WorldWideScience

Sample records for ca ufo study

  1. UFOs: Observations, Studies and Extrapolations

    CERN Document Server

    Baer, T; Barnes, M J; Bartmann, W; Bracco, C; Carlier, E; Cerutti, F; Dehning, B; Ducimetière, L; Ferrari, A; Ferro-Luzzi, M; Garrel, N; Gerardin, A; Goddard, B; Holzer, E B; Jackson, S; Jimenez, J M; Kain, V; Zimmermann, F; Lechner, A; Mertens, V; Misiowiec, M; Nebot Del Busto, E; Morón Ballester, R; Norderhaug Drosdal, L; Nordt, A; Papotti, G; Redaelli, S; Uythoven, J; Velghe, B; Vlachoudis, V; Wenninger, J; Zamantzas, C; Zerlauth, M; Fuster Martinez, N

    2012-01-01

    UFOs (“ Unidentified Falling Objects”) could be one of the major performance limitations for nominal LHC operation. Therefore, in 2011, the diagnostics for UFO events were significantly improved, dedicated experiments and measurements in the LHC and in the laboratory were made and complemented by FLUKA simulations and theoretical studies. The state of knowledge is summarized and extrapolations for LHC operation in 2012 and beyond are presented. Mitigation strategies are proposed and related tests and measures for 2012 are specified.

  2. MD2036: UFO Dynamics Studies and UFO Fast Detection

    CERN Document Server

    Belanger, Philippe; Valette, Matthieu; Lindstrom, Bjorn Hans Filip; Grob, Laura Katharina; Schmidt, Rudiger; Wollmann, Daniel

    2017-01-01

    UFOs are one of the remaining unknown related to LHC operation. Therefore, improving the understanding of UFO dynamics and validating the developed models against direct beam measurements is of fundamental importance in view of LHC operation at 7 TeV and with HL-LHC beam intensities. If not understood, UFOs could also be a showstopper for future machines such as FCC. This MD demonstrates new methods to study the dynamic behaviour of a calibrated UFO, simulated by the interaction of wire scanners with the beam. The events created during the MD were monitored using diamond BLMs in IR7, providing bunch-by-bunch resolution measurements. The analysis presented herein shows that blown-up bunches can be used to identify the plane of movement of UFOs, that bunch profiles and bunch sizes can be measured with dBLMs with good precision, that simulation of expected losses are in good agreement with measurements for oscillating bunches and that the space resolution of the acquisition system used during the MD is about 10 ...

  3. UFOs in the LHC: Observations, studies and extrapolations

    CERN Document Server

    Baer, T; Cerutti, F; Ferrari, A; Garrel, N; Goddard, B; Holzer, EB; Jackson, S; Lechner, A; Mertens, V; Misiowiec, M; Nebot del Busto, E; Nordt, A; Uythoven, J; Vlachoudis, V; Wenninger, J; Zamantzas, C; Zimmermann, F; Fuster, N

    2012-01-01

    Unidentified falling objects (UFOs) are potentially a major luminosity limitation for nominal LHC operation. They are presumably micrometer sized dust particles which lead to fast beam losses when they interact with the beam. With large-scale increases and optimizations of the beam loss monitor (BLM) thresholds, their impact on LHC availability was mitigated from mid 2011 onwards. For higher beam energy and lower magnet quench limits, the problem is expected to be considerably worse, though. In 2011/12, the diagnostics for UFO events were significantly improved: dedicated experiments and measurements in the LHC and in the laboratory were made and complemented by FLUKA simulations and theoretical studies. The state of knowledge, extrapolations for nominal LHC operation and mitigation strategies are presented

  4. Recent Developments in the Scientific Study of UFO's

    Science.gov (United States)

    Salisbury, Frank B.

    1975-01-01

    Reviews the interest of the last few years, both inside and outside the scientific community, in unidentified flying objects (UFO), placing special emphasis on the extraterrestrial intelligence hypothesis. Cites numerous examples of UFO sightings and urges that the investigation of UFO's proceed in a scientific manner, despite skeptical public…

  5. UFO's in the Classroom?

    Science.gov (United States)

    Coleman, William

    1980-01-01

    This article is in response to the Scientific-Study of Unidentified Flying Objects (UFOs) by the University of Colorado which stated that miseducation was taking place in schools that allowed children to read UFO books. The author encourages the aerospace teacher to allow UFO studies to take place. (SA)

  6. CIA’s Role in the Study of UFOs, 1947-90

    Science.gov (United States)

    1997-01-01

    Intelligence Corn- munity shifted their interest to studying parapsychology and psychic phenomena associated with UFO sightings. CIA officials also looked...on Agency involvement with UFOs in the 1980s. There is a DIA Psychic Center and the NSA studies parapsychology , that branch of psychology that deals

  7. MKI UFOs at Injection

    CERN Document Server

    Baer, T; Bartmann, W; Bracco, C; Carlier, E; Chanavat, C; Drosdal, L; Garrel, N; Goddard, B; Kain, V; Mertens, V; Uythoven, J; Wenninger, J; Zerlauth, M

    2011-01-01

    During the MD, the production mechanism of UFOs at the injection kicker magnets (MKIs) was studied. This was done by pulsing the MKIs on a gap in the circulating beam, which led to an increased number of UFOs. In total 43 UFO type beam loss patterns at the MKIs were observed during the MD. The MD showed that pulsing the MKIs directly induces UFO type beam loss patterns. From the temporal characteristics of the loss profile, estimations about the dynamics of the UFOs are made.

  8. Predictors of injection drug use cessation and relapse in a prospective cohort of young injection drug users in San Francisco, CA (UFO Study).

    Science.gov (United States)

    Evans, Jennifer L; Hahn, Judith A; Lum, Paula J; Stein, Ellen S; Page, Kimberly

    2009-05-01

    Studies of injection drug use cessation have largely sampled adults in drug treatment settings. Little is known about injection cessation and relapse among young injection drug users (IDU) in the community. A total of 365 HCV-negative IDU under age 30 years were recruited by street outreach and interviewed quarterly for a prospective cohort between January 2000 and February 2008. Participants were followed for a total of 638 person-years and 1996 visits. We used survival analysis techniques to identify correlates of injection cessation (> or =3 months) and relapse to injection. 67% of subjects were male, median age was 22 years (interquartile range (IQR) 20-26) and median years injecting was 3.6 (IQR 1.3-6.5). 28.8% ceased injecting during the follow-up period. Among those that ceased injecting, nearly one-half resumed drug injection on subsequent visits, one-quarter maintained injecting cessation, and one-quarter were lost to follow-up. Participating in a drug treatment program in the last 3 months and injecting less than 30 times per month were associated with injection cessation. Injecting heroin or heroin mixed with other drugs, injecting the residue from previously used drug preparation equipment, drinking alcohol, and using benzodiazepines were negatively associated with cessation. Younger age was associated with relapse to injection. These results suggest that factors associated with stopping injecting involve multiple areas of intervention, including access to drug treatment and behavioral approaches to reduce injection and sustain cessation. The higher incidence of relapse in the younger subjects in this cohort underscores the need for earlier detection and treatment programs targeted to adolescents and transition-age youth.

  9. A combined photoelectron spectroscopy and relativistic ab initio studies of the electronic structures of UFO and UFO-

    Science.gov (United States)

    Roy, Soumendra K.; Jian, Tian; Lopez, Gary V.; Li, Wei-Li; Su, Jing; Bross, David H.; Peterson, Kirk A.; Wang, Lai-Sheng; Li, Jun

    2016-02-01

    The observation of the gaseous UFO- anion is reported, which is investigated using photoelectron spectroscopy and relativisitic ab initio calculations. Two strong photoelectron bands are observed at low binding energies due to electron detachment from the U-7sσ orbital. Numerous weak detachment bands are also observed due to the strongly correlated U-5f electrons. The electron affinity of UFO is measured to be 1.27(3) eV. High-level relativistic quantum chemical calculations have been carried out on the ground state and many low-lying excited states of UFO to help interpret the photoelectron spectra and understand the electronic structure of UFO. The ground state of UFO- is linear with an O-U-F structure and a 3H4 spectral term derived from a U 7sσ25fφ15fδ1 electron configuration, whereas the ground state of neutral UFO has a 4H7/2 spectral term with a U 7sσ15fφ15fδ1 electron configuration. Strong electron correlation effects are found in both the anionic and neutral electronic configurations. In the UFO neutral, a high density of electronic states with strong configuration mixing is observed in most of the scalar relativistic and spin-orbit coupled states. The strong electron correlation, state mixing, and spin-orbit coupling of the electronic states make the excited states of UFO very challenging for accurate quantum chemical calculations.

  10. A combined photoelectron spectroscopy and relativistic ab initio studies of the electronic structures of UFO and UFO(-).

    Science.gov (United States)

    Roy, Soumendra K; Jian, Tian; Lopez, Gary V; Li, Wei-Li; Su, Jing; Bross, David H; Peterson, Kirk A; Wang, Lai-Sheng; Li, Jun

    2016-02-28

    The observation of the gaseous UFO(-) anion is reported, which is investigated using photoelectron spectroscopy and relativisitic ab initio calculations. Two strong photoelectron bands are observed at low binding energies due to electron detachment from the U-7sσ orbital. Numerous weak detachment bands are also observed due to the strongly correlated U-5f electrons. The electron affinity of UFO is measured to be 1.27(3) eV. High-level relativistic quantum chemical calculations have been carried out on the ground state and many low-lying excited states of UFO to help interpret the photoelectron spectra and understand the electronic structure of UFO. The ground state of UFO(-) is linear with an O-U-F structure and a (3)H4 spectral term derived from a U 7sσ(2)5fφ(1)5fδ(1) electron configuration, whereas the ground state of neutral UFO has a (4)H(7/2) spectral term with a U 7sσ(1)5fφ(1)5fδ(1) electron configuration. Strong electron correlation effects are found in both the anionic and neutral electronic configurations. In the UFO neutral, a high density of electronic states with strong configuration mixing is observed in most of the scalar relativistic and spin-orbit coupled states. The strong electron correlation, state mixing, and spin-orbit coupling of the electronic states make the excited states of UFO very challenging for accurate quantum chemical calculations.

  11. UFOs in the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Grob, Laura [CERN, Geneva (Switzerland); Technische Universitaet Darmstadt (Germany)

    2016-07-01

    In the Large Hadron Collider (LHC) localized and recurring beam losses have been observed, which usually persist for several hundred microseconds. With increasing beam energy these losses were found to pose a serious risk to the machine availability, as some of these events can cause quenches in the superconducting magnets. The current understanding is that these losses are caused by falling microparticles that interact with the proton beam. To describe these so-called UFOs (unidentified falling objects) and their dynamics, a model was developed starting from the approach that only gravitational and electrostatic forces act on a neutrally charged particle. However, the model's results cannot reproduce the actual data from the LHC's beam loss monitors (BLMs), which indicates a more complex UFO dynamic. Experimental studies and further analysis of the BLM data are planned to investigate the UFO dynamics in greater detail and to understand origins and release mechanisms for microparticles in the LHC beam pipe.

  12. Physical activity in middle-aged women and hip fracture risk: the UFO study.

    Science.gov (United States)

    Englund, U; Nordström, P; Nilsson, J; Bucht, G; Björnstig, U; Hallmans, G; Svensson, O; Pettersson, U

    2011-02-01

    In a population-based case-control study, we demonstrate that middle-aged women who were active with walking or in different physical spare time activities were at lower risk of later sustaining a hip fracture compared to more sedentary women. In middle-aged women participating in the Umeå Fracture and Osteoporosis (UFO) study, we investigated whether physical activity is associated with a subsequent decreased risk of sustaining a hip fracture. The UFO study is a nested case-control study investigating associations between bone markers, lifestyle, and osteoporotic fractures. We identified 81 female hip fracture cases that had reported lifestyle data before they sustained their fracture. Each case was compared with two female controls who were identified from the same cohort and matched for age and week of reporting data, yielding a total cohort of 237 subjects. Mean age at baseline was 57.2 ± 5.0 years, and mean age at fracture was 65.4 ± 6.4 years. Conditional logistic regression analysis with adjustments for height, weight, smoking, and menopausal status showed that subjects who were regularly active with walking or had a moderate or high frequency of physical spare time activities (i.e. berry/mushroom picking and snow shovelling) were at reduced risk of sustaining a hip fracture (OR 0.14; 95% CI; 0.05-0.53 for walking and OR 0.19; 95% CI; 0.08-0.46, OR 0.17, 95% CI; 0.05-0.64 for moderate and high frequency of spare time activities, respectively) compared to more sedentary women. An active lifestyle in middle age seems to reduce the risk of future hip fracture. Possible mechanisms may include improved muscle strength, coordination, and balance resulting in a decreased risk of falling and perhaps also direct skeletal benefits.

  13. MD on UFOs at MKIs and MKQs

    CERN Document Server

    Baer, T; Bartmann, W; Bracco, C; Carlier, E; Dehning, B; Garrel, N; Goddard, B; Jackson, S; Jimenez, M; Kain, V; Mertens, V; Misiowiec, M; Nordt, A; Papotti, G; Uythoven, J; Wenninger, J; Zerlauth, M; Zamantzas, C; Zimmermann, F

    2012-01-01

    UFOs ("Unidentified Falling Objects") are expected to be one of the major known performance limitation of the LHC. In this MD, the production mechanism and the dynamics of UFOs at the injection kicker magnets (MKIs) and the tune kicker magnets (MKQs) were studied. This was done by pulsing the MKIs and MKQs on a gap in the partly filled machine. During the MD, in total 58 UFO-type beam loss patterns were observed directly after pulsing the MKIs. None were observed after pulsing the MKQs, which provides important input for possible mitigation strategies. The temporal and spatial distribution of the UFO events could be determined by using a dedicated BLM Study Buffer, the implications for the UFO dynamics are discussed.

  14. UFOs in the LHC

    CERN Document Server

    Baer, T; Goddard, B; Holzer, E B; Jimenez, J M; Lechner, V; Mertens, V; Nebot Del Busto, E; Nordt, A; Uythoven, J; Velghe, B; Wenninger, J; Zimmermann, F

    2011-01-01

    One of the major known limitations for the performance of the Large Hadron Collider are so called UFOs (Unidentified Falling Objects). UFOs were first observed in July 2010 and caused numerous protection beam dumps since then. They are presumably micrometer sized dust particles that lead to fast beam losses with a duration of about 10 turns when they interact with the beam. In 2011, the diagnostics for such events are highly increased which allows estimations of the properties, dynamics and production mechanisms of the dust particles. The state of knowledge and mitigation strategies are presented.

  15. UFOs: What to Do?

    Science.gov (United States)

    1968-11-01

    understood psychic phenomena (psychic projections, archetypal images, parapsychological phenomena, etc). It is difficult to comment on this possibility...because of the current lack of knowledge of parapsychology . While a (small) number of UFO reports do exhibit (25) aspects of parapsychological

  16. Mortality among young injection drug users in San Francisco: a 10-year follow-up of the UFO study.

    Science.gov (United States)

    Evans, Jennifer L; Tsui, Judith I; Hahn, Judith A; Davidson, Peter J; Lum, Paula J; Page, Kimberly

    2012-02-15

    This study examined associations between mortality and demographic and risk characteristics among young injection drug users in San Francisco, California, and compared the mortality rate with that of the population. A total of 644 young (UFO ("U Find Out") Study, from November 1997 to December 2007. Using the National Death Index, the authors identified 38 deaths over 4,167 person-years of follow-up, yielding a mortality rate of 9.1 (95% confidence interval: 6.6, 12.5) per 1,000 person-years. This mortality rate was 10 times that of the general population. The leading causes of death were overdose (57.9%), self-inflicted injury (13.2%), trauma/accidents (10.5%), and injection drug user-related medical conditions (13.1%). Mortality incidence was significantly higher among those who reported injecting heroin most days in the past month (adjusted hazard ratio = 5.8, 95% confidence interval: 1.4, 24.3). The leading cause of death in this group was overdose, and primary use of heroin was the only significant risk factor for death observed in the study. These findings highlight the continued need for public health interventions that address the risk of overdose in this population in order to reduce premature deaths.

  17. UFOs and Physical Sciences

    Science.gov (United States)

    Teodorani, M.

    1999-03-01

    The psycho-sociological reasons why the academic science is not willing to face operatively and officially a hard problem such as the 'UFO phenomenon', are introduced in the ambit of an episthemological discussion. It is shown how such a phenomenon, due to his peculiar nature, might impose a drastic revision of the laws of physics which are commonly accepted. It is demonstrated how a strict application of the measurement methods which are normally adopted by physics can permit to obtain relevant quantitative results, whatever they are. As an example of such a procedure, the anomalous light phenomenology which reoccurs in the Hessdalen valley in Norway is presented, by showing that it represents so far the ideal worldly physical laboratory for the study of luminous phenomena in the low atmosphere. After describing the multiform morphologic and dynamic characteristics of the luminous component of the phenomenon as they are deduced from visual and photographic reports, the results coming out from the magnetometric, radiometric and radar monitoring operations which were carried out by Project Hessdalen in 1984, are presented in detail. Subsequently, the postumous analysis carried out by the author is shown, by pointing out the clear cohexistence of the magnetic and the optical phenomenology and the apparent correlation of the magnetic component of the phenomenon with maxima of solar activity. In a subsequent phase, the most credited physical theories, which have been proposed so far in order to interpret the phenomenon, are described and discussed, together with 'non-canonical hypotheses'. Finally, it is pointed out how the physical parameters which are expected to be measured with the proper instrumented equipment and aimed tactics and strategies, resemble strictly the methodology which is normally used during astrophysical observations.

  18. Heart Failure and Frailty in the Community-Living Elderly Population: What the UFO Study Will Tell Us

    Directory of Open Access Journals (Sweden)

    Erik Fung

    2018-04-01

    Full Text Available Heart failure and frailty are clinical syndromes that present with overlapping phenotypic characteristics. Importantly, their co-presence is associated with increased mortality and morbidity. While mechanical and electrical device therapies for heart failure are vital for select patients with advanced stage disease, the majority of patients and especially those with undiagnosed heart failure would benefit from early disease detection and prompt initiation of guideline-directed medical therapies. In this article, we review the problematic interactions between heart failure and frailty, introduce a focused cardiac screening program for community-living elderly initiated by a mobile communication device app leading to the Undiagnosed heart Failure in frail Older individuals (UFO study, and discuss how the knowledge of pre-frailty and frailty status could be exploited for the detection of previously undiagnosed heart failure or advanced cardiac disease. The widespread use of mobile devices coupled with increasing availability of novel, effective medical and minimally invasive therapies have incentivized new approaches to heart failure case finding and disease management.

  19. Active commuting reduces the risk of wrist fractures in middle-aged women-the UFO study.

    Science.gov (United States)

    Englund, U; Nordström, P; Nilsson, J; Hallmans, G; Svensson, O; Bergström, U; Pettersson-Kymmer, U

    2013-02-01

    Middle-aged women with active commuting had significantly lower risk for wrist fracture than women commuting by car/bus. Our purpose was to investigate whether a physically active lifestyle in middle-aged women was associated with a reduced risk of later sustaining a low-trauma wrist fracture. The Umeå Fracture and Osteoporosis (UFO) study is a population-based nested case-control study investigating associations between lifestyle and fragility fractures. From a cohort of ~35,000 subjects, we identified 376 female wrist fracture cases who had reported data regarding their commuting habits, occupational, and leisure physical activity, before they sustained their fracture. Each fracture case was compared with at least one control drawn from the same cohort and matched for age and week of reporting data, yielding a total of 778 subjects. Mean age at baseline was 54.3 ± 5.8 years, and mean age at fracture was 60.3 ± 5.8 years. Conditional logistic regression analysis with adjustments for height, body mass index, smoking, and menopausal status showed that subjects with active commuting (especially walking) were at significantly lower risk of sustaining a wrist fracture (OR 0.48; 95 % CI 0.27-0.88) compared with those who commuted by car or bus. Leisure time activities such as dancing and snow shoveling were also associated with a lower fracture risk, whereas occupational activity, training, and leisure walking or cycling were unrelated to fracture risk. This study suggests that active commuting is associated with a lower wrist fracture risk, in middle-aged women.

  20. Images of the Mind and Images for the Eye. An Iconographical Approach to UFO-Mythology

    Directory of Open Access Journals (Sweden)

    Mikael Rothstein

    1996-01-01

    Full Text Available In the study of contemporary new religions and popular religious or metaphysical notions, the iconographical sources are often sadly overlooked. In this article it is the intention to present an iconographical approach to one single, although significantly versatile, aspect of modern, non-traditional mythology, namely the notion of "flying saucers" or UFOs (i.e. Unidentified Flying Objects. The actual UFO-religions may be insignificant in terms of adherence, but the very concept of UFOs holds a strong position in contemporary metaphysics and spirituality, as we find it in the so called New Age movement and elsewhere. Starting with the very notion of strange circular phenomena in the sky, a vast and very differentiated mythology of "flying saucers" or UFOs has developed. As far as the iconographical presentations reflect the narrative structure(s of the UFO myth, these pictures are integrated elements of the UFO story, and sometimes even agents of a further ufological development.

  1. UFOs in the LHC after LS1

    CERN Document Server

    Baer, T; Carlier, E; Cerutti, F; Dehning, B; Ducimetière, L; Ferrari, A; Garrel, N; Gérardin, A; Goddard, B; Holzer, E B; Jackson, S; Jimenez, J M; Kain, V; Lechner, A; Mertens, V; Misiowiec, M; Morón Ballester, R; Nebot del Busto, E; Norderhaug Drosdal, L; Nordt, A; Uythoven, J; Velghe, B; Vlachoudis, V; Wenninger, J; Zamantzas, C; Zimmermann, F; Fuster Martinez, N

    2012-01-01

    UFOs (Unidentified Falling Objects) are potentially a major luminosity limitation for nominal LHC operation. With large-scale increases of the BLM thresholds, their impact on LHC availability was mitigated in the second half of 2011. For higher beam energy and lower magnet quench limits, the problem is expected to be considerably worse, though. Therefore, in 2011, the diagnostics for UFO events were significantly improved, dedicated experiments and measurements in the LHC and in the laboratory were made and complemented by FLUKA simulations and theoretical studies. In this paper, the state of knowledge is summarized and extrapolations for LHC operation after LS1 are presented. Mitigation strategies are proposed and related tests and measures for 2012 are specified.

  2. UFOs in the LHC after LS1

    International Nuclear Information System (INIS)

    Baer, T.; Barnes, M.J.; Carlier, E.; Cerutti, F.; Dehning, B.; Ducimetiere, L.; Ferrari, A.; Garrel, N.; Gerardin, A.; Goddard, B.; Holzer, E.B.; Jackson, S.; Jimenez, J.M.; Kain, V.; Lechner, A.; Mertens, V.; Misiowiec, M.; Moron Ballester, R.; Nebot del Busto, E.; Norderhaug Drosdal, L.; Nordt, A.; Uythoven, J.; Velghe, B.; Vlachoudis, V.; Wenninger, J.; Zamantzas, C.; Zimmermann, F.; Fuster Martinez, N.

    2012-01-01

    UFOs (Unidentified Falling Objects) are potentially a major luminosity limitation for nominal LHC operation. With large-scale increases of the BLM thresholds, their impact on LHC availability was mitigated in the second half of 2011. For higher beam energy and lower magnet quench limits, the problem is expected to be considerably worse, though. Therefore, in 2011, the diagnostics for UFO events were significantly improved, dedicated experiments and measurements in the LHC and in the laboratory were made and complemented by FLUKA simulations and theoretical studies. In this paper, the state of knowledge is summarized and extrapolations for LHC operation after LS1 are presented. Mitigation strategies are proposed and related tests and measures for 2012 are specified. (authors)

  3. UFO Literature for the Serious Ufologist.

    Science.gov (United States)

    Eberhart, George M.

    1980-01-01

    Discusses the differences between the serious ufologist and the interested novice, reviews essential reference works and journals dealing with UFOs, and addresses problems that libraries have in collecting UFO literature. (FM)

  4. Hypothesis on the nature of atmospheric UFOs

    Science.gov (United States)

    Mukharev, L. A.

    1991-08-01

    A hypothesis is developed according to which the atmospheric UFO phenomenon has an electromagnetic nature. It is suggested that an atmospheric UFO is an agglomeration of charged atmospheric dust within which there exists a slowly damped electromagnetic field. This field is considered to be the source of the observed optical effects and the motive force of the UFO.

  5. UFO - The Universal FEYNRULES Output

    Science.gov (United States)

    Degrande, Céline; Duhr, Claude; Fuks, Benjamin; Grellscheid, David; Mattelaer, Olivier; Reiter, Thomas

    2012-06-01

    We present a new model format for automatized matrix-element generators, the so-called Universal FEYNRULES Output (UFO). The format is universal in the sense that it features compatibility with more than one single generator and is designed to be flexible, modular and agnostic of any assumption such as the number of particles or the color and Lorentz structures appearing in the interaction vertices. Unlike other model formats where text files need to be parsed, the information on the model is encoded into a PYTHON module that can easily be linked to other computer codes. We then describe an interface for the MATHEMATICA package FEYNRULES that allows for an automatic output of models in the UFO format.

  6. An activated form of UFO alters leaf development and produces ectopic floral and inflorescence meristems.

    Directory of Open Access Journals (Sweden)

    Eddy Risseeuw

    Full Text Available Plants are unique in their ability to continuously produce new meristems and organ primordia. In Arabidopsis, the transcription factor LEAFY (LFY functions as a master regulator of a gene network that is important for floral meristem and organ specification. UNUSUAL FLORAL ORGANS (UFO is a co-activator of LEAFY and is required for proper activation of APETALA3 in the floral meristem during the specification of stamens and petals. The ufo mutants display defects in other parts of the flower and the inflorescence, suggestive of additional roles. Here we show that the normal determinacy of the developing Arabidopsis leaves is affected by the expression of a gain-of-function UFO fusion protein with the VP16 transcriptional activator domain. In these lines, the rosette and cauline leaf primordia exhibit reiterated serration, and upon flowering produce ectopic meristems that develop into flowers, bract leaves and inflorescences. These striking phenotypes reveal that developing leaves maintain the competency to initiate flower and inflorescence programs. Furthermore, the gain-of-function phenotypes are dependent on LFY and the SEPALLATA (SEP MADS-box transcription factors, indicative of their functional interactions with UFO. The findings of this study also suggest that UFO promotes the establishment of the lateral meristems and primordia in the peripheral zone of the apical and floral meristems by enhancing the activity of LFY. These novel phenotypes along with the mutant phenotypes of UFO orthologs in other plant species suggest a broader function for UFO in plants.

  7. An activated form of UFO alters leaf development and produces ectopic floral and inflorescence meristems.

    Science.gov (United States)

    Risseeuw, Eddy; Venglat, Prakash; Xiang, Daoquan; Komendant, Kristina; Daskalchuk, Tim; Babic, Vivijan; Crosby, William; Datla, Raju

    2013-01-01

    Plants are unique in their ability to continuously produce new meristems and organ primordia. In Arabidopsis, the transcription factor LEAFY (LFY) functions as a master regulator of a gene network that is important for floral meristem and organ specification. UNUSUAL FLORAL ORGANS (UFO) is a co-activator of LEAFY and is required for proper activation of APETALA3 in the floral meristem during the specification of stamens and petals. The ufo mutants display defects in other parts of the flower and the inflorescence, suggestive of additional roles. Here we show that the normal determinacy of the developing Arabidopsis leaves is affected by the expression of a gain-of-function UFO fusion protein with the VP16 transcriptional activator domain. In these lines, the rosette and cauline leaf primordia exhibit reiterated serration, and upon flowering produce ectopic meristems that develop into flowers, bract leaves and inflorescences. These striking phenotypes reveal that developing leaves maintain the competency to initiate flower and inflorescence programs. Furthermore, the gain-of-function phenotypes are dependent on LFY and the SEPALLATA (SEP) MADS-box transcription factors, indicative of their functional interactions with UFO. The findings of this study also suggest that UFO promotes the establishment of the lateral meristems and primordia in the peripheral zone of the apical and floral meristems by enhancing the activity of LFY. These novel phenotypes along with the mutant phenotypes of UFO orthologs in other plant species suggest a broader function for UFO in plants.

  8. Close encounters: an examination of UFO experiences.

    Science.gov (United States)

    Spanos, N P; Cross, P A; Dickson, K; DuBreuil, S C

    1993-11-01

    Ss who reported UFO experiences were divided into those whose experiences were nonintense (e.g., seeing lights and shapes in the sky) and those whose experiences were intense (e.g., seeing and communicating with aliens or missing time). On a battery of objective tests Ss in these 2 groups did not score as more psychopathological, less intelligent, or more fantasy prone and hypnotizable than a community comparison group or a student comparison group. However, Ss in the UFO groups believed more strongly in space alien visitation than did comparison Ss. The UFO experiences of Ss in the intense group were more frequently sleep-related than the experiences of Ss in the nonintense group. Among the combined UFO Ss, intensity of UFO experiences correlated significantly with inventories that assessed proneness toward fantasy and unusual sensory experiences. Implications are discussed.

  9. UFO Religions – Beginnings and Main Forms

    Directory of Open Access Journals (Sweden)

    Danijel Sinani

    2016-02-01

    Full Text Available This paper looks at UFO religions, and considers the major factors that have played a role in the emergence and development of these alternative religious movements - from reports of close encounters of the third and fourth kinds and science fiction production, to alternative ideological elaborations of contacts with extraterrestrial worlds. It looks at the basic theological premises, iconography, activities, and, more generally, cultural precepts of several UFO religious movements (the Aetherius Society, Heaven's Gate, Unarius, the Raelian movement. Attention is drawn to the religious connotations of UFO discourse, and its motifs of "otherness" and "supernaturalness". In addition, the relation between the roles and themes promoted within the contactee movement and the accounts of persons claiming to have been abducted by aliens is explored. Finally, the paper highlights the key existential questions and identifies the themes and motifs with which UFO religionists present themselves to the public.

  10. The ASK1 gene regulates B function gene expression in cooperation with UFO and LEAFY in Arabidopsis.

    Science.gov (United States)

    Zhao, D; Yu, Q; Chen, M; Ma, H

    2001-07-01

    The Arabidopsis floral regulatory genes APETALA3 (AP3) and PISTILLATA (PI) are required for the B function according to the ABC model for floral organ identity. AP3 and PI expression are positively regulated by the LEAFY (LFY) and UNUSUAL FLORAL ORGANS (UFO) genes. UFO encodes an F-box protein, and we have shown previously that UFO genetically interacts with the ASK1 gene encoding a SKP1 homologue; both the F-box containing protein and SKP1 are subunits of ubiquitin ligases. We show here that the ask1-1 mutation can enhance the floral phenotypes of weak lfy and ap3 mutants; therefore, like UFO, ASK1 also interacts with LFY and AP3 genetically. Furthermore, our results from RNA in situ hybridizations indicate that ASK1 regulates early AP3 and PI expression. These results support the idea that UFO and ASK1 together positively regulate AP3 and PI expression. We propose that the UFO and ASK1 proteins are components of a ubiquitin ligase that mediates the proteolysis of a repressor of AP3 and PI expression. Our genetic studies also indicate that ASK1 and UFO play a role in regulating the number of floral organ primordia, and we discuss possible mechanisms for such a regulation.

  11. Trends in methamphetamine use in young injection drug users in San Francisco from 1998 to 2004: the UFO Study.

    Science.gov (United States)

    Inglez-Dias, Aline; Hahn, Judith A; Lum, Paula J; Evans, Jennifer; Davidson, Peter; Page-Shafer, Kimberly

    2008-05-01

    To describe temporal trends in methamphetamine use among young injection drug users (IDU) in San Francisco. Secondary analysis of cross-sectional baseline data collected for a longitudinal study of young IDU from 1998 to 2004. Participants were 1445 young IDU (<30 years old) who reported injection in the previous month, English-speaking, and recruited by street outreach methods. We examined trends for: lifetime (ever) and recent (30-day) methamphetamine use, including injected and non-injected, and by age group and sexual risk behaviour [men who have sex with men injecting drug users (MSM-IDU), male IDU (non-MSM) and female IDU]. In 1998, 1999, 2000, 2001, 2003 and 2004 we interviewed 237, 276, 431, 310, 147 and 44 participants, respectively. Overall, median age was 22 years [interquartile range (IQR) 20-25], 30.3% were women and median duration of injecting was 4.4 years (IQR 2-7). Prevalence of methamphetamine use was high, with 50.1% reporting recent injection, but overall there were no temporal increases in reported 'ever' injected use. Recent methamphetamine injection (past 30 days) increased significantly, and peaked at 60% in 2003. MSM-IDU had higher methamphetamine injection ever (92.3%) and recently (59.5%) compared to heterosexual male (non-MSM) IDU (81.6% and 47.3%, respectively) and to female IDU (78.4% and 46.1%, respectively). Despite reports of ubiquitous increases in methamphetamine use, there were no significant increases in 6 years in ever injecting methamphetamine overall among young IDU. MSM-IDU who reported the highest methamphetamine use overall reported some increases in recent injected use. The methamphetamine 'epidemic' was probably under way among young IDU earlier than other populations.

  12. Technology. Theosophy. Theology: The Religious Character of UFO Movements

    Directory of Open Access Journals (Sweden)

    Danijel Sinani

    2016-02-01

    Full Text Available This paper considers the most important factors that have played a role in the emergence and development of UFO religiosity and UFO alternative religious movements, from occult, spiritualist and theosophical teachings, to alternative ideas and debates on the origin of mankind. By analyzing the basic theological premises, the paper discusses the basic religious and culturological paradigms to be found in UFO movements. It also shows how a major part of their corpus can be recognized in existing "traditional" religious groups, and suggests that UFO religions represent just another variation on the numerous concepts that offer answers to key existential questions.

  13. SARAH 3.2: Dirac gauginos, UFO output, and more

    Science.gov (United States)

    Staub, Florian

    2013-07-01

    SARAH is a Mathematica package optimized for the fast, efficient and precise study of supersymmetric models beyond the MSSM: a new model can be defined in a short form and all vertices are derived. This allows SARAH to create model files for FeynArts/FormCalc, CalcHep/CompHep and WHIZARD/O'Mega. The newest version of SARAH now provides the possibility to create model files in the UFO format which is supported by MadGraph 5, MadAnalysis 5, GoSam, and soon by Herwig++. Furthermore, SARAH also calculates the mass matrices, RGEs and 1-loop corrections to the mass spectrum. This information is used to write source code for SPheno in order to create a precision spectrum generator for the given model. This spectrum-generator-generator functionality as well as the output of WHIZARD and CalcHep model files has seen further improvement in this version. Also models including Dirac gauginos are supported with the new version of SARAH, and additional checks for the consistency of the implementation of new models have been created. Program summaryProgram title:SARAH Catalogue identifier: AEIB_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEIB_v2_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 3 22 411 No. of bytes in distributed program, including test data, etc.: 3 629 206 Distribution format: tar.gz Programming language: Mathematica. Computer: All for which Mathematica is available. Operating system: All for which Mathematica is available. Classification: 11.1, 11.6. Catalogue identifier of previous version: AEIB_v1_0 Journal reference of previous version: Comput. Phys. Comm. 182 (2011) 808 Does the new version supersede the previous version?: Yes, the new version includes all known features of the previous version but also provides the new features mentioned below

  14. Towards Ontological Foundations for Agent Modeling Concepts using UFO

    NARCIS (Netherlands)

    Guizzardi, G.; Wagner, Gerd

    Foundational ontologies provide the basic concepts upon which any domain-specific ontology is built. This paper presents a new foundational ontology, UFO, and shows how it can be used as a foundation of agent concepts and for evaluating agent-oriented modeling methods. UFO is derived from a

  15. A Highly Expressed High-Molecular-Weight S-Layer Complex of Pelosinus sp. Strain UFO1 Binds Uranium

    Energy Technology Data Exchange (ETDEWEB)

    Thorgersen, Michael P. [Univ. of Georgia, Athens, GA (United States). Dept. of Biochemistry and Molecular Biology; Lancaster, W. Andrew [Univ. of Georgia, Athens, GA (United States). Dept. of Biochemistry and Molecular Biology; Rajeev, Lara [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division; Ge, Xiaoxuan [Univ. of Georgia, Athens, GA (United States). Dept. of Biochemistry and Molecular Biology; Vaccaro, Brian J. [Univ. of Georgia, Athens, GA (United States). Dept. of Biochemistry and Molecular Biology; Poole, Farris L. [Univ. of Georgia, Athens, GA (United States). Dept. of Biochemistry and Molecular Biology; Arkin, Adam P. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division; Mukhopadhyay, Aindrila [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division; Adams, Michael W. W. [Univ. of Georgia, Athens, GA (United States). Dept. of Biochemistry and Molecular Biology

    2016-12-02

    Cell suspensions of Pelosinus sp. strain UFO1 were previously shown, using spectroscopic analysis, to sequester uranium as U(IV) complexed with carboxyl and phosphoryl group ligands on proteins. The goal of our present study was to characterize the proteins involved in uranium binding. Virtually all of the uranium in UFO1 cells was associated with a heterodimeric protein, which was termed the uranium-binding complex (UBC). The UBC was composed of two S-layer domain proteins encoded by UFO1_4202 and UFO1_4203. Samples of UBC purified from the membrane fraction contained 3.3 U atoms/heterodimer, but significant amounts of phosphate were not detected. The UBC had an estimated molecular mass by gel filtration chromatography of 15 MDa, and it was proposed to contain 150 heterodimers (UFO1_4203 and UFO1_4202) and about 500 uranium atoms. The UBC was also the dominant extracellular protein, but when purified from the growth medium, it contained only 0.3 U atoms/heterodimer. The two genes encoding the UBC were among the most highly expressed genes within the UFO1 genome, and their expressions were unchanged by the presence or absence of uranium. Therefore, the UBC appears to be constitutively expressed and is the first line of defense against uranium, including by secretion into the extracellular medium. Although S-layer proteins were previously shown to bind U(VI), here we showed that U(IV) binds to S-layer proteins, we identified the proteins involved, and we quantitated the amount of uranium bound. Widespread uranium contamination from industrial sources poses hazards to human health and to the environment. Here in this paper, we identified a highly abundant uranium-binding complex (UBC) from Pelosinus sp. strain UFO1. The complex makes up the primary protein component of the S-layer of strain UFO1 and binds 3.3 atoms of U(IV) per heterodimer. Finally, while other bacteria have been shown to bind U(VI) on their S-layer, we demonstrate here an example of U(IV) bound by

  16. Kontrolle der Expression des UNUSUAL FLORAL ORGANS (UFO) Gens in Arabidopsis thaliana

    OpenAIRE

    Hobe, Martin

    2004-01-01

    Die vorliegende Arbeit befaßt sich mit der Kontrolle des Expressionsmusters des UNUSUAL FLORAL ORGANS (UFO) Gens von Arabidopsis thaliana. UFO wird im Sproß- und Blütenmeristemen aller Entwicklungsstadien der Pflanze exprimiert. In Blütenmeristemen agiert UFO als Kofaktor von LEAFY (LFY) bei der Aktivierung der Organidentitätsgene des zweiten und dritten Wirtels. UFO stellt also einen generellen Faktor der Musterbildung in Meristemen dar. Um regulatorische Gene, die die Expression von UFO bee...

  17. LHC experiences close encounters with UFOs

    CERN Multimedia

    Mike Lamont for the LHC Team

    2011-01-01

    On 29 May, yet another record was set as 1092 bunches per beam were injected into the LHC, hitting a peak luminosity of 1.26x1033 cm-2 s-1. While running at 3.5 TeV each beam now packs a total energy of over 70 MJ – equivalent to a TGV travelling at a 70 kph.   Operators in the LHC Control Centre happily show off their display screens after succesfully injecting 1092 bunches injected into the machine for the first time.  As the total beam intensity has been pushed up, the LHC has encountered a number of related problems, such as the so-called UFOs (Unidentified Falling Objects). These are thought to be dust particles falling through the beam, causing localized beam loss. The losses can push nearby beam loss monitors over the threshold and dump the beam. This is more of an annoyance than a danger for the LHC, but UFOs do reduce the operational efficiency of the machine. Despite this, the luminosity delivered to the experiments has steadily increased. On three occasions there ha...

  18. Searching for the UV counterpart of the extraordinary X-ray UFO in the NLSy1 IRAS17020+4544

    Science.gov (United States)

    Krongold, Yair

    2017-08-01

    We recently reported the first unambiguous discovery in high resolution X-ray data of an ultra fast outflow (UFO) with velocity .1c. This wind, in Narrow Line Seyfert 1 galaxy IRAS17020+4544, represents so far the most compelling detection of an UFO, with many different absorption lines that give rise to very high significance detections. The charge states that form the wind clearly indicate a large range of ionization states in the gas, and significant absorption by Ly alpha, C IV, Si IV and N V (among other ions) is expected in the UV band. The goal of our proposed program is to observe an characterize the best X-ray detected UFO in the UV. These observations are crucial to study in great detail the UFO phenomenon, and understand its nature and its relation to the narrow absorption line low velocity systems. Only through detection of Ly alpha absorption in the UV data, measurements of the metallicity of these winds will be possible. The proposed program will help guide new theoretical models of UFOs origins, beyond the simple actual picture that predicts only very high ionization Fe absorption. UV data are required to understand the wind nature and launching mechanism (whether due to radiation pressure via line or continuum opacity, or magnetic forces). Fully characterizing the wind properties will put stronger constraints in the mass outflow and kinetic outflow rates of these systems, as well as in their geometry. Such estimates will give a much clearer picture of UFOs feedback potential, and will provide clues on the feedback mode in action (e.g. energy conserving vs. momentum conserving).

  19. Yet another UFO in the X-ray spectrum of a high-z lensed QSO

    Science.gov (United States)

    Dadina, M.; Vignali, C.; Cappi, M.; Lanzuisi, G.; Ponti, G.; Torresi, E.; De Marco, B.; Chartas, G.; Giustini, M.

    2018-02-01

    Aim. Ultra-fast outflows (UFO) appear to be common in local active galactic nuclei (AGN) and may be powerful enough (Ėkin ≥ 1% of Lbol) to effectively quench the star formation in their host galaxies. To test feedback models based on AGN outflows, it is mandatory to investigate UFOs near the peak of AGN activity, that is, at high-z where only a few studies are available to date. Methods: UFOs produce Fe resonant absorption lines measured above ≈7 keV. The most critical problem in detecting such features in distant objects is the difficulty in obtaining X-ray data with sufficient signal-to-noise. We therefore selected a distant QSO that gravitational lensing made bright enough for these purposes, the z = 2.64 QSO MG J0414+0534, and observed it with XMM-Newton for ≈78 ks. Results: The X-ray spectrum of MG J0414+0534 is complex and shows signatures of cold absorption (NH ≈ 4 × 1022 cm-2) and of the presence of an iron emission line (E ≈ 6.4 keV, EW = 95 ± 53 eV) consistent with it originating in the cold absorber. Our main result, however, is the robust detection (more than 5σ) of an absorption line at Eint ≈ 9.2 keV (Eobs ≈ 2.5 keV observer frame). If interpreted as due to FeXXVI, it implies gas outflowing at vout ≈ 0.3c. To our knowledge, this is the first detection of an UFO in a radio-loud quasar at z ≥ 1.5. We estimated that the UFO mechanical output is Ėkin ≈ 2.5Lbol with ṗout/ṗrad ≈ 17 indicating that it is capable of installing significant feedback between the super-massive black hole and the bulge of the host galaxy. We argue that this also suggests a magnetic driving origin of the UFO.

  20. Ultra-fast outflows (aka UFOs) from AGNs and QSOs

    OpenAIRE

    Cappi, M.; Tombesi, F.; Giustini, M.

    2013-01-01

    During the last decade, strong observational evidence has been accumulated for the existence of massive, high velocity winds/outflows (aka Ultra Fast Outflows, UFOs) in nearby AGNs and in more distant quasars. Here we briefly review some of the most recent developments in this field and discuss the relevance of UFOs for both understanding the physics of accretion disk winds in AGNs, and for quantifying the global amount of AGN feedback on the surrounding medium.

  1. Ultra-fast outflows (aka UFOs) from AGNs and QSOs

    Science.gov (United States)

    Cappi, M.; Tombesi, F.; Giustini, M.

    During the last decade, strong observational evidence has been accumulated for the existence of massive, high velocity winds/outflows (aka Ultra Fast Outflows, UFOs) in nearby AGNs and in more distant quasars. Here we briefly review some of the most recent developments in this field and discuss the relevance of UFOs for both understanding the physics of accretion disk winds in AGNs, and for quantifying the global amount of AGN feedback on the surrounding medium.

  2. The genomic structure of the human UFO receptor.

    Science.gov (United States)

    Schulz, A S; Schleithoff, L; Faust, M; Bartram, C R; Janssen, J W

    1993-02-01

    Using a DNA transfection-tumorigenicity assay we have recently identified the UFO oncogene. It encodes a tyrosine kinase receptor characterized by the juxtaposition of two immunoglobulin-like and two fibronectin type III repeats in its extracellular domain. Here we describe the genomic organization of the human UFO locus. The UFO receptor is encoded by 20 exons that are distributed over a region of 44 kb. Different isoforms of UFO mRNA are generated by alternative splicing of exon 10 and differential usage of two imperfect polyadenylation sites resulting in the presence or absence of 1.5-kb 3' untranslated sequences. Primer extension and S1 nuclease analyses revealed multiple transcriptional initiation sites including a major site 169 bp upstream of the translation start site. The promoter region is GC rich, lacks TATA and CAAT boxes, but contains potential recognition sites for a variety of trans-acting factors, including Sp1, AP-2 and the cyclic AMP response element-binding protein. Proto-UFO and its oncogenic counterpart exhibit identical cDNA and promoter regions sequences. Possible modes of UFO activation are discussed.

  3. UFO: an Arabidopsis gene involved in both floral meristem and floral organ development.

    Science.gov (United States)

    Levin, J Z; Meyerowitz, E M

    1995-05-01

    We describe the role of the UNUSUAL FLORAL ORGANS (UFO) gene in Arabidopsis floral development based on a genetic and molecular characterization of the phenotypes of nine ufo alleles. UFO is required for the proper identity of the floral meristem and acts in three different aspects of the process that distinguishes flowers from shoots. UFO is involved in establishing the whorled pattern of floral organs, controlling the determinacy of the floral meristem, and activating the APETALA3 and PISTILLATA genes required for petal and stamen identity. In many respects, UFO acts in a manner similar to LEAFY, but the ufo mutant phenotype also suggests an additional role for UFO in defining boundaries within the floral primordia or controlling cell proliferation during floral organ growth. Finally, genetic interactions that prevent flower formation and lead to the generation of filamentous structures implicate UFO as a member of a new, large, and diverse class of genes in Arabidopsis necessary for flower formation.

  4. UFOs and nukes. Extraordinary encounters at nuclear weapons sites

    International Nuclear Information System (INIS)

    Hastings, Robert L.

    2015-01-01

    Everyone knows about the reported recovery of a crashed alien spaceship near Roswell, New Mexico in July 1947. However, most people are unaware that, at the time of the incident, Roswell Army Airfield was home to the world's only atomic bomber squadron, the 509th Bomb Group. Was this merely a coincidence? During the Cold War, the United States and the Soviet Union built thousands of the far more destructive hydrogen bombs, some of them a thousand times as destructive as the first atomic bombs dropped on Japan. If the nuclear standoff between the superpowers had erupted into World War III, human civilization - and perhaps the very survival of our species - would have been at risk. Did this ominous state of affairs come to the attention of outside observers? Was there a connection between the atomic bomber squadron based at Roswell and the reported crash of a UFO nearby? Did those who pilot the UFOs monitor the superpowers' nuclear arms race during the dangerous Cold War era? Do they scrutinize American and Russian weapons sites even now? UFOs and Nukes provides the startling and sometimes shocking answers to these questions. Veteran researcher Robert Hastings has investigated nuclear weapons-related UFO incidents for more than three decades and has interviewed more than 120 ex-US Air Force personnel, from former Airmen to retired Colonels, who witnessed extraordinary UFO encounters at nuclear weapons sites. Their amazing stories are presented here.

  5. Separable roles of UFO during floral development revealed by conditional restoration of gene function.

    Science.gov (United States)

    Laufs, Patrick; Coen, Enrico; Kronenberger, Jocelyne; Traas, Jan; Doonan, John

    2003-02-01

    The UNUSUAL FLORAL ORGANS (UFO) gene is required for several aspects of floral development in Arabidopsis including specification of organ identity in the second and third whorls and the proper pattern of primordium initiation in the inner three whorls. UFO is expressed in a dynamic pattern during the early phases of flower development. Here we dissect the role of UFO by ubiquitously expressing it in ufo loss-of-function flowers at different developmental stages and for various durations using an ethanol-inducible expression system. The previously known functions of UFO could be separated and related to its expression at specific stages of development. We show that a 24- to 48-hour period of UFO expression from floral stage 2, before any floral organs are visible, is sufficient to restore normal petal and stamen development. The earliest requirement for UFO is during stage 2, when the endogenous UFO gene is transiently expressed in the centre of the wild-type flower and is required to specify the initiation patterns of petal, stamen and carpel primordia. Petal and stamen identity is determined during stages 2 or 3, when UFO is normally expressed in the presumptive second and third whorl. Although endogenous UFO expression is absent from the stamen whorl from stage 4 onwards, stamen identity can be restored by UFO activation up to stage 6. We also observed floral phenotypes not observed in loss-of-function or constitutive gain-of-function backgrounds, revealing additional roles of UFO in outgrowth of petal primordia.

  6. UFOs and nukes. Extraordinary encounters at nuclear weapons sites; UFOs und Atomwaffen. Unheimliche Begegnungen in der Naehe von Nuklearwaffendepots

    Energy Technology Data Exchange (ETDEWEB)

    Hastings, Robert L.

    2015-07-01

    Everyone knows about the reported recovery of a crashed alien spaceship near Roswell, New Mexico in July 1947. However, most people are unaware that, at the time of the incident, Roswell Army Airfield was home to the world's only atomic bomber squadron, the 509th Bomb Group. Was this merely a coincidence? During the Cold War, the United States and the Soviet Union built thousands of the far more destructive hydrogen bombs, some of them a thousand times as destructive as the first atomic bombs dropped on Japan. If the nuclear standoff between the superpowers had erupted into World War III, human civilization - and perhaps the very survival of our species - would have been at risk. Did this ominous state of affairs come to the attention of outside observers? Was there a connection between the atomic bomber squadron based at Roswell and the reported crash of a UFO nearby? Did those who pilot the UFOs monitor the superpowers' nuclear arms race during the dangerous Cold War era? Do they scrutinize American and Russian weapons sites even now? UFOs and Nukes provides the startling and sometimes shocking answers to these questions. Veteran researcher Robert Hastings has investigated nuclear weapons-related UFO incidents for more than three decades and has interviewed more than 120 ex-US Air Force personnel, from former Airmen to retired Colonels, who witnessed extraordinary UFO encounters at nuclear weapons sites. Their amazing stories are presented here.

  7. Flight and abduction in witchcraft and UFO lore.

    Science.gov (United States)

    Musgrave, J B; Houran, J

    2000-04-01

    The lore surrounding the mythical Witches' Sabbat and contemporary reports of UFO abductions share three main characteristics: the use of masks, the appearance of "Men in Black," and references to flight and abduction. We review these three commonalities with particular focus on the aspect of flight and abduction. We argue that narratives of the Witches' Sabbat and UFO abductions share the same basic structure, common symbolism, and serve the same psychological needs of providing a coherent explanation for anomalous (ambiguous) experiences while simultaneously giving the experient a sense of freedom, release, and escape from the self. This pattern of similarities suggests the possibility that UFO abductions are a modern version of tales of flight to the Sabbat.

  8. BAL QSOs AND EXTREME UFOs: THE EDDINGTON CONNECTION

    International Nuclear Information System (INIS)

    Zubovas, Kastytis; King, Andrew

    2013-01-01

    We suggest a common physical origin connecting the fast, highly ionized winds (UFOs) seen in nearby active galactic nuclei (AGNs), and the slower and less ionized winds of broad absorption line (BAL) QSOs. The primary difference is the mass-loss rate in the wind, which is ultimately determined by the rate at which mass is fed toward the central supermassive black hole (SMBH) on large scales. This is below the Eddington accretion rate in most UFOs, and slightly super-Eddington in extreme UFOs such as PG1211+143, but ranges up to ∼10-50 times this in BAL QSOs. For UFOs this implies black hole accretion rates and wind mass-loss rates which are at most comparable to Eddington, giving fast, highly ionized winds. In contrast, BAL QSO black holes have mildly super-Eddington accretion rates, and drive winds whose mass-loss rates are significantly super-Eddington, and so are slower and less ionized. This picture correctly predicts the velocities and ionization states of the observed winds, including the recently discovered one in SDSS J1106+1939. We suggest that luminous AGNs may evolve through a sequence from BAL QSO through LoBAL to UFO-producing Seyfert or quasar as their Eddington factors drop during the decay of a bright accretion event. LoBALs correspond to a short-lived stage in which the AGN radiation pressure largely evacuates the ionization cone, but before the large-scale accretion rate has dropped to the Eddington value. We show that sub-Eddington wind rates would produce an M-σ relation lying above that observed. We conclude that significant SMBH mass growth must occur in super-Eddington phases, either as BAL QSOs, extreme UFOs, or obscured from direct observation.

  9. BAL QSOs AND EXTREME UFOs: THE EDDINGTON CONNECTION

    Energy Technology Data Exchange (ETDEWEB)

    Zubovas, Kastytis; King, Andrew, E-mail: kastytis.zubovas@ftmc.lt [Theoretical Astrophysics Group, University of Leicester, Leicester LE1 7RH (United Kingdom)

    2013-05-20

    We suggest a common physical origin connecting the fast, highly ionized winds (UFOs) seen in nearby active galactic nuclei (AGNs), and the slower and less ionized winds of broad absorption line (BAL) QSOs. The primary difference is the mass-loss rate in the wind, which is ultimately determined by the rate at which mass is fed toward the central supermassive black hole (SMBH) on large scales. This is below the Eddington accretion rate in most UFOs, and slightly super-Eddington in extreme UFOs such as PG1211+143, but ranges up to {approx}10-50 times this in BAL QSOs. For UFOs this implies black hole accretion rates and wind mass-loss rates which are at most comparable to Eddington, giving fast, highly ionized winds. In contrast, BAL QSO black holes have mildly super-Eddington accretion rates, and drive winds whose mass-loss rates are significantly super-Eddington, and so are slower and less ionized. This picture correctly predicts the velocities and ionization states of the observed winds, including the recently discovered one in SDSS J1106+1939. We suggest that luminous AGNs may evolve through a sequence from BAL QSO through LoBAL to UFO-producing Seyfert or quasar as their Eddington factors drop during the decay of a bright accretion event. LoBALs correspond to a short-lived stage in which the AGN radiation pressure largely evacuates the ionization cone, but before the large-scale accretion rate has dropped to the Eddington value. We show that sub-Eddington wind rates would produce an M-{sigma} relation lying above that observed. We conclude that significant SMBH mass growth must occur in super-Eddington phases, either as BAL QSOs, extreme UFOs, or obscured from direct observation.

  10. BAL QSOs and Extreme UFOs: The Eddington Connection

    Science.gov (United States)

    Zubovas, Kastytis; King, Andrew

    2013-05-01

    We suggest a common physical origin connecting the fast, highly ionized winds (UFOs) seen in nearby active galactic nuclei (AGNs), and the slower and less ionized winds of broad absorption line (BAL) QSOs. The primary difference is the mass-loss rate in the wind, which is ultimately determined by the rate at which mass is fed toward the central supermassive black hole (SMBH) on large scales. This is below the Eddington accretion rate in most UFOs, and slightly super-Eddington in extreme UFOs such as PG1211+143, but ranges up to ~10-50 times this in BAL QSOs. For UFOs this implies black hole accretion rates and wind mass-loss rates which are at most comparable to Eddington, giving fast, highly ionized winds. In contrast, BAL QSO black holes have mildly super-Eddington accretion rates, and drive winds whose mass-loss rates are significantly super-Eddington, and so are slower and less ionized. This picture correctly predicts the velocities and ionization states of the observed winds, including the recently discovered one in SDSS J1106+1939. We suggest that luminous AGNs may evolve through a sequence from BAL QSO through LoBAL to UFO-producing Seyfert or quasar as their Eddington factors drop during the decay of a bright accretion event. LoBALs correspond to a short-lived stage in which the AGN radiation pressure largely evacuates the ionization cone, but before the large-scale accretion rate has dropped to the Eddington value. We show that sub-Eddington wind rates would produce an M-σ relation lying above that observed. We conclude that significant SMBH mass growth must occur in super-Eddington phases, either as BAL QSOs, extreme UFOs, or obscured from direct observation.

  11. UFO-a multi-analyser option for IN12

    Science.gov (United States)

    Schmidt, Wolfgang; Rheinstädter, Maikel C.; Raymond, Stephane; Ohl, Michael

    2004-07-01

    The IN12 instrument is operated by FZ Jülich in collaboration with CEA Grenoble as a CRG-B instrument at the Institut Laue Langevin in Grenoble. As a three-axis spectrometer for cold neutrons it is dedicated for high-resolution studies of low-energy excitations. In the past years the instrument has been continuously improved and it has demonstrated its excellent performance for neutron scattering research. To meet further challenges as a state-of-the-art instrument in the next funding period we will propose to upgrade IN12 with a multi-analyser option similar to planned or existing RITA-type instruments. IN12 will then be optionally equipped with an array of individual analyser blades which can be positioned separately in order to map the scattered beam on a user-chosen path in (Q,ω)-space. We refer to this set-up as IN12-UFO (universal focusing option). Both, the feasibility and the scientific case are currently being studied. On the conference we will show details of the planned instrumental set-up and demonstrate its flexibility and multiplex advantages for specific physical applications.

  12. UFO--a multi-analyser option for IN12

    International Nuclear Information System (INIS)

    Schmidt, Wolfgang; Rheinstaedter, Maikel C.; Raymond, Stephane; Ohl, Michael

    2004-01-01

    The IN12 instrument is operated by FZ Juelich in collaboration with CEA Grenoble as a CRG-B instrument at the Institut Laue Langevin in Grenoble. As a three-axis spectrometer for cold neutrons it is dedicated for high-resolution studies of low-energy excitations. In the past years the instrument has been continuously improved and it has demonstrated its excellent performance for neutron scattering research. To meet further challenges as a state-of-the-art instrument in the next funding period we will propose to upgrade IN12 with a multi-analyser option similar to planned or existing RITA-type instruments. IN12 will then be optionally equipped with an array of individual analyser blades which can be positioned separately in order to map the scattered beam on a user-chosen path in (Q,ω)-space. We refer to this set-up as IN12-UFO (universal focusing option). Both, the feasibility and the scientific case are currently being studied. On the conference we will show details of the planned instrumental set-up and demonstrate its flexibility and multiplex advantages for specific physical applications

  13. Geophysical variables and behavior: XXIII. Relations between UFO reports within the Uinta Basin and local seismicity.

    Science.gov (United States)

    Persinger, M A; Derr, J S

    1985-02-01

    A strong temporal correlation was found between the numbers of reports of UFOs (unidentified flying objects) and nearby seismic activity within the Uinta Basin for the year 1967. The numbers of UFO reports per month during this classic UFO flap were correlated 0.80 with the sum of the earthquake magnitudes per month for events within 150 km of the report area. Numbers of UFO reports were not correlated significantly with earthquake activity at distances greater than 150 km but less than 250 km away. The strongest correlation occurred between UFO reports and nearby seismic activity within the same month but not for previous or consequent months. Close scrutiny of daily shifts in epicenters and reports of UFOs indicate that they occurred when the locus of successive epicenters shifted across the area. These analyses were interpreted as support for the existence of strain fields whose movements generate natural phenomena that are reported as UFOs.

  14. Unidentified Flying Objects (UFOs). LC Science Tracer Bullet.

    Science.gov (United States)

    Library of Congress, Washington, DC. Science and Technology Div.

    This guide lists information sources dealing with unidentified flying objects (UFOs). Not meant to be a comprehensive bibliography, this compilation is designed--as the name of the series implies--to put the reader "on target." Included are: (1) subject headings used by the Library of Congress, under which publications on this subject…

  15. Imprecision and Uncertainty in the UFO Database Model.

    Science.gov (United States)

    Van Gyseghem, Nancy; De Caluwe, Rita

    1998-01-01

    Discusses how imprecision and uncertainty are dealt with in the UFO (Uncertainty and Fuzziness in an Object-oriented) database model. Such information is expressed by means of possibility distributions, and modeled by means of the proposed concept of "role objects." The role objects model uncertain, tentative information about objects,…

  16. Study on Ca2+ antagonistic effect and mechanism of Chinese herbal drugs using 45Ca

    International Nuclear Information System (INIS)

    Yang Yuanyou; Liu Ning; Mo Shangwu; Qiu Mingfeng; Jin Jiannan; Liao Jiali

    2002-01-01

    The Ca 2+ antagonistic effect and mechanism of Chinese herbal drugs are studied by using 45 Ca. The results indicate that potential-dependent Ca 2+ channel (PDC) and receptor-operated Ca 2+ channel (ROC) in cell membranes of smooth muscle can be blocked by several Chinese herbal drugs, including as Crocus sativus L., Carthamus L., Di-ao-xin-xue-kang (DAXXG) and Ginkgo biloba L. leaves. Among them Crocus sativus L. has the strongest antagonistic effect on Ca 2+ channel, while Ginkgo biloba L. leaves has no obvious effect. The whole prescription and the other functional drugs have significant effect on ROC and PDC. The compositions extracted by hexane have the strongest antagonistic. The wrinkled giant hyssop have five active compositions and Pei-lan have two active compositions

  17. Investigation of UFO defect on DUV CAR and BARC process

    Science.gov (United States)

    Yet, Siew Ing; Ko, Bong Sang; Lee, Soo Man; May, Mike

    2004-05-01

    Photo process defect reduction is one of the most important factors to improve the process stability and yield in sub-0.18um DUV process. In this paper, a new approach to minimize the Deep-UV (DUV) Chemically Amplified Resist (CAR) and Bottom Anti-Reflective Coating (BARC) induced defect known as UFO (UnidentiFied Object) defect will be introduced. These defects have mild surface topography difference on BARC; it only exists on the wide exposed area where there is no photoresist pattern. In this test, Nikon KrF Stepper & Scanner and TEL Clean track were used. Investigation was carried out on the defect formulation on both Acetal and ESCAP type of photoresist while elemental analysis was done by Atomic Force Microscope (AFM) & Auger Electron Spectroscopy (AES). Result indicated that both BARC and photoresist induce this UFO defect; total defect quantity is related with Post Exposure Bake (PEB) condition. Based on the elemental analysis and process-split test, we can conclude that this defect is caused by lack of acid amount and low diffusivity which is related to PAG (Photo Acid Generator) and TAG (Thermal Acid Generator) in KrF photoresist and BARC material. By optimizing photoresist bake condition, this UFO defect as well as other related defect such as Satellite defect could be eliminated.

  18. Interlaboratory study for coral Sr/Ca and other element/Ca ratio measurements

    OpenAIRE

    Hathorne, Ed C.; Gagnon, Alex; Felis, Thomas; Adkins, Jess; Asami, Ryuji; Boer, Wim; Caillon, Nicolas; Case, David; Cobb, Kim M.; Douville, Eric; deMenocal, Peter; Eisenhauer, Anton; Garbe-Schönberg, Dieter; Geibert, Walter; Goldstein, Steven L.

    2013-01-01

    The Sr/Ca ratio of coral aragonite is used to reconstruct past sea surface temperature (SST). Twenty-one laboratories took part in an interlaboratory study of coral Sr/Ca measurements. Results show interlaboratory bias can be significant, and in the extreme case could result in a range in SST estimates of 7 degrees C. However, most of the data fall within a narrower range and the Porites coral reference material JCp-1 is now characterized well enough to have a certified Sr/Ca value of 8.838 m...

  19. How the Elderly Can Use Scientific Knowledge to Solve Problems While Designing Toys: A Retrospective Analysis of the Design of a Working UFO

    Science.gov (United States)

    Chen, Mei-Yung; Hong, Jon-Chao; Hwang, Ming-Yueh; Wong, Wan-Tzu

    2013-01-01

    The venerable aphorism "an old dog cannot learn new tricks" implies that the elderly rarely learn anything new--in particular, scientific knowledge. On the basis of "learning by doing," the present study emphasized knowledge application (KA) as elderly subjects collaborated on the design of a toy flying saucer (UFO). Three…

  20. Kinetic studies of calcium in human by 41Ca tracing

    International Nuclear Information System (INIS)

    Boaretto, E.; Paul, M.; Gelbart, Z.; Johnson, R.R.; Meirav, O.; Sossi, V.; Venczel, E.; Hollos, G.; Prior, J.

