WorldWideScience

Sample records for cadarache cea

  1. Report transparency and nuclear safety 2007 CEA Cadarache; Rapport transparence et securite nucleaire 2007 CEA Cadarache

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Cadarache for the year 2007. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the report discusses the beginning of the RJH reactor construction, the fourth generation reactors research programs, the implementing of la Rotonde the new radioactive wastes management installation, the renovation of the LECA. (A.L.B.)

  2. KROTOS FCI experimental programme at CEA Cadarache: new features and status

    Energy Technology Data Exchange (ETDEWEB)

    Bonnet, J.M.; Bullado, Y.; Journeau, C.; Fouquart, P.; Piluso, P.; Sergeant, C.; Magallon, D. [CEA-Cadarache, DTN/STRI/LMA, Bat 708, BP1, 13108 Saint Paul lez Durance cedex (France)

    2005-07-01

    Full text of publication follows: KROTOS facility has been operated by the European Commission at JRC-Ispra for many years until 1999 as part of the FARO/KROTOS programme. The programme had to be stopped at JRC due to new EC priorities, and an agreement was concluded with CEA to transfer the KROTOS facility and know-how to Cadarache to continue investigating the pending FCI issues. By this agreement, CEA became owner of the facility. The main objective of the KROTOS programme at CEA Cadarache is understanding the role of melt properties in steam explosion propagation and energetics and, in particular, steam explosion behaviour of prototypical corium melts. Possible influence of physicochemical processes on explosiveness will also be explored. Actually, analysis of alumina debris produced at Ispra have shown that formation of metastable phases and chemical reaction with water at high temperature may play a significant role in enhancing heat transfer to water in the explosion phase. In order to reach the objective, steam explosion experiments are performed in well characterised conditions for a large spectrum of conditions and melt compositions of interest for both in- and ex-vessel situations. A trigger is applied as a rule. Advanced technology and instrumentation is used to reduce uncertainties on initial conditions and characterise the various phases of an explosion, with emphasis on high energy X-ray cinematography to qualify pre-mixing. This advanced instrumentation will enable the measurement of detailed variables to consolidate the qualification of the FCI codes. The use of high energy X-rays made it necessary to construct a new building to house the facility and its components. The facility should newly become operative early 2005. Main improvements with respect to Ispra concern melt delivery, hydrogen measurement and X-ray imaging. Preliminary studies have demonstrated that identification of the pre-mixture-water interface and coherent melt jet core, and

  3. Radioactivity and radioprotection: the every day life in a nuclear installation. Press tour at CEA/GRENOBLE 18 november 1999; Radioactivite et radioprotection: la vie quotidienne dans une installation nucleaire. Voyage de presse au Centre CEA/CADARACHE 18 novembre 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-11-01

    In the framework of the public information, this paper gives a general information on the radioactivity and the radioprotection at the CEA/Cadarache center. A first part is devoted to a presentation of the radioactivity with definitions and radiation effects on the human being and the environment. An other part presents the radioprotection activities and regulations. The last part deals with specific activities of the CEA/Cadarache: the CASCAD installations for spent fuels storage, the LECA Laboratory for the Examination of Active Fuels and a dismantling installation for big irradiated objects. Historical aspects of the CEA/Cadarache are also provided. (A.L.B.)

  4. Radioactive waste storage at the CEA Centre in Cadarache; transfer from the -storage yard- to the CEDRA facility: an illustration of changes in the safety requirements; L'entreposage de dechets nucleaires sur le Centre CEA de Cadarache: du -Parc d'entreposage- vers l'installation CEDRA: une illustration de l'evolution des exigences de surete

    Energy Technology Data Exchange (ETDEWEB)

    Verrhiest-Leblanc, G. [Autorite de Surete Nucleaire, Chargee d' Affaires, 75 - Paris (France); Tord, Ch. [Autorite de Surete Nucleaire, adjoint au chef de la Division de Marseille, 75 - Paris (France)

    2011-02-15

    A lot of changes have been made to the nuclear waste storage and disposal strategy over the last few years thanks to technological progress and changes in the requirements applicable in the sector. In this article, the authors present a concrete example of the actions undertaken, at the request of the French Nuclear Safety Authority (ASN), by the CEA Centre at Cadarache, regarding the Cadarache Centre waste storage facility (BNI 56), a facility which was originally intended as a permanent repository for solid waste. Commissioned in 1969, BNI 56 is made up of various trenches and pits which no longer meet current ASN requirements. To clean up these trenches, a legacy from the past, now requires considerable resources and involves many problems, especially due to uncertainty surrounding the nature, activity levels, packaging and volume of this waste. ASN ensures that the CEA will fully assume its overriding responsibility in the matter and implement safe, rigorous and transparent management solutions for all the waste. The BNI 56 trenches are an ongoing and concrete example of the difficulties inherent in recovering waste from storage and dismantling former facilities the design of which failed to take such aspects into account. This waste is now being repackaged so that it can be stored at a new basic nuclear installation called CEDRA (packaging and storage of radioactive waste) which complies with the safety requirements currently in force. This facility, commissioned in 2006, is intended for the storage of Type B solid radioactive waste for a period of 50 years pending construction of a deep geological repository or long-term storage facility. (authors)

  5. ITER at Cadarache; ITER a Cadarache

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-06-15

    This public information document presents the ITER project (International Thermonuclear Experimental Reactor), the definition of the fusion, the international cooperation and the advantages of the project. It presents also the site of Cadarache, an appropriate scientifical and economical environment. The last part of the documentation recalls the historical aspect of the project and the today mobilization of all partners. (A.L.B.)

  6. Web software for the control and management of radiation protection devices in the Cadarache site; Application WEB pour le controle et la gestion des appareils de radioprotection sur le centre de Cadarache

    Energy Technology Data Exchange (ETDEWEB)

    Beltritti, F. [CEA Cadarache 13108 St Paul lez Durance Cedex (France)

    2010-07-01

    This series of slides presents how to use a new software dedicated to the management of the periodical controls that have to be performed on the equipment involved in radiation protection. This software is ready to be dispatched on the CEA site of Cadarache. This software gives information on: the device to be controlled, the controls that have to be performed, the procedures to follow to make the test, the equipment necessary for the test particularly the need for radioactive sources, the maintenance of the device, the previous measurements and in the end the device's conformity. An evaluation of the conformity of all the devices present in a building or an area or of a particular type can be easily obtained. (A.C.)

  7. The CEA and the alternative energies. Press tour 25 and 26 november 1999; Le CEA et les energies alternatives. Voyage de presse les 25 et 26 novembre 1999

    Energy Technology Data Exchange (ETDEWEB)

    Carola, G. [CEA/Grenoble, 38 (France); Ngo, Ch. [CEA, Dir. de la Strategie et de l' Evaluation, 75 - Paris (France); Mermilliod, N.; Serre-Combe, P. [CEA/Grenoble, Dir. des Technologies Avancees, DTA, 38 (France); Sanglan, P. [Air Liquide, 38 - Sassenage (France); De La Graviere, M. [CEA/Cadarache, 13 - Saint-Paul-lez-Durance (France); Dieudonne, O.; Malbranche, Ph. [CEA/Cadarache, Dir. des Reacteurs Nucleaires, DRN, 13 - Saint-Paul-lez-Durance (France)

    1999-11-01

    In the framework of the public information on the CEA center of Cadarache and Grenoble, a presentation of the researches concerning the alternative energies is proposed. The Cea is commissioned by the Public Authorities, to keep the nuclear option open and for the long-dated, to develop renewable energies. In this domain researches on fuel cells and photovoltaic solar energy are performed. The principle and the applications of the fuel cell and the photovoltaic are recalled to introduce the research programs and the partners. (A.L.B.)

  8. Influence of high-permeability discs in an axisymmetric model of the Cadarache dynamo experiment

    Science.gov (United States)

    Giesecke, A.; Nore, C.; Stefani, F.; Gerbeth, G.; Léorat, J.; Herreman, W.; Luddens, F.; Guermond, J.-L.

    2012-05-01

    Numerical simulations of the kinematic induction equation are performed on a model configuration of the Cadarache von-Kármán-sodium dynamo experiment. The effect of a localized axisymmetric distribution of relative permeability μr that represents soft iron material within the conducting fluid flow is investigated. The critical magnetic Reynolds number Rmc for dynamo action of the first non-axisymmetric mode roughly scales like Rmcμr - Rmc∞∝μ-1/2r, i.e. the threshold decreases as μr increases. This scaling law suggests a skin effect mechanism in the soft iron discs. More important with regard to the Cadarache dynamo experiment, we observe a purely toroidal axisymmetric mode localized in the high-permeability discs which becomes dominant for large μr. In this limit, the toroidal mode is close to the onset of dynamo action with a (negative) growth rate that is rather independent of the magnetic Reynolds number. We qualitatively explain this effect by paramagnetic pumping at the fluid/disc interface and propose a simplified model that quantitatively reproduces numerical results. The crucial role of the high-permeability discs in the mode selection in the Cadarache dynamo experiment cannot be inferred from computations using idealized pseudo-vacuum boundary conditions (H × n = 0).

  9. CEA Annual report 2007; CEA rapport annuel 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The CEA, a prominent player in research development and innovation, is active in three main domains: energy, health care and information technology, defense and security. This annual report presents the CEA activities for the year 2007 in these three main areas: science and technology working for nuclear deterrence and global security, the energies without greenhouse effect gases emission against the climatic change, researches in the information sciences and technologies for a better communication and health. The CEA safety, organization, communication and international relations are also presented. (A.L.B.)

  10. CEA sustainable development report 2007; CEA rapport developpement durable 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The CEA, a prominent player in research development and innovation, is active in three main domains: energy, health care and information technology, defense and security. This annual report presents the CEA activities in the domain of the sustainable development. The first part is devoted to the environment preservation policy (energy, water, air, chemistry, wastes, transport, buildings). The second part shows the dynamic governance in the domain of the risks management. The last part presents the CEA activities of research for the sustainable development. (A.L.B.)

  11. CEA financial report 2007; CEA rapport financier 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This document provides financial data on the CEA for the year 2007. The management report (budget, resources, expenditures) and the accounting are detailed. The main management events of the year 2007 are presented. (A.L.B.)

  12. Web application for the control and management of radioprotection equipment in the Cadarache centre; Application WEB pour le controle et la gestion des appareils de radioprotection sur le centre de Cadarache

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2010-07-01

    The author describes a web 2-type application which has been developed for the periodic calibration controls of radioprotection equipment in Cadarache. This application aims at offering an easy and immediate and even remote access to information, at selecting information with respect to uses (radioprotection department, administrator, and so on), at securing and safeguarding homogeneous data, at editing control statistics. The different functionalities are briefly presented with their displayed interface

  13. Use of integral experiments for the assessment of a new 235U IRSN-CEA evaluation

    Science.gov (United States)

    Ichou, Raphaëlle; Leclaire, Nicolas; Leal, Luiz; Haeck, Wim; Morillon, Benjamin; Romain, Pascal; Duarte, Helder

    2017-09-01

    The Working Party on International Nuclear Data Evaluation Co-operation (WPEC) subgroup 29 (SG 29) was established to investigate an issue with the 235U capture cross-section in the energy range from 0.1 to 2.25 keV, due to a possible overestimation of 10% or more. To improve the 235U capture crosssection, a new 235U evaluation has been proposed by the Institut de Radioprotection et de Sûreté Nucléaire (IRSN) and the CEA, mainly based on new time-of-flight 235U capture cross-section measurements and recent fission cross-section measurements performed at the n_TOF facility from CERN. IRSN and CEA Cadarache were in charge of the thermal to 2.25 keV energy range, whereas the CEA DIF was responsible of the high energy region. Integral experiments showing a strong 235U sensitivity are used to assess the new evaluation, using Monte-Carlo methods. The keff calculations were performed with the 5.D.1 beta version of the MORET 5 code, using the JEFF-3.2 library and the new 235U evaluation, as well as the JEFF-3.3T1 library in which the new 235U has been included. The benchmark selection allowed highlighting a significant improvement on keff due to the new 235U evaluation. The results of this data testing are presented here.

  14. Use of integral experiments for the assessment of a new 235U IRSN-CEA evaluation

    Directory of Open Access Journals (Sweden)

    Ichou Raphaëlle

    2017-01-01

    Full Text Available The Working Party on International Nuclear Data Evaluation Co-operation (WPEC subgroup 29 (SG 29 was established to investigate an issue with the 235U capture cross-section in the energy range from 0.1 to 2.25 keV, due to a possible overestimation of 10% or more. To improve the 235U capture crosssection, a new 235U evaluation has been proposed by the Institut de Radioprotection et de Sûreté Nucléaire (IRSN and the CEA, mainly based on new time-of-flight 235U capture cross-section measurements and recent fission cross-section measurements performed at the n_TOF facility from CERN. IRSN and CEA Cadarache were in charge of the thermal to 2.25 keV energy range, whereas the CEA DIF was responsible of the high energy region. Integral experiments showing a strong 235U sensitivity are used to assess the new evaluation, using Monte-Carlo methods. The keff calculations were performed with the 5.D.1 beta version of the MORET 5 code, using the JEFF-3.2 library and the new 235U evaluation, as well as the JEFF-3.3T1 library in which the new 235U has been included. The benchmark selection allowed highlighting a significant improvement on keff due to the new 235U evaluation. The results of this data testing are presented here.

  15. Scientific evaluation at the CEA; Evaluation scientifique au CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-11-01

    This report presents a statement of the scientific and technical activity of the French atomic energy commission (CEA) for the year 1998. This evaluation is made by external and independent experts and requires some specific dispositions for the nuclear protection and safety institute (IPSN) and for the direction of military applications (DAM). The report is divided into 5 parts dealing successively with: part 1 - the CEA, a public research organization (civil nuclear research, technology research and transfers, defence activities); the scientific and technical evaluation at the CEA (general framework, evaluation of the IPSN and DAM); part 2 - the scientific and technical councils (directions of fuel cycle, of nuclear reactors, and of advanced technologies); part 3 - the scientific councils (directions of matter and of life sciences); the nuclear protection and safety institute; the direction of military applications; part 4 - the corresponding members of the evaluation; part 5 - the list of scientific and technical councils and members. (J.S.)

  16. CEA 2005 annual report; CEA rapport annuel 2005

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This document is the 2005 activity report of the French atomic energy commission (CEA). The CEA is a main actor of nuclear research, development and innovation and is involved in three main domains: energy, defense/security, and information/health technologies thanks to high quality research works. With a manpower of 15000 researchers and collaborators with internationally acknowledged competences, the CEA is a driving force of industrial innovation and develops partnerships with French and European industries. It also warrants the perenniality of nuclear dissuasion. This report presents these different aspects of the CEA activities: 1 - defense-security: simulation program, opening to the scientific community, nuclear warheads, nuclear propulsion, cleansing of Rhone valley facilities, permanent monitoring of treaties respect, fight against terrorism; 2 - energy: optimization of the industrial park, advances in long lived radioactive wastes management, future nuclear systems, cleansing and dismantling integration, European nuclear energy research, new energy technologies; 3 - information and health technologies: major challenge of micro- and nano-technologies, key role of software technologies and complex systems; 4 - big research facilities opened to the scientific and industrial communities; 5 - scientific status: scientific evaluation process, prices and honors; 6 - programs support: revisited strategic control, confirmed simplification, active employment and training policy, teaching and training, technological valorization, international relations, communication, continuous quality approach, mastery of facilities safety, security, environmental control, a key-year for information systems. A financial report is attached to the document. (J.S.)

  17. CEA - Annual report 2006; CEA - Rapport annuel 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The CEA, a prominent player in research development and innovation, is active in 3 main areas: energy, health care and information technology and defense and security. This annual report presents the CEA activity for the year 2006 in these three main areas: Science and technology working for nuclear deterrence and global security (the simulation programs, the nuclear warheads, the nuclear propulsion, the decommissioning, the fighting against nuclear proliferation and monitoring international treaties, the global security); health and information technology (micro and nano technologies and systems); energy from nuclear fission and fusion and other technologies that do not emit greenhouse gases (progress for the nuclear industry, sustainable management of radioactive materials and waste, nuclear systems of the future, new energy technologies). (A.L.B.)

  18. INIS, CEA and nuclear terminology; INIS, CEA et terminologie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Surmont, J.; Brulet, C.; Constant, A.; Guille, N.; Le Blanc, A.; Mouffron, O.; Anguise, P.; Jouve, J.J

    2007-07-01

    This poster, prepared for the fifth edition of the meetings of scientific and technical information professionals (RPIST, Nancy (France)), presents, first, the INIS information system, its content and coverage, the French participation to this system and the role of the CEA-Saclay as France's official representative for this system. Then it presents the INIS thesaurus with its different levels as a terminological tool for the indexing of documents and for searching documents inside the database. Finally, the very first electronic version of the multilingual thesaurus is introduced. Several national INIS centres, including the CEA-Saclay, have contributed to the translation of lists of new terms and of forbidden terms (synonyms). (J.S.)

  19. Las Gramináceas

    Directory of Open Access Journals (Sweden)

    Robledo Emilio

    1939-08-01

    Full Text Available Las gramináceas son plantas conocidas desde la antigüedad más remota. Tan importantes son las gramináceas desde el punto de vista bromatológico, que los hombres pueden ser clasificados en comedores de trigo, de arroz, de maíz, de mijo, de sorgo, de tocusso, de tef, etc. El área de distribución de las gramíneas es inmensa: se las encuentra desde las orillas del mar y en las aguas dulces, hasta las nieves perpetuas; sólo en las aguas saladas desconocidas. En punto de tamaño, las hay desde unos centímetros hasta nuestra guadua gigantesca, de treinta y más metros de altura. Dicha distribución se halla en relación con el clima, pero también es influida por los hábitos de los pueblos, por la civilización, por el comercio o por otras circunstancias.

  20. Memoirs of a Cea veteran

    Energy Technology Data Exchange (ETDEWEB)

    Puill, A

    2001-07-01

    A brief account is given of the way in which nuclear energy has developed in France and elsewhere over the last fifty years: options developed by the French Atomic Energy Commission (CEA), naval propulsion, development of pressurised water reactors, MOX and thorium fuels. Afterwards, the prospectives for the 21. century will be discussed. Considering that natural resources are depleting while releases of both greenhouse gases and world population are increasing, an active energy policy will have to be implemented with due consideration for social equity and solidarity. It is in this context that the developed countries will have to give preference, beyond savings, to renewable sources of energy, including of course, nuclear energy. Nuclear energy can continue to develop in the long term, provided fast breeder technology is developed at some point. As far as transport is concerned, hydrogen technology, which is clean and renewable, is promising, provided it is generated by nuclear energy. (author)

  1. CEA SMAD 2016 Digitizer Evaluation.

    Energy Technology Data Exchange (ETDEWEB)

    Merchant, Bion J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-08-01

    Sandia National Laboratories has tested and evaluated an updated SMAD digitizer, developed by the French Alternative Energies and Atomic Energy Commission (CEA). The SMAD digitizers are intended to record sensor output for seismic and infrasound monitoring applications. The purpose of this digitizer evaluation is to measure the performance characteristics in such areas as power consumption, input impedance, sensitivity, full scale, self-noise, dynamic range, system noise, response, passband, and timing. The SMAD digitizers have been updated since their last evaluation by Sandia to improve their performance when recording at a sample rate of 20 Hz for infrasound applications and 100 Hz for hydro-acoustic seismic stations. This evaluation focuses primarily on the 20 Hz and 100 Hz sample rates. The SMAD digitizers are being evaluated for potential use in the International Monitoring System (IMS) of the Comprehensive Nuclear Test- Ban-Treaty Organization (CTBTO).

  2. Decontamination and dismantling at the CEA; L'assainissement et le demantelement au CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This document presents the dismantling policy at the CEA (French Research Center on the atomic energy), the financing of the decontamination and the dismantling, the regulatory framework, the knowledge and the technology developed at the CEA, the radiation protection, the environment monitoring and the installations. (A.L.B.)

  3. CEA and AREVA R and D on V/HTR fuel fabrication with the CAPRI experimental manufacturing line

    Energy Technology Data Exchange (ETDEWEB)

    Charollais, Francois; Fonquernie, Sophie; Perrais, Christophe [DEN/CAD/DEC/SPUA, CEA, Centre de Cadarache, F-13108 Saint Paul lez Durance (France); Perez, Marc [DRT/GRE/DTEN/S3ME, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble cedex 9 (France); Cellier, Francois [FRAMATOME ANP, 10, rue Juliette Recamier, F-69456 Lyon cedex (France); Vitali, Marie-Pierre [CERCA Romans, FRAMATOME ANP, 10, rue Juliette Recamier, F-69456 Lyon cedex (France)

    2006-07-01

    In the framework of the French V/HTR fuel development and qualification program, the Commissariat a l'Energie Atomique (CEA) and AREVA through its program called ANTARES (Areva New Technology for Advanced Reactor Energy Supply) conduct R and D projects covering the mastering of UO{sub 2} coated particle and fuel compact fabrication technology. To fulfill this task, a review of past knowledge, of existing technologies and a preliminary laboratory scale work program have been conducted with the aim of retrieving the know-how on HTR coated particle and compact manufacture: - The different stages of UO{sub 2} kernel fabrication GSP Sol-Gel process have been reviewed, reproduced and improved; - The experimental conditions for the chemical vapour deposition (CVD) of coatings have been defined on dummy kernels and development of innovative characterization methods has been carried out; - Former CERCA compacting process has been reviewed and updated. In parallel, an experimental manufacturing line for coated particles, named GAIA, and a compacting line based on former CERCA compacting experience have been designed, constructed and are in operation since early 2005 at CEA Cadarache and CERCA Romans, respectively. These two facilities constitute the CAPRI line (CEA and AREVA PRoduction Integrated line). The major objectives of the CAPRI line are: - to recover and validate past knowledge; - to permit the optimisation of reference fabrication processes for kernels and coatings and the investigation of alternative and innovative fuel design (UCO kernel, ZrC coating); - to test alternative compact process options; - to fabricate and characterize fuel required for irradiation and qualification purpose; - to specify needs for the fabrication of representative V/HTR TRISO fuel meeting industrial standards. This paper presents the progress status of the R and D conducted on V/HTR fuel particle and compact manufacture by mid 2005. (authors)

  4. CEA and AREVA R and D on HTR fuel fabrication and presentation of the CAPRI experimental manufacturing line

    Energy Technology Data Exchange (ETDEWEB)

    Charollais, Francois [CEA Cadarache, DEN/CAD/DEC/SPUA, Bat. 315, BP1, 13108 Saint Paul lez Durance (France)]. E-mail: francois.charollais@cea.fr; Fonquernie, Sophie [CEA Cadarache, DEN/CAD/DEC/SPUA, Bat. 315, BP1, 13108 Saint Paul lez Durance (France); Perrais, Christophe [CEA Cadarache, DEN/CAD/DEC/SPUA, Bat. 315, BP1, 13108 Saint Paul lez Durance (France); Perez, Marc [CEA Grenoble, DRT/GRE/DTEN/S3ME, 17 rue des Martyrs, 38054 Grenoble Cedex 9 (France); Dugne, Olivier [CEA Pierrelatte, DEN/VRH/DTEC/STCF/LMAC, BP 111, 26702 Pierrelatte (France); Cellier, Francois [Framatome ANP , Plants Sector, 10 rue Juliette Recamier, 69456 Lyon Cedex 06 (France); Harbonnier, Gerard [CERCA, BP 1114, 26104 Romans sur Isere Cedex (France); Vitali, Marie-Pierre [CERCA , BP 1114, 26104 Romans sur Isere Cedex (France)

    2006-03-15

    In the framework of the French V/HTR fuel development and qualification program, the Commissariat a l'Energie Atomique (CEA) and AREVA are conducting R and D projects covering the mastering of UO{sub 2} coated particle and fuel compact fabrication technology. To fulfill this task, a review of past knowledge, of existing technologies and a preliminary laboratory-scale work program have been conducted with the aim of retrieving the know-how on HTR coated particle and compact manufacture: - The different stages of UO{sub 2} kernel fabrication GSP process have been reviewed, reproduced and improved. - The experimental conditions for the chemical vapor deposition of coatings have been defined on dummy kernels and development of innovative characterization methods has been carried out.- Former CERCA compacting process has been reviewed and updated. In parallel, an experimental manufacturing line for coated particles, named GAIA, and a compacting line based on former CERCA compacting experience have been designed, constructed and are in operation since early 2005 at CEA Cadarache and CERCA Romans, respectively. These two facilities constitute the CAPRI line (CEA and AREVA PRoduction Integrated line). The major objectives of the CAPRI line are: - to recover and validate past knowledge, - to produce representative HTR TRISO fuel meeting industrial standards, - to permit the optimization of reference fabrication processes for kernels and coatings defined previously at a laboratory-scale and the investigation of alternative and innovative fuel design (UCO kernel, ZrC coating), - to test alternative compact process options and - to fabricate and characterize fuel required for irradiation and qualification purpose. This paper presents the status of progress of R and D conducted on HTR fuel particles and compact manufacture by early 2005 and the potential of the laboratory-scale HTR fuel CAPRI line.

  5. Latest achievements of CEA and AREVA NP on HTR fuel fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Charollais, Francois [CEA Cadarache, DEN/CAD/DEC/SPUA, Bat. 315, BP1, 13108 Saint Paul lez Durance (France)], E-mail: francois.charollais@cea.fr; Perrais, Christophe; Moulinier, Dominique [CEA Cadarache, DEN/CAD/DEC/SPUA, Bat. 315, BP1, 13108 Saint Paul lez Durance (France); Perez, Marc [CEA Grenoble, DRT/GRE/DTEN/S3ME, 17 rue des Martyrs, 38054 Grenoble Cedex 9 (France); Vitali, Marie-Pierre [CERCA, BP 1114, 26104 Romans sur Isere Cedex (France)

    2008-11-15

    Extensive research and development programs on the (Very) High Temperature gas cooled Reactor (V/HTR) are being conducted by many countries mainly promoted by the attractiveness of this concept and its capability for other applications than electricity production, such as high temperature process heat and cogeneration. In this international context, the Commissariat a l'Energie Atomique (CEA) and AREVA NP through its project called ANTARES (Areva New Technology for Advanced Reactor Energy Supply) conduct a V/HTR fuel development and qualification program, among which one major activity is dedicated to the mastering of the nuclear fuel fabrication technology. The fuel concept selected for this project is the compact design based on UO{sub 2} kernels and SiC coating. First laboratory-scale experiments were performed to recover the know-how of HTR-coated particles and fuel element manufacturing. The different stages of UO{sub 2} kernel fabrication by the Gel Supported Precipitation (GSP) process were reviewed and improved. Experimental conditions for the Chemical Vapour Deposition (CVD) of coatings have been defined on dummy kernels supported by a modelling approach of the CVD process. The compacting processes formerly used at CERCA were reviewed and updated. In order to support a future industrial manufacturing factory and to meet the next short-term challenge, which is the fabrication of coated particle batches that will be compacted for the first irradiation test scheduled in OSIRIS, a lab-scale experimental manufacturing facility, named CAPRI (CEA and AREVA PRoduction Integrated) line has been set up and is in operation since early 2005. The CAPRI line is composed of a manufacturing line for TRISO particles, named GAIA, located at CEA Cadarache, and a compacting line for fuel elements based at CERCA, AREVA NP Subsidiary, Romans. Since early 2005, many tests have been performed leading to a better understanding and optimization of coating particle and compact

  6. 1999 scientific evaluation at the CEA; L'evaluation scientifique 1999 au CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    This report presents a statement of the scientific and technical activity of the French atomic energy commission (CEA) for the year 1999. This evaluation is made by external and independent experts and requires some specific dispositions for the nuclear protection and safety institute (IPSN) and for the direction of military applications (DAM). The report is divided into 4 parts dealing successively with: 1)the CEA, a public research organization (strategy, research programs, new organization of the CEA activities, civil nuclear research, technology research and transfer, defence activities, transfer of knowledge) 2)the scientific evaluation at the CEA (evaluations of the civil applications of the CEA, IPSN, DAM, INSTN (national institute for nuclear sciences and techniques) 3)synthesis of the 1999 scientific and technical evaluation for each operational directions of the CEA (directions of fuel cycle, of nuclear reactors, of advanced technologies, of materials sciences, of life sciences, of military applications, of the nuclear protection and safety institute and of the national institute for nuclear sciences and techniques) 4)the corresponding members of the evaluation and the list of scientific and technical councils and members.

  7. The CEA's waste management strategy; La strategie de gestion des dechets du CEA

    Energy Technology Data Exchange (ETDEWEB)

    Behar, Ch. [CEA Saclay, Dir. de l' Energie Nucleaire, 91 - Gif-sur-Yvette (France); Dall' ava, D. [CEA Saclay, Dir. de l' assainissement et du demantelement nucleaire, 91 - Gif-sur-Yvette (France); Fillion, E. [CEA Fontenay-aux-Roses, Direction de la protection et de la surete nucleaire, 92 (France)

    2011-02-15

    The CEA is tasked with carrying out certain research activities: within the Military Applications Division (DAM), research is focused on the nuclear deterrence and, within the Nuclear Energy Division, on developing the industrial nuclear systems of the future and optimising existing nuclear systems in partnership with EDF and AREVA. These major research and development themes entail a need for nuclear research and support facilities which must be maintained at a high level of performance and safety and, also, constantly upgraded to handle the research activities and programmes for which they are used. The CEA strategy is based on the right packaging of the radioactive liquid or solid waste into a form required for its transport, storage or disposal. The Caraibes software allows an efficient traceability of the waste packages. Most of the radioactive effluent processing stations of CEA are being upgraded

  8. Report transparency and nuclear safety 2007 CEA Grenoble; Rapport transparence et securite nucleaire 2007 CEA Grenoble

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Grenoble for the year 2007. Since 2002 the Passage project aims to realize the decontamination and the dismantling of old nuclear installations of the CEA Grenoble. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the year 2007 saw two main steps of the Passage project: the decommissioning of the Siloette reactor, a public consultation about the Lama laboratory dismantling. (A.L.B.)

  9. Press tour Siloe CEA/GRENOBLE; Voyage de presse Siloe CEA/GRENOBLE

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-04-01

    The experimental reactor, Siloe, has been stopped the 23 december 1997. This paper of the Cea Grenoble, presents the historical aspects of this reactor and its missions. It gives then a global description of the stopping and dismantling procedure, with the planning, the financing and the human impacts of the operation. The wastes management is also takes into account. (A.L.B.)

  10. Cutoff Values of Serum Carcinoembryonic Antigen (CEA) in Normal Korean Adults and Factors Influencing Serum CEA Level

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jong Soon [Hanil Hospital, Seoul (Korea, Republic of); Kim, Sun Wook; Chung, June Key; Lee, Dong Soo [Seoul National University Hospital, Seoul (Korea, Republic of)

    1994-10-15

    Carcinoembryonic Antigen is one of most frequently checked tumor markers in cancer management. We performed statistical analysis with serum CEA data of 2626 persons who received regular health examination and were thought to be free of active disease to determine the cutoff values of serum CEA level in normal Korean adults and to study the factors influencing serum CEA levels in normal subjects. 1) The cutoff values of serum CEA in normal Korean adults in general were 9.28 ng/ml for men, 5.90 ng/ml for women. 2) Serum CEA level was influenced by age, present smoking history, sex, and abnormal findings in chest X ray. 3) Serum CEA level had no correlation with the history of amount of alcohol consumption or obesity. 4) Cutoff values of serum CEA in normal Korean adults were tabulated according to age, sex, and smoking history. Serum CEA level was influenced by age, sex, present smoking history and abnormal findings in chest X ray and cutoff values of serum CEA were tabulated according to age, sex, and smoking history.

  11. Simplifying CEA through Excel, VBA, and Subeq

    Science.gov (United States)

    Foster, Ryan

    2004-01-01

    Many people use compound equilibrium programs for very different reasons, varying from refrigerators to light bulbs to rockets. A commonly used equilibrium program is CEA. CEA can take various inputs such as pressure, temperature, and volume along with numerous reactants and run them through equilibrium equations to obtain valuable output information, including products formed and their relative amounts. A little over a year ago, Bonnie McBride created the program subeq with the goal to simplify the calling of CEA. Subeq was also designed to be called by other programs, including Excel, through the use of Visual Basic for Applications (VBA). The largest advantage of using Excel is that it allows the user to input the information in a colorful and user-friendly environment while allowing VBA to run subeq, which is in the form of a FORTRAN DLL (Dynamic Link Library). Calling subeq in this form makes it much faster than if it were converted to VBA. Since subeq requires such large lists of reactant and product names, all of which can't be passed in as an array, subeq had to be changed to accept very long strings of reactants and products. To pass this string and adjust the transfer of input and output parameters, the subeq DLL had to be changed. One program that does this is Compaq Visual FORTRAN, which allows DLLs to be edited, debugged, and compiled. Compaq Visual FORTRAN uses FORTRAN 90/95, which has additional features to that of FORTRAN 77. My goals this summer include finishing up the excel spreadsheet of subeq, which I started last summer, and putting it on the Internet so that others can use it without having to download my spreadsheet. To finish up the spreadsheet I will need to work on debugging current options and problems. I will also work on making it as robust as possible, so that all errors that may arise will be clearly communicated to the user. New features will be added old ones will be changed as I receive comments from people using the spreadsheet

  12. Marantáceas Nuevas de Colombia

    Directory of Open Access Journals (Sweden)

    Smith Lyman B.

    1948-06-01

    Full Text Available Identificando numeroso material botánico en el United States National Herbarium, hemos hallado varias especies de la familia Marantaceae, especialmente de Colombia, que todavía no han sido descritas. No intentamos tratar sobre todas ellas en el presente trabajo, sino que nos limitamos a describir las más notables, dejando las demás para un estudio posterior, cuando se disponga de material más completo. Para poder entender con exactitud la estructura de las brácteas menores, así como de los pétalos y el androceo de estas plantas, no obstante lo mucho que se puede averiguar con ejemplares secos de herbario, es necesario que las observaciones se hagan sobre material vivo. La necesidad de estudiar en vivo las Marantáceas es mayor que En la gran mayoría de las familias que componen las Fanerógamas.

  13. On the Possibility of a Bridge between CBA and CEA

    DEFF Research Database (Denmark)

    Olai Hansen, Bodil; Hougaard, Jens Leth; Keiding, Hans

    In a recent work by Dolan and Edlin, it is concluded that no link can be established between cost-benefit analysis (CBA) and cost-effectiveness analysis (CEA). However, the conclusion seems to depend rather heavily on what is understood by a link between CBA and CEA as well as on the exact meaning...

  14. Carcinoembryonic antigen (CEA) as tumor marker in lung cancer

    DEFF Research Database (Denmark)

    Knudsen, Mie Grunnet; Sorensen, J B

    2012-01-01

    The use of CEA as a prognostic and predictive marker in patients with lung cancer is widely debated. The aim of this review was to evaluate the results from studies made on this subject. Using the search words "CEA", "tumor markers in lung cancer", "prognostic significance", "diagnostic...... and risk of death measured over time. No studies found CEA levels useful as a diagnostic marker for lung cancer. With regard to NSCLC the level of CEA measured in tumor tissue in NSCLC patients, were not of prognostic, diagnostic or predictive significance for OS or recurrence after treatment. In one study...... significance" and "predictive significance", a search was carried out on PubMed. Exclusion criteria was articles never published in English, articles before 1981 and articles evaluating tumor markers in lung cancer not involving CEA. Initially 217 articles were found, and 34 were left after selecting those...

  15. Report transparency and nuclear safety 2007 CEA Marcoule; Rapport transparence et securite nucleaire 2007 CEA Marcoule

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Marcoule for the year 2007. Since its creation in 1955 the center realizes industrial and scientific activities relative to the civil and military applications of the radioactivity. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the following two base activities are detailed: Atalante and Phenix. (A.L.B.)

  16. Report transparency and nuclear safety 2007 CEA Saclay; Rapport transparence et securite nucleaire 2007 CEA Saclay

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Saclay for the year 2007. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially two public consultation on release authorizations and the Neurospin installations, the dismantling of the 49 nuclear installation, the shutdown of the learning reactor ULYSSE are detailed. (A.L.B.)

  17. Demodicidosis en pacientes con rosácea

    Directory of Open Access Journals (Sweden)

    Edhizon Trejo Mucha

    2007-01-01

    Full Text Available Objetivo: Determinar la frecuencia de demodicidosis y sus características clínicas en pacientes con rosácea. Materiales y métodos: Estudio de casos y controles en 42 pacientes con rosácea y 42 controles para describir la presencia y densidad de D. folliculorum. El estudio se realizó en el Hospital Nacional Cayetano Heredia entre marzo y setiembre del 2004, utilizándose la técnica de Tello. Resultados: Demodex folliculorum fue encontrado en los 42 pacientes con rosácea (100% y en 13 (31,0% del grupo control, (p= 0,000. La exposición a gatos, la crianza de roedores y cerdos, la seborrea y el uso de corticoides tópicos fueron mas frecuentes en los pacientes con rosácea. Conclusiones: La presencia de Demodex folliculorum fue más frecuente en los pacientes con rosácea. (Rev Med Hered 2007;18:15-21.

  18. 2nd CEAS Specialist Conference on Guidance, Navigation and Control

    CERN Document Server

    Mulder, Bob; Choukroun, Daniel; Kampen, Erik-Jan; Visser, Coen; Looye, Gertjan

    2013-01-01

    Following the successful 1st CEAS (Council of European Aerospace Societies) Specialist Conference on Guidance, Navigation and Control (CEAS EuroGNC) held in Munich, Germany in 2011, Delft University of Technology happily accepted the invitation of organizing the 2nd  CEAS EuroGNC in Delft, The Netherlands in 2013. The goal of the conference is to promote new advances in aerospace GNC theory and technologies for enhancing safety, survivability, efficiency, performance, autonomy and intelligence of aerospace systems using on-board sensing, computing and systems. A great push for new developments in GNC are the ever higher safety and sustainability requirements in aviation. Impressive progress was made in new research fields such as sensor and actuator fault detection and diagnosis, reconfigurable and fault tolerant flight control, online safe flight envelop prediction and protection, online global aerodynamic model identification, online global optimization and flight upset recovery. All of these challenges de...

  19. CEA 2011, a look back at a year of research

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    For this year 2011, marked by the Fukushima accident, the goal is improved safety. This is a key issue being addressed by CEA, while at the same time boosting its R and D on low-carbon energies, defense and security, Health technologies, information technologies and very large research Infrastructures. With more than 650 priority patents filed in 2011, CEA maintains its position as the leading French research organization. CEA stands in 4. place among the European research organizations, in terms of the number of projects (535, including 70 that it coordinates) and financing obtained (nearly euros 55 M) under the European Commission's FP7 framework programme. CEA's civil programs are 30% funded from external revenues (partner companies, national incentive funds, local authorities and European Union), 49% from the Government and, finally, 21% from two funds dedicated to clean-up of civil and defense facilities. Of the euros 1, 391 M devoted to low-carbon energies, research into the new energy technologies and nuclear systems of the future each received a budget of euros 151 M in 2011. CEA plays a key role in the European Energy Research Alliance, as a founding member, a member of the executive committee and a member of the secretariat. It is France's representative. EERA has launched 13 joint programs, including 6 in 2011. It pools the research efforts of more than 150 institutes and universities, with more than 2, 000 staff employed full-time. CEA is present in 8 programs, with 100 full-time staff, in other words 5% of the total partner commitment. This special issue of 'Defis du CEA' journal deals with the main results of the researches carried out in 2011 at the CEA. Contents: 1 - Facts and figures 2011: Intellectual Property, European Financing, Budget, Nuclear Safety, European Research Programs, International Relations, International Collaboration, Spin-off, Scientific Excellence, Training; 2 - Low-carbon energies: Biofuels, Solar

  20. Aprovechamiento tradicional de cactáceas y agaváceas en los municipios de Tepeyahualco de Cuauhtémoc y Huitziltepec, Puebla

    OpenAIRE

    Martínez Vásquez, Esteban

    2012-01-01

    Las cactáceas y agaváceas son dos familias botánicas de gran importancia por el número de especies que presentan, y por los múltiples usos que han tenido entre la población de México. En los municipios de Tepeyahualco de Cuauhtémoc y Huitziltepec, diversas especies de cactáceas y agaváceas se han utilizado desde tiempos inmemoriales, con lo que se han generado importantes conocimientos sobre su manejo, producción y reproducción, aunque en la actualidad existen factores que están interfiriend...

  1. Annual report of the Association EURATOM/Cea

    Energy Technology Data Exchange (ETDEWEB)

    Magaud, Ph.; Le Vagueres, F

    2002-07-01

    This annual report presents research activities, which have been performed in 2002 by the French EURATOM-Cea association in the frame of the European technology program. The first section describes EFDA (European fusion development agreement) activities and related developments carried out by the association. The second one is dedicated to the underlying technology program and finally the third one presents the inertial confinement fusion activities. In each section the tasks are sorted out according to the EFDA main fields: physics (heating and current drive, remote participation, diagnostics), vessel/in-vessel (vessel/blanket, plasma facing components, remote handling), magnet, tritium breeding and materials (water cooled lithium lead blanket, helium cooled pebble bed blanket, helium cooled lithium lead blanket, reduced activation ferritic martensitic steels, advanced materials, neutron source, fuel cycle), safety and environment, system studies (power plant conceptual studies, socio-economic studies) and JET technology activities. The EURATOM-Cea association is involved in all these studies.

  2. Innovaciones en el agrodesarrollo de las cactáceas

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Padrón Pereira

    2012-01-01

    Full Text Available La globalización de los mercados ofrece nuevas oportunidades de desarrollo del campo en especial a recursos subutilizados en algunos países como las cactáceas, debido en parte a que, en cada país, los modelos culturales y de cultivo son diferentes. El cambio climático está generando nuevas dinámicas en dichos modelos que pueden llegar a ser sostenibles o disruptivas y las cáctaceas se presentan en ciertos aspectos como alternativas para la sustentabilidad de algunos sistemas; aunque también pueden verse afectadas. Lo expresado genera estudios diversos y en distintas especialidades. En este trabajo se presenta una recopilación de información existente y actualizada sobre temas relacionados con el aprovechamiento, la morfoanatomía, la germinación y desarrollo de las cactáceas, el cultivo in vitro, como también aspectos relativos a parámetros fisicoquímicos, la poscosecha y una reseña sobre cactáceas epífitas y/o trepadoras, las menos estudiadas.

  3. Innovaciones en el agrodesarrollo de las cactáceas

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Padrón Pereira

    2012-06-01

    Full Text Available La globalización de los mercados ofrece nuevas oportunidades de desarrollo del campo en especial a recursos subutilizados en algunos países como las cactáceas, debido en parte a que, en cada país, los modelos culturales y de cultivo son diferentes. El cambio climático está generando nuevas dinámicas en dichos modelos que pueden llegar a ser sostenibles o disruptivas y las cáctaceas se presentan en ciertos aspectos como alternativas para la sustentabilidad de algunos sistemas; aunque también pueden verse afectadas. Lo expresado genera estudios diversos y en distintas especialidades. En este trabajo se presenta una recopilación de información existente y actualizada sobre temas relacionados con el aprovechamiento, la morfoanatomía, la germinación y desarrollo de las cactáceas, el cultivo in vitro, como también aspectos relativos a parámetros fisicoquímicos, la poscosecha y una reseña sobre cactáceas epífitas y/o trepadoras, las menos estudiadas.

  4. Innovaciones en el agrodesarrollo de las cactáceas

    OpenAIRE

    Carlos Alberto Padrón Pereira

    2012-01-01

    La globalización de los mercados ofrece nuevas oportunidades de desarrollo del campo en especial a recursos subutilizados en algunos países como las cactáceas, debido en parte a que, en cada país, los modelos culturales y de cultivo son diferentes. El cambio climático está generando nuevas dinámicas en dichos modelos que pueden llegar a ser sostenibles o disruptivas y las cáctaceas se presentan en ciertos aspectos como alternativas para la sustentabilidad de algunos sistemas; aunque también p...

  5. Sensitivitas Dan Spesifisitas Pemeriksaan CEA Cairan Pleura Dalam Diagnosis Efusi Pleura Ganas Karena Kanker Paru

    OpenAIRE

    Arbaningsih, Sri Rezeki

    2011-01-01

    Tujuan : Mengetahui sensitivitas dan spesifisitas pemeriksaan CEA cairan pleura dalam menentukan suatu EPG karena kanker paru Metode : uji diagnostik secara observasional (cross sectional study). Hasil : Rerata hasil CEA cairan pleura pada kelompok efusi pleura ganas kanker paru 799,83 ± 1481,05 ng/ml, dan pada kelompok efusi pleura eksudatif bukan kanker 2,3 ± 4,2 ng/ml. Dengan berdasarkan peninggian kadar CEA cairan pleura diatas nilai normal > 5 ng/ml, maka didapatkan sensitivitas 62...

  6. Recurrent carotid stenosis after CEA and CAS: diagnosis and management.

    Science.gov (United States)

    Lal, Brajesh K

    2007-12-01

    Carotid endarterectomy (CEA) is the preferred method for cerebral revascularization in patients with symptomatic and asymptomatic high-grade extracranial carotid artery stenosis. Carotid artery stenting (CAS) has recently emerged as a less invasive alternative to endarterectomy. Carotid stenting has been demonstrated to be technically feasible and safe in high-risk patients. It has been approved as an acceptable method for revascularization in circumstances where CEA yields suboptimal results. While the final role of CAS in carotid revascularization will be determined on the basis of ongoing randomized trials, it is clear that stenting will continue to be performed in subgroups of patients with carotid stenosis. Therefore, it is anticipated that there will be a corresponding increase in the number of in-stent restenosis cases. Considerable controversy exists regarding the clinical significance, natural history, threshold for management, and appropriate intervention of recurrent carotid stenosis after endarterectomy and after stenting. This review analyzes current information on this important clinical problem and presents evidence-based recommendations for the diagnosis and management of recurrent carotid stenosis.

  7. 3rd CEAS Specialist Conference on Guidance, Navigation and Control

    CERN Document Server

    Drouin, Antoine; Roos, Clément

    2015-01-01

    The two first CEAS (Council of European Aerospace Societies) Specialist Conferences on Guidance, Navigation and Control (CEAS EuroGNC) were held in Munich, Germany in 2011 and in Delft, The Netherlands in 2013. ONERA The French Aerospace Lab, ISAE (Institut Supérieur de l’Aéronautique et de l’Espace) and ENAC (Ecole Nationale de l’Aviation Civile) accepted the challenge of jointly organizing the 3rd edition. The conference aims at promoting new advances in aerospace GNC theory and technologies for enhancing safety, survivability, efficiency, performance, autonomy and intelligence of aerospace systems. It represents a unique forum for communication and information exchange between specialists in the fields of GNC systems design and operation, including air traffic management. This book contains the forty best papers and gives an interesting snapshot of the latest advances over the following topics: l  Control theory, analysis, and design l  Novel navigation, estimation, and tracking methods l  Aircr...

  8. A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors.

    Science.gov (United States)

    Bacac, Marina; Fauti, Tanja; Sam, Johannes; Colombetti, Sara; Weinzierl, Tina; Ouaret, Djamila; Bodmer, Walter; Lehmann, Steffi; Hofer, Thomas; Hosse, Ralf J; Moessner, Ekkehard; Ast, Oliver; Bruenker, Peter; Grau-Richards, Sandra; Schaller, Teilo; Seidl, Annette; Gerdes, Christian; Perro, Mario; Nicolini, Valeria; Steinhoff, Nathalie; Dudal, Sherri; Neumann, Sebastian; von Hirschheydt, Thomas; Jaeger, Christiane; Saro, Jose; Karanikas, Vaios; Klein, Christian; Umaña, Pablo

    2016-07-01

    CEA TCB is a novel IgG-based T-cell bispecific (TCB) antibody for the treatment of CEA-expressing solid tumors currently in phase I clinical trials (NCT02324257). Its format incorporates bivalent binding to CEA, a head-to-tail fusion of CEA- and CD3e-binding Fab domains and an engineered Fc region with completely abolished binding to FcγRs and C1q. The study provides novel mechanistic insights into the activity and mode of action of CEA TCB. CEA TCB activity was characterized on 110 cell lines in vitro and in xenograft tumor models in vivo using NOG mice engrafted with human peripheral blood mononuclear cells. Simultaneous binding of CEA TCB to tumor and T cells leads to formation of immunologic synapses, T-cell activation, secretion of cytotoxic granules, and tumor cell lysis. CEA TCB activity strongly correlates with CEA expression, with higher potency observed in highly CEA-expressing tumor cells and a threshold of approximately 10,000 CEA-binding sites/cell, which allows distinguishing between high- and low-CEA-expressing tumor and primary epithelial cells, respectively. Genetic factors do not affect CEA TCB activity confirming that CEA expression level is the strongest predictor of CEA TCB activity. In vivo, CEA TCB induces regression of CEA-expressing xenograft tumors with variable amounts of immune cell infiltrate, leads to increased frequency of activated T cells, and converts PD-L1 negative into PD-L1-positive tumors. CEA TCB is a novel generation TCB displaying potent antitumor activity; it is efficacious in poorly infiltrated tumors where it increases T-cell infiltration and generates a highly inflamed tumor microenvironment. Clin Cancer Res; 22(13); 3286-97. ©2016 AACR. ©2016 American Association for Cancer Research.

  9. Control of effluents and environmental surveillance of the CEA centres. 1997 status; Controle des rejets et surveillance de l'environnement des centres CEA. Bilan 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-06-01

    The environmental quality in the vicinity of CEA facilities is a major concern of the safety policy of the CEA. The aim of this document is to inform the public about the gaseous and liquids radioactive effluents released by the CEA centres under the permission of the ministry. It provides a status of the effluents and of the radioactivity levels measured near the CEA centres in 1997, using air, water, vegetation and milk samples. A comparison is made with the measurements performed during the 1993-1996 period. The data presented comes from the regulatory registers transmitted to the agency for the protection against ionizing radiations (OPRI) which belongs to the ministry of health. (J.S.)

  10. Scientific evaluation at the French Atomic Energy Commission (CEA). 2005-2006 annual report; L'evaluation scientifique au CEA. Rapport annuel 2005-2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This report aims at presenting the scientific evaluation activities carried out at the CEA during the years 2005-2006. The evaluation system is described in detail. It comprises two aspects: the evaluation of the scientific policy implemented by the scientific Council and by the visiting committee of the CEA, and the evaluation of the laboratories, performed by a pool of 36 scientific councils. The evaluation by external and independent parties is the key point of this system. This document makes a status of the evaluations performed in 2005 and 2006. It presents a synthesis of the conclusions of the evaluation authorities. The actions implemented by the CEA to take into consideration the recommendations are also reported with the improvements noticed. The two topics examined by the scientific Committee and by the visiting committee were dealing with the energy domain, which is a strategic issue for the CEA. The examination of the researches on future nuclear reactors and on new energy technologies have shown the major role played by the CEA in the recent advances in these domains. About 95% of the laboratories activity was examined during the 2002-2005 period. The richness of the remarks and recommendations made by the scientific councils should allow the CEA to improve the quality and relevance of its research works. The start-up of the 2006-2009 evaluation cycle has been the occasion to modify the evaluation of some research domains in order to take into account the evolution of programs. The evaluation system of the CEA is highly consistent with the AERES principles. Its implementation, adapted to each type of activity (fundamental research, applied research, technological developments) allows the CEA to follow up a permanent improvement approach. (J.S.)

  11. Summary 1998. Releases control and environment monitoring for the CEA Centers; Bilan 1998. Controle des rejets et surveillance de l'environnement des centres CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-01

    In the framework of its environmental policy, the CEA aims at reduce as weak as possible, in regards to the technological and economic needs, its activities impacts on the people and the environment. This paper contributes to the public information on the radioactive gaseous and liquid releases during the year 1998. It presents data on the releases and the radioactivity levels around the CEA sites and gathers the associated regulation and monitoring methods. (A.L.B.)

  12. Cryogenic turbulence test facilities at CEA/SBT

    Science.gov (United States)

    Rousset, B.; Baudet, C.; Bon Mardion, M.; Bourgoin, M.; Braslau, A.; Daviaud, F.; Diribarne, P.; Dubrulle, B.; Gagne, Y.; Gallet, B.; Gibert, M.; Girard, A.; Lehner, T.; Moukharski, I.; Sy, F.

    2015-12-01

    Recently, CEA Grenoble SBT has designed, built and tested three liquid helium facilities dedicated to turbulence studies. All these experiments can operate either in HeI or HeII within the same campaign. The three facilities utilize moving parts inside liquid helium. The SHREK experiment is a von Kármán swirling flow between 0.72 m diameter counterrotating disks equipped with blades. The HeJet facility is used to produce a liquid helium free jet inside a 0.200 m I.D., 0.47 m length stainless steel cylindrical testing chamber. The OGRES experiment consists of an optical cryostat equipped with a particle injection device and an oscillating grid. We detail specific techniques employed to accommodate these stringent specifications. Solutions for operating these facilities without bubbles nor boiling/cavitation are described. Control parameters as well as Reynolds number and temperature ranges are given.

  13. METABOLISMO ÁCIDO DE LAS CRASULÁCEAS

    Directory of Open Access Journals (Sweden)

    THOMAS DAVID GEYDAN

    2005-01-01

    Full Text Available Se presenta una revisión del metabolismo ácido de las Crasuláceas, caracterizado por la ocurrencia, actividad y plasticidad del mecanismo desde un punto de vista fisio- lógico, bioquímico y molecular, enmarcado por la presencia de las denominadas cuatro fases de dicho metabolismo y su repercusión y expresión por diversas restric- ciones hídricas a nivel ecológico. Se presentan las principales enzimas y metabolitos básicos para el funcionamiento del metabolismo CAM, así como su modo de acción y control celular. Finalmente, se muestra que la plasticidad fenotípica en patrones de expresión CAM se encuentra mediada por condiciones ambientales y por señaliza- ciones moleculares.

  14. Atualidades e perspectivas das Anonáceas no mundo

    Directory of Open Access Journals (Sweden)

    Abel Rebouças São José

    2014-01-01

    Full Text Available Várias espécies da família Annonaceae produzem frutos comestíveis cultivados em pomares comerciais ou coletados de forma extrativista, em diversas partes do mundo. O gênero Annona possui elevado número de espécies nativas, no entanto poucas produzem frutos comestíveis. Algumas são cultivadas comercialmente, outras são obtidas de forma extrativista. As principais anonáceas cultivadas no mundo são: Annona muricata, Annona squamosa e Annona cherimola, com destaque também para a atemoia (híbrido entre A. squamosa x A. cherimola. Economicamente, são importantes para muitos países da África, Ásia e também da América Central, do Norte e do Sul. Os principais países produtores são: Austrália, Chile, Espanha, Estados Unidos, Nova Zelândia e Israel para cherimólia; México, Brasil, Venezuela e Costa Rica para graviola; e Índia, Brasil, Tailândia, Filipinas e Cuba para pinha. A produtividade de frutos das anonáceas nos diversos países produtores é relativamente baixa, em função do uso inadequado de técnicas de manejo (irrigação, fertilização, podas, polinização, controle de insetos e enfermidades, etc.. No Brasil, os cultivos comerciais mais relevantes com anonáceas são: pinha (A. squamosa L., graviola (A. muricata L. e atemoia. O objetivo deste trabalho é apresentar a situação atual e as perspectivas para as anonáceas no Brasil e no mundo. O cultivo é caracteristicamente de pequenos agricultores, usando especialmente a mão de obra familiar. De um modo geral, esses cultivos apresentam relevância socioeconômica nos países que possuem produção comercial pela geração de emprego e renda, e vêm, recentemente, ganhando importância no mercado mundial, dada sua condição de fruta exótica e pela sua qualidade, dentre as quais o valor nutracêutico (vitaminas, antioxidantes e outras propriedades funcionais. A expansão do consumo e sua maior relevância no mercado mundial dependem de ações relativas

  15. 77 FR 47169 - Clearing Requirement Determination Under Section 2(h) of the CEA

    Science.gov (United States)

    2012-08-07

    ... Clearing Requirement Determination Under Section 2(h) of the CEA AGENCY: Commodity Futures Trading... to the Commission for a clearing requirement determination; (3) Commission initiated reviews of swaps....'' \\20\\ \\20\\ See section 2(h) of the CEA. A clearing requirement determination also may be initiated by...

  16. Levels of CEA among vinyl chloride and polyvinyl chloride exposed workers

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, H.A. (City Univ. of New York, NY); Snyder, J.; Lewinson, T.; Woo, C.; Lilis, R.; Selikoff, I.J

    1978-09-01

    In 1974, vinyl chloride exposed workers were found to have an increased risk of malignant disease (hemangiosarcoma of the liver). We have examined 1,147 workers exposed to vinyl chloride monomer in three VC/PVC polymerization plants, and 269 workers from a PVC extrusion plant manufacturing PVC textile leather, exposed to much lower concentrations of vinyl chloride. Included among the comprehensive clinical and laboratory studies conducted was the CEA titer. We obtained, respectively, 1,115 and 248 CEA titers. Multiple factors were demonstrated which affected the distribution of CEA titers. Cigarette use had the greatest effect, followed by history of specific past illnesses and alcohol intake history. After removing these possible confounding effects, the distribution of CEA titers among the polymerization workers was significantly different from the extrusion plant group and from an unexposed comparison group. Of the six job categories analyzed, only production and maintenance workers had CEA titer distributions significantly different from the comparison group and the extrusion workers. The investigation demonstrates that occupational exposures in VC/PVC polymerization plants can cause elevations in the CEA titers of otherwise healthy individuals. Prospective follow-up is necessary before conclusions can be drawn concerning the usefulness of the CEA titer as a predictive indicator of possible increased risk.

  17. Fusion technology. Annual report of the. Association Cea/EURATOM; Technologie de fusion.Rapport annuel de l`association CEA/Euratom

    Energy Technology Data Exchange (ETDEWEB)

    Magaud, P.; Le Vagueres, F.

    1996-12-31

    In 1996, the French EURATOM-CEA Association made significant contributions to the European technology programme. This work is compiled in this report as follows: the ITER CEA activities and related developments are described in the first section; blankets and material developments for DEMO, long term safety studies are summarised in the second part; the Underlying Technology activities are compiled in the third part of this report. In each section, the tasks are sorted out to respect the European presentation. For an easy reading, appendix 4 gives the list of tasks in alphabetical order with a page reference list. The CEA is in charge of the French Technology programme. Three specific organizational directions of the CEA, located on four sites (see appendix 5) are involves in this programme: Advanced Technologies Direction (DTA), for Material task; Nuclear Reactors Direction (DRN), for Blanket design, Neutronic problems, Safety tasks; Physical Sciences Direction (DSM) uses the competence of the Tore Supra team in the Magnet design and plasma Facing Component field. The CEA programme is completed by collaborations with Technicatome, COMEX-Nucleaire and Ecole Polytechnique. The breakdown of the programme by Directions is presented in figure 1. The allocation of tasks is given in appendix 2 and in appendix 3, the related publications. (author).

  18. Identification of CEA-interacting proteins in colon cancer cells and their changes in expression after irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Byong Chul [Colorectal Cancer Branch, Research Institute, National Cancer Center, Goyang (Korea, Republic of); Yeo, Seung Gu [Dept. of Radiation Oncology, Soonchunhyang University College of Medicine, Soonchunhyang University Hospital, Cheonan (Korea, Republic of)

    2017-09-15

    The serum carcinoembryonic antigen (CEA) level has been recognized as a prognostic factor in colorectal cancer, and associated with response of rectal cancer to radiotherapy. This study aimed to identify CEA-interacting proteins in colon cancer cells and observe post-irradiation changes in their expression. CEA expression in colon cancer cells was examined by Western blot analysis. Using an anti-CEA antibody or IgG as a negative control, immunoprecipitation was performed in colon cancer cell lysates. CEA and IgG immunoprecipitates were used for liquid chromatography–tandem mass spectrometry (LC-MS/MS) analysis. Proteins identified in the CEA immunoprecipitates but not in the IgG immunoprecipitates were selected as CEA-interacting proteins. After radiation treatment, changes in expression of CEA-interacting proteins were monitored by Western blot analysis. CEA expression was higher in SNU-81 cells compared with LoVo cells. The membrane localization of CEA limited the immunoprecipitation results and thus the number of CEA-interacting proteins identified. Only the Ras-related protein Rab-6B and lysozyme C were identified as CEA-interacting proteins in LoVo and SNU-81 cells, respectively. Lysozyme C was detected only in SNU-81, and CEA expression was differently regulated in two cell lines; it was down-regulated in LoVo but up-regulated in SNU-81 in radiation dosage-dependent manner. CEA-mediated radiation response appears to vary, depending on the characteristics of individual cancer cells. The lysozyme C and Rab subfamily proteins may play a role in the link between CEA and tumor response to radiation, although further studies are needed to clarify functional roles of the identified proteins.

  19. Nuclear. In China, the CEA asserts itself as a team leader; Nucleaire: en Chine, le CEA s'impose en meneur de jeu

    Energy Technology Data Exchange (ETDEWEB)

    Dupin, L.

    2011-03-15

    As the French government gave the CEA the responsibility of negotiating the nuclear French-Chinese nuclear strategic partnership, this article outlines the personality of the CEA's chairman, Bernard Bigot, but also the tensions which exist between the two main actors of the French nuclear industry, EDF and Areva, notably about their respective projects of development of a new reactor with China as far as EDF is concerned, and with Japan as far as Areva is concerned. In fact, China is asking France, not to build new reactors but to improve the performance and the safety in the existing ones

  20. OPR1000 CEA Withdrawal at Power Accident Analysis using the SPACE code

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Chang-Keun; Lee, Dong-Hyuk; Ha, Sang-Jun [KHNP CRI, Daejeon (Korea, Republic of)

    2016-10-15

    The code has been Verification (V and V) matrix prepared for the SPACE code as the second phase of the development. In this study, CEA withdrawal at power accident has been simulated using the SPACE code as one aspect of the V and V work. The results from this simulation were compared with results of the RETRAN code which was used to approval of methodology for safety analysis of OPR1000 from regulatory committee. The KNAP methodology is applied to OPR1000 CEA withdrawal at power accident analysis and the results are compared with those mentioned in OPR1000 results of RETRAN code. Although there is some difference in peak temperature and SG pressure, the results from RETRAN calculation show similar trends. Through this evaluation of a OPR1000 CEA withdrawal at power accident analysis using the SPACE code, it is concluded that the SPACE code has the capability to predict the system response caused by a CEA withdrawal at power accident.

  1. Escala de Afrontamiento del Estrés Académico (A-CEA)

    National Research Council Canada - National Science Library

    Isabel Piñeiro; Susana Rodríguez; Antonio Valle; Ramón G. Cabanach; María G. Gerpe

    2010-01-01

    ... (Escala de Afrontamiento del Cuestionario de Estrés académico, A-CEA), that allows to differentiate between social support, cognitive reappraisal and planning, can be a useful instrument in the university scope.

  2. Numerical Platon: A unified linear equation solver interface by CEA for solving open foe scientific applications

    Energy Technology Data Exchange (ETDEWEB)

    Secher, Bernard [French Atomic Energy Commission (CEA), Nuclear Energy Division (DEN) (France); CEA Saclay DM2S/SFME/LGLS, Bat. 454, F-91191 Gif-sur-Yvette Cedex (France)], E-mail: bsecher@cea.fr; Belliard, Michel [French Atomic Energy Commission (CEA), Nuclear Energy Division (DEN) (France); CEA Cadarache DER/SSTH/LMDL, Bat. 238, F-13108 Saint-Paul-lez-Durance Cedex (France); Calvin, Christophe [French Atomic Energy Commission (CEA), Nuclear Energy Division (DEN) (France); CEA Saclay DM2S/SERMA/LLPR, Bat. 470, F-91191 Gif-sur-Yvette Cedex (France)

    2009-01-15

    This paper describes a tool called 'Numerical Platon' developed by the French Atomic Energy Commission (CEA). It provides a freely available (GNU LGPL license) interface for coupling scientific computing applications to various freeware linear solver libraries (essentially PETSc, SuperLU and HyPre), together with some proprietary CEA solvers, for high-performance computers that may be used in industrial software written in various programming languages. This tool was developed as part of considerable efforts by the CEA Nuclear Energy Division in the past years to promote massively parallel software and on-shelf parallel tools to help develop new generation simulation codes. After the presentation of the package architecture and the available algorithms, we show examples of how Numerical Platon is used in sequential and parallel CEA codes. Comparing with in-house solvers, the gain in terms of increases in computation capacities or in terms of parallel performances is notable, without considerable extra development cost.

  3. Comparison of Ablation Predictions for Carbonaceous Materials Using CEA and JANAF-Based Species Thermodynamics

    Science.gov (United States)

    Milos, Frank S.

    2011-01-01

    In most previous work at NASA Ames Research Center, ablation predictions for carbonaceous materials were obtained using a species thermodynamics database developed by Aerotherm Corporation. This database is derived mostly from the JANAF thermochemical tables. However, the CEA thermodynamics database, also used by NASA, is considered more up to date. In this work, the FIAT code was modified to use CEA-based curve fits for species thermodynamics, then analyses using both the JANAF and CEA thermodynamics were performed for carbon and carbon phenolic materials over a range of test conditions. The ablation predictions are comparable at lower heat fluxes where the dominant mechanism is carbon oxidation. However, the predictions begin to diverge in the sublimation regime, with the CEA model predicting lower recession. The disagreement is more significant for carbon phenolic than for carbon, and this difference is attributed to hydrocarbon species that may contribute to the ablation rate.

  4. Diagnostic value of mesothelin in pleural fluids: comparison with CYFRA 21-1 and CEA.

    Science.gov (United States)

    Filiberti, Rosa; Parodi, Stefano; Libener, Roberta; Ivaldi, Giovanni Paolo; Canessa, Pier Aldo; Ugolini, Donatella; Bobbio, Barbara; Marroni, Paola

    2013-06-01

    CYFRA 21-1 and CEA have been applied for the differential diagnosis of malignant pleural mesothelioma (MPM). The soluble mesothelin-related peptide (SMRP) has been proposed as a specific marker for distinguishing MPM from benign diseases and other malignancies in pleural effusions (PEs). In this study, we evaluated the usefulness of SMRP in PEs in the detection of mesotheliomas by comparing it with that of CYFRA 21-1, CEA, and with cytological examination. One hundred and seventy-seven consecutive patients (57 MPM, 64 metastatic tumors, and 56 benign diseases) were evaluated using commercial tests. The performance of the markers was analyzed by standard ROC analysis methods, using the area under a ROC curve (AUC) as a measure of accuracy. CYFRA 21-1 better differentiated malignant from benign effusions. The corresponding area under the receiver operating characteristic curve was 0.87, while it was 0.74 for SMRP and 0.64 for CEA (p < 0.001). Conversely, SMRP differentiated MPM from all other PEs better than both CYFRA 21-1 and CEA (AUC = 0.84, 0.76, and 0.32, respectively, p = 0.003). Low levels of CEA were associated with a MPM diagnosis. The AUC for differentiating MPM from metastases was 0.81 for SMRP, 0.61 for CYFRA 21-1, and 0.20 for CEA (p < 0.001). In cases with negative or suspicious cytology, SMRP and CYFRA 21-1 identified 36/71 and 46/66 malignant PEs (29 and 31 MPM, respectively). Only 1 MPM showed a high CEA concentration. No single marker showed the best performance in any comparison. Results suggest that SMRP could improve CYFRA 21-1 and CEA accuracy in the differential diagnosis of MPM.

  5. ZKSCAN3 Facilitates Liver Metastasis of Colorectal Cancer Associated with CEA-expressing Tumor.

    Science.gov (United States)

    Kim, Chan Wook; Roh, Seon Ae; Tak, Ka Hee; Koh, Bo Min; Ha, Ye Jin; Cho, Dong-Hyung; Kim, Seon-Yong; Kim, Yong Sung; Kim, Jin Cheon

    2016-05-01

    Zinc finger with KRAB and SCAN domain 3 (ZKSCAN3) is overexpressed in invasive colorectal cancer (CRC) cells and regulates the expression of several genes favoring tumor progression, including vascular endothelial growth factor (VEGF) and integrin β4. We evaluated the association of ZKSCAN3 and colorectal cancer liver metastasis (CLM) to determine whether it is related to invasive signaling pathways. The ratios of expression by primary tumor to normal tissue and metastatic tumor to normal tissue were compared between ZKSCAN3-overexpressing and underexpressing primary tumor groups. In terms of CLM, the ZKSCAN3 overexpression was positively correlated with carcinoembryonic antigen (CEA), VEGF, and AKT expression. The protein-expression analysis showed that ZKSCAN-specific siRNA knockdown reduced CEA expression in LoVo and LS174T CRC cells. Matrigel invasion by ZKSCAN3-overexpressing HCT116 cells was increased when examined on CEA-coated filters compared with phosphate-buffered saline-treated controls. Additionally, matrix metalloproteinase 9 (MMP9) expression was greater in cells with reference allele (GG) than substitution allele (CC) for ZKSCAN3 rs733743 (p=0.032). ZKSCAN3 protein expression of the high serum CEA group was increased in hepatic metastatic tissue compared with the primary tumor tissue, while in the group with normal serum CEA it decreased or was similar. Reference ZKSCAN3 alleles were correlated with male dominance, a family history of malignancy, high serum CEA concentration and stage IV CRC in 450 patients with sporadic CRC. In conclusion, ZKSCAN3 appears to promote colorectal tumor progression and invasion. ZKSCAN3 may facilitate hepatic metastasis of CRC associated with CEA particularly in cases with CEA-producing tumor. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  6. Situation 2002: release monitoring and surveillance of environment of Cea centers; Bilan 2002: controle des rejets et surveillance de l'environnement des centres CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This publication renders an account of the situation of the releases of liquid and gaseous radioactive effluents, for the year 2002, as well as the radioactivity levels measured in the vicinity of Cea centers through the systematic surveillance of atmosphere, waters, vegetation and milk. An analysis on five years allows to follow their evolution. (N.C.)

  7. Melanoma cell surface-expressed phosphatidylserine as a therapeutic target for cationic anticancer peptide, temporin-1CEa.

    Science.gov (United States)

    Wang, Che; Chen, Yin-Wang; Zhang, Liang; Gong, Xian-Ge; Zhou, Yang; Shang, De-Jing

    2016-01-01

    We have previously reported that temporin-1CEa, a cationic antimicrobial peptide, exerts preferential cytotoxicity toward cancer cells. However, the exact molecular mechanism for this cancer-selectivity is still largely unknown. Here, we found that the negatively charged phosphatidylserine (PS) expressed on cancer cell surface serves as a target for temporin-1CEa. Our results indicate that human A375 melanoma cells express 50-fold more PS than non-cancerous HaCaT cells. The expression of cell surface PS in various cancer cell lines closely correlated with their ability to be recognized, bound and killed by temporin-1CEa. Additionally, the cytotoxicity of temporin-1CEa against A375 cells can be ameliorated by annexin V, which binds to cell surface PS with high affinity. Moreover, the data of isothermal titration calorimetry assay further confirmed a direct binding of temporin-1CEa to PS, at a ratio of 1:5 (temporin-1CEa:PS). Interestingly, the circular dichroism spectra analysis using artificial biomembrane revealed that PS not only provides electrostatic attractive sites for temporin-1CEa but also confers the membrane-bound temporin-1CEa to form α-helical structure, therefore, enhances the affinity and membrane disrupting ability of temporin-1CEa. In summary, these findings suggested that the melanoma cells expressed PS may serve as a promising target for temporin-1CEa or other cationic anticancer peptides.

  8. Fitoplancton del Parque Nacional Las Tablas de Daimiel. II. Las cianofíceas, los dinoflagelados, las criptofíceas, las crisofíceas y las xantofíceas

    Directory of Open Access Journals (Sweden)

    Rojo, Carmen

    1999-12-01

    Full Text Available Las Tablas de Daimiel National Park is a semiarid wetland that exhibits a high biodiversity but is suffering an inexorable eutrophication process. The study of the phytoplankton in this wetland is interesting because of its hydrological fluctuations (drought period until 1996 and its trophic condition. This papers shows the taxonomy, dynamic, and ecology of microalgae in five áreas of the Park from 1996 to 1998, which allow comparisons to be made between the present state and the 1992-1993 period. Twelve taxa of Cyanophyta, 4 of Dynophyceae, 8 of Cryptophyceae, 5 of Chrysophyceae and one of Xanthophyceae were found. Almost all species have been already cited in Spain and are typical for eutrophic environments. Cyanophyceae and Cryptophyceae were the most important groups (Planktothrix agardhii, Anabaenopsis elenkinii, Cryptomonas erosa as the most common algae. Moreover, oscillatorial Cyanophyceae (in 1992 have been replaced by N-fixing nostocal ones, related to the high level of pollution found in recent years.El Parque Nacional Las Tablas de Daimiel es un humedal semiárido, importante reserva de biodiversidad que, sin embargo, está sufriendo un inexorable proceso de eutrofización. Su estado trófico, así como los cambios hidrológicos (sequía hasta 1996, hacen especialmente interesante el estudio de su microflora. Por ello, se ha llevado a cabo este trabajo sobre las poblaciones fitoplanctónicas en cinco puntos del Parque desde 1996 a 1998, que permite además la comparación con su estado en 1992-1993. Se encontraron 12 táxones de Cyanophyta, 4 de Dynophyceae, 8 de Cryptophyceae, 5 de Chrysophyceae y uno de Xanthophyceae. Casi todas las especies están citadas en España y son propias de ambientes eutróficos. Los grupos mejor representados fueron las cianobacterias y criptofíceas (Planktothrix agardhii, Anabaenopsis elenkinii y Cryptomonas erosa fueron las especies más conspicuas. Además, se observa un cambio de cianobacterias

  9. Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines

    Science.gov (United States)

    Klein, Christian; Waldhauer, Inja; Nicolini, Valeria G.; Freimoser-Grundschober, Anne; Nayak, Tapan; Vugts, Danielle J.; Dunn, Claire; Bolijn, Marije; Benz, Jörg; Stihle, Martine; Lang, Sabine; Roemmele, Michaele; Hofer, Thomas; van Puijenbroek, Erwin; Moser, Samuel; Ast, Oliver; Brünker, Peter; Gorr, Ingo H.; Neumann, Sebastian; Hinton, Heather; Crameri, Flavio; Gerdes, Christian; Bacac, Marina; van Dongen, Guus; Moessner, Ekkehard; Umaña, Pablo

    2017-01-01

    ABSTRACT We developed cergutuzumab amunaleukin (CEA-IL2v, RG7813), a novel monomeric CEA-targeted immunocytokine, that comprises a single IL-2 variant (IL2v) moiety with abolished CD25 binding, fused to the C-terminus of a high affinity, bivalent carcinoembryonic antigen (CEA)-specific antibody devoid of Fc-mediated effector functions. Its molecular design aims to (i) avoid preferential activation of regulatory T-cells vs. immune effector cells by removing CD25 binding; (ii) increase the therapeutic index of IL-2 therapy by (a) preferential retention at the tumor by having a lower dissociation rate from CEA-expressing cancer cells vs. IL-2R-expressing cells, (b) avoiding any FcγR-binding and Fc effector functions and (c) reduced binding to endothelial cells expressing CD25; and (iii) improve the pharmacokinetics, and thus convenience of administration, of IL-2. The crystal structure of the IL2v-IL-2Rβγ complex was determined and CEA-IL2v activity was assessed using human immune effector cells. Tumor targeting was investigated in tumor-bearing mice using 89Zr-labeled CEA-IL2v. Efficacy studies were performed in (a) syngeneic mouse models as monotherapy and combined with anti-PD-L1, and in (b) xenograft mouse models in combination with ADCC-mediating antibodies. CEA-IL2v binds to CEA with pM avidity but not to CD25, and consequently did not preferentially activate Tregs. In vivo, CEA-IL2v demonstrated superior pharmacokinetics and tumor targeting compared with a wild-type IL-2-based CEA immunocytokine (CEA-IL2wt). CEA-IL2v strongly expanded NK and CD8+ T cells, skewing the CD8+:CD4+ ratio toward CD8+ T cells both in the periphery and in the tumor, and mediated single agent efficacy in syngeneic MC38-CEA and PancO2-CEA models. Combination with trastuzumab, cetuximab and imgatuzumab, all of human IgG1 isotype, resulted in superior efficacy compared with the monotherapies alone. Combined with anti-PD-L1, CEA-IL2v mediated superior efficacy over the respective

  10. How to Add Value to your Business with CEA: A Practical Approach

    Directory of Open Access Journals (Sweden)

    Daniel Cardenas

    2010-04-01

    Full Text Available Companies are always trying to differentiate themselves from the rest of the pack by applying different strategies such as improving customer service, increasing the efficiency of their operations, or reducing their costs. Most of the time, however, these goals are competing against each other for scarce resources, and managers often need to decide to concentrate on one. A small company can effectively and simultaneously accomplish these goals for a fraction of the cost by implementing communications-enabled business processes or solutions, which are a set of technology components that add real-time networking functionality to applications. One particular implementation of this framework is the one provided by Coral CEA. Coral CEA is a business ecosystem anchored around CEA functionalities that are offered as building blocks, out-of-the-box components that link the capabilities and intelligence of networks platforms with the power of current applications to provide a new set of features and functionalities. In this article, we show how a small company called Rezact, located in the ski resort town of Mont-Tremblant, Quebec, successfully implemented CEA capabilities within its own operations using Coral CEA services.

  11. A three-dimensional pin-wise analysis for CEA ejection accident

    Energy Technology Data Exchange (ETDEWEB)

    Park, Guen-Tae; Park, Min-Ho; Park, Jin-Woo; Um, Kil-Sup; Choi, Tong-Soo [KEPCO NF, Daejeon (Korea, Republic of)

    2016-10-15

    The ejection of a control element assembly (CEA) with high reactivity worth causes the sudden insertion of reactivity into the core. Immediately after the CEA ejection, the nuclear power of the reactor dramatically increases in an exponential behavior until the doppler effect becomes important and turns the reactivity balance and power down to lower levels. The 3-D CEA ejection analysis methodology has been developed using the multi-dimensional code coupling system, CHASER, which couples three dimensional core neutron kinetics code ASTRA, subchannel analysis code THALES, and fuel performance analysis code FROST using message passing interface (MPI). This paper presents the pin-by-pin level analysis result with the 3-D CEA ejection analysis methodology using the CHASER. The pin-by-pin level analysis consists of DNBR, enthalpy and Pellet/Clad Mechanical Interaction (PCMI) analysis. All the evaluations are simulated for APR1400 plant loaded with PLUS7 fuel. In this paper, the pin-by-pin analysis using the multidimensional core transient code, CHASER, is presented with respect to enthalpy, DNBR and PCMI for APR1400 plant loaded with PLUS7 fuel. For the pin-by-pin enthalpy and DNBR analysis, the quarter core for HFP case or 15 - 20 assemblies around the most severe assembly for part powers or HZP cases are selected. And PCMI calculation is performed for all the rods in the whole core during a conservative time period. The pin-by-pin analysis results show that the regulatory guidelines of CEA ejection accident are satisfied.

  12. Understanding Harris' understanding of CEA: is cost effective resource allocation undone?

    Science.gov (United States)

    Edlin, Richard; McCabe, Christopher; Round, Jeff; Wright, Judy; Claxton, Karl; Sculpher, Mark; Cookson, Richard

    2013-01-01

    We summarise and evaluate Harris' criticisms of cost-effectiveness analysis (CEA) and the alternative processes he commends to health care decision makers. In contrast to CEA, Harris' asserts that individuals have a right to life-saving treatment that cannot be denied on the basis of their capacity to benefit. We conclude that, whilst Harris' work has challenged the proponents of CEA and quality-adjusted life years to be explicit about the method's indirect discriminatory characteristics, his arguments ignore important questions about what 'lives saved' mean. Harris also attempts to avoid opportunity cost by advocating the same chance of treatment for every person desiring treatment. Using a simple example, we illustrate that an 'equal chances' lottery is not in the interest of any patient, as it reduces the chance of treatment for all patients by leaving some of the health budget unspent.

  13. Updated on effluents releases of the CEA nuclear fuel cycle facilities - 1995 to 2010 period

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Nelson Luiz Dias [Centro Tecnologico da Marinha em Sao Paulo (CTMSP) Sao Paulo, SP (Brazil)

    2011-07-01

    The environmental impact assessment of the Centro Experimental Aramar (CEA) facilities has been presented in a former work, based on the measured effluent releases data, for the period from 1995 to 2007. This work shows the update up to 2010. The effluents releases to the environment result from the routine operation of CEA nuclear fuel cycle facilities (LEI - Isotopic Enrichment Laboratory, USIDE - Pilot Plant for Industrial Verification of Uranium Enrichment and LABMAT - Nuclear Materials Laboratory). Basically, this work presents the radioactive release source terms, as described at the CEA Effluent Report sent to the National Commission for Nuclear Energy (CNEN) each semester, and a historical assessment of the critical group annual doses from 1995 up to 2010. The assessed doses are compared to the maximum dose constraint as well as to the exemption level specified by CNEN. (author)

  14. Overview of CEA research in the field of radionuclides migration; Syntheses des recherches menees par le CEA sur la migration des radionucleides

    Energy Technology Data Exchange (ETDEWEB)

    Poinssot, Ch.; Trotignon, L.; Tevissen, E

    2006-07-01

    This report presents a synthetic status of the researches conducted within the Nuclear Energy Division (CEA/DEN) in the field of radionuclides migration in three specific areas which have been chosen for their representativeness and potential impact: the migration of RN in PWR reactors, the migration of RN from a deep geological repository and the migration processes in the surface environments. In addition, some status is given about more generic research which is conducted in the field of RN speciation in the aqueous phase and at the interfaces and regarding chemistry / transport couplings. Additional information about the human and technical means involved in these fields of research in CEA/DEN is finally given in the Appendix. (authors)

  15. Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa.

    Directory of Open Access Journals (Sweden)

    Petra Muenzner

    2016-05-01

    Full Text Available Attachment to the host mucosa is a key step in bacterial pathogenesis. On the apical surface of epithelial cells, members of the human carcinoembryonic antigen (CEA family are abundant glycoproteins involved in cell-cell adhesion and modulation of cell signaling. Interestingly, several gram-negative bacterial pathogens target these receptors by specialized adhesins. The prototype of a CEACAM-binding pathogen, Neisseria gonorrhoeae, utilizes colony opacity associated (Opa proteins to engage CEA, as well as the CEA-related cell adhesion molecules CEACAM1 and CEACAM6 on human epithelial cells. By heterologous expression of neisserial Opa proteins in non-pathogenic E. coli we find that the Opa protein-CEA interaction is sufficient to alter gene expression, to increase integrin activity and to promote matrix adhesion of infected cervical carcinoma cells and immortalized vaginal epithelial cells in vitro. These CEA-triggered events translate in suppression of exfoliation and improved colonization of the urogenital tract by Opa protein-expressing E. coli in CEA-transgenic compared to wildtype mice. Interestingly, uropathogenic E. coli expressing an unrelated CEACAM-binding protein of the Afa/Dr adhesin family recapitulate the in vitro and in vivo phenotype. In contrast, an isogenic strain lacking the CEACAM-binding adhesin shows reduced colonization and does not suppress epithelial exfoliation. These results demonstrate that engagement of human CEACAMs by distinct bacterial adhesins is sufficient to blunt exfoliation and to promote host infection. Our findings provide novel insight into mucosal colonization by a common UPEC pathotype and help to explain why human CEACAMs are a preferred epithelial target structure for diverse gram-negative bacteria to establish a foothold on the human mucosa.

  16. Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa

    Science.gov (United States)

    Muenzner, Petra; Kengmo Tchoupa, Arnaud; Klauser, Benedikt; Brunner, Thomas; Putze, Johannes; Dobrindt, Ulrich; Hauck, Christof R.

    2016-01-01

    Attachment to the host mucosa is a key step in bacterial pathogenesis. On the apical surface of epithelial cells, members of the human carcinoembryonic antigen (CEA) family are abundant glycoproteins involved in cell-cell adhesion and modulation of cell signaling. Interestingly, several gram-negative bacterial pathogens target these receptors by specialized adhesins. The prototype of a CEACAM-binding pathogen, Neisseria gonorrhoeae, utilizes colony opacity associated (Opa) proteins to engage CEA, as well as the CEA-related cell adhesion molecules CEACAM1 and CEACAM6 on human epithelial cells. By heterologous expression of neisserial Opa proteins in non-pathogenic E. coli we find that the Opa protein-CEA interaction is sufficient to alter gene expression, to increase integrin activity and to promote matrix adhesion of infected cervical carcinoma cells and immortalized vaginal epithelial cells in vitro. These CEA-triggered events translate in suppression of exfoliation and improved colonization of the urogenital tract by Opa protein-expressing E. coli in CEA-transgenic compared to wildtype mice. Interestingly, uropathogenic E. coli expressing an unrelated CEACAM-binding protein of the Afa/Dr adhesin family recapitulate the in vitro and in vivo phenotype. In contrast, an isogenic strain lacking the CEACAM-binding adhesin shows reduced colonization and does not suppress epithelial exfoliation. These results demonstrate that engagement of human CEACAMs by distinct bacterial adhesins is sufficient to blunt exfoliation and to promote host infection. Our findings provide novel insight into mucosal colonization by a common UPEC pathotype and help to explain why human CEACAMs are a preferred epithelial target structure for diverse gram-negative bacteria to establish a foothold on the human mucosa. PMID:27171273

  17. Report of transparency and nuclear safety 2007 CEA Fontenay aux Roses; Rapport transparence et securite nucleaire 2007 CEA Fontenay aux Roses

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Fontenay aux roses for the year 2007. After many years of decommissioning and dismantling of nuclear installations, the Center is now devoted (since 2005) to the development of research programmes on biology and biomedical technologies. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. (A.L.B.)

  18. General review of multispectral cooled IR development at CEA-Leti, France

    Science.gov (United States)

    Boulard, F.; Marmonier, F.; Grangier, C.; Adelmini, L.; Gravrand, O.; Ballet, P.; Baudry, X.; Baylet, J.; Badano, G.; Espiau de Lamaestre, R.; Bisotto, S.

    2017-02-01

    Multicolor detection capabilities, which bring information on the thermal and chemical composition of the scene, are desirable for advanced infrared (IR) imaging systems. This communication reviews intra and multiband solutions developed at CEA-Leti, from dual-band molecular beam epitaxy grown Mercury Cadmium Telluride (MCT) photodiodes to plasmon-enhanced multicolor IR detectors and backside pixelated filters. Spectral responses, quantum efficiency and detector noise performances, pros and cons regarding global system are discussed in regards to technology maturity, pixel pitch reduction, and affordability. From MWIR-LWIR large band to intra MWIR or LWIR bands peaked detection, results underline the full possibility developed at CEA-Leti.

  19. Aeroacoustics research in Europe: The CEAS-ASC report on 2003 highlights

    Science.gov (United States)

    Schröder, W.

    2004-11-01

    This is a report on some highlights of aeroacoustics research in Europe in 2003, compiled from information provided to the Aeroacoustics Specialists Committee of the Confederation of European Aerospace Societies (CEAS). The CEAS currently comprises the national Aerospace Societies of France (Association Aéronautique et Astronautique de France), Germany (Deutsche Gesellschaft für Luft- und Raumfahrt), Italy (Associazione Italiana di Aeronautica e Astronautica), The Netherlands (Nederlandse Vereniging voor Luchtvaarttechniek), Spain (Asociación de Ingenieros Aeronáuticos de España), Sweden (Flygtekniska Föreningen), Switzerland (Schweizerische Vereinigung für Flugwissenschaften) and the UK (The Royal Aeronautical Society).

  20. Assessment 2000 and regulation and method. Releases control and environmental survey of the CEA Centers; Bilan 2000 et reglementation et methode. Controle des rejets et surveillance de l'environnement des centres CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    The environment quality around the CEA centers is a major interest of its safety policy. These documents contribute to the public information on the radioactive liquid and gaseous releases of the CEA, according to the ministry authorization. The radioactivity monitoring activity, and the survey methods are also presented. Data analysis from 1996 to 2000, allows to follow the evolution. (A.L.B.)

  1. Use of a combination of CEA and tumor budding to identify high-risk patients with stage II colon cancer.

    Science.gov (United States)

    Du, Changzheng; Xue, Weicheng; Dou, Fangyuan; Peng, Yifan; Yao, Yunfeng; Zhao, Jun; Gu, Jin

    2017-07-24

    High-risk patients with stage II colon cancer may benefit from adjuvant chemotherapy, but identifying this patient population can be difficult. We assessed the prognosis value for predicting tumor progression in patients with stage II colon cancer, of a panel of 2 biomarkers for colon cancer: tumor budding and preoperative carcinoembryonic antigen (CEA). Consecutive patients (N = 134) with stage II colon cancer who underwent curative surgery from 2000 to 2007 were included. Multivariate analysis was used to evaluate the association of CEA and tumor budding grade with 5-year disease-free survival (DFS). The prognostic accuracy of CEA, tumor budding grade and the combination of both (CEA-budding panel) was determined. The study found that both CEA and tumor budding grade were associated with 5-year DFS. The prognostic accuracy for disease progression was higher for the CEA-budding panel (82.1%) than either CEA (70.9%) or tumor budding grade (72.4%) alone. The findings indicate that the combination of CEA levels and tumor budding grade has greater prognostic value for identifying patients with stage II colon cancer who are at high-risk for disease progression, than either marker alone.

  2. Sensitivity of CA 15-3, CEA and serum HER2 in the early detection of recurrence of breast cancer

    DEFF Research Database (Denmark)

    Eriksen, Ann Christina; Sørensen, Patricia Diana; Jacobsen, Erik Hugger

    2013-01-01

    The aim of this project was to investigate the sensitivity of CA 15-3, CEA and HER2 in the early diagnosis of metastatic breast cancer.......The aim of this project was to investigate the sensitivity of CA 15-3, CEA and HER2 in the early diagnosis of metastatic breast cancer....

  3. Mutational Profiles Reveal an Aberrant TGF-β-CEA Regulated Pathway in Colon Adenomas.

    Directory of Open Access Journals (Sweden)

    Jian Chen

    Full Text Available Mutational processes and signatures that drive early tumorigenesis are centrally important for early cancer prevention. Yet, to date, biomarkers and risk factors for polyps (adenomas that inordinately and rapidly develop into colon cancer remain poorly defined. Here, we describe surprisingly high mutational profiles through whole-genome sequence (WGS analysis in 2 of 4 pairs of benign colorectal adenoma tissue samples. Unsupervised hierarchical clustered transcriptomic analysis of a further 7 pairs of adenomas reveals distinct mutational signatures regardless of adenoma size. Transitional single nucleotide substitutions of C:G>T:A predominate in the adenoma mutational spectrum. Strikingly, we observe mutations in the TGF-β pathway and CEA-associated genes in 4 out of 11 adenomas, overlapping with the Wnt pathway. Immunohistochemical labeling reveals a nearly 5-fold increase in CEA levels in 23% of adenoma samples with a concomitant loss of TGF-β signaling. We also define a functional role by which the CEA B3 domain interacts with TGFBR1, potentially inactivating the tumor suppressor function of TGF-β signaling. Our study uncovers diverse mutational processes underlying the transition from early adenoma to cancer. This has broad implications for biomarker-driven targeting of CEA/TGF-β in high-risk adenomas and may lead to early detection of aggressive adenoma to CRC progression.

  4. Plasma TIMP-1 and CEA as markers for detection of primary colorectal cancer

    DEFF Research Database (Denmark)

    Christensen, Ib Jarle; Brünner, Nils; Dowell, Barry

    2015-01-01

    BACKGROUND/AIM: The combination of plasma tissue inhibitor of metalloproteinases-1 (1) and CEA has been shown to have utility in early detection of colorectal cancer (2). A prospective study was performed to validate previous findings. PATIENTS AND METHODS: Individuals undergoing large bowel endo...

  5. The US and the EU in CEA: Relations With Regional Powers

    NARCIS (Netherlands)

    Amineh, M.P.; Houweling, H.

    2003-01-01

    The US and the EU are important external actors in the post-Soviet CEA region. One challenge confronting US policymakers is balancing commercial interests in the region with security interests and foreign policy goals. These include a desire to contain Iran, partly because of its support for radical

  6. Monitoring different stages of breast cancer using tumour markers CA 15-3, CEA and TPA

    DEFF Research Database (Denmark)

    Sölétormos, G; Nielsen, D; Schiøler, V

    2004-01-01

    The ability of the tumour markers Cancer Antigen 15-3 (CA 15-3), Carcinoembryonic Antigen (CEA), and Tissue Polypeptide Antigen (TPA) to signal progression in breast cancer patients was investigated in this study. Marker interpretation considered the analytical variation, intra-individual biologi...

  7. PZ Fiber Loss Measurements at LLNL and Plan to Confirm Results at CEA/Thomson

    CERN Document Server

    Bass, I L

    2000-01-01

    The objective of this paper is to confirm the slow-axis loss of less than 0.1 dB/m for the PZ fiber manufactured for LLNL by 3M and to provide samples of the fiber to CEA/Thomson that will permit them to readily verify this result.

  8. Metastatic prostate cancer with elevated serum levels of CEA and CA19-9

    Directory of Open Access Journals (Sweden)

    Guang-Dar Juang

    2014-03-01

    Full Text Available Prostate-specific antigen (PSA is well known as a specific tumor marker for prostate cancer, but carcinoembryonic antigen (CEA- and carbohydrate antigen 19-9 (CA19-9-elevating adenocarcinomas originating in the prostate gland are rare. We report a case of metastatic adenocarcinoma of the prostate gland with a high serum level of CEA and CA19-9 in a 78-year-old man in whom prostate cancer (T3N1M1 had been diagnosed 2 years ago and who was treated with androgen deprivation therapy. He visited the emergency department because of a loss of appetite and abdominal pain. The serum CEA and CA19-9 levels were increased to 218.9 ng/mL (normal, <5 ng/mL and 212 ng/mL (normal, <27 ng/mL, respectively. The serum PSA level was slightly elevated (4.41 ng/mL. Computed tomography demonstrated multiple liver metastases, para-aortic lymph node enlargement, and lung metastases. A liver biopsy was performed and the specimen showed high-grade adenocarcinoma with focal positive staining for PSA. Despite chemotherapy with docetaxel, the patient died 3 months after treatment. Based on this case and a review of the literature, an aggressive variant of prostatic carcinoma with a high serum level of CEA and CA19-9 and a low PSA level was shown to progress rapidly with a poor prognosis.

  9. Woodianthus, género nuevo de Malváceas de Bolivia

    Directory of Open Access Journals (Sweden)

    Antonio Krapovickas

    2017-06-01

    Full Text Available Se describen Woodianthus, nuevo género y W. Sotoi, nueva especie de Santa Cruz, Bolivia. Se incluye una clave para mostrar la posición del nuevo género entre las tribus de las Malváceas

  10. 15 CFR 950.7 - Center for Environmental Assessment Services (CEAS).

    Science.gov (United States)

    2010-01-01

    ... REGULATIONS OF THE ENVIRONMENTAL DATA SERVICE ENVIRONMENTAL DATA AND INFORMATION § 950.7 Center for Environmental Assessment Services (CEAS). EDIS assists National decisionmakers in solving problems by providing... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Center for Environmental Assessment...

  11. Meeting of Directors and Heads of Department from CEA-Saclay, France

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Left to right: Ph. Pradelles, M. Jacquemet and T. Taylor in discussion during the December visit of Directors and Heads of Department from the Saclay centre of the French atomic energy commission (CEA) to CERN's LHC magnet test facility. Looking on is Yves Lemoigne.

  12. Clinical significance of combined testing of YKL-40 with CEA in Chinese colorectal cancer patients.

    Science.gov (United States)

    Ye, Hui-Ming; Lu, Yi-Zhuo; Liang, Xian-Ming; Lin, Yong-Zhi; Li, Yi; Zhang, Zhong-Ying; Tzeng, Chi-Meng

    2014-01-01

    To investigate the practical value of individual and combined testing of plasma levels of YKL-40, CEA, and CA199 for auxiliary diagnosis and detection of recurrence of colorectal cancer. ELISA and ECLIA were used to evaluate levels of YKL-40, CEA, and CA199 in 120 colorectal cancer patients (56 initial-diagnosis, 42 post-operative, and 22 recurrent cases). Forty-three patients with benign colorectal disease and 36 healthy patients were enrolled as controls. The relationship between YKL-40 and clinical indicators of tumor pathology was analyzed. The positive rate and diagnostic efficacy of single and combined YKL-40, CEA, and CA199 testing were assessed in patients with colorectal cancer. Plasma YKL-40 in the cancer group was significantly higher than in the benign control and healthy control group, and the mean values were 145.4 ng/mL, 107.7 ng/mL, and 51.3 ng/mL (p testing was combined with CEA or CA199, the positive rate increased to 82.1% and 80.3%, respectively. Through ROC curve analysis of the post-operative recurrent group against the non-recurrent group, the areas under the curve for YKL-40, CEA, and CA199 were found to be 0.907, 0.714, and 0.759, respectively. Based on the Dukes classification, the mean YKL-40 value for stages A/B, C, and D were 120.1 ng/mL, 131.7 ng/mL, and 226.8 ng/mL (p = 0.008), respectively. The plasma YKL-40 level gradually increased as the disease progressed. Lower degrees of tumor differentiation were correlated with higher YKL-40 levels. The mean YKL-40 values of high, medium, and low tumor differentiation groups were 96.8 ng/mL, 127.5 ng/mL, and 225.7 ng/mL (p = 0.004), respectively. The benefits of using YKL-40 testing are higher than CEA and CA199 for the monitoring of colorectal cancer recurrence. Combined testing of both YKL-40 and CEA was found to be optimal for auxiliary diagnosis of colorectal cancer. Plasma YKL-40 was found to be suitable for auxiliary diagnosis of colorectal cancer.

  13. Dispersion of Radionuclides and Exposure Assessment in Urban Environments: A Joint CEA and LLNL Report

    Energy Technology Data Exchange (ETDEWEB)

    Glascoe, Lee [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gowardhan, Akshay [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Lennox, Kristin [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Simpson, Matthew [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Yu, Kristen [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Armand, Patrick [Alternative Energies and Atomic Energy Commission (CEA), Paris (France); Duchenne, Christophe [Alternative Energies and Atomic Energy Commission (CEA), Paris (France); Mariotte, Frederic [Alternative Energies and Atomic Energy Commission (CEA), Paris (France); Pectorin, Xavier [Alternative Energies and Atomic Energy Commission (CEA), Paris (France)

    2014-12-19

    In the interest of promoting the international exchange of technical expertise, the US Department of Energy’s Office of Emergency Operations (NA-40) and the French Commissariat à l'Energie Atomique et aux énergies alternatives (CEA) requested that the National Atmospheric Release Advisory Center (NARAC) of Lawrence Livermore National Laboratory (LLNL) in Livermore, California host a joint table top exercise with experts in emergency management and atmospheric transport modeling. In this table top exercise, LLNL and CEA compared each other’s flow and dispersion models. The goal of the comparison is to facilitate the exchange of knowledge, capabilities, and practices, and to demonstrate the utility of modeling dispersal at different levels of computational fidelity. Two modeling approaches were examined, a regional scale modeling approach, appropriate for simple terrain and/or very large releases, and an urban scale modeling approach, appropriate for small releases in a city environment. This report is a summary of LLNL and CEA modeling efforts from this exercise. Two different types of LLNL and CEA models were employed in the analysis: urban-scale models (Aeolus CFD at LLNL/NARAC and Parallel- Micro-SWIFT-SPRAY, PMSS, at CEA) for analysis of a 5,000 Ci radiological release and Lagrangian Particle Dispersion Models (LODI at LLNL/NARAC and PSPRAY at CEA) for analysis of a much larger (500,000 Ci) regional radiological release. Two densely-populated urban locations were chosen: Chicago with its high-rise skyline and gridded street network and Paris with its more consistent, lower building height and complex unaligned street network. Each location was considered under early summer daytime and nighttime conditions. Different levels of fidelity were chosen for each scale: (1) lower fidelity mass-consistent diagnostic, intermediate fidelity Navier-Stokes RANS models, and higher fidelity Navier-Stokes LES for urban-scale analysis, and (2) lower-fidelity single

  14. Innovative CEA Information Server: Helping K--12 Teachers and Students Navigate the EUVE Mission Archive

    Science.gov (United States)

    Kronberg, F.; Hawkins, I.; Levandovsky, N.; Wong, L.; Arellano, V.; Ford, P.; Nguyen, K.; Malina, R. F.

    1995-12-01

    Internet access to the Extreme Ultraviolet Explorer (EUVE) mission archive for participants in the Science Online and Science Information Infrastructure programs will be facilitated by an innovative, World Wide Web--based data server being developed at the UC Berkeley Center for EUV Astrophysics (CEA). The Innovative CEA Information Server, being developed for the Science Education Program, will allow the user to easily select and access material from the EUVE mission archive. The entire archive, as part of an overarching CEA project, the EUVE Knowledge Base, will be logically structured into knowledge units. Each knowledge unit is defined as ``all of the information available at CEA about a given subject encapsulated into a self-contained, single, multimedia object.'' The user will be able to specify parameters that indicate the desired levels of complexity, breadth or scope, and format (e.g., text or graphics) of the requested knowledge units. The K--12 education materials for this Server are being developed at CEA via a ``Partners in Science'' teacher internship program funded by Research Corporation. Dr. Nelli Levandovsky, a physics teacher from San Francisco Unified School District's Galileo high school, created the following two tutorial plans this past summer: ``Be an Engineer---Learn How to Operate a Satellite'' and ``Be a Scientist---Learn How to Become a Space Researcher.'' Current development efforts are concentrated in two areas: (1) reviewing types of EUVE archival data and mission information and how these knowledge units can be packaged and presented; and (2) investigating how issues of breadth (e.g., scope or extent) and depth (e.g., complexity) of the knowledge units can be better presented in the construction of the Server. This work is supported by NASA contract NAS5-29298.

  15. Producing energy without greenhouse effect gases: the CEA action; Produire de l'energie sans gaz a effet de serre: l'action du CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    Major actor in the domain of new energy technologies, the CEA manages the french research on the hydrogen and the fuel cells. It is also implied with INES (National Institute for the Solar Energy) in the photovoltaic and thermal solar. With the IFP (French Petroleum Institute), it manages research on biofuels. Of course the thermonuclear fusion, for the development of the energy of the future, is in its research program too. This information document presents the possibilities of these energies and the associated research programs. (A.L.B.)

  16. Progress of the BT-EdF-CEA project. The lithium polymer battery; Avancees du projet BT-EdF-CEA. Batterie lithium polymere

    Energy Technology Data Exchange (ETDEWEB)

    Marginedes, D.; Majastre, H. [Bollore Technologies, 29 - Quimper (France); Baudry, P.; Lascaud, S. [Electricite de France, 77 - Moret sur Loing (France). Direction des Etudes et Recherches; Bloch, D.; Lebrun, N. [CEA Grenoble, CEREM, 38 (France)

    1996-12-31

    The lithium-polymer energy storage technology requires the production of thin films of huge surface. The BT-EdF-CEA consortium has studied the various manufacturing techniques of these films and their assembly. The process was chosen according to its productivity, low expensiveness, ecological impact and energy performances with capacities reaching 40 Ah. This paper explains: the objectives and specifications of the project, the advantage of the consortium and the role of the different partners, the results (coating, dry extrusion and battery element manufacturing techniques), and the electrochemical performances of the elements. (J.S.)

  17. The evaluation of the nuclear facilities safety at the CEA from 1999 to 2001; Le bilan de la surete des installations nucleaires du CEA du 1999 a 2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-11-01

    The aim of this document is the presentation of an evaluation of the problems and the safety methods in the concerned period. The first chapter presents the nuclear safety in the CEA. The second chapter is devoted to the organization and the quality for the safety: liabilities, audits, relations with the safety authorities and with the public. The chapters three and four deal respectively with the methodological and technical abilities supporting the exploitation teams and with the nuclear safety projects. The last chapter presents the experiments and events from 1999 to 2001. (A.L.B.)

  18. Hookah smoking and cancer: carcinoembryonic antigen (CEA levels in exclusive/ever hookah smokers

    Directory of Open Access Journals (Sweden)

    Chaouachi Kamal

    2008-05-01

    Full Text Available Abstract Background We have recently published some work on CEA levels in hookah (also called narghile, shisha elsewhere and cigarette smokers. Hookah smokers had higher levels of CEA than non-smokers although mean levels were low compared to cigarette smokers. However some of them were also users of other tobacco products (cigarettes, bidis, etc.. Objectives To find serum CEA levels in ever/exclusive hookah smokers, i.e. those who smoked only hookah (no cigarettes, bidis, etc., prepared between 1 and 4 times a day with a quantity of up to 120 g of a tobacco-molasses mixture each (i.e. the tobacco weight equivalent of up to 60 cigarettes of 1 g each and consumed in 1 to 8 sessions. Methods Enhanced chemiluminescent immunometric technique was applied to measure CEA levels in serum samples from 59 exclusive male smokers with age ranging from 20–80 years (mean = 58.8 ± 14.7 years and 8–65 years of smoking (mean = 37.7 ± 16.8. 36 non-smokers served as controls. Subjects were divided into 3 groups according to the number of preparations; the number of sessions and the total daily smoking time: Light (1; 1; ≤ 20 minutes; Medium (1–3; 1–3; >20 min to ≤ 2 hrs and Heavy smokers (2–4; 3–8; >2 hrs to ≤ 6 hrs. Because of the nature of distribution of CEA levels among our individuals, Wilcoxon's rank sum two-sample test was applied to compare the variables. Results The overall CEA levels in exclusive hookah smokers (mean: 3.58 ± 2.61 ng/ml; n = 59 were not significantly different (p ≤ 0.0937 from the levels in non-smokers (2.35 ± 0.71 ng/ml. Mean levels in light, medium and heavy smokers were: 1.06 ± 0.492 ng/ml (n = 5; 2.52 ± 1.15 ng/ml (n = 28 and 5.11 ± 3.08 ng/ml (n = 26 respectively. The levels in medium smokers and non-smokers were also not significantly different (p ≤ 0.9138. In heavy smokers, the CEA levels were significantly higher than in non-smokers (p ≤ 0.0001567. Conclusion Overall CEA levels in exclusive hookah

  19. Expression and significance of TSGF, CEA and AFP in patients before and after radical surgery for colon cancer.

    Science.gov (United States)

    Hu, Yi; Wang, Jing-Liang; Tao, Hai-Tao; Wu, Bai-Shou; Sun, Jin; Cheng, Yao; Dong, Wei-Wei; Li, Rui-Xin

    2013-01-01

    To explore the expression and significance of tumor specific growth factor (TSGF), carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP) in cancer tissue and serum of patients with colon cancer. Radical surgery for colon cancer was performed on 43 patients with laparoscope under conditions of general anesthesia. The Elisa method was used to detect the levels of serum TSGF, CEA and AFP before and after radical operation, and cancer tissue underwent TSGF, CEA and AFP immunohistochemistry staining after laparoscopic surgery. The decreased conditions of serum TSGF, CEA and AFP in patients with colon cancer at different levels of differentiation and clinical stagings were analyzed, and the relationships of expression rates between histological types, colon cancer morphology, lymph node metastasis and TSGF, CEA as well as AFP in cancer tissue were assessed. Compared with before radical surgery, the levels of serum TSGF, CEA and AFP decreased notably in patients after operations (pAFP was noted in patients with moderately differentiated cancer tissue (pAFP was the largest in patients at phase Dukes A (pAFP with different histological types and colon cancer morphologies (p>0.05). The positive expression rates of TSGF and CEA in patients with lymph node metastasis were significantly higher than those without lymph node metastasis (pAFP can be used to evaluate the effect of radical operation for colon cancer, and the changed levels of different markers are associated with tumor differentiation, clinical stating and presence or absence of lymph node metastasis.

  20. Improving tumor targeting and therapeutic potential of Salmonella VNP20009 by displaying cell surface CEA-specific antibodies.

    Science.gov (United States)

    Bereta, Michal; Hayhurst, Andrew; Gajda, Mariusz; Chorobik, Paulina; Targosz, Marta; Marcinkiewicz, Janusz; Kaufman, Howard L

    2007-05-22

    Genetically modified Salmonella typhimurium VNP20009 (VNP) is a useful vehicle for cancer therapy and vaccine development but exhibits limited tumor targeting in vivo. We engineered a novel VNP derivative that expressed carcinoembryonic antigen (CEA)-specific single chain antibody fragments (scFv) on the cell surface to increase tumor-specific targeting. There was significant scFv cell surface display visualized by flow cytometry and confocal microscopy when cells were probed with fluorescently labeled CEA. Atomic force microscopy (AFM) measurements on whole bacteria confirmed binding of unlabeled CEA to the displayed scFv. The modified VNP strain exhibited increased localization in the upper gastrointestinal tract of CEA transgenic mice and accumulated in CEA-expressing tumors. Furthermore, treatment with a single dose of the VNP derivative inhibited growth of MC38CEA tumors and was associated with local accumulation of CD3(+) T cells and CD11b(+) macrophages. The display of antibody fragments on the surface of VNP represents a novel strategy for both targeting CEA-expressing tumors and increasing the immunogenicity of Salmonella-based vaccines for cancer.

  1. Feasibility Study to Advanced Design Features of the APR1000 through CEA Ejection Accident Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yo Han; Yang, Chang Keun; Lee, Hwan Soo; Ha, Sang Jun [KEPCO Research Institute, Daejeon (Korea, Republic of)

    2011-05-15

    To supply various power level options to customers abroad, Korea Electric Power Corp. (KEPCO) has preliminarily designed the Advanced Power Reactor 1000 (APR1000) plants since the end of 2009. The APR1000 has been designed to consider the operational experience of Optimized Power Reactor 1000 (OPR1000) plants and some Advanced Design Features (ADFs) to meet the requirements of Generation III+ nuclear power plants. In this study, the Control Element Assembly (CEA) ejection accident was analyzed to confirm the feasibility of the ADFs. On the viewpoint of CEA ejection, the 24-month fuel cycle, 30% mixed oxide (MOX) fuel loading, or cold head design was reviewed among the ADFs. The results were compared each others

  2. Plasma TIMP-1 and CEA in detection of primary colorectal cancer

    DEFF Research Database (Denmark)

    Nielsen, Hans J; Brünner, Nils; Jorgensen, Lars N

    2011-01-01

    and independent detectors of CRC. Combining both biomarkers, independent contributions from each (TIMP-1, odds ratio (OR) = 1.8 (95% confidence interval (CI): 1.4-2.2), p = 5 ng/ml, OR = 2.3, 95% CI: 1.9-2.7 (p ...Objective. The combination of plasma tissue inhibitor of metalloproteinases-1 (TIMP-1) and carcinoembryonic antigen (CEA) may be valuable biomarkers for early detection of colorectal cancer (CRC). A prospective, population based study was performed to validate this hypothesis. Material and methods....... Plasma was obtained before endoscopy and TIMP-1 and CEA levels were determined after the inclusion of all individuals. Results. Findings were based on sigmoidoscopy in 1766 and colonoscopy in 2743 individuals. Colon cancer (CC) was detected in 184 and rectal cancer in 110 individuals. Ten individuals...

  3. C.-E.A. Winslow Day: proceedings of the June 3, 1977 centenary celebration.

    Science.gov (United States)

    Viseltear, A J

    1977-01-01

    Sponsored by Yale University, the City of New Haven, and the John B. Pierce Foundation, the C.-E.A. Winslow Day program consisted of speeches by Mr. Leonard Woodcock, President Emeritus, U.A.W., the Honorable Kenneth Gibson, Mayor of Newark, and Dr. Hector Acuña, Director, Pan American Health Organization; reminiscences of Ira Hiscock, Anna M.R. Lauder Professor Emeritus of Public Health, Mary Elizabeth Tennant, Associate Professor Emeritus of Nursing (Public Health), A. Pharo Gagge, Emeritus Fellow, John B. Pierce Foundation, and Mrs. Harriet Welch, Former President of the VNA of New Haven. The proceedings also included the presentation of gifts and the official C.-E.A. Winslow Day Proclamation.

  4. Fusion technology. Annual report of the Association CEA/EURATOM 1997

    Energy Technology Data Exchange (ETDEWEB)

    Magaud, P.; Le Vagueres, F

    1998-12-31

    The research and development work performed by the French EURATOM-CEA Association for fusion technology is part of the Fusion Programme of the European Community. This report compiles the work carried out during the year 1997 as follows: The ITER CEA activities and related developments are described in the first section (plasma facing components, vacuum vessel and shield, magnets, remote handling, safety); The second part is dedicated to the Long Term activities as Blankets and material developments, long term safety, socio-economic problem; The Underlying Technology activities are compiled in the third part of this report (plasma facing components, vacuum vessel and shield, magnets, remote handling, safety); And the fourth part describes the inertial confinement studies. (K.A.)

  5. Novedades en Convolvuláceas argentinas Novelties in Argentinean Convolvulaceae

    OpenAIRE

    Antonio Krapovickas

    2010-01-01

    Se describen cuatro especies nuevas de Convolvuláceas de Argentina: Ipomoea Vivianae,
    Jacquemontia cataractae y J. estrellensis
    Three new species of Convolvulaceae from Argentina are described: Ipomoea Vivianae, Jacquemontia cataractae and J. estrellensis.

  6. Methods of radiological monitoring of workers used by the medical units of CEA group

    Energy Technology Data Exchange (ETDEWEB)

    Sarbach, J. (CEA, 75 - Paris (France))

    1983-01-01

    The radioprotection of workers of the CEA group (France) is dealt with in each nuclear establishment by the service of three units. These are: the Service de Protection contre les Radiations (SPR), the Service Medical du Travail (SMT) and the Laboratoire d'Analyse et de Biologie Medicale (LABM). The activities of the SMT and the LABM are defined in function of the workpost of which the characteristics appear on the Workpost and Nuisances Sheet.

  7. EURATOM-CEA association contributions to the 21st symposium on fusion technology

    Energy Technology Data Exchange (ETDEWEB)

    Garin, P.; Grosman, A.; Beaumont, B. [and others

    2000-11-01

    The 27 contributions of EURATOM-Cea association have been gathered with 6 additional papers and 1 invited paper in this document. Most papers concern Tore-Supra and deal with the ergodic divertor, particle injection, impedance concept for ICRF antennas, low hybrid current drive, RF systems, the 118 GHz ECRH experiment, the inner first wall, improved vacuum vessel protection, pellet injection, material activation, and the CIEL project. 3 of the additional papers concern the model coil of ITER.

  8. Pyrochemical separation at CEA: Current results and future R and D program

    Energy Technology Data Exchange (ETDEWEB)

    Lacquement, J.; Bourg, S.; Boussier, H.; Conocar, O.; Hamel, C.; Laplace, A.; Maillard, C; Donnet, L.; Duhamet, J

    2004-07-01

    R and D studies are conducted at CEA/DEN to assess the potentialities of the pyrochemical processes which could be an advantageous alternative to hydrometallurgy for the reprocessing of: (i) targets as well as dedicated fuels for M.A transmutation if multiple recycling is considered, (ii) Generation IV gas cooled reactors. This paper gives an overview of the major experiments performed either in molten fluorides or chlorides. (authors)

  9. Elevated plasma gastrin, CEA, and CA 19-9 levels decrease after colorectal cancer resection.

    Science.gov (United States)

    Bombski, G; Gasiorowska, A; Orszulak-Michalak, D; Neneman, B; Kotynia, J; Strzelczyk, J; Janiak, A; Malecka-Panas, E

    2003-03-01

    Gastrin stimulates mucosal growth of much of the gastrointestinal tract and has also been implicated in promoting growth of colonic tumors, but its role in colorectal carcinogenesis remains controversial. This study determined fasting serum gastrin levels before and after surgery for colorectal cancer (CRC) and the relationship to the clinical stage of the disease to investigate it possible prognostic role. Fasting radioimmunoassay gastrin, CA 19-9, and CEA levels were measured before and after surgery for CRC. Helicobacter pylori status was also assessed since it causes significant hypergastrinemia. Mean fasting plasma gastrin level was significantly higher in CRC patients than in controls before surgery but not 59 days after surgery. Mean CEA and CA 19-9 levels were significantly higher in patients with CRC before surgery than after tumor resection. There was a significant positive correlation between the plasma gastrin, CEA, and CA 19-9 levels and the CRC stage (Dukes' classification). The significance of gastrin as a marker for diagnosis or prognostic purposes in colorectal cancer needs to be further examined.

  10. Detailed design studies at CEA for JT-60SA TF coils

    Energy Technology Data Exchange (ETDEWEB)

    Decool, P., E-mail: patrick.decool@cea.fr [CEA, IRFM F-13108 St-Paul-Lez-Durance Cedex (France); Marechal, J.L.; Portafaix, C.; Lacroix, B.; Gros, G.; Verger, J.M. [CEA, IRFM F-13108 St-Paul-Lez-Durance Cedex (France)

    2011-10-15

    Following a first conceptual design activity in which the general design of the JT-60SA TF system was defined and frozen in agreement with all the participants in the project (CEA, ENEA, F4E), a second phase had to be launched to deal with the detailed design. In this paper, we present the work performed at CEA on the TF coil design during this second phase. Part of this work, concerns the determination of conductor hydraulic performances during operation as well as in factory. The thermohydraulic of the conductor was also assessed to confirm the need of helium inlets and a specific design was developed and qualified to be compatible with the available hydraulic performance of the cryoplant. The mechanical behavior is still to be assessed and qualified. Last but not least, the inner electrical joints of the coil have been modified with respect to the original twin-box design developed by CEA for the ITER coils in order to simplify the fabrication process. A dedicated qualification program for their manufacture is ongoing.

  11. Reference Intervals for Alpha-Fetoprotein (AFP) and Carcinoembryonic Antigen (CEA) in Guangxi Zhuang Ethnic Males from the FAMHES Project.

    Science.gov (United States)

    Lao, Xianjun; Yang, Dongmei; Mo, Zengnan; Gao, Yong; Deng, Yan; Qin, Xue; Li, Shan

    2016-01-01

    Several studies have reported the reference intervals of serum AFP and CEA levels in ethnically diverse populations, but there is a lack of such reference data among Zhuang ethnic males. The aim of this study was to establish the locally validated reference intervals for AFP and CEA in the male population of the Guangxi Zhuang ethnic group. A total of 283 Zhuang ethnic males, aged 22 to 69 years, were included from the Fangchenggang Area Male Health and Examination Survey (FAMHES) project database. The one-sided upper 95th-percentile limit was used to estimate the reference intervals for serum AFP and CEA. The total non-parametric reference intervals for Zhuang ethnic males were AFP and CEA, respectively. Correlation analysis in this study showed AFP and CEA levels were significantly associated with increasing age, whereas no BMI related differences were found after adjustment for age. The present reference intervals for serum AFP and CEA values deviated from that reported in previous studies. Age-specific reference intervals should be performed in clinical laboratories to obtain more precise estimations for the clinical conditions of young adults and elderly people.

  12. Development and characterisation of MCT detectors for space astrophysics at CEA

    Science.gov (United States)

    Boulade, O.; Baier, N.; Castelein, P.; Cervera, C.; Chorier, P.; Destefanis, G.; Fièque, B.; Gravrand, O.; Guellec, F.; Moreau, V.; Mulet, P.; Pinsard, F.; Zanatta, J.-P.

    2017-11-01

    The Laboratoire Electronique et Traitement de l'Information (LETI) of the Commissariat à l'Energie Atomique (CEA, Grenoble, France) has been involved in the development of infrared detectors based on HgCdTe (MCT) material for over 30 years, mainly for defence and security programs [1]. Once the building blocks are developed at LETI (MCT material process, diode technology, hybridization, …), the industrialization is performed at SOFRADIR (also in Grenoble, France) which also has its own R&D program [2]. In past years, LETI also developed infrared detectors for space astrophysics in the mid infrared range - the long wave detector of the ISOCAM camera onboard ISO - as well as in the far infrared range - the bolometer arrays of the Herschel/PACS photometer unit -, both instruments which were under the responsibility of the Astrophysics department of CEA (IRFU/SAp, Saclay, France). Nowadays, the infrared detectors used in space and ground based astronomical instruments all come from vendors in the US. For programmatic reasons - increase the number of available vendors, decrease the cost, mitigate possible export regulations, …- as well as political ones - spend european money in Europe -, the European Space Agency (ESA) defined two roadmaps (one in the NIR-SWIR range, one in the MWIR-LWIR range) that will eventually allow for the procurement of infrared detectors for space astrophysics within Europe. The French Space Agency (CNES) also started the same sort of roadmaps, as part of its contribution to the different space missions which involve delivery of instruments by French laboratories. It is important to note that some of the developments foreseen in these roadmaps also apply to Earth Observations. One of the main goal of the ESA and CNES roadmaps is to reduce the level of dark current in MCT devices at all wavelengths. The objective is to use the detectors at the highest temperature where the noise induced by the dark current stays compatible with the photon

  13. Lithium/polymer batteries. Safety approach of the BT-EDF-CEA project; Accumulateurs lithium/polymere. Demarche securite du projet BT-EDF-CEA

    Energy Technology Data Exchange (ETDEWEB)

    Lascaud, S.; Baudry, P. [Electricite de France, 77 - Moret sur Loing (France). Direction des Etudes et Recherches; Majastre, H. [Bollore Technologies, 29 - Quimper (France); Bloch, D. [CEAGrenoble, CEREM, 38 (France)

    1996-12-31

    The BT-EdF-CEA consortium for the development and the performance improvement of lithium/polymer batteries has carried out a safety analysis of the industrial risk and the risk for users linked with this new technology. The process chosen for the manufacturing of lithium/polymer batteries does not generate any particular risk of personnel or environmental contamination. Security tests have permitted to observe and analyze the behaviour of 4 Ah elements during thermal shocks, perforation and crushing, and during external short-circuit on 20 Ah elements. These tests demonstrate the great thermal stability and the excellent behaviour of batteries in the case of partial destruction. (J.S.) 2 refs.

  14. Joint modelling of longitudinal CEA tumour marker progression and survival data on breast cancer

    Science.gov (United States)

    Borges, Ana; Sousa, Inês; Castro, Luis

    2017-06-01

    This work proposes the use of Biostatistics methods to study breast cancer in patients of Braga's Hospital Senology Unit, located in Portugal. The primary motivation is to contribute to the understanding of the progression of breast cancer, within the Portuguese population, using a more complex statistical model assumptions than the traditional analysis that take into account a possible existence of a serial correlation structure within a same subject observations. We aim to infer which risk factors aect the survival of Braga's Hospital patients, diagnosed with breast tumour. Whilst analysing risk factors that aect a tumour markers used on the surveillance of disease progression the Carcinoembryonic antigen (CEA). As survival and longitudinal processes may be associated, it is important to model these two processes together. Hence, a joint modelling of these two processes to infer on the association of these was conducted. A data set of 540 patients, along with 50 variables, was collected from medical records of the Hospital. A joint model approach was used to analyse these data. Two dierent joint models were applied to the same data set, with dierent parameterizations which give dierent interpretations to model parameters. These were used by convenience as the ones implemented in R software. Results from the two models were compared. Results from joint models, showed that the longitudinal CEA values were signicantly associated with the survival probability of these patients. A comparison between parameter estimates obtained in this analysis and previous independent survival[4] and longitudinal analysis[5][6], lead us to conclude that independent analysis brings up bias parameter estimates. Hence, an assumption of association between the two processes in a joint model of breast cancer data is necessary. Results indicate that the longitudinal progression of CEA is signicantly associated with the probability of survival of these patients. Hence, an assumption of

  15. CEA studies and qualifications prior to the JT-60SA TF coils manufacture

    Energy Technology Data Exchange (ETDEWEB)

    Decool, P., E-mail: patrick.decool@cea.fr; Cloez, H.; Gros, G.; Jiolat, G.; Maréchal, J.L.; Torre, A.; Verger, J.M.

    2013-10-15

    Following the first conceptual design activity in which the general design of the JT-60SA TF system was defined in agreement with all the participants in the project (CEA, ENEA, F4E), a second phase dealing with the detailed design was engaged by each of the voluntary contributors. For the French part which includes the procurement of 9 of the TF winding packs and their integration in the casing, an industrial contract was signed mid 2011 with Alstom (France). Several actions have been carried out to prepare the manufacturing phase. To precisely define one of the main interfaces which is the temporary electrical connection of the coils to the current leads during cold test in the CEA facility as well as their final connection to the feeders at the Naka site, a design compatible with both requirements was developed by CEA, supported by the previous developments led on the joints and assembly techniques. In addition to prepare the coils manufacture, hydraulic qualification was led on the first conductor qualification length to set the parameters which will be used by the coils manufacturer for conductor acceptance. At last, mechanical characterizations of both the conductor and of the empty compacted jacket were performed in order to define as precisely as possible the elastic and plastic properties of these components. These are crucial properties used during the bending process which is one of the most important operations during the winding pack manufacture. These data will be very helpful for the winding machine parameters settings as well as for designing the local bending tooling needed to shape the conductors extremities at the connection area and at the double pancakes joggles.

  16. Ocular rosacea: a review Rosácea ocular: revisão

    Directory of Open Access Journals (Sweden)

    Ana Carolina Cabreira Vieira

    2012-10-01

    Full Text Available Rosacea is a prevalent chronic cutaneous disorder with variable presentation and severity. Although considered a skin disease, rosacea may evolve the eyes in 58-72% of the patients, causing eyelid and ocular surface inflammation. About one third of the patients develop potentially sight-threatening corneal involvement. Untreated rosacea may cause varying degrees of ocular morbidity. The importance of early diagnosis and adequate treatment cannot be overemphasized. There is not yet a diagnostic test for rosacea. The diagnosis of ocular rosacea relies on observation of clinical features, which can be challenging in up to 90% of patients in whom accompanying roseatic skin changes may be subtle or inexistent. In this review, we describe the pathophysiologic mechanisms proposed in the literature, clinical features, diagnosis and management of ocular rosacea, as well as discuss the need for a diagnostic test for the disease.A rosácea é uma condição cutânea crônica, que possui apresentações clínicas variáveis. Apesar de considerada uma doença dermatológica, os olhos podem ser acometidos em 58-72% dos casos, causando inflamação palpebral e da superfície ocular. Aproximadamente um terço dos pacientes desenvolve acometimento corneano, podendo causar baixa visual significativa. Diagnóstico precoce e tratamento adequado são de extrema importância, devido à significativa morbidade ocular que a doença pode causar. Não há, até o momento, um teste diagnóstico para rosácea. O diagnóstico da rosácea ocular depende da observação das manifestações clínicas, o que pode ser bastante desafiador em até 90% dos pacientes, em que os achados cutâneos são discretos ou inexistentes. Nesta revisão, descrevemos os mecanismos fisiopatológicos propostos na literatura, manifestações clínicas, diagnóstico e tratamento da rosácea ocular, assim como abordamos a necessidade de um teste diagnóstico.

  17. Detección de alcaloides en semillas de plantas herbáceas nativas

    OpenAIRE

    Rios, Juan Manuel

    2015-01-01

    Se realizaron comparaciones entre ensayos cualitativos de rutina para establecer cuál resulta más sensible para detectar la presencia de alcaloides en muestras pequeñas de semillas de plantas herbáceas nativas. Se comparó entre los análisis de detección convencionales de precipitación y de cromatografía en capa delgada (CCD) utilizando reactivo de Dragendorff y reactivo de Iodoplatinato. A su vez se estimó un umbral mínimo de sensibilidad para la detección de alcaloides con reactivo de Dragen...

  18. Development of recycled plastic composites for structural applications from CEA plastics

    Science.gov (United States)

    Bhalla, Agrim

    Plastic waste from consumer electronic appliances (CEAs) such as computer and printer parts including Polystyrene (PS), Acrylonitrile Butadiene Styrene (ABS), Polystyrene (PS) and PC/ABS were collected using handheld FTIR Spectrophotometer. The blends of these plastics with High Density Polyethylene (HDPE) are manufactured under special processing conditions in a single screw compounding injection molding machine. The blends are thermoplastics have high stiffness and strength, which may enhance the mechanical properties of HDPE like tensile modulus, ultimate tensile strength, tensile break and tensile yield. These composites have a potential to be used for the future application of recycled plastic lumber, thus replacing the traditional wood lumber.

  19. Rosácea, demodex folliculorum y metronidazol tópico

    OpenAIRE

    Castellanos Lorduy, Héctor; Pardo Castro, Gloria

    2011-01-01

    La rosácea fue descrita como entidad probablemente asociada al acné por Unna (I), y se observa más frecuentemente en mujeres de piel clara, aunque una entidad consideraba una variante de ella, el rinofima, como patrimonio casi exclusivo de hombres. Su etiología continua siendo desconocida, aunque existe un consenso entre los investigadores con relación a su probable origen multifactorial. Entre los factores mencionados más frecuentemente se encuentran la predisposición genética, el daño dérmi...

  20. Fungos associados a sementes e plantas ornamentais herbáceas no Distrito Federal

    OpenAIRE

    Barreto, Sarah da Silva

    2009-01-01

    Estudou-se a microflora fúngica de sementes de nove espécies de plantas ornamentais herbáceas (Dahlia pinnata, Petunia x hybrida, Phlox drummondii, Rudbeckia hirta, Salvia farinacea, Salvia splendens, Tagetes patula, Viola tricolor e Zinnia elegans). Foram analisadas 13 amostras de sementes, sendo 5 delas estavam com data de validade vencida (P. drummondii, R. hirta, T. patula lote nº1, T. patula lote nº 2 e Z. elegans). Além disso, realizou-se o levantamento de fungos em mudas e plantas em f...

  1. Morfogénesis in vitro de cactáceas.

    OpenAIRE

    Téllez Román, Janeth

    2012-01-01

    En esta investigación se estudiaron las condiciones de cultivo in vitro y las respuestas morfogénicas de tres especies de cactáceas: Echinopsis chamaecereus Friedrich & Glaetzle “aurea”, Gymnocalicium mihanovichii cv. Hibotan y Mammillaria plumosa Weber ornamentales de importancia económica y la última en peligro de extinción. Con la regeneración de brotes, se establecieron protocolos eficientes para la propagación masiva in vitro a partir de la vía organogénica directa e indirecta de E. cham...

  2. Changes in soluble CEA and TIMP-1 levels during adjuvant chemotherapy for stage III colon cancer

    DEFF Research Database (Denmark)

    Aldulaymi, Bahir; Christensen, Ib Jarle; Sölétormos, György

    2010-01-01

    Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been suggested to be a valuable marker in colorectal cancer (CRC), but the effects of chemotherapy on TIMP-1 levels are unknown. The present study evaluated the effect of chemotherapy on TIMP-1 levels in comparison with carcinoembryonic antige...... (CEA) levels in patients with stage III colon cancer.......Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been suggested to be a valuable marker in colorectal cancer (CRC), but the effects of chemotherapy on TIMP-1 levels are unknown. The present study evaluated the effect of chemotherapy on TIMP-1 levels in comparison with carcinoembryonic antigen...

  3. Coherent investigation of nuclear data at CEA DAM: Theoretical models, experiments and evaluated data

    Energy Technology Data Exchange (ETDEWEB)

    Bauge, E.; Belier, G.; Cartier, J.; Chatillon, A.; Daugas, J.M.; Delaroche, J.P.; Dossantos-Uzarralde, P.; Duarte, H.; Dubray, N.; Ducauze-Philippe, M.; Gaudefroy, L.; Gosselin, G.; Granier, T.; Hilaire, S.; Chau, Huu-Tai P.; Laborie, J.M.; Laurent, B.; Ledoux, X.; Le Luel, C.; Meot, V.; Morel, P.; Morillon, B.; Roig, O.; Romain, P.; Taieb, J.; Varignon, C. [CEA, DAM, DIF, Arpajon (France); Authier, N.; Casoli, P.; Richard, B. [CEA Valduc, Is-sur-Tille (France)

    2012-08-15

    The domain of evaluated nuclear data involves at the same time, a close interaction between the field of nuclear applications and that of nuclear physics, and a close interaction between experiments and theory. The final product, the evaluated data file, synthesises vast amounts of information stemming from all of the above fields. In CEA DAM, all these aspects of nuclear data are investigated in a consistent way, making full use of experimental facilities and high-performance computing as well as numerous national and international collaborations, for the measurement, calculation, evaluation, and validation of nuclear data. (orig.)

  4. Can preoperative CEA and CA19-9 serum concentrations suggest metastatic disease in colorectal cancer patients?

    Science.gov (United States)

    Stojkovic Lalosevic, Milica; Stankovic, Sanja; Stojkovic, Mirjana; Markovic, Velimir; Dimitrijevic, Ivan; Lalosevic, Jovan; Petrovic, Jelena; Brankovic, Marija; Pavlovic Markovic, Aleksandra; Krivokapic, Zoran

    2017-01-01

    This study was designed to investigate the efficiency of preoperative serum carcinoembryonic antigen (CEA) and carbohydrate cancer antigen (CA19-9) levels for diagnosing synchronous liver metastases and lymph node in colorectal carcinoma (CRC) patients. A total of 300 patients with histologically diagnosed CRC were included in this study between May 2014 and March 2015. The data were obtained prospectively from patient's medical records: medical history, demographics, tumor location, differentiation (grade), depth of the tumor (T), lymph node metastases (N), distant metastases (M), lymphatics, venous and perineural invasion, and disease stage. Tumor markers were measured with an electrochemiluminescent assay and the reference value was 5ng/ml for CEA and for Ca19-9, 37u/ml. There was A high statistically significant difference in the levels of serum CEA and CA19-9 between different disease stages of CRC (P<0.001). Regarding different T stages of CRC, We noticed a significant statistical difference in CEA (stage I 3.76±8.73; II 5.68±17.27, III 7.56±14.81, and IV 70.90±253.23) and CA 19-9 levels (stage I 9.65±11.03, II 9.83±11.09; III 19.58±36.91, and IV 228.9±985.38, respectively). The mean CEA and CA19-9 serum levels were significantly higher in patients with regional lymph nodes involvement (CEA 37.21±177.85 vs 4.79±9.90, CA19-9 119.51±687.71 VS 12.24±17.69, respectively, P<0.05) and in liver metastases (CEA 86.56±277.65 vs. 5.98±12.98, and CA19-9 273.27±1073.46 vs. 4.98±3142, respectively, with P<0.001) in comparison to patients without lymph node involvement and liver metastases. We noticed a cut-off value for lymph nodes involvement, for CEA and CA 19-9, 3.5 ng/mL and 7.5 U/mL, respectively. While, a cut-off value for the presence of synchronous liver metastases of these two markers was 3.5ng/mL AND 5.5 U/mL. Our study showed that tumor makers, CEA and CA19-9, can be used as diagnostic factors regarding the severity of CRC specifically to

  5. Intracellular Targeting of CEA Results in Th1-Type Antibody Responses Following Intradermal Genetic Vaccination by a Needle-Free Jet Injection Device

    Directory of Open Access Journals (Sweden)

    Susanne Johansson

    2007-01-01

    Full Text Available The route and method of immunization, as well as the cellular localization of the antigen, can influence the generation of an immune response. In general, intramuscular immunization results in Th1 responses, whereas intradermal delivery of DNA by gene gun immunization often results in more Th2 responses. Here we investigate how altering the cellular localization of the tumor antigen CEA (carcinoembryonic antigen affects the quality and amplitude of DNA vaccine-induced antibody responses in mice following intradermal delivery of DNA by a needle-free jet injection device (Biojector. CEA was expressed either in a membrane-bound form (wild-type CEA or in two truncated forms (CEA6 and CEA66 with cytoplasmic localization, where CEA66 was fused to a promiscuous T-helper epitope from tetanus toxin. Repeated intradermal immunization of BALB/c mice with DNA encoding wild-type CEA produced high antibody titers of a mixed IgG1/IgG2a ratio. In contrast, utilizing the DNA construct that resulted in intracellular targeting of CEA led to a reduced capacity to induce CEA-specific antibodies, but instead induced a Th1-biased immune response.

  6. Development of a DNBR evaluation method for the CEA ejection accident in SMART core

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Dae Hyun; Yoo, Y. J.; In, W. K.; Chang, M. H. [Korea Atomic Energy Research Institute, Taejon (Korea)

    1999-12-01

    A methodology applicable to the analysis of the CEA ejection accident in SMART is developed for the evaluation of the fraction of fuel failure caused by DNB. The transient behavior of the core thermal-hydraulic conditions is calculated by the subchannel analysis code MATRA. The minimum DNBR during the accident is calculated by KRB-1 CHF correlation considering the 1/8 symmetry of hot assembly. The variation of hot assembly power during the accident is simulated by the LTC(Limiting transient Curve) which is determined from the analysis of power distribution data resulting from the three-dimensional core dynamics calculations. The initial condition of the accident is determined by considering LOC(Limiting Conditions for Operation) of SMART core. Two different methodologies for the evaluation of DNB failure rate are established; a deterministic method based on the DNB envelope, and a probabilistic method based on the DNB probability of each fuel rod. The methodology developed in this study is applied to the analysis of CEA ejection accident in the preliminary design core of SMART. As the result, the fractions of DNB fuel failure by the deterministic method and the probabilistic method are calculated as 38.7% and 7.8%, respectively. 16 refs., 16 figs., 5 tabs. (Author)

  7. Overview of the CEA R and D support to generation IV nuclear energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Carre, Frank; Anzieu, Pascal; Billot, Philippe; Brossard, Philippe; Fiorini, Gian-Luigi

    2004-07-01

    As a result of an early technology road-map performed at the end of 2000, the CEA selected a sequenced development of advanced gas cooled high temperature nuclear systems as main focus for its R and D programme on future nuclear energy systems. The selection of this research objectives originates both from the significance of fast neutrons and high temperature for nuclear energy to meet the needs anticipated beyond 2020/2030, and from the significant common R and D pathway that supports both medium term industrial projects and more advanced versions of gas cooled reactors. The first step of the 'Gas Technology Path' aims to support the development of a modular HTR likely to meet international market needs around 2020. The second step is a Very High Temperature Reactor (> 950 deg. C) to efficiently produce, among others, hydrogen though thermo-chemical water splitting or to generate electricity with an efficiency above 50%. The third step of the Path is a Gas Fast Reactor that features a fast-spectrum helium-cooled reactor and closed fuel cycle, with a direct-cycle helium turbine for electricity production and full recycle of actinides. The paper succinctly presents the R and D program launched in 2001 by the CEA with industrial partners on the 'Gas Technology Path', which is destined to become the contribution of France to the development of the VHTR and the GFR within the next phase of the Generation IV Forum.

  8. Application of Joint Detection of AFP, CA19-9, CA125 and CEA in Identification and Diagnosis of Cholangiocarcinoma.

    Science.gov (United States)

    Li, Yong; Li, Da-Jiang; Chen, Jian; Liu, Wei; Li, Jian-Wei; Jiang, Peng; Zhao, Xin; Guo, Fei; Li, Xiao-Wu; Wang, Shu-Guang

    2015-01-01

    To explore the application of joint detection of serum AFP, CA19-9, CA125 and CEA in identification and diagnosis of cholangiocarcinoma (CC). The levels of serum AFP, CA19-9, CA125 and CEA of both 30 patients with CC and 30 patients with hepatocellular carcinoma (HCC) were assessed. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic effects of single and joint detection of those 4 kinds of tumor markers for CC. The levels of serum CA19-9, CA125 and CEA in CC patients were higher than that in HCC patients,whereas that of serum AFP was significantly lower s. The area under ROC curve of single detection of serum AFP, CA19-9, CA125 and CEA were 0.05, 0.86, 0.84 and 0.83, with the optimal cutoff values of 15.4 ng/ml, 125.1 U/ml, 95.7 U/ml and 25.9 ng/ml, correspondingly, and the percentage correct single diagnosis was AFP, CA19-9, CA125 and CEA was the highest, with an area under the ROC curve of 0.94 (95%CI 0.88~0.99). Single detection of serum CA19-9, CA125 and EA is not meaningful. The sensitivity, specificity, the rate of correct diagnosis and the area under ROC curve of joint detection of AFP, CA19-9, CA125 and CEA are highest, indicating that the joint detection of these 4 tumor markers is of great importance in the diagnosis of CC.

  9. Efficacy of 18F-FDG PET/CT in investigation of elevated CEA without known primary malignancy

    Directory of Open Access Journals (Sweden)

    Simon Sin-man Wong

    2016-01-01

    Full Text Available Aim: To evaluate the efficacy of 18flurodeoxyglucose positron emission tomography/computer tomography (18F-FDG PET/CT in investigating patients with elevated carcinoembryonic antigen (CEA and without known primary malignancy, and the impact of PET/CT findings on patient management. Setting and Design: PET/CT scans done in a tertiary hospital between December 2007 and February 2012 for elevated CEA in patients without known primary malignancy were retrospectively reviewed. Materials and Methods: The PET/CT findings, patients' clinical information, level of CEA, histological diagnosis, and subsequent management were retrieved by the electronic patient record for analysis. Statistical Analysis: Data were analyzed using SPSS version 19. Results: One hundred and one PET/CT scans were performed for patients with elevated CEA. Fifty-eight of these were performed for patients with known primary malignancy and were excluded; 43 PET/CT scans were performed for patients without known primary malignancy and were included. Thirty-three (77% had a positive PET/CT. Among the 32 patients with malignancy, 15 (47% suffered from lung cancer and 8 (25% suffered from colorectal cancer. The sensitivity (97%, specificity (82%, positive predictive value (94%, negative predictive value (90%, and accuracy (93% were calculated. Thirty (91% patients had resultant change in management. The mean CEA level for patients with malignancy (46.1 ng/ml was significantly higher than those without malignancy (3.82 ng/ml (P < 0.05. In predicting the presence of malignancy, a CEA cutoff at 7.55 ng/ml will achieve a sensitivity of 91% and a specificity of 73%. Conclusion: PET/CT, in our study population, appears to be sensitive, specific, and accurate in investigating patients with elevated CEA and without known primary malignancy. In addition to diagnosis of underlying primary malignancy, PET/CT also reveals occult metastases which would affect patient treatment options.Its role in

  10. Efficacy of 18F-FDG PET/CT in investigation of elevated CEA without known primary malignancy

    Science.gov (United States)

    Wong, Simon Sin-man; Yu, Wong L; Wang, Ki; Ahuja, Anil T

    2016-01-01

    Aim: To evaluate the efficacy of 18flurodeoxyglucose positron emission tomography/computer tomography (18F-FDG PET/CT) in investigating patients with elevated carcinoembryonic antigen (CEA) and without known primary malignancy, and the impact of PET/CT findings on patient management. Setting and Design: PET/CT scans done in a tertiary hospital between December 2007 and February 2012 for elevated CEA in patients without known primary malignancy were retrospectively reviewed. Materials and Methods: The PET/CT findings, patients' clinical information, level of CEA, histological diagnosis, and subsequent management were retrieved by the electronic patient record for analysis. Statistical Analysis: Data were analyzed using SPSS version 19. Results: One hundred and one PET/CT scans were performed for patients with elevated CEA. Fifty-eight of these were performed for patients with known primary malignancy and were excluded; 43 PET/CT scans were performed for patients without known primary malignancy and were included. Thirty-three (77%) had a positive PET/CT. Among the 32 patients with malignancy, 15 (47%) suffered from lung cancer and 8 (25%) suffered from colorectal cancer. The sensitivity (97%), specificity (82%), positive predictive value (94%), negative predictive value (90%), and accuracy (93%) were calculated. Thirty (91%) patients had resultant change in management. The mean CEA level for patients with malignancy (46.1 ng/ml) was significantly higher than those without malignancy (3.82 ng/ml) (P < 0.05). In predicting the presence of malignancy, a CEA cutoff at 7.55 ng/ml will achieve a sensitivity of 91% and a specificity of 73%. Conclusion: PET/CT, in our study population, appears to be sensitive, specific, and accurate in investigating patients with elevated CEA and without known primary malignancy. In addition to diagnosis of underlying primary malignancy, PET/CT also reveals occult metastases which would affect patient treatment options. Its role in

  11. Protein expression levels of carcinoembryonic antigen (CEA) in Danish ovarian cancer patients: from the Danish 'MALOVA'ovarian cancer study

    DEFF Research Database (Denmark)

    Hogdall, E.V.; Christensen, L.; Blaakaer, J.

    2008-01-01

    from 189 women diagnosed with low malignant potential ovarian tumours (LMP, borderline ovarian tumours) and 571 women diagnosed with ovarian cancer (OC). RESULTS: Using 30% as the cut-off level for CEA over-expression, 18% of LMPs and 4% of OCs were positive. A higher proportion of mucinous tumours...... (I to IV), the highest CEA expression compared with no expression was found to be a prognostic factor (level 3 versus negative: HR = 2.12, 95%CI 1.11-4.05). FIGO stage, residual tumour after primary surgery, age at diagnosis, other histological types versus serous adenocarcinoma and low versus high...

  12. Status of CEA studies on the fast spectrum option for supercritical water reactors

    Energy Technology Data Exchange (ETDEWEB)

    Marsault, Ph.; Thevenot, C.; Rimpault, G.; Antoni, O.; Arnoux, P.; Aniel, S. [CEA Cadarache, 13108 Saint-Paul-lez-Durance (France)

    2006-07-01

    Full text: The concepts of supercritical-pressure light water cooled reactors (SCWR) have been proposed and studied for almost 40 years. However, limited results are available on these concepts and in particular on the key technological points related to concept feasibility. CEA is conducting targeted R and D studies to be in a position to have a better judgment of the interest of these concepts. The paper reports on the work progress on the fast spectrum version of SCWR. The CEA R and D programme is focused on feasibility and conceptual design studies of a SCWR version with a fast neutron spectrum. The challenge is to determine a core design where high conversion ratio must also meet a negative void coefficient at end of cycle for a power range of about 1000 MWe and burnup near 60 GWd/t. First evaluations are performed with a pre-dimensioning tool (COPERNIC sheets) and followed by neutronic and thermal-hydraulic applications (ERANOS code system and CATHARE 2.5 code) Other parts of the programme are considered to be essential in order to be able to address the key points of SCWR feasibility: - extension to supercritical conditions of computer codes needed to make evaluations and limited conceptual design studies (reactor core physics, thermal-hydraulics). Neutronic studies have to take in account coupling effect with thermal-hydraulic relative to strong water density change along the fuel assembly: the CEA effort cover a generic reference calculation with coupling TRIPOLI and FLICA code (neutronic Monte-Carlo and thermalhydraulic) for the SCWR thermal spectrum option. Other main effort concern the adaptation of CATHARE 2.5 to fully describe depressurization from supercritical domain: adaptation of correlation, ability to perform computation in both supercritical and standard domain; - material studies, the cladding material being the major concern: tests are performed on selected material in despite of experimental difficulties dues to the high temperature range

  13. Estaquia caulinar herbácea e semilenhosa de Drimys brasiliensis1

    Directory of Open Access Journals (Sweden)

    Luciele Milani Zem

    Full Text Available Drimys brasiliensis conhecida como cataia, é uma espécie arbórea nativa da Mata Atlântica. Tem importância fitoquímica, fitoterapêutica, aromática e econômica, utilizada na fabricação de licores, condimentos, dentre outros. É considerada uma espécie de difícil multiplicação via sementes, apresentando dormência por imaturidade embrionária. Assim, objetivou-se estudar a propagação vegetativa por meio da indução do enraizamento de estacas herbáceas e semilenhosas submetidas a diferentes concentrações de ácido indolbutírico (IBA, coletadas em duas épocas do ano (junho/2011 e dezembro/2011. Foram utilizados os tratamentos: testemunha (100% água, 0 (50% água e 50% álcool; 1.500; 3.000 e 6.000 mg L-1IBA (em solução hidroalcoólica 50% para o inverno e, no verão, os mesmos tratamentos, exceto 0 mg L-1IBA. Foi conduzido um experimento em delineamento inteiramente casualizado, em esquema fatorial de 5 concentrações x 2 tipos de estacas em junho/2011; e outro experimento com 4 concentrações x 2 épocas de coleta (estacas de junho/2011 e estacas de dezembro/2011 Após 120 dias em casa de vegetação, avaliou-se a porcentagem de estacas enraizadas, número de raízes/estaca, comprimento médio de raízes/estaca, porcentagem estacas vivas, com calos, mortas, com novas brotações e que mantiveram as folhas iniciais. A aplicação de IBA não influenciou nenhuma das variáveis estudadas. Estacas herbáceas apresentaram melhor enraizamento (46,75% quando comparadas às semilenhosas (34,44%. A coleta realizada em dezembro/2011 apresentou maior número de raízes/estaca (5,47 porém maior mortalidade (29,05% que em junho/2011 (4,25 e 12,19%, respectivamente. Sendo assim, para o enraizamento de cataia é indicada a utilização de estacas caulinares herbáceas, coletadas em épocas frias.

  14. A produção de anonáceas no Brasil

    Directory of Open Access Journals (Sweden)

    Eurico Eduardo Pinto de Lemos

    2014-01-01

    Full Text Available As anonáceas compõem um grupo de plantas que se têm destacado em várias partes do mundo, principalmente por produzirem frutos de grande interesse comercial. Entre os mais destacados membros desta família, estão a cherimólia (Annona cherimola, a pinha (A. squamosa, a atemoia (híbrido A. squamosa x A. cherimola, e a graviola (A. muricata. No Brasil, pelas suas características de clima tropical e com baixas altitudes na maior parte de seu território, a cherimólia tem sido pouco cultivada devido a sua exigência em temperaturas baixas. As demais apresentam áreas cultivadas em diversas regiões do País para fazer frente à demanda dos mercados de frutas frescas (pinha e atemoia e processadas (graviola. Todavia, o interesse neste grupo de plantas é mais abrangente, tendo em vista que inúmeras pesquisas comprovam que compostos secundários obtidos de várias anonáceas possuem atividade pesticida e antitumoral. Este trabalho objetiva apresentar um quadro atual da produção de anonáceas no Brasil, focando nas principais anonas cultivadas nas diferentes regiões do País. Para tanto, foram levantados dados de produção e principais tecnologias utilizadas nestas culturas. Os dados de produção obtidos serviram para estabelecer uma estimativa aproximada da realidade da produção de atemoia, pinha e graviola no Brasil. Os resultados demonstram um vigoroso crescimento na área total de cultivo, na produção e no uso de tecnologias modernas para as três espécies consideradas neste estudo. Apontam também para uma expansão dos cultivos em todas as regiões do Brasil, principalmente no Nordeste.

  15. Big Data solution for CTBT monitoring: CEA-IDC joint global cross correlation project

    Science.gov (United States)

    Bobrov, Dmitry; Bell, Randy; Brachet, Nicolas; Gaillard, Pierre; Kitov, Ivan; Rozhkov, Mikhail

    2014-05-01

    Waveform cross-correlation when applied to historical datasets of seismic records provides dramatic improvements in detection, location, and magnitude estimation of natural and manmade seismic events. With correlation techniques, the amplitude threshold of signal detection can be reduced globally by a factor of 2 to 3 relative to currently standard beamforming and STA/LTA detector. The gain in sensitivity corresponds to a body wave magnitude reduction by 0.3 to 0.4 units and doubles the number of events meeting high quality requirements (e.g. detected by three and more seismic stations of the International Monitoring System (IMS). This gain is crucial for seismic monitoring under the Comprehensive Nuclear-Test-Ban Treaty. The International Data Centre (IDC) dataset includes more than 450,000 seismic events, tens of millions of raw detections and continuous seismic data from the primary IMS stations since 2000. This high-quality dataset is a natural candidate for an extensive cross correlation study and the basis of further enhancements in monitoring capabilities. Without this historical dataset recorded by the permanent IMS Seismic Network any improvements would not be feasible. However, due to the mismatch between the volume of data and the performance of the standard Information Technology infrastructure, it becomes impossible to process all the data within tolerable elapsed time. To tackle this problem known as "BigData", the CEA/DASE is part of the French project "DataScale". One objective is to reanalyze 10 years of waveform data from the IMS network with the cross-correlation technique thanks to a dedicated High Performance Computer (HPC) infrastructure operated by the Centre de Calcul Recherche et Technologie (CCRT) at the CEA of Bruyères-le-Châtel. Within 2 years we are planning to enhance detection and phase association algorithms (also using machine learning and automatic classification) and process about 30 terabytes of data provided by the IDC to

  16. On 28 April, CERN welcomed Jean-Claude Petit, director of programmes of the Commissariat á l'Energie Atomique (CEA) in France, and Olivier Pagezy, finance director of the CEA.

    CERN Multimedia

    Maximilien Brice

    2005-01-01

    They visited the assembly hall for the CMS experiment, the COMPASS experiment and the test facilities for the LHC magnets. They are pictured (no 01) in the ATLAS cavern with Peter Jenni, ATLAS spokesman, and Gabriele Fioni, CEA deputy director of programmes

  17. TRIPOLI-4®, CEA, EDF and AREVA Reference Monte Carlo Code

    Science.gov (United States)

    2014-06-01

    This paper presents an overview of TRIPOLI-4®, the fourth generation of the 3D continuous-energy Monte Carlo code developed by the Service d'Etudes des Réacteurs et de Mathématiques Appliquées (SERMA) at CEA Saclay. The paper surveys the generic features: programming language, parallel operation, tracked particles, nuclear data, geometry, simulation modes, standard variance reduction techniques, sources, tracking and collision algorithms, tallies, sensitivity studies. Moreover, specific and recent features are also detailed: Doppler broadening of the elastic scattering kernel, neutron and photon material irradiation, advanced variance reduction techniques, Green's functions, cycle correlation correction, nuclear data management and depletion capabilities. The productivity tools (T4G, SALOME TRIPOLI, T4RootTools), the Verification & Validation process and the distribution and licensing policy are finally presented.

  18. Cea-DSM-DAPNIA-SACM contribution to IFMIF KEP phase June 2000 to December 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-05-01

    The international fusion materials irradiation facility (IFMIF) requires the generation by a linear accelerator (LINAC) of 250 mA continuous current of deuterons at a nominal energy of 40 MeV. The basic approach is to provide 2 linac modules, each delivering 125 mA to a common target. The accelerators begin with a deuteron ion source and a low-energy beam transport to a radio-frequency quadrupole (RFQ), a buncher and a pre-accelerator up to 5 MeV. The key element technology phase (KEP) was initiated in 2000 with the objective of reducing some key technology risk factors. The IFMIF KEP is carried out at the Cea and it focuses on 5 issues: the ECR source, the 4-vanes RFQ design, the radio-frequency system, the DTL (drift tube linac) design, and high power diagnostics. The present report reviews progress made in the 5 issues quoted above. (A.C.)

  19. GEDEON: A joint venture between research (CEA and CNRS) and industry (EDF and FRAMATOME)

    CERN Document Server

    Schapira, J P

    1999-01-01

    Nuclear waste partitioning and transmutation (P and T) are considered in France as an official line of research, in accordance with the Law of December 30, 1991 concerning research in the field of long lived and highly active nuclear waste. A research group called GEDEON (GEstion des DEchets par des Options Nouvelles) has been set up between CEA, CNRS, EDF and FRAMATOME with the aim to carry out basic research related to the use of accelerator driven subcritical systems (ADS) and of thorium as an option to reduce the waste long term impacts. In the partners agreement of GEDEON, the following subjects have been identified: spallation physics, nuclear data, subcritical neutronic studies, materials, thorium, system and scenario studies. The organization as well as the scientific program and activities of GEDEON are presented.

  20. CEAS/AIAA/ICASE/NASA Langley International Forum on Aeroelasticity and Structural Dynamics 1999. Pt. 2

    Science.gov (United States)

    Whitlow, Jr., Woodrow (Editor); Todd, Emily N. (Editor)

    1999-01-01

    The proceedings of a workshop sponsored by the Confederation of European Aerospace Societies (CEAS), the American Institute of Aeronautics and Astronautics (AIAA), the National Aeronautics and Space Administration (NASA), Washington, D.C., and the Institute for Computer Applications in Science and Engineering (ICASE), Hampton, Virginia, and held in Williamsburg, Virginia June 22-25, 1999 represent a collection of the latest advances in aeroelasticity and structural dynamics from the world community. Research in the areas of unsteady aerodynamics and aeroelasticity, structural modeling and optimization, active control and adaptive structures, landing dynamics, certification and qualification, and validation testing are highlighted in the collection of papers. The wide range of results will lead to advances in the prediction and control of the structural response of aircraft and spacecraft.

  1. Microflora de Bromeliáceas do estado de Pernambuco, Brasil

    Directory of Open Access Journals (Sweden)

    Luis Tavares de Lyra

    1976-01-01

    Full Text Available O autor estudou a microflora de dois gêneros de BROMELIACEAE: Hoenbergia e Portea. As coletas do material foram feitas em seis regiões do Estado de Pernambuco; 1 Região da Mata-Úmida; 2 Região da Mata-Seca; 3 Região do Agreste Central; 4 Região do Agreste Setentrional; 5 Região do Agreste Meridional; 6 Região do Recife. As seguintes diatomáceas indicadoras de águas poluídas (espécies oligossaprobias foram encontradas nas seis regiões estudadas: Gomphonema parvulum (Kutz Grunow., Hantzschia amphioxys Grunow, Pinnularia borealis Ehr., Pinnularia microstauron (Ehr Cleve, gomphonema gracile Ehr., Nitzschia palea Kutz., Melosira roeseana Rabenh., Navicula mutica Kutz., Navicula cryptocephala Kutz., Eunotia pectinalis (Kutz Rabenh. Foram também observadas CHLOROPHYCEAS nas estações chuvosa e seca nas diversas regiões. Algumas são indicadoras de oligossaprobidade: Scenedesmus quadricauda (Turpin brebisson. Chlorococcum sp., Chlorella sp. Os fatores ecológicos e comentários referentes ás diatomáceas foram anotados no texto. A tabela I indica a frequência das diatomáceas nas seis regiões estudadas. Maior número dessas diatomáceas, registramos nas regiões do Agreste. A tabela II mostra a temperatura e pH da água de Hoenbergia e Portea em ambas as estações do ano (inverno e verão. Observamos a ocorrência de larvas de culex em Portea e hoenbergia, entretanto, raramente encontramos larvas de Anopheles. As coletas foram feitas durante as estações chuvosa e seca em Hoenbergia e Portea. Determinamos 35 espécies provenientes de 78 amostras coletadas durante o período de 26 meses.The author studied the microflora from two genera of Bromeliaceae: Hoenbergia and Portea. The material was collected in six natural regions of Pernambuco State: 1 Humid Forest Region; 2 Dry forest region; 3 Central Agreste Region; 4 Setentrional Agreste Region; 5 Meridional Agreste Region; 6 Recife Region. The following diatoms that indicate polluted

  2. Colecta y establecimiento de anonáceas en El Salvador

    Directory of Open Access Journals (Sweden)

    Eduardo Cruz

    2000-01-01

    Full Text Available El Centro Nacional de Tecnología Agropecuaria y Forestal (CENTA, a través de la Unidad de Recursos Fitogenéticos, inició en 1998 un diagnóstico geográfico de especies de anonáceas, con el objetivo de explorar, recolectar, caracterizar y establecer colecciones de campo en las Estaciones Experimentales. Las características evaluadas para frutos fueron: peso, largo y diámetro, número de semillas, textura de cáscara y pulpa; forma de fruto y cárpelos, daño por plagas y enfermedades y un análisis bromatológico. Como resultado de este trabajo se estableció la colección de anonáceas con las siguientes especies: squamosa, cherimola, reticulata, muricata, purpurea, diversifolia, holosericea y glabra. En la caracterización morfológica preliminar Annona muricata obtuvo un promedio de 175 semillas/fruto y 1,319 g en peso del fruto. A. cherimola con pulpa muy arenosa y carpelos no prominentes. A. squamosa con pulpa dulce, blanca y cárpelos muy prominentes. De la caracterización bromatológica se determinó que Annona muricata dio contenidos de humedad superiores a 82,8%; fibra cruda de 1,84% y fósforo con 367 ppm. En Annona diversifolia con menor grasa 0,01%. La mayor incidencia por plagas en frutos y semillas fue causado por el perforador Bephrateloides sp. La antracnosis (Colletotrichum sp. en frutos y follaje fue la enfermedad más observada

  3. A dye-sensitized solar cell acting as the electrical reading box of an immunosensor: Application to CEA determination.

    Science.gov (United States)

    Truta, Liliana A A N A; Moreira, Felismina T C; Sales, M Goreti F

    2018-02-07

    Monitoring cancer biomarkers in biological fluids has become a key tool for disease diagnosis, which should be of easy access anywhere in the world. The possibility of reducing basic requirements in the field of electrochemical biosensing may open doors in this direction. This work proposes for this purpose an innovative electrochemical immunosensing system using a photovoltaic cell as an electrical reading box. Immunosensing ensures accuracy, the electrochemical-ground of the device ensures sensitivity and detectability, and the photovoltaic cell drives the system towards electrical autonomy. As proof-of-concept, Carcinoembryonic antigen (CEA) was used herein, a cancer biomarker of clinical relevance. In brief, a conductive glass with a fluorine doped tin oxide film was used as conductive support and modified with anti-CEA by means of a bottom-up approach. All stages involved in the biochemical modification of the FTO surface were followed by electrochemical techniques, namely electrochemical impedance spectroscopy and cyclic voltammetry. This electrode acted as counter electrode of a dye-sensitized solar cells, and the electrical output of this cell was monitored for the different concentrations of CEA. Under optimized conditions, the device displayed a linear behaviour against CEA concentration, from 5 pg/mL to 15 ng/mL. The immunosensor was applied to the analysis of CEA in urine from healthy individual and spiked with the antigen. Overall, the presented approach demonstrates that photovoltaic cells may be employed as an electrical reading box of electrochemical biosensors, yielding a new direction towards autonomous electrochemical biosensing. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

  4. A combination of preoperative CT findings and postoperative serum CEA levels improves recurrence prediction for stage I lung adenocarcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Yamazaki, Motohiko, E-mail: xackey2001@gmail.com [Department of Radiology, Niigata University Graduate School of Medical and Dental Sciences (Japan); Ishikawa, Hiroyuki [Department of Radiology, Niigata University Graduate School of Medical and Dental Sciences (Japan); Kunii, Ryosuke [Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences (Japan); Tasaki, Akiko; Sato, Suguru; Ikeda, Yohei; Yoshimura, Norihiko [Department of Radiology, Niigata University Graduate School of Medical and Dental Sciences (Japan); Hashimoto, Takehisa; Tsuchida, Masanori [Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences (Japan); Aoyama, Hidefumi [Department of Radiology, Niigata University Graduate School of Medical and Dental Sciences (Japan)

    2015-01-15

    Objectives: To assess the prognostic value of combined evaluation of preoperative CT findings and pre/postoperative serum carcinoembryonic antigen (CEA) levels for pathological stage I lung adenocarcinoma. Methods: This retrospective study included 250 consecutive patients who underwent complete resection for ≤3-cm pathological stage I (T1–2aN0M0) adenocarcinomas (132 men, 118 women; mean age, 67.8 years). Radiologists evaluated following CT findings: maximum tumor diameter, percentage of solid component (%solid), air bronchogram, spiculation, adjacency of bullae or interstitial pneumonia (IP) around the tumor, notch, and pleural indent. These CT findings, pre/postoperative CEA levels, age, gender, and Brinkman index were assessed by Cox proportional hazards model to determine the best prognostic model. Prognostic accuracy was examined using the area under the receiver operating characteristic curve (AUC). Results: Median follow-up period was 73.2 months. In multivariate analysis, high %solid, adjacency of bullae or IP around the tumor, and high postoperative CEA levels comprised the best combination for predicting recurrence (P < 0.05). A combination of these three findings had a greater accuracy in predicting 5-year disease-free survival than did %solid alone (AUC = 0.853 versus 0.792; P = 0.023), with a sensitivity of 85.7% and a specificity of 74.3% at the optimal threshold. The best cut-off values of %solid and postoperative CEA levels for predicting high-risk patients were ≥48% and ≥3.7 ng/mL, respectively. Conclusion: Compared to %solid alone, combined evaluation of %solid, adjacency of bullae or IP change around the tumor, and postoperative CEA levels improves recurrence prediction for stage I lung adenocarcinoma.

  5. Efficient tumor regression by adoptively transferred CEA-specific CAR-T cells associated with symptoms of mild cytokine release syndrome.

    Science.gov (United States)

    Wang, Linan; Ma, Ning; Okamoto, Sachiko; Amaishi, Yasunori; Sato, Eiichi; Seo, Naohiro; Mineno, Junichi; Takesako, Kazutoh; Kato, Takuma; Shiku, Hiroshi

    2016-01-01

    Carcinoembryonic antigen (CEA) is a cell surface antigen highly expressed in various cancer cell types and in healthy tissues. It has the potential to be a target for chimeric antigen receptor (CAR)-modified T-cell therapy; however, the safety of this approach in terms of on-target/off-tumor effects needs to be determined. To address this issue in a clinically relevant model, we used a mouse model in which the T cells expressing CEA-specific CAR were transferred into tumor-bearing CEA-transgenic (Tg) mice that physiologically expressed CEA as a self-antigen. The adoptive transfer in conjunction with lymphodepleting and myeloablative preconditioning mediated significant tumor regression but caused weight loss in CEA-Tg, but not in wild-type mice. The weight loss was not associated with overt inflammation in the CEA-expressing gastrointestinal tract but was associated with malnutrition, reflected in elevated systemic levels of cytokines linked to anorexia, which could be controlled by the administration of an anti-IL-6 receptor monoclonal antibody without compromising efficacy. The apparent relationship between lymphodepleting and myeloablative preconditioning, efficacy, and off-tumor toxicity of CAR-T cells would necessitate the development of CEA-specific CAR-T cells with improved signaling domains that require less stringent preconditioning for their efficacy. Taken together, these results suggest that CEA-specific CAR-based adoptive T-cell therapy may be effective for patients with CEA + solid tumors. Distinguishing the fine line between therapeutic efficacy and off-tumor toxicity would involve further modifications of CAR-T cells and preconditioning regimens.

  6. 2004 annual report. Defense, safety, energy, information, health. CEA in the center of big European challenges; Rapport annuel 2004. Defense, securite, energie, information, sante. Le CEA au coeur des grands defis europeens

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    This document is the 2004 annual report of the French atomic energy commission (CEA). It presents the R and D activities of the CEA in three main domains: 1 - defense and safety, maintaining perenniality of nuclear dissuasion and nuclear safety: supplying nuclear weapons to armies, maintaining dissuasion capability with the simulation program, sharing R and D means with the scientific community and the industrial world, designing and maintaining naval nuclear propulsion reactors, cleansing Marcoule and Pierrelatte facilities, monitoring treaties and fighting against proliferation and terrorism; 2 - energy, developing more competitive and cleaner energy sources: nuclear waste management, optimization of industrial nuclear activities, future nuclear systems and new energy technologies, basic research on energy, radiobiology and toxicology; 3 - information and health, valorizing industry thanks to technological research and supplying new tools for health and medical research: micro- and nano-technologies, software technologies, basic research for industrial innovation, nuclear technologies for health and bio-technologies. (J.S.)

  7. Evaluation 2000 and regulation and method. Release monitoring and environmental surveillance around Cea centers; Bilan 2000 et reglementation et methode. Controle des rejets et surveillance de l'environnement des centres CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-06-01

    This publication counts for the year 2000 for the evaluation of liquid and gaseous radioactive effluents releases and the radioactivity levels measured in the vicinity of Cea centers, through the air, water, vegetation and milk surveillance. An analysis of the results from 1996 to 2000 allows to follow their evolution. A second booklet develops the sampling and measurement methods made on effluents in environment. It present besides the regulation applied to effluents monitoring. (N.C.)

  8. Training and Certification Program for Certified Energy Auditors (CEA) and Certified Building Commissioning Professionals (CBCP)

    Energy Technology Data Exchange (ETDEWEB)

    Kent, Bill

    2012-08-24

    The Association of Energy Engineers (AEE) has offered energy efficiency training and certification programs for over 30 years. During that time AEE has certified more than 22,000 professionals. All of our certification programs are the result of extensive industry research and program development and oversight by certification boards. For this project award, AEE proposed to work with the Department of Energy to utilize and extend existing industry recognized Certified Energy Auditor (CEA) and Certified Building Commissioning Professional (CBCP) programs under this Training Program Development Announcement. These expanded training programs will have significant impact in training professionals for building commissioning and energy auditing to achieve the goal of bringing existing buildings up to their optimal energy performance potential and ensuring that new buildings maintain their expected optimal level of performance. The goals and objectives of the training development project were achieved with the development of new training programs that are now being offered as self-sustaining commercial training and certification programs. These new programs are training and certifying professionals who are accomplishing the goal of increasing building energy performance in both existing and new buildings.

  9. CEA and AREVA HTR fuel particles manufacturing and characterization R and D Program

    Energy Technology Data Exchange (ETDEWEB)

    Charollais, F.; Perez, M.; Fonquernie, S.; Ablitzer, C.; Duhart, A.; Perrais, C.; Dugne, O.; Guillermier, P.; Harbonnier, G

    2004-07-01

    Worldwide, renewal of interest for High Temperature Reactors (HTR) moderated by graphite, using helium gas as coolant is due to the possibility offered by HTR technology to build small competitive modular units (100-300 MWe) and to produce high temperature gas required for hydrogen production or heat production. In this context, Commissariat a l'Energie Atomique (CEA) supported by AREVA, conducts R and D projects on HTR, which one is the mastering of the UO{sub 2} TRISO fuel fabrication technology including innovating prospects. The first step of the work is to recover fabrication know-how and to improve fabrication processes (for preparing the erection of a fuel pilot manufacture line of HTR particles). The second step will be the manufacturing of HTR fuel elements in purpose of irradiation tests. This publication deals with the know-how recovery and improved processes of UO{sub 2} TRISO manufacture, i.e. kernel and coatings manufacturing, the development of innovative characterization methods, a modelling approach of CVD processes and the status of the future laboratory manufacture line. Alternative fuel designs are also investigated, for instance the way of manufacturing UCO and UC{sub x} kernels with higher refractory coating material such as ZrC. (authors)

  10. EURATOM-CEA association contributions to the 18. IAEA fusion energy conference

    Energy Technology Data Exchange (ETDEWEB)

    Ghendrih, Ph.; Peysson, Y.; Hoang, G.T. [and others

    2000-12-01

    The 9 contributions of EURATOM-Cea association to the fusion energy conference hold at Sorrento are gathered in this document with 7 additional papers. The different titles are: 1) Ergodic divertor experiments on the route to steady state operation of Tore-Supra, 2) High power lower hybrid current drive experiments in Tore-Supra tokamak, 3) Electron transport and improved confinement on Tore-Supra, 4) ECRH experiments and developments for long pulse in Tore-Supra, 5) Impurity penetration and contamination in Tore-Supra ergodic divertor experiments, 6) Real time plasma feed-back control: an overview of Tore-Supra achievements, 7) Numerical assessment of the ion turbulent thermal transport scaling laws, 8) Design of next step tokamak: consistent analysis of plasma flux consumption and poloidal, 9) Large superconducting conductors and joints for fusion magnets: from conceptual design to test at full size scale, 10) Burst-prone transport in tokamaks with internal transport barriers, 11) Electrostatic turbulence with finite parallel correlation length and radial electric field generation, 12) Theoretical issues in tokamak confinement: internal-edge transport barriers and runaway avalanche confinement, 13) Core and edge confinement studies with different heating methods in JET, 14) Confinement and transport studies of conventional scenarios in ASDEX upgrade, 15) First test results for the ITER central solenoid model coil, and 16) Progress of the ITER central solenoid model coil program.

  11. Test Results of the Third LHC Main Quadrupole Magnet Prototype at CEA/Saclay

    CERN Document Server

    Derégel, J; Gourdin, C; Hervieu, M; Ogitsu, T; Peyrot, M; Rifflet, J M; Schild, T; Simon, F; Tortschanoff, Theodor; Tsuchiya, K

    2002-01-01

    The construction of the third second-generation main quadrupole magnet prototype for LHC has been completed at CEA/Saclay in November 2000. The magnet was tested at 1.9 K. Similarly to the two first ones, this prototype has exceeded the operating current in one training step and exhibited excellent training memory after a thermal cycle. This paper describes the quench performance and quench start localization determined by means of voltage-taps and a quench antenna system developed in collaboration with KEK. As this magnet was equipped with capacitive gauges, the stresses during cool-down and powering have been recorded and are in agreement with FE computations. The newly designed quench heaters have improved efficiency and reproducibility compared to those of the first generation. Magnetic measurements have been performed at various stages. The cold measurements show minor differences with those at room temperature and are similar to those of the two first magnets of this design. These results prove that the...

  12. Enxertia herbácea em Myrtaceae nativas do Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Daiane Silva Lattuada

    2010-12-01

    Full Text Available O objetivo deste trabalho foi testar a viabilidade da técnica de enxertia herbácea em frutíferas nativas da família Myrtaceae. O experimento foi realizado em casa de vegetação do Departamento de Horticultura e Silvicultura/ UFRGS, em Porto Alegre. Duas espécies de Myrtaceae nativas foram usadas, tanto como porta-enxerto quanto como enxerto, Eugenia uniflora (Pitangueira e E. involucrata (Cerejeira-do-rio-grande ou Cerejeira-do-mato, totalizando quatro combinações. O método de enxertia adotado foi por garfagem em fenda cheia, em ramos herbáceos, com diâmetro médio do porta-enxerto de 0,1cm, enquanto os ramos dos enxertos apresentavam diâmetro médio entre 0,08 a 0,1cm, para as duas espécies. As análises foram quinzenais e, após 70 dias, foram analisadas estatisticamente a pega e a altura média das brotações emitidas. O delineamento experimental foi o completamente casualizado, com quatro repetições, sendo cada unidade experimental composta de cinco enxertos. Os resultados indicaram pega de 60% na combinação Pitangueira-Pitangueira (porta enxerto - enxerto. As demais combinações mostraram-se ineficientes.

  13. ICL-Based OF-CEAS: A Sensitive Tool for Analytical Chemistry.

    Science.gov (United States)

    Manfred, Katherine M; Hunter, Katharine M; Ciaffoni, Luca; Ritchie, Grant A D

    2017-01-03

    Optical-feedback cavity-enhanced absorption spectroscopy (OF-CEAS) using mid-infrared interband cascade lasers (ICLs) is a sensitive technique for trace gas sensing. The setup of a V-shaped optical cavity operating with a 3.29 μm cw ICL is detailed, and a quantitative characterization of the injection efficiency, locking stability, mode matching, and detection sensitivity is presented. The experimental data are supported by a model to show how optical feedback affects the laser frequency as it is scanned across several longitudinal modes of the optical cavity. The model predicts that feedback enhancement effects under strongly absorbing conditions can cause underestimations in the measured absorption, and these predictions are verified experimentally. The technique is then used in application to the detection of nitrous oxide as an exemplar of the utility of this technique for analytical gas phase spectroscopy. The analytical performance of the spectrometer, expressed as noise equivalent absorption coefficient, was estimated as 4.9 × 10-9 cm -1 Hz-1/2, which compares well with recently reported values.

  14. Light ion source for proton/deuteron production at CEA Saclay for the Spiral2 project

    Energy Technology Data Exchange (ETDEWEB)

    Tuske, O.; Adroit, G.; Delferriere, O.; Denis, J-F.; Gauthier, Y.; Girardot, P.; Gobin, R.; Harrault, F.; Guiho, P.; Sauce, Y.; Uriot, D.; Vacher, T.; Van Hille, C. [CEA/Saclay, DSM/IRFU/SACM, F- 91191-Gif/Yvette (France); Graehling, P.; Hosselet, J.; Maazouzi, C. [IPHC, Institut Pluridisciplinaire Hubert Curien, Strasbourg (France)

    2012-02-15

    The production of rare radioactive ion beam (RIB) far from the valley of stability is one of the final purposes of the Spiral2 facility in Caen. The RIB will be produced by impinging a deuteron beam onto a carbon sample to produce a high neutron flux, which will interact with a uranium target. The primary deuteron beam is produced by an ion source based on ECR plasma generation. The deuteron source and the low energy beam transport (LEBT) has been assembled and tested at CEA Saclay. Diagnostics from other laboratories were implemented on the LEBT in order to characterize the deuteron beam produced and compare it to the initial simulations. The ion source has been based on a SILHI-type source, which has demonstrated good performances in pulsed and continuous mode, and also a very good reliability on long term operation. The 5 mA of deuteron beam required at the RFQ entrance is extracted from the plasma source at the energy of 40 kV. After a brief description of the experimental set-up, this article reports on the first beam characterization experiments.

  15. Assessment of a European V–4Cr–4Ti alloy – CEA-J57

    Energy Technology Data Exchange (ETDEWEB)

    Le Flem, Marion, E-mail: marion.leflem@cea.fr [CEA, DEN, DMN, SRMA, F-91191, Gif Sur Yvette (France); Gentzbittel, Jean-Marie [CEA, DRT, LITEN, DTBH, LCTA, F-38054, Grenoble (France); Wident, Pierre [CEA, DEN, DMN, SRMA, F-91191, Gif Sur Yvette (France)

    2013-11-15

    About 30 kg of 7 mm-thick plates (grade CEA-J57) were fabricated to support development of vanadium alloys for applications as structural components in future fast neutron fission reactors. After a stress relieve annealing at 973 K, the material exhibited elongated grains and large Ti-rich precipitates oriented in the rolling direction. After final heat-treatment of 2 h at 1273 K, the microstructure was fully recrystallised with remaining aligned large precipitates. Charpy V-notch and tensile specimens were machined in various directions of stress-relieved and recrystallised plates. The fracture energy and the lateral expansion were determined between 113 K and 598 K. Stress-relieved specimens clearly highlighted an anisotropic behavior with both ductile and brittle features while the recrystallized specimens are all ductile: a DBTT of 113 K is suggested. The fracture mode and morphology were related to the microstructure and especially to the Ti-rich precipitate distribution. Additionally, tensile tests were performed at room temperature and between 873 K and 1223 K. The results were consistent with previous results: after a plateau around 400 MPa, a significant decrease in tensile strength is observed above 1023 K. The fracture surfaces always exhibited ductile fracture mode. The present work suggests the good quality of this vanadium alloy.

  16. METABOLISMO ÁCIDO DE LAS CRASULÁCEAS Crassulacean Acid Metabolism

    Directory of Open Access Journals (Sweden)

    THOMAS DAVID GEYDAN

    Full Text Available Se presenta una revisión del metabolismo ácido de las Crasuláceas, caracterizado por la ocurrencia, actividad y plasticidad del mecanismo desde un punto de vista fisiológico, bioquímico y molecular, enmarcado por la presencia de las denominadas cuatro fases de dicho metabolismo y su repercusión y expresión por diversas restricciones hídricas a nivel ecológico. Se presentan las principales enzimas y metabolitos básicos para el funcionamiento del metabolismo CAM, así como su modo de acción y control celular. Finalmente, se muestra que la plasticidad fenotípica en patrones de expresión CAM se encuentra mediada por condiciones ambientales y por señalizaciones moleculares.A review of Crassulacean acid metabolism is presented, characterized by showing the occurrence, activity and plasticity of these complex mechanism at the physiological, biochemical and molecular level, framed by the presence of the denominated four phases in CAM and its repercussion and expression due to different stresses in an ecological context. The basic enzymes, and metabolites necessary for the optional functioning of CAM are presented as well as their mode of action and cellular control. Finally, it is shown how environmental conditions and molecular signalling mediate the phenotypic plasticity.

  17. The 400W at 1.8K Test Facility at CEA-Grenoble

    Science.gov (United States)

    Roussel, P.; Girard, A.; Jager, B.; Rousset, B.; Bonnay, P.; Millet, F.; Gully, P.

    2006-04-01

    A new test facility with a cooling capacity respectively of 400W at 1.8K or 800W at 4.5K, is now under nominal operation in SBT (Low Temperature Department) at CEA Grenoble. It has been recently used for thermohydraulic studies of two phase superfluid helium in autumn 2004. In the near future, this test bench will allow: - to test industrial components at 1.8K (magnets, cavities of accelerators) - to continue the present studies on thermohydraulics of two phase superfluid helium - to develop and simulate new cooling loops for ITER Cryogenics, and other applications such as high Reynolds number flows This new facility consists of a cold box connected to a warm compressor station (one subatmospheric oil ring pump in series with two screw compressors). The cold box, designed by AIR LIQUIDE, comprises two centrifugal cold compressors, a cold turbine, a wet piston expander, counter flow heat exchangers and two phase separators at 4.5K and 1.8K. The new facility uses a Programmable Logic Controller (PLC) connected to a bus for the measurements. The design is modular and will allow the use of saturated fluid flow (two phase flow at 1.8K or 4.5K) or single phase fluid forced flow. Experimental results and cooling capacity in different operation modes are detailed.

  18. COLOFONIA DE PINÁCEAS CUBANAS PARA EL CONTROL DE ENFERMEDADES TROPICALES TRANSMITIDAS POR MOLUSCOS

    Directory of Open Access Journals (Sweden)

    Y. Arteaga-Crespo

    2010-01-01

    Full Text Available La esquistosomiasis, enfermedad tropical transmitida por molusco, ocupa el segundo lugar en enfermedades parasitarias después de la malaria. En Cuba no existe la esquistosomiasis aunque sí el riesgo a contraerla, puesto que en nuestra fauna se encuentran especies que pueden actuar como hospederos intermediarios del tremátodo causante de la enfermedad. El objetivo del trabajo fue evaluar el polvo de colofonia sobre larvas de Biomphalaria havanensis para el control de vectores que propagan la esquistosomiasis, según la metodología desarrollada por la Organización Mundial para la Salud (OMS y descrita por Mott para la evaluación de plantas con acción molusquicida. Los resultados del estudio sugieren la acción molusquicida de colofonia obtenida de pináceas cubanas (Pinus caribaea y Pinus tropicalis sobre larvas de Biomphalaria havanensis en dosis letales (DL50 y DL90 son 44, 33 mg·L-1 y 141, 76 mg·L-1, respectivamente. La ecuación de regresión correspondiente fue: Y = - 0, 412 + 1, 086 ln X con un valor del coeficiente de correlación R 0, 99 y error estándar 0, 13. Las dosis revelan la efectividad de los componentes presentes en la colofonia, resultados comparables con publicaciones de extractos de otras especies de plantas.

  19. Starting the production of the CEA JT-60SA TF coils at Alstom

    Energy Technology Data Exchange (ETDEWEB)

    Decool, P., E-mail: patrick.decool@cea.fr [CEA, IRFM, F-13108 St-Paul-Lez-Durance Cedex (France); Cloez, H.; Gros, G.; Jiolat, G.; Marechal, J.L.; Nicollet, S.; Torre, A.; Verger, J.M. [CEA, IRFM, F-13108 St-Paul-Lez-Durance Cedex (France); Nusbaum, M.; Billotte, G.; Crepel, B.; Bourquard, A.; Schweitzer, M. [Alstom Power Systems STTG Magnets, 90018 Belfort (France); Davis, S.; Phillips, G. [Fusion for Energy, Boltzmannstr 2, 85748 Garching (Germany)

    2015-10-15

    Highlights: • We describe the status of the JT-60SA TF coils manufacture at Alstom. • The manufacturing workflow and related tooling are described. • Completion of qualification activities has allowed to start the coils production. • Production of the first winding up to its impregnation is described. • Winding of following coils is started. - Abstract: Within the framework of the Broader Approach, the French voluntary contributor represented by CEA awarded a contract for the production of 9 toroidal field coils for the JT-60SA project to Alstom, Belfort, France in mid-2011. A first preparatory phase was led to establish the team, produce the manufacture drawings, define the manufacturing process, procure the required tooling and prepare the quality documentation. In parallel, a qualification phase on the critical major processes has proved Alstom's ability to master the processes and reach the requirements. After reviewing of the qualification results and modification of the processes and tooling to overcome the encountered difficulties, a Production Readiness Review has authorized Alstom to start the production winding. A prototype double pancake was wound as the first of series. In addition to complying with the pancake width all around the D shape, the straightness of the centreline in the critical straight leg part was correct. The production of the successive double pancakes to constitute the first winding pack was then completed and the joints and terminals were manufactured. The paper describes the completion of the last qualifications and the status of the winding production.

  20. Meeting of Directors and Heads of Department from CEA-Saclay, France

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Directors and Heads of Department from the Saclay centre of the French atomic energy commission (CEA) visited CERN in December. They are pictured here at the LHC magnet test facility in building SM18. On the left behind the visitors are the test benches where magnets are prepared for installation in String 2: the 120-metre full-scale model of an LHC cell of the regular part of the arc, which can be seen to the right. Photos 01, 02: Left to right: Marc Dejardin, Alain Givernaud, Louis Laurent, François Kircher, Antoine Masurel, Joël Feltesse, André Menez, T. Taylor, Philippe Pradelles, Bernard Sevestre, Michel Roche, Jean-Yves Gascoin, Thierry Lieven, Michel Spiro, Jean-Pierre Pervès, Yves Lemoigne, Béatrice Reder, Georges Carola, Philippe Lebrun, Yves Bourlat, Bertrand Mercier, Jean-Paul Langlois, Patrick Laurent, Didier Moulin, Xavier Vitart, Marc Serre, Jean-Louis Pierrey, Patrick Jarry, Bruno Mansoulié, Stéphane Lequien, Hervé Barbelin, Philippe Pallier, Jean-Yves Guillamot, and Norbert Sioegel.

  1. Chemoradiation-induced changes in serum CEA and plasma TIMP-1 in patients with locally advanced rectal cancer

    DEFF Research Database (Denmark)

    Aldulaymi, Bahir; Christensen, Ib J; Sölétormos, György

    2010-01-01

    BACKGROUND: Preoperative biomarkers serum CEA and plasma TIMP-1 have been shown to have prognostic and predictive value in patients with colorectal cancer. The aim of the present study was to evaluate the possible impact of chemoradiotherapy (CRT) on preoperative biomarker levels in patients with...... biomarker levels may be affected by treatments received before blood sample collection. Translation of results of preoperative biomarkers needs to take such facts into consideration....... with rectal cancer. PATIENTS AND METHODS: Thirty-three patients with rectal cancer were prospectively included. The patients received CRT for 6-8 weeks. Blood samples were collected before CRT (pre-CRT) and preoperatively (post-CRT). RESULTS: Median CEA was 3.5 (range 0.6-36.1) µg/l and 2.4 (range 0...

  2. Mide Kanserlerinde Preoperatif Serum CEA, CA19-9 ve AFP Düzeylerinin Klinikopatolojik Faktörlerle Korelasyonu

    OpenAIRE

    Dirican, Abuzer; Ünal, Bülent; Işık, Burak; Sümer, Fatih; Kayaalp, Cüneyt; Aslan, İlhan

    2008-01-01

    Amaç: Gastrik adenokarsinomlu hastalarda preoperatif serum karsinoemriyonik antijen (CEA), CA19-9 ve alfa-fetoprotein (AFP) düzeyi ile klinikopatolojik faktörlerin korelasyonunu araştırmak. Metot: Gastrik adenokarsinom sebebiyle Ankara Yıldırım Beyazıt Eğitim Hastanesi 2. Cerrahi Kliniğinde ameliyat edilen 74 hastanın kayıtları retrospektif olarak incelendi. Hastaların preoperatif serum CEA, CA19-9, AFP düzeyleri ile bazı klinikopatolojik faktörler (tümör evresi, karaciğer metastazı, perit...

  3. Differences in plasma gastrin, CEA, and CA 19-9 concentration in patients with proximal and distal colorectal cancer.

    Science.gov (United States)

    Bombski, Grzegorz; Gasiorowska, Anita; Orszulak-Michalak, Daria; Neneman, Beata; Kotynia, Justyna; Strzelczyk, Janusz; Janiak, Adam; Malecka-Panas, Ewa

    2002-01-01

    We investigated whether there are differences in plasma gastrin, as compared with carcinoembryonic antigen (CEA) and cancer antigen (CA) 19-9 between patients with proximal and distal colorectal cancer. Gastrin concentration has also been analyzed, dependent on the tumor stage, in order to evaluate the possible prognostic role of this measurement. In 50 patients with colon cancer-fasting gastrin, CA 19-9 and CEA levels were evaluated. Mean plasma-gastrin level in patients with distal tumor yielded 105.31 +/- 12.5 microU/L and was significantly higher than in patients with the proximal tumor site (42.2 +/- 3.1 microU/L) as well as in controls (p < 0.001). No significant difference was observed between mean plasma gastrin in patients with proximal tumors and the control group. The mean CEA plasma level was significantly higher (p < 0.01) in patients with distal tumors (9.1 +/- 1.1 ng/mL) than in those with proximal tumors (1.48 +/- 0.1 ng/mL). Similarly, the mean CA 19-9 plasma level was significantly higher (p < 0.01) in patients with distal tumor (19.9 +/- 2.1 U/mL) than in those with proximal tumor: 1.8 +/- 0.2 U/mL. The mean gastrin plasma, CA 19-9, and CEA level was significantly higher in group of Duke's stage C and D as compared to A and B. We speculate that observed differences in gastrin concentration in patients with distal and proximal tumors may contribute to the distinct pathogenesis and biological properties of those cancers. The significance of gastrin as a marker for diagnostic or prognostic purposes in colorectal cancer requires further study.

  4. [TSST-1 regulated synergistically by 5HRE and CEAp activates lymphocytes to kill CEA-positive tumor cells specifically].

    Science.gov (United States)

    Tian, Yong; Sun, Xue-jun; Wang, Wei; Wang, Wei

    2010-06-01

    To evaluate the inhibitory effect of lymphocytes activated by the superantigen of toxic shock syndrome toxin-1 (TSST-1), which is regulated synergistically by 5 copies of hypoxia-responsive element (5HRE) and promoter of carcino-embryonic antigen (CEAp), against the carcino-embryonic antigen (CEA)-positive human colon carcinoma cell line LoVo under hypoxia condition in vitro. The eukaryotic expressive vector was constructed with the transmembrane superantigen gene of 5HRE-CEAp-regulated TSST-1-linker-CD80TM, and was transfected into CEA-positive human colon carcinoma cell line LoVo and CEA-negative human cervical carcinoma cell line HeLa by Lipofectamine 2000. Stably transfected cell lines were selected by G418. RT-PCR was employed to examine the expression of TC mRNA. Peripheral blood lymphocytes(PBL) of healthy people were extracted and then activated by the lysates of tumor cells stably transfected with TC. Concurrently, PBL were cultured together with stably transfected tumor cells in order to kill these cells. Then the proliferative effect of TSST-1 on PBL, and the killing effect of PBL against the stably transfected tumor cells were detected by MTT. Monoclonal LoVo and HeLa cells stably transfected with TC were successfully obtained. Expression of TC mRNA in monoclonal LoVo cells under hypoxia condition was significantly higher than those under normoxia condition as confirmed by RT-PCR. Monoclonal HeLa cells did not express TC under either hypoxia condition or normoxia condition. As is shown by MTT assay, TSST-1 expressed by the monoclonal LoVo cells could effectively activate PBL to proliferate under hypoxia condition, resulting in dose-dependent inhibition on the proliferation of LoVo cells that expressed TSST (Pkill CEA-positive tumor cells specifically under hypoxia condition.

  5. Design of potent, non-toxic anticancer peptides based on the structure of the antimicrobial peptide, temporin-1CEa.

    Science.gov (United States)

    Yang, Qing-Zhu; Wang, Che; Lang, Lei; Zhou, Yang; Wang, He; Shang, De-Jing

    2013-11-01

    Recent advances in the search for novel anticancer agents have indicated that the positively charged antimicrobial peptides have emerged as promising agents offering several advantages over the conventional anticancer drugs. As a naturally occurring, cationic, α-helical antimicrobial peptide, temproin-1CEa has been proved to exhibit a potent anticancer effect and a moderate hemolytic activity. In order to reduce the hemolytic activity of temporin-1CEa and improve its anticancer potency towards a range of human breast cancer cells, in the present study, six analogs of temporin-1CEa were rationally designed and synthesized. The amphipathicity levels and α-helical structural patterns of peptides were reserved, while their cationic property and hydrophobicity were changed. The results of MTT and hemolysis assay indicated that the analog peptides displayed an improved anticancer activity and showed an overall optimized therapeutic index. The hydrophobicity of peptides was positively correlated with their hemolytic and antitumor activities. Moreover, the data suggest a strategy of increasing the cationicity while maintaining the moderate hydrophobicity of naturally occurring amphipathic α-helical peptides to generate analogs with improved cytotoxicity against tumor cells but decreased activity against non-neoplastic cells such as human erythrocytes. This work highlights the potential for rational design and synthesis of improved antimicrobial peptides that have the capability to be used therapeutically for treatment of cancers.

  6. Produção integrada de Anonáceas no Brasil

    Directory of Open Access Journals (Sweden)

    Raimundo Braga Sobrinho

    2014-01-01

    Full Text Available Os conceitos técnicos e operacionais contidos na Produção Integrada (PI vêm atender de forma direta às exigências dos órgãos nacionais e internacionais que fiscalizam o comércio de "commodities", dando ênfase à segurança e a qualidade dos alimentos produzidos e consumidos pela população. A garantia da produção de um alimento seguro e rastreável é alcançada mediante o esforço harmônico de todos os integrantes da cadeia produtiva. Esse sistema pressupõe o cumprimento das Normas Técnicas Específicas (NTE para cada produto, permitindo o controle efetivo do sistema produtivo agropecuário por meio do monitoramento de todas as etapas na cadeia produtiva. Esse conceito teve início com o Manejo Integrado de Pragas (MIP e, posteriormente, expandiu-se para uma visão holística, estruturada em quatro pilares de sustentação: organização da base produtiva; sustentabilidade do sistema; monitoramento dos processos; e formação de um banco de dados. Dentro desta visão, insere-se a Produção Integrada de Anonáceas, projeto iniciado em 2010, com apoio do CNPq/MAPA/EMBRAPA e instituições parceiras. As anonáceas representam um nome genérico para designar as plantas da família Annonaceae constituída por cerca de 120 gêneros e em torno de 2.300 espécies. No Brasil, estão registrados 29 gêneros, dentro dos quais cerca de 260 espécies. Entre as espécies de maior importância comercial, destacam-se a graviola (Annona muricata L., pinha (Annona squamosa L., cherimólia (Annona cherimólia, Mill. e a atemoia, hibrido de A. cherimólia e A. squamosa. Essas frutas têm alta aceitação pelo seu sabor e possibilidade de uso para consumo in natura, sucos e geleias. As áreas comercialmente cultivadas são concentradas nos Estados do Nordeste do Brasil. Os Estados de maior concentração: Bahia para graviola e pinha, Alagoas para pinha e São Paulo para atemoia. Os resultados de pesquisa envolvendo toda a cadeia produtiva dessas

  7. Application of the pyrochemical DOS, developed by the CEA, within reprocessing of CERCER transmutation fuel targets

    Energy Technology Data Exchange (ETDEWEB)

    Mendes, E.; Ducasse, T.; Bertrand, M. [CEA, Centre de Marcoule, Nuclear Energy Division, Radiochemistry and Processes Department, SMCS, LDPS, F-30207 Bagnols-sur-Ceze (France); Miguirditchian, M. [CEA, Centre de Marcoule, Nuclear Energy Division, Radiochemistry and Processes Department, SMCS, LCPE, F-30207 Bagnols-sur-Ceze (France)

    2016-07-01

    Pyrochemical technology using high-temperature molten salts and molten metal media presents a potential interest for an overall separation and transmutation strategy for long-lived radionuclides. Within the frame of the two French acts on radioactive waste management, a pyrochemical research/development program was launched at the CEA Marcoule in the late 90's. The second step is the actinides back-extraction, which consists in a liquid/liquid oxidative stripping of the An from aluminium matrix into molten chloride media. The DOS process has been successfully demonstrated for treatment of oxide type fuels within the last years: the core of the process has been already assessed and the studies have shown high selectivity and a quantitative recovery of actinides. Within the framework of the SACSESS European research program, the pyrochemical activities focused on applications of the DOS process to reprocess CERCER transmutation targets. These particular types of fuels consist of a mixture of minor actinides (MA) oxides diluted in an inert (oxide MgO) matrices. The behaviour of matrices material was first investigated regarding the solubility in the fluoride salt, starting from both oxide powders or sintered pellets. The saturation of Mg in the salt could be estimated at ∼ 3 wt%. Regarding the reductive extraction, as expected no Mg was reduced by the metallic phase. The present work also highlights that Mg has low impact on the extraction efficiency of U as long as the salt is not saturated. Once the saturation occurs, the efficiency starts to decrease. So we recommend recycling the salt when Mg saturation is reached.

  8. Design of the helium cooled lithium lead breeding blanket in CEA: from TBM to DEMO

    Science.gov (United States)

    Aiello, G.; Aubert, J.; Forest, L.; Jaboulay, J.-C.; Li Puma, A.; Boccaccini, L. V.

    2017-04-01

    The helium cooled lithium lead (HCLL) blanket concept was originally developed in CEA at the beginning of 2000: it is one of the two European blanket concepts to be tested in ITER in the form of a test blanket module (TBM) and one of the four blanket concepts currently being considered for the DEMOnstration reactor that will follow ITER. The TBM is a highly optimized component for the ITER environment that will provide crucial information for the development of the DEMO blanket, but its design needs to be adapted to the DEMO reactor. With respect to the TBM design, reduction of the steel content in the breeding zone (BZ) is sought in order to maximize tritium breeding reactions. Different options are being studied, with the potential of reaching tritium breeding ratio (TBR) values up to 1.21. At the same time, the design of the back supporting structure (BSS), which is a DEMO specific component that has to support the blanket modules inside the vacuum vessel (VV), is ongoing with the aim of maximizing the shielding power and minimizing pumping power. This implies a re-engineering of the modules’ attachment system. Design changes however, will have an impact on the manufacturing and assembly sequences that are being developed for the HCLL-TBM. Due to the differences in joint configurations, thicknesses to be welded, heat dissipation and the various technical constraints related to the accessibility of the welding tools and implementation of non-destructive examination (NDE), the manufacturing procedure should be adapted and optimized for DEMO design. Laser welding instead of TIG could be an option to reduce distortions. The time-of-flight diffraction (TOFD) technique is being investigated for NDE. Finally, essential information expected from the HCLL-TBM program that will be needed to finalize the DEMO design is discussed.

  9. First ITER Council convened in Cadarache - historic step in the quest for clean Energy 28 November 2007 Cadarache

    CERN Multimedia

    Hay, Jennifer

    2007-01-01

    "On 27 November 2007, the ITER Council convened for the first time in the history of the new International Organization. Opening the meeting, Dr Werner Burkart, Deputy Director of the International Atomic Energy Agency (AIEA), said: "Let me congratulate all who have contributed to the achievements of the ITER initiative to date.... (1,5 page)

  10. Actinides exposure: review of Ca-DTPA injections inside Cea-Cogema plants; Exposition aux actinides: bilan des injections de Ca-DTPA dans les centres CEA-Cogema

    Energy Technology Data Exchange (ETDEWEB)

    Grappin, L.; Berard, P.; Beau, P.; Carbone, L.; Castagnet, X.; Courtay, C.; Le Goff, J.P.; Menetrier, F.; Neron, M.; Piechowski, J. [CEA Cadarache, Dir. de l' Energie Nucleaire, Dept. de Soutien en surete et securite, Sev. de Sante au Travail, 13 - Saint-Paul-lez-Durance (France)

    2006-07-01

    Ca-DTPA has been used for medical treatment of plutonium and americium contaminations in the CEA and COGEMA plants from 1970 to 2003. This report is a survey of the injections administered of Ca-DTPA as a chelating molecule. This report will be a part of the AMM process for Ca-DTPA by intravenous administration submitted by the Central Pharmacy of the french Army. Out of 1158 injections administered to 469 persons, 548 events of possible or confirmed contaminations were reported. These employees were followed by occupational physicians according to the current regulations. The first part of the report is a synthesis of the most recent findings. Due to its short biological period and its limited action in the blood, Ca-DTPA does not chelate with plutonium and americium as soon as these elements are deposited in the target organs. It justifies an early treatment, even in cases of suspected contamination followed by additional injections if necessary. The second part presents data concerning these 1158 injections (way of contamination, posology, adverse effects...). These incidents took place at work, were most often minor, not requiring follow-up treatment. A study concerning the effectiveness of the product was done on a group of people having received 5 or more injections. These results were compared with effectiveness estimated from theoretical basis. Posologies and therapeutic schemes were proposed based on these observations. Additional studies are needed to confirm these findings. This document is the first synthesis in this field. It is the result of a collective work having mobilized the occupational medicine departments, the laboratories of CEA and COGEMA and a working group CEA-COGEMA-SPRA. (authors)

  11. LAS GESNERIÁCEAS DEL DEPARTAMENTO DEL QUINDÍO, COLOMBIA

    Directory of Open Access Journals (Sweden)

    Oscar Humberto Marín-Goméz

    2014-12-01

    Full Text Available Colombia es el país neotropical con mayor diversidad de Gesneriaceae. Sin embargo hay vacíos en el conocimiento de los patrones de distribución y ecología de esta familia, debido a su complejidad taxonómica. En este trabajo se presenta una lista de Gesneriaceae para el departamento del Quindío con datos de hábitat y distribución altitudinal. Se revisaron las colecciones del COL y HUQ y se realizó trabajo de campo entre 2009 y 2014 en 70 localidades del Quindío. Se encontraron 43 especies y 11 géneros, con una mayor representación de Columnea, Besleria y Kohleria; nueve especies fueron nuevos registros para el Quindío, tres fueron endémicas y cinco especies nuevas para la ciencia. La mayor riqueza se encontró en los bosques montanos entre 1800 m y 2400 m, principalmente en interior bosque y cañadas. Los resultados de este trabajo constituyen una línea base para dirigir la investigación en ecología, conservación y su potencial ornamental de las gesneriáceas presentes en el Quindío.ABSTRACTColombia is the most diverse Neotropical country of Gesneriaceae. Nevertheless, there are gaps in knowledge of the distribution patterns and ecology of this family because of their taxonomic complexity. A list of the Gesneriaceae of the Quindío department with data for habitat and altitudinal distribution is presented in this paper. The herbarium collections of COL and HUQ were reviewed and fieldwork was carried out between 2009 and 2014 in 70 localities of Quindío. Forty three species and 11 genera were found, with a larger representation of Columnea, Besleria and Kohleria genera; nine species were new records for the Quindío; three were endemic and five species are new to science. The greatest richness was found in the montane forest between 1800 m and 2400 m, mainly in forested areas and streams. The results of this work constitute a baseline to conduct research in ecology, conservation and ornamental potential of Gesneriaceae

  12. HgCdTe APD- focal plane array development at CEA Leti-Minatec

    Science.gov (United States)

    Rothman, Johan; Perrais, Gwladys; De Borniol, Eric; Castelein, Pierre; Baier, Nicholas; Guellec, Fabrice; Tchagaspanian, Michael; Ballet, Philippe; Mollard, Laurent; Gout, Sylvain; Perez, André; Fournier, Maryse; Chamonal, Jean-Paul; Tribolet, Philippe M.; Destefanis, Gerard

    2008-04-01

    We report the latest developments of MW HgCdTe electron initiated avalanche photo-diodes (e-APDs) focal plane arrays (FPAs) at CEA-LETI. The MW e-APD FPAs are developed in view of ultra-sensitive high dynamic range passive starring arrays, active 2D/3D and dual-mode passive-active imaging, which is why both the passive imaging performance and the gain characteristics of the APDs are of interest. A passive mode responsivity operability of 99.9% was measured in LPE and MBE e-APDs FPAs associated with an average NETD=12mK, demonstrating that dual mode passive-active imaging can be achieved with LETI e-APDs without degradation in the passive imaging performance. The gain and sensitivity performances were measured in test arrays and using a low voltage technology (3.3V) CTIA test pixel designed for 3D active imaging. The CTIA and test arrays measurements yielded comparable results in terms of bias gain dependence (M=100 at V b=-7V), low excess noise factor (=1.2) and low equivalent input current (I eq_in100, associated with an operability of 99%. The operability at I eq_in<1pA at M=30 was 95%. A record low value of Ieq_in=1fA was estimated in the MBE e-APDs at M=100, indicating the potential for using the MW e-APDs for very low flux applications. The high potential of the MW e-APDS for active imaging was demonstrated by impulse response measurements which yielded a typical rise time lower than 100ps and diffusion limited fall time of 900ps to 5ns, depending on the pixel pitch. This potential was confirmed by the demonstration of a 2ns time of flight (TOF) resolution in the CTIA e-APD 3D pixel. The combined photon and dark current induced equivalent back ground noise at f/8 with a cold band pass filter at λ=1.55μm was 2 electrons rms for an integration time of 50ns.

  13. Super-Phenix benchmark used for comparison of PNC and CEA calculation methods, and of JENDL-3.2 and CARNAVAL IV nuclear data

    Energy Technology Data Exchange (ETDEWEB)

    Hunter, S.N. [Power Reactor and Nuclear Fuel Development Corp., Oarai, Ibaraki (Japan). Oarai Engineering Center

    1998-02-01

    The study was carried out within the framework of the PNC-CEA collaboration agreement. Data were provided, by CEA, for an experimental loading of a start-up core in Super-Phenix. This data was used at PNC to produce core flux snapshot calculations. CEA undertook a comparison of the PNC results with the equivalent calculations carried out by CEA, and also with experimental measurements from SPX. The results revealed a systematic radial flux tilt between the calculations and the reactor measurements, with the PNC tilts only {approx}30-40% of those from CEA. CEA carried out an analysis of the component causes of the radial tilt. It was concluded that a major cause of radial tilt differences between the PNC and CEA calculations lay in the nuclear datasets used: JENDL-3.2 and CARNAVAL IV. For the final stage of the study, PNC undertook a sensitivity analysis, to examine the detailed differences between the two sets of nuclear data. The sensitivity analysis showed that a relatively small number of nuclear data items contributed the bulk of the radial tilt difference between calculations with JENDL-3.2 and with CARNAVAL IV. A direct comparison between JENDL-3.2 and CARNAVAL IV data revealed the following. The Nu values showed little difference. The only large fission cross-section differences were at low energy. Although down-scattering reactions showed some large fractional differences, absolute differences were negligible compared with in-group scattering; for in-group scattering fractional differences were up to {approx}75%, but generally <20%. There were many large differences in capture cross-sections, generally {approx}30-200%. (J.P.N.)

  14. Relationship between peripheral and mesenteric serum levels of CEA and CA 242 with staging and histopathological variables in colorectal adenocarcinoma Níveis séricos periféricos e mesentéricos de CEA e CA 242, estadiamento e variáveis histopatológicas no adenocarcinoma colorretal

    Directory of Open Access Journals (Sweden)

    Mauro Lamelas Cardoso

    2009-10-01

    Full Text Available PURPOSE: To compare histopathological variables and staging in colorectal adenocarcinoma cases with CEA and CA 242 in peripheral and mesenteric blood. METHODS: In 169 individuals underwent surgery for colorectal cancer, CEA and CA 242 were analyzed and compared to mesenteric and peripheral blood and correlated with macroscopic tumor's morphology and size, degree of cell differentiation, venous, neural and lymphatic involvement and TNM classification. RESULTS: There was a difference between the mesenteric (M and peripheral (P serum levels of CEA (p=0.020. Higher levels of markers were correlated with venous invasion CEA (P p=0.013, CEA (M p=0.05, CA 242 (M p=0.005 and CA 242 (P p=0.038; with advanced staging CEA (P OBJETIVO: Comparar variáveis histopatológicas e graus de estadiamento do adenocarcinoma colorretal com níveis sanguíneos periféricos e mesentéricos de CEA e CA-242. MÉTODOS: Em 169 doentes submetidos ao tratamento cirúrgico por adenocarcinoma colorretal, CEA e CA-242 foram analisados e comparados quanto aos níveis sanguíneos periféricos e mesentéricos e correlacionados com o tamanho e a morfologia macroscópica do tumor, grau de diferenciação celular, invasões venosa, linfática, neural e a classificação TNM. RESULTADOS: Verificou-se diferença significante entre o nível sérico mesentérico e periférico de CEA (p= 0,02. Níveis séricos mais elevados dos marcadores foram observados e correlacionados com invasão venosa, CEA (P p=0,013, CEA(M, p=0,05, CA-242 (M p=0,005 e CA-242 (P p=0,038. Grau de estadiamento TNM avançado foi associado com CEA(P < CEA(M p<0,05, CA-242(P < CA-242(M p<0,05. Nas maiores dimensões tumorais constatou-se CEA(P < CEA(M p=0,001 e CA 242 (P < CA 242 (M (p < 0.001. O CA 242 periférico e mesentérico aumentados associaram-se com a invasão neural, p=0.014 e p=0.003, respectivamente. CONCLUSÕES: O nível sérico mesentérico de CEA é superior ao nível sérico periférico. Os níveis s

  15. Efeito da cobertura viva com leguminosas herbáceas perenes na agregação de um argissolo

    OpenAIRE

    Perin, A; Guerra, J. G. M.; M. G. Teixeira; Pereira, M. G.; Fontana, A

    2002-01-01

    O presente trabalho foi desenvolvido na área do Campo Experimental da Embrapa Agrobiologia, Seropédica (RJ), com o objetivo de avaliar a morfologia e a distribuição de raízes de algumas leguminosas herbáceas perenes; os efeitos da cobertura viva no teor de carbono orgânico, e a agregação de um Argissolo Vermelho-Amarelo distrófico, medida pela estabilidade dos agregados em água. O delineamento experimental adotado foi o de blocos casualizados, com três repetições. Os tratamentos consistiram d...

  16. Influencia de la adición, en diferentes proporciones, de rocas silíceas opalinas al cemento portland

    OpenAIRE

    de Luxan, M. P.; Sánchez de Rojas, M. I.; Frías, M.; Saavedra, J.; Martín Patino, M. T.; Madruga, F.

    1989-01-01

    En este trabajo se estudia la influencia de la presencia de rocas silíceas opalinas, procedentes de las provincias de Salamanca, Zamora y Avila, en las propiedades de los cementos mixtos fabricados con cemento portland y proporciones variables de estas rocas utilizadas como adiciones activas. La caracterización de estos materiales y el estudio de las propiedades de los cementos preparados revelan la capacidad puzolánica de las rocas opalinas, y su singularidad respecto a otras puzolanas n...

  17. Detection of shock-heated hydrogen peroxide (H2O2) by off-axis cavity-enhanced absorption spectroscopy (OA-CEAS)

    Science.gov (United States)

    Alquaity, Awad B. S.; KC, Utsav; Popov, Alber; Farooq, Aamir

    2017-12-01

    Cavity-enhanced absorption spectroscopy (CEAS) is a promising technique for studying chemical reactions due to its desirable characteristics of high sensitivity and fast time-response by virtue of the increased path length and relatively short photon residence time inside the cavity. Off-axis CEAS (OA-CEAS) is particularly suited for the shock tube applications as it is insensitive to slight misalignments, and cavity noise is suppressed due to non-overlapping multiple reflections of the probe beam inside the cavity. Here, OA-CEAS is demonstrated in the mid-IR region at 1310.068 cm-1 to monitor trace concentrations of hydrogen peroxide (H2O2). This particular probe frequency was chosen to minimize interference from other species prevalent in combustion systems and in the atmosphere. The noise-equivalent detection limit is found to be 3.25 × 10-5 cm-1, and the gain factor of the cavity is 131. This corresponds to a detection limit of 74 ppm of H2O2 at typical high-temperature combustion conditions (1200 K and 1 atm) and 12 ppm of H2O2 at ambient conditions (296 K and 1 atm). To our knowledge, this is the first successful application of the OA-CEAS technique to detect H2O2 which is vital species in combustion and atmospheric science.

  18. Detection of shock-heated hydrogen peroxide (H2O2) by off-axis cavity-enhanced absorption spectroscopy (OA-CEAS)

    KAUST Repository

    Alquaity, Awad

    2017-11-11

    Cavity-enhanced absorption spectroscopy (CEAS) is a promising technique for studying chemical reactions due to its desirable characteristics of high sensitivity and fast time-response by virtue of the increased path length and relatively short photon residence time inside the cavity. Off-axis CEAS (OA-CEAS) is particularly suited for the shock tube applications as it is insensitive to slight misalignments, and cavity noise is suppressed due to non-overlapping multiple reflections of the probe beam inside the cavity. Here, OA-CEAS is demonstrated in the mid-IR region at 1310.068 cm−1 to monitor trace concentrations of hydrogen peroxide (H2O2). This particular probe frequency was chosen to minimize interference from other species prevalent in combustion systems and in the atmosphere. The noise-equivalent detection limit is found to be 3.25 × 10−5 cm−1, and the gain factor of the cavity is 131. This corresponds to a detection limit of 74 ppm of H2O2 at typical high-temperature combustion conditions (1200 K and 1 atm) and 12 ppm of H2O2 at ambient conditions (296 K and 1 atm). To our knowledge, this is the first successful application of the OA-CEAS technique to detect H2O2 which is vital species in combustion and atmospheric science.

  19. Novel Application of Cultured Epithelial Autografts (CEA with Expanded Mesh Skin Grafting Over an Artificial Dermis or Dermal Wound Bed Preparation

    Directory of Open Access Journals (Sweden)

    Sadanori Akita

    2017-12-01

    Full Text Available Cultured epithelial autografts (CEA with highly expanded mesh skin grafts were used for extensive adult burns covering more than 30% of the total body surface area. A prospective study on eight patients assessed subjective and objective findings up to a 12-month follow-up. The results of wound healing for over 1:6 mesh plus CEA, gap 1:6 mesh plus CEA, and 1:3 mesh were compared at 3, 6, and 12 months using extensibility, viscoelasticity, color, and transepidermal water loss by a generalized estimating equation (GEE or generalized linear mixed model (GLMM. No significant differences were observed among the paired treatments at any time point. At 6 and 12 months, over 1:6 mesh plus CEA achieved significantly better expert evaluation scores by the Vancouver and Manchester Scar Scales (p < 0.01. Extended skin grafting plus CEA minimizes donor resources and the quality of scars is equal or similar to that with conventional low extended mesh slit-thickness skin grafting such as 1:3 mesh. A longitudinal analysis of scars may further clarify the molecular changes of scar formation and pathogenesis.

  20. Brain metastasis development and poor survival associated with carcinoembryonic antigen (CEA) level in advanced non-small cell lung cancer: a prospective analysis.

    Science.gov (United States)

    Arrieta, Oscar; Saavedra-Perez, David; Kuri, Roberto; Aviles-Salas, Alejandro; Martinez, Luis; Mendoza-Posada, Daniel; Castillo, Patricia; Astorga, Alma; Guzman, Enrique; De la Garza, Jaime

    2009-04-22

    Central nervous system is a common site of metastasis in NSCLC and confers worse prognosis and quality of life. The aim of this prospective study was to evaluate the prognostic significance of clinical-pathological factors (CPF), serum CEA levels, and EGFR and HER2 tissue-expression in brain metastasis (BM) and overall survival (OS) in patients with advanced NSCLC. In a prospective manner, we studied 293 patients with NSCLC in IIIB-IV clinical stage. They received standard chemotherapy. CEA was measured prior to treatment; EGFR and HER2 were evaluated by immunohistochemistry. BM development was confirmed by MRI in symptomatic patients. BM developed in 27, and 32% of patients at 1 and 2 years of diagnosis with adenocarcinoma (RR 5.2; 95% CI, 1.002-29; p = 0.05) and CEA > or = 40 ng/mL (RR 11.4; 95% CI, 1.7-74; p or = 40 ng/mL (RR 1.5; 95% CI, 1.09-2.2; p = 0.014) and EGFR expression (RR 1.6; 95% CI, 1.4-1.9; p = 0.012) were independent associated factors to worse OS. High CEA serum level is a risk factor for BM development and is associated with poor prognosis in patients with advanced NSCLC. Surface expression of CEA in tumor cells could be the physiopathological mechanism for invasion to CNS.

  1. Utility of CEA and CA 15-3 measurements in non-purulent pleural exudates in the diagnosis of malignancy: A single-center experience.

    Science.gov (United States)

    Porcel, José M; Civit, Carme; Esquerda, Aureli; Salud, Antonieta; Bielsa, Silvia

    2017-08-01

    To establish the diagnostic accuracy of pleural fluid (PF) CEA and CA 15-3 in identifying malignancy, and to determine the additional value of these markers in patients with malignant pleural effusions (MPEs) with false negative results from cytological fluid examination. PF concentrations of CEA and/or CA 15-3 were determined in 1,575 patients with non-purulent exudates, 549 of whom had confirmed MPEs, 284 probable MPEs, and 742 benign effusions. Tumor marker cut-off points were set to ensure 100% specificity for malignant effusion. The 41, 40 and 60% of MPE patients had high PF levels of CEA (>45ng/mL), CA 15-3 (>77 UI/l) or both, respectively. These percentages were 30, 19 and 41% in MPEs with positive pleural biopsy and negative PF cytology; and 24, 13 and 35% in clinical MPEs without histocytological confirmation. Tumor markers were of no value in lymphomas and mesotheliomas. The area-under-the-curve for CEA was 0.819 (95% CI: 0,793-0,845) and for CA 15-3, it was 0.822 (95% CI: 0,796-0,847). The use of tumor markers compared to cytology alone, increased the diagnosis of malignancy by 14%. Measurements of PF CEA and CA 15-3 may complement pleural cytology in the identification of MPEs. Copyright © 2017 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved.

  2. Neutron Activation Foil and Thermoluminescent Dosimeter Responses to a Polyethylene Reflected Pulse of the CEA Valduc SILENE Critical Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Thomas Martin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Celik, Cihangir [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McMahan, Kimberly L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lee, Yi-kang [French Atomic Energy Commission (CEA), Saclay (France); Gagnier, Emmanuel [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette; Authier, Nicolas [French Atomic Energy Commission (CEA), Salives (France). Valduc Centre for Nuclear Studies; Piot, Jerome [French Atomic Energy Commission (CEA), Salives (France). Valduc Centre for Nuclear Studies; Jacquet, Xavier [French Atomic Energy Commission (CEA), Salives (France). Valduc Centre for Nuclear Studies; Rousseau, Guillaume [French Atomic Energy Commission (CEA), Salives (France). Valduc Centre for Nuclear Studies; Reynolds, Kevin H. [Y-12 National Security Complex, Oak Ridge, TN (United States)

    2016-09-01

    This benchmark experiment was conducted as a joint venture between the US Department of Energy (DOE) and the French Commissariat à l'Energie Atomique (CEA). Staff at the Oak Ridge National Laboratory (ORNL) in the US and the Centre de Valduc in France planned this experiment. The experiment was conducted on October 19, 2010 in the SILENE critical assembly facility at Valduc. Several other organizations contributed to this experiment and the subsequent evaluation, including CEA Saclay, Lawrence Livermore National Laboratory (LLNL), the Y-12 National Security Complex (NSC), Babcock International Group in the United Kingdom, and Los Alamos National Laboratory (LANL). The goal of this experiment was to measure neutron activation and thermoluminescent dosimeter (TLD) doses from a source similar to a fissile solution critical excursion. The resulting benchmark can be used for validation of computer codes and nuclear data libraries as required when performing analysis of criticality accident alarm systems (CAASs). A secondary goal of this experiment was to qualitatively test performance of two CAAS detectors similar to those currently and formerly in use in some US DOE facilities. The detectors tested were the CIDAS MkX and the Rocky Flats NCD-91. The CIDAS detects gammas with a Geiger-Muller tube and the Rocky Flats detects neutrons via charged particles produced in a thin 6LiF disc depositing energy in a Si solid state detector. These detectors were being evaluated to determine whether they would alarm, so they were not expected to generate benchmark quality data.

  3. Neutron Activation and Thermoluminescent Detector Responses to a Bare Pulse of the CEA Valduc SILENE Critical Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Thomas Martin [ORNL; Isbell, Kimberly McMahan [ORNL; Lee, Yi-kang [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette; Gagnier, Emmanuel [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette; Authier, Nicolas [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille; Piot, Jerome [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille; Jacquet, Xavier [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille; Rousseau, Guillaume [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille; Reynolds, Kevin H. [Y-12 National Security Complex

    2016-09-01

    This benchmark experiment was conducted as a joint venture between the US Department of Energy (DOE) and the French Commissariat à l'Energie Atomique (CEA). Staff at the Oak Ridge National Laboratory (ORNL) in the US and the Centre de Valduc in France planned this experiment. The experiment was conducted on October 11, 2010 in the SILENE critical assembly facility at Valduc. Several other organizations contributed to this experiment and the subsequent evaluation, including CEA Saclay, Lawrence Livermore National Laboratory (LLNL), the Y-12 National Security Complex (NSC), Babcock International Group in the United Kingdom, and Los Alamos National Laboratory (LANL). The goal of this experiment was to measure neutron activation and thermoluminescent dosimeter (TLD) doses from a source similar to a fissile solution critical excursion. The resulting benchmark can be used for validation of computer codes and nuclear data libraries as required when performing analysis of criticality accident alarm systems (CAASs). A secondary goal of this experiment was to qualitatively test performance of two CAAS detectors similar to those currently and formerly in use in some US DOE facilities. The detectors tested were the CIDAS MkX and the Rocky Flats NCD-91. These detectors were being evaluated to determine whether they would alarm, so they were not expected to generate benchmark quality data.

  4. Superar la frontera: mecanismos de integración territorial entre el Cea y el Pisuerga en el siglo X

    Directory of Open Access Journals (Sweden)

    Carvajal Castro, Álvaro

    2012-12-01

    Full Text Available The different territorial structures that developed in the region between the Cea and the Pisuerga rivers during the 10th century were the outcome of particular processes in the production of space. The study of their formalization within the astur-leonese institutional framework will help us to analyze the political resources and mechanisms employed by both the monarchy and the main regional elites in order to strengthen their power. Ultimately, it will help us to get a better understanding of the processes of territorial integration that took place as the astur-leonese kingdom expanded over the Duero plateau during the Early Middle Ages.

    Las diferentes estructuras territoriales que se desarrollaron entre el Cea y el Pisuerga en el siglo X fueron fruto de procesos de producción del espacio particulares. El estudio de su formalización en el marco institucional asturleonés nos ayudará a analizar los recursos y mecanismos políticos empleados por la monarquía y los poderes territoriales principales para consolidar su poder. En último término, nos permitirá comprender mejor los procesos de integración territorial que tuvieron lugar como consecuencia de la expansión de la monarquía asturleonesa sobre la Meseta del Duero en la Alta Edad Media.

  5. L-dopa, biperideno e excreção sebácea na doença de Parkinson

    Directory of Open Access Journals (Sweden)

    João C. B. Villares

    1989-03-01

    Full Text Available A excreção sebácea frontal de 47 parkinsonianos «de novo» antes e após tratamento com anticolinérgico (biperideno, levodopa + IDAA e bromocriptina foi avaliada pelo método do ácido ósmico. Outros 100 parkinsonianos sob terapêutica crônica com biperideno, levodopa + IDAA ou associação de ambos foram avaliados. Parkinsonianos «de novo» do sexo masculino apresentam valores de excreção sebácea significativamente mais elevados em relação às mulheres. Verificou-se que biperideno não foi eficaz em reduzir o grau de excreção sebácea. Já, em relação a L-dopa + IDAA constatou-se que a droga foi efetiva em reduzir o grau de excreção sebácea (NC e TRE tanto no sexo masculino quanto no feminino. Em relação à bromocriptina (l0mg/dia também constatou-se que houve redução da excreção sebácea no sexo masculino. Correlação significante positiva foi verificada entre o NC, tremor, bradicinesia, hipertonia, alterações da marcha e postura e incapacidade funcional, entre parkinsonianos do sexo masculino e faixa etária 50-59 anos, no período pré-tratamento. Após o período de tratamento não mais havia correlação entre excreção sebácea e as manifestações neurológicas da doença de Parkinson. Entre parkinsonianos sob terapêutica crônica verificou-se correlação positiva e significante entre excreção sebácea e bradicinesia. O grau de excreção sebácea de parkinsonianos «de novo» sem tratamento não difere do grau daqueles sob tratamento crônico, exceção feita a parkinsonianos com idade > 60 anos, em que verificou-se maior grau de excreção sebácea (NC e TRE em relação ao mesmo sexo e faixa etária, sem tratamento. L-dopa + IDAA foi eficiente em reduzir o grau de excreção sebácea de parkinsonianos «de novo», tornando-a significativamente menor em relação àqueles sob tratamento crônico. Não há diferença entre o grau de excreção sebácea de parkinsonianos «de novo» sem tratamento e

  6. The Potential Ability of Plaster to Cause Breast Cancer as Indicated by CA15-3 and CEA Antigens in Women Working in Gypsum Factory

    Directory of Open Access Journals (Sweden)

    Ali Abdul Hussein S. AL-Janabi

    2017-07-01

    Full Text Available Plaster is an important form of gypsum that mainly used in building construction. Breast cancer was investigated among women exposure to the dust of such material. The levels of CA15-3 and carcinoembryonic antigens (CEA as indicators for breast cancer were measured in the serum of 120 women working in a plaster factory. All of involved women showed a normal level of CEA, while 12.5% of them had moderately elevated levels of CA15-3. In conclusion; plaster dust has no significant effect to cause breast cancer in working women. Moderately high levels of CA15-3 in some of exposed women may relate to liver diseases. Key words: Breast Cancer, Plaster, CA15-3, CEA

  7. Brain metastasis development and poor survival associated with carcinoembryonic antigen (CEA level in advanced non-small cell lung cancer: a prospective analysis

    Directory of Open Access Journals (Sweden)

    Castillo Patricia

    2009-04-01

    Full Text Available Abstract Background Central nervous system is a common site of metastasis in NSCLC and confers worse prognosis and quality of life. The aim of this prospective study was to evaluate the prognostic significance of clinical-pathological factors (CPF, serum CEA levels, and EGFR and HER2 tissue-expression in brain metastasis (BM and overall survival (OS in patients with advanced NSCLC. Methods In a prospective manner, we studied 293 patients with NSCLC in IIIB-IV clinical stage. They received standard chemotherapy. CEA was measured prior to treatment; EGFR and HER2 were evaluated by immunohistochemistry. BM development was confirmed by MRI in symptomatic patients. Results BM developed in 27, and 32% of patients at 1 and 2 years of diagnosis with adenocarcinoma (RR 5.2; 95% CI, 1.002–29; p = 0.05 and CEA ≥ 40 ng/mL (RR 11.4; 95% CI, 1.7–74; p p = 0.048, poor performance status (RR 1.8; 95% CI, 1.5–2.3; p = 0.002, advanced clinical stage (RR 1.44; 95% CI, 1.02–2; p = 0.04, CEA ≥ 40 ng/mL (RR 1.5; 95% CI, 1.09–2.2; p = 0.014 and EGFR expression (RR 1.6; 95% CI, 1.4–1.9; p = 0.012 were independent associated factors to worse OS. Conclusion High CEA serum level is a risk factor for BM development and is associated with poor prognosis in patients with advanced NSCLC. Surface expression of CEA in tumor cells could be the physiopathological mechanism for invasion to CNS.

  8. Effect of rabdosia rubescens combined with new assistant chemotherapy on serum CA199, CEA, CA15-3 and T lymphocyte subsets in patients with breast cancer

    Directory of Open Access Journals (Sweden)

    Lei Xi

    2018-07-01

    Full Text Available Objective: To study the effects of Rabdosia rubescens combined with neoadjuvant chemotherapy on serum CA199, CEA, CA15-3 levels and T lymphocyte subsets in patients with breast cancer. Methods: A total of 70 patients with breast cancer in our hospital were enrolled as the subjects of this study. The subjects were divided into control group (n=35 and treatment group (n=35 randomly. Patients in the control group were treated with new assistant chemotherapy, while those who were in the treatment group were treated with rabdosia rubescens combined with new assistant chemotherapy. The two groups of patients were treated for 3 periods. The serum CA199, CEA, CA15-3 levels and peripheral blood CD4+, CD8+, CD4+/CD8+ cells of the two groups before and after treatment were compared. Results: There were no significantly differences among the serum CA199, CEA, CA15-3 levels and peripheral blood CD4+, CD8+, CD4+/CD8+ cells of the two groups before treatment. The serum CA199, CEA and CA15-3 levels of the two groups after treatment were significantly lower than those before treatment, besides, the serum CA199, CEA and CA15-3 levels of the treatment group were significantly lower than those of the control group. The peripheral blood CD4+, CD4+/ CD8+ cells of the control group after treatment were significantly lower than before treatment, and the peripheral blood CD4+, CD4+/CD8+ cells of the treatment group after treatment were significantly higher than those of the control group. Conclusion: Rabdosia rubescens combined with new assistant chemotherapycan can significantly reduce the serum CA199, CEA and CA15-3 levels, and improve peripheral blood CD4+, CD8+, CD4+/CD8+ levels of patients with breast cancer. It is worthy of clinical application.

  9. Value of {sup 18}F-FDG uptake on PET/CT and CEA level to predict epidermal growth factor receptor mutations in pulmonary adenocarcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Kai-Hsiung; Hsu, Hsian-He; Chang, Wei-Chou; Hsu, Yi-Chih; Chang, Tsun-Hou [Tri-Service General Hospital and National Defense Medical Center, Department of Radiology, Taipei 114 (China); Huang, Tsai-Wang; Chang, Hung [Tri-Service General Hospital and National Defense Medical Center, Department of Thoracic Surgery, Taipei (China); Gao, Hong-Wei [Tri-Service General Hospital and National Defense Medical Center, Department of Pathology, Taipei (China); Shen, Daniel H.Y. [Tri-Service General Hospital and National Defense Medical Center, Department of Nuclear medicine, Taipei (China); Chu, Chi-Ming [Institute of Public Health, National Defense Medical Center and University, Section of Health Informatics, Taipei (China); Ho, Ching-Liang [Tri-Service General Hospital and National Defense Medical Center, Division of Hematology-Oncology, Department of Internal Medicine, Taipei (China)

    2014-10-15

    The identification of the mutation status of the epidermal growth factor receptor (EGFR) is important for the optimization of treatment in patients with pulmonary adenocarcinoma. The acquisition of adequate tissues for EGFR mutational analysis is sometimes not feasible, especially in advanced-stage patients. The aim of this study was to predict EGFR mutation status in patients with pulmonary adenocarcinoma based on {sup 18}F-fluorodeoxyglucose (FDG) uptake and imaging features in positron emission tomography/computed tomography (PET/CT), as well as on the serum carcinoembryonic antigen (CEA) level. We retrospectively reviewed 132 pulmonary adenocarcinoma patients who underwent EGFR mutation testing, pretreatment FDG PET/CT and serum CEA analysis. The associations between EGFR mutations and patient characteristics, maximal standard uptake value (SUVmax) of primary tumors, serum CEA level and CT imaging features were analyzed. Receiver-operating characteristic (ROC) curve analysis was performed to quantify the predictive value of these factors. EGFR mutations were identified in 69 patients (52.2 %). Patients with SUVmax ≥6 (p = 0.002) and CEA level ≥5 (p = 0.013) were more likely to have EGFR mutations. The CT characteristics of larger tumors (≥3 cm) (p = 0.023) and tumors with a nonspiculated margin (p = 0.026) were also associated with EGFR mutations. Multivariate analysis showed that higher SUVmax and CEA level, never smoking and a nonspiculated tumor margin were the most significant predictors of EGFR mutation. The combined use of these four criteria yielded a higher area under the ROC curve (0.82), suggesting a good discrimination. The combined evaluation of FDG uptake, CEA level, smoking status and tumor margins may be helpful in predicting EGFR mutation status in patients with pulmonary adenocarcinoma, especially when the tumor sample is inadequate for genetic analysis or genetic testing is not available. Further large-scale prospective studies are

  10. Release monitoring and environmental surveillance of Cea centers. Assessment and regulation and method 1999; Controle des rejets et surveillance de l'environnement des centres CEA. Bilan et reglementation et methode 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    The quality of the natural environment around the centers of the Commissariat a l Energie Atomique is an important point of its safety policy. The environmental protection is based on the control of risks coming from research and development activities of its installations. It aims to reduce as low as possible, the impact of its activities on man and his environment. This publication develops the sampling and measurement methods that are made on effluents and in environment, according to the radionuclides characteristics, that are present. It gives also the regulation that applied to the effluents monitoring. The results of radioactive effluents releases (liquid and gaseous) and the surveillance of environment around cea centers is given in the 'Bilan 1999' publication. An analysis of these results on the 1995-1999 period allows to follow their evolution. (N.C.)

  11. INIS - International Nuclear Information System. CEA-users relations. Nuclear information in total freedom; INIS - International Nuclear Information System. Relations CEA utilisateurs. L'information nucleaire en toute liberte

    Energy Technology Data Exchange (ETDEWEB)

    Surmont, J.; Paillard, M.D.; Constant, A.; Guille, N.; Le Blanc, A.; Mouffron, O.; Anguise, P.; Jouve, J.J.; Lilin, A

    2009-07-01

    This poster, prepared for the seventh edition of the meetings of scientific and technical information professionals (RPIST, Nancy (France)), presents the principle of operation of the INIS system, based on a cooperative and decentralized preparation of the data which are centralized by the IAEA for the preparation of the INIS products: the database (on Internet and on CD/DVD-Rom), the collection of grey literature documents in full text (microfiches and CD/DVD-roms), and the multilingual thesaurus available in 7 different languages and under various formats. The poster presents these different products, and the role of the INIS members in the distribution of these products towards their national users. One insert presents the French INIS team of the CEA-Saclay and its daily work. (J.S.)

  12. Pharmacokinetics and Dosimetry Studies for Optimization of Pretargeted Radioimmunotherapy in CEA-Expressing Advanced Lung Cancer Patients

    Directory of Open Access Journals (Sweden)

    Caroline eBodet-Milin

    2015-11-01

    Full Text Available Objectives. A phase I pretargeted radioimmunotherapy trial (EudractCT 200800603096 was designed in patients with metastatic lung cancer expressing carcinoembryonic antigen (CEA to optimize bispecific antibody and labelled peptide doses, as well as the delay between their injections.Methods. Three cohorts of 3 patients received the anti-CEA x anti-histamine-succinyl-glycine (HSG humanized trivalent bispecific antibody (TF2 and the IMP288 bivalent HSG-peptide. Patients underwent a pre-therapeutic imaging session S1 (44 or 88 nmol/m2 of TF2 followed by 4.4 nmol/m2, 185 MBq, of 111In-labelled IMP288, and, 1-2 weeks later, a therapy session S2 (240 or 480 nmol/m2 of TF2 followed by 24 nmol/m2, 1.1 GBq/m2, 177Lu-labeled IMP288. The pretargeting delay was 24 or 48 hours. The dose schedule was defined based on pre-clinical TF2 pharmacokinetic studies, on our previous clinical data using the previous anti-CEA pretargeting system and on clinical results observed in the first patients injected using the same system in the Netherlands.Results. TF2 pharmacokinetics (PK was represented by a two-compartment model in which the central compartment volume was linearly dependent on the patient's surface area. PK were remarkably similar, with a clearance of 0.33 +/- 0.03 L/h per m2. 111In- and 177Lu-IMP288 PK were also well represented by a two-compartment model. IMP288 PK were faster (clearance 1.4 to 3.3 l/h. The central compartment volume was proportional to body surface area and IMP288clearance depended on the molar ratio of injected IMP288 to circulating TF2 at the time of IMP288 injection. Modelling of image quantification confirmed the dependence of IMP288 kinetics on circulating TF2, but tumour activity PK were variable. Organ absorbed doses were not significantly different in the 3 cohorts, but the tumour dose was significantly higher with the higher molar doses of TF2 (p < 0.002. S1 imaging predicted absorbed doses calculated in S2. Conclusion. The best

  13. Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA Gold 4 epitope and designed for radioimmunotherapy (RIT of colorectal cancers

    Directory of Open Access Journals (Sweden)

    Pugnière Martine

    2004-10-01

    Full Text Available Abstract Background Human monoclonal antibodies (MAbs are needed for colon cancer radioimmunotherapy (RIT to allow for repeated injections. Carcinoembryonic antigen (CEA being the reference antigen for immunotargeting of these tumors, we developed human anti-CEA MAbs. Methods XenoMouse®-G2 animals were immunized with CEA. Among all the antibodies produced, two of them, VG-IgG2κ and VG-IgM, were selected for characterization in vitro in comparison with the human-mouse chimeric anti-CEA MAb X4 using flow cytometry, surface plasmon resonance, and binding to radiolabeled soluble CEA and in vivo in human colon carcinoma LS174T bearing nude mice. Results Flow cytometry analysis demonstrated binding of MAbs on CEA-expressing cells without any binding on NCA-expressing human granulocytes. In a competitive binding assay using five reference MAbs, directed against the five Gold CEA epitopes, VG-IgG2κ and VG-IgM were shown to be directed against the Gold 4 epitope. The affinities of purified VG-IgG2κ and VG-IgM were determined to be 0.19 ± 0.06 × 108 M-1 and 1.30 ± 0.06 × 108 M-1, respectively, as compared with 0.61 ± 0.05 × 108 M-1 for the reference MAb X4. In a soluble phase assay, the binding capacities of VG-IgG2κ and VG-IgM to soluble CEA were clearly lower than that of the control chimeric MAb X4. A human MAb concentration of about 10-7 M was needed to precipitate approximatively 1 ng 125I-rhCEA as compared with 10-9 M for MAb X4, suggesting a preferential binding of the human MAbs to solid phase CEA. In vivo, 24 h post-injection, 125I-VG-IgG2κ demonstrated a high tumor uptake (25.4 ± 7.3%ID/g, close to that of 131I-X4 (21.7 ± 7.2%ID/g. At 72 h post-injection, 125I-VG-IgG2κ was still concentrated in the tumor (28.4 ± 11.0%ID/g whereas the tumor concentration of 131I-X4 was significantly reduced (12.5 ± 4.8%ID/g. At no time after injection was there any accumulation of the radiolabeled MAbs in normal tissues. A pertinent analysis of

  14. Cryogenic Operation on the R3B-Glad Large Acceptance Superconducting Dipole Spectrometer at CEA Saclay

    Science.gov (United States)

    Vallcorba, R.; Mayri, C.; Gastineau, B.; Maksoud, W. Abdel; Donati, A.; Genini, L.; Gibier, D.; Godon, P.; Lottin, J. P.; Mailleret, C.; Queinec, Y.

    The R3B-Glad magnet cold mass has been tested in the test facility at CEA Saclay previously used for testing W7X coils. This superconducting dipole has been cooled down by indirect cooling, and its 21 tons were maintained at around 4.8 K by means of helium thermosiphon. For this, the facility was adapted and connected to the cold mass to approximate actual conditions in its final configuration at GSI (Darmstadt, Germany). The magnet cooling down as well as the two-slope current ramping up to the nominal current of 3584 A was successfully achieved in December 2013. This paper presents the cryogenic distribution process, and shows the relevant results.

  15. Terahertz Real-Time Imaging Uncooled Arrays Based on Antenna-Coupled Bolometers or FET Developed at CEA-Leti

    Science.gov (United States)

    Simoens, François; Meilhan, Jérôme; Nicolas, Jean-Alain

    2015-10-01

    Sensitive and large-format terahertz focal plane arrays (FPAs) integrated in compact and hand-held cameras that deliver real-time terahertz (THz) imaging are required for many application fields, such as non-destructive testing (NDT), security, quality control of food, and agricultural products industry. Two technologies of uncooled THz arrays that are being studied at CEA-Leti, i.e., bolometer and complementary metal oxide semiconductor (CMOS) field effect transistors (FET), are able to meet these requirements. This paper reminds the followed technological approaches and focuses on the latest modeling and performance analysis. The capabilities of application of these arrays to NDT and security are then demonstrated with experimental tests. In particular, high technological maturity of the THz bolometer camera is illustrated with fast scanning of large field of view of opaque scenes achieved in a complete body scanner prototype.

  16. X-ray diffraction study on thermal properties of crystal lattices in CeP and CeAs

    Energy Technology Data Exchange (ETDEWEB)

    Iwasa, Kazuaki; Kohgi, Masafumi [Department of Physics, Faculty of Science, Tokyo Metropolitan University, Hachioji, Tokyo (Japan); Ohsumi, Hiroyuki; Tajima, Keisuke; Takeuchi, Tetsuya; Haga, Yoshinori; Uesawa, Akihiro; Suzuki, Takashi

    1999-03-01

    X-ray diffraction studies at low temperatures have been performed in order to investigate thermal properties of crystal lattices in the low-carrier-density systems cerium monopnictides. CeP and CeAs show large crystal-lattice contractions with increasing temperatures up to about 120K and 90K, respectively. Due to the strong p-f mixing, the excited crystal {Gamma}{sub 8}-like state is expected to produce a shorter interatomic bond length between cerium ions and neighboring pnictogens than that realized by the {Gamma}{sub 7} ground state. The experimental results of the lattice contractions at low temperatures are explained by the thermal average of these crystal field states. (author)

  17. Diatomáceas de tanques do cactário do Jardim Botânico, Guanabara, Brasil

    Directory of Open Access Journals (Sweden)

    Luis Tavares de Lyra

    1974-01-01

    Full Text Available O autor analisou a microflora de três tanques situados no Cactário do Jardim Botânico, Rio de Janeiro, Guanabara. Tanque nº 1. Apresentou desenvolvimento muito intenso da microfibra nos mseses mais frios. As diatomáceas foram muito freqüentes. As espécies indicadoras de saprobidade foram as seguintes: Gomphonema gracile Ehr., pinnularia maior. (kutz Cleve, Gomphonema parvulum (kutz Grunow, Navicula mutica Kutz., Pinnularia borealis Ehr., Pinnularia microstauron (Ehr Cleve, Pinnularia acrospheria Breb., Hantzschia amphioxys (Ehr Grunow, Nitzschia palea Kutz., Eutonia pectinalis (Kutz Rabenh. Tanque nº 2. As diatomáceas indicadoras de águas contaminadas, anotamos como segue: Eutonia pectinalis (Kutz Rabenh., Gomphonema parvulum (kutz Grunow, Hanstzschia amphioxys (Ehr Grunow, Navicula mutica Kutz, Pinnularia borealis Ehr., Pinnularia maior (Kutz Cleve, Pinnularia microstauron (Ehr Cleve. Tanque nº 3. Foi bastante reduzida a freqüência da microflora. Comparando-o com os tanques nº 1 e 2, as diatomáceas e clorofícias observadas, mostraram-se diminuídas nos meses mais quentes. Encontramos as seguintes espécies oligosaprobias: Eunotia pectinalis (Kutz Rabenh., Gomphonema gracile ehr., Gomphonema parvulum (Kutz Grunow Hantzschia amphioxys (Ehr Grunow, Pinnularia borealis Ehr., Pinnularia maior (Kutz Cleve. Foram consideradas também as clorofíceas quanto ao regime de saprobidade do material estudado. Eutonia augusta f. crenulata Cleve-Euler e Eutonia veneris var. exsecta Clever-Euler encontradas em nossas amostras, são novas para o Brasil. Um total de 71 espécies foram determinadas de 21 coletas realizadas durante o período de 36 meses.The author analysed the microflorafrom three ponds situated in the Cactarium from the Botanical Garden of Rio de Janeiro, Guanabara. Pond nº 1 - This pond showed a very intensive development of the microflora in the coldermonths. The diatoms were very frequent. Those diatoms that indicate saprobic

  18. Improvements on Low Level Activity Gamma Measurements and X-ray Spectrometry at the CEA-MADERE Measurement Platform

    Directory of Open Access Journals (Sweden)

    Sergeyeva Victoria

    2016-01-01

    Full Text Available The CEA MADERE platform (Measurement Applied to DosimEtry in REactors is a part of the Instrumentation Sensors and Dosimetry Laboratory (LDCI. This facility is dedicated to the specific activity measurements of solid and radioactive samples using Gamma and X-ray spectrometry. MADERE is a high-performance facility devoted to neutron dosimetry for experimental programs performed in CEA and for the irradiation surveillance programmes of PWR vessels. The MADERE platform is engaged in a continuous improvement process. Recently, two High Efficiency diodes have been integrated to the MADERE platform in order to manage the accurate low level activity measurements (few Bq per sample. This new equipment provides a good level of efficiency over the energy range from 60 keV to 2 MeV. The background continuum is reduced due to the use of a Ultra Low Background (ULB lead shielding. Relative and absolute X-ray measurement techniques have been improved in order to facilitate absolute rhodium activity measurement (Rh103m on solid samples. Additional efforts have been made to increase the accuracy of the relative niobium (Nb93m activity measurement technique. The way of setting up an absolute measurement method for niobium is under investigation. After a presentation of the MADERE's measurement devices, this paper focuses on the technological options taken into account for the design of high efficiency measurement devices. Then, studies performed on X-ray measurement techniques are presented. Some details about the calculation of uncertainties and correction factors are also mentioned. Finally, future research and development axes are exposed.

  19. Neutron Activation Foil and Thermoluminescent Dosimeter Responses to a Lead Reflected Pulse of the CEA Valduc SILENE Critical Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Thomas Martin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Celik, Cihangir [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Isbell, Kimberly McMahan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lee, Yi-kang [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Gagnier, Emmanuel [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Authier, Nicolas [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Piot, Jerome [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Jacquet, Xavier [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Rousseau, Guillaume [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Reynolds, Kevin H. [Y-12 National Security Complex, Oak Ridge, TN (United States)

    2016-09-01

    This benchmark experiment was conducted as a joint venture between the US Department of Energy (DOE) and the French Commissariat à l'Energie Atomique (CEA). Staff at the Oak Ridge National Laboratory (ORNL) in the US and the Centre de Valduc in France planned this experiment. The experiment was conducted on October 13, 2010 in the SILENE critical assembly facility at Valduc. Several other organizations contributed to this experiment and the subsequent evaluation, including CEA Saclay, Lawrence Livermore National Laboratory (LLNL), the Y-12 National Security Complex (NSC), Babcock International Group in the United Kingdom, and Los Alamos National Laboratory (LANL). The goal of this experiment was to measure neutron activation and thermoluminescent dosimeter (TLD) doses from a source similar to a fissile solution critical excursion. The resulting benchmark can be used for validation of computer codes and nuclear data libraries as required when performing analysis of criticality accident alarm systems (CAASs). A secondary goal of this experiment was to qualitatively test performance of two CAAS detectors similar to those currently and formerly in use in some US DOE facilities. The detectors tested were the CIDAS MkX and the Rocky Flats NCD-91. The CIDAS detects gammas with a Geiger-Muller tube, and the Rocky Flats detects neutrons via charged particles produced in a thin 6LiF disc, depositing energy in a Si solid-state detector. These detectors were being evaluated to determine whether they would alarm, so they were not expected to generate benchmark quality data.

  20. Notas sobre escrofulariáceas de Colombia: I. - Nueva especie de Buchnera afin A B. Rubriflora Philcox

    Directory of Open Access Journals (Sweden)

    Fernández Soto José Luis

    1986-12-01

    Full Text Available Se describe una nueva especie de Buchnera que presenta pilosidad glandular, la única entre las especies americanas del género y próxima a  B. rubriflora Philcox. Se aportan nuevos datos sobre la distribución y variabilidad de esta última, comentando finalmente la relación entre ambos táxones.  Al revisar las escrofulariáceas del Herbario Nacional Colombiano (COL, se tuvo la oportunidad de estudiar una serie de colecciones del género Buchnera, que son el objeto de esta primera nota sobre escrofulariáceas colombianas. Aparte de la localización de nuevos registros de B. rubriflora, que amplían la distribución conocida de la especie y otras puntualizaciones relativas a su parentesco y ecología; sin duda el dato más interesante lo aportó el estudio de unas plantas procedentes del sur de la Sierra de La Macarena (Depto. del Meta, que presentan indumento glandular, mezclado con pilosidad más corta no glandular. Este carácter único conocido hasta ahora en las buchneras americanas, permite describir esta planta como nueva. Este nuevo taxon está morfológicamente relacionado con B. rubriflora, con la que comparte además y con carácter exclusivo en las especies americanas la coloración roja de sus corolas. Se hacen por último algunos comentarios sobre este pequeño grupo de buchneras, del que probablemente falte aún mucho por conocer en cuanto a distribución y diversidad, por la falta de muestreo en amplios territorios colombianos ecológica y geológicamente similares a los enclaves hasta ahora conocidos para estos táxones.

  1. Free cancer cell detection in peritoneal cavity in gastric cancer patients by RT-PCR for CEA

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jong Inn; Moon, Nan Mo; Paik, Nam Sun; Choi, Dong Wook; Bang, Ho Yun; Hong, Seok Il [Korea Cancer Center Hospital, Seoul (Korea, Republic of)

    1997-12-01

    Authors applied RT-PCR assay to detecting CEA expressing free cancer cells in peritoneal cavity of 114 gastric cancer patients to find an indication for prophylactic treatment to prevent peritoneal recurrence. Sixty-three of 114 cases were positive for RT-PCR, of which 16 cases were positive for cytologic examination and 47 cases were negative. Forty-nine of 51 cases who were negative for RT-PCR were negative for cytologic examination. Positivity for RT-PCR according to the depth of invasion were as follows : two (28.6 %) of seven cases whose cancer invaded mucosal or submucosal layer were positive. Ten (45.5 %) of 22 cases whose cancer invaded muscular or subserosal layer were positive. Forty-one (57.7 %) of 71 serosa involved cases were positive. Eleven (78.6 %) of cases who had grossly perioneal seedings were positive (p=0.026). However, all of 7 EGC cases, 19 of 22 cases whose cancer invaded to muscle layer or to subserosa were negative for cytologic examination, and eight of 13 cases who had had peritoneal seedings were positive. Positivity for RT-PCR according to cell differentiation were as follows: forty-two (61.8 %) of 68 cases who cancer were poorly differentiated type were positive. (p=0.163) Serum level of CEA of RT-PCR positive group and that of negative group were not statistically different. It was revealed that RT-PCR was more sensitive than cytologic examination in detecting free tumor cells, especially in pm, ss and serosa positive cancers, so if further study with more cases and longer follow-up is performed, its role as prognostic factor and an indication of prophylactic therapy will be clarified. (author). 22 refs., 5 tabs.

  2. Las loganiáceas (Loganiaceæ de Cuba

    Directory of Open Access Journals (Sweden)

    Fernández Casas, F. J.

    1998-12-01

    Full Text Available Monographic revisión of the Loganiíaceæ of Cuba. It includes five genera, eight native species (two endemics and four introduced ones. For each species. after the nomenclature, description, hábitat and distribution, sorne data about dispersion and phenology are recorded, and sometimes ethnobotanical and chemical composition data. When found, karyologic information was a150 included. The chorological data are completed with eight maps showing the Cuban distribution of as many wild taxa. Further more, nine plates representing as many species are included, plus five indices. The first index shows the distributional maps. The second one shows the illustrations. The third one shows the 411 collections. The fourth one shows the common names. The fifth, which has 77 entries, shows all scientific names used, both the accepted ones and the synonyms.

    [es] Revisión monográfica de las loganiáceas de la flora de Cuba. Comprende cinco géneros con ocho especies endémicas (dos endemismos, más cuatro especies exóticas. Para cada especie y tras la nomenclatura, además de la descripción, el hábitat y la distribución, se consignan diversos datos sobre dispersión y fenología, más algunos etnobotánicos o de composición química ocasionalmente. Cuando pudimos hallarla, incl uimos información cariológica. Los datos corológicos se completan con ocho mapas que muestran la distribución cubana de otros tantos táxones nativos de Cuba. Acompañan al texto nueve láminas que representan otras tantas especies, más cinco índices, En el primero se encuentran los ocho mapas distribucionales. En el segundo las nueve ilustraciones. El tercero las 411 colecciones. En el cuarto los nombres vulgares. En el quinto figuran los 77 nombres científicos empleados, tanto aceptados como sinónimos, o confusiones. Un apéndice final, con cinco fotografías, reúne información diversa sobre tipos nomenclaturales. [ru] Моног

  3. Concordance of Hypermethylated DNA and the Tumor Markers CA 15-3, CEA, and TPA in Serum during Monitoring of Patients with Advanced Breast Cancer

    DEFF Research Database (Denmark)

    Kristiansen, Søren; Jørgensen, Lars Mønster; Høgh Hansen, Morten

    2015-01-01

    The serological protein tumor markers CA 15-3, CEA, and TPA are frequently used to monitor tumor burden among metastatic breast cancer patients. Breast cancer is associated with global DNA hypomethylation and hypermethylation of some promoter regions. No monitoring study has yet investigated the ...

  4. Achado incidental de glândula sebácea em colo uterino: provavelmente um processo metaplásico

    OpenAIRE

    Ogata,Daniel Cury; Pereira Neto,Elisiário; Perin, Daiana Paola; May, Bruna Miers

    2012-01-01

    As glândulas sebáceas ectópicas são achados muito infrequentes no trato genital feminino. Descrevemos um caso que ocorreu em paciente de 42 anos de idade, submetida à histerectomia total, devido à leiomiomatose e ao prolapso uterino.

  5. High Plasma TIMP-1 and Serum CEA Levels during Combination Chemotherapy for Metastatic Colorectal Cancer Are Significantly Associated with Poor Outcome

    DEFF Research Database (Denmark)

    Aldulaymi, Bahir; Byström, Per; Berglund, Ake

    2010-01-01

    Objective: To evaluate whether combination chemotherapy leads to early changes in plasma TIMP-1 and serum carcinoembryonic antigen (CEA) levels in patients with metastatic colorectal cancer (mCRC), and whether such changes relate to subsequent objective response, time to progression (TTP) and ove...

  6. The diagnostic value of serum tumor markers CEA, CA19-9, CA125, CA15-3, and TPS in metastatic breast cancer.

    Science.gov (United States)

    Wang, Weigang; Xu, Xiaoqin; Tian, Baoguo; Wang, Yan; Du, Lili; Sun, Ting; Shi, Yanchun; Zhao, Xianwen; Jing, Jiexian

    2017-07-01

    This study aims to understand the diagnostic value of serum tumor markers carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9), cancer antigen 125 (CA125), cancer antigen 15-3 (CA15-3), and tissue polypeptide-specific antigen (TPS) in metastatic breast cancer (MBC). A total of 164 metastatic breast cancer patients in Shanxi Cancer Hospital were recruited between February 2016 and July 2016. 200 breast cancer patients without metastasis in the same period were randomly selected as the control group. The general characteristics, immunohistochemical, and pathological results were investigated between the two groups, and tumor markers were determined. There were statistical differences in the concentration and the positive rates of CEA, CA19-9, CA125, CA15-3, and TPS between the MBC and control group (Pspecificity was in CA125 for the diagnosis of MBC when using a single tumor marker at 56.7% and 97.0%, respectively. In addition, two tumor markers were used for the diagnosis of MBC and the CEA and TPS combination had the highest diagnostic sensitivity with 78.7%, while the CA15-3 and CA125 combination had the highest specificity of 91.5%. Analysis of tumor markers of 164 MBC found that there were statistical differences in the positive rates of CEA and CA15-3 between bone metastases and other metastases (χ 2 =6.00, P=0.014; χ 2 =7.32, P=0.007, respectively). The sensitivity and specificity values of the CEA and CA15-3 combination in the diagnosis of bone metastases were 77.1% and 45.8%, respectively. The positive rate of TPS in the lung metastases group was lower than in other metastases (χ 2 =8.06, P=0.005).There were significant differences in the positive rates of CA15-3 and TPS between liver metastases and other metastases (χ 2 =15.42, Pspecificity of the CA15-3 and TPS combination in the diagnosis of liver metastases were 92.3% and 45.6%, respectively, and the positive rate of CEA in triple-negative metastatic breast cancer is lower than in other

  7. Clinical Significance and Prognostic Value of CA72-4 Compared with CEA and CA19-9 in Patients with Gastric Cancer

    Directory of Open Access Journals (Sweden)

    M. Ychou

    2000-01-01

    Full Text Available Carcinoembryonic antigen (CEA and CA 19-9 are both widely used in the follow up of patients with gastrointestinal cancer. More recently another tumor marker, named CA 72-4 has been identified and characterized using two different monoclonal antibodies B72.3 and CC49. Several reports evaluated CA 72-4 as a serum tumor marker for gastric cancer and compared its clinical utility with that of CEA or CA 19-9; few reports concerned its prognostic value. In the present study, CA 72-4 is evaluated and compared with CEA and CA 19-9 in various populations of patients with gastric cancer and benign disease; for 52 patients with gastric adenocarcinoma and 57 patients without neoplastic disease CEA, CA 19-9 and CA 72-4 were evaluated before treatment. Sensitivity of the tumor markers CA 72-4, CA 19-9 and CEA at the recommended cut-off level in all 52 patients were 58%, 50% the sensitivity increased to 75%. of these markers, for non metastatic patients, multivariate analyses indicated that none of the markers were significant, when adjusted for gender and age (which were indicators of poor prognosis; patients with abnormal values of CA72-4 tended to have shorter survival than patients with normal values (p < 0.07. In the metastatic population, only high values of CA19-9 (p < 0.02 and gender (women (p < 0.03 were indicators of poor prognosis in univariate analysis; multivariate analysis revealed that both CA72-4 (p = 0.034 and CA19-9 p = 0.009, adjusted for gender were independent prognostic factors. However, CA72-4 lost significance (p = 0.41 when adjusted for CA19-9 and gender, indicating that CA19-9 provides more prognostic information than CA72-4.

  8. Digitization and valorization through the INIS database of an exceptional stock of grey literature documents: the 'historical' CEA reports (1948-1969); Numerisation et valorisation au travers de la base INIS d'un fonds documentaires exceptionnel de litterature grise: les rapports 'historiques' du CEA (1948-1969)

    Energy Technology Data Exchange (ETDEWEB)

    Surmont, J.; Brulet, C.; Brulet, M.; Pourny, M.; Constant, A.; Guille, N.; Le Blanc, A.; Mouffron, O.; Anguise, P.; Jouve, J.J

    2008-07-01

    This poster, prepared for the sixth edition of the meetings of scientific and technical information professionals (RPIST, Nancy (France)), presents the joint CEA/IAEA project of digitization of the collection of reports published by the French atomic energy commission (CEA) between 1948 and 1969. This exceptional stock of about 2760 grey literature monographs covers the first 20 years of researches carried out at the CEA and has been entered in the INIS database with a link to the full text. The poster describes the different steps of the project from the selection of the documents, their digitization, and the preparation of the corresponding inputs. The INIS database and its general content are briefly presented. (J.S.)

  9. PATRONES DE DISTRIBUCIÓN DE LAS COMUNIDADES DE CACTÁCEAS EN LAS VERTIENTES OCCIDENTALES DE LOS ANDES PERUANOS

    Directory of Open Access Journals (Sweden)

    Galán de Mera Antonio

    2012-12-01

    Full Text Available El presente trabajo trata de establecer una relación entre las comunidades deCactáceas y su distribución en las vertientes occidentales de los Andes del Perú. Paraello empleamos distintos valores climáticos de precipitación y evapotranspiraciónpotencial, y los índices climáticos de termicidad y aridez. Sobre una matriz con lacomposición florística de las comunidades aplicamos el índice de Sørensen obteniendoun dendrograma que explica cómo se agrupan las comunidades según provinciasbiogeográficas y pisos bioclimáticos. Aplicando sobre las distintas localidadesseleccionadas un Análisis de Componentes Principales (ACP podemos deducir cómose agrupan en función de la altitud y los valores e índices climáticos. Las poblacionesde Cactáceas situadas al norte del paralelo 8°Sur son las más influidas por la humedadaportada por la corriente de El Niño; bajo el paralelo 8°Sur, las localidades situadasen las vertientes occidentales andinas dependen de la escasa humedad estival (HE,aunque en el sur también puede ser evidente la invernal (HI al recibir las lluvias dedepresiones aisladas que se desprenden de borrascas sub-antárticas entre julio y agosto;no obstante, los andenes de cultivo ancestrales reflejan un clima más húmedo queel actual. En la costa y áreas basales próximas al desierto abiótico, la aridez es muyelevada aunque aún están presentes las comunidades con Neoraimondia arequipensis. Las comunidades situadas al norte del paralelo 8° Sur pertenecen a la provinciabiogeográfica Pacífica, las del centro a la provincia Ancashino-Paceña, las de losdepartamentos de Arequipa, Moquegua y Tacna, a la provincia Oruro-Arequipeña, ylas del Desierto Pacífico a la provincia Limeño-Ariqueña

  10. Efeito da cobertura viva com leguminosas herbáceas perenes na agregação de um argissolo

    Directory of Open Access Journals (Sweden)

    A. Perin

    2002-09-01

    Full Text Available O presente trabalho foi desenvolvido na área do Campo Experimental da Embrapa Agrobiologia, Seropédica (RJ, com o objetivo de avaliar a morfologia e a distribuição de raízes de algumas leguminosas herbáceas perenes; os efeitos da cobertura viva no teor de carbono orgânico, e a agregação de um Argissolo Vermelho-Amarelo distrófico, medida pela estabilidade dos agregados em água. O delineamento experimental adotado foi o de blocos casualizados, com três repetições. Os tratamentos consistiram de três diferentes espécies de leguminosas herbáceas perenes e um tratamento-controle sem cobertura viva (capinado. As leguminosas utilizadas foram amendoim forrageiro (Arachis pintoi, cudzu tropical(Pueraria phaseoloides e siratro (Macroptilium Atropurpureum. Para a estabilidade de agregados, as profundidades de amostragem foram 0-5 e 5-10 cm, enquanto, para a morfologia e distribuição radicular, as avaliações consistiram das profundidades 0-5, 5-10, 10-20 e 20-40 cm. As coberturas com as leguminosas amendoim forrageiro e cudzu tropical propiciaram os maiores valores percentuais na classe de agregados > 2,00 mm, em média 38 % superiores aos obtidos na área capinada. Os valores do diâmetro médio ponderado (DMP dos agregados no solo com cobertura de leguminosas foram superiores aos da área capinada para ambas as camadas, o que demonstra o efeito favorável das coberturas vivas na estabilização dos agregados do solo. A cobertura viva de amendoim forrageiro proporcionou incremento no teor de carbono orgânico no solo. Quanto aos atributos morfológicos das raízes, verificou-se que o amendoim forrageiro apresentou raio radicular intermediário entre as demais espécies e área e massa radicular maiores, o que auxiliou na interpretação do efeito positivo da cobertura viva com essa espécie na agregação do solo.

  11. ASN inspection of waste processing facilities operated by the CEA in the Ile-de-France region; Le controle par l'ASN des installations de traitement des dechets exploitees par le CEA en Ile-de-France

    Energy Technology Data Exchange (ETDEWEB)

    Baraer, B. [Autorite de Surete Nucleaire, inspecteur de la surete nucleaire a la Division d' Orleans, 75 - Paris (France)

    2011-02-15

    ASN (French Nuclear Safety Authority) ensures that safety at nuclear radioactive waste processing and storage facilities is maintained at an acceptable level and, where this is not the case, requires that facilities be brought up to standard. The specific characteristic of such facilities, which are often old, have to satisfy demand for reprocessing the waste currently produced by nuclear facilities and also meet the need to manage old waste storage facilities that were designed to comply with standards that are now out-of-date. This has led the operator first to set up new, higher performance facilities or workshops and, second, to carry out works on these old waste storage sites or transfer this waste to more suitable facilities. All these various projects result in major changes being made to these facilities. Based on the information supplied by the operator, ASN ensures that the safety analysis is satisfactory and, by means of spot checks, verifies that operations are conducted in compliance with procedures resulting from this analysis. In addition, INB (nuclear facilities) operating activities are often out-sourced. ASN checks that the implementation of such activities and monitoring of the subcontractor by the operator meet the applicable regulatory requirements. The examples of the waste processing INBs at the CEA sites at Fontenay-aux-Roses and Saclay perfectly illustrate the above. (author)

  12. Caracterização físico-química de algumas tuberosas amiláceas

    Directory of Open Access Journals (Sweden)

    Leonel Magali

    2002-01-01

    Full Text Available As principais fontes de amido comercial no mundo são o milho, a batata e a mandioca. Entretanto, nos últimos anos vem crescendo o interesse em amidos naturais que possam ser utilizados pela indústria alimentícia. Assim, este trabalho teve por objetivo caracterizar, quanto à composição físico-química, açafrão, ahipa, araruta, batata-doce, biri, inhame e mandioquinha-salsa, tuberosas amiláceas potencialmente passíveis de introdução como matérias-primas de interesse comercial. Amostras das tuberosas foram analisadas quanto ao teor de umidade, cinzas, proteína, matéria graxa, açúcares redutores e totais, fibras e amido. Os resultados obtidos mostraram que das tuberosas analisadas as que apresentaram maior teor de amido foram a araruta (Maranta arundinacea, o inhame (Dioscorea sp e o biri (Canna edulis, sendo que o inhame e o biri apresentaram também o maior rendimento potencial em toneladas de amido/hectare.

  13. Review of nuclear data improvement needs for nuclear radiation measurement techniques used at the CEA experimental reactor facilities

    Directory of Open Access Journals (Sweden)

    Destouches Christophe

    2016-01-01

    Full Text Available The constant improvement of the neutron and gamma calculation codes used in experimental nuclear reactors goes hand in hand with that of the associated nuclear data libraries. The validation of these calculation schemes always requires the confrontation with integral experiments performed in experimental reactors to be completed. Nuclear data of interest, straight as cross sections, or elaborated ones such as reactivity, are always derived from a reaction rate measurement which is the only measurable parameter in a nuclear sensor. So, in order to derive physical parameters from the electric signal of the sensor, one needs specific nuclear data libraries. This paper presents successively the main features of the measurement techniques used in the CEA experimental reactor facilities for the on-line and offline neutron/gamma flux characterizations: reactor dosimetry, neutron flux measurements with miniature fission chambers and Self Power Neutron Detector (SPND and gamma flux measurements with chamber ionization and TLD. For each technique, the nuclear data necessary for their interpretation will be presented, the main identified needs for improvement identified and an analysis of their impact on the quality of the measurement. Finally, a synthesis of the study will be done.

  14. Development and manufacturing of a Nb$_{3}$Sn quadrupole magnet Model at CEA/Saclay for TESLA Interaction Region

    CERN Document Server

    Durante, Maria; Fratini, M; Leboeuf, D; Segreti, M; Védrine, Pierre; 10.1109/TASC.2004.829129

    2004-01-01

    One possible application of Nb/sub 3/Sn, whose superconducting properties far exceed those of NbTi, is the fabrication of short and powerful quadrupole magnets for the interaction regions of large particle accelerators. In some projects, as in the future linear collider TESLA, the quadrupole magnets are inside the detector solenoid and must operate in its background field. This situation gives singular Lorentz force distribution in the ends of the magnet. To learn about Nb/sub 3/Sn technology, evaluate fabrication techniques and test the interaction with a solenoidal field, DAPNIA /SACM at CEA/Saclay has started the manufacturing of a 1-m-long, 56- mm-single-aperture quadrupole magnet model. The model relies on the same coil geometry as the LHC arc quadrupole magnets, but has no iron yoke. It will produce a nominal field gradient of 211 T/m at 11,870 A. The coils are wound from Rutherford-type cables insulated with glass fiber tape, before being heat-treated and vacuum-impregnated with epoxy resin. Laminated,...

  15. Reserva de carbono en un sistema silvopastoril compuesto de Pinus patula y herbáceas nativas

    Directory of Open Access Journals (Sweden)

    Manuel Oliva

    2017-01-01

    Full Text Available La investigación tuvo como objetivo determinar la reserva de carbono retenida bajo un sistema silvopastoril con Pinus patula , localizado en Amazonas, Perú. Para la estimación de carbono se utilizaron 06 plantas mediante el método directo, los fustes fueron seccionados cada 2 metros y a partir de estos se obtuvieron muestras de 5 cm de espesor previo al pesaje total. Para las ramas y hojas se realizó el pesaje total y se seleccionaron muestras de 200 g. Para la recolección de muestras de hojarasca y herbáceas nativas, se utilizó el mé todo del cuadrante y las muestras de suelo se recolectaron alrededor de cada planta. Los datos fueron obtenidos mediante la formulación de ecuaciones alométricas y selección de la mayor correlación estimada, a partir de variables como diámetro a la altura del pecho (DAP y altura del fuste (AF. Como resultado, se encontró 92,13 t/ha de carbono almacenado y 337,20 t/ha de carbono equivalente. Además, la investigación permitió establecer una ecuación que ayudó a estimar la cantidad de carbono y CO 2 en pino p átula: Biomasa seca = 0,6575*DAP 1,1794 (r 2 = 0,91 .

  16. Principais doenças de Anonáceas no Brasil: descrição e controle

    Directory of Open Access Journals (Sweden)

    Nilton Tadeu Vilela Junqueira

    2014-01-01

    Full Text Available Várias doenças podem afetar folhas, caules, flores e frutos de gravioleira, pinheira e atemoia em diferentes estádios de seus desenvolvimentos. Geralmente, as doenças mais importantes são causadas por fungos durante o florescimento e a frutificação. Também podem ocorrer murchas ou podridões de raízes, causadas por nematoides e patógenos do solo. A antracnose (Colletotrichum gloeosporioides, murcha ou podridões de raízes (Rhizoctonia solani, Cylindrocladium clavatum, Phytophthora sp., Pythium sp., Phytophthora nicotianae var. parasitica, cancros (Albonectria rigidiuscula e podridão de frutos (Botryodiplodia theobromae, sin. Lasiodiplodia theobromae são as mais importantes. Por outro lado, a podridão-parda-do-fruto (Rhizopus stolonifer provoca perdas expressivas na produção de graviola. A seguir, são descritas as principais doenças que afetam estas espécies de anonáceas, seus agentes causais e as medidas de controle.

  17. Diatomáceas do paleógeno do platô de São Paulo (dsdp leg 39, site 356)

    OpenAIRE

    Paier, Carina

    2011-01-01

    Diatomáceas são excelentes marcadores bioestratigráficos para as Eras Meso-Cenozóicas e são elementos bastante úteis para estudos paleoecológicos e paleoceanográficos. O presente trabalho consiste no estudo das diatomáceas do intervalo Paleógeno do Poço 356 (DSDP Leg 39), o qual foi perfurado na encosta oeste do Alto de São Paulo (margem sudoeste do Platô de São Paulo). As rochas deste local pertencem à porção distal da Bacia de Santos e as rochas deste intervalo Paleógeno pertencem à Formaçã...

  18. Serum tetranectin is an independent prognostic marker in colorectal cancer and weakly correlated with plasma suPAR, plasma PAI-1 and serum CEA

    DEFF Research Database (Denmark)

    Høgdall, Claus K; Christensen, Ib J; Stephens, Ross W

    2002-01-01

    PAR and CEA had a 2.43 increased risk as compared to a patient with median levels of these biochemical markers. Significant correlations were found with Dukes' stages for all the biochemical markers and between the respective biochemical markers. The findings confirm that TN is a strong prognostic factor...... in patients with colorectal cancer. TN may be valuable as a prognostic variable in future studies evaluating new treatment strategies for colorectal cancer....

  19. Radioimmunoscintigraphy using {sup 99m}Tc-anti-CEA F(ab's){sub 2} fragment in rectal cancer and a pilot study for radioimmunoguided surgery

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Jin Sook; Kim, Jin Choen; Kim, Chang Nam; Gong, Gyung Yub; Lee, Hee Kyung [Ulsan Univ. College of Medicine, Seoul (Korea, Republic of)

    2000-06-01

    This prospective study was performed to evaluate the usefulness of preoperative radioimmunoscintigraphy and intraoperative scintimetric examination (radioimmunoguided surger: RIGS) using{sup 99m}Tc-anti-CEA F(ab'){sub 2} fragment. Nineteen patients with rectal cancer underwent preoperative whole body planar scintigraphy at 4 hours after injection of {sup 99m}Tc-anti-CEA F(ab'){sub 2} fragment and SPECT imaging at 18 hours. Surgical operation was performed at 24 hours after injection. During laparotomy, radioactivities from intraabdominal viscera were measured by gamma probe. The radioactivities from excised tumor and lymph nodes were also measured and compared with pathology. All nineteen patients were confirmed to have adenocarcinomas in the rectum. Twenty-seven of 97 excised lymph node groups had metastasis and 2 patients had liver metastasis in pathology. Preoperative radioimmunoscintigraphy detected primary tumors in 11 patients (sensitivity 55%) and it could not detect any lymph nodes or liver metastasis. All patients showed high radioactivity in the kidneys, liver, spleen, and major vessels in intraoperative measurement by gamma probe, and tumor activity was not discriminated from background activity. However, radioactivity from excised tumor was higher than normal rectum (T/B ratio; 3,47{+-}2.25). When excised lymph node activity/background activity ratio >1.5 was considered as positive criteria of metastasis, sensitivity, specificity, positive and negative predictive values were 78.6%, 73.9%, 55.0% and 89.5%, respectively. Radioimmunoscintigraphy using {sup 99m}Tc-anti-CEA F(ab'){sub 2} has no additional value for preoperative staging and use of early RIGS using {sup 99m}Tc-anti-CEA F(ab'){sub 2} is inappropriate. For early RIGS using {sup 99m}Tc labeled antibodies in rectal cancer patients, further development of more specific antibodies and methods to reduce background activity are needed.

  20. The role of two enzymes (LDH and PHI) and a tumour marker (CEA) in the prognostic evalution of head and neck malignancy.

    Science.gov (United States)

    Narang, A P; Greval, R S; Chopra, H; Kalra, C S

    2001-01-01

    A study of 30 patients with biopsy proven carcinoma of head and neck were taken and serum levels of CEA, LDH and PHI was estimated before treatment and 3 months post treatment. 30 patients were taken as controls for comparison. Pre- and past-treatment levels were statistically compared and the role of surgery, radiotherapy and chemotherapy compared. Variation with metastasis and with smoking was also evaluated.

  1. Serum TK1 is a more reliable marker than CEA and AFP for cancer screening in a study of 56,286 people.

    Science.gov (United States)

    Wang, Yu; Jiang, Xiaorong; Dong, Shaoliang; Shen, Jiankun; Yu, Haixia; Zhou, Ji; Li, Jin; Ma, Hongbo; He, Ellen; Skog, Sven

    2016-03-11

    The World Health Organization (WHO) has estimated that the number of cancer patients will increase by about 70% during the next 25 years world-wide. To deal with this problem, WHO has suggested a focus on prevention of tumor incidence and health screening for early detection of people with tumors. To investigate the use of thymidine kinase 1 (TK1), CEA and AFP in serum to discover people with malignant tumors through health cancer screening. Of a cohort in 486,085 people of a routine health screening at the Health Centre, Fujun 180 Hospital, Quanzhou city, China, 56,286 people were investigated according to the presence of cancer during 2009-2014. The concentration of CEA and AFP were determined by an electrochemiluminescence immunoassay from Roche Diagnostics e601GmbH and STK1 by a commercial kit based on an enhanced chemiluminescent dot blot assay. The cancer incident rate increased from 0.048/100,000 to 0.220/100,000. The most common types of tumors were those of the liver, cervix and lung. STK1 correlated to tumor growth rate, was more sensitive than CEA and AFP for discovering people with malignant tumors and more sensitive among people who had diagnosis of malignant tumor. STK1 was also a prognostic biomarker for death at 10-40 months follow-up, while CEA and AFP were not. A combination of these markers increased the sensitivity by about 30%. STK1 is a reliable biomarker for discovering people with malignant tumors in cancer screening.

  2. Significance of the evaluation of the tissue proliferation specific marker (TPS) and the carcinoembryonal antigen (CEA) in patients with ulcerative colitis and adenocarcinoma.

    Science.gov (United States)

    Krauss, Hanna; Ignyś, Iwona; Kopczyński, Zygmunt; Piatek, Jacek

    2002-01-01

    The aim of our research was to evaluate TPS concentration as a marker of proliferative processes and the levels of CEA in children and adults with ulcerative colitis (UC) and in adults with colorectal adenocarcinoma (AC), to find out if there is any interdependence between TPS and CEA concentrations in these patients and to evaluate the usefulness of TPS as a marker of neoplastic risk in patients with UC. The study was carried out in 3 groups of patients: Group I consisted of 15 children, ages 10-18, treated for UC; Group II, 22 adults, ages 23-40, treated for UC; and Group III, 14 patients, ages 40-60, in whom AC was diagnosed. In Group II, the mean TPS concentration was significantly higher than in Group I (pGroup III, adults with AC, the mean TPS concentration was 1074.00+/-1356.87 U/l. Thus there was a statistically significant difference between TPS concentrations in adults with UC and adults with AC (pgroups with UC. However, a statistically significant difference occurred between CEA concentrations in children and adults with UC and the group of adults with AC (peffectiveness.

  3. Rooting of herbaceous minicuttings of passion fruit/ Enraizamento de miniestacas herbáceas de maracujazeiro amarelo

    Directory of Open Access Journals (Sweden)

    Rudival Faquim

    2007-08-01

    Full Text Available The objective of this work was to evaluate the effect of the basal cut, leaf presence and the treament with a root suspension in the rooting of herbaceous minicuttings of yellow passion fruit. The experiment was realized in a greenhouse using minicuttings with 8 cm of lenght and two nodes, collected from yellow passion fruit seedlings. The longitudinal basal cut in the minicuttings was done until the basal node. The leaves were removed or a half of a single leaf was maintained in the apical node. The minicuttings were treated with a root suspension in water in three concentrations (0, 100 e 200 g L-1. After 58 days, the rooting percentage, the number of roots and the root dry matter produced per minicutting were determined. The entirely randomized experimental design was used in a factorial esqueme (2 x 2 x 3 with three replications. The propagation of the yellow passion fruit by herbaceous minicuttings was viable and the presence of the half of a single leaf in the apical node give a higher production of number and dry matter of roots. The basal cut was only a little favourable to the production of roots and the treatment with a root suspension did not present a benefit to the plant propagation.Este trabalho objetivou avaliar a influência do corte basal, da presença da folha e do tratamento com suspensão de raízes no enraizamento de miniestacas herbáceas de maracujazeiro amarelo. O experimento foi conduzido em casa de vegetação com miniestacas de 8 cm de comprimento e dois nós, obtidas de mudas de maracujazeiro. O corte longitudinal na base das estacas foi feito até o nó basal. Foram retiradas as folhas ou mantida a metade da folha do nó apical. As miniestacas foram tratadas com suspensão de raízes mais água nas concentrações de 0, 100 e 200 g L-1. Após 58 dias, determinou-se a porcentagem de estacas enraizadas, o número de raízes emitidas e a massa seca de raízes por estaca. O delineamento experimental utilizado foi o

  4. Detección temprana de resistencia a Mycosphaerella fijiensis en genotipos locales de Musáceas en Ecuador

    Directory of Open Access Journals (Sweden)

    Galo Cedeño García

    2017-01-01

    Full Text Available El objetivo de la investigación fue determinar la reacción de 14 genotipos de musáceas frente a Mycosphaerella fijensis, agente causal de la Sigatoka negra. Se condujeron dos experimentos en el Departamento de Protección Vegetal de la Estación Experimental P ichilingue del Instituto Nacional de Investigaciones Agropecuarias (INIAP, Ecuador. Los genotipos evaluados fueron: banano Orito (AA, Guineo de jardín, Williams, Filipino, Gros Michel, Mulato y Morado, del genoma (AAA, y los plátanos Limeño, Maqueño, Do minico, Dominico - Hartón, Dominico gigante, Dominico negro y Barraganete, del genoma AAB. Se usaron dos métodos de inoculación: a in vitro sobre fragmentos de hoja con una suspensión de conidios y b inoculación de pl á ntulas de ocho semanas de edad con una suspensión micelial. En el primer caso se midió el periodo de incubación (PI y el número de lesiones a los 14 y 20 días después de la inoculación (DDI. En invernadero, se registró el PI, tiempo de evolución de síntomas (TES y tiempo de desarrollo de la enfermedad (TDE. Se determinaron diferencias estadísticas significativas (p ≤ 0 , 05 para todas las variables evaluadas; los cultivares Orito (AA y Limeño (AAB calificaron como resistentes, mientras que todos los demás fueron susceptibles, aunque mostra ron un rango de variabilidad en la respuesta a las inoculaciones .

  5. New trends in {gamma}-ray imaging with CdZnTe/CdTe at CEA-Leti

    Energy Technology Data Exchange (ETDEWEB)

    Verger, Loick [LETI-CEA-MINATEC Recherche Technologique, CEA Grenoble, 17 rue des Martyrs, F 38054 Grenoble, Cedex 9 (France)]. E-mail: loick.verger@cea.fr; Gros d' Aillon, Eric [LETI-CEA-MINATEC Recherche Technologique, CEA Grenoble, 17 rue des Martyrs, F 38054 Grenoble, Cedex 9 (France); Monnet, Olivier [LETI-CEA-MINATEC Recherche Technologique, CEA Grenoble, 17 rue des Martyrs, F 38054 Grenoble, Cedex 9 (France); Montemont, Guillaume [LETI-CEA-MINATEC Recherche Technologique, CEA Grenoble, 17 rue des Martyrs, F 38054 Grenoble, Cedex 9 (France); Pelliciari, Bernard [LETI-CEA-MINATEC Recherche Technologique, CEA Grenoble, 17 rue des Martyrs, F 38054 Grenoble, Cedex 9 (France)

    2007-02-01

    Increasing interest in CdTe/CZT for {gamma}-ray imaging has marked the last 10 years with progress in crystal growth, device technology, integrated electronics and signal processing. The purpose of this paper is to present recent advances in these four fields at CEA-LETI. A new method to grow very large dimension CZT up to 300 mm in diameter is presented. MS-contact process control allows design of very small electrodes (100 {mu}m pitch) and results on long-term stability are presented. The development of low-noise front-end integrated electronics and new interconnects technologies have made 'pixel detectors' feasible. Significant effort has been focused on reaching high-energy resolution as well as high detection efficiency. The combination of signal processing such as bi-parametric (BP) approaches and electrode design presents an interest in charge loss compensation for a large range of {mu}{tau} products, tailing reduction due to geometric effect and depth of interaction information. New digital approaches may give drastic advantages to push the limit of spectrometric performance. In the field of {gamma}-ray application, single-channel device for per-operative probes and small 2-D imager for molecular imaging are the most promising ones. By using a tailored 'mixed' electrode (small anode and capacitive grid Frich effect) and a BP correction, an energy resolution of 1% at 662 keV has been demonstrated with CZT based 8x8x15 mm{sup 3} detector. New results of 3-D CZT detectors for {mu}PET imaging are presented with a measured coincidence time of 2.6 ns FWHM and an expected spatial resolution of 1 mm FWHM.

  6. Artrite da gota tofácea crônica mimetizando artrite reumatoide Chronic tophaceous gout mimicking rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Juliana F. Sarmento

    2009-12-01

    Full Text Available A gota é um distúrbio no metabolismo das purinas, usualmente associado à ocorrência de crises recorrentes de artrite nas articulações dos membros inferiores em homens entre 40-50 anos, e com o desenvolvimento de tofos subcutâneos nos pacientes com doença de longa evolução. Casos de pacientes com artrite gotosa crônica que mimetizam quadros de artrite reumatoide e vice-versa são raros. Descrevemos o caso de um paciente de 56 anos, com quadro de artrite poliarticular, simétrica e deformante, comprometendo principalmente as articulações de mãos e punhos, com nódulos subcutâneos difusos pelo corpo, alterações radiográficas atípicas e urolitíase, que, após avaliação clínica e dos exames complementares, recebeu diagnóstico de gota tofácea crônica mutilante mimetizando artrite reumatoide.Gout is a disorder of purine metabolism, usually associated with recurrent bouts of arthritis in the joints of the lower limbs, affecting men 40 to 50 years of age, which leads to the development of subcutaneous tophi in patients with long-lasting disease. Cases of patients with chronic gouty arthritis mimicking rheumatoid arthritis, and vice-versa, are rare. This report describes the case of a 56-year old male with symmetric, deforming, and polyarticular arthritis affecting, specially, the joints of the hands and wrists, with diffuse subcutaneous nodules throughout his body, atypical radiographic findings, and urolithiasis. Following clinical evaluation and additional tests, this patient received a diagnosis of chronic tophaceous gout mimicking mutilating rheumatoid arthritis.

  7. CEA (Carcinoembryonic Antigen) Test

    Science.gov (United States)

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  8. CEA blood test

    Science.gov (United States)

    Carcinoembryonic antigen blood test ... A blood sample is needed . ... When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging sensation. Afterward, there may be some throbbing or a slight bruise. ...

  9. Multi-arm Cost-Effectiveness Analysis (CEA comparing different durations of adjuvant trastuzumab in early breast cancer, from the English NHS payer perspective.

    Directory of Open Access Journals (Sweden)

    Caroline S Clarke

    Full Text Available Trastuzumab improves survival in HER2+ breast cancer patients, with some evidence of adverse cardiac side effects. Current recommendations are to give adjuvant trastuzumab for one year or until recurrence, although trastuzumab treatment for only 9 or 10 weeks has shown similar survival rates to 12-month treatment. We present here a multi-arm joint analysis examining the relative cost-effectiveness of different durations of adjuvant trastuzumab.Network meta-analysis (NMA was used to examine which trials' data to include in the cost-effectiveness analysis (CEA. A network using FinHer (9 weeks vs. zero and BCIRG006 (12 months vs. zero trials offered the only jointly randomisable network so these trials were used in the CEA. The 3-arm CEA compared costs and quality-adjusted life-years (QALYs associated with zero, 9-week and 12-month adjuvant trastuzumab durations in early breast cancer, using a decision tree followed by a Markov model that extrapolated the results to a lifetime time horizon. Pairwise incremental cost-effectiveness ratios (ICERs were also calculated for each pair of regimens and used in budget impact analysis, and the Bucher method was used to check face validity of the findings. Addition of the PHARE trial (6 months vs. 12 months to the network, in order to create a 4-arm CEA including the 6-month regimen, was not possible as late randomisation in this trial resulted in recruitment of a different patient population as evidenced by the NMA findings. The CEA results suggest that 9 weeks' trastuzumab is cost-saving and leads to more QALYs than 12 months', i.e. the former dominates the latter. The cost-effectiveness acceptability frontier (CEAF favours zero trastuzumab at willingness-to-pay levels below £2,500/QALY and treatment for 9 weeks above this threshold. The combination of the NMA and Bucher investigations suggests that the 9-week duration is as efficacious as the 12-month duration for distant-disease-free survival and overall

  10. Multi-arm Cost-Effectiveness Analysis (CEA) comparing different durations of adjuvant trastuzumab in early breast cancer, from the English NHS payer perspective.

    Science.gov (United States)

    Clarke, Caroline S; Hunter, Rachael M; Shemilt, Ian; Serra-Sastre, Victoria

    2017-01-01

    Trastuzumab improves survival in HER2+ breast cancer patients, with some evidence of adverse cardiac side effects. Current recommendations are to give adjuvant trastuzumab for one year or until recurrence, although trastuzumab treatment for only 9 or 10 weeks has shown similar survival rates to 12-month treatment. We present here a multi-arm joint analysis examining the relative cost-effectiveness of different durations of adjuvant trastuzumab. Network meta-analysis (NMA) was used to examine which trials' data to include in the cost-effectiveness analysis (CEA). A network using FinHer (9 weeks vs. zero) and BCIRG006 (12 months vs. zero) trials offered the only jointly randomisable network so these trials were used in the CEA. The 3-arm CEA compared costs and quality-adjusted life-years (QALYs) associated with zero, 9-week and 12-month adjuvant trastuzumab durations in early breast cancer, using a decision tree followed by a Markov model that extrapolated the results to a lifetime time horizon. Pairwise incremental cost-effectiveness ratios (ICERs) were also calculated for each pair of regimens and used in budget impact analysis, and the Bucher method was used to check face validity of the findings. Addition of the PHARE trial (6 months vs. 12 months) to the network, in order to create a 4-arm CEA including the 6-month regimen, was not possible as late randomisation in this trial resulted in recruitment of a different patient population as evidenced by the NMA findings. The CEA results suggest that 9 weeks' trastuzumab is cost-saving and leads to more QALYs than 12 months', i.e. the former dominates the latter. The cost-effectiveness acceptability frontier (CEAF) favours zero trastuzumab at willingness-to-pay levels below £2,500/QALY and treatment for 9 weeks above this threshold. The combination of the NMA and Bucher investigations suggests that the 9-week duration is as efficacious as the 12-month duration for distant-disease-free survival and overall survival

  11. Near infra-red photoimmunotherapy with anti-CEA-IR700 results in extensive tumor lysis and a significant decrease in tumor burden in orthotopic mouse models of pancreatic cancer.

    Directory of Open Access Journals (Sweden)

    Ali A Maawy

    Full Text Available Photoimmunotherapy (PIT of cancer utilizes tumor-specific monoclonal antibodies conjugated to a photosensitizer phthalocyanine dye IR700 which becomes cytotoxic upon irradiation with near infrared light. In this study, we aimed to evaluate the efficacy of PIT on human pancreatic cancer cells in vitro and in vivo in an orthotopic nude mouse model. The binding capacity of anti-CEA antibody to BxPC-3 human pancreatic cancer cells was determined by FACS analysis. An in vitro cytotoxicity assay was used to determine cell death following treatment with PIT. For in vivo determination of PIT efficacy, nude mice were orthotopically implanted with BxPC-3 pancreatic tumors expressing green fluorescent protein (GFP. After tumor engraftment, the mice were divided into two groups: (1 treatment with anti-CEA-IR700 + 690 nm laser and (2 treatment with 690 nm laser only. Anti-CEA-IR700 (100 μg was administered to group (1 via tail vein injection 24 hours prior to therapy. Tumors were then surgically exposed and treated with phototherapy at an intensity of 150 mW/cm2 for 30 minutes. Whole body imaging was done subsequently for 5 weeks using an OV-100 small animal imaging system. Anti-CEA-IR700 antibody bound to the BxPC3 cells to a high degree as shown by FACS analysis. Anti-CEA-IR700 caused extensive cancer cell killing after light activation compared to control cells in cytotoxicity assays. In the orthotopic models of pancreatic cancer, the anti-CEA-IR700 group had significantly smaller tumors than the control after 5 weeks (p<0.001. There was no significant difference in the body weights of mice in the anti-CEA-IR700 and control groups indicating that PIT was well tolerated by the mice.

  12. CEA Level, Radical Surgery, CD56 and CgA Expression Are Prognostic Factors for Patients With Locoregional Gastrin-Independent GNET.

    Science.gov (United States)

    Li, Yuan; Bi, Xinyu; Zhao, Jianjun; Huang, Zhen; Zhou, Jianguo; Li, Zhiyu; Zhang, Yefan; Li, Muxing; Chen, Xiao; Hu, Xuhui; Chi, Yihebali; Zhao, Dongbing; Zhao, Hong; Cai, Jianqiang

    2016-05-01

    Gastrin-independent gastric neuroendocrine tumors (GNETs) are highly malignant. Radical resections and lymphadenectomy are considered to be the only possible curative treatment for these tumors. However, the prognosis of gastrin-independent GNETs is not well defined. In this study, we identified prognostic factors of locoregional gastrin-independent GNETs.All patients diagnosed with locoregional gastrin-independent GNETs between 2000 and 2014 were included in this retrospective study. Clinical characteristics, blood tests, pathological characteristics, treatments, and follow-up data of the patients were collected and analyzed.Of the 66 patients diagnosed with locoregional gastrin-independent GNETs, 57 (86.4%) received radical resections, 7 (10.6%) with palliative resection, 1 (1.5%) with gastrojejunostomy, and 1 (1.5%) with exploration surgeries. The median survival time for these patients was 19.0 months (interquartile range, 11.0-38.0). The 1-, 3-, and 5-year survival rates were 72%, 34%, and 28%, respectively. Multivariate analysis indicated that carcinoembryonic antigen (CEA) level (P = 0.04), radical resection (P = 0.04), and positive Cluster of Differentiation 56 (CD56) expression (P = 0.016) were significant prognostic factors on overall survival rate. Further univariate and multivariate analysis of 57 patients who received radical resections found that CgA expression (P = 0.35) and CEA level (P = 0.33) are independent prognostic factors.Gastrin-independent GNETs had poor prognosis. Serum CEA level, radical surgery, CD56 and CgA expression are markers to evaluate the survival of patients with locoregional gastrin-independent GNETs.

  13. Evaluation of the concrete shield compositions from the 2010 criticality accident alarm system benchmark experiments at the CEA Valduc SILENE facility

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Thomas Martin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Celik, Cihangir [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dunn, Michael E [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wagner, John C [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McMahan, Kimberly L [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Authier, Nicolas [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Jacquet, Xavier [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Rousseau, Guillaume [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Wolff, Herve [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Savanier, Laurence [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Baclet, Nathalie [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Lee, Yi-kang [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Trama, Jean-Christophe [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Masse, Veronique [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Gagnier, Emmanuel [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Naury, Sylvie [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Blanc-Tranchant, Patrick [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Hunter, Richard [Babcock International Group (United Kingdom); Kim, Soon [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dulik, George Michael [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Reynolds, Kevin H. [Y-12 National Security Complex, Oak Ridge, TN (United States)

    2015-01-01

    In October 2010, a series of benchmark experiments were conducted at the French Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA) Valduc SILENE facility. These experiments were a joint effort between the United States Department of Energy Nuclear Criticality Safety Program and the CEA. The purpose of these experiments was to create three benchmarks for the verification and validation of radiation transport codes and evaluated nuclear data used in the analysis of criticality accident alarm systems. This series of experiments consisted of three single-pulsed experiments with the SILENE reactor. For the first experiment, the reactor was bare (unshielded), whereas in the second and third experiments, it was shielded by lead and polyethylene, respectively. The polyethylene shield of the third experiment had a cadmium liner on its internal and external surfaces, which vertically was located near the fuel region of SILENE. During each experiment, several neutron activation foils and thermoluminescent dosimeters (TLDs) were placed around the reactor. Nearly half of the foils and TLDs had additional high-density magnetite concrete, high-density barite concrete, standard concrete, and/or BoroBond shields. CEA Saclay provided all the concrete, and the US Y-12 National Security Complex provided the BoroBond. Measurement data from the experiments were published at the 2011 International Conference on Nuclear Criticality (ICNC 2011) and the 2013 Nuclear Criticality Safety Division (NCSD 2013) topical meeting. Preliminary computational results for the first experiment were presented in the ICNC 2011 paper, which showed poor agreement between the computational results and the measured values of the foils shielded by concrete. Recently the hydrogen content, boron content, and density of these concrete shields were further investigated within the constraints of the previously available data. New computational results for the first experiment are now available

  14. Brasicáceas y perspectivas de control biológico del insecto plaga Plutella xylostella (Lepidóptera: Plutellidae utilizando Bacillus thuringiensis

    Directory of Open Access Journals (Sweden)

    Julieth Mena Guerrero

    2017-09-01

    Full Text Available La Plutella xylostella (L. es un insecto plaga que afecta principalmente los cultivos de brasicáceas o crucíferas como el repollo, coliflor, brócoli y rábano, entre otros. Las limitaciones del rendimiento y calidad de estos cultivos se deben principalmente al difícil manejo de esta plaga. En la actualidad, para controlar la P. xylostella se utilizan insecticidas de síntesis química, como piretroides, carbamatos u organofosforados, los cuales tienen acción inmediata pero causan efectos adversos en la salud y en el ambiente. Adicionalmente, la ausencia de enemigos naturales capaces de controlar a sus poblaciones, y su resistencia a numerosos insecticidas convencionales hacen que este insecto se establezca rápidamente en áreas productoras de brasicáceas. Se calcula que los costos mundiales asociados al control de la P. xylostella, sumados a las pérdidas en la producción agrícola, están entre cuatro y cinco billones de dólares anuales. Se han propuesto alternativas seguras, efectivas y de menor impacto ambiental, como el control biológico, que permite la producción sostenible de los cultivos de brasicáceas. La industria agrícola y forestal reconoce a la bacteria entomopatógena Bacillus thuringiensis (Bt como una buena alternativa biológica a los insecticidas químicos, puesto que es inocua sobre el ambiente y su toxicidad es altamente selectiva, ligada a su estrecho rango de especificidad sobre diferentes insectos plaga de los órdenes Lepidóptera, Coleóptera y Díptera. En esta revisión se presentan las posibilidades actuales que se pueden emplear para el control de la P. xylostella utilizando modelos investigativos basados en ensayos biológicos con Bt. Dichas posibilidades buscan superar las desventajas existentes en relación con la plaga P. xylostella y los cultivos de brasicáceas, además de entender la fisiología de Bt bajo condiciones que permitan incrementar la eficacia en el control biológico.

  15. Association of Neisseria gonorrhoeae Opa(CEA with dendritic cells suppresses their ability to elicit an HIV-1-specific T cell memory response.

    Directory of Open Access Journals (Sweden)

    Qigui Yu

    Full Text Available Infection with Neisseria gonorrhoeae (N. gonorrhoeae can trigger an intense local inflammatory response at the site of infection, yet there is little specific immune response or development of immune memory. Gonococcal surface epitopes are known to undergo antigenic variation; however, this is unlikely to explain the weak immune response to infection since individuals can be re-infected by the same serotype. Previous studies have demonstrated that the colony opacity-associated (Opa proteins on the N. gonorrhoeae surface can bind human carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1 on CD4⁺ T cells to suppress T cell activation and proliferation. Interesting in this regard, N. gonorrhoeae infection is associated with impaired HIV-1 (human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte (CTL responses and with transient increases in plasma viremia in HIV-1-infected patients, suggesting that N. gonorrhoeae may also subvert immune responses to co-pathogens. Since dendritic cells (DCs are professional antigen presenting cells (APCs that play a key role in the induction of an adaptive immune response, we investigated the effects of N. gonorrhoeae Opa proteins on human DC activation and function. While morphological changes reminiscent of DC maturation were evident upon N. gonorrhoeae infection, we observed a marked downregulation of DC maturation marker CD83 when the gonococci expressing CEACAM1-specific Opa(CEA, but not other Opa variants. Consistent with a gonococcal-induced defect in maturation, Opa(CEA binding to CEACAM1 reduced the DCs' capacity to stimulate an allogeneic T cell proliferative response. Moreover, Opa(CEA-expressing N. gonorrhoeae showed the potential to impair DC-dependent development of specific adaptive immunity, since infection with Opa(CEA-positive gonococci suppressed the ability of DCs to stimulate HIV-1-specific memory CTL responses. These results reveal a novel mechanism to explain

  16. Vegetación espontánea preferida por hormigas cortadoras en plantaciones de Salicáceas en el Delta del Paraná

    OpenAIRE

    Perri, Daiana; Casaubón, Edgardo; Gorosito, Norma; Gurini, Laura Beatriz; Fernández, Patricia Carina

    2015-01-01

    La vegetación de crecimiento espontáneo, llamada “maleza” es considerada perjudicial para las plantaciones de sauce y álamo. Las hormigas cortadoras de hojas (Acromyrmex sp.) son una de las plagas más importantes en la producción de Salicáceas y son combatidas con insecticidas de síntesis que contaminan el ambiente. El objetivo de este trabajo fue comenzar a evaluar las plantas cortadas por las hormigas en el campo y realizar ensayos de preferencia con el fin de proponer especies como cultivo...

  17. FENOLOGÍA DE CUATRO ESPECIES DE CACTÁCEAS DEL CERRO UMARCATA. VALLE DEL RÍO CHILLÓN. CANTA-LIMA. PERÚ

    OpenAIRE

    Ramírez-Bullón, Natali; Jardín Botánico “Octavio Velarde Núñez”. Departamento Académico de Biología, Universidad Nacional Agraria La Molina (Perú).; Ceroni-Stuva, Aldo; Jardín Botánico “Octavio Velarde Núñez”. Departamento Académico de Biología, Universidad Nacional Agraria La Molina. Av. La Molina s/n, Lima 12, Perú. Apartado postal: 12-056, Perú.; Castro-Cepero, Viviana; Jardín Botánico “Octavio Velarde Núñez”. Departamento Académico de Biología, Universidad Nacional Agraria La Molina. Av. La Molina s/n, Lima 12, Perú. Apartado postal: 12-056, Perú.

    2014-01-01

    Se estudiaron cuatro especies de cactáceas: Esposta melanostele, Haageocereus pseudomelanostele subsp. aureispinus, Melocactus peruvianus y Neoraimondia arequipensis subsp. roseiflora, presentes en el ecosistema árido Cerro Umarcata, Valle del Río Chillón, Canta- Lima. Se encontraron dos fenofases, floración y fructificación con ocho estadios fenológicos entre Octubre 2006 y Setiembre 2007. Para la fenofase de floración, los estadios fenológicos Flor Marchita y Botón Abortado fueron dominante...

  18. Nuevas tecnologías desarrolladas para el aprovechamiento de las cactáceas en la elaboración de alimentos. Componentes funcionales y propiedades antioxidantes

    OpenAIRE

    Mónica Azucena Nazareno; Carlos Alberto Padrón Pereira

    2011-01-01

    Las cactáceas han sido consideradas por nuestros ancestros y contemporáneos una fuente de alimento y también de medicinas. La mayoría presenta frutos y cladodios comestibles que a su vez pueden ser procesados a una amplia variedad de nuevos productos. Se ha demostrado que su consumo ofrece beneficios nutricionales y promueve la salud, y debido a esto existe un marcado interés en el desarrollo de nuevas tecnologías y la adquisición de nuevos conocimientos sobre su naturaleza química y propieda...

  19. Elaboration of an alpha-numeric classification for file of matters of the documentation service of the CEA; Elaboration d'une classification alfha-numerique pour le fichier matieres du service de documentation du Commissariat a l'Energie Atomique

    Energy Technology Data Exchange (ETDEWEB)

    Braffort, P. [Commissariat a l' Energie Atomique, Saclay(France). Centre d' Etudes Nucleaires

    1953-07-01

    We give the principles of a classification of matters to square basis, suiting the needs of the Service, of Documentation of the C.E.A. We present the detail of the categories in the order of the 'columns', likewise the big scientific subdivisions at the CEA. (authors) [French] On donne les principes d'une classification matieres a base carree, convenant aux besoins du Service de Documentation du C.E.A. On presente ensuite le detail des rubriques dans l'ordre des ''colonnes'', c'est-a-dire, des grandes subdivisions scientifiques du C.E.A. (auteurs)

  20. ACCELERATED AGING OF OLERACEOUS SPECIES SEEDS ENVELHECIMENTO ACELERADO DE SEMENTES DE ESPÉCIES OLERÁCEAS

    Directory of Open Access Journals (Sweden)

    Denis Santiago da Costa

    2011-07-01

    the seedling formation process.

    A qualidade da semente utilizada no processo de produção agrícola é um dos principais fatores considerados para a implantação da cultura. Este trabalho objetivou estudar o efeito do nível de vigor no desempenho de sementes de seis espécies oleráceas. Sementes comerciais de alface, berinjela, brócolis, couve-flor, rúcula e tomate foram submetidas ao envelhecimento acelerado, por 48 e 72 horas, para obtenção de lotes com três níveis de vigor. Obteve-se um lote normal e dois envelhecidos por diferentes períodos. Após a obtenção dos lotes, as sementes foram submetidas a testes de germinação, condutividade elétrica, emergência de plântulas em bandeja, comprimento e massa seca de plântulas. O efeito do envelhecimento acelerado torna-se mais acentuado com o aumento do tempo de exposição das sementes às condições de alta umidade relativa do ar e elevada temperatura. Esta exposição reduz, mais acentuadamente, a qualidade das sementes para algumas espécies, como alface, couve-flor e rúcula, que para outras, como brócolis, tomate e berinjela. Sementes de menor vigor, além de menor germinação e menor emergência, apresentam lentidão no processo de formação de mudas.

  1. Enterobacteriáceas en partes externas del estadío adulto de Periplaneta americana “cucaracha” capturadas en el mercado Modelo, Iquitos, Perú

    Directory of Open Access Journals (Sweden)

    Xandrix Augusto Ruiz Cabezas

    2015-06-01

    Full Text Available Este estudio, determinó la presencia de Enterobacteriáceas en partes externas del estadío adulto de Periplaneta americana “cucaracha” capturadas en el mercado Modelo de la ciudad de Iquitos. Fueron colectados un total de 68 “cucarachas”, y luego cada una fue depositada en un frasco estéril y trasladadas vivas para el análisis respectivo al laboratorio de Investigación de la Facultad de Ciencias Biológicas; después del aislamiento, las colonias observadas fueron sometidas a pruebas de identificación bioquímica tales como: Prueba de oxidasa, utilización de glucosa, lactosa y sacarosa (agar TSI, pruebas VP-RM, indol, hidrólisis de la úrea. La prevalencia de Enterobacteriáceas se determinó utilizando el método estadístico de distribución de frecuencias y la prueba no paramétrica de Chi cuadrado para prueba de hipótesis. De las 68 cucarachas analizadas se aislaron 118 colonias caracterizadas como lactosa positiva y lactosa negativa, representando el 71 % y 29 % respectivamente de las muestras analizadas.  Finalmente, se aisló e identificó 5 cepas bacterianas, categorizadas en 5 géneros: Providencia (25%, Edwardsiella (9%, Citrobacter (14%, Enterobacter (31% y Klebsiella (21%.

  2. The effect of high level natural ionizing radiation on expression of PSA, CA19-9 and CEA tumor markers in blood serum of inhabitants of Ramsar, Iran.

    Science.gov (United States)

    Heidari, Mohammad Hassan; Porghasem, Mohsen; Mirzaei, Nazanin; Mohseni, Jafar Hesam; Heidari, Matine; Azargashb, Eznollah; Movafagh, Abolfazl; Heidari, Reihane; Molouki, Aidin; Larijani, Leila

    2014-02-01

    Since several high level natural radiation areas (HLNRAs) exist on our planet, considerable attention has been drawn to health issues that may develop as the result of visiting or living in such places. City of Ramsar in Iran is an HNLRA, and is a tourist attraction mainly due to its hot spas. However, the growing awareness over its natural radiation sources has prompted widespread scientific investigation at national level. In this study, using an ELISA method, the level of expression of three tumor markers known as carcinoembryonic antigen (CEA), prostate-specific antigen (PSA) and carcino antigen 19-9 (CA19-9) in blood serum of 40 local men of Ramsar (subject group) was investigated and compared to 40 men from the city of Noshahr (control group). Noshahr was previously identified as a normal level natural radiation area (NLNRA) that is some 85 km far from Ramsar. According to statistical analysis, there was a significant difference in the levels of PSA and CA19-9 markers between the two groups (p Ramsar being considerably higher. CEA level did not show any difference. Although some of the volunteers tested positive to the markers, they were in good health as confirmed by the physician. Moreover, the high number of positive markers in Noshahr was considerable. Therefore, future study is needed to further validate this result and to determine the level of positivity to tumor markers in both cities. Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. Chemistry of complexing molecules and environment. Report of the working group of the Cea ''mission environment''; Chimie des complexants en environnements. Rapport du groupe de travail de la mission environnement

    Energy Technology Data Exchange (ETDEWEB)

    Petit, J.C

    1998-07-01

    The Working group 'Chemistry of Complexing Molecules and Environment' of the Mission Environment (AG/ENV) identified themes for an original positioning of CEA on important issues of environmental research if a sufficiently strong demand appears. The research of CEA on the environment should be complementary to actions undertaken by other partners (official institutions, research organizations and industrial firms). The themes suggested are: the synthesis of new chelating molecules and new materials having specific properties, with the support of theoretical chemistry and modeling, analytical physical chemistry and speciation of species in relation to their eco-toxicity and their biogeochemical mobility in the natural environment. These themes, illustrated by examples of actions in progress at CEA or likely to be launched quickly, draw largely from recognized competences of the teams, generally developed for finalized nuclear applications: experimental, theoretical and instrumental competences. (author)

  4. Vulnerabilidad de los sistemas de polinización de cactáceas columnares de México Vulnerability of pollination systems of columnar cacti of Mexico

    Directory of Open Access Journals (Sweden)

    Alfonso Valiente-Banuet

    2002-03-01

    Full Text Available Se presenta un análisis geográfico sobre el grado de vulnerabilidad de los sistemas de polinización de cactáceas columnares de México que muestran un síndrome de polinización quiropterófila. Se partió del supuesto que sistemas especializados de polinización serían más vulnerables a la perturbación humana que los generalistas. Los resultados indican que las especies que se ubican en el límite norte de la distribución de las cactáceas columnares muestran patrones generalistas de polinización que las hace menos vulnerables a las perturbaciones que las que habitan el centro de México que presentan sistemas de interacción especializados. Este patrón contrastante podría estar relacionado con los movimientos migratorios de los murciélagos en el norte de la distribución de las cactáceas que pudo haber restringido la respuesta hacia la especialización, en tanto que poblaciones residentes de murciélagos en el centro de México podrían haber favorecido la especialización localAn analysis of the degree of vulnerability of the pollination systems of Mexican columnar cacti showing a chiropterophyllous pollination syndrome was conducted, assuming that specialized pollination interactions would be more vulnerable to human perturbations. The results indicate that the species inhabiting the northern distribution limit of the columnar cacti show generalized pollination systems whereas species inhabiting central Mexico showing specialized pollination interactions would be more vulnerable to perturbations. This contrasting geographic pattern might be related to the migratory movements of the nectar-feeding bats in the northern limit of distribution of the columnar cacti that restricted local specialization, whereas resident nectar-feeding bat populations in south-central Mexico probably favored local specialization

  5. Caracterización y respuesta al tratamiento térmico de rocas silíceas opalinas

    Directory of Open Access Journals (Sweden)

    Bustillo, María A.

    2000-12-01

    opalinas de diferentes ámbitos sedimentarios e hidrotermales se estudian mediante difracción de rayos X (DRX y espectrometría de infrarrojos, analizando la respuesta del polvo natural y después de un tratamiento térmico a 1.050ºC durante 24 horas. El objetivo es la diferenciación de las distintas estructuras de la sílice que pueden aparecer en las rocas opalinas, las variaciones que presentan dichas estructuras, y su cambio ante los tratamientos térmicos. En la mayoría de las muestras, la fase silícea encontrada es la denominada ópalo CT. El ópalo CT es un interestratificado de cristobalita y tridimita de estructura compleja que responde, en los análisis de DRX ,con perfiles distintos, principalmente en el intervalo de 19º a 25º 2θ. Se definen tres tipos básicos en este intervalo que se denominan “perfiles ensanchados (E, de hombro (H y de dos picos (2P”. Estos tipos tienen relación con la proporción de tridimita en el interestratificado (va aumentando desde los perfiles ensanchados a los de dos picos, el tamaño de cristal del ópalo (los ensanchados y los de hombro tienen menor tamaño, y la reactividad ante los calentamientos a 1.050ºC (va siendo progresivamente menor desde los perfiles ensanchados a los de dos picos. Las muestras menos reactivas resultaron ser las que poseían mayor proporción de tridimita en el interestratificado. En espectrometría de infrarrojos, los ópalos CT no manifiestan diferencias importantes entre sí, pero las muestras con perfiles ensanchados y de hombro presentan organizaciones algo distintas y mayor proporción de agua. No se han encontrado variaciones entre las estructuras de los ópalos formados en ambiente hidrotermal y los formados a temperatura ambiental, aunque en algunas muestras hidrotermales aparece ópalo C o una cristobalita α independiente junto al ópalo CT. Durante los tratamientos térmicos tampoco aparecieron diferencias.

  6. Systems assessment of water savings impact of controlled environment agriculture (CEA) utilizing wirelessly networked Sense•Decide•Act•Communicate (SDAC) systems.

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, Jonathan T.; Baynes, Edward E., Jr.; Aguirre,Carlos (University of Texas at El Paso, El Paso, TX); Jordan, Jon (University of Arizona, Tucson, AZ); Giacomelli, Gene (University of Arizona, Tucson, AZ); Waggoner, Justin (New Mexico State University, Las Cruces, NM); Loest, Clint (New Mexico State University, Las Cruces, NM); Szumel, Leo; Nakaoka, Tyler; Pate, Ronald C.; Berry, Nina M.; Pohl, Phillip Isabio; Aguirre, Francisco Luis (Invernaderos y Maquinaria Aguirre, Cd., Aldama, Chihuahua, Mexico); Aguilar, Jose (University of Texas at El Paso, El Paso, TX); Gupta, Vipin P.; Ochoa, Juan (University of Texas at El Paso, El Paso, TX); Davis, Jesse Zehring; Ramos, Damian (University of Texas at El Paso, El Paso, TX)

    2005-02-01

    Reducing agricultural water use in arid regions while maintaining or improving economic productivity of the agriculture sector is a major challenge. Controlled environment agriculture (CEA, or, greenhouse agriculture) affords advantages in direct resource use (less land and water required) and productivity (i.e., much higher product yield and quality per unit of resources used) relative to conventional open-field practices. These advantages come at the price of higher operating complexity and costs per acre. The challenge is to implement and apply CEA such that the productivity and resource use advantages will sufficiently outweigh the higher operating costs to provide for overall benefit and viability. This project undertook an investigation of CEA for livestock forage production as a water-saving alternative to open-field forage production in arid regions. Forage production is a large consumer of fresh water in many arid regions of the world, including the southwestern U.S. and northern Mexico. With increasing competition among uses (agriculture, municipalities, industry, recreation, ecosystems, etc.) for limited fresh water supplies, agricultural practice alternatives that can potentially maintain or enhance productivity while reducing water use warrant consideration. The project established a pilot forage production greenhouse facility in southern New Mexico based on a relatively modest and passive (no active heating or cooling) system design pioneered in Chihuahua, Mexico. Experimental operations were initiated in August 2004 and carried over into early-FY05 to collect data and make initial assessments of operational and technical system performance, assess forage nutrition content and suitability for livestock, identify areas needing improvement, and make initial assessment of overall feasibility. The effort was supported through the joint leveraging of late-start FY04 LDRD funds and bundled CY2004 project funding from the New Mexico Small Business Technical

  7. Morfometría de semillas en la cactácea amenazada de extinción Astrophytum myriostigma Lemaire

    Directory of Open Access Journals (Sweden)

    Jaime Sánchez-Salas

    2015-07-01

    Full Text Available Se presenta un estudio morfométrico y microestructural en semillas de una población de la cactácea amenazadaAstrophytum myriostigmaLem., removida en su tota- lidad en el sitio por saqueo. Se incluyen resultados que separan tamaños de semillas y embriones (grandes y pequeños así como promedios para ambos. Se realizó una descripción de características en la semilla obtenidas mediante estereoscopía. Se incluye una descripción detallada de la forma y color, así como microestructural del funículo, capa funicular y otras estructuras que le acompañan.

  8. Key Performance Criteria Affecting the Most the Safety of a Nuclear Waste Long Term Storage : A Case Study Commissioned by CEA

    Energy Technology Data Exchange (ETDEWEB)

    Marvy, A.; Lioure, A; Heriard-Dubreuil, G.; Gadbois, S.; Schneider, T.; Schieber, C.

    2003-02-24

    As part of the work scope set in the French law on high level long lived waste R&D passed in 1991, CEA is conducting a research program to establish the scientific basis and assess the feasibility of long term storage as an option for the safe management of nuclear waste for periods as long as centuries. This goal is a significant departure from the current industrial practice where storage facilities are usually built to last only a few decades. From a technical viewpoint such an extension in time seems feasible provided care and maintenance is exercised. Considering such long periods of time, the risk for Society of loosing oversight and control of such a facility is real, which triggers the question of whether and how long term storage safety can be actually achieved. Therefore CEA commissioned a study (1) in which MUTADIS Consultants (2) and CEPN (3) were both involved. The case study looks into several past and actual human enterprises conducted over significant periods o f time, one of them dating back to the end of the 18th century, and all identified out of the nuclear field. Then-prevailing societal behavior and organizational structures are screened out to show how they were or are still able to cope with similar oversight and control goals. As a result, the study group formulated a set of performance criteria relating to issues like responsibility, securing funds, legal and legislative implications, economic sustainable development, all being areas which are not traditionally considered as far as technical studies are concerned. These criteria can be most useful from the design stage onward, first in an attempt to define the facility construction and operating guiding principles, and thereafter to substantiate the safety case for long term storage and get geared to the public dialogue on that undertaking should it become a reality.

  9. Repeated adjuvant anti-CEA radioimmunotherapy after resection of colorectal liver metastases: Safety, feasibility, and long-term efficacy results of a prospective phase 2 study.

    Science.gov (United States)

    Sahlmann, Carsten-O; Homayounfar, Kia; Niessner, Martin; Dyczkowski, Jerzy; Conradi, Lena-Christin; Braulke, Friederike; Meller, Birgit; Beißbarth, Tim; Ghadimi, B Michael; Meller, Johannes; Goldenberg, David M; Liersch, Torsten

    2017-02-15

    In previous work, a single administration of anticarcinoembryonic antigen (anti-CEA) 131 I-labetuzumab radioimmunotherapy (RIT) after complete resection of colorectal liver metastases was well tolerated and significantly improved survival compared with controls. In the current phase 2 trial, the authors studied repeated RIT in the same setting, examining safety, feasibility, and efficacy. Sixty-three patients (median age, 64.5 years) received RIT at 40 to 50 millicuries/m2 per dose. Before the receipt of RIT, restaging was performed with computed tomography/magnetic resonance imaging and 18 F-fluorodeoxyglucose-positron emission to confirm that patients were "truly adjuvant." Patients who had elevated serum CEA levels or radiographically inconclusive new lesions were classified as "possibly nonadjuvant," but they also received RIT. Time to progression (TTP), overall survival (OS), and cause-specific survival (CSS) were calculated. The median follow-up was 54 months. After the first course of RIT, 14 of 63 patients experienced National Cancer Institute Common Toxicity Criteria grade 4 hematotoxicity; 19 patients did not receive the second course of RIT because of impaired performance status (N = 5) or relapse (N = 14). After the second course of RIT, 9 of 44 patients experienced National Cancer Institute Common Toxicity Criteria grade 4 hematotoxicity. Five patients developed myelodysplastic syndrome (MDS) from 22 to 55 months after their last RIT. The median TTP, OS, and CSS for all patients were 16, 55, and 60 months, respectively. The "truly adjuvant" patients (N = 39) had an improved median TTP (not reached vs 6.1 months; hazard ratio, 0.12; P Cancer 2017;123:638-649. © 2016 American Cancer Society. © 2016 American Cancer Society.

  10. The Diagnostic Value of Transvaginal Sonograph (TVS), Color Doppler, and Serum Tumor Marker CA125, CEA, and AFP in Ovarian Cancer.

    Science.gov (United States)

    Zhang, Fang; Zhang, Zhou-Long

    2015-06-01

    The purpose of this study is to investigate the diagnostic value of transvaginal sonograph (TVS), color Doppler, and serum tumor marker CA125, CEA, and AFP in ovarian cancer. From June, 2011 to May, 2013, 102 cases with adnexal mass were recruited in this study (32 cases of malignant ovarian cancer and 70 cases of benign ovarian tumor according to pathological diagnosis). TVS, color Doppler, and serum tumor markers were used for tumor diagnosis. The sensitivity, specifity, positive prediction, negative prediction, and Youden's index were analyzed. Of the 102 patients, 32 were diagnosed with malignant ovarian cancer and 70 were diagnosed with benign ovarian tumor according to pathological diagnosis. Based on TVS results, 37 cases were malignant while 65 cases were benign. Based on color Doppler results, 34 cases were malignant while 68 cases were benign. Based on TVS and color Doppler results, 35 cases were malignant while 65 were benign. Based on CA125 test results, 34 cases were malignant while 68 cases were benign. Based on CEA test results, 8 cases were malignant and 94 cases were benign. Bases on AFP test results, 9 cases were malignant while 93 cases were benign. Based on the results of combination tumor marker test, 38 cases were malignant while 64 cases were benign. The combination of TVS, color Doppler, and tumor marker test showed optimal diagnostic value with a sensitivity of 90.63 %, specificity of 97.14 %, positive prediction of 93.94 %, negative prediction of 98.55 %, and Youden's index of 94.02 %. The combination of TVS, color Doppler, and tumor marker test is of great diagnostic value, which should be widely used in clinical practice.

  11. Interpretation of sequential measurements of cancer antigen 125 (CA 125), carcinoembryonic antigen (CEA), and tissue polypeptide antigen (TPA) based on analytical imprecision and biological variation in the monitoring of ovarian cancer

    DEFF Research Database (Denmark)

    Tuxen, Malgorzata K.; Sölétormos, G; Petersen, P H

    2001-01-01

    The main objective with cancer antigen 125 (CA 125), carcinoembryonic antigen (CEA), and tissue polypeptide antigen (TPA) monitoring of ovarian cancer patients is to detect an early change of disease activity with high reliability. We hypothesized that a monitoring scheme for ovarian cancer patie...

  12. Balanced secretion of anti-CEA x anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity

    DEFF Research Database (Denmark)

    Mølgaard, Kasper; Compte, Marta; Alanes, Natalia Nuñez del Prado

    2017-01-01

    demonstrate that the incorporation of a 2A self-processing peptide derived from foot-and-mouth disease virus conveying co-translational cleavage into a two-chain anti-CD3 x anti-CEA diabody gene enables near-equimolar expression of diabody chains 1 and 2, and thus increases the final amount of assembled...

  13. Enraizamento de estacas herbáceas de guaranazeiro em diferentes substratos Survival rate of guarana herbaceous cuttings in different substrates

    Directory of Open Access Journals (Sweden)

    Murilo Rodrigues de Arruda

    2007-02-01

    Full Text Available A utilização de sementes na propagação do guaranazeiro propicia alta variabilidade na produtividade e suscetibilidade a doenças, por isto, no Amazonas, recomenda-se a propagação do guaranazeiro por meio do enraizamento de estacas herbáceas de materiais selecionados. Objetivou-se com este trabalho, avaliar o enraizamento, em tubetes, de estacas herbáceas de doze clones de guaranazeiro submetidas a três diferentes substratos. Os clones avaliados foram o BRS 300, BRS 871, BRS 372, BRS 648, BRS 189, BRS 505, BRS 610, BRS 612, BRS 850, BRS 882, BRS 608, BRS 611. Os substratos testados foram uma mistura com base em volume de 50 % de solo + 50 % de esterco de galinha (v/v; 50 % de esterco de galinha + 50 % de carvão moído passado em peneira de 10 mm (v/v e substrato comercial para hortaliças (Plantmax®. O substrato comercial e o esterco de galinha + carvão proporcionaram a maior porcentagem de enraizamento das estacas. O clone BRS Amazonas obteve o maior percentual de enraizamento (88,2 %, enquanto o clone BRS 372, o menor (15 %.The propagation of the guarana plants using seeds is nowadays not recommended because the high variability in the productivity and susceptibility to diseases. The cuttings propagation of a select guarana plant clones is recommended for Amazonas State. The objective of this study was to evaluate the survival rate of cuttings of twelve clones of guaraná in three substrates with three replicates. The evaluated clones were: BRS 300, BRS 871, BRS 372, BRS 648, BRS 189, BRS 505, BRS 610, BRS 612, BRS 850, BRS 882, BRS 608, BRS 611. The growing media tested were 50% of soil + 50% of chicken manure (v/v; 50% chicken manure + 50% sieved powdered charcoal (v/v and a comercial growing media for vegetables (Plantmax®. The comercial growing media and the misture of chicken manure + sieved powdered charcoal substrate produced the higher cuttings survival rate. The clone BRS Amazonas showed the highest percentage of survival

  14. Clorofíceas marinhas bentônicas da Praia de Serrambi, Pernambuco, Brasil Benthic marine Chlorophyceae from Serrambi Beach, Pernambuco, Brazil

    Directory of Open Access Journals (Sweden)

    Sônia Maria Barreto Pereira

    1998-04-01

    Full Text Available É apresentado o levantamento florístico sobre as clorofíceas marinhas bentônicas encontradas na Praia de Serrambi, litoral Sul do Estado de Pernambuco. O material estudado foi coletado em três estações, as quais foram visitadas mensalmente durante o período de abril de 1986 a setembro de 1987. As clorofíceas foram representadas na flora local por 39 espécies, três variedades e uma forma, pertencentes às ordens Ulotrichales, Ulvales, Siphonocladales, Cladophorales, Caulerpales e Dasycladales. Acetabularia calyculus Quoy & Gaimard. In Freycinet, Bryopsis pennata Lamouroux, Bryopsis plumosa (Hudson C. Agardh, Caulerpa ambigua Okamura, Caulerpa serrulata (Forsskål J. Agardh emend Børgesen, Chaetomorpha brachygona Harvey, Cladophora coelothrix Kützing, Cladophoropsis membranacea (C. Agardh Børgesen, Codium intertextum Collins & Hervey, Ernodesmis verticillata (Kützing Børgesen são novas referências para a flora do litoral de Pernambuco. Pringsheimiella scutata (Reinke von Höhnel ex Marchewianka o é também para o litoral continental do Brasil. Halimeda opuntia (L. Lamouroux foi hospedeira de maior número de epífitas, enquanto Bryopsis plumosa, quando epífita, foi a que cresceu sobre maior número de hospedeiros.This survey presents studies about benthics marine chlorophyceae found in the Serrambi Beach, South coast of Pernambuco. The material studied was collected in three stations, which were visited monthly during the period from April, 1986 to September, 1987. The chlorophyceae were represented in this flora by 39 species, three varieties and one form, from orders Ulotrichales, Ulvales, Siphonocladales, Cladophorales, Caulerpales and Dasycladales. Acetabularia calyculus Quoy & Gaimard. In Freycinet, Bryopsis pennata Lamouroux, Bryopsis plumosa (Hudson C. Agardh, Caulerpa ambigua Okamura, Caulerpa serrulata (Forsskål J. Agardh emend Børgesen, Chaetomorpha brachygona Harvey, Cladophora coelothrix Kützing, Cladophoropsis

  15. Improvement of the Targeting of Radiolabeled and Functionalized Liposomes with a Two-Step System Using a Bispecific Monoclonal Antibody (Anti-CEA × Anti-DTPA–In

    Directory of Open Access Journals (Sweden)

    Aurore eRauscher

    2015-11-01

    Full Text Available This study proposes liposomes as a new tool for pretargeted radioimmunotherapy (RIT in solid tumors. Tumor pretargeting is obtained by using a bispecific monoclonal antibody (BsmAb, anti-CEA x anti-DTPA-In and pegylated radioactive liposomes containing a lipid-hapten conjugate (DSPE-PEG-DTPA-In. In this work, the immunospecificity of tumor targeting is demonstrated both in vitro by fluorescence microscopy and in vivo by biodistribution studies.Methods: Carcinoembryonic antigen (CEA-expressing cells (LS174T were used either in cell culture or as xenografts in nude mice. Doubly fluorescent liposomes or doubly radiolabeled liposomes were respectively used for in vitro and in vivo studies. In each case, a tracer of the lipid bilayer (rhodamine or indium-111 (111In and a tracer of the aqueous phase (fluorescein or iodine-125 (125I were present. The targeting of liposomes was assessed with BsmAb for active targeting or without for passive targeting.Results: Data obtained with the lipid bilayer tracer showed a fluorescent signal on cell membranes two to three times higher for active than for passive targeting. This immunospecificity was confirmed in vivo with tumor uptake of 7.5 ± 2.4 % ID/g (percentage of injected dose per gram of tissue for active targeting versus 4.5 ± 0.45 % ID/g for passive targeting (p = 0.03. Regarding the aqueous phase tracer, results are slightly more contrasted. In vitro, the fluorescent tracer seems to be released in the extracellular matrix, which can be correlated with the in vivo data. Indeed, the tumor uptake of 125I is lower than that of 111In: 5.1 ± 2.5 % ID/g for active targeting and 2.7 ± 0.6 % ID/g for passive targeting, but resulted in more favorable tumor/organs ratios.Conclusion: This work demonstrated the tumor targeting immunospecificity of DSPE-PEG-DTPA-In liposomes by two different methods. This original and new approach suggests the potential of immunospecific targeting liposomes for the RIT of solid

  16. Anti-CEA aptamers labeled with {sup 99m}Tc: encapsulation studies in long-circulating and pH-sensitive liposomes, biodistribution and imaging

    Energy Technology Data Exchange (ETDEWEB)

    Leonel, M.F.V.; Andrade, A.S.R. [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Oliveira, M.C.; Cardoso, V.N.; Barros, A.L.B. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Faculdade de Farmacia

    2015-07-01

    Colorectal cancer (CRC) is one of the leading cancers and the carcinoembryonic antigen (CEA) is a tumor marker widely used in diagnosis since it is overexpressed in tumor cells. Acid nucleic aptamers with high affinity and specificity for this antigen become promising molecules for CRC diagnosis by imaging. However, due to the action of nucleases in vivo, they have been investigated for association with liposomes, such as long-circulating and pH-sensitive liposomes (SPHL) that can be destabilized in the tumor region releasing aptamers and contributing to the CRC diagnosis by scintigraphy. In this work, SpHL containing DOPE, CHEMS and mPEG{sub 2000}-DSPE were characterized by analyzing mean diameter, polydispersity index and zeta potential. The anti-CEA aptamers Apt3 and Apt3-Amino were labeled with technetium-99m and the encapsulation efficiency (EE) of {sup 99m}Tc-Apt3 in the SpHL by dehydration-rehydration (modified DRV) and freeze-thaw (FT) were analyzed, both in the presence of cryoprotectants. Biodistribution and scintigraphic images were performed at 1h and 4h post-injection of {sup 99m}Tc-Apt3-amino, {sup 99m}Tc-Apt3-SpHL or {sup 99m}Tc-Apt3-amino-SpHL complexes in Balb/c healthy mice. The SpHL dispersions were homogeneous. The radiolabeling yield with technetium-99m was over 90% for all complexes. By the dehydration-rehydration method, the SpHL increased over 200% after encapsulation procedure. By the freeze-thaw method, the SpHL size increased only 13.7%. Free {sup 99m}Tc-Apt3-amino showed to be cleared by renal via with high levels of radioactivity in the kidney and bladder, however, the {sup 99m}Tc-Apt3-SpHL and {sup 99m}Tc-Apt3-amino-SpHL clearly indicated high uptake by liver and spleen. The biodistribution of {sup 99m}Tc-Apt3-SpHL showed significant uptake of radioactivity by stomach and thyroid indicating less stability of the Apt3 radiolabelling in relation to Apt3-amino. (author)

  17. Efeito do armazenamento a frio e desidratação sobre o enraizamento de estacas herbáceas de Dendranthema grandiflora

    Directory of Open Access Journals (Sweden)

    Natalia Teixeira Schwab

    2013-02-01

    Full Text Available O experimento foi desenvolvido no setor de floricultura do Departamento de Fitotecnia da Universidade Federal de Santa Maria – Santa Maria, RS, no período de novembro a dezembro de 2007 e teve como objetivo avaliar o efeito do armazenamento a frio e da desidratação sobre o enraizamento de estacas herbáceas de Dendranthema grandiflora, cultivares ‘Satllion’ e ‘Toon Hermans’, tratadas com Ácido Indol Butírico (AIB 0,1%. As estacas herbáceas foram coletadas no matrizeiro localizado no Setor de Floricultura, apresentando 6 cm de comprimento final, e foram então armazenadas a frio por diferentes períodos de tempo (0; 7; 14 e 21 dias, sendo que cada tratamento constou de 20 repetições. As estacas depois de tratadas com AIB 0,1% foram pesadas antes e após o armazenamento para obter o percentual de perda de umidade e, logo após, foram plantadas em bandejas de enraizamento contendo casca de arroz carbonizada e colocadas em estufa onde permaneceram 15 dias até sua avaliação. Para a avaliação do efeito da estocagem a frio e desidratação, foram realizadas as seguintes medições: comprimento total das raízes nas estacas e número de raízes por estaca. Os resultados obtidos neste trabalho mostraram que certo nível de frio é favorável ao enraizamento, porém este efeito deve ser observado quanto a cultivar e ao tempo de exposição das estacas às baixas temperaturas. Além disso, foi possível observar que a capacidade de formação e crescimento das raízes pelas estacas é um caráter varietal, o que determina um melhor desempenho das plantas.

  18. Las Calamitáceas españolas. Índice taxonómico y clave analítica

    Directory of Open Access Journals (Sweden)

    Diéguez, M. C.

    1986-02-01

    Full Text Available The present work consists of the check-list of the Calamitae para-espcies collected in Spain with the synonims used. These have been compiled in a1phabetical order for case of reference. and is followed by an evaluation of them, considering some elected characters for its rapid identification, with whose we have made one key the para-species, which, helps its determination from the collecting place.

    En el presente trabajo se realiza un índice taxonómico de para-especies de Calamitáceas recogidas en España, con sus principales sinonimias. disponiéndose en orden alfabético para facilitar su utilización. Este índice es seguido por una evaluación de dichas para-especies. en atención a caracteres que faciliten su identificación y a partir de los cuales proponemos una clave analítica, que permita su determinación en el lugar de recogida.

  19. Nuevas tecnologías desarrolladas para el aprovechamiento de las cactáceas en la elaboración de alimentos. Componentes funcionales y propiedades antioxidantes

    Directory of Open Access Journals (Sweden)

    Mónica Azucena Nazareno

    2011-06-01

    Full Text Available Las cactáceas han sido consideradas por nuestros ancestros y contemporáneos una fuente de alimento y también de medicinas. La mayoría presenta frutos y cladodios comestibles que a su vez pueden ser procesados a una amplia variedad de nuevos productos. Se ha demostrado que su consumo ofrece beneficios nutricionales y promueve la salud, y debido a esto existe un marcado interés en el desarrollo de nuevas tecnologías y la adquisición de nuevos conocimientos sobre su naturaleza química y propiedades para un mejor aprovechamiento, lo que genera nuevos estudios. En tal sentido, en este trabajo se recopiló información de la literatura que fue revisada, con el propósito de aportar una visión general sobre las nuevas tecnologías desarrolladas para el aprovechamiento de los cactus en la elaboración de alimentos con énfasis en sus componentes bioactivos y propiedades antioxidantes. Se concluye que un amplio espectro de nuevas tecnologías está siendo explorado a fin de obtener alimentos cuya función no sea solamente un aporte nutricional sino también que represente un beneficio para la salud de los consumidores.

  20. Nuevas tecnologías desarrolladas para el aprovechamiento de las cactáceas en la elaboración de alimentos. Componentes funcionales y propiedades antioxidantes

    Directory of Open Access Journals (Sweden)

    Mónica Azucena Nazareno

    2011-01-01

    Full Text Available Las cactáceas han sido consideradas por nuestros ancestros y contemporáneos una fuente de alimento y también de medicinas. La mayoría presenta frutos y cladodios comestibles que a su vez pueden ser procesados a una amplia variedad de nuevos productos. Se ha demostrado que su consumo ofrece beneficios nutricionales y promueve la salud, y debido a esto existe un marcado interés en el desarrollo de nuevas tecnologías y la adquisición de nuevos conocimientos sobre su naturaleza química y propiedades para un mejor aprovechamiento, lo que genera nuevos estudios. En tal sentido, en este trabajo se recopiló información de la literatura que fue revisada, con el propósito de aportar una visión general sobre las nuevas tecnologías desarrolladas para el aprovechamiento de los cactus en la elaboración de alimentos con énfasis en sus componentes bioactivos y propiedades antioxidantes. Se concluye que un amplio espectro de nuevas tecnologías está siendo explorado a fin de obtener alimentos cuya función no sea solamente un aporte nutricional sino también que represente un beneficio para la salud de los consumidores.

  1. Evaluation of the use of decision-support software in carcino-embryonic antigen (CEA-based follow-up of patients with colorectal cancer

    Directory of Open Access Journals (Sweden)

    Verberne Charlotte J

    2012-03-01

    Full Text Available Abstract Background The present paper is a first evaluation of the use of "CEAwatch", a clinical support software system for surgeons for the follow-up of colorectal cancer (CRC patients. This system gathers Carcino-Embryonic Antigen (CEA values and automatically returns a recommendation based on the latest values. Methods Consecutive patients receiving follow-up care for CRC fulfilling our in- and exclusion criteria were identified to participate in this study. From August 2008, when the software was introduced, patients were asked to undergo the software-supported follow-up. Safety of the follow-up, experiences of working with the software, and technical issues were analyzed. Results 245 patients were identified. The software-supported group contained 184 patients; the control group contained 61 patients. The software was safe in finding the same amount of recurrent disease with fewer outpatient visits, and revealed few technical problems. Clinicians experienced a decrease in follow-up workload of up to 50% with high adherence to the follow-up scheme. Conclusion CEAwatch is an efficient software tool helping clinicians working with large numbers of follow-up patients. The number of outpatient visits can safely be reduced, thus significantly decreasing workload for clinicians.

  2. Determinação do antígeno carcinoembrionário biliar na detecção das metástases hepáticas do carcinoma colorretal Carcinoembryonic antigen (CEA determination in detection of hepatic metastasis from colorectal carcinoma

    Directory of Open Access Journals (Sweden)

    Adriana Polycarpo

    2003-01-01

    Full Text Available OBJETIVO: Analisar, prospectivamente, os resultados da determinação do antígeno carcinoembriário (CEA na bile vesicular, relacionando-os com os aspectos morfológicos e clínicos da neoplasia e recidiva hepática. MÉTODOS: Os níveis do CEA foram estudados na bile vesicular e no sangue periférico de 44 doentes com carcinoma colorretal e 10 com colelitíase não complicada, a partir de amostras do CEA colhidas imediatamente antes da extirpação da neoplasia colo-retal e da colecistectomia (considerou-se valor normal até 5 ng/ml. RESULTADOS: Os 44 carcinomas colorretais extirpados com intenção curativa tiveram nível médio do CEA sérico de 8,5 ng/ml e CEA biliar, 74,5 ng/ml. Nas colelitíases não complicadas submetidas a colecistectomia, o nível médio do CEA sérico foi de 1,9 ng/ml e CEA biliar, 1,2 ng/ml. Quatro doentes submetidos à extirpação do carcinoma colo-retal, sem evidências de metástases hepáticas e com valor médio de CEA biliar de 213,2 ng/ml apresentaram metástases hepáticas entre três a 17 meses após a extirpação. CONCLUSÃO: o nível elevado de CEA biliar dos operados por carcinoma colo-retal pode indicar presença de metástases hepáticas e esses enfermos devem ser acompanhados com especial atenção para diagnosticar essas lesões.PURPOSE: Carcinoembryonic antigen (CEA determination in gallbladder bile was used in a prospective study concerning the morphological and clinical features of the neoplasm and the occurrence of hepatic metastasis. METHODS: CEA levels in the gallbladder and peripheral blood were studied in 44 patients with colorectal carcinoma and 10 patients with uncomplicated cholelithiasis from samples collected immediately before extirpating the colorectal neoplasms or cholecystectomy (values of up to 5 ng/ml were considered normal. RESULTS: In the 44 patients with colorectal carcinoma who underwent operation with curative intent, the average level of serum CEA was 8.5 ng/ml and for bile

  3. A fundamental study of immunoscintigraphy with sup 131 I-labeled anti-CA 19-9 and anti-CEA monoclonal antibodies; Imaging of tumor-bearing mice by IMACIS-1 and cell ELISA with human tumor cells

    Energy Technology Data Exchange (ETDEWEB)

    Nogami, Toshihiko; Miura, Hiroshi; Ohmi, Shoichi; Kazahaya, Yasuhiro (CIS DIAGNOSTIC K.K., Chiba (Japan))

    1990-05-01

    A study was made on 2 types of {sup 131}I-labeled anti-CA 19-9 and anti-CEA mouse monoclonal antibodies (IMACIS-1) against human cancer related antigen as to their usefulness in radioimmunoimaging. Tumor-bearing nude mice were used for comparison. The transplanted tumors (SW948, COLO 201) were clearly visualized 48-72 hours after administration of IMACIS-1. Tumor/blood ratio 72 hours after administration: 8.69 in COLO 201 and 5.70 in SW948, showing ca. 10-15 times as high as those in PC-3 and HEp-2. IMACIS-1 therefore is considered useful in radioimmunoimaging of cancer. Analysis was made by in vitro cell ELISA. As a result, both of the cells specifically reacted with anti-CA 19-9 but not anti-CEA. (author).

  4. Uso da capilaroscopia ungueal como método diagnóstico e prognóstico de rosácea Nailfold capillaroscopy as a diagnostic and prognostic method in rosacea

    Directory of Open Access Journals (Sweden)

    Gabriela Poglia Fonseca

    2011-02-01

    Full Text Available FUNDAMENTOS: Não há um método adequado e fidedigno de avaliação e seguimento da severidade na rosácea. OBJETIVO: Determinar a importância da capilaroscopia periungueal como método diagnóstico e prognóstico em pacientes portadores de rosácea. MÉTODOS: Estudo transversal onde foram submetidos ao exame da capilaroscopia periungueal 8 pacientes com rosácea e 8 controles no período entre maio e julho de 2009. Foram coletados dados clínicos relacionados ao sexo, idade, fototipo, classificação da rosácea de acordo com a classificação de Plewig e Kligman e a classificação da National Rosacea Society. Adicionalmente, avaliamos o tempo de evolução da doença e tratamentos previamente utilizados. RESULTADOS: A grande maioria das pacientes avaliadas (6 das 8 pacientes apresentavam rosácea grau I (vascular ou eritêmato-teleangiectásica. A idade média de duração da rosácea foi de 5,96 anos, sendo que 87,5% faziam tratamento com metronidazol tópico. Nenhum paciente tanto do grupo rosácea como controle demonstrou evidência de desvascularização ao exame capilaroscópico. CONCLUSÃO: A capilaroscopia periungueal apresenta um padrão inespecífico e não parece auxiliar no diagnóstico ou prognóstico da rosácea.BACKGROUND: There is no appropriate and reliable method of evaluating and monitoring severity in rosacea. OBJECTIVE: To determine the importance of nailfold capillaroscopy as a diagnostic and prognostic method for patients with rosacea. METHODS: A cross-sectional study where eight patients with rosacea and 8 control subjects were submitted to nailfold capillaroscopy from May to July 2009. We collected clinical data related to gender, age, skin phototype, and rosacea stage according to Plewig and Kligman classification and the classification of the National Rosacea Society. Additionally, we evaluated the progression of the disease and treatment therapies previously used. RESULTS: The majority of the patients evaluated (6

  5. Achado incidental de glândula sebácea em colo uterino: provavelmente um processo metaplásico An incidental finding of sebaceous glands in the uterine cervix: a probable metaplastic process

    Directory of Open Access Journals (Sweden)

    Daniel Cury Ogata

    2012-06-01

    Full Text Available As glândulas sebáceas ectópicas são achados muito infrequentes no trato genital feminino. Descrevemos um caso que ocorreu em paciente de 42 anos de idade, submetida à histerectomia total, devido à leiomiomatose e ao prolapso uterino.The ectopic sebaceous glands have been extremely rare findings in female genital system. We describe the case of 42 years-old patient with total hysterectomy due to leiomyomatosis and uterine prolapsed.

  6. The evaluation of the year 1999. Report of the Safety Administrative Staff; Bilan 1999. Le rapport de la Direction centrale de la securite. Controle des rejets et surveillance de l'environnement des centres CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The environmental quality around the CEA's Centers is a constant care of its safety policy. In this context a continuously control of the effluents and the air is monitoring. In order to inform the public this report presents the evaluation of the liquid or gaseous radioactive effluents, for the year 1999. A part is devoted to the regulations and the methods used to control the environmental quality around the centers. (A.L.B.)

  7. PRODUÇÃO DE MUDAS DE VIDEIRA 'RUBI' PELO MÉTODO DE ENXERTIA DE MESA EM ESTACAS HERBÁCEAS DOS PORTA-ENXERTOS IAC 313 'TROPICAL' E IAC 766 'CAMPINAS'

    Directory of Open Access Journals (Sweden)

    REZENDE LEILA DE PAULA

    2001-01-01

    Full Text Available Com o objetivo de estudar o método de enxertia de mesa em estacas herbáceas para a obtenção de mudas de videira, experimentos foram desenvolvidos em câmara de nebulização, localizada no ripado do Departamento de Produção Vegetal da Faculdade de Ciências Agrárias e Veterinárias da UNESP, no período de novembro de 1997 a dezembro de 1999. Foram utilizadas estacas herbáceas dos porta-enxertos IAC 313 'Tropical' e IAC 766 'Campinas' e borbulhas e garfos da cultivar Rubi. Foram testados os métodos de enxertia de garfagem em fenda cheia e de borbulhia em placa, em estacas herbáceas sem raízes e enraizadas, o tipo de proteção do enxerto, o tamanho das estacas e o recipiente de enraizamento. Foram avaliados o enraizamento e o pegamento de enxertos. O método de enxertia de mesa com garfagem e com proteção do enxerto com saco plástico apresentou maior pegamento de enxerto aos 30 (45,25% e 60 dias (66,20% após a enxertia. O tamanho da estaca não afetou o pegamento dos enxertos. Contudo, em todos os experimentos, o índice de sobrevivência dos enxertos foi muito baixo ou nulo. Estacas sem enxertia proporcionaram maior porcentagem de enraizamento (65,62% em relação às estacas enxertadas. O método de enxertia de mesa em estacas herbáceas dos porta-enxertos IAC 313 'Tropical' e IAC 766 'Campinas' não foi eficiente para a formação de mudas de videira.

  8. Volumen y dimensiones como predictores del peso de semilla en especies herbáceas del centro de la Península Ibérica

    Directory of Open Access Journals (Sweden)

    Sánchez, Ana M.

    2001-12-01

    Full Text Available Although seed weight is a key factor in understanding the reproductive biology of plant species, its value is unknown for a large proportion of the herbaceous species in the Mediterranean basin. This paper presents data on seed weight, dimensions and volume for 1 18 herbaceous species in acidic Mediterranean scrub and grassland in the centre of the Iberian Peninsula. This information is used to design predictive models of seed weight using multiple regression models. taking into account the phylogenetic effect. Five groups of models were designed: one using Trifolium species. three. using the families represented by the largest number of species (Catyophyllaceae, Asteraceae and Poaceae; and finally a general model using one species from each of the families present in the sample. The models are rated according to the absorbed variante, their significance in relation to the previous in complexity and the effort required to obtain the data for each one. We also test the validity of seed dimension data taken from literature sources to predict seed weight. The 1-0 seed dimensions are excellent weight predictors in the case of Trifolium (Weight = - 24.55 + 0.10D1 + 3.38D2, r2 = 0.94 and Asteraceae (Weight = - 20.90 + 1.19D1 + 1.67D2, r2 = 0.91 and are quite satisfactory in the case of the general model (Weight = - 16.01 +0.56D1 + 1.6002, r2 = 0.69.El peso de las semillas es un carácter clave para entender la biología reproductiva de las especies vegetales, pero se desconoce su valor para gran parte de las especies herbáceas de la cuenca mediterránea. En este trabajo se exponen datos de peso, dimensiones y volumen de las semillas de 118 especies herbáceas características del matorral y pastizal acidófilos mediterráneos del centro de la Península Ibérica. Esta información es empleada para elaborar modelos predictivos del peso a partir de las dimensiones mediante el uso de modelos de regresión lineal múltiple, teniendo en cuenta el efecto

  9. Sensitivity of Symptomatology Versus Diagnostic Procedures and Concentration of CEA and CA19-9 in the Early Detection of Colorectal Cancer.

    Science.gov (United States)

    Vukobrat-Bijedic, Zora; Husic-Selimovic, Azra; Bijedic, Nina; Mujkic, Admir; Sofic, Amela; Gogov, Bisera; Mehmedovic, Amila; Bjelogrlic, Ivana; Glavas, Sanjin; Djuran, Aleksandra

    2014-04-01

    Colorectal cancer is the major diagnostic and therapeutic problem. The number of patients in the world has increased recently. In our country it is detected late and patients visit doctor in the advanced stage of the disease with already developed metastases. A clinical study was conducted at the Clinic of gastroenterohepatologists, Clinical Center of Sarajevo University on 164 patients. Special attention was given to the symptoms, which are considered to be a macroscopically visible as bleeding, anemia pain, weight loss and disturbance of defecation. Smoking had no effect because a small number of observed patients smoked. Endoscopic examination revealed localization of the tumor in the colon and then underwent targeted biopsy, histological analysis by pathologist, and we determined the concentration of CEA and CA19-9 in the serum. In order to get the most relevant results we used larger data set. The program used to prepare the data was Microsoft Excel 2013, and for the creation of decision trees is a used software RapidMiner version 5. Our research has shown that patients older than 55 years with significant stenosis, metastasis and diarrhea that lasted longer than 3.5 months and bleeding that lasted up to 10 months had cancer of the rectum. Bleeding that lasts longer than 10 months indicated that it was the case of cancer that was localized in the rectum in men and sigma in women. Patients older than 82.5 years and had diarrhea up to 3.5 months developed cancer in the sigma part of the colon. Analyzing pain as a symptom of an alarm, the study found that pain that lasts longer than a few days, is caused by rectal cancer, and occurs after the age of 70.5 years, and in patients younger than 63 years anemia as a alarm symptom, which lasted more than two months in men was caused by cancer of the rectum and in women cancer in other localizations within colon. In patients without stenosis developed bleeding as the most important symptom. We can say that after the age

  10. Sensitivity of Symptomatology Versus Diagnostic Procedures and Concentration of CEA and CA19–9 in the Early Detection of Colorectal Cancer

    Science.gov (United States)

    Vukobrat-Bijedic, Zora; Husic-Selimovic, Azra; Bijedic, Nina; Mujkic, Admir; Sofic, Amela; Gogov, Bisera; Mehmedovic, Amila; Bjelogrlic, Ivana; Glavas, Sanjin; Djuran, Aleksandra

    2014-01-01

    Introduction: Colorectal cancer is the major diagnostic and therapeutic problem. The number of patients in the world has increased recently. In our country it is detected late and patients visit doctor in the advanced stage of the disease with already developed metastases. Material and methods: A clinical study was conducted at the Clinic of gastroenterohepatologists, Clinical Center of Sarajevo University on 164 patients. Special attention was given to the symptoms, which are considered to be a macroscopically visible as bleeding, anemia pain, weight loss and disturbance of defecation. Smoking had no effect because a small number of observed patients smoked. Endoscopic examination revealed localization of the tumor in the colon and then underwent targeted biopsy, histological analysis by pathologist, and we determined the concentration of CEA and CA19-9 in the serum. Results: In order to get the most relevant results we used larger data set. The program used to prepare the data was Microsoft Excel 2013, and for the creation of decision trees is a used software RapidMiner version 5. Our research has shown that patients older than 55 years with significant stenosis, metastasis and diarrhea that lasted longer than 3.5 months and bleeding that lasted up to 10 months had cancer of the rectum. Bleeding that lasts longer than 10 months indicated that it was the case of cancer that was localized in the rectum in men and sigma in women. Patients older than 82.5 years and had diarrhea up to 3.5 months developed cancer in the sigma part of the colon. Analyzing pain as a symptom of an alarm, the study found that pain that lasts longer than a few days, is caused by rectal cancer, and occurs after the age of 70.5 years, and in patients younger than 63 years anemia as a alarm symptom, which lasted more than two months in men was caused by cancer of the rectum and in women cancer in other localizations within colon. In patients without stenosis developed bleeding as the most

  11. Comportamento de espécies herbáceas em misturas de solo com diferentes graus de contaminação com metais pesados

    Directory of Open Access Journals (Sweden)

    Carneiro Marco Aurélio Carbone

    2002-01-01

    Full Text Available O objetivo deste trabalho foi avaliar, em casa de vegetação, o comportamento de espécies herbáceas em relação ao excesso de Cd e Zn no solo. O gradiente de contaminação foi estabelecido a partir de mistura de solo contaminado com solo sem contaminação em diferentes proporções. As sementes foram semeadas em tubetes contendo 250 mL de solo, e após 90 dias as plantas foram colhidas e avaliadas. A maioria das espécies apresentou redução no crescimento com aumento da contaminação do solo e elevadas concentrações de Cd e Zn na matéria seca da parte aérea (MSPA, na mistura com 15% de solo contaminado. A espécie Pffafia sp. mostrou-se tolerante à contaminação, crescendo em misturas de solo contendo até 90 mg kg-1 de Cd e 1.450 mg kg-1 de zinco. Além disso, apresentou concentração superior a 100 mg kg-1 de Cd na MSPA, sendo considerada hiperacumuladora desse metal. Sida glaziovii, Bidens pilosa, Rhynchelytrum repens, Cenchrus echinatus e Nicandra physaloides, por sua vez, foram severamente afetadas pela contaminação, ao contrário de Trifolium repens, Euchlaena mexicana, Cynodon dactylon, Avena strigosa, Cenchrus ciliares e Cyperus sp. que apresentaram crescimento satisfatório. As espécies avaliadas mostram-se promissoras para estudos adicionais sobre a reabilitação de áreas contaminadas com metais pesados.

  12. Enraizamento de estacas herbáceas de 'mirabolano' (Prunus cerasifera ehrn em diferentes substratos e concentrações de ácido indolbutírico

    Directory of Open Access Journals (Sweden)

    Ramos José Darlan

    2003-01-01

    Full Text Available O presente trabalho foi realizado com o objetivo de testar diferentes dosagens de AIB (ácido indolbutírico e diferentes substratos no enraizamento de estacas herbáceas do porta-enxerto de ameixeira 'Mirabolano'. As estacas foram retiradas de plantas localizadas no município de Wenceslau Bráz-MG, sendo transportadas em câmara fria para a Fazenda Experimental da Epamig, localizada em Maria da Fé-MG, onde foram padronizadas com um par de meias-folhas e 12 cm de comprimento, sendo posteriormente imersas por 5 segundos em soluções contendo diferentes dosagens de AIB (0; 1000; 2000 e 4000 mg.L-1. Em seguida, foram levadas até bancadas contendo diferentes substratos (areia esterelizada e vermiculita, em local com 50% de sombreamento e umidade controlada, permanecendo sob estas condições por 60 dias. As variáveis analisadas foram: porcentagem de enraizamento, número de raízes, comprimento médio das raízes e biomassa seca das raízes. Observou-se maior eficiência da vermiculita na obtenção de estacas com maior comprimento médio das raízes e maior porcentagem de enraizamento. Quanto às demais variáveis, não houve diferença significativa entre o uso dos substratos em questão. Com relação à dosagem de AIB, a concentração de 2000 mg.L-1 mostrou-se superior às demais para todas as variáveis analisadas.

  13. Estudio de las comunidades de plantas herbáceas de las Islas Bonaerenses del Bajo Delta del Río Paraná (Argentina

    Directory of Open Access Journals (Sweden)

    Patricia Kandus

    2003-01-01

    Full Text Available El sector bonaerense del Bajo Delta del Río Paraná conforma un extenso humedal costero de agua dulce sometido a mareas (2.700 km2. El presente trabajo se propuso identificar y describir las comunidades de herbáceas nativas de las islas y proponer un modelo conceptual que permita interpretar la expresión espacial de las mismas. Se partió de la hipótesis de que el régimen hidrológico y el patrón de paisaje son los factores principales que determinan la heterogeneidad de la región y condicionan la presencia y abundancia de las especies y comunidades vegetales. En 21 sitios de muestreo se realizaron un total de 177 censos en los que se identificaron 62 especies, se estimó la abundancia-cobertura por especie y se tomaron muestras de suelo. Se delimitaron 19 comunidades vegetales que conforman un mosaico heterogéneo, se caracterizan por su baja riqueza específica y la dominancia de unas pocas especies de tipo graminoide y en menor medida de latifoliadas. La presencia diferencial de las comunidades en la región y su composición específica se relacionó con dos factores principales de variación. El primero fue la permanencia del agua relacionado con la posición topográfica de los censos, el segundo correspondió al grado de conexión de las comunidades con los cursos de agua principales y por su localización con relación al macrogradiente de influencia fluvial-estuárica regional

  14. Substratos no enraizamento de estacas herbáceas de figueira oriundas da desbrota Substrates in the rooting of fig tree herbaceous cuttings originated from the sprouting

    Directory of Open Access Journals (Sweden)

    Rafael Pio

    2005-06-01

    Full Text Available Com o presente trabalho teve-se como objetivo verificar o enraizamento de estacas de figueira oriundas da desbrota, por meio da utilização de diferentes substratos. Foram coletadas estacas herbáceas de figueira 'Roxo de valinhos', aproximadamente com 10 cm de comprimento, no momento da desbrota da figueira. As estacas com apenas duas folhas e sem gema apical foram acondicionadas em bandejas de polipropileno, contendo diferentes substratos: casca de pinus®, vermiculita®, fibra de coco®, plantmax®, solo + esterco bovino (1:1 v/v e tropstrato® . Posteriormente, as estacas foram colocadas em casa-de-vegetação, com umidade e temperatura controlada. Após 50 dias, avaliaram-se a porcentagem de estacas enraizadas, brotadas e mortas, número de folhas e raízes emitidas da estaca. Os substratos fibra de coco® e plantmax® promoveram melhores resultados.The present work had the objective to verify the rooting of fig tree cuttings originating from sprouting, through the use of different substrates. Herbaceous cuttings were collected of 'Roxo de valinhos' fig tree with 10 cm of length when the sprouting was happening. The cuttings with two leaves and not of the apical bud to conditioned in polypropylene trays containing different substrates: casca de pinus®, vermiculita®, coconut fiber®, plantmax®, soil + cow mature(1:1 v/v and tropstrato® . The cuttings were placed at greenhouse, under humidity and temperature control. After 50 days, the rooting, sprouting and death cutting percentage, the number of leaves and roots of each cutting were evaluated. The substrates coconut fiber® and plantmax® promoted better results.

  15. Compliance and Enforcement Actions (CEA) -

    Data.gov (United States)

    Department of Transportation — Compliance and Enforcement Actions application provides process assistance / improvements for conducting investigation and enforcement activities. The Compliance and...

  16. Enxertia herbácea em Myrtaceae nativas do Rio Grande do Sul Herbaceans grafiting in native Myrtaceae on Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Daiane Silva Lattuada

    2010-12-01

    Full Text Available O objetivo deste trabalho foi testar a viabilidade da técnica de enxertia herbácea em frutíferas nativas da família Myrtaceae. O experimento foi realizado em casa de vegetação do Departamento de Horticultura e Silvicultura/ UFRGS, em Porto Alegre. Duas espécies de Myrtaceae nativas foram usadas, tanto como porta-enxerto quanto como enxerto, Eugenia uniflora (Pitangueira e E. involucrata (Cerejeira-do-rio-grande ou Cerejeira-do-mato, totalizando quatro combinações. O método de enxertia adotado foi por garfagem em fenda cheia, em ramos herbáceos, com diâmetro médio do porta-enxerto de 0,1cm, enquanto os ramos dos enxertos apresentavam diâmetro médio entre 0,08 a 0,1cm, para as duas espécies. As análises foram quinzenais e, após 70 dias, foram analisadas estatisticamente a pega e a altura média das brotações emitidas. O delineamento experimental foi o completamente casualizado, com quatro repetições, sendo cada unidade experimental composta de cinco enxertos. Os resultados indicaram pega de 60% na combinação Pitangueira-Pitangueira (porta enxerto - enxerto. As demais combinações mostraram-se ineficientes.The objective of this study was to test the viability of the technique of green grafting in natives Myrtaceae. The experiment was conducted in greenhouse conditions of the Departamento de Horticultura e Silvicultura / UFRGS, in Porto Alegre. Two species of Myrtaceae were used, as well as rootstock and as graft, Eugenia uniflora (Surinam cherry and E. involucrata (Rio-grande-cherry or Cherry of the woods, totaling four combinations. The adopted grafting method consisted to cleft the graft on herbaceous branches, with an average diameter of the rootstock of 0.1 cm, while the branches of the grafts had an average diameter between 0.08 to 0.1 cm for both species. The observations were carried out every two weeks, and after 70 days were statiscally analyzed. The experimental design was completely randomized with four

  17. Composição e distribuição dos Crustácea (Decapoda na Lagoa do Peixe, Rio Grande do Sul, Brasil Composition and distribution of Crustácea (Decapoda from Lagoa do Peixe, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Sandro Santos

    2000-03-01

    Full Text Available The Lagoa do Peixe ("Peixe's Lagoon" is located between Atlantic Ocean and Lagoa dos Patos and is 30 Km long and 0,5-2,0 Km wide (31º13'S, 50º55'W -31º26'S, 51º09'. For one year, the composition and distribution of Crustácea Decapoda were analyzed monthly (from July/1994 to June/1995, in seven subareas (terrestrial border and aquatic area and physical and chemical parameters (depth, salinity, sediment texture, oxygen in water, organic material of sediment and water temperature were registered. Decapoda from the families Grapsidae, Ocypodidae, Portunidae (Brachyura, Diogenidae (Anomura and Penaeidae (Penaeidea were captured. Chasmagnathus granulata Dana 1851 was found ali months near the canal connecting Atlantic Ocean and Lagoa do Peixe, but inside the lagoon it was collected only in October/94 and June/95, and in extreme subareas it was sampled in February/95 when the salinity was 31 ‰ at these sites. Callinectes sapidus Rathbun, 1896 and Cyrtograpsus angulatus Dana, 1851 were captured throughout the year, except October/94 and April/95, respectively. Both species were found in ali áreas of sample, indicating a high plasticity in relation to the factors analyzed in this study. Another species captured probably come in the lagoon in specific months, when the environment provides ideal conditions for their develo-pments.

  18. Fecha de aplicación de fuego y diversidad de herbáceas en una sabana de Elionorus muticus (Spreng) O. Kuntze Date of prescribed fire and herbaceous diversity of an Elionorus muticus (Spreng.) O. Kuntze savanna

    OpenAIRE

    CARLOS KUNST; SANDRA BRAVO; FABIO MOSCOVICH; JULIO HERRERA; JOSÉ GODOY; SILVIA VÉLEZ

    2003-01-01

    RESUMEN El fuego es a la vez una perturbación natural y una herramienta agropecuaria en las sabanas de Elionorus muticus (Spreng) O. Kuntze de la región chaqueña argentina. Nuestro objetivo fue evaluar el efecto de la fecha de aplicación de fuego sobre la diversidad de herbáceas de la sabana. Para ello se quemaron parcelas en cuatro fechas sucesivas, desde fines de julio hasta principios de octubre, en dos experimentos iniciados en 1993 y 1994, respectivamente. La riqueza y abundancia de espe...

  19. Evaluación de siete tipos de vegetales herbáceas cultivadas en acuaponia usando el efluente del cultivo de tilapia (Oreochromis niloticus x O. aureous) en condiciones salobres.

    OpenAIRE

    Campos Pulido, Rosa

    2013-01-01

    Los objetivos de este estudio fueron caracterizar fisicoquímicamente un efluente salobre de cultivo de tilapia en producción comercial, evaluar el crecimiento de siete especies vegetales herbáceas en acuaponia y conocer criterios para seleccionar plantas de acuerdo a las características del efluente. El diseño experimental fue completamente al azar. Los datos se analizaron mediante estadística descriptiva y análisis de varianza. Para comparar las medias de los parámetros evaluados se realizó ...

  20. Utilización de aguas regeneradas para el riego de dos especies de la familia de las mirtáceas (Myrtus Communis L. y Eugenia Myrtifolia L.

    OpenAIRE

    Acosta Motos, José Ramón

    2015-01-01

    [ESP] La investigación realizada evalúa la posibilidad de la reutilización de aguas residuales de distinta calidad, que previamente han sido depuradas (ARD), para el riego de dos especies de la familia de las Mirtáceas (Myrtus communis L. y Eugenia myrtifolia L.) empleadas con usos y fines ornamentales. Las aguas utilizadas en este trabajo tienen una composición que varía estacionalmente ya que presentan orígenes distintos, aunque tienen en común que son aguas más o menos salinas: ARD1 (CE = ...

  1. Heparinoides naturais isolados de rodofíceas (Halymenia sp. arribadas na costa cearense =Natural heparinoids isolated from Halymenia sp. (Rhodophyceaes delivery on the Ceará coast

    Directory of Open Access Journals (Sweden)

    José Ariévilo Gurgel Rodrigues

    2010-07-01

    Full Text Available A crescente carência de heparina (HEP motiva a busca por fontes alternativas de novos anticoagulantes naturais. Objetivou-se avaliar a atividade anticoagulante dos polissacarídeos sulfatados (PS isolados de uma rodofícea do gênero Halymenia, nativa do litoral cearense, Brasil. Os PS totais foram obtidos por digestões consecutivas com papaína em tampão acetato de sódio 0,1 M (pH 5,0, contendo cisteína 5 mM e EDTA 5 mM, seguidas por cromatografia de troca iônica em coluna de DEAE-celulose. As frações obtidas foram concentradas por liofilização e submetidas à eletroforese em gel de agarose a 0,5%. Os ensaios anticoagulantes foram realizados pelo tempo de tromboplastina parcial ativada (TTPA, usando-se plasma de coelho e uma curva padrão de HEP (100 UI mg-1. As extrações (53,96% mostraram diferenças marcantes durante o fracionamento e no grau de resolução dos PS. A espécie apresentou PS com atividade anticoagulante superior a HEP. O TTPA das frações modificou-se acentuadamente entre as extrações, expressando-se de maneira dose-dependente e sofrendo um acréscimo de 110,40 (1a extração para 143,10 UI mg-1 (3a extração. Os resultados sugerem que a atividadeanticoagulante dos PS isolados de Halymenia sp. foi promovida pela inibição da via intrínseca e/ou comum da cascata de coagulação. As modificações no TTPA possivelmente serão elucidadas pelos mecanismos de ação envolvidos na coagulação e caracterização estrutural desses compostos. Portanto, a rodofícea Halymenia sp. é uma boa fonte de heparinoides e sugerem-se estudos relacionados ao cultivo da espécie, em proteção aos bancos de algas.The increasing demand for heparin (HEP has led to a search for alternative sources of natural anticoagulants. This study aimed to evaluate the anticoagulant activity of sulfated polysaccharides (SP isolated from a Halymenia rhodophyceae genus native to the coast of Ceará, Brazil. Total SP were obtained by consecutive

  2. Substratos no enraizamento de estacas herbáceas de amora-preta Xavante Substrates on rooting of blackberry Xavante herbaceous cuttings

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    Lilian Yukari Yamamoto

    2013-01-01

    Full Text Available A amora-preta (Rubus spp. destaca-se entre as espécies que apresentam boas perspectivas de cultivo em áreas de agricultura familiar. Visando a otimizar a multiplicação de mudas dessa espécie, o objetivo deste trabalho foi avaliar o uso de substratos e concentrações do ácido indolbutírico (AIB no enraizamento de estacas de amora-preta Xavante. O delineamento experimental foi o inteiramente casualizado em arranjo fatorial 3x2 (três tipos de substratos e duas concentrações de AIB, com cinco repetições de sete estacas, sendo adotados os fatores: tipos de substratos (casca de arroz carbonizada, vermiculita grânulos médios e fibra de coco e tratadas ou não com AIB (0 e 1000mg L-1. Após 80 dias, foram avaliadas as variáveis: sobrevivência das estacas; retenção foliar; estacas enraizadas; número de raízes por estaca; comprimento da maior raiz; massa seca das raízes por estaca; e pH; condutividade elétrica; densidade e capacidade de retenção de água dos substratos. Não houve influência dos substratos e da aplicação de AIB sobre a porcentagem de estacas enraizadas, verificando-se alta eficiência no enraizamento das estacas de amora-preta Xavante (86,2%. Para a porcentagem de sobrevivência das estacas, o melhor resultado foi obtido sem a aplicação de AIB. Conclui-se que a amora-preta Xavante pode ser propagada por estaquia herbácea com eficiência, sem o uso de AIB, utilizando-se preferencialmente o substrato casca de arroz carbonizada como opção de baixo custo.The blackberry (Rubus spp. stands out among the species that have good prospects for cultivation in areas of family farm agriculture. In order to optimize the multiplication of seedlings of this species, the aim of this research was to evaluate the use of different substrates and concentrations of indolebutyric acid (IBA on the rooting of cuttings of blackberry Xavante. The experiment was performed using the completely randomized design in a 3x2 factorial

  3. Pityriasis amiantacea: clinical-dermatoscopic features and microscopy of hair tufts Pitiríase amiantácea: aspectos clínicos e dermatoscópicos e microscopia dos tufos capilares

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    Gustavo Costa Verardino

    2012-02-01

    Full Text Available Pityriasis Amiantacea, also known as pseudotinea amiantacea, is a clinical syndrome which affects the scalp, having a reaction pattern reported to occur in several inflammatory dermatoses. The authors seek to establish the correlation between its clinical, dermoscopic and light microscopy features through the analysis of scale- encrusted hair tufts submitted to histological processing.A pitiríase amiantácea, também chamada de pseudotínea amiantácea, é compreendida como uma síndrome clínica que acomete o couro cabeludo. Representa um padrão de reação a diversas dermatoses inflamatórias. Os autores procuram estabelecer a correlação entre características clínicas, dermatoscópicas e de microscopia ótica, através da análise do tufo de cabelos agregados pelas escamocrostas, submetido a processamento histológico.

  4. Selección de rizobacterias por su antagonismo frente a microorganismos patógenos de cucurbitáceas /Screening of rhizobacteria for their antagonism against microbial pathogens of cucurbits.

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    Gilda Jiménez Montejo

    2014-04-01

    Full Text Available Resumen:El desarrollo de inoculantes microbianos a partir de aislamientos de rizobacterias con potencial para el control biológico de enfermedades de los cultivos agrícolas requiere de una rigurosa selección. Se obtuvieron aislamientos bacterianos de la rizosfera de papa (Solanum tuberosum L. y de maíz (Zea mays L. y de semillas de frijol (Phaseolus vulgaris L.. Las colonias que mostraron in vitro halos de inhibición de los patógenos de cucurbitáceas: Xanthomonas cucurbitae, Acidovorax avenae subsp. citrull y Fusarium oxysporum, se seleccionaron como antagonistas. A partir de las características morfológicas, fisiológicas y bioquímicas las cepas antagonistas F16/95 y Xph se identificaron con la especie Bacillus subtilis y la cepa 14A como Pseudomonas putida. Las pruebas presuntivas de producción de antibiocinas in vitro sugirieron modos de acción de las rizobacterias relacionados con antibiosis y competencia por el hierro mediante la producción de sideróforos. Los resultados indicaron el potencial de las cepas de rizobacterias antagonistas Bacillus subtilis (F16/95, Xph y Pesudomonas putida 14A para el control biológico de enfermedades de las cucurbitáceas./Abstract:

  5. Propriedades físicas e tecnológicas de farinha de trigo tratada com terra diatomácea Technological and physical properties of wheat flour treated with diatomaceous earth

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    Janete Deliberali Freo

    2011-06-01

    Full Text Available Embora exista grande número de trabalhos sobre a aplicação de terra diatomácea no controle de insetos em grãos de trigo, as informações sobre o resíduo que permanece na farinha após a moagem, mesmo com retirada parcial na etapa de limpeza, e se este altera a qualidade tecnológica, são restritas. O objetivo deste estudo foi avaliar as propriedades físicas e tecnológicas de farinha de trigo tratada com diferentes terras diatomáceas. As terras diatomáceas de marcas comerciais, codificadas como TD1 e TD2 e a farinha de trigo tipo I foram adquiridas no mercado local. A TD1 e TD2 foram adicionadas nas doses zero, 0,5, 1,0 e 2,0g kg-1 de farinha de trigo, homogeneizadas em misturador e realizadas as análises número de queda, alveografia, farinografia, cor e teste de panificação experimental. O experimento foi conduzido em delineamento inteiramente casualizado em arranjo fatorial 2x4, os resultados submetidos à análise de variância (ANOVA e nos modelos significativos, as médias comparadas entre si pelo teste de Tukey a 5% de significância. A terra diatomácea adicionada na quantidade de até 2g kg-1 afeta as propriedades físicas e funcionais da farinha de trigo. O alveógrafo é efetivo para predizer alterações nas propriedades físicas de farinha de trigo tratada com terra diatomácea. As alterações mais acentuadas nas propriedades físicas da farinha de trigo são do componente L* (luminosidade de cor e força geral de glúten (W, enquanto que nas tecnológicas o escore de pontos e componente L* de cor do miolo.Although there are many studies on the application of diatomaceous earth for insect control in wheat grains, the information about the residue that remains in the flour after grinding, even with partial removal in the cleaning step, and if this changes the technological quality are restricted. The objective of this study was to evaluate the physical and functional properties of wheat flour treated with diatomaceous

  6. Fijación biológica de nitrógeno por tres fabáceas (Leguminosae en suelos ácidos de Tabasco, México

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    S. Córdova-Sánchez

    2011-01-01

    Cajanus cajan L., Canavalia ensiformis L. y Mucuna deerengiana L., en rotación y asociación con maíz durante dos ciclos de cultivo, se desarrollaron dos experimentos en un suelo ácido de la sabana de Huimanguillo, Tabasco. En ambos sistemas se evaluaron variables relacionadas con la nodulación de estas fabáceas, así como su efecto sobre el rendimiento de maíz (Zea mays L.; también se cuantificó el N derivado de la atmósfera (Fbn y la eficiencia de absorción de N por el cultivo de maíz a través de la técnica isotópica de 15N. Los resultados muestran que C. cajan L., produjo 66 a 121, C. ensiformis L., 38 a 80 y M. deerengiana L., 45 a 78 nódulos planta-1, con una ms máxima de 14, 7 y 4 g planta-1 en asociación como en rotación, respectivamente. La producción de biomasa por las fabáceas fue de 5,780 para C. cajan L., 7,037 para C. ensiformis L., y 5,284 kg ha-1 para M. deerengiana L., en asociación con maíz. El rendimiento de grano de los diferentes genotipos de maíz en rotación y asociación varió entre 580 a 642 kg ha-1 durante dos ciclos de estudio. El N fijado por estas fabáceas en rotación se considera muy bajo (2 kg N ha-1; mientras que ocurrió mayor fijación en la asociación fabaceae-maíz (135 kg N ha-1, pero la alta dosis de Fbn no repercutió en mayor rendimiento de grano respecto a los testigos.

  7. Diatomáceas epilíticas de águas oligotróficas e ácidas do Sudeste do Brasil Epilithic diatoms from acidic and oligotrophic waters in Southeast Brazil

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    Luís Gustavo de Castro Canani

    2011-03-01

    Full Text Available Poucos estudos tem abordado a flora de diatomáceas de sistemas oligotróficos do Brasil. São apresentados os resultados da composição taxonômica e distribuição espacial e temporal de diatomáceas no rio do Salto, situado no Parque Estadual do Ibitipoca, Minas Gerais (21º40'-21º44'S e 43º52'-43º55'W. As águas desse rio possuem pH entre 4,2 e 5,5 e concentração de ortofosfato entre 1,37 e 10,98 µg.L-1. O estudo baseia-se na análise de 80 amostras coletadas em oito estações no leito rochoso do rio, em janeiro e julho de 2004, períodos de chuva e estiagem, respectivamente. Um total de 15 espécies e duas variedades taxonômicas, distribuídas em oito gêneros e oito famílias foram descritas e ilustradas, com destaque para o gênero Eunotia Ehrenberg. O estudo sobre diatomáceas bentônicas em ambientes lóticos é pioneiro no estado de Minas Gerais, sendo registradas 14 novas citações, das quais Fragilariforma stevensonii Metzeltin & Lange-Bertalot, Eunotia pirarucu Metzeltin & Lange Betalot, Nupela giluwensis Vyverman & Compère e Sellaphora blackfordensis Mann & Droop são primeiros registros para o Brasil.Few studies have been done on the diatom flora of acidic and oligotrophic environments from Brazil. We present the taxonomic composition and distribution of diatoms of Salto River, situated at Ibitipoca State Park, Minas Gerais (21º40'-21º44'S; 43º52'-43º55'W. The pH values ranged from 4.2 to 5.5 and orthophosphate was between 1.37 and 10.98 µg.L-1. The study is based on the analysis of 80 samples collected at eight stations in the rocky stream bed, in January and July 2004, rainy and dry seasons, respectively. A total of 15 species and two taxonomic varieties distributed in eight genera and eight families were described and illustrated, notably the Eunotia Ehrenberg genus. The study of benthic diatoms in lotic systems is pioneer in Minas Gerais state; 14 new records were recorded of which Fragilariforma stevensonii

  8. Efeito do ácido indolbutírico e raizon no enraizamento de estacas herbáceas e lenhosas de umbuzeiro = Effect of indolbutiric acid and raizon in the rooting of herbaceous and hardwoody cuttings of umbu tree

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    Luciane Arantes de Paula

    2007-07-01

    Full Text Available O umbuzeiro pode ser propagado assexuadamente, mas poucas informações se tem de que a espécie pode ser propagada por estaquia. Diante disso, o objetivo do trabalho foi avaliar o efeito de diferentes concentrações de AIB (ácido indolbutírico e do Raizon 05® no enraizamento de estacas herbáceas e lenhosas de umbuzeiro. Utilizou-se o delineamento experimental em bloco ao acaso, com quatro concentrações de AIB (0; 500; 1000 e 2000 mg L-1 e uma de Raizon 05® e dois tipos de estacas (herbácea e lenhosa. As estacas foramtratadas com Metiltiofan (Thiophanate methyl a 0,05% i.a. por um minuto, em seguida foram imersas nas soluções de AIB por dez minutos ou em contato com Raizon 05®. Realizou-se o plantio em tubetes plásticos contendo vermiculita média. O material permaneceu em telado com 50% de redução de luz, com nebulização intermitente. As variáveis analisadas foram: porcentagem de sobrevivência, enraizamento e massa seca das raízes. Pode-se concluir que: as estacas lenhosas apresentaram melhores resultados em relação às estacas herbáceas para a sobrevivência; o maior percentual de enraizamento foi verificado em estacas herbáceas com a aplicação de 500 mg L-1 de AIB, proporcionando33,33% de estacas enraizadas.The umbu tree can be propagated assexually, but few information are had that the species can be propagation by cutting. The objective of the present research was to evaluate the effect of different concentrations of IBA (indolbutiric acid and Raizon 05® in the rooting of cuttings herbaceous and hardwoody of umbu tree. The experimental design used was block at random, with four concentrations of IBA (0; 500; 1000 and 2000 mg L-1 and one of Raizon 05® and two types of cuttings (herbaceous and hardwoody. After the treatment of the cuttings with Metiltiofan (Thiophanate methyl a 0,05% i.a. for one minute, these were immersed in the solutions of IBA by ten minutes, or in contact with Raizon 05®, soon afterwards took

  9. Is geographical rarity frequent among the cacti of the Chihuahuan Desert? ¿Es la rareza geográfica frecuente entre las cactáceas del Desierto Chihuahuense?

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    Héctor M. Hernández

    2010-04-01

    Full Text Available With the aim of assessing the extent of geographical rarity of Mexican Cactaceae, we calculated the distribution size (area of occupancy of 142 species from the Chihuahuan Desert. In addition, using 2 variables (number of localities and range size, we preliminarily assessed their conservation status using the current IUCN Red List criteria. The results showed enormous variation in the areas of occupancy, although from the biogeographic and conservation perspective the most exceptional group comprises the extremely narrow endemics (42 species, whose range is restricted to areas smaller than 10 km2. Our results reinforce the reputation of this plant family as exceptionally rare geographically. We suggest that geographical rarity of Cactaceae in the Chihuahuan Desert is a natural phenomenon; however, we propose that the range of several species has been influenced by human activities. Regarding the conservation status of the species, 75 of them are categorized as Least concern. The remaining 67 species (47.2% fall in 1 of the 3 categories of threat (27 Vulnerable, 11 Endangered, and 29 Critically endangered. These figures confirm the critical conservation status of Mexican Cactaceae.Se calculó el tamaño de la distribución (área de ocupación de 142 especies de cactáceas del Desierto Chihuahuense, con el objeto de evaluar su grado de rareza geográfica. Además, mediante el uso de 2 variables (número de localidades y tamaño de distribución, se estimó de manera preliminar su estado de conservación usando los criterios actuales de la Lista Roja de la UICN. Los resultados mostraron gran variación en las áreas de ocupación. Sin embargo, desde una perspectiva biogeográfica y de la conservación, el grupo de especies más excepcional corresponde a las endémicas restringidas (42 spp., cuyas áreas de distribución son menores de 10 km². Los resultados fortalecen la reputación de las cactáceas de ser una familia de plantas excepcionalmente

  10. Reemplazo de áreas arboladas por chaparrales y comunidades herbáceas en el período 1970-2000 en una microcuenca de Durango, México

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    Marco Antonio Márquez Linares

    2012-02-01

    Full Text Available Se realizó una comparación entre la cobertura de la vegetación existente en la microcuenca del arroyo “El Carpintero” cercana a la ciudad de Durango, México, en 1970 y 2000. Las áreas dominadas por chaparrales y por especies herbáceas aumentaron su extensión de 9 571 a 11 754 ha y de 2 188 a 6 774 ha, respectivamente, a costa de la superficie dominada por arbóreas que disminuyó de 12 952 a 6 193 ha. La tasa de deforestación anual fue de -2.43%. Las principales fuerzas que provocaron este cambio fueron: el manejo de recursos basado en la ganadería extensiva, la agricultura de temporal, la extracción de leña como principal fuente de energía y los incendios forestales.

  11. Clave para la determinación de malezas ciperáceas asociadas con el cultivo del arroz en Colombia Key for identification of cyperaceae weds associated with rice fields in Colombia

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    Fuentes Cilia Leonor

    2001-12-01

    Full Text Available Las ciperáceas constituyen, después de las gramíneas, el segundo grupo más importante de plantas adventicias asociadas
    con la producción de arroz en Colombia. Se ha podido
    observar diferencias en la respuesta a los herbicidas entre las
    especies de ciperáceas, de ahí la necesidad de reconocer las
    diferentes especies de esta familia que infestan los arrozales
    de Colombia. Se realizó una intensiva colecta botánica de estas
    especies en las principales zonas arroceras de Colombia:
    Tolima, Huila, Meta, Córdoba, Cesar, Santander y Valle del
    Cauca. Un total de 25 especies pertenecientes a nueve géneros,
    fueron reconocidas. Se elaboraron claves para la separación
    de géneros y especies.Cyperaceae constitute after the gramineous the second most
    important weed group associated with rice production in Colombia. There are sorne differences in herbicide response among cyperaceae species, therefore there is a need to recognize the different species ofthis family that infest Colombian rice fields. An intensive botanical collection of these species was done in the main rice production areas ofColombia: Tolima, Huila, Meta, Córdoba, Cesar, Santander and Valle del Cauca. A total of 25 species belonging to nine genus were identified. Keys were made to separate genera and species.

  12. Enxertia de maracujazeiro-azedo em estacas herbáceas enraizadas de espécies de passifloras nativas Grafting of passion fruit on rooted-herbaceous cuttings of wild passiflora species

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    Renata da Costa Chaves

    2004-04-01

    Full Text Available As doenças provocadas por patógenos do solo em maracujazeiro constituem-se em um dos principais problemas para essa cultura no Brasil. Uma das alternativas de controle dessas doenças seria a utilização de porta-enxertos resistentes. Várias espécies de passifloras nativas vêm apresentando resistência a essas doenças, mas a utilização destas como porta-enxertos oriundos de sementes tem sido dificultada pelas diferenças de diâmetro entre o porta-enxerto e o enxerto da espécie comercial, o que não aconteceria caso fossem utilizadas as estacas herbáceas como porta-enxerto. No presente experimento, utilizaram-se estacas herbáceas retiradas da parte mediana de ramos de plantas de Passiflora setacea (acesso EC-PS 1, P. nitida (acesso EC-PN 1, P. caerulea (acesso EC-PC 1, P. actinia (acesso EC-PA 1 e de um híbrido F1 entre P. setacea x P. edulis f. flavicarpa comercial e tratadas com ácido naftaleno acético (ANA a 500 mg/L e mantidas em câmaras de nebulização. As enxertias do tipo "garfagem lateral no topo" foram efetuadas aos 40; 55 e 70 dias após a coleta e plantio das estacas, utilizando garfos de uma única planta de maracujazeiro-azedo. As avaliações foram efetuadas aos 145 e 150 dias após o plantio das estacas, determinando-se a porcentagem de pegamento da enxertia e de enxertos brotados e o comprimento do broto do enxerto. A produção de mudas por enxertia em estacas herbáceas enraizadas de Passiflora nitida e do híbrido F1 (P. setacea x P. edulis f. flavicarpa foi tecnicamente viável.The soil born diseases cause expressive losses in passion fruit crops in Brazil. The use of resistant rootstocks is an alternative to control these diseases. Several wild species of Passifloraceae have presented resistance to soil born pathogens, but their utilization as rootstock from seeds has been limited mainly by differences of thickness between the rootstock and the graft of the commercial cultivars. These limitations could be

  13. Diatomáceas indicadoras de paleoambientes do Quaternário de Dois Irmãos, Recife, PE, Brasil Diatoms as indicators of paleoenvironments during the Quaternary at Dois Irmãos, Recife, Pernambuco State, Brazil

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    Giane Soares de Souza

    2007-09-01

    Full Text Available O trabalho apresenta o levantamento da diatomoflórula identificada em sedimentos do Quaternário da Lagoa das Diatomáceas (Dois Irmãos, Recife, baseado em um testemunho de sondagem com 4,5 m, tendo sido analisadas amostras com intervalos de 10 em 10 cm. Foram identificados 46 táxons, distribuídos em 19 gêneros, 40 espécies e seis variedades. A coluna estratigráfica esteve composta por gêneros epífitos (Actinella, Amphora, Cocconeis Eunotia, Fragilaria, Frustulia, Gomphonema e Rhopalodia, bentônicos (Navicula, Neidium, Nitzschia e Surirella e planctônicos (Aulacoseira, Cyclotella e Skeletonema. A maioria das espécies é oligoalóbia e litoral, destacando-se em termos de freqüência e abundância: Actinella brasiliensis, Anomoeoneis serians, Eunotia pectinalis, Frustulia rhomboides, sugerindo uma deposição de sedimentos em ambiente limnético. O predomínio de espécies epífitas em determinadas profundidades confirma a presença de macrófitas durante uma parte do período de deposição. Das espécies identificadas sete são consideradas de ambiente marinho: Cocconeis heteroidea, Cocconeis scutellum, Diploneis decipiens, Nitzschia scalaris, Nitzschia sigma, Skeletonema costatum e Surirella heideni as quais ocorreram de forma esporádica.A study of fossil diatoms from Lagoa das Diatomáceas (Dois Irmãos, Recife was carried out based on a 4.5-meter-long core sample. Samples were analyzed at 10 cm intervals. A total of 46 taxa were identified in 19 genera, 40 species and six varieties. The stratigraphic column was composed of epiphytic (Actinella, Amphora, Cocconeis Eunotia, Fragilaria, Frustulia, Gomphonema and Rhopalodia, benthic (Navicula, Neidium, Nitzschia, Surirella, and planktonic (Aulacoseira, Cyclotella and Skeletonema genera. Actinella brasiliensis, Anomoeoneis serians, Eunotia pectinalis and Frustulia rhomboides are oligohalobe, littoral species with high frequency and abundance, which suggests sediment deposition in a

  14. Fatores associados à rosácea em amostras populacionais do Sul do Brasil: análise de estudos casos-controles Factors associated with rosacea in population samples of Southern Brazil: analysis of case-control studies

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    Renan Rangel Bonamigo

    2008-10-01

    Full Text Available FUNDAMENTOS: A rosácea é dermatose que apresenta uma série de variáveis associadas a seu surgimento. A maioria dos estudos é proveniente dos Estados Unidos da América e de países europeus, sendo escasso o conhecimento produzido e publicado acerca da doença no Hemisfério Sul, particularmente no Brasil. OBJETIVOS: Descrever os principais fatores clínicos e histopatológicos associados à rosácea em amostras populacionais do sul do Brasil. MÉTODOS: Dois estudos casos-controles realizados em seqüência, com análise univariada e bivariada, utilizando-se p BACKGROUND: Rosacea is a dermatosis that has many factors associated with its onset. Most studies on this condition come from the United States and European countries, with little information produced and published about the disease in the Southern hemisphere, particularly in Brazil. OBJECTIVES: To describe the main clinical and histopathological factors associated with rosacea in population samples from southern Brazil. METHODS: Two case-control studies performed sequentially, with univariate and bivariate analysis, using p<0.05 for statistical significance (Chi-square test and Mantel-Haenzel, for stratifications RESULTS: Rosacea is most frequent among women and in the age range of 40-50 years. Almost all cases have phototypes II and III. The inflammatory forms of rosacea are more often diagnosed than the vascular form and there is an association with serological positivity to Helicobacter pylori and with histopathological presence of Demodex folliculorum (p<0.05. Emotional and climatic changes, exposure to the sun and intake of alcoholic beverages were the main factors described as provoking or worsening the disease. CONCLUSIONS: We have obtained an overview of rosacea in a sample of the southern population of Brazil. While some data are similar to those already described internationally, other aspects, such as economic issues and the factors described as provoking or worsening the

  15. Generation of 238U Covariance Matrices by Using the Integral Data Assimilation Technique of the CONRAD Code

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    Privas E.

    2016-01-01

    Full Text Available A new IAEA Coordinated Research Project (CRP aims to test, validate and improve the IRDF library. Among the isotopes of interest, the modelisation of the 238U capture and fission cross sections represents a challenging task. A new description of the 238U neutrons induced reactions in the fast energy range is within progress in the frame of an IAEA evaluation consortium. The Nuclear Data group of Cadarache participates in this effort utilizing the 238U spectral indices measurements and Post Irradiated Experiments (PIE carried out in the fast reactors MASURCA (CEA Cadarache and PHENIX (CEA Marcoule. Such a collection of experimental results provides reliable integral information on the (n,γ and (n,f cross sections. This paper presents the Integral Data Assimilation (IDA technique of the CONRAD code used to propagate the uncertainties of the integral data on the 238U cross sections of interest for dosimetry applications.

  16. Preferência da broca-das-cucurbitáceas [Diaphania nitidalis Cramer, 1782 (Lepidoptera: Pyralidae] por cultivares de pepineiro em ambiente protegido Pickleworm [Diaphania nitidalis Cramer, 1782 (Lepidoptera: Pyralidae]preference for cucumber cultivars in greenhouse

    Directory of Open Access Journals (Sweden)

    Giovani Greigh de Brito

    2004-04-01

    Full Text Available A broca-das-cucurbitáceas (Diaphania nitidalis é uma praga de grande importância em diversas culturas, principalmente do pepineiro. Esta espécie pode apresentar preferência em relação a determinadas cultivares quanto à sua alimentação e até mesmo oviposição. Nesse sentido, o presente estudo objetivou avaliar a ocorrência desta praga em frutos de seis cultivares de pepineiro, em ambiente protegido. As cultivares Patton, Victoria, Premier, Vlaspik e Napoleon apresentaram, respectivamente, 50%, 43,75%, 37,50%, 34,37% e 25,87% dos frutos brocados. A cultivar Marinda apresentou resultado promissor, com apenas 10,37% dos frutos com presença de larvas de D. nitidalis.The pickleworm (Diaphania nitidalis is a major pest on different crops, particulary on cucumber. This species has shown a preference for determined cultivars to its feeding and oviposition habits. Thus, the aim of this study was to evaluate the occurence of D. nitidalis larvae in fruits of six cucumber cultivars in greenhouse. The cultivars Patton, Victoria, Premier, Vlaspik and Napoleon showed, respectively, 50%, 43.75%, 37.50%, 34.37% and 25.87% of bored fruits. Promising results were obtained with the cultivar Marinda, which showed only 10.37% of bored fruits.

  17. Effect of post-weld heat treatment on microstructure, hardness and low-temperature impact toughness of electron beam welds of NIFS-HEAT-2 and CEA-J57 heats of V–4Ti–4Cr alloy

    Directory of Open Access Journals (Sweden)

    V. Tsisar

    2016-12-01

    Full Text Available Bead-on-plate electron beam welding in high vacuum atmosphere was applied to the plates of NIFS-HEAT-2 and CEA-J57 heats of V–4Ti–4Cr alloy. Effect of post-weld heat treatment (PWHT in the temperature range 673–1273K on the hardness, impact toughness at 77K and microstructure of weld metal was investigated. After PWHT at 773K, hardness of weld metal slightly decreases from 180HV100 (as-welded state to ∼170HV100 while absorbed energy increases up to ∼10J showing ductile fracture mode. PWHT at 973K results in re-hardening of weld metal up to ∼180HV100 caused by re-precipitation of Ti–C,O,N precipitates and corresponding decreasing absorbed energy to ∼2J with brittle fracture mode. PWHT in-between 1073–1273K results in gradual recovery of hardness towards values comparable with those of base metal. Impact toughness (77 K of weld metal after PWHT at 1073K is not recovered nether to the value in as-welded state nor to that one of base metal.

  18. Beyond the Space of Power. Towards a Characterization of the Scales of Action in the Territories between the Rivers Cea and Pisuerga in the 10th and 11th centuries

    Directory of Open Access Journals (Sweden)

    Álvaro Carvajal Castro

    2012-08-01

    Full Text Available The concepts of scale and scale change, as they have recently been introduced in Early Medieval historiography, have opened new ways for the historical understanding of medieval socio-spatial relations. Following this line of thought, this article reviews the concept of «space of power» in order to propose the idea of «scale of action» as a complementary analytical tool. The second part develops its use through the analysis of a region that has so far been only partially considered within the framework of studies on the territorial organization of the Duero plateau: the lands between the rivers Cea and Pisuerga and the area to its south in the 10th and 11th centuries. To do so, a selection of representative case studies will be analysed in order to identify some of the constitutive elements of the scales of action of different social agents: peasant domestic units, peasant communities, local elites, monasteries and large aristocratic groups.

  19. Enraizamento e crescimento de estacas herbáceas do cacaueiro (clones Cepec 42, tsh 516 e tsh 1188 em função da aplicação do ácido indolbutírico (AIB

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    Faria José Cláudio

    2003-01-01

    Full Text Available Estacas apicais herbáceas de ramos plagiotrópicos do cacaueiro (clones CEPEC 42, TSH 516 e TSH 1188 foram tratadas com 0 e 6.000 mg.kg-1 do ácido indolbutírico (AIB e estaqueadas em tubetes de 288 cm³ contendo como substrato uma mistura de Plantmax® e fibra de coco triturada (1:1, enriquecido com Osmocote® (19-06-20 e PG mix® (14-16-18. Os tubetes foram acondicionados em bandejas e estas foram mantidas em câmaras de nebulização. Na avaliação, realizada aos 78 dias após o estaqueamento, verificou-se que, independentemente da aplicação de AIB, as estacas dos clones avaliados apresentaram índices de enraizamento superiores a 87%, mas o tratamento das estacas com AIB aumentou os índices de sobrevivência e de estacas enraizadas de todos os clones, número de raízes (clones TSH 516 e TSH 1188, matéria seca de raízes (Clones CEPEC 42 e TSH 516 e matéria seca da parte aérea (Clones TSH 566 e TSH 1188.

  20. Diatomáceas epilíticas da subordem Sellaphorineae do rio do Monjolinho, São Carlos, SP, Brasil Epilithic diatoms of the suborder Sellaphorineae from Monjolinho River, São Carlos, São Paulo State, Brazil

    Directory of Open Access Journals (Sweden)

    Maria das Graças Machado de Souza

    2009-09-01

    Full Text Available O presente trabalho é uma contribuição ao conhecimento da biodiversidade de diatomáceas epilíticas pertencentes à subordem Sellaphorineae do rio do Monjolinho, localizado no Município de São Carlos, São Paulo. O estudo taxonômico baseou-se na análise de 33 amostras coletadas no período de maio a outubro de 1998, em seis estações de coleta previamente estabelecidas. Foram identificados 31 táxons específicos e infra-específicos dos quais 29 são citações pioneiras para o estado de São Paulo.This is a survey of epilithic diatom biodiversity of Sellaphorineae from Monjolinho river, in São Carlos district, São Paulo state. The taxonomic study was carried out based on 33 samples collected between May and October 1998 at six selected stations. Thirty one specific and infraspecific taxa were identified; twenty nine of these were recorded for the first time in São Paulo state.

  1. Diatomáceas perifíticas dos arroios Sampaio e Sampainho, Rio Grande do Sul, Brasil Periphitic diatoms from Sampaio and Sampainho streams, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Maria Angélica Oliveira

    2002-04-01

    Full Text Available Estudo taxonômico de diatomáceas perifíticas em substrato artificial (fio de poliamida foi realizado nos arroios Sampaio e Sampainho, localizados na Depressão Central do Estado do Rio Grande do Sul. A investigação baseou-se em amostragens mensais, realizadas no período de um ano (julho de 1994 a junho de 1995. Foram identificados, descritos e ilustrados vinte e um táxons infragenéricos, distribuídos em treze gêneros e onze famílias. Achnanthes rupestoides Hohn, Diadesmis brekkaensis (Petersen D. G. Mann, Navicula tenelloides Hustedt e Placoneis elginensis (Gregory E. J. Cox são registrados pela primeira vez em ambientes lóticos no Estado.Taxonomic study of periphitic diatoms on an artificial substrate (polyamide threads was undertaken in the Sampaio and Sampainho streams, that are located in the Depressão Central region of Rio Grande do Sul State. The investigation was based on monthly sampling taken from July 1994 to June 1995. Twenty one infrageneric taxa distributed in thirteen genera and eleven families were identified, described and illustrated. Achnanthes rupestoides Hohn, Diadesmis brekkaensis (Petersen D. G. Mann, Navicula tenelloides Hustedt and Placoneis elginensis (Gregory E. J. Cox are registered for the first time in lotic environments in this state.

  2. Routine monitoring of internal exposure by transuranium elements with faecal radiochemical bioassays; Surveillance systematique des expositions aux transuraniens par les analyses radiotoxicologiques des selles

    Energy Technology Data Exchange (ETDEWEB)

    Blanchin, N.; Grappin, L.; Guillermin, A.M.; Lafon, P.; Miele, A. [CEA Cadarache, Service de sante au travail, 13 - Saint-Paul-lez-Durance (France); Fottorino, R.; Ruffin, M. [CEA Cadarache, Lab. d' Analyses de Biologie Medicale, 13 - Saint-Paul-lez-Durance (France)

    2005-06-01

    The Occupational Health Service of the CEA/Cadarache is a medical unit attached to the company and is assigned to the monitoring of internal exposure of the whole staff of the site. In our specific practice of the radiological risk survey, the management of exposure to transuranium elements which concerns about 400 workers is predominant. A routine monitoring of this risk based on faecal radiochemical bioassays was set up in 2002. Herein, we present our experience over the three first years. (author)

  3. Estudio experimiental de la infiltración leucocitaria de amígdalas palatinas durante la crisis aguda de la amigdalitis pultácea en niños: Implicaciones terapéuticas sobre la modulación de la inflamación

    OpenAIRE

    Alonso Rosa, D.; López González, M.A.; Mata Maderuelo, F.; Delgado Moreno, F.

    2002-01-01

    La infección de garganta es uno de los problemas más comunes durante la infancia. El Streptococcus pyogenes está presente en la mayoría de los casos de amigdalitis pultácea. El propósito de este estudio ha sido profundizar en el conocimiento de la respuesta inmune durante la crisis aguda y el período intercrisis de la amigdalitis pultácea. Veinte niños se diagnosticaron de amigdalitis aguda recurrente (más de 4 brotes por año durante más de 1 año) con indicación de amigdalectomía con o sin...

  4. Progress in the dry route conversion process of UF-6 to UO-2: new equipment and theoretical approach; Progres dans la conversion ''voie seche' de l'hexafluorure d'uranium en poudre d'oxyde d'uranium: nouveaux moyens experimentaux et approche theorique

    Energy Technology Data Exchange (ETDEWEB)

    Perrais, C.; Ablitzer, C. [CEA Cadarache, Dept. d' Etudes des Combustibles (DEC/SPUA) 13 - Saint-Paul-lez-Durance (France)

    1999-07-01

    The dry route conversion process of UF{sub 6} to UO{sub 2} is used on a large scale to produce powder for UO{sub 2} fuel pellets. However, this powder is not very suitable for other kinds of fuels, such as for instance, Mixed Oxide (Mox) fuel. Thus, CEA and COGEMA have developed a programme to study and model the process in order to identify the parameters which lead to a better quality powder. For this purpose, specific equipment was built at the CEA/Cadarache. The first results of experiments and modelling have shown parameters which clearly modify the powder quality. (authors)

  5. Profile control studies for JET optimised shear regime

    Energy Technology Data Exchange (ETDEWEB)

    Litaudon, X.; Becoulet, A.; Eriksson, L.G.; Fuchs, V.; Huysmans, G.; How, J.; Moreau, D.; Rochard, F.; Tresset, G.; Zwingmann, W. [Association Euratom-CEA, CEA/Cadarache, Dept. de Recherches sur la Fusion Controlee, DRFC, 13 - Saint-Paul-lez-Durance (France); Bayetti, P.; Joffrin, E.; Maget, P.; Mayorat, M.L.; Mazon, D.; Sarazin, Y. [JET Abingdon, Oxfordshire (United Kingdom); Voitsekhovitch, I. [Universite de Provence, LPIIM, Aix-Marseille 1, 13 (France)

    2000-03-01

    This report summarises the profile control studies, i.e. preparation and analysis of JET Optimised Shear plasmas, carried out during the year 1999 within the framework of the Task-Agreement (RF/CEA/02) between JET and the Association Euratom-CEA/Cadarache. We report on our participation in the preparation of the JET Optimised Shear experiments together with their comprehensive analyses and the modelling. Emphasis is put on the various aspects of pressure profile control (core and edge pressure) together with detailed studies of current profile control by non-inductive means, in the prospects of achieving steady, high performance, Optimised Shear plasmas. (authors)

  6. Measurements of Thermal Power at the TRIGA Mark II Reactor in Ljubljana Using Multiple Detectors

    Science.gov (United States)

    Žerovnik, Gašper; Snoj, Luka; Trkov, Andrej; Barbot, Loïc; Fourmentel, Damien; Villard, Jean-François

    2014-10-01

    The aim of the current bilateral project between CEA Cadarache and JSI is to improve the accuracy of the online thermal power monitoring at the JSI TRIGA reactor. Simultaneously, a new wide range multichannel acquisition system for fission chambers, recently developed by CEA, is tested. In the paper, calculational and experimental power calibration methods are described. The focus is on use of multiple detectors in combination with pre-calculated and pre-measured control-rod-position-dependent correction factors to improve the reactor power reading. The system will be implemented and tested at the JSI TRIGA reactor in 2014.

  7. Fecha de aplicación de fuego y diversidad de herbáceas en una sabana de Elionorus muticus (Spreng O. Kuntze Date of prescribed fire and herbaceous diversity of an Elionorus muticus (Spreng. O. Kuntze savanna

    Directory of Open Access Journals (Sweden)

    CARLOS KUNST

    2003-03-01

    Full Text Available RESUMEN El fuego es a la vez una perturbación natural y una herramienta agropecuaria en las sabanas de Elionorus muticus (Spreng O. Kuntze de la región chaqueña argentina. Nuestro objetivo fue evaluar el efecto de la fecha de aplicación de fuego sobre la diversidad de herbáceas de la sabana. Para ello se quemaron parcelas en cuatro fechas sucesivas, desde fines de julio hasta principios de octubre, en dos experimentos iniciados en 1993 y 1994, respectivamente. La riqueza y abundancia de especies de gramíneas y latifoliadas se registraron antes del fuego; y después del mismo, al final de las tres estaciones de crecimiento siguientes. La información fue resumida en el índice de diversidad de Shannon-Wiener. Para el análisis estadístico se calculó DH', definida como la diferencia entre los índices H' antes y después del fuego. Esta variable fue sometida a un análisis de varianza, empleando la fecha de fuego, experimento, su interacción y año de observación como variables independientes, con un enfoque de medidas repetidas y en dos escalas de tiempo: a corto y largo plazo. Los resultados indican que el fuego, en general, produce un aumento de la diversidad de herbáceas. La fecha de aplicación del fuego modifica ese resultado de manera significativa, hecho que se atribuye a las condiciones ambientales de pre y post-quema específicas de cada fecha y al estado fenológico de las especies. Las fechas de fuego que causan un mayor incremento en la diversidad son agosto-septiembre, a mediados de la temporada de fuego, hecho que se atribuye a una mayor resistencia de las plantas al fuego y a las mejores condiciones climáticas post-fuego.Fire is both a natural disturbance and a range management tool in the savannas of Elionorus muticus (Spreng O. Kuntze, of the Chaco region of Argentina. Our objective was to assess the effect of different dates of fire application on the herbaceous diversity of the savanna. Plots were burn at random in

  8. Estudo da Faciologia Orgânica em Rochas Geradoras Marinhas Cretáceas do Grupo Villeta, Bacia do Valle Superior del Magdalena,Colômbia: Implicações Paleoambientais.

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    Juliana Andrade Iemini

    2007-07-01

    Full Text Available As rochas pelíticas do Cretáceo superior são asgeradoras da maior parte das reservas de petróleo naColômbia. A Bacia do Valle Superior Del Magdalena(VSM, possui afloramentos de boa qualidade e comníveis de evolução térmica, que variam desde oimaturo até o fim da “janela” de geração de óleo,tornando esta região como uma das mais propíciaspara o estudo dos processos de geração e migraçãoprimária do petróleo no Cretáceo superior. O objetivoprincipal consistiu no estudo de fácies orgânicaatravés da caracterização geoquímica e análisepalinofaciológica das rochas geradoras de petróleocretáceas do VSM numa seção aflorante (QuebradaBambuca, objetivando o entendimento do controleexercido pela evolução paleoambiental sobre opotencial gerador e as variações composicionaisda matéria orgânica a partir da integração dosdados geoquímicos e palinofaciológicos. Paratanto, foram utilizadas análises organogeoquímicas(Carbono Orgânico Total - COT e Pirólise Rock-Eval, cedidas pelo Instituto Colombiano doPetróleo ICP - ECOPETROL e palinofaciológicasem amostras das Formações Tetuan Bambuca e LaLuna, Grupo Villeta, Bacia do Valle Superior delMagdalena. As rochas dessa formação apresentamum elevado conteúdo orgânico, com valores deCOT de até 23%. As lâminas organopalinológicasforam analisadas através de técnicas de palinofácies(microscopia em luz branca transmitida e luz azul/ultravioleta incidente-fluorescência realizando acontagem dos componentes orgânicos particuladosdos grupos do querogênio (fitoclasto, palinomorfoe matéria orgânica amorfa e da determinação doÍndice de Coloração de Esporos (ICE. A analisemicroscópica revelou um predomínio de matériaorgânica amorfa. Os palinomorfos são representadospor dinoflagelados e esporomorfos, sendo osdinoflagelados os mais representativos. A matériaorgânica amorfa apresenta fluorescência amarelaa laranja. O material lenhoso representa a

  9. Organic matter quality in a soil cultivated with perennial herbaceous legumes Qualidade da matéria orgânica de um solo cultivado com leguminosas herbáceas perenes

    Directory of Open Access Journals (Sweden)

    Luciano Pasqualoto Canellas

    2004-02-01

    Full Text Available Using herbaceous legumes in agricultural systems yields great quantities of plant residues, allowing changes in soil organic matter quality and content over the years. This study was conducted on an Ultisol, at Seropédica, RJ, Brazil, to evaluate the effects of different perennial herbaceous legumes on soil organic matter quality. A factorial scheme with three replications was used to evaluate the species: forage groundnut cv. BR-14951 (Arachis pintoi, tropical kudzu (Pueraria phaseoloides, and siratro (Macroptilium atropurpureum. After the first cut, each plot was divided into two subplots; plants were cut and left on the soil surface or cut and removed. Soil samples of a closed area covered by spontaneous vegetation (mainly C3 plants or by Panicum maximum were also analysed. Samples were collected from two layers (0-5 and 5-10 cm, processed for the fractionation of organic matter and the evaluation of structural characteristics of humic acids (HA. Evaluated legumes did not change total organic carbon contents, but promoted HA accumulation in the superficial soil layer. Humic acids may be used as indicators of the management effects on soil organic fractions, because there was significant incorporation of carbon and nitrogen derived from the legume residues, even for the short experimentation time (28 months. Residue management did not modify quantitative aspects of the distribution of the humified organic matter, but promoted, however, a higher condensation degree of humic acids evaluated by the elementary composition, IR and fluorescence spectroscopy.O uso de leguminosas herbáceas em sistemas agrícolas permite o aporte de quantidades expressivas de fitomassa, possibilitando alterações no teor e na qualidade da matéria orgânica do solo ao longo dos anos. Este trabalho avalia a qualidade da matéria orgânica de um Argissolo Vermelho Amarelo localizado em Seropédica, RJ, e cultivado com diferentes espécies de leguminosas herbáceas

  10. Side Effects of Fungicides Used in Cucurbitaceous Crop on Trichogrammaatopovirilia Oatman & Platner (Hymenoptera: Trichogramatidae Efectos Secundarios sobre Trichogramma atopovirilia Oatman & Platner (Hymenoptera: Trichogramatidae de Fungicidas usados en Cucurbitáceas

    Directory of Open Access Journals (Sweden)

    Dirceu Pratissoli

    2010-06-01

    producción de cucurbitáceas en Trichogramma atopovirilia Oatman & Platner sobre huevos de D. hyalinata. Se evaluaron los fungicidas azoxystrobina (0.08 g ingrediente activo [ia] L-1, clorotalonil (2.00 g ia L-1, mancozeb (1.60 g ia L-1, tebuconazole (0.25 g ia L-1 and tiofanato-metil (0.49 g ia L-1. Tarjetas con 30 huevos de D. hyalinata previamente sumergidos en los fungicidas y en agua destilada (control fueron ofrecidas a 20 hembras de T. atopovirilia con hasta 24 h de emergencia individualizadas en tubos de vidrio. Se evaluó parasitismo, reducción de parasitismo, emergencia, proporción sexual en la población y el número de individuos emergidos por huevo. Los fungicidas clorotalonil, tiofanato-metil y tebuconazol redujeron el parasitismo de T. atopovirilia en 43,37; 27,64 y 18,51%, respectivamente. Sin embargo, el parasitismo con azoxistrobina (79,21% fue mayor que el control (67,37% (P ≤ 0,05. Clorotalonil, tiofanato-metilo y el tebuconazol redujo la aparición de 73,77, 75,62 y 79,35% (P ≤ 0,05, respectivamente. Azoxistrobina y tiofanato-metil reduciran la proporción de sexos de 0,77 y 0,76 (P ≤ 0,05, respectivamente. Ninguno de los fungicidas redujo el número de individuos por cada huevo. Los fungicidas azoxistrobina y mancozeb fueron selectivos para T. atopovirilia en la mayoría de los parámetros estudiados, por lo tanto, deberían tener prioridad en el manejo de enfermedades de cucurbitáceas para permitir el uso eficiente de los enemigos naturales de D. hyalinata.

  11. Análisis de la variabilidad genética de la colección colombiana de musáceas usando marcadores isoenzimáticos

    Directory of Open Access Journals (Sweden)

    Giraldo Martha C.

    2011-06-01

    Full Text Available La Colección Colombiana de Musãceas (CCM es la ünica a nivel mundial %ue representa un alto valor por ser la %ue posee introducciones andinas de altura (& 1( m.s.n.m.. La caracterización de este germoplasma puede generar valor agregado para su utilización en procesos de selección clonal - para el mejoramiento genético de la especie, mediante el uso de materiales diploides con características transmisibles de importancia. Por esta razón, 33 clones de la CCM conservadas in vitro, fueron evaluadas bio%uimicamente mediante 1 enzimas, de las cuales cuatro 4ueron polimór7cas: glutamato o=aloacetil transaminasa (GOT, a13-esterasa (a13HIJL, pero=idasa (PMQ - dia4orasa (DVWP. La enzima GYL 4ue la mãs discriminante entre grupos genómicos particulares. PMQ, DVWP - a13HIJL permitieron evaluar la variabilidad al interior de cada grupo. Il estudio 4acilita el entendimiento de la estructura genética de los genotipos de plátano y banano cultivados en Colombia. .

  12. Simultaneous detection of multiple mRNA markers CK19, CEA, c-Met, Her2/neu and hMAM with membrane array, an innovative technique with a great potential for breast cancer diagnosis.

    Science.gov (United States)

    Chen, Chung-Chi; Hou, Ming-Feng; Wang, Jaw-Yuan; Chang, Tsai-Wang; Lai, Dan-Yu; Chen, Yi-Fang; Hung, Sung-Yu; Lin, Shiu-Ru

    2006-08-28

    The objective of this study was mainly to develop and evaluate a membrane array-based method simultaneously detecting the expression levels of a multiple mRNA marker panel in the peripheral blood for used in complementary breast cancer diagnosis. The mRNA markers employed included cytokeratin 19 (CK-19), carcinoembryonic antigen (CEA), c-Met, Her2/neu, and mammaglobin (hMAM). The specimens of peripheral blood were collected from 80 healthy women and 102 female patients with breast cancer. The expression levels of molecular markers were evaluated by real-time Q-PCR and membrane array. Data obtained from real-time Q-PCR and membrane array were subjected to linear regression analysis, revealing that there was a high degree of correlation between the results of these two methods (r=0.979, Pmembrane array assay with a combined panel of five mRNA markers was demonstrated to achieve sensitivity of 80.6%, and specificity of 83.8% for breast cancer detection, much higher than those of analysis of single marker. In addition, we demonstrated that the membrane array method could detect circulating cancer cells at a density as low as five cancer cells per 1 ml of blood. The analysis of correlation between the outcome of membrane array and clinicopathological characteristics indicated that overexpression of the multiple marker panel was significantly correlated with tumor size (P=0.030) and TNM stage (0.009). In conclusion, the detection of circulating cancer cells by means of membrane array simultaneously monitoring five mRNA markers could significantly enhance the sensitivity and specificity for cancer cell detection.

  13. Caracterización física, morfológica y evaluación de las curvas de empastamiento de musáceas (Musa spp.

    Directory of Open Access Journals (Sweden)

    Javier Darío Hoyos-Leyva

    2012-07-01

    Full Text Available Se caracterizaron veinte variedades de musáceas de diferente composición genética: AB, BB, AAA, AAB, ABB, AAAA y AAAB, del Banco de Germoplasma existente en la hacienda Las Vegas, de Fedeplátano, Chinchiná (1360 m.s.n.m., 4° 58' N y 75° 20' O, Colombia. La caracterización incluyó propiedades físicas como peso, diámetro, longitud, materia seca y porcentaje de cáscara del fruto y propiedades funcionales como harinas y almidones. El análisis de componentes principales (ACP mostró que las variedades de plátano se diferencian por su mayor tamaño (peso, longitud y diámetro. M. B. Tani, ICAFHIA 110, Saba, y los plátanos del subgrupo Bluggoe tuvieron altos porcentajes de cáscara. Entre los demás clones no se observaron diferencian entre sí. Los plátanos de cocción del subgrupo Plantain presentaron el mayor contenido de materia seca. Bocadillo Chileno e híbridos postre (exceptuando FHIA-1, presentaron mayor contenido de fracción comestible frente a las demás variedades. La temperatura de inicio de gelatinización de las harinas en el RVA varió entre 66.58 °C para la variedad Bocadillo Chileno y 75.21 °C para Mbindi. La viscosidad máxima varió entre 441.57 y 1837.17 cP para las variedades Tafetán Rojo y Dwarf Cavendish, respectivamente. La facilidad de cocción varió entre 2.76 min en Bocadillo Chileno y 7.55 min en Gros Michel Guayabo. La temperatura de inicio de gelatinización de los almidones varió entre 65.58°C para Gros Michel Guayabo y 74.41°C en Tafetán Rojo. La variedad Yangambi Km3 presentó la viscosidad máxima a 483.24 cP e Indio a 1958.44cP. La variedad Mbindi presentó la mayor facilidad de cocción (1.91 min mientras que FHIA-1 presentó el mayor tiempo (9.49 min.

  14. Efeito de extratos aquosos de meliáceas sobre Bemisia tabaci biótipo B em tomateiro Effect of aqueous extracts of meliaceous plants on Bemisia tabaci B biotype on tomato plants

    Directory of Open Access Journals (Sweden)

    ANTONIO PANCRÁCIO DE SOUZA

    2000-01-01

    Full Text Available Comparou-se a bioatividade de extratos aquosos a 3% (p/v de três meliáceas, Melia azedarach L. (frutos verdes, Trichilia pallida Swartz (ramos e Azadirachta indica A. Juss (sementes, em relação à mosca branca Bemisia tabaci (Gennadius biótipo B, criada em tomateiro. No primeiro experimento os extratos foram aplicados sobre ovos e sobre ninfas com três dias de idade, avaliando-se a mortalidade e a duração das fases de ovo e de ninfa. No segundo experimento os extratos foram aplicados apenas sobre as ninfas, avaliando-se a mortalidade nessa fase e a longevidade e fecundidade dos adultos. Em relação à fase de ovo, o extrato de T. pallida foi o que provocou maior mortalidade, seguindo-se os de A. indica e M. azedarach. A maior mortalidade ninfal foi constatada com o extrato de A. indica, seguindo-se os de T. pallida e M. azedarach. Nenhum dos extratos afetou a duração das fases de ovo e de ninfa, assim como a longevidade e fecundidade.The objective of this research was to compare the effect of aqueous extracts of fresh fruits of Melia azedarach L., twigs of Trichilia pallida Swartz and seeds of zadirachta indica A. Juss, on eggs and nymphs of silverleaf whitefly Bemisia tabaci (Gennadius B biotype reared on tomato plants. The extracts were tested at a concentration of 3%. In the first experiment, the extracts were applied on eggs and 3-day-old nymphs. Records were taken on mortality, duration of egg and nymphal stages. In the second experiment the extracts were applied on 3-day-old nymphs and records were taken on nymphal mortality, adult longevity and fecundity. The extracts of T. pallida were the most effective on eggs, followed by A. indica and M. azedarach. The extracts of A. indica were the most effective on nymphs followed by T. pallida and M. azedarach. In both experiments, the duration of egg and nymph stages, longevity and fecundity were not affected by the extracts.

  15. Fenologia da floração e frutificação de mirtáceas nativas da floresta com araucária Phenology of blooming and fruiting of myrtaceae native species of araucaria forest

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    Moeses Andrigo Danner

    2010-03-01

    Full Text Available Estudos de fenologia são importantes para definição de vários tratos culturais de espécies frutíferas. Assim, estudou-se a fenologia da floração e da frutificação de mirtáceas nativas da Floresta com Araucária, na região sudoeste do Paraná. Foram feitas observações fenológicas em pitangueira, cerejeira-do-mato, uvalheira, guabirobeira e araçazeiro, de julho de 2007 a fevereiro de 2008, em três plantas por espécie. Foram determinadas as curvas de crescimento dos frutos com base nos seus valores de massa da matéria seca, em duas avaliações semanais. A floração das espécies ocorreu entre o final de agosto e o início de novembro. A cerejeira-do-mato é a espécie mais precoce (ciclo de 43 dias, com maturação dos frutos entre meados e fim de outubro, enquanto o araçazeiro apresenta ciclo reprodutivo mais longo (98 dias, com maturação durante o mês de fevereiro. Há diferenças no comportamento do acúmulo de matéria seca nos frutos entre genótipos da mesma espécie.Studies of phenology are important for the development of various cultural treatments of fruit species. Therefore, it was studied the phenology of blooming and fruiting of Myrtaceae native species of Araucaria Forest, in the Southwest of Paraná state, Brazil. Observations about phenology of Eugenia uniflora, Eugenia involucrata, Eugenia pyriformis, Campomanesia xantocarpa, and Psidium cattleyanum were conducted from July 2007 to February 2008, in three plants of each species. There to manufacture the curves of the fruits growth based in mass of dry matter, in two weekly ratings. The flowering of species occurred between late August and early November. The Eugenia involucrata is the earliest (cycle of 43 days, with ripening between mid and end of October, while the Psidium cattleyanum presents reproductive cycle longer (98 days, with maturity during the month of February. There are differences in behavior accumulation of mass of dry matter between

  16. Diatomaceous earth effects on weevils with different susceptibility standard to phosphine Efeito da terra de diatomácea sobre carunchos com diferentes padrões de susceptibilidade à fosfina

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    Patrícia M. da Conceição

    2012-01-01

    Full Text Available The aim of this study was to evaluate the insecticide activity of diatomaceous earth (DE, at different temperatures, on two populations of Tribolium castaneum and Rhyzopertha dominica previously diagnosed as resistant and susceptible to phosphine. The efficiency of DE in the control of the insects was evaluated at temperatures of 20, 25, 30, 35 and 40 ± 2 ºC. The experiments were accomplished in Petri dishes containing 35 g of whole-wheat grain treated with DE in the dose of 1.0 kg t-1. The control was constituted by untreated wheat grain. Each Petri dish was infested with 30 adult insects. Insect mortality was registered seven days after the beginning of the bioassays. The experiment was conducted in a completely randomized design with three replications. The populations of T. castaneum and R. dominica, respectively, resistant and susceptible to phosphine have similar susceptibility patterns. The mortality of two populations of T. castaneum increased with increasing temperature. For R. dominica, the mortality did not change with the temperature.O objetivo deste trabalho foi avaliar a atividade inseticida da terra de diatomácea (TD, em diferentes temperaturas, em relação a duas populações de Tribolium castaneum e Rhyzopertha dominica previamente diagnosticadas como resistentes e susceptíveis à fosfina. A eficiência da TD foi avaliada nas temperaturas de 20, 25, 30, 35 e 40 ± 2 ºC e os experimentos foram realizados em placas de Petri contendo 35 g de grãos inteiros de trigo, tratados com TD na dose de 1,0 kg t-1. O controle foi constituído de grãos de trigo não tratados; ressalta-se que cada placa de Petri foi infestada com 30 insetos adultos, cuja mortalidade foi contabilizada sete dias após o início dos bioensaios. O delineamento experimental utilizado foi o inteiramente casualizado, com três repetições. As populações de T. castaneum e R. dominica, respectivamente, resistentes e susceptíveis à fosfina apresentaram padr

  17. Avaliação da adsorção de Fenol e Bisfenol A em carvões ativados comerciais de diferentes matrizes carbonáceas

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    Carla Rênes de Alencar Machado

    2015-11-01

    Full Text Available A remoção de compostos orgânicos tóxicos e micropoluentes orgânicos, provenientes de efluentes industriais, é uma crescente preocupação a fim de aumentar a qualidade da água para reúso. Para alcançar tal qualidade, alguns tratamentos têm se mostrado eficientes, tais como a adsorção em carvão ativado. Assim, o presente estudo avaliou a adsorção de fenol e bisfenol A (BPA em carvões ativados comerciais de diferentes matrizes carbonáceas: betuminosa (CB e vegetal (CV. Os carvões foram caracterizados por microscopia eletrônica de varredura (MEV acoplada ao espectro de energia dispersiva (EDS, infravermelho (FTIR e área superficial BET (Brunauer, Emmett, Teller. Foram realizados ensaios para definição de tempo de equilíbrio e ensaios para ajuste de isotermas de adsorção (Freundlich e Langmuir. A adsorção de fenol pelos dois tipos de carvões mostrou-se favorável, com remoção de 96% para o carvão CB e 91% para o carvão CV. No entanto, a adsorção de bisfenol A foi eficiente apenas para o carvão CB, com eficiências de remoção em torno de 90% contra 20% alcançado pelo carvão CV. As capacidades adsortivas encontradas para o carvão CB foram de 125 mg fenol.g-1 e 76 mg BPA.g-1, enquanto que para o carvão CV foram 99 mg fenol.g-1 e 27 mg BPA.g-1. Esses resultados estão associados à maior presença de grupos ácidos no carvão CV e à hidrofobicidade do BPA, o que torna o processo de adsorção desfavorável.

  18. Selección de leguminosas herbáceas para el fomento de cobertura en plantaciones de naranja Valencia late Selection of herbaceous legumes for the development of cover in Valencia late orange plantations

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    Dayamí Fontes

    2009-03-01

    Full Text Available El establecimiento de leguminosas herbáceas dentro de las áreas de frutales precisa de estudios que demuestren la compatibilidad de estas asociaciones, con vista a mejorar la producción en estos agroecosistemas. El objetivo del presente trabajo fue seleccionar la especie leguminosa más adecuada para emplearla como cobertura viva en plantaciones de naranja Valencia late, sobre la base de su caracterización morfoagronómica. El estudio se realizó en áreas de la Empresa de Cítricos Ciego de Ávila. Para ello se establecieron parcelas de 3 m2, sobre un suelo Ferralítico Rojo compactado, donde no se había aplicado fertilizantes ni herbicidas. Se utilizaron 14 tratamientos y se midieron los siguientes indicadores: emergencia (a los 7, 14, 21, 28 y 35 días después de la siembra en cada parcela, altura (cm, cobertura foliar (% y producción de semillas (t ha-1. De acuerdo con los resultados, Teramnus labialis fue la especie más adecuada para usarla como cobertura viva en plantaciones citrícolas, en correspondencia con el porcentaje de emergencia, el área cubierta, la altura estacional y la producción de semilla alcanzada durante el proceso de evaluación, por lo que se recomienda su utilización en los ecosistemas citrícolas de naranja V. late de Ciego de Ávila.The establishment of herbaceous legumes within fruit tree areas requires studies that prove the compatibility of these associations, aiming at improving production in these agroecosystems. The objective of this work was to select the most adequate legume species to be used as live cover in Valencia late orange plantations, based on their morphoagronomic characterization. The study was conducted in areas of the Ciego de Ávila Citrus Fruit Enterprise. For such purpose 3 m2 plots were established on a compacted Ferralitic Red soil, where neither fertilizers nor herbicides had been applied. Fourteen treatments were used and the following indicators were measured: emergence (7, 14

  19. Análise da estrutura da comunidade de diatomáceas (Bacillariophyceae em duas estações do sistema Guaíba, Rio Grande do Sul, Brasil

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    Eduardo A Lobo

    1987-12-01

    Full Text Available Através da análise da composição específica e da diversidade da comunidade de diatomáceas, em duas estações do sistema Guaíba (RS, Brasil, nos meses de setembro e novembro de 1975, foi encontrada uma diferença significativa na estrutura dessa comunidade. Essa diferença deve-se, provavelmente, à presença exclusiva de Achnanthes inflata (Kütz. Grun. var. elata (Leud. - Fort.Hust., A. lanceolata (Bréb.Grun. var. lanceolata, Cocconeis placentula Ehr., Cyclotella meneghiniana Kütz., Cymbella minuta Hilse ex Rabh., Aulacosira distans (Ehr. Sim., Navicula mutica Kütz., Surirella robusta Ehr. var. splendida (Ehr. Van Heurck, Synedra ulna (Nitz.Ehr., espécies abundantes, que refletem características ambientais distintas, pelo fato de apresentarem uma diferenciação em suas tolerâncias ecológicas. Foram identificados um total de 114 táxons, 57 a níveis específicos e infra-específicos, dentre os quais 14 constituem-se em primeira referência para o Guaíba e quatro são citações novas para o Estado.Through the analysis of specific composition and diversity of diatom community, in two sampling areas of the Guaíba system (RS, Brasil in September and October 1975, a meaningful difference in the structure of that community was found. Such difference is probably due to exclusive presence of Achnanthes inflata (Kütz.Grun. var. elata (Leud. - Fort.Hust., A. lanceolata(Bréb.Grun. var. lanceolata, Cocconeis placentula Ehr., Cyclotella meneghiniana Kütz., Cymbella minuta Hilse ex Rabh., and of Aulacosira distans(Ehr. Sim., Navicula mutica Kütz., Surirella robusta Ehr. var. splendida (Ehr.Van Heurck, Synedra ulna(Nitz.Ehr., abundant species which reflect different environmental characteristics because of their different ecological tolerances. A total of 114 taxa have been identified; 57 of them to specific and infraespecific levels, 14 of which mentioned for the first time in the Guaíba system and 4 for the first time in the state.

  20. Enraizamento de estacas lenhosas e herbáceas de cultivares de caquizeiro com diferentes concentrações de ácido indolbutírico Rooting of hardwood and herbaceous cuttings of japanese persimmon tree cultivars treated with different concentration of indolbutyric acid

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    Débora Costa Bastos

    2005-04-01

    Full Text Available Desenvolveu-se este trabalho com o objetivo de estudar a capacidade de enraizamento de estacas lenhosas e herbáceas de cultivares de caquizeiro tratadas com AIB. Estacas lenhosas e herbáceas foram coletadas de ramos de caquizeiro das cultivares Pomelo, Rama Forte, Taubaté, Giombo e Fuyu e submetidas à aplicação de AIB (0; 3.000 e 6.000 mg.L-1 por vinte segundos. Em seguida, as estacas foram colocadas em canteiro contendo uma mistura de terra + esterco de curral (3:1 v/v como substrato (estacas lenhosas e em bandejas de poliestireno expandido, contendo vermiculita média, em câmara de nebulização intermitente (estacas herbáceas. Como conclusão, observou-se que as cultivares de caquizeiro apresentam diferenças quanto ao potencial de formação de raízes e brotações; estacas herbáceas apresentam maior tendência na propagação via estaquia em comparação às estacas lenhosas.This work was carried out with the objective to study the capacity of rooting of hardwood and herbaceous cuttings of Japanese persimmon tree cultivars treated with IBA. Hardwood and herbaceous cuttings were collected from branches of Japanese persimmon tree and submitted to treatments in function of cultivars (Pomelo, Rama Forte, Taubaté, Giombo and Fuyu and of application of IBA (0, 3,000 and 6,000 mg.L-1 for twenty seconds. Later the cuttings were placed in stonemason containing a soil mixture + corral manure (3:1 v/v as substrate (hardwood cuttings and in polyethylene trays containing vermiculite as substrate, in intermittent mist chamber (herbaceous cuttings. As conclusion is observed that the cultivars of Japanese persimmon tree present differences in relationship to potential of roots and shoots formation; herbaceous cuttings present higher tendency in the propagation through cutting in comparison with the hardwood cuttings.

  1. Cuéntame un cuento, homeopatía. Desarrollo de una herramienta didáctica sobre la materia médica de un grupo de solanáceas comúnmente utilizadas en Homeopatía

    OpenAIRE

    Cepeda Romero, Julie Catherine

    2013-01-01

    Este trabajo de tesis es requisito parcial para optar al título de Magister en Homeopatía de la Universidad Nacional de Colombia. Bajo la modalidad de producto para docencia y pedagogía, esta tesis suple en parte la necesidad de material didáctico para el aprendizaje de la Homeopatía. Desde la óptica del constructivismo pedagógico, se desarrolla la materia médica de seis solanáceas comúnmente utilizadas como materia prima en la elaboración de seis remedios homeopáticos: Atropa bellad...

  2. Mortalidade do ácaro predador Neoseiulus californicus (Acari: Phytoseiidae em testes de toxicidade residual de inseticidas e acaricidas usuais em pomáceas Mortality of predatory mite Neoseiulus californicus (Acari: Phytoseiidae in residual toxicity persistence tests

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    Marcelo Gustavo Ruiz

    2008-12-01

    Full Text Available Os ácaros fitoseídeos, especialmente Neoseiulus californicus (McGregor, são importantes agentes de controle biológico de ácaros tetraniquídeos-praga nas culturas de pomáceas no "Alto Valle del Río Negro y Neuquén", Argentina. Neste trabalho, avaliou-se a mortalidade de N. californicus quando exposto a resíduos dos inseticidas azimphos-methyl, carbaryl e cyfluthrin, e dos acaricidas cyhexatin e propargite. Os produtos foram aplicados às concentrações recomendadas em plantas de pereira. Um, três, seis e dez dias após a aplicação (DAA, folhas tratadas foram retiradas das plantas para a preparação de unidades experimentais. Cinco adultos de N. californicus, provenientes de criação-estoque, foram transferidos para cada unidade, onde pólen de taboa foi fornecido como alimento. As unidades foram mantidas a 25 ± 2 ºC, 60 ± 10% de umidade relativa e fotoperíodo de 14 h. A mortalidade do ácaro foi avaliada 24 h após o confinamento. As médias de mortalidade foram comparadas pelo teste de Dunnett, a 5% de probabilidade. A progressão do declínio do efeito dos produtos testados foi submetida à análise de regressão. Nas duas primeiras datas de avaliação, todos os produtos apresentaram valores de mortalidade significativamente diferentes da testemunha tratada com água. Seis dias após a aplicação, propargite, cyhexatin e cyfluthrin apresentaram mortalidade de aproximadamente 30%, enquanto a mortalidade nos tratamentos azimphos-methyl e carbaryl apresentou níveis estatisticamente similares aos da testemunha. Dez dias após a aplicação, a mortalidade em todos os tratamentos não diferiu significativamente da testemunha. O efeito de todos os produtos apresentou declínio progressivo ao longo do período de observação, sendo significativa a 1% de probabilidade a regressão linear negativa para os valores obtidos. Os maiores efeitos negativos sobre a sobrevivência de N. californicus corresponderam aos acaricidas testados

  3. Education and training in the field of nuclear instrumentation and measurement: CEA/INSTN (National Institute for Nuclear Sciences and Technologies) strategy to improve and develop new pedagogical tools and methods

    Energy Technology Data Exchange (ETDEWEB)

    Vitart, Xavier; Foulon, Francois; Bodineau, Jean Christophe; Lescop, Bernard; Massiot, Philippe [CEA/INSTN Centre des Saclay 91191 Gif sur Yvette (France)

    2015-07-01

    Part of the French Alternative Energies and Atomic Energy Commission (CEA), the National Institute for Nuclear Science and Technology (INSTN) is a higher education institution whose mission is to provide students and professionals a high level of scientific and technological qualification in all disciplines related to nuclear energy applications. In this frame, INSTN carries out education and training (E and T) programs in nuclear instrumentation and radioprotection. Its strategy has always been to complete theoretical courses by training courses and laboratory works carried out on an extensive range of training tools that includes a large panel of nuclear instrumentation as well as software applications. Since its creation in 1956, the INSTN has conducted both education and vocational programs on ionizing radiation detection. An extensive range of techniques have commonly been used during practical works with students and employees of companies who need to get the knowledge and specialization in this field. Today, the INSTN is mainly equipped with usual detectors and electronics in large numbers in order to be able to accommodate up to 48 trainees at the same time in two classrooms, with only two trainees for one workstation in order to optimize their learning. In the field of the neutron detection systems, the INSTN has strongly developed its offer taking advantage of the use of research reactors, such as ISIS reactor (700 kW) at Saclay. The implementation of neutron detection systems specific to the courses offers a unique way of observing and analysing the signal coming from neutron detectors, as well as learning how to set the parameters of the detection system in real conditions. Providing the trainees with an extensive overview of each part of the neutron monitoring instrumentation apply to a nuclear reactor, hands-on measurements on the ISIS reactor play a major role in ensuring a practical and comprehensive understanding of the neutron detection system and

  4. Rhizobia amylase production using various starchy substances as carbon substrates Produção de amilase por rizóbios, usando várias substâncias amiláceas como substratos de carbono

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    Arlem Nascimento de Oliveira

    2007-06-01

    Full Text Available Six isolates of indigenous rhizobia of Central Amazonia were screened for the production of amylases in liquid media using various starchy substances as carbon sources. All rhizobia strains could produce more extracellular protein, biomass and amylases with the different kinds of carbon substrates. Among the carbon sources tested maltose was the best substrate for protein and amylase production. In general, peach palm flour and corn starch (maizena® were also considered to be good carbon sources for rhizobia amylases. On the other hand, the biomass production by the rhizobia isolates was higher in the presence of oat flour. INPA strain R-926 was a good amylase producer in maltose (1.94 U and corn starch (0.53 U media. INPA strain R-991 was also a good amylase producer in maltose (1.66 U and corn starch (1.59 U yielding significant extracellular amylase. Correlation analysis showed significant and positive relationships between rhizobia amylases and final pH (r = 0.49, P Seis isolados de rizobia nativos da Amazonia Central foram selecionados para a produção de amilases em meio de cultura líquido, usando várias substâncias amiláceas como fontes de carbono. Os resultados mostraram que todos os isolados de rizobia podem produzir quantidades diferenciadas de proteína extracelular, biomassa e amilases com diferentes tipos de fontes de carbono. Entre as fontes testadas, maltose foi a melhor para as produções de proteína e amilase. Por outro lado, a produção de biomassa pelos isolados de rizobia foi maior na presença de farinha de aveia. O isolado INPA R-926 mostrou-se um bom produtor de amilase nos meios com maltose (1,94 U e amido de milho (0,53 U. O isolado INPA R-991 também foi um bom produtor de amilase com rendimentos significativos na presença de maltose (1,66 U e amido de milho (1,59 U. As análises de correlação revelaram relações positivas e significativas entre as atividades de amilase e pH final (r = 0,49, P < 0,05, prote

  5. Bromatologic composition of the herbaceous species of the Northeastern Brazil Caatinga Composição bromatológica de espécies herbáceas da caatinga

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    D.S. Silva

    2011-04-01

    Full Text Available The objective of this work was to evaluate the chemical composition of the pool and of four species of caatinga herbaceous vegetation in the rainy and dry seasons. The experiment was conducted in three selected shrub areas at different levels of conservation. Four samples of each species (Arachis pintoi, Boerhavia diffusa, Heliotropium ternatum, Aristida adscensionis were collected in each area and from a pool of species for determination of bromatologic composition. In the dry season, only the pool of species and the grass Aristida adscensionis were evaluated. There was a significant effect of the studied area on the chemical composition of all analyzed species. The nutrient content found in the dry matter (DM and the digestibility of the pool of species indicate that caatinga herbs presented improved quality in the rainy season. The qualitative variables of the studied species were most heterogeneous due to the variability found in caatinga. Conservation conditions in caatinga and season of the year influence bromatologic composition of the species Arachis pintoi, Boerhavia diffusa L., Heliotropium ternatum Vahl. Aristida adscensionis L. and of a pool of typical species found in Caatinga.Com o objetivo de avaliar a composição bromatológica do pool e de quatro espécies da vegetação herbácea da caatinga nos períodos chuvoso e seco foi conduzido um experimento em três áreas selecionadas de caatinga, com níveis diferenciados de conservação. Em cada área, foram colhidas quatro amostras de cada espécie (Arachis pintoi, Boerhavia diffusa, Heliotropium ternatum, Aristida adscensionis e de um pool de espécies, para determinação da composição bromatológica. Na época seca foram avaliados somente o pool de espécies e a gramínea Aristida adscensionis. Houve efeito significativo da área amostrada na composição bromatológica de todas as espécies analisadas. Os teores de nutrientes na matéria seca (MS e a digestibilidade do pool

  6. Efeitos da terra diatomácea sobre Diabrotica speciosa (Germar, 1824 (Coleoptera: Chrysomelidae em batata inglesa Effects of diatomaceous earth on Diabrotica speciosa (Germar, 1824 (Coleoptera: Chrysomelidae in potato

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    Franscinely Aparecida Assis

    2011-06-01

    Full Text Available A espécie Diabrotica speciosa é um crisomelídeo responsável por causar danos consideráveis à batateira, o que torna indispensável seu controle com inseticidas para minimizar os prejuízos causados à cultura. Assim, objetivou-se, com este trabalho, avaliar os efeitos da terra diatomácea sobre o comportamento alimentar e a mortalidade de D. speciosa em batata inglesa em condições de laboratório. Adotou-se o DIC com três tratamentos e oito repetições, sendo: 1 - testemunha; 2 - TD polvilhada (0,5 g/vaso e 3 - TD pulverizada a 1%. As batateiras, cv. Emeraude, foram polvilhadas ou pulverizadas com TD, 30 dias após o plantio e, 24 horas após a aplicação, as plantas foram fornecidas aos insetos, sem e com chance de escolha. Houve diferença significativa entre os tratamentos, sendo a menor porcentagem de folíolos com injúrias observada em plantas que receberam a aplicação de TD pulverizada (teste sem chance de escolha e TD polvilhada ou pulverizada (teste com chance de escolha. Também houve redução do número de injúrias foliares às 24 e às 48 horas (TD polvilhada ou pulverizada e, às 72 horas, a redução foi observada somente com a aplicação da TD polvilhada. Com relação à ação inseticida da TD, foi verificado seu efeito após 48 horas, tanto via polvilhamento, quanto via pulverização. Assim, a aplicação de TD pode auxiliar no manejo de D. speciosa, contribuindo para conferir proteção às plantas de batata inglesa e aumentar a mortalidade desse inseto-praga.The species D. speciosa is a chrysomelid responsible for causing considerable damage on potato plant, making its control with insecticides essential to minimize the damage caused to this culture. The objective of this study was to evaluate the effects of diatomaceous earth (DE on feeding behavior and mortality of D. speciosa in potato under laboratory conditions. A completely randomized design was used with three treatments and eight replicates being: 1

  7. Enraizamento de estacas herbáceas do porta-enxerto de videira 'Riparia de Traviú' tratadas com auxinas Rooting of herbaceous cuttings of the grape rootstock 'Riparia de Traviú' treated with auxinas

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    Fabíola Villa

    2003-12-01

    Full Text Available Estudou-se o efeito do ácido indol-butírico (AIB e ácido naftalenoacético (ANA no enraizamento de estacas do porta-enxerto de videira 'Riparia de Traviú', resultantes da desbrota realizada em plantas situadas no local definitivo, antes de serem enxertadas, visando à obtenção antecipada de novos porta-enxertos. O experimento foi conduzido em casa-de-vegetação com 50% de sombrite, temperatura e nebulização controladas, no pomar didático da Universidade Federal de Lavras - UFLA. As estacas herbáceas desprovidas de folhas e com comprimento de 15 cm e 8 mm de diâmetro foram imersas em soluções AIB e ANA (0, 1000, 2000, 3000 e 4000 mg.L-1 por 15 segundos e, em seguida, colocadas em bandejas de isopor preenchidas com substrato vermiculita. Após 60 dias, coletaram-se os seguintes dados biométricos: porcentagem de estacas enraizadas e brotadas, número de folhas e brotos, comprimento médio das raízes e biomassa seca das brotações. Não houve efeito significativo das concentrações AIB e ANA para todas as características analisadas. Para a característica porcentagem de estacas enraizadas, obtiveram-se 56,73% de enraizamento sem aplicação de auxinas, podendo esse método resultar na antecipação da obtenção de novos porta-enxertos, utilizando-se material resultante da desbrota.The effect of the indol butiric acid (IBA and the naftalenoacetic acid (NAA in the rooting of 'Riparia de Traviú' cuttings obtained from the sproutings of the plants, before being grafted, in order to obtain new rootstocks. The experiment was conduted under green house conditions, at the orchard of the Lavras Federal University (UFLA. The herbaceous cuttings, measuring 15 cm of lengh 8 mm of diameter and without leaves, were treated with IBA and NAA (0, 1000, 2000, 3000 and 4000 mg.L-1 for 15 seconds and taken to polystyrene trays filled with vermiculita. After 60 days, the percentage of rooting and sprouted cuttings, the number of leaves and sprouts

  8. Catálogo florístico y claves de identificación de las ciperáceas de los Estados de Paraíba y Pernambuco (nordeste de Brasil

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    Luceño, Modesto

    1997-06-01

    Full Text Available The present work presents the results of our studies of the family Cyperaceae in the northeastern Brazilian States of Pernambuco and Paraiba. The introduction includes a historical synopsis of previous work and summarizes the main types of vegetation found in the región. Keys for identification of the 22 genera and 127 species which comprise the catalogue are included. The species are enumerated for each genus, along with synonyms which have been employed in the región, material examined, frequency, habitat, general geographic distribution, and taxonomic observations where appropriate. More than half of the species are new records for Pernambuco and Paraiba. Two species are reported as new to science. Fuirena lainzii Luceño & M. Alves (1996 and Scleria pernambucana Luceño & M. Alves (1997. Two species are first reports from the American continent, Pycreus pumilus (L. Nees and P. pelophilus (Ridley C.B. Clarke, and two are first repoits for Brazil, Kyllinga nemoralis (J.R. Forster & G. Forster Dandy ex Hutchinson & Daziel and Scleria mexicana (Liebm. Boeck. Six genera and 10 species are new citations for the northeastem región of Brazil. A lectotype for Cyperus grossianus T.M. Ped. is chosen. Additionally, new localities are given for regional endemisms considered for be rare; other findings represent disjunctions of considerable biogeographical importance.En el presente trabajo se exponen los resultados de las investigaciones que hemos llevado a cabo, sobre la familia de las Ciperáceas, en los Estados brasileños de Pemambuco y Paraíba. En la introducción se presenta una sinopsis histórica de los trabajos anteriores y se resumen las principales formaciones vegetales. Se ofrecen claves para la identificación de los 22 géneros y las 136 especies que componen el catálogo. Tras las claves de cada género se enumeran las diversas especies del mismo, junto con los sinónimos que han sido empleados en la región, materiales examinados

  9. Leguminosas herbáceas perenes para utilização como coberturas permanentes de solo na Caatinga Mineira Perennial herbaceous legumes used as permanent cover cropping in the Caatinga Mineira

    Directory of Open Access Journals (Sweden)

    Ricardo Borges Teodoro

    2011-06-01

    Full Text Available O presente trabalho objetivou avaliar o comportamento e as potencialidades de leguminosas herbáceas perenes para o uso como cobertura permanente em solos da região da Caatinga Mineira, Médio Vale do Jequitinhonha, MG, visando a introdução dessas plantas de cobertura em áreas agrícolas. O experimento foi conduzido de dezembro de 2008 a julho de 2009. O delineamento experimental foi em blocos ao acaso, com seis tratamentos e quatro repetições. Os tratamentos foram constituídos pelas leguminosas: cudzu tropical (Pueraria phaseoloides, calopogônio (Calopogonium mucunoides, amendoim forrageiro (Arachis pintoi, soja perene (Glycine wightii, estilosantes (Stylosanthes capitata, Stylosanthes macrocephala e pela testemunha (sem a presença de leguminosa. Foram avaliados os seguintes parâmetros: emergência das plântulas; taxa de cobertura do solo; promoção da retenção de umidade e temperatura do solo; capacidade de inibição da vegetação espontânea; potencial de deposição de folhas e de aporte de macronutrientes pela senescência de folhas; produção total de fitomassa seca e acúmulo de macronutrientes na parte aérea. A cobertura plena do solo foi alcançada pelo calopogônio, amendoim forrageiro e cudzu tropical. O calopogônio conferiu maior capacidade de retenção da umidade e inibição das plantas espontâneas. Em todos os tratamentos com leguminosas a temperatura do solo foi inferior à testemunha, a partir dos 120 dias de ciclo. Na região da Caatinga Mineira, as leguminosas perenes calopogônio e cudzu tropical, podem contribuir significativamente para o incremento de nitrogênio, aporte de outros macronutrientes (K, P, Ca e Mg e incremento da matéria orgânica do solo.The study objective was to evaluate the performance and potential of perennial herbaceous legumes for use as permanent soil cover in the Caatinga Mineira region MG, Brazil, for the introduction of these cover crops in agricultural areas. The experimental

  10. An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: III. Expressions of EMA, CEA, CA19-9, CDX-2, p53, Ki-67 antigen, TTF-1, vimentin, and p63 in normal mucosa and in 42 cases.

    Science.gov (United States)

    Terada, Tadashi

    2013-01-01

    There have no comprehensive immunohistochemical studies of primary signet ring cell carcinoma (SRCC) in the stomach and colorectum. The author examined the expression of nine common antigens (EMA, CEA, CA19-9, CDX-2, p53, Ki-67 antigen, TTF-1, vimentin, and p63) in the non-tumorous normal epithelium of the stomach and colorectum and in 42 cases of primary SRCC of the stomach (30 cases) and colorectum (12 cases). The normal epithelium of the stomach and colon consistently (100%) expressed EMA, CEA, CA19-9, CDX-2, and Ki-67 (labeling stomach and colorectum. The data indicated primary gastric SRCC frequently express EMA but not CDX-2 whereas primary colorectal SRCC frequently express CDX-2 but not EMA. These findings also suggest that EMA and CDX-2 are down-regulated during the gastric SRCC carcinogenesis. This down regulations may be associated with the malignant transformation of gastric SRCC. The data of colorectal SRCC suggest EMA is markedly down-regulated and also suggest that this EMA down-regulation may be associated with the carcinogenesis of colorectal SRCC. The expression pattern of EMA and CDX-2 may be useful in differential diagnosis between primary gastric SRCC and primary colorectal SRCC in the metastatic sites of SRCC.

  11. Extraction and anticoagulant activity of sulfated polysaccharides from Caulerpa cupressoides var. lycopodium (Vahl C. Agardh (Chlorophyceae = Extração e atividade anticoagulante dos polissacarídeos sulfatados da clorofícea Caulerpa cupressoides var. lycopodium (Vahl C. Agardh = Extração e atividade anticoagulante dos polissacarídeos sulfatados da clorofícea Caulerpa cupressoides var. lycopodium (Vahl C. Agardh.

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    José Ariévilo Gurgel Rodrigues

    2011-04-01

    Full Text Available The reportedly low standard quality of heparin (HEP for use in cardiac surgeries has led to concern in the Brazilian and international markets. Sulfated polysaccharides (SPs from seaweeds have been regarded as promising substitutes for HEP. The aim of this study was to sequentially extract total SPs (TSPs from Caulerpa cupressoides (Chlorophyceae with papain in 100 mM sodium acetate buffer (pH 5.0 containing 5 mM cysteine and 5 mM EDTA, followed byfractionation by ion-exchange chromatography (DEAE-cellulose, and then evaluate the anticoagulant potential of SP fractions by activated partial thromboplastin time (APTT using normal human plasma and compare it to standard HEP (193 IU mg-1. The obtained fractions were chemically characterized by chemical composition and agarose gel electrophoresis. The yield was 4.61%, and three fractions of SP (F I, F II and F III eluted with 0.50, 0.75 and 1.00 M of NaCl,respectively, were observed on chromatography profiles; however, differences in charge densities patterns and degree of resolution among them were revealed by electrophoresis. SPs were capable of modifying APTT only in fractions eluted with 0.75 M of NaCl, whose activities were 23.37 and 25.76 IU mg-1, respectively, and the charge density was prerequisite to activity. Therefore, C. cupressoides is a source of SPs possessing low anticoagulant potential compared to HEP.O baixo padrão de qualidade outrora declarado da heparina (HEP para o uso em cirurgias cardíacas tem levado preocupação nos mercados nacional e internacional. Os polissacarídeos sulfatados (PSs de algasmarinhas têm sido considerados como promissores substitutos para HEP. Objetivou-se a extrair sequencialmente PSs totais (PSTs da clorofícea Caulerpa cupressoides com papaína em tampão acetato de sódio 100 mM (pH 5,0 contendo cisteína 5 mM e EDTA 5 mM, fracionar por cromatografia de troca iônica (DEAE-celulose e avaliar o potencial anticoagulante das frações de PS por meio do

  12. The principal nuclear wastes paths at the Cea; Les principales filieres de dechets nucleaires au CEA

    Energy Technology Data Exchange (ETDEWEB)

    Toly, J.A. [CEA Saclay, Dir. du Patrimoine et de l' Assainissement DPA, 91 - Gif sur Yvette (France)

    2001-07-01

    The different channels of radioactive waste are detailed, the objectives, the particularities, the costs for the different paths are reviewed, and the question of the waste acceptance by the public is a part in the choice of solutions. (N.C.)

  13. Combination of diatomaceous earth and powder deltamethrin for insect control in stored corn Combinação de terra de diatomácea e deltametrina em pó para o controle de insetos em milho armazenado

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    Fabiane Cristina Ceruti

    2005-12-01

    Full Text Available The use of diatomaceous earth (DE is a very efficient insect control measure in stored grain IPM due to its low cost, easy application, reduction of active ingredient residues, lower environmental contamination and operator safety. The objective of this research was to evaluate the efficacy of different dosages of DE mixed with powder deltamethrin for controlling Sitophilus zeamais in stored corn. Samples of 100 g of clean and dry corn, in three replicates, were submitted to the following treatments: DE (Keepdry®, at the dosages of 500, 750 and 1000 g/t; powder deltamethrin (K-Obiol® at 0,5 g a.i. /t and 1,0 g a.i. /t; and combinations of the lowest and highest DE dosages with the two dosages of deltamethrin. Thirty adults of S. zeamais were placed in each vial with the treated grains and kept in environment chambers at 25ºC. Mortality was evaluated from the 1st to the 28th day. In the treatments mixing DE with deltamethrin or deltamethrin alone, the mortalyti was registered since the first day. In the treatments using only DE, the first dead insects were recorded after the 3rd day, especially in the highest dosages. After the 7th day, however, there was no statistical difference among all treatments, except for the lowest dosage of DE which reached a satisfactory control level only by the 14th day. It was concluded that treatments using DE combined with low dosages of powder deltamethrin represent an efficient control measure against S. zeamais in stored corn because insect mortality is faster than in treatments using DE alone and residues of active ingredients are much lower than using the insecticide in high dosages.O uso de terra de diatomácea (TD representa uma medida de controle importante em programas de MIP de armazenamento devido ao baixo custo, facilidade de aplicação, redução do nível de resíduos de ingrediente ativo e da contaminação ambiental e maior segurança para o operador. O objetivo desta pesquisa foi avaliar a

  14. Capacidade reprodutiva e preferência da traça-das-crucíferas para diferentes brassicáceas Reproductive capacity and preference of the diamondback moth feeding on different brassicacea

    Directory of Open Access Journals (Sweden)

    Sergio A De Bortoli

    2011-06-01

    Full Text Available O objetivo desta pesquisa foi comparar diferentes cultivares de brassicáceas em relação à capacidade reprodutiva e preferência para alimentação e oviposição da traça-das-crucíferas. Os experimentos foram realizados utilizando-se as cultivares de repolho Midori, Chato-de-Quintal, híbridos da Top Seed® - Agristar (TPC 308, TPC 681 e TPC 668, couve-flor Bola de Neve, couve brócolis Ramoso Piracicaba Precoce e couve Manteiga da Geórgia, sendo esta última utilizada como padrão de suscetibilidade. Por meio dos dados biológicos de P. xylostella foram estimados os parâmetros necessários para a construção de tabela de vida de fertilidade, para comparação das cultivares testadas em relação à capacidade reprodutiva da praga. Em gaiolas de criação da traça-das-crucíferas foram colocados quatro quartos de folha, dois a dois, que justapostos formavam um círculo de 8 cm de diâmetro, confrontando-se os materiais dois a dois. As partes foram dispostas equidistantemente, para realização do teste de dupla chance de escolha (preferência para alimentação e oviposição e de múltipla chance de escolha, confrontando todos os substratos (preferência para alimentação. As cultivares que proporcionaram melhor desenvolvimento e reprodução para a traça-das-crucíferas foram couve Manteiga da Geórgia e couve brócolis. Para preferência alimentar constatou-se alta suscetibilidade em couve Manteiga e TPC 681 e para preferência de oviposição alta preferência para couve-flor Bola de Neve. Com isso, sugere-se a divisão das cultivares estudadas em quatro classes distintas: repolho Midori como moderadamente resistente (MR; couve-flor Bola de Neve e repolho Chato-de-Quintal como suscetíveis (S; couve brócolis, TPC308, TPC681 e TPC668 como moderadamente suscetíveis (MS; e couve Manteiga como altamente suscetível (AS.We compared different cultivars of crucifer in relation to reproductive capacity and preference for feeding and

  15. Adubação nitrogenada e potássica de bromeliáceas cultivadas em fibra de coco e esterco bovino Nitrogen and potassium fertilization of Bromeliaceae grown in coconut fiber and cattle manure

    Directory of Open Access Journals (Sweden)

    Tatiana L do Amaral

    2009-09-01

    Full Text Available Neste trabalho objetivou-se avaliar o efeito de doses de nitrogênio e de potássio no crescimento e teor foliar de nutrientes de quatro bromeliáceas comerciais e propor uma formulação de adubação adequada para cada planta estudada. O experimento foi em esquema fatorial (4 x 4, sendo quatro doses de nitrogênio (0; 375; 562,6 e 750 mg de N L-1 e quatro doses de potássio (0; 468,8; 703,2 e 937,6 mg de K L-1, em delineamento em blocos ao acaso, com quatro repetições para Aechmea blanchetiana e Neoregelia 'Sheba' e três repetições para Orthophytum gurkenii e Vriesea gigantea, duas plantas por parcela. As mudas de Aechmea blanchetiana e Neoregelia 'Sheba' foram cultivadas em substrato composto por 50% de fibra de coco + 50% de esterco bovino; as de Orthophytum gurkenii e Vriesea gigantea, em 100% de fibra de coco. As doses de nitrogênio 0; 375; 562,6 e 750 mg de N L-1 e potássio 0; 468,8; 703,2 e 937,6 mg de K L-1 no substrato correspondem, respectivamente, a 0; 187,5; 281,3 e 375 mg N/planta e 0; 234,4; 351,6 e 468,8 mg K/planta. A adubação fosfatada foi fixa, 50 mg de P L-1 no substrato, correspondendo a 25 mg P/planta, exceto para Neoregelia 'Sheba', que foi inoculada com 25 mL/vaso do inóculo micorrízico misto (Glomus geosporum, Acaulospora laevis, Acaulospora mellea e não recebeu adubação fosfatada. A adubação com 305,1 mg N/planta foi a que proporcionou maior incremento na altura de Aechmea blanchetiana. Em Orthophytum gurkenii; a adubação com 250 mg N/planta proporcionou o maior número de folhas e o maior diâmetro da roseta. As adubações nitrogenada e potássica não beneficiaram o crescimento das plantas de Vriesea gigantea. Em Neoregelia 'Sheba', a dose de 315 mg N/planta causou maior incremento em altura e diâmetro da roseta.Levels of nitrogen and potassium fertilization were evaluated on leaf nutrient contents of four commercial bromeliads, to recommend a suitable fertilization formula for each kind of plant

  16. Resposta de Sitophilus oryzae (L., Cryptolestes ferrugineus (Stephens e Oryzaephilus surinamensis (L. a diferentes concentrações de terra de diatomácea em trigo armazenado a granel Response of Sitophilus oryzae (L., Cryptolestes ferrugineus (Stephens and Oryzaephilus surinamensis (L. to different concentrations of diatomaceous earth in bulk stored wheat

    Directory of Open Access Journals (Sweden)

    Airton Rodrigues Pinto Júnior

    2008-11-01

    Full Text Available Formulações de terra de diatomácea de diferentes origens apresentam variação em toxicidade e em características físicas que afetam sua eficácia. Da mesma forma, diferentes espécies de insetos variam quanto a sua suscetibilidade ao produto. Adultos de Sitophilus oryzae (L., Cryptolestes ferrugineus (Stephens e Oryzaephilus surinamensis (L. foram expostos a concentrações de 250, 500, 750, 1000 e 1250g t-1 de uma formulação de terra de diatomácea de origem brasileira (Keepdry®, em trigo armazenado, por diferentes períodos de exposição. Os grãos tratados com as diferentes concentrações foram colocados em frascos, com quatro repetições de 100g de grãos por tratamento, e infestados com os insetos. Os frascos foram mantidos em câmara climatizada a 25°C e 65% UR, avaliando-se a mortalidade periodicamente. O número de insetos mortos por parcela foi submetido à análise de variância e as diferenças entre as médias discriminadas pelo teste de Tukey a 5%. A mortalidade das três espécies foi diretamente relacionada à concentração e ao tempo de exposição, sendo que os melhores resultados foram obtidos com concentrações acima de 500g t-1. A espécie S. oryzae atingiu 100% de mortalidade somente no 14° dia de exposição, na concentração de 750g t-1. C. ferrugineus foi a espécie mais suscetível ao tratamento com a terra de diatomácea, com 100% de mortalidade a 500g t-1 já no 4° dia. Conclui-se que a terra de diatomácea utilizada apresenta um nível de controle satisfatório, e pode ser utilizada em programas de manejo de insetos, em trigo armazenado.Formulations of diatomaceous earth from different sources show variation in toxicity and in certain physical characteristics which can affect product efficacy. Also, different insect species show variation in their susceptibility to the product. Adults of Sitophilus oryzae (L., Cryptolestes ferrugineus (Stephens and Oryzaephilus surinamensis (L. were exposed to wheat

  17. Estudo de viabilidade técnica, econômica e ambiental preliminar da aplicação da tecnologia de Tratamento Térmico de Resíduos e Materiais Multifásicos-TTRM a resíduos de terra diatomácea de usina genérica de produção de biodiesel.

    OpenAIRE

    Luiz Augusto de Oliveira Costa

    2014-01-01

    O cenário mundial de matriz energética apresenta dados crescentes de contribuição das energias renováveis. No Brasil, o governo tem realizado esforços para aumento da parcela de combustíveis renováveis, e com isso isso também para o aumento da produção de biodiesel. O principal processo de fabricação de biodiesel com seu polimento em via seca gera quantidades significativas de resíduos, dentre eles, o resíduo de terra diatomácea, com potenciais características de inflamabili...

  18. Assembléias de diatomáceas como indicadores de condições de campo e de laboratório em sistemas lóticos: conservação e gestão da qualidade da água na captação de São Carlos-SP, Brasil

    OpenAIRE

    Taurai Bere

    2011-01-01

    Comunidades perifíticas (especialmente diatomáceas) constituem um sistema rico em informações para o monitoramento ambiental, colocando-as entre os indicadores mais importantes das condições ecológicas em sistemas lóticos. Nesta tese, os estudos de campo e experimentos de laboratório foram realizados para esclarecer os confusos efeitos da seleção do substrato, eutrofização, poluição orgânica, força iônica, padrões de uso do solo e poluição por metais pesados nas comunidades bentônicas de diat...

  19. Diatomáceas epilíticas do rio Itajaí-Mirim, Santa Catarina, Brasil - DOI: 10.4025/actascibiolsci.v27i4.1276 Epilithic diatoms from Itajaí-Mirim River, Santa Catarina, Brazil - DOI: 10.4025/actascibiolsci.v27i4.1276

    Directory of Open Access Journals (Sweden)

    Carlos Ossi da Costa

    2005-03-01

    Full Text Available São apresentados os resultados da análise taxonômica das diatomáceas epilíticas no rio Itajaí-Mirim, Estado de Santa Catarina, com base em amostragens realizadas na estação de primavera (setembro de 2003. Foram identificadas 22 espécies pertencentes a 18 gêneros e 13 famílias. Dentre estes, Gomphonema affine, Hipodonta hungarica, Navicula capitatoradiata, Pleurosira laevis var. laevis, Surirella angusta e Tryblionella levidensis são citações novas para o Estado de Santa Catarina. Houve variação na composição específica da comunidade de diatomáceas nos diferentes trechos do rio para este período, observando-se espécies distribuídas em todos os segmentos amostrados, e outras restritas a trechos mais preservados do sistema lóticoThe results of the taxonomic study of epilithic diatoms from Itajaí-Mirim River in Santa Catarina State, Southern Brazil, are presented. Sampling work was conducted during the spring season (September 2003. The study revealed 22 species belonging to 18 genera distributed in 13 families. Among these species, there are: Gomphonema affine; Hipodonta hungarica; Navicula capitatoradiata; Pleurosira laevis var. laevis; Surirella angusta, and Tryblionella levidensis, that are new records to Santa Catarina State. Species composition of such communities varies along the river according to distinct levels of environmental stress. Species with wide distribution were observed, and others were restricted to pristine areas

  20. Efeito do ácido indolbutírico e épocas de estaqueamento sobre o enraizamento de estacas herbáceas de figueira (Ficus carica L. = Effect of indolbutiric acid and times of cutting on rooting of herbaceous cuttings of fig (Ficus carica L.

    Directory of Open Access Journals (Sweden)

    Luciane Arantes de Paula

    2009-01-01

    Full Text Available Este trabalho teve como objetivo verificar o efeito de seis concentrações de ácido indolbutírico (IBA no enraizamento de estacas herbáceas de figueira (Ficus carica L. sob nebulizaçãointermitente, em três épocas diferentes. Os ensaios foram instalados em maio/2004, setembro/2004 e janeiro/2005, e, em cada época, o delineamento experimental utilizado foi o inteiramentecasualizado, com seis concentrações de IBA (0, 500, 1.000, 1.500, 2.000, 2.500 e 3.000 mg L-1. As estacas foram coletadas na Fazenda de Ensino, Pesquisa e Extensão da Unesp, localizada nomunicípio de Selvíria, Estado de Mato Grosso do Sul, sendo padronizadas com 10 cm de comprimento e duas folhas. Após o preparo das estacas, estas foram tratadas com solução de Metiltiofan, posteriormente imersas nas soluções de IBA por 10 min. Em seguida, realizou-se o plantio em jardineiras plásticas de cor preta, contendo vermiculita, que foram transportadas para telado, com 50% de redução de luz, com sistema de irrigação do tipo nebulização intermitente. Asvariáveis analisadas foram: porcentagem de estacas sobreviventes e enraizadas, número de raízes, comprimento máximo do sistema radicular e massa da matéria seca da raiz. Nas condições em que o trabalho foi conduzido, permite-se concluir que: é viável a propagação herbácea de figueira; houve efeito do IBA apenas em maio, em que a melhor dose foi de 1.000 mg L-1; as melhores épocas para estaquia de estacas herbáceas de figueira são em setembro e janeiro, sem utilização de IBA, nas quais foram obtidos melhores resultados quanto à porcentagem de estacas enraizadas.This work had as objective to verify the effect of six concentrationsof indolbutiric acid (IBA in the rooting of herbaceous cuttings of fig (Ficus carica L. under intermittent mist irrigation, at three different times. The assays were installed in May, Septemberand January, where in each time the used experimental design was entirely randomized

  1. Automatic device for {gamma}-spectrometry in EOLE and Minerve facilities; Dispositif automatique de spectrometrie {gamma} des reacteurs EOLE et Minerve

    Energy Technology Data Exchange (ETDEWEB)

    Laval, V.; Philibert, H. [CEA Cadarache, Dept. d' Etudes des Reacteurs (DER/SPEx/LPE), 13 - Saint-Paul-lez-Durance (France)

    2003-07-01

    Experimental programmes ongoing on EOLE and MINERVE critical facilities of the CEA Experimental Physics Service (SPEx) in Cadarache require fission rate measurements by either integral gamma scanning or particular peak check directly on the irradiated fuel pins. These measurements enables to determine radial and axial fission rate distributions as capture rates of specific isotopes in particular core configurations. Up to now, all the fuel handling were performed manually. The development of a new measurement device, called 'automatic bench' was necessary. The project has been launched in 1999 and delivered in 2001. It is in keeping with the frame of experimental uncertainties, dosimetry, safety and security improvements. (authors)

  2. Observations of Radiation Divergence and Stability Driven Slope Flows during the Field Experiment KASCADE

    Science.gov (United States)

    Duine, Gert-Jan; Durand, Pierre; Hedde, Thierry; Roubin, Pierre; Augustin, Patrick; Fourmentin, Marc; Lohou, Fabienne; Lothon, Marie

    2014-05-01

    This work is in the frame of the PhD-thesis entitled "Dispersion of pollutants in stable boundary layer conditions in the middle valley of the Durance", financed by the Commissariat à l'Energie Atomique (CEA) and jointly supervised by CEA and Laboratoire d'Aérologie (LA), Toulouse. It takes place in a wider context of R & D work performed at CEA to characterize the site specific atmospheric conditions, with a view to improve the knowledge of the impact of the potential release of pollutants. During the winter of 2013 the intensive field measurement campaign KASCADE (KAtabatic winds and Stability over CAdarache for Dispersion of Effluents) has been carried out at Cadarache, a research centre of CEA, located in South-Eastern France. The stability of the lower atmospheric boundary layer caused by radiative cooling at night, combined with the local orography, strongly affects the conditions for the dispersion of potential pollutants. Understanding the complex patterns of drainage flow and cold pool build up in the smaller valleys confluent to the Durance river is thus a major issue for refining the models used to assess the sanitary and environmental impact of Cadarache. Stability is easily formed in the region and in combination with the orographic complexity, there is a need to study the Stable Boundary Layer (SBL), which potentially can have a large impact on the dispersion of gaseous emissions released by the various facilities of Cadarache. KASCADE was designed to characterize the local SBL in order to feed future planned numerical simulations with WRF and impact studies involving numerical models coping with dispersion. With a focus on night time, a combination of continuous observations (SODAR and a flux-measurement tower of 30 meter [M30]) and 23 Intensive Observational Periods (IOPs) (Tethered Balloon [TB] profiling and radio-soundings) allows to study the relevant phenomena for SBL-formation. M30 was equipped with sonic anemometers at 3 levels for

  3. Activity of the European high heat flux test facility: FE200

    Energy Technology Data Exchange (ETDEWEB)

    Bobin-Vastra, I. [AREVA Centre Technique de Framatome, FE200, Porte Magenta BP181, 71200 Le Creusot Cedex (France) and EFDA Close Support Unit, Boltzmannstr. 2, D-85748 Garching (Germany)]. E-mail: isabelle.bobinvastra@framatome-anp.com; Escourbiac, F. [Association Euratom-CEA, CEA/DSM/DRFC, CEA/Cadarache, F-13108 Saint Paul lez Durance (France)]. E-mail: escourbi@drfc.cad.cea.fr; Merola, M. [EFDA Close Support Unit, Boltzmannstr. 2, D-85748 Garching (Germany)]. E-mail: mario.merola@tech.efda.org; Lorenzetto, P. [EFDA Close Support Unit, Boltzmannstr. 2, D-85748 Garching (Germany)]. E-mail: lorenzp@tech.efda.org

    2005-11-15

    FE200 is an electron beam (EB) 200 kW test facility resulting since 1991 from partnership between Framatome Technical Centre in Le Creusot (France) and Tore Supra team in CEA Cadarache (France). It is dedicated to high heat flux testing of small and medium-sized plasma facing components. The performed tests are thermal fatigue tests (100,000 since 1992), critical heat fluxes, disruptions, glancing incidence tests on materials such as Cu-Al25 and CuCrZr alloys, carbon fibre composite (CFC) or tungsten (W). The thermal fatigue behaviour of some primary first wall (PFW), hypervapotron and divertor components is described.

  4. Confocal microscopy: A new tool for erosion measurements on large scale plasma facing components in tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Gauthier, E., E-mail: eric.gauthier@cea.fr [CEA/DSM/IRFM, CEA Cadarache, Saint-Paul-lez-Durance (France); Brosset, C.; Roche, H.; Tsitrone, E.; Pégourié, B.; Martinez, A. [CEA/DSM/IRFM, CEA Cadarache, Saint-Paul-lez-Durance (France); Languille, P. [PIIM, CNRS-Université de Provence, Centre de St Jérôme, 13397 Marseille, Cedex 20 (France); Courtois, X.; Lallier, Y. [CEA/DSM/IRFM, CEA Cadarache, Saint-Paul-lez-Durance (France); Salami, M. [AVANTIS CONCEPT, 75 Rue Marcelin Berthelot, 13858 Aix en Provence (France)

    2013-07-15

    A diagnostic based on confocal microscopy was developed at CEA Cadarache in order to measure erosion on large plasma facing components during shutdown in situ in Tore Supra. This paper describes the diagnostic and presents results obtained on Beryllium and Carbon Fibre Composite (CFC) materials. Erosion in the range of 800 μm was found on one sector of the Toroidal Pumped Limiter (TPL) which provides, by integration to the full limiter a net carbon erosion of about 900 g over the period 2002–2007.

  5. Bulk shielding benchmark experiment at Frascati neutron generator (FNG)

    Energy Technology Data Exchange (ETDEWEB)

    Batistoni, P.; Angelone, M.; Martone, M.; Pillon, M.; Rado, V. [Associazione EURATOM-ENEA sulla Fusione, Frascati (Italy); Santamarina, A.; Abidi, I.; Gastaldi, B.; Martini, M.; Marquette, J.P. [CEA Centre d`Etudes de Cadarache, 13 - Saint-Paul-lez-Durance (France)

    1994-11-01

    In the framework of the European Fusion Technology Program, ENEA (Italian Agency for New Technologies, Energy and the Environment) - Frascati and CEA (Commissariat a` l`Energie Atomique) - Cadarache, in collaboration performed a bulk shielding benchmark experiment, using the 14-MeV Frascati neutron generator (FNG), aimed at obtaining accurate experimental data for improving the nuclear data base and methods used in shielding designs. The experiment consisted of the irradiation of a stainless steel block by 14-MeV neutrons. The experimental results have been compared with numerical results calculated using both Sn and Monte Carlo transport codes and the cross section library EFF.1 (european fusion file).

  6. La medición y vigilancias de la enfermedad de la mancha foliar producida por la sigatoka negra (Mycospharella fijiensis var diformis Morelet en la producción de musáceas: un enfoque para lograr la sostenibilidad del desarrollo

    Directory of Open Access Journals (Sweden)

    Edgardo Vargas Jarquín

    2013-05-01

    Full Text Available En el presente trabajo se discute la necesidad de utilizar tecnología, como el procesamiento digital de imágenes para mejorar los procesos de medición y vigilancia de la enfermedad de la mancha de la hoja causada por SIGATOKA NEGRA (Mycospharella fijiensis var diformis Morelet, pero partiendo de un análisis epistemológico que fundamenta al desarrollo sostenible, que es el marco dentro del cual se encuentra sentido a la aplicación de esta tecnología. Así se define que es la gobernabilidad benéfica del ambiente lo que dirige la gestión de los diferentes actores y esta se da en virtud de comprender, mantener, proteger y administrar la complejidad ambiental.  Se señala como uno de los principales inconvenientes de la producción de musáceas la enfermedad de la sigatoka negra, pues produce costos de producción de aproximadamente 1.300 dólares al año costo en uso y aplicación de pesticidas.  Se discute sobre el enfoque de los trabajos de investigación para el desarrollo sostenible en el cultivo de las musáceas.  Se presentan dos experiencias para medir y vigilar la sigatoka negra. En un caso se desarrolla un sistema convencional denominado SiMu, que permite utilizar medios computacionales asistidos para, sobre todo, medir y vigilar la incidencia de la sigatoka. En el otro caso se utiliza tecnología de procesamiento digital de imágenes para realizar ese mismo trabajo pero con un mayor nivel de automatización.  Queda planteada la interrogante de si esta tecnología se puede usar para pequeños y medianos productores, tanto de banano como de plátano, puesto que en ese tipo de unidades no se podría tener una forma económicamente viable para obtener imágenes digitales aéreas.

  7. Enraizamento de estacas herbáceas de quatro clones de umezeiro (Prunus mume Sieb. et Zucc. durante o inverno ameno, em Jaboticabal-SP Rooting of herbaceous cuttings of four mume clones (Prunus mume Sieb. et Zucc. during soft winter, in Jaboticabal, São Paulo state, Brazil

    Directory of Open Access Journals (Sweden)

    Newton Alex Mayer

    2003-12-01

    Full Text Available Estudos realizados no Brasil com o umezeiro (Prunus mume Sieb. et Zucc. relatam promissoras perspectivas de utilização desta espécie como porta-enxerto para pessegueiro e nectarineira, em função de sua rusticidade, adaptação ao inverno brando, compatibilidade com Prunus persica, redução do vigor das plantas e melhoria da qualidade dos frutos. Entretanto, em função da propagação por sementes, tem sido observadas diferenças de vigor entre as plantas, resultando em pomares muito heterogêneos. Assim, o presente estudo teve por objetivo estudar o enraizamento de estacas herbáceas de quatro clones de umezeiro (Clones 02, 05, 10 e 15 durante o inverno ameno, em Jaboticabal-SP. O experimento foi conduzido entre os meses de junho e agosto, sendo avaliado aos 70 dias após a estaquia. Pelos resultados obtidos, foi possível concluir que é viável a propagação dos clones estudados por enraizamento de estacas herbáceas durante o inverno. Foram observadas diferenças entre os clones quanto à porcentagem de enraizamento, porcentagem de estacas com calo, número e comprimento das raízes. No conjunto das variáveis analisadas, os melhores resultados foram obtidos com os Clones 10 e 15.Studies developed in Brazil with the mume (Prunus mume Sieb. et Zucc. have shown promising perspectives of using this species as rootstock for peach and nectarine trees, in function of its rusticity, adaptation to soft winter, compatibility with Prunus persica, plant vigor reduction and improvement of the fruit quality. However, due to seed propagation, vigor differences have been observed among plants, resulting in very heterogeneous orchards. Thus, the present study had the objective of studying the rooting of herbaceous cuttings of four mume clones (Clones 02, 05, 10 and 15 in intermittent mist during the soft winter, in Jaboticabal, São Paulo State, Brazil. The experiment was carried out between June and August, being evaluated 70 days after the cutting

  8. Historia natural cuantitativa de una relación parásito-hospedero: el sistema Tristerix-cactáceas en Chile semiárido Quantitative natural history of a host-parasite relationship: the Tristerix-cactus system in semiarid Chile

    Directory of Open Access Journals (Sweden)

    RODRIGO MEDEL

    2002-03-01

    Full Text Available Presentamos información cuantitativa de la historia natural de la relación parásito-hospedero constituida por el muérdago holoparásito Tristerix aphyllus (Loranthaceae y sus hospederos cactáceas. Más específicamente, indagamos en los determinantes históricos y biogeográficos de la interacción y cuantificamos la autoecología de la biología floral, polinización, dispersión y parasitismo en este sistema. El impacto del parasitismo sobre la evolución de sistemas defensivos en las cactáceas hospederas es considerado tanto a nivel intraespecífico como interespecífico, tomando en cuenta el potencial para selección mediada por parásitos y la estructura geográfica de la interacción. Finalmente, sugerimos futuras avenidas de investigación en este sistema que incluyen los tópicos de: (i evolución de la virulencia, (ii estructuración de la interacción en mosaico geográfico y, (iii pruebas históricas de adaptación. Estos aspectos permitirán adquirir un mayor conocimiento de la sutileza ecológica y de la evolución de esta especial interacción en los sistemas naturales de Chile semiáridoWe present quantitative information on the natural history of a host-parasite interaction that consists on the holoparasitic mistletoe Tristerix aphyllus (Loranthaceae and its cacti host species. More specifically, we inquire into the historical and biogeographical setting of the relationship, and quantify the autoecology of the floral biology, pollination, seed dispersal, and parasitism of the system. The impact of the mistletoe on the evolution of defense systems is evaluated both at intraspecific and interspecific levels through consideration of the potential for parasite-mediated selection and the geographical structure of the host-parasite interaction. Finally, we suggest prospective lines of research which include aspects related to: (i the evolution of virulence, (ii the geographic structure of the interaction, and (iii the historical

  9. Diatomáceas epífitas em Galaxaura rugosa (J. Ellis & Solander J.V. Lamouroux (Rhodophyta no Arquipélago de Fernando de Noronha, PE, Nordeste do Brasil Epiphytic diatoms on Galaxaura rugosa (J. Ellis & Solander J.V. Lamouroux (Rhodophyta in Fernando de Noronha Archipelago, Pernambuco State, Northeast Brazil

    Directory of Open Access Journals (Sweden)

    Manoel Messias da Silva Costa

    2009-09-01

    Full Text Available Exemplares de Galaxaura rugosa (J. Ellis & Solander J.V. Lamouroux foram coletados nos meses de junho/2006 e junho/2007, em três localidades do Arquipélago de Fernando de Noronha (Atalaia, Porto e Cagarras, com o objetivo de identificar a flora das diatomáceas epífitas que habita o talo da alga. Foram identificados 52 táxons distribuídos nas classes: Coscinodiscophyceae (19%, Fragilariophyceae (21% e Bacillariophyceae (60% denotando uma dominância de indivíduos com simetria bilateral, os quais corresponderam a 81% da flora identificada. As seguintes espécies caracterizaram a estrutura florística das diatomáceas, pois foram encontradas em mais de 70% das amostras analisadas: Amphora sp., Biddulphia biddulphiana (J.E. Smith Boyer, Cocconeis scutellum Ehrenberg, Diploneis bombus Ehrenberg, Grammatophora marina (Lyngbye Kützing, Mastogloia binotata (Grunow Cleve, Navicula longa Grunow, Nitzschia sp., Psammodiscus nitidus (Gregory Round in Mann, Rhabdonema adriaticum Kützing, Trachyneis aspera (Ehrenberg Cleve e Tryblionella coarctata (Grunow Mann. A diversidade específica variou entre média à alta, com os menores valores correspondendo aos florescimentos de Amphora sp. (49,3%, Mastogloia binotata (42,1% e Nitzschia sp. (62,5%.Specimens of Galaxaura rugosa (J. Ellis & Solander J.V. Lamouroux were collected in June 2006 and June 2007 at three localities in Fernando de Noronha Archipelago (Atalaia, Porto and Cagarras, aiming to identify the epiphytic diatom flora that inhabits the algae thallus. A total of 52 taxa were identified, distributed in the classes Coscinodiscophyceae (19%, Fragilariophyceae (21% and Bacillariophyceae (60% with 81% dominance of individuals with pinnate symmetry. The following species characterized the floristic diatom structure being considered very frequent: Amphora sp., Biddulphia biddulphiana (J.E. Smith Boyer, Cocconeis scutellum Ehrenberg, Diploneis bombus Ehrenberg, Grammatophora marina (Lyngbye K

  10. Pegamento e crescimento inicial de enxertos do pessegueiro 'Aurora-1' em clones de umezeiro (Prunus mume Sieb. et Zucc. e 'Okinawa' [Prunus persica (L. Batsch] propagados por estacas herbáceas Tissue union and initial growth of 'Aurora-1' peach buds on mume clones (Prunus mume Sieb. et Zucc. and 'Okinawa' [Prunus persica (L. Batsch] propagated by herbaceous cuttings

    Directory of Open Access Journals (Sweden)

    Newton Alex Mayer

    2005-04-01

    Full Text Available O presente estudo teve por objetivo avaliar o pegamento e o crescimento inicial de enxertos do pessegueiro 'Aurora-1' em clones de umezeiro (Prunus mume Sieb. et Zucc. e 'Okinawa' [Prunus persica (L. Batsch] propagados por estacas herbáceas. Realizaram-se dois experimentos, adotando-se a enxertia de borbulhia por escudo (março e borbulhia por escudo modificada (julho. Com os resultados obtidos, pode-se concluir que é viável a realização da enxertia do 'Aurora-1' nos Clones 05; 10 e 15 de umezeiro e no 'Okinawa', tanto em março quanto em julho, com as metodologias utilizadas. O 'Okinawa' induz crescimento mais rápido ao enxerto, de forma que o ponto máximo do comprimento é atingido em tempo menor.This study aimed to evaluate the tissue union and initial growth of 'Aurora-1' peach buds on mume clones (Prunus mume Sieb. et Zucc. and 'Okinawa' [Prunus persica (L. Batsch] propagated by herbaceous cuttings. Two experiments were carried out, being adopted the chip budding (March and chip budding modified (July. The results showed that accomplishment of 'Aurora-1' peach bud on mume Clones 05, 10 and 15 and 'Okinawa' is viable, in both periods, with the methodologies used. The 'Okinawa' induces faster growth to the bud and the maximum length point is reached in a short time.

  11. Aquatic herbaceous plants of the Amazon floodplains: state of the art and research needed Herbáceas aquáticas das áreas alagáveis amazônicas: estado da arte e estudos necessários

    Directory of Open Access Journals (Sweden)

    Maria Teresa Fernandez Piedade

    2010-06-01

    Full Text Available The Amazonian wetlands cover a vast area subject to a monomodal flood pulse with an annual amplitude averaging 10 m, which defines an aquatic phase and a terrestrial phase of great biological importance. According to the geological origin and the catchment areas, the physical and chemical properties of the wetland will vary, being defined two major groups, the várzeas and the igapós. Although aquatic herbaceous plants do occur in the two types, higher species richness and densities are typical of the várzeas where aquatic herbaceous species, particularly C4 plants may exhibit high biomass values and net primary production - NPP about three times these of the floodplain forest. The aquatic herbaceous plants are very important in the carbon and nutrient budgets of the várzea, since through their decomposition they promote the enrichment of the aquatic system and associated floodplains, both during the aquatic and terrestrial phases of the hydrologic cycle. The major threats to herbaceous aquatic plants are related to the modification and contamination of the habitats owing to their use in economic activities as cattle and buffalo ranching and agriculture. Degradation improves the susceptibility of these systems to fire especially during the terrestrial phase, resulting in economic losses and further degradation of floodplains. Recently oil spills linked to the petroliferous activities in the region are of major concern demanding further and urgent evaluation.As áreas alagáveis amazônicas cobrem uma vasta extensão de terrenos submetidos a um pulso de inundação monomodal de amplitude média anual de 10 m, definindo uma fase aquática e uma fase terrestre de grande importância biológica. Conforme a origem geológica e as áreas de captação, a físico-química das áreas alagáveis irá variar, sendo definidos dois grandes grupos, as várzeas e os igapós. Apesar das plantas herbáceas aquáticas ocorrerem nessas duas tipologias, a maior

  12. Enraizamento de estacas herbáceas do abacateiro ‘Fuerte’ com diferentes períodos de imersão em solução de ácido indolbutírico = Rooting of herbaceous cuttings of ‘Fuerte’ avocado in solution of indol-butiric acid with different times of immersion

    Directory of Open Access Journals (Sweden)

    Ubirajara Ribeiro Mindêllo Neto

    2007-07-01

    Full Text Available Este trabalho foi realizado na Embrapa, Canoinhas, Estado de Santa Catarina, com o objetivo de verificar o efeito de diferentes tempos de imersão em solução de ácido indolbutírico (AIB no enraizamento de estacas herbáceas do abacateiro ‘Fuerte’. As estacas foram coletadas em 25/5/04 de plantas com um ano de idade e preparadas com diâmetroentre 4 a 6 mm e 10 cm de comprimento, permanecendo no terço superior duas folhas cortadas ao meio. Os tratamentos foram os seguintes: 5 e 30 segundos; 5 minutos; 1, 4, 8 e 12 horas em solução de 1000 mg L-1 de AIB. O delineamento experimental foi inteiramente casualizado, com sete tratamentos, quatro repetições e doze estacas por parcela. Após aaplicação do AIB, as estacas foram colocadas em bandejas de poliestireno expandido com 72 células, contendo turfa como substrato e levadas para enraizar em casa-de-vegetação com nebulização intermitente. Após 185 dias, foi realizada a avaliação do experimento. Os períodos de imersão rápida, por 5 e 30 segundos na solução de 1000 mg L-1 de AIB apresentaram-se mais favoráveis ao enraizamento das estacas, sendo superiores estatisticamente aos demais tempos de imersão. Os tempos de imersão superiores a uma hora apresentaram efeito fitotóxico. Recomenda-se para a estaquia herbácea de plantas juvenis do abacateiro ‘Fuerte’ a imersão por 30 segundos em solução de 1000 mg L-1 de AIB.This study was carried out at Embrapa, Canoinhas, state of Santa Catarina, Brazil, aiming to verify the effect of different times of immersion in solution of indol-butiric acid (IBA in the rooting of herbaceous cuttings of ‘Fuerte’ avocado. The cuttings were collected on May 25th, 2004, from one-yearold plants and prepared with a 4-6mm diameter and 10cm long, with 2 remaining leaves cut in the middle, in the upper third part. The treatments were the following: 5 and 30seconds; 5 minutes; 1, 4, 8 and 12 hours in solution of 1000 mg L-1 of IBA. The

  13. Polissacarídeos sulfatados isolados das clorofíceas Caulerpa racemosa e Caulerpa cupressoides – extração, fracionamento e atividade anticoagulante =Sulfated polysaccharides isolated from Caulerpa racemosa and Caulerpa cupressoides (Chlorophyceaes – extraction, fractionation and anticoagulant activity

    Directory of Open Access Journals (Sweden)

    José Ariévilo Gurgel Rodrigues

    2010-04-01

    Full Text Available A incidência de doenças cardiovasculares e os efeitos adversos da heparinoterapia têm motivado a busca por novos agentes terapêuticos e os polissacarídeos sulfatados (PS de algas marinhas têm sido reportados como fontes alternativas para tal. Objetivou-se avaliar o potencial anticoagulante dos PS totais (PST isolados e fracionados das clorofíceas Caulerpa racemosa e Caulerpa cupressoides. Inicialmente, os PST foram extraídos com papaína em tampão acetato desódio 0,1 M (pH 5,0 contendo cisteína 5 mM e EDTA 5 mM, seguidos de fracionamento em coluna de troca iônica de DEAE-celulose com gradiente de NaCl. As frações obtidas foram analisadas por eletroforese em gel de agarose a 0,5% e a atividade anticoagulante, mensurada pelo tempo de tromboplastina parcial ativada (TTPA, usando-se plasma humano normal e comparada a uma curva-padrão de heparina (193 UI mg-1. Verificaram-se semelhantes perfiscromatográficos entre os PS de ambas as espécies, porém com padrões de mobilidades distintas quando as frações foram comparadas por eletroforese. Os PS modificaram o TTPA, cujas atividades anticoagulantes foram de apenas 21,23 e 24,36 UI mg-1, quando eluídos com 0,75 M de sal para C. racemosa e C. cupressoides, respectivamente. Portanto, PS anticoagulantes isolados dasclorofíceas C. racemosa e C. cupressoides resultaram em efeitos anticoagulantes inferiores aos da heparina. Estudos comparativos dessas moléculas também são sugeridos como ferramentas auxiliares na identificação de algas do mesmo gênero.The incidence of cardiovascular diseases and adverse effects from heparintherapy have led to a search for new therapeutic agents, and the sulfated polysaccharides (SP of seaweeds have been reported as alternative sources. The aim of this work was to evaluate the anticoagulant potential of total SP (TSP isolated and fractionated from Caulerpa racemosa and Caulerpa cupressoides (Chlorophyceaes. Initially, the TSP were extracted with papain

  14. Efeito do comprimento de estacas herbáceas de dois clones de umezeiro (Prunus mume Sieb & Zucc. no enraizamento adventício Effect of the length of herbaceous cuttings of two clones of japanese apricot (Prunus mume Sieb & Zucc. in adventicious rooting

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    NEWTON ALEX MAYER

    2002-08-01

    Full Text Available O umezeiro (Prunus mumeSieb & Zucc. é uma rosácea de folhas caducas, nativa da China, cujos frutos e flores são muito apreciados pelos povos orientais. No Brasil, alguns estudos foram realizados visando a sua utilização como porta-enxerto para pessegueiro e nectarineira, dadas as suas características de adaptação, rusticidade, redução do porte da planta e compatibilidade com algumas cultivares de Prunus persica. O presente estudo foi conduzido em câmara de nebulização sob ripado, pertencente ao Departamento de Produção Vegetal da FCAV/UNESP, Câmpus de Jaboticabal-SP. Objetivou-se verificar a influência de quatro comprimentos de estacas herbáceas no enraizamento de dois clones de umezeiro. O material vegetal, identificado como Clone 10 e Clone 15, foi oriundo do Programa de Melhoramento Genético do Instituto Agronômico de Campinas-SP. O experimento foi constituido de fatorial 2 x 4, em blocos casualizados, sendo o fator clone em 2 níveis (Clone 10 e Clone 15 e o fator comprimento de estaca em 4 níveis (12; 15; 18 e 25cm. Pelos resultados observados, verificou-se diferença entre os clones somente na porcentagem de estacas brotadas e número de raízes por estaca. O comprimento da estaca influenciou na porcentagem de enraizamento e na mortalidade das estacas, sendo que estacas maiores tenderam a apresentar maiores porcentagens de enraizamento e menores de mortalidade. As estacas com 12cm, embora apresentando menor número de raízes por estaca, são recomendadas por permitirem a obtenção de um maior número de estacas por planta-matriz. Houve efeito significativo da interação entre os fatores para número e comprimento de raízes.The japanese apricot (Prunus mume Sieb & Zucc. is a Rosaceae of falling leaves, native of China, whose fruits and flowers are quite appreciated by the oriental people. In Brazil, some studies were accomplished seeking its use as rootstock for peach and nectarine trees, due its adaptation

  15. Spatial variation in the structure and composition of the herbaceous community in a semiarid region of northeastern Brazil Variação espacial na estrutura da comunidade herbácea em uma região semiárida do Nordeste do Brasil

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    KA. Silva

    2013-02-01

    Full Text Available In the arid and semiarid environments of the world, microhabitats serve as models for the structure of vegetation communities. The goal of this study was to identify differences in the structures of the herbaceous communities growing on a crystalline substrate and those growing on a sedimentary substrate in a semiarid region of northeastern Brazil. One hundred 1 × 1 m plots were established in each area for quantitative sampling, with 69 species recorded in the crystalline area and 76 in the sedimentary area. The average plant density was higher in the sedimentary area, and average diameters and heights were greater in the crystalline area. The families and species with a high Importance Value Index (IVI and a high Mixed Ecological Value Index (MEVI differed between the areas. Of the species with high densities, only four were found in both areas. Shannon-Weiner diversity index values in the crystalline (2.96 nats/ind.-1 and sedimentary (2.89 nats/ind.-1 areas were similar. Evenness values on both substrates were also similar (0.72 and 0.71 in the crystalline and sedimentary areas, respectively. This study shows that variations in plant establishment conditions between crystalline and sedimentary areas in a semiarid region of northeastern Brazil should be considered as structure-modeling factors for the herbaceous community.Nos ambientes áridos e semiáridos do mundo, os micro-habitats modelam a estrutura das comunidades vegetais. O objetivo deste estudo foi identificar diferenças nas estruturas das comunidades herbáceas instaladas sobre o solo do embasamento cristalino e a bacia sedimentar em uma região semiárida do Nordeste do Brasil. Foram estabelecidas 100 parcelas de 1 × 1 m em cada área para amostragem das comunidades. Foram registradas 69 espécies na área cristalina e 76 na área sedimentar. A densidade média das plantas foi maior na área sedimentar e os diâmetros e as alturas médias foram maiores na área cristalina. As fam

  16. Pré-tratamento com água e doses de ácido indolbutírico para estaquia herbácea de pitangueiras Pre-treatments with water and indole butyric acid dosis for herbaceous cuttings of Surinam cherry

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    Daiane Silva Lattuada

    2011-12-01

    Full Text Available No Brasil, a maioria dos pomares de pitangueira (Eugenia uniflora é formada por mudas do tipo pé-franco, o que torna os plantios com baixa uniformidade genética. A propagação vegetativa via estaquia é uma alternativa viável para propagação de diversas espécies frutíferas, podendo ser utilizada também com as espécies nativas, proporcionando a formação de pomares homogêneos, com a produção de mudas com alta sanidade, além de antecipar a produção. Nesse contexto, conduziu-se um estudo visando à multiplicação vegetativa da pitangueira, em que se testou a estaquia herbácea a partir de estacas coletadas de plantas matrizes jovens e adultas, submetidas a três períodos de imersão em água (0, 24 ou 48 horas, além da aplicação de doses de ácido indolbutírico (0, 2000, 4000 e 6000mg L-1. Foram avaliadas a sobrevivência (%, a retenção e a emissão foliar (n° folhas/ estaca, a calogênese (% e enraizamento das estacas (%. Ao final do experimento, avaliou-se massa fresca e seca de parte aérea e raiz, número de folhas e área foliar. O delineamento experimental foi o completamente casualizado, com três repetições de dez plantas por tratamento para os parâmetros não destrutivos e três repetições de cinco plantas por tratamento para os parâmetros destrutivos. A estaquia herbácea foi eficiente para produzir mudas de pitangueira, especialmente quando utilizadas estacas oriundas de plantas jovens sem necessidade de pré-lavagem nem adição de auxinas exógenas.In Brazil, most of the Surinam cherry (Eugenia uniflora orchards is formed by ungrafted plants, which makes the plantations have low genetic uniformity. The vegetative minicutting propagation is a viable alternative for the propagation of several fruit species, and can also be used with native species providing the formation of orchards with homogeneous populations of plants, with production of seedlings with high health and accelerated propagation process

  17. Fuel Performance Characterisation under Various PWR Conditions: Description of the Annealing Test Facilities available at the LECA-STAR laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Pontillon, Y.; Cornu, B.; Clement, S.; Ferroud-Plattet, M.P.; Malgouyres, P.P. [Commissariat a l' Energie Atomique, CEA/DEN/DEC/SA3C - Centre d' Etudes de Cadarache, BP1, 13108 Saint Paul Lez Durance (France)

    2008-07-01

    The aim to improve LWR fuel behaviour has led Cea to improve its post-irradiation examination capacities in term of test facilities and characterization techniques in the shielded hot cells of the LECA-STAR facility, located in Cadarache Cea center. as far as the annealing test facilities are concerned, fuel qualification and improvement of knowledge require a set of furnaces which are already used or will be used. The main characteristics of these furnaces strongly depend on the experimental objectives. The aim of this paper is to review the main aspects of these specific experiments concerning: (i) fission gas release from high burn up fuel, (ii) global fission product release in severe-accident conditions and (iii) fuel microstructural changes, potential cladding failure, radionuclide source terms... under conditions representative of long term dry storage and geological disposal. (authors)

  18. Experimental results and analysis of core physics experiments, FUBILA, for high burn-up BWR full MOX cores

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, T.; Kikuchi, S.; Kawashima, K.; Kamimura, K. [Japan Nuclear Energy Safety Organization, 3-17-1, Toranomon, Minato-ku, Tokyo 105-0001 (Japan)

    2006-07-01

    JNES has been performing MOX core physics experiments, FUBILA, in the EOLE critical facility of the CEA Cadarache center with collaboration of a French Consortium (CEA and COGEMA). The experiments have been designed to obtain the core physics data of operating conditions of full MOX BWR cores consisting of high burn up BWR MOX assemblies. The experiments consisting of seven different core configurations started from January 2005 and will be completed by August 2006. Theoretical analysis of the experimental data has been also carried out using a deterministic code, SRAC, and a continuous energy Monte Carlo calculation code, MVP, with major nuclear data libraries, JENDL-3.3, 3.2, ENDF/B-VI and JEFF-3.1 for the first critical core. (authors)

  19. Alterações na vegetação herbácea de floresta ombrófila densa decorrentes do uso em uma trilha turística na Serra do Mar em São Paulo, Brasil Alterations in the herbaceous vegetation along a tourist trail in the Serra do Mar, São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Luísa Almeida Maciel

    2011-09-01

    Full Text Available O estudo analisou a vegetação herbácea ao longo de uma trilha de uso público intensivo nos parques Natural Municipal Nascentes de Paranapiacaba (PNMNP e Estadual da Serra do Mar (PESM. Foram analisados os valores de cobertura vegetal, riqueza e número de indivíduos do estrato herbáceo. A metodologia permitiu amostrar 76 unidades (adjacentes a trilha, a 2 m e a 10 m da trilha. Os três parâmetros da vegetação analisados apresentaram valores menores à medida que se afasta perpendicularmente à trilha. Na análise dos indivíduos registrou-se maior número de morfoespécies, maiores cobertura e riqueza nas unidades amostrais adjacentes à trilha. Duas espécies foram detectadas como dominantes, especialmente nas unidades amostrais próximas à trilha: Parodiolyra micrantha e Impatiens wallerianna. Esta última espécie encontra-se na lista oficial de espécies invasoras do município de São Paulo.This study analyzed the herbaceous vegetation along a publically used trail that crosses two important parks: Natural Municipal Nascentes de Paranapiacaba (PNMNP and Estadual da Serra do Mar (PESM. The cover percentage, richness and number of individuals of the herbaceous layer were analyzed based on 76 samples (collected next to, 2 m and 10m from the trail, perpendicularly. The values of the three dependent variables analyzed were smaller in the vegetation that was further (2 and 10m from the trail. The analyses of the individuals sampled showed a higher number of morpho-species, and larger cover and richness, closer the trail. Parodiolyra micrantha and Impatiens wallerianna (which is officially listed as invasive in the Sao Paulo municipality were dominant, especially closer to the trail.

  20. Influência da densidade populacional nas relações entre matéria orgânica carbonácea, nitrogênio e fósforo em rios urbanos situados em áreas com baixa cobertura sanitária Influence of the urban density in the relationship among carbonic organic matter, nitrogen and phosphorous in small rivers with low sanitation coverage

    Directory of Open Access Journals (Sweden)

    Harry Alberto Bollmann

    2006-12-01

    Full Text Available O objetivo principal deste trabalho é a análise da variação da relação entre a matéria orgânica carbonácea (representada pelas Demandas Biológica e Bioquímica de Oxigênio, Nitrogênio Total Kjeldhal e Fósforo Total nas águas de pequenos rios urbanos cujas áreas de drenagem apresentem baixa cobertura sanitária. Para isso, foram selecionadas 4 bacias hidrográficas urbanas com ocupação residencial, densidade populacional entre 0 e 100 hab/ha e similaridade de condições naturais e de ocupação humana. Os resultados mostraram alterações importantes nas relações entre os conteúdos de matéria orgânica carbonácea, Nitrogênio e Fósforo indicando que, a partir de uma condição natural não urbanizada, mesmo pequenas densidades populacionais são capazes de alterar significativamente a qualidade das águas.The purpose of this study is to evaluate the relationship among the carbonic organic matter (measured as Chemical and Biological Oxygen Demand, Total Kjeldhal Nitrogen and Total Phosphorous in small urban rivers with low sanitation coverage in its hydrographic basins. Four basins with similar natural condition and residential occupation but variable urban densities between 0 and 100 inhabitants per hectare were selected. The results show important changes in the carbonic organic matter, Nitrogen and Phosphorous relationships indicating that, compared with a natural condition, even low urban densities can significantly change de water quality.

  1. Report of Activity - 1997; Rapport d`Activite - 1997

    Energy Technology Data Exchange (ETDEWEB)

    Hammer, Philippe [Direction chargee de la Gestion des Dechets, CEA, 92 - Fontenay-aux-Roses (France)

    1999-11-01

    The Report of Activity on 1997 published by Waste Management Division (Direction chargee de la Gestion des Dechets) of French Atomic Energy Authority (Commissariat a l`Energie Atomique) presents the current activity in the framework of CEA Recovery Plan for Civil Centers initiated in 1991, aiming at managing all the radioactive problems issued from its Research and Development Activities. This plan covers three principal directions: management of radioactive wastes resulting from CEA research activities, reprocessing or storing the spent or un-used fuel resulting from research or prototype reactors, recovery measures and dismantling of nuclear facilities. In the field of radioactive waste management important projects, assuring the waste processing equipment, were developed in 1997 at Saclay (STELLA Installation), Cadarache (AGATE Installation) and Marcoule (ATENA Installation). The Radioactive Waste Storage TFA was put into operation at Cadarache. In the field of out-of-use fuel, in 1997 the fuel reprocessing units CARAMEL and UNGG were finished while as temporary storage for fuels waiting to be processed the CASCAD facility at Cadarache was assigned. Finally, concerning the recovery/dismantling activities, priority was granted to recover: the Radiochemical Lab. at Fontenay, the pilot workshop and UP1 plant of COGEMA at Marcoule, the EL4 reactor (in a joint action with EDF), and the AT1 pilot workshop at Cherbourg. The report is structured on five chapters with the following content: 1. The radioactive wastes; 2. The out-of-use fuels; 3. The dismantling of the definitively stopped installations; 4. The waste management at DAM (Direction des Applications Militaires); 5. Recovery activities at Marcoule 34 figs., 24 tabs.

  2. Nuclear data production, calculation and measurement: a global overview of the gamma heating issue

    Directory of Open Access Journals (Sweden)

    Gueton O.

    2013-03-01

    Full Text Available The gamma heating evaluation in different materials found in current and future generations of nuclear reactor (EPRTM, GENIV, MTR-JHR, is becoming an important issue especially for the design of many devices (control rod, heavy reflector, in-core & out-core experiments…. This paper deals with the works started since 2009 in the Reactor Studies Department of CEA Cadarache in ordre to answer to several problematic which have been identified as well for nuclear data production and calculation as for experimental measurement methods. The selected subjects are: Development of a Monte Carlo code (FIFRELIN to simulate the prompt fission gamma emission which represents the major part of the gamma heating production inside the core Production and qualification of new evaluations of nuclear data especially for radiative capture and inelastic neutron scattering which are the main sources of gamma heating out-core Development and qualification of a recommended method for the total gamma heating calculation using the Monte Carlo simulation code TRIPOLI-4 Development, test and qualification of new devices dedicated to the in-core gamma heating measurement as well in MTR-JHR as in zero power facilities (EOLE-MINERVE of CEA, Cadarache to increase the experimental measurement accuracy.

  3. Nuclear data production, calculation and measurement: a global overview of the gamma heating issue

    Science.gov (United States)

    Colombier, A.-C.; Amharrak, H.; Fourmentel, D.; Ravaux, S.; Régnier, D.; Gueton, O.; Hudelot, J.-P.; Lemaire, M.

    2013-03-01

    The gamma heating evaluation in different materials found in current and future generations of nuclear reactor (EPRTM, GENIV, MTR-JHR), is becoming an important issue especially for the design of many devices (control rod, heavy reflector, in-core & out-core experiments…). This paper deals with the works started since 2009 in the Reactor Studies Department of CEA Cadarache in ordre to answer to several problematic which have been identified as well for nuclear data production and calculation as for experimental measurement methods. The selected subjects are: bid.1"> Development of a Monte Carlo code (FIFRELIN) to simulate the prompt fission gamma emission which represents the major part of the gamma heating production inside the core bid.2"> Production and qualification of new evaluations of nuclear data especially for radiative capture and inelastic neutron scattering which are the main sources of gamma heating out-core bid.3"> Development and qualification of a recommended method for the total gamma heating calculation using the Monte Carlo simulation code TRIPOLI-4 bid.4"> Development, test and qualification of new devices dedicated to the in-core gamma heating measurement as well in MTR-JHR as in zero power facilities (EOLE-MINERVE) of CEA, Cadarache to increase the experimental measurement accuracy.

  4. The single-particle microbeam facility at CEA-Saclay

    Energy Technology Data Exchange (ETDEWEB)

    Khodja, H. [DSM/IRAMIS/SIS2M, CEA Saclay, F-91191 Gif-sur-Yvette Cedex (France); CNRS, UMR9956, Laboratoire Pierre Suee, F-91191 Gif-sur-Yvette Cedex (France)], E-mail: hicham.khodja@cea.fr; Hanot, M.; Carriere, M.; Hoarau, J. [DSM/IRAMIS/SIS2M, CEA Saclay, F-91191 Gif-sur-Yvette Cedex (France); CNRS, UMR9956, Laboratoire Pierre Suee, F-91191 Gif-sur-Yvette Cedex (France); Angulo, J.F. [DSV, IRCM, SRO, Laboratoire de Genetique de la Radiosensibilite, F-92265 Fontenay aux Roses (France)

    2009-06-15

    Low dose and non-targeted effect studies continue to attract the attention of a growing number of radiobiologists. Experimental setups based on light ion microbeams constitute a tool of choice for this kind of investigations. However, a careful attention must be given to experimental conditions, as setup-induced stress levels should be well below those induced by the irradiation itself. Here, we present the current status of the single-particle microbeam facility that has been developed these last years at the nuclear microprobe of Saclay. The driving idea was to build a facility in which local irradiation studies are performed in an environment close to cellular biology standards. This facility includes unique features, such as (i) a compact setup that allows easy access and vertical irradiation mode, (ii) a collimated beam that can be mechanically positioned under the desired cells at a very fast speed, avoiding the requirement of a focusing element and (iii) a controlled environment (temperature, CO{sub 2}, humidity) that allows performing of very long term experiments on cultured cells. Fluorescent techniques are implemented and permit in situ monitoring of cellular responses to irradiations. Several radiobiological studies are already underway and this will be illustrated with recent results regarding DNA damage and reactive oxygen species signaling time courses following targeted irradiations.

  5. On the possibility of a bridge between CBA and CEA

    DEFF Research Database (Denmark)

    Hansen, Bodil Olai; Hougaard, Jens Leth; Keiding, Hans

    2004-01-01

    cost-benefit analysis, cost-effectiveness analysis, aggregation of preferences, quality-adjusted life years......cost-benefit analysis, cost-effectiveness analysis, aggregation of preferences, quality-adjusted life years...

  6. IDRC/CEA Programming 2006-2011 | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... health and education for the poor; and (c) the development of innovative mechanisms for increased citizenship participation and a good governance. Download the PDF : Programming 2006 2011. We fund researchers driving global change. Careers · Contact Us · Subscribe · Unsubscribe · Site map. Follow us; Facebook ...

  7. Dos nuevas Bignoniáceas del Valle del Magdalena

    Directory of Open Access Journals (Sweden)

    Dugand Armando

    1942-11-01

    Full Text Available Memora Romeroi: La especie aquí descrita pertenece a la sección Eumemora K. Schum. y es muy afín, según descripción, a M. caracasana K. Schum., de Venezuela, pero se distingue principalmente por tener racimos florales mucho más alargados, geminados y axilares, con 8, 12 a más flores opuestas, y por las brácteas infracalicinales de forma anchamente espatulada. Además, el cáliz y la corola son más cortos, particularmente el tubo basilar de esta última. EI raquis foliar y especialmente los peciolulos de M. Romeroi son diminutamente pubérulos, al menos durante mucho tiempo, y esta pubescencia menuda se presenta también en el raquis floral. / Tanaecium exitiosum: El doctor Rafael Mora, colector de esta muy interesante nueva especie, anota lo siguiente: "Arbusto que alcanza una altura de 2 metros; ocasionalmente crece más, arrollándose como bejuco a las otras plantas; las flores son de color blanco y de aspecto tubular alargado. La planta es abundante en las regiones secas de Barranca Bermeja y hay potreros que están completamente invadidos por ella".

  8. 21. ATSR congress - Book of abstracts; 21eme congres de l'ATSR - Recueil des resumes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-10-15

    This document brings together the abstracts of all presentations given at the 21. congress of the French association for radiation protection techniques and sciences (ATSR) on the topic of Radiation protection and communication (sociology and communication impact in radiation protection): 1 - radiation protection: a permanent conciliation (G. Berne, SPR Cadarache); 2 - the nuclear argument group (M. Chevalier, R. Rzekiecki, GASN); 3 - role of the technical accreditation centre for radiation protection instrumentation (CTHIR) in radiation protection (G. Bicheron, P. Franco, IPSN); 4 - genotoxicity evaluation of ionizing radiations in a population of industrial radiologists using the lymphocyte micro-nuclei test (Sari-Minodier, T. Orsiere, D. Charrier, A. Botta, Laboratory of Bio-geno-toxicology, Medicine School, Marseille - AIMT 13, Martigues); 5 - impact of iodine 131 effluents from a cancer center on the radioactivity levels of the waste water industry ( E. Desjardins, S. Laugle, J-C. Houy, Centre Eugene Marquis, Rennes); 6 - exposed areas and personnel reclassification in medical establishments (S. Laugle, J-C. Houy, Centre Eugene Marquis, Rennes); 7 - 2SNM - a tool used by the navy for the real-time monitoring of its nuclear facilities (Y. Baron, Navy Military Staff); 8 - Intervention of the Army health service in case of radio-biological-type accident during peacetime (P.M. Curet, M. Croq, Armies Radiobiological Protection Service); 9 - the first aid chain in case of nuclear accident (L. Jorda, fire and safety Services of Bouches-du-Rhone; P. Rigaud, Central group, technological risks unit); 10 - Initiation to radioactivity in seventh grade classes of schools (G. Goulin (physics teacher, college Mignet Aix-en-Provence; J-C. Blanc, G. Juste, ATSR); 11 - communication for young people (H. Bernard, M. Gerster-Martinez, CEA-Cadarache); 12 - major risks, preventive information at Aix-en-Provence (P. Lespinat (Aix-en-Provence city security unit); 13 - scientific

  9. Development of the fuel HTR/VHTR at the CEA; Developpement du combustible HTR/VHTR au CEA

    Energy Technology Data Exchange (ETDEWEB)

    Phelip, M.; Charollais, F.; Lambert, Th

    2005-07-01

    This presentation brings together the slides presented during the conference of the SESC/SPUA the 28 January 2005. The first part is devoted to the fuel behavior under irradiation, the second one to the main objectives of the program and the last part to the international collaboration. It provides information on the fuel behavior under irradiation, the fuel fabrication and performance, the SIROCCO program, the european contacts and the simulation programs. (A.L.B.)

  10. Copper Cu 64 Anti-CEA Monoclonal Antibody M5A PET in Diagnosing Patients With CEA Positive Cancer

    Science.gov (United States)

    2017-10-27

    Breast Cancer; Colon Cancer; Extrahepatic Bile Duct Cancer; Gallbladder Cancer; Gastrointestinal Cancer; Liver and Intrahepatic Biliary Tract Cancer; Lung Cancer; Metastatic Cancer; Pancreatic Cancer; Rectal Cancer; Thyroid Gland Medullary Carcinoma; Unspecified Adult Solid Tumor, Protocol Specific

  11. French nuclear tests: the medical follow up of Cea participating personnel; Essais nucleaires francais: le suivi medical des participants CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    For the personnel exposed to the risk of ionizing radiations, two types of examinations, in the aim of detecting any track of internal contamination were practiced at regular interval, at the arrival and at the departure from the site. A gamma spectrometry, and radio toxicological examination of feces and urines were practiced. furthermore, the exposed personnel received a specific film devoted to measure their external dosimetry. The same examinations were made for the local personnel and for the personnel of intervening societies. (N.C.)

  12. Moscas frugívoras associadas a mirtáceas e laranjeira "Céu" na região do Vale do Rio Caí, Rio Grande do Sul, Brasil Frugivorous flies in myrtaceans and orange trees 'Céu' in the region of Vale do Rio Caí, Rio Grande do Sul State, Brazil

    Directory of Open Access Journals (Sweden)

    Tacimara Gattelli

    2008-02-01

    Full Text Available Este estudo teve o objetivo de reconhecer as espécies de moscas frugívoras em mirtáceas: Eugenia uniflora L., Campomanesia xanthocarpa Berg., Psidium cattleianum Sabine, Psidium guajava L. e Acca sellowiana (Berg. Burret., bem como em Citrus sinensis (L. Osbeck (Rutaceae, na região do Vale do Caí, RS. Os frutos foram coletados no período de maturação de cada espécie frutífera, entre outubro de 2004 e julho de 2005, levados ao laboratório e acondicionados em potes com areia mantidos a 25 ± 1°C; 80 ± 10% UR e fotofase de 12 horas. Os pupários obtidos foram individualizados e suas características foram registradas. De Tephritidae foi registrada apenas Anastrepha fraterculus (Wiedemann e de Lonchaeidae Neosilba n. sp. 3, Neosilba zadolicha McAlpine & Steyskal e Neosilba certa (Walker. As duas últimas são novos registros para o Rio Grande do Sul. Apenas em P. cattleianum foram registradas todas as espécies de moscas encontradas neste trabalho. Os resultados evidenciam que A. fraterculus é a espécie de mosca-das-frutas de maior ocorrência para a região do Vale do Caí, RS, nas frutíferas estudadas.This study aimed at recognizing frugivorous flies species in Myrtaceae: Eugenia uniflora L., Campomanesia xanthocarpa Berg. Psidium cattleianum Sabine, Psidium guajava L. and Acca sellowiana (Berg. Burret., as well as in Citrus sinensis (L. Osbeck (Rutaceae, at Vale do Cai region, Rio Grande do Sul. Fruits were collected at the maturation stage of each fruit species between October 2004 and July 2005, and at the laboratory they were placed in pots with sand and were kept at 12h photoperiod, 80 ± 10% RH and 25 ± 1°C. Pupae were individualized and their characteristics were recorded. In Tephritidae only Anastrepha fraterculus (Wied. was recorded and in Lonchaeidae, Neosilba n. sp. 3, Neosilba zadolicha McAlpine & Steyskal and Neosilba certa (Walker. These last two species were recorded for the first time in Rio Grande do Sul. Only on

  13. Análisis de la variabilidad genética de la colección colombiana de musáceas usando marcadores isoenzimáticos Analysis of the genetic variability of colombian collection of Musaceae using isozyme markers

    Directory of Open Access Journals (Sweden)

    Martha C Giraldo

    2011-04-01

    Full Text Available La Colección Colombiana de Musáceas (CCM es la única a nivel mundial que representa un alto valor por ser la que posee introducciones andinas de altura (> 1500 m.s.n.m.. La caracterización de este germoplasma puede generar valor agregado para su utilización en procesos de selección clonal y para el mejoramiento genético de la especie, mediante el uso de materiales diploides con características transmisibles de importancia. Por esta razón, 33 clones de la CCM conservadas in vitro, fueron evaluadas bioquímicamente mediante 10 enzimas, de las cuales cuatro fueron polimórficas: glutamato oxaloacetil transaminasa (GOT, ab-esterasa (ab-EST, peroxidasa (PRX y diaforasa (DIAP. La enzima GOT fue la más discriminante entre grupos genómicos particulares. PRX, DIAP y ab-EST permitieron evaluar la variabilidad al interior de cada grupo. El estudio facilita el entendimiento de la estructura genética de los genotipos de plátano y banano cultivados en Colombia.The Colombian Collection of Musaceae (CCM represents a great value to the world agriculture for being the only one with high Andean germplasm. The characterization of this germplasm can generate added value to use in processes of clone selection and breeding of the species by using diploid materials with desirable traits to be transferred and thus help alleviate food problems in poor countries. For this reason the CCM 33 clones conserved in vitro, were assessed biochemically using 10 enzymes of which four were polimorfics: oxaloacetil transaminasa glutamate (GOT, ab-esterase (ab-EST, peroxidase (PRX and diaphorase (DIAP. The GOT enzyme was the most discriminating among individual genomic groups. PRX, ab-EST and DIAP allowed us to evaluate the variability within each group. The study provided a better understanding of the genetic structure of the genotypes of plantain and banana grown in Colombia.

  14. Diversidade de bromeliáceas epífitas na Área de Proteção Ambiental Ilha do Combu, Belém, Pará, Brasil Diversity of epiphytic bromeliads in the environmental protection area of Combu Island, Belém, Pará, Brazil

    Directory of Open Access Journals (Sweden)

    Adriano Costa Quaresma

    2012-06-01

    Full Text Available Informações sobre a diversidade no nível de espécie oferecem subsídios importantes para o desenvolvimento sustentável e a conservação biológica. Neste contexto, estudos com Bromeliaceae merecem destaque, especialmente porque o grupo é importante ecologicamente, mas ainda pouco conhecido na Região Norte. Neste trabalho, foram demarcadas duas parcelas de 100 m x 100 m em uma floresta de várzea localizada na Área de Proteção Ambiental Ilha do Combu, em Belém, Estado do Pará. Cada parcela foi subdividida em oito parcelas de 50 m x 50 m, tendo todas as espécies e espécimes de bromeliáceas epífitas registradas e quantificadas. A diversidade do grupo foi calculada utilizando o índice de Shannon-Wiener. Foram registrados 1.339 indivíduos pertencentes a oito espécies e quatro gêneros. Tillandsia e Aechmea apresentaram maior riqueza. A diversidade de espécies na área foi de H= 1,10, apresentando dominância acentuada de muitos indivíduos em poucas espécies.Information about diversity at the species level offers data for sustainable development and biological conservation. In this context, studies about Bromeliaceae are noteworthy, especially because this group is ecologically important and poorly known in the North Region of Brazil. In this study, two grids (100 m x 100 m were delineated in a floodplain forest in the environmental protection area of Combu Island, Belém, Pará, Brazil. The grids were subdivided into eight grids of 50 m x 50 m, and all species and individuals of epiphytic Bromeliaceae were recorded and quantified. The diversity was calculated using the Shannon-Wiener index. A total of 1,339 individuals, belonging to eight species and four genera were recorded. Tillandsia and Aechmea presented the greatest richness. The diversity of species was H= 1.10, presenting sharp dominance of many individuals of few species.

  15. Enraizamento de estacas herbáceas de mirtilo: influência da lesão na base e do ácido indolbutírico Rooting of herbaceous blueberry cuttings: influence of the base incision and indolbutiric acid

    Directory of Open Access Journals (Sweden)

    Renato Trevisan

    2008-04-01

    Full Text Available O mirtilo (Vaccinium sp. é uma espécie de clima temperado que, por ocasião do período vegetativo, produz abundante quantidade de material vegetal que pode ser utilizado na propagação. Objetivou-se verificar o potencial de enraizamento de estacas herbáceas de diferentes cultivares de mirtilo, tratadas ou não com ácido indolbutírico e com e sem lesão na base. O trabalho foi realizado em dois experimentos, testando a capacidade de enraizamento das cultivares Florida, Woodard, Bluegem, Bluebele, Clímax e Briteblue. No primeiro experimento, as estacas das cultivares foram tratadas com AIB (0, 2500, 5000 e 7500mgL-1. No segundo experimento utilizou-se 2000mgL-1 de AIB, em estacas com e sem lesão na base. O delineamento utilizado foi completamente casualizado com repetições e unidades experimentais adequadas para cada experimento. O uso do ácido indolbutírico e a lesão nas estacas, não proporcionaram estímulo na emissão de raízes adventícias; as cultivares apresentam potencial genético de enraizamento diferenciado, sendo que, a Bluebelle apresentou maiores porcentuais de estacas enraizadas, e a Clímax, os menores porcentuais.Blueberries (Vaccinium sp. are species of temperate climate that, for occasion of the vegetative period, produce large amount of vegetal material that can be used in the propagation. This way, with the aim of verifying the rooting potential of different herbaceous cuttings of blueberry cultivars, with the use or not of indolbutíric acid and base injury. The work was carried out in two experiments, having tested the capacity of rooting of the following cultivars Florida, Woodard, Bluegem, Bluebele, Clímax and Briteblue. In the first experiment, cuttings of cultivars were treated with IBA (0, 2500, 5000 and 7500mg.L-1. On the second experiment one used 2000mg.L-1 of AIB, in cuttings with and without injury in the base. The experimental design was the completely randomized with adjusted repetitions and

  16. Cost-effectiveness analysis of cognitive behaviour therapy for treatment of minor or mild-major depression in elderly patients with type 2 diabetes: study protocol for the economic evaluation alongside the MIND-DIA randomized controlled trial (MIND-DIA CEA).

    Science.gov (United States)

    Chernyak, Nadja; Petrak, Frank; Plack, Kristin; Hautzinger, Martin; Müller, Matthias J; Giani, Guido; Icks, Andrea

    2009-07-01

    Depression and elevated depression symptoms are more prevalent in patients with type 2 diabetes than in those without diabetes and are associated with adverse health outcomes and increased total healthcare utilization. This suggests that more effective depression treatment might not only improve health outcome, but also reduce costs. However, there is a lack of evidence on (cost-) effectiveness of treatment options for minor and mild-major depression in patients with type 2 diabetes. In this paper we describe the design and methods of the economic evaluation, which will be conducted alongside the MIND-DIA trial (Cognitive behaviour therapy in elderly type 2 diabetes patients with minor or mild-major depression). The objective of the economic evaluation (MIND-DIA CEA) is to examine incremental cost-effectiveness of a diabetes specific cognitive behaviour group therapy (CBT) as compared to intensified treatment as usual (TAU) and to a guided self-help group intervention (SH). Patients will be followed for 15 months. During this period data on health sector costs, patient costs and societal productivity/time costs will be collected in addition to clinical data. Person-years free of moderate/severe major depression, quality adjusted life years (QALYs), and cumulative costs will be estimated for each arm of the trial (CBT, TAU and SH). To determine cost-effectiveness of the CBT, differences in costs and effects between the CBT group and TAU/SH group will be calculated. CBT is a potentially effective treatment option to improve quality of life and to avoid the onset of a moderate/severe major depression in elderly patients with type 2 diabetes and minor or mild-major depression. This hypothesis will be evaluated in the MIND-DIA trial. Based on these results the associated economic evaluation will provide additional evidence on the cost-effectiveness of CBT in this target population. Methodological strengths and weaknesses of the planned economic evaluation are discussed

  17. Cost-effectiveness analysis of cognitive behaviour therapy for treatment of minor or mild-major depression in elderly patients with type 2 diabetes: study protocol for the economic evaluation alongside the MIND-DIA randomized controlled trial (MIND-DIA CEA

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    Müller Matthias J

    2009-07-01

    Full Text Available Abstract Background Depression and elevated depression symptoms are more prevalent in patients with type 2 diabetes than in those without diabetes and are associated with adverse health outcomes and increased total healthcare utilization. This suggests that more effective depression treatment might not only improve health outcome, but also reduce costs. However, there is a lack of evidence on (cost- effectiveness of treatment options for minor and mild-major depression in patients with type 2 diabetes. In this paper we describe the design and methods of the economic evaluation, which will be conducted alongside the MIND-DIA trial (Cognitive behaviour therapy in elderly type 2 diabetes patients with minor or mild-major depression. The objective of the economic evaluation (MIND-DIA CEA is to examine incremental cost-effectiveness of a diabetes specific cognitive behaviour group therapy (CBT as compared to intensified treatment as usual (TAU and to a guided self-help group intervention (SH. Methods/Design Patients will be followed for 15 months. During this period data on health sector costs, patient costs and societal productivity/time costs will be collected in addition to clinical data. Person-years free of moderate/severe major depression, quality adjusted life years (QALYs, and cumulative costs will be estimated for each arm of the trial (CBT, TAU and SH. To determine cost-effectiveness of the CBT, differences in costs and effects between the CBT group and TAU/SH group will be calculated. Discussion CBT is a potentially effective treatment option to improve quality of life and to avoid the onset of a moderate/severe major depression in elderly patients with type 2 diabetes and minor or mild-major depression. This hypothesis will be evaluated in the MIND-DIA trial. Based on these results the associated economic evaluation will provide additional evidence on the cost-effectiveness of CBT in this target population. Methodological strengths and

  18. Avaliação da remoção de matéria orgânica carbonácea e nitrogenada de águas residuárias em biorreator de membranas Evaluation of carbonaceous organic matter and nitrogen removal of wastewater in membrane bioreactor

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    Luiz Fernando Bezerra

    2011-09-01

    Full Text Available O presente trabalho objetivou a avaliação da remoção de matéria orgânica carbonácea e nitrogenada, bem como a determinação do fluxo crítico, em biorreator de membranas, com zona pré-anóxica, tratando águas residuárias industriais da produção de aminoácidos. O reator foi operado sob carga orgânica volumétrica de 1,91 kg.DQO.m-3.d-1 e 0,18 kg.NTK.m-3.d-1; a recirculação do reator aeróbio para o reator anóxico foi de quatro vezes a vazão afluente. O reator apresentou médias de remoção de DQO, NTK e NT de 97, 98 e 92%, respectivamente. O sistema de ultrafiltração foi testado em vários fluxos entre 25 e 37 L.m-2.h-1 e determinou-se o fluxo crítico de 28 L.m-2.h-1 quando operado com 11,4 g.L-1 de SST e 35 dias de tempo de retenção celular. Os resultados mostraram que houve viabilidade técnica no uso de biorreator de membranas para remoção de matéria orgânica de águas residuárias industriais da produção de aminoácidos.This study aimed to evaluate the carbonaceous organic matter and nitrogen removal as well as the determination of critical flux in membrane bioreactor, with pre-anoxic zone, treating industrial wastewater of amino acids production. The reactor was operated under organic loading rate of 1.91 kgDQO.m-3.day-1 and 0.18 kgNTK.m-3.day-1, the recirculation from aerobic reactor to anoxic reactor was four times the influent flow rate. The system showed an average removal of COD, TKN and TN of 97, 98 and 92%, respectively. The ultrafiltration system was tested at various fluxes between 25 and 37 L.m-2.h-1, to determine the critical flux of 28 L.m-2.h-1 operating at 11.4 g.L-1 of TSS and 35 days of sludge retention time. The results showed the technical feasibility of using membrane bioreactor to remove organic matter from industrial wastewater of amino acids production.

  19. Heparinoides naturais isolados de rodofíceas (Halymenia sp. arribadas na costa cearense - doi: 10.4025/actascibiolsci.v32i3.6282 Natural heparinoids isolated from Halymenia sp. (Rhodophyceaes delivery on the Ceará coast - doi: 10.4025/actascibiolsci.v32i3.6282

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    Wladimir Ronald Lobo Farias

    2010-09-01

    Full Text Available A crescente carência de heparina (HEP motiva a busca por fontes alternativas de novos anticoagulantes naturais. Objetivou-se avaliar a atividade anticoagulante dos polissacarídeos sulfatados (PS isolados de uma rodofícea do gênero Halymenia, nativa do litoral cearense, Brasil. Os PS totais foram obtidos por digestões consecutivas com papaína em tampão acetato de sódio 0,1 M (pH 5,0, contendo cisteína 5 mM e EDTA 5 mM, seguidas por cromatografia de troca iônica em coluna de DEAE-celulose. As frações obtidas foram concentradas por liofilização e submetidas à eletroforese em gel de agarose a 0,5%. Os ensaios anticoagulantes foram realizados pelo tempo de tromboplastina parcial ativada (TTPA, usando-se plasma de coelho e uma curva padrão de HEP (100 UI MG-1. As extrações (53,96% mostraram diferenças marcantes durante o fracionamento e no grau de resolução dos PS. A espécie apresentou PS com atividade anticoagulante superior a HEP. O TTPA das frações modificou-se acentuadamente entre as extrações, expressando-se de maneira dose-dependente e sofrendo um acréscimo de 110,40 (1ª extração para 143,10 UI MG-1 (3ª extração. Os resultados sugerem que a atividade anticoagulante dos PS isolados de Halymenia sp. foi promovida pela inibição da via intrínseca e/ou comum da cascata de coagulação. As modificações no TTPA possivelmente serão elucidadas pelos mecanismos de ação envolvidos na coagulação e caracterização estrutural desses compostos. Portanto, a rodofícea Halymenia sp. é uma boa fonte de heparinoides e sugerem-se estudos relacionados ao cultivo da espécie, em proteção aos bancos de algas.The increasing demand for heparin (HEP has led to a search for alternative sources of natural anticoagulants. This study aimed to evaluate the anticoagulant activity of sulfated polysaccharides (SP isolated from a Halymenia rhodophyceae genus native to the coast of Ceará, Brazil. Total SP were obtained by consecutive

  20. Rooting of herbaceous cuttings of guava selection 8501-1 submitted to basal lesion and IBA concentrations / Enraizamento de estacas herbáceas da seleção 8501-1 de goiabeira submetidas a lesão na base e a concentrações de AIB

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    Sergio Ruffo Roberto

    2008-08-01

    Full Text Available This work aimed to evaluate the influence of different concentrations of indolebutiric acid (IBA on the rooting potential of 0- cm long herbaceous cuttings of guava selection 850 - , submitted or not to basal lesions. The cuttings were prepared in two ways (with or without basal lesions and submitted to four concentrations of IBA (0 mg L- , ,000 mg L- , ,000 mg L- and 3,000 mg L- . After the lesions were made, the cuttings were placed to root in plastic boxes containing carbonized rice husk. The experiment was randomized with five replicates in 2 x 4 factorial arrangement, where each plot was composed by 0 cuttings. After 85 days, the following variables were evaluated: foliar retention (%; rooted cuttings (%; cutting survival rate (%; cuttings with callus but without roots (%; root number per cutting; root length per cutting and wet and dry root matter per cutting (g. There is no significant contrast amongst the IBA different concentrations related to the percentage of rooted cuttings, but there is a significant difference related to the root number per cutting and wet and dry root matter per cutting where the doses of ,000 and 3,000 mg L- showed the highest averages; the basal lesions do not bring improvements on the cutting rooting potential; the 3,000 mg L- IBA concentrations resulted in the largest number of roots per cutting.Este trabalho objetivou avaliar o efeito de diferentes concentrações de ácido indolbutírico (AIB, na capacidade de enraizamento de estacas herbáceas de goiabeira, preparadas com e sem lesão na base. Foram utilizadas estacas com aproximadamente 0- cm de comprimento, submetidas a dois tipos de preparo (com lesão e sem lesão na base e quatro concentrações do AIB (0 mg L L- , .000 mg L L- , .000 mg L L- e 3.000 mg L L- . As estacas foram colocadas para enraizar em caixas plásticas contendo casca de arroz carbonizada. O delineamento experimental foi o inteiramente casualizado com cinco repetições, em arranjo

  1. Factores abióticos que influencian la germinación de seis especies herbáceas de la zona árida de Chile Abiotic factors effects influencing the germination of six herbaceous species of Chilean arid zone

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    Paola A Jara

    2006-09-01

    Full Text Available La zona árida del norte de Chile presenta un clima seco que impide la emergencia masiva de especies vegetales, excepto cuando se producen escasas e irregulares precipitaciones que modifican las características de aridez y estimulan la germinación de semillas. Los principales factores externos que modifican estructuras y condiciones internas de las semillas son el tiempo de hidratación, iluminación, temperatura y escarificación. En este trabajo se abordaron dos interrogantes: (a ¿la germinación de semillas de seis especies de zonas áridas es regulada por diferentes factores externos o presentan respuestas comunes a una combinación de estímulos? y (b ¿existe correspondencia entre las condiciones germinativas establecidas en laboratorio y las determinadas in situ? Para resolver estas interrogantes se sometieron seis especies herbáceas endémicas y nativas del norte de Chile (Cistanthe salsoloides, Leucocoryne purpurea, Pasithea coerulea, Placea amoena, Schizanthus litoralis y Trichopetalum plumosum a dos experimentos germinativos con combinaciones factoriales de tiempo de hidratación, temperatura e iluminación. Solo S. litoralis fue sometido a un experimento adicional de escarificación y deshidratación. Los resultados determinaron que todas las especies en estudio presentaron respuestas germinativas comunes frente a determinados factores externos, con una máxima germinación al sobrepasar un umbral de 96 h de hidratación y permanecer a niveles de temperatura de 10 a 25 ºC. La respuesta frente a iluminación fue especie dependiente. Schizanthus litoralis solo responde a estímulos externos previo a ser escarificada su semilla. Además, se determinó que existe concordancia entre los factores germinativos determinados en laboratorio y las condiciones naturales de germinación. Por lo tanto, las semillas de las especies en estudio presentan umbrales germinativos semejantes, y las técnicas de germinación en laboratorio deben ser

  2. Species richness and geographic distribution of testate amoebae (Rhizopoda in Brazilian freshwater environments = Riqueza de espécies e distribuição geográfica de amebas testáceas (Rhizopoda em ambientes aquáticos continentais brasileiros

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    Fábio Amodêo Lansac-Tôha

    2007-04-01

    Full Text Available The present study aimed to analyze the species richness of testate amoebae, as well as to describe their geographic distribution and different habitat types in Brazilian freshwater environments. Until now, 346 infrageneric taxa have been recorded, belonging to 13 families and 40 genera. In the Center-West region, 267 taxa were recorded; 188 taxa in the Southeast; 129 taxa in the South, 53 taxa in the North; and 18 taxa in Northeast region. A total of 282 taxa were recorded in plankton; 80 taxa in aquatic macrophytes; 81 taxa insediment; and 73 taxa in moss/sphagnum. The results regarding testate amoebae species richness are not yet conclusive, given that most research on these organisms was carried out in central, southeastern and southern Brazil. The higher number of taxa observed in plankton may be due to the fact that most studies on testate amoebae in Brazil had been carried out in the planktonic compartment, including reservoirs, floodplain lagoons, channels, tributaries and rivers. In addition, the majority of studies with sediment samples were conducted in estuaries or coastal lagoons, where salinity is a restricting factor for the occurrence of these organisms.Este trabalho visa realizar um levantamento da riqueza de espécies de amebas testáceas, bem como descrever a distribuição geográfica e a distribuição em diferentes tipos de habitats desses organismos em ambientes aquáticos continentais brasileiros. Até o momento, são registrados 346 táxons infragenéricos, pertencentes a 13 famílias e 40 gêneros. São registrados 267 táxons na região centro-oeste, 188táxons na região sudeste, 129 táxons na região sul, 53 táxons na região norte e 18 táxons na região nordeste. São registrados 282 táxons no plâncton; 131 táxons em macrófitas aquáticas, 81 táxonsno sedimento e 73 táxons em musgos/esfágnos. Os resultados sobre a riqueza de tecamebas não é ainda conclusiva, visto que a maioria das pesquisas foi conduzida

  3. Analysis of two drying methods on the yield and activity of sulfated polysaccharides extracted from Halymenia sp. (Rhodophyceae=Análise de dois métodos de secagem sobre o rendimento e atividade de polissacarídeos sulfatados extraídos da rodofícea Halymenia sp.

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    Norma Maria Barros Benevides

    2012-01-01

    Full Text Available Sulfated polysaccharides (SPs have attracted growing interest for various biotechnological applications. We evaluated the efficiency of two methods of drying SPs (M I and II extracted from Halymenia sp Rhodophyceae in order to compare the yield, purification and anticoagulant activity. The total SPs (TSPs were first extracted with papain in 100 mM sodium acetate (pH 5.0 containing cysteine and EDTA (5 mM. The TSPs obtained were dried in an oven (M I or lyophilized (M II and then examined by ion exchange chromatography (DEAE-cellulose using the NaCl gradient technique. The fractions were analyzed by 0.5% agarose gel electrophoresis and the in vitro anticoagulant activity was evaluated by the activated partial thromboplastin time test using normal human plasma and compared to heparin (HEP (193.00 IU mg-1. There was a difference in TSP yield of 19.05% and similar chromatographic SP profiles. Electrophoresis revealed fractions with distinct resolutions. The fractions eluted with 0.75 M of salt (M I and II were the most active, measuring 27.40 and 72.66 IU mg-1, respectively, when compared to HEP. Therefore, obtaining SP with anticoagulant activity from Halymenia sp. is more efficient by freeze-drying.Os polissacarídeos sulfatados (PS têm despertado interesse crescente para diversas aplicações em biotecnologia. Avaliou-se a eficiência de duas metodologias de secagem de PSs (M I e II extraídos da rodofícea Halymenia sp. a fim de se comparar o rendimento, a purificação e a atividade anticoagulante. Inicialmente, os PS totais (PSTs foram extraídos com papaína em tampão acetato de sódio 100 mM (pH 5,0 contendo cisteína e EDTA (5 mM. Os PSTs foram secados em estufa (M I ou liofilizados (M II, seguido por cromatografia de troca iônica (DEAE-celulose utilizando um gradiente de NaCl. As frações foram analisadas por eletroforese em gel de agarose a 0,5% e a atividade anticoagulante “in vitro” avaliada por meio do teste do tempo de

  4. Persistence of insecticidal activity and repellency of the diatomaceous earth against the lesser mealworm Alphitobius diaperinus (Panzer, 1797 (Coleoptera: Tenebrionidae / Persistência da ação inseticida e repelência da Terra de Diatomácea para o cascudinho-dos-aviários Alphitobius diaperinus (Panzer, 1797 (Coleoptera: Tenebrionidae

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    Dhyego Thomazoni

    2009-07-01

    Full Text Available The persistence and repellency of the diatomaceous earth (DE formulation was evaluated against the lesser mealworm, Alphitobius diaperinus. Persistence bioassays werw conduced in 20 cm diameter plastic cups with DE-treated poultry litter (172g/m2. The adults were transferred (13g – about 1100 insects and the mortality was assessed by counting and removing dead adult beetles in the cups 10, 20 and 30 days after placement. All procedures were repeated 80, 160, 240, 320 and 400 days after first evaluation. The repellency test was conducted in plastic box (36×24×6 cm L×W×H containing poultry litter trated and non-treated with DE (200g/m2, distribuited in two parts. The adults were added to the litter (13g, and the evaluation ocurred after 1, 4 and 7 days after placement, by counting the insects in the treated and non-treated area. It was verified the inseticidal activity until eight month after litter treatment (60% of mortality, showing the persistence of the product. The repellency activity of the DE was confirmed and it must be considered in a development of control strategies of the lesser mealworm with.A persistência da ação inseticida da terra de diatomácea (TD, e o seu efeito repelente foram avaliados contra o cascudinho-dos-aviários, Alphitobius diaperinus. Para o experimento de persistência foram utilizados potes plásticos (20 cm de diâmetro com cama tratada com TD (172g/m2. Foram liberados 13g de adultos de cascudinho (cerca de 1100 insetos, e a mortalidade foi avaliada retirando-se e fazendo a contagem dos insetos mortos nos recipientes 10, 20 e 30 dias após a infestação. Este procedimento repetiu-se com 80, 160, 240, 320 e 400 dias após a aplicação de TD. Para avaliação da repelência foram utilizadas bandejas plásticas com (36×24×6 cm C×L×A, contendo 5 cm de cama de aviário tratada e não-tratada com TD (200g/m2 em metade de cada bandeja. Foram liberados 13g de adultos de cascudinho na linha de divisão dos

  5. Produção de matéria seca e eficiência nutricional para P, Ca e Mg em leguminosas herbáceas Dry matter production and nutritional efficiency for P, Ca and Mg in herbaceous legumes

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    Antonio Rodrigues Fernandes

    2007-06-01

    Full Text Available As leguminosas para adubação verde têm sido introduzidas nos sistemas agrícolas para a recuperação de solos desgastados pelo uso intensivo. O objetivo desse trabalho foi avaliar a resposta de leguminosas herbáceas à aplicação de calcário e fósforo sobre a produção de biomassa e eficiência nutricional para o P, Ca e Mg. O experimento foi desenvolvido em casa-de-vegetação do Departamento de Ciência do Solo da Universidade Federal Rural da Amazônia, utilizando-se um Latossolo Amarelo distrófico coletado na profundidade de 0 - 20 cm, em Belém, PA. O delineamento experimental usado foi o de blocos ao acaso, com arranjo de tratamentos em um fatorial 3³, onde foram comparadas três espécies de leguminosas: mucuna preta (Stizolobium atterrimum, mucuna cochinchinensis (Stilozobium cochinchinensis e feijão-de-porco (Canavalia ensiformes; três níveis de calagem: de calcário dolomítico (0, 4 e 8 t.ha-1 e de fósforo (0, 25 e 45 mg.dm-3, com quatro repetições cada um. Mucuna cochinchinensis e o feijão de porco produziram maiores quantidades de biomassa vegetal do que a mucuna preta, sendo que a primeira espécie acumulou maior quantidade de P e a segunda maior quantidade de Ca. Mucuna cochinchinensis apresentou maior eficiência de utilização de P, Ca e Mg na ausência da calagem. Nos solos intemperizados com baixa concentração de P, Ca e Mg, o feijão-de-porco e a mucuna cochinchinensis poderão ter melhor desempenho do que a mucuna preta, visto que apresentaram maior eficiência de translocação e de utilização desses nutrientes, respectivamente.The legumes used for green manure have been introduced in agricultural systems for recovering degraded soils by intensive use. The objective of this work was to evaluate the response of herbaceous legumes to liming and P application on dry matter and its nutritional efficiency. The experiment was developed in greenhouse at the Soil Science Department of the Federal University

  6. Utilização de cactáceas do gênero Pereskia na alimentação humana em um município de Minas Gerais Utilization of cacti of the genus Pereskia in the human diet in a municipality of Minas Gerais

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    Martha Elisa Ferreira de Almeida

    2012-04-01

    Full Text Available O objetivo deste trabalho foi avaliar a utilização de cactáceas do gênero Pereskia na alimentação humana. A pesquisa foi realizada nos 1.525 domicílios da cidade de São Gonçalo do Abaeté (MG. Nessa cidade, onde foi aplicado o questionário socioeconômico e quanto ao uso alimentar desta planta, comumente chamada de ora-pro-nóbis, somente 25 domicílios possuíam plantas do gênero Pereskia. Em 22 domicílios, havia a presença da Pereskia grandifolia, em três, havia a de Pereskia aculeata e, em um, havia os dois tipos. A presença de nutrientes na ora-pro-nobis foi citada por 83,33% dos entrevistados, sendo que 33,37% citaram um consumo mensal. A planta foi citada por 66,67% dos entrevistados como importante no tratamento da anemia ferropriva, por 16,67%, como agente terapêutico para o câncer, por 12,50%, para prevenção ou tratamento da osteoporose e, por 8,33%, para o tratamento da constipação intestinal. A classificação da ora-pro-nobis na categoria das hortaliças foi citada por 54,17% dos entrevistados. Concluiu-se que o resgate cultural do consumo desse tipo de planta poderá melhorar a condição nutricional e de renda das pessoas menos favorecidas economicamente, tanto no ambiente urbano quanto rural, de diferentes regiões do Brasil.The objective of this study was to evaluate the use of cacti of the genus Pereskia, for human consumption food. The study was conducted in 1.525 households in the city of São Gonçalo do Abaeté (MG. In this city where the socioeconomic questionnaire was applied regarding the dietary use of this plant, commonly referred to as ora-pro-nobis, only 25 of the households possessed plants of the genus Pereskia. In 22 households there was the presence of Pereskia grandifolia, in three households there was Pereskia aculeata, and one had both types. The presence of nutrients in the ora-pro-nobis was cited by 83.33% of respondents, where 33.37% cited monthly consumption. The plant was cited by 66

  7. Control biológico de enfermedades mediante el tratamiento de semillas de cucurbitáceas con rizobacterias promotoras del crecimiento de las plantas (PGPR./Biological control of diseases by cucurbits seeds treatment with rhizobacteria plant growth promoting (PGPR.

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    Gilda Jiménez Montejo

    2014-01-01

    Full Text Available Resumen:Las regulaciones sobre la producción de alimentos sanos limitan actualmente el uso de fungicidas sintéticos para el tratamiento de semillas y, por otra parte, no se dispone de bactericidas efectivos. Se condujeron experimentos en condiciones controladas para evaluar el efecto de las cepas de rizobacterias antagonistas Bacillus subtilis F16/95, B. subtilis Xph y Pseudomonas putida 14A en el control biológico de la Mancha bacteriana de las cucurbitáceas, la Mancha bacteriana del fruto de melón y la pudrición de la raíz, provocadas por Xanthomonas cucurbitae, Acidovorax avenae subsp. citrulli y Fusarium oxysporum, respectivamente. Se realizó el tratamiento de semillas de pepino (C. sativus, L. var. Poinsett, calabaza (Cucurbita moschata, Duch. var. INIVIT C-88, y melón de Castilla (Cucumis melo, L. var. Hale’s Best. Los tratamientos biológicos mostraron una reducción en la incidencia de las enfermedades e incrementos de longitud del tallo y peso fresco de hojas y raíces, en todas las interacciones planta-patógeno-antagonista. La colonización de raíces alcanzó rangos de 8,9-8,0 y 7,8-7,0 log (ufc cm-1 de raíz a los 4 y 15 días después de la siembra. Estos resultados caracterizaron las cepas aplicadas como rizobacterias promotoras del crecimiento vegetal (PGPR y aconsejan la realización de ensayos de campo./Abstract:Nowadays the regulations about the production of healthy foods limit the use of synthetic fungicides for seeds treatment and, on the other hand, effective bactericides are not available. Experiments under controlled conditions were conducted to evaluate the effect of rhizobacterial antagonistic strains Bacillus subtilis F16/95, B. subtilis Xph and Pseudomonas putida 14A on the biological control of Cucurbits bacterial spot, Watermelon bacterial fruit blotch and Fusarium root rot caused by Xanthomonas cucurbitae, Acidovorax avenae subsp. citrulli and Fusarium oxysporum, respectively. Cucumber (Cucumis sativus

  8. Riqueza de espécies e distribuição geográfica de amebas testáceas (Rhizopoda em ambientes aquáticos continentais brasileiros - DOI: 10.4025/actascibiolsci.v29i2.525 Species richness and geographic distribution of testate amoebae (Rhizopoda in Brazilian freshwater environments

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    Leandro Junio Fulone

    2007-12-01

    Full Text Available Este trabalho visa realizar um levantamento da riqueza de espécies de amebas testáceas, bem como descrever a distribuição geográfica e a distribuição em diferentes tipos de habitats desses organismos em ambientes aquáticos continentais brasileiros. Até o momento, são registrados 346 táxons infragenéricos, pertencentes a 13 famílias e 40 gêneros. São registrados 267 táxons na região centro-oeste, 188 táxons na região sudeste, 129 táxons na região sul, 53 táxons na região norte e 18 táxons na região nordeste. São registrados 282 táxons no plâncton; 131 táxons em macrófitas aquáticas, 81 táxons no sedimento e 73 táxons em musgos/esfágnos. Os resultados sobre a riqueza de tecamebas não é ainda conclusiva, visto que a maioria das pesquisas foi conduzida nas regiões centro-oeste, sudeste e sul. O maior número de táxons registrados no plâncton pode ser em virtude de que a maioria dos estudos sobre tecamebas, no Brasil, ter sido realizada no compartimento planctônico, incluindo reservatórios, lagoas de várzeas, canais, tributários e rios. Além disso, a maior parte dos estudos, em amostras de sedimento, foi conduzida em estuários ou lagoas costeiras, onde a salinidade é um fator limitante para a ocorrência desses organismos.The present study aimed to analyze the species richness of testate amoebae, as well as to describe their geographic distribution and different habitat types in Brazilian freshwater environments. Until now, 346 infrageneric taxa have been recorded, belonging to 13 families and 40 genera. In the Center-West region, 267 taxa were recorded; 188 taxa in the Southeast; 129 taxa in the South, 53 taxa in the North; and 18 taxa in Northeast region. A total of 282 taxa were recorded in plankton; 80 taxa in aquatic macrophytes; 81 taxa in sediment; and 73 taxa in moss/sphagnum. The results regarding testate amoebae species richness are not yet conclusive, given that most research on these organisms

  9. Análise química em órgãos de reserva de algumas herbáceas e arbóreas ocorrentes na flora do Espírito Santo, Brasil Chemical analysis of storage organs in herb and tree species from Espírito Santo State, Brazil

    Directory of Open Access Journals (Sweden)

    Joscineia Kelli Clippel

    2008-12-01

    Full Text Available Foi investigada a composição de carboidratos não estruturais em órgãos subterrâneos de reserva das herbáceas Dioscorea sp. 1 e Dioscorea sp. 2 (Dioscoreaceae, Hedychium coronarium J. König (Zingiberaceae, Hippeastrum reticulatum (L'Hérit. Herb. (Amaryllidaceae, Scadoxus multiflorus (Martyn Raf. (Amaryllidaceae, Prescottia nivalis Barb. Rodr. (Orchidaceae e Sinningia aghensis Chautems (Gesneriaceae. O trabalho objetivou, também, avaliar os teores dos polissacarídeos de reserva de parede celular (PRPC e de nutrientes minerais em sementes de Cassia fistula L., Cassia grandis L.f., Canavalia rosea (Sw. DC., Erythrina variegata L., Hymenaea courbaril L. e Ormosia arborea (Vell. Harms pertencentes à família Leguminosae. A espécie que apresentou maior conteúdo de frutose foi a bulbosa H. reticulatum (25% MS sugerindo a presença de frutanos em seus órgãos subterrâneos. Os maiores teores de carboidratos solúveis totais, especialmente a sacarose (63% MS, foram observados em rizomas de P. nivalis, indicando que esse carboidrato desempenhe papel osmorregulador nessa rupestre revivescente. Quanto aos polissacarídeos de reserva de parede celular, maiores valores foram encontrados em sementes de H. courbaril (70% MS, C. grandis (53% MS e C. rosea (40% de MS. Valores intermediários foram obtidos em C. fistula (24% de MS e E. variegata (11% MS. Sementes de O. arborea mostraram os mais baixos teores de PRPC não ultrapassando ao valor de 3% da MS. Trabalhos anteriores denotam que o polissacarídeo de reserva de H. courbaril é do tipo xiloglucano, enquanto o de C. grandis, C. fistula e C. rosea seja do tipo galactomanano. A identificação do tipo de polissacarídeo de E. variegata e de O. arborea depende de análises futuras através da cromatografia líquida de alta eficiência. Dos nutrientes minerais, sementes de C. rosea e E. variegata destacaram pelos elevados teores de N (60 g.kg-1 entre os macronutrientes e de Fe (160-170 mg.g-1 e Zn

  10. Fontes de resistência em melancia aos principais potyvírus isolados de cucurbitáceas no Nordeste brasileiro Sources of resistance in watermelon to the main cucurbit potyvírus isolated in the Northeast of Brazil

    Directory of Open Access Journals (Sweden)

    Vanuzia B. de Oliveira

    2002-12-01

    Full Text Available A melancia, Citrullus spp., pode ser infetada por várias espécies de vírus, dentre as quais se destacam as pertencentes à família Potyviridae. Visando identificar fontes de resistência a potyvírus, foi iniciado na UFC um programa de indexação do banco de germoplasma de melancia da Embrapa Semi-Árido. Foram utilizadas as espécies de potyvírus, isoladas de cucurbitáceas no Nordeste: Papaya ringspot virus type W (PRSV-W; Watermelon mosaic virus-2 (WMV-2 e Zucchini yellow mosaic virus (ZYMV. Dos 50 acessos de melancia avaliados, 37 pertencem a Citrullus lanatus, 9 a C. lanatus var. citroides e 4 a C. colocynthis. Em casa-de-vegetação foram inoculadas 4 plantas envasadas de cada acesso com PRSV-W, 4 com WMV-2 e 4 com ZYMV, ficando 4 sem inoculação. As inoculações foram efetuadas 8 dias após o plantio, e 15 dias depois. As plantas assintomáticas foram reinoculadas. As plantas que persistiram sem sintomas, após um período de 25 dias após a primeira inoculação, foram testadas por ELISA contra os anti-soros correspondentes. Dentre os acessos avaliados, 5 mostraram-se resistentes aos 3 vírus, um resistente somente ao PRSV-W, 21 resistentes somente ao ZYMV e nenhum com resistência isolada ao WMV-2. No entanto, 45 acessos apresentaram resistência ao ZYMV isoladamente ou em combinação com outro potyvírus. Os acessos suscetíveis, apresentaram sintomas 10 dias após a primeira inoculação enquanto que os resistentes permaneceram sem sintomas após a segunda inoculação e com resultados negativos em ELISA. Alguns acessos poderão ser cruzados visando obter populações segregantes para a seleção de indivíduos homozigotos recessivos e, juntamente com os acessos com resistência tripla identificados, ampliar a variabilidade genética de fontes quanto a características de planta e fruto.The watermelon, Citrullus spp., can be infected by several virus species from the Potyviridae family. In the Universidade Federal do Cear

  11. Polissacarídeos sulfatados isolados das clorofíceas Caulerpa racemosa e Caulerpa cupressoides – extração, fracionamento e atividade anticoagulante - doi: 10.4025/actascibiolsci.v32i2.5923 Sulfated polysaccharides isolated from Caulerpa racemosa and Caulerpa cupressoides (Chlorophyceaes – extraction, fractionation and anticoagulant activity - doi: 10.4025/actascibiolsci.v32i2.5923

    Directory of Open Access Journals (Sweden)

    Norma Maria Barros Benevides

    2010-05-01

    Full Text Available A incidência de doenças cardiovasculares e os efeitos adversos da heparinoterapia têm motivado a busca por novos agentes terapêuticos e os polissacarídeos sulfatados (PS de algas marinhas têm sido reportados como fontes alternativas para tal. Objetivou-se avaliar o potencial anticoagulante dos PS totais (PST isolados e fracionados das clorofíceas Caulerpa racemosa e Caulerpa cupressoides. Inicialmente, os PST foram extraídos com papaína em tampão acetato de sódio 0,1 M (pH 5,0 contendo cisteína 5 mM e EDTA 5 mM, seguidos de fracionamento em coluna de troca iônica de DEAE-celulose com gradiente de NaCl. As frações obtidas foram analisadas por eletroforese em gel de agarose a 0,5% e a atividade anticoagulante, mensurada pelo tempo de tromboplastina parcial ativada (TTPA, usando-se plasma humano normal e comparada a uma curva-padrão de heparina (193 UI mg-1. Verificaram-se semelhantes perfis cromatográficos entre os PS de ambas as espécies, porém com padrões de mobilidades distintas quando as frações foram comparadas por eletroforese. Os PS modificaram o TTPA, cujas atividades anticoagulantes foram de apenas 21,23 e 24,36 UI mg-1, quando eluídos com 0,75 M de sal para C. racemosa e C. cupressoides, respectivamente. Portanto, PS anticoagulantes isolados das clorofíceas C. racemosa e C. cupressoides resultaram em efeitos anticoagulantes inferiores aos da heparina. Estudos comparativos dessas moléculas também são sugeridos como ferramentas auxiliares na identificação de algas do mesmo gênero.The incidence of cardiovascular diseases and adverse effects from heparintherapy have led to a search for new therapeutic agents, and the sulfated polysaccharides (SP of seaweeds have been reported as alternative sources. The aim of this work was to evaluate the anticoagulant potential of total SP (TSP isolated and fractionated from Caulerpa racemosa and Caulerpa cupressoides (Chlorophyceaes. Initially, the TSP were extracted with

  12. Third session: new projects; Session 3: Les Projets nouveaux

    Energy Technology Data Exchange (ETDEWEB)

    Iracane, D. [CEA Saclay, Dir. de l' Energie Nucleaire (DEN), 91 - Gif sur Yvette (France); Dupuy, J.P. [AREVA-Technicatome, 13 - Aix en Provence (France); Perotto, G. [AREVA-Framatome-ANP, 13 - Aix en Provence (France); Ithurralde, G. [Electricite de France (EDF), 13 - Aix en Provence (France); Cabrillat, J.C. [CEA Cadarache, Dir. de l' Energie Nucleaire (DEN), 13 - Saint-Paul-lez-Durance (France); Becle, D. [FRAMATOME, AREVA-FANP, 69 - Lyon (France); Pivet, S. [CEA Bruyeres-le-Chatel, 91 (France); Minguet, J.L. [AREVA-Technicatome, 75 - Paris (France)

    2005-07-01

    The RJH (Jules Horowitz reactor) is a 100 MWth research reactor, cooled and moderated by water, that has been designed to operate with high density (8 g U/cm{sup 3}) and low enrichment fuel (19.75%) uranium molybdenum fuel. Its main neutron performances are expected to be: -) maximum fast neutron flux (E > 0.907 MeV) in the sample: 5.10{sup 14} n/cm{sup 2}/s, -) maximum thermal neutron flux (E < 0.625 eV): 4.10{sup 14} n/cm{sup 2}/s, and -) maximal neutron damage: 16 dpa/year. RJH that will be built on the Cea's site of Cadarache, is scheduled to enter into service in 2014, it will take over the activities of the Osiris reactor and its operating life is planned to be over 50 years long. The Cabri research reactor is located on the Cadarache site, it has been operating since 1962 and is now undergoing important upgrading operations whose aim is to make the facility fit to study the behaviour of new nuclear fuels in accidental situations. The RES test reactor is a facility whose aim is to qualify nuclear fuels and core configurations of existing propulsion reactors onboard of aircraft carriers or submarines and to propose innovative concepts for future propulsion reactors. (A.C.)

  13. Status of MOX core physics experiments: MISTRAL and analysis

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Toru [Nuclear Power Engineering Corp., Tokyo (Japan)

    1999-12-01

    Nuclear Power Engineering Corporation (NUPEC) has been studying advanced MOX LWR core concepts that give higher plutonium consumption rate and use plutonium effectively. This study is entrusted by the Japanese Ministry of International Trade and Industry (MITI). For this purpose, NUPEC has been working on the cores with higher moderation ratio than the conventional ones based on ALWRs (ABWR and APWR). A MOX core physics experiment program, MISTRAL, aims to obtain the basic core parameters of high moderation MOX cores. It was started from 1996 at a light water critical assembly, EOLE, at the Cadarache research center in the collaboration of NUPEC, CEA/DRN and CEA's industrial partners. The experiments consist of one UO{sub 2} and three MOX core configurations. In addition to these new data, NUPEC has obtained a part of the data of the MOX core physics experiment, EPICURE, which CEA had conducted before the MISTRAL. The analysis of those data is progressing with the SRAC system and the MVP Monte-Carlo code coupled by the JENDL3.2 library. (author)

  14. System and safety studies of accelerator driven transmutation systems

    Energy Technology Data Exchange (ETDEWEB)

    Gudowski, W.; Wallenius, J.; Tucek, K.; Eriksson, Marcus; Carlsson, Johan; Seltborg, P.; Cetnar, J. [Royal Inst. of Technology, Stockholm (Sweden). Dept. of Nuclear and Reactor Physics

    2001-05-01

    The research on safety of Accelerator-Driven Transmutation Systems (ADS) at the department has been focused on: a) ADS core design and development of advanced nuclear fuel optimised for high transmutation rates and good safety features; b) analysis of ADS-dynamics c) computer code and nuclear data development relevant for simulation and optimization of ADS; d) participation in ADS experiments including 1 MW spallation target manufacturing, subcritical experiments MUSE (CEA-Cadarache). Moreover, during the reporting period the EU-project 'IABAT', co-ordinated by the department has been finished and 4 other projects have been initiated in the frame of the 5th European Framework Programme. Most of the research topics reported in this paper are referred to appendices, which have been published in the open literature. The topics, which are not yet published, are described here in more details.

  15. Thermal-hydraulic analysis of LTS cables for the DEMO TF coil using simplified models

    Directory of Open Access Journals (Sweden)

    Lewandowska Monika

    2017-03-01

    Full Text Available The conceptual design activities for the DEMOnstration reactor (DEMO – the prototype fusion power plant – are conducted in Europe by the EUROfusion Consortium. In 2015, three design concepts of the DEMO toroidal field (TF coil were proposed by Swiss Plasma Center (EPFL-SPC, PSI Villigen, Italian National Agency for New Technologies (ENEA Frascati, and Atomic Energy and Alternative Energies Commission (CEA Cadarache. The proposed conductor designs were subjected to complete mechanical, electromagnetic, and thermal-hydraulic analyses. The present study is focused on the thermal-hydraulic analysis of the candidate conductor designs using simplified models. It includes (a hydraulic analysis, (b heat removal analysis, and (c assessment of the maximum temperature and the maximum pressure in each conductor during quench. The performed analysis, aimed at verification whether the proposed design concepts fulfil the established acceptance criteria, provides the information for further improvements of the coil and conductors design.

  16. Multi-domain/multi-method numerical approach for neutron transport equation; Couplage de methodes et decomposition de domaine pour la resolution de l'equation du transport des neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Girardi, E

    2004-12-15

    A new methodology for the solution of the neutron transport equation, based on domain decomposition has been developed. This approach allows us to employ different numerical methods together for a whole core calculation: a variational nodal method, a discrete ordinate nodal method and a method of characteristics. These new developments authorize the use of independent spatial and angular expansion, non-conformal Cartesian and unstructured meshes for each sub-domain, introducing a flexibility of modeling which is not allowed in today available codes. The effectiveness of our multi-domain/multi-method approach has been tested on several configurations. Among them, one particular application: the benchmark model of the Phebus experimental facility at Cea-Cadarache, shows why this new methodology is relevant to problems with strong local heterogeneities. This comparison has showed that the decomposition method brings more accuracy all along with an important reduction of the computer time.

  17. Scientists from all over the world attend the ''Frederic Joliot/Otto Hahn Summer School 2009'' at the Karlsruhe Institute of Technology (KIT); Wissenschaftler aus aller Welt bei der ''Frederic Joliot/Otto Hahn Summer School 2009'' am Karlsruhe Institute of Technologie (KIT)

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez Espinoza, Victor Hugo; Fischer, Ulrich [Karlsruhe Inst. of Tech. (KIT), Campus Nord/Inst. for Neutron Physics and Reactor Tech. (INR), Eggenstein-Leopoldshafen (Germany)

    2009-11-15

    The ''Frederic Joliot/Otto Hahn Summer School'' is organized each year alternately by the Karlsruhe Institute of Technology and the Commissariat a l'Energie Atomique (CEA), Cadarache. This year's Summer School, the 15th since its foundation, was run at the Advanced Training Center (FTU) of KIT Campus Nord on August 26 to September 4. The key topic this year was ''The Challenges in Implementing Fast Reactor Technology.'' These are the items discussed: Principles and challenges of future fast reactor designs, Fuels, fuel cycle, and recycling of minor actinides, Innovative cladding tube and structural materials, Special aspects of coolants and the challenges they pose, Fast reactor safety. Experts from 8 leading international research establishments and universities presented and discussed with the 58 participants from 16 countries the current state of the art and the latest development trends in the topics listed above. (orig.)

  18. System and safety studies of accelerator driven transmutation. Annual Report 2001

    Energy Technology Data Exchange (ETDEWEB)

    Gudowski, W.; Wallenius, J.; Tucek, K.; Eriksson, Marcus; Carlsson, Johan; Seltborg, P.; Cetnar, J.; Chakarova, R.; Westlen, D. [Royal Inst. of Tech., Stockholm (Sweden). Dept. of Nuclear and Reactor Physics

    2002-03-01

    The research on safety of Accelerator-Driven Transmutation Systems (ADS) at the Dept. of Nuclear and Reactor Physics has been focused in year 2001 on: a) ADS core design and development of advanced nuclear fuel optimised for high transmutation rates and good safety features; b) analysis of ADS-dynamics; c) computer code and nuclear data development relevant for simulation and optimization of ADS; d) participation in ADS experiments including 1 MW spallation target manufacturing, subcritical experiments MUSE (CEA-Cadarache) and YALINA experiment in Minsk. The Dept. is very actively participating in many European projects in the 5th Framework Programme of the European Community. Most of the research topics reported in this paper are referred to by appendices, which have been published in the open literature. The topics, which are not yet published, are described here in more details.

  19. Contribution of prototypic material tests on the Plinius platform to the study of nuclear reactor severe accident; Contribution des essais en materiaux prototypiques sur la plate-forme Plinius a l'etude des accidents graves de reacteurs nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Journeau, Ch

    2008-01-15

    The PLINIUS experimental platform at CEA Cadarache is dedicated to the experimental study of nuclear reactor severe accidents thanks to experiments between 2000 and 3500 K with prototypic corium. Corium is the mixture that would be formed by an hypothetical core melting and its mixing with structural materials. Prototypical corium has the same chemical composition as the corium corresponding to a given accident scenario but has a different isotopic composition (use of depleted uranium,...). Research programs and test series have been performed to study corium thermophysical properties, fission product behaviour, corium spreading, solidification and interaction with concrete as well as its coolability. It was the frame of research training of many students and was realized within national, European and international collaborations. (author)

  20. The bulk shielding benchmark experiment at the Frascati Neutron Generator (FNG)

    Energy Technology Data Exchange (ETDEWEB)

    Batistoni, P. [Associazione EURATOM-ENEA sulla Fusione, Frascati (Italy); Angelone, M. [Associazione EURATOM-ENEA sulla Fusione, Frascati (Italy); Martone, M. [Associazione EURATOM-ENEA sulla Fusione, Frascati (Italy); Pillon, M. [Associazione EURATOM-ENEA sulla Fusione, Frascati (Italy); Rado, V. [Associazione EURATOM-ENEA sulla Fusione, Frascati (Italy); Santamarina, A. [Commissariat al`Energie Atomique, Centre d`Etudes de Cadarache, F-13108 St. Paul-lez-Durance Cedex (France); Abidi, I. [Commissariat al`Energie Atomique, Centre d`Etudes de Cadarache, F-13108 St. Paul-lez-Durance Cedex (France); Gastaldi, B. [Commissariat al`Energie Atomique, Centre d`Etudes de Cadarache, F-13108 St. Paul-lez-Durance Cedex (France); Martini, M. [Commissariat al`Energie Atomique, Centre d`Etudes de Cadarache, F-13108 St. Paul-lez-Durance Cedex (France); Marquette, J.P. [Commissariat al`Energie Atomique, Centre d`Etudes de Cadarache, F-13108 St. Paul-lez-Durance Cedex (France)

    1995-03-01

    In the design of next-step fusion devices such as NET/ITER the nuclear performance of shielding blankets is of key importance in terms of nuclear heating of superconducting magnets and radiation damage. In the framework of the European Fusion Technology Program, ENEA Frascati and CEA Cadarache in collaboration performed a bulk shielding benchmark experiment using the 14MeV Frascati Neutron Generator (FNG), aimed at obtaining accurate experimental data for improving the nuclear database and methods used in shielding designs. The experiment consisted of the irradiation of a stainless steel block by 14MeV neutrons. The neutron reaction rates at various depths inside the block have been measured using fission chambers and activation foils characterized by different energy response ranges. The experimental results have been compared with numerical results calculated using both S{sub n} and Monte Carlo transport codes and the cross-section library EFF.1 (European Fusion File). (orig.).

  1. The Muse-4 experiment: measurement of the kinetic parameters of a subcritical system; L'experience MUSE-4: mesure des parametres cinetiques d'un systeme sous-critique

    Energy Technology Data Exchange (ETDEWEB)

    Vollaire, J

    2004-10-01

    Accelerator Driven Systems (ADS) which are based on an external neutron source coupled to a subcritical core, offer advantages for the incineration of radioactive waste. In order to understand the neutronic specificity of such a system, during the MUSE IV experimental program, the experimental reactor MASURCA (CEA Cadarache) has been coupled to the neutrons source GENEPI. This setup has enabled the development of an on-line measurement technique of the effective multiplication factor. This measurement benefits from the characteristics of the reactor response depending on the multiplication factor at the prompt fission and delayed fission time scales. The analysis of those experiments shows that the proposed method give results in agreement with the one deduced using classical reactivity measurement techniques which can not however be used in a power ADS. (author)

  2. Jules Horowitz Reactor, basic design

    Energy Technology Data Exchange (ETDEWEB)

    Bergamaschi, Y.; Bouilloux, Y.; Chantoin, P.; Guigon, B.; Bravo, X.; Germain, C.; Rommens, M.; Tremodeux, P

    2003-07-01

    Since the shutdown of the SILOE reactor in 1997, the OSIRIS reactor has ensured the needs regarding technological irradiation at CEA including those of its industrial partners and customers. The Jules Horowitz Reactor will replace it. It has the ambition to provide the necessary nuclear data and maintain a fission research capacity in Europe after 2010. This capacity should be service-oriented. It will be established in Cadarache. The Jules Horowitz reactor will also: - represent a significant step in term of performances and experimental capabilities, - be designed with a high flexibility, in order to satisfy the current demand from European industry, research and be able to accommodate future requirements, - reach a high level of safety, according to the best current practice. This paper will present the main functionalities and the design options resulting from the 'preliminary design' studies. (authors)

  3. OSMOSE program : statistical review of oscillation measurements in the MINERVE reactor R1-UO2 configuration.

    Energy Technology Data Exchange (ETDEWEB)

    Stoven, G.; Klann, R.; Zhong, Z.; Nuclear Engineering Division

    2007-08-28

    The OSMOSE program is a collaboration on reactor physics experiments between the United States Department of Energy and the France Commissariat Energie Atomique. At the working level, it is a collaborative effort between the Argonne National Laboratory and the CEA Cadarache Research Center. The objective of this program is to measure very accurate integral reaction rates in representative spectra for the actinides important to future nuclear system designs, and to provide the experimental data for improving the basic nuclear data files. The main outcome of the OSMOSE measurement program will be an experimental database of reactivity-worth measurements in different neutron spectra for the heavy nuclides. This database can then be used as a benchmark to verify and validate reactor analysis codes. The OSMOSE program (Oscillation in Minerve of isotopes in Eupraxic Spectra) aims at improving neutronic predictions of advanced nuclear fuels through oscillation measurements in the MINERVE facility on samples containing the following separated actinides: {sup 232}Th, {sup 233}U, {sup 234}U, {sup 235}U, {sup 236}U, {sup 238}U, {sup 237}Np, {sup 238}Pu, {sup 239}Pu, {sup 240}Pu, {sup 241}Pu, {sup 242}Pu, {sup 241}Am, {sup 243}Am, {sup 244}Cm, and {sup 245}Cm. The first part of this report provides an overview of the experimental protocol and the typical processing of a series of experimental results which is currently performed at CEA-Cadarache. In the second part of the report, improvements to this technique are presented, as well as the program that was created to process oscillation measurement results from the MINERVE facility in the future.

  4. Fusion technology annual report of the association EURATOM/CEA 1998; Technologie de la fusion Rapport annuel 1998 Association EURATOM/CEA 1998

    Energy Technology Data Exchange (ETDEWEB)

    Magaud, P.; Le vagueres, F

    1998-07-01

    In this book are found technical and scientific papers on the main works carried out in the frame of the european program of fusion technology, during 1998. The presented activities are: plasma facing components, vacuum vessel and shield, magnets, remote handling, safety (short and long term), european blanket project (long term) with water cooled lithium lead and helium cooled pebble bed blanket, materials for fusion power plant, socio-economic research on fusion, plasma facing components, fuel cycle, inertial confinement. (A.L.B.)

  5. Database for long lived radionuclides (LLRN). CEA working group report; Base de donnees sur les radionucleides a vie longue (RNVL). Rapport du groupe de travail CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This report constitutes a data base for long lived radionuclides (with half lives ranging from 30 to 10{sup 14} years) presenting informations on seven different topics: 'Radioactive data' gathers fundamental data characterising radioactive properties of considered radionuclides (half-life, disintegration mode, radiation energy,...); 'Formation and inventory' collects data on radionuclide formation ways as well as quantities formed during fuel irradiation; 'Biological effects' gives data characterising both radiotoxicity for each radionuclide and chemical toxicity for the considered element; 'Partitioning' specifies element repartition according to the different ways of Purex reprocessing and complementary partitioning processes possible for isolating chemical elements corresponding to the considered radionuclides; 'Transmutation' provides data allowing in part to evaluate the feasibility and destruction performances of radionuclides by transmutation with neutrons; 'Behaviour in waste packages' gathers some data relative to the properties of waste packages confinement. Only data on vitrified waste packages are given there; 'Behaviour in diluted solution' provides data used for element migration calculations. (author)

  6. Risks control at the Cea: presentation of the third annual evaluation; Maitrise des risques au CEA: presentation du troisieme bilan annuel

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This presentation aims to define the main topics of the risks control which some evolutions occurred in 2005. It concerns the environmental impact, the occupational risks, the hazardous materials transport, the site and installations protection, the installation safety, the emergency situations and, the audits and the juridical protection. (A.L.B.)

  7. Reactivity effect breakdown calculations with deterministic and stochastic perturbations analysis - JEFF-3.1.1 to JEFF3.2T1 (BRC-2009) actinides application

    Science.gov (United States)

    Peneliau, Y.; Morillon, B.

    2013-03-01

    JEFF-3.1.1 is the reference nuclear data library in CEA for the design calculations of the next nuclear power plants. The validation of the new neutronics code systems is based on this library and changes in nuclear data should be looked at closely. Some new actinides evaluation files at high energies have been proposed by CEA/Bruyères-le-Chatel in 2009 and have been integrated in JEFF3.2T1 test release. For the new release JEFF-3.2, CEA will build new evaluation files for the actinides, which should be a combination of the new evaluated data coming from BRC-2009 in the high energy range and improvements or new evaluations in the resolved and unresolved resonance range from CEA-Cadarache. To prepare the building of these new files, benchmarking the BRC-2009 library in comparison with the JEFF-3.1.1 library was very important. The crucial points to evaluate were the improvements in the continuum range and the discrepancies in the resonance range. The present work presents for a selected set of benchmarks the discrepancies in the effective multiplication factor obtained while using the JEFF-3.1.1 or JEFF-3.2T1 library with the deterministic code package ERANOS/PARIS and the stochastic code TRIPOLI-4. They have both been used to calculate cross section perturbations or other nuclear data perturbations when possible. This has permittted to identify the origin of the discrepancies in reactivity calculations. In addition, this work also shows the importance of cross section processing validation. Actually, some fast neutron spectrum calculations have led to opposite tendancies between the deterministic code package and the stochastic code. Some particular nuclear data (MT=5 in ENDF terminology) seem to be incompatible with the current MERGE or GECCO processing codes.

  8. Contamination transfers during fuel transport cask loading. A concrete situation

    Energy Technology Data Exchange (ETDEWEB)

    Fournel, B.; Turchet, J.P.; Faure, S.; Allinei, P.G. [DEN/DED Centre d' Etudes de Cadarache, 13 - Saint Paul lez Durance (France); Briquet, L. [EDF GENV, 93 - Saint Denis (France); Baubet, D. [SGS Qualitest Industrie, 30 - Pont Saint Esprit (France)

    2002-07-01

    In 1998, a number of contamination cases detected during fuel shipments have been pointed out by the french nuclear safety authority. Wagon and casks external surfaces were partly contaminated upon arrival in Valognes railway terminal. Since then, measures taken by nuclear power plants operators in France and abroad solved the problem. In Germany, a report analyzing the situation in depth has been published in which correctives actions have been listed. In France, EDF launched a large cleanliness program (projet proprete radiologique) in order to better understand contamination transfers mechanisms during power plants exploitation and to list remediation actions to avoid further problems. In this context, CEA Department for Wastes Studies at Cadarache (CEA/DEN/DED) was in charge of a study about contamination transfers during fuel elements loading operations. It was decided to lead experiments for a concrete case. The loading of a transport cask at Tricastin-PWR-1 was followed in november 2000 and different analysis comprising water analysis and smear tests analysis were carried out and are detailed in this paper. Results are discussed and qualitatively compared to those obtained in Philippsburg-BWR, Germany for a similar set of tests. (authors)

  9. State of the art on nuclear heating measurement methods and expected improvements in zero power research reactors

    Directory of Open Access Journals (Sweden)

    Le Guillou Mael

    2017-01-01

    Full Text Available The paper focuses on the recent methodological advances suitable for nuclear heating measurements in zero power research reactors. This bibliographical work is part of an experimental approach currently in progress at CEA Cadarache, aiming at optimizing photon heating measurements in low-power research reactors. It provides an overview of the application fields of the most widely used detectors, namely thermoluminescent dosimeters (TLDs and optically stimulated luminescent dosimeters. Starting from the methodology currently implemented at CEA, the expected improvements relate to the experimental determination of the neutron component, which is a key point conditioning the accuracy of photon heating measurements in mixed n–γ field. A recently developed methodology based on the use of 7Li and 6Li-enriched TLDs, precalibrated both in photon and neutron fields, is a promising approach to deconvolute the two components of nuclear heating. We also investigate the different methods of optical fiber dosimetry, with a view to assess the feasibility of online photon heating measurements, whose primary benefit is to overcome constraints related to the withdrawal of dosimeters from the reactor immediately after irradiation. Moreover, a fibered setup could allow measuring the instantaneous dose rate during irradiation, as well as the delayed photon dose after reactor shutdown. Some insights from potential further developments are given. Obviously, any improvement of the technique has to lead to a measurement uncertainty at least equal to that of the currently used methodology (∼5% at 1σ.

  10. Analysis of LWR Full MOX Core Physics Experiments with Major Nuclear Data Libraries

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Toru [Japan Nuclear Energy Safety Organization, Tokyo (Japan)

    2007-07-01

    Nuclear Power Engineering Corporation (NUPEC) studied high moderation full MOX cores as a part of advanced LWR core concept studies from 1994 to 2003 supported by the Ministry of Economy, Trade and Industry. In order to obtain the major physics characteristics of such advanced MOX cores, NUPEC carried out core physics experimental programs called MISTRAL and BASALA from 1996 to 2002 in the EOLE critical facility of the Cadarache Center in collaboration with CEA. NUPEC also obtained a part of experimental data of the EPICURE program that CEA had conducted for 30 % Pu recycling in French PWRs. Japan Nuclear Energy Safety Organization(JNES) established in 2003 as an incorporated administrative agency took over the NUPEC's projects for nuclear regulation and has been implementing FUBILA program that is for high burn up BWR full MOX cores. This paper presents an outline of the programs and a summary of the analysis results of the criticality of those experimental cores with major nuclear data libraries.

  11. Visible and Infrared Optical Design for the ITER Upper Ports

    Energy Technology Data Exchange (ETDEWEB)

    Lasnier, C; Seppala, L; Morris, K; Groth, M; Fenstermacher, M; Allen, S; Synakowski, E; Ortiz, J

    2007-03-01

    This document contains the results of an optical design scoping study of visible-light and infrared optics for the ITER upper ports, performed by LLNL under contract for the US ITER Project Office. ITER is an international collaboration to build a large fusion energy tokamak with a goal of demonstrating net fusion power for pulses much longer than the energy confinement time. At the time of this report, six of the ITER upper ports are planned to each to contain a camera system for recording visible and infrared light, as well as other diagnostics. the performance specifications for the temporal and spatial resolution of this system are shown in the Section II, Functional Specifications. They acknowledge a debt to Y. Corre and co-authors of the CEA Cadarache report ''ITER wide-angle viewing and thermographic and visible system''. Several of the concepts used in this design are derived from that CEA report. The infrared spatial resolution for optics of this design is diffraction-limited by the size of the entrance aperture, at lower resolution than listed in the ITER diagnostic specifications. The size of the entrance aperture is a trade-off between spatial resolution, optics size in the port, and the location of relay optics. The signal-to-noise ratio allows operation at the specified time resolutions.

  12. Reversible high blood CEA and CA19-9 concentrations in a diabetic ...

    African Journals Online (AJOL)

    screening (1). Pancreatic cancer may cause diabetes by destroying islet cells, inducing pancreas inflammation, or causing peripheral resistance to insulin. ... with diabetes. The histology of pancreatic islets from type 2 diabetic patients was known to be associated with an inflammatory process, which also involved the ...

  13. Latest Developments of HgCdTe e-APDs at CEA LETI-Minatec

    Science.gov (United States)

    Rothman, Johan; Perrais, Gwladys; Ballet, Philippe; Mollard, L.; Gout, S.; Chamonal, J.-P.

    2008-09-01

    In this communication, we report on the electro-optical characterization of planar back-side-illuminated HgCdTe electron initiated avalanche photodiode (e-APD) test arrays with cut-off wavelengths λ c = 2.4 μm, λ c = 4.8 μm, and λ c = 9.2 μm. The e-APDs were manufactured at LETI using absorption layers grown by molecular beam epitaxy (MBE). We present measurements of the distributions in gain, noise, and equivalent input dark current. The mid-wave (MW) diodes yielded a very low dispersion (2%) and high operability (98%) for gains up to M = 200. The excess noise factor and equivalent input current ( I eq_in) operability were slightly lower, due to defects in the depletion region. The lowest measured value of I eq_in = 1 fA corresponds to the lowest level measured so far in HgCdTe e-APDs and opens the way to new applications. The gain in the long-wave (LW) diodes was limited by tunnelling currents to a value of M = 2.4, associated with an average noise factor F = 1.2. A gain of M = 20 at a bias of -22.5 V was demonstrated in the short-wave (SW) e-APDs.

  14. Nuevos fármacos inspirados en Annonáceas

    Directory of Open Access Journals (Sweden)

    Diego Cortes

    2014-01-01

    Full Text Available Los metabolitos secundarios activos (MSA juegan un papel importante en el descubrimiento de nuevos medicamentos. Moléculas naturales con esqueletos complejos, tales como las estatinas aisladas de Aspergillus terreus, o las acetogeninas específicas de la familia Annonaceae, no hubieran podido ser inventadas en ningún laboratorio. Los MSA aislados en Annonaceae, especialmente las acetogeninas y los alcaloides isoquinoleínicos, pueden ser considerados como fuente constante de inspiración para químicos, farmacólogos y para todos los investigadores interesados en el descubrimiento de una nueva familia de medicamentos.

  15. Dimensões das fibras em bambusáceas Fiber dimensions of bamboos

    Directory of Open Access Journals (Sweden)

    Júlio César Medina

    1962-01-01

    Full Text Available São apresentados e discutidos os resultados das medições de comprimento e largura das fibras de 27 espécies alienígenas de bambus, compreendendo 12 gêneros, das quais apenas 4 foram anteriormente estudados pelos autores. O material usado nos exames biométricos das fibras de 19 das novas espécies estudadas, foi coletado do "bambusetum" localizado na Estação Experimental de Tatuí, sendo que o dos 4 restantes do base do côlmo de mudos importadas do estrangeiro, mas que não vingaram. Os resultados dos medições mostram que as dimensões das fibras, em comprimento e largura, variaram grandemente segundo as espécies de bambu. O comprimento médio de fibra variou de 1,33 a 2,74 mm, enquanto que a largura variou de 8,39 a 20,90 microns. A relação entre o comprimento e a largura das fibras situou-se entre 63:1 a 264:1. Os resultados encontrados nas medições de comprimento das fibras confirmam, de modo geral, o valor dos bambus como matéria-prima para produção de celulose de fibras longas.This article gives fiber dimensions and derived values obtained for 23 bamboo species, besides similar data for 4 species previously reported by the authors. The average fiber dimensions found for the 27 bamboo species ranged as follows (in milimeters: length, from 1.325 for Bambusa beecheyana to 2.744 for Gigantcchloa apus; width, from 0.00839 for Pleioblastus simoni to 0.02090 for Bambusa beecheyana. The length diameter ratio ranged from 63:1 to 264:1, the shortest ratio being that of Bambusa beecheyana and the highest one of Bambusa vulgaris. The coefficient of variation for fiber length ranged from 26.50% to 42.32% and for fiber width from 17.80% to 60.09%. Considering the ease of bamboo cultivation, the high and rapid production per area, and the quality of the fiber, bamboos areunquestionably the most promising source for cellulose production in the tropical and subtropical regions. As in many other countries where bamboo is being used on a large scale for the pulp and paper industry, it seems likely that in Brazil this plant as a commercial crop will be, in very near future, an important source of long-fibered pulp for blending with short-fibered pulps in papermaking.

  16. ROIC development at CEA for SWIR detectors: pixel circuit architecture and trade-offs

    Science.gov (United States)

    Guellec, F.; Boulade, O.; Cervera, C.; Moreau, V.; Gravrand, O.; Rothman, J.; Zanatta, J.-P.

    2017-11-01

    Infrared detection is widely used in astrophysics and plays a key role in several space missions aiming for example at scanning the sky to discover new objects (coolest stars, dust-obscured galaxies, exo-planets …) or studying the evolution of the universe, where light is redshifted in the infrared range. In many cases the space telescope involves an HgCdTe infrared detector operating at low frame rate over long integration time. Due to the very low input signal, dark current and readout noise are essential figures that must be minimized to get the best detector sensitivity. This kind of application also requires very large focal plane array (FPA) often relying on a butting arrangement of large detectors. The trend is to increase the single detector format from 1Kx1K to 2Kx2K and 4Kx4K. For very large formats, material quality and detector process may affect the production yield and the global infrared FPA cost. As a result the detector format could result from a trade-off taking into account producibility.

  17. 77 FR 74283 - Clearing Requirement Determination Under Section 2(h) of the CEA

    Science.gov (United States)

    2012-12-13

    ... currency non-deliverable forwards to meet its proposed mandatory clearing criteria. Additional swaps will... credit default swaps (CDS) and interest rate swaps, described herein, be cleared by a derivatives... Comments C. Credit Default Swaps D. Determination Analysis for Credit Default Swaps E. Interest Rate Swaps...

  18. Mammalian Cell Culture Clarification: A Case Study Using Chimeric Anti-CEA Monoclonal Antibodies

    Directory of Open Access Journals (Sweden)

    Mohamed Ali Abol Hassan

    2011-12-01

    Full Text Available The extracellular expression of monoclonal antibodies (mAbs in mammalian cell culture provides both opportunities and restrictions for the design of robust harvest and clarification operations. With advances in cell culture media and cell lines, it is now possible to achieve high titers of over 5 g/l for mAbs. However, Mammalian cells are sensitive to breakage due to shear stress that can result in release of proteases and other host cell proteins (HCPs which eventually affects product stability and purity. There is larger number of mAbs undergoing clinical development and it has placed significant importance on platform technologies of process development. Generally, Centrifugation and microfiltration are the primary harvest techniques used in the industry and depth filtration is also used as a step operation on clarification. This study compares the unit operations; centrifugation, microfiltration and depth filtration for maximum recovery of monoclonal antibodies. The results have shown that the depth filtration as more suitable operation for mammalian cell culture clarification since it gives 96% recovery of mAbs in comparison to centrifugation and microfiltration. ABSTRAK: Pengungkapan luar sel dari antibodi monoklon (monoclonal antibodies ((mAbs dalam kultur sel mamalia memberi ruang dan batasan terhadap reka bentuk penuaian yang cekap dan penerangan operasi. Dengan kemajuan dalam media sel kultur dan cell lines (produk yang berupa sel kekal yang digunakan untuk tujuan kajian biologi, kini adalah berkemungkinan untuk memperolehi titer tinggi melebihi 5g/l untuk mAbs [2]. Walaupun begitu, sel mamalia sensitif terhadap retakan disebabkan tegasan ricih yang menyebabkan pengeluaran protease dan hos sel protein yang lain, (host cell proteins (HCPs akhirnya mempengaruhi kestabilan dan keaslian produk. Terdapat mAbs dalam jumlah besar yang masih menjalani pembangunan klinikal dan sesungguhnya ini penting sebagai satu landasan teknologi dalam proses pembangunan. Umumnya pengemparan dan mikropenurasan merupakan teknik asas tuaian dalam industri dan penurasan dalam juga digunakan sebagai satu pengendalian langkah dalam penjelasannya. Kajian ini membandingkan operasi unit: pengemparan, mikropenurasan dan penurasan dalam untuk perolehan antibodi monoklon yang maksima. Keputusan menunjukkan penurasan dalam adalah operasi yang lebih sesuai untuk penjelasan kultur sel mamalia kerana ia memberikan perolehan 96 % mAbs berbandingkan dengan cara pengemparan dan mikropenurasan.

  19. Diatomáceas no contexto da investigação das mortes por agogamento

    OpenAIRE

    Faria, Bruno Américo Cortesão

    2013-01-01

    Resumo A dificuldade na obtenção de um diagnóstico médico-legal de morte por afogamento representa ainda hoje um desafio para o patologista forense. Não obstante a evolução das leges artis, nomeadamente no que concerne a procedimentos e técnicas nas áreas da histologia e anatomia patológica, possibilitando conclusões sólidas acerca dos efeitos nos tecidos e a sua correlação com o afogamento, existem casos, na sua maioria resultantes da continuada permanência do corpo em m...

  20. NOVEDADES AXONÓMICAS DE LAS ERICÁCEAS DEL SUROCCIDENTE DE COLOMBIA

    Directory of Open Access Journals (Sweden)

    NELSON R. SALINAS

    2007-06-01

    Full Text Available Se proponen algunas novedades taxonómicas para la familia Ericaceae en el suroccidente colombiano. Se describe e ilustra Vaccinium singularis N. R. Salinas & Betancur, una especie nueva de la vertiente pacífica del departamento de Nariño. Por otra parte, se propone a Sphyrospermum boekei Luteyn como sinónimo de S. grandifolium (Hoerold A. C. Sm.

  1. Escala de Afrontamiento del Estrés Académico (A-CEA).

    OpenAIRE

    Isabel Piñeiro; Susana Rodríguez; Antonio Valle; Ramón G. Cabanach; María G. Gerpe

    2010-01-01

    Assuming that the effects of stressors on students´ health, cognitive functioning and wellbeing depends on the stressors and how these are addressed, this paper attempts to prove the validity of an instrument for the specific evaluation of the coping stress strategies of university students. This work is developed in two phases. For this purpose a bank of items bringing together different coping stress strategies were elaborated and a application with a sample of university students was carri...

  2. Una histórica Melastomatácea, nueva en la Flora de Colombia

    Directory of Open Access Journals (Sweden)

    Uribe Uribe Lorenzo

    1957-12-01

    Full Text Available EI Instituto de Ciencias Naturales de la Universidad Nacional ha procurado seguir con cariño y devoción las huellas que dejó, hace cerca de dos siglos, la gloriosa Real Expedición Botánica del Nuevo Reina de Granada (hoy Colombia, repitiendo sus excursiones, buscando sus plantas y eventualmente reivindicando para la ciencia nacional descubrimientos que ella no logró divulgar en su tiempo.  En años pasados una comisión de dos miembros del Instituto recorrió con éxito halagador, la región de La Mesa, primera sede de la Expedición, y pudo hallar muchos de los ejemplares que iniciaron la gran obra mutisiana. En Mariquita he tenido la fortuna, en diversas ocasiones, de coleccionar plantas que merecieron el interés y el estudio de Mutis y Valenzuela, y que fueron conmemoradas en sus diarios paralelos. Es halagador tender este puente ideal para unir los esfuerzos meritorios de aquellos dos sabios, iniciadores entre nosotros del estudio de la Naturaleza, con los nuestros que buscan seguir la misma ruta que ellos transitaron y exaltar su obra que honra a Colombia y constituye el primer capítulo de nuestra cultura científica.

  3. CEAS/AIAA/ICASE/NASA Langley International Forum on Aeroelasticity and Structural Dynamics 1999. Pt. 1

    Science.gov (United States)

    Woodrow Whitlow, Jr. (Editor); Todd, Emily N. (Editor)

    1999-01-01

    These proceedings represent a collection of the latest advances in aeroelasticity and structural dynamics from the world community. Research in the areas of unsteady aerodynamics and aeroelasticity, structural modeling and optimization, active control and adaptive structures, landing dynamics, certification and qualification, and validation testing are highlighted in the collection of papers. The wide range of results will lead to advances in the prediction and control of the structural response of aircraft and spacecraft.

  4. Las rubiáceas: no sólo café

    Directory of Open Access Journals (Sweden)

    Arturo Acero Pizarro

    2005-05-01

    Full Text Available Rubiacea de Colombia. Guía ilustrada de géneros. Humberto Mendoza, Bernardo R. Ramírez P. y Luis Carlos Jiménez. Editorial del libro reseñado: Instituto de Investigación de Recursos Biológicos Alexander von Humboldt, Bogotá, 2004, 351 págs.

  5. Acetogeninas de anonáceas isoladas de folhas de Rollinia laurifolia

    Directory of Open Access Journals (Sweden)

    Nascimento Francisco das Chagas do

    2003-01-01

    Full Text Available Phytochemical investigation of hexanic extract of leaves of Rollinia laurifolia afforded three known acetogenins, uvariamicin-I (1, solamin(2 and gonionenin(3, for the first time isolated from Rollinia genus. The structures of 1, 2 and 3 were elucidated by spectroscopic methods.

  6. Science and technology research and development in support to ITER and the Broader Approach at CEA

    Czech Academy of Sciences Publication Activity Database

    Bécoulet, A.; Hoang, G.T.; Abiteboul, J.; Achard, J.; Alarcon, T.; Alba-Duran, J.; Allegretti, L.; Allfrey, S.; Amiel, S.; Ané, J.M.; Aniel, T.; Antar, G.; Argouarch, A.; Armitano, A.; Arnaud, J.; Arranger, D.; Artaud, J.F.; Audisio, D.; Aumeunier, M.; Autissier, E.; Azcona, L.; Back, A.; Bahat, A.; Bai, X.; Baiocchi, B.; Balaguer, D.; Balme, S.; Balorin, C.; Barana, O.; Barbier, D.; Barbuti, A.; Basiuk, V.; Baulaigue, O.; Bayetti, P.; Baylard, B.; Beaufils, S.; Beaute, A.; Bécoulet, M.; Bej, Z.; Benkadda, S.; Benoit, F.; Berger-By, G.; Bernard, J.M.; Berne, A.; Bertrand, B.; Bertrand, E.; Beyer, P.; Bigand, A.; Bonhomme, G.; Borel, G.; Boron, A.; Bottereau, C.; Bottollier-Curtet, H.; Bouchand, C.; Bouquey, F.; Bourdelle, C.; Bourg, J.; Bourmaud, S.; Brémond, S.; Bribiesca Argomedo, F.; Brieu, M.; Brun, C.; Bruno, V.; Bucalossi, J.; Bufferand, H.; Buravand, Y.; Cai, L.; Cantone, V.; Cantone, B.; Caprin, E.; Cartier-Michaud, T.; Castagliolo, A.; Belo, J.; Catherine-Dumont, V.; Caulier, G.; Chaix, J.; Chantant, M.; Chatenet, M.; Chauvin, D.; Chenevois, J.; Chouli, B.; Christin, L.; Ciazynski, D.; Ciraolo, G.; Clairet, F.; Clapier, R.; Cloez, H.; Coatanea-Gouachet, M.; Colas, L.; Colledani, G.; Commin, L.; Coquillat, P.; Corbel, E.; Corre, Y.; Cottet, J.; Cottier, P.; Courtois, X.; Crest, I.; Dachicourt, R.; Dapena Febrer, M.; Daumas, C.; de Esch, H.P.L.; De Gentile, B.; Dechelle, C.; Decker, J.; Decool, P.; Deghaye, V.; Delaplanche, J.; Delchambre-Demoncheaux, E.; Delpech, L.; Desgranges, C.; Devynck, P.; Dias Pereira Bernardo, J.; Dif-Pradalier, G.; Doceul, L.; Dong, Y.; Douai, D.; Dougnac, H.; Dubuit, N.; Duchateau, J.-L.; Ducobu, L.; Dugue, B.; Dumas, N.; Dumont, R.; Durocher, A.; Durocher, A.; Duthoit, F.; Ekedahl, A.; Elbeze, D.; Escarguel, A.; Escop, J.; Fäisse, F.; Falchetto, G.; Farjon, J.; Faury, M.; Fedorzack, N.; Féjoz, P.; Fenzi, C.; Ferlay, F.; Fiet, P.; Firdaouss, M.; Francisquez, M.; Franel, B.; Frauche, J.; Frauel, Y.; Futtersack, R.; Garbet, X.; Garcia, J.; Gardarein, J.; Gargiulo, L.; Garibaldi, P.; Garin, P.; Garnier, D.; Gauthier, E.; Gaye, O.; Geraud, A.; Gerome, M.; Gervaise, V.; Geynet, M.; Ghendrih, P.; Giacalone, I.; Gibert, S.; Gil, C.; Ginoux, S.; Giovannangelo, L.; Girard, S.; Giruzzi, G.; Goletto, C.; Goncalves, R.; Gonde, R.; Goniche, M.; Goswami, R.; Grand, C.; Grandgirard, V.; Gravil, B.; Grisolia, C.; Gros, G.; Grosman, A.; Guigue, J.; Guilhem, D.; Guillemaut, C.; Guillerminet, B.; Guimaraes Filho, Z.; Guirlet, R.; Gunn, J. P.; Gurcan, O.; Guzman, F.; Hacquin, S.; Hariri, F.; Hasenbeck, F.; Hatchressian, J.C.; Hennequin, P.; Hernandez, C.; Hertout, P.; Heuraux, S.; Hillairet, J.; Honore, C.; Hornung, G.; Houry, M.; Hunstad, I.; Hutter, T.; Huynh, P.; Icard, V.; Imbeaux, F.; Irishkin, M.; Isoardi, L.; Jacquinot, J.; Jacquot, J.; Jiolat, G.; Joanny, M.; Joffrin, E.; Johner, E.; Joubert, P.; Jourd’Heuil, L.; Jouve, M.; Junique, C.; Keller, D.; Klepper, C.; Kogut, M.; Kubič, M.; Labassé, F.; Lacroix, B.; Lallier, Y.; Lamaison, V.; Lambert, R.; Larroque, S.; Latu, G.; Lausenaz, Y.; Laviron, C.; Le, R.; Le Luyer, A.; Le Niliot, C.; Le Tonqueze, Y.; Lebourg, P.; Lefevre, T.; Leroux, F.; Letellier, L.; Li, Y.; Lipa, M.; Lister, J.; Litaudon, X.; Liu, F.; Loarer, T.; Lombard, G.; Lotte, P.; Lozano, M.; Lucas, J.; Lütjens, H.; Magaud, P.; Maget, P.; Magne, R.; Mahieu, J.-F.; Maini, P.; Malard, P.; Manenc, L.; Marandet, Y.; Marbach, G.; Marechal, J.-L.; Marfisi, L.; Marle, M.; Martin, C.; Martin, V.; Martin, G.; Martinez, A.; Martino, P.; Masset, R.; Mazon, D.; Mellet, N.; Mercadier, L.; Merle, A.; Meshcheriakov, D.; Messina, P.; Meyer, O.; Millon, L.; Missirlian, M.; Moerel, J.; Molina, D.; Mollard, P.; Moncada, V.; Monier-Garbet, P.; Moreau, D.; Moreau, M.; Moreau, P.; Morel, P.; Moriyama, T.; Motassim, Y.; Mougeolle, G.; Moulton, D.; Moureau, G.; Mouyon, D.; Naim Habib, M.; Nardon, E.; Négrier, V.; Nemeth, J.; Nguyen, C.; Nguyen, M.; Nicolas, L.; Nicolas, T.; Nicollet, S.; Nilsson, E.; N’Konga, B.; Noel, F.; Nooman, A.; Norscini, C.; Nouailletas, R.; Oddon, P.; Ohsako, T.; Orain, F.; Ottaviani, M.; Pagano, M.; Palermo, F.; Panayotis, S.; Parrat, H.; Pascal, J.-Y.; Passeron, C.; Pastor, P.; Patterlini, J.; Pavy, K.; Pecquet, A.-L.; Pégourié, B.; Peinturier, C.; Pelletier, T.; Peluso, B.; Petržílka, Václav; Peysson, Y.; Pignoly, E.; Pirola, R.; Pocheau, C.; Poitevin, E.; Poli, V.; Poli, S.; Pompon, F.; Porchy, I.; Portafaix, C.; Preynas, M.; Prochet, P.; Prou, M.; Ratnani, A.; Raulin, D.; Ravenel, N.; Renard, S.; Ricaud, B.; Richou, M.; Ritz, G.; Roche, H.; Roubin, P.; Roux, C.; Ruiz, K.; Sabathier, F.; Sabot, R.; Saille, A.; Saint-Laurent, F.; Sakamoto, R.; Salasca, S.; Salmon, T.; Salmon, T.; Samaille, F.; Sanchez, S.; Santagiustina, A.; Saoutic, B.; Sarazin, Y.; Sardain, P.; Schlosser, J.; Schneider, M.; Schwob, J.; Segui, J.; Seguin, N.; Selig, G.; Serret, D.; Signoret, J.; Signoret, J.; Simonin, A.; Soldaini, M.; Soler, B.; Soltane, C.; Song, S.; Sourbier, F.; Sparagna, J.; Spitz, P.; Spuig, P.; Storelli, A.; Strugarek, A.; Tamain, P.; Tena, M.; Theis, J.; Thomine, O.; Thouvenin, D.; Torre, A.; Toulouse, L.; Travere, J.; Tsitrone, E.; Turck, B.; Urban, J.; Vallet, J.-C.; Vallory, J.; Valognes, A.; Van Helvoirt, J.; Vartanian, S.; Verger, J.-M.; Vermare, L.; Vermare, C.; Vezinet, D.; Vicente, K.; Vidal, J.; Vignal, N.; Vigne, T.; Villecroze, F.; Villedieu, E.; Vincent, B.; Volpe, B.; Volpe, D.; Volpe, R.; Wagrez, J.; Wang, H.; Wauters, T.; Wintersdorff, O.; Wittebol, E.; Zago, B.; Zani, L.; Zarzoso, D.; Zhang, Y.; Zhong, W.; Zou, X.L.

    2013-01-01

    Roč. 53, č. 10 (2013), s. 104023-104023 ISSN 0029-5515 Institutional support: RVO:61389021 Keywords : ITER * Tore Supra * system * plasma Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 3.243, year: 2013 http://iopscience.iop.org/0029-5515/53/10/104023/pdf/0029-5515_53_10_104023.pdf

  7. Rosácea, demodex folliculorum y metronidazol tópico

    Directory of Open Access Journals (Sweden)

    Héctor Castellanos Lorduy

    1998-10-01

    Full Text Available We present a study performed on 18 patient s with rosacea who underwent screening for D. foiliculoru m with the standarized skin surface biopsy before and after topical treatment with metronidazole. The mite counts were similar in the skin samples before and after topical metronidazole but higher than those observed in contra subjects matched for age and sex. We concluded that the mite is not the primary pathogen involved in rosacea, but its role as vector of a patogenic bacteria must be investigated.

  8. Analysis of the corium phases by X-ray diffraction; Analyses des phases du corium par diffraction des rayons X

    Energy Technology Data Exchange (ETDEWEB)

    Trillon, G

    2004-07-01

    In the framework of the severe accidents R and D studies led by CEA, the better knowledge of the corium behaviour, corium coming from the melting of a nuclear reactor, are fundamental stakes in order to master this kind of accident. Among the available physical properties of the corium, the nature of the final crystalline compounds which have been made during the, cooling gives information about its solidification and its stabilisation. X-Rays Diffraction is the reference method used in order to characterize the corium coming from the different facilities of the European platform PLINIUS of CEA-Cadarache. This work presents the scientific approach that has been followed in order to obtain information both qualitative and quantitative on corium, using X-Rays Diffraction. For instance, a specific method for identifying U{sub 1-x}Zr{sub x}O{sub 2} solid solutions has been developed, and the validity of quantitative analysis of corium crystalline phases using the Rietveld method (with an internal standard), has been tested. This last method has also permitted semi-quantitative measurements of amorphous phases within corium. For these studies, analysis of prototypical corium has been conducted on samples coming from the experiences led on the different facilities of the PLINIUS platform. These analysis allowed for the first time to obtain quantitative data of the corium crystalline phases in order to validate thermodynamic databases and has been used to estimate the thereto-physical properties of the corium. New information on crystalline phases of corium has also been found, especially for the UO{sub 2}-ZrO{sub 2} pseudo binary system. (author)

  9. The CANDELLE experiment for characterization of neutron sensitivity of LiF TLDs

    Science.gov (United States)

    Guillou, M. Le; Billebaud, A.; Gruel, A.; Kessedjian, G.; Méplan, O.; Destouches, C.; Blaise, P.

    2018-01-01

    As part of the design studies conducted at CEA for future power and research nuclear reactors, the validation of neutron and photon calculation schemes related to nuclear heating prediction are strongly dependent on the implementation of nuclear heating measurements. Such measurements are usually performed in low-power reactors, whose core dimensions are accurately known and where irradiation conditions (power, flux and temperature) are entirely controlled. Due to the very low operating power of such reactors (of the order of 100 W), nuclear heating is assessed by using dosimetry techniques such as thermoluminescent dosimeters (TLDs). However, although they are highly sensitive to gamma radiation, such dosimeters are also, to a lesser extent, sensitive to neutrons. The neutron dose depends strongly on the TLD composition, typically contributing to 10-30% of the total measured dose in a mixed neutron/gamma field. The experimental determination of the neutron correction appears therefore to be crucial to a better interpretation of doses measured in reactor with reduced uncertainties. A promising approach based on the use of two types of LiF TLDs respectively enriched with lithium-6 and lithium-7, precalibrated both in photon and neutron fields, has been recently developed at INFN (Milan, Italy) for medical purposes. The CANDELLE experiment is dedicated to the implementation of a pure neutron field "calibration" of TLDs by using the GENEPI-2 neutron source of LPSC (Grenoble, France). Those irradiation conditions allowed providing an early assessment of the neutron components of doses measured in EOLE reactor at CEA Cadarache with 10% uncertainty at 1σ.

  10. Progress in the realization of the PRIMA neutral beam test facility

    Science.gov (United States)

    Toigo, V.; Boilson, D.; Bonicelli, T.; Piovan, R.; Hanada, M.; Chakraborty, A.; Agarici, G.; Antoni, V.; Baruah, U.; Bigi, M.; Chitarin, G.; Dal Bello, S.; Decamps, H.; Graceffa, J.; Kashiwagi, M.; Hemsworth, R.; Luchetta, A.; Marcuzzi, D.; Masiello, A.; Paolucci, F.; Pasqualotto, R.; Patel, H.; Pomaro, N.; Rotti, C.; Serianni, G.; Simon, M.; Singh, M.; Singh, N. P.; Svensson, L.; Tobari, H.; Watanabe, K.; Zaccaria, P.; Agostinetti, P.; Agostini, M.; Andreani, R.; Aprile, D.; Bandyopadhyay, M.; Barbisan, M.; Battistella, M.; Bettini, P.; Blatchford, P.; Boldrin, M.; Bonomo, F.; Bragulat, E.; Brombin, M.; Cavenago, M.; Chuilon, B.; Coniglio, A.; Croci, G.; Dalla Palma, M.; D'Arienzo, M.; Dave, R.; De Esch, H. P. L.; De Lorenzi, A.; De Muri, M.; Delogu, R.; Dhola, H.; Fantz, U.; Fellin, F.; Fellin, L.; Ferro, A.; Fiorentin, A.; Fonnesu, N.; Franzen, P.; Fröschle, M.; Gaio, E.; Gambetta, G.; Gomez, G.; Gnesotto, F.; Gorini, G.; Grando, L.; Gupta, V.; Gutierrez, D.; Hanke, S.; Hardie, C.; Heinemann, B.; Kojima, A.; Kraus, W.; Maeshima, T.; Maistrello, A.; Manduchi, G.; Marconato, N.; Mico, G.; Moreno, J. F.; Moresco, M.; Muraro, A.; Muvvala, V.; Nocentini, R.; Ocello, E.; Ochoa, S.; Parmar, D.; Patel, A.; Pavei, M.; Peruzzo, S.; Pilan, N.; Pilard, V.; Recchia, M.; Riedl, R.; Rizzolo, A.; Roopesh, G.; Rostagni, G.; Sandri, S.; Sartori, E.; Sonato, P.; Sottocornola, A.; Spagnolo, S.; Spolaore, M.; Taliercio, C.; Tardocchi, M.; Thakkar, A.; Umeda, N.; Valente, M.; Veltri, P.; Yadav, A.; Yamanaka, H.; Zamengo, A.; Zaniol, B.; Zanotto, L.; Zaupa, M.

    2015-08-01

    The ITER project requires additional heating by two neutral beam injectors, each accelerating to 1 MV a 40 A beam of negative deuterium ions, to deliver to the plasma a power of about 17 MW for one hour. As these requirements have never been experimentally met, it was recognized as necessary to setup a test facility, PRIMA (Padova Research on ITER Megavolt Accelerator), in Italy, including a full-size negative ion source, SPIDER, and a prototype of the whole ITER injector, MITICA, aiming to develop the heating injectors to be installed in ITER. This realization is made with the main contribution of the European Union, through the Joint Undertaking for ITER (F4E), the ITER Organization and Consorzio RFX which hosts the Test Facility. The Japanese and the Indian ITER Domestic Agencies (JADA and INDA) participate in the PRIMA enterprise; European laboratories, such as IPP-Garching, KIT-Karlsruhe, CCFE-Culham, CEA-Cadarache and others are also cooperating. Presently, the assembly of SPIDER is on-going and the MITICA design is being completed. The paper gives a general overview of the test facility and of the status of development of the MITICA and SPIDER main components at this important stage of the overall development; then it focuses on the latest and most critical issues, regarding both physics and technology, describing the identified solutions.

  11. 2010 ATSR prize; Prix ATSR 2010

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2011-07-01

    The article presents the testing of the new dosimetry system operating at the CEA Cadarache center. This system of passive and operational dosimetry is based on 3 dosimeters: PN3+, RPL and EPD-N2. PN3+ is a neutron track detector used for passive dosimetry that can detect fast and thermal neutrons, RPL is a photon passive dosimeter based on radio-photoluminescence, and EPD-N2 is an operational dosimeter detecting neutron and gamma radiations. The comparison of results from passive and operational neutron dosemeters have shown some inconsistencies: some neutron doses recorded by the operational dosimeter do not appear on the PN3+ dosimeter. This study shows that: the detecting threshold of the PN3+ dosimeter is higher than the value given by the manufacturer (100 {mu}Sv), the differences between the values given by PN3+ dosimeters in a series of trials involving either identical equivalent doses or similar neutron spectra and the real values fluctuate in an aleatory manner, and a second reading of some PN3+ dosimeters has shown that the reading stage may be the source of the discrepancies. This study has allowed the calibration of the RPL dosemeter. (A.C.)

  12. Didier Chanat (1959-2007)

    CERN Multimedia

    2007-01-01

    We deeply regret to announce the death of Mr Didier CHANAT on 05.09.2007. Mr Didier CHANAT, born on 27.05.1959, worked in the AT Department and had been employed at CERN since 01.06.1992. The Director-General has sent his family a message of condolence on behalf of the CERN staff. Social Affairs Tribute to Didier Chanat With a higher technical diploma and a specialisation in electrical engineering, Didier began his professional life at the CEA (France) in 1986. From then until 1990 he took part in developing control and supervision systems for the various Tore Supra tokamak systems at Cadarache, then in operating and upgrading the entire machine. From 1990 to 1992, Didier was a member of the Tore Supra Cryogenics Group, where he was responsible for operating and maintaining the cryogenic system. It was at this time that he developed an interest in cryogenics which was to remain the linchpin of the rest of his career...

  13. Corium spreading: hydrodynamics, rheology and solidification of a high-temperature oxide melt; L'etalement du corium: hydrodynamique, rheologie et solidification d'unbain d'oxydes a haute temperature

    Energy Technology Data Exchange (ETDEWEB)

    Journeau, Ch

    2006-06-15

    In the hypothesis of a nuclear reactor severe accident, the core could melt and form a high- temperature (2000-3000 K) mixture called corium. In the hypothesis of vessel rupture, this corium would spread in the reactor pit and adjacent rooms as occurred in Chernobyl or in a dedicated core-catcher s in the new European Pressurized reactor, EPR. This thesis is dedicated to the experimental study of corium spreading, especially with the prototypic corium material experiments performed in the VULCANO facility at CEA Cadarache. The first step in analyzing these tests consists in interpreting the material analyses, with the help of thermodynamic modelling of corium solidification. Knowing for each temperature the phase repartition and composition, physical properties can be estimated. Spreading termination is controlled by corium rheological properties in the solidification range, which leads to studying them in detail. The hydrodynamical, rheological and solidification aspects of corium spreading are taken into account in models and computer codes which have been validated against these tests and enable the assessment of the EPR spreading core-catcher concept. (author)

  14. Covariance generation and uncertainty propagation for thermal and fast neutron induced fission yields

    Science.gov (United States)

    Terranova, Nicholas; Serot, Olivier; Archier, Pascal; De Saint Jean, Cyrille; Sumini, Marco

    2017-09-01

    Fission product yields (FY) are fundamental nuclear data for several applications, including decay heat, shielding, dosimetry, burn-up calculations. To be safe and sustainable, modern and future nuclear systems require accurate knowledge on reactor parameters, with reduced margins of uncertainty. Present nuclear data libraries for FY do not provide consistent and complete uncertainty information which are limited, in many cases, to only variances. In the present work we propose a methodology to evaluate covariance matrices for thermal and fast neutron induced fission yields. The semi-empirical models adopted to evaluate the JEFF-3.1.1 FY library have been used in the Generalized Least Square Method available in CONRAD (COde for Nuclear Reaction Analysis and Data assimilation) to generate covariance matrices for several fissioning systems such as the thermal fission of U235, Pu239 and Pu241 and the fast fission of U238, Pu239 and Pu240. The impact of such covariances on nuclear applications has been estimated using deterministic and Monte Carlo uncertainty propagation techniques. We studied the effects on decay heat and reactivity loss uncertainty estimation for simplified test case geometries, such as PWR and SFR pin-cells. The impact on existing nuclear reactors, such as the Jules Horowitz Reactor under construction at CEA-Cadarache, has also been considered.

  15. A Covariance Generation Methodology for Fission Product Yields

    Directory of Open Access Journals (Sweden)

    Terranova N.

    2016-01-01

    Full Text Available Recent safety and economical concerns for modern nuclear reactor applications have fed an outstanding interest in basic nuclear data evaluation improvement and completion. It has been immediately clear that the accuracy of our predictive simulation models was strongly affected by our knowledge on input data. Therefore strong efforts have been made to improve nuclear data and to generate complete and reliable uncertainty information able to yield proper uncertainty propagation on integral reactor parameters. Since in modern nuclear data banks (such as JEFF-3.1.1 and ENDF/BVII.1 no correlations for fission yields are given, in the present work we propose a covariance generation methodology for fission product yields. The main goal is to reproduce the existing European library and to add covariance information to allow proper uncertainty propagation in depletion and decay heat calculations. To do so, we adopted the Generalized Least Square Method (GLSM implemented in CONRAD (COde for Nuclear Reaction Analysis and Data assimilation, developed at CEA-Cadarache. Theoretical values employed in the Bayesian parameter adjustment are delivered thanks to a convolution of different models, representing several quantities in fission yield calculations: the Brosa fission modes for pre-neutron mass distribution, a simplified Gaussian model for prompt neutron emission probability, theWahl systematics for charge distribution and the Madland-England model for the isomeric ratio. Some results will be presented for the thermal fission of U-235, Pu-239 and Pu-241.

  16. A Covariance Generation Methodology for Fission Product Yields

    Science.gov (United States)

    Terranova, N.; Serot, O.; Archier, P.; Vallet, V.; De Saint Jean, C.; Sumini, M.

    2016-03-01

    Recent safety and economical concerns for modern nuclear reactor applications have fed an outstanding interest in basic nuclear data evaluation improvement and completion. It has been immediately clear that the accuracy of our predictive simulation models was strongly affected by our knowledge on input data. Therefore strong efforts have been made to improve nuclear data and to generate complete and reliable uncertainty information able to yield proper uncertainty propagation on integral reactor parameters. Since in modern nuclear data banks (such as JEFF-3.1.1 and ENDF/BVII.1) no correlations for fission yields are given, in the present work we propose a covariance generation methodology for fission product yields. The main goal is to reproduce the existing European library and to add covariance information to allow proper uncertainty propagation in depletion and decay heat calculations. To do so, we adopted the Generalized Least Square Method (GLSM) implemented in CONRAD (COde for Nuclear Reaction Analysis and Data assimilation), developed at CEA-Cadarache. Theoretical values employed in the Bayesian parameter adjustment are delivered thanks to a convolution of different models, representing several quantities in fission yield calculations: the Brosa fission modes for pre-neutron mass distribution, a simplified Gaussian model for prompt neutron emission probability, theWahl systematics for charge distribution and the Madland-England model for the isomeric ratio. Some results will be presented for the thermal fission of U-235, Pu-239 and Pu-241.

  17. Progress of the ''batman'' RF source for negative hydrogen ions

    Energy Technology Data Exchange (ETDEWEB)

    Frank, P.; Heinemann, B.; Kraus, W.; Probst, F.; Speth, E.; Vollmer, O. [Max-Planck-Institut fuer Plasmaphysik, Garching (Germany); Bucalossi, J.; Trainham, R. [Association Euratom-CEA Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee

    1998-07-01

    The aim of a collaboration between CEA Cadarache and IPP Garching is to investigate the ability of an rf source to produce negative-ion current densities compatible with ITER NBI requirements (20 mA/cm{sup 2} D-). A standard PlNI-size rf source developed for ASDEX-Upgrade and a three-grid extraction system form the basis of BATMAN (Bavarian Test Machine for Negative Ions). In the case of a pure hydrogen plasma a current density of 5.5 mA/cm{sup 2} at elevated pressure (2.4 Pa) can be reached. Adding small amounts of argon (< 15 %) the current density increases up to a maximum of 8.5 mA/cm{sup 2}. In the low pressure range (0.7 Pa) the negative ion yield is strongly reduced, but with an admixture of argon and a cesium injection the current density is higher approx. by a factor 8 (4 mA/cm{sup 2}) compared to the pure hydrogen discharge. The negative ion yield shows a saturation with increasing rf power. (author)

  18. MASURCA facility - INB 39 - Complementary safety assessment in the light of the Fukushima Daiichi accident; Installation MASURCA - INB 39 - Evaluation complementaire de la surete au regard de l'accident survenu a la centrale nucleaire de Fukushima Daiichi

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-09-13

    This CSA (Complementary Safety Assessment) analyses the robustness of the Masurca facility to extreme situations such as those that led to the Fukushima accident and proposes a series of improvements. Masurca facility, that stands on the Cadarache CEA's site, has been stopped and is waiting upgrading works that will end in 2017. Robustness is the ability for the facility to withstand events beyond the level for which the facility was designed. Robustness is linked to safety margins but also to the situations leading to a sudden deterioration of the accident sequence (cliff edge effect). Safety is not only a matter of design or of engineered systems, it is also a matter of organization. So issues like crisis organization and work organization via subcontracting are also taken into consideration. This report is divided into 9 main chapters: 1) main features of the Masurca facility, 2) identification of cliff edge risks and of equipment essential for safety, 3) earthquake risk, 4) flood risk, 5) risks due to other extreme natural disasters, 6) the loss of electrical power supplies and of cooling systems, 7) management of severe accidents, 8) subcontracting policy, 9) synthesis. This study comforts the options chosen for the current upgrading, especially the construction of a new earthquake resistant building to house and store fissile materials and sodium. (A.C.)

  19. Americium-241 integral radiative capture cross section in over-moderated neutron spectrum from pile oscillator measurements in the Minerve reactor

    Science.gov (United States)

    Geslot, Benoit; Gruel, Adrien; Ros, Paul; Blaise, Patrick; Leconte, Pierre; Noguere, Gilles; Mathieu, Ludovic; Villamarin, David; Becares, Vicente; Plompen, Arjan; Kopecky, Stefan; Schillebeeckx, Peter

    2017-09-01

    An experimental program, called AMSTRAMGRAM, was recently conducted in the Minerve low power reactor operated by CEA Cadarache within the frame of the CHANDA initiative (Solving CHAllenges in Nuclear Data). Its aim was to measure the integral capture cross section of 241Am in the thermal domain. Motivation of this work is driven by large differences in this actinide thermal point reported by major nuclear data libraries. The AMSTRAMGRAM experiment, that made use of well characterized EC-JRC americium samples, was based on the oscillation technique commonly implemented in the Minerve reactor. First results are presented and discussed in this article. A preliminary calculation scheme was used to compare measured and calculated results. It is shown that this work confirms a bias previously observed with JEFF-3.1.1 (C/E-1 = -10.5 ± 2%). On the opposite, the experiment is in close agreement with 241Am thermal point reported in JEFF-3.2 (C/E-1 = 0.5 ± 2%).

  20. Americium-241 integral radiative capture cross section in over-moderated neutron spectrum from pile oscillator measurements in the Minerve reactor

    Directory of Open Access Journals (Sweden)

    Geslot Benoit

    2017-01-01

    Full Text Available An experimental program, called AMSTRAMGRAM, was recently conducted in the Minerve low power reactor operated by CEA Cadarache within the frame of the CHANDA initiative (Solving CHAllenges in Nuclear Data. Its aim was to measure the integral capture cross section of 241Am in the thermal domain. Motivation of this work is driven by large differences in this actinide thermal point reported by major nuclear data libraries. The AMSTRAMGRAM experiment, that made use of well characterized EC-JRC americium samples, was based on the oscillation technique commonly implemented in the Minerve reactor. First results are presented and discussed in this article. A preliminary calculation scheme was used to compare measured and calculated results. It is shown that this work confirms a bias previously observed with JEFF-3.1.1 (C/E-1 = −10.5 ± 2%. On the opposite, the experiment is in close agreement with 241Am thermal point reported in JEFF-3.2 (C/E-1 = 0.5 ± 2%.

  1. Qualification and characterization of electronics of the fast neutron Hodoscope detectors using neutrons from CABRI core

    Directory of Open Access Journals (Sweden)

    Mirotta S.

    2018-01-01

    Full Text Available The study of Reactivity Initiated Accidents (RIA is important to determine up to which limits nuclear fuels can withstand such accidents without clad failure. The CABRI International Program (CIP, conducted by IRSN under an OECD/NEA agreement, has been launched to perform representative RIA Integral Effect Tests (IET on real irradiated fuel rods in prototypical Pressurized Water Reactors (PWR conditions. For this purpose, the CABRI experimental pulse reactor, operated by CEA in Cadarache, France, has been strongly renovated, and equipped with a pressurized water loop. The behavior of the test rod, located in that loop in the center of the driver core, is followed in real time during the power transients thanks to the hodoscope, a unique online fuel motion monitoring system, and one of the major distinctive features of CABRI. The hodoscope measures the fast neutrons emitted by the tested rod during the power pulse with a complete set of 153 Fission Chambers and 153 Proton Recoil Counters. During the CABRI facility renovation, the electronic chain of these detectors has been upgraded. In this paper, the performance of the new system is presented describing gain calibration methodology in order to get maximal Signal/Noise ratio for amplification modules, threshold tuning methodology for the discrimination modules (old and new ones, and linear detectors response limit versus different reactor powers for the whole electronic chain.

  2. Sizing of photovoltaic system coupled with hydrogen/oxygen storage based on the ORIENTE model

    Energy Technology Data Exchange (ETDEWEB)

    Darras, C.; Sailler, S.; Thibault, C.; Muselli, M.; Poggi, P. [University of Corsica, UMR CNRS SPE 6134, Route des Sanguinaires, F-20000 Ajaccio (France); Hoguet, J.C.; Melscoet, S. [HELION Hydrogen Power, Domaine du Petit Arbois - Batiment Jules Verne, BP 71, 13545 Aix en Provence (France); Pinton, E.; Grehant, S. [Commissariat a l' Energie Atomique (CEA/LITEN), 17 rue des Martyrs, 38 054 Grenoble Cedex 9 (France); Gailly, F.; Turpin, C.; Astier, S.; Fontes, G. [Universite de Toulouse, INP, UPS, LAPLACE (Laboratoire Plasma et Conversion d' Energie), ENSEEIHT, 2 rue Charles Camichel, BP 7122, F-31071 Toulouse Cedex 7 (France); CNRS, LAPLACE, F-31071 Toulouse (France)

    2010-04-15

    PEPITE is a project funded by the French ANR PAN-H research program. This project concerns, among various other tasks, a demonstration of a weather station electricity supply with help of a PV/FC/EL hybrid system located at the CEA center of Cadarache (France). To design a relevant sizing for this demonstration system, a complete sizing tool has been developed via a new numerical optimizing code named ORIENTE. It uses Matlab software based on sequential running time. The demonstration system will be composed of a PV array, a PEM fuel cell system and a PEM electrolyzer, batteries, storage tanks for H{sub 2}, O{sub 2} and H{sub 2}O, as well as associated converters. This paper presents the obtained optimal sizing curves for the hybrid system (P{sub pv} [kWp], Q{sub H{sub 2}}{sub max} [kg]) by taking into account the predefined constant load (6.5 kW) functioning 24/24 hours and the system energy balance for a loss-of-load probability LLP = 0. These results give the sizes of each subsystem and will make possible to build the best energy flows control mode. (author)

  3. First feedback with the AMMON integral experiment for the JHR calculations

    Directory of Open Access Journals (Sweden)

    Lemaire M.

    2013-03-01

    Full Text Available The innovative design of the next international Material Testing Reactor, the Jules Horowitz Reactor (JHR, induced the development of a new neutron and photon calculation formular HORUS3D/P&N, based on deterministic and stochastic codes and the European nuclear data library JEFF3.1.1. A new integral experiment, named the AMMON experiment, was designed in order to make the experimental validation of HORUS3D. The objectives of this experimental program are to calibrate the biases and uncertainties associated with the HORUS3D/N&P calculations for JHR safety and design calculations, but also the validation of some specific nuclear data (concerning mainly hafnium and beryllium isotopes. The experiment began in 2010 and is currently performed in the EOLE zero-power critical mock-up at CEA Cadarache. This paper deals with the first feedback of the AMMON experiments with 3D Monte Carlo TRIPOLI4©/JEFF3.1.1 calculations.

  4. Innovative hybrid pile oscillator technique in the Minerve reactor: open loop vs. closed loop

    Directory of Open Access Journals (Sweden)

    Geslot Benoit

    2018-01-01

    Full Text Available Pile oscillator techniques are powerful methods to measure small reactivity worth of isotopes of interest for nuclear data improvement. This kind of experiments has long been implemented in the Mineve experimental reactor, operated by CEA Cadarache. A hybrid technique, mixing reactivity worth estimation and measurement of small changes around test samples is presented here. It was made possible after the development of high sensitivity miniature fission chambers introduced next to the irradiation channel. A test campaign, called MAESTRO-SL, took place in 2015. Its objective was to assess the feasibility of the hybrid method and investigate the possibility to separate mixed neutron effects, such as fission/capture or scattering/capture. Experimental results are presented and discussed in this paper, which focus on comparing two measurements setups, one using a power control system (closed loop and another one where the power is free to drift (open loop. First, it is demonstrated that open loop is equivalent to closed loop. Uncertainty management and methods reproducibility are discussed. Second, results show that measuring the flux depression around oscillated samples provides valuable information regarding partial neutron cross sections. The technique is found to be very sensitive to the capture cross section at the expense of scattering, making it very useful to measure small capture effects of highly scattering samples.

  5. LECA refurbishment project or how to get ready for the next ten years

    Energy Technology Data Exchange (ETDEWEB)

    Boussard, Francois; Bois, Dominique; Blanc, Jean Yves

    2005-01-01

    Around 1995, CEA decided a strategy for its hot laboratories: Closing LAMA - Grenoble and LHA - Saclay, after RM2 - Fontenay-aux-Roses. Refurbishing and gathering irradiated material studies in LECI - Saclay. Refurbishing LECA - Cadarache for irradiated fuel examinations. Reprocessing pilot experiments being located in Atalante - Marcoule. Started up in 1964, LECA has got an exploitation license up to August 2005. In 2001, safety authorities agreed to extend it up to 2015, provided an extensive refurbishment is undertaken which includes civil engineering works to achieve the building earthquake resistance, based on 3D-computations and withstanding maximum historically likely earthquake, improving confinement by decontaminating, adding steel boxes inside cells, changing ventilation system and creating a mobile upper cell on the cell roof, changing power supplies, shielded glasses and most manipulators, improving travelling crane, fire protection, radioactivity monitoring and alarms, installing a new device for characterizing and evacuating wastes, decreasing the fissile mass stored inside the facility (source term). Most of the work should be ended by the end of 2005. Afterwards five cells, which do not withstand earthquake, will be deconstructed within 3 years. By mid 2004, 60 % of tasks are completed and all contracts are awarded. The total final cost is 97 M Euro, 80% of which regarding the only LECA refurbishment. (Author)

  6. Calculations to Support On-line Neutron Spectrum Adjustment by Measurements with Miniature Fission Chambers in the JSI TRIGA Reactor

    Directory of Open Access Journals (Sweden)

    Kaiba Tanja

    2018-01-01

    Full Text Available Preliminary calculations were performed with the aim to establish optimal experimental conditions for the measurement campaign within the collaboration between the Jožef Stefan Institute (JSI and Commissariat à l’Énergie Atomique et aux Énergies Alternatives (CEA Cadarache. The goal of the project is to additionally characterize the neutron spectruminside the JSI TRIGA reactor core with focus on the measurement epi-thermal and fast part of the spectrum. Measurements will be performed with fission chambers containing different fissile materials (235U, 237Np and 242Pu covered with thermal neutron filters (Cd and Gd. The changes in the detected signal and neutron flux spectrum with and without transmission filter were studied. Additional effort was put into evaluation of the effect of the filter geometry (e.g. opening on the top end of the filter on the detector signal. After the analysis of the scoping calculations it was concluded to position the experiment in the outside core ring inside one of the empty fuel element positions.

  7. Analysis of High-Moderation MOX Core MISTRAL-3 with SRAC and MVP

    Energy Technology Data Exchange (ETDEWEB)

    Ishii, K.; Tatsumi, M.; Hibi, K.; Sakurada, K.; Yamamoto, T.; Iwata, Y.; Ueji, M.

    2001-06-17

    To obtain reactor physics parameters for high-moderation mixed-oxide (MOX) cores, Nuclear Power Engineering Corporation (NPEC), the French Atomic Commission (CEA), and their industrial partners have conducted a MOX core physics experimental program called MISTRAL with the EOLE critical facility of the Cadarache research center. This program consists of four high-moderation cores and was successfully completed in July 2000. This paper describes the analysis results of MISTRAL-3 that is a homogeneous full MOX cylindrical core (H/HM = 6.2) with an 80-cm height and a 59-cm diameter consisting of 1388 standard pressurized water reactor-type MOX fuel rods of 7.0 wt% plutonium-enrichment in a square pitch of 1.39 cm. NPEC has been analyzing the experimental results by using the SRAC and MVP code systems. SRAC and MVP calculate the nuclear core characteristics correctly for the high-moderation MOX core MISTRAL-3. No apparent trend with the moderation ratio is observed in these calculation results.

  8. Validation of Helium Inlet Design for ITER Toroidal Field Coil

    CERN Document Server

    Boyer, C; Hamada, K; Foussat, A; Le Rest, M; Mitchell, N; Decool, P; Savary, F; Sgobba, S; Weiss, K-P

    2014-01-01

    The ITER organization has performed design and its validation tests on a helium inlet structure for the ITER Toroidal Field (TF) coil under collaboration with CERN, KIT, and CEA-Cadarache. Detailed structural analysis was performed in order to optimize the weld shape. A fatigue resistant design on the fillet weld between the shell covers and the jacket is an important point on the helium inlet structure. A weld filler material was selected based on tensile test at liquid helium temperature after Nb3Sn reaction heat treatment. To validate the design of the weld joint, fatigue tests at 7 K were performed using heat-treated butt weld samples. A pressure drop measurement of a helium inlet mock-up was performed by using nitrogen gas at room temperature in order to confirm uniform flow distribution and pressure drop characteristic. These tests have validated the helium inlet design. Based on the validation, Japanese and European Union domestic agencies, which have responsibilities of the TF coil procurement, are pr...

  9. The CABRI fast neutron Hodoscope: Renovation, qualification program and first results following the experimental reactor restart

    Science.gov (United States)

    Chevalier, V.; Mirotta, S.; Guillot, J.; Biard, B.

    2018-01-01

    The CABRI experimental pulse reactor, located at the Cadarache nuclear research center, southern France, is devoted to the study of Reactivity Initiated Accidents (RIA). For the purpose of the CABRI International Program (CIP), managed and funded by IRSN, in the framework of an OECD/NEA agreement, a huge renovation of the facility has been conducted since 2003. The Cabri Water Loop was then installed to ensure prototypical Pressurized Water Reactor (PWR) conditions for testing irradiated fuel rods. The hodoscope installed in the CABRI reactor is a unique online fuel motion monitoring system, operated by IRSN and dedicated to the measurement of the fast neutrons emitted by the tested rod during the power pulse. It is one of the distinctive features of the CABRI reactor facility, which is operated by CEA. The system is able to determine the fuel motion, if any, with a time resolution of 1 ms and a spatial resolution of 3 mm. The hodoscope equipment has been upgraded as well during the CABRI facility renovation. This paper presents the main outcomes achieved with the hodoscope since October 2015, date of the first criticality of the CABRI reactor in its new Cabri Water Loop configuration. Results obtained during reactor commissioning phase functioning, either in steady-state mode (at low and high power, up to 23 MW) or in transient mode (start-up, possibly beyond 20 GW), are discussed.

  10. Study of the linearity of CABRI experimental ionization chambers during RIA transients

    Science.gov (United States)

    Lecerf, J.; Garnier, Y.; Hudelot, JP.; Duc, B.; Pantera, L.

    2018-01-01

    CABRI is an experimental pulse reactor operated by CEA at the Cadarache research center and funded by the French Nuclear Safety and Radioprotection Institute (IRSN). For the purpose of the CABRI International Program (CIP), operated and managed by IRSN under an OECD/NEA framework it has been refurbished since 2003 to be able to provide experiments in prototypical PWR conditions (155 bar, 300 °C) in order to study the fuel behavior under Reactivity Initiated Accident (RIA) conditions. This paper first reminds the objectives of the power commissioning tests performed on the CABRI facility. The design and location of the neutron detectors monitoring the core power are also presented. Then it focuses on the different methodologies used to calibrate the detectors and check the consistency and co-linearity of the measurements. Finally, it presents the methods used to check the linearity of the neutron detectors up to the high power levels ( 20 GW) reached during power transients. Some results obtained during the power tests campaign are also presented.

  11. Qualification and characterization of electronics of the fast neutron Hodoscope detectors using neutrons from CABRI core

    Science.gov (United States)

    Mirotta, S.; Guillot, J.; Chevalier, V.; Biard, B.

    2018-01-01

    The study of Reactivity Initiated Accidents (RIA) is important to determine up to which limits nuclear fuels can withstand such accidents without clad failure. The CABRI International Program (CIP), conducted by IRSN under an OECD/NEA agreement, has been launched to perform representative RIA Integral Effect Tests (IET) on real irradiated fuel rods in prototypical Pressurized Water Reactors (PWR) conditions. For this purpose, the CABRI experimental pulse reactor, operated by CEA in Cadarache, France, has been strongly renovated, and equipped with a pressurized water loop. The behavior of the test rod, located in that loop in the center of the driver core, is followed in real time during the power transients thanks to the hodoscope, a unique online fuel motion monitoring system, and one of the major distinctive features of CABRI. The hodoscope measures the fast neutrons emitted by the tested rod during the power pulse with a complete set of 153 Fission Chambers and 153 Proton Recoil Counters. During the CABRI facility renovation, the electronic chain of these detectors has been upgraded. In this paper, the performance of the new system is presented describing gain calibration methodology in order to get maximal Signal/Noise ratio for amplification modules, threshold tuning methodology for the discrimination modules (old and new ones), and linear detectors response limit versus different reactor powers for the whole electronic chain.

  12. LIBS for tokamak plasma facing components characterisation: Perspectives on in situ tritium cartography

    Energy Technology Data Exchange (ETDEWEB)

    Semerok, A., E-mail: alexandre.semerok@cea.fr [CEA, DEN, DPC/SEARS/LISL, F-91191 Gif-sur-Yvette (France); Grisolia, C. [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France)

    2013-08-21

    Feasibility of in situ LIBS remote measurements with the plasma facing components (PFCs) from the European tokamaks (TORE SUPRA, CEA Cadarache, France and TEXTOR, Julich, Germany) has been studied in laboratory using Q-switched nanosecond Nd–YAG lasers. LIBS particular properties and optimal parameters were determined for in-depth PFCs characterisation. The LIBS method was in situ tested on the Joint European Torus (JET) in the UK with the EDGE LIDAR Laser System (Ruby laser, 3 J, 690 nm wavelength, 300 ps pulse duration, intensity up to 70 GW/cm{sup 2}). Several analytical spectral lines of H, CII, CrI, and BeII in plasma were observed and identified in 400–600 nm spectral range with the optimised LIBS and detection system. The LIBS in-depth cartography is in agreement with the surface properties of the tile under analysis, thus confirming feasibility of in situ LIBS. Further LIBS technique improvements required to provide tritium concentration measurements more accurately are discussed.

  13. Neutron Commissioning in the New CABRI Water Loop Facility

    Science.gov (United States)

    Ritter, G.; Gueton, O.; Mellier, F.; Beretz, D.

    2010-10-01

    The CABRI experimental reactor is located at the Cadarache nuclear research center, southern France. It is operated by the Atomic Energy Commission (CEA) and devoted to Institut de Radioprotection et de Sûreté Nucléaire (IRSN) safety programs. It has been successfully operated during the last 30 years, enlightening the knowledge of FBR and LWR fuel behavior during Reactivity Insertion Accident (RIA) and Loss Of Coolant Accident (LOCA) transients in the frame of Institut de Protection et de Sûreté Nucléaire (IPSN) and now IRSN programs devoted to reactor safety. This operation was interrupted in 2003 to allow for a whole facility renewal program. The main goal of this reconstruction project is to meet thermal hydraulics parameters identical to LWR standard and downgraded conditions, in particular for the need of the CABRI International Programme (CIP) carried out by IRSN under the OECD umbrella. For this, the sodium cooled experimental loop is now being replaced by a pressurized water loop. The distinctive features of CABRI core allow for a specific neutron commissioning program. This paper presents the parameters to be measured with associated experimental methods and also briefly introduces the instrumentation set up.

  14. The stainless steel bulk shielding benchmark experiment at the Frascati Neutron Generator (FNG)

    Energy Technology Data Exchange (ETDEWEB)

    Batistoni, P. (Associazione Euratom-ENEA sulla Fusione, CRE Frascati, I-00044 Frascati, Rome (Italy)); Angelone, M. (Associazione Euratom-ENEA sulla Fusione, CRE Frascati, I-00044 Frascati, Rome (Italy)); Martone, M. (Associazione Euratom-ENEA sulla Fusione, CRE Frascati, I-00044 Frascati, Rome (Italy)); Petrizzi, L. (Associazione Euratom-ENEA sulla Fusione, CRE Frascati, I-00044 Frascati, Rome (Italy)); Pillon, M. (Associazione Euratom-ENEA sulla Fusione, CRE Frascati, I-00044 Frascati, Rome (Italy)); Rado, V. (Associazione Euratom-ENEA sulla Fusione, CRE Frascati, I-00044 Frascati, Rome (Italy)); Santamarina, A. (Commissariat a l' Energie Atomique, Centre d' Etudes Nucleaires Cadarache, 13108, St.-Paul-lez-Durance Cedex (France)); Abidi, I. (Commissariat a l' Energie Atomique, Centre d' Etudes Nucleaires Cadarache, 13108, St.-Paul-lez-Durance Cedex (France)); Gastaldi, G. (Commissariat a l' Energie Atomique, Centre d' Etudes Nucleaires Cadarache, 13108, St.-Paul-lez-Durance Cedex

    1994-09-01

    In the framework of the European Technology Program for NET/ITER, ENEA (Ente Nazionale per le Nuove Tecnologie, l'Energia e l'Ambiente), Frascati and CEA (Commissariat a l'Energie Atomique), Cadarache, are collaborating on a bulk shielding benchmark experiment using the 14 MeV Frascati Neutron Generator (FNG). The aim of the experiment is to obtain accurate experimental data for improving the nuclear database and methods used in the shielding designs, through a rigorous analysis of the results. The experiment consists of the irradiation of a stainless steel block by 14 MeV neutrons. The neutron flux and spectra at different depths, up to 65 cm inside the block, are measured by fission chambers and activation foils characterized by different energy response ranges. The [gamma]-ray dose measurements are performed with ionization chambers and thermo-luminescent dosimeters (TLD). The first results are presented, as well as the comparison with calculations using the cross section library EFF (European Fusion File). ((orig.))

  15. Benchmark experiment on stainless steel bulk shielding at Frascati neutron generator

    Energy Technology Data Exchange (ETDEWEB)

    Batistoni, P.; Angelone, M.; Martone, M.; Pillon, M.; Rado, V. [ENEA, Frascati (Italy). Centro Ricerche Energia - Area Energia e Innovazione

    1994-11-01

    In the framework of the European Technology Program for NET/ITER, ENEA (Italian Agency for New Technologies, Energy and Environment) - Frascati and CEA (Commissariat a L`Energie Atomique) - Cadarache collaborated on a Bulk Shield Benchmark Experiment using the 14-MeV Frascati Neutron Generator (FNG). The aim of the experiment was to obtain accurate experimental data for improving the nuclear database and methods used in shielding designs, through a rigorous analysis of the results. The experiment consisted of the irradiation of a stainless steel block by 14-MeV neutrons. The neutron reaction rates at different depths inside the block were measured by fission chambers and activation foils characterized by different energy response ranges. The experimental results have been compared with numerical results calculated using both S{sub N} and Monte Carlo transport codes and as transport cross section library the European Fusion File (EFF). In particular, the present report describes the experimental and numerical activity, including neutron measurements and Monte Carlo calculations, carried out by the (ENEA Italian Agency for New Technologies, Energy and Environment) team.

  16. The stainless steel bulk shielding benchmark experiment at the Frascati Neutron Generator (FNG)

    Science.gov (United States)

    Batistoni, P.; Angelone, M.; Martone, M.; Petrizzi, L.; Pillon, M.; Rado, V.; Santamarina, A.; Abidi, I.; Gastaldi, G.; Joyer, P.; Marquette, J. P.; Martini, M.

    1994-09-01

    In the framework of the European Technology Program for NET/ITER, ENEA (Ente Nazionale per le Nuove Tecnologie, l'Energia e l'Ambiente), Frascati and CEA (Commissariat à l'Energie Atomique), Cadarache, are collaborating on a bulk shielding benchmark experiment using the 14 MeV Frascati Neutron Generator (FNG). The aim of the experiment is to obtain accurate experimental data for improving the nuclear database and methods used in the shielding designs, through a rigorous analysis of the results. The experiment consists of the irradiation of a stainless steel block by 14 MeV neutrons. The neutron flux and spectra at different depths, up to 65 cm inside the block, are measured by fission chambers and activation foils characterized by different energy response ranges. The γ-ray dose measurements are performed with ionization chambers and thermo-luminescent dosimeters (TLD). The first results are presented, as well as the comparison with calculations using the cross section library EFF (European Fusion File).

  17. CONRAD Evaluation Code: Development Status and Perspectives

    Science.gov (United States)

    Archier, P.; De Saint Jean, C.; Litaize, O.; Noguère, G.; Berge, L.; Privas, E.; Tamagno, P.

    2014-04-01

    CONRAD is an object-oriented code developed at CEA Cadarache since 2005 to treat issues occurring during the data assimilation process. The last new features of the code in terms of experimental, theoretical and interface aspects are presented in this paper. The experimental descriptions capabilities have been enhanced thanks to the implementation of both analytical (Chi-Square, Gaussian) and Monte-Carlo resolution functions which are required for neutron resonance shape analysis. On the theoretical aspects, efforts have been focused on the fast energy region with the wrapping of the ECIS and TALYS codes and the management of optical model and statistical parameters. These new features make it possible for CONRAD to currently perform evaluations from 0 to 20 MeV. Concerning the interfacing developments, a multigroup cross-sections generating tool and an ENDF parser have been recently improved to produce multigroup cross-section covariance matrices in the frame of the JEFF project. Several examples and comparisons with other codes (SAMMY, REFIT) are provided to validate each development.

  18. Innovative hybrid pile oscillator technique in the Minerve reactor: open loop vs. closed loop

    Science.gov (United States)

    Geslot, Benoit; Gruel, Adrien; Bréaud, Stéphane; Leconte, Pierre; Blaise, Patrick

    2018-01-01

    Pile oscillator techniques are powerful methods to measure small reactivity worth of isotopes of interest for nuclear data improvement. This kind of experiments has long been implemented in the Mineve experimental reactor, operated by CEA Cadarache. A hybrid technique, mixing reactivity worth estimation and measurement of small changes around test samples is presented here. It was made possible after the development of high sensitivity miniature fission chambers introduced next to the irradiation channel. A test campaign, called MAESTRO-SL, took place in 2015. Its objective was to assess the feasibility of the hybrid method and investigate the possibility to separate mixed neutron effects, such as fission/capture or scattering/capture. Experimental results are presented and discussed in this paper, which focus on comparing two measurements setups, one using a power control system (closed loop) and another one where the power is free to drift (open loop). First, it is demonstrated that open loop is equivalent to closed loop. Uncertainty management and methods reproducibility are discussed. Second, results show that measuring the flux depression around oscillated samples provides valuable information regarding partial neutron cross sections. The technique is found to be very sensitive to the capture cross section at the expense of scattering, making it very useful to measure small capture effects of highly scattering samples.

  19. Progress report 2000 / 2001; Rapport d'activite 2000 / 2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The 2000-2001 period has seen many facts of importance for the EURATOM-Cea association. The first outstanding fact is the positive evolution of the ITER project because of both the willingness of the partners and the French proposition to the European Union to consider the Cadarache site as the European site. The second outstanding fact is both the installation on Tore-Supra of a new generation of plasma-facing component: the Ciel project and the launch of the Cimes project whose aim is to allow Tore-Supra to reach discharge up to 1000 s. The third outstanding fact is the continuation of experiments in Jet after 1999, end date of the Jet Joint Undertaking. These new provisions aim at maintaining in activity the spearhead of the European program, waiting for a clarification of the ITER situation. Among the results obtained in Jet operations, we can quote those having a direct influence on the ITER performances: - the beneficial effect of a high triangularity on the ELM (edge localized modes) and on the confinement factor at high density, - the real time control of advanced tokamak discharges at quasi steady state, and the theoretical explanation of the current hole (in lower hybrid advanced scenarios, a region with vanishing current density that appears in the plasma centre). (A.C.)

  20. The GUINEVERE project at the VENUS-F Facility

    Energy Technology Data Exchange (ETDEWEB)

    Baeten, P.; Ait Abderrahim, H.; Bergmans, G.; Kochetkov, A.; Uyttenhove, W.; Vandeplassche, D.; Vermeersch, F.; Vittiglio, G. [SCK-CEN, Boeretang 200, B-2400 Mol (Belgium); Ban, G.; Baylac, M.; Billebaud, A.; Bondoux, D.; Bouvier, J.; Chabod, S.; De Conto, J.M.; Dessagne, P.; Gaudiot, G.; Gautier, J.M.; Heitz, G.; Kerveno, M.; Laune, B.; Lecolley, F.R.; Lecouey, J.L.; Marie, N.; Merrer, Y.; Nuttin, A.; Reynet, D.; Steckmeyer, J.C. [CNRS-IN2P3 (France); Mellier, F. [CEA/DEN/SPeX/LPE, CEN Cadarache, F-13104 Saint-Paul-lez-Durance (France)

    2010-07-01

    Within the framework of the ECATS (Experimental activities on the Coupling of an Accelerator, a spallation Target and a Sub-critical blanket) research domain of the FP6 IP-EUROTRANS program, the GUINEVERE (Generation of Uninterrupted Intense Neutron pulses at the lead Venus Reactor) project was launched in 2006 in order to check in the experiments an open questions stay for the techniques used in the MUSE programme (CEA Cadarache, France, 2000-2004), related to the online reactivity monitoring, sub-criticality determination and operational procedure of an Accelerator Driven System. For this purpose, the VENUS light water critical reactor at the SCK-CEN site of Mol (Belgium) was modify into a subcritical fast core (VENUS-F) and the GENEPI accelerator, designed for the MUSE experiment was up-graded to the new GENEPI-3C accelerator. The VENUS-F coupled with the GENEPI-3C and a TiT target will provide a unique facility in Europe for fast sub-critical and critical reactor physics investigations. This paper describes the present status of the facility. (authors)

  1. [Present conceptions of the C.E.A. concerning] the development of fast neutron reactors in France; [Les conceptions actuelles du C.E.A. concernant] la filiere des reacteurs a neutrons rapides en France

    Energy Technology Data Exchange (ETDEWEB)

    Vendryes, G.; Gaussens, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Pasquer, R. [Electricite de France (EDF), 75 - Paris (France)

    1964-07-01

    1 - The position of fast neutron reactors in the French nuclear energy program. In developing a program based on natural uranium, France will have an important stock of plutonium rich in higher isotopes. The existence of this plutonium and of the depleted uranium arising from the same reactors, has, as a logical consequence, the use of both in fast neutron reactors. Justified by this short term interest, the achievement of fast neutron reactors does, moreover, provide for a future necessity. 2 - Description of a fast neutron central power station of 1000 MWe. We indicate the characteristics of a future fast neutron central power station, plutonium fuelled, and sodium cooled. However uncertain these characteristics may be, they constitute a necessary guide in the orientation of our work. 3 - Studies carried out up to the present time. We give an outline of those studies, often very preliminary, which have given the characteristics cited above. The principal technical areas taken up are the following: - Neutronics (critical masses, breeding ratios, enrichments, flattening of the neutron flux, coefficients of reactivity, reactivity changes as a function of irradiation). - Dynamics, control, and safety. - Technology (design of the core and vessel, of the sodium system, and of the fuel handling mechanisms). These technical studies are complemented by economic considerations. The choice of the optimum characteristics is related to the existence of power production programs, and, in these programs, to the existence of plutonium producing thermal reactors. It is shown how, in this context, the existence of plutonium should be taken into account, and, in addition which mechanisms relate the economics of this plutonium to the choice of the most important parameters of the breeder reactors. 4 - Prototype reactor. The interest in an intermediate stage consisting of a reactor of a power level of about 80 MWe is justified. Its essential characteristics are briefly presented. (authors) [French] 1 - Situation des reacteurs a neutrons rapides dans le programme d'energie nucleaire francais. En developpant un programme base sur l'uranium naturel, la France se trouvera dotee d'un stock important de plutonium riche on isotopes superieurs. L'existence de ce plutonium et de l'uranium appauvri provenant des memes reacteurs a pour consequence logique leur emploi dans des reacteurs a neutrons rapides. Justifiee par cet interet a court terme, la mise au point de reacteurs a neutrons rapides repond par ailleurs a une necessite pour l'avenir. 2 - Enonce des caracteristiques d'une centrale a neutrons rapides de 1000 MW el. Nous indiquons les caracteristiques d'une future centrale a neutrons rapides chargee au plutonium et refroidie au sodium. Si incertaines qu'elles soient, elles constituent un guide necessaire a l'orientation de nos travaux. 3 - Etudes effectuees a ce jour: Nous donnons un apercu des etudes souvent tres preliminaires qui ont permis de retenir les caracteristiques citees plus haut. Les principaux domaines techniques abordes sont les suivants: - Neutronique (masses critiques, taux de regeneration, enrichissements, aplatissement du flux de neutrons, coefficients de reactivite, evolution de la reactivite en fonction de l'irradiation), - Dynamique, controle et surete, - Combustible, - Technologie (conception du bloc-pile, des circuits de sodium, des dispositifs pour la manutention des assemblages). Ces etudes techniques se completent de considerations economiques. Le choix de caracteristiques optimales est lie a l'existence de programmes de production d'electricite et, dans ces programmes, a celle des reacteurs a neutrons thermiques producteurs de plutonium. On montre comment il y a lieu de tenir compte de l'existence du plutonium dans ce contexte, et quels sont les mecanismes qui rattachent l'economie de ce plutonium au choix des parametres essentiels des reacteurs surgenerateurs. 4 - Reacteur prototype: On justifie l'interet d'une etape intermediaire constituee par un reacteur d'une puissance voisine de 80 MWel. Ses caracteristiques essentielles sont brievement presentees. (auteurs)

  2. Implicación de los alcaloides de las solanáceas comestibles en la etiopatogenia del prurito cicatricial

    OpenAIRE

    Alonso García, Pedro Enrique

    2016-01-01

    El prurito (picor) cicatricial se da con frecuencia en la práctica clínica y de modo particular en el paciente quemado. Cuando su intensidad es importante puede llegar a producir disminución de la capacidad de concentración, alteraciones del sueño y lesiones por rascado, todo lo cual puede perjudicar la recuperación de estos pacientes (1). De hecho en estudios recientes se ha demostrado que el prurito constituye uno de los factores determinantes principales de cara a la rehabilitación multifu...

  3. Development of an OF-CEAS laser spectrometer for water vapor isotope measurements at low water concentrations

    NARCIS (Netherlands)

    Landsberg, Janek

    2014-01-01

    The determination of the isotopic composition of water vapor is an important tool in atmospheric research. The isotopic composition of water in Antarctic or Arctic glacial ice can be used as a paleo-thermometer in the reconstruction of climate changes in the past. The isotope ratios of water vapor

  4. Repetitively Mode-Locked Cavity-Enhanced Absorption Spectroscopy (RML-CEAS) for Near-Infrared Gas Sensing.

    Science.gov (United States)

    He, Qixin; Lou, Minhan; Zheng, Chuantao; Ye, Weilin; Wang, Yiding; Tittel, Frank K

    2017-12-02

    A Pound-Drever-Hall (PDH)-based mode-locked cavity-enhanced sensor system was developed using a distributed feedback diode laser centered at 1.53 µm as the laser source. Laser temperature scanning, bias control of the piezoelectric ceramic transducer (PZT) and proportional-integral-derivative (PID) feedback control of diode laser current were used to repetitively lock the laser modes to the cavity modes. A gas absorption spectrum was obtained by using a series of absorption data from the discrete mode-locked points. The 15 cm-long Fabry-Perot cavity was sealed using an enclosure with an inlet and outlet for gas pumping and a PZT for cavity length tuning. The performance of the sensor system was evaluated by conducting water vapor measurements. A linear relationship was observed between the measured absorption signal amplitude and the H₂O concentration. A minimum detectable absorption coefficient of 1.5 × 10-8 cm-1 was achieved with an averaging time of 700 s. This technique can also be used for the detection of other trace gas species by targeting the corresponding gas absorption line.

  5. Repetitively Mode-Locked Cavity-Enhanced Absorption Spectroscopy (RML-CEAS for Near-Infrared Gas Sensing

    Directory of Open Access Journals (Sweden)

    Qixin He

    2017-12-01

    Full Text Available A Pound-Drever-Hall (PDH-based mode-locked cavity-enhanced sensor system was developed using a distributed feedback diode laser centered at 1.53 µm as the laser source. Laser temperature scanning, bias control of the piezoelectric ceramic transducer (PZT and proportional-integral-derivative (PID feedback control of diode laser current were used to repetitively lock the laser modes to the cavity modes. A gas absorption spectrum was obtained by using a series of absorption data from the discrete mode-locked points. The 15 cm-long Fabry-Perot cavity was sealed using an enclosure with an inlet and outlet for gas pumping and a PZT for cavity length tuning. The performance of the sensor system was evaluated by conducting water vapor measurements. A linear relationship was observed between the measured absorption signal amplitude and the H2O concentration. A minimum detectable absorption coefficient of 1.5 × 10–8 cm–1 was achieved with an averaging time of 700 s. This technique can also be used for the detection of other trace gas species by targeting the corresponding gas absorption line.

  6. Institut de recherche sur la fusion par confinement magnetique. Association EURATOM-CEA. Annual report 2008 (Full Report)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    The 2008 experimental campaign on Tore-Supra has been especially fruitful with the completion of multi-annual programmes bringing important answers, notably on operational aspects of long duration discharges. Concerning JET, particular effort have been devoted to: -) hydrogen isotopes retention studies, -) advanced scenarios studies such as JT60-JET physics identity experiments in ITB regimes, -) the commissioning of the ITER-like ICRH antenna, and -) high power level commissioning of the LHCD antenna and long distance coupling studies. Concerning integrated modelling, the development of the CRONOS code suite has been carried on, with particular emphasis on increasing its reliability and international coverage. CRONOS has been extensively used to investigate steady-state scenarios for ITER and DEMO. Most of the technological developments carried out by the Association concentrates on key domains that apply to ITER: superconducting conductors, actively cooled PFC (plasma facing components), or diagnostics. This document is divided into 5 main section: 1) Tore-Supra status, 2) theory and modeling, 3) Experimental physics, 4) technological developments, and 5) participation to W7X construction

  7. CACTÁCEAS NATIVAS ASSOCIADAS A FENOS DE FLOR DE SEDA E SABIÁ NA ALIMENTAÇÃO DE BORREGOS

    Directory of Open Access Journals (Sweden)

    JOSÉ GERALDO MEDEIROS DA SILVA

    2010-01-01

    Full Text Available The objective of this study was to evaluate the utilization effects of two native cacti named mandacaru (Cereus jamacaru DC. and xiquexique [Pilosocereus gounellei (A. Weber ex K. Schum. Bly ex Rowl.] associated with sabiá (Mimosa caesalpiniifolia Benth. and flor de seda (Calotropis procera (Ait. R.Br. about the nutrient intake, daily weight gain, and feed conversion in sheep feedlot. Twenty Morada Nova male hair sheep with an average weight of 15.40, were allocated in a randomized block design, with four treatments and five replicates. The experimental treatments consisted of four diets (30% native cacti + 30% shrub hay + 40% concentrate, on dry matter basis: T1- xiquexique + sabiá hay; T2- xiquexique + flor de seda hay; T3- mandacaru + sabiá hay e T4- mandacaru + flor-de-seda hay. The concentrate consisted of 100.0% algaroba (Prosopis juliflora (Sw DC pods. No significant difference was observed for daily weight gain which averaged 88.77 g, and also for voluntary intakes of dry matter, organic matter, ether extract, total carbohydrates, nonfiber carbohydrates, total digestible nutrients and digestible energy in relation to g/day, %BW and g/kg0.75. Significant differences were observed for intake of water in g/day.

  8. Intellectual Engagement, Good Grades and "Doing School": Latest Reports from CEA's What Did You Do in School Today? Initiative

    Science.gov (United States)

    Sefcik, Michael

    2013-01-01

    Are students just "doing school" or are they engaged with their studies? How does a student's level of engagement influence learning, achievement, and teaching? The latest series of What did you do in school today? reports focus on academic outcomes, instructional challenge, and intellectual engagement. The reports reveal there is a…

  9. Primeros registros de la tribu kingsleyini (Crustácea: decápoda: pseudothlphusidae para Colombia

    Directory of Open Access Journals (Sweden)

    Rocha de Campos Martha Helena

    1997-06-01

    Full Text Available This is to report the first record for Colombia of two species of fresh-water crabs of the Kingsleyini Bolt, 1970 tribe. The species Prionothelphusa eliasi Rodríguez, 1980 and Orthothelphusa holthuisi (Rodríguez, 1967 had previously been recorded only for Venezuela.Se establece el primer registro para Colombia de la tribu Kingsleyini Bott, 1970, representado por las especies Prionothelphusa eliasi Rodríguez, 1980 y Orlhothelphusa holthuisi (Rodríguez, 1967. Estas especies solo habían sido registradas para Venezuela.

  10. TIMP-1 and CEA as biomarkers in third-line treatment with irinotecan and cetuximab for metastatic colorectal cancer

    DEFF Research Database (Denmark)

    Spindler, K. L. G.; Christensen, I. J.; Nielsen, H. J.

    2015-01-01

    KRAS wild-type (wt) status determines indication for treatment with combination therapy, including epidermal growth factor receptor (EGFR) inhibitors, but still, the overall response rate in KRAS wt patients is less than 40 %. Consequently, the majority of patients will suffer from substantial side...... in colorectal cancer (CRC). The aim of the present study was to investigate the clinical value of TIMP-1 in patients with metastatic colorectal cancer (mCRC) treated with cetuximab and irinotecan. Patients with chemotherapy-resistant mCRC referred to third-line treatment with cetuximab (initial 400 mg/m(2...

  11. Proceedings of CEAS Forum on Aeroacoustics of Rotors and Propellers, 9-11 June 1999, Rome Italy

    Science.gov (United States)

    1999-06-11

    societies, the Forum will not be limited to aeronautical applications (e.g., helicopter rotors, airplane propellers, tiltrotors). Hence, papers on related fields (e.g., windturbines , fans, ship propellers) are also encouraged.

  12. Efecto insecticida de los aceites esenciales de algunas lamiáceas sobre Tecia solanivora Povolny en condiciones de laboratorio

    Directory of Open Access Journals (Sweden)

    Ramìrez julian Ernesto

    2010-08-01

    Full Text Available La papa, el producto agrícola más importante en la economía de
    los andes colombianos, tiene en la polilla guatemalteca (Tecia
    solanivora Povolny su principal plaga, cuyo control se basa en
    el uso intensivo de plaguicidas. Una alternativa potencial a la
    aplicación de estos insumos es el uso de productos vegetales.
    En condiciones controladas, el presente trabajo evaluó el efecto
    de los aceites esenciales de Ocimum basilicum, O. majorana,
    M. piperita, O. vulgare, P. cablin, R. officinalis, S. officinalis y
    T. vulgaris sobre los huevos, larvas y adultos de T. solanivora
    al ser aplicados directamente sobre los tubérculos, y sobre la
    superficie del suelo. No se encontró ningún efecto de los tratamientos
    sobre el desarrollo larval ni sobre la longevidad de
    los adultos. En las dos modalidades de aplicación estudiadas,
    los aceites de P. cablin y T. vulgaris en una concentración del
    0,25% produjeron una reducción significativa en la viabilidad
    de los huevos. Al aumentar la humedad del suelo y el volumen
    de aplicación de los aceites, los aceites de O. basilicum, O.
    majorana, M. piperita, R. officinalis también tuvieron acción
    ovicida. Estos resultados son evidencia del potencial de estos
    aceites como controladores de Tecia solanivora.

  13. Crecimiento de cactáceas introducidas en Angostillo, Municipio de Paso de Ovejas, Veracruz, México.

    OpenAIRE

    Malpica Vázquez, Alín

    2011-01-01

    En las zonas semisecas, es necesario buscar alternativas de producción agrícola para el mejor aprovechamiento del suelo, por ello, el objetivo fue evaluar el crecimiento de cuatro variedades de Opuntia ficus-indica (L.) Mill nopal de tuna verde (ntv), nopal de verdura (ndv), nopal de tuna roja (ntr) y nopal de tuna sin semilla (ntss), así como las especies columnares Stenocereus stellatus (Pfeiffer) Riccobono, S. griseus (Haworth) Buxbaum y epifita Hylocereus undatus (Haw) Br & R variedades N...

  14. IMPLANTAÇÃO DE BANCO FORRAGEIRO COM LEGUMINOSA HERBÁCEA EM UNIDADE DE PRODUÇÃO FAMILIAR

    OpenAIRE

    Mororó, Dayanne Lustosa; ARAUJO JUNIOR,LUIS MOREIRA DE; Silva Pause, Alzira Gabriela da; Maneschy, Rosana Quaresma

    2013-01-01

    RESUMEN: El uso de bancos de forraje de leguminosas y gramíneas se presenta como una alternativa eficaz a la minimización de la escasez de alimentos durante la estación seca, que puede mantener y / o aumento de la producción de leche. Hemos realizado este estudio con el objetivo de implementar la base de datos de leguminosas forrajeras con la hierba para la suplementación alimentaria de vacas en la estación seca en el proyecto de asentamiento (AP), Belo Horizonte, São Domingos do Araguaia, Pa...

  15. Magnetic measurements of a CEA/IPHI 28.5° dipole for the Linac4 diagnostic beam line

    CERN Document Server

    Buzio, M; Chritin, R; Galbraith, P; Giloteaux, D

    2012-01-01

    This reports summarizes the results of a recent test campaign carried out on a spectrometer dipole for the Linac4 diagnostic line. These results include point-like measurements done with NMR and Hall effect probes and are intended as a cross-check of a more extensive campaign carried out at Sigma Phi. They are aimed specifically at the issue of the reproducibility of the field on different cycling conditions. In the Appendix, a field control algorithm which can be used to guarantee the requested 0.1% reproducibility is spelled out in full detail.

  16. Ethnobotany, phytochennistry and pharmacology of medicinal plants belonging to the genus Baccharis (Astera ceas) used at Ayacucho city

    OpenAIRE

    Aguilar, Enrique; Instituto de Recursos Vegetales y Terapéuticos, Facultad de Farmacia y Bioquímica de la Universidad Nacional Mayor de San Marcos, Lima, Perú.; Anaya, Brita; Universidad Nacional de San Cristóbal de Huamanga.; Alarcón, José; Universidad Nacional de San Cristóbal de Huamanga.; Tinco, Aldo; Universidad Nacional de San Cristóbal de Huamanga.

    2014-01-01

    Spedes from Baccharis genus were studied fo the viewpoint ethnobotanical, chemical and pharmacological which are used as medicinal plants at de Ayacucho depaIllllent. Three species from Baccharis genus were collected from the Quinua district and the Muyurina VaHey (Huamanga province, Ayacucho), during april to june months of 2006. The ethnobotanical study was realized using the Caceres's methodologíe(I996) and the phytochemical study in according to Miranda and Cuellar (2000), prostaglandine ...

  17. Neutronics qualification of the Jules Horowitz reactor fuel by interpretation of the VALMONT experimental program - Transposition of the uncertainties on the reactivity of JHR with JEF2.2 and JEFF3.1.1

    Energy Technology Data Exchange (ETDEWEB)

    Leray, O.; Hudelot, J. P. [DEN Nuclear Projects Laboratory, CEA Cadarache, F-13108 St Paul-Lez-Durance (France); Antony, M. [DEN Experimental Physics Laboratory, CEA Cadarache, F-13108 St Paul-Lez-Durance (France); Doederlein, C. [DEN Nuclear Projects Laboratory, CEA Cadarache, F-13108 St Paul-Lez-Durance (France); Santamarina, A. [DEN Reactor and Cycle Physics Service, CEA Cadarache, F-13108 St Paul-Lez-Durance (France); Bernard, D. [DEN Physical Studies Laboratory, CEA Cadarache, F-13108 St Paul-Lez-Durance (France); Vaglio-Gaudard,