI-1000 Ljubljana (Slovenia); and others

    2014-10-14

    We report a theoretical and experimental study of the high resolution resonant K{sub α} X-ray emission lines around the chlorine K-edge in gas phase 1,1-dichloroethylene. With the help of ab initio electronic structure calculations and cross section evaluation, we interpret the lowest lying peak in the X-ray absorption and emission spectra. The behavior of the K{sub α} emission lines with respect to frequency detuning highlights the existence of femtosecond nuclear dynamics on the dissociative Potential Energy Surface of the first K-shell core-excited state.

  4. Fundamental aspects of nuclear reactor fuel elements

    International Nuclear Information System (INIS)

    Olander, D.R.

    1976-01-01

    The book presented is designed to function both as a text for first-year graduate courses in nuclear materials and as a reference for workers involved in the materials design and performance aspects of nuclear power plants. The contents are arranged under the following chapter headings: statistical thermodynamics, thermal properties of solids, crystal structures, cohesive energy of solids, chemical equilibrium, point defects in solids, diffusion in solids, dislocations and grain boundaries, equation of state of UO 2 , fuel element thermal performance, fuel chemistry, behavior of solid fission products in oxide fuel elements, swelling due to fission gases, pore migration and fuel restructuring kinetics, fission gas release, mechanical properties of UO 2 , radiation damage, radiation effects in metals, interaction of sodium and stainless steel, modeling of the structural behavior of fuel elements and assemblies

  5. International aspects of nuclear installations licensing

    International Nuclear Information System (INIS)

    Kunth, B.

    1987-01-01

    International collaboration, eg on the Superphenix and SNR 300 fast breeder reactors, is seen as a good thing. However, the question is asked whether the collaboration extends to the licensing procedure. Is this the reason why in some countries nuclear programmes flourish, whereas in others there are delays? The structure of the licensing procedures in the United Kingdom, France and West Germany is compared. The different licensing procedures only have a limited effect on the outcome of the fast breeder programme. The differences lie in the centralised or federal government structure and different socio-political aspects. However, these are reflected in licensing procedures. Means of international collaboration within the licensing framework are suggested, but may be difficult to achieve yet. A major step forward would be to develop uniform safety standards for the licensing procedure and to make sure each country complies with them. (U.K.)

  6. Fundamental aspects of nuclear reactor fuel elements

    Energy Technology Data Exchange (ETDEWEB)

    Olander, D.R.

    1976-01-01

    The book presented is designed to function both as a text for first-year graduate courses in nuclear materials and as a reference for workers involved in the materials design and performance aspects of nuclear power plants. The contents are arranged under the following chapter headings: statistical thermodynamics, thermal properties of solids, crystal structures, cohesive energy of solids, chemical equilibrium, point defects in solids, diffusion in solids, dislocations and grain boundaries, equation of state of UO/sub 2/, fuel element thermal performance, fuel chemistry, behavior of solid fission products in oxide fuel elements, swelling due to fission gases, pore migration and fuel restructuring kinetics, fission gas release, mechanical properties of UO/sub 2/, radiation damage, radiation effects in metals, interaction of sodium and stainless steel, modeling of the structural behavior of fuel elements and assemblies. (DG)

  7. Institutional and socioeconomic aspects of water supply

    Science.gov (United States)

    Rauchenschwandtner, H.; Pachel, M.

    2012-04-01

    Institutional and socioeconomic aspects of water supply Within the project CC-WaterS the participating researchers of the Vienna University of Economics and B.A. have been responsible for the analysis of the socioeconomic aspects related to water supply and climate change, the assessment of future water demands in the City of Vienna, as well as an estimation of economic consequences of possible water shortages and possible scope for the introduction of new legal guidelines. The institutional and socioeconomic dimensions of drinking water and sanitation systems are being examined by utilisation of different prognostic scenarios in order to assess future costs of water provisioning and future demands of main water users, thus providing an information basis and recommendations for policy and decision makers in the water sector. These dimensions, for example, include EU legislation - especially the Water Framework Directive -, national legislations and strategies targeted at achieving sustainability in water usage, best practices and different forms of regulating water markets, and an analysis of the implications of demographic change. As a basis this task encompasses research of given institutional, social, and legal-political structures in the area of water supply. In this course we provide an analysis of the structural characteristics of water markets, the role of water prices, the increasing perception of water as an economic good as well as implications thereof, the public awareness in regard to climate change and water resources, as well as related legal aspects and involved actors from regional to international level; and show how water resources and the different systems of water provisioning are affected by (ideological) conflicts on various levels. Furthermore, and in order to provide a solid basis for management recommendations related to climate change and water supply, an analytical risk-assessment framework based on the concepts of new institutional

  8. Tumeurs mandibulaires : Aspects epidemiologiques et ...

    African Journals Online (AJOL)

    Tumeurs mandibulaires : Aspects epidemiologiques et anatomopathologiques(a propos de 180 cas colliges au laboratoire d'anatomie pathologique du Chu de Lome) ... Results: The tumors of the mandible represented in our study 16.90% of the ORL tumors. The women with 50.56%, were more hit than the men.

  9. Mathematical Aspects of Electoral Systems

    Science.gov (United States)

    Konstantinov, M. M.

    2007-10-01

    In this paper we consider some mathematical aspects of electoral systems. Sometimes the results from elections seem paradoxical although they are mathematically correct. These cases are known as electoral paradoxes. A number of paradoxes of proportional and majoritarian electoral systems are considered.

  10. Gender Aspects of Human Security

    Science.gov (United States)

    Moussa, Ghada

    2008-01-01

    The chapter deals with the gender dimensions in human security through focusing on the relationship between gender and human security, first manifested in international declarations and conventions, and subsequently evolving in world women conferences. It aims at analysing the various gender aspects in its relation to different human security…

  11. Aspects of human chlamydial infections

    NARCIS (Netherlands)

    K.H. Tjiam

    1987-01-01

    textabstractThis thesis takes a closer look at three aspects of human chlamydial infections. With regard to diagnosis the influence of logistics on the sensitivity of the culture method is discussed, along with optimalization of the culture itself and an evaluation of new diagnostic methods.

  12. Computational Aspects of Asynchronous CA

    OpenAIRE

    Chandesris, Jérôme; Dennunzio, Alberto; Formenti, Enrico; Manzoni, Luca

    2011-01-01

    This work studies some aspects of the computational power of fully asynchronous cellular automata (ACA). We deal with some notions of simulation between ACA and Turing Machines. In particular, we characterize the updating sequences specifying which are "universal", i.e., allowing a (specific family of) ACA to simulate any TM on any input. We also consider the computational cost of such simulations.

  13. Social aspects of nuclear power

    International Nuclear Information System (INIS)

    Koryakin, Yu.I.

    1990-01-01

    Social aspects of nuclear power crisis in the USSR are considered. It is shown that the system of economic and social stimulation and different compensations widely used abroad when locating nuclear power plants, is the effective factor, providing loyal attitude to them

  14. Verbal aspects in West Greenlandic

    DEFF Research Database (Denmark)

    Trondhjem, Naja Blytmann

    2017-01-01

    In this article, lexical aspectual types in West Greenlandic are investigated in the five aspectual types, states, achievements, semelfactives, activities and accomplishments. It is shown that derivational verbalizing affixes include aspectual type congruent with the lexical aspect and how the as...

  15. Aspect Composition using Composition Filters

    NARCIS (Netherlands)

    Bergmans, Lodewijk; Aksit, Mehmet; Tekinerdogan, B.; Aksit, Mehmet

    2002-01-01

    This chapter first discusses a number of software reuse and extension problems in current object-oriented languages. For this purpose, a change case for a simplified mail system is presented. Each evolution step in the change case consists of the addition or refinement of certain aspects to existing

  16. Scientific aspects of radiation protection

    International Nuclear Information System (INIS)

    Anon.

    1983-01-01

    A brief review is given of the basic radiation physics background knowledge required to aid the understanding of the scientific aspects of radiation protection. The different types of electromagnetic and particulate radiation are described together with general information on ray energy, radioactivity units and radionuclide half-life. (U.K.)

  17. Probabilistic aspects of ocean waves

    NARCIS (Netherlands)

    Battjes, J.A.

    1977-01-01

    Background material for a special lecture on probabilistic aspects of ocean waves for a seminar in Trondheim. It describes long term statistics and short term statistics. Statistical distributions of waves, directional spectra and frequency spectra. Sea state parameters, response peaks, encounter

  18. Crimean Referendum: International Legal Aspects

    Directory of Open Access Journals (Sweden)

    Michael Geistlinger

    2014-12-01

    Full Text Available The article examines the key aspects of the accession of the Republic of Crimea to the Russian Federation as the example of enforcement of the people’s right to self-determination, secured in UN Charter. International law basis of the accession, as well analysis of key reasons and consequences of this international precedent are under consideration.

  19. Physiological aspects of paired stimulation

    NARCIS (Netherlands)

    Meijler, F.L.; Durrer, D.

    1965-01-01

    In this paper some physiological and clinical aspects of paired stimulation are discussed. I) The augmenting effect of paired stimulation on rnyocardial contractility is due to potentiation (increase in speed of restitution) and fusion of two contractions. 2) While using paired stimulation the

  20. Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold

    DEFF Research Database (Denmark)

    Nørholm, Ann-Beth; Francotte, Pierre; Olsen, Lars

    2013-01-01

    receptor desensitization and/or deactivation. Here we describe the synthesis and pharmacological testing at GluA2 of a new generation of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides. The most potent modulator 3 in complex with GluA2-LBD-L483Y-N754S was subjected to structural analysis by X......-ray crystallography, and the thermodynamics of binding was studied by isothermal titration calorimetry. Compound 3 binds to GluA2-LBD-L483Y-N754S with a Kd of 0.35 μM (ΔH = -7.5 kcal/mol and -TΔS = -1.3 kcal/mol). This is the first time that submicromolar binding affinity has been achieved for this type of positive...

  1. The unperturbed oxo-sulfido functional group cis-Mo{sup VI}OS related to that in the xanthine oxidase family of molybdoenzymes: Synthesis, structural characterization, and reactivity aspects

    Energy Technology Data Exchange (ETDEWEB)

    Thapper, A.; Donahue, J.P.; Musgrave, K.B.; Willer, M.W.; Nordlander, E.; Hedman, B.; Hodgson, K.O.; Holm, R.H.

    1999-09-06

    The oxo-sulfido functional group cis-Mo{sup VI}OS is essential to the activity of the xanthine oxidase family of enzymes but has proven elusive to synthesis in molecules containing no other four-electron ligands. A direct route to molecules containing this group has been achieved. The reaction system [MoO{sub 2}(OSiPh{sub 3}){sub 2}]/L in dichloromethane yields the complexes [Mo{sup VI}O{sub 2}(OSiPh{sub 3}){sub 2}L] (L = phen (1), Me{sub 4}phen (2), 4,4{prime}-Me{sub 2}bpy (3), 5,5{prime}-Me{sub 2}bpy (4), 2 py (5)) (74--96%), which are shown to have a distorted octahedral structure of crystallographically imposed C{sub 2} symmetry (1, 5) with cis oxo and trans silyloxy ligands. The related reaction system [MoO{sub 3}S]{sup 2{minus}}/2Ph{sub 3}SiCl/L in acetonitrile affords the complexes [Mo{sup VI}OS(OSiPh{sub 3}){sub 2}L] (L = phen (6), Me{sub 4}phen (7), 4,4{prime}-Me{sub 2}bpy (8), 5,5{prime}-Me{sub 2}bpy (9)) (36--69%). From the collective results of elemental analysis, mass spectrometry, {sup 1}H NMR, and X-ray structure determinations (6, 7), complexes 6--9 are shown to contain the cis-Mo {sup VI}OS group in molecules with the same overall stereochemistry as dioxo complexes 1--5. The crystal structures of 6 and 7 exhibit O/S disorder, which was modeled in refinements with 50% site occupancies. The Mo{double{underscore}bond}O (1.607(5) (6), 1.645(5) (7) {angstrom}) and Mo{double{underscore}bond}S (2.257(3) (6), 2.203(2) (7) {angstrom}) bond distances obtained in this way are somewhat shorter and longer, respectively, than expected. Distances obtained by molybdenum EXAFS analysis using the GNXAS protocol for 6--9 (Mo{double{underscore}bond}O 1.71--1.72 {angstrom}; Mo{double{underscore}bond}S 2.18--2.19 {angstrom}) are considered more satisfactory and are in good agreement with EXAFS values for xanthine oxidase. Molybdenum K-edge data for 1 and 6--9 are reported. Reaction of 7 with Ph{sub 3}P in dichloromethane results in sulfur abstraction and formation of

  2. Structural and thermodynamic aspects of aqueous solution of trivalent lanthanides complexation by hydrophobic compounds of tartaric acid, by gluconic acid and related molecules. Outlook for liquid-liquid extraction of these cations

    International Nuclear Information System (INIS)

    Giroux, Sebastien

    1999-01-01

    This work deals with the complexation of lanthanide(III) ions by different molecules and with the synthesis of hydrophobic molecules able to extract them of an aqueous solution. Its aim is to describe the systems obtained by the determination of the formation constants of the species and by the description of their structure. The aim of this work is also to obtain a selective complexation of lanthanides(III) towards actinides(III), because this aim presents a great interest in the reprocessing of radioactive wastes. The complexation studies have been followed by potentiometry, NMR, UV-visible spectroscopy and circular dichroism. The first mixtures studied are the couples: lanthanide(III)-gluconic acid (LH). The complexes system they formed has been described and the structures have been specified; a strong complexation has been revealed. The MLH -2 specie induces a selectivity between the lanthanides(III) equivalent to those obtained with EDTA and its uncharged character allows to consider the use of gluconic acid as extractant. The use of ligands as glucosaminic acid or glucamine slows the beginning of the complexation until pH= 6-7. The neutral specie MLH -2 is formed too. In order to use the complexing properties of gluconic acid and its selective character towards lanthanides(III), the synthesis of molecules derived containing a long alkyl chain with a hydrophobic character has been carried out for using them as extracting agents. An original method of the preparation of tartramides is presented. This preparation consists of an amidation of one of the carboxylic functions of the tartaric acid by a fatty amine. These molecules, surface-active, complex the lanthanides(III) and extract them in an organic phase using the tri-n-butyl phosphate as co-extractant. (O.M.)

  3. Complex strain paths in polycrystalline copper: microstructural aspects

    Directory of Open Access Journals (Sweden)

    M.F. Vieira

    1999-07-01

    Full Text Available Microstructural aspects of polycrystalline copper sheets subjected to complex strain paths were analysed in this work. Dislocation structures developed during the strain paths (rolling and tension and the evolution of this microstructure during reloading have been studied. The active slip systems developed in each strain path were used to explain the microstructural evolution. The heterogeneous surface deformation observed on polished tensile specimens prestrained in rolling was also analysed. The structural aspects are related with the mechanical behaviour of the material, namely with the increase in yield stress in reloading, the work hardening evolution and the premature occurrence of plastic instability for some prestrain values.

  4. Selected aspects of fusion reactions

    International Nuclear Information System (INIS)

    Lacroix, D.

    2003-01-01

    In this lecture, we present selected aspects of nuclear fusion. The importance of the initial geometry of the reaction and its relation to fusion barrier are first discussed. The effect of deformation leading to the notion of barrier distribution is then illustrated. After a brief overview of the advantages of macroscopic theories, the dynamics of nuclear system under large amplitude motion is reviewed. The di-nuclear concept is presented to understand the competition between fusion and quasi-fission. This concept is then generalized to account for the dissipative dynamics in multidimensional collective space. The last part of this lecture is devoted to new aspects encountered with radioactive beams specific properties of very extended neutron rich system, influence of pygmy or soft dipole resonances and charge exchange far from stability are discussed. (author)

  5. Ethical aspect price decision making

    Directory of Open Access Journals (Sweden)

    Grubor Aleksandar

    2007-01-01

    Full Text Available Price decision making in a marketing program framework creatings is a complicated and delicated part of marketing management, especially to keep in sight culminating of mass external factors. In a market economies price policy as a marketing mix instrument rarely is regulated by the law, which opening the ethical aspect questions of price decision making process. The ethics in the price decision making means consideration of the inner law of the individual (marketing managers and/or consumers, whose irreverence does not entail any juridical sanctions, rather its application is sanctioned by the self - awareness. The acception and stability of the ethical aspect price decision making are determined by the characteristic of selected marketing environment.

  6. The psychological aspects of rhinoplasty.

    Science.gov (United States)

    Tasman, Abel-Jan

    2010-08-01

    Literature on the psychological aspects of rhinoplasty is sparse compared with publications on methods and instrumentation. Understanding the psychological aspects of rhinoplasty and, more importantly, recognizing the patient who may have an unfavorable postoperative course regardless of the objective outcome is of fundamental importance to the surgeon. Several profiles of patients with a high risk of postoperative dissatisfaction have been described and the important role of body dysmorphic disorder and its treatment has been stressed. Still, these criteria can be insufficient when facing the individual patient, as reliable screening instruments for clinical practice have not been developed and the question when not to operate is subject to controversy. The role of computer imaging as a safeguard in preoperative counseling has been highlighted. The surgeon must rely on instinct and experience to avoid overlooking any signs of psychological imbalance in the patient that may herald adversity. Archetypes described in the literature should be recognized and computer imaging should be used during the preoperative consultation.

  7. New aspects of canine pyometra

    OpenAIRE

    Hagman, Ragnvi

    2004-01-01

    Pyometra is a common and lethal disease in bitches characterised by uterine bacterial infection leading to subsequent systemic illness. The objectives of the present thesis were to investigate the incidence of the disease in relation to breed and age, to assess bacteriological aspects of pyometra and to evaluate the involvement of endotoxin and prostaglandin F2α in the pathogenesis. Animal insurance data revealed age- and breed-dependent differences in the incidence of pyometra. On average 23...

  8. GLOBAL WARMING AND CONSTRUCTION ASPECTS

    OpenAIRE

    Bassioni, Ghada

    2015-01-01

    The manufacture of cements with several main constituents is of particular importance with regard to reducing climatically relevant CO2 emissions in the cement industry. This ecological aspect is not the only argument in favor of Portland composite cements. They are also viable alternatives to Portland cement from the technical point of view. Substitution of ordinary Portland cement (CEM I) by Portland composite cements (CEM II) and (CEM III), which clearly possess different chemical and mine...

  9. Aspects echocardiographiques et etiologiques des ...

    African Journals Online (AJOL)

    Buts: Décrire les aspects échocardiographiques et étiologiques des cardiomyopathies chez le noir africain. Patients et méthodes: Il s'est agit d'une étude prospective réalisée à la clinique cardiologique du CHUCampus de Lomé du 1er janvier 2007 au 31 décembre 2009. Etaient inclus dans l'étude, les patients consultants ...

  10. Psychiatric Aspects of Childhood Epilepsy

    OpenAIRE

    Raman Deep PATTANAYAK; Rajesh SAGAR

    2012-01-01

    How to Cite this Article: Pattanayak RD, Sagar R. Psychiatric Aspects of Childhood Epilepsy. Iran J Child Neurol 2012;6(2):9-18.Childhood epilepsy is a chronic, recurrent disorder of unprovoked seizures. Theonset of epilepsy in childhood has significant implications for brain growth anddevelopment. Seizures may impair the ongoing neurodevelopmental processes and compromise the child’s intellectual and cognitive functioning, leading totremendous cognitive, behavioral and psychosocial consequen...

  11. Medical aspects of radiation accidents

    International Nuclear Information System (INIS)

    Messerschmidt, O.

    1990-01-01

    Reactor accidents and nuclear bomb explosions are compared including the release of radioactivity in an accident, results of risk studies, emergency measures of nuclear power plants, and evacuation of the population. The medical aspects refer to the prophylaxies of the thyroid gland, contamination and decontamination of body surfaces, recommendations of the ICRP, radiation injury after total body exposure and medical problems after a reactor accident. (DG)

  12. Ethical aspect price decision making

    OpenAIRE

    Grubor Aleksandar

    2007-01-01

    Price decision making in a marketing program framework creatings is a complicated and delicated part of marketing management, especially to keep in sight culminating of mass external factors. In a market economies price policy as a marketing mix instrument rarely is regulated by the law, which opening the ethical aspect questions of price decision making process. The ethics in the price decision making means consideration of the inner law of the individual (marketing managers and/or consumers...

  13. Human - computer interaction: communication aspects

    OpenAIRE

    Burauskas, Gytis

    2009-01-01

    The subject of this work is communication of human-computer interaction. The objective is to analyze the human-computer interaction from the communication perspective. The main goals are: to review and analyze the conception and evolution of human-computer interaction, to find out the application possibilities of human-computer interaction in communication field; to analyze the process of human-computer interaction design, its characteristics and communication aspects; to formulate and argue ...

  14. Economic aspects of enegy policies

    International Nuclear Information System (INIS)

    Lattes, Robert; Thiriet, Lucien

    1979-01-01

    In analysing more particularly the case of France, the authors show how an appropriate energy policy may be an instrument in the fight against inflation and how it may, in particular through development of nuclear energy, ensure the compatibility which is sough after among growth, employment and external balance. Also to be appreciated is the exent to which energy policies are constantly increasing their importance as an essential aspect of economic, monetary and social policy [fr

  15. Some global aspects regarding nuclear spent fuel management

    International Nuclear Information System (INIS)

    Ohai, Dumitru; Postoaca, Marius Marcel

    2002-01-01

    The globalization means the worldwide extension of certain aspects of social or economic processes, structural or environmental changes, or concerning working methodologies, technical activity, industrial production, etc. At present the emergence of global aspects is more frequently observed, being determined by the rapid development of computerized systems and of transfer of information, by the development of big transnational companies and due to the increasing international co-operation. Some of the manifested global aspects could be beneficial for the development of the human society, other could be not. It is necessary to perform an adequate analysis from this view point and to promote appropriate measures to enhance the positive global aspects and to mitigate the negative global aspects. These measures can have a good efficiency only if they are pursued at global level, but for this it is necessary to build an adequate international coordinating body, having the corresponding instruments for action. The global aspects identified in the field of nuclear power may be divided into two categories, namely: - related to the main features of nuclear power; - regarding the specific features of some subdivisions of the field, as for example, spent fuel management. In the paper both categories are discussed. The influence of the global aspects on the development of nuclear power and particularly on the back end activities of the fuel cycle, is also presented. At the same time, some possible actions for enhancing nuclear power development are proposed

  16. ABOUT SOLUTION OF MULTIPOINT BOUNDARY PROBLEMS OF TWO-DIMENSIONAL STRUCTURAL ANALYSIS WITH THE USE OF COMBINED APPLICATION OF FINITE ELEMENT METHOD AND DISCRETE-CONTINUAL FINITE ELEMENT METHOD PART 2: SPECIAL ASPECTS OF FINITE ELEMENT APPROXIMATION

    Directory of Open Access Journals (Sweden)

    Pavel A. Akimov

    2017-12-01

    Full Text Available As is well known, the formulation of a multipoint boundary problem involves three main components: a description of the domain occupied by the structure and the corresponding subdomains; description of the conditions inside the domain and inside the corresponding subdomains, the description of the conditions on the boundary of the domain, conditions on the boundaries between subdomains. This paper is a continuation of another work published earlier, in which the formulation and general principles of the approximation of the multipoint boundary problem of a static analysis of deep beam on the basis of the joint application of the finite element method and the discrete-continual finite element method were considered. It should be noted that the approximation within the fragments of a domain that have regular physical-geometric parameters along one of the directions is expedient to be carried out on the basis of the discrete-continual finite element method (DCFEM, and for the approximation of all other fragments it is necessary to use the standard finite element method (FEM. In the present publication, the formulas for the computing of displacements partial derivatives of displacements, strains and stresses within the finite element model (both within the finite element and the corresponding nodal values (with the use of averaging are presented. Boundary conditions between subdomains (respectively, discrete models and discrete-continual models and typical conditions such as “hinged support”, “free edge”, “perfect contact” (twelve basic (basic variants are available are under consideration as well. Governing formulas for computing of elements of the corresponding matrices of coefficients and vectors of the right-hand sides are given for each variant. All formulas are fully adapted for algorithmic implementation.

  17. The structural and energetic aspects of substrate binding and the mechanism of action of the DapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) investigated using a hybrid QM/MM method.

    Science.gov (United States)

    Dutta, Debodyuti; Mishra, Sabyashachi

    2014-12-21

    With increasing cases of fatal bacterial infections and growing antibiotic resistance, unrelenting efforts are necessary for identification of novel antibiotic targets and new drug molecules. The dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) is a di-nuclear Zn containing enzyme in the lysine biosynthetic pathway which is indispensable for bacterial survival and absent in the human host, thus a potential antibiotic target. The DapE enzyme catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP) to give rise to succinic acid and L,L-diaminopimelic acid. The mechanism of action of the DapE catalyzed SDAP hydrolysis is investigated employing a hybrid QM/MM computational method. The DapE side chains, such as, Arg178, Thr325, Asn345, are found to play a role in substrate identification and stabilization of the enzyme active site. Furthermore, a glycine rich loop (Gly322-Ser326) is found to facilitate tight binding of the substrate in the enzyme active site. The catalytic reaction progresses via a general acid-base hydrolysis mechanism where Glu134 first acts as a Lewis base by activating the catalytic water molecule in the active site, followed by guiding the resulting hydroxyl ion for a nucleophilic attack on the substrate, and finally acts as a Lewis acid by donating a proton to the substrate. The intermediates and transition states along the reaction pathway have been structurally and energetically characterized. A conformational change in the side chain of Asp100, which bridges the two Zn centers of the enzyme, is observed which facilitates the enzymatic action by lowering the activation energy and leads to the formation of a new intermediate during the catalytic reaction. The nucleophilic attack is found to be the rate determining step.

  18. Structural Aspects of Flexible Aircraft Control (les Aspects structuraux du controle actif et flexible des aeronefs)

    Science.gov (United States)

    2000-05-01

    Inc. Canadair Dr. E. SANCHIZ Military Aircraft Division Div. de Estructuras y Materiales 10,000 Cargo A-4 Street Laboratorio de Diseno y Analisis...Dynamics and Aeroelasticity Department CONSTRUCCIONES AERONAUTICAS S.A. Avda John Lennon Getafe, 28906 Madrid, Spain Summary Nomenclature for modal

  19. Aspectos estruturais e funcionais do apoio social de idosos do Município de São Paulo, Brasil Structural and functional aspects of social support for the elderly in the city of São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Tereza Etsuko da Costa Rosa

    2007-12-01

    Full Text Available Este trabalho teve como objetivo descrever a distribuição das redes sociais e de apoio em idosos no Município de São Paulo, Brasil, por características sócio-econômicas e demográficas. Estudou-se amostra probabilística de 1.568 idosos (60 ou mais anos da cidade de São Paulo (inquérito sobre Saúde, Bem-estar e Envelhecimento - SABE, focalizando-se as dimensões estruturais e funcionais das redes sociais. Para a análise dos dados utilizou-se a regressão logística simples e múltipla. As melhores condições nas redes sociais foram observadas nos menores patamares de renda e as piores entre os mais velhos e os "não casados". Para as mulheres, as chances de estarem "não casadas" aumentaram significativamente quanto pior era o seu nível educacional. O "status de coabitação" foi o que mais influenciou o apoio funcional, onde "morar só" aumentou significativamente as chances de não ocorrerem as trocas sociais. Os modelos de regressão logística múltipla construídos separadamente por gênero sugerem que idade, estado civil, renda per capita e escolaridade estão associados com as redes sociais entre os idosos. No entanto, essas relações manifestam-se de modos desiguais entre gêneros e entre as características sócio-demográficas para as diferentes dimensões da rede social.This study aimed to describe the distribution of social support networks for the elderly in the City of São Paulo, Brazil, based on socioeconomic and demographic characteristics. A probability sample of 1,568 elderly persons (> 60 years was studied (SABE query, focusing on structural and functional dimensions of social networks. Univariate and multiple logistic regression models were used to analyze the data. The best conditions in social networks were in the lowest income levels and the worst among older and unmarried people. For women, unmarried marital status was significantly associated with lower schooling. Cohabiting had the strongest influence on

  20. The structuralist tradition in economics: methodological and macroeconomics aspects

    Directory of Open Access Journals (Sweden)

    FABRÍCIO MISSIO

    2015-06-01

    Full Text Available This paper examines the structuralist tradition in economics, emphasizing the role that structures play in the economic growth of developing countries. Since the subject at hand is evidently too large to cover in a single article, an emphasis has been brought to bear upon the macroeconomic elements of such a tradition, while also exploring its methodological aspects. It begins by analysing some general aspects of structuralism in economics (its evolution and origins associated with ECLAC thought, in this instance focusing on the dynamics of the center-periphery relationship. Thereafter, the macroeconomic structuralism derived from the works of Taylor (1983, 1991 is presented, followed by a presentation of neo-structuralism. Centred on the concept of systemic competitiveness, this approach defines a strategy to achieve the high road of globalization, understood here as an inevitable process in spite of its engagement being dependent on the policies adopted. The conclusions show the genuine contributions of this tradition to economic theory.

  1. Aspects of Organic Marine Pollution

    International Nuclear Information System (INIS)

    Duursma, E.K.; Marchand, M.

    1976-01-01

    A literature review is intended to summarize available information on the various aspects of pollution of the marine environment by organic substances. Chemicals such as pesticides, particularly the organo chlorine insecticides and herbicides, polychlorinated biphenyls (PCBs), oil and hydrocarbons, sewage, detergents, wastes from wood processing industries, cyanides and other organic pollutants are discussed. For each of these pollutants, information has been presented on their determination, their distribution in the marine environment, biogeochemical phenomena such as persistence, degradation and bioaccumulation, and finally on their effects on marine organisms. (author)

  2. Mechanical engineering aspects of TFTR

    International Nuclear Information System (INIS)

    Citrolo, J.C.

    1983-04-01

    This paper briefly presents the principles which characterize a tokamak and discusses the mechanical aspects of TFTR, particularly the toroidal field coils and the vacuum chamber, in the context of being key components common to all tokamaks. The mechanical loads on these items as well as other design requirements are considered and the solutions to these requirements as executed in TFTR are presented. Future technological developments beyond the scope of TFTR, which are necessary to bring the tokamak concept to a full fusion-power system, are also presented. Additional methods of plasma heating, current drive, and first wall designs are examples of items in this category

  3. Procedural Aspects Regarding International Arbitration

    Directory of Open Access Journals (Sweden)

    Berlingher Remus Daniel

    2015-07-01

    Full Text Available Socio-economic changes have led to significant changes with regard to the institutions regulated by the 1865 Code of Civil Procedure and other laws, such as Law no. 105/1992 on the regulation of private international law. Among the institutions that have undergone these reconfigurations in the regulation of the Code of Civil Procedure, which entered into force in 2013, one that stands out is arbitration. Our study will analyze the main aspects of private international law arbitration: arbitration agreement, the arbitral tribunal, the proceedings in the matter, as well as the recognition and enforcement of foreign arbitral awards

  4. Regulatory aspects of food irradiation

    International Nuclear Information System (INIS)

    Nowlan, N.V.

    1985-01-01

    The role of the Nuclear Energy Board in relation to radiation safety in Ireland is described. The Board has the duty to control by licence all activities involving ionizing radiation, as well as providing advice and information to the Government on all aspects of radiation safety. The licensing procedures used by the Board, including site approval, construction, commissioning, source loading and commercial operation, in the licensing of large irradiation facilities were described, and an outline of the proposed new legislation which may become necessary if and when the irradiation of food for commercial purposes begins in Ireland is given

  5. Modern Aspects of Electrochemistry 40

    CERN Document Server

    White, Ralph E

    2007-01-01

    This volume in the acclaimed series Modern Aspects of Electrochemistry starts with a dedication to the late Professor Brian Conway who for 50 years helped to guide this series to its current prominence. The remainder of the volume is then devoted to the following topics: PEM fuel cells; the use of graphs in electrochemical reaction newtworks; nanomaterials in Lithium-ion batteries; direct methanolf fuel cells (two chapters); fuel cell catalyst layers. The book is for electrochemists, electrochemical engineers, fuel cell workers and energy generation workers.

  6. Nutritional aspects related to endometriosis

    Directory of Open Access Journals (Sweden)

    Gabriela Halpern

    2015-12-01

    Full Text Available SUMMARY This literature review analyzed the evidence on nutritional aspects related to the pathogenesis and progression of endometriosis. Diets deficient in nutrients result in changes in lipid metabolism, oxidative stress and promote epigenetic abnormalities, that may be involved in the genesis and progression of the disease. Foods rich in omega 3 with anti-inflammatory effects, supplementation with Nacetylcysteine, vitamin D and resveratrol, in addition to the increased consumption of fruits, vegetables (preferably organic and whole grains exert a protective effect, reducing the risk of development and possible regression of disease. Dietary re-education seems to be a promising tool in the prevention and treatment of endometriosis.

  7. Aspect-oriented programming evaluated

    CERN Document Server

    Kleinschmager, Sebastian

    2012-01-01

    Hauptbeschreibung Aspect-oriented-programming is a relatively new technique that has evolved on top of the already well-established approach of object-oriented programming. When it is used correctly, it promises to remove many redundant parts of a code that appear repeatedly in an application, essentially untangling the original code. Thus, it can lead to a cleaner, more separated software design, to greater modularity and maintainability. Time-savings in software engineering can also be huge cost-savings, and anything that increases software quality is a welcome sight in an industr

  8. Modeling business processes: theoretical and practical aspects

    Directory of Open Access Journals (Sweden)

    V.V. Dubininа

    2015-06-01

    Full Text Available The essence of process-oriented enterprise management has been examined in the article. The content and types of information technology have been analyzed in the article, due to the complexity and differentiation of existing methods, as well as the specificity of language, terminology of the enterprise business processes modeling. The theoretical aspects of business processes modeling have been reviewed and the modern traditional modeling techniques received practical application in the visualization model of retailers activity have been studied in the article. In the process of theoretical analysis of the modeling methods found that UFO-toolkit method that has been developed by Ukrainian scientists due to it systemology integrated opportunities, is the most suitable for structural and object analysis of retailers business processes. It was designed visualized simulation model of the business process "sales" as is" of retailers using a combination UFO-elements with the aim of the further practical formalization and optimization of a given business process.

  9. Fundamental and applied aspects of astronomical seeing

    International Nuclear Information System (INIS)

    Coulman, C.E.

    1985-01-01

    It is pointed out that despite recent advances in the use of spacecraft as observatory platforms, much astronomy is still conducted from the surface of the earth. The literature on astronomical seeing and observatory site selection is widely scattered throughout journals and conference reports concerned with various disciplines. This survey has the objective to represent the state of the subject up to 1982. A description of the history and prospects of the considered subject is presented, and the optics of seeing are examined. The meteorology of seeing is discussed, taking into account aspects of micrometeorology and small-scale turbulence near the surface, the diurnal cycle in the planetary boundary layer, the temperature structure above the planetary boundary layer, and the effects of terrain. Attention is given to the calculation of system performance from microthermal data, optical methods for the measurement of seeing, and techniques for minimizing image-degrading effects of the atmosphere. 279 references

  10. [Physiological aspects of music and longevity].

    Science.gov (United States)

    Dymnikowa, M

    The article provides an overview of the results of studies on the effect of music on the function of various physiological systems of the organism including the nervous, cardiovascular and endocrine systems, also on the effect of Mozart's music and the later mature Baroque music. Particular attention is paid to information on the influence of different kinds of music (classical, jazz and rock), of the nature and of the degree of musical activity (listeners, amateurs and professional performers) on cognitive and behavioral function, on health status, life expectancy and longevity. Structural acoustical attributes of music defining its treatment effect, are described with the comparison of aspects of rock music and of classical music. The article also considers the prospects for using of music in the treatment and prevention of age-associated diseases.

  11. Some Micromechanical Aspects of Damage and Fracture

    Directory of Open Access Journals (Sweden)

    P. Brož

    2000-01-01

    Full Text Available The failure mode is described by means of elasto-plastic fracture mechanics and the main aspects of fatigue crack behaviour are itemized. The crux of the matter is the presentation of the pplicability limits of the three substantially different fatigue fracture mechanics equations based on fatigue crack propagation development. In the course of this, the microstructural effects,  predominantly crystallographic identification, grain dimension, and second phase structures are considered. For some sorts of FCC polycrystalline metals, the fatigue life and micro-damage heterogeneity are investigated, especially the stage of early plastic fatigue damage initiation while emphasizing slip theory and the localization homogenization technique. An internal damage variable ds is applied to illustrate of the micro-damage of each slip system.

  12. Statistical aspects of fish stock assessment

    DEFF Research Database (Denmark)

    Berg, Casper Willestofte

    statistical aspects of fish stocks assessment, which includes topics such as time series analysis, generalized additive models (GAMs), and non-linear state-space/mixed models capable of handling missing data and a high number of latent states and parameters. The aim is to improve the existing methods...... for stock assessment by application of state-of-the-art statistical methodology. The main contributions are presented in the form of six research papers. The major part of the thesis deals with age-structured assessment models, which is the most common approach. Conversion from length to age distributions...... in the catches is a necessary step in age-based stock assessment models. For this purpose, GAMs and continuation ratio logits are combined to model the probability of age as a smooth function of length and spatial coordinates, which constitutes an improvement over traditional methods based on area...

  13. Mathematical aspects of multi-porosity continua

    CERN Document Server

    Straughan, Brian

    2017-01-01

    This book is devoted to describing theories for porous media where such pores have an inbuilt macro structure and a micro structure. For example, a double porosity material has pores on a macro scale, but additionally there are cracks or fissures in the solid skeleton. The actual body is allowed to deform and thus the underlying theory is one of elasticity. Various different descriptions are reviewed. Chapter 1 introduces the classical linear theory of elastodynamics together with uniqueness and continuous dependence results. Chapters 2 and 3 review developments of theories for double and triple porosity using a pressure-displacement structure and also using voids-displacement. Chapter 4 compares various aspects of the pressure-displacement and voids-displacement theories via uniqueness studies and wave motion analysis. Mathematical analyses of double and triple porosity materials are included concentrating on uniqueness and stability studies in chapters 5 to 7. In chapters 8 and 9 the emphasis is on wa...

  14. Challenges of Recognition of the Psychiatric Aspects of Intimate ...

    African Journals Online (AJOL)

    hanumantp

    . Achor JU, Ibekwe PC1 .... Barriers to Recognition and Treatment of. Psychiatric Aspects of Partner Violence. A number of ..... Ann Intern Med 1978;88:251-8. 50. Angel R, Thoits P. The impact of culture on the cognitive structure of illness.

  15. METHODOLOGICAL ASPECTS OF THE INTERNAL CONTROL SYSTEM FORMATION

    Directory of Open Access Journals (Sweden)

    Larisa I. Egorova

    2014-01-01

    Full Text Available The methodological aspects of the internal control system formation are stated in the article. The great attention is focused on the problems of financial statements misrepresentation. The basic principles and structure of the internal control system are discussed in this article.

  16. The perfective and imperfective aspects in Xhosa | Savić ...

    African Journals Online (AJOL)

    The underlying assumption is that, unlike durative and iterated ones, bounded events cannot hold true at more than one point in time. The results ... The choice of aspect in these cases points toward other factors, such as factuality, number of occurrences, information structure, and sequencing of eventualities. Keywords: ...

  17. Aspect-based Relevance Learning for Image Retrieval

    NARCIS (Netherlands)

    M.J. Huiskes (Mark)

    2005-01-01

    htmlabstractWe analyze the special structure of the relevance feedback learning problem, focusing particularly on the effects of image selection by partial relevance on the clustering behavior of feedback examples. We propose a scheme, aspect-based relevance learning, which guarantees that feedback

  18. Investigating legal aspects of cyberbullying.

    Science.gov (United States)

    Paul, Simone; Smith, Peter K; Blumberg, Herbert H

    2012-11-01

    In the UK schools are required by law to protect students from bullying; the responsibility of teachers to govern such behaviour has been extended outside the school setting to include cyberbullying. In this investigation, cyberbullying in secondary education is explored from the student perspective using a qualitative method of enquiry. Reported awareness and understanding about the legal aspects of cyberbullying are investigated; consideration is given to legislation, cybercrime, children's rights, school sanctions and safeguarding responsibilities. A total of 197 male and female students aged between 11 and 14 years old participated. Despite the availability of information on guidelines and legislation at national, local, and school level, this does not appear to have reached ground level of the individual student. There is a considerable gap between what students should know and what they report to be aware of with regard to legal aspects of cyberbullying. To address concerns of keeping up with the pace of change in cyberbullying, a collaborative approach is required with young people and adults sharing expertise.

  19. Endoscopic Aspects of Gastric Syphilis

    Directory of Open Access Journals (Sweden)

    Mariana Souza Varella Frazão

    2012-01-01

    Full Text Available Introduction. Considered as a rare event, gastric syphilis (GS is reported as an organic form of involvement. Low incidence of GS emphasizes the importance of histopathological analysis. Objective. We aim to characterize GS endoscopic aspects in an immunocompetent patient. Case Report. A 23-year-old man presented with epigastric pain associated with nausea, anorexia, generalized malaise and 11 kg weight loss that started 1 month prior to his clinical consultation. Physical examination was normal except for mild abdominal tenderness in epigastrium. Endoscopy observed diminished gastric expandability and diffuse mucosal lesions, from cardia to pylorus. Gastric mucosa was thickened, friable, with nodular aspect, and associated with ulcers lesions. Gastric biopsies were performed, and histopathological analysis resulted in dense inflammatory infiltration rich in plasmocytes. Syphilis serologies were positive for VDRL and Treponema pallidum reagents. Immunohistochemical tests were positive for Treponema pallidum and CD138. The patient was treated with penicillin, leading to resolution of his clinical complaints and endoscopic findings. Conclusion. Diagnosis suspicion of GS is important in view of its nonspecific presentation. Patients with gastric symptoms that mimic neoplastic disease should be investigated thoroughly based on the fact that clinical, endoscopic, and histological findings can easily be mistaken for lymphoma or plastic linitis.

  20. PRACTICAL ASPECTS REGARDING FIDUCIARY OPERATIONS

    Directory of Open Access Journals (Sweden)

    Bazil Oglindă

    2016-11-01

    Full Text Available The trusts have been frequently used in the countries which function under the Anglo-Saxon law system, but it most certainly represents an innovation in the new Romanian legislation. For this reason, in this paper, we tried to highlight the main differences between the trust regulated in the Romanian Civil code and its corespondent in other legal systems. Observing that the trust in an institution that is mainly theoretical, and the reluctance of practicioners in using it, we tried to analyze the trust, regarding its practical side. In this paper, we will take into consideration the following aspects: the rights that the trustee acquires after establishing the trust, that will be explained through the new regulations regarding the division of assets, the quality of the parties and the limits in which the trustee may be held liable. Other important aspects are: the means that the new regulations provide in order to protect the interests of the creditors and at the same time, the fiduciary assets; the formalities which the law requires and the means of termination of the contract. In the end, in order to identify alternative solutions, we will compare the trust (regulated in the Civil code with the management of assets that belong to a third party.

  1. Charge ordering in low dimensional organic conductors: Structural aspects

    Energy Technology Data Exchange (ETDEWEB)

    Pouget, Jean-Paul; Foury-Leylekian, Pascale [Laboratoire de Physique des Solides, Universite Paris-sud, CNRS UMR 8502, Batiment 510, 91405 Orsay Cedex (France); Alemany, Pere [Departament de Quimica Fisica and Institut de Quimica Teorica i Computacional (IQTCUB), Universitat de Barcelona, Diagonal 627, 08028 Barcelona (Spain); Canadell, Enric [Institut de Ciencia de Materials de Barcelona, CSIC, Campus UAB, 08193 Bellaterra (Spain)

    2012-05-15

    The paper points out the importance of the coupling between anions and donors in order to achieve the 4k{sub F} charge localization observed in (TMTTF){sub 2}PF{sub 6}, {delta}-(EDT-TTF-CONMe{sub 2}){sub 2}Br and (o-DMTTF){sub 2}Cl/Br salts, the 2k{sub F} charge density wave (CDW) ground state of {alpha}-(BEDT-TTF){sub 2}KHg(SCN){sub 4} and the metal to insulator transition of {alpha}-(BEDT-TTF){sub 2}I{sub 3}. This coupling leads to a cooperative displacement wave of the anions accompanied by a modulation of the density of {pi} holes on the donors. We distinguish two principal anion-donor coupling mechanisms: a direct mechanism via the Hartree anion potential on donor sites and an indirect mechanism via the polarization of {sigma} bonds activated by the modification of the H bonds network. Both kinds of interaction are tuned by the relative displacement of the anions with respect to the donors. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  2. Structural aspects of the atmospheric aerosol of the Amazon basin

    International Nuclear Information System (INIS)

    Artaxo Netto, P.E.; Orsini, C.M.Q.

    1982-01-01

    The results presented on this paper may be considered as complementary to the ones published on two previous papers about the natural atmospheric aerosol of the Amazon Basin, and the effects, on these physical-chemical systems of the large scale brushfires carried out from time to time on that region. The experiments have been performed in August-September, 1980, simultaneously to the ones of the 'Projeto Queimadas - 1980' promoted by the National Center for Atmospheric Research from the U.S.A.. The new results here in presented are size distribution concentration data as log-probability curves for the detected tracer-elements; from these curves, by introducing a new technique, is was possible to derive the corresponding log-normal curves. These last curves can be used conveniently to characterize the atmospheric aerosol system which is under investigation. (Author) [pt

  3. Structural Aspects of Bacterial Outer Membrane Protein Assembly.

    Science.gov (United States)

    Calmettes, Charles; Judd, Andrew; Moraes, Trevor F

    2015-01-01

    The outer membrane of Gram-negative bacteria is predominantly populated by β-Barrel proteins and lipid anchored proteins that serve a variety of biological functions. The proper folding and assembly of these proteins is essential for bacterial viability and often plays a critical role in virulence and pathogenesis. The β-barrel assembly machinery (Bam) complex is responsible for the proper assembly of β-barrels into the outer membrane of Gram-negative bacteria, whereas the localization of lipoproteins (Lol) system is required for proper targeting of lipoproteins to the outer membrane.

  4. Structural and chemical aspects of HPMA copolymers as drug carriers

    Czech Academy of Sciences Publication Activity Database

    Ulbrich, Karel; Šubr, Vladimír

    2010-01-01

    Roč. 62, č. 17 (2010), s. 150-166 ISSN 0169-409X R&D Projects: GA AV ČR KAN200200651; GA AV ČR IAAX00500803 Institutional research plan: CEZ:AV0Z40500505 Keywords : drug-delivery systems * N-(2-hydroxypropyl)methacrylamide * polymer drug conjugates Subject RIV: CD - Macromolecular Chemistry Impact factor: 13.577, year: 2010

  5. Some aspects of the morphology, population structure and larval ...

    African Journals Online (AJOL)

    1987-06-26

    Jun 26, 1987 ... individually in 0,5% amphibian saline for 48 h. The solution, which prevented hatching, was changed every 6 h and the egg counts were related to the worm loads determined after dissection. In order to observe the vertical movement of newly hatched coracidia, approximately 2000 were released into ale ...

  6. Molecular structure investigation and tautomerism aspects of (E)-3 ...

    Indian Academy of Sciences (India)

    Saudi M N S, El Semary M M A and El Sawaf G 2002. Pharmazie 57 519. 17. Amal Raj A, Raghunathan R, Sridevikumari M R and. Raman N 2003 Bioorg. Med. Chem. 11 407. 18. Heydri R and Tahamipour B 2011 Chin. Chem. Lett. 22. 1281. 19. Nanubolu J B, Sridhar B and Ravikumar K 2014. CrystEngComm 16 10602.

  7. Structural aspects of antioxidant action of selected natural polyphenol

    Czech Academy of Sciences Publication Activity Database

    Racková, L.; Drábiková, K.; Jančinová, V.; Perečko, T.; Šmidrkal, J.; Harmatha, Juraj; Toth, J.; Košťálová, D.; Bezek, S.; Štefek, M.; Nosál, R.

    2009-01-01

    Roč. 43, Suppl.1 (2009), s. 39-39 ISSN 1071-5762. [Annual Meeting of the Society for Free Radical Research. 26.08.2009-29.08.2009, Rome] Institutional research plan: CEZ:AV0Z40550506 Keywords : resveratrol * pterostilbene Subject RIV: CC - Organic Chemistry

  8. Structural Design Aspects and Criteria for Military UAV

    National Research Council Canada - National Science Library

    Neubauer, Martin; Guenther, Georg; Fuellhas, Konrad

    2007-01-01

    .... These criteria used have been evolved and advanced for large fleets of manned platforms using the experience from ground and flight tests and thousands of mission flight hours for different usage...

  9. Photogeology: Part G: structural aspects of Imbrium sculpture

    Science.gov (United States)

    Scott, David H.

    1972-01-01

    Apollo 16 metric photographs taken at low to high Sun angles (from approximately 7° to 40°) provide the first stereographic coverage of the distinctive landforms collectively referred to as "Imbrium sculpture" (refs. 29-40 and 29-41). The sculpture consists of a series of nearly linear ridges and troughs extending radially outward for more than 1000 km from the rim of the Imbrium Basin. The sculpture is particularly well developed in the highlands southwest of the basin, where individual segments have lengths measured in tens of kilometers. THe origin of the ridges and troughs, whether by deposition and impact scoring by fluidized clouds of ejecta from the Imbrium Basin or by faulting and volcanism during and subsequent to basin formation, is controversial. Similar appearing features occur around other large basins on both the near and far sides of the Moon; thus, information leading to a better interpretation of Imbrium sculpture has significance throughout the Moon.

  10. Structural aspects of quantum field theory and noncommutative geometry

    CERN Document Server

    Grensing, Gerhard

    2013-01-01

    This book is devoted to the subject of quantum field theory. It is divided into two volumes. The first can serve as a textbook on the main techniques and results of quantum field theory, while the second treats more recent developments, in particular the subject of quantum groups and noncommutative geometry, and their interrelation. The first volume is directed at graduate students who want to learn the basic facts about quantum field theory. It begins with a gentle introduction to classical field theory, including the standard model of particle physics, general relativity, and also supergravity. The transition to quantized fields is performed with path integral techniques, by means of which the one-loop renormalization of a self-interacting scalar quantum field, of quantum electrodynamics, and the asymptotic freedom of quantum chromodynamics is treated. In the last part of the first volume, the application of path integral methods to systems of quantum statistical mechanics is covered. The book ends with a r...

  11. Aspects of population structure of Parechinus angulosus Leske ...

    African Journals Online (AJOL)

    A weighted tunny line marked at 1 m intervals was used for this purpose. Every. 10 m sector was sampled randomly by means of a 0,25 m2 quadrat with one movable side to facilitate operation among kelp stipes. The quadrat method of sampling used here can be regarded as a reliable method for urchin densities as were.

  12. Structural aspects of vaults constructed with infill elements

    NARCIS (Netherlands)

    Kamerling, M.W.

    2011-01-01

    This paper describes for the Fusée Ceramique vaults the effect of the time dependent deformations concerning the load transfer. Especially the creep and shrinkage of concrete will change the distribution of the loads acting on a Fusée Ceramique vault considerately. Recommendations for infill

  13. Structural aspects of protein kinase ASK1 regulation

    Czech Academy of Sciences Publication Activity Database

    Obšil, Tomáš; Obšilová, Veronika

    2017-01-01

    Roč. 66, 1 Dec (2017), s. 31-36 ISSN 2212-4926 R&D Projects: GA ČR(CZ) GA16-02739S; GA MŠk(CZ) ED1.1.00/02.0109 Institutional support: RVO:67985823 Keywords : ASK1 kinase * apoptosis * thioredoxin * 14-3-3 protein Subject RIV: CE - Biochemistry OBOR OECD: Biochemistry and molecular biology

  14. Some aspects of the morphology, population structure and larval ...

    African Journals Online (AJOL)

    The parasite has a high prevalence of infection (68,9%) in the X. laevis population studied and shows a preference for attachment in the anterior duodenum. Approximately 76% of the worms recovered were juveniles. Coracidia had an LT50 of 6 h and transmission is thought to take place in darkness at the sediment/water ...

  15. Chemistry of the Calceolaria Genus. Structural and Biological Aspects

    Directory of Open Access Journals (Sweden)

    Juan A. Garbarino

    2000-03-01

    Full Text Available Autochthonous species of the Calceolaria (Scrophulariaceae genus are studied. From their apolar extracts 55 new diterpenes of six skeleton types, naphtoquinones and flavonoids have been isolated. Among the different diterpenes malonic substitutions and bis-diterpenes in which both units are joined by a malonic acid unit stand out. Pimaranes present C-9 epimerisation and, consequently, H-9 has the same orientation as Me-20. From C.sessilis naphthoquinones with antichagasic activity have been isolated; and the biotransformation of 2α,19-dihydroxy-9-epi-entpimara-7,15-diene with Giberella fujikuroi produced 7 new diterpenes.

  16. Molecular structure investigation and tautomerism aspects of (E)-3 ...

    Indian Academy of Sciences (India)

    calculations. The effect of the intermolecular N-H—. O H-bonding interactions on the calculated geometric parameters has been tested. The electronic spectra were assigned with the aid of the TD-DFT calculations. 2. Experimental. 2.1 Synthesis and spectral investigations. A mixture of indolin-2-one 1 (1.5 mmol, 200 mg), ...

  17. Structural aspects of English-Afrikaans intrasentential code-switching

    African Journals Online (AJOL)

    The experimental techniques included tasks requiring judgements of the relative acceptability of sentences presented in both visual and auditory modalities, a sentence completion task, and a picture description task. In each task, stimuli were specifically constructed to gather information on one of the 10 constructions.

  18. Polyhedral aspects of score equivalence in Bayesian network structure learning

    Czech Academy of Sciences Publication Activity Database

    Cussens, J.; Haws, D.; Studený, Milan

    2017-01-01

    Roč. 164, 1-2 (2017), s. 285-324 ISSN 0025-5610 R&D Projects: GA ČR GA13-20012S; GA ČR(CZ) GA16-12010S Institutional support: RVO:67985556 Keywords : family- variable polytope * characteristic-imset polytope * score equivalent face/facet * supermodular set function Subject RIV: BA - General Mathematics OBOR OECD: Applied mathematics Impact factor: 2.446, year: 2016 http://library.utia.cas.cz/separaty/2017/MTR/studeny-0475315.pdf

  19. The Large Scale Structure: Polarization Aspects R. F. Pizzo

    Indian Academy of Sciences (India)

    polarized filaments at the borders of the central radio halo. ... Halo models can be grouped in two main classes: (i) primary models, where electrons undergo in-situ acceleration by turbulent gas motion or by shocks (e.g. Brunetti et al. ..... location of the filaments, therefore, should be considered as due to a projection effect.

  20. Immune Aspects of Female Infertility

    Directory of Open Access Journals (Sweden)

    Andrea Brazdova

    2016-05-01

    Full Text Available Immune infertility, in terms of reproductive failure, has become a serious health issue involving approximately 1 out of 5 couples at reproductive age. Semen that is defined as a complex fluid containing sperm, cellular vesicles and other cells and components, could sensitize the female genital tract. The immune rejection of male semen in the female reproductive tract is explained as the failure of natural tolerance leading to local and/or systemic immune response. Present active immune mechanism may induce high levels of anti-seminal/sperm antibodies. It has already been proven that iso-immunization is associated with infertility. Comprehensive studies with regards to the identification of antibody-targets and the determination of specific antibody class contribute to the development of effective immuno-therapy and, on the other hand, potential immuno-contraception, and then of course to complex patient diagnosis. This review summarizes the aspects of female immune infertility.

  1. Biomechanical aspects of playing surfaces.

    Science.gov (United States)

    Nigg, B M; Yeadon, M R

    1987-01-01

    The purpose of this paper is to discuss some biomechanical aspects of playing surfaces with special focus on (a) surface induced injuries, (b) methodologies used to assess surfaces and (c) findings from various sports. The paper concentrates primarily on questions related to load on the athlete's body. Data from epidemiological studies suggest strongly that the surface is an important factor in the aetiology of injuries. Injury frequencies are reported to be significantly different for different surfaces in several sports. The methodologies used to assess surfaces with respect to load or performance include material tests and tests using experimental subjects. There is only little correlation between the results of these two approaches. Material tests used in many standardized test procedures are not validated which suggests that one should exercise restraint in the interpretation of these results. Point elastic surfaces are widely studied while area elastic surfaces have received little attention to date. Questions of energy losses on sport surfaces have rarely been studied scientifically.

  2. Environmental, legal and managerial aspects

    International Nuclear Information System (INIS)

    1978-09-01

    This U.S. contribution to the syllabus for Subgroup 5C treats with environmental and ecological aspects specific to fast breeder reactors, physical protection and safeguarding of the FBR cycle, fuel cycle centers (site selection problems for different degrees of collocation) and administrative and legal problems. Decommissioning of an FBR power plant, syllabus item C.1.7, is treated in separate contribution, more information on advanced safeguards for the fast breeder fyel cycle is contained in the contribution, USA WG 5C-tbd. A key conclusion of this is that with safeguards planning initiated early in the development of the FBR fuel cycle, time is available to develop, evaluate, and implement improved safeguards techniques and incorporate them into the design phase of all FBR cycle facilities

  3. Aspect in Greek Future Forms

    DEFF Research Database (Denmark)

    Lucas, Sandra

    2014-01-01

    Medieval Greek had three future periphrases making use of a finite verb and an infinitive: μέλλω + INF, ἔχω + INF, θέλω + INF. Given the parallel nature of the periphrases as well as the fact that the infinitive existed in both a perfective and an imperfective version, it might be expected...... of the Modern Greek verbal system: μέλλω + INF has a much higher ratio of imperfective infinitives than the two other periphrases especially in AD I, ἔχω + INF starts out using only the perfective infinitive when referring to the future, and θέλω + INF distinguishes for aspect before it gains future meaning...

  4. Legal aspects of nuclear energy

    International Nuclear Information System (INIS)

    Kraut, A.

    1981-01-01

    The legal basis for the use of nuclear energy is generally given by an Atomic Energy Act. Additionally, however, a system of regulations and standards has to be set up to lay down more detailed requirements. The fundamental philosophy and strategy has to be specified by governmental organizations. For the specification and implementation of the requirements some minimum organizational arrangements are necessary, which are not only restricted to governmental organizations. Furthermore procedural regulations have to be laid down before the implementation phase. This includes aspects like public participation in the licensing procedure. In practice, however, the implementation of the legal requirements always shows some weakness of the basic legal requirements. To learn from this experience some examples are presented, which gave rise to difficulties in the implementation procedure. (orig./RW)

  5. THEORETICAL ASPECTS OF FILMMUSIC STUDY

    Directory of Open Access Journals (Sweden)

    Egorova Tatiana K.

    2014-04-01

    Full Text Available In this article, author analyzes the theoretical aspects of the film music study taking into account with modern realities in the development of world film-process and attempts to its scientific understanding. Need for innovation in this area is long overdue, because the existing on this topic nonfiction no longer meets the new aesthetic and art-practical achievements and innovations in the film music development at the XXI century. Related to the phenomenon of music in screen arts a number of new terms and concepts require a certain adjustment as well. Their range of action is not yet fully defined. Author of the article offered her version of their content-semantic interpretation (largely experimental designed to promote new research methods for the film music study.

  6. Geological aspects of acid deposition

    International Nuclear Information System (INIS)

    Bricker, O.P.

    1984-01-01

    The general pattern of rain falling on the earth and reacting with the materials of the lithosphere (the weathering reactions so familiar to every beginning geology student) began soon after the earth was formed and has continued to the present. Anthropogenic additions to the natural acidic components of the atmosphere have increased since the time of the industrial revolution until they now rival or exceed those of the natural system. The severity of the environmental perturbations caused by these anthropogenic additions to the atmosphere has become a hotly debated topic in scientific forums and in the political arena. The six chapters in this book address various aspects of the acid deposition phenomenon from a geological perspective. It is hoped that the geological approach will be useful in bringing the problem more clearly into focus and may shed light on the geochemical processes that modify the chemical composition of acid deposition after it encounters and reacts with the materials of the lithosphere

  7. Psychological aspects of cancer patients

    Directory of Open Access Journals (Sweden)

    Graça Cardoso

    2014-06-01

    Full Text Available Cancer is accompanied by important psychological distress experienced by both patient and family. From the moment of the diagnosis on, the patient has to develop a great number of mechanisms and tasks of adjustment to the illness and its circumstances. The high prevalence of anxiety and depressive disorders during the course of cancer increases in the end stage disea‐ se. Therefore, a global plan of intervention integrating somatic and psychological/ psychiatric care throughout all the phases of the illness is crucial in the treatment of these patients. Health professionals working on this field can also experience emotional reactions to their patients’ suffering. They should be aware of the emotional aspects involved and develop training to help them intervene adequately with the patient and the family. The articulation between oncologists, palliative care professionals, and mental health care teams can be of great help in providing good quality of care to cancer patients.

  8. Molecular aspects of Down syndrome.

    Science.gov (United States)

    Dutta, Samikshan; Nandagopal, Krishnadas; Gangopadhyay, Prasanta Kumar; Mukhopadhyay, Kanchan

    2005-04-01

    Molecular aspects of Down syndrome (DS), a major genetic cause for mental retardation, commonly associated with trisomy 21 are discussed. Two different hypotheses have been speculated to better understand the disease. One believes that increased gene dosage contributes to the phenotypic abnormalities; the other correlates genetic imbalance with DS pathogenesis. To sustain these hypotheses, different murine models have been developed. Experimental models as well as sequencing of human chromosome 21 helped in speculating a few possible candidate genes for DS. However, the phenotypic changes involved with this neurological disorder vis-a-vis the enhanced number of genes, still remain unexplained. Improvement in screening pattern, model system, as well as better understanding of the disease etiology may help in developing efficacious therapeutic regimes for DS.

  9. Technical aspects of fuel reprocessing

    International Nuclear Information System (INIS)

    Groenier, W.S.

    1982-02-01

    The purpose of this paper is to present a brief description of fuel reprocessing and some present developments which show the reliability of nuclear energy as a long-term supply. The following topics are discussed: technical reasons for reprocessing; economic reasons for reprocessing; past experience; justification for advanced reprocessing R and D; technical aspects of current reprocessing development. The present developments are mainly directed at the reprocessing of breeder reactor fuels but there are also many applications to light-water reactor fuel reprocessing. These new developments involve totally remote operation, and maintenance. To demonstrate this advanced reprocessing concept, pilot-scale demonstration facilities are planned with commercial application occurring sometime after the year 2000

  10. Medical aspects of nuclear armament

    International Nuclear Information System (INIS)

    Janse, M.J.; Schene, A.; Koch, K.

    1983-01-01

    The authors highlight a few medical, biological and psycological aspects of the use of nuclear weapons, drawing attention to their viewpoint that doctors should actively participate in the fight against nuclear armament. The short and long-term radiation effects on man and ecology are presented based on the Hiroshima and Nagasaki experiences. The danger of human error within this framework is emphasised and it is suggested that it is the medical profession's duty to point out how the effect of stress and boredom can lead to a nuclear catastrophe. Medical expertise may also help in the identification of unstable personalities among those who have access to nuclear weapons and in the understanding of the psycology of international conflicts and the psychopathology of those leaders who would use nuclear war as an instrument of national policy. Finally the effects of the nuclear war threat on children and teenagers are considered. (C.F.)

  11. Scintillation counter, maximum gamma aspect

    International Nuclear Information System (INIS)

    Thumim, A.D.

    1975-01-01

    A scintillation counter, particularly for counting gamma ray photons, includes a massive lead radiation shield surrounding a sample-receiving zone. The shield is disassembleable into a plurality of segments to allow facile installation and removal of a photomultiplier tube assembly, the segments being so constructed as to prevent straight-line access of external radiation through the shield into radiation-responsive areas. Provisions are made for accurately aligning the photomultiplier tube with respect to one or more sample-transmitting bores extending through the shield to the sample receiving zone. A sample elevator, used in transporting samples into the zone, is designed to provide a maximum gamma-receiving aspect to maximize the gamma detecting efficiency. (U.S.)

  12. Some Elementary Aspects of Means

    Directory of Open Access Journals (Sweden)

    Mowaffaq Hajja

    2013-01-01

    Full Text Available We raise several elementary questions pertaining to various aspects of means. These questions refer to both known and newly introduced families of means, and include questions of characterizations of certain families, relations among certain families, comparability among the members of certain families, and concordance of certain sequences of means. They also include questions about internality tests for certain mean-looking functions and about certain triangle centers viewed as means of the vertices. The questions are accessible to people with no background in means, and it is also expected that these people can seriously investigate, and contribute to the solutions of, these problems. The solutions are expected to require no more than simple tools from analysis, algebra, functional equations, and geometry.

  13. Comparative Aspects of Canine Melanoma

    Directory of Open Access Journals (Sweden)

    Adriana Tomoko Nishiya

    2016-02-01

    Full Text Available Melanomas are malignant neoplasms originating from melanocytes. They occur in most animal species, but the dog is considered the best animal model for the disease. Melanomas in dogs are most frequently found in the buccal cavity, but the skin, eyes, and digits are other common locations for these neoplasms. The aim of this review is to report etiological, epidemiological, pathological, and molecular aspects of melanomas in dogs. Furthermore, the particular biological behaviors of these tumors in the different body locations are shown. Insights into the therapeutic approaches are described. Surgery, chemotherapy, radiotherapy, immunotherapy, and the outcomes after these treatments are presented. New therapeutic perspectives are also depicted. All efforts are geared toward better characterization and control of malignant melanomas in dogs, for the benefit of these companion animals, and also in an attempt to benefit the treatment of human melanomas.

  14. Holistic aspects of quantum mechanics

    International Nuclear Information System (INIS)

    Pietschmann, H.

    1987-01-01

    Aspects of quantum mechanics irreconcilable with classical physics are outlined. Quantum mechanics started with a negative statement about reality, namely: it is impossible to determine momentum and position of a particle simultaneously. Meanwhile it has generated an impressive body of predictions which can be tested and have been confirmed by suitable experiments. As a consequence a naive, local, materialistic concept of reality must be abolished and a novel approach, the holistic is introduced. This is illustrated by some examples e.g. the Pauli exclusion principle for electrons, the electron capture decay of 135 La as a model of the wavefunction reduction, the Bohr radius of the atom, electron localisation in the atom. An example from the quantum field theory is the calculation of magnetic moments of electron and muon where a particle cannot be considered separately and all other particles must be taken into account. (G.Q.)

  15. Morphometric aspects of Scyllarides latus

    Directory of Open Access Journals (Sweden)

    T. ROMEO

    2004-06-01

    Full Text Available The slipper lobster, Scyllarides latus (Latreille, 1803, is the only representative species of the genusScyllarides in the Mediterranean Sea. In this study, we examined some biological aspects of this species sampled in the Straits of Messina. The specimens were sexed, measured and weighed. The relationships between body measurements (length and width of the carapace, antennal length and length-weight relationship were calculated. Furthermore, the correlation matrix (Pearson’s coefficient was calculated. Two hundred specimens were collected, ranging in size from 81 to 305 mm in total length, and between 21 and 1490 g in weight. A rare juvenile of 39 mm CL was recorded. A sex ratio of 1:1 was found. The carapace length – weight relationship was almost isometric. The wide size range sampled and the presence of a juvenile, indicate an interesting habitat for studying the presence and growth of Scyllarides latus in the Straits of Messina.

  16. Aspects related to 'emission trading'

    International Nuclear Information System (INIS)

    Tutuianu, Ovidiu

    1999-01-01

    The paper presents the aspects of international GHG (greenhouse gases) emission trading, such as: quality of GHG emission data, possible partners, monitoring activity, market mechanisms and difficulties. The following conclusions are drown: - debates on international trade with GHG emissions are currently in a very early stage; - actions are possible and feasible, particularly after Kyoto Conference, as versatile mechanism (besides the Joint Implementation Projects) which have in view the lowering of the global emission costs in different zones of the planet; - difficulties concerning monitoring, reporting and verification, practically preclude implementing a system of emission trading covering all the GHG, all the sources and reservoirs; - an international viable system of emission trading could initiate with a limited number of participants and consideration of only emission categories easy to be confined and surveyed; - existence of a national market and corresponding institutions for monitoring which could booster an international system development

  17. Medical aspects of nuclear armament

    Energy Technology Data Exchange (ETDEWEB)

    Janse, M.J.; Schene, A.; Koch, K.

    1983-06-18

    The authors highlight a few medical, biological and psycological aspects of the use of nuclear weapons, drawing attention to their viewpoint that doctors should actively participate in the fight against nuclear armament. The short and long-term radiation effects on man and ecology are presented based on the Hiroshima and Nagasaki experiences. The danger of human error within this framework is emphasised and it is suggested that it is the medical profession's duty to point out how the effect of stress and boredom can lead to a nuclear catastrophe. Medical expertise may also help in the identification of unstable personalities among those who have access to nuclear weapons and in the understanding of the psycology of international conflicts and the psychopathology of those leaders who would use nuclear war as an instrument of national policy. Finally the effects of the nuclear war threat on children and teenagers are considered.

  18. BEHAVIORAL ASPECTS IN INSURANCE MARKET

    Directory of Open Access Journals (Sweden)

    Stroe Andreea

    2013-07-01

    In this paper there are showed and debated some situation in which psychological effects like loss aversion, reference point, status-quo and framming effects can influence the deccision of the consumer and are not consistent with the standard economic model.In addition to this aspects, Cumulative Prspect Theory enhance the fact that decision makers overestimate low peobabilities and underestimate high probabilities,thus buying inadequate insurance in many situation.in thiss sense, in order to support this idea I tried to make a qualitative presentation of the model used on the insurance market using Prelec function which is the function related with the Cumulative Prospect Theory which can be used in the insurance context.The weak points of the theory of expected utility are explained through this new perspectives and nevertheless aspects like insensivity to bad news concerning incomes,elasticity of price,displacements of status-quo and default,disposition effect and equity premium are taken into consideration.As example,I chose a Kunreuther experiment about insurance decision in with is underlyined the fact that for moderate risk people buy insurance with premiums that exceed the expected loss.There are demands for low deductibles in the the markets for extended guarantees and insurances for mobile phones where was observed that the insurance underwriting rate increases with the probability of loss keeping the expected loss constant.It is better to mention that the theory and the model that are presented here comes as complementary to the economic standard theory not as a substitute.

  19. Geometric, control and numeric aspects of nonholonomic systems

    CERN Document Server

    Cortés Monforte, Jorge

    2002-01-01

    Nonholonomic systems are a widespread topic in several scientific and commercial domains, including robotics, locomotion and space exploration. This work sheds new light on this interdisciplinary character through the investigation of a variety of aspects coming from several disciplines. The main aim is to illustrate the idea that a better understanding of the geometric structures of mechanical systems unveils new and unknown aspects to them, and helps both analysis and design to solve standing problems and identify new challenges. In this way, separate areas of research such as Classical Mechanics, Differential Geometry, Numerical Analysis or Control Theory are brought together in this study of nonholonomic systems.

  20. Some aspects of readaptation of atomic survivors in Hiroshima

    International Nuclear Information System (INIS)

    Vasconcelos, L.A.

    1992-01-01

    An overview of some aspects of psycho social readaptation of the atomic bomb survivors in Hiroshima is presented. Reports from 31 survivors, 8 men and 23 women, were used as data for the analysis. The reports were collected individually through a structured interview, in one of the two hospitals in Hiroshima which deliver services to the survivors. The data were grouped according to the following areas: family, work, health and psychological readaptation. These data were analysed considering the psycho social aspects of disasters and the characteristics of the japanese culture. (M.A.C.)