    1992-01-01

    41 Ca (T 1/2 = 1 x 10 5 years) is an ideal tracer for long-term studies of calcium kinetics in biological systems for several reasons: (a) it behaves as a stable nuclide for all practical purpose due to its very long radioactive half-life; (b) its natural abundance is extremely low; (c) 41 Ca isotopic concentrations can now be measured to very high sensitivity by accelerator mass spectrometry, requiring therefore injection doses with no collateral radiation effects. Such an experiment has been initiated in a human subject by intravenous injection of a 126 ng dose of 41 Ca on July 18, 1990. The 41 Ca concentration and the 41 Ca/Ca isotopic ratios in serum and urine have been measured at five times over a 270 days period, showing a decrease in agreement with known time constants of the different calcium pools. It is planned to follow up the steady-state 41 Ca level ( 41 Ca/Ca ∼9 x 10 -12 ) over time (e.g. menstrual cycle, age)

  1. The murine ufo receptor: molecular cloning, chromosomal localization and in situ expression analysis.

    Science.gov (United States)

    Faust, M; Ebensperger, C; Schulz, A S; Schleithoff, L; Hameister, H; Bartram, C R; Janssen, J W

    1992-07-01

    We have cloned the mouse homologue of the ufo oncogene. It encodes a novel tyrosine kinase receptor characterized by a unique extracellular domain containing two immunoglobulin-like and two fibronectin type III repeats. Comparison of the predicted ufo amino acid sequences of mouse and man revealed an overall identity of 87.6%. The ufo locus maps to mouse chromosome 7A3-B1 and thereby extends the known conserved linkage group between mouse chromosome 7 and human chromosome 19. RNA in situ hybridization analysis established the onset of specific ufo expression in the late embryogenesis at day 12.5 post coitum (p.c.) and localized ufo transcription to distinct substructures of a broad spectrum of developing tissues (e.g. subepidermal cells of the skin, mesenchymal cells of the periosteum). In adult animals ufo is expressed in cells forming organ capsules as well as in connective tissue structures. ufo may function as a signal transducer between specific cell types of mesodermal origin.

  2. AGN feedback through UFO and galaxy-wide winds in the early Universe

    Science.gov (United States)

    Feruglio, C.; Piconcelli, E.; Bischetti, M.; Zappacosta, L.; Fiore, F.

    2017-10-01

    AGN feedback through massive molecular winds is today routinely observed in local AGN host galaxies, but not as such in the early universe. I will present the first evidence for a massive, AGN-driven molecular wind in the z 4 QSO APM08279, which also hosts the most well studied and persistent nuclear semi-raltivistic wind (UFO). This observation directly probes the expansion mechanism of a nuclear wind into the ISM on galaxy wide scales, that so far was constrained by a couple of other objects only (Feruglio et al. 2015, Tombesi et al. 2015). This result also opens the path toward the exploration of molecular AGN-driven winds at early epochs, close after the end of the Epoch of Reionisation (EoR).

  3. Study of 51Ca via three-neutron transfer

    International Nuclear Information System (INIS)

    Catford, W.N.; Fifield, L.K.; Ophel, T.R.; Orr, N.A.; Weisser, D.C.; Woods, C.L.

    1988-09-01

    Low-lying levels in 51 Ca have been studied via the reaction 48 Ca( 18 O, 15 O) 51 Ca at a beam energy of 108 MeV. Recoiling 51 Ca nuclei were detected in coincidence with 15 O ejectiles, largely removing the substantial background from target contaminants that was encountered in previous work. The lowest 51C a level identified is 1.01 ± 0.11 MeV less bound than the ground state, according to a recent measurement of the ground state mass using the 48 Ca( 14 C, 11 C) 51 Ca reaction. Considerations of the difficulty in identifying the ground state peak suggest that published values of the mass excess should be viewed with caution, and that a definitive mass measurement is still required in order to resolve questions on the structure of the neutron rich calcium isotopes. A total of six energy levels in 51 Ca have been identified and their mass excesses measured. Only two of these levels have been observed previously, via the ( 14 C, 11 C) reaction. Striking differences in selectivity between the ( 18 O, 15 O) and ( 14 C, 11 C) transfer reactions are discussed

  4. Algorithms for the automatic identification of MARFEs and UFOs in JET database of visible camera videos

    International Nuclear Information System (INIS)

    Murari, A.; Camplani, M.; Cannas, B.; Usai, P.; Mazon, D.; Delaunay, F.

    2010-01-01

    MARFE instabilities and UFOs leave clear signatures in JET fast visible camera videos. Given the potential harmful consequences of these events, particularly as triggers of disruptions, it would be important to have the means of detecting them automatically. In this paper, the results of various algorithms to identify automatically the MARFEs and UFOs in JET visible videos are reported. The objective is to retrieve the videos, which have captured these events, exploring the whole JET database of images, as a preliminary step to the development of real-time identifiers in the future. For the detection of MARFEs, a complete identifier has been finalized, using morphological operators and Hu moments. The final algorithm manages to identify the videos with MARFEs with a success rate exceeding 80%. Due to the lack of a complete statistics of examples, the UFO identifier is less developed, but a preliminary code can detect UFOs quite reliably. (authors)

  5. Ultra-fast outflows (aka UFOs) in AGNs and their relevance for feedback

    Science.gov (United States)

    Cappi, Massimo; Tombesi, F.; Giustini, M.; Dadina, M.; Braito, V.; Kaastra, J.; Reeves, J.; Chartas, G.; Gaspari, M.; Vignali, C.; Gofford, J.; Lanzuisi, G.

    2012-09-01

    During the last decade, several observational evidences have been accumulated for the existence of massive, high velocity winds/outflows (aka UFOs) in nearby AGNs and, possibly, distant quasars. I will review here such evidences, present some of the latest results in this field, and discuss the relevance of UFOs for both understanding the physics of accretion/ejection flows on supermassive black holes, and for quantifying the amount of AGN feedback.

  6. Vibrational spectroscopic study of poldervaartite CaCa[SiO3(OH)(OH)

    Science.gov (United States)

    Frost, Ray L.; López, Andrés; Scholz, Ricardo; Lima, Rosa Malena Fernandes

    2015-02-01

    We have studied the mineral poldervaartite CaCa[SiO3(OH)(OH)] which forms a series with its manganese analogue olmiite CaMn[SiO3(OH)](OH) using a range of techniques including scanning electron microscopy, thermogravimetric analysis, Raman and infrared spectroscopy. Chemical analysis shows the mineral is reasonably pure and contains only calcium and manganese with low amounts of Al and F. Thermogravimetric analysis proves the mineral decomposes at 485 °C with a mass loss of 7.6% compared with the theoretical mass loss of 7.7%. A strong Raman band at 852 cm-1 is assigned to the SiO stretching vibration of the SiO3(OH) units. Two Raman bands at 914 and 953 cm-1 are attributed to the antisymmetric vibrations. Intense prominent peaks observed at 3487, 3502, 3509, 3521 and 3547 cm-1 are assigned to the OH stretching vibration of the SiO3(OH) units. The observation of multiple OH bands supports the concept of the non-equivalence of the OH units. Vibrational spectroscopy enables a detailed assessment of the molecular structure of poldervaartite.

  7. Structural, dielectric and piezoelectric study of Ca-, Zr-modified ...

    Indian Academy of Sciences (India)

    2017-08-22

    Aug 22, 2017 ... Structural, dielectric and piezoelectric study of Ca-, Zr-modified. BaTiO3 lead-free ceramics ... small amounts of Zr4+ can affect the crystal structure and microstructure as well as dielectric and piezoelectric properties of BaTiO3. ..... We would like to thank PHC Toubkal for the financial support. References.

  8. Differential expression of the ufo/axl oncogene in human leukemia-lymphoma cell lines.

    Science.gov (United States)

    Challier, C; Uphoff, C C; Janssen, J W; Drexler, H G

    1996-05-01

    The ufo protein (also termed axl) is a member of a new family of receptor tyrosine kinases and is encoded by a transforming gene that was initially isolated from primary human myeloid leukemia cells by DNA-mediated transformation of NIH/3T3 cells. The ligand, Gas6, a protein S-related molecule lacking any known function yet, has recently been identified. We report the expression pattern of ufo mRNA in a panel of 76 human continuous leukemia-lymphoma cell lines. The gene was not expressed in cell lines derived from lymphoid malignancies (n=28), but transcription was seen in 3/11 myeloid, 0/6 monocytic, 9/13 erythroid and 11/18 megakaryocytic cell lines. Several cell lines were treated with phorbol ester leading to significant upregulation of the ufo message in constitutively positive cells. An apparent ufo mRNA overexpression was not found in any of the positive leukemia cell lines, but was identified in the drug-resistant subclones of the cervix carcinoma cell line HeLa. Southern blot analysis of restriction enzyme-digested genomic DNA did not provide evidence for gene amplification, but the HeLa subclones showed banding patterns suggestive of gene rearrangement. Two main ufo mRNA bands of 3.2 and 5.0 kb were identified; no differences in the half-lives (t1/2 = 2.5 h) of these two mRNA species could be identified. In summary, ufo, representing a novel type of receptor tyrosine kinase, is expressed solely in myeloid and erythro-megakaryocytic leukemias but not in lymphoid malignancies. These and previous data suggest an involvement of the ufo receptor tyrosine kinase in normal and malignant myelopoiesis; however, its exact role, if any, and mode of operation in leukemogenesis remains to be determined.

  9. UFO in the Arabidopsis inflorescence apex is required for floral-meristem identity and bract suppression.

    Science.gov (United States)

    Hepworth, Shelley R; Klenz, Jennifer E; Haughn, George W

    2006-03-01

    The UNUSUAL FLORAL ORGANS (UFO) gene of Arabidopsis encodes an F-box protein required for the determination of floral-organ and floral-meristem identity. Mutation of UFO leads to dramatic changes in floral-organ type which are well-characterized whereas inflorescence defects are more subtle and less understood. These defects include an increase in the number of secondary inflorescences, nodes that alternate between forming flowers and secondary inflorescences, and nodes in which a single flower is subtended by a bract. Here, we show how inflorescence defects correlate with the abnormal development of floral primordia and establish a temporal requirement for UFO in this process. At the inflorescence apex of ufo mutants, newly formed primordia are initially bract-like. Expression of the floral-meristem identity genes LFY and AP1 are confined to a relatively small adaxial region of these primordia with expression of the bract-identity marker FIL observed in cells that comprise the balance of the primordia. Proliferation of cells in the adaxial region of these early primordia is delayed by several nodes such that primordia appear "chimeric" at several nodes, having visible floral and bract components. However, by late stage 2 of floral development, growth of the bract generally ceases and is overtaken by development of the floral primordium. This abnormal pattern of floral meristem development is not rescued by expression of UFO from the AP1 promoter, indicating that UFO is required prior to AP1 activation for normal development of floral primordia. We propose that UFO and LFY are jointly required in the inflorescence meristem to both promote floral meristem development and inhibit, in a non-cell autonomous manner, growth of the bract.

  10. Study of giant multipole resonances in 40Ca

    International Nuclear Information System (INIS)

    Rost, H.

    1979-01-01

    In the present thesis giant resonance states in 40 Ca were studied by scattering of 104 MeV a particles on 40 Ca and by the reactions 39 K(p vector,p') 39 K and 39 K(p,α) 36 Ar. The scattered α-particles were measured at extreme forward angles (THETAsub(L) = 4 0 -16 0 C), because at forward angles the cross sections for the excitation of states with spin 0 and 1 strongly differ from those with higher spin. The aim of this experiment was first of all the study of the giant resonance region in 40 Ca on the contribution to 0 + or 1 - states. Beside the known electric giant quadrupole resonances at Esub(x) approx. equal to 18.5 MeV (25% EWSR) contributions of EO-strength at Esub(x) approx. equal to 21 MeV (6% EWSR) and indications to a (isoscalar) E1-strength at Esub(x) approx. equal to 14 MeV and Esub(x) approx. equal to 16 MeV were found. At the reactions 39 K(p vector,p') 39 K and 39 K(p,α) 36 Ar in the channels (p,p 0 ),(p,p 4 ), (p,αsub(o)), and (p,α 1 ) at incident energies at about 10 MeV (Esub(x)( 40 Ca) approx. equal to 18 MeV) resonant structures were observed. A scattering phase analysis performed for the elastic proton scattering didn't however yield quantitative results about the resonance parameter. An expansion of the cross sections by Legendre polynomials for the remaining reaction channel didn't allow a conclusion about the dominance of a certain L-value. The only indication to the connection of the observed resonant structures with the giant quadrupole resonance in 40 Ca is therefore the energetic position at about Esub(x) approx. equal to 18 MeV. Altogether the observed structures however were not very pronounced, so it can be concluded, that the excitation of the giant quadrupole resonance in 40 Ca by protons via the ground state of 39 K occurs not very strongly. (orig./HSI) [de

  11. Comparative study of structural, electronic and optical properties of Ca2Si, Ca2Ge, Ca2Sn, and Ca2Pb

    Science.gov (United States)

    Migas, D. B.; Miglio, Leo; Shaposhnikov, V. L.; Borisenko, V. E.

    2003-05-01

    We report ab initio results for the ground-state properties, band diagrams, density of states, and dielectric functions of Ca2Z (Z=Si, Ge, Sn, and Pb) both in the orthorhombic and cubic structures. The calculations are performed by means of total energy ultrasoft pseudopotential and full potential linearized augmented plane wave methods within local density and generalized gradient approximations. The estimated difference in the cohesion energy shows the orthorhombic structure to be the stable phase. We also demonstrate that these materials are semiconductors independently of the phase. A direct energy gap and sizable anisotropy in optical spectra characterize orthorhombic Ca2Z, whereas a competitive direct-indirect character of the gap and a high value of oscillator strength of the first direct transition are predicted for cubic Ca2Z.

  12. Studies of highly ionized atoms using internal conversion: 197Au, 57Fe; electric monopole transitions in 40Ca, 42Ca, and 44Ca

    International Nuclear Information System (INIS)

    Ulrickson, M.A.

    1975-01-01

    By using heavy-ion reactions, highly ionized electronic states of atoms may be produced. The interaction between excited nuclear levels and the surrounding atomic electrons via internal conversion allows the nucleus to be used as a probe of the electronic structure of the highly ionized atoms. Studies of such atoms were undertaken for strongly internally converted nuclear levels in 197 Au and 57 Fe. The nuclear levels were Coulomb excited by using 16 O and 32 S beams. Simultaneous measurement of the lifetime of the 77-keV state of 197 Au in both neutral gold atoms and gold atoms with mean charge +10 resulted in a measured change in the internal conversion coefficient of Δalpha/alpha equals - 1.7 +- 3.0)10 -3 . This result is consistent with calculations using a Hartree-Fock--Slater program. Measurements of the electric monopole strengths for 0 + → 0 + transitions were undertaken to determine the amount of core-deformation in calcium nuclei. The E0 strengths for the decays of the 0 + states at 5.21 MeV in 40 C, 1.84 MeV in 42 Ca, and 1.88 MeV in 44 Ca were observed. The branching ratios for the subsequent E0 pair decays were measured by observing the coincident annihilation radiation from the e + member of the pair in coincidence with protons feeding the state in the cases of 42 Ca and 44 Ca, and by observing the actual coincident e + --e - pair together with protons feeding the state in the case of 40 Ca. The resulting E0 strengths (rho less than or equal to 0.06, rho = 0.34 +- 0.03, rho = 0.30 +- 0.10 for 40 Ca, 42 Ca, and 44 Ca respectively) agree with theoretical descriptions

  13. UNIFORM FARM OPERATIONS (UFO ON HEMP BROOM RAPE SEED GERMINATION BY BIOLOGICAL CONTROL MANAGEMENT IN IRAN

    Directory of Open Access Journals (Sweden)

    Behzad SANI

    2014-06-01

    Full Text Available Weeds are a constant problem in agronomy and they not only compete with crops for water, nutrients, sunlight, andspace but also harbor insect and disease pests; clog irrigation and drainage systems; undermine crop quality; anddeposit weed seeds into crop harvests. In order to the microbial herbicide (Orocide influence on seed germinationin Orobancheramosa L., this experiment was conducted in 2011 at Islamic Azad University Shahr-e-Qods Branch inTehran by a completely randomized design with four replications. The factor studied included use of Orocide(0(T1, 2(T2, 4(T3 and 6(T4 percentage. The results showed that the effect of microbial herbicide (Orocide wassignificant on germination percentage of Orobancheramosa. Mean comparison showed that the highest germinationpercentage (79% was achieved by non-application of Orocide and lowest germination percentage (8% wasachieved by application of 4% Orocide.The results of this experiment showed that the use of Orocide can decreasedthe germination in Orobancheramosa L. that is uniform farm operations (UFO very important for weed biologicalcontrol management at Iran.

  14. The F-box-containing protein UFO and AGAMOUS participate in antagonistic pathways governing early petal development in Arabidopsis.

    Science.gov (United States)

    Durfee, Tim; Roe, Judith L; Sessions, R Allen; Inouye, Carla; Serikawa, Kyle; Feldmann, Kenneth A; Weigel, Detlef; Zambryski, Patricia C

    2003-07-08

    The UNUSUAL FLORAL ORGANS (UFO) gene is required for multiple processes in the developing Arabidopsis flower, including the proper patterning and identity of both petals and stamens. The gene encodes an F-box-containing protein, UFO, which interacts physically and genetically with the Skp1 homolog, ASK1. In this report, we describe four ufo alleles characterized by the absence of petals, which uncover another role for UFO in promoting second whorl development. This UFO-dependent pathway is required regardless of the second whorl organ to be formed, arguing that it affects a basic process acting in parallel with those establishing organ identity. However, the pathway is dispensable in the absence of AGAMOUS (AG), a known inhibitor of petal development. In situ hybridization results argue that AG is not transcribed in the petal region, suggesting that it acts non-cell-autonomously to inhibit second whorl development in ufo mutants. These results are combined into a genetic model explaining early second whorl initiation/proliferation, in which UFO functions to inhibit an AG-dependent activity.

  15. The COP9 signalosome interacts with SCF UFO and participates in Arabidopsis flower development.

    Science.gov (United States)

    Wang, Xiping; Feng, Suhua; Nakayama, Naomi; Crosby, W L; Irish, Vivian; Deng, Xing Wang; Wei, Ning

    2003-05-01

    The COP9 signalosome (CSN) is involved in multiple developmental processes. It interacts with SCF ubiquitin ligases and deconjugates Nedd8/Rub1 from cullins (deneddylation). CSN is highly expressed in Arabidopsis floral tissues. To investigate the role of CSN in flower development, we examined the expression pattern of CSN in developing flowers. We report here that two csn1 partially deficient Arabidopsis strains exhibit aberrant development of floral organs, decline of APETALA3 (AP3) expression, and low fertility in addition to defects in shoot and inflorescence meristems. We show that UNUSUAL FLORAL ORGANS (UFO) forms a SCF(UFO) complex, which is associated with CSN in vivo. Genetic interaction analysis indicates that CSN is necessary for the gain-of-function activity of the F-box protein UFO in AP3 activation and in floral organ transformation. Compared with the previously reported csn5 antisense and csn1 null mutants, partial deficiency of CSN1 causes a reduction in the level of CUL1 in the mutant flowers without an obvious defect in CUL1 deneddylation. We conclude that CSN is an essential regulator of Arabidopsis flower development and suggest that CSN regulates Arabidopsis flower development in part by modulating SCF(UFO)-mediated AP3 activation.

  16. Media Impact on Fright Reactions and Belief in UFOs: The Potential Role of Mental Imagery.

    Science.gov (United States)

    Sparks, Glenn G.; And Others

    1995-01-01

    Explores the potential role of mental imagery for media effects in emotional responses to frightening mass media, and in the effects of the media on beliefs in UFOs. Finds that individual differences in vividness of mental imagery may play a crucial role in moderating both types of media impact. (SR)

  17. Higher risk of incident hepatitis C virus among young women who inject drugs compared with young men in association with sexual relationships: a prospective analysis from the UFO Study cohort.

    Science.gov (United States)

    Tracy, Daniel; Hahn, Judith A; Fuller Lewis, Crystal; Evans, Jennifer; Briceño, Alya; Morris, Meghan D; Lum, Paula J; Page, Kimberly

    2014-05-29

    Female injection drug users (IDUs) may report differences in injection behaviours that put them at greater risk for hepatitis C virus (HCV). Few studies have examined these in association with HCV incidence. Longitudinal data from a cohort of 417 HCV-uninfected IDU aged 30 or younger were analysed. Cox proportional hazards was used to model female sex as a predictor of new HCV infection. General estimating equation (GEE) analysis was used to model female sex as a predictor of HCV-associated risk behaviour prospectively. Women were significantly more likely than men to become infected with HCV during study follow-up (HR 1.4, p<0.05), and were also more likely than men to report high-risk injecting behaviours, especially in the context of sexual and injecting relationships. Sex differences in injecting behaviours appeared to explain the relationship between sex and HCV infection. Young women's riskier injection practices lead to their higher rates of HCV infection. Further study on the impact of intimate partnership on women's risk behaviour is warranted. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  18. Structural studies of Ca2+-ATPase ligand and regulatory complexes

    DEFF Research Database (Denmark)

    Drachmann, Nikolaj Düring

    2015-01-01

    , the surrounding membrane itself has a huge influence on SERCA structure and function. Changes in the membrane thickness can alter the activity of the ATPase significantly, and even cause changes in the stoichiometry of ion transport. Structural studies on SERCA in the presence of four different phosphatidyl...... choline lipids with different aliphatic chain length and saturation show three specific lipid binding sites. The four different lipids analysed bind to the same binding sites with varying degrees of disorder. The study contributes to understanding the complex interplay between the surrounding membrane...... to explore the possibilities for an efficient screening of ligand-bound SERCA structures, serial femtosecond crystallography experiments of microcrystals of SERCA1a in the Ca2+ bound state and in a vanadate stabilised E2 state was conducted. A structure obtained at 2.8 Å maximum resolution of the proof...

  19. IN12-UFO: new frontiers for cold triple-axis spectroscopy

    International Nuclear Information System (INIS)

    Schmidt, Wolfgang; Ohl, Michael

    2006-01-01

    The IN12 instrument is operated by the Research Centre at Juelich in collaboration with CEA Grenoble as a CRG-B instrument at the Institute Laue Langevin in Grenoble. As a triple-axis spectrometer for cold neutrons it is dedicated for high-resolution studies of low-energy excitations. To meet further challenges as a state-of-the-art instrument we will now upgrade IN12 with a multi-analyzer option. IN12 will then be equipped with a large 2-dimensional position sensitive detector and an array of 15 individual analyser blades which can be rotated and positioned separately in order to map the scattered beam on a user-chosen path in Q-ω-space. We refer to this set-up as IN12-UFO (Universal Focusing Option). The innovative flexibility of the analyzer array is realized by completely non-magnetic drive mechanisms where all relevant parameters are controlled by an absolute encoding system. This mechanics allows to position the individual analyzers so that (a) there are no gaps or overlaps as seen from the sample (optimum coverage) and (b) all reflected beams from the analyzers meet at one single focus point on their way to different spots on the detector surface. The focus point is controlled by a movable diaphragm and provides the only opening between analyzer and detector shielding to prevent cross-talk and to keep the background low. We will present further details of this set-up and demonstrate its flexibility and multiplex advantages for specific physical applications

  20. IN12-UFO: new frontiers for cold triple-axis spectroscopy

    Science.gov (United States)

    Schmidt, Wolfgang; Ohl, Michael

    2006-11-01

    The IN12 instrument is operated by the Research Centre at Jülich in collaboration with CEA Grenoble as a CRG-B instrument at the Institute Laue Langevin in Grenoble. As a triple-axis spectrometer for cold neutrons it is dedicated for high-resolution studies of low-energy excitations. To meet further challenges as a state-of-the-art instrument we will now upgrade IN12 with a multi-analyzer option. IN12 will then be equipped with a large 2-dimensional position sensitive detector and an array of 15 individual analyser blades which can be rotated and positioned separately in order to map the scattered beam on a user-chosen path in Q- ω-space. We refer to this set-up as IN12-UFO (Universal Focusing Option). The innovative flexibility of the analyzer array is realized by completely non-magnetic drive mechanisms where all relevant parameters are controlled by an absolute encoding system. This mechanics allows to position the individual analyzers so that (a) there are no gaps or overlaps as seen from the sample (optimum coverage) and (b) all reflected beams from the analyzers meet at one single focus point on their way to different spots on the detector surface. The focus point is controlled by a movable diaphragm and provides the only opening between analyzer and detector shielding to prevent cross-talk and to keep the background low. We will present further details of this set-up and demonstrate its flexibility and multiplex advantages for specific physical applications.

  1. A Discussion On A Physical Model Of Ball Lightning And UFO

    Directory of Open Access Journals (Sweden)

    Ivan L. Bajak

    2017-07-01

    Full Text Available It is proposed that the ball lightning and UFO are analogous objects. The variety of different observations is explained. It is proposed on a uniform basis using a hypothesis that the ball lightning and UFO are created like a spherical capacitor filled by polar molecules mainly and in some cases by various chemicals which influence the final manifest of the object. A mechanism of a formation of the spherical capacitor is discussed. A peculiar behavior like e.g. sudden change of direction of motion shape of disc and possible penetration through wall is explained as a consequence of internal structure of the object. Finally an experimental verification of the hypothesis is suggested.

  2. Mutation in Torenia fournieri Lind. UFO homolog confers loss of TfLFY interaction and results in a petal to sepal transformation.

    Science.gov (United States)

    Sasaki, Katsutomo; Yamaguchi, Hiroyasu; Aida, Ryutaro; Shikata, Masahito; Abe, Tomoko; Ohtsubo, Norihiro

    2012-09-01

    We identified a Torenia fournieri Lind. mutant (no. 252) that exhibited a sepaloid phenotype in which the second whorls were changed to sepal-like organs. This mutant had no stamens, and the floral organs consisted of sepals and carpels. Although the expression of a torenia class B MADS-box gene, GLOBOSA (TfGLO), was abolished in the 252 mutant, no mutation of TfGLO was found. Among torenia homologs such as APETALA1 (AP1), LEAFY (LFY), and UNUSUAL FLORAL ORGANS (UFO), which regulate expression of class B genes in Arabidopsis, only accumulation of the TfUFO transcript was diminished in the 252 mutant. Furthermore, a missense mutation was found in the coding region of the mutant TfUFO. Intact TfUFO complemented the mutant phenotype whereas mutated TfUFO did not; in addition, the transgenic phenotype of TfUFO-knockdown torenias coincided with the mutant phenotype. Yeast two-hybrid analysis revealed that the mutated TfUFO lost its ability to interact with TfLFY protein. In situ hybridization analysis indicated that the transcripts of TfUFO and TfLFY were partially accumulated in the same region. These results clearly demonstrate that the defect in TfUFO caused the sepaloid phenotype in the 252 mutant due to the loss of interaction with TfLFY. © 2012 The Authors. The Plant Journal © 2012 Blackwell Publishing Ltd.

  3. Asia prostate cancer study (A-CaP Study launch symposium

    Directory of Open Access Journals (Sweden)

    Hideyuki Akaza

    2016-09-01

    Full Text Available The Asian Prostate Cancer (A-CaP Study is an Asia-wide initiative that has been developed over the course of 2 years. The A-CaP Study is scheduled to begin in 2016, when each participating country or region will begin registration of newly diagnosed prostate cancer patients and conduct prognosis investigations. From the data gathered, common research themes will be identified, such as comparisons among Asian countries of background factors in newly diagnosed prostate cancer patients. This is the first Asia-wide study of prostate cancer and has developed from single country research efforts in this field, including in Japan and Korea. The inaugural Board Meeting of A-CaP was held on December 11, 2015 at the Research Center for Advanced Science and Technology, The University of Tokyo, attended by representatives of all participating countries and regions, who signed a memorandum of understanding concerning registration for A-CaP. Following the Board Meeting an A-CaP Launch Symposium was held. The symposium was attended by representatives of countries and regions participating in A-CaP, who gave presentations. Presentations and a keynote address were also delivered by representatives of the University of California San Francisco, USA, and the Peter MacCallum Cancer Centre, Australia, who provided insight and experience on similar databases compiled in their respective countries.

  4. UFO: a web server for ultra-fast functional profiling of whole genome protein sequences.

    Science.gov (United States)

    Meinicke, Peter

    2009-09-02

    Functional profiling is a key technique to characterize and compare the functional potential of entire genomes. The estimation of profiles according to an assignment of sequences to functional categories is a computationally expensive task because it requires the comparison of all protein sequences from a genome with a usually large database of annotated sequences or sequence families. Based on machine learning techniques for Pfam domain detection, the UFO web server for ultra-fast functional profiling allows researchers to process large protein sequence collections instantaneously. Besides the frequencies of Pfam and GO categories, the user also obtains the sequence specific assignments to Pfam domain families. In addition, a comparison with existing genomes provides dissimilarity scores with respect to 821 reference proteomes. Considering the underlying UFO domain detection, the results on 206 test genomes indicate a high sensitivity of the approach. In comparison with current state-of-the-art HMMs, the runtime measurements show a considerable speed up in the range of four orders of magnitude. For an average size prokaryotic genome, the computation of a functional profile together with its comparison typically requires about 10 seconds of processing time. For the first time the UFO web server makes it possible to get a quick overview on the functional inventory of newly sequenced organisms. The genome scale comparison with a large number of precomputed profiles allows a first guess about functionally related organisms. The service is freely available and does not require user registration or specification of a valid email address.

  5. UFOING: A program for assessing the off-site consequences from ingestion of accidentally released radionuclides

    International Nuclear Information System (INIS)

    Steinhauer, C.

    1988-12-01

    The program UFOING estimates foodchain-related consequences following accidental releases of radionuclides to the atmosphere. It was developed as a stand-alone supplement to the accident consequence assessment program system UFOMOD to allow faster and more detailed investigations of the consequences arising from the foodchain pathways than possible with the version of UFOING which is implemented in UFOMOD. For assumed releases at different times of the year, age dependent individual doses, collective doses, individual risks for fatal stochastic somatic health effects as a function of time, the total numbers of the effects, and the areas affected by foodbans together with the estimated duration of the bans are calculated. In addition, percentage contributions of radionuclides and foodstuffs to the doses and risks can be evaluated. In the first part of this report, an overview over the program is given. The other parts contain a user's guide, a program guide, and descriptions of the data employed and of the version of UFOING which is implemented in UFOMOD. (orig.) [de

  6. Structural studies of Ca2+-ATPase ligand and regulatory complexes

    DEFF Research Database (Denmark)

    Drachmann, Nikolaj Düring

    2015-01-01

    to explore the possibilities for an efficient screening of ligand-bound SERCA structures, serial femtosecond crystallography experiments of microcrystals of SERCA1a in the Ca2+ bound state and in a vanadate stabilised E2 state was conducted. A structure obtained at 2.8 Å maximum resolution of the proof......-of-concept Ca2+ bound crystal form, indicated that the information content of SFX data is higher than synchrotron data, and ligands and ions can be detected with low redundant data. The data of the E2 stabilised form was processed to 5 Å resolution, and it was possible to extract useful anomalous data showing...

  7. Mechanical and microstructure studies on the modification of CA film ...

    Indian Academy of Sciences (India)

    Unknown

    synthetic and biodegradable polymers will impart novel physical characteristics to the materials which can be ... most important organic ester of cellulose owing to its extensive applications in fibre, plastics and coatings. .... biodegradable material like CA, and a use and throw polymeric material so that the resultant product is ...

  8. The proton spectral function of 40Ca and 48Ca studied with the (e,e'p) reaction

    International Nuclear Information System (INIS)

    Kramer, G.J.

    1990-01-01

    This thesis presents the results of an experimental study into the occupation of the orbitals around the Fermi level for 40 Ca and 48 Ca with quasi-elastic proton knock-out (e,e'p). Experiments have been carried out with the 500 MeV electron beam of the linear accelerator MEA at NIKHEF, Amsterdam. For 40 Ca the mechanism of the (e,e'p) reaction has been studied by comparing the measured momentum distributions of some strong transitions to discrete states in 39K , with various theoretical calculations. From this it has been concluded that uncertainties caused by deviations of the impulse approximation can be minimized if the measurements are carried out under parallel kinematical conditions. The spectroscopic strengths of the shell-model orbitals in states just below the Fermi level, for 40 Ca the 1d 3/2 , 1d 5/2 and 2s 1/2 orbitals, turned out to amount 50 to 70% of the IPSM limit. A small part of the missing strength has been found in the 1f 7/2 and 2p 3/2 orbitals which are just above the Fermi level (resp. 11 and 2% of the 2j+1 limit), which is an indication for ground state correlations. The spectroscopic strengths for the 1d 3/2 , 2s 1/2 and 1d 3/2 orbitals of 48 Ca turned out to be the same as for 40C a within the actual measuring accuracy. Above the Fermi level only strength in the 1f 7/2 orbital has been found (1% of the 2j+1 limit). The spectroscopic strengths determined with (e,e'p) experiments are about a factor two smaller than those obtained from (d, 3 He) experiments. This discrepancy has been studied by reviewing the model dependency of the DWBA analysis for the (d, 3 He) reaction with special emphasis on the sensitivities of the spectroscopic factors to the various approximations made in this theory. It is also investigated which part of the bound state wave function is probed by the (e,e'p) and the (d, 3 He) reactions in order to understand the model sensitivities arising from the exact shape of the bound state wave function. (H.W.).97 refs.; 48

  9. Hydration and dehydration of CaO / Ca(OH){sub 2} and CaCl{sub 2} / CaCl{sub 2} * 6 H{sub 2}O-TGA / DSC studies

    Energy Technology Data Exchange (ETDEWEB)

    Rammelberg, Holger U.; Opel, O.; Ross, S.; Ruck, W. [Leuphana Univ., Lueneburg (Germany). Inst. of Environmental Chemistry

    2011-07-01

    Thermal energy storage drives the change towards the use of renewable energy resources and energy efficiency. The1mal storage can be used for waste heat and solar thermal usage. Solar thermal systems work at temperatures between 120 C (space heating and hot tap water) and up to 600 C (CSP plants), where thermal energy storage is a key component. In comparison to most commonly used water or molten salt storage, thermochemical storage materials provide ten times or higher storage capacities per mass or volume and the ability to store heat for longer times without the need of insulation. Recently published results state MgCl{sub 2} * 6 H{sub 2}O and CaCl{sub 2} * 6 H{sub 2}O to be useful for space heating and hot tap water and Ca(OH){sub 2} for higher temperature levels. We reported earlier about our studies in MgCl{sub 2} * 6 H{sub 2}O as pure and composite materials. In this paper we discuss the cycling stability of CaCl{sub 2} * 6 H{sub 2}O and Ca(OH){sub 2}.

  10. UFO: a web server for ultra-fast functional profiling of whole genome protein sequences

    Directory of Open Access Journals (Sweden)

    Meinicke Peter

    2009-09-01

    Full Text Available Abstract Background Functional profiling is a key technique to characterize and compare the functional potential of entire genomes. The estimation of profiles according to an assignment of sequences to functional categories is a computationally expensive task because it requires the comparison of all protein sequences from a genome with a usually large database of annotated sequences or sequence families. Description Based on machine learning techniques for Pfam domain detection, the UFO web server for ultra-fast functional profiling allows researchers to process large protein sequence collections instantaneously. Besides the frequencies of Pfam and GO categories, the user also obtains the sequence specific assignments to Pfam domain families. In addition, a comparison with existing genomes provides dissimilarity scores with respect to 821 reference proteomes. Considering the underlying UFO domain detection, the results on 206 test genomes indicate a high sensitivity of the approach. In comparison with current state-of-the-art HMMs, the runtime measurements show a considerable speed up in the range of four orders of magnitude. For an average size prokaryotic genome, the computation of a functional profile together with its comparison typically requires about 10 seconds of processing time. Conclusion For the first time the UFO web server makes it possible to get a quick overview on the functional inventory of newly sequenced organisms. The genome scale comparison with a large number of precomputed profiles allows a first guess about functionally related organisms. The service is freely available and does not require user registration or specification of a valid email address.

  11. Comparative Study of Electronic Structure and Magnetic Properties of Osmate Double Perovskites: Ca2FeOsO6 versus Ca2Co(Ni)OsO6

    Science.gov (United States)

    Samanta, Kartik; Saha-Dasgupta, Tanusri

    2018-04-01

    Employing density functional theory, we study the trend in the electronic and magnetic properties of 3d-5d double perovskites, upon varying the 3d element for a fixed choice of 5d element, namely Ca2BOsO6 (B = Fe/Co/Ni). While all three compounds are reported to be ferrimagnets, the magnetic transition temperature of Ca2FeOsO6 is reported to be 2-2.4 times larger than that of Ca2CoOsO6 or Ca2NiOsO6. Our first-principles study provides microscopic insight into this trend. This trend is found to be caused by the downward shift in the position of d level energies of the B site element with respect to that of the Os t2g level upon moving across the 3d series from Fe to Co and Ni. This in turn changes the nominal valence of the Os ion from 5+ in Ca2FeOsO6 to 6+ in Ca2CoOsO6 and Ca2NiOsO6, resulting in differing superexchange paths between Ca2FeOsO6 and Ca2Co(Ni)OsO6, and additionally enabling the hybridization-mechanism-driven magnetism in Ca2FeOsO6. These together significantly enhance the magnetic transition temperature in Ca2FeOsO6 compared with that in Ca2Co(Ni)OsO6.

  12. Ca2+/calmodulin-dependent kinase II-dependent regulation of atrial myocyte late Na+current, Ca2+cycling, and excitability: a mathematical modeling study.

    Science.gov (United States)

    Onal, Birce; Gratz, Daniel; Hund, Thomas J

    2017-12-01

    Atrial fibrillation (AF) affects more than three million people per year in the United States and is associated with high morbidity and mortality. Both electrical and structural remodeling contribute to AF, but the molecular pathways underlying AF pathogenesis are not well understood. Recently, a role for Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) in the regulation of persistent "late" Na + current ( I Na,L ) has been identified. Although I Na,L inhibition is emerging as a potential antiarrhythmic strategy in patients with AF, little is known about the mechanism linking I Na,L to atrial arrhythmogenesis. A computational approach was used to test the hypothesis that increased CaMKII-activated I Na,L in atrial myocytes disrupts Ca 2+ homeostasis, promoting arrhythmogenic afterdepolarizations. Dynamic CaMKII activity and regulation of multiple downstream targets [ I Na,L , L-type Ca 2+ current, phospholamban, and the ryanodine receptor sarcoplasmic reticulum Ca 2+ -release channel (RyR2)] were incorporated into an existing well-validated computational model of the human atrial action potential. Model simulations showed that constitutive CaMKII-dependent phosphorylation of Na v 1.5 and the subsequent increase in I Na,L effectively disrupt intracellular atrial myocyte ion homeostasis and CaMKII signaling. Specifically, increased I Na,L promotes intracellular Ca 2+ overload via forward-mode Na + /Ca 2+ exchange activity, which greatly increases RyR2 open probability beyond that observed for CaMKII-dependent phosphorylation of RyR2 alone. Increased I Na,L promotes atrial myocyte repolarization defects (afterdepolarizations and alternans) in the setting of acute β-adrenergic stimulation. We anticipate that our modeling efforts will help identify new mechanisms for atrial Na V 1.5 regulation with direct relevance for human AF. NEW & NOTEWORTHY Here, we present a novel computational model to study the effects of late Na + current ( I Na,L ) in human atrial

  13. Geophysical variables and behavior: XXVI. A response to Rutkowski's critique of the tectonic strain hypothesis for UFO phenomena.

    Science.gov (United States)

    Persinger, M A

    1985-04-01

    The tectonic strain hypothesis for many reports of UFOs (UFORs), primarily odd luminosities and metallic-looking phenomena, has been criticized on the basis of inadequate data. This reply begins with the distinction between the empirical basis for the association between UFORs and seismic activity, the hypothesis, and laboratory experiments. It is emphasized that criticisms of data should be based upon empirical criteria rather than value judgments about scientific credibility. Multivariate and bivariate analyses have indicated systematic relationships between UFORs and earthquake measures within several different areas and for different historical periods. However, the physical mechanisms for the generation of individual UFO events and their relationship to UFORs require closer examination.

  14. Past-life identities, UFO abductions, and satanic ritual abuse: the social construction of memories.

    Science.gov (United States)

    Spanos, N P; Burgess, C A; Burgess, M F

    1994-10-01

    People sometimes fantasize entire complex scenarios and later define these experiences as memories of actual events rather than as imaginings. This article examines research associated with three such phenomena: past-life experiences, UFO alien contact and abduction, and memory reports of childhood ritual satanic abuse. In each case, elicitation of the fantasy events is frequently associated with hypnotic procedures and structured interviews which provide strong and repeated demands for the requisite experiences, and which then legitimate the experiences as "real memories." Research associated with these phenomena supports the hypothesis that recall is reconstructive and organized in terms of current expectations and beliefs.

  15. Geophysical variables and behavior: XXI. Geomagnetic variation as possible enhancement stimuli for UFO reports preceding earthtremors.

    Science.gov (United States)

    Persinger, M A

    1985-02-01

    The contribution of geomagnetic variation to the occurrence of UFORs (reports of UFOs) within the New Madrid States during the 6-mo. increments before increases in the numbers of IV-V or less intensity earthquakes within the central USA was determined. Although statistically significant zero-order correlations existed between measures of earthquakes, UFORs and geomagnetic variability, the association between the latter two deteriorated markedly when their shared variance with earthquakes was held constant. These outcomes are compatible with the hypothesis that geomagnetic variability (or phenomena associated with it) may enhance UFORs but only if tectonic stress and strain are increasing within the region.

  16. The prognostic value of pretreatment CA-125 levels and CA-125 normalization in ovarian clear cell carcinoma: a two-academic-institute study.

    Science.gov (United States)

    Bai, Huimin; Sha, Guisha; Xiao, Meizhu; Gao, Huiqiao; Cao, Dongyan; Yang, Jiaxin; Chen, Jie; Wang, Yue; Zhang, Zhenyu; Shen, Keng

    2016-03-29

    The present study investigated the clinical implications of pretreatment carbohydrate antigen 125 (CA-125) levels and CA-125 normalization in patients with ovarian clear cell carcinoma (CCC), and it provides useful information for the improvement of monitoring strategies for this lethal disease. The medical records of patients with ovarian CCC who had undergone primary staging surgery or cytoreductive surgery followed by systemic chemotherapy were retrospectively reviewed. A range of clinico-pathological parameters were collected and examined. A total of 375 women were included in the analysis. FIGO stage (p CA-125 levels included advanced-stage disease, positive residual tumors and negative endometriosis (p CA-125 levels were not associated with relapse-free survival (RFS) or overall survival (OS) (p = 0.060 and p = 0.176, respectively). CA-125 normalization after chemotherapy exhibited a positive linear correlation with advanced stage (r = 0.97, p = 0.001) and residual tumor (r = 0.81, p = 0.027) and a negative relationship with 5-year RFS (r = -0.97, p = 0.002) and 5-year OS (r = -0.97, p= 0.001). Patients with CA-125 levels that normalized before cycle 2 of chemotherapy had a similar prognosis as patients whose CA-125 levels normalized prior to chemotherapy (RFS: p = 0.327; OS: p = 0.654). By contrast, patients with CA-125 levels that normalized after cycle 2 of chemotherapy or never normalized were significantly more likely to experience disease progression. Pretreatment CA-125 levels are not very useful for predicting clinical outcome. CA-125 levels following treatment are a valid indicator for treatment monitoring. CA-125 normalization after the completion of cycle 1 of chemotherapy represents a distinct inflection point for decreased RFS and OS.

  17. Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.

    Science.gov (United States)

    Braunger, J; Schleithoff, L; Schulz, A S; Kessler, H; Lammers, R; Ullrich, A; Bartram, C R; Janssen, J W

    1997-06-05

    Ufo/Axl belongs to a new family of receptor tyrosine kinases with an extracellular structure similar to that of neural cell adhesion molecules. In order to elucidate intracellular signaling, the cytoplasmic moiety of Ufo/Axl was used to screen an expression library according to the CORT (cloning of receptor targets) method. Three putative Ufo substrates were identified: phospholipase Cgamma1 (PLCgamma), as well as p85alpha and p85beta subunits of phosphatidylinositol 3'-kinase (PI3-kinase). Subsequently, chimeric EGFR/Ufo receptors consisting of the extracellular domains of the epidermal growth factor receptor (EGFR) and the transmembrane and intracellular moiety of Ufo were engineered. Using different far-Western blot analyses and coimmunoprecipitation assays, receptor binding of PLCgamma and p85 proteins as well as GRB2, c-src and lck was examined in vitro and in vivo. Competitive inhibition of substrate binding and mutagenesis experiments with EGFR/Ufo constructs revealed C-terminal tyrosine 821 (EILpYVNMDEG) as a docking site for multiple effectors, namely PLCgamma, p85 proteins, GRB2, c-src and lck. Tyrosine 779 (DGLpYALMSRC) demonstrated an additional, but lower binding affinity for the p85 proteins in vitro. In addition, binding of PLCgamma occurred through tyrosine 866 (AGRpYVLCPST). Moreover, our in vivo data indicate that further direct or indirect binding sites for PLCgamma, GRB2, c-src and lck on the human Ufo receptor may exist.

  18. Extended studies on the effect of glutamate antagonists on ischemic CA-1 damage

    DEFF Research Database (Denmark)

    Diemer, Nils Henrik; Balchen, T; Bruhn, T

    1996-01-01

    Glutamate receptors are numerous on the ischemia vulnerable CA-1 pyramidal cells. Postischemic use of the AMPA antagonist NBQX has shown up to 80% protection against cell death. Three aspects of this were studied: In the first study, male Wistar rats were given NBQX (30 mg/kg x 3) either 20 hours...... in the present model, eosinophilic CA-1 cells are seen from day 2 on. Since there could be a late, deleterious calcium influx via NMDA receptors, one group of ischemic rats was given MK-801 (5 mg/kg i.p.) 24 hours after ischemia. However, quantitation 6 days later of remaining CA-1 cells showed no protection...

  19. Association between serum CA 19-9 and metabolic syndrome: A cross-sectional study.

    Science.gov (United States)

    Du, Rui; Cheng, Di; Lin, Lin; Sun, Jichao; Peng, Kui; Xu, Yu; Xu, Min; Chen, Yuhong; Bi, Yufang; Wang, Weiqing; Lu, Jieli; Ning, Guang

    2017-11-01

    Increasing evidence suggests that serum CA 19-9 is associated with abnormal glucose metabolism. However, data on the association between CA 19-9 and metabolic syndrome is limited. The aim of the present study was to investigate the association between serum CA 19-9 and metabolic syndrome. A cross-sectional study was conducted on 3641 participants aged ≥40 years from the Songnan Community, Baoshan District in Shanghai, China. Logistic regression analysis was used to evaluate the association between serum CA 19-9 and metabolic syndrome. Multivariate logistic regression analysis showed that compared with participants in the first tertile of serum CA 19-9, those in the second and third tertiles had increased odds ratios (OR) for prevalent metabolic syndrome (multivariate adjusted OR 1.46 [95% confidence interval {CI} 1.11-1.92] and 1.51 [95% CI 1.14-1.98]; P trend  = 0.005). In addition, participants with elevated serum CA 19-9 (≥37 U/mL) had an increased risk of prevalent metabolic syndrome compared with those with serum CA 19-9 metabolic syndrome. In order to confirm this association and identify potential mechanisms, prospective cohort and mechanic studies should be performed. © 2017 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.

  20. Neutron-scattering studies of the doubly magic Ca nuclei, 40Ca and 48Ca, in the low-energy resonance region

    International Nuclear Information System (INIS)

    Hicks, S.F.

    1988-01-01

    Measurements of neutron elastic and inelastic scattering differential cross sections from 48 Ca at 2.35, 2.43, 2.71, 3.15, 3.55, 4.70, 6.00, and 7.97 MeV are presented. These data are combined with n + 48 Ca total cross sections taken at Oak Ridge National Laboratory to form a rather extensive set of scattering data for 48 Ca between 80 keV and 20 MeV incident neutron energy. Coupled-channels analyses of these data with a first-order vibrational model described both the neuron inelastic cross sections at 7.97 MeV and intermediate structure resonances observed in the total cross sections below 3 MeV. Particle-core coupled resonance configurations were determined for four intermediate structure resonances from the coupled-channels calculations. Also measured at each of the energies listed above were neutron elastic and inelastic cross sections from 40 Ca. In addition to the above coupled-channels analysis of 48 Ca, the mean field potential used to describe the bound-state and scattering data of 48 Ca was determined using a dispersion relation to connect the real and imaginary components of the optical model potential. Finally, differential scattering cross sections measured between 2 and 3.5 MeV from 48 Ca are compared to calculations using phase shifts from an evaluation of the total cross sections. The agreement between the measured and calculated differential scattering cross sections was excellent at some energies

  1. The ASK1 gene regulates development and interacts with the UFO gene to control floral organ identity in Arabidopsis.

    Science.gov (United States)

    Zhao, D; Yang, M; Solava, J; Ma, H

    1999-09-01

    Normal flower development likely requires both specific and general regulators. We have isolated an Arabidopsis mutant ask1-1 (for -Arabidopsis skp1-like1-1), which exhibits defects in both vegetative and reproductive development. In the ask1-1mutant, rosette leaf growth is reduced, resulting in smaller than normal rosette leaves, and internodes in the floral stem are shorter than normal. Examination of cell sizes in these organs indicates that cell expansion is normal in the mutant, but cell number is reduced. In the mutant, the numbers of petals and stamens are reduced, and many flowers have one or more petals with a reduced size. In addition, all mutant flowers have short stamen filaments. Furthermore, petal/stamen chimeric organs are found in many flowers. These results indicate that the ASK1 gene affects the size of vegetative and floral organs. The ask1 floral phenotype resembles somewhat that of the Arabidopsis ufo mutants in that both genes affect whorls 2 and 3. We therefore tested for possible interactions between ASK1 and UFO by analyzing the phenotypes of ufo-2 ask1-1 double mutant plants. In these plants, vegetative development is similar to that of the ask1-1 single mutant, whereas the floral defects are more severe than those in either single mutant. Interior to the first whorl, the double mutant flowers have more sepals or sepal-like organs than are found in ufo-2, and less petals than ask1-1. Our results suggest that ASK1 interacts with UFO to control floral organ identity in whorls 2 and 3. This is very intriguing because ASK1 is very similar in sequence to the yeast SKP1 protein and UFO contains an F-box, a motif known to interact with SKP1 in yeast. Although the precise mechanism of ASK1 and UFO action is unknown, our results support the hypothesis that these two proteins physically interact in vivo. Copyright 1999 Wiley-Liss, Inc.

  2. Ghosts, UFOs, and magic: positive affect and the experiential system.

    Science.gov (United States)

    King, Laura A; Burton, Chad M; Hicks, Joshua A; Drigotas, Stephen M

    2007-05-01

    Three studies examined the potential interactions of the experiential system and positive affect (PA) in predicting superstitious beliefs and sympathetic magic. In Study 1, experientiality and induced positive mood interacted to predict the emergence of belief in videos purporting to show unidentified flying objects or ghosts. In Study 2, naturally occurring PA interacted with experientiality to predict susceptibility to sympathetic magic, specifically difficulty in throwing darts at a picture of a baby (demonstrating the law of similarity). In Study 3, induced mood interacted with experientiality to predict sitting farther away from, and expressing less liking for, a partner who had stepped in excrement (demonstrating the law of contagion). Results are interpreted as indicating that PA promotes experiential processing. Implications for the psychology of nonrational beliefs and behaviors are discussed. ((c) 2007 APA, all rights reserved).

  3. Structural studies and c dependence in La 2- Dy Ca Ba 2 ...

    Indian Academy of Sciences (India)

    ... room temprerature on = 0.3 and 0.5 samples are reported. It is interesting to know that Ca substitutes for both La and Ba site with concomitant displacement of La onto Ba site. Superconductivity studies show that maximum c is obtained for = 0.5, = 1.0 sample (c ∼ 75 K), for La1.5Dy0.5Ca1Ba2Cu5O (La-2125).

  4. ECOs, FOBs, and UFOs: making sense of observational data.

    Science.gov (United States)

    Ross Ross, J F

    2000-01-01

    Systematic observations of rat behavior are required for both standard subchronic safety studies and for neurotoxicity studies. The requirements specify subjective out-of-cage observations (eg, posture, gait, and reactivity to various stimuli such as, auditory, tactile, and noxious) using defined scales. Measurement of forelimb/hind limb grip strength, landing foot splay, and locomotor activity are also required. The observational endpoints are organized into a battery, eg, the Environmental Protection Agency functional observational battery (FOB) or expanded clinical observations (ECO). Functional and neuropathologic data are most easily integrated when the functional endpoints are organized as a neurologic exam (ie, each endpoint has a known anatomical basis and there are sufficient endpoints to cover the nervous system). Current batteries do not constitute a neurologic exam. Although ECOs and FOBs contain some components of a neurologic exam (ie, observations of gait, response to pinch), the anatomic basis for other components (eg, hind limb splay) is poorly defined. And although some functions (eg, somatomotor) are well characterized by current batteries, others (eg, vision, somatosensation) are evaluated less effectively. The measurement of locomotor activity in a novel environment is one of the most problematic parts of current functional testing batteries, although contemporary technology may provide opportunities for improving this test. The influence of inherent limitations of functional test methods is magnified by factors associated with testing for neurotoxicant-related effects during safety studies. First, most personnel at contract laboratories have little or no formal training in conducting and interpreting a neurologic examination. Second, most neurotoxicant-related lesions are bilateral, which paradoxically may produce more subtle effects than unilateral lesions. Third, most chemicals will be tested only once, and sponsors are reluctant to evaluate

  5. Physiological studies in heterozygous calcium sensing receptor (CaSR gene-ablated mice confirm that the CaSR regulates calcitonin release in vivo

    Directory of Open Access Journals (Sweden)

    Kovacs Christopher S

    2004-04-01

    Full Text Available Abstract Background The calcium sensing receptor (CaSR regulates serum calcium by suppressing secretion of parathyroid hormone; it also regulates renal tubular calcium excretion. Inactivating mutations of CaSR raise serum calcium and reduce urine calcium excretion. Thyroid C-cells (which make calcitonin express CaSR and may, therefore, be regulated by it. Since calcium stimulates release of calcitonin, the higher blood calcium caused by inactivation of CaSR should increase serum calcitonin, unless CaSR mutations alter the responsiveness of calcitonin to calcium. To demonstrate regulatory effects of CaSR on calcitonin release, we studied calcitonin responsiveness to calcium in normal and CaSR heterozygous-ablated (Casr+/- mice. Casr+/- mice have hypercalcemia and hypocalciuria, and live normal life spans. Each mouse received either 500 μl of normal saline or one of two doses of elemental calcium (500 μmol/kg or 5 mmol/kg by intraperitoneal injection. Ionized calcium was measured at baseline and 10 minutes, and serum calcitonin was measured on the 10 minute sample. Results At baseline, Casr+/- mice had a higher blood calcium, and in response to the two doses of elemental calcium, had greater increments and peak levels of ionized calcium than their wild type littermates. Despite significantly higher ionized calcium levels, the calcitonin levels of Casr+/- mice were consistently lower than wild type at any ionized calcium level, indicating that the dose-response curve of calcitonin to increases in ionized calcium had been significantly blunted or shifted to the right in Casr+/- mice. Conclusions These results confirm that the CaSR is a physiological regulator of calcitonin; therefore, in response to increases in ionized calcium, the CaSR inhibits parathyroid hormone secretion and stimulates calcitonin secretion.

  6. Study on 41Ca-AMS for diagnosis and assessment of cancer bone metastasis in rats

    Science.gov (United States)

    Shen, Hongtao; Pang, Fangfang; Jiang, Shan; He, Ming; Dong, Kejun; Dou, Liang; Pang, Yijun; Yang, Xianlin; Ruan, Xiangdong; Liu, Manjun; Xia, Chunbo

    2015-10-01

    The annual incidence of new cancer patients in China is about 2 million, 30-40% of which will end up with bone metastasis. Profound study on the preclinical model and early diagnosis of cancer bone metastasis in rats are very significant for the drug development, better understanding and treatment of bone metastases. In order to monitor the process of bone metabolism and early detection of bone metastasis of cancer cells, a technique of 41Ca isotope tracer combined with AMS has been developed and applied in the study on the bone metastasis of cancer cells by rat model. In this work, 3-month-old female Sprague-Dawley (SD) rats were randomly divided into different groups, and tumor cells injected respectively into the tail vein, femoral artery, femoral cavity and the thigh muscle to establish the rat models for bone metastases. The most appropriate model, i.e., the thigh muscle group, was finally adopted in our real metastases experiment. Each rat in this group was intramuscularly (i.m.) injected with 250 μl CaCl2 solution (containing 1.4 mg Ca and 5nCi 41Ca). About 40 days later, the rat mammary gland carcinoma cells (Walker 256) were injected into these rats following the established protocol. After bone metastasis, medicine interventions were performed. The sequential urine and blood samples were collected and analyzed for 41Ca (by AMS) and N-terminal telopeptide (Ntx), respectively. Bone Mineral Density (BMD) values in the femur and the tibia were measured by CT scan. The results of 41Ca/Ca in longitudinal urinary samples can sensitively reveal the skeletal perturbations caused by bone metastasis of rats, suggests that 41Ca might be similarly developed for human use and improve clinical management through the assessment of the curative effect and non-invasive detection of the earliest stages of cancer growth in bone.

  7. Study of Ca-ATMP precipitation in the presence of magnesium ion.

    Science.gov (United States)

    Tantayakom, V; Fogler, H Scott; de Moraes, F F; Bualuang, M; Chavadej, S; Malakul, P

    2004-03-16

    ATMP (aminotri(methylenephosphonic acid)), a phosphonate scale inhibitor used in the petroleum industry, was used as a model scale inhibitor in this study. One of the goals of this work was to determine the range of conditions under which Mg ions, which are formed in reservoir formations containing dolomite, modulate the formation of Ca-ATMP precipitate as a scale inhibitor. The results revealed that the amount of ATMP precipitated decreased with addition of Mg ions in solution at all values of the solution pH. Furthermore, an increase in both the solution pH and the concentration of the divalent cations in solution resulted in a change of the molar ratio of (Ca + Mg) to ATMP in the precipitates. At a low solution pH (pH 1.5), Mg ions had little effect on the composition of the Ca-ATMP precipitate. However, at higher values of the solution pH (pH 4 and 7), the Ca to ATMP molar ratio in the precipitates decreased with increasing concentration of the Mg. Here it was found that Mg ions replaced Ca ions on available reactive sites of ATMP molecules. These results determined the limits of the Mg ion concentration, which affects the precipitation of Ca-ATMP, Mg-ATMP, and (Ca + Mg)-ATMP. The dissolution of the scale inhibitors was studied using a rotating disk reactor. These experiments showed that the total divalent cation molar ratio (Ca + Mg) to ATMP in the precipitates is the primary factor that controls the rate of dissolution (release) of the phosphonate precipitates. The phosphonate precipitate dissolution rates decreased as the molar ratio of divalent cations to ATMP in the precipitates increased.

  8. Mechanical and microstructure studies on the modification of CA film ...

    Indian Academy of Sciences (India)

    Unknown

    Bull. Mater. Sci., Vol. 25, No. 1, February 2002, pp. 25–29. © Indian Academy of Sciences. 25. Mechanical and microstructure studies on the modification ... Liu et al (1996) prepared reverse osmosis membrane by graft copoly- merizing acrylonitrile onto cellulose acetate. They also reported optimum conditions for getting a ...

  9. Mechanical and microstructure studies on the modification of CA film ...

    Indian Academy of Sciences (India)

    The films of these composites or their individual partners were made separately and studied for their mechanical properties, chemical modification and morphological changes. We report here that banana stem is good source of cellulose and that cellulose completely undergoes modification upon esterification.

  10. Electron microscopic studies on odontoblasts using 45Ca as the tracer

    International Nuclear Information System (INIS)

    Okamoto, Eiji

    1980-01-01

    In order to study the relationship between odontoblasts and inorganic salts, odontoblasts of 10-day old rats' incisions and molars were used. The animals were sacrificed 15 minutes, 30 minutes, 1 hour or 2 hours after 45 Ca administration to obtain the specimen. The specimens were processed for electron microscopic autoradiography. 15 minutes after 45 Ca administration, silver grains indicated 45 Ca uptake was already noted within the cells. 45 Ca was localized in the mitochondria, Golgi area, rough surfaced endoplasmic reticulum and partially within the karyoplasm. After 30 minutes' administration, the number of silver grains were generally increased as compared with the findings obtained after 15 minutes' administration. The localization was similar with those after 15 minutes' administration but some were found in the ribosomes and smooth surfaced endoplasmic reticulum with numerous silver grains within small vesicles derived from the Golgi apparatus as well. A movement of 45 Ca from the protruding part to the stroma was also noted. 1 hour after the administration, the number of silver grains were generally decreased, with a more pronounced movement towards stroma from the protruding part. The marked movement of silver grains was obtained onto the collagen fibers in the stroma. In the mitochondria, however, considerable number of silver grains were still seen. In this section, on the other hand, numerous silver grains were seen in the intercellular space, in addition to the pathway of intracellular route, indicating the Ca shift from outside of the cells. After 2 hours' 45 Ca administration, the tendency towards the decrease of the silver grains became more remarkable, the movement of 45 Ca via the extracellular pathway described above was also frequently found. (author)

  11. Computer simulation and high level virial theory of Saturn-ring or UFO colloids

    Science.gov (United States)

    Bates, Martin A.; Dennison, Matthew; Masters, Andrew

    2008-08-01

    Monte Carlo simulations are used to map out the complete phase diagram of hard body UFO systems, in which the particles are composed of a concentric sphere and thin disk. The equation of state and phase behavior are determined for a range of relative sizes of the sphere and disk. We show that for relatively large disks, nematic and solid phases are observed in addition to the isotropic fluid. For small disks, two different solid phases exist. For intermediate sizes, only a disordered fluid phase is observed. The positional and orientational structure of the various phases are examined. We also compare the equations of state and the nematic-isotropic coexistence densities with those predicted by an extended Onsager theory using virial coefficients up to B8.

  12. Intelligent Design, A Young Universe, Astrology, UFO's, and More: Tackling Astronomical Pseudo-science

    Science.gov (United States)

    Fraknoi, A.

    2008-11-01

    During IYA educators and scientists will interact with the public in many ways. There will likely be public questions at IYA events about pseudo-scientific topics. While the particular pseudo-sciences that are in vogue change with time, these days popular astronomical pseudo-science includes creationism and intelligent design (and their denial of the age of the universe), astrology, UFO's as extra-terrestrial spaceships, selling star names, the ``face'' on Mars, the claim that the moon landings were a hoax, etc. We discuss some of the recent surveys of belief in pseudo-science and some ways to respond to questions about these topics. A separate resource guide to help answer questions about astronomical pseudoscience is also included in this volume.

  13. Computer simulation and high level virial theory of Saturn-ring or UFO colloids.

    Science.gov (United States)

    Bates, Martin A; Dennison, Matthew; Masters, Andrew

    2008-08-21

    Monte Carlo simulations are used to map out the complete phase diagram of hard body UFO systems, in which the particles are composed of a concentric sphere and thin disk. The equation of state and phase behavior are determined for a range of relative sizes of the sphere and disk. We show that for relatively large disks, nematic and solid phases are observed in addition to the isotropic fluid. For small disks, two different solid phases exist. For intermediate sizes, only a disordered fluid phase is observed. The positional and orientational structure of the various phases are examined. We also compare the equations of state and the nematic-isotropic coexistence densities with those predicted by an extended Onsager theory using virial coefficients up to B(8).

  14. Fabrication and formation studies on single-walled CA/NaCS-WSC microcapsules.

    Science.gov (United States)

    Wu, Qing-Xi; Lin, Dong-Qiang; Yao, Shan-Jing

    2016-02-01

    The micron-sized calcium alginate/sodium cellulose sulfate-water soluble chitosan (CA/NaCS-WSC) microcapsules were prepared by membrane emulsification method using sodium alginate (NaAlg), NaCS and WSC as raw materials. The CA/NaCS microspheres prepared dispersed well and held spherical shape with an emulsifier volume ratio of 7:3 (Span 80:Tween 80) and a concentration of cross-linking agent of 1.5% (w/v) calcium chloride and 5% (w/v) sodium chloride. The CA/NaCS-WSC microcapsules had a spherical shape with average diameter of 62.36±13.87μm. A fluorescent ring could be seen obviously on the surface of CA/NaCS-WSC microcapsules under confocal microscope, when WSC was labeled by fluorescein isothiocyanate. The discussion on the formation studies implied that Ca(2+) could diffuse into the droplets of NaAlg/NaCS forming CA/NaCS microspheres, while NaCS could react with WSC forming a polyelectrolyte complexes film. The microcapsules prepared with typical wall-capsule/core structure could be used to develop micron-sized drug delivery carriers. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Possible room temperature ferromagnetism in Ca-doped AlP: First-principles study

    International Nuclear Information System (INIS)

    Zhang, Yong

    2013-01-01

    Based on first-principle calculations, we have studied the electronic and magnetic properties of AlP with aluminium vacancy and calcium doping. It was found that while Al vacancy and Ca impurity themselves are nonmagnetic, they generate holes residing in P 2p orbitals that lead to magnetic moments in AlP. The coupling between two Al vacancies in AlP are always antiferromagnetic because of half-filled t 2 level. However, the coupling becomes ferromagnetic with large magnetic energy when vacancies are replaced by nonmagnetic Ca atoms. Moreover, the presence of Ca dopants reduces the formation energy of Al vacancy. These results suggest that Ca-doped AlP is a promising room temperature ferromagnetic semiconductor free of magnetic precipitates, and it may find applications in the field of spintronics. - Highlights: • “d 0 ferromagnetism” has been found in Ca-doped AlP. • Unpaired t 2 state of P atoms has an important impact on magnetic properties. • Room temperature T C may be expected in Ca-doped AlP

  16. Novel method for the study of receptor Ca2+ signalling exemplified by the NK1 receptor

    DEFF Research Database (Denmark)

    Heding, A; Elling, C E; Schwartz, T W

    2002-01-01

    We have used a novel technology (NovoStar from BMG Labtechnologies) for the study of the Ca2+ signalling of the human tackykinin NK1 (hNK-I receptor). The NovoStar is a microplate reader based on fluorescence and luminescence. The instrument implements a robotic pipettor arm and two microplate...... carriers, typically one for samples and one for cells. The robotic pipettor arm can transfer sample (agonist or antagonist) from the sample plate or other liquid containers to the cell plate, facilitating the study of Ca2+ signalling to such a degree that the instrument can be used for Medium Throughput...

  17. Geophysical variables and behavior: LIII. Epidemiological considerations for incidence of cancer and depression in areas of frequent UFO reports.

    Science.gov (United States)

    Persinger, M A

    1988-12-01

    Luminous phenomena and anomalous physical forces have been hypothesized to be generated by focal tectonic strain fields that precede earthquakes. If these geophysical processes exist, then their spatial and temporal density should be greatest during periods of protracted, localized UFO reports; they might be used as dosimetric indicators. Contemporary epidemiological data concerning the health risks of power frequency electromagnetic fields and radon gas levels (expected correlates of certain tectonic strain fields), suggest that increased incidence (odds ratios greater 1:3) of brain tumors and leukemia should be evident within "flap" areas. In addition the frequency of variants of temporal lobe lability, psychological depression and posttraumatic stress should be significantly elevated. UFO field investigators, because they have repeated, intermittent close proximity to these fields, are considered to be a particularly high risk population for these disorders.

  18. Geophysical variables and behavior: LIII. Epidemiological considerations for incidence of cancer and depression in areas of frequent UFO reports

    International Nuclear Information System (INIS)

    Persinger, M.A.

    1988-01-01

    Luminous phenomena and anomalous physical forces have been hypothesized to be generated by focal tectonic strain fields that precede earthquakes. If these geophysical processes exist, then their spatial and temporal density should be greatest during periods of protracted, localized UFO reports; they might be used as dosimetric indicators. Contemporary epidemiological data concerning the health risks of power frequency electromagnetic fields and radon gas levels (expected correlates of certain tectonic strain fields), suggest that increased incidence (odds ratios greater 1:3) of brain tumors and leukemia should be evident within flap areas. In addition the frequency of variants of temporal lobe lability, psychological depression and posttraumatic stress should be significantly elevated. UFO field investigators, because they have repeated, intermittent close proximity to these fields, are considered to be a particularly high risk population for these disorders. 22 references

  19. Study on rapid bio-drying technology of cow dung with CaO2

    Science.gov (United States)

    Chen, Xiaotian; Qu, Guangfei; Liu, Shugen; Xie, Ruosong; He, Yanhua

    2017-05-01

    Effect of CaO2 on cow dung rapid bio-drying technology was researched. A static aerobic composting system was applied to this experiment which combining natural ventilation with Turing in the process of composting. The physical characteristics of cow dung was observed and the compost temperature, moisture content, organic matter, total nitrogen, total phosphorus, potassium content was determined which in order to study the effect of CaO2 on rapid drying of cattle in the compost. In the initial stage of compost, adding CaO2 groups compared with the control group, the temperature rise faster, 4-6 days in advance to the thermophilic phase; at the end of composting, the CaO2 composition and moisture content decreased significantly to below 30%. The addition of CaO2 in fertilizer was shorten the composting time, extend the thermophilic phase, to provide sufficient oxygen meeting the growth needs of aerobic microorganisms. It convinced that the rapid bio-drying of dairy manure has a good effect and provided a new idea for the effective treatment of cow dung.

  20. Corrosion study of resorbable Ca60Mg15Zn25 bulk metallic glasses in physiological fluids

    Directory of Open Access Journals (Sweden)

    Rafał Babilas

    2017-10-01

    Full Text Available The corrosion activity of amorphous plates of Ca60Mg15Zn25 alloy was investigated. The biocompatible elements were selected for the alloy composition. The electrochemical corrosion and immersion tests were carried out in a multi-electrolyte fluid and Ringer's solution. Better corrosion behavior was observed for the samples tested in a multi-electrolyte fluid despite the active dissolution of Ca and Mg in Ringer's solution. The experimental results indicated that reducing concentration of NaCl from 8.6 g/dm3 for Ringer's solution to 5.75 g/dm3 caused the decrease of the corrosion rate. The volume of the hydrogen evolved after 480 min in Ringer's solution (40.1 ml/cm2 was higher in comparison with that obtained in a multi-electrolyte fluid (24.4 ml/cm2. The values of open-circuit potential (EOCP for the Ca60Mg15Zn25 glass after 1 h incubation in Ringer's solution and a multi-electrolyte fluid were determined to be −1553 and −1536 mV vs. a saturated calomel electrode (SCE. The electrochemical measurements indicated a shift of the corrosion current density (jcorr from 1062 μA/cm2 for the sample tested in Ringer's solution to 788 μA/cm2 for the specimen immersed in a multi-electrolyte fluid. The corrosion products analysis was conducted by using the X-ray photoelectron spectroscopy (XPS. The corrosion products were identified to be CaCO3, Mg(OH2, CaO, MgO and ZnO. The mechanism of corrosion process was proposed and described based on the microscopic observations. The X-ray diffraction and Fourier transform infrared spectroscopy (FTIR also indicated that Ca(OH2, CaCO3, Zn(OH2 and Ca(Zn(OH32·2H2O mainly formed on the surface of the studied alloy. Keywords: Ca-based metallic glasses, X-ray photoelectron spectroscopy, FTIR spectroscopy, X-ray diffraction, Corrosion resistance, Hydrogen evaluation

  1. Molecular studies of BKCa channels in intracranial arteries

    DEFF Research Database (Denmark)

    Wulf, Helle; Hay-Schmidt, Anders; Poulsen, Asser Nyander

    2008-01-01

    expression of the BK(Ca) channel in rat basilar, middle cerebral, and middle meningeal arteries by reverse transcription polymerase chain reaction (RT-PCR), quantitative real-time PCR, and Western blotting. Distribution patterns were investigated using in situ hybridization and immunofluorescence studies. RT......-PCR and quantitative real-time PCR detected the expression of the BK(Ca) channel mRNA transcript in rat basilar, middle cerebral, and middle meningeal arteries, with the transcript being expressed more abundantly in rat basilar arteries than in middle cerebral and middle meningeal arteries. Western blotting detected...... and localization of both mRNA and protein expression of the BK(Ca) channel in the smooth muscle cell layer in rat basilar, middle cerebral, and middle meningeal arteries....

  2. Preliminary study of experimental tumor radioimmunoimagination in animals by CA-50 monoclonal antibody

    International Nuclear Information System (INIS)

    Chen zhizhou

    1988-01-01

    The 125 I labelling of CA-50 monoclonal antibody, the distribution of radioactivity in experimental lung cancer 739 bearing mice, and tumor radioimmunoimagination were studied. At 24 hrs after the i.v. administrations of 5.55∼8.14 MBq 125 I-CA50, the relative values of radioactivity in different tissues were: muscle 1, blood 4.1, heart 1.4, liver 6.7, spleen 2.2, lung 2.8, kidney 5.3, tumor 14.5. Radioimmunoimagination showed clearly the locatization of the tumor

  3. Neutron diffraction studies on La 2- Dy Ca 2 Ba 2 Cu 4+2

    Indian Academy of Sciences (India)

    Structural studies on Dy-substituted La-2125 type superconductors have been carried out by neutron diffraction experiments at room temperature using a monochromatic neutron beam of wavelength () = 1.249 Å. A series of samples with La2-DyCa2Ba2Cu4+2O stoichiometric composition, for = 0.1-0.5, have ...

  4. Study of gel grown mixed crystals of Bax Ca ((IO3) 4

    Indian Academy of Sciences (India)

    The growth of mixed crystals of BaCa1–(IO3)4 were carried out with simple gel method. The effect of various parameters such as pH of gel solution, gel concentration, gel setting time, concentration of reactants on the growth was studied. Crystals having different morphologies and habits were obtained. The grown ...

  5. TPR and TPD studies of effects of Cu and Ca promotion on Fe-Zn ...

    Indian Academy of Sciences (India)

    www.ias.ac.in/article/fulltext/jcsc/125/03/0679-0686 ... Temperature-programmed reduction (TPR) and temperature-programmed desorption (TPD) were used to study the effects of Cu and Ca promotion on Fe-Zn-based Fischer-Tropsch catalysts.

  6. Chronic Stress Improves NO- and Ca2+ Flux-Dependent Vascular Function: A Pharmacological Study

    Energy Technology Data Exchange (ETDEWEB)

    Bruder-Nascimento, Thiago, E-mail: bruderthiago@usp.br [Departamento de Farmacologia - Instituto de Biociências de Botucatu - Universidade do Estado de São Paulo (UNESP), Botucatu, São Paulo (Brazil); Departamento de Clínica Médica - Faculdade de Medicina de Botucatu - Universidade do Estado de São Paulo (UNESP), Botucatu, São Paulo (Brazil); Campos, Dijon Henrique Salome [Departamento de Clínica Médica - Faculdade de Medicina de Botucatu - Universidade do Estado de São Paulo (UNESP), Botucatu, São Paulo (Brazil)

    2015-03-15

    Stress is associated with cardiovascular diseases. This study aimed at assessing whether chronic stress induces vascular alterations, and whether these modulations are nitric oxide (NO) and Ca2+ dependent. Wistar rats, 30 days of age, were separated into 2 groups: control (C) and Stress (St). Chronic stress consisted of immobilization for 1 hour/day, 5 days/week, 15 weeks. Systolic blood pressure was assessed. Vascular studies on aortic rings were performed. Concentration-effect curves were built for noradrenaline, in the presence of L-NAME or prazosin, acetylcholine, sodium nitroprusside and KCl. In addition, Ca{sup 2+} flux was also evaluated. Chronic stress induced hypertension, decreased the vascular response to KCl and to noradrenaline, and increased the vascular response to acetylcholine. L-NAME blunted the difference observed in noradrenaline curves. Furthermore, contractile response to Ca{sup 2+} was decreased in the aorta of stressed rats. Our data suggest that the vascular response to chronic stress is an adaptation to its deleterious effects, such as hypertension. In addition, this adaptation is NO- and Ca{sup 2+}-dependent. These data help to clarify the contribution of stress to cardiovascular abnormalities. However, further studies are necessary to better elucidate the mechanisms involved in the cardiovascular dysfunction associated with stressors. (Arq Bras Cardiol. 2014; [online].ahead print, PP.0-0)

  7. Chronic Stress Improves NO- and Ca2+ Flux-Dependent Vascular Function: A Pharmacological Study

    Directory of Open Access Journals (Sweden)

    Thiago Bruder-Nascimento

    2015-03-01

    Full Text Available Background: Stress is associated with cardiovascular diseases. Objective: This study aimed at assessing whether chronic stress induces vascular alterations, and whether these modulations are nitric oxide (NO and Ca2+ dependent. Methods: Wistar rats, 30 days of age, were separated into 2 groups: control (C and Stress (St. Chronic stress consisted of immobilization for 1 hour/day, 5 days/week, 15 weeks. Systolic blood pressure was assessed. Vascular studies on aortic rings were performed. Concentration-effect curves were built for noradrenaline, in the presence of L-NAME or prazosin, acetylcholine, sodium nitroprusside and KCl. In addition, Ca2+ flux was also evaluated. Results: Chronic stress induced hypertension, decreased the vascular response to KCl and to noradrenaline, and increased the vascular response to acetylcholine. L-NAME blunted the difference observed in noradrenaline curves. Furthermore, contractile response to Ca2+ was decreased in the aorta of stressed rats. Conclusion: Our data suggest that the vascular response to chronic stress is an adaptation to its deleterious effects, such as hypertension. In addition, this adaptation is NO- and Ca2+-dependent. These data help to clarify the contribution of stress to cardiovascular abnormalities. However, further studies are necessary to better elucidate the mechanisms involved in the cardiovascular dysfunction associated with stressors. (Arq Bras Cardiol. 2014; [online].ahead print, PP.0-0

  8. Optical and structural studies of CaMoO{sub 4}:Sm, CaMoO{sub 4}:Sm@CaMoO{sub 4} and CaMoO{sub 4}:Sm@CaMoO{sub 4}@SiO{sub 2} core–shell nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Ansari, Anees A., E-mail: aneesaansari@gmail.com [King Abdullah Institute for Nanotechnology, King Saud University, P.O. Box 2455, Riyadh 11451 (Saudi Arabia); Alam, M. [Research Center, College of Science, King Saud University, P.O. Box 2455, Riyadh (Saudi Arabia)

    2015-01-15

    A simple polyol and Stober surface coating process was introduced to synthesize CaMoO{sub 4}:Sm and their silica-coated CaMoO{sub 4}:Sm nanoparticles. Powder X-ray diffraction (XRD) and different spectroscopic techniques were employed to investigate the structural and optical properties of as-prepared nanoparticles. The surface of CaMoO{sub 4}:Sm nanoparticles was modified to alter the solubility of the nanoparticles and to study the influence of surface coating on emission spectra of samarium ions. Optical properties of these nanoparticles showed a strong dependence on the surface modification of nanoparticles, indicating the influence of coating in the enhancement of luminescent intensity. These results were attributed to the formation of chemical bonds between CaMoO{sub 4}:Sm@ CaMoO{sub 4} core and non-crystalline SiO{sub 2} shell via Mo–O–Si bridges, which activate the ‘dormant’ Sm{sup 3+} ion on the surfaces of nanoparticles. It is, therefore, concluded that good hydrophilicity resulting from active functional groups in solutions and more intense luminescence enable doped core–shell nanoparticles to have great potential to be used as fluorescence biolabels in the future. - Highlights: • Synthesis of core and core–shell nanoparticles by a polyol method. • Structural study of the nanoparticles. • Comparative optical band gap and photoluminescence properties of the as-prepared nanoproducts.

  9. Study of a clusters in 40Ca and 40Ar through nuclear break-up

    International Nuclear Information System (INIS)

    Lefebvre, Laurent

    2013-01-01

    Nuclei are complex self-bound systems formed by nucleons. Conjointly to a mean-field picture in which nucleons can be regarded as independent particles, few nucleons might self-organize into compact objects, called clusters, inside the nucleus. It is theoretically predicted that it should manifest itself most strikingly for N = Z nuclei close to the emission thresholds and has been studied extensively in this region. We propose to study α-clusterization in the ground state of the N = Z 40 20 Ca 20 nucleus and the N (different of) Z 40 18 Ar 22 nucleus. We have studied the nuclear break-up of 40 Ca when the 40 Ar projectile passes by. If α clusters are preformed in 40 Ca, the probability of α-emission through nuclear break-up will be enhanced as compared to 40 Ar N (different of) Z nuclei.The nuclear break-up of 40 Ca was studied with an 40 Ar beam produced at GANIL at 35 MeV/A. The SPEG spectrometer was used to detect the heavy projectile with accurate resolution. The MUST2 Silicon detectors were placed around the target to measure the emitted α and the EXL calorimeter prototype was used to identify the γ rays from the decay of the residual 36 Ar and 36 S. A theoretical approach based on Time-Dependent Schroedinger Equation (TDSE) theory has been used to reproduce some experimental results like angular distributions. From the data analysis, we reconstructed excitation energy spectra and angular distributions which are compared to TDSE theory to extract some spectroscopic factors S α . These factors show that there is no more clusterization state in the ground state of the 40 Ca than in the ground state of 40 Ar. (author)

  10. Experimental and theoretical study to explain the morphology of CaMoO4 crystals

    Science.gov (United States)

    Oliveira, F. K. F.; Oliveira, M. C.; Gracia, L.; Tranquilin, R. L.; Paskocimas, C. A.; Motta, F. V.; Longo, E.; Andrés, J.; Bomio, M. R. D.

    2018-03-01

    CaMoO4 crystals were prepared by a controlled co-precipitation method and processed in a domestic microwave-assisted hydrothermal system with two different surfactants (ethyl 4-dimethylaminobenzoate and 1,2,4,5-benzenetetracarboxylic dianhydride). The corresponding structures were characterized by X-ray diffraction and Rietveld refinement techniques, Fourier transform infrared spectroscopy, ultraviolet-visible absorption spectroscopy, and photoluminescence measurements. Field emission scanning electron microscopy was used to investigate the morphology of the as-synthesized aggregates. The structure, the surface stability of the (001), (112), (100), (110), (101), and (111) surfaces of CaMoO4, and their morphological transformations were investigated through systematic first-principles calculations within the density functional theory method at the B3LYP level. Analysis of the surface structures showed that the electronic properties were associated with the presence of undercoordinated [CaOx] (x = 5 and 6) and [MoOy] (y = 4 and 3) clusters. The relative surfaces energies were tuned to predict a complete map of the morphologies available through a Wulff construction approach. The results reveal that the experimental and theoretical morphologies obtained coincide when the surface energies of the (001) and (101) surfaces increase, while the surface energy of the (100) facet decreases simultaneously. The results provide a comprehensive catalog of the morphologies most likely to be present under realistic conditions, and will serve as a starting point for future studies on the surface chemistry of CaMoO4 crystals.

  11. An Exploitation of Satellite-based Observation for Health Information: The UFOS Project

    International Nuclear Information System (INIS)

    Mangin, A.; Morel, M.; Fanton d'Andon, O.

    2000-01-01

    Short, medium and long-term trends of UV intensity levels are of crucial importance for either assessing effective biological impacts on human population, or implementing adequate preventive behaviours. Better information on a large spatial scale and increased public awareness of the short-term variations in UV values will help to support health agencies' goals of educating the public on UV risks. The Ultraviolet Forecast Operational Service Project (UFAS), financed in part by the European Commission/DG Information Society (TEN-TELECOM programme), aims to exploit satellite-based observations and to supply a set of UV products directly useful to health care. The short-term objective is to demonstrate the technical and economical feasibility and benefits that could be brought by such a system. UFOS is carried out by ACRI, with the support of an Advisory Group chaired by WHO and involving representation from the sectors of Health (WHO, INTERSUN collaborating centres, ZAMBON), Environment (WMO, IASB), and Telecommunications (EURECOM, IMET). (author)

  12. An Exploitation of Satellite-based Observation for Health Information: The UFOS Project

    Energy Technology Data Exchange (ETDEWEB)

    Mangin, A.; Morel, M.; Fanton d' Andon, O

    2000-07-01

    Short, medium and long-term trends of UV intensity levels are of crucial importance for either assessing effective biological impacts on human population, or implementing adequate preventive behaviours. Better information on a large spatial scale and increased public awareness of the short-term variations in UV values will help to support health agencies' goals of educating the public on UV risks. The Ultraviolet Forecast Operational Service Project (UFAS), financed in part by the European Commission/DG Information Society (TEN-TELECOM programme), aims to exploit satellite-based observations and to supply a set of UV products directly useful to health care. The short-term objective is to demonstrate the technical and economical feasibility and benefits that could be brought by such a system. UFOS is carried out by ACRI, with the support of an Advisory Group chaired by WHO and involving representation from the sectors of Health (WHO, INTERSUN collaborating centres, ZAMBON), Environment (WMO, IASB), and Telecommunications (EURECOM, IMET). (author)

  13. Clinical studies of intestinal 47Ca absorption test by external arm counter

    International Nuclear Information System (INIS)

    Ebisuno, Shoichi; Morimoto, Shigeyoshi; Torizumi, Kazutami; Yamada, Ryusaku; Ohta, Kiichiro; Ohkawa, Tadashi

    1984-01-01

    An arm counter used to measure fractional accumulation of 47 Ca on the forearm following an intravenous and a later oral dose of the radioisotope, and the intestinal 47 Ca absorption rate was calculated. Clinical studies were carried out in normal subjects and patients with some disorders of calcium metabolism, using this external counting techinique. The following results were obtained; (1) In 12 healthy control men (mean age 31.8 y), calcium absorption rate ranged from 42.5% to 59.6% (mean+-SD; 54.1+-4.7%). In 6 healthy women (mean age 31.4 y), the rate ranged from 46.8% to 57.3% (mean+-SD; 51.3+- 4.3%). The intestinal calcium absorption was not related to the sex in younger adult. (2) The fractional absorption of calcium were significantly increased in patients with primary hyperparathyroidism, whereas reduced in hypoparathyroidism. (3) In 5 female subjects affected by osteoporosis, a defective intestinal absorption of calcium was observed. (4) The calcium absorption tests were carried out on normo- and hypercalciuric patients with calcium urolithiasis. Higher absorption of calcium was recognized in some hypercalciuric patients. (5) In hypercalciuric calcium stone formers with rice-bran treatment, 47 Ca absorption from gut were decreased significantly. (6) This method is very convenient to determine the intestinal absorption of 47 Ca. When a protective covering of lead is prepared for scintiscanner, the 47 Ca absorption test can be done for the patients with calcium metabolic disorder on a routine examination. (author)

  14. Environmental change in the Limfjord, Denmark (ca 7500-1500 cal yrs BP): a multiproxy study

    Science.gov (United States)

    Lewis, Jonathan P.; Ryves, David B.; Rasmussen, Peter; Knudsen, Karen L.; Petersen, Kaj S.; Olsen, Jesper; Leng, Melanie J.; Kristensen, Peter; McGowan, Suzanne; Philippsen, Bente

    2013-10-01

    The Limfjord region of northern Jutland, Denmark, supports a rich archaeological record dating back to the Mesolithic, which documents long-term change in human practices and utilisation of marine resources since approximately 7500 BP. The presence and availability of marine resources in the Limfjord is sensitively regulated by environmental parameters such as salinity, sedimentary regime, nutrient status and primary productivity, but long-term changes in these parameters are currently poorly understood. In this study a multiproxy approach (including sedimentary parameters, diatoms, molluscs, foraminifera, sedimentary pigments, C and O stable isotopes and plant macrofossils) has been adopted to assess environmental change over the period ca 7500-1500 cal yrs BP at Kilen, a coastal fjord (before AD 1856) situated in the Western Limfjord. A diatom-based salinity transfer function based on a pan-Baltic training set has been applied to the fossil diatom dataset for quantitative assessment of salinity change over the study period. This study demonstrates that large-scale shifts in salinity are a common feature of the Limfjord's long-term history and are driven by the level of connection with the North Sea and the Skagerrak respectively, which in turn is likely driven by the complex interplay between climate, sea-level change, current velocity and rates of erosion/sedimentary accretion. Three shifts in state at Kilen are identified over the study period: a deep, periodically stratified fjord with medium-high salinity (and high productivity) between ca 7500-5000 BP, followed by a gradual transition to a shallow benthic system with more oceanic conditions (i.e. higher salinity, lower productivity, slower sedimentary accumulation rate and poorer fossil preservation) after ca 5000 BP and no stratification after ca 4400 BP, and lastly, within this shallow phase, an abrupt shift to brackish conditions around 2000 BP. Environmental-societal interactions are discussed on the

  15. Single-molecule, structural and functional studies of Listeria monocytogenes Ca2+-ATPase

    DEFF Research Database (Denmark)

    Dyla, Mateusz

    -ion transport (e.g. H+ for Ca2+-ATPases). P-type ATPases undergo major conformational changes during their functional cycle, as has been learned from a wealth of atomic-resolution X-ray crystallographic structures (4). In this work, single-molecule, structural and functional studies were employed to investigate...... the dynamics and mechanism of the transport cycle of P-type ATPase at a single molecule level. A representative P-type ATPase, the Listeria monocytogenes Ca2+-ATPase (LMCA1) was engineered and characterized to facilitate smFRET studies. Pairs of cysteines were introduced and reacted with maleimide derivatives...... transitions to the E2 state triggered by ATP binding and phosphorylation were very brief, and could only be characterized in a dephosphorylation-deficient LMCA1 mutant. Owing to a spontaneous dephosphorylation of this mutant, full transport cycles at a single-molecule resolution were observed for the first...

  16. Neutron Powder Diffraction Studies of Ca2-xSrxCoWO6 Double Perovskites

    International Nuclear Information System (INIS)

    Zhou, Qingdi; Kennedy, Brendan; Elcombe, Margaret

    2005-01-01

    Full text: A series of double perovskite compounds of A 2-x Sr x CoWO 6 (A = Ca, Ba) were synthesized and the room- and variable-temperature structural phase transitions have been studied by synchrotron and neutron powder diffraction techniques. These studies demonstrated that the symmetry increases as the average size of the A-site cation increases. These transitions are associated with the gradual reduction and ultimately removal of the octahedral tiles of the BO 6 octahedra. Temperature dependent structural studies have been undertaken for selected samples. The transition to cubic is continuous in the three Ca doped samples studied as a function of temperature, Ca 2-x Sr x CoWO 6 x = 1.8, 1.7, 1.6, however in each case analysis of the spontaneous strain shows the transition to be tricritical rather than second order in nature. Where observed the temperature induced P2 1 /n to I4/m transition is first order as required by symmetry. (authors)>>>>

  17. Study of very neutron-rich nuclei produced by means of a 48Ca beam

    International Nuclear Information System (INIS)

    Lewitowicz, M.; Artukh, A.G.

    1991-01-01

    The results of experiments with a 48 Ca beam performed at GANIL are presented and discussed. More than 30 very neutron-rich isotopes were identified or studied for the first time. The evidence for particle-unstable character of the 26 O isotope is reported. Half-life measurements for light neutron rich nuclei are compared with different theoretical predictions. (author) 14 refs.; 6 figs.; 1 tab

  18. DOE ZERH Case Study: Mutual Housing California, Mutual Housing at Spring Lake, Woodland, CA

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2015-09-01

    Case study of a DOE 2015 Housing Innovation Award winning multifamily project of 62 affordable-housing apartment home in the hot-dry climate that exceeded CA Title 24-2008 by 35%, with 2x4 16” on center walls with R-21 fiberglass bass walls, uninsulated salb on grade foundation; vented attic with R-44 blown fiberglass; air to water heat pumps.

  19. Tumor Marker CA 125 in the Diagnosis of Active Pulmonary Tuberculosis - A Study of Adults in Mostar, B&H.

    Science.gov (United States)

    Mikačić, Marijana; Vasilj, Ivan; Vasilj, Marina; Bevanda, Danijel; Šimović, Mario; Galić, Kristina

    2017-12-01

    Tumor marker CA 125 is found in normal mesothelial lung cells and normal bronchial epithelial cells. If destruction of these cells occurs due to inflammation or tumour, CA 125 will be released, and increased in the serum. From November 2008 to May 2009 a study analysing CA 125 levels in serum samples from patients who are hospitalized at the Pulmology Department of University Hospital Mostar. Standard laboratory tests, X-ray, sputum examination to BK, and tumour marker CA 125 were performed in all patients. Patients were divided into 5 groups. Comparing clinical and laboratory findings of patients and statistical processing of collected data, conclusions were drown about the role of tumor markers Ca 125 in the diagnosis of pulmonary tuberculosis. This analysis is performed on 220 patients, forty with pulmonary tuberculosis. Of the total number of patients included, there is 60% of the negative findings of tumor marker Ca 125 which is statistically significant (PCa 125 shows that there is 75% of positive findings in active pulmonary tuberculosis, which is a statistically significant difference (P=0.002). Within the group of patients with lung carcinoma, half of the patients showed positive finding of tumor marker CA 125. Statistical analysis showed that sensitivity of CA 125 was 75%, specificity was (68%) and positive predictive value was 12% in patients with active tuberculosis. The result of this study showed that the increase in serum tumor marker CA 125 is present in active pulmonary tuberculosis as well as in patients with lung cancer.

  20. Pilot study of a culturally adapted psychoeducation (CaPE) intervention for bipolar disorder in Pakistan.

    Science.gov (United States)

    Husain, Muhammad Ishrat; Chaudhry, Imran B; Rahman, Raza R; Hamirani, Munir M; Mehmood, Nasir; Haddad, Peter M; Hodsoll, John; Young, Allan H; Naeem, Farooq; Husain, Nusrat

    2017-12-01

    Despite the use of maintenance medication, recurrence rates in bipolar affective disorder (BPAD) are high. To date, there are no clinical trials that have investigated the use of psychological interventions in bipolar disorder in Pakistan. The purpose of the study was to assess the feasibility and acceptability of a culturally adapted bipolar psychoeducation programme (CaPE) in Pakistan. Thirty-four euthymic bipolar I and II outpatients were randomized to either 12 weekly sessions of individual psychoeducation plus Treatment As Usual (Intervention) or Treatment As Usual (TAU) (Control). Outcomes were assessed using the Young Mania Rating Scale (YMRS), Beck Depression Inventory (BDI), EuroQoL (EQ-5D), Bipolar Knowledge and Attitudes and Questionnaire (BKAQ), and a self-reported measure of medication adherence (Morisky Medication Adherence Scale-4 items, MMAS-4). Effect sizes were derived from baseline adjusted standardized regression coefficients. Retention in the study was good, 80% of patients in the TAU follow-up assessment and 100% of patients in the CaPE group attended all 12 sessions. Patient satisfaction was higher in the CaPE group relative to control (ES = 1.41). Further, there were large effect sizes shown for CaPE versus TAU for medication adherence (MMAS-4: ES = 0.81), knowledge and attitudes towards bipolar (BKAQ: ES = 0.68), mania (YMRS: ES = 1.18), depression (BDI: ES = 1.17) and quality of life measures (EQ-5D: ES ⇒ 0.88). Culturally adapted psychoeducation intervention is acceptable and feasible, and can be effective in improving mood symptoms and knowledge and attitudes to BPAD when compared with TAU. Larger scale studies are needed to confirm our findings. Clinicaltrials.gov identifier NCT02210390.

  1. A receptor tyrosine kinase, UFO/Axl, and other genes isolated by a modified differential display PCR are overexpressed in metastatic prostatic carcinoma cell line DU145.

    Science.gov (United States)

    Jacob, A N; Kalapurakal, J; Davidson, W R; Kandpal, G; Dunson, N; Prashar, Y; Kandpal, R P

    1999-01-01

    We have used a modified differential display PCR protocol for isolating 3' restriction fragments of cDNAs specifically expressed or overexpressed in metastatic prostate carcinoma cell line DU145. Several cDNA fragments were identified that matched to milk fat globule protein, UFO/Axl, a receptor tyrosine kinase, human homologue of a Xenopus maternal transcript, laminin and laminin receptor, human carcinoma-associated antigen, and some expressed sequence tags. The transcript for milk fat globule protein, a marker protein shown to be overexpressed in breast tumors, was elevated in DU145 cells. The expression of UFO/Axl, a receptor tyrosine kinase, was considerably higher in DU145 cells as compared to normal prostate cells and prostatic carcinoma cell line PC-3. The overexpression of UFO oncogene in DU145 cells is discussed in the context of prostate cancer metastasis.

  2. Interactions of Eu(III) with biogenic CaCO{sub 3} studied with TRLFS

    Energy Technology Data Exchange (ETDEWEB)

    Johnstone, Erik V.; Schmidt, Moritz [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Div. Surface Processes; Cherkouk, Andrea [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Div. Biogeochemistry

    2016-07-01

    The interactions of Eu(III) with CaCO{sub 3} arising from biogenic origin was investigated by Time-Resolved Laser-Induced Fluorescence Spectroscopy (TRLFS). Biologically-induced precipitation via ureolysis was studied with the bacteria Sporosarcina pasteurii in the presence of Eu(III). Biomineralization occurred forming mixed phases of vaterite and calcite after one day that transformed over two weeks to pure calcite. Eu(III) was quantitatively removed from solution during mineral formation. TRLFS results show that after one day the Eu{sup 3+} is located in the vaterite phase. After one week, the Eu{sup 3+} was found primarily in the vaterite, despite calcite now being the predominant mineral, and a transition species was also formed. In the calcite two incorporated Eu{sup 3+} species were present: one substitutes at the Ca{sup 2+} site in the crystal lattice and the other is speculated to be associated with the organicmineral matrix.

  3. Chronic Stress Improves NO- and Ca2+ Flux-Dependent Vascular Function: A Pharmacological Study.

    Science.gov (United States)

    Bruder-Nascimento, Thiago; Campos, Dijon Henrique Salome

    2015-01-23

    Background: Stress is associated with cardiovascular diseases. Objective: This study aimed at assessing whether chronic stress induces vascular alterations, and whether these modulations are nitric oxide (NO) and Ca2+ dependent. Methods: Wistar rats, 30 days of age, were separated into 2 groups: control (C) and Stress (St). Chronic stress consisted of immobilization for 1 hour/day, 5 days/week, 15 weeks. Systolic blood pressure was assessed. Vascular studies on aortic rings were performed. Concentration-effect curves were built for noradrenaline, in the presence of L-NAME or prazosin, acetylcholine, sodium nitroprusside and KCl. In addition, Ca2+ flux was also evaluated. Results: Chronic stress induced hypertension, decreased the vascular response to KCl and to noradrenaline, and increased the vascular response to acetylcholine. L-NAME blunted the difference observed in noradrenaline curves. Furthermore, contractile response to Ca2+ was decreased in the aorta of stressed rats. Conclusion: Our data suggest that the vascular response to chronic stress is an adaptation to its deleterious effects, such as hypertension. In addition, this adaptation is NO- and Ca2+-dependent. These data help to clarify the contribution of stress to cardiovascular abnormalities. However, further studies are necessary to better elucidate the mechanisms involved in the cardiovascular dysfunction associated with stressors. (Arq Bras Cardiol. 2014; [online].ahead print, PP.0-0)Fundamento: Estresse está associado com complicações cardiovasculares. Objetivos: O objetivo do presente estudo foi avaliar se o estresse crônico induz alterações vasculares, e se essas alterações são dependentes de óxido nítrico (NO) e Ca2+. Métodos: Ratos machos Wistar com 30 dias de idade foram separados em 2 grupos: controle (C) e Estresse (St). Utilizou-se estresse crônico de imobilização por 1 hora/dia, 5 dias/semana, 15 semanas. Pressão arterial sistólica foi avaliada. A função vascular foi

  4. The Significance of Serum CA-125 Elevation in Chinese Patients with Primary Budd-Chiari Syndrome: A Multicenter Study.

    Science.gov (United States)

    Cheng, De-Lei; Xu, Hao; Lv, Wei-Fu; Hua, Rong; Du, Hongtao; Zhang, Qing-Qiao

    2015-01-01

    Objective. To investigate the serum level of CA-125 and its corresponding clinical significance in Chinese patients with primary BCS. Methods. Serum CA-125 was measured in 243 patients with primary BCS receiving interventional treatment in the participating hospitals and in 120 healthy volunteers. The correlation between serum CA-125 levels and ascites volume, liver function, and prognosis was analyzed. Results. Serum CA-125 was significantly elevated in BCS patients compared to healthy volunteers (P CA-125 were found in BCS patients with abnormal hepatic function and low serum albumin levels and in patients with high volume of ascites compared to patients without these abnormalities. Serum CA-125 levels significantly correlated with ascites volume, serum level of alanine aminotransferase, aspartate aminotransferase, albumin, and Rotterdam BCS scores. The follow-up study indicated that the survival rate and asymptomatic survival rate after interventional treatment were lower in BCS patients with serum CA-125 > 175 U/mL (P CA-125 was significantly higher in patients with primary BCS and had a positive correlation with the volume of ascites, severity of liver damage, and poor prognosis. Thus the serum CA-125 levels may be used to estimate the severity and prognosis of BCS in Chinese patients.

  5. Regulation of the epithelial Ca2+ channels in small intestine as studied by quantitative mRNA detection.

    NARCIS (Netherlands)

    Abel, M. van; Hoenderop, J.G.J.; Kemp, J.W.C.M. van der; Leeuwen, J.P.P.M. van; Bindels, R.J.M.

    2003-01-01

    The epithelial Ca2+ channels TRPV5 and TRPV6 are localized to the brush border membrane of intestinal cells and constitute the postulated rate-limiting entry step of active Ca2+ absorption. The aim of the present study was to investigate the hormonal regulation of these channels. To this end, the

  6. Thermal stability and hot-stage Raman spectroscopic study of Ca-montmorillonite modified with different surfactants: A comparative study

    International Nuclear Information System (INIS)

    Sun, Zhiming; Park, Yuri; Zheng, Shuilin; Ayoko, Godwin A.; Frost, Ray L.

    2013-01-01

    Highlights: • A typical Ca-montmorillonite was modified with three surfactants through ion exchange. • The organoclays were characterized by XRD, TG and hot stage Raman. • The structural geometry and thermal properties of organoclays were analyzed. • The prepared organoclays show potential prospects in the environmental remediation. - Abstract: Three long chain cationic surfactants were intercalated into Ca-montmorillonite through ion exchange and the obtained organoclays were characterized by X-ray diffraction (XRD), high resolution thermogravimetric analysis (TG) and Raman spectroscopy. The intercalation of surfactants not only changes the surface properties of clay from hydrophilic to hydrophobic but also greatly increases the basal spacing of the interlayers based on XRD analysis. The thermal stability of organoclays intercalated with three surfactants (TTAB, DTAB and CTAB) and the different arrangements of the surfactant molecules intercalated into Ca-montmorillonite were determined by TG-DTG analysis. A Raman spectroscopic study on the Ca-montmorillonite modified by three surfactants prepared at different concentrations provided the detailed conformational ordering of different intercalated long-chain surfactants under different conditions. The wavenumber of the antisymmetric stretching mode is more sensitive than that of the symmetric stretching mode to the mobility of the tail of the amine chain. At room temperature, the conformational ordering is more easily affected by the packing density in the lateral model. With the increase of the temperature, the positions of both the antisymmetric and symmetric stretching bands shift to higher wavenumbers, which indicates a decrease of conformational ordering. This study offers new insights into the structure and properties of Ca-montmorillonite modified with different long chain surfactants. Moreover, the experimental results confirm the potential applications of organic Ca-montmorillonites for the removal

  7. Cold K-Ca+ interaction studies in an ion-atom hybrid trap

    Science.gov (United States)

    Saraladevi, Jyothi; Egodapitiya, Kisra; Shu, Gang; Zhang, Bichen; Condoluci, John; Chiappina, Piero; Lao, Di; Jia, Zhubing; Clark, Rob; Brown, Ken

    2017-04-01

    Mixtures of cooled and trapped ions and atoms enable study of cold collisions including elastic collisions, charge exchange interactions and molecular ion formation. To facilitate these studies, we have developed an apparatus comprising a spatially overlapped ion trap (linear Paul trap) and an atom trap (magneto optical trap). The apparatus is integrated with a high resolution time of flight mass spectrometer for identifying the reaction products. Initial studies on interactions between cold Calcium (Ca+) ions and Potassium (K) atoms will be presented. The prospects for rotational cooling of molecular ions by interaction with ultracold Potassium atoms will be discussed. Multidisciplinary University Research Initiative of ARO.

  8. Report of the Second Asian Prostate Cancer (A-CaP Study Meeting

    Directory of Open Access Journals (Sweden)

    Choung-Soo Kim

    2017-09-01

    Full Text Available The Asian Prostate Cancer (A-CaP Study is an Asia-wide initiative that has been developed over the course of 2 years. The study was launched in December 2015 in Tokyo, Japan, and the participating countries and regions engaged in preparations for the study during the course of 2016, including patient registration and creation of databases for the purpose of the study. The Second A-CaP Meeting was held on September 8, 2016 in Seoul, Korea, with the participation of members and collaborators from 12 countries and regions. Under the study, each participating country or region will begin registration of newly diagnosed prostate cancer patients and conduct prognostic investigations. From the data gathered, common research themes will be identified, such as comparisons among Asian countries of background factors in newly diagnosed prostate cancer patients. This is the first Asia-wide study of prostate cancer and has developed from single country research efforts in this field, including in Japan and Korea. At the Second Meeting, participating countries and regions discussed the status of preparations and discussed various issues that are being faced. These issues include technical challenges in creating databases, promoting participation in each country or region, clarifying issues relating to data input, addressing institutional issues such as institutional review board requirements, and the need for dedicated data managers. The meeting was positioned as an opportunity to share information and address outstanding issues prior to the initiation of the study. In addition to A-CaP-specific discussions, a series of special lectures was also delivered as a means of providing international perspectives on the latest developments in prostate cancer and the use of databases and registration studies around the world.

  9. Thermodynamic studies of CaLaFe11O19(s)

    Science.gov (United States)

    Rakshit, S. K.; Parida, S. C.; Lilova, Kristina; Navrotsky, Alexandra

    2013-05-01

    Thermodynamic studies on CaLaFe11O19(s) were carried out using Knudsen effusion mass spectrometry and calorimetry, viz. differential scanning calorimetry and high temperature oxide melt solution calorimetry. Standard molar Gibbs free energy of formation (ΔfG0m), enthalpy of formation and heat capacity (C0p, m) of the compound were calculated as a function of temperature for the first time. C0p, m(CaLaFe11O19) was determined and used for second law analysis, from which enthalpy and entropy of formation of the compound were calculated and the respective values are: ΔfH0m(298.15 K)/kJ mol-1=-6057(±8) and S0m(298.15 K)/J K-1 mol-1=427(±5). ΔfH0m(298.15 K)/kJ mol-1: -6055(±6) was also calculated using oxide melt solution calorimetry, which is in close agreement with the second law value. A heat capacity anomaly was also observed at T=684 K. A table of thermodynamic data from 298.15 K to 1000 K for CaLaFe11O19(s) was also constructed to represent an optimized set of data.

  10. Clinical studies of intestinal /sup 47/Ca absorption test by external arm counter

    Energy Technology Data Exchange (ETDEWEB)

    Ebisuno, Shoichi; Morimoto, Shigeyoshi; Torizumi, Kazutami; Yamada, Ryusaku; Ohta, Kiichiro; Ohkawa, Tadashi

    1984-08-01

    An arm counter used to measure fractional accumulation of /sup 47/Ca on the forearm following an intravenous and a later oral dose of the radioisotope, and the intestinal /sup 47/Ca absorption rate was calculated. Clinical studies were carried out in normal subjects and patients with some disorders of calcium metabolism, using this external counting techinique. In 12 healthy control men (mean age 31.8 y), calcium absorption rate ranged from 42.5% to 59.6%. In 6 healthy women (mean age 31.4 y), the rate ranged from 46.8% to 57.3%. The intestinal calcium absorption was not related to the sex in younger adults. The fractional absorption of calcium was significantly increased in patients with primary hyperparathyroidism, whereas it was reduced in hypoparathyroidism. In 5 female subjects affected by osteoporosis, a defective intestinal absorption of calcium was observed. The calcium absorption tests were carried out on normo- and hypercalciuric patients with calcium urolithiasis. Higher absorption of calcium was recognized in some hypercalciuric patients. In hypercalciuric calcium stone formers with rice-bran treatment, /sup 47/Ca absorption from the gut was decreased significantly.

  11. CaSO4:Dy and/or Tm: study of its properties for dosimetry application

    International Nuclear Information System (INIS)

    Ferreira, M.M.

    1979-01-01

    In order obtain in practical and cheap solid state dosimeter with high sensitivity, a technique initially developed to cold press a mixture of suitable materials in their powder form sensitive to radiation. The material initially used was natural CaF 2 (fluorite) for this salt was extensively studied in radiation dosimetry since it shows a thermoluminescent (TL) effect after radiation. However, natural calcium fluorite shows two main disadvantages: its high senstivity to room light and the impossibility to control its impurity content due to its natural origin. Calcium sulphate was thus used as a good substitute of fluorite. Rare earths doped calcium sulphate shows a high TL sensitivity and is not disturbed by light. It is also easily obtained in the laboratory under controlled conditions so to get reproducible impurity content. The best dosimeters that can be produced with rare earth doped calcium sulphate are CaSO 4 :Dy and CaSO 4 :Tm. Calcium sulphate, simultaneously doped with Tm and Dy was produced and 100% increase was obtained in the TL sensitivity when compared with the individually are earth doped calcium sulphate. (Author) [pt

  12. Theoretical study on the reaction mechanism of CH4 with CaO

    International Nuclear Information System (INIS)

    Yang Huawqing; Hu Changwei; Qin Song

    2006-01-01

    The reaction pathways and energetics for the reaction of methane with CaO are discussed on the singlet spin state potential energy surface at the B3LYP/6-311+G(2df,2p) and QCISD/6-311++G(3df,3pd)//B3LYP/6-311+G(2df,2p) levels of theory. The reaction of methane with CaO is proposed to proceed in the following reaction pathways: CaO + CH 4 → CaOCH 4 → [TS] → CaOH + CH 3 , CaO + CH 4 → OCaCH 4 → [TS] → HOCaCH 3 → CaOH + CH 3 or [TS] → CaCH 3 OH → Ca + CH 3 OH, and OCaCH 4 → [TS] → HCaOCH 3 → CaOCH 3 + H or [TS] → CaCH 3 OH → Ca + CH 3 OH. The gas-phase methane-methanol conversion by CaO is suggested to proceed via two kinds of important reaction intermediates, HOCaCH 3 and HCaOCH 3 , and the reaction pathway via the hydroxy intermediate (HOCaCH 3 ) is energetically more favorable than the other one via the methoxy intermediate (HCaOCH 3 ). The hydroxy intermediate HOCaCH 3 is predicted to be the energetically most preferred configuration in the reaction of CaO + CH 4 . Meanwhile, these three product channels (CaOH + CH 3 , CaOCH 3 + H and Ca + CH 3 OH) are expected to compete with each other, and the formation of methyl radical is the most preferable pathway energetically. On the other hand, the intermediates HCaOCH 3 and HOCaCH 3 are predicted to be the energetically preferred configuration in the reaction of Ca + CH 3 OH, which is precisely the reverse reaction of methane hydroxylation

  13. Study on the diagnostic value of combined determination of serum CA125, CA199 and SIL-2R levels in patients with endometriosis

    International Nuclear Information System (INIS)

    Yang Jingxiu; Shi Shaohong; Wang Yuping; Xie Xueqin; Qin Jibao

    2005-01-01

    Objective: To investigate the diagnostic values of combined determination of serum CA125, CA199 and SIL-2R levels in patients with endometriosis. Methods: Serum CA125, CA199 were measured with RIA and SIL-2R levels with ELISA in 54 patients with endometriosis and 35 controls. Results: The serum levels of CA125, CA199 and SIL-2R in patients with endometriosis were significantly higher than those in controls (P<0.01). The sensitivity and speciality of CA125 for endometriosis was 70.2% and 80.4% respectively, the sensitivity and speciality of CA199 for endometriosis was 62.4% and 71.8% respectively, the sensitivity and speciality of SIL-2R was 89.5% and 60.2% respectively. The sensitivity of the combined determination of CA125, CA199 and SIL-2R for endometriosis was 86.8% being significantly higher than that of CA125 and CA199 respectively. Conclusion: Combined determination of the serum CA125, CA199 and SIL-2R levels in serum can increase the diagnostic sensitivity for endometriosis. (authors)

  14. rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain.

    Science.gov (United States)

    Mark, M R; Scadden, D T; Wang, Z; Gu, Q; Goddard, A; Godowski, P J

    1994-04-08

    We have isolated cDNA clones that encode the human and murine forms of a novel receptor-type tyrosine kinase termed Rse. Sequence analysis indicates that human Rse contains 890 amino acids, with an extracellular region composed of two immunoglobulin-like domains followed by two fibronectin type III domains. Murine Rse contains 880 amino acids and shares 90% amino acid identity with its human counterpart. Rse is structurally similar to the receptor-type tyrosine kinase Axl/Ufo, and the two proteins have 35 and 63% sequence identity in their extracellular and intracellular domains, respectively. To study the synthesis and activation of this putative receptor-type tyrosine kinase, we constructed a version of Rse (termed gD-Rse, where gD represents glycoprotein D) that contains an NH2-terminal epitope tag. NIH3T3 cells were engineered to express gD-Rse, which could be detected at the cell surface by fluorescence-activated cell sorting. Moreover, gD-Rse was rapidly phosphorylated on tyrosine residues upon incubation of the cells with an antibody directed against the epitope tag, suggesting that rse encodes an active tyrosine kinase. In the human tissues we examined, the highest level of expression of rse mRNA was observed in the brain; rse mRNA was also detected in the premegakaryocytopoietic cell lines CMK11-5 and Dami. The gene for rse was localized to human chromosome 15.

  15. Analysis of tumor marker CA 125 in saliva of normal and oral squamous cell carcinoma patients: a comparative study.

    Science.gov (United States)

    Balan, Jude J; Rao, Roopa S; Premalatha, B R; Patil, Shankargouda

    2012-09-01

    The mortality and morbidity associated with oral squamous cell carcinoma (OSCC) can be greatly reduced if tumor markers which can detect OSCC at an early stage are available. The use of saliva as an alternative to blood could provide a substantial advantage in sampling convenience. Cancer antigen 125 (CA 125) is a tumor-associated antigen found to be increased in epithelial tumors like oral, breast and ovarian cancers. To determine whether salivary CA 125 levels are increased significantly in OSCC patients than the control group. Sixty OSCC patients and 60 healthy controls were taken for the study. Saliva samples from both the groups were collected, centrifuged and supernatant fluid were subjected to ELISA for assessment of CA 125. The mean salivary CA 125 values of OSCC patients and control group were statistically analyzed using Mann-Whitney U-test. The mean salivary CA 125 concentration of OSCC group was 320.25 and that of control group was 33.14. Thus, CA 125 was found to be significantly increased in the saliva of OSCC patients than the control group (p < 0.001). Also, there was significant increase in the CA 125 levels as the stage of OSCC increased. The convenience, reliability and noninvasive nature of salivary CA 125 testing makes it a feasible adjunctive diagnostic tool for detection of OSCC.

  16. Ca L2,3-edge XANES and Sr K-edge EXAFS study of hydroxyapatite and fossil bone apatite.

    Science.gov (United States)

    Zougrou, I M; Katsikini, M; Brzhezinskaya, M; Pinakidou, F; Papadopoulou, L; Tsoukala, E; Paloura, E C

    2016-08-01

    Upon burial, the organic and inorganic components of hard tissues such as bone, teeth, and tusks are subjected to various alterations as a result of interactions with the chemical milieu of soil, groundwater, and presence of microorganisms. In this study, simulation of the Ca L 2,3-edge X-ray absorption near edge structure (XANES) spectrum of hydroxyapatite, using the CTM4XAS code, reveals that the different symmetry of the two nonequivalent Ca(1) and Ca(2) sites in the unit cell gives rise to specific spectral features. Moreover, Ca L 2,3-edge XANES spectroscopy is applied in order to assess variations in fossil bone apatite crystallinity due to heavy bacterial alteration and catastrophic mineral dissolution, compared to well-preserved fossil apatite, fresh bone, and geologic apatite reference samples. Fossilization-induced chemical alterations are investigated by means of Ca L 2,3-edge XANES and scanning electron microscopy (SEM) and are related to histological evaluation using optical microscopy images. Finally, the variations in the bonding environment of Sr and its preference for substitution in the Ca(1) or Ca(2) sites upon increasing the Sr/Ca ratio is assessed by Sr K-edge extended X-ray absorption fine structure (EXAFS) spectroscopy.

  17. Environmental change in the Limfjord, Denmark (ca 7500-1500 cal yrs BP): A multiproxy study

    DEFF Research Database (Denmark)

    Lewis, J. P.; Ryves, D.B.; Rasmussen, P.

    2013-01-01

    (and high productivity) between ca 7500–5000 BP, followed by a gradual transition to a shallow benthic system with more oceanic conditions (i.e. higher salinity, lower productivity, slower sedimentary accumulation rate and poorer fossil preservation) after ca 5000 BP and no stratification after ca 4400...

  18. Stamina pistilloida, the Pea ortholog of Fim and UFO, is required for normal development of flowers, inflorescences, and leaves.

    Science.gov (United States)

    Taylor, S; Hofer, J; Murfet, I

    2001-01-01

    Isolation and characterization of two severe alleles at the Stamina pistilloida (Stp) locus reveals that Stp is involved in a wide range of developmental processes in the garden pea. The most severe allele, stp-4, results in flowers consisting almost entirely of sepals and carpels. Production of ectopic secondary flowers in stp-4 plants suggests that Stp is involved in specifying floral meristem identity in pea. The stp mutations also reduce the complexity of the compound pea leaf, and primary inflorescences often terminate prematurely in an aberrant sepaloid flower. In addition, stp mutants were shorter than their wild-type siblings due to a reduction in cell number in their internodes. Fewer cells were also found in the epidermis of the leaf rachis of stp mutants. Examination of the effects of stp-4 in double mutant combinations with af, tl, det, and veg2-2-mutations known to influence leaf, inflorescence, and flower development in pea-suggests that Stp function is independent of these genes. A synergistic interaction between weak mutant alleles at Stp and Uni indicated that these two genes act together, possibly to regulate primordial growth. Molecular analysis revealed that Stp is the pea homolog of the Antirrhinum gene Fimbriata (Fim) and of UNUSUAL FLORAL ORGANS (UFO) from Arabidopsis. Differences between Fim/UFO and Stp mutant phenotypes and expression patterns suggest that expansion of Stp activity into the leaf was an important step during evolution of the compound leaf in the garden pea.

  19. Experimental study on the effect of controlled hypotension levels on rabbit CA1 neurons.

    Science.gov (United States)

    Liu, Bingbing; Zhou, Diawei; Huang, Hongyan; Xiao, Xiaoshan

    2013-06-01

    The present study investigated the effect of controlled hypotension (CH) levels regulated by nitroprusside on hippocampal CA1 neurons. All experimental rabbits were randomly divided into five groups to perform CH for recording their vital signs and survived for a certain time. The arterial blood was collected to measure the serum levels of interleukin 6 and tumor necrosis factor α and then the brain tissues were perfused and sectioned to carry out hematoxylin-eosin staining, TdT-mediated dUTP nick end labeling fluorescence, c-fos immunohistochemistry, and ultrastructural observation of hippocampal neuronal mitochondria. All data were analyzed with SPSS13.0 software, and P < 0.05 was indicated as statistically significant. Heart rate, mean arterial pressure, and the dosage of sodium nitroprusside were not statistically significant between groups, but at T2, heart rate levels in groups II-IV were lower than those in groups I and V. Simultaneously, interleukin 6 was remarkably overexpressed in group II than in other groups at T2, whereas tumor necrosis factor α was higher in groups I-III than in groups IV and V. At the light and electronic microscopic levels, the CA1 regional neurons of group IV were more seriously damaged and deranged compared with other groups so was the expression of c-fos. However, fluorescence from TdT-mediated dUTP nick end labeling assay was more intensive in groups II-IV than that in other groups. Results further showed that Flameng scores of mitochondria were the highest in group IV, but they were not statistically significant among the other groups. The different levels of CH remarkably affected the functional activities of hippocampal CA1 neurons; with the decrease of mean arterial pressure, neuronal apoptosis, and c-fos expression was gradually increased and reached the peak in 45% of basic values of blood pressure. Copyright © 2013 Elsevier Inc. All rights reserved.

  20. Theoretical studies of the paramagnetic perovskites MTaO3 (M = Ca, Sr and Ba)

    International Nuclear Information System (INIS)

    Ali, Zahid; Khan, Imad; Ahmad, Iftikhar; Khan, M. Salman; Asadabadi, S. Jalali

    2015-01-01

    In the present density functional studies, structural, mechanical and magneto-electronic properties of CaTaO 3, SrTaO 3 and BaTaO 3 perovskites have been investigated. The calculated structural parameters by DFT and analytical methods are found consistent with the experiments. The analytically calculated tolerance factors of these compounds as well as their mechanical properties show that they are stable in the cubic phase. Furthermore elastic properties show that these materials are ductile in nature and confirm that BaTaO 3 is harder than the rest compounds. The calculated spin dependent magneto-electronic properties reveal the paramagnetic metallic nature of these compounds. The electrical conductivity curve demonstrates significant conductivity above room temperature. On the basis of the presented properties it is expected that these compounds could be efficient electrode materials and need experimental investigations. - Highlights: • MTaO 3 (M = Ca, Sr and Ba) perovskites are investigated theoretically in the frame work of density functional theory. • Mechanical properties explain the stability of these compounds and show that BaTaO 3 is more ductile. • The magneto-electronic studies reveal the paramagnetic metallic nature of these compounds. • Significant electrical conductivity is observed above room temperature

  1. Structural and thermodynamic studies of the tobacco calmodulin-like rgs-CaM protein.

    Science.gov (United States)

    Makiyama, Rodrigo K; Fernandes, Carlos A H; Dreyer, Thiago R; Moda, Bruno S; Matioli, Fabio F; Fontes, Marcos R M; Maia, Ivan G

    2016-11-01

    The tobacco calmodulin-like protein rgs-CaM is involved in host defense against virus and is reported to possess an associated RNA silencing suppressor activity. Rgs-CaM is also believed to act as an antiviral factor by interacting and targeting viral silencing suppressors for autophagic degradation. Despite these functional data, calcium interplay in the modulation of rgs-CaM is still poorly understood. Here we show that rgs-CaM displays a prevalent alpha-helical conformation and possesses three functional Ca 2+ -binding sites. Using computational modeling and molecular dynamics simulation, we demonstrate that Ca 2+ binding to rgs-CaM triggers expansion of its tertiary structure with reorientation of alpha-helices within the EF-hands. This conformational change leads to the exposure of a large negatively charged region that may be implicated in the electrostatic interactions between rgs-CaM and viral suppressors. Moreover, the k d values obtained for Ca 2+ binding to the three functional sites are not within the affinity range of a typical Ca 2+ sensor. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. Comparison study Irma Ca-125 Kit between the production of immuno tech

    International Nuclear Information System (INIS)

    Puji Widayati; Sri Hartini; Agus Ariyanto

    2012-01-01

    An immunoradiometric assay (IRMA) is one of immunoassay technique using radionuclide as the tracer to detect low quantity of analyte. This technique is based on the reaction between antigen (Ag) contained in the sample or standard (tumor marker) with radioactive antibody (Ab*) which is in the excessive quantity can form the antigen-antibody (Ag-Ab*). This technique is suitable for tumor marker testing in the serum which has complex matrix and various concentration. The tumor marker used for monitoring of ovarium cancer is Ca-125, a kind of antigenic glycoprotein which is formed in the ovarium and released into the blood system of people who suffering ovarium cancer. The aim of this research is to compare between local IRMA Ca-125 kit (produced by Center for Radioisotopes and Radiopharmaceuticals, National Nuclear Energy Agency) and imported IRMA (Immuno tech, France) toward 245 samples obtained from PPTA-BATAN clinic and Dharmais Cancer Hospital. The results showed 184 samples as true negative, 46 samples as true positive of ovarium cancer, 13 samples as false negative and 2 samples as false positive. This comparison study gave diagnostic sensitivity as much as 95.83% and diagnostic specificity as much as 93.40%. (author)

  3. Physical study of CaSO4: Dy thermoluminescence (TL) material

    International Nuclear Information System (INIS)

    Nadira Kamarudin; Wan Saffiey Wan Abdullah; Megat Harun Al Rashid; Nurazila Mat Zali; Hafzaliza Erny Zainal Abidin; Taufik Dollah; Ishak Mansor; Nur Haslinda Ee Abdullah

    2010-01-01

    CaSO 4 : Dy have been prepared with the varies of dopant concentration of 0.1 mol % to 0.5 mol % by wet precipitation technique. The resulting CaSO 4 : Dy powder were characterized using Particle Size Analyzers (PSA) and founded the particle size of the powder are around 4-5 mm with the 91-95 % yield. The morphology of CaSO 4 and determination of dopant was characterized using SEM, TEM and EDX. (author)

  4. Study on the diagnostic value of determination of changes of serum CA125 and CA19-9 levels in patients with endometriosis

    International Nuclear Information System (INIS)

    Liu Aimin

    2008-01-01

    Objective: To explore the diagnostic value of determination of changes of serum CA125 and CA19-9 levels in patients with endometriosis. Methods: Serum CA125 and CA19-9 levels were determined with RIA in 45 patients with endometriosis and 40 controls. Results: Serum levels of CA125 and CA19-9 in patients with endometriosis (89.63 ± 30.16u/ml and 95.62±43.67u/ml respectively) were significantly higher than those (16.26±6.37u/ml and 20.26±8.25u/ml respectively) in controls (P<0. 001). Sensitivity of CA125 for diagnosis of endometriosis was 77.78% and that of CA19-9 was 62.22%, while the specificity was 92.50% and 90.00% respectively. If we only took the patients with both markers elevated as being diagnostically positive, the sensitivity would naturally be lower (57.78%) but the specificity would be 100%. Levels of the markers were significantly higher in stage III, IV patients than those in patients with stage I, II disease (P<0.01). Conclusion: Combined determination of serum CA125 and CA19-9 levels were of highly specific diagnostic value in patients with endometriosis. (authors)

  5. Interfacial phenomena: an in vitro study of the effect of calcium phosphate (Ca-P) ceramic on bone formation.

    Science.gov (United States)

    Hulshoff, J E; van Dijk, K; de Ruijter, J E; Rietveld, F J; Ginsel, L A; Jansen, J A

    1998-06-05

    In previous studies we developed a RF magnetron sputter technique for the production of thin Ca-P coatings. With this technique coatings can be produced that vary in Ca/P ratio as well as in structural appearance. The aim of this investigation was to obtain more understanding of the biological behavior of these coatings by way of in vitro experiments. The effect of noncoated titanium (Ti) and three different Ca-P-sputtered surfaces on the proliferation and differentiation (morphology and matrix production) of osteoblast-like cells was studied. Proliferation was determined using counting procedures; morphology was studied by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Fluorescent markers and energy-dispersive X-ray microanalysis (EDX) were used to obtain quantitative and compositional information about the resultant calcified extracellular matrix (ECM). Results demonstrated that proliferation of the osteoblast-like cells was significantly (p coated samples. On the other hand, more mineralized ECM was formed on the coated surfaces. In addition, TEM confirmed that the cells on the coated substrates were surrounded by ECM with collagen fibers embedded in crystallized, needle-shaped structures. On the basis of these findings, we concluded that: (1) the investigated Ca-P sputter coatings possess the capacity to activate the differentiation and expression of osteogenic cells, and (2) bone formation proceeds faster on Ca-P surfaces than on Ti substrates. Further, this bone-inductive effect appeared to be dependent on the Ca-P ratio of the deposited coatings.

  6. High pressure study of low compressibility tetracalcium aluminum carbonate hydrates 3CaO·Al2O3·CaCO3·11H2O

    KAUST Repository

    Moon, Juhyuk

    2012-01-01

    Synchrotron X-ray diffraction data was collected from a sample of monocarboaluminate 3CaO•Al2O3•CaCO 3•11H2O from ambient pressure to 4.3 GPa. The refined crystal structure at ambient pressure is triclinic with parameters a = 5.77(2) Å, b = 8.47(5) Å, c = 9.93(4) Å, α = 64.6(2)°, β = 82.8(3)°, γ = 81.4(4)°, and space group of P1 or P1̄. It showed some degree of perfectly reversible pressure-induced dehydration with a non-hygroscopic pressure-transmitting medium. However the dehydration effect does not critically affect a bulk modulus due to its strong framework. The isothermal bulk modulus of monocarboaluminate was found to be 53(5) GPa and 54(4) GPa with 3rd order and 2nd order Birch-Murnaghan Equation of state, respectively. That value is higher than for any other reported AFm or AFt phase. The pressure-volume behavior of the monocarboaluminate was compared with that of previous studied hemicarboaluminate. © 2011 Elsevier Ltd. All rights reserved.

  7. Study of the stability of traps in CaSO4:Dy TLD for environment measurements

    International Nuclear Information System (INIS)

    Piaggio-Bonsi, R.; Lorrain, S.; Portal, G.

    1976-01-01

    CaSO 4 : Dy is a highly sensitive TLD material and was chosen for the dosimetry of nuclear plant environment. Since this supervision usually extends over relatively long periods (6 to 12 months) the losses of information of this substance must be reduced as much as possible by promoting the creation of stable traps. To speed up research on the preparation of this material a fast method was developed to determine the half-life of the various traps. This method is based on the Randall and Wilkins model. The decay of the traps is studied for different conservation temperatures of the TLD substance and the half-life of the phenomenon is determined for room temperature by extrapolation. The characteristic energy E and the frequency factor S associated with the trap are determined by the same experiment. The dosimetric peak is due in fact to the TLD effects of two neighbouring levels [fr

  8. Experimental study on fracturing coal seams using CaO demolition materials to improve permeability

    Directory of Open Access Journals (Sweden)

    Yibo Tang

    2017-01-01

    Full Text Available Currently, methane gas disasters in underground coal mines are a major problem which seriously threatens safe mining. This study employed soundless chemical demolition for fracturing coal seams with low permeability. Additionally, the fracturing theory and failure mechanisms of soundless chemical demolition agents were investigated. Materials such as CaO, naphthalene-based water reducer, sodium gluconate and silicate cement were used to prepare the novel soundless chemical demolition agent, whose optimum proportion was discovered to be 90:3:5:7 by carrying out orthogonal experiments. The innovative demolition agent cracked briquettes and the maximum width of cracks reached 16.33 mm, showing significant potential for improving the permeability of coal seams.

  9. Validation studies of the Portuguese experimental version of the Montreal Cognitive Assessment (MoCA): confirmatory factor analysis.

    Science.gov (United States)

    Duro, Diana; Simões, Mário R; Ponciano, Emanuel; Santana, Isabel

    2010-05-01

    The Montreal Cognitive Assessment (MoCA) is a cognitive screening instrument created with the purpose of overcoming some of the insufficiencies of the Mini-Mental State Examination (MMSE). The MoCA evaluates more cognitive areas and is comprised of more complex tasks as compared with the MMSE, which makes it a more sensitive instrument in the detection of Mild Cognitive Impairment (MCI), a state that often progresses to dementia. In this study we performed an analysis of the psychometric and diagnostic properties of the Portuguese experimental version of the MoCA in a clinical sample of 212 subjects with MCI and several dementia subtypes in a memory clinic setting. Additionally, we performed a Confirmatory Factor Analysis (CFA) to assess the MoCA's latent factorial structure. In a clinical population, the MoCA is a valid and reliable instrument with good psychometric properties, revealing high sensitivity in identifying MCI and dementia patients who generally score within the normal range on the MMSE. By using the parcels method, CFA results showed very good/excellent adjustment indexes. The practical implications of this CFA study allow us to propose a two factor model factorial structure for the MoCA: a first factor designated Memory, which includes memory, language and orientation subtests (the latter being closely correlated with the former), and a second factor designated Attention/Executive Functions, comprised of attention, executive functions and visuospacial abilities tasks.

  10. Study on {sup 41}Ca-AMS for diagnosis and assessment of cancer bone metastasis in rats

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Hongtao; Pang, Fangfang [College of Physics and Technology, Guangxi Normal University, Guilin 541004 (China); China Institute of Atomic Energy, P.O. Box 275-50, Beijing 102413 (China); Jiang, Shan; He, Ming; Dong, Kejun; Dou, Liang [China Institute of Atomic Energy, P.O. Box 275-50, Beijing 102413 (China); Pang, Yijun [College of Physics and Technology, Guangxi Normal University, Guilin 541004 (China); China Institute of Atomic Energy, P.O. Box 275-50, Beijing 102413 (China); Yang, Xianlin [College of Physics and Technology, Guangxi Normal University, Guilin 541004 (China); Ruan, Xiangdong [College of Physics, Guangxi University, Nanning 530004 (China); Liu, Manjun; Xia, Chunbo [Guiin Medical University, Guilin 541004 (China)

    2015-10-15

    The annual incidence of new cancer patients in China is about 2 million, 30–40% of which will end up with bone metastasis. Profound study on the preclinical model and early diagnosis of cancer bone metastasis in rats are very significant for the drug development, better understanding and treatment of bone metastases. In order to monitor the process of bone metabolism and early detection of bone metastasis of cancer cells, a technique of {sup 41}Ca isotope tracer combined with AMS has been developed and applied in the study on the bone metastasis of cancer cells by rat model. In this work, 3-month-old female Sprague–Dawley (SD) rats were randomly divided into different groups, and tumor cells injected respectively into the tail vein, femoral artery, femoral cavity and the thigh muscle to establish the rat models for bone metastases. The most appropriate model, i.e., the thigh muscle group, was finally adopted in our real metastases experiment. Each rat in this group was intramuscularly (i.m.) injected with 250 μl CaCl{sub 2} solution (containing 1.4 mg Ca and 5nCi {sup 41}Ca). About 40 days later, the rat mammary gland carcinoma cells (Walker 256) were injected into these rats following the established protocol. After bone metastasis, medicine interventions were performed. The sequential urine and blood samples were collected and analyzed for {sup 41}Ca (by AMS) and N-terminal telopeptide (Ntx), respectively. Bone Mineral Density (BMD) values in the femur and the tibia were measured by CT scan. The results of {sup 41}Ca/Ca in longitudinal urinary samples can sensitively reveal the skeletal perturbations caused by bone metastasis of rats, suggests that {sup 41}Ca might be similarly developed for human use and improve clinical management through the assessment of the curative effect and non-invasive detection of the earliest stages of cancer growth in bone.

  11. Study on the diagnostic values of changes of serum endometrium antibody (EMAb) and CA125 (CA125) levels in patients with endometriosis

    International Nuclear Information System (INIS)

    Yang Jingxiu; Shi Shaohong; Wang Yuping

    2005-01-01

    Objective: To explore the diagnostic values of changes of serum EMAb and CA125 levels in patients with endometriosis. Methods: Serum EMAb levels were measured with ELISA and CA125 levels with RIA in 54 patients with endometriosis and 35 controls. Results: Positive rate of serum EMAb was significantly higher in the patients with endometriosis than those in controls (P≤0.01). Serum CA125 levels were also significantly higher than those in controls (P<0.01). Conclusion: Combined detection of serum EMAb positive rate and CA125 levels was of diagnostic value in patients with endometriosis. (authors)

  12. Study of the Sextans dwarf spheroidal galaxy from the DART Ca II triplet survey

    NARCIS (Netherlands)

    Battaglia, G.; Tolstoy, E.; Helmi, A.; Irwin, M.; Parisi, P.; Hill, V.; Jablonka, P.

    We use Very Large Telescope (VLT)/Fibre Large Array Multi Element Spectrograph (FLAMES) intermediate-resolution (R˜ 6500) spectra of individual red giant branch stars in the near-infrared Ca II triplet (CaT) region to investigate the wide-area metallicity properties and internal kinematics of the

  13. Entorhinal inputs to hippocampal CA1 and dentate gyrus in the rat: a current-source-density study.

    Science.gov (United States)

    Leung, L S; Roth, L; Canning, K J

    1995-06-01

    1. Laminar profiles of the average evoked potentials and current-source-density analysis were used to study the input provided by the medial perforant path (PP) to the hippocampus in the urethan-anesthetized rat. 2. Stimulation of the PP activated an early latency sink in the middle molecular layer of the dentate gyrus (DG) and in the stratum lacunosum-moleculare in CA1. The DG current sink was generated by excitatory synaptic currents activated by the PP on dentate granule cells. In the normal rat, the peak current sink in the DG was typically five times greater than that of CA1. However, the CA1 sink could be distinguished from the DG sink in several ways: 1) it peaked when the DG sink was subsiding; 2) it showed paired-pulse facilitation, whereas the DG sink did not; and 3) in rats in which the DG was lesioned by local colchicine injection, the DG sink was reduced much more than the CA1 sink. 3. The PP afferents to CA1 required a slightly higher stimulus threshold (> 100 microA) for activation than those projecting to the DG granule cells (sink (2.5 +/- 0.2 ms, mean +/- SE) was also slightly longer than that of the DG sink (1.7 +/- 0.1 ms), suggesting that the axons of entorhinal layer III cells that project to CA1 have a slightly lower conduction velocity than the axons of the layer II cells that project to the DG. 4. The short-latency current sink activated by the PP in the distal dendritic layers of CA1 was likely provided by excitatory currents at the distal apical dendrites of CA1 pyramidal cells. The accompanying current source was mainly confined to stratum radiatum and appeared not to involve the cell body layer. Thus the electrotonic current spread may not be effective enough to depolarize the cell body or axon hillock. Contribution of interneurons to the above source-sink profile is possible, with the provision that these interneurons must have dendritic processes that span strata radiatum and lacunosum moleculare. 5. Extracellular field recordings

  14. Study of the OSL response of the CaF2:Dy (TLD-200) dosimeter

    International Nuclear Information System (INIS)

    Medeiros, Beatriz M.; Alencar, Marcus A.V. de

    2013-01-01

    The OSL dosimetry has become, in recent years, a successful technique in personal and environmental dosimetry due to high luminescence efficiency, excellent reproducibility, fast readout of signal and repeated and successive OSL measurements of the same dosimeter. Another factor that contributes to the increased use of OSL dosimetry is the use of the aluminum oxide doped with carbon (Al 2 O 3 :C) as dosimeter. Developed initially as thermoluminescent dosimeter, the Al 2 O 3 :C has an excellent OSL sensitivity, high efficiency, good linearity, low or no fading and excellent stability with respect to environmental conditions. However, the OSL dose response for aluminum oxide is linear only for low doses. For intermediate doses (doses in radiotherapy), the response is supralinear. For the values of high doses used in the processes of food irradiation and sterilization of surgical materials, the OSL signal of the aluminum oxide already saturated. Furthermore, the degree of supralinearity and the saturation value vary from sample to sample (∼ 30-300 Gy). Therefore, the use of aluminum oxide as OSL dosimeter is inappropriate in radiotherapy and in the irradiation industrial processes. The objective of this work is the study of the OSL properties of other dosimetric materials irradiated with values of intermediate and high dose to verify the applicability of the OSL dosimetry in radiotherapy and in the processes of food irradiation and sterilization of medical materials. The dosimetric material used in this work is the calcium fluoride doped with dysprosium (CaF 2 :Dy) produced by Harshaw and known commercially as TLD-200. The results demonstrate that the CaF 2 :Dy has OSL signal and the OSL dose response is linear in the range of 10 Gy to 300 Gy. Therefore, the dosimetry OSL with this dosimeter can be used in the evaluation of doses of the order of dozens to hundreds of grays. (author)

  15. Study of the OSL response of the CaF{sub 2}:Dy (TLD-200) dosimeter

    Energy Technology Data Exchange (ETDEWEB)

    Medeiros, Beatriz M.; Alencar, Marcus A.V. de, E-mail: vallim@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2013-07-01

    The OSL dosimetry has become, in recent years, a successful technique in personal and environmental dosimetry due to high luminescence efficiency, excellent reproducibility, fast readout of signal and repeated and successive OSL measurements of the same dosimeter. Another factor that contributes to the increased use of OSL dosimetry is the use of the aluminum oxide doped with carbon (Al{sub 2}O{sub 3}:C) as dosimeter. Developed initially as thermoluminescent dosimeter, the Al{sub 2}O{sub 3}:C has an excellent OSL sensitivity, high efficiency, good linearity, low or no fading and excellent stability with respect to environmental conditions. However, the OSL dose response for aluminum oxide is linear only for low doses. For intermediate doses (doses in radiotherapy), the response is supralinear. For the values of high doses used in the processes of food irradiation and sterilization of surgical materials, the OSL signal of the aluminum oxide already saturated. Furthermore, the degree of supralinearity and the saturation value vary from sample to sample (∼ 30-300 Gy). Therefore, the use of aluminum oxide as OSL dosimeter is inappropriate in radiotherapy and in the irradiation industrial processes. The objective of this work is the study of the OSL properties of other dosimetric materials irradiated with values of intermediate and high dose to verify the applicability of the OSL dosimetry in radiotherapy and in the processes of food irradiation and sterilization of medical materials. The dosimetric material used in this work is the calcium fluoride doped with dysprosium (CaF{sub 2}:Dy) produced by Harshaw and known commercially as TLD-200. The results demonstrate that the CaF{sub 2}:Dy has OSL signal and the OSL dose response is linear in the range of 10 Gy to 300 Gy. Therefore, the dosimetry OSL with this dosimeter can be used in the evaluation of doses of the order of dozens to hundreds of grays. (author)

  16. Diagnostic value of CA 19-9 in pregnancies complicated by spinal neural tube defects: a preliminary study.

    Science.gov (United States)

    Timur, Hakan; Tokmak, Aytekin; Yucel, Aykan; Ali Inal, Hasan; Buyukkagnici, Umran; Sirvan, Levent; Danisman, Nuri

    2016-01-01

    Various physiological and pathological conditions can induce significant variations in plasma concentrations of tumor markers, such as CA 19-9, which is present in the serum and amniotic fluid of pregnant women. Herein, we aimed to determine the clinical importance of maternal serum CA 19-9 levels in the diagnosis of neural tube defects (NTDs). A total of 100 women were included in this controlled cross-sectional study. Thirty-three patients whose pregnancies were complicated by isolated meningocele or meningomyelocele constituted the study group, whereas 33 normal, healthy pregnant women constituted the control group, and 34 age- and body mass index (BMI)-matched non-pregnant women were chosen for the validation group. The mean maternal serum CA 19-9 levels were 17.2 ± 17.0 IU/mL, 7.1 ± 5.9 IU/mL, and 4.7 ± 3.6 IU/mL in the study, control, and validation groups, respectively (p < 0.001). ROC analyses showed that elevated CA 19-9 values may predict NTDs (p < 0.001). The cut-off value for CA 19-9 was found to be 9.6 IU/mL at 70% (51%-84%, 95% CI) sensitivity and 84% (74%-92%, 95% CI) specificity. CA 19-9 may be a promising noninvasive marker for NTDs. Further studies are needed to reveal the clinical applicability and diagnostic potential of maternal serum CA 19-9 levels in the identification of NTDs.

  17. Dimensionality and magnetic interactions in CaFe2As2: An ab initio study

    International Nuclear Information System (INIS)

    Tompsett, D.A.; Lonzarich, G.G.

    2010-01-01

    We present detailed electronic structure calculations for CaFe 2 As 2 . We investigate in particular the 'collapsed' tetragonal and orthorhombic regions of the temperature-pressure phase diagram and find properties that distinguish CaFe 2 As 2 from other Fe-pnictide compounds. In contrast to the tetragonal phase of other Fe-pnictides the electronic structure in the 'collapsed' tetragonal phase of CaFe 2 As 2 is found to be strongly 3D. By an analysis of the non-interacting susceptibility, χ 0 (q), of CaFe 2 As 2 and LaFePO we discuss the role of magnetic interactions in iron-pnictides. From this we propose an intuitive explanation for the outstanding question relating to why the predicted antiferromagnetic moment depends strongly on coordinate relaxation and the choice of correlation functional.

  18. Structural study of nanosized yttrium-doped CaMnO3 perovskites

    Indian Academy of Sciences (India)

    Administrator

    for solid oxide fuel cells (Raveau et al 1998). It was observed that the substitution of trivalent rare earth cation such as Y3+ for Ca2+ in the parent CaMnO3 compound causes the reduction of Mn4+ to Mn3+ (Nagabhushana et al 2005). Presence of trivalent Mn introduces Jahn–Teller effect and distortion of the coordination ...

  19. Studies on Characterization of Bovine Hydroxyapatite/CaTiO3 Biocomposites

    Directory of Open Access Journals (Sweden)

    Suat Ozturk

    2016-01-01

    Full Text Available Sintering effects and mechanical properties of bovine hydroxyapatite/CaTiO3 composites are investigated for different CaTiO3 ratios. Results indicate that densities of the biocomposites increase while total porosities of those decrease with increasing sintering temperature. Moreover, modulus of elasticity and microhardness increase with increasing sintering temperature. However, values of both toughness and fracture toughness of the biocomposites generally rise with increasing sintering temperature except for 1300°C.

  20. Phosphorylation of the sarcoplasmic reticulum Ca(2+)-ATPase from ATP and ATP analogs studied by infrared spectroscopy.

    Science.gov (United States)

    Liu, Man; Barth, Andreas

    2004-11-26

    Phosphorylation of the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA1a) was studied with time-resolved Fourier transform infrared spectroscopy. ATP and ATP analogs (ITP, 2'- and 3'-dATP) were used to study the effect of the adenine ring and the ribose hydroxyl groups on ATPase phosphorylation. All modifications of ATP altered conformational changes and phosphorylation kinetics. The differences compared with ATP increased in the following order: 3'-dATP > ITP > 2'-dATP. Enzyme phosphorylation with ITP results in larger absorbance changes in the amide I region, indicating larger conformational changes of the Ca(2+)-ATPase. The respective absorbance changes obtained with 3'-dATP are significantly different from the others with different band positions and amplitudes in the amide I region, indicating different conformational changes of the protein backbone. ATPase phosphorylation with 3'-dATP is also much ( approximately 30 times) slower than with ATP. Our results indicate that modifications to functional groups of ATP (the ribose 2'- and 3'-OH and the amino group in the adenine ring) affect gamma-phosphate transfer to the phosphorylation site of the Ca(2+)-ATPase by changing the extent of conformational change and the phosphorylation rate. ADP binding to the ADP-sensitive phosphoenzyme (Ca(2)E1P) stabilizes the closed conformation of Ca(2)E1P.

  1. EPR-TL correlation studies on Bi co-doped CaSO{sub 4}:Dy phosphor

    Energy Technology Data Exchange (ETDEWEB)

    Bakshi, A.K. [Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India); Sanyal, Bhaskar, E-mail: bhaskar_sanyal@rediffmail.co [Food Technology Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India); Joshi, V.J. [Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India); Bhide, M.K.; Natarajan, V. [Radio Chemistry Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India); Sharma, Arun [Food Technology Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India)

    2011-01-15

    CaSO{sub 4}:Dy, CaSO{sub 4}:(Dy, Bi) and CaSO{sub 4}:Bi phosphors were prepared through re-crystallization method. Thermoluminescence (TL) characteristics of these phosphor samples were investigated. The radiation induced radical ions formed in these phosphors were investigated using electron paramagnetic resonance (EPR) spectroscopy. The main signals observed in both CaSO{sub 4}:(Dy, Bi) and CaSO{sub 4}:Bi were identified as SO{sub 4}{sup -} (II), SO{sub 4}{sup -} (-perpendicular ) and SO{sub 3}{sup -} (isotropic) with 'g' values 2.023, 2.0089 and 2.004, respectively. In order to understand the TL mechanism, CaSO{sub 4}:(Dy, Bi) phosphor samples were annealed between 100 and 250 {sup o}C and their EPR spectra were studied. It was observed that EPR signal intensities reduce drastically in 250 {sup o}C annealed phosphor confirming the role of SO{sub 4}{sup -} and SO{sub 3}{sup -} types of defect centers in the dosimetric peak. The reduction in the TL sensitivity with increase in Bi{sup 3+} co-dopant in the phosphor samples was correlated with quenching of TL by Bi{sup 3+} ions rather than the reduction in the concentration of the above defect centers. An effort was also made to use the Bi{sup 3+} co-doped CaSO{sub 4}:Dy phosphor for dosimetry of chilled or frozen food irradiation.

  2. Studies of $\\beta$-delayed two-proton emission : The cases of $^{31}$Ar and $^{35}$Ca

    CERN Multimedia

    Riisager, K; Jokinen, A; Canchel, G; Heinz, A M; Jonson, B N G; Dominguez reyes, R R; Koldste, G T; Fraile prieto, L M; Nilsson, T; Audirac, L L

    2008-01-01

    We propose to perform detailed studies of the decays of the two dripline nuclei $^{31}$Ar and $^{35}$Ca. This will allow an in-depth study in the process of $\\beta$-delayed two-proton emission ($\\beta$2p); as well as provide important information on resonances in $^{30}$S and $^{34}$Ar relevant for the astrophysical rp-process.

  3. A nuclear microscopy study of trace elements Ca, Fe, Zn and Cu in atherosclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Watt, F. [Centre for Ion Beam Applications, Department of Physics, National University of Singapore, Singapore 117542 (Singapore)]. E-mail: phywattf@nus.edu.sg; Rajendran, R. [Centre for Ion Beam Applications, Department of Physics, National University of Singapore, Singapore 117542 (Singapore); Department of Biochemistry, National University of Singapore, Singapore 117542 (Singapore); Ren, M.Q. [Centre for Ion Beam Applications, Department of Physics, National University of Singapore, Singapore 117542 (Singapore); Department of Biochemistry, National University of Singapore, Singapore 117542 (Singapore); Tan, B.K.H. [Department of Pharmacology, National University of Singapore, Singapore 117542 (Singapore); Halliwell, B. [Department of Biochemistry, National University of Singapore, Singapore 117542 (Singapore)

    2006-08-15

    Quantitative mapping of trace elements Ca, Fe, Zn and Cu can be achieved in biological tissue using a nuclear microprobe. Presented here is a brief review of the work we have carried out in the last decade using the nuclear microscope to try and elucidate the role of trace elements Fe, Zn, Cu and Ca in induced atherosclerosis in New Zealand White rabbits fed on a 1% cholesterol diet. The lesions were studied using nuclear microscopy, incorporating a combination of ion beam techniques: particle induced X-ray emission (PIXE), Rutherford backscattering spectrometry (RBS) and scanning transmission ion microscopy (STIM). Iron is present in early lesions at concentrations around seven times higher than the artery wall. Measurements of localized lesion iron concentrations were observed to be highly correlated with the depth of the lesion in the artery wall for each individual animal, implying that local elevated concentrations may provide an accelerated process of atherosclerosis in specific regions of the artery. When the rabbits were kept mildly anaemic, thereby reducing iron levels in the lesion, the progression of the disease was significantly slowed. Iron chelation using desferal showed that early treatment (three weeks into the high fat diet) for relatively long periods (nine weeks) significantly retarded the progression of the disease. Zinc is depleted in the lesion and is also observed to be anti-correlated with local lesion development and feeding the rabbits on a high fat diet with zinc supplements inhibited lesion development, although since no significant increase in lesion zinc levels was measured, this anti-atherosclerotic effect may be indirect. Copper, measured at low levels ({approx}3 ppm) in the early lesion, is also depleted compared to the artery wall, suggesting that it is not a major factor in atherogenesis. Calcium is also depleted in early lesions, although at a later stage mineral deposition (hydroxyapatite) is observed to take place in the lesion

  4. Ca and S K-edge XANES studies of calcite-acid mine water interactions

    Energy Technology Data Exchange (ETDEWEB)

    Myneni, S.C.B.; Perera, R.C.C. [Lawrence Berkeley National Lab., CA (United States)

    1997-04-01

    Heavy metal-rich acidic waters (SO{sub 4}{sup 2{minus}}, AsO{sub 4}{sup 3{minus}}, SeO{sub 4}{sup 2{minus}}, Fe{sup 2+}, Fe{sup 3+}, Al{sup 3+}, Cu{sup 2+}, Zn{sup 2+}, Cd{sup 2+}) and related ochreous coatings are common around abandoned sulfide and coal mine sites. This is mainly caused by the natural weathering of pyrite (FeS{sub 2}), arsenopyrite (FeAsS), and other metal sulfide containing shales. Acid generation in the case of pyrite can be explained by a general reaction: FeS{sub 2} + 3.5 O{sub 2} + H{sub 2}O {leftrightarrow} Fe{sup 2+} + SO{sub 4}{sup 2{minus}} + 2H{sup +}. Also, these low pH waters interact with the soils, and mobilize their soluble elements. One of the common remediation strategies is to allow these acid waters to react with limestone (CaCO{sub 3}-rich rock) and neutralize the pH and precipitate out soluble metals. Yet, the associated problem is the precipitation of Fe and Al oxides and hydroxy sulfate coatings on limestone surfaces, which block calcite reactive sites, and make them ineffective a few hours after initiation of treatment. The main objectives of this research are to examine: (1) the chemistry of limestone surface coatings, and (2) their toxic metal uptake and the conditions that inhibit their formation. Previous molecular studies using X-ray diffraction, and vibrational spectroscopy on limestone surface coatings (sampled from Athens, OH) indicate that the surface-most layer (the layer in contact with water) is composed of schwertmannite (Fe(III)-hydroxy sulfate) like phases. However, white, X-ray amorphous; Al-, sulfate- and carbonate-rich; and Ca-poor phases appeared at the interface between the limestone and the iron oxide coatings. The structure, morphology, and coordination chemistry of component major and trace elements of these white precipitate phases have not previously been examined.

  5. Observed an aerial phenomenon that you can't explain? The UAP Observations Reporting Scheme as a tool for demystifying UFOs and stimulating interest in Science

    Science.gov (United States)

    Ailleris, P.

    2011-10-01

    We present the website's extensive and well illustrated list of misidentifications and describe how people can further check details and develop their knowledge (e.g. satellite paths, stars/planets charts, characteristics of meteors, pictures of sprites, clouds classification). A short illustrated list of cases will be featured, both explained and inexplicable; and outreach activities and partnerships with relevant astronomical projects (e.g. Astronomers without Borders, The World at Night) will be described. We will underline that the project definitely fulfills a need in relation to demystifying UFO events, providing education on pseudo-scientific information, while keeping an attitude of scientific openmindedness. For these reasons, we will encourage the planetary scientists community to further advertise the project's existence and the amateur astronomers and societies who receive questions about UFOs to redirect those queries to the websit.

  6. Study on the serum EMAb, TNF-α, IL-8 and CA-125 levels in patients with endometriosis

    International Nuclear Information System (INIS)

    Hou Shuping; Han Ke

    2006-01-01

    Objective: To study the serum antiendometrium antibody (EMAb), TNF-α, IL-8 and CA-125 levels in patients with endometriosis. Methods: Serum EMAb levels were measured with ELISA and TNF-α, IL-8, CA-125 levels with RIA in 45 patients with histologically proven endometriosis and 35 controls. Results: The positive rate of serum EMAb was significantly higher in the patients with endometriosis than that in controls (P<0.01), Serum TNF-α, IL-8 and CA-125 levels were also significantly higher in the patients than those in controls (P<0.01). Combined measurement of these four markers would yield diagnostic sensitivity and spceificity higher than those from any single marker. In addition, levels of TNF-α, IL-8 and CA-125 in patients with advanced diseases were significantly higher than those in patients with mild diseases. Conclusion: Combined detection of serum EMAb positive rate and TNF-α, IL-8 and CA-125 levels were of clinical diagnostic value in patients with endometriosis. (authors)

  7. Study on the Microstructure, Mechanical Properties and Corrosion Behavior of Mg-Zn-Ca Alloy Wire for Biomaterial Application

    Science.gov (United States)

    Zheng, Maobo; Xu, Guangquan; Liu, Debao; Zhao, Yue; Ning, Baoqun; Chen, Minfang

    2018-03-01

    Due to their excellent biocompatibility and biodegradability, magnesium alloy wires have attracted much attention for biomaterial applications including orthopedic K-wires and sutures in wound closure. In this study, Mg-3Zn-0.2Ca alloy wires were prepared by cold drawing combined with proper intermediate annealing process. Microstructures, texture, mechanical properties and corrosion behavior of Mg-3Zn-0.2Ca alloy wire in a simulated body fluid were investigated. The results showed that the secondary phase and average grain size of the Mg-3Zn-0.2Ca alloy were refined in comparison with the as-extruded alloy and a strong (0002)//DD basal fiber texture system was formed after multi-pass cold drawing. After the annealing, most of the basal planes were tilted to the drawing direction (DD) by about 35°, presenting the characteristics of random texture, and the texture intensity decreased. The as-annealed wire shows good mechanical properties with the ultimate tensile strength (UTS), yield strength (YS) and elongation of 253 ± 8.5 MPa, 212 ± 11.3 MPa and 9.2 ± 0.9%, respectively. Electrochemical and hydrogen evolution measurements showed that the corrosion resistance of the Mg-3Zn-0.2Ca alloy wire was improved after the annealing. The immersion test indicated that the Mg-3Zn-0.2Ca wire exhibited uniform corrosion behavior during the initial period of immersion, but then exhibited local corrosion behavior.

  8. Variable-temperature infrared spectroscopy studies on the thermodynamics of CO adsorption on the zeolite Ca-Y.

    Science.gov (United States)

    Bonelli, Barbara; Areán, Carlos Otero; Armandi, Marco; Rodríguez Delgado, Montserrat; Garrone, Edoardo

    2008-08-25

    Variable temperature FT-IR spectroscopy (in the range of 298-380 K) is used to study the thermodynamics of formation of Ca(2+)...CO carbonyl species upon CO adsorption on the faujasite-type zeolite Ca-Y, and also the (temperature-dependent) isomerization equilibrium between carbonyl and isocarbonyl (Ca(2+)...OC) species. The standard enthalpy and entropy changes involved in formation of the monocarbonyl species resulted to be DeltaH(0)=-50.3 (+/-0.5) kJ mol(-1) and DeltaS(0)=-186 (+/-5) J mol(-1) K(-1), respectively. Isomerization of the (C-bonded) Ca(2+)...CO carbonyl to yield the (O-bonded) Ca(2+)...OC isocarbonyl involves an enthalpy change DeltaH(iso)(0)=+11.4 (+/-1.0) kJ mol(-1). These results are compared with previously reported data for the CO/Sr-Y system; and also, a brief analysis of enthalpy-entropy correlation for CO adsorption on zeolites and metal oxides is given.

  9. Systemic Inflammatory Response Markers and CA-125 Levels in Ovarian Clear Cell Carcinoma: A Two Center Cohort Study.

    Science.gov (United States)

    Kim, Hee Seung; Choi, Hwa-Young; Lee, Maria; Suh, Dong Hoon; Kim, Kidong; No, Jae Hong; Chung, Hyun Hoon; Kim, Yong Beom; Song, Yong Sang

    2016-01-01

    We compared the predictive and prognostic values of leukocyte differential counts, systemic inflammatory (SIR) markers and cancer antigen 125 (CA-125) levels, and identified the most useful marker in patients with ovarian clear cell carcinoma (OCCC). The study included 109 patients with OCCC who did not have any inflammatory conditions except endometriosis, and underwent primary debulking surgery between 1997 and 2012. Leukocyte differential counts (neutrophil, lymphocyte, monocyte, eosinophil, basophil, and platelet), SIR markers including neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), and platelet to lymphocyte ratio (PLR), and CA-125 levels were estimated to select potential markers for clinical outcomes. Among potential markers (neutrophil, monocyte, platelet, NLR, MLR, PLR, and CA-125 levels) selected by stepwise comparison, CA-125 levels were best at predicting advanced stage disease, suboptimal debulking and platinum-resistance (cut-off values, ≥ 46.5, ≥ 11.45, and ≥ 66.4 U/mL; accuracies, 69.4%, 78.7%, and 68.5%) while PLR ≥ 205.4 predicted non-complete response (CR; accuracy, 71.6%) most accurately. Moreover, PLR CA-125 levels may be the most useful marker for predicting advanced-stage disease. Suboptimal debulking and platinum-resistance, and PLR and NLR may be most effective to predict non-CR and PFS in patients with OCCC.

  10. Inverse-kinematics study of 78Kr + 40Ca at 10 AMeV

    Directory of Open Access Journals (Sweden)

    Henry E.

    2015-01-01

    Full Text Available The CHIMERA multi-detector array at LNS Catania has been used to study the inverse-kinematics reaction of 78Kr + 40Ca at a bombarding energy of 10 A MeV. Analysis of the experimental data focused on a class of selected events consistent with the complete fusion and subsequent binary split of the of the reacting system. This class of events features a broad A, Z distribution of fission fragments centered about symmetric fission while exhibiting relative velocities significantly higher than given by Viola systematics. The center-of-mass angular distribution (dσ/dΘ of the fission fragments exhibit an unexpected anisotropy inconsistent with a compound-nucleus reaction and indicates a dynamic fusion-fission like process. The observed angular distribution features an asymmetric forward-backward peaking most prevalent for mass-asymmetric events. Furthermore, the more massive fragment of mass-asymmetric events appears to emerge preferentially in the forward direction, along the beam axis, in analogy to dynamic fragmentation of projectile-like fragments. Analysis of the angular distribution of alpha particles emitted from these fission fragments suggests the events are associated mostly with central collisions.

  11. Study of pulsed laser ablated CaBi 2Ta 2O 9 thin films

    Science.gov (United States)

    Das, Rasmi R.; Pérez, W.; Katiyar, Ram S.; Krupanidhi, S. B.

    2001-07-01

    Polycrystalline CaBi 2Ta 2O 9 thin films were grown on Pt/TiO 2/SiO 2/Si (100) substrates using a pulsed laser deposition technique. The influence of substrate temperature and oxygen pressure on crystallization and orientation of the films was studied. In-situ films deposited under a combination of higher substrate temperature and lower oxygen pressure exhibited a preferred c-axis orientation. Micro-Raman spectroscopy was used for complete understanding of phase evolution of CBT films. Thin films deposited at higher substrate temperatures showed larger grain size and higher surface roughness, observed by atomic force microscopy. The values of maximum polarization (2P m˜13.4 μC/cm 2), remanent polarization (2P r˜4.6 μC/cm 2) and the coercive field E c was about 112 kV/cm obtained for the film deposited at 650°C and annealed at 750°C. The room temperature, dielectric data revealed a dependence on the grain size.

  12. A kinetic study of Ca-containing ions reacting with O, O2, CO2 and H2O: implications for calcium ion chemistry in the upper atmosphere.

    Science.gov (United States)

    Broadley, Sarah; Vondrak, Tomas; Wright, Timothy G; Plane, John M C

    2008-09-14

    A series of gas-phase reactions involving molecular Ca-containing ions was studied by the pulsed laser ablation of a calcite target to produce Ca+ in a fast flow of He, followed by the addition of reagents downstream and detection of ions by quadrupole mass spectrometry. Most of the reactions that were studied are important for describing the chemistry of meteor-ablated calcium in the earth's upper atmosphere. The following rate coefficients were measured: k(CaO+ + O --> Ca+ + O2) = (4.2 +/- 2.8) x 10(-11) at 197 K and (6.3 +/- 3.0) x 10(-11) at 294 K; k(CaO+ + CO --> Ca+ + CO2, 294 K) = (2.8 +/- 1.5) x 10(-10); k(Ca+.CO2 + O2 --> CaO2+ + CO2, 294 K) = (1.2 +/- 0.5) x10(-10); k(Ca+.CO2 + H2O --> Ca+.H2O + CO2) = (13.0 +/- 4.0) x 10(-10); and k(Ca+.H2O + O2 --> CaO2+ + H2O, 294 K) = (4.0 +/- 2.5) x 10(-10) cm3 molecule(-1) s(-1). The quoted uncertainties are a combination of the 1 sigma standard errors in the kinetic data and the systematic errors in the models used to extract the rate coefficients. Rate coefficients were also obtained for the following recombination (also termed association) reactions in He bath gas: k(Ca+.CO2 + CO2 --> Ca+.(CO2)2, 294 K) = (2.6 +/- 1.0) x 10(-29); k(Ca+.H2O + H2O --> Ca+.(H2O)2) = (1.6 +/- 1.1) x 10(-27); and k(CaO2+ + O2 --> CaO2+.O2) high level quantum chemistry calculations and RRKM theory using an inverse Laplace transform solution of the master equation. The surprisingly slow reaction between CaO+ and O was explained using quantum chemistry calculations on the lowest 2A', 2A'' and 4A'' potential energy surfaces. These calculations indicate that reaction mostly occurs on the 2A' surface, leading to production of Ca+ (2S) + O2(1 Delta g). The importance of this reaction for controlling the lifetime of Ca+ in the upper mesosphere and lower thermosphere is then discussed.

  13. Experimental Study Of Precipitation Competition Of Ca(OH)2 And Mg(OH)2 On MSF Desalination Condition

    International Nuclear Information System (INIS)

    Sumijanto

    2001-01-01

    Competition study has been carried out by using sea water simulation containing of 142 on deposit ppm of bicarbonate ion, 400 ppm of calcium ion and 1272 ppm of magnesium ion. Experiment was performed by heating sample at temperature 50, 60, 70, 80, and 90 C for 30 minutes. Precipitation competition of Ca(OHh and Mg(OHh was analyzed by reduction of calcium and magnesium ion. Experiment data showed information that at the temperature bellow 800 o C CaCO 3 precipitation was more dominant, meanwhile above than 80 o C precipitation Mg(OH) 2 was more dominant. This competition occurred because at temperature more than 80 o C rate of hydroxyl ion formation and Mg(OH) 2 recipitation was greater than CaCO 3 precipitation and at temperature bellow 80 o C rate of hydrolysis carbonate ion was less than thermal decomposition bicarbonates ion

  14. Studies of scintillation properties of CaMoO{sub 4} at millikelvin temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, X.; Lin, J.; Kraus, H. [Department of Physics, University of Oxford, Keble Rd., Oxford OX1 3RH (United Kingdom); Mikhailik, V. B., E-mail: vmikhai@hotmail.com [Diamond Light Source, Harwell Science Campus, Didcot OX11 0DE (United Kingdom)

    2015-06-15

    Application of CaMoO{sub 4} as a scintillation target in cryogenic rare event searches relies on the understanding of scintillation properties of the material at the temperatures at which these detectors operate. We devised and implemented a detection module with a low-temperature photomultiplier from Hamamatsu (model R8520-06) powered by a Cockcroft-Walton generator. The detector module containing the CaMoO{sub 4} crystal was placed in a {sup 3}He/{sup 4}He dilution refrigerator and used to measure scintillation characteristics of CaMoO{sub 4} in the millikelvin temperature range. At the lowest temperature achieved, the energy resolution of CaMoO{sub 4} for 122 keV γ from a {sup 57}Co source is found to be 30%, and the fast and slow decay constants are 40.6 ± 0.8 μs and 3410 ± 50 μs, respectively. The temperature variation of the CaMoO{sub 4} decay kinetics is discussed in terms of a three-level model of the emission center.

  15. Electronic properties of CaF sub 2 nanodimensional islands on Si(0 0 1) An MDS and UPS study

    CERN Document Server

    Pasquali, L; Sokolov, N; Selvaggi, G; D'Addato, S; Nannarone, S

    2002-01-01

    The joint use of metastable deexcitation spectroscopy and angle resolved ultraviolet photoemission gives a valuable contribution to the comprehension of the physical-chemical reactions occurring during the formation of an interface between different materials. This approach has been applied to study the evolution of the surface valence band of CaF sub 2 deposited on Si(0 0 1) at different temperatures. Under suitable growth conditions, CaF sub 2 nanostructures of different shape and size can be obtained. Information regarding the chemical reactions taking place within the first deposited layer and the dependence of the electronic properties on film thickness was derived.

  16. Detecting Asymptomatic Recurrence in Early-Stage Endometrial Cancer: The Value of Vaginal Cytology, Imaging Studies, and CA-125.

    Science.gov (United States)

    Lee, Jung-Yun; Kim, Ji Hee; Seo, Jung Won; Kim, Hee Seung; Kim, Jae-Weon; Park, Noh Hyun; Song, Yong-Sang

    2016-10-01

    The aim of this study was to evaluate the value of vaginal cytology, imaging modalities, and serum CA-125 in detecting asymptomatic recurrence during posttreatment surveillance for early-stage endometrial cancer. A retrospective analysis was conducted on patients with stage I to II endometrial cancer who received primary surgical treatment at Seoul National University Hospital between 2000 and 2011. Clinicopathologic characteristics and surveillance test data were obtained from medical records. The total numbers of vaginal cytologies, imaging studies, and serum CA-125 levels performed during surveillance or until recurrence were evaluated, and the number of tests needed to detect each asymptomatic recurrence was calculated. A total of 389 patients were identified, together with a total of 3323 vaginal cytologies, 1025 chest x-rays, 1177 abdominal computed tomography (CT) scans, 98 magnetic resonance imaging scans, 163 positron emission tomography/CT scans, 298 ultrasonographies, and 3335 serum CA-125 results obtained during the surveillance period. Recurrence was detected in 14 patients (3.6%). Ten of these cases were asymptomatic, of which six were identified through CT scans and four were identified through elevated serum CA-125 levels. Most of the patients (7/10) with asymptomatic recurrences had localized recurrence patterns, five of whom underwent curative-intent resection and survived. The number of CA-125 tests needed to identify 1 asymptomatic recurrence was 839, whereas the number of CT scans needed to achieve the same result was 196. Other imaging modalities and vaginal cytology did not detect asymptomatic recurrence. For posttreatment surveillance in early-stage endometrial cancer, vaginal cytology and imaging modalities such as chest x-ray, magnetic resonance imaging, positron emission tomography/CT, and ultrasonography have low utility. Routine CT scans and serum CA-125 testing may be useful for detecting asymptomatic recurrence.

  17. A genetic screen for modifiers of UFO meristem activity identifies three novel FUSED FLORAL ORGANS genes required for early flower development in Arabidopsis.

    Science.gov (United States)

    Levin, J Z; Fletcher, J C; Chen, X; Meyerowitz, E M

    1998-06-01

    In a screen to identify novel genes required for early Arabidopsis flower development, we isolated four independent mutations that enhance the Ufo phenotype toward the production of filamentous structures in place of flowers. The mutants fall into three complementation groups, which we have termed FUSED FLORAL ORGANS (FFO) loci. ffo mutants have specific defects in floral organ separation and/or positioning; thus, the FFO genes identify components of a boundary formation mechanism(s) acting between developing floral organ primordia. FFO1 and FFO3 have specific functions in cauline leaf/stem separation and in first- and third-whorl floral organ separation, with FFO3 likely acting to establish and FFO1 to maintain floral organ boundaries. FFO2 acts at early floral stages to regulate floral organ number and positioning and to control organ separation within and between whorls. Plants doubly mutant for two ffo alleles display additive phenotypes, indicating that the FFO genes may act in separate pathways. Plants doubly mutant for an ffo gene and for ufo, lfy, or clv3 reveal that the FFO genes play roles related to those of UFO and LFY in floral meristem initiation and that FFO2 and FFO3 may act to control cell proliferation late in inflorescence development.

  18. A Preliminary study of Sr/Ca thermometry in Chang Islands, Gulf of Thailand

    Directory of Open Access Journals (Sweden)

    Wararat Sirianansakul

    2014-10-01

    Full Text Available Variations in ratios of strontium-to-calcium (Sr/Ca for two Porites sp. coral specimens collected from Wai (PW and Loa Ya (PLY islands, part of Chang islands, Gulf of Thailand, were determined. Inductively coupled plasma optimal emission spectrometry (ICP-OES was used to analyze this ratio, which demonstrates annual cycles and the data is assumed to reflect the sea surface temperature (SST. Comparing the ratios with SST data, following Sr/Ca–SST relationships were determined PW: Sr/Ca (mmol/mol = 11.56–0.070×SST, PLY: Sr/Ca (mmol/mol = 11.89–0.081×SST. Our correlations are different from those previously reported; a discrepancy that may involve differences in analytical methods employed and abnormally low sea surface salinity (SSS (<30 psu in the Gulf of Thailand.

  19. Voltage clamp methods for the study of membrane currents and SR Ca2+ release in adult skeletal muscle fibres

    Science.gov (United States)

    Hernández-Ochoa, Erick O.; Schneider, Martin F.

    2012-01-01

    Skeletal muscle excitation-contraction (E-C)1 coupling is a process composed of multiple sequential stages, by which an action potential triggers sarcoplasmic reticulum (SR)2 Ca2+ release and subsequent contractile activation. The various steps in the E-C coupling process in skeletal muscle can be studied using different techniques. The simultaneous recordings of sarcolemmal electrical signals and the accompanying elevation in myoplasmic Ca2+, due to depolarization-initiated SR Ca2+ release in skeletal muscle fibres, have been useful to obtain a better understanding of muscle function. In studying the origin and mechanism of voltage dependency of E-C coupling a variety of different techniques have been used to control the voltage in adult skeletal fibres. Pioneering work in muscles isolated from amphibians or crustaceans used microelectrodes or ‘high resistance gap’ techniques to manipulate the voltage in the muscle fibres. The development of the patch clamp technique and its variant, the whole-cell clamp configuration that facilitates the manipulation of the intracellular environment, allowed the use of the voltage clamp techniques in different cell types, including skeletal muscle fibres. The aim of this article is to present an historical perspective of the voltage clamp methods used to study skeletal muscle E-C coupling as well as to describe the current status of using the whole-cell patch clamp technique in studies in which the electrical and Ca2+ signalling properties of mouse skeletal muscle membranes are being investigated. PMID:22306655

  20. Experimental study on the relationship between the mineral production capability and the physiochemical properties in the coproduction of Q phase-3CaO·3Al2O3·CaSO4 cement clinker.

    Science.gov (United States)

    He, Chao; Tian, Chaochao; Li, Gang; Mei, Yahe; Zhang, Quanguo; Jiao, Youzhou

    2018-01-01

    A coproduction tests of quaternary (Q) phase(6CaO·4Al2O3·MgO·SiO2) -3CaO·3Al2O3·CaSO4 cement clinker and an experimental study on the relationship between the mineral production capability and the physiochemical properties are conducted in a two-stage multiphase reaction test bed with Changguang coal. X-ray diffractometer (XRD) analyses are performed on the coproduction clinker samples. The results demonstrate that, with the reduction in particle sizes of the coal powder and the additives and expanded screening level differences between them, both the proportion of Q phase and the mass of 3CaO·3Al2O3·CaSO4 in the clinker increase accordingly. When mixed coal powder particles are prepared through reducing particle sizes and expanding screening level differences between coal powder and additives, the additives CaO and MgO are more likely to be enclosed by coal powder to form globular polymerized particles. In addition, this preparation aids in polymerization and promotes even distribution of CaO, MgO and coal minerals, thus facilitating clinker mineral formation reactions of inorganic substances in the mixed coal powder. Target minerals, such as 2CaO·SiO2 and Q phase, are found in both industrial high-calcium limestone and low-calcium limestone coproduction clinker samples. A diffraction peak of free CaO is also evident in both samples. Compared with a coproduction clinker sample of high-calcium limestone, that of low-calcium limestone exhibits higher diffraction peaks for 2CaO·SiO2 and Q phase. With the current state of the art, it is not yet the optimum choice to substitute CaCO3 for CaO in Q-phase cement clinker coproduction. Before the technology matures and gains practical application, further study on the form and the mixing process of calcium-based additives for cement clinker coproduction will be required.

  1. Culture and Dehydration: A Comparative Study of Caída de la Mollera (Fallen Fontanel) in Three Latino Populations.

    Science.gov (United States)

    Pachter, Lee M; Weller, Susan C; Baer, Roberta D; de Alba Garcia, Javier E Garcia; Glazer, Mark; Trotter, Robert; Klein, Robert E; Gonzalez, Eduardo

    2016-10-01

    A sunken soft-spot or fontanel is a sign for dehydration in infants. Around the world, folk illnesses, such as caída de la mollera in some Latin American cultures, often incorporate this sign as a hallmark of illness, but may or may not incorporate re-hydration therapies in treatment strategies. This report describes a study of lay descriptions of causes, symptoms, and treatments for caída de la mollera in three diverse Latin American populations. A mixed-methods approach was used. Representative community-based samples were interviewed in rural Guatemala, Guadalajara, Mexico, and Edinburgh, Texas, with a 132 item questionnaire on the causes, susceptibility, symptoms, and therapies for caída de la mollera. Cultural consensus analysis was used to estimate community beliefs about caída. Interviews conducted in rural Guatemala (n = 60), urban Mexico (n = 62), and rural Texas on the Mexican border (n = 61) indicated consistency in thematic elements within and among these three diverse communities. The high degree of consistency in the illness explanatory models indicated shared beliefs about caída de la mollera in each of the communities and a core model shared across communities. However, an important aspect of the community beliefs was that rehydration therapies were not widely endorsed. The consistency in explanatory models in such diverse communities, as well as the high degree of recognition and experience with this illness, may facilitate communication between community members, and health care providers/public health intervention planners to increase use of rehydration therapies for caída de la mollera. Recommendations for culturally informed and respectful approaches to clinical communication are provided.

  2. EMP and SIMS studies on Mn/Ca and Fe/Ca systematics in benthic foraminifera from the Peruvian OMZ: a contribution to the identification of potential redox proxies and the impact of cleaning protocols

    OpenAIRE

    Glock, N.; Eisenhauer, A.; Liebetrau, V.; Wiedenbeck, M.; Hensen, C.; Nehrke, G.

    2012-01-01

    In this study we present an initial dataset of Mn/Ca and Fe/Ca ratios in tests of benthic foraminifera from the Peruvian oxygen minimum zone (OMZ) determined with SIMS. These results are a contribution to a better understanding of the proxy potential of these elemental ratios for ambient redox conditions. Foraminiferal tests are often contaminated by diagenetic coatings, like Mn rich carbonate- or Fe and Mn rich (oxyhydr)oxide coatings. Thus, it is substantial to assure that...

  3. A coral Sr/Ca calibration and replication study of two massive corals from the Gulf of Mexico

    Science.gov (United States)

    DeLong, Kristine L.; Flannery, Jennifer A.; Maupin, Christopher R.; Poore, Richard Z.; Quinn, Terrence M.

    2011-01-01

    This study examined the variations in the ratio of strontium-to-calcium (Sr/Ca) for two Atlantic corals (Montastraea faveolata and Siderastrea siderea) from the Dry Tortugas National Park (centered on 24.7°N, 82.8°W) in the Gulf of Mexico. Cores from coral colonies in close proximity (10s of meters) and with the same environmental conditions (i.e., depth and water chemistry) were micro-sampled with approximately monthly resolution and the resulting Sr/Ca variations were calibrated with local sea surface temperature (SST) records. Replication tests for coral Sr/Ca variations found high agreement between intra-colony variations and between individual colonies of S. siderea (a single M. faveolata colony was sampled). Regression analysis of monthly variations in coral Sr/Ca and local SST revealed significant correlation on monthly and inter-annual timescales. Verification of the calibration on different timescales found coral Sr/Ca–SST reconstructions in S. siderea were more accurate than those from M. faveolata, especially on inter-annual timescales. Sr/Ca–SST calibration equations for the two species are significantly different (cf., Sr/Ca = -0.042 SST + 10.070, S. siderea; Sr/Ca = -0.027 SST + 9.893, M. faveolata). Mean linear extension for M. faveolata is approximately twice that of S. siderea (4.63, 4.31, and 8.31 mm year−1, A1, F1, and B3, respectively); however, seasonal Sr/Ca variability in M. faveolata is less than S. siderea (0.323, 0.353, and 0.254 mmol mol−1, A1, F1, and B3, respectively). The reduced slope for M. faveolata is attributed to physical sampling issues associated with complex time-skeletal structure of M. faveolata, i.e., a sampling effect, and not a growth effect since the faster growing M. faveolata has the reduced Sr/Ca variability.

  4. Structural study of nanosized yttrium-doped CaMnO3 perovskites

    Indian Academy of Sciences (India)

    Focus of this research was the structural stability of the yttrium-doped CaMnO3 perovskite phases, which crystallize in orthorhombic space group Pnma. We observed that the unit cell volumes of the investigated compounds increase proportionally with yttrium amount. Furthermore, we investigated the influence of yttrium ...

  5. Structural study of nanosized yttrium-doped CaMnO3 perovskites

    Indian Academy of Sciences (India)

    Administrator

    Structural analysis was ca- rried out using Rietveld refinement and the program Full-. Prof (Rodriguez-Carvajal 1990). Refinement of the crystalline phases obtained under experimental conditions was performed in order to investigate the amount of yttrium incorporated in the structure and its influence on unit cell parameters ...

  6. Mg/Ca partitioning between aqueous solution and aragonite mineral: a molecular dynamics study

    NARCIS (Netherlands)

    Ruiz-Hernandez, S.E.; Grau-Crespo, R.; Almora-Barrios, N.; Wolthers, M.; Ruiz-Salvador, A.R.; Fernandez, N.; Leeuw, N.H. de

    2012-01-01

    We have calculated the concentrations of Mg in the bulk and surfaces of aragonite CaCO3 in equilibrium with aqueous solution, based on molecular dynamics simulations and grand-canonical statistical mechanics. Mg is incorporated in the surfaces, in particular in the (001) terraces,

  7. Structural study of nanosized yttrium-doped CaMnO 3 perovskites

    Indian Academy of Sciences (India)

    Focus of this research was the structural stability of the yttrium-doped CaMnO3 perovskite phases, which crystallize in orthorhombic space group Pnma. We observed that the unit cell volumes of the investigated compounds increase proportionally with yttrium amount. Furthermore, we investigated the influence of yttrium ...

  8. Infrared spectroscopic study of CaFe0.7Co0.3O3

    Science.gov (United States)

    Zhang, C. X.; Xia, H. L.; Dai, Y. M.; Qiu, Z. Y.; Sui, Q. T.; Long, Y. W.; Qiu, X. G.

    2017-08-01

    Temperature-dependent infrared spectroscopy has been investigated for CaFe0.7Co0.3O3 which undergoes a ferromagnetic transition at TC≈177 K . It is observed that the spectral weight is transferred from ˜4800 -14 000 cm-1 to ˜0 -4800 cm-1 as the temperature is lowered around TC. Such a large-range spectral weight transfer is attributed to the Hund's interaction. The phonons in CaFe0.7Co0.3O3 show minor asymmetric line shapes, implying relatively weak electron-phonon coupling compared with the parent compound CaFeO3. The optical conductivity also reveals a broad peak structure in the range of ˜700 -1500 cm-1. Fit by the model of single-polaron absorption, the broad peak is interpreted by the excitation of polarons. From the fitting parameters of the polaron peak, we estimate the electron-phonon coupling constant α ˜ 0.4 -0.5 , implying that CaFe0.7Co0.3O3 falls into the weak-coupling regime.

  9. Integrative spike dynamics of rat CA1 neurons: a multineuronal imaging study.

    Science.gov (United States)

    Sasaki, Takuya; Kimura, Rie; Tsukamoto, Masako; Matsuki, Norio; Ikegaya, Yuji

    2006-07-01

    The brain operates through a coordinated interplay of numerous neurons, yet little is known about the collective behaviour of individual neurons embedded in a huge network. We used large-scale optical recordings to address synaptic integration in hundreds of neurons. In hippocampal slice cultures bolus-loaded with Ca2+ fluorophores, we stimulated the Schaffer collaterals and monitored the aggregate presynaptic activity from the stratum radiatum and individual postsynaptic spikes from the CA1 stratum pyramidale. Single neurons responded to varying synaptic inputs with unreliable spikes, but at the population level, the networks stably output a linear sum of synaptic inputs. Nonetheless, the network activity, even though given constant stimuli, varied from trial to trial. This variation emerged through time-varying recruitment of different neuron subsets, which were shaped by correlated background noise. We also mapped the input-frequency preference in spiking activity and found that the majority of CA1 neurons fired in response to a limited range of presynaptic firing rates (20-40 Hz), acting like a band-pass filter, although a few neurons had high pass-like or low pass-like characteristics. This frequency selectivity depended on phasic inhibitory transmission. Thus, our imaging approach enables the linking of single-cell behaviours to their communal dynamics, and we discovered that, even in a relatively simple CA1 circuit, neurons could be engaged in concordant information processing.

  10. Use of diluted Ca(OH)2 suspensions and their transformation into nanostructured CaCO3 coatings: A case study in strengthening heritage materials (stucco, adobe and stone)

    Science.gov (United States)

    Lanzón, Marcos; Madrid, Juan Antonio; Martínez-Arredondo, Ana; Mónaco, Soledad

    2017-12-01

    In the conservation of heritage materials, the effectiveness of diluted nanolime suspensions in consolidating surfaces is scarcely explored. This paper aims to examine the surface modification of stucco, adobe and stone by deposition of Ca(OH)2 nanoparticles. The nanoparticles were applied in five consecutive coats and transformed into CaCO3 by atmospheric CO2 creating a compatible coating with the surface. The coatings were studied by erosion tests (pull-off tests) and examined by scanning electron microscopy (SEM) and optical microscopy. The tests confirmed the surface resistance was clearly improved due to formation of nanostructured cementing CaCO3 coatings. In addition, the coatings did not practically alter the surface colour due to the diluted nature of the suspensions. To conclude, Ca(OH)2 nanoparticles-based coatings are appropriate solutions to extend the durability of traditional heritage materials, such as stucco, adobe or stone.

  11. Kinetics Study on the Effect of NaCl on the CaSO4 Dissolution Behavior

    Science.gov (United States)

    Song, Jingyao; Shi, Peiyang; Wang, Yeguang; Jiang, Maofa

    2018-01-01

    The study of the dissolution kinetics of CaSO4 is essential for the control of the dissolution and recrystallization behavior of CaSO4. In this work, the kinetic behavior of CaSO4 dissolved in NaCl solution was investigated by means of conductivity meter. The results show that with the increase of concentration of NaCl, the temperature rise and the time prolonged, the dissolution rate of dihydrate CaSO4 gradually increases, and the dissolved apparent activation energy is gradually decreased. When the NaCl concentration is 1.8%, the dissolution kinetic equation is 1-(1-α) 1/3=5.46*10-4exp (-9147/RT) t; When the NaCl concentration is 3.0%, the dissolution kinetic equation is 1-(1-α) 1/3=2.81×10-4 exp (-6753/RT)t; When the NaCl concentration is 3.6%, the dissolution kinetic equation is 1-(1-α) 1/3=3.07×l0-4exp(-6103/RT)t.

  12. Spatial distributions of GABA receptors and local inhibition of Ca2+ transients studied with GABA uncaging in the dendrites of CA1 pyramidal neurons.

    Directory of Open Access Journals (Sweden)

    Yuya Kanemoto

    Full Text Available GABA (γ-amino-butylic acid-mediated inhibition in the dendrites of CA1 pyramidal neurons was characterized by two-photon uncaging of a caged-GABA compound, BCMACM-GABA, and one-photon uncaging of RuBi-GABA in rat hippocampal slice preparations. Although we found that GABA(A-mediated currents were diffusely distributed along the dendrites, currents elicited at the branch points of the apical dendritic trunk were approximately two times larger than those elsewhere in the dendrite. We examined the inhibitory action of the GABA-induced currents on Ca(2+ transients evoked with a single back-propagating action potential (bAP in oblique dendrites. We found that GABA uncaging selectively inhibited the Ca(2+ transients in the region adjacent (20 µm. Our data indicate that GABA inhibition results in spatially confined inhibition of Ca(2+ transients shortly after bAP, and suggest that this effect is particularly potent at the dendritic branch points where GABA receptors cluster.

  13. Measurement of intracellular Ca2+mobilization to study GPCR signal transduction.

    Science.gov (United States)

    Ashokan, Anisha; Aradhyam, Gopala K

    2017-01-01

    Understanding G protein-coupled receptor (GPCR) structure-function relationship and its activation mechanism has been broadly explored using mutational strategy due to problems in GPCR crystallization. Probing into GPCR: effector (G protein/β-arrestin) interactions and downstream signaling are important aspects of GPCR research. Among the G proteins, though there are some approaches to investigate G q -mediated signaling, they involve the use of radioactivity and are qualitative in nature. Our method described here makes use of the cell permeable nature of fluorescent Ca 2+ indicator dye, fura2AM, that binds with the Ca 2+ released in response to GPCR: G q interaction on ligand treatment. Using this spectrophotometric method, EC 50 values of the GPCR: ligand binding can be calculated and the binding affinity can be analyzed. © 2017 Elsevier Inc. All rights reserved.

  14. Theoretical Study of the Structural Phase Transition in RbCaF3

    Science.gov (United States)

    1981-09-01

    definitive knowledge of the po- tential surfaces in the hyperspace of x parameters is a great help in this respect, and can be obtained rela- tively...rapidly. In Fig. 1 we show four unit cells of the perovskite structure, which together define the primitive unit cell of the low-temperature phase...the positions of the Ca2+ and F- ions, respectively. The arrows indicate the low- FIG. 1. Four unit cells of the perovskite structure with arrows at

  15. Studies on Ca2+-Doped CeBr3 Scintillating Materials

    Energy Technology Data Exchange (ETDEWEB)

    Guss, P. [NSTec; Foster, M. E. [SNL; Wong, B. M. [SNL; Doty, F. P. [SNL; Shah, K. [RMD; Squillante, M. [RMD; Glodo, J. [RMD; Yuan, D. [NSTec

    2013-07-03

    Despite the outstanding scintillation performance characteristics of cerium tribromide (CeBr3) and cerium-activated lanthanum tribromide (LaBr3:Ce), their commercial availability and application is limited due to the difficulties of growing large, crack-free single crystals from these fragile materials. The objective of this investigation was to employ aliovalent doping to increase crystal strength while maintaining the optical properties of the crystal. One divalent dopant (Ca2+) was investigated as a dopant to strengthen CeBr3 without negatively impacting scintillation performance. Ingots containing nominal concentrations of 1.9% of the Ca2+ dopant were grown. Preliminary scintillation measurements are presented for this aliovalently doped scintillator. Ca2+-doped CeBr3 exhibited little or no change in the peak fluorescence emission for 371 nm optical excitation for CeBr3. The structural, electronic, and optical properties of CeBr3 crystals were investigated using the density functional theory within generalized gradient approximation. The calculated lattice parameters are in good agreement with the experimental data. The energy band structures and density of states were obtained. The optical properties of CeBr3, including the dielectric function, were calculated.

  16. Orbital ordering in CaV2O4: A neutron scattering study

    Science.gov (United States)

    Pieper, Oliver; Lake, B.; Daoud-Aladine, A.; Reehuis, M.; Perring, T.; Enderle, M.; Rule, K.; Prokes, K.; Klemke, B.; Kiefer, K.; Niazi, A.; Yan, J. Q.; Johnston, D. C.; Honecker, A.

    2010-03-01

    CaV2O4 is a quasi-one dimensional spin-1 Heisenberg antiferromagnet. The magnetism arises from the partially filled t2g-levels of the V^3+-ions, which in addition give an orbital degree of freedom to the system. In contrast to the isovalent vanadium spinel compounds, the low dimensionality in CaV2O4 already arises from the crystal structure. It contains weakly coupled double-chains of edge-sharing VO6 octahedra, where the particular octahedral staggering creates a zigzag-like arrangement of the vanadium ions. This in return gives rise to strong magnetic direct exchange interactions between nearest and next nearest neighbor vanadium ions and to geometrical frustration. However, the strength of the exchange interactions is strongly influenced by the particular occupation of the t2g-orbitals. Depending on the type and degree of octahedral distortion, the system can be interpreted as a frustrated Haldane chain or a spin-1 ladder. Here we use single crystal neutron diffraction and neutron spectroscopy to determine the spin structure as well as the complex excitation spectrum of CaV2O4. The results are analyzed theoretically and from this the leading exchange paths are deduced and discussed in terms of orbital ordering.

  17. Study on intestinal /sup 47/Ca absorption test by employing scintillation camera

    Energy Technology Data Exchange (ETDEWEB)

    Torizumi, K.; Yamada, R.; Ota, K.; Ebisuno, S.

    1987-05-01

    In order to evaluate the clinical application of the calcium absorption test from the intestine, the intestinal /sup 47/Ca absorption test by using a scintillation camera was carried out in our laboratory. The results in the intestinal /sup 47/Ca absorption test using a scintillation camera showed a good correlation to the results which were estimated by using an arm counter previously reported by us. The rate of intestinal /sup 47/Ca absorption in 8 healthy volunteers (5 male, 3 female, average age: 37.6 +- 9.5 years) was 52.0 +- 3.8 %, 74.3 % in a patient with primary hyperparathyroidism 30.4 %, and 32.7 % in two patients with idiopathic hypoparathyroidism respectively. This method is more easily handled and can be performed for only 4 days in institutes that are set up with scintillation camera without any special preparations, and it is recommended to be of clinical usefulness for the diagnosis of calcium metabolic disorders.

  18. A study on intestinal 47Ca absorption test by employing scintillation camera

    International Nuclear Information System (INIS)

    Torizumi, Kazutami; Yamada, Ryusaku; Ota, Kiichiro; Ebisuno, Shoichi

    1987-01-01

    In order to evaluate the clinical application of the calcium absorption test from the intestine, the intestinal 47 Ca absorption test by using a scintillation camera was carried out in our laboratory. The results in the intestinal 47 Ca absorption test using a scintillation camera showed a good correlation to the results which were estimated by using an arm counter previously reported by us. The rate of intestinal 47 Ca absorption in 8 healthy volunteers (5 male, 3 female, average age: 37.6 ± 9.5 years) was 52.0 ± 3.8 %, 74.3 % in a patient with primary hyperparathyroidism 30.4 % and 32.7 % in two patients with idiopathic hypoparathyroidism respectively. This method is more easily handled and can be performed for only 4 days in institutes that are set up with scintillation camera without any special preparations, and it is recommended to be of clinical usefulness for the diagnosis of calcium metabolic disorders. (author)

  19. X-Ray and Neutron Diffraction Study of CaBi 2O 4

    Science.gov (United States)

    Sora, I. Natali; Wong-Ng, W.; Huang, Q.; Roth, R. S.; Rawn, C. J.; Burton, B. P.; Santoro, A.

    1994-04-01

    The crystal structure of the 1:1 CaO-Bi 2O 3 compound (CaBi 2O 4) has been determined by single crystal X-ray and neutron powder diffraction techniques. The compound crystallizes with the symmetry of the monoclinic space group C2/ c and lattice parameters a = 16.6130(5) Å, b = 11.5900(4) Å, c = 13.9939(4) Å, β = 134.048(1)°. The structure consists of sheets parallel to the b-c plane and connected by Ca-O bonds. There is a structural unit in each layer consisting of four Bi atoms, ten oxygen atoms, and two calcium atoms. The Bi atoms are fourfold coordinated and the coordination polyhedron may be described as a short distorted pyramid, open on one end to accommodate the lone-pair electrons of the bismuth atoms. Calcium is seven-coordinated and the coordination polyhedron may be described as a monocapped trigonal prism.

  20. Study of the 249-251Cf + 48Ca reactions: recent results and outlook

    Science.gov (United States)

    Voinov, A. A.; Oganessian, Yu Ts; Abdullin, F. Sh; Brewer, N. T.; Dmitriev, S. N.; Grzywacz, R. K.; Hamilton, J. H.; Itkis, M. G.; Miernik, K.; Polyakov, A. N.; Roberto, J. B.; Rykaczewski, K. P.; Sabelnikov, A. V.; Sagaidak, R. N.; Shirokovsky, I. V.; Shumeiko, M. V.; Stoyer, M. A.; Subbotin, V. G.; Sukhov, A. M.; Tsyganov, Yu S.; Utyonkov, V. K.; Vostokin, G. K.

    2018-02-01

    Experiment aiming at the synthesis of heavy isotopes of Z=118 (Og) using beam of 48Ca and a target of 249-251Cf was undertaken in October 2015 - April 2016 employing the Dubna Gas-Filled Recoil Separator (FLNR JINR). The target of mixed isotopes of 249-251Cf (50.7% of 249Cf, 12.9% of 250Cf, and 36.4% of 251Cf) was irradiated by 48Ca ions at two beam energies of 252 and 258 MeV with the corresponding accumulated beam doses of 1.6×1019 and 1.1×1019. A single event observed at lower beam energy was assigned to the isotope 294Og, the product of the reaction 249Cf(48Ca, 3n); its decay pattern and the observed radioactive properties of the nuclides in the decay chain reproduce in full those observed for 294Og in our earlier experiments of 2002-2005 and 2012. At higher beam energy we observed no decay chains that could be attributed to the isotopes of Og. The possibility of renewal of this experiment in the future is discussed.

  1. Topological organization of CA3-to-CA1 excitation.

    Science.gov (United States)

    Hongo, Yoshie; Ogawa, Koichi; Takahara, Yuji; Takasu, Keiko; Royer, Sebastien; Hasegawa, Minoru; Sakaguchi, Gaku; Ikegaya, Yuji

    2015-09-01

    The CA1-projecting axons of CA3 pyramidal cells, called Schaffer collaterals, constitute one of the major information flow routes in the hippocampal formation. Recent anatomical studies have revealed the non-random structural connectivity between CA3 and CA1, but little is known regarding the functional connectivity (i.e. how CA3 network activity is functionally transmitted downstream to the CA1 network). Using functional multi-neuron calcium imaging of rat hippocampal slices, we monitored the spatiotemporal patterns of spontaneous CA3 and CA1 burst activity under pharmacological GABAergic blockade. We found that spatially clustered CA3 activity patterns were transformed into layered CA1 activity sequences. Specifically, synchronized bursts initiated from multiple hot spots in CA3 ensembles, and CA1 neurons located deeper in the pyramidal cell layer were recruited during earlier phases of the burst events. The order of these sequential activations was maintained across the bursts, but the sequence velocity varied depending on the inter-burst intervals. Thus, CA3 axons innervate CA1 neurons in a highly topographical fashion. © 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  2. Time Capture Tool (TimeCaT): development of a comprehensive application to support data capture for Time Motion Studies.

    Science.gov (United States)

    Lopetegui, Marcelo; Yen, Po-Yin; Lai, Albert M; Embi, Peter J; Payne, Philip R O

    2012-01-01

    Time Motion Studies (TMS) have proved to be the gold standard method to measure and quantify clinical workflow, and have been widely used to assess the impact of health information systems implementation. Although there are tools available to conduct TMS, they provide different approaches for multitasking, interruptions, inter-observer reliability assessment and task taxonomy, making results across studies not comparable. We postulate that a significant contributing factor towards the standardization and spread of TMS would be the availability and spread of an accessible, scalable and dynamic tool. We present the development of a comprehensive Time Capture Tool (TimeCaT): a web application developed to support data capture for TMS. Ongoing and continuous development of TimeCaT includes the development and validation of a realistic inter-observer reliability scoring algorithm, the creation of an online clinical tasks ontology, and a novel quantitative workflow comparison method.

  3. PIK3CA

    Science.gov (United States)

    Ilic, Nina; Birsoy, Kıvanç; Aguirre, Andrew J; Kory, Nora; Pacold, Michael E; Singh, Shambhavi; Moody, Susan E; DeAngelo, Joseph D; Spardy, Nicole A; Freinkman, Elizaveta; Weir, Barbara A; Tsherniak, Aviad; Cowley, Glenn S; Root, David E; Asara, John M; Vazquez, Francisca; Widlund, Hans R; Sabatini, David M; Hahn, William C

    2017-04-25

    Oncogenic PIK3CA mutations are found in a significant fraction of human cancers, but therapeutic inhibition of PI3K has only shown limited success in clinical trials. To understand how mutant PIK3CA contributes to cancer cell proliferation, we used genome scale loss-of-function screening in a large number of genomically annotated cancer cell lines. As expected, we found that PIK3CA mutant cancer cells require PIK3CA but also require the expression of the TCA cycle enzyme 2-oxoglutarate dehydrogenase (OGDH). To understand the relationship between oncogenic PIK3CA and OGDH function, we interrogated metabolic requirements and found an increased reliance on glucose metabolism to sustain PIK3CA mutant cell proliferation. Functional metabolic studies revealed that OGDH suppression increased levels of the metabolite 2-oxoglutarate (2OG). We found that this increase in 2OG levels, either by OGDH suppression or exogenous 2OG treatment, resulted in aspartate depletion that was specifically manifested as auxotrophy within PIK3CA mutant cells. Reduced levels of aspartate deregulated the malate-aspartate shuttle, which is important for cytoplasmic NAD + regeneration that sustains rapid glucose breakdown through glycolysis. Consequently, because PIK3CA mutant cells exhibit a profound reliance on glucose metabolism, malate-aspartate shuttle deregulation leads to a specific proliferative block due to the inability to maintain NAD + /NADH homeostasis. Together these observations define a precise metabolic vulnerability imposed by a recurrently mutated oncogene.

  4. TNP-AMP Binding to the Sarcoplasmic Reticulum Ca2+-ATPase Studied by Infrared Spectroscopy

    OpenAIRE

    Liu, Man; Barth, Andreas

    2003-01-01

    Infrared spectroscopy was used to monitor the conformational change of 2′,3′-O-(2,4,6-trinitrophenyl)adenosine 5′-monophosphate (TNP-AMP) binding to the sarcoplasmic reticulum Ca2+-ATPase. TNP-AMP binding was observed in a competition experiment: TNP-AMP is initially bound to the ATPase but is then replaced by β,γ-iminoadenosine 5′-triphosphate (AMPPNP) after AMPPNP release from P3-1-(2-nitrophenyl)ethyl AMPPNP (caged AMPPNP). The resulting infrared difference spectra are compared to those of...

  5. Ab initio study of the low-lying electronic states of the CaO molecule

    Energy Technology Data Exchange (ETDEWEB)

    Khalil, Hossain; Brites, Vincent; Quere, Frederic Le [Universite Paris-Est, Laboratoire de Modelisation et Simulation Multi Echelle, UMR 8208 CNRS, Batiment Lavoisier, 5 boulevard Descartes, Champs sur Marne, 77454 Marne-la-Vallee, Cedex 2 (France); Leonard, Celine, E-mail: celine.leonard@univ-paris-est.fr [Universite Paris-Est, Laboratoire de Modelisation et Simulation Multi Echelle, UMR 8208 CNRS, Batiment Lavoisier, 5 boulevard Descartes, Champs sur Marne, 77454 Marne-la-Vallee, Cedex 2 (France)

    2011-07-28

    Graphical abstract: Highly correlated ab initio calculations have been performed for an accurate determination of the electronic structure of the low-lying electronic states of the CaO molecule. The computations are done using the aug-cc-pV5Z basis set for O and the cc-pCV5Z for Ca. The potential energy curves for the molecular states correlating to the lowest three asymptotes are calculated at the CASSCF level. The potential curves of the lowest five molecular states, X{sup 1}{Sigma}{sup +}, a{sup 3}{Pi}, A'{sup 1{Pi}}, b{sup 3}{Sigma}{sup +} and A{sup 1}{Sigma}{sup +}, and the corresponding dipole moment functions have been determined using internally contracted multi-reference configuration interaction approaches. The spectroscopic constants associated with these electronic states are compared to experimental values. The corresponding electronic wavefunctions have also been analyzed using the dipole moment functions. Display Omitted Highlights: {yields} The five lowest electronic states of Cao have been determined ab initio at a high level of accuracy. {yields} Large active space, core-valence correlation and configuration interaction are required. {yields} The multi-configurational nature of the electronic ground state is confirmed as well as its monovalent and divalent ionic nature using dipole moment analysis. {yields} These interacting potentials will serve for future obtention of spin-rovibronic levels. - Abstract: Highly correlated ab initio calculations have been performed for an accurate determination of the electronic structure of the low-lying electronic states of the CaO molecule. The computations are done using the aug-cc-pV5Z basis set for O and the cc-pCV5Z for Ca. The potential energy curves for the molecular states correlating to the lowest three asymptotes are calculated at the CASSCF level. The potential curves of the lowest five molecular states, X{sup 1}{Sigma}{sup +}, a{sup 3}{Pi}, A'{sup 1}{Pi}, b{sup 3}{Sigma}{sup +} and A{sup 1

  6. Electronic structure and lattice dynamics of CaPd3B studied by first-principles methods

    International Nuclear Information System (INIS)

    Music, Denis; Ahuja, Rajeev; Schneider, Jochen M.

    2006-01-01

    Using first-principles methods, we have studied the electronic structure and lattice dynamics of CaPd 3 B and compared them to isostructural MgNi 3 C. CaPd 3 B possesses less electronic states at the Fermi level, but more phonon modes at low frequencies, than MgNi 3 C. According to the phonon density of states, low frequency acoustic modes are dominated by Pd states, corresponding to Ni in MgNi 3 C. Furthermore, these Pd modes show soft phonons, which may be significant for second-order phase transitions. Based on the comparison to MgNi 3 C, we suggest that the properties of these two compounds may be similar

  7. Angle-resolved photoemission studies of lattice polaron formation in the cuprate Ca2CuO2Cl2

    Energy Technology Data Exchange (ETDEWEB)

    Shen, K.M.

    2010-05-03

    To elucidate the nature of the single-particle excitations in the undoped parent cuprates, we have performed a detailed study of Ca{sub 2}CuO{sub 2}Cl{sub 2} using photoemission spectroscopy. The photoemission lineshapes of the lower Hubbard band are found to be well-described by a polaron model. By comparing the lineshape and temperature dependence of the lower Hubbard band with additional O 2p and Ca 3p states, we conclude that the dominant broadening mechanism arises from the interaction between the photohole and the lattice. The strength of this interaction was observed to be strongly anisotropic and may have important implications for the momentum dependence of the first doped hole states.

  8. Ultrasonic study of structural instability of monocrystalline and polycrystalline Bi-Sr-Ca-Cu-O

    International Nuclear Information System (INIS)

    Wang, Yening; Wu, Jin; Shen, Huimin; Zhu, Jinsong; Chen, Xiaohua; Yan, Yifeng; Zhao, Zhongxian

    1990-01-01

    Two internal-friction (attenuation) peaks around 95 and 130 K in the polycrystal and single crystal of Bi-Sr-Ca-Cu-O are found to be related to the superconducting transition at 84 and 107 K, respectively. The jump of lattice parameter and shape-memory effect occurring at the peak temperatures reveal the characteristics of a martensitic transition. The velocity and attenuation versus temperature of ultrasonic longitudinal waves propagating along two directions in the a-b plane at 10 degree to the a and b axes and of [010] shear waves with [100] polarization were measured for the Bi 2 Sr 2 CaCu 2 O 8 single crystals. The anisotropic elasticity in the c plane is manifested. Only the longitudinal waves in a direction and the shear waves show an obvious softening minimum of velocity around 250 K, which is associated with an attenuation peak due to a phaselike transition, but other longitudinal waves reveal a monotonic stiffening from room temperature down to T c . The origin of the overall trend of elastic stiffening that appears in the measurements so far for high-T c oxides is discussed

  9. Comparative study of the ionic exchange of Ca++, Sr++, and Ba++ cations on resins and inorganic exchangers

    International Nuclear Information System (INIS)

    Sanchez Batanero, P.

    1969-03-01

    With a view to applying the results to certain problems related to chemical separations in activation analysis, a study has been made, of the possibilities of separating the alkaline-earth elements Ca, Sr and Ba on organic resins and inorganic exchangers using the radioactive indicator method. The partition coefficients of the cations Ca 2+ , Sr 2+ and Ba 2+ have been measured on Dowex 50 W (NH 4 + ) x 8 resin in the presence of EDTA - NTA - EGTA and DCTA as complexing agents, and on zirconium phosphate, tungstate and molybdate in the presence of HCl and NH 4 Cl. Methods have been developed for separating mixtures of alkaline-earth elements using DCTA-NH 4 + followed by elution on Dowex 50 W (NH 4 + ) x 8 resin columns and on zirconium phosphate. Amongst the complexing agents used on the ion-exchange resins the most promising appears to be DCTA which leads to partition coefficients Ca, Sr and Ba which are very different. The results of measurements of partition coefficients on zirconium phosphate (NH 4 + form) using DCTA-NH 4 + show the interesting possibilities of separations on columns. The separation of the alkaline-earth elements on zirconium phosphate seems to be less quantitative than on Dowex 50 resin; it is however much faster in the former case and this can be useful for treating short half-life radioisotopes in activation analysis. (author) [fr

  10. Magnetic fluctuations and superconducting properties of CaKFe4As4 studied by 75As NMR

    Science.gov (United States)

    Cui, J.; Ding, Q.-P.; Meier, W. R.; Böhmer, A. E.; Kong, T.; Borisov, V.; Lee, Y.; Bud'ko, S. L.; Valentí, R.; Canfield, P. C.; Furukawa, Y.

    2017-09-01

    We report 75As nuclear magnetic resonance (NMR) studies on a new iron-based superconductor, CaKFe4As4 , with Tc=35 K. 75As NMR spectra show two distinct lines corresponding to the As(1) and As(2) sites close to the K and Ca layers, respectively, revealing that K and Ca layers are well ordered without site inversions. We found that nuclear quadrupole frequencies νQ of the As(1) and As(2) sites show an opposite temperature T dependence. Nearly T independent behavior of the Knight shifts K is observed in the normal state, and a sudden decrease in K in the superconducting (SC) state suggests spin-singlet Cooper pairs. 75As spin-lattice relaxation rates 1 /T1 show a power-law T dependence with different exponents for the two As sites. The isotropic antiferromagnetic spin fluctuations characterized by the wave vector q =(π ,0 ) or (0 ,π ) in the single-iron Brillouin zone notation are revealed by 1 /T1T and K measurements. Such magnetic fluctuations are necessary to explain the observed temperature dependence of the 75As quadrupole frequencies, as evidenced by our first-principles calculations. In the SC state, 1 /T1 shows a rapid decrease below Tc without a Hebel-Slichter peak and decreases exponentially at low T , consistent with an s± nodeless two-gap superconductor.

  11. Age-dependent decrease in the activity of succinic dehydrogenase in rat CA1 pyramidal cells: a quantitative cytochemical study.

    Science.gov (United States)

    Bertoni-Freddari, C; Fattoretti, P; Caselli, U; Paoloni, R; Meier-Ruge, W

    1996-09-09

    A computer-assisted morphometric study has been carried out on the ultrastructure of perikaryal CA1 pyramidal cell mitochondria positive to the copper ferricyanide cytochemical reaction for succinic dehydrogenase (SDH) in rats of 3, 12 and 23 months of age. The cytoplasmic volume fraction occupied by the positive mitochondria (Volume density: Vv), the number of organelles/micron 3 of CA1 pyramidal cell cytoplasm (Numerical density: Nv) and the average mitochondrial volume (V) were automatically calculated by means of computer-assisted morphometry. Vv was significantly decreased in 23-month-old animals versus the other age groups. Nv was unchanged between 3 and 12 months of age, but was decreased to a significant extent in old animals. V did not undergo significant changes in the three age groups taken into account. In the old animals the percent of organelles smaller than 0.16 micron 3 is above 20%, while in the young and adult groups the same size of mitochondria accounts for 7 and 3%, respectively. Thus, a reduction in the number of medium sized organelles appears to be responsible for the decrease in Vv due to age. Since SDH activity is known to support maximum rates of respiration, quantitative estimation of the active mitochondria provides information on the metabolic competence of the cells investigated when energy demand is high. In this context, our present findings document that a significant impairment in the efficiency to match actual energy provisions occurs in old CA1 pyramidal cells.

  12. An in vitro study on the cytotoxicity of bismuth oxychloride nanosheets in human HaCaT keratinocytes.

    Science.gov (United States)

    Gao, Xiaoya; Zhang, Xiaochao; Wang, Yawen; Wang, Yunfang; Peng, Shiqi; Fan, Caimei

    2015-06-01

    As an emerging nanomaterial, bismuth oxychloride (BiOCl) has attracted explosive interests in diverse areas. However, how it interfaces with biological systems, particularly its interaction with human cells and the resulting effects are completely unknown. In this paper, the cytotoxicity of BiOCl nanosheets (NSs) was investigated toward a human skin derived cell line (HaCaT). It was found that BiOCl-NSs had no cytotoxicity at low concentrations (<0.5 µg/mL), whereas higher concentrations (5-100 µg/mL) of BiOCl-NSs could trigger toxic effects on HaCaT cells, with changes in cell morphology and impairment of intracellular structures (mitochondria and cytoskeleton). BiOCl-NSs also led to cell apoptosis and cells cycle arrest in G0/G1 phase. Flow cytometric data showed that BiOCl-NSs were effectively incorporated into HaCaT cells. Transmission electron microscope (TEM) images further revealed that BiOCl-NSs sequestered in the lysosomes, mitochondria, nuclei, and vesicles. Results of DCFH-DA assay and nutritional antioxidant N-acetylcysteine (NAC) experiments suggested that an oxidative stress mechanism was involved in the cytotoxic effects of BiOCl-NSs. Taken together, this work represents the first study on the behavior of BiOCl-NSs on human cells, and constitutes the first and essential step for the risk assessment of BiOCl nanomaterials. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Synthesis, bioactivity and preliminary biocompatibility studies of glasses in the system CaO-MgO-SiO2-Na2O-P2O5-CaF2.

    Science.gov (United States)

    Tulyaganov, D U; Agathopoulos, S; Valerio, P; Balamurugan, A; Saranti, A; Karakassides, M A; Ferreira, J M F

    2011-02-01

    New compositions of bioactive glasses are proposed in the CaO-MgO-SiO(2)-Na(2)O-P(2)O(5)-CaF(2) system. Mineralization tests with immersion of the investigated glasses in simulated body fluid (SBF) at 37°C showed that the glasses favour the surface formation of hydroxyapatite (HA) from the early stages of the experiments. In the case of daily renewable SBF, monetite (CaHPO(4)) formation competed with the formation of HA. The influence of structural features of the glasses on their mineralization (bioactivity) performance is discussed. Preliminary in vitro experiments with osteoblasts' cell-cultures showed that the glasses are biocompatible and there is no evidence of toxicity. Sintering and devitrification studies of glass powder compacts were also performed. Glass-ceramics with attractive properties were obtained after heat treatment of the glasses at relatively low temperatures (up to 850°C).

  14. Study of solid state interactions in the systems ZnFe2O4 - CaO, ZnFe2O4 - MgO and zinc cake with CaO and MgO

    Directory of Open Access Journals (Sweden)

    Peltekov A.B.

    2013-01-01

    Full Text Available The solid state interactions of CaO and MgO with synthetic and industrial ZnFe2O4 (in zinc cake have been studied using chemical, XRD analysis and Mössbauer spectroscopy. The exchange reactions in the systems ZnFe2O4 - CaO and ZnFe2O4 - MgO have been investigated in the range of 850-1200ºC and duration up to 180 min. It has been established that Ca2+ and Mg2+ ions exchange Zn2+ in ferrite partially and the solubility of zinc in a 7% sulfuric acid solution increases. The possibilities for utilization of the obtained results in zinc hydrometallurgy have been discussed.

  15. Photoluminescence study of Tb3+ doped CaCO3 synthesized by solid state metathesis

    Science.gov (United States)

    Muke, A. M.; Ugemuge, N. S.; Moharil, S. V.

    2016-05-01

    Conventional solid-state reaction or simple solution precipitation techniques suffer from several limitations, i.e. a high processing temperature, relatively high preparation cost and more time of preparation, highly complicated synthesis, in-stoichiometric compositions and poor crystallinity. Preparation of inorganic phosphors by microwave assisted Solid state metathesis is one of the superior methods of synthesis. Time duration required for synthesis by microwave assisted synthesis is relatively low. The required reaction temperature can be attempted using domestic microwave oven with consumption of relatively low energy. CaCO3 is one of the most abundant biological minerals in nature and has found many important applications in industry, such as pigments, paper makings, plastics, rubbers, and so on.

  16. Ab Initio Study of 40Ca with an Importance Truncated No-Core Shell Model

    Energy Technology Data Exchange (ETDEWEB)

    Roth, R; Navratil, P

    2007-05-22

    We propose an importance truncation scheme for the no-core shell model, which enables converged calculations for nuclei well beyond the p-shell. It is based on an a priori measure for the importance of individual basis states constructed by means of many-body perturbation theory. Only the physically relevant states of the no-core model space are considered, which leads to a dramatic reduction of the basis dimension. We analyze the validity and efficiency of this truncation scheme using different realistic nucleon-nucleon interactions and compare to conventional no-core shell model calculations for {sup 4}He and {sup 16}O. Then, we present the first converged calculations for the ground state of {sup 40}Ca within no-core model spaces including up to 16{h_bar}{Omega}-excitations using realistic low-momentum interactions. The scheme is universal and can be easily applied to other quantum many-body problems.

  17. Study of phase equilibria and glass formation in the CaO-WO3-P2O5 system

    International Nuclear Information System (INIS)

    Bielis, I.Ya.

    1980-01-01

    The method of quenching has been used to investigate the liquidus surface of a portion of the CaO-WO 3 -P 2 O 5 system limited by the Ca(PO 3 ) 2 -W 2 O 3 (PO 4 ) 2 and CaWO 4 -Ca 2 P 2 O 7 cross-sections. The primary crystallization fields on the compounds: WO 3 , W 2 O 3 (PO 4 ) 2 , CaWO 4 , Ca 2 P 7 O 7 , Ca(PO 3 ) 2 are separated. The liquidus surface isotherms at 900, 1000, 1100 and 1200 deg C have been plotted on the concentration triangle plane. It has been found that the cross-sections of W 2 O 3 (PO 4 ) 2 -Ca(PO 3 ) 2 , WO 3 -Ca(PO 3 ) 2 , WO 3 -Ca 2 P 2 O 7 and CaWO 4 -Ca 2 P 2 O 7 are eutectic-type quasi-binary systems. The position of the glass transition region in the CaO-WO 3 -P 2 O 5 system has been determined for the treatment temperatures of 1100, 1200 and 1300 deg C and a correlation between the configuration of the glass transition region and the phase diagram of the system has been demonstrated [ru

  18. Ca2+ current versus Ca2+ channel cooperativity of exocytosis.

    Science.gov (United States)

    Matveev, Victor; Bertram, Richard; Sherman, Arthur

    2009-09-30

    Recently there has been significant interest and progress in the study of spatiotemporal dynamics of Ca(2+) that triggers exocytosis at a fast chemical synapse, which requires understanding the contribution of individual calcium channels to the release of a single vesicle. Experimental protocols provide insight into this question by probing the sensitivity of exocytosis to Ca(2+) influx. While varying extracellular or intracellular Ca(2+) concentration assesses the intrinsic biochemical Ca(2+) cooperativity of neurotransmitter release, varying the number of open Ca(2+) channels using pharmacological channel block or the tail current titration probes the cooperativity between individual Ca(2+) channels in triggering exocytosis. Despite the wide use of these Ca(2+) sensitivity measurements, their interpretation often relies on heuristic arguments. Here we provide a detailed analysis of the Ca(2+) sensitivity measures probed by these experimental protocols, present simple expressions for special cases, and demonstrate the distinction between the Ca(2+) current cooperativity, defined by the relationship between exocytosis rate and the whole-terminal Ca(2+) current magnitude, and the underlying Ca(2+) channel cooperativity, defined as the average number of channels involved in the release of a single vesicle. We find simple algebraic expressions that show that the two are different but linearly related. Further, we use three-dimensional computational modeling of buffered Ca(2+) diffusion to analyze these distinct Ca(2+) cooperativity measures, and demonstrate the role of endogenous Ca(2+) buffers on such measures. We show that buffers can either increase or decrease the Ca(2+) current cooperativity of exocytosis, depending on their concentration and the single-channel Ca(2+) current.

  19. Weather Research and Forecasting Model Wind Sensitivity Study at Edwards Air Force Base, CA

    Science.gov (United States)

    Watson, Leela R.; Bauman, William H., III; Hoeth, Brian

    2009-01-01

    This abstract describes work that will be done by the Applied Meteorology Unit (AMU) in assessing the success of different model configurations in predicting "wind cycling" cases at Edwards Air Force Base, CA (EAFB), in which the wind speeds and directions oscillate among towers near the EAFB runway. The Weather Research and Forecasting (WRF) model allows users to choose among two dynamical cores - the Advanced Research WRF (ARW) and the Non-hydrostatic Mesoscale Model (NMM). There are also data assimilation analysis packages available for the initialization of the WRF model - the Local Analysis and Prediction System (LAPS) and the Advanced Regional Prediction System (ARPS) Data Analysis System (ADAS). Having a series of initialization options and WRF cores, as well as many options within each core, creates challenges for local forecasters, such as determining which configuration options are best to address specific forecast concerns. The goal of this project is to assess the different configurations available and determine which configuration will best predict surface wind speed and direction at EAFB.

  20. Trapping of oxygen vacancies on twin walls of CaTiO3: a computer simulation study

    International Nuclear Information System (INIS)

    Calleja, Mark; Dove, Martin T; Salje, Ekhard K H

    2003-01-01

    We have studied the atomic structure of [001] 90 deg. rotation twin walls in orthorhombic CaTiO 3 (symmetry Pbnm) at low temperature (10 K) and their effects on oxygen vacancies. The wall thickness was found to be 2.3 nm at T || T c and it was found that it is energetically favourable for such vacancies to reside in the wall, particularly when bridging titania ions in the (001) plane. The binding energy of an oxygen vacancy in the wall with respect to the bulk is calculated to be ≤ 1.2 eV

  1. Trapping of oxygen vacancies on twin walls of CaTiO sub 3 : a computer simulation study

    CERN Document Server

    Calleja, M; Salje, E K H

    2003-01-01

    We have studied the atomic structure of [001] 90 deg. rotation twin walls in orthorhombic CaTiO sub 3 (symmetry Pbnm) at low temperature (10 K) and their effects on oxygen vacancies. The wall thickness was found to be 2.3 nm at T || T sub c and it was found that it is energetically favourable for such vacancies to reside in the wall, particularly when bridging titania ions in the (001) plane. The binding energy of an oxygen vacancy in the wall with respect to the bulk is calculated to be <= 1.2 eV.

  2. Temperature dependent tunneling study of CaFe1.96Ni0.04As2 single crystals

    International Nuclear Information System (INIS)

    Dutta, Anirban; Gupta, Anjan K.; Thamizhavel, A.

    2014-01-01

    We report on temperature dependent scanning tunneling microscopy and spectroscopy studies on CaFe 1.96 Ni 0.04 As 2 single crystals in 5.4 – 19.7 K temperature range across the normal metal - superconductor transition temperature, T C = 14K. The in-situ cleaved crystals show reasonably flat surface with signatures of atomic resolution. The tunnel spectra show significant spatial inhomogeneity below T C , which reduces significantly as the temperature goes above the T C . We discuss these results in terms of an inhomogeneous electronic phase that may exist due to the vicinity of this composition to the quantum critical point

  3. Optimization of methylene blue using Ca(2+) and Zn(2+) bio-polymer hydrogel beads: A comparative study.

    Science.gov (United States)

    Kumar, M; Tamilarasan, R; Arthanareeswaran, G; Ismail, A F

    2015-11-01

    Recently noted that the methylene blue cause severe central nervous system toxicity. It is essential to optimize the methylene blue from aqueous environment. In this study, a comparison of an optimization of methylene blue was investigated by using modified Ca(2+) and Zn(2+) bio-polymer hydrogel beads. A batch mode study was conducted using various parameters like time, dye concentration, bio-polymer dose, pH and process temperature. The isotherms, kinetics, diffusion and thermodynamic studies were performed for feasibility of the optimization process. Freundlich and Langmuir isotherm equations were used for the prediction of isotherm parameters and correlated with dimensionless separation factor (RL). Pseudo-first order and pseudo-second order Lagegren's kinetic equations were used for the correlation of kinetic parameters. Intraparticle diffusion model was employed for diffusion of the optimization process. The Fourier Transform Infrared Spectroscopy (FTIR) shows different absorbent peaks of Ca(2+) and Zn(2+) beads and the morphology of the bio-polymer material analyzed with Scanning Electron Microscope (SEM). The TG & DTA studies show that good thermal stability with less humidity without production of any non-degraded products. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. "Nihil alieni a me alienum puto". L'alieno e il diverso nello spettacolo UFO Spotykacz di Paweł Passini

    Directory of Open Access Journals (Sweden)

    Barbara Minczewa

    2015-01-01

    Full Text Available On the basis of the Polish performance from 2009 UFO Spotykacz (UFO Encounter by the director Paweł Passini, this article presents and analyses how the figure of the alien – unusual for the theatre – became the figure of the Other. Three characters apply to be human being suited to meet an alien; this specific casting situation aiming to find the ideal person who could establish a "close encounter" opens the way to a series of questions about the condition of humanity in general and specifically about the condition of the contemporary society. The Freudian idea of Unheimlich, the theory of Julia Kristeva, and Giorgio Agamben's concept of anthropological machine help to answer to questions such as: is there anyone on Earth who truly represents humanity? and why does the Other – in this case represented by the alien – induce such strong emotions, from interest and desire to fear and hatred? The real meeting between the humans and the alien taking place at the end of the performance reveals only the phobias and frustrations of each character. The silent alien is here a metaphorical window that shows the lack of communication between human beings and the deepest fears of contemporary society.

  5. Beyond the Textbook: Studying Roswell in the Social Studies Classroom

    Science.gov (United States)

    Joseph, Brad

    2008-01-01

    Roswell has long been synonymous with aliens and UFOs, and people have been arguing over what happened that night in 1947 for many years. It is a topic left out of most textbooks and neglected in many social studies classrooms. However, Roswell has found a permanent place in American culture, and teaching about Roswell can be valuable to social…

  6. The study of optical property of sapphire irradiated with 73 MeV Ca ions

    Science.gov (United States)

    Yang, Yitao; Zhang, Chonghong; Song, Yin; Gou, Jie; Liu, Juan; Xian, Yongqiang

    2015-12-01

    Single crystals of sapphire were irradiated with 73 MeV Ca ions at room temperature to the fluences of 0.1, 0.5 and 1.0 × 1014 ions/cm2. Optical properties of these samples were characterized by ultraviolet-visible spectrometry (UV-VIS) and fluorescence spectrometer (PL). In UV-VIS spectra, it is observed the absorbance bands from oxygen single vacancy (F and F+ color centers) and vacancy pair (F2+ and F22+ color centers). The oxygen single vacancy initially increases rapidly and then does not increase in the fluence range from 0.1 to 0.5 × 1014 ions/cm2. When the fluence is higher than 0.5 × 1014 ions/cm2, oxygen single vacancy starts to increase again. Oxygen vacancy pair increases monotonically with fluence for all irradiated samples. The variation of oxygen single vacancy with fluence is probably associated with the recombination of oxygen vacancies with Al interstitials and complex defect formation (such as vacancy clusters). From PL spectra, two emission bands around 3.1 and 2.34 eV are observed. The PL intensity of the emission band around 3.1 eV decreases for all the irradiated samples. For the emission band around 2.34 eV, the PL intensity initially decreases, and then increases with fluence. Meanwhile, the peak position of the emission band around 2.34 eV gradually shifts to high energy direction with increase of fluence. The decrease of the intensity of the emission bands around 3.1 and 2.34 eV could be induced by stress from the damage layer in the irradiated samples. The shift of peak position for the emission band around 2.34 eV is induced by the appearance of emission band from Al interstitials.

  7. [Basic studies on CaO-P2O5-MgO-SiO2-CaF system glass ceramics. 2. Ultrastructural study on interface between culture cells and glass ceramics].

    Science.gov (United States)

    Hara, Y; Yoshimoto, Y; Abe, T; Maeda, K; Akamine, A; Aono, M

    1989-06-01

    The aim of this study was to determine biocompatibility of glass ceramics and adhesion of cultured cells to glass ceramics. Four established cultured cell lines, human fibrosarcoma cells (HT-1080), human gingival carcinoma cells (Ca9-22), human osteosarcoma cells (NY) and mouse osteoblasts (MC3T3-E1), were used. For phase-contrast and electron microscopic observation they were cultured on substrates of glass ceramics or polystyrene coverslips as a control. The results obtained were as follows. Glass ceramics caused neither cellular degeneration nor death, as revealed by phase-contrast microscopy. By transmission electron microscopy an amorphous structure similar to the basal lamina was observed at the interface between the substrates and Ca9-22, and between glass ceramics and NY. A similar structure sometimes existed between the substrates and MC3T3-E1. On the other hand HT-1080 showed no such structure. The findings suggest that the biocompatibility of glass ceramics was satisfactory. Furthermore, from the clinical point of view it seems to be possible to close the material-tissue interface with epithelial, fibrocytic and osteocytic cells.

  8. Ultra soft pseudo potential investigation of fundamental physical properties of CaXO3 (X=Sn and Hf) distorted perovskites: A reference study to the perfect perovskites

    International Nuclear Information System (INIS)

    Cherrad, Djellal; Maouche, D.; Boudissa, M.; Reffas, M.; Louail, L.; Maamache, M.; Haddadi, K.; Medkour, Y.

    2013-01-01

    The structural, electronic and optical properties of CaXO 3 distorted perovskites compounds have been investigated by employing the Vanderbilt Ultra Soft Pseudo Potential (US-PP) using the plane wave method (PW) within density functional theory (DFT) and the local density approximation LDA. The studies of the dependence with pressure of enthalpies have confirmed the excellent mechanical stability of these materials. We have found that these compounds have a direct band gaps (G–G). The (110) charge density contour show that these distorted compounds exhibit a zig zag electronic short chains in contrast of ideal perovskites presenting a perfectly aligned chains. Elastic–electronic correlation was established between Cij individual elastic constant and the bonding-anti bonding chemical bonds. After that, some above properties were studied under hydrostatic pressure effect. CaSnO 3 perovskite was very sensitive towards pressure than CaHfO 3 . The reflectivity maximum of these materials occurs in the ultra-violet energy ranges, which indicate that these perovskites can serve in some technological applications. Optical anisotropy shows that the compound CaSnO 3 is considered as more anisotropic than CaHfO 3 . Furthermore, anisotropy maximum was found to be according to [0 1 0] and [1 0 0] directions for CaHfO 3 and CaSnO 3 , respectively

  9. In situ scanning tunneling microscopy study of Ca-modified rutile TiO2(110 in bulk water

    Directory of Open Access Journals (Sweden)

    Giulia Serrano

    2015-02-01

    Full Text Available Despite the rising technological interest in the use of calcium-modified TiO2 surfaces in biomedical implants, the Ca/TiO2 interface has not been studied in an aqueous environment. This investigation is the first report on the use of in situ scanning tunneling microscopy (STM to study calcium-modified rutile TiO2(110 surfaces immersed in high purity water. The TiO2 surface was prepared under ultrahigh vacuum (UHV with repeated sputtering/annealing cycles. Low energy electron diffraction (LEED analysis shows a pattern typical for the surface segregation of calcium, which is present as an impurity on the TiO2 bulk. In situ STM images of the surface in bulk water exhibit one-dimensional rows of segregated calcium regularly aligned with the [001] crystal direction. The in situ-characterized morphology and structure of this Ca-modified TiO2 surface are discussed and compared with UHV-STM results from the literature. Prolonged immersion (two days in the liquid leads to degradation of the overlayer, resulting in a disordered surface. X-ray photoelectron spectroscopy, performed after immersion in water, confirms the presence of calcium.

  10. The prognostic significance of pre- and post-treatment CA-125 in grade 1 serous ovarian carcinoma: a gynecologic Oncology Group study.

    Science.gov (United States)

    Fader, Amanda Nickles; Java, James; Krivak, Thomas C; Bristow, Robert E; Tergas, Ana I; Bookman, Michael A; Armstrong, Deborah K; Tanner, Edward J; Gershenson, David M

    2014-03-01

    The study objective was to determine the prognostic significance of serum CA-125 levels in patients with grade 1 serous ovarian carcinoma (SOC) enrolled in a Phase III study. An ancillary analysis of a phase III study of women with advanced epithelial ovarian cancer treated with carboplatin/paclitaxel versus triplet or sequential doublet regimens. Grade 1 SOC was used as a surrogate for low-grade serous carcinoma. Among 3686 enrolled patients, 184 (5%) had grade 1 disease and CA-125 levels available. For those with grade 1 SOC, the median patient age was 56.5; 87.3% had Stage III disease. Median follow-up was 102 months and there was no difference in pre-chemotherapy CA-125 by treatment arm (P=0.91). Median pretreatment CA-125 for those with grade 1 SOC was lower (119.1) than for patients with grade 2-3 SOC (246.7; PCA-125 was not prognostic of outcome. However, patients with CA-125 levels that normalized after cycle 1, 2 or 3 were 60-64% less likely to experience disease progression as compared to those who never normalized or normalized after 4 cycles (P ≤ 0.024). Normalization of CA-125 levels before the second cycle was negatively associated with death, with a HR of 0.45 (P=0.025). Pretreatment CA-125 level was significantly lower in women with grade 1 SOC compared to those with high-grade SOC. While pretreatment CA-125 was not associated with survival, serial CA-125 measurements during chemotherapy treatment were prognostic, with normalization before the second chemotherapy cycle associated with a decreased risk of death. Copyright © 2013 Elsevier Inc. All rights reserved.

  11. ARPES studies of the inverse perovskite Ca3PbO : Experimental confirmation of a candidate 3D Dirac fermion system

    Science.gov (United States)

    Obata, Yukiko; Yukawa, Ryu; Horiba, Koji; Kumigashira, Hiroshi; Toda, Yoshitake; Matsuishi, Satoru; Hosono, Hideo

    2017-10-01

    We investigate the band structure of the inverse perovskite Ca3PbO , a candidate three-dimensional (3D) Dirac fermion material, through soft x-ray angle-resolved photoemission spectroscopy. Conelike band dispersions are observed for Ca3PbO , in close agreement with the predictions of electronic structure calculations. We further demonstrate that chemical substitution of Bi for Pb is effective in tuning the Fermi level of Ca3PbO while leaving its electronic structure intact. Our study confirms that the inverse perovskite family provides a promising platform for the exploration of 3D Dirac fermion systems.

  12. Crystal Growth and Neutron Scattering Study of Spin Correlations of the T‧-Structured Pr2‑x Ca x CuO4

    Science.gov (United States)

    Fujita, Masaki; Tsutsumi, Kenji; Miura, Tomohiro; Danilkin, Sergey

    2018-03-01

    We studied Ca-doping effect on spin correlations in T‧-structured cuprate oxide RE2CuO4 (RE: rear earth) with growing a sizable single crystal of Pr2‑x Ca x CuO4 (x=0.05 and 0.10) as well as synthesizing powder samples of Pr1.90Ca0.10CuO4 and Eu1.90Ca0.10CuO4. In the all as-prepared and annealed samples, no evidence of shielding signal associated with superconductivity was observed by magnetic susceptibility measurement. Elastic neutron scattering measurements on the as-grown Pr1.90Ca0.10CuO4 clarified the existence of long-ranged magnetic order with commensurate spin correlation. The ordering temperature was determined to be ∼290K, which is comparable to Néel temperature in the parent compound of Pr2CuO4. The existence of commensurate low-energy spin excitation was also confirmed by inelastic neutron scattering measurements for the annealed Pr1.95Ca0.05CuO4. These results strongly suggest a negligible Ca-doping effect on the physical properties in T‧-RE2CuO4, which is quite different from the drastic doping evolution of magnetism in T -RE2CuO4.

  13. An immunohistochemical study of the expression of the hypoxia markers Glut-1 and Ca-IX in canine sarcomas.

    Science.gov (United States)

    Abbondati, E; Del-Pozo, J; Hoather, T M; Constantino-Casas, F; Dobson, J M

    2013-11-01

    Tumor hypoxia has been associated with increased malignancy, likelihood of metastasis, and increased resistance to radiotherapy and chemotherapy in human medicine. Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor that is induced by tumor hypoxia and regulates the pathways involved in cellular response and adaptation to the hostile tumor microenvironment. HIF-1 induces transcription of different proteins, including Ca-IX and Glut-1, which are considered endogenous markers of chronic hypoxia in solid tumors in humans. In this study, sections from 40 canine sarcomas (20 histiocytic sarcomas and 20 low-grade soft-tissue sarcomas) were immunostained for these markers. Expression of Glut-1 was scored based on percentage of positive staining cells (0 = 50%) and intensity of cellular staining (1 = weak; 2 = strong); Ca-IX was scored based on percentage of positive cells (0 = 30%). Intratumoral microvessel density was measured using CD31 to assess intratumoral neoangiogenesis. Histiocytic sarcomas showed statistically significant higher Glut-1 immunoreactivity and angiogenesis than did low-grade soft-tissue sarcomas. Intratumoral microvessel density in histiocytic sarcomas was positively associated with Glut-1 immunoreactivity score. These findings suggest a potential role of hypoxia in the biology of these tumors and may provide a base for investigation of the potential prognostic use of these markers in naturally occurring canine tumors.

  14. Association of Plages with Sunspots: A Multi-Wavelength Study Using Kodaikanal Ca ii K and Greenwich Sunspot Area Data

    Energy Technology Data Exchange (ETDEWEB)

    Mandal, Sudip; Chatterjee, Subhamoy; Banerjee, Dipankar, E-mail: sudip@iiap.res.in [Indian Institute of Astrophysics, Koramangala, Bangalore 560034 (India)

    2017-02-01

    Plages are the magnetically active chromospheric structures prominently visible in the Ca ii K line (3933.67 Å). A plage may or may not be associated with a sunspot, which is a magnetic structure visible in the solar photosphere. In this study we explore this aspect of association of plages with sunspots using the newly digitized Kodaikanal Ca ii K plage data and the Greenwich sunspot area data. Instead of using the plage index or fractional plage area and its comparison with the sunspot number, we use, to our knowledge for the first time, the individual plage areas and compare them with the sunspot area time series. Our analysis shows that these two structures, formed in two different layers, are highly correlated with each other on a timescale comparable to the solar cycle. The area and the latitudinal distributions of plages are also similar to those of sunspots. Different area thresholdings on the “butterfly diagram” reveal that plages of area ≥4 arcmin{sup 2} are mostly associated with a sunspot in the photosphere. Apart from this, we found that the cyclic properties change when plages of different sizes are considered separately. These results may help us to better understand the generation and evolution of the magnetic structures in different layers of the solar atmosphere.

  15. CA19-9 Levels in Saliva and Urine of Patients with Ductal Adenocarcinoma of the Pancreas Correlates with Serum CA19-9 Levels - A Prospective Preliminary Study

    OpenAIRE

    Offir Ben-Ishay; Shirley Or Haim; Marielle Kaplan; Yoram Kluger

    2016-01-01

    Context Ductal adenocarcinoma of the pancreas is the fifth leading cause of cancer related deaths in the European Union. Tumor markers CA19-9 and carcinoembryonic antigen are important components in decision making and follow-up of patients diagnosed with this disease. These tumor markers were found to be elevated not only in the serum but also in other body fluids in patients with malignant lesions of the parotid gland and the urinary tract. Objectives The current preliminary study evaluates...

  16. Immunohistochemical study of tumor markers (CEA, TPA, CA19-9, POA and Ferritin) and pancreatic exocrine enzymes(Amylase and Elastase 1) in pancreatic tumors

    OpenAIRE

    脇谷, 勇夫

    1987-01-01

    The distribution of carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA), carbohydrate antigen 19-9 (CA19-9), pancreatic oncofetal antigen (POA), Ferritin, Amylase and Elastase 1 was studied immunohistochemically using an immunoperoxidase method in 26 conventional histopathologic sections of pancreatic tumor. CEA and CA19-9 were regarded as markers secreted into the glandular lumina from cancer cells, but TPA and POA were not. The expression of these markers was different from one...

  17. An Automatic Video Meteor Observation Using UFO Capture at the Showa Station

    Science.gov (United States)

    Fujiwara, Y.; Nakamura, T.; Ejiri, M.; Suzuki, H.

    2012-05-01

    The goal of our study is to clarify meteor activities in the southern hemi-sphere by continuous optical observations with video cameras with automatic meteor detection and recording at Syowa station, Antarctica.

  18. A Comparative Study of Apical Healing of Open Apices Using MTA and Ca(OH2 Apical Plugs in Cats

    Directory of Open Access Journals (Sweden)

    M. H. Zarrabi

    2005-06-01

    Full Text Available Statement of problem: Endodontic treatment of necrotic teeth with open apices is a challenge. After ruling out surgery as a treatment scheme and introduction of the multivisit apexification which in turn had its disadvantages, apical plug seems to be a suitable substitute treatment plan for such cases. Apical plug makes the treatment through formation of a barrier against the obturating material in a single visit.Purpose: The purpose of this study was to compare histologically the periapical healing using MTA and calcium hydroxide apical plugs after intervals of 4 and 12 weeks in cats.Materials and Methods: In this clinical trial study 64 canines of 16 healthy and mature cats were divided into 3 groups after a periapical lesion formation by over instrumentation in the apical area with files up to no.120. The first group included 24 teeth on which MTA apical plug was applied. The second group included 24 teeth on which Ca (OH 2 apical plug was applied. In both groups the canals were filled with gutta percha and sealer. The third group included 16 control teeth whose canals were left empty after instrumentation and debridement. The access cavities of all teeth were sealed with varnish and amalgam and the vital perfusion of cats was performed in 4 and 12 week intervals. Statistical analysis was established by χ2 and independence test.Results: After 4 weeks, periapical healing in the first group was 90%, in the second group 80% and in the third group, it was only 12.5 %. After 12 weeks, periapical healing occurred in 100% of the MTA group, while it was 57.1% in the second and 40%in the third group .Generally, in the study of histological parameters of healing, no statistical significant difference was observed between the 2 experimental groups,although the MTA group results were much better than the Ca (OH 2 group especially at 12 weeks.Conclusion: The use of MTA apical plug is more effective than Ca (OH 2 in treatment of necrotic teeth with open

  19. Evidence of the current collector effect: study of the SOFC cathode material Ca{sub 3}Co{sub 4}O{sub 9+{delta}}

    Energy Technology Data Exchange (ETDEWEB)

    Rolle, A.; Thoreton, V.; Capoen, E.; Mentre, O.; Daviero-Minaud, S. [Univ. Lille Nord de France, Lille (France); CNRS UMR 8181-Unite de Catalyse et de Chimie du Solide - UCCS, ENSC, USTL Villeneuve d' Ascq (France); Rozier, P. [Centre d' Elaboration de Materiaux et d' Etudes Structurales, UPR CNRS 8011, Toulouse (France); Boukamp, B. [Faculty of Science and Technology and MESA+, Institute for Nanotechnology, University of Twente, Enschede (Netherlands)

    2012-04-15

    In the study of the performance of solid oxide fuel cell (SOFC) electrodes, the possible influence of the applied current collector is often not mentioned or recognized. In this article, as part of an optimization study of the potentially attractive Ca{sub 3}Co{sub 4}O{sub 9+{delta}} cathode material (Ca349), special attention is paid to the choice of current collector. The influence of both gold and platinum paste or grid current collectors on pure and composite (Ca349 + 30 wt.% Gd-doped ceria) is studied, using electrochemical impedance spectroscopy (EIS). Although, platinum is catalytically active in the oxygen reduction reaction and then is often considered as current collector for SOFC cathodes, in combination with Ca349 cathodes, additional low frequency dispersion is observed, leading to a larger polarization resistance than found in the case of gold current collectors. A subsequent experiment revealed that Pt reacts with Ca349, forming undesirable phases: CaPt{sub 2}O{sub 4}, Ca{sub 4}PtO{sub 6}, Ca{sub 3}Co{sub 2}O{sub 6}, and Co{sub 3}O{sub 4}. The impedance spectra were analyzed with ZView 3.3a and with EqCwin v1.2. One series equivalent circuit was deduced using ZView, whereas, two possible equivalent circuits (series and nested), leading to the same quality of fits, were evidenced in EqCwin. The circuits are closely related to interactions of the current collector and layer thickness effects of the cathodes. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  20. Thermal and thermomechanical effects on the Al-Ca-Zn superplastic alloy studied on the positrons annihilation

    International Nuclear Information System (INIS)

    Romero, R.; Somoza, A.; Silvetti, S.P.

    1990-01-01

    Superplastic metallic materials are characterized by the presence of an unusual plastic behaviour, within a certain temperature range, with high ductility and low flow stress. This makes them suitable for their shaping with compressed air, for instance. On the other hand they behave similarly to any other metallic alloy at room temperature. One of the main problems found in superplastic alloys during deformation is the formation of cavities that may deteriorate the properties of a piece which was manufactured with this method. As an attempt to understand the origin of the cavitation, the effect of thermal and thermo-mechanical treatments was studied on superplastic alloy Al-5%wtCa-5%wtZn using a measurement technique based on positron annihilation. (Author). 3 refs., 5 figs

  1. Magnetocaloric as a sensitive tool to study magnetic phase in Ca4Mn3O10-δ

    Science.gov (United States)

    Mondal, Sampad; Modak, M.; Ray, M. K.; Mandal, Swapan K.; Sardar, M.; Banerjee, S.

    2018-02-01

    We report here magnetic properties of non-stoichiometric Ca4Mn3O10-δ . We have measured magnetization, electrical resistance, magnetoresistance, specific heat and thermo remanent magnetization (TRM) relaxation measurements. We find that at temperatures above 75 K the electrical transport can be explained in terms of activated hopping of magnetic polarons. These polarons are formed due to oxygen vacancy inducing Mn3+ sites. Below 50 K the polarons begins to strongly localize causing loss of moment and the electrical transport is governed by variable range hopping (VRH) conduction. The system shows glassy spin relaxation below 50 K, which presumably evolves into cluster spin glass at 12 K due to short range ordering of the canted moments. All these aspect could be well correlated with characteristics signature from magnetocaloric effect indicating magnetocaloric is a sensitive tool to study magnetic phase.

  2. Study on IL-2 and CA 15-3 level as combined biomarkers in monitoring chemotherapeutic response among invasive breast cancer patients

    Science.gov (United States)

    Hameed, Ahmed Muthanna Abdul; Hamid, Auni Fatin Abdul; Shahfiza Noor, Nurul; Appalanaido, Gokula Kumar; Bariyah Sahul Hamid, Shahrul

    2017-05-01

    In Malaysia, breast cancer is the most frequent type of disease among women. This study was designed to determine the clinical usefulness of carbohydrate antigen (CA 15-3) and interleukin 2 (IL-2) levels as combined biomarkers in monitoring breast cancer patient’s response to chemotherapy. Ethical approval was obtained to recruit patients with histologically confirmed invasive ductal carcinoma (IDC) attending Oncology Clinic at Advanced Medical and Dental Institute. Whole blood was collected from 10 IDC breast cancer patients’ pre and post primary chemotherapy. Plasma was separated from the whole blood to determine the CA 15-3 level and IL-2 level using enzyme-linked immunosorbent assay (ELISA) pre and post-treatment. In addition, the histological findings, tumour stage and other patients’ data were obtained from the medical record. Findings showed that IL-2 had borderline significant changes between pre- and post-chemotherapy (p = 0.074) whereas for CA 15-3, there was insignificant differences of CA 15-3 level between pre and post-chemotherapy (p > 0.05). It was noted that only CA 15-3 level had significant correlation with tumour size. This study demonstrates that IL-2 level requires further investigation in a larger sample size to correlate its potential use as combined biomarker with CA 15-3 in monitoring response to chemotherapy.

  3. SeO{sub 2} adsorption on CaO surface: DFT study on the adsorption of a single SeO{sub 2} molecule

    Energy Technology Data Exchange (ETDEWEB)

    Fan, Yaming; Zhuo, Yuqun; Lou, Yu; Zhu, Zhenwu [Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Department of Thermal Engineering, Tsinghua University, Beijing 100084 (China); Li, Liangliang [Key Laboratory of Advanced Materials, Department of Material Science and Engineering, Tsinghua University, Beijing 100084 (China)

    2017-08-15

    Highlights: • Adsorption mechanisms of SeO{sub 2} on CaO surface under O{sub 2} were firstly studied by DFT. • The adsorption energies, bond length and electron density maps were calculated. • The electronic structure changes upon adsorption were studied. - Abstract: Selenium is a hazardous element in coal. During coal combustion, most of the selenium will convert to SeO{sub 2} in the flue gas. Ca-based adsorbents, especially CaO, have been considered as a potential sorbent to adsorb SeO{sub 2} due to its low cost. In this paper, the adsorption mechanisms of single SeO{sub 2} on CaO surface were investigated by density functional theory (DFT) calculation. Both the physisorption and chemisorption structures were determined. It has been identified that the adsorption of SeO{sub 2} on CaO surface is primarily chemisorption, while physisorption takes effects at the initial stage of the process. Under O{sub 2} atmosphere, selenate is hard to form. Most of the adsorption products are selenite. Additionally, the electron density maps were obtained to reveal the surface active sites. The partial density of states (PDOS) was calculated for analyzing the electronic structural change of SeO{sub 2} and CaO surface during adsorption. The results provide fundamental information of the adsorption process, which could be meaningful for the development of new absorbents.

  4. Proposed cut-off value of CA19-9 for detecting pancreatic cancer in patients with diabetes: a case-control study.

    Science.gov (United States)

    Murakami, Mariko; Nagai, Yoshio; Tenjin, Ayumi; Tanaka, Yasushi

    2018-04-11

    Pancreatic cancer is a highly lethal malignancy. CA19-9 is a well-known marker for diagnosis of pancreatic cancer, but the serum CA19-9 level is reported to be elevated in patients with poorly controlled diabetes. This study evaluated the sensitivity, specificity, and cut-off value of serum CA19-9 for detection of pancreatic cancer in patients with diabetes. A case-control study of 236 patients was performed. The case group was selected from diabetic patients with pancreatic cancer, while one control was selected for each case from among diabetic patients without pancreatic cancer during the same period. The case group (n = 118) and the control group (n = 118) were matched for age, sex, and pancreatic cancer risk factors. Receiver operating characteristic (ROC) curves were plotted to determine the serum CA19-9 level that predicted pancreatic cancer. Then the sensitivity and specificity of CA19-9 were calculated for the threshold value. There were no significant differences of age, sex, BMI, smoking, alcohol intake, and HbA1c between the case and control groups. According to ROC analysis, a serum CA19-9 level of 75 U/mL had the maximum sensitivity and specificity for separating diabetic patients with or without pancreatic cancer. Using this cut-off value, the sensitivity and specificity of CA19-9 for pancreatic cancer was 69.5% and 98.2%, respectively, while the area under the ROC curve was 0.875 [95%CI: 0.826-0.924]. We propose that a serum CA19-9 level of 75 U/mL should be used as the cut-off value when screening patients with diabetes for pancreatic cancer.

  5. Significance of PIK3CA Mutations in Patients with Early Breast Cancer Treated with Adjuvant Chemotherapy: A Hellenic Cooperative Oncology Group (HeCOG Study.

    Directory of Open Access Journals (Sweden)

    George Papaxoinis

    Full Text Available The PI3K-AKT pathway is frequently activated in breast cancer. PIK3CA mutations are most frequently found in the helical (exon 9 and kinase (exon 20 domains of this protein. The aim of the present study was to examine the role of different types of PIK3CA mutations in combination with molecular biomarkers related to PI3K-AKT signaling in patients with early breast cancer.Tumor tissue samples from 1008 early breast cancer patients treated with adjuvant chemotherapy in two similar randomized trials of HeCOG were examined. Tumors were subtyped with immunohistochemistry (IHC and FISH for ER, PgR, Ki67, HER2 and androgen receptor (AR. PIK3CA mutations were analyzed by Sanger sequencing (exon 20 and qPCR (exon 9 (Sanger/qPCR mutations. In 610 cases, next generation sequencing (NGS PIK3CA mutation data were also available. PIK3CA mutations and PTEN protein expression (IHC were analyzed in luminal tumors (ER and/or PgR positive, molecular apocrine carcinomas (MAC; ER/PgR negative / AR positive and hormone receptor (ER/PgR/AR negative tumors.PIK3CA mutations were detected in 235/1008 tumors (23% with Sanger/qPCR and in 149/610 tumors (24% with NGS. Concordance between the two methods was good with a Kappa coefficient of 0.76 (95% CI 0.69-0.82. Lobular histology, low tumor grade and luminal A tumors were associated with helical domain mutations (PIK3CAhel, while luminal B with kinase domain mutations (PIK3CAkin. The overall incidence of PIK3CA mutations was higher in luminal as compared to MAC and hormone receptor negative tumors (p = 0.004. Disease-free and overall survival did not significantly differ with respect to PIK3CA mutation presence and type. However, a statistically significant interaction between PIK3CA mutation status and PTEN low protein expression with regard to prognosis was identified.The present study did not show any prognostic significance of specific PIK3CA mutations in a large group of predominantly lymph-node positive breast cancer

  6. Coastal processes study at Ocean Beach, San Francisco, CA: summary of data collection 2004-2006

    Science.gov (United States)

    Barnard, Patrick L.; Eshleman, Jodi; Erikson, Li H.; Hanes, Daniel M.

    2007-01-01

    Ocean Beach in San Francisco, California, contains a persistent erosional section in the shadow of the San Francisco ebb tidal delta and south of Sloat Boulevard that threatens valuable public infrastructure as well as the safe recreational use of the beach. Coastal managers have been discussing potential mediation measures for over a decade, with little scientific research available to aid in decision making. The United States Geological Survey (USGS) initiated the Ocean Beach Coastal Processes Study in April 2004 to provide the scientific knowledge necessary for coastal managers to make informed management decisions. This study integrates a wide range of field data collection and numerical modeling techniques to document nearshore sediment transport processes at the mouth of San Francisco Bay, with emphasis on how these processes relate to erosion at Ocean Beach. The Ocean Beach Coastal Processes Study is the first comprehensive study of coastal processes at the mouth of San Francisco Bay.

  7. Making UFOs make sense: Ufology, science, and the history of their mutual mistrust.

    Science.gov (United States)

    Eghigian, Greg

    2017-07-01

    Reports of unidentified flying objects and alien encounters have sparked amateur research (ufology), government investigations, and popular interest in the subject. Historically, however, scientists have generally greeted the topic with skepticism, most often dismissing ufology as pseudoscience and believers in unidentified flying objects and aliens as irrational or abnormal. Believers, in turn, have expressed doubts about the accuracy of academic science. This study examines the historical sources of the mutual mistrust between ufologists and scientists. It demonstrates that any science doubt surrounding unidentified flying objects and aliens was not primarily due to the ignorance of ufologists about science, but rather a product of the respective research practices of and relations between ufology, the sciences, and government investigative bodies.

  8. Identifying Unidentified Fermi-LAT Objects (UFOs) at High-Latitude

    Science.gov (United States)

    Cheung, Chi Teddy

    2009-09-01

    We propose a Chandra study of 8 high Galactic latitude gamma-ray sources in the Fermi-LAT bright source list. These sources are currently unidentified, i.e., they are not clearly associated with established classes of gamma-ray emitters like blazars and pulsars. The proposed observations will determine the basic properties (fluxes, positions, hardness ratio/spectra) of all X-ray sources down to a 0.3-10 keV flux limit of 1.5e-14 erg/cm2/s within the Fermi-LAT localization circles. This will enable further follow-up at other wavelengths, with the ultimate goal to reveal the nature of these enigmatic gamma-ray sources.

  9. Study of neutron-rich $^{51−53}$ Ca isotopes via $\\beta$-decay

    CERN Multimedia

    The high Q$_\\beta$ values in certain neutron-rich regions of the chart of nuclides opens up the possibility to study states in the daughter nuclei which lie at high excitation energy, above the neutron separation threshold. We propose to perform spectroscopy of the $\\beta$-delayed neutron emission of the $^{51-53}$K isotopes to study the population of single-particle or particle-hole states both below and above the neutron separation threshold. The VANDLE neutron detector will be used in combination with the IDS tape station setup and Ge detectors.

  10. Amniotic fluid CA-125 as a marker of intra-amniotic inflammation associated with preterm delivery: a preliminary single center study.

    Science.gov (United States)

    Seong, Won Joon

    2016-01-01

    The purpose of this study was to investigate whether amniotic fluid (AF) CA-125 in patients with preterm labor or preterm premature rupture of membranes can help predict intra-amniotic inflammation (IAI), microbial invasion of the amniotic cavity (MIAC) and imminent delivery. We recruited 36 women who admitted with impending preterm delivery and suspicious AF infection. AF matrix metalloproteinase-8 (MMP-8), white blood cell (WBC) count, glucose levels, and CA-125 levels were measured, and the MMP-8 bedside rapid test was also performed. AF culture and PCR were subsequently performed to confirm MIAC. We compared AF CA-125 levels according to the presence of IAI or MIAC and assessed its predictive value for delivery within 7 days of admission. AF CA-125 levels were significantly higher in the IAI group than in the non-IAI group (mean ± standard deviation: 5608 ± 864 vs 904 ± 84 IU/ml; p = 0.001). AF CA-125 levels showed a negative correlation with gestational age and a positive correlation with AF WBC counts and MMP-8 levels. AF CA-125 levels were higher in the MIAC group, though this difference was not statistically significant (p = 0.064). Delivery within 7 days of admission was significantly more common in patients with higher AF CA-125 levels (cut-off: 1650 IU/ml, sensitivity: 71.4 %, specificity: 86.4 %, p = 0.005). AF CA-125 levels are increased in patients with AF inflammation and can be a predictor of imminent preterm delivery.

  11. Pore-Scale Study of Transverse Mixing Induced CaCO 3 Precipitation and Permeability Reduction in a Model Subsurface Sedimentary System

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Changyong; Dehoff, Karl; Hess, Nancy; Oostrom, Mart; Wietsma, Thomas W.; Valocchi, Albert J.; Fouke, Bruce W.; Werth, Charles J.

    2010-10-15

    A microfluidic pore structure etched into a silicon wafer was used as a two-dimensional model subsurface sedimentary system (i.e., a micromodel) to study mineral precipitation and permeability reduction relevant to groundwater remediation and geological carbon sequestration. Solutions containing CaCl2 and Na2CO3 at four different saturation states (Ω = [Ca2+] [CO32-] / KspCaCO3) were introduced through two separate inlets and they mixed by diffusion transverse to the main flow direction along the center of the micromodel resulting in CaCO3 precipitation. Precipitation rates increased and the total amount of precipitates decreased with increasing saturation state, and only vaterite and calcite crystals were formed (no aragonite). The relative amount of vaterite increased from 80% at the lowest saturation (Ωv = 2.8 for vaterite) state to 95% at the highest saturation state (Ωv = 4.5). Fluorescent tracer tests conducted before and after CaCO3 precipitation indicate that pore spaces were completely occluded by CaCO3 precipitates along the transverse mixing zone, thus significantly reducing porosity and permeability, and potentially limiting transformation from vaterite to the more stable calcite. The results suggest that mineral precipitation along plume margins can decrease both reactant mixing during groundwater remediation, and injection and storage efficiency during CO2 sequestration.

  12. Comparative study of the radio-frequency magnetron sputter deposited CaP films fabricated onto acid-etched or pulsed electron beam-treated titanium

    International Nuclear Information System (INIS)

    Surmeneva, M.A.; Surmenev, R.A.; Tyurin, A.I.; Mukhametkaliyev, T.M.; Teresov, A.D.; Koval, N.N.; Pirozhkova, T.S.; Shuvarin, I.A.; Oehr, C.

    2014-01-01

    This study investigated the effect of the substrate morphology introduced by various substrate preparation techniques, namely acid etching (AE) and pulsed electron beam (PEB) treatments, on the CaP film morphology and mechanical properties. The morphology, nanohardness, and Young's modulus of the CaP coating deposited via radio-frequency (RF) magnetron sputtering were investigated by X-ray photoelectron spectroscopy (XPS), atomic force microscope (AFM), scanning electron microscopy and nanoindentation studies. The Ca/P ratios of the CaP coating deposited via RF magnetron sputtering onto titanium substrates treated using AE and PEB according to XPS were 1.73 ± 0.03 and 1.72 ± 0.04, respectively, which is close to the Ca/P ratio of 1.67 typical for stoichiometric hydroxyapatite (HA). The AFM experiments and nanoindentation studies revealed significant differences in the morphology and mechanical responses of the CaP films deposited onto acid-etched titanium substrates treated with PEB. Deposition of the CaP coating onto the acid-etched surface resulted in a rough surface with the presence of an island-like morphology. The CaP coating onto a smooth titanium substrate treated by PEB exhibited grains with irregular shapes and decreased size. The nanoindentation hardness and the Young's modulus of the HA coating deposited onto titanium treated by the PEB treatment were determined to be 7.0 ± 0.3 and 124 ± 3 GPa, respectively, which are significantly higher than those of the CaP coating on the acid-etched titanium substrates. Moreover, the elastic strain to failure (H/E), the plastic deformation resistance (H 3 /E 2 ), and the percent elastic recovery %R of the HA coating on titanium after surface irradiation with an electron energy density of 15 J·cm −2 were determined to increase by ∼ 23%, ∼ 70% and ∼ 53%, respectively, compared to the CaP coating on acid-etched titanium. - Highlights: • Island-like morphology of calcium phosphate coating on

  13. Simulating large-scale pedestrian movement using CA and event driven model: Methodology and case study

    Science.gov (United States)

    Li, Jun; Fu, Siyao; He, Haibo; Jia, Hongfei; Li, Yanzhong; Guo, Yi

    2015-11-01

    Large-scale regional evacuation is an important part of national security emergency response plan. Large commercial shopping area, as the typical service system, its emergency evacuation is one of the hot research topics. A systematic methodology based on Cellular Automata with the Dynamic Floor Field and event driven model has been proposed, and the methodology has been examined within context of a case study involving the evacuation within a commercial shopping mall. Pedestrians walking is based on Cellular Automata and event driven model. In this paper, the event driven model is adopted to simulate the pedestrian movement patterns, the simulation process is divided into normal situation and emergency evacuation. The model is composed of four layers: environment layer, customer layer, clerk layer and trajectory layer. For the simulation of movement route of pedestrians, the model takes into account purchase intention of customers and density of pedestrians. Based on evacuation model of Cellular Automata with Dynamic Floor Field and event driven model, we can reflect behavior characteristics of customers and clerks at the situations of normal and emergency evacuation. The distribution of individual evacuation time as a function of initial positions and the dynamics of the evacuation process is studied. Our results indicate that the evacuation model using the combination of Cellular Automata with Dynamic Floor Field and event driven scheduling can be used to simulate the evacuation of pedestrian flows in indoor areas with complicated surroundings and to investigate the layout of shopping mall.

  14. A comparative study of the 90Sr/Ca ratio in human diet and bone tissue

    International Nuclear Information System (INIS)

    Coulon, R.; Madelmont, C.

    1969-01-01

    A comparative study of both the evolution of strontium-90 content in the bones of individuals of different ages for the period 1962-1967 as related to calcium, and the corresponding diets allowed to establish the relationship between food contribution and the resulting bone burden. The study is mainly devoted to the group of adults for which a mathematical expression is proposed which allows for the exchangeable form of a skeletal calcium fraction turned over in less than a year from the dietary calcium, and the stabilized form constituting the larger part of bone tissue characterized by a slow turnover. Both the amount of the exchangeable fraction and the turnover rate of the stabilized fraction are determined for vertebrae and ribs. At birth, bone levels indicate that the calcium used for skeleton modelling during foetal life originates from both maternal diet and bone tissue and a value is given, to their relative significance. There appears a good relationship between bone levels in infants from 6 months to 1 year of age and their diets. The physiological parameters particular to this age are quantified. (authors [fr

  15. Food consumption patterns in Italy: the INN-CA Study 1994-1996.

    Science.gov (United States)

    Turrini, A; Saba, A; Perrone, D; Cialfa, E; D'Amicis, A

    2001-07-01

    The present study was aimed at surveying the Italian food consumption patterns in the 90s. It represented the second nationwide food intake survey that was carried out by the Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione (INRAN). Cross-sectional study. Free-living households. Sampled subjects: 1147 households randomly selected to be representative of the four main geographical areas (North-West, North-East, Centre, South). Analysed subjects: 1978 individuals out of 2734 initially collected in 15 Collaborative Centres strategically scattered through the national territory. A mixed 7-day based survey technique was applied in order to survey both individual and household consumption. At individual level, food intake was recorded by a self-compiled diary. At household level food data collection was by compilation of a food inventory by the dietician, a purchased/wasted foods diary and a recipes form both compiled by the person responsible for food related activities (decision of purchase, purchase, preparation of meals) in the household. All recorded data were monitored by the dieticians who visited the households participating in the study, at least three times. Household members were interviewed in order to collect socio-demographic, lifestyle and motivational information. Furthermore, field-workers performed the food coding and the input of data by an ad hoc developed software. The survey design allowed an internal quantitative check of food data. Several check steps were centrally performed The complex methodology caused the 46.8% response rate and afterwards a reduction of the analysed units (72% of the surveyed individuals). However, the analysed sample provided sufficiently reliable data for outlining the most relevant aspects of dietary patterns in Italy. In order to better interpret the results, controversial aspects are also illustrated and discussed in the text. The disparity analysis found that traditional diversities among Italian regions

  16. Somal and dendritic development of human CA3 pyramidal neurons from midgestation to middle childhood: a quantitative Golgi study.

    Science.gov (United States)

    Lu, Dahua; He, Lixin; Xiang, Wei; Ai, Wei-Min; Cao, Ye; Wang, Xiao-Sheng; Pan, Aihua; Luo, Xue-Gang; Li, Zhiyuan; Yan, Xiao-Xin

    2013-01-01

    The CA3 area serves a key relay on the tri-synaptic loop of the hippocampal formation which supports multiple forms of mnemonic processing, especially spatial learning and memory. To date, morphometric data about human CA3 pyramidal neurons are relatively rare, with little information available for their pre- and postnatal development. Herein, we report a set of developmental trajectory data, including somal growth, dendritic elongation and branching, and spine formation, of human CA3 pyramidal neurons from midgestation stage to middle childhood. Golgi-impregnated CA3 pyramidal neurons in fetuses at 19, 20, 26, 35, and 38 weeks of gestation (GW) and a child at 8 years of age (Y) were analyzed by Neurolucida morphometry. Somal size of the impregnated CA3 cells increased age-dependently among the cases. The length of the apical and basal dendrites of these neurons increased between 26 GW to 38 GW, and appeared to remain stable afterward until 8 Y. Dendritic branching points increased from 26 GW to 38 GW, with that on the apical dendrites slightly reduced at 8 Y. Spine density on the apical and basal dendrites increased progressively from 26 GW to 8 Y. These data suggest that somal growth and dendritic arborization of human CA3 pyramidal neurons occur largely during the second to third trimester. Spine development and likely synaptogenesis on CA3 pyramidal cells progress during the third prenatal trimester and may continue throughout childhood. Copyright © 2012 Wiley Periodicals, Inc.

  17. Liquid scintillation based quantitative measurement of dual radioisotopes (3H and 45Ca) in biological samples for bone remodeling studies.

    Science.gov (United States)

    Hui, Susanta K; Sharma, M; Bhattacharyya, M H

    2012-01-01

    Acute and prolonged bone complications associated with radiation and chemotherapy in cancer survivors underscore the importance of establishing a laboratory-based complementary dual-isotope tool to evaluate short- as well as long-term bone remodeling in an in vivo model. To address this need, a liquid scintillation dual-label method was investigated using different scintillation cocktails for quantitative measurement of (3)H-tetracycline ((3)H-TC) and (45)Ca as markers of bone turnover in mice. Individual samples were prepared over a wide range of known (45)Ca/(3)H activity ratios. Results showed that (45)Ca/(3)H activity ratios determined experimentally by the dual-label method were comparable to the known activity ratios (percentage difference ∼2%), but large variations were found in samples with (45)Ca/(3)H activity ratios in range of 2-10 (percentage difference ∼20-30%). Urine and fecal samples from mice administered with both (3)H-TC and (45)Ca were analyzed with the dual-label method. Positive correlations between (3)H and (45)Ca in urine (R=0.93) and feces (R=0.83) indicate that (3)H-TC and (45)Ca can be interchangeably used to monitor longitudinal in vivo skeletal remodeling. Copyright © 2011 Elsevier Ltd. All rights reserved.

  18. Ca2+-exchange in layered zirconium orthophosphate, α-ZrP: Chemical study and potential application for zinc corrosion inhibition

    Science.gov (United States)

    Bouali, Imane; Rocca, Emmanuel; Veys-Renaux, Delphine; Rhouta, Benaissa; Khalil, Aziza; Aït Aghzzaf, Ahmed

    2017-11-01

    The control of the corrosion phenomenon occurring at the metal interface requires the development of new non-toxic anticorrosion additives. For this purpose, zirconium orthophosphate compounds (Zr(HPO4)2,H2O noted α-ZrP) were synthesized by both hydrothermal and refluxing methods The Ca2+-cationic exchange in the layered structure is kinetically favoured by low crystallinity of α-ZrP synthesized by refluxing process, and leads to the formation of CaZr(PO4)2,4H2O, noted Ca2+-ZrP. The H+/Ca2+ exchange mechanism is mainly triggered by acid-base considerations, and especially the pKa of α-ZrP/Ca2+-ZrP acid-base couple (evaluated to 2.5). Both compounds are acidic compounds by internal exchangeable H+ for α-ZrP and surface protons for Ca2+-ZrP, and can be used as potential inhibitors of zinc corrosion. Electrochemical measurements show that Ca2+-ZrP compounds dispersed in the NaCl electrolyte buffer the pH value over a long time and therefore allow controlling the corrosion rate of zinc.

  19. Liquid scintillation based quantitative measurement of dual radioisotopes (3H and 45Ca) in biological samples for bone remodeling studies

    Science.gov (United States)

    Hui, Susanta K; Sharma, M; Bhattacharyya, M H

    2011-01-01

    Acute and prolonged bone complications associated with radiation and chemotherapy in cancer survivors underscore the importance of establishing a laboratory-based complementary dual-isotope tool to evaluate short- as well as long-term bone remodeling in an in vivo model. To address this need, a liquid scintillation dual-label method was investigated using different scintillation cocktails for quantitative measurement of 3H-tetracycline (3H-TC) and 45Ca as markers of bone turnover in mice. Individual samples were prepared over a wide range of known 45Ca/3H activity ratios. Results showed that 45Ca/3H activity ratios determined experimentally by the dual-label method were comparable to the known activity ratios (percentage difference ~2%), but large variations were found in samples with 45Ca/3H activity ratios in range of 2–10 (percentage difference ~ 20–30%). Urine and fecal samples from mice administered with both 3H-TC and 45Ca were analyzed with the dual-label method. Positive correlations between 3H and 45Ca in urine (R = 0.93) and feces (R = 0.83) indicate that 3H-TC and 45Ca can be interchangeably used to monitor longitudinal in vivo skeletal remodeling. PMID:21900015

  20. Study on the adsorption isosteres of the composite adsorbent CaCl2 and expanded graphite

    International Nuclear Information System (INIS)

    Li, S.L.; Wu, J.Y.; Xia, Z.Z.; Wang, R.Z.

    2011-01-01

    A test setup was built to study the adsorption performance of the composite adsorbent used in the adsorption system. The isovolume measurement method is adopted in the test setup to measure the adsorption isosteres of the composite adsorbent and ammonia working pair. The adsorption isosteres are the curves of the adsorption pressures variation with adsorption temperatures at constant adsorption quantity, which are convenient for the calculation of the adsorption heat and selection of the adsorption working pairs. The adsorption heats were calculated according to the adsorption isosteres, three clear crest values indicate that there were three types of reaction during the reaction processes of ammoniate calcium chloride and ammonia. The kinetic model of adsorption isosteres is obtained by the Temkin model, it is useful to estimate the adsorption performance of the working pairs and useful to guide the design of adsorption system.

  1. Hydrogen water deuterium exchange studies on palladium on activated charcoal hydrophobic catalyst (Preprint No. CA-20)

    International Nuclear Information System (INIS)

    Dubey, Krishna; Malaikar, N.L.; Pushpangathan, C.K.

    1989-04-01

    Deuterium exchange between hydrogen gas and water is one of the most promising processes for heavy water production. In production of heavy water, separation factor and energy cost are two main parameters which govern the economic effectiveness of a process. Out of the chemical exchange process, H 2 -H 2 O exchange has higher separation factor at a given temperature. Even though the separation factor is high, major disadvantage in the process is that a catalyst is required. Group VIII metals are most suitable catalysts for hydrogenation, dehydrogenation and hydrogenolysis because of their ability to chemisorb H 2 dissociatively. Even among VIII2 triad, Pt has the highest activity. A highly active Pt catalyst has a reported half life of 4 seconds. As Pd is cheaper than Pt, studies have been carried out using active Pd as catalyst for H 2 -H 2 O exchange. It is observed that: (1)at metal concentration of 0.3%, Pd shows the optimum catalytic activity, (2)a highly active Pd is found to have a half life of 5 minutes, and (3)addition of α-alumina enhances the catalytic activity. (author). 6 refs., 5 figs

  2. Study of neutron shell structure of even-even 40-56Ca isotopes by the dispersive optical model

    International Nuclear Information System (INIS)

    Bespalova, O.V.; Boboshin, I.N.; Varlamov, V.V.; Ermakova, T.A.; Ishkhanov, B.S.; Romanovskij, E.A.; Spasskaya, T.I.; Timokhina, T.P.

    2005-01-01

    The single-particle energies and occupation probabilities of the bound neutron states in 40,42,44,46,48 Ca isotopes were obtained by the joint evaluation of the stripping and pick-up reaction data. The results were analyzed by the dispersive optical model and a good agreement was achieved. The dispersive optical potential was extrapolated to unstable 50,52,54,56 Ca nuclei. The calculated single-particle energies of the bound neutron states in unstable Ca isotopes were compared with the nuclear shell-model calculations, which predicted new magic number N = 34 for nuclei with Z = 20 [ru

  3. Wave energy converter effects on wave propagation: A sensitivity study in Monterey Bay, CA

    Science.gov (United States)

    Chang, G.; Jones, C. A.; Roberts, J.; Magalen, J.; Ruehl, K.; Chartrand, C.

    2014-12-01

    The development of renewable offshore energy in the United States is growing rapidly and wave energy is one of the largest resources currently being evaluated. The deployment of wave energy converter (WEC) arrays required to harness this resource could feasibly number in the hundreds of individual devices. The WEC arrays have the potential to alter nearshore wave propagation and circulation patterns and ecosystem processes. As the industry progresses from pilot- to commercial-scale it is important to understand and quantify the effects of WECs on the natural nearshore processes that support a local, healthy ecosystem. To help accelerate the realization of commercial-scale wave power, predictive modeling tools have been developed and utilized to evaluate the likelihood of environmental impact. At present, direct measurements of the effects of different types of WEC arrays on nearshore wave propagation are not available; therefore wave model simulations provide the groundwork for investigations of the sensitivity of model results to prescribed WEC characteristics over a range of anticipated wave conditions. The present study incorporates a modified version of an industry standard wave modeling tool, SWAN (Simulating WAves Nearshore), to simulate wave propagation through a hypothetical WEC array deployment site on the California coast. The modified SWAN, referred to as SNL-SWAN, incorporates device-specific WEC power take-off characteristics to more accurately evaluate a WEC device's effects on wave propagation. The primary objectives were to investigate the effects of a range of WEC devices and device and array characteristics (e.g., device spacing, number of WECs in an array) on nearshore wave propagation using SNL-SWAN model simulations. Results showed that significant wave height was most sensitive to variations in WEC device type and size and the number of WEC devices in an array. Locations in the lee centerline of the arrays in each modeled scenario showed the

  4. Large Prospective Study of Ovarian Cancer Screening in High-risk Women: CA125 Cut-point Defined by Menopausal Status

    Science.gov (United States)

    Skates, Steven J.; Mai, Phuong; Horick, Nora K.; Piedmonte, Marion; Drescher, Charles W.; Isaacs, Claudine; Armstrong, Deborah K.; Buys, Saundra S.; Rodriguez, Gustavo C.; Horowitz, Ira R.; Berchuck, Andrew; Daly, Mary B.; Domchek, Susan; Cohn, David E.; Van Le, Linda; Schorge, John O.; Newland, William; Davidson, Susan A.; Barnes, Mack; Brewster, Wendy; Azodi, Masoud; Nerenstone, Stacy; Kauff, Noah D.; Fabian, Carol J.; Sluss, Patrick M.; Nayfield, Susan G.; Kasten, Carol H.; Finkelstein, Dianne M.; Greene, Mark H.; Lu, Karen

    2011-01-01

    Background Previous screening trials for early detection of ovarian cancer in postmenopausal women have used the standard CA125 cut-point of 35 U/mL, the 98th percentile in this population yielding a 2% false positive rate, while the same cut-point in trials of premenopausal women results in substantially higher false positive rates. We investigated demographic and clinical factors predicting CA125 distributions, including 98th percentiles, in a large population of high-risk women participating in two ovarian cancer screening studies with common eligibility criteria and screening protocols. Methods Baseline CA125 values and clinical and demographic data from 3,692 women participating in screening studies conducted by the NCI-sponsored Cancer Genetics Network and Gynecologic Oncology Group were combined for this pre-planned analysis. Due to the large effect of menopausal status on CA125 levels, statistical analyses were conducted separately in pre- and postmenopausal subjects to determine the impact of other baseline factors on predicted CA125 cut-points based on the 98th percentile. Results The primary clinical factor affecting CA125 cut-points was menopausal status, with premenopausal women having a significantly higher cut-point of 50 U/mL while in postmenopausal subjects the standard cut-point of 35 U/mL was recapitulated. In premenopausal women, current oral contraceptive (OC) users had a cut-point of 40 U/mL. Conclusions To achieve a 2% false positive rate in ovarian cancer screening trials and in high-risk women choosing to be screened, the cut-point for initial CA125 testing should be personalized primarily for menopausal status (~ 50 for premenopausal women, 40 for premenopausal on OC, 35 for postmenopausal women). PMID:21893500

  5. Evaluation of Preoperative Serum Levels of CA 125 and Expression of p53 in Ovarian Neoplasms: A Prospective Clinicopathological Study in a Tertiary Care Hospital.

    Science.gov (United States)

    Tiwari, Ranjan Kumar; Saha, Kaushik; Mukhopadhyay, Debasis; Datta, Chhanda; Chatterjee, Uttara; Ghosh, Tarun Kumar

    2016-04-01

    To assess the preoperative serum levels of CA 125 with its diagnostic role and to evaluate the p53 expression in patients of primary ovarian neoplasms. We also wished to judge their relationship with other parameters like clinical staging and histopathologic tumor type. The present study was conducted on 86 patients during the study period of 2.5 years. Preoperative CA 125 levels were evaluated by an automated immunoassay analyzer. p53 expression was judged immunohistochemically with pre-diluted monoclonal antibody. An objective scoring was done depending on distinct nuclear immunopositivity. Median value of preoperative CA 125 levels was 32 U/mL in benign surface epithelial-stromal tumors (BSEST), 53 U/mL in borderline surface epithelial-stromal tumors (BOT), 346 U/mL in malignant surface epithelial-stromal tumors (MSEST) and 560 U/mL in serous adenocarcinomas (SAC). Most of ovarian tumors were in the FIGO stage I (64 cases, 74.4%), but higher stages (II, III, IV) were observed mostly in MSESTs. SACs displayed the maximum p53 expression. Considering the cut-off value of more than 35 U/mL in CA 125 levels, the sensitivity to diagnose MSESTs was 94.7%. Preoperative CA 125 levels strongly and positively correlated with FIGO staging and p53 expression. Similarly p53 expression strongly and positively correlated with FIGO staging and histopathological categories. Higher values of preoperative CA 125 levels and higher expression p53 are associated with MSESTs and BOTs especially of serous type. They strongly correlate with each other and with tumor stage. But there is no serum CA 125 concentration that can clearly differentiate benign and malignant ovarian masses.

  6. An electron localization function study of the geometry of d(0) molecules of the period 4 metals Ca to Mn.

    Science.gov (United States)

    Gillespie, Ronald J; Noury, Stéphane; Pilmé, Julien; Silvi, Bernard

    2004-05-17

    We have studied the geometry of the formally d(0) MX(n)() (X = F, H, CH(3) and O; n = 2-6) molecules of the period 4 metals from Ca to Mn by studying the topology of the electron localization function (ELF) in order to try to understand why many of these molecules have non-VSEPR geometries. The quantitative analysis of the core basin population shows that it is always larger than its conventional value (18) because, in the LCAO-MO scheme, the 3d basis functions centered on the metal noticeably contribute to the electron density within the core region associated with the M shell. Therefore, the density available to form the bonds is less than Z(M) - 18, the value adopted in electron counts. Under the influence of the ligands, these electrons cause the core to lose its spherical symmetry by the formation of opposite-spin pair localization basins, which in turn influence the geometry of the ligands if the interaction of the ligands with the core is sufficiently strong. All of the ligands considered in this study, except F, interact with the core sufficiently strongly to give non-VSEPR geometries, which we have rationalized on the basis of the ELF topology.

  7. Phase diagram study for the PbO-ZnO-CaO-SiO{sub 2} -“Fe{sub 2}O{sub 3} ” system in air with CaO/SiO{sub 2} in 1.1 and PbO/(CaO+SiO{sub 2}) in 2.4 weight ratios

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Rodriguez, Josue; Romero-Serrano, Antonio; Hernandez-Ramirez, Aurelio; Cruz-Ramirez, Alejandro, E-mail: romeroipn@hotmail.com [Instituto Politecnico Nacional-ESIQIE, Zacatenco, Mexico City (Mexico); Almaguer-Guzman, Isaias; Benavides-Perez, Ricardo; Flores-Favela, Manuel [Servicios Administrativos Penoles S.A de C.V., Torreon, Coahuila (Mexico)

    2017-07-15

    An experimental study on the phase equilibrium and the liquidus isotherms for the PbO-ZnO-CaO-SiO{sub 2} -“Fe{sub 2}O{sub 3} ” system with CaO/SiO{sub 2} in 1.1 and PbO/(CaO+SiO{sub 2}) in 2.4 weight ratios, respectively, was carried out in the temperature range 1100-1300 deg C (1373-1573 K). High temperature phases were determined by the equilibrium-quenching method. Results are presented in the form of pseudo-ternary sections “Fe{sub 2}O{sub 3} ”-ZnO-(PbO+CaO+SiO{sub 2}). X-Ray diffraction (XRD) and SEM-EDS results showed that the phase equilibria in this system are dominated by the high melting temperature spinel and zincite phases. It was observed that if the system is at a temperature below 1300 deg C and the total (Fe{sub 2}O{sub 3} + ZnO) is greater than 20 wt%, spinel and/or zincite will be present in the slag system. As an application of the phase diagram, the liquid phase compositions below the liquidus surface were estimated, then their viscosities were calculated using FACTSage software. (author)

  8. A study on the piston ring wear in automotive engine Seat 1500 CA by means of radioactive tracer technique; Estudio del desgaste de segmentos en motor Seat 1500 CA mediante trazadores radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Val Cob, M. del; Chul, Y.; Fuentes Figuera de Vargas, J.

    1971-07-01

    The iron side wear in the chromium-plated top compression ring has been a matter of interest for the engine makers and it has been required by them to investigate the wear characteristics of the chromium-plated piston ring. Meanwhile, Bureau of Nuclear Energy in Spain (Junta de Energia Nuclear) and Seat Car Manufacturing Company (Sociedad Espanola de Automoviles de Turismo) agreed to study the wear characteristics of chromium-plated piston ring of type CA gasoline engine for Seat 1500 car by means of radioactive tracer technique. (Author) 9 refs.

  9. High speed cine film studies of plasma behaviour and plasma surface interactions in tokamaks

    International Nuclear Information System (INIS)

    Goodall, D.H.J.

    1982-01-01

    High speed cine photography is a useful diagnostic aid for studying plasma behaviour and plasma surface interactions. Several workers have filmed discharges in tokamaks including ASDEX, DITE, DIVA, ISX, JFT2, TFR and PLT. These films are discussed and examples given of the observed phenomena which include plasma limiter interactions, diverted discharges, disruptions, magnetic islands and moving glowing objects often known as 'UFOs'. Examples of plasma structures in ASDEX and DITE not previously published are also given. The paper also reports experiments in DITE to determine the origin of UFOs. (orig.)

  10. High speed cine film studies of plasma behaviour and plasma surface interactions in tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Goodall, D.H.J. (Euratom/UKAEA Fusion Association, Abingdon (UK). Culham Lab.)

    High speed cine photography is a useful diagnostic aid for studying plasma behaviour and plasma surface interactions. Several workers have filmed discharges in tokamaks including ASDEX, DITE, DIVA, ISX, JFT2, TFR and PLT. These films are discussed and examples given of the observed phenomena which include plasma limiter interactions, diverted discharges, disruptions, magnetic islands and moving glowing objects often known as 'UFOs'. Examples of plasma structures in ASDEX and DITE not previously published are also given. The paper also reports experiments in DITE to determine the origin of UFOs.

  11. S-Nitrosylation and uncompetitive/fast off-rate (UFO) drug therapy in neurodegenerative disorders of protein misfolding.

    Science.gov (United States)

    Nakamura, T; Lipton, S A

    2007-07-01

    Although activation of glutamate receptors is essential for normal brain function, excessive activity leads to a form of neurotoxicity known as excitotoxicity. Key mediators of excitotoxic damage include overactivation of N-methyl-D-aspartate (NMDA) receptors, resulting in excessive Ca(2+) influx with production of free radicals and other injurious pathways. Overproduction of free radical nitric oxide (NO) contributes to acute and chronic neurodegenerative disorders. NO can react with cysteine thiol groups to form S-nitrosothiols and thus change protein function. S-nitrosylation can result in neuroprotective or neurodestructive consequences depending on the protein involved. Many neurodegenerative diseases manifest conformational changes in proteins that result in misfolding and aggregation. Our recent studies have linked nitrosative stress to protein misfolding and neuronal cell death. Molecular chaperones - such as protein-disulfide isomerase, glucose-regulated protein 78, and heat-shock proteins - can provide neuroprotection by facilitating proper protein folding. Here, we review the effect of S-nitrosylation on protein function under excitotoxic conditions, and present evidence that NO contributes to degenerative conditions by S-nitrosylating-specific chaperones that would otherwise prevent accumulation of misfolded proteins and neuronal cell death. In contrast, we also review therapeutics that can abrogate excitotoxic damage by preventing excessive NMDA receptor activity, in part via S-nitrosylation of this receptor to curtail excessive activity.

  12. Urban Ecological Security Simulation and Prediction Using an Improved Cellular Automata (CA) Approach-A Case Study for the City of Wuhan in China.

    Science.gov (United States)

    Gao, Yuan; Zhang, Chuanrong; He, Qingsong; Liu, Yaolin

    2017-06-15

    Ecological security is an important research topic, especially urban ecological security. As highly populated eco-systems, cities always have more fragile ecological environments. However, most of the research on urban ecological security in literature has focused on evaluating current or past status of the ecological environment. Very little literature has carried out simulation or prediction of future ecological security. In addition, there is even less literature exploring the urban ecological environment at a fine scale. To fill-in the literature gap, in this study we simulated and predicted urban ecological security at a fine scale (district level) using an improved Cellular Automata (CA) approach. First we used the pressure-state-response (PSR) method based on grid-scale data to evaluate urban ecological security. Then, based on the evaluation results, we imported the geographically weighted regression (GWR) concept into the CA model to simulate and predict urban ecological security. We applied the improved CA approach in a case study-simulating and predicting urban ecological security for the city of Wuhan in Central China. By comparing the simulated ecological security values from 2010 using the improved CA model to the actual ecological security values of 2010, we got a relatively high value of the kappa coefficient, which indicates that this CA model can simulate or predict well future development of ecological security in Wuhan. Based on the prediction results for 2020, we made some policy recommendations for each district in Wuhan.

  13. Biosorption of uranium(VI) from aqueous solutions by Ca-pretreated Cystoseira indica alga: breakthrough curves studies and modeling.

    Science.gov (United States)

    Ghasemi, Morteza; Keshtkar, Ali Reza; Dabbagh, Reza; Jaber Safdari, S

    2011-05-15

    Uranium(VI) biosorption from aqueous solutions containing 60 mg l(-1) metal concentration by Ca-pretreated Cystoseira indica alga was studied in a packed bed column with 1.5 cm internal diameter. The effect of bed height and flow rate on biosorption process was investigated and the experimental breakthrough curves were obtained. Results showed that by increasing the bed height, the breakthrough and exhaustion times increased and the slope of breakthrough curves decreased. Also, it was observed that the controlled-rate step shifted from external to internal mass transfer limitations, as the flow rate increased. The maximum uptake capacity, 318.15 mg g(-1), and total metal removal, 59.32%, were obtained at flow rate of 2.3 ml min(-1) and bed height of 6 cm. The column was regenerated using 0.1M HCl solution and sorption-desorption studies were carried out for three cycles. The obtained results confirmed that reusability of this biosorbent is possible. The results obtained agreed well with the bed depth service time model. In addition, for estimations of the parameters necessary for the design of a large-scale packed bed column, the experimental data were also fitted to the Thomas, Yan and Belter models and were found to agree with the experimental data fairly well. Copyright © 2011 Elsevier B.V. All rights reserved.

  14. Biosorption of uranium(VI) from aqueous solutions by Ca-pretreated Cystoseira indica alga: Breakthrough curves studies and modeling

    Energy Technology Data Exchange (ETDEWEB)

    Ghasemi, Morteza [Faculty of Nuclear Engineering, Shahid Beheshti University, Tehran (Iran, Islamic Republic of); Keshtkar, Ali Reza, E-mail: akeshtkar@aeoi.org.ir [Nuclear Fuel Cycle School, Nuclear Science and Technology Research Institute, Tehran (Iran, Islamic Republic of); Dabbagh, Reza [Nuclear Science Research School, Nuclear Science and Technology Research Institute, Tehran (Iran, Islamic Republic of); Jaber Safdari, S. [Nuclear Fuel Cycle School, Nuclear Science and Technology Research Institute, Tehran (Iran, Islamic Republic of)

    2011-05-15

    Uranium(VI) biosorption from aqueous solutions containing 60 mg l{sup -1} metal concentration by Ca-pretreated Cystoseira indica alga was studied in a packed bed column with 1.5 cm internal diameter. The effect of bed height and flow rate on biosorption process was investigated and the experimental breakthrough curves were obtained. Results showed that by increasing the bed height, the breakthrough and exhaustion times increased and the slope of breakthrough curves decreased. Also, it was observed that the controlled-rate step shifted from external to internal mass transfer limitations, as the flow rate increased. The maximum uptake capacity, 318.15 mg g{sup -1}, and total metal removal, 59.32%, were obtained at flow rate of 2.3 ml min{sup -1} and bed height of 6 cm. The column was regenerated using 0.1 M HCl solution and sorption-desorption studies were carried out for three cycles. The obtained results confirmed that reusability of this biosorbent is possible. The results obtained agreed well with the bed depth service time model. In addition, for estimations of the parameters necessary for the design of a large-scale packed bed column, the experimental data were also fitted to the Thomas, Yan and Belter models and were found to agree with the experimental data fairly well.

  15. CO2 laser irradiation enhances CaF2 formation and inhibits lesion progression on demineralized dental enamel-in vitro study.

    Science.gov (United States)

    Zancopé, Bruna R; Rodrigues, Lívia P; Parisotto, Thais M; Steiner-Oliveira, Carolina; Rodrigues, Lidiany K A; Nobre-dos-Santos, Marinês

    2016-04-01

    This study evaluated if Carbon dioxide (CO2) (λ 10.6 μm) laser irradiation combined with acidulated phosphate fluoride gel application (APF gel) enhances "CaF2" uptake by demineralized enamel specimens (DES) and inhibits enamel lesion progression. Thus, two studies were conducted and DES were subjected to APF gel combined or not with CO2 laser irradiation (11.3 or 20.0 J/cm(2), 0.4 or 0.7 W) performed before, during, or after APF gel application. In study 1, 165 DES were allocated to 11 groups. Fluoride as "CaF2 like material" formed on enamel was determined in 100 DES (n = 10/group), and the surface morphologies of 50 specimens were evaluated by scanning electron microscopy (SEM) before and after "CaF2" extraction. In study 2, 165 DES (11 groups, n = 15), subjected to the same treatments as in study 1, were further subjected to a pH-cycling model to simulate a high cariogenic challenge. The progression of demineralization in DES was evaluated by cross-sectional microhardness and polarized light microscopy analyses. Laser at 11.3 J/cm(2) applied during APF gel application increased "CaF2" uptake on enamel surface. Laser irradiation and APF gel alone arrested the lesion progression compared with the control (p laser irradiation, combined with a single APF application enhanced "CaF2" uptake on enamel surface and a synergistic effect was found. However, regarding the inhibition of caries lesion progression, no synergistic effect could be demonstrated. In conclusion, the results have shown that irradiation with specific laser parameters significantly enhanced CaF2 uptake by demineralized enamel and inhibited lesion progression.

  16. Nd(III)/Cm(III) complexation with gluconate in NaCl and CaCl2 alkaline solutions: solubility and TRLFS studies

    International Nuclear Information System (INIS)

    Rojo, H.; Gaona, X.; Rabung, T.; Altmaier, M.; Garcia-Gutierrez, M.; Missana, T.

    2015-01-01

    Gluconic acid (GLU) is a poly-hydroxo-carboxylic acid expected in repositories for low and intermediate-level radioactive waste as a component of cementitious materials, added into the cement as water reducer and plasticiser. This work aims at assessing the solubility and aqueous speciation of An(III) and Ln(III) in the presence of GLU and dilute NaCl and CaCl 2 solutions, as background electrolytes. Under-saturation solubility studies with Nd(OH) 3 (am) were conducted in inert gas (Ar) gloveboxes at (22±2) C. degrees. Samples were prepared in dilute NaCl (0.1 M) and CaCl 2 (0.1 and 0.25 M) solutions as background electrolytes. Parallel experimental series were prepared with pH c = constant ≅ 12 and 10 -6 M ≤ [GLU] ≤ 10 -2 M, and with [GLU] = constant = 10 -3 M and 9 ≤ pH c ≤ 13. TRLFS measurements were performed with [Cm(III)] ∼ 10 -7 M per sample, and NaCl (0.1 M) and CaCl 2 (0.1 and 0.25 M) as background electrolytes. Three different concentration levels of Ca 2+ were considered in the NaCl systems: 0, 10 -3 M and 10 -2 M. The initial concentration of GLU in all samples (10 -6 M) was increased to 3.10 -3 M by step-wise additions of NaCl-NaGLU or CaCl 2 -CaGLU 2 solutions of appropriate ionic strength. The solubility of Nd(OH) 3 (am) remained unaffected by GLU in 0.1 M NaCl solutions. On the other hand, the solubility of Nd(OH) 3 (am) in 0.1 and 0.25 M CaCl 2 solutions was clearly increased by GLU under hyper-alkaline conditions. It was observed that the species forming are pH-dependent and unequivocally involve the participation of Ca 2+ , with the likely formation of a Nd-GLU complex with stoichiometry 1:2. No further increase of the Nd(III) concentration was observed at [GLU]tot ≥ 10 -3 M, resulting in an upper solubility limit at [Nd] ∼ 10 -6.5 M. This suggests the formation of a new Ca-Nd-GLU solubility limiting solid phase. Consistently with Nd(III) solubility data, TRLFS confirmed the key role of Ca 2+ in the complexation process, with the

  17. Initial stages of high-temperature CaF2/Si(001) epitaxial growth studied by surface X-ray diffraction.

    Science.gov (United States)

    Suturin, Sergey M; Sokolov, Nikolai S; Banshchikov, Aleksander G; Kyutt, Reginald N; Sakata, Osami; Shimura, Takayoshi; Harada, Jimpei; Tabuchi, Masao; Takeda, Yoshikazu

    2011-04-01

    Surface X-ray diffraction was applied to study structure of the fluorite-silicon interface forming upon epitaxial growth of CaF2 on Si(001) surface kept at 750 degrees C. Samples with CaF2 coverage of 1.5-4 (110)-monolayers were grown and in-situ characterized using synchrotron radiation. The 3 x 1-like surface reconstruction was observed in agreement with the previous studies by electron diffraction. Interestingly, a well pronounced splitting of the fractional x 1/3 reflections was revealed. This splitting was ascribed to the effect of antiphase domain boundaries in the row-like structure of the interface layer. The in-plane integrated intensities were used to reconstruct two-dimensional atomic structure of the high-temperature CaF2/Si(001) interface.

  18. CaCO3 dissolution by holothurians (sea cucumber): a case study from One Tree Reef, Great Barrier Reef

    Science.gov (United States)

    Schneider, K.; Silverman, J.; Kravitz, B.; Woolsey, E.; Eriksson, H.; Schneider-Mor, A.; Barbosa, S.; Rivlin, T.; Byrne, M.; Caldeira, K.

    2012-12-01

    Holothurians (sea cucumbers) are among the largest and most important deposit feeder in coral reefs. They play a role in nutrient and CaCO3 cycling within the reef structure. As a result of their digestive process they secrete alkalinity due to CaCO3 dissolution and organic matter degradation forming CO2 and ammonium. In a survey at station DK13 on One Three Reef we found that the population density of holothurians was > 1 individual m-2. The dominant sea cucumber species Holothuria leucospilota was collected from DK13. The increase in alkalinity due to CaCO3 dissolution in aquaria incubations was measured to be 47±7 μmol kg-1 in average per individual. Combining this dissolution rate with the sea cucumbers concentrations at DK13 suggest that they may account for a dissolution rate of 34.9±17.8 mmol m-2 day-1, which is equivalent to about half of night time community dissolution measured in DK13. This indicates that in reefs where the sea cucumber population is healthy and protected from fishing they can be locally important in the CaCO3 cycle. Preliminary result suggests that the CaCO3 dissolution rates are not affected by the chemistry of the sea water they are incubated in. Measurements of the empty digestive track volume of two sea cucumbers H. atra and Stichopus herrmanni were 36 ± 4 ml and 151 ± 14 ml, respectively. Based on these measurements it is estimated that these species process 19 ± 2kg and 80 ± 7kg CaCO3 sand yr-1 per individual, respectively. The annual dissolution rates of H. atra and S. herrmanni are 6.5±1.9g and 9.6±1.4g, respectively, suggest that 0.05±0.02% and 0.1±0.02% of the CaCO3 processed through their gut annually is dissolved. During the incubations the CaCO3 dissolution was 0.07±0.01%, 0.04±0.01% and 0.21±0.05% of the fecal casts for H. atra, H. leucospilota and S. herrmanni, respectively. Our result that the primary parameter determining the CaCO3 dissolution by sea cucumber is the amount of carbonate send in their gut

  19. Environmental Controls on Mg/Ca in Neogloboquadrina incompta: A Core-Top Study From the Subpolar North Atlantic

    Science.gov (United States)

    Morley, Audrey; Babila, Tali L.; Wright, James; Ninnemann, Ulysses; Kleiven, Kikki; Irvali, Nil; Rosenthal, Yair

    2017-12-01

    Magnesium/calcium paleothermometry is an established tool for reconstructing past surface and deep-sea temperatures. However, our understanding of nonthermal environmental controls on the uptake of Mg into the calcitic lattice of foraminiferal tests remains limited. Here we present a combined analysis of multiple trace element/calcium ratios and stable isotope (δ18O and δ13C) geochemistry on the subpolar planktonic foraminifera Neogloboquadrina incompta to assess the validity of Mg/Ca as a proxy for surface ocean temperature. We identify small size-specific offsets in Mg/Ca and δ18Oc values for N. incompta that are consistent with depth habitat migration patterns throughout the life cycle of this species. Additionally, an assessment of nonthermal controls on Mg/Ca values reveals that (1) the presence of volcanic ash, (2) the addition of high-Mg abiotic overgrowths, and (3) ambient seawater carbonate chemistry can have a significant impact on the Mg/Ca-to-temperature relationship. For carbonate-ion concentrations of values > 200 μmol kg-1, we find that temperature exerts the dominant control on Mg/Ca values, while at values < 200 μmol kg-1 the carbonate-ion concentration of seawater increases the uptake of Mg, thereby resulting in higher-than-expected Mg/Ca values at low temperatures. We propose two independent correction schemes to remove the effects of volcanic ash and carbonate-ion concentration on Mg/Ca values in N. incompta within the calibration data set. Applying the corrections improves the fidelity of past ocean temperature reconstructions.

  20. Urban Ecological Security Simulation and Prediction Using an Improved Cellular Automata (CA) Approach—A Case Study for the City of Wuhan in China

    Science.gov (United States)

    Gao, Yuan; Zhang, Chuanrong; He, Qingsong; Liu, Yaolin

    2017-01-01

    Ecological security is an important research topic, especially urban ecological security. As highly populated eco-systems, cities always have more fragile ecological environments. However, most of the research on urban ecological security in literature has focused on evaluating current or past status of the ecological environment. Very little literature has carried out simulation or prediction of future ecological security. In addition, there is even less literature exploring the urban ecological environment at a fine scale. To fill-in the literature gap, in this study we simulated and predicted urban ecological security at a fine scale (district level) using an improved Cellular Automata (CA) approach. First we used the pressure-state-response (PSR) method based on grid-scale data to evaluate urban ecological security. Then, based on the evaluation results, we imported the geographically weighted regression (GWR) concept into the CA model to simulate and predict urban ecological security. We applied the improved CA approach in a case study—simulating and predicting urban ecological security for the city of Wuhan in Central China. By comparing the simulated ecological security values from 2010 using the improved CA model to the actual ecological security values of 2010, we got a relatively high value of the kappa coefficient, which indicates that this CA model can simulate or predict well future development of ecological security in Wuhan. Based on the prediction results for 2020, we made some policy recommendations for each district in Wuhan. PMID:28617348

  1. Preparation, structural characterization, and in vitro cell studies of three-dimensional SiO2-CaO binary glass scaffolds built ofultra-small nanofibers.

    Science.gov (United States)

    Luo, Honglin; Li, Wei; Ao, Haiyong; Li, Gen; Tu, Junpin; Xiong, Guangyao; Zhu, Yong; Wan, Yizao

    2017-07-01

    Three-dimensional (3D) nanofibrous scaffolds hold great promises in tissue engineering and regenerative medicine. In this work, for the first time, 3D SiO 2 -CaO binary glass nanofibrous scaffolds have been fabricated via a combined method of template-assisted sol-gel and calcination by using bacterial cellulose as the template. SEM with EDS, TEM, and AFM confirm that the molar ratio of Ca to Si and fiber diameter of the resultant SiO 2 -CaO nanofibers can be controlled by immersion time in the solution of tetraethyl orthosilicate and ethanol. The optimal immersion time was 6h which produced the SiO 2 -CaO binary glass containing 60at.% Si and 40at.% Ca (named 60S40C). The fiber diameter of 60S40C scaffold is as small as 29nm. In addition, the scaffold has highly porous 3D nanostructure with dominant mesopores at 10.6nm and macropores at 20μm as well as a large BET surface area (240.9m 2 g -1 ), which endow the 60S40C scaffold excellent biocompatibility and high ALP activity as revealed by cell studies using osteoblast cells. These results suggest that the 60S40C scaffold has great potential in bone tissue regeneration. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Urban Ecological Security Simulation and Prediction Using an Improved Cellular Automata (CA Approach—A Case Study for the City of Wuhan in China

    Directory of Open Access Journals (Sweden)

    Yuan Gao

    2017-06-01

    Full Text Available Ecological security is an important research topic, especially urban ecological security. As highly populated eco-systems, cities always have more fragile ecological environments. However, most of the research on urban ecological security in literature has focused on evaluating current or past status of the ecological environment. Very little literature has carried out simulation or prediction of future ecological security. In addition, there is even less literature exploring the urban ecological environment at a fine scale. To fill-in the literature gap, in this study we simulated and predicted urban ecological security at a fine scale (district level using an improved Cellular Automata (CA approach. First we used the pressure-state-response (PSR method based on grid-scale data to evaluate urban ecological security. Then, based on the evaluation results, we imported the geographically weighted regression (GWR concept into the CA model to simulate and predict urban ecological security. We applied the improved CA approach in a case study—simulating and predicting urban ecological security for the city of Wuhan in Central China. By comparing the simulated ecological security values from 2010 using the improved CA model to the actual ecological security values of 2010, we got a relatively high value of the kappa coefficient, which indicates that this CA model can simulate or predict well future development of ecological security in Wuhan. Based on the prediction results for 2020, we made some policy recommendations for each district in Wuhan.

  3. Dynamic behaviour of Cd2+ adsorption in equilibrium batch studies by CaCO3(-)-rich Corbicula fluminea shell.

    Science.gov (United States)

    Ismail, Farhah Amalya; Aris, Ahmad Zaharin; Latif, Puziah Abdul

    2014-01-01

    This work presents the structural and adsorption properties of the CaCO3(-)-rich Corbicula fluminea shell as a natural and economic adsorbent to remove Cd ions from aqueous solutions under batch studies. Experiments were conducted with different contact times, various initial concentrations, initial solution pH and serial biosorbent dosage to examine the dynamic characterization of the adsorption and its influence on Cd uptake capacity. The characterization of the C. fluminea shell using SEM/EDX revealed that the adsorbent surface is mostly impregnated by small particles of potentially calcium salts. The dominant Cd adsorption mechanism is strongly pH and concentration dependent. A maximum Cd removal efficiency of 96.20% was obtained at pH 7 while the optimum adsorbent dosage was observed as 5 g/L. The Langmuir isotherm was discovered to be more suitable to represent the experimental equilibrium isotherm results with higher correlation coefficients (R(2) > 0.98) than Freundlich (R(2) < 0.97).The correlation coefficient values (p < 0.01) indicated the superiority of the Langmuir isotherm over the Freundlich isotherm.

  4. Control of ciliary motility by Ca2+: Integration of Ca2+-dependent functions and targets for Ca2+ action

    International Nuclear Information System (INIS)

    Evans, T.C.

    1988-01-01

    To identify functions that regulate Ca 2+ -induced ciliary reversal in Paramecium, mutants defective in terminating depolarization-induced backward swimming were selected. Six independent recessive mutations (k-shy) comprising two complementation groups, k-shyA and k-shyB, were identified. All mutants exhibited prolonged backward swimming in depolarizing solutions. Voltage clamp studies revealed that mutant Ca 2+ current amplitudes were reduced, but could be restored to wild type levels by EGTA injection. The recovery of the mutant Ca 2+ current from Ca 2+ -dependent inactivation, and the decay of the Ca 2+ -dependent K + and Ca 2+ -dependent Na + currents after depolarization were slow in k-shy compared to wild type. To identify protein targets of Ca 2+ action, ciliary proteins that interact with calmodulin (CaM) were characterized. With a 125 I-CaM blot assay, several CaM-binding proteins were identified including axonemal, soluble, and membrane-bound polypeptides. Competitive displacement studies with unlabeled Paramecium CaM, bovine CaM, and troponinC suggested that both protein types bind CaM with high affinity and specificity. To examine the presence of CaM-binding sites in intact axonemes, a filtration binding assay was developed

  5. A transmission electron microscopy study of radiation damages to β-dicalcium (Ca2SiO4) and M3-tricalcium (Ca3SiO5) orthosilicates

    Science.gov (United States)

    de Noirfontaine, Marie-Noëlle; Dunstetter, Frédéric; Courtial, Mireille; Signes-Frehel, Marcel; Wang, Guillaume; Gorse-Pomonti, Dominique

    2016-01-01

    In this paper, we present results of a first study of electron radiation damages to β-dicalcium silicate (Ca2SiO4:C2S) and M3-tricalcium silicate (Ca3SiO5:C3S) in a Transmission Electron Microscope. Electron irradiation is used here as a means to bring to light a difference of reactivity under the electron beam between these two complex ceramic oxides, keeping in mind that C3S reacts faster with water than C2S and that this property remains unexplained, owing to the complex structural characteristics of these ceramics which have not yet been fully elucidated. The following results were obtained by coupling TEM imaging and EDS analysis: i) Rapid decomposition of both silicate particles into CaO nano-crystals separated by (presumably SiO2-rich) amorphous areas at low flux for both silicates; ii) once reached a threshold electron flux, formation of an amorphous crater in both silicates, fully calcium-depleted in C3S but never in C2S; iii) significant post-mortem structural evolution of the craters that at least partially recrystallize in C2S, to be compared to the quasi frozen damaged area in C3S; iv) hole drilling at high flux but only in C3S once reached a threshold flux, ϕth ˜ 7.9 × 1021 e- cm-2 s-1, of the same order of magnitude than previously estimated in a number of ceramic materials, whereas C2S still amorphizes under the electron beam for a flux as high as 2.2 × 1022 e- cm-2 s-1. The radiation damages and their post-mortem evolution differ largely between C2S and C3S. We attempted to relate the obtained results, and especially the evolution of the Ca content in the damaged areas under the electron beam to the available structural characteristics of these two orthosilicates.

  6. Spectroscopic study of 44Ti by reactions 40Ca(α,γ)44Ti, 40Ca(7Li,p2nγ)44Ti and 42Ca(α,2nγ)44Ti

    International Nuclear Information System (INIS)

    Britz, Jean.

    1980-01-01

    The first reaction allowed to populate states of excitation energies between 9.2 and 9.8 MeV and to measure their γ-decays to low-lying states in 44 Ti. Moreover this reaction helps in measuring the mean lifetime of 12 states by using the Doppler shift attenuation method. The second reaction was used to find the levels predicted by the shell model and among them the highest spin allowed Jsup(π)=12 + . The third reaction helps in measuring the mean lifetime tau=3.0+-0.6 ns of the Jsup(π)=(12 + ) state at Esub(x)=8.040 MeV. In this measurement the delayed coincidence technique with a pulsed beam was used. A confrontation of the experimental and theoretical studies on the 44 Ti nucleus is presented in this work [fr

  7. Study of CaCl2 as an agent that modifies the surface of activated carbon used in sorption/treatment cycles for nitrate removal

    Directory of Open Access Journals (Sweden)

    O. Zanella

    2014-03-01

    Full Text Available The efficiency of the application of a chemically-modified activated carbon surface was investigated. The purpose of this study was to examine the effect of treatment with CaCl2 solution at a concentration of 2000 mg.L-1 on the sorption of nitrate ions from aqueous solutions in successive sorption/t reatment cycles. The sorbent was initially subjected to chemical treatment with CaCl2 and subsequently to the sorption process. Nine sorption cycles were performed. The concentrations of nitrate ions in the solution were measured by UV-Vis spectrophotometry before and after sorption. The results show that treatment with CaCl2 caused a significant increase in the percentage removal for each treatment step, reaching a removal rate of 80% of nitrate in the solution after nine cycles.

  8. Study on fast luminescence component induced by gamma-rays in Ce doped LiCaAlF6 scintillators

    International Nuclear Information System (INIS)

    Watanabe, Kenichi; Kondo, Yoshiyuki; Yamazaki, Atsushi; Uritani, Akira; Iguchi, Tetsuo; Kawaguchi, Noriaki; Fukuda, Kentaro; Ishizu, Sumito; Yanagida, Takayuki; Fujimoto, Yutaka; Yoshikawa, Akira

    2014-01-01

    We discuss the origin of the fast luminescence component induced by fast electrons generated in gamma-ray interactions in Ce doped LiCaAlF 6 scintillators. Although the slow luminescence component induced by Ce 3+ emissions depends on the Ce concentration in the LiCaAlF 6 scintillator, the fast component is independent. The fast component is suggested to be generated in the host matrix of the LiCaAlF 6 crystal. From quantitative considerations based on Frank–Tamm equation, which shows the light yield of the Cherenkov radiation, the Cherenkov radiation was determined as the origin of the fast component. We, additionally, found that the slow rise time of main Ce 3+ emissions in the Ce:LiCaAlF 6 scintillator plays an important role to perform the pulse shape discrimination. - Highlights: • The fast luminescence in Ce:LiCaAlF 6 scintillator is generated in the host matrix. • The origin of the fast luminescence is determined as the Cherenkov radiation. • The slow rise time also plays an important role to perform PSD

  9. Ca isotopic fractionation patterns in forest ecosystems

    Science.gov (United States)

    Kurtz, A. C.; Takagi, K.

    2012-12-01

    when the flux of new Ca into the system is small relative to plant uptake. When the Ca input flux is high relative to the uptake flux, the isotope ratio of the soil pool approaches that of the input ratio. We apply these observations to studies of δ44Ca distributions in forest ecosystems, both from published studies and from our own work at Luquillo, Puerto Rico and Hubbard Brook, New Hampshire. One result of this analysis is an apparent distinction between temperate and tropical systems. Tropical systems generally have soil exchange δ44Ca values heavier than input ratios. This suggests that the Ca return flux to the soil exchange pool is less than the Ca uptake flux. This would be expected if biological Ca is not 100% recycled back into soil. Temperate systems tend to have shallow soil exchange pool δ44Ca values lighter than inputs. This requires that the return of Ca from vegetation to the soil pool is larger than the Ca uptake flux by vegetation. This may be explained by the presence of deep-rooted trees such as beech that act as a "Ca pump", drawing Ca from deep soils and depositing it in shallow soils through litterfall.

  10. Comparative study on the adsorption of Co2+ on CaCO3 compounds used as adsorbents

    International Nuclear Information System (INIS)

    De Jesus V, S.

    2014-01-01

    The calcium carbonate (CaCO 3 ) was synthesized by methods of precipitation, calcination, sol-gel and trigonal/sol-gel. These materials were characterized by the techniques of X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, infrared spectroscopy and N 2 physisorption measurements in order to identify their textural, surface and structural properties. The results show that the material synthesized by sol-gel had the highest surface area of 39.5230 m 2 /g, and a total pore volume of 0.0484 m 3 /g and a pore diameter of 4.9050 nm. The synthesized materials were used to comparatively study their adsorption capacity of Co 2+ ions present in aqueous solutions, by experiments batch or batch type at an ambient temperature (25 grades C) and to 4 hours, balance time established previously under an adsorption kinetic study. They found as maximum adsorption capacities of Co 2+ in materials of 1.8582 mg/g for the calcium carbonate obtained by precipitation, of 0.8586 mg/g for the material obtained by calcining, of 3.1895 mg/g for the material obtained by sol-gel and finally of 2.5783 mg/g for the material obtained by the trigonal/sol-gel method, therefore it follows that the material having the highest adsorption capacity of Co 2+ ions was synthesized by the sol-gel method, because it showed better surface, textural and structural properties compared to other materials studied. (Author)

  11. A DFT-based comparative equilibrium study of thermal dehydration and hydrolysis of CaCl₂ hydrates and MgCl₂ hydrates for seasonal heat storage.

    Science.gov (United States)

    Pathak, Amar Deep; Nedea, Silvia; Zondag, Herbert; Rindt, Camilo; Smeulders, David

    2016-04-21

    Salt hydrates store solar energy in chemical form via a reversible dehydration-hydration reaction. However, as a side reaction to dehydration, hydrolysis (HCl formation) may occur in chloride based salt hydrates (specially in MgCl2 hydrates), affecting the durability of the storage system. The mixture of CaCl2 and MgCl2 hydrates has been shown experimentally to have exceptional cycle stability and improved kinetics. However, the optimal operating conditions for the mixture are unknown. To understand the appropriate balance between dehydration and hydrolysis kinetics in the mixtures, it is essential to gain in-depth insight into the mixture components. We present a GGA-DFT level study to investigate the various gaseous structures of CaCl2 hydrates and to understand the relative stability of their conformers. The hydration strength and relative stability of conformers are dominated by electrostatic interactions. A wide network of intramolecular homonuclear and heteronuclear hydrogen bonds is observed in CaCl2 hydrates. Equilibrium product concentrations are obtained during dehydration and hydrolysis reactions under various temperature and pressure conditions. The trend of the dehydration curve with temperature in CaCl2 hydrates is similar to the experiments. Comparing these results to those of MgCl2 hydrates, we find that CaCl2 hydrates are more resistant towards hydrolysis in the temperature range of 273-800 K. Specifically, the present study reveals that the onset temperatures of HCl formation, a crucial design parameter for MgCl2 hydrates, are lower than for CaCl2 hydrates except for the mono-hydrate.

  12. Distinct Roles for Dorsal CA3 and CA1 in Memory for Sequential Nonspatial Events

    Science.gov (United States)

    Farovik, Anja; Dupont, Laura M.; Eichenbaum, Howard

    2010-01-01

    Previous studies have suggested that dorsal hippocampal areas CA3 and CA1 are both involved in representing sequences of events that compose unique episodes. However, it is uncertain whether the contribution of CA3 is restricted to spatial information, and it is unclear whether CA1 encodes order per se or contributes by an active maintenance of…

  13. Study of positive parity levels in 41Ca and 41Sc: electromagnetic deexcitation of the 3/2 isospin states

    International Nuclear Information System (INIS)

    Fortier, Simone.

    1976-01-01

    The γ-decay of T=3/2 states in 41 Ca has been investigated by means of the 42 Ca( 3 He,αγ) 41 Ca reaction. Angular correlation measurements have been performed for γ-rays in coincidence with α particles emitted near 0 deg, and branching ratios extracted. The lowest T=3/2 level in 41 Sc (E=5,94MeV) has been excited as a resonance in the 40 Ca(p,γ) 41 Sc reaction, and radiative widths of γ-transitions were measured. The γ decay of the first T=3/2 level in 41 Sc is found to be quite similar to the one measured for the analog level in 41 Ca (E=5,92MeV), as it could be expected from corresponding ΔT=1 transitions in mirror nuclei. The M1 strengths are also compared with the ft values of β + transitions from the 41 Ti ground state. The orbital momentum part of the M1 operator is found to be important for three couples of γ-transition in 41 Ca and 41 Sc. These results suggest that the antianalog configuration could be in the ) 72.01-2.10MeV{ levels whereas the core-excited configurations (2 particles in the f7/2 shell coupled to J=1 and T=0 in the 74.09-4.25MeV{ levels and 74.73-4.77MeV{ levels. Experimental results are finally compared with the predictions of a shell model calculation performed for positive parity levels in A=41 nuclei, with 2 or 4 particles in the 1f7/2 shell and 1 or 3 holes in the 1d3/2 and 2s1/2 shells. )] [fr

  14. Charge and orbital ordering in Pr0.5Ca0.5MnO3 studied by O-17 NMR

    NARCIS (Netherlands)

    Yakubovskii, A; Trokiner, A; Verkhovskii, S; Gerashenko, A; Khomskii, D

    2003-01-01

    The charge and orbital ordering in Pr0.5Ca0.5MnO3 is studied for the first time by(17)O NMR. This local probe is sensitive to spin, charge, and orbital correlations. Two transitions exist in this system: the charge and orbital ordering at T-CO=225 K and the antiferromagnetic (AF) transition at

  15. An in-situ neutron diffraction study of the ageing of CaNi5Dx at 80ºC and 9 bar

    DEFF Research Database (Denmark)

    Pitt, M.P.; Brinks, H.W.; Jensen, Jens Oluf

    2004-01-01

    The intrinsic ageing of the CaNi5Dx system has been studied at 80 ◦C and 9 bar over a period of 13 days. The system displays a distinct two-phase mixture of the intermediate and phases, whose phase proportions approach 40 and 50 wt.%, respectively at the end of the ageing period. The change in pr...

  16. In vitro recapitulation of functional microvessels for the study of endothelial shear response, nitric oxide and [Ca2+]i.

    Directory of Open Access Journals (Sweden)

    Xiang Li

    Full Text Available Microfluidic technologies enable in vitro studies to closely simulate in vivo microvessel environment with complexity. Such method overcomes certain constrains of the statically cultured endothelial monolayers and enables the cells grow under physiological range of shear flow with geometry similar to microvessels in vivo. However, there are still existing knowledge gaps and lack of convincing evidence to demonstrate and quantify key biological features of the microfluidic microvessels. In this paper, using advanced micromanufacturing and microfluidic technologies, we presented an engineered microvessel model that mimicked the dimensions and network structures of in vivo microvessels with a long-term and continuous perfusion capability, as well as high-resolution and real-time imaging capability. Through direct comparisons with studies conducted in intact microvessels, our results demonstrated that the cultured microvessels formed under perfused conditions recapitulated certain key features of the microvessels in vivo. In particular, primary human umbilical vein endothelial cells were successfully cultured the entire inner surfaces of the microchannel network with well-developed junctions indicated by VE-cadherin staining. The morphological and proliferative responses of endothelial cells to shear stresses were quantified under different flow conditions which was simulated with three-dimensional shear dependent numerical flow model. Furthermore, we successfully measured agonist-induced changes in intracellular Ca2+ concentration and nitric oxide production at individual endothelial cell levels using fluorescence imaging. The results were comparable to those derived from individually perfused intact venules. With in vivo validation of its functionalities, our microfluidic model demonstrates a great potential for biological applications and bridges the gaps between in vitro and in vivo microvascular research.

  17. Sperm Na+, K+-ATPase and Ca2+-ATPase activity: A preliminary study of comparison of swim up and density gradient centrifugation methods for sperm preparation

    Science.gov (United States)

    Lestari, Silvia W.; Larasati, Manggiasih D.; Asmarinah, Mansur, Indra G.

    2018-02-01

    As one of the treatment for infertility, the success rate of Intrauterine Insemination (IUI) is still relatively low. Several sperm preparation methods, swim-up (SU) and the density-gradient centrifugation (DGC) are frequently used to select for better sperm quality which also contribute to IUI failure. Sperm selection methods mainly separate the motile from the immotile sperm, eliminating the seminal plasma. The sperm motility involves the structure and function of sperm membrane in maintaining the balance of ion transport system which is regulated by the Na+, K+-ATPase, and Ca2+-ATPase enzymes. This study aims to re-evaluate the efficiency of these methods in selecting for sperm before being used for IUI and based the evaluation on sperm Na+,K+-ATPase and Ca2+-ATPase activities. Fourteen infertile men from couples who underwent IUI were involved in this study. The SU and DGC methods were used for the sperm preparation. Semen analysis was performed based on the reference value of World Health Organization (WHO) 2010. After isolating the membrane fraction of sperms, the Na+, K+-ATPase activity was defined as the difference in the released inorganic phosphate (Pi) with and without the existence of 10 mM ouabain in the reaction, while the Ca2+-ATPase was determined as the difference in Pi contents with and without the existence of 55 µm CaCl2. The prepared sperm demonstrated a higher percentage of motile sperm compared to sperm from the whole semen. Additionally, the percentage of motile sperm of post-DGC showed higher result than the sperm from post-SU. The velocity of sperm showed similar pattern with the percentage of motile sperm, in which the velocity of prepared sperm was higher than the sperm from whole semen. Furthermore, the sperm velocity of post-DGC was higher compared to the sperm from post-SU. The Na+, K+-ATPase activity of prepared sperm was higher compared to whole semen, whereas Na+, K+-ATPase activity in the post DGC was higher than post SU. The Ca2

  18. The study of CaO and MgO heterogenic nano-catalyst coupling on transesterification reaction efficacy in the production of biodiesel from recycled cooking oil.

    Science.gov (United States)

    Tahvildari, Kambiz; Anaraki, Yasaman Naghavi; Fazaeli, Reza; Mirpanji, Sogol; Delrish, Elham

    2015-01-01

    Fossil fuels' pollution and their non-renewability have motivated the search for alternative fuels. Some common example of seed oils are sunflower oil, date seed oil, soy bean oil. For instance, soy methyl and soy-based biodiesel are the main biodiesel. Biodiesel is a clean diesel fuel that can be produced through transesterification reaction. Recycled cooking oil, on the other hand, is one of the inexpensive, easily available sources for producing biodiesel. This article is aimed at production of biodiesel via trans-esterification method, Nano CaO synthesis using sol-gel method, and Nano MgO synthesis using sol-gel self-combustion. Two catalysts' combination affecting the reaction's efficacy was also discussed. Optimum conditions for the reaction in the presence of Nano CaO are 1.5 % weight fracture, 1:7 alcohol to oil proportion and 6 h in which biodiesel and glycerin (the byproduct) are produced. Moreover, the optimum conditions for this reaction in the presence of Nano CaO and Nano MgO mixture are 3 % weight fracture (0.7 g of Nano CaO and 0.5 g of Nano MgO), 1:7 alcohols to oil proportion and 6 h. Nano MgO is not capable of catalyzing the transesterification by itself, because it has a much weaker basic affinity but when used with Nano CaO due to its surface structure, the basic properties increase and it becomes a proper base for the catalyst so that CaO contact surface increases and transesterification reaction yield significantly increases as well. This study investigates the repeatability of transesterification reaction in the presence of these Nano catalysts as well.

  19. HE4, CA125 and risk of ovarian malignancy algorithm (ROMA) as diagnostic tools for ovarian cancer in patients with a pelvic mass: An Italian multicenter study.

    Science.gov (United States)

    Romagnolo, Cesare; Leon, Antonette E; Fabricio, Aline S C; Taborelli, Martina; Polesel, Jerry; Del Pup, Lino; Steffan, Agostino; Cervo, Silvia; Ravaggi, Antonella; Zanotti, Laura; Bandiera, Elisabetta; Odicino, Franco E; Scattolo, Novella; Squarcina, Elisa; Papadakis, Christine; Maggino, Tiziano; Gion, Massimo

    2016-05-01

    This multicenter study aims to evaluate HE4, CA125 and risk of ovarian malignancy algorithm (ROMA) performance in the differential diagnosis of epithelial ovarian cancer (EOC). A total of 405 patients referred to gynecological oncologist with suspicious pelvic mass requiring a surgery for identification of EOC were consecutively enrolled; 387 patients satisfied inclusion criteria: 290 benign diseases; 15 borderline neoplasia and 82 tumors (73 EOC). Good diagnostic performance in discriminating benign from EOC patients was obtained for CA125, HE4 and ROMA when calculating optimal cut-off values: premenopause, specificity (SP) >86.6, sensitivity (SN) >82.6, area under the curves (AUC)≥0.894; postmenopause, SP>93.2, SN>82, AUC≥0.928. Fixing SP at 98%, performance indicators obtained for benign vs EOC patients were: premenopause, SN:65.2%, positive predictive value (+PV): 75%, positive likelihood ratio (+LR): 26.4 for CA125; SN:69.6%, +PV:76.2%, +LR:28.1 for HE4; SN:69.6%, +PV: 80%; +LR:35.1 for ROMA; postmenopause, SN:88%, +PV: 95.7%, +LR:38.7 for CA125; SN:78%, +PV:95.1%, +LR:34.3 for HE4; SN:88%, +PV:97.8%, +LR:77.4 for ROMA. When using routine cut-off thresholds, ROMA showed better well-balanced values of both SP and SN (premenopause, SN:87%, SP:86.1%; postmenopause, SN:90%; SP:94.3%). Overall, ROMA showed well balanced diagnostic performance to differentiate EOC from benign diseases. Meaningful differences of +PVs and +LRs between HE4 and CA125 suggest that the two markers may play at least in part different roles in EOC diagnosis, with HE4 seeming to be more efficient than CA125 in ruling in EOC patients in the disease group, also in early stages tumors, both in pre and postmenopause. Copyright © 2016. Published by Elsevier Inc.

  20. Gender differences in sexual and injection risk behavior among active young injection drug users in San Francisco (the UFO Study).

    Science.gov (United States)

    Evans, Jennifer L; Hahn, Judith A; Page-Shafer, Kimberly; Lum, Paula J; Stein, Ellen S; Davidson, Peter J; Moss, Andrew R

    2003-03-01

    Female injection drug users (IDUs) represent a large proportion of persons infected with HIV in the United States, and women who inject drugs have a high incidence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. Therefore, it is important to understand the role of gender in injection risk behavior and the transmission of blood-borne virus. In 2000-2002, 844 young (<30 years old) IDUs were surveyed in San Francisco. We compared self-reported risk behavior between 584 males and 260 female participants from cross-sectional baseline data. We used logistic regression to determine whether demographic, structural, and relationship variables explained increased needle borrowing, drug preparation equipment sharing, and being injected by another IDU among females compared to males. Females were significantly younger than males and were more likely to engage in needle borrowing, ancillary equipment sharing, and being injected by someone else. Females were more likely than males to report recent sexual intercourse and to have IDU sex partners. Females and males were not different with respect to education, race/ethnicity, or housing status. In logistic regression models for borrowing a used needle and sharing drug preparation equipment, increased risk in females was explained by having an injection partner who was also a sexual partner. Injecting risk was greater in the young female compared to male IDUs despite equivalent frequency of injecting. Overlapping sexual and injection partnerships were a key factor in explaining increased injection risk in females. Females were more likely to be injected by another IDU even after adjusting for years injecting, being in a relationship with another IDU, and other potential confounders. Interventions to reduce sexual and injection practices that put women at risk of contracting hepatitis and HIV are needed.

  1. Fishery livelihoods and (non)compliance with fishery regulations - A case study in Ca Mau Province, Mekong Delta, Vietnam

    NARCIS (Netherlands)

    Ha, T.T.P.; Dijk, van H.

    2013-01-01

    Fishery in Ca Mau, Viet Nam’s most southern province in the Mekong Delta, plays locally an important role for human nutrition and has great potentials for export earnings. The overexploitation of inshore fishing resources is a major problem in Viet Nam’s coastal areas along the Mekong Delta. As a

  2. (CaO)nIrO2 (n = 1, 2, 4) family: Chemical scissors effects of CaO on structural characteristics correlated to physical properties. Ab initio study

    Science.gov (United States)

    Matar, Samir F.; Etourneau, Jean

    2017-11-01

    Based on crystal chemistry analysis within Ca-Ir-O ternary, the generic (CaO)nIrO2 formula leading to CaIrO3 for n = 1, Ca2IrO4 for n = 2 and Ca4IrO6 for n = 4 actual chemical compounds show significant structural changes regarding the spatial arrangement of IrO6 octahedra whereby increasing amounts of CaO act as 'chemical scissor' decreasing the dimensionality of stacking octahedra from 3D (IrO2) to 0D (Ca4IrO6). This is accompanied by changes in the electronic structure investigated within density functional theory. Such changes are particularly exhibited by linear increase of Ir density of states at the Fermi level revealing increasing localization of d states with crystal field effects. Eventually only for Ca4IrO6 a magnetic instability occurs in non magnetic configuration. Spin polarized calculations lead to development of small magnitude but finite magnetization on Ir with M 0.50 μB totally polarized along minority spin channel ↓.

  3. Computational Study of the Transport Properties of Molten CaO-SiO2-P2O5-FeO System

    Science.gov (United States)

    Diao, Jiang; Zhang, Quan; Qiao, Yong; Jiang, Lu; Xie, Bing

    2018-01-01

    MD simulations have been accomplished to study the transport properties of molten CaO-SiO2-P2O5-FeO system. The self-diffusion coefficients of Ca, Si, P, Fe and O ions increase with increasing slag basicity and FeO content, while decrease with increasing P2O5 content. The diffusivities of these ions in the quaternary melts follow the sequence of Ca>Fe>O>P>Si. The calculated viscosities are in good agreement with the experimental ones. It is obvious that increasing the amount of network formers (e. g., Si and P ions) leads to larger viscosity and degree of slag polymerization, while adding network modifiers (e. g., Fe and Ca ions) causes viscosity and slag polymerization to decrease. Except for the calculation, the FT-IR analysis also confirmed the relationship between structural properties of the slag and composition. The viscosity of the slag increases linearly with increasing the parameter of Q(Si+P).

  4. Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

    International Nuclear Information System (INIS)

    Naguib, Adam; Arends, Mark J; Cooke, James C; Happerfield, Lisa; Kerr, Lucy; Gay, Laura J; Luben, Robert N; Ball, Richard Y; Mitrou, Panagiota N; McTaggart, Alison

    2011-01-01

    The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study investigates the prevalence of loss of PTEN expression and mutations in both PTEN and PIK3CA in colorectal cancers (CRC) and their associations with tumour clinicopathological features, lifestyle factors and dietary consumptions. 186 adenocarcinomas and 16 adenomas from the EPIC Norfolk study were tested for PTEN and PIK3CA mutations by DNA sequencing and PTEN expression changes by immunohistochemistry. Dietary and lifestyle data were collected prospectively using seven day food diaries and lifestyle questionnaires. Mutations in exons 7 and 8 of PTEN were observed in 2.2% of CRC and PTEN loss of expression was identified in 34.9% CRC. Negative PTEN expression was associated with lower blood low-density lipoprotein concentrations (p = 0.05). PIK3CA mutations were observed in 7% of cancers and were more frequent in CRCs in females (p = 0.04). Analysis of dietary intakes demonstrated no link between PTEN expression status and any specific dietary factor. PTEN expression negative, proximal CRC were of more advanced Dukes' stage (p = 0.02) and poor differentiation (p < 0.01). Testing of the prevalence of PIK3CA mutations and loss of PTEN expression demonstrated that these two events were independent (p = 0.55). These data demonstrated the frequent occurrence (34.9%) of PTEN loss of expression in colorectal cancers, for which gene mutations do not appear to be the main cause. Furthermore, dietary factors are not associated with loss of PTEN expression. PTEN expression negative CRC were not homogenous, as proximal cancers were associated with a more advanced Dukes' stage and poor differentiation, whereas distal cancers were associated with earlier Dukes' stage

  5. Prevalence and coexistence of KRAS, BRAF, PIK3CA, NRAS, TP53, and APC mutations in Indian colorectal cancer patients: Next-generation sequencing-based cohort study.

    Science.gov (United States)

    Jauhri, Mayank; Bhatnagar, Akanksha; Gupta, Satish; Bp, Manasa; Minhas, Sachin; Shokeen, Yogender; Aggarwal, Shyam

    2017-02-01

    Colorectal cancer incidences are on a rise in India. In this study, we have analyzed the mutation frequencies of six potential biomarkers, their coexistence, association with clinicopathological characteristics, and tumor location in Indian colorectal cancer patients. Next-generation sequencing was performed to identify mutations in the six potential biomarker genes using formalin-fixed paraffin-embedded tissue blocks of 112 colorectal cancer patients. The mutation frequency observed in KRAS, BRAF, PIK3CA, NRAS, TP53, and APC was 35.7%, 7.1%, 16.1%, 6.3%, 39.3%, and 29.5%, respectively. The significant associations of mutations were KRAS with age less than 60 years (p = 0.041), PIK3CA with males (p = 0.032), tumor stage I-II (p = 0.013), lack of metastasis in lymph nodes (p = 0.040), NRAS with rectum (p = 0.002), and APC with T2 stage of tumor growth (p = 0.013). No single patient harbored mutations in these six genes or any five genes simultaneously. Significance was noted in coexistence of KRAS with APC (p = 0.024) and mutual exclusion of KRAS with BRAF (p = 0.029). PIK3CA exon 9 was observed to be more frequently associated with KRAS mutations than PIK3CA exon 20 (p = 0.072). NRAS mutations were mutually exclusive with BRAF and PIK3CA mutations. As per our knowledge, this is the first next-generation sequencing-based biomarker study in Indian colorectal cancer patients. Frequent coexistence of gene mutations in pairs and triplets suggests that synergistic effect of overlapping mutations might further trigger the disease. In addition, infrequent coexistence of multiple gene mutations hints toward different signaling pathways for colorectal cancer tumorigenesis.

  6. Study of Raman Spectroscopy on Phase Relations of CaCO3 at High Temperature and High Pressure

    Science.gov (United States)

    Li, M.; Zheng, H.; Duan, T.

    2006-05-01

    Laser Raman Spectroscopy was used to study phase relations between calcite I, calcite II and aragonite at high pressure and high temperature. The experiment was performed in an externally heated Basselt type diamond anvil cell (DAC). Natural calcite (calcite I) was used as starting mineral. The sample and a small chip of quartz were loaded in a cavity (300 μm in diameter and 250 μm in depth) in a rhenium gasket. The Na2CO3 aqueous solution of 1mol/L was also loaded as a pressure medium to yield hydrostatic pressure. The whole assembly was pressurized first and then heated stepwise to 400°C. Pressure and temperature in the chamber were determined by the shift of Raman band at 464 cm-1 of quartz and by NiCr-NiSi thermocouple, respectively. The Raman spectra were measured by a Renishaw 1000 spetrometer with 50 mW of 514.5nm argon-ion laser as the excitation light source. The slit width was 50 μm and the corresponding resolution was ±1 cm-1. From the experiments, we observed the phase transitions between calcite I and calcite II, calcite I and aragonite, calcite II and aragonite, respectively. Our data showed a negative slope for the boundary between calcite I and calcite II, which was similar to Bridgman's result, although Hess et al. gave a positive slope. The boundary with a negative slope for calcite II and aragonite was also defined, which had never been done before. And all these data can yield a more complete phase diagram of CaCO3 than the studies of Hess et al. and Suito et al.Reference:Bridgeman P. W.(1939) Journal: American Journal of Science, Vol. 237, p. 7-18Bassett W. A. et al. (1993) Journal: Review of Scientific Instruments, Vol. 64, p. 2340-2345Suito K. et al. (2001) Journal: American Mineralogist, Vol. 86, p. 997- 1002Hess N. J. et al. (1991) In A. K. Singh, Ed., Recent Trends in High Pressure Research; Proc. X IIIth AIRAPT International Conference on High Pressure Science and Technology, p. 236-241. Oxford & IBH Publishing Co. Pvt, Ltd., New

  7. Studies on alkaline band formation in Chara corallina: ameliorating effect of Ca2+ on inhibition induced by osmotic shock.

    Science.gov (United States)

    Shimmen, Teruo; Yonemura, Satoko; Negoro, Mio; Lucas, William J

    2003-09-01

    Although the decrease in cell turgor by application of sorbitol to the external medium did not inhibit the alkaline band formation in Chara corallina, recovery of normal turgor severely inhibited it. Alkaline-loading analysis suggested that the inhibition of alkaline band formation was caused by inhibition of HCO(3)(-) influx but not that of OH(-) efflux. In the presence of 10 mM CaCl(2), the capacity of alkaline band formation was maintained during osmotic treatment. Cells could not form alkaline bands, when plasmolysis was induced by application of sorbitol at a higher concentration. Addition of 10 mM CaCl(2) could ameliorate the inhibition caused by plasmolyis.

  8. First-order phase transitions in CaFe2As2 single crystal: a local probe study

    International Nuclear Information System (INIS)

    Alzamora, M; Munevar, J; Baggio-Saitovitch, E; Bud'ko, S L; Ni Ni; Canfield, P C; Sanchez, D R

    2011-01-01

    57 Fe Moessbauer spectroscopy has been used to investigate the structural and magnetic phase transitions of CaFe 2 As 2 (T N = 173 K) single crystals. For this compound we found that V ZZ is positive and parallel to the c-axis of the tetragonal structure. For CaFe 2 As 2 a magnetic hyperfine field B hf was observed at the 57 Fe nucleus below T N ∼ 173 K. Analysis of the temperature dependence of B hf data using the Bean-Rodbell model shows that the Fe spins undergo a first-order magnetic transition at ∼ 173 K. A collinear antiferromagnetic structure is established below this temperature with the Fe spin lying in the (a, b) plane. Below T N the paramagnetic fraction of Fe decreases down to 150 K and for lower temperatures all the Fe spins are magnetically ordered.

  9. A validation study of the Hong Kong version of Montreal Cognitive Assessment (HK-MoCA) in Chinese older adults in Hong Kong.

    Science.gov (United States)

    Yeung, P Y; Wong, L L; Chan, C C; Leung, Jess L M; Yung, C Y

    2014-12-01

    To validate the Hong Kong version of Montreal Cognitive Assessment (HK-MoCA) in identification of mild cognitive impairment and dementia in Chinese older adults. Cross-sectional study. Cognition clinic and memory clinic of a public hospital in Hong Kong. A total of 272 participants (dementia, n=130; mild cognitive impairment, n=93; normal controls, n=49) aged 60 years or above were assessed using HK-MoCA. The HK-MoCA scores were validated against expert diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders (4th ed) criteria for dementia and Petersen's criteria for mild cognitive impairment. Statistical analysis was performed using receiver operating characteristic curve and regression analyses. Additionally, comparison was made with the Cantonese version of Mini-Mental State Examination and Global Deterioration Scale. The optimal cutoff score for the HK-MoCA to differentiate cognitive impaired persons (mild cognitive impairment and dementia) from normal controls was 21/22 after adjustment of education level, giving a sensitivity of 0.928, specificity of 0.735, and area under the curve of 0.920. Moreover, the cutoff to detect mild cognitive impairment was 21/22 with a sensitivity of 0.828, specificity of 0.735, and area under the curve of 0.847. Score of the Cantonese version of the Mini-Mental State Examination to detect mild cognitive impairment was 26/27 with a sensitivity of 0.785, specificity of 0.816, and area under the curve of 0.857. At the optimal cutoff of 18/19, HK-MoCA identified dementia from controls with a sensitivity of 0.923, specificity of 0.918, and area under the curve of 0.971. The HK-MoCA is a useful cognitive screening instrument for use in Chinese older adults in Hong Kong. A score of less than 22 should prompt further diagnostic assessment. It has comparable sensitivity with the Cantonese version of Mini-Mental State Examination for detection of mild cognitive impairment. It is brief and feasible to conduct in the

  10. A parametric study of the phase formation of in situ BiSrCaCuO thin films by laser ablation

    Science.gov (United States)

    Lin, Wen-Tai; Chen, Yung-Fu; Kao, Chih-Chang; Wu, Kuo-Chung

    1993-12-01

    The phase formation in BiSrCaCuO (BSCCO) films grown by in situ laser ablation has been studied as a function of excess concentrations of Ca and Cu in the target with oxidation gases such as O2 and N2O, gas pressures ranging from 0.02 to 10 Torr, and substrate temperatures ranging from 490 to 750 °C. A set of phase diagrams has been plotted illustrating O2 or N2O partial pressures vs substrate temperature, marking the stability fields and transitions among different phases of Bi2Sr2CuOx (2201), Bi2Sr2CaCu2Ox (2212), Bi2Sr2Ca2Cu3Ox (2223), and Bi2Sr2Ca3Cu4Ox (2234), amorphous products, and decomposition of the BSCCO films. In O2 and N2O, the first appearance of the 2212 phase is located at 510 °C/20 mTorr and 490 °C/100 mTorr, respectively. The BSCCO film decomposes at a high temperature that increases with increasing gas pressure. Higher gas pressures enhance the growth of the 2201 phase that may also be formed by cooling from partial film melting. Higher substrate temperature and gas pressure as well as the surplus of Ca and Cu in the target facilitate the growth of the 2223 and 2234 phases. The decomposition curve of the Ca and Cu enhanced BSCCO films is shown to be found at lower temperatures in comparison to the stability lines of the 2212 and 2223 phases; furthermore, its slope deviation occurs at 650-690 °C which is lower by as much as about 130 °C compared to that of stoichiometric superconductors. Nearly pure 2212, 2223, or 2234 films or a mixture of them can be grown within a temperature range of 575-690 °C at a pressure as high as 10 Torr, irrespective of the kind of oxidation gas.

  11. Study of the role of complete fusion in the reaction of 48Ca and 56Fe with cerium and terbium

    International Nuclear Information System (INIS)

    Morrissey, D.J.

    1978-05-01

    48 Ca and 56 Fe beams from the Super HILAC accelerator were used to irradiate thick metal foils of cerium and terbium. Product gamma ray activities were detected offline and individual products were identified by half-life, gamma ray energy and gamma ray abundances. The production cross sections were iteratively fit to charge and mass dispersions to allow correction for parent decay and calculation of mass yields. From the mass yield curves contributions from quasielastic transfer, deep inelastic transfer and complete fusion reaction mechanisms were interred. Complete fusion was made up on contributions from both evaporation residue and fusion-fission products for the 48 Ca induced reactions. However, only fusion-fission products were detected in the 56 Fe induced reactions. Critical angular momenta for fusion were found to be 82 +- 8 h for 48 Ca + 159 Tb and 34 +- 5 h for 56 Fe + 140 Ce, which can be compared with 53 +- 8 h for 12 C + 197 Au (Natowitz, 1970) and 86 +- 5 h for 40 Ar + 165 Ho (Hanappe, 1973). All of these reactions lead to essentially the same compound nucleus and seem to show the dramatic decline in complete fusion for heavy ions larger than 40 Ar. The prediction of this decline was found to be beyond the model calculations of Bass and the critical distance approach of Glas and Mosel

  12. Structural and optical study of CaF{sub 2} nanoparticles produced by a microwave-assisted hydrothermal method

    Energy Technology Data Exchange (ETDEWEB)

    Bezerra, Claudiane dos S., E-mail: cdsantos20@gmail.com; Valerio, Mário E.G.

    2016-11-15

    CaF{sub 2} nanoparticles were synthesized by the microwave-assisted hydrothermal method. With the addition of the ethylenediamine (EDA) as chelating agent, the size of the particles was reduced. The CaF{sub 2} exhibit single phase identified for X-ray diffraction (XRD) and confirmed by Rietveld refinement. Scanning electron microscopy (SEM) images showed nanoparticles with non-uniform morphology and statistical analysis of collections of particles reviewed that the EDA decreases both the average particle size and average aspect ratio of the particles. The chemical composition of the surface of the particles was investigated by X-ray Photoelectron Spectroscopy (XPS) and the results indicated the presence of reasonable amounts of hydroxyl groups and oxygen ions in the samples produced with EDA. Radioluminescence (RL) measurements showed that both types of nanoparticles presented intrinsic scintillation emission formed by two main bands and that the CaF{sub 2} samples produced without EDA presented higher emission intensity. The broad RL band centered at approximately 293 nm is related to self-trapped exciton (STE) emission of calcium fluoride, while the band at 428 nm can be due to the presence of F centers. The STE excitation and optical band gap were measured through photoluminescent excitation spectra in the VUV range.

  13. First-principles study on hydrogen storage in Al-, Ca-, Mn-doped MgNi clusters

    Science.gov (United States)

    Ma, Wenqiang; Jing, Cuiyu

    2017-10-01

    Using a density functional approach calculation, the structural and electronic properties of Mg8Ni5, Mg8Ni4Al, Mg8Ni4Ca and Mg8Ni4Mn clusters are investigated. The Al-, Ca-, Mn-doping in MgNi clusters lengthen d(Mg-Ni), also increase the Mulliken charge, and improve magnetic moment on most shell atoms, so that the doping is helpful for hydrogen storage. The reaction heats of hydrogenation, the enthalpies of formation, the desorption energies show that the Mg8Ni4Mn, Mg8Ni5, Mg8Ni4Al clusters have a good property of hydrogen storage materials with relatively higher reaction heat of hydrogenation, and that their hydrides have a smaller desorption energy. So the Mg8Ni4M (M = Ni, Al, Ca, Mn) clusters are some preferred candidates of H storage. These results indicate the advantage of small size and suitable metal-doped MgNi clusters on hydrogenation and dehydrogenation.

  14. Vitreous Anorthite (CaAl2Si2O8) at High Pressure: A First-Principles Molecular Dynamics Study

    Science.gov (United States)

    Ghosh, D. B.; Karki, B. B.

    2017-12-01

    Due to the high abundance of silicates and aluminosilicates inside the earth, their corresponding melts are likely to be one of the key transport agents in the chemical and thermal evolution of our planet and therefore, have long been the subject of investigations. Experimentally, in-situ melt properties of these materials, particularly at high pressure-temperature conditions are extremely difficult to constrain and the corresponding glass phases are considered as analogs. This, however, prohibits one-to-one comparison between the properties of silicate melt and its corresponding glass. With the aim to enable such comparison, we investigate the equation of state and structural properties of CaAl2Si2O8 glass at 300 K as a function of pressure up to 160 GPa from first principles molecular dynamics simulation results. Our results show that at ambient pressure: (i) Si's remain mostly (> 95%) under tetrahedral oxygen surroundings, (ii) unlike anorthite crystal, presence of high coordination (> 4) Al's with 30% abundance, (iii) and significant presence of both non bridging (8%) and triply (17%) coordinated oxygen. In the 0-10 GPa interval, mainly topological changes occur in the Si-O (also Al-O to some extent) surroundings in the cold compressed case in comparison to smooth increase in the average bond distance and coordination in the hot compressed case. Further compression results in gradual increases in: mean coordination, proportion of O-triclusters and increasing appearance of tetrahedral oxgyens, with Si-O (Al-O) reaching 6 (6.5) and O-T > 3 (T=Si and Al) at the highest compression. Due to the absence of kinetic barrier, the hot compressed glasses consistently produce greater densities and higher coordination numbers than the cold compression cases. Decompressed glasses show irreversible compaction along with retention of high coordination species when decompressed from > 10 GPa and degree of irreversibility depends on the peak pressure of decompression. These

  15. Correlation of Preoperative Ki67 and Serum CA15.3 Levels with Outcome in Early Breast Cancers a Multi Institutional Study.

    Science.gov (United States)

    Rasmy, A; Abozeed, W; Elsamany, S; Baiomy, M El; Nashwa, A; Amrallah, A; Hasaan, E; Alzahrani, A; Faris, M; Alsaleh, K; AlFaraj, A

    2016-01-01

    To investigate the association between preoperative pathological Ki67 labeling index and serum tumor marker cancer antigen 153 (CA 153) with clinicpathological parameters and treatment outcomes in early breast cancer. A retrospective study at 4 cancer centers in Saudi Arabia and Egypt was performed. Data were collected for female patients diagnosed with unilateral early breast cancer between March 2010 and October 2013. Cases treated with neoadjuvant chemotherapy (NACT) followed by surgery and radiotherapy were included. NACT included 68 cycles of anthracycline and taxane based regimens. Trastuzumab and hormonal treatments were added according to HER2 and hormone receptor status. Baseline serum CA15.3 and pathological Ki67 levels were evaluated and correlated with disease free survival (DFS) and overall survival (OS). A total of 280 pts was included. The median age was 49 years (3866 y) and median overall survival was 35 (2038) months (mo). Estrogen receptors (ER), progesterone receptors (PR) and HER 2 receptors were positive in 233 (83.2%), 198 (70%) and 65 cases (23.2%), respectively. High preoperative Ki67 and CA15.3 were noted in 177 (63.2%) and 131 (46.8%). A total of 45 (16%) patients had distal or local recurrence and 24 (8.6%) died of their disease. Most of the relapsed cases had high preoperative Ki67 (n=41, 91%) and CA15.3 (n=28, 62%) values. All of the patients who died had a high Ki67 but CA15.3 was high in 9 (37%) only. Mean DFS/OS in patients with high preoperative Ki67 was 32 months /32 months as compared to 37 months/35 months in those with normal Ki67 (pKi67 can be a predictive and prognostic marker. Higher levels are associated with poor DFS and OS in patients with early BC.

  16. Preparation, structural study from neutron diffraction data and magnetism of the disordered perovskite Ca(Cr0.5Mo0.5)O3

    International Nuclear Information System (INIS)

    Martinez-Lope, M.J.; Alonso, J.A.; Casais, M.T.; Garcia-Hernandez, M.; Pomjakushin, V.

    2006-01-01

    We report on the preparation and characterization of the Ca(Cr 0.5 Mo 0.5 )O 3 perovskite, obtained in the search of the hypothetical double perovskite Ca 2 CrMoO 6 . This material was prepared in polycrystalline form by solid state reaction in H 2 /Ar flow. It has been studied by X-ray and neutron powder diffraction (NPD) and magnetic measurements. Ca(Cr 0.5 Mo 0.5 )O 3 crystallizes in the orthorhombic Pbnm (No. 62) space group, with the unit-cell parameters a=5.4110 (4) A, b=5.4795 (5) A, c=7.6938 (6) A. There is a complete disordering of Cr 3+ and Mo 5+ over the B-site of the perovskite, and the (Cr,Mo)O 6 octahedra are tilted by 12.4 o in order to optimize the Ca-O bond lengths. The magnetic susceptibility is characteristic of a ferrimagnetic behavior, with T C =125 K, and a small saturation magnetization at T=5 K, of 0.05 μ B /f.u. - Graphical abstract: Ca(Cr 0.5 Mo 0.5 )O 3 is orthorhombic, Pbnm space group, and exhibits a complete disordering of Cr 3+ and Mo 5+ over the B-site of the perovskite. The magnetic susceptibility is characteristic of a ferrimagnetic behavior, with T C =125 K, and a small saturation magnetization at T=5 K, of 0.05 μ B /f.u

  17. Determination of the calcium species in coal chars by Ca K-edge XANES analysis

    Science.gov (United States)

    Liu, Li-Juan; Liu, Hui-Jun; Cui, Ming-Qi; Hu, Yong-Feng; Zheng, Lei; Zhao, Yi-Dong; Ma, Chen-Yan; Xi, Shi-Bo; Yang, Dong-Liang; Guo, Zhi-Ying; Wang, Jie

    2013-02-01

    Ca-based additives have been widely used as a sulfur adsorbent during coal pyrolysis and gasification. The Ca speciation and evolution during the pyrolysis of coal with Ca additives have attracted great attention. In this paper, Ca species in the coal chars prepared from the pyrolysis of Ca(OH)2 or CaCO3-added coals are studied by using Ca K-edge X-ray absorption near-edge structural spectroscopy. The results demonstrate that Ca(OH)2, CaSO4, CaS and CaO coexist in the Ca(OH)2-added chars, while Ca(OH)2 and CaSO4 are the main species in the Ca(OH)2-added chars. Besides, a carboxyl-bound Ca is also formed during both the pyrolysis for the Ca(OH)2-added and the CaCO3-added coals. A detailed discussion about the Ca speciation is given.

  18. Studies of the effects of TiCl3 in LiBH4/CaH2/TiCl3 reversible hydrogen storage system

    International Nuclear Information System (INIS)

    Liu Dongan; Yang Jun; Ni Jun; Drews, Andy

    2012-01-01

    Highlights: ► We systematically studied the effects of TiCl 3 in LiBH 4 /CaH 2 /TiCl 3 hydrogen storage system. ► It is found that adding 0.25 TiCl 3 produces fully reversible hydrogen absorption and desorption and a lower desorption temperature. ► LiCl experiences four different states, i.e. “formed-solid solution-molten solution-precipitation”, in the whole desorption process of the system. ► The incorporation of LiCl into LiBH 4 forms more viscous molten LiBH 4 ·LiCl, leading to fast kinetics. ► The precipitation and re-incorporation of LiCl into LiBH 4 lead to a fully reversible complex hydrogen storage system. - Abstract: In the present study, the effects of TiCl 3 on desorption kinetics, absorption/desorption reversibility, and related phase transformation processes in LiBH 4 /CaH 2 /TiCl 3 hydrogen storage system was studied systematically by varying its concentration (x = 0, 0.05, 0.15 and 0.25). The results show that LiCl forms during ball milling of 6LiBH 4 /CaH 2 /xTiCl 3 and that as temperature increases, o-LiBH 4 transforms into h-LiBH 4 , into which LiCl incorporates, forming solid solution of LiBH 4 ·LiCl, which melts above 280 °C. Molten LiBH 4 ·LiCl is more viscous than molten LiBH 4 , preventing the clustering of LiBH 4 and the accompanied agglomeration of CaH 2 , and thus preserving the nano-sized phase arrangement formed during ball milling. Above 350 °C, the molten solution LiBH 4 ·LiCl further reacts with CaH 2 , precipitating LiCl. The main hydrogen desorption reaction is between molten LiBH 4 ·LiCl and CaH 2 and not between molten LiBH 4 and CaH 2 . This alters the hydrogen reaction thermodynamics and lowers the hydrogen desorption temperature. In addition, the solid–liquid nano-sized phase arrangement in the nano-composites improves the hydrogen reaction kinetics. The reversible incorporation/precipitation of LiCl at the hydrogen reaction temperature and during temperature cycling makes the 6LiBH 4 /CaH 2 /0.25TiCl 3

  19. Neutron diffraction studies on La2−xDyxCa2xBa2Cu4+2xOz ...

    Indian Academy of Sciences (India)

    Abstract. Structural studies on Dy-substituted La-2125 type superconductors have been carried out by neutron diffraction experiments at room temperature using a monochromatic neutron beam of wavelength (λ) = 1.249 Å. A series of samples with. La2−xDyxCa2xBa2Cu4+2xOz stoichiometric composition, for x = 0.1–0.5, ...

  20. Development and validation of TOF-SIMS and CLSM imaging method for cytotoxicity study of ZnO nanoparticles in HaCaT cells

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Pei-Ling; Chen, Bo-Chia; Gollavelli, Ganesh [Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan (China); Shen, Sin-Yu [Graduate Institute of Medical Science, Taipei Medical University, Taipei 11031, Taiwan (China); Yin, Yu-Sheng; Lei, Shiu-Ling [Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan (China); Jhang, Cian-Ling; Lee, Woan-Ruoh [Department of Dermatology, Taipei Medical University, Taipei 11031, Taiwan (China); Ling, Yong-Chien, E-mail: ycling@mx.nthu.edu.tw [Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan (China); Graduate Institute of Medical Science, Taipei Medical University, Taipei 11031, Taiwan (China)

    2014-07-30

    Highlights: • Assorted material, chemical, and toxicological analysis methods were used to confirm the shape, size, crystalline structure, and aggregation properties of ZnO NPS as well as their dissolution behavior and effect on HaCaT cell viability. • The developed TOF-SIMS and CLSM imaging method for rapid and sensitive study of ZnO NPs in HaCaT cells was validated by comparative and correlative analyses to aforementioned experimental results. • The imaging results demonstrate spatially-resolved cytotoxicity relationship between intracellular ZnO NPs concentration, {sup 40}Ca/{sup 39}K ratio, phosphocholine fragments, and glutathione fragments. CLSM images reveal the localization of ZnO NPs in cytoplasm and nuclei. • The trend of change in TOF-SIMS spectra and images of ZnO NPs treated HaCaT cells demonstrate the possible mode of actions by ZnO NP involves cell membrane disruption, cytotoxic response, and ROS mediated apoptosis. - Abstract: Zinc oxide nanoparticles (ZnO NPs) exhibit novel physiochemical properties and have found increasing use in sunscreen products and cosmetics. The potential toxicity is of increasing concern due to their close association with human skin. A time-of-flight secondary ion mass spectrometry (TOF-SIMS) and confocal laser scanning microscopy (CLSM) imaging method was developed and validated for rapid and sensitive cytotoxicity study of ZnO NPs using human skin equivalent HaCaT cells as a model system. Assorted material, chemical, and toxicological analysis methods were used to confirm their shape, size, crystalline structure, and aggregation properties as well as dissolution behavior and effect on HaCaT cell viability in the presence of various concentrations of ZnO NPs in aqueous media. Comparative and correlative analyses of aforementioned results with TOF-SIMS and CLSM imaging results exhibit reasonable and acceptable outcome. A marked drop in survival rate was observed with 50 μg/ml ZnO NPs. The CLSM images reveal the

  1. Development and validation of TOF-SIMS and CLSM imaging method for cytotoxicity study of ZnO nanoparticles in HaCaT cells

    International Nuclear Information System (INIS)

    Lee, Pei-Ling; Chen, Bo-Chia; Gollavelli, Ganesh; Shen, Sin-Yu; Yin, Yu-Sheng; Lei, Shiu-Ling; Jhang, Cian-Ling; Lee, Woan-Ruoh; Ling, Yong-Chien

    2014-01-01

    Highlights: • Assorted material, chemical, and toxicological analysis methods were used to confirm the shape, size, crystalline structure, and aggregation properties of ZnO NPS as well as their dissolution behavior and effect on HaCaT cell viability. • The developed TOF-SIMS and CLSM imaging method for rapid and sensitive study of ZnO NPs in HaCaT cells was validated by comparative and correlative analyses to aforementioned experimental results. • The imaging results demonstrate spatially-resolved cytotoxicity relationship between intracellular ZnO NPs concentration, 40 Ca/ 39 K ratio, phosphocholine fragments, and glutathione fragments. CLSM images reveal the localization of ZnO NPs in cytoplasm and nuclei. • The trend of change in TOF-SIMS spectra and images of ZnO NPs treated HaCaT cells demonstrate the possible mode of actions by ZnO NP involves cell membrane disruption, cytotoxic response, and ROS mediated apoptosis. - Abstract: Zinc oxide nanoparticles (ZnO NPs) exhibit novel physiochemical properties and have found increasing use in sunscreen products and cosmetics. The potential toxicity is of increasing concern due to their close association with human skin. A time-of-flight secondary ion mass spectrometry (TOF-SIMS) and confocal laser scanning microscopy (CLSM) imaging method was developed and validated for rapid and sensitive cytotoxicity study of ZnO NPs using human skin equivalent HaCaT cells as a model system. Assorted material, chemical, and toxicological analysis methods were used to confirm their shape, size, crystalline structure, and aggregation properties as well as dissolution behavior and effect on HaCaT cell viability in the presence of various concentrations of ZnO NPs in aqueous media. Comparative and correlative analyses of aforementioned results with TOF-SIMS and CLSM imaging results exhibit reasonable and acceptable outcome. A marked drop in survival rate was observed with 50 μg/ml ZnO NPs. The CLSM images reveal the absorption

  2. Impact of seawater [Ca

    NARCIS (Netherlands)

    Mewes, A.; Langer, G.; Thoms, S.; Nehrke, G.; Reichart, G.J.; de Nooijer, L.J.; Bijma, J.

    2015-01-01

    Mg / Ca ratios in foraminiferal tests are routinely used as paleotemperature proxies, but on long timescales, they also hold the potential to reconstruct past seawater Mg / Ca. The impact of both temperature and seawater Mg / Ca on Mg incorporation in Foraminifera has been quantified by a number of

  3. CA-125 blood test

    Science.gov (United States)

    Ovarian cancer - CA-125 test ... CA-125 is a protein that is found more in ovarian cancer cells than in other cells. This ... ovarian cancer . The test is useful if the CA-125 level was high when the cancer was first ...

  4. Expression of calcium channel CaV1.3 in cat spinal cord: light and electron microscopic immunohistochemical study

    DEFF Research Database (Denmark)

    Zhang, Mengliang; Møller, Morten; Broman, Jonas

    2008-01-01

    in the cat spinal cord by light and electron microscopic immunohistochemistry. The results show that Ca(V)1.3-like immunoreactivity is widely distributed in all segments of the spinal cord but that the distribution in the different laminae of the spinal gray matter varies, with the highest density of labeled...... associated with the rough endoplasmic reticulum but some also with the plasma membrane. In dendrites, they were associated with both intracellular organelles, including microtubules and microchondria, and the plasma membrane. These results indicate that significant proportions of the neurons in cat spinal...

  5. Reaction Dynamics and Nuclear Structure Studies of n-Rich Nuclei Around 48Ca via Deep Inelastic Collisions with Heavy-Ions

    International Nuclear Information System (INIS)

    Leoni, S.

    2011-01-01

    The population and γ decay of neutron rich nuclei around 48 Ca has been measured at Legnaro National Laboratory with the PRISMA-CLARA setup, using deep-inelastic collisions on 64 Ni, at 5.9 MeV/A. The reaction properties of the main products are investigated, focusing on total cross-sections and energy integrated angular distributions. Gamma spectroscopy studies are also performed for the most intense transfer channels, making use of angular distributions and polarization measurements to firmly establish spin and parity of the excited states. In the case of 49 Ca candidates for particle-core couplings are investigated and interpreted on basis of lifetime measurements and comparison with model predictions. (author)

  6. A DFT study of the catalytic pyrolysis of benzaldehyde on ZnO, γ-Al2O3, and CaO models.

    Science.gov (United States)

    Cui, Li-Ping; Liu, Jiang-Tao; Liu, Shi-Zhong; Wang, Ming-Fei; Gao, Zhi-Hua; Zuo, Zhi-Jun; Huang, Wei

    2018-02-21

    The catalytic pyrolysis pathways of carbonyl compounds in coal were systematically studied using density functional theory (DFT), with benzaldehyde (C 6 H 5 CHO) employed as a coal-based model compound and ZnO, γ-Al 2 O 3 , and CaO as catalysts. The results show that the products of both pyrolysis and catalytic pyrolysis are C 6 H 6 and CO. However, the presence of any of the catalysts changes the reaction pathway and reduces the energy barrier, indicating that these catalysts promote C 6 H 5 CHO decomposition. Graphical abstract The presence of catalysts changes the reaction pathway and the energy barrier decreases in the order Ea (no catalyst)> Ea (CaO)> Ea (γ-Al 2 O 3 )> Ea (ZnO), indicating that these catalysts promote C 6 H 5 CHO decomposition.

  7. A pilot study of the feasibility of long-term human bone balance during perimenopause using a {sup 41}Ca tracer

    Energy Technology Data Exchange (ETDEWEB)

    Hui, S.K. [Racah Institute of Physics, Hebrew University, Jerusalem 91904 (Israel) and Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota, 420 Delaware Street SE, Mayo Mail Code 494, Minneapolis, MN 55455 (United States)]. E-mail: huixx019@umn.edu; Prior, J. [Deparment of Medicine/Endocrinology, University of British Columbia, Vancouver, B.C., V5Z 1C6 (Canada); Gelbart, Z. [TRIUMF, Vancouver, B.C., V6T2A3 (Canada); Johnson, R.R. [TRIUMF, Vancouver, B.C., V6T2A3 (Canada); Lentle, B.C. [Department of Radiology, University of British Columbia, British Columbia, V8M 1V4 (Canada); Paul, M. [Racah Institute of Physics, Hebrew University, Jerusalem 91904 (Israel)

    2007-06-15

    The mechanisms governing calcium fluxes during bone remodeling processes in perimenopausal women are poorly known. Despite higher, albeit erratic, estradiol levels in perimenopause, spine bone loss is greater than during the first five years past the final menstrual flow when estradiol becomes low. Understanding changes during this dynamic transition are important to prevent fragility fractures in midlife and older women. The exploration of long-lived {sup 41}Ca (T {sub 1/2} = 1.04 x 10{sup 5} yrs) tracer measurements using accelerator mass spectrometry (AMS) leads to the possibility of monitoring bone remodeling balance. With this new technology, we explored a pilot long-term feasibility study of bone health by measuring the {sup 41}Ca trace element in urine for six years from premenopausal to later perimenopausal phases in one midlife woman. We measured bone mineral density in parallel.

  8. Revisiting the I{\\overline {\\bf 1}} structures of high-temperature Ca-rich plagioclase feldspar - a single-crystal neutron and X-ray diffraction study.

    Science.gov (United States)

    Jin, Shiyun; Wang, Xiaoping; Xu, Huifang

    2018-04-01

    The I{\\overline 1} structures of four natural Ca-rich plagioclase feldspars formed at high temperature were analysed using single-crystal neutron and X-ray diffraction. The neutron time-of-flight Laue diffractometer at the ORNL Spallation Neutron Source (Tennessee, USA) combined with a single-crystal X-ray diffraction instrument were able to reveal some new details about these already intensively studied structures. The split oxygen atoms refined from the neutron diffraction data show the underlying mechanism of Ca-Na ordering and the anisotropic P{\\overline 1} ordering along the c-axis. The compositional ranges covered by the samples studied are quite rare for I{\\overline 1} structures. The incommensurately modulated e2 structure of some plagioclase samples can easily be confused with an I{\\overline 1} structure from the diffraction pattern, which puts some previously published I{\\overline 1} structures into question. An incomplete phase diagram for Ca-rich plagioclase feldspar is proposed to explain the rarity of the I{\\overline 1} structure in this compositional range, and a time-temperature-transformation diagram for the composition ∼An 66 is provided accordingly.

  9. Free and Ca-Alginate Beads Immobilized Horseradish Peroxidase for the Removal of Reactive Dyes: an Experimental and Modeling Study.

    Science.gov (United States)

    Farias, Simone; Mayer, Diego A; de Oliveira, Débora; de Souza, Selene M A Guelli U; de Souza, Antônio Augusto Ulson

    2017-08-01

    The aim of this work was to remove the dyes Reactive Blue 221 (RB 221) and Reactive Blue 198 (RB 198) of synthetic effluent using the immobilized enzyme horseradish peroxidase (HRP) in Ca-alginate beads. Experimental parameters affecting the dye removal process such as the effect of pH, temperature, hydrogen peroxide concentration, mass capsules, and reuse were evaluated, and a numerical model of mass transfer was developed. A maximum removal of 93 and 75%, respectively, for the dyes RB 221 and RB 198, at pH 5.5 and temperature of 30 °C, concentration of hydrogen peroxide of 43.75 μM for dye RB 221 and 37.5 μM for the dye of RB 198 was obtained. A removal reaction of 180 min for RB 221 and 240 min for RB 198 was observed. Three reuse cycles of use of immobilized enzyme were achieved for both dyes. The numerical model proposed led to a good fit compared to experimental data. The HRP enzyme immobilized in Ca-alginate capsules showed a great potential for biotechnological applications, especially for the removal of reactive dyes.

  10. Application of cytoplasmic Ca2+ fluorescence imaging techniques to study the molecular mechanisms of exercise-induced fatigue eliminated by Chinese medicine ginseng extract

    Science.gov (United States)

    Liu, Yi; Zhao, Yanping; Zhang, Heming; Liu, Songhao

    2009-11-01

    The exercise-induced fatigue eliminated by Chinese medicine offers advantages including good efficiency and smaller side-effects, however, the exact mechanisms have not been classified. A lot of literatures indicated the cytosolic free Ca2+ concentrations of skeletal muscle cells increased significantly during exercise-induced fatigue. This study is aimed to establish a rat skeletal muscle cell model of exercise-induced fatigue. We applied cytoplasmic Ca2+ fluorescence imaging techniques to study the molecular mechanisms of exercise-induced fatigue eliminated by Chinese medicine ginseng extract. In our research, the muscle tissues from the newborn 3 days rats were taken out and digested into cells. The cells were randomly divided into the ginseng extract group and the control group. The cells from the two groups were cultured in the medium respectively added 2mg/ml ginseng extract and 2mg/ml D-hanks solution. After differentiating into myotubes, the two groups of cells treated with a fluorescent probe Fluo-3 AM were put on the confocal microscope and the fluorescence intensity of cells pre- and post- stimulation with dexamethasone were detected. It was found that cytoplasmic Ca2+ concentrations of the two groups of cells both increased post-stimulation, however, the increasing amplitude of fluorescence intensity of the ginseng extract group was significantly lower than that of the control group. In conclusion, stimulating the cells with dexamethasone is a kind of workable cell models of exercise-induced fatigue, and the molecular mechanisms of exercise-induced fatigue eliminated by ginseng extract may be connected to regulatating cytosolic free Ca2+ concentrations.

  11. Ca2+ cycling in heart cells from ground squirrels: adaptive strategies for intracellular Ca2+ homeostasis.

    Directory of Open Access Journals (Sweden)

    Xiao-Chen Li

    Full Text Available Heart tissues from hibernating mammals, such as ground squirrels, are able to endure hypothermia, hypoxia and other extreme insulting factors that are fatal for human and nonhibernating mammals. This study was designed to understand adaptive mechanisms involved in intracellular Ca(2+ homeostasis in cardiomyocytes from the mammalian hibernator, ground squirrel, compared to rat. Electrophysiological and confocal imaging experiments showed that the voltage-dependence of L-type Ca(2+ current (I(Ca was shifted to higher potentials in ventricular myocytes from ground squirrels vs. rats. The elevated threshold of I(Ca did not compromise the Ca(2+-induced Ca(2+ release, because a higher depolarization rate and a longer duration of action potential compensated the voltage shift of I(Ca. Both the caffeine-sensitive and caffeine-resistant components of cytosolic Ca(2+ removal were more rapid in ground squirrels. Ca(2+ sparks in ground squirrels exhibited larger amplitude/size and much lower frequency than in rats. Due to the high I(Ca threshold, low SR Ca(2+ leak and rapid cytosolic Ca(2+ clearance, heart cells from ground squirrels exhibited better capability in maintaining intracellular Ca(2+ homeostasis than those from rats and other nonhibernating mammals. These findings not only reveal adaptive mechanisms of hibernation, but also provide novel strategies against Ca(2+ overload-related heart diseases.

  12. Study of variation in thermal width of nematic and induced smectic ordering phase of citric acid (CA) and 4-heptyloxybenzoic acid (7OBA) hydrogen bonded liquid crystal complexes

    Science.gov (United States)

    Sundaram, S.; Jayaprakasam, R.; Praveena, R.; Rajasekaran, T. R.; Senthil, T. S.; Vijayakumar, V. N.

    2018-01-01

    Hydrogen-bonded liquid crystals (HBLCs) have been derived from nonmesogenic citric acid (CA) and mesogenic 4-heptyloxybenzoic acid (7OBA) yielding a highly ordered smectic C (Sm C) phase along with the new smectic X (Sm X) phase which has been identified as fingerprint-type texture. Optical (polarizing optical microscopy), thermal (differential scanning calorimetry) and structural (Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy) properties are studied. A noteworthy observation is that the intermolecular H-bond (between CA and 7OBA) influences on its melting point and clearing temperature of the HBLCs which exhibits lower value than those of the individual compounds. A typical extended mesophase region has been observed in the present complex while varying the mixture ratio (1:1 to 1:3) than those of individual compounds. The change in the ratio of the mesogenic compound in the mixture alters thermal properties such as enthalpy value and thermal span width in nematic (N) region of HBLC complex. Optical tilt angle measurement of CA+7OBA in Sm C phase has been discussed to identify the molecular position in the mesophase.

  13. Thermoluminescence and photoluminescence study of Ba{sub 0.97}Ca{sub 0.03}SO{sub 4} : Eu

    Energy Technology Data Exchange (ETDEWEB)

    Lochab, S P [Inter-University Accelerator Centre, Aruna Asaf Ali Marg, New Delhi-110067 (India); Sahare, P D [Department of Physics and Astrophysics, University of Delhi, Delhi-110007 (India); Chauhan, R S [Department of Physics, RBS College, BR Ambedkar University, Agra-282002 (India); Salah, Numan [Department of Physics and Astrophysics, University of Delhi, Delhi-110007 (India); Pandey, A [Department of Physics, Sri Venkateswara College, University of Delhi, Benito Juarez Road, Dhaula Kuan, New Delhi-110021 (India)

    2006-05-07

    A highly sensitive thermoluminescence (TL) phosphor based on Ba{sub 1-x}Ca{sub x}SO{sub 4} : Eu (0 {<=} x {<=} 1) has been prepared using the chemical co-precipitation technique. It has been found that the TL sensitivity of the material changes on varying the value of x with the maximum coming at x 0.03. For this value of x the sensitivity is even more than that of the commercially available phosphor CaSO{sub 4} : Dy ({approx}2.3 times more). Photoluminescence (PL) and XRD studies of the material show that the maximum TL sensitivity obtained at x = 0.03 is due to the conversion of Eu{sup 3+} to Eu{sup 2+} being highest in this case. Moreover, the phosphor Ba{sub 0.97}Ca{sub 0.03}SO{sub 4} : Eu has a constant glow curve shape and a linear gamma-ray dose response over the range 0.1-50 Gy which makes it suitable for radiation dosimetry.

  14. Comparative study of perovskite-type scintillator materials CsCaI3 and KCaI3 via first-principles calculations

    Science.gov (United States)

    Kang, Byungkyun; Feng, Qingguo; Biswas, Koushik

    2018-02-01

    Several members of a large family of perovskite-like halides with a common chemical formula, ABX3 (A  =  monovalent, B  =  divalent, and X  =  halogen ion), are being investigated for their interesting properties and potential technological applications. CsCaI3 and KCaI3 are two such ionic compounds who are of interest in the quest for superior and cost-effective alternatives to NaI or CsI based scintillators. They are the subject of this first-principles based computational study. Both are wide-gap materials having primarily I 5p and Ca 3d characters near the valence and conduction band edges, respectively. Although built from [CaI6] octahedral motifs, structural differences between the two compounds is reflected in anisotropic electron effective mass and distinctive formation and migration of self-trapped holes. We discuss these properties as they relate to scintillation decay and proportional light yield.

  15. Performance of ROMA based on Architect CA 125 II and HE4 values in Chinese women presenting with a pelvic mass: A multicenter prospective study.

    Science.gov (United States)

    Shen, Fengxian; Lu, Shiming; Peng, Yibing; Yang, Fan; Chen, Yan; Lin, Yingying; Yang, Chen; Wu, Li; Li, Huijun; Zheng, Yijie

    2017-08-01

    We evaluated the performance of human epididymis protein 4 (HE4), cancer antigen 125(CA 125) and Risk of Ovarian Malignancy Algorithm (ROMA) in distinguishing between benign and malignant pelvic masses in Chinese women. From April to December 2012, women with a pelvic mass scheduled to have surgery were enrolled in a prospective, multi-center study conducted in 5 different regions in China. Preoperative serum concentrations of HE4 and CA 125 were examined and ROMA was calculated. A total of 684 women with a pelvic mass were included, of which 482 were diagnosed with benign conditions and 202 were diagnosed with malignant ovarian tumors. At cutoffs of 7.4% and 25.3% for ROMA, the sensitivities and specificities were 85.6% and 81.7% for all patients, 85.7% and 81.5% for premenopausal women, and 85.6% and 83.9% for postmenopausal women, respectively. The ROC-AUC of ROMA was significantly better than that of HE4 (P=0.0003) or CA 125 (P<0.0001) for all malignant diseases (including EOC, Non-EOC, LMP, metastases and other pelvic malignancy with no involvement of the ovaries) compared with benign diseases for all patients. We demonstrated the efficiency of ROMA in the distinction of ovarian cancers from benign disease in a multiple-regions Chinese population, especially in premenopausal women. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Evaluation of Serum CEA, CA19-9, CA72-4, CA125 and Ferritin as Diagnostic Markers and Factors of Clinical Parameters for Colorectal Cancer.

    Science.gov (United States)

    Gao, Yanfeng; Wang, Jinping; Zhou, Yue; Sheng, Sen; Qian, Steven Y; Huo, Xiongwei

    2018-02-09

    Blood-based protein biomarkers have recently shown as simpler diagnostic modalities for colorectal cancer, while their association with clinical pathological characteristics is largely unknown. In this study, we not only examined the sensitivity and reliability of single/multiple serum markers for diagnosis, but also assessed their connection with pathological parameters from a total of 279 colorectal cancer patients. Our study shown that glycoprotein carcinoembryonic antigen (CEA) owns the highest sensitivity among single marker in the order of CEA > cancer antigen 72-4 (CA72-4) > cancer antigen 19-9 9 (CA19-9) > ferritin > cancer antigen 125 (CA125), while the most sensitive combined-markers for two to five were: CEA + CA72-4; CEA + CA72-4 + CA125; CEA + CA19-9 + CA72-4 + CA125; and CEA + CA19-9 + CA72-4 + CA125 + ferritin, respectively. We also demonstrated that patients who had positive preoperative serum CEA, CA19-9, or CA72-4 were more likely with lymph node invasion, positive CA125 were prone to have vascular invasion, and positive CEA or CA125 were correlated with perineural invasion. In addition, positive CA19-9, CA72-4, or CA125 was associated with poorly differentiated tumor, while CEA, CA19-9, CA72-4, CA125 levels were positively correlated with pathological tumor-node-metastasis stages. We here conclude that combined serum markers can be used to not only diagnose colorectal cancer, but also appraise the tumor status for guiding treatment, evaluation of curative effect, and prognosis of patients.

  17. Model study of ATP and ADP buffering, transport of Ca(2+) and Mg(2+), and regulation of ion pumps in ventricular myocyte

    Science.gov (United States)

    Michailova, A.; McCulloch, A.

    2001-01-01

    We extended the model of the ventricular myocyte by Winslow et al. (Circ. Res 1999, 84:571-586) by incorporating equations for Ca(2+) and Mg(2+) buffering and transport by ATP and ADP and equations for MgATP regulation of ion transporters (Na(+)-K(+) pump, sarcolemmal and sarcoplasmic Ca(2+) pumps). The results indicate that, under normal conditions, Ca(2+) binding by low-affinity ATP and diffusion of CaATP may affect the amplitude and time course of intracellular Ca(2+) signals. The model also suggests that a fall in ATP/ADP ratio significantly reduces sarcoplasmic Ca(2+) content, increases diastolic Ca(2+), lowers systolic Ca(2+), increases Ca(2+) influx through L-type channels, and decreases the efficiency of the Na(+)/Ca(2+) exchanger in extruding Ca(2+) during periodic voltage-clamp stimulation. The analysis suggests that the most important reason for these changes during metabolic inhibition is the down-regulation of the sarcoplasmic Ca(2+)-ATPase pump by reduced diastolic MgATP levels. High Ca(2+) concentrations developed near the membrane might have a greater influence on Mg(2+), ATP, and ADP concentrations than that of the lower Ca(2+) concentrations in the bulk myoplasm. The model predictions are in general agreement with experimental observations measured under normal and pathological conditions.

  18. Intelligent Design, A Young Universe, Astrology, UFO'S, and More: A Guide for Those Involved with IYA on Tackling Pseudo-science

    Science.gov (United States)

    Fraknoi, Andrew; Bobrowsky, M.; Thaller, M.; Plait, P.

    2008-05-01

    During IYA educators and scientists will interact with the public in many ways. There will likely be public questions at IYA events about pseudo-scientific topics. While the particular pseudo-sciences that are in vogue change with time, astronomical pseudo-science includes creationism, intelligent design, astrology, UFO's as extra-terrestrial spaceships, selling star names, the "face" on Mars, the claim that the moon landings were a hoax, etc. We cover information, techniques, resources, and activities for responding sensitively to such claims and for explaining the nature of science. Whether you do programs in a formal classroom, a community setting, a museum, or on the radio, you will need this kind of arsenal of critical-thinking responses for these topics when you face the public. Attendees will receive a resource guide for responding to pseudo-science claims. One of the frequently heard attacks on science deals with "alternatives to evolution" (intelligent design and various forms of creationism). While some think this is a matter with which only biologists need to be concerned, some of the same arguments used against biological evolution are invoked to argue against our understanding of the age of the earth and the universe. We will provide background information on and responses to these ideas, particularly as they concern attacks on cosmology and cosmic evolution. We will also discuss how such questions will give IYA presenters an opportunity to engage the public in discussions about the scientific method and worldview. We will see that some of the agendas and issues we face are not that different from what Galileo faced 400 years ago.

  19. Neutron Diffraction Studies on La2-xDyxCa2xBa2Cu4+2xOz Superconductors

    OpenAIRE

    Rayaprol, S.; Parmar, Rohini; Kuberkar, D. G.; Chakraborty, Keka R.; Krishna, P. S. R.; Ramanadham, M.

    2004-01-01

    Structural studies on Dy-substituted La-2125 type superconductors have been carried out by neutron diffraction experiments at room temperature using a monochromatic neutron beam of wavelength lambda = 1.249 Angstroms. A series of samples with La2-xDyxCa2xBa2Cu4+2xOz stoichiometric composition, for x = 0.1 - 0.5, have been studied for their structural properties. A tetragonal Y-123 unit cell was taken as the starting model for the Rietveld analysis. All the samples fit into the starting model,...

  20. Bioactive Natural Product and Superacid Chemistry for Lead Compound Identification: A Case Study of Selective hCA III and L-Type Ca2+ Current Inhibitors for Hypotensive Agent Discovery

    Directory of Open Access Journals (Sweden)

    Hélène Carreyre

    2017-05-01

    Full Text Available Dodoneine (Ddn is one of the active compounds identified from Agelanthus dodoneifolius, which is a medicinal plant used in African pharmacopeia and traditional medicine for the treatment of hypertension. In the context of a scientific program aiming at discovering new hypotensive agents through the original combination of natural product discovery and superacid chemistry diversification, and after evidencing dodoneine’s vasorelaxant effect on rat aorta, superacid modifications allowed us to generate original analogues which showed selective human carbonic anhydrase III (hCA III and L-type Ca2+ current inhibition. These derivatives can now be considered as new lead compounds for vasorelaxant therapeutics targeting these two proteins.

  1. Luminescence study of Dy or Ce activated LiCaBO3 phosphor for γ-ray and C5+ ion beam irradiation.

    Science.gov (United States)

    Oza, Abha H; Dhoble, N S; Lochab, S P; Dhoble, S J

    2015-11-01

    The photoluminescence and thermoluminescence characteristics of rare earths (Dy or Ce) activated LiCaBO3 phosphors have been studied. Phosphors were synthesized by modified solid state synthesis. The phosphors were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), photoluminescence (PL) and thermoluminescence (TL) for structural, morphological and luminescence studies. Dy(3+) activated LiCaBO3 shows emission at 486 and 577 nm due to (4) F9/2 →(6) H15/2 and (4) F9/2 → (6) H13/2 transition, respectively, whereas the PL emission spectra of Ce(3+) activated LiCaBO3 phosphor shows a broad band peaking at 432 nm, which is due to the transition from 5d level to the ground state of the Ce(3+) ion. The thermoluminescence study was also carried out for both these phosphors for γ-ray irradiation and carbon beam irradiation. Linearity was studied for a 0.4-3.1 Rad dose γ-rays. Linear behaviour over this dose range was observed. Gamma ray-irradiated phosphors were shown to be negligible fading upon storage. All the samples were also studied for 75 MeV C(5+) ion beam exposure in the range of 3.75 × 10(12) - 7.5 × 10(13) ion cm(-2) fluence. In addition to this, trapping parameters of all the samples were also calculated using Chen's peak shape method. Copyright © 2015 John Wiley & Sons, Ltd.

  2. Study of the structural and electrical behavior of Bi(Mg,TiO3 modified (Ba,CaTiO3 ceramics

    Directory of Open Access Journals (Sweden)

    Md. Kashif Shamim

    2016-12-01

    Full Text Available The ability of BaTiO3 to form solid solutions with different dopants (both iso- and aliovalent makes it versatile for various applications. In the present study, (Ba,CaTiO3 (BCT is modified with Bi(MgTiO3 (BMT in search for new lead-free ferroelectric material and improve their properties. For this purpose, BCT acts as a main base material and BMT acts as a modifier to fabricate a multifunctional material. In this study, we report the structural and electrical properties of lead free piezo-ceramics (1−x(Ba0.8Ca0.2TiO3–xBi(Mg0.5Ti0.5O3 with x=0.2, 0.4, 0.5 prepared by solid-state sintering technique. Single perovskite phase with tetragonal structure is obtained for all the compositions, which is reconfirmed by the Raman Spectroscopic study. Dielectric study confirm the temperature stable behavior of the dielectric permittivity values above 300∘C. The dielectric constant value decreases with increase in BMT doping content. Impedance Spectroscopic study confirms non-Debye type dielectric relaxation in the specimen. The Nyquist plot and conductivity studies show the negative temperature coefficient of resistance behavior (NTCR of the samples.

  3. crdi.ca

    International Development Research Centre (IDRC) Digital Library (Canada)

    et des enfants d'Afrique. INITIATIVE CONCERTÉE. Innovation pour la santé des mères et des enfants d'Afrique. Centre de recherches pour le développement international. CP Box 8500 Ottawa ON Canada K1G 3H9. Téléphone : +1 613 236 6163 • Télécopieur : +1 613 657 7749 ismea@crdi.ca | www.crdi.ca/ismea crdi.ca.

  4. INTRACELLULAR Ca2+ HOMEOSTASIS

    Directory of Open Access Journals (Sweden)

    Shahdevi Nandar Kurniawan

    2015-01-01

    Full Text Available Ca2+ signaling functions to regulate many cellular processes. Dynamics of Ca2+ signaling or homeostasis is regulated by the interaction between ON and OFF reactions that control Ca2+ flux in both the plasma membrane and internal organelles such as the endoplasmic reticulum (ER and mitochondria. External stimuli activate the ON reactions, which include Ca2+ into the cytoplasm either through channels in the plasma membrane or from internal storage like in ER. Most of the cells utilize both channels/sources, butthere area few cells using an external or internal source to control certain processes. Most of the Ca2+ entering the cytoplasm adsorbed to the buffer, while a smaller part activate effect or to stimulate cellular processes. Reaction OFF is pumping of cytoplasmic Ca2+ using a combination mechanism of mitochondrial and others. Changes in Ca2+ signal has been detected in various tissues isolated from animals induced into diabetes as well as patients with diabetes. Ca2+ signal interference is also found in sensory neurons of experimental animals with diabetes. Ca2+ signaling is one of the main signaling systems in the cell.

  5. Study of a generalized birks formula for the scintillation response of a CaMoO4 crystal

    Science.gov (United States)

    Lee, J. Y.; Kim, H. J.; Kang, Sang Jun; Lee, M. H.

    2017-12-01

    We have investigated the scintillation characteristics of CaMoO4 (CMO) crystals by using a gamma source and various internal alpha sources. A 137Cs source with 662-keV gamma-rays was used for the gamma-quanta light yield calibration. Internal radioactive contaminations provided alpha particles with different energies from 5.41 to 7.88 MeV. We developed a C++ program based on the ROOT package for the fitting of parameters in a generalized Birks semi-empirical formula by combining the experimental and the simulation data. Results for the fitted Birks parameters are k b1 = 3.3 × 10 -3 (g/MeVcm2) for the 1st parameter and k b2 = 7.9 × 10 -5 (g/MeVcm2)2 for the 2nd parameter. The χ2/n.d.f. (Number of Degree of Freedom) is calculated as 0.1/4. We were able to estimate the 238U and 234U contaminations in a CMO crystal by using the generalized Birks semi-empirical formula.

  6. Experimental study of a novel CaCl{sub 2}/expanded graphite-NH{sub 3} adsorption refrigerator

    Energy Technology Data Exchange (ETDEWEB)

    Li, S.L.; Xia, Z.Z.; Wu, J.Y.; Li, J.; Wang, R.Z.; Wang, L.W. [Institute of Refrigeration and Cryogenics, Shanghai Jiao Tong University, Shanghai 200030 (China)

    2010-01-15

    A novel CaCl{sub 2}/expanded graphite-NH{sub 3} adsorption refrigerator is developed and tested. Only three valves are installed in this refrigerator and they all work at the same positive pressure condition, so the operating reliability of the refrigerator is greatly improved. The experimental results show that the refrigerating power Q{sub CP}, COP, SCP, electricity COP{sub El}, and volume refrigerating density Q{sub CP-V} of the refrigerator are 11.4 kW, 0.27, 422.2 W/kg, 32.6 and 57 kW/m{sup 3}, respectively, under the following conditions: the temperature of heating vapor is from 120 C to 140.3 C, the cooling water temperature is 25 C, the evaporation temperature is -15 C, the heating/cooling time is 25 min including 45 s mass recovery time. The SCP and volume refrigerating density of this refrigerator are about 1.8 times and 1.5 times that of the maximum of the former test results by other researchers. (author)

  7. A detailed study of the hysteresis in La0.67Ca0.33MnO3

    DEFF Research Database (Denmark)

    Neves Bez, Henrique; Nielsen, Kaspar Kirstein; Smith, Anders

    2016-01-01

    We report a thorough study of the thermal hysteretic behaviour of a single phase sample of the magnetocaloric material La0.67Ca0.33MnO3. Previous reports in the literature have variously found hysteretic and non-hysteretic behaviour. We show the importance of measuring under carefully defined...... heating and cooling procedures. Careful analysis of the specific heat, measured at five different temperature ramp rates, and the magnetic entropy change indicates that there is no observable hysteresis, even though the behaviour of both quantities is consistent with a first-order phase transition. We...

  8. Morin-like spin canting in the magnetic CaFe{sub 5}O{sub 7} ferrite: A combined neutron and Mössbauer study

    Energy Technology Data Exchange (ETDEWEB)

    Delacotte, C.; Bréard, Y.; Caignaert, V.; Hardy, V. [Laboratoire CRISMAT ENSICAEN UMR CNRS 6508, 6 Boulevard du Maréchal Juin, 14050 Caen Cedex 04 (France); Greneche, J.M. [Institut des Molécules et Matériaux du Mans, IMMM UMR CNRS 6283, Avenue Olivier Messiaen, 72085 Le Mans (France); Hébert, S. [Laboratoire CRISMAT ENSICAEN UMR CNRS 6508, 6 Boulevard du Maréchal Juin, 14050 Caen Cedex 04 (France); Suard, E. [Institut Laue-Langevin, 71 avenue des Martyrs, 38042 Grenoble Cedex 9 (France); Pelloquin, D. [Laboratoire CRISMAT ENSICAEN UMR CNRS 6508, 6 Boulevard du Maréchal Juin, 14050 Caen Cedex 04 (France)

    2017-03-15

    Magnetic structure of CaFe{sub 5}O{sub 7} ferrite has been studied jointly from neutron powder diffraction data and spectroscopic Mössbauer measurements in the thermal range from 5 to 500 K. This coupled work highlights three distinct magnetic domains around two specific temperatures: T{sub M}=125 K and T{sub N}=360 K. The latter corroborates the structural monoclinic-orthorhombic transition previously reported by transmission electron microscopy techniques and X-ray thermodiffractometry. Complementary heat capacity measurements have confirmed this first order transition with a sharp peak at 360 K. Interestingly, this large study has revealed a second magnetic transition associated to a spin rotation at 125 K similar to this one reported by Morin in α-Fe{sub 2}O{sub 3} hematite at T{sub M}=260 K. - Graphical abstract: Magnetic structure of CaFe{sub 5}O{sub 7} ferrite has been studied jointly from neutron powder diffraction data and spectroscopic Mössbauer measurements in the thermal range from 5 to 500 K. This coupled work highlights three distinct magnetic domains around two specific temperatures: T{sub M}=125 K and T{sub N}=360 K. Interestingly, this large study has revealed a magnetic transition associated to a spin rotation at 125 K similar to this one reported by Morin in α-Fe{sub 2}O{sub 3} hematite at T{sub M}=260 K.

  9. The local structure of Ca-Na pyroxenes. 2-Xanes studies at the Mg and A1 K edges

    International Nuclear Information System (INIS)

    Mottana, A.; Cibin, G.; Paris, E.; Giuli, G.; Florence Univ., Florence

    1999-01-01

    X-ray absorption spectra at the Mg and A1 K edges have been recorded on synthetic endmember diopside (Di) and jadeite (Jd) and on a series of natural Fe-poor Ca-Na clinopyroxenes compositionally straddling the Jd-Di join. The spectra of C2/c members of the series (C-omphacites) are different from having P2/n symmetry (P-omphacites). Differences can be explained by theoretical spectra calculated via the multiple-scattering formalism on atomic clusters with at least 89 atoms, extending to a. 0.62 nm away from the Mg viz. A1 absorber: Xanes detects in these systems medium- rather than short-range order-disorder relationships. Near-edge features of C-omphacites reflect the single-type of octahedral arrangement of the back scattering nearest-neighbours (six O atoms) around the absorber (Mg resp. A1) at the centre of the cluster (site M1). Others arise again from medium-range order. P-omphacites show more complicated spectra than C-omphacites. Their additional features reflect the increased local disorder around the probed atom (Mg resp. A1) induced by the two alternative M1, M11 configurations of the six O atoms forming the first co-ordination spheres. Mg and A1 are confirmed to be preferentially partitioned in the M1 resp. M11 site of the P-omphacite crystal structure, however never exclusively, but in a ratio close to 85:15 (plus or minus 10%) that implies a certain degree of local disorder. Changes in the relative heights of some prominent features are more evident in the A1 than in the Mg K-edge spectra. They are diagnostic to qualitatively distinguish C-from P-omphacites

  10. The local structure of Ca-Na pyroxenes. 2-Xanes studies at the Mg and A1 K edges

    Energy Technology Data Exchange (ETDEWEB)

    Mottana, A. [Rome Univ. Roma Tre, Rome (Italy). Dipt. di Scienze Geologiche; Murata, T. [Kyoto University of Education, Kyoto (Japan). Dept. of Physics; Marcelli, A. [Istituto Nazionale di Fisica Nucleare, Frascati, RM (Italy). Laboratori Nazionali di Frascati; Wu, Z.Y. [Istituto Nazionale di Fisica Nucleare, Frascati, RM (Italy). Laboratori Nazionali di Frascati]|[Laboratoire Piere Suee, Gif-sur Yvette Cedex, (France); Cibin, G. [Istituto Nazionale di Fisica Nucleare, Frascati, RM (Italy). Laboratori Nazionali di Frascati; Paris, E. [Camerino Univ., Camerino, MC (Italy). Dipt. di Scienze della Terra; Giuli, G. [Camerino Univ., Camerino, MC (Italy). Dipt. di Scienze della Terra]|[Florence Univ., Florence (Italy). Dipt. di Scienze della Terra

    1999-07-01

    X-ray absorption spectra at the Mg and A1 K edges have been recorded on synthetic end member diopside (Di) and jadeite (Jd) and on a series of natural Fe-poor Ca-Na clinopyroxenes compositionally straddling the Jd-Di join. The spectra of C2/c members of the series (C-omphacites) are different from having P2/n symmetry (P-omphacites). Differences can be explained by theoretical spectra calculated via the multiple-scattering formalism on atomic clusters with at least 89 atoms, extending to a. 0.62 nm away from the Mg viz. A1 absorber: Xanes detects in these systems medium- rather than short-range order-disorder relationships. Near-edge features of C-omphacites reflect the single-type of octahedral arrangement of the back scattering nearest-neighbours (six O atoms) around the absorber (Mg resp. A1) at the centre of the cluster (site M1). Others arise again from medium-range order. P-omphacites show more complicated spectra than C-omphacites. Their additional features reflect the increased local disorder around the probed atom (Mg resp. A1) induced by the two alternative M1, M11 configurations of the six O atoms forming the first co-ordination spheres. Mg and A1 are confirmed to be preferentially partitioned in the M1 resp. M11 site of the P-omphacite crystal structure, however never exclusively, but in a ratio close to 85:15 (plus or minus 10%) that implies a certain degree of local disorder. Changes in the relative heights of some prominent features are more evident in the A1 than in the Mg K-edge spectra. They are diagnostic to qualitatively distinguish C-from P-omphacites.

  11. The local structure of Ca{sub N}a pyroxenes. I. XANES study at the Na K-edge

    Energy Technology Data Exchange (ETDEWEB)

    Mottana, Annibale [Rome, Univ. III (Italy). Dipt. di Scienze Geologiche; Murata, T. [Kyoto, Univ. of Education (Japan). Dept. of Physics; Wu, Ziyu; Marcelli, Augusto [INFN, Frascati (Italy). Laboratori Nazionali di Frascati; Paris, E. [Camerino, Univ. (Italy). Dipt. di Scienze della Terra

    1996-07-01

    X-ray absorption Na K-edge spectra have been recorded on synthetic end member jadeite and on a series of natural Ca-Na pyroxenes compositionally straddling the Jd-Di. The disordered C2/c members of the series are systematically different from the ordered P2/n members. These differences can be interpreted and explained by comparing the experimental spectra with theoretical spectra. These have been calculated by the multiple-scattering formalism from the atomic positional parameters determined by single-crystal X-ray diffraction structure refinement on the same samples. In the full multiple scattering region of the spectrum (1075 to 1095 eV) C-pyroxenes exhibit three features which reflect the 6-2 configuration of the O back-scattering atoms around the Na absorber located at the center of the cluster (site M2 of the jadeite structure). P-pyroxenes show more complicated spectra in which at least four features can be recognized; they reflect the two types of the configuration (6-2 and 4-2-2) of the oxygens around Na in the two independent M2 and M21 eight-fold coordinated sites of the omphacite structure. A weak, sometimes poorly resolved peak at 1079 eV diagnostic and discriminates C- from P-pyroxenes. The Garnet Ridge C2/c impure jadeite exhibits a spectrum which is intermediate between those of jadeite and omphacite. The Hedin-Lundqist potential proves best for these insulating materials and allows multiple-scattering calculations agreeing well with experiments. The assessment of the local electronic properties of compositionally and structurally complex minerals such as clinopyroxenes is thus enhanced.

  12. Coupled Ca2+/H+ transport by cytoplasmic buffers regulates local Ca2+ and H+ ion signaling.

    Science.gov (United States)

    Swietach, Pawel; Youm, Jae-Boum; Saegusa, Noriko; Leem, Chae-Hun; Spitzer, Kenneth W; Vaughan-Jones, Richard D

    2013-05-28

    Ca(2+) signaling regulates cell function. This is subject to modulation by H(+) ions that are universal end-products of metabolism. Due to slow diffusion and common buffers, changes in cytoplasmic [Ca(2+)] ([Ca(2+)]i) or [H(+)] ([H(+)]i) can become compartmentalized, leading potentially to complex spatial Ca(2+)/H(+) coupling. This was studied by fluorescence imaging of cardiac myocytes. An increase in [H(+)]i, produced by superfusion of acetate (salt of membrane-permeant weak acid), evoked a [Ca(2+)]i rise, independent of sarcolemmal Ca(2+) influx or release from mitochondria, sarcoplasmic reticulum, or acidic stores. Photolytic H(+) uncaging from 2-nitrobenzaldehyde also raised [Ca(2+)]i, and the yield was reduced following inhibition of glycolysis or mitochondrial respiration. H(+) uncaging into buffer mixtures in vitro demonstrated that Ca(2+) unloading from proteins, histidyl dipeptides (HDPs; e.g., carnosine), and ATP can underlie the H(+)-evoked [Ca(2+)]i rise. Raising [H(+)]i tonically at one end of a myocyte evoked a local [Ca(2+)]i rise in the acidic microdomain, which did not dissipate. The result is consistent with uphill Ca(2+) transport into the acidic zone via Ca(2+)/H(+) exchange on diffusible HDPs and ATP molecules, energized by the [H(+)]i gradient. Ca(2+) recruitment to a localized acid microdomain was greatly reduced during intracellular Mg(2+) overload or by ATP depletion, maneuvers that reduce the Ca(2+)-carrying capacity of HDPs. Cytoplasmic HDPs and ATP underlie spatial Ca(2+)/H(+) coupling in the cardiac myocyte by providing ion exchange and transport on common buffer sites. Given the abundance of cellular HDPs and ATP, spatial Ca(2+)/H(+) coupling is likely to be of general importance in cell signaling.

  13. Scenario prediction of emerging coastal city using CA modeling under different environmental conditions: a case study of Lingang New City, China.

    Science.gov (United States)

    Feng, Yongjiu; Liu, Yan

    2016-09-01

    The world's coastal regions are experiencing rapid urbanization coupled with increased risk of ecological damage and storm surge related to global climate and sea level rising. This urban development issue is particularly important in China, where many emerging coastal cities are being developed. Lingang New City, southeast of Shanghai, is an excellent example of a coastal city that is increasingly vulnerable to environmental change. Sustainable urban development requires planning that classifies and allocates coastal lands using objective procedures that incorporate changing environmental conditions. In this paper, we applied cellular automata (CA) modeling based on self-adaptive genetic algorithm (SAGA) to predict future scenarios and explore sustainable urban development options for Lingang. The CA model was calibrated using the 2005 initial status, 2015 final status, and a set of spatial variables. We implemented specific ecological and environmental conditions as spatial constraints for the model and predicted four 2030 scenarios: (a) an urban planning-oriented Plan Scenario; (b) an ecosystem protection-oriented Eco Scenario; (c) a storm surge-affected Storm Scenario; and (d) a scenario incorporating both ecosystem protection and the effects of storm surge, called the Ecostorm Scenario. The Plan Scenario has been taken as the baseline, with the Lingang urban area increasing from 45.8 km(2) in 2015 to 66.8 km(2) in 2030, accounting for 23.9 % of the entire study area. The simulated urban land size of the Plan Scenario in 2030 was taken as the target to accommodate the projected population increase in this city, which was then applied in the remaining three development scenarios. We used CA modeling to reallocate the urban cells to other unconstrained areas in response to changing spatial constraints. Our predictions should be helpful not only in assessing and adjusting the urban planning schemes for Lingang but also for evaluating urban planning in coastal

  14. A Functional Study of Mutations in K+-dependent Na+-Ca2+ Exchangers Associated with Amelogenesis Imperfecta and Non-syndromic Oculocutaneous Albinism.

    Science.gov (United States)

    Jalloul, Ali H; Rogasevskaia, Tatiana P; Szerencsei, Robert T; Schnetkamp, Paul P M

    2016-06-17

    K(+)-dependent Na(+)/Ca(2+) exchangers belong to the solute carrier 24 (SLC24A1-5) gene family of membrane transporters. Five different gene products (NCKX1-5) have been identified in humans, which play key roles in biological processes including vision, olfaction, and skin pigmentation. NCKXs are bi-directional membrane transporters that transport 1 Ca(2+)+K(+) ions in exchange for 4 Na(+) ions. Recent studies have linked mutations in the SLC24A4 (NCKX4) and SLC24A5 (NCKX5) genes to amylogenesis imperfecta (AI) and non-syndromic oculocutaneous albinism (OCA6), respectively. Here, we introduced mutations found in patients with AI and OCA6 into human SLC24A4 (NCKX4) cDNA leading to single residue substitutions in the mutant NCKX4 proteins. We measured NCKX-mediated Ca(2+) transport activity of WT and mutant NCKX4 proteins expressed in HEK293 cells. Three mutant NCKX4 cDNAs represent mutations found in the SCL24A4 gene and three represent mutations found in the SCL24A5 gene involving residues conserved between NCKX4 and NCKX5. Five mutant proteins had no observable NCKX activity, whereas one mutation resulted in a 78% reduction in transport activity. Total protein expression and trafficking to the plasma membrane (the latter with one exception) were not affected in the HEK293 cell expression system. We also analyzed two mutations in a Drosophila NCKX gene that have been reported to result in an increased susceptibility for seizures, and found that both resulted in mutant proteins with significantly reduced but observable NCKX activity. The data presented here support the genetic analyses that mutations in SLC24A4 and SLC24A5 are responsible for the phenotypic defects observed in human patients. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  15. Angular-dependent magnetoresistance study in Ca0.73La0.27FeAs2: a 'parent' compound of 112-type iron pnictide superconductors.

    Science.gov (United States)

    Xing, Xiangzhuo; Xu, Chunqiang; Li, Zhanfeng; Feng, Jiajia; Zhou, Nan; Zhang, Yufeng; Sun, Yue; Zhou, Wei; Xu, Xiaofeng; Shi, Zhixiang

    2017-12-07

    We report a study of angular-dependent magnetoresistance (AMR) with the magnetic field rotated in the plane perpendicular to the current on a Ca 0.73 La 0.27 FeAs 2 single crystal, which is regarded as a 'parent' compound of 112-type iron pnictide superconductors. A pronounced AMR with twofold symmetry is observed, signifying the highly anisotropic Fermi surface. By further analyzing the AMR data, we find that the Fermi surface above the structural/antiferromagnetic (AFM) transition (T s /T N ) is quasi-two-dimensional (quasi-2D), as revealed by the 2D scaling behavior of the AMR, Δρ/ρ(0) (H, θ)  =  Δρ/ρ(0) (µ 0 Hcosθ), θ being the magnetic field angle with respect to the c axis. While such 2D scaling becomes invalid at temperatures below T s /T N , the three-dimensional (3D) scaling approach by inclusion of the anisotropy of the Fermi surface is efficient, indicating that the appearance of the 3D Fermi surface contributes to anisotropic electronic transport. Compared with other experimental observations, we suspect that the additional 3D hole pocket (generated by the Ca d orbital and As1 p z orbital) around the Γ point in CaFeAs 2 will disappear in the heavily electron doped regime, and moreover, the Fermi surface should be reconstructed across the structural/AFM transition. Besides, a quasi-linear in-plane magnetoresistance with H//ab is observed at low temperatures and its possible origins are also discussed. Our results provide more information to further understand the electronic structure of 112-type IBSs.

  16. Impedance spectroscopy studies on lead free (Ba0.85Ca0.15(Ti0.9Zr0.1O3 ceramics

    Directory of Open Access Journals (Sweden)

    Ahcène Chaouchi

    2012-12-01

    Full Text Available The AC complex impedance spectroscopy technique has been used to obtain the electrical parameters of polycrystalline sample of (Ba0.85Ca0.15(Ti0.9Zr0.1O3 in a wide frequency range at different temperatures. This sample was prepared by a high temperature solid-state reaction technique and single phase formation was confirmed by X-ray diffraction technique. This study was carried out by the means of simultaneous analysis of impedance, modulus, and electrical conductivity. The Cole-Cole (Nyquist plots suggest that the grains and grain boundaries are responsible in the conduction mechanism of the material at high temperature. The ColeCole (Nyquist plot studies revealed the presence of grain and grain boundary effect at 485 °C. On the other hand, it showed only the presence of grain boundary component of the resistivity at 535 °C. Complex impedance analysis indicated the presence of non-Debye type dielectric relaxation. The bulk resistance of the material decreases with rise in temperature similar to a semiconductor, and the Cole-Cole (Nyquist plot showed the negative temperature coefficient of resistance (NTCR character of (Ba0.85Ca0.15(Ti0.9Zr0.1O3. The value of activation energy is found to be 0.7433 eV, which suggests that the conduction may be the result of defect and charge carriers present in the materials.

  17. Fabrication and study of stability of Ca2AlWO5,5 ceramic in crude petroleum for applications in petroleum industry

    International Nuclear Information System (INIS)

    Yadava, Y.P.; Silva, N.D.G.; Sousa, A.G. de; Sanguinetti Ferreira, R.A.

    2010-01-01

    Perovskite-type ceramic oxides or their derivatives are used for applications in high technology because of their enormous range of physic-chemical properties with little change in structural characteristics. In this paper we report manufacture ceramic components of a new ceramic Ca 2 AlWO 5,5 by thermo-mechanical process. Stoichiometric amounts of chemical constituents with high degree of purity, were homogenized using a ball mill and high purity alumina balls, compacted by uniaxial pressing and annealed at 1200 deg C for 48 hours. The structural characterization studied by x-ray diffraction that this material has a typical complex ordered cubic perovskite structure. For the study the stability of these ceramics in crude petroleum circular discs of 20 mm diameter and 2 mm thickness were produced and sintering. These discs were submerged in crude petroleum for 15, 30 and 45 days and were examined at each stage by X-ray diffraction, optical microscopy and hardness testing and these results show that Ca 2 AlWO 5,5 are stable in crude petroleum environment. (author)

  18. Low energy resonance in the neutron rich nucleus of 48Ca. New detectors for the study of unstable nuclei: MUST and CATS

    International Nuclear Information System (INIS)

    Ottini, St.

    1998-01-01

    Two new detectors have been developed to study reactions resulting from exotic beams. The first one, MUST, a set of Si strip detectors is devoted to light recoil particles detection between 500 eV and 120 MeV. The 40 Ar elastic and inelastic scattering analysis at 77 MeV per nucleon showed a non ambiguous identification of the particles in the detector, thanks the time and energy resolutions. The second one, CATs, is a set of beam detectors. These low pressure wire chambers allow each particle measurement of the exotic beams with an accuracy of 0,4 mm. A special interest is given to the halo nuclei low excitation energy spectra. A dipolar low energy resonance should be observed. The inelastic scattering at 60 MeV per nucleon on two targets ( 40 Ca and 48 Ca) has been studied with SPEG at Ganil (France), to search a low energy resonance. It is not possible to conclude on this low energy resonance existence. (A.L.B.)

  19. Dynamic phase transitions in La 2/3Ca 1/3MnO3 manganites: A Monte Carlo simulation study

    Science.gov (United States)

    Alzate-Cardona, J. D.; Barco-Ríos, H.; Restrepo-Parra, E.

    2018-03-01

    This work presents a study of dynamic phase transitions in samples of perovskite type manganites of La 2/3Ca 1/3MnO3, when they were submitted to the influence of an external magnetic field that includes both a time dependent and a time independent magnetic fields. This study was carried out based on Monte Carlo simulations and using the Metropolis algorithm and the mixed spin Ising model. Exchange parameters are proposed to simulate this material. These exchange parameters were obtained in order to reproduce the critical temperature for La 2/3Ca 1/3MnO3. Results showed that it exists a competition between different factors that generate order or disorder in the magnetic behavior of that material. It was observed that, as the time independent field increases, the critical temperature increases. Moreover, simulations showed that as the amplitude or the period of the time dependent magnetic field increases, the critical temperature decreases. This behavior allows to assert that an time dependent magnetic field induced disorder while a time independent field induces order.

  20. Isolation of CA1 nuclear enriched fractions from hippocampal slices to study activity-dependent nuclear import of synapto-nuclear messenger proteins.

    Science.gov (United States)

    Yuanxiang, Pingan; Bera, Sujoy; Karpova, Anna; Kreutz, Michael R; Mikhaylova, Marina

    2014-08-10

    Studying activity dependent protein expression, subcellular translocation, or phosphorylation is essential to understand the underlying cellular mechanisms of synaptic plasticity. Long-term potentiation (LTP) and long-term depression (LTD) induced in acute hippocampal slices are widely accepted as cellular models of learning and memory. There are numerous studies that use live cell imaging or immunohistochemistry approaches to visualize activity dependent protein dynamics. However these methods rely on the suitability of antibodies for immunocytochemistry or overexpression of fluorescence-tagged proteins in single neurons. Immunoblotting of proteins is an alternative method providing independent confirmation of the findings. The first limiting factor in preparation of subcellular fractions from individual tetanized hippocampal slices is the low amount of material. Second, the handling procedure is crucial because even very short and minor manipulations of living slices might induce activation of certain signaling cascades. Here we describe an optimized workflow in order to obtain sufficient quantity of nuclear enriched fraction of sufficient purity from the CA1 region of acute hippocampal slices from rat brain. As a representative example we show that the ERK1/2 phosphorylated form of the synapto-nuclear protein messenger Jacob actively translocates to the nucleus upon induction of LTP and can be detected in a nuclear enriched fraction from CA1 neurons.

  1. Ca2+/cation antiporters (CaCA: Identification, characterization and expression profiling in bread wheat (Triticum aestivum L.

    Directory of Open Access Journals (Sweden)

    Mehak Taneja

    2016-11-01

    Full Text Available The Ca2+/cation antiporters (CaCA superfamily proteins play vital function in Ca2+ ion homeostasis, which is an important event during development and defense response. Molecular characterization of these proteins has been performed in certain plants, but they are still not characterized in Triticum aestivum (bread wheat. Herein, we identified thirty four TaCaCA superfamily proteins, which were classified into TaCAX, TaCCX, TaNCL and TaMHX protein families based on their structural organization and evolutionary relation with earlier reported proteins. Since the T. aestivum comprises an allohexaploid genome, TaCaCA genes were derived from each A, B and D subgenome and homeologous chromosome (HC, except chromosome-group 1. Majority of genes were derived from more than one HCs in each family that were considered as homeologous genes (HGs due to their high similarity with each other. These HGs showed comparable gene and protein structures in terms of exon/intron organization and domain architecture. Majority of TaCaCA proteins comprised two Na_Ca_ex domains. However, TaNCLs consisted of an additional EF-hand domain with calcium binding motifs. Each TaCaCA protein family consisted of about ten transmembrane and two α-repeat regions with specifically conserved signature motifs except TaNCL, which had single α-repeat. Variable expression of most of the TaCaCA genes during various developmental stages suggested their specified role in development. However, constitutively high expression of a few genes like TaCAX1-A and TaNCL1-B indicated their role throughout the plant growth and development. The modulated expression of certain genes during biotic (fungal infections and abiotic stresses (heat, drought, salt suggested their role in stress response. Majority of TaCCX and TaNCL family genes were found highly affected during various abiotic stresses. However the role of individual gene needs to be established. The present study unfolded the opportunity

  2. Ca2+/Cation Antiporters (CaCA): Identification, Characterization and Expression Profiling in Bread Wheat (Triticum aestivum L.).

    Science.gov (United States)

    Taneja, Mehak; Tyagi, Shivi; Sharma, Shailesh; Upadhyay, Santosh Kumar

    2016-01-01

    The Ca 2+ /cation antiporters (CaCA) superfamily proteins play vital function in Ca 2+ ion homeostasis, which is an important event during development and defense response. Molecular characterization of these proteins has been performed in certain plants, but they are still not characterized in Triticum aestivum (bread wheat). Herein, we identified 34 TaCaCA superfamily proteins, which were classified into TaCAX, TaCCX, TaNCL, and TaMHX protein families based on their structural organization and evolutionary relation with earlier reported proteins. Since the T. aestivum comprises an allohexaploid genome, TaCaCA genes were derived from each A, B, and D subgenome and homeologous chromosome (HC), except chromosome-group 1. Majority of genes were derived from more than one HCs in each family that were considered as homeologous genes (HGs) due to their high similarity with each other. These HGs showed comparable gene and protein structures in terms of exon/intron organization and domain architecture. Majority of TaCaCA proteins comprised two Na_Ca_ex domains. However, TaNCLs consisted of an additional EF-hand domain with calcium binding motifs. Each TaCaCA protein family consisted of about 10 transmembrane and two α-repeat regions with specifically conserved signature motifs except TaNCL, which had single α-repeat. Variable expression of most of the TaCaCA genes during various developmental stages suggested their specified role in development. However, constitutively high expression of a few genes like TaCAX1-A and TaNCL1-B indicated their role throughout the plant growth and development. The modulated expression of certain genes during biotic (fungal infections) and abiotic stresses (heat, drought, salt) suggested their role in stress response. Majority of TaCCX and TaNCL family genes were found highly affected during various abiotic stresses. However, the role of individual gene needs to be established. The present study unfolded the opportunity for detail

  3. Isospin effects in {sup 40,48}Ca+{sup 40,48}Ca collisions

    Energy Technology Data Exchange (ETDEWEB)

    Henzl, V., E-mail: henzl@mit.ed [MSU-NSCL, 1 Cyclotron, East Lansing MI, 48824 (United States); Henzlova, D.; Kilburn, M. [MSU-NSCL, 1 Cyclotron, East Lansing MI, 48824 (United States); Verde, G. [INFN, Sezione di Catania. 64 Via S. Sofia, I-95123, Catania (Italy); Brown, D. [MSU-NSCL, 1 Cyclotron, East Lansing MI, 48824 (United States); Chbihi, A. [GANIL, CEA et IN2P3-CNRS, B.P. 5027, F-14076 Caen Cedex (France); Coupland, D. [MSU-NSCL, 1 Cyclotron, East Lansing MI, 48824 (United States); Elson, J. [Departments of Chemistry and Physics, Washington University, St. Louis, MO 63130 (United States); Famiano, M. [Western Michigan University, 2229 Everett Tower, Kalamazoo, MI 49008-5252 (United States); Herlitzius, C. [MSU-NSCL, 1 Cyclotron, East Lansing MI, 48824 (United States); Hudan, S. [Indiana Univ. Cyclotron Facility, 2401 Milo B. Sampson Lane, Bloomington, IN 47405-4001 (United States); Lee, J.; Lukyanov, S.; Lynch, W.; Rogers, A.; Sanetullaev, A. [MSU-NSCL, 1 Cyclotron, East Lansing MI, 48824 (United States); Sobotka, L. [Departments of Chemistry and Physics, Washington University, St. Louis, MO 63130 (United States); Souza, R.T. de [Indiana Univ. Cyclotron Facility, 2401 Milo B. Sampson Lane, Bloomington, IN 47405-4001 (United States); Sun, Z.Y.; Tsang, B. [MSU-NSCL, 1 Cyclotron, East Lansing MI, 48824 (United States)

    2010-03-01

    The isospin dependence of two proton correlations is studied in {sup 40}Ca+{sup 40}Ca and {sup 48}Ca+{sup 48}Ca collisions at E/A=80MeV. Measurements were performed with the HiRA detector array complemented by the 4pi Ball at NSCL. We observe a strong isospin dependence of the pp-correlation functions; however the emitting source radius extracted using the imaging technique yields no sensitivity to the isospin of the reaction system. We interpret this result as a consequence of smaller fraction of fast proton emission in the neutron rich {sup 48}Ca system.

  4. Isospin effects in 40,48Ca+40,48Ca collisions

    International Nuclear Information System (INIS)

    Henzl, V.; Henzlova, D.; Kilburn, M.; Verde, G.; Brown, D.; Chbihi, A.; Coupland, D.; Elson, J.; Famiano, M.; Herlitzius, C.; Hudan, S.; Lee, J.; Lukyanov, S.; Lynch, W.; Rogers, A.; Sanetullaev, A.; Sobotka, L.; Souza, R.T. de; Sun, Z.Y.; Tsang, B.

    2010-01-01

    The isospin dependence of two proton correlations is studied in 40 Ca+ 40 Ca and 48 Ca+ 48 Ca collisions at E/A=80MeV. Measurements were performed with the HiRA detector array complemented by the 4π Ball at NSCL. We observe a strong isospin dependence of the pp-correlation functions; however the emitting source radius extracted using the imaging technique yields no sensitivity to the isospin of the reaction system. We interpret this result as a consequence of smaller fraction of fast proton emission in the neutron rich 48 Ca system.

  5. Sporadic Ca and Ca+ layers at mid-latitudes: Simultaneous observations and implications for their formation

    Directory of Open Access Journals (Sweden)

    M. Gerding

    2001-01-01

    Full Text Available We report on the observations of 188 sporadic layers of either Ca atoms and/or Ca ions that we have observed during 112 nights of lidar soundings of Ca, and 58 nights of Ca+ soundings, at Kühlungsborn, Germany (54° N, 12° E. The Ca+ soundings have been performed simultaneously and in a common volume with the Ca soundings by two separate lidars. Correlations between sporadic neutral and ionized metal layers are demonstrated through four case studies. A systematic study of the variations of occurrence of sporadic Ca and Ca+ layers reveals that neutral and ionized Ca layers are not as closely correlated as expected earlier: (a The altitude distribution shows the simultaneous occurrence of both sporadic Ca and Ca+ layers to be most likely only in the narrow altitude range between 90 and 95 km. Above that region, in the lower thermosphere, the sporadic ion layers are much more frequent than atom layers. Below 90 km only very few sporadic layers have been observed; (b The seasonal variation of sporadic Ca layers exhibits a minimum of occurrence in summer, while sporadic Ca+ layers do not show a significant seasonal variation (only the dense Ca+ layers appear to have a maximum in summer. At mid-latitudes sporadic Ca layers are more frequent than sporadic layers of other atmospheric metals like Na or K. For the explanation of our observations new formation mechanisms are discussed.Key words. Ionosphere (ion chemistry and composition; ionosphere-atmosphere interactions; mid-latitude ionosphere

  6. On the discovery of fast molecular gas in the UFO/BAL quasar APM 08279+5255 at z = 3.912

    Science.gov (United States)

    Feruglio, C.; Ferrara, A.; Bischetti, M.; Downes, D.; Neri, R.; Ceccarelli, C.; Cicone, C.; Fiore, F.; Gallerani, S.; Maiolino, R.; Menci, N.; Piconcelli, E.; Vietri, G.; Vignali, C.; Zappacosta, L.

    2017-12-01

    We have performed a high sensitivity observation of the UFO/BAL quasar APM 08279+5255 at z = 3.912 with NOEMA at 3.2 mm, aimed at detecting fast moving molecular gas. We report the detection of blueshifted CO(4-3) with maximum velocity (v95%) of -1340 km s-1, with respect to the systemic peak emission, and a luminosity of L' = 9.9 × 109μ-1 K km s-1 pc-2, where μ is the lensing magnification factor. We discuss various scenarios for the nature of this emission and conclude that this is the first detection of fast molecular gas at redshift > 3. We derived a mass flow rate of molecular gas in the range Ṁ = 3-7.4 × 103M⊙/yr and momentum boost ṖOF/ṖAGN 2-6, which is therefore consistent with a momentum conserving flow. For the largest ṖOF the scaling is also consistent with an energy conserving flow with an efficiency of 10-20%. The present data can hardly discriminate between the two expansion modes. The mass loading factor of the molecular outflow η = ṀOF/SFR is ≫ 1. We also detected a molecular emission line at a frequency of 94.83 GHz corresponding to a rest-frame frequency of 465.8 GHz; we tentatively identified this frequency with the cation molecule N2H+(5-4), which would be the first detection of this species at high redshift. We discuss the alternative possibility that this emission is due to a CO emission line from the, so far undetected, lens galaxy. Further observations of additional transitions of the same species with NOEMA can discriminate between the two scenarios. This work is based on observations carried out under project numbers S15CW and E15AF with the IRAM NOEMA Interferometer. IRAM is supported by INSU/CNRS (France), MPG (Germany), and IGN (Spain). The reduced spectrum (FITS file) is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/608/A30

  7. Study on energy transfer and energy migration of Ca2Gd8(SiO4)6O2:Dy3+ phosphor films.

    Science.gov (United States)

    Wang, X Q; Han, X M; Zhen, C M

    2011-11-01

    Being a kind of rare-earth-metal silicate with oxidapatite structure, Ca2R8(SiO4)6O2 (R = Y, Gd, La) is a promising material doped with rare earth, and widely used as phosphors. In this thesis, Ca2Gd8(SiO4)6O2:Dy3+ films were prepared by the sol-gel method. X-ray diffraction (XRD), atomic force microscopy (AFM), photoluminescence (PL) spectra, and lifetimes were used to characterize the resulting films. AFM study indicated that the phosphor films consisted of 120 nm homogeneous particles. By combining the model of Burshtein for donor-donor migration and the V-F-B model for donor-acceptor energy transfer, the experimental luminescence decay curve of 6P(J) state of Gd3+ was re-simulated. It is found that concentration quenching of Gd3+ can be due to the result of the joint action of donor-donor (Gd3+-Gd3+) energy migration and donor-acceptor (Gd3+-Dy3+) energy transfer.

  8. Land-Sparing Opportunities for Solar Energy Development in Agricultural Landscapes: A Case Study of the Great Central Valley, CA, United States.

    Science.gov (United States)

    Hoffacker, Madison K; Allen, Michael F; Hernandez, Rebecca R

    2017-12-19

    Land-cover change from energy development, including solar energy, presents trade-offs for land used for the production of food and the conservation of ecosystems. Solar energy plays a critical role in contributing to the alternative energy mix to mitigate climate change and meet policy milestones; however, the extent that solar energy development on nonconventional surfaces can mitigate land scarcity is understudied. Here, we evaluate the land sparing potential of solar energy development across four nonconventional land-cover types: the built environment, salt-affected land, contaminated land, and water reservoirs (as floatovoltaics), within the Great Central Valley (CV, CA), a globally significant agricultural region where land for food production, urban development, and conservation collide. Furthermore, we calculate the technical potential (TWh year -1 ) of these land sparing sites and test the degree to which projected electricity needs for the state of California can be met therein. In total, the CV encompasses 15% of CA, 8415 km 2 of which was identified as potentially land-sparing for solar energy development. These areas comprise a capacity-based energy potential of at least 17 348 TWh year -1 for photovoltaic (PV) and 2213 TWh year -1 for concentrating solar power (CSP). Accounting for technology efficiencies, this exceeds California's 2025 projected electricity demands up to 13 and 2 times for PV and CSP, respectively. Our study underscores the potential of strategic renewable energy siting to mitigate environmental trade-offs typically coupled with energy sprawl in agricultural landscapes.

  9. Evaluation of Transvaginal Ultrasound plus CA-125 Measurement and Prophylactic Salpingo-Oophorectomy in Women at Different Risk Levels of Ovarian Cancer: The Modena Study Group Cohort Study.

    Science.gov (United States)

    Cortesi, Laura; De Matteis, Elisabetta; Toss, Angela; Marchi, Isabella; Medici, Veronica; Contu, Giannina; Xholli, Anjeza; Grandi, Giovanni; Cagnacci, Angelo; Federico, Massimo

    2017-01-01

    To evaluate the effectiveness of transvaginal ultrasound (TVU) and serum CA-125 measurement in women at different risk of developing ovarian cancer/fallopian tube cancer (OC/FTC) and the incidence of primary peritoneal cancer (PPC) after risk-reducing salpingo-oophorectomy (RRSO). Between 2002 and 2014, 661 women at different risk of OC/FTC/PPC due to a family history or BRCA1/2 gene mutation were offered TVU and CA-125 measurement or RRSO as prevention strategies. The detection rate of OC/FTC/PPC was evaluated, and the sensitivity and specificity for CA-125 measurement and TVU were calculated. Survival and event analysis was performed for diagnosed patients. After a median follow-up of 112 months, 12 OC/FTC/PPC cases were detected (2.6/1,000 persons/year). The screening sensitivity was 70%, with 73% for BRCA carriers. Six (50%) of 12 cancers were stage I or II. Among 41 women who underwent RRSO, 2 BRCA1 carriers developed a PPC (4.9%). At 61-month follow-up, overall and event-free survival were 75 and 64%, respectively. The cancer detection rate in women with BRCA mutation or a strong family history supports the effectiveness of our surveillance program for early diagnosis. Screening for women at lower risk of OC/FTC is not recommended. A residual risk of PPC after RRSO remains for BRCA1 carriers. © 2017 S. Karger AG, Basel.

  10. Control of ciliary motility by Ca sup 2+ : Integration of Ca sup 2+ -dependent functions and targets for Ca sup 2+ action

    Energy Technology Data Exchange (ETDEWEB)

    Evans, T.C.

    1988-01-01

    To identify functions that regulate Ca{sup 2+}-induced ciliary reversal in Paramecium, mutants defective in terminating depolarization-induced backward swimming were selected. Six independent recessive mutations (k-shy) comprising two complementation groups, k-shyA and k-shyB, were identified. All mutants exhibited prolonged backward swimming in depolarizing solutions. Voltage clamp studies revealed that mutant Ca{sup 2+} current amplitudes were reduced, but could be restored to wild type levels by EGTA injection. The recovery of the mutant Ca{sup 2+} current from Ca{sup 2+}-dependent inactivation, and the decay of the Ca{sup 2+}-dependent K{sup +} and Ca{sup 2+}-dependent Na{sup +} currents after depolarization were slow in k-shy compared to wild type. To identify protein targets of Ca{sup 2+} action, ciliary proteins that interact with calmodulin (CaM) were characterized. With a {sup 125}I-CaM blot assay, several CaM-binding proteins were identified including axonemal, soluble, and membrane-bound polypeptides. Competitive displacement studies with unlabeled Paramecium CaM, bovine CaM, and troponinC suggested that both protein types bind CaM with high affinity and specificity. To examine the presence of CaM-binding sites in intact axonemes, a filtration binding assay was developed.

  11. Neutron diffraction studies on La2-xDyxCa2xBa2Cu4+2xOz superconductors

    International Nuclear Information System (INIS)

    Rayaprol, S.; Parmar, Rohini; Kuberkar, D.G.; Chakraborty, Keka R.; Krishna, P.S.R.; Ramanadham, M.

    2004-01-01

    Structural studies on Dy-substituted La-2125 type superconductors have been carried out by neutron diffraction experiments at room temperature using a monochromatic neutron beam of wavelength (λ) = 1.249 A. A series of samples with La 2-x Dy x Ca 2x Ba 2 Cu 4+2x O z stoichiometric composition, for x = 0.1-0.5, have been studied for their structural properties. A tetragonal Y-123 unit cell was taken as the starting model for the Rietveld analysis. All the samples fit into the starting model, with no structural transition taking place with increasing dopant concentration. The results of Rietveld analysis and structural properties will be discussed in detail. (author)

  12. CAED Document Repository

    Science.gov (United States)

    Compliance Assurance and Enforcement Division Document Repository (CAEDDOCRESP) provides internal and external access of Inspection Records, Enforcement Actions, and National Environmental Protection Act (NEPA) documents to all CAED staff. The respository will also include supporting documents, images, etc.

  13. Toxicological study of DTPA as a drug, 6; Effects of intravenously injected Ca-DTPA, Ca-EDTA, CBMIDA and orally administered Zn-DTPA to bone metabolism in beagle dogs

    Energy Technology Data Exchange (ETDEWEB)

    Fukuda, Satoshi; Iida, Haruzo (National Inst. of Radiological Sciences, Chiba (Japan)); Hseih Yuyuan; Chen Wehzhi

    1991-06-01

    Effects of four kinds of chelating agents, Ca-DTPA (calcium diethylenetriaminepentaacetic acid), Ca-EDTA (calcium ethylenediaminetetraacetic acid), CBMIDA (catechol-3, 6-bis(methyleiminodiacetic acid)) and Zn-DTPA (zinc DTPA), on bone metabolism were examined in beagle dogs by bone histomorphometry and measurement of serum biochemical constituents related to bone metabolism. Ca-DTPA, Ca-EDTA or CBMIDA (150 {mu}mol/kg) was injected intravenously to dogs for 1 month, respectively. Three doses (30, 150 and 300 {mu}mol/kg) of Zn-DTPA were administered orally to dogs for 1 month, respectively. All dogs received twice tetracycline hydrochloride injections at an interval of 7 days before the beginning of administration of chelating agents and also twice calcein injections at the same time schedule prior to sacrifices for analyzing bone dynamics. Bone samples were obtained from ilium and undecalcified bone sections were made. Bone histomorphometry of cancellous bone area of ilium was performed using an image analyzer. Bone volume and mean trabecular thickness did not change in any of the groups. Osteoid volume in the CBMIDA group increased. Osteoid volume and mean osteoid thickness in the 150 {mu}mol/kg of Zn-DTPA group decreased. Mineral apposition rate and bone formation rate did not change in any groups except the CBMIDA and 150 {mu}mol/kg of Zn-DTPA groups, in which fluorescent bone labeling was absent or obscure, revealing inhibition of bone mineralization. Serum total calcium levels did not change in any of the groups. Serum phosphorus level decreased significantly in the 30 {mu}mol/kg dose of Zn-DTPA group. Parathyroid hormone level increased in the 30 {mu}mol/kg dose of Zn-DTPA, while it decreased in the 150 {mu}mol/kg dose of Zn-DTPA group. The results suggests that the protracted therapy using the above four kinds of chelating agents may incur damages of bone such as decrease of bone volume and inhibition of mineralization. (author).

  14. Ab initio study of the structural, electronic, elastic and thermal properties of RMn{sub 2}Ge{sub 2} (R = Ca, Nd and Y) intermetallic compounds

    Energy Technology Data Exchange (ETDEWEB)

    Miloud Abid, O.; Yakoubi, A. [Laboratoire d’Etudes des Matériaux et Instrumentations Expérimentales, Université Djilali Liabes de Sidi Bel-Abbes, 22000 (Algeria); Tadjer, A. [Modeling and Simulation in Materials Science Laboratory, Physics Department, University of Sidi Bel-Abbes, Sidi Bel-Abbes (Algeria); Khenata, R., E-mail: khenata_rabah@yahoo.fr [Laboratoire de Physique Quantique de la Modélisation Mathématique (LPQ3M), Université de Mascara, 29000 (Algeria); Ahmed, R. [Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, UTM Skudai, 81310 Johor (Malaysia); Murtaza, G. [Materials Modeling Laboratory, Department of Physics, Islamia College University, Peshawar (Pakistan); Bin Omran, S. [Department of Physics and Astronomy, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451 (Saudi Arabia); Azam, Sikander [New Technologies – Research Center, University of West Bohemia, Univerzitni 8, 306 14 Pilsen (Czech Republic)

    2014-12-15

    Highlights: • The calculated structural parameters of RMn{sub 2}Ge{sub 2} (R = Ca, Nd and Y) compounds are found in good agreement with the experimental data. • The structural and band structure calculation reveals that these compounds are ferromagnetic brittle metals. • The elastic and thermodynamic properties for the herein studied compounds are investigated for the first time. - Abstract: Intermetallic RMn{sub 2}Ge{sub 2} ternary compounds have attracted considerable attention from researchers in recent years because they show strong indications for novel magnetic characteristics and they have the potential to reveal the mechanism of superlattices. The study of the paramagnetic, ferromagnetic and antiferromagnetic phases affirms the strong dependence to the distance between atomic species in these compounds. In this study, we investigated the structural, elastic, electronic and thermodynamic properties of the intermetallic RMn{sub 2}Ge{sub 2} (R = Ca, Nd and Y) compounds. To carry out this study, we used the full potential (FP) linearized (L) augmented plane wave plus local orbitals (APW + lo), a scheme of calculations developed within the frame work of density functional theory (DFT). To incorporate the exchange correlation (XC) energy and corresponding potential into the total energy calculations, local density approximation (LDA) parameterized by Perdew and Wang is taken into account. Analysis of the density of states (DOS) profile illustrates the conducting nature of these intermetallic compounds; with a predominantly contribution from the R and Mn-d states. At ambient conditions, calculations for elastic constants (C{sub 11}, C{sub 12}, C{sub 13}, C{sub 44}, C{sub 33} and C{sub 66}) are also performed, which point to their brittle character. In addition, the quasi harmonic Debye model was used to predict the thermal properties, together with relative expansion coefficients and heat capacity.

  15. Effects of Ca on microstructure, mechanical and corrosion properties and biocompatibility of Mg-Zn-Ca alloys.

    Science.gov (United States)

    Yin, Ping; Li, Nian Feng; Lei, Ting; Liu, Lin; Ouyang, Chun

    2013-06-01

    Zn and Ca were selected as alloying elements to develop an Mg-Zn-Ca alloy system for biomedical application due to their good biocompatibility. The effects of Ca on the microstructure, mechanical and corrosion properties as well as the biocompatibility of the as-cast Mg-Zn-Ca alloys were studied. Results indicate that the microstructure of Mg-Zn-Ca alloys typically consists of primary α-Mg matrix and Ca₂Mg₆Zn₃/Mg₂Ca intermetallic phase mainly distributed along grain boundary. The yield strength of Mg-Zn-Ca alloy increased slightly with the increase of Ca content, whilst its tensile strength increased at first and then decreased. Corrosion tests in the simulated body fluid revealed that the addition of Ca is detrimental to corrosion resistance due to the micro-galvanic corrosion acceleration. In vitro hemolysis and cytotoxicity assessment disclose that Mg-5Zn-1.0Ca alloy has suitable biocompatibility.

  16. Kinetic and thermodynamic studies of the Co(II) and Ni(II) ions removal from aqueous solutions by Ca-Mg phosphates.

    Science.gov (United States)

    Ivanets, A I; Srivastava, V; Kitikova, N V; Shashkova, I L; Sillanpää, M

    2017-03-01

    The aim of this work was to study the sorption kinetics and thermodynamics of Co(II) and Ni(II) from aqueous solutions by sorbents on the basis of hydrogen (PD-1) and tertiary (PD-2) Ca-Mg phosphates depending on the solution temperature and sorbents chemical composition. Kinetic studies of adsorption of Co(II) and Ni(II) ions onto samples of phosphate sorbents were performed in batch experiment at the temperatures 288, 303, 318 and 333 K. The sorbent dose was fixed at 10 g L -1 , initial pH value 2.6, and contact time varied from 5 to 600 min. The kinetics of Co(II) and Ni(II) adsorption were analyzed by using pseudo-first order, pseudo-second order and intraparticle diffusion models. Thermodynamic parameters (ΔG°, ΔH° and ΔS°) for the sorption of Co(II) and Ni(II) were determined using the Gibbs-Helmholtz equation. The calculated kinetic parameters and corresponding correlation coefficients revealed that Co(II) and Ni(II) uptake process followed the pseudo-second order rate expression. Thermodynamic studies confirmed the spontaneous and endothermic nature of removal process which indicate that sorption of Co(II) and Ni(II) ions onto both phosphate sorbents is favoured at higher temperatures and has the chemisorptive mechanism. The data thus obtained would be useful for practical application of the low cost and highly effective Ca-Mg phosphate sorbents. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Crystal structure and X-ray photoemission spectroscopic study of A{sub 2}LaMO{sub 6} [A=Ba, Ca; M=Nb, Ta

    Energy Technology Data Exchange (ETDEWEB)

    Dutta, Alo, E-mail: alo_dutta@yahoo.com [Department of Condensed Matter Physics and Material Sciences, S. N. Bose National Centre for Basic Sciences, Block-JD, Sector-III, Salt Lake, Kolkata 700098 (India); Saha, Sujoy [Department of Physics, Bose Institute, 93/1 Acharya Prafulla Chandra Road, Kolkata 700009 (India); Kumari, Premlata [Department of Chemistry, Government P.G. College, Lansdowne, Pauri-Garhwal 246139 (India); Sinha, T.P. [Department of Physics, Bose Institute, 93/1 Acharya Prafulla Chandra Road, Kolkata 700009 (India); Shannigrahi, Santiranjan [Institute of Materials Research and Engineering, Agency for Science Technology and Research, 3 Research Link, Singapore 117602 (Singapore)

    2015-09-15

    The X-ray photoemission spectroscopic (XPS) study of the double perovskite oxides A{sub 2}LaMO{sub 6} [A=Ba, Ca; M=Nb, Ta] synthesized by the solid-state reaction technique has been carried out to investigate the nature of the chemical state of the constituent ions and the bonding between them. The Rietveld refinement of the X-ray diffraction patterns suggests the monoclinic crystal structure of all the materials at room temperature. The negative and positive chemical shifts of the core level XPS spectrum of O-1s and Nb-3d{sub 3/2}/Ta-4f{sub 5/2} respectively suggest the covalent bonding between Nb/Ta cations and O ion. The change of the bonding strength between the anion and the cations from one material to another has been analyzed. The vibrational property of the materials is investigated using the room temperature Raman spectra. A large covalency of Ta-based compound than Nb compound is confirmed from the relative shifting of the Raman modes of the materials. - Graphical abstract: Crystal structure of two perovskite oxides CLN and CLT is investigated. XPS study confirms the two different co-ordination environments of Ca and covalent bonding between B-site cations and O-ion. - Highlights: • Ordered perovskite structure obtained by Rietveld refinement of XRD patterns. • Study of nature of chemical bonding by X-ray photoemission spectroscopy. • Opposite chemical shift of d-states of Nb/Ta with respect to O. • Covalent bonding between d-states of Nb/Ta and O. • Relative Raman shifts of CLN and CLT substantiate the more covalent character of Ta than Nb.

  18. In vitro model to study the effects of matrix stiffening on Ca2+handling and myofilament function in isolated adult rat cardiomyocytes.

    Science.gov (United States)

    van Deel, Elza D; Najafi, Aref; Fontoura, Dulce; Valent, Erik; Goebel, Max; Kardux, Kim; Falcão-Pires, Inês; van der Velden, Jolanda

    2017-07-15

    This paper describes a novel model that allows exploration of matrix-induced cardiomyocyte adaptations independent of the passive effect of matrix rigidity on cardiomyocyte function. Detachment of adult cardiomyocytes from the matrix enables the study of matrix effects on cell shortening, Ca 2+ handling and myofilament function. Cell shortening and Ca 2+ handling are altered in cardiomyocytes cultured for 24 h on a stiff matrix. Matrix stiffness-impaired cardiomyocyte contractility is reversed upon normalization of extracellular stiffness. Matrix stiffness-induced reduction in unloaded shortening is more pronounced in cardiomyocytes isolated from obese ZSF1 rats with heart failure with preserved ejection fraction compared to lean ZSF1 rats. Extracellular matrix (ECM) stiffening is a key element of cardiac disease. Increased rigidity of the ECM passively inhibits cardiac contraction, but if and how matrix stiffening also actively alters cardiomyocyte contractility is incompletely understood. In vitro models designed to study cardiomyocyte-matrix interaction lack the possibility to separate passive inhibition by a stiff matrix from active matrix-induced alterations of cardiomyocyte properties. Here we introduce a novel experimental model that allows exploration of cardiomyocyte functional alterations in response to matrix stiffening. Adult rat cardiomyocytes were cultured for 24 h on matrices of tuneable stiffness representing the healthy and the diseased heart and detached from their matrix before functional measurements. We demonstrate that matrix stiffening, independent of passive inhibition, reduces cell shortening and Ca 2+ handling but does not alter myofilament-generated force. Additionally, detachment of adult cultured cardiomyocytes allowed the transfer of cells from one matrix to another. This revealed that stiffness-induced cardiomyocyte changes are reversed when matrix stiffness is normalized. These matrix stiffness-induced changes in cardiomyocyte

  19. Use the nuclear code MCNP4X in the study of the behavior of nuclear probe in soils with variation of Mg, Ca, Fe

    Energy Technology Data Exchange (ETDEWEB)

    Braga, Mario R.M.S.S.; Oliveira, Arno H.; Lima, Claubia P.B., E-mail: mario@nuclear.ufmg.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Engenharia Nuclear; Silva, Clemente J.G.C. da, E-mail: clementecarneiro@gmail.com [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Engenharia Nuclear; Carneiro, Andre C., E-mail: andreccarneiro@gmail.com [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2013-07-01

    The aim of this work is to evaluate the behavior of the variation the elements: Mg, Ca, Fe in the soils composition on a nuclear probe to measure the density of porous materials nondestructive in testing based on coherent Compton Effect, the effect Rayleigh. To study the effect of composition in soil was used nuclear code MCNP4X where was simulated two sources, a source 14mCi americium-241 and other source 4mCi cesium-137, lead shielding and volume scintillator. To avoid problems with geometries were simulated spheres with 1.00 meters of diameter filled with soil to be evaluated. Data analysis allowed establishing correction parameters for nuclear probe. (author)

  20. Phase diagrams and magnetic properties of CaCu3Fe2Os2O12 quadruple perovskite: Monte Carlo study

    Science.gov (United States)

    Sidi Ahmed, S.; Ngantso, G. Dimitri; Bahmad, L.; Benyoussef, A.; El Kenz, A.

    2018-01-01

    In this paper, a Monte Carlo Simulation (MCS) has been used to study the quadruple perovskite oxide CaCu3Fe2Os2O12. The system has been conceived as a mixture of atoms with the magnetic moments Cu (±1/2), Fe (±5/2, ±3/2, ±1/2) and Os (±3/2, ±1/2). Phase diagrams depending on reduced exchange couplings and reduced crystal fields have been established. A stable ferromagnetic phase at the ground state has been found. Investigation of magnetic properties has been focused on the finite size analysis of magnetization and magnetic susceptibility according to reduced temperatures. Critical temperature has been calculated through simulation and the compound has been found to belong in the three-dimensional Ising model universality class.

  1. Use the nuclear code MCNP4X in the study of the behavior of nuclear probe in soils with variation of Mg, Ca, Fe

    International Nuclear Information System (INIS)

    Braga, Mario R.M.S.S.; Oliveira, Arno H.; Lima, Claubia P.B.

    2013-01-01

    The aim of this work is to evaluate the behavior of the variation the elements: Mg, Ca, Fe in the soils composition on a nuclear probe to measure the density of porous materials nondestructive in testing based on coherent Compton Effect, the effect Rayleigh. To study the effect of composition in soil was used nuclear code MCNP4X where was simulated two sources, a source 14mCi americium-241 and other source 4mCi cesium-137, lead shielding and volume scintillator. To avoid problems with geometries were simulated spheres with 1.00 meters of diameter filled with soil to be evaluated. Data analysis allowed establishing correction parameters for nuclear probe. (author)

  2. Neutron Diffraction Study of the High-Tc Superconductor HgBa2CaCu2O6.3 under High Pressure

    International Nuclear Information System (INIS)

    Aksenov, V.L.; Balagurov, A.M.; Savenko, B.N.; Capponi, J.J.; Glazkov, V.P.; Goncharenko, I.N.; Somenkov, V.A.

    1994-01-01

    The pressure dependence of the crystal structure of a powder sample of HgBa 2 CaCu 2 O 6.3 (T c =123 K) was studied in the pressure range of 0 to 3.6 GPa, using the DN-12 time-of-flight diffractometer at the IBR-2 pulsed reactor and a sapphire anvil cell chamber. At P=0 the results are in a good accordance with the published data. At P=3.0 and 3.6 GPa the best fit of the experimental data was achieved using the structural model with apical oxygen disordered in the (a,b) plane. The compressibility values of the lattice constants and selected bonds were calculated from the structural data. The highest absolute value of compressibility was found for the distance between the O atom layers. 12 refs., 6 figs., 3 tabs

  3. Characterization and study of dielectric and electrical properties of CaBi4Ti4O15 (CBT) added with Bi2O3

    International Nuclear Information System (INIS)

    Freitas, D.B.; Campos Filho, M.C.; Sales, J.C.; Silva, P.M.O.; Sombra, A.S.

    2011-01-01

    The ceramic perovskite CaBi 4 Ti 4 O 15 (CBT) of space group A21am, Aurivillius family with deficiency A 5 B 4 O 15 cation has been prepared by solid state method in a planetary ball mill of high energy. The reagents samples were ground and calcined and then added with Bi 2 O 3 (2% wt.) This work aims to characterize by X-ray diffraction to study the electrical properties and dielectric properties of (CBT). The x-ray diffraction revealed the formation of single orthorhombic phase. As for the dielectric properties (dielectric constant and dielectric loss) were measured at 30 deg C to 450 deg C, through which can be verified the presence of thermally activated processes. This phase has properties very relevant for possible use in capacitive devices, miniaturized filters, dielectric resonators antennas and oscillators. (author)

  4. Meta-analysis of cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data

    DEFF Research Database (Denmark)

    Gyöngyösi, Mariann; Wojakowski, Wojciech; Lemarchand, Patricia

    2015-01-01

    RATIONALE: The meta-Analysis of Cell-based CaRdiac study is the first prospectively declared collaborative multinational database, including individual data of patients with ischemic heart disease treated with cell therapy. OBJECTIVE: We analyzed the safety and efficacy of intracoronary cell...... therapy after acute myocardial infarction (AMI), including individual patient data from 12 randomized trials (ASTAMI, Aalst, BOOST, BONAMI, CADUCEUS, FINCELL, REGENT, REPAIR-AMI, SCAMI, SWISS-AMI, TIME, LATE-TIME; n=1252). METHODS AND RESULTS: The primary end point was freedom from combined major adverse...... cardiac and cerebrovascular events (including all-cause death, AMI recurrance, stroke, and target vessel revascularization). The secondary end point was freedom from hard clinical end points (death, AMI recurrence, or stroke), assessed with random-effects meta-analyses and Cox regressions for interactions...

  5. Ca isotopes in refractory inclusions

    International Nuclear Information System (INIS)

    Niederer, F.R.; Papanastassiou, D.A.

    1984-01-01

    We report measurements of the absolute isotope abundance of Ca in Ca-Al-rich inclusions from the Allende and Leoville meteorites. Improved high precision measurements are reported also for 46 Ca. We find that nonlinear isotope effects in Ca are extremely rare in these inclusions. The absence of nonlinear effects in Ca, except for the effects in FUN inclusions, is in sharp contrast to the endemic effects in Ti. One fine-grained inclusion shows an excess of 46 Ca of (7 +- 1) per mille, which is consistent with addition of only 46 Ca or of an exotic (*) component with 46 Ca* approx. 48 Ca*. FUN inclusion EK-1-4-1 shows a small 46 Ca excess of (3.3 +- 1.0) per mille; this confirms that the exotic Ca components in EK-1-4-1 were even more deficient in 46 Ca relative to 48 Ca than is the case for normal Ca. The Ca in the Ca-Al-rich inclusions shows mass dependent isotope fractionation effects which have a range from -3.8 to +6.7 per mille per mass unit difference. This range is a factor of 20 wider than the range previously established for bulk meteorites and for terrestrial and lunar samples. Ca and Mg isotope fractionation effects in the Ca-Al-rich inclusions are common and attributed to kinetic isotope effects. (author)

  6. Charge ordering in Nd{sub 2/3}Ca{sub 1/3}MnO{sub 3}: ESR and magnetometry study

    Energy Technology Data Exchange (ETDEWEB)

    Polishchuk, D.M.; Tovstolytkin, A.I. [Institute of Magnetism of NASU, 36b Vernadsky Boulevard, Kyiv 03680 (Ukraine); Fertman, E.L.; Desnenko, V.A.; Kravchyna, O. [B. Verkin Institute for Low Temperature Physics and Engineering of NASU, 47 Lenin Ave., Kharkov 61103 (Ukraine); Khalyavin, D.D. [ISIS Facility, STFC, Rutherford Appleton Laboratory, Chilton, Didcot, Oxfordshire OX11 0QX (United Kingdom); Salak, A.N. [Department of Materials and Ceramic Engineering/CICECO, University of Aveiro, Aveiro 3810-193 (Portugal); Anders, A.G. [V. N. Karazin Kharkiv National University, 4 Svobody sq., Kharkiv 61000 (Ukraine); Feher, A. [Institute of Physics, Faculty of Science, P. J. Šafárik University in Košice, Park Angelinum 9, Košice 04154 (Slovakia)

    2016-07-15

    The evolution of magnetic and electric properties of the narrow-band manganite Nd{sub 2/3}Ca{sub 1/3}MnO{sub 3} was studied by the electron-spin resonance (ESR), static magnetic field (dc) and resistivity techniques in the temperature range of 100–380 K. It was found that below the charge ordering temperature, T{sub CO}≈212 K, the compound is a mixture of the charge ordered and charge disordered phases in varying proportions depending on the temperature. The exchange phase process, when the amount of the charge ordered phase increases under cooling, while the amount of the charge disordered phase decreases is the most intense between ∼220 K and 180 K. At low temperatures, T<160 K, the charge ordered to the charge disordered phase ratio is about 4:1, which is in excellent agreement with previous neutron diffraction data. Both a sharp decrease of the magnetic susceptibility and a huge resistivity increase are evident of the weakening of ferromagnetic correlations and suppression of the double exchange interaction across the charge ordering due to the localization of the charge carriers. - Highlights: • The electron spin resonance and magnetometry study of Nd{sub 2/3}Ca{sub 1/3}MnO{sub 3} compound has been done. • Phase segregated state of the compound below the charge ordering temperature was revealed. • Charge ordered and charge disordered phases in varying proportions depending on the temperature are coexistent. • The exchange phase process is the most intense between ~220 K and 180 K. • At low temperatures the charge ordered to the charge disordered phase ratio is about 4:1.

  7. Characterization of the differences in the cyclopiazonic acid binding mode to mammalian and P. Falciparum Ca2+ pumps: a computational study.

    KAUST Repository

    Di Marino, Daniele

    2015-03-01

    Despite the investments in malaria research, an effective vaccine has not yet been developed and the causative parasites are becoming increasingly resistant to most of the available drugs. PfATP6, the sarco/endoplasmic reticulum Ca2+ pump (SERCA) of P. falciparum, has been recently genetically validated as a potential antimalarial target and cyclopiazonic acid (CPA) has been found to be a potent inhibitor of SERCAs in several organisms, including P. falciparum. In position 263, PfATP6 displays a leucine residue, whilst the corresponding position in the mammalian SERCA is occupied by a glutamic acid. The PfATP6 L263E mutation has been studied in relation to the artemisinin inhibitory effect on P. falciparum and recent studies have provided evidence that the parasite with this mutation is more susceptible to CPA. Here, we characterized, for the first time, the interaction of CPA with PfATP6 and its mammalian counterpart to understand similarities and differences in the mode of binding of the inhibitor to the two Ca2+ pumps. We found that, even though CPA does not directly interact with the residue in position 263, the presence of a hydrophobic residue in this position in PfATP6 rather than a negatively charged one, as in the mammalian SERCA, entails a conformational arrangement of the binding pocket which, in turn, determines a relaxation of CPA leading to a different binding mode of the compound. Our findings highlight differences between the plasmodial and human SERCA CPA-binding pockets that may be exploited to design CPA derivatives more selective toward PfATP6.

  8. QUANTUM MECHANICAL STUDY OF THE COMPETITIVE HYDRATION BETWEEN PROTONATED QUINAZOLINE AND LI+, NA+, AND CA2+ IONS

    Science.gov (United States)

    Hydration reactions are fundamental to many biological functions and environmental processes. The energetics of hydration of inorganic and organic chemical species influences their fate and transport behavior in the environment. In this study, gas-phase quantum mechanical calcula...

  9. Falls in hospital settings: a longitudinal study Caídas en el medio hospitalario: un estudio longitudinal Quedas em meio hospitalar: um estudo longitudinal

    Directory of Open Access Journals (Sweden)

    Cidalina Abreu

    2012-06-01

    Full Text Available This study aims to assess the prevalence of falls, understand their consequences, identify causes and analyze intervention strategies to prevent them. This is a descriptive longitudinal study, from 2007 to 2009, in which nurses recorded patients' falls in a medicine ward, using a scale developed for this end. Most falls occurred with partially dependent patients, with a mean age ranging from 64 to 74 years. The bedroom was, in all of these years, the place where most of these falls occurred. Although most falls did not have consequences, they were observed in 36% of the cases. The number of falls increased throughout the years of the study. There was also a difference in the percentage of occurrences in the afternoon and night shifts (39% in 2007, 57% in 2008 and 64% in 2009. The identification of obstacles to referral and how to overcome them are analyzed here.Este estudio intenta evaluar la prevalencia de las caídas, conocer sus consecuencias, identificar causas y estudiar estrategias de intervención para prevenirlas. Es un estudio descriptivo longitudinal, realizado entre 2007 y 2009, donde los enfermeros registraron las caídas de enfermos en un servicio de medicina, de acuerdo con una escala elaborada para este propósito. La mayoría de las caídas ocurrió en enfermos parcialmente dependientes, cuyas edades variaban entre 64 y 74 años. La habitación fue, en todos los años, donde mayoritariamente estas ocurrieron. Aunque la mayoría de las caídas no hayan tenido consecuencias, se registraron en 36% de los casos. Este número aumentó a lo largo de los años del estudio. Se rebeló, igualmente, una diferencia en la proporcionalidad del número de registros para los turnos de la tarde/noche (39%, 2007, 57%, 2008 y 64%, 2009. Se analiza la identificación de las barreras a la referencia y como rebasar estas barreras.Este estudo visou avaliar a prevalência das quedas, conhecer as suas consequências, identificar as causas e estudar

  10. Angular-dependent magnetoresistance study in Ca0.73La0.27FeAs2: a "parent" compound of 112-type iron pnictide superconductors.

    Science.gov (United States)

    Xing, Xiangzhuo; Xu, Chunqiang; Li, Zhanfeng; Feng, Jiajia; Zhou, Nan; Zhang, Yufeng; Sun, Yue; Zhou, Wei; Xu, Xiaofeng; Shi, Zhixiang

    2017-11-21

    We report a study of angular-dependent magnetoresistance (AMR) with the magnetic field rotated in the plane perpendicular to the current on a Ca0.73La0.27FeAs2 single crystal, which is regarded as a "parent" compound of 112-type iron pnictide superconductors. A pronounced AMR with twofold symmetry is observed, signifying the highly anisotropic Fermi surface. By further analyzing the AMR data, we find that the Fermi surface above the structural/antiferromagnetic (AFM) transition (Ts/TN) is quasi-two-dimensional (2D), as revealed by the 2D scaling behavior of the AMR, Δρ/ρ(0) (H, θ)=Δρ/ρ(0) (μ0Hcosθ), θ being the magnetic field angle with respect to the c axis. While such a 2D scaling becomes invalid at temperatures below Ts/TN, the three-dimensional (3D) scaling approach by inclusion of the anisotropy of Fermi surface is efficient, indicating that the appearance of 3D Fermi surface contributed to the anisotropic electronic transport. Compared with other experimental observations, we suspect that the additional 3D hole pocket (generated by the Ca d orbital and As1 pz orbital) around the Γ point in CaFeAs2 will disappear in the heavily electron doped regime, and moreover, the Fermi surface should be reconstructed across the structural/AFM transition. Besides, a quasi-linear in-plane magnetoresistance is observed at low temperatures and its possible origins are also discussed. Our results provide more information to further understand the electronic structure of 112-type IBSs. © 2017 IOP Publishing Ltd.

  11. Lateral entorhinal, perirhinal, and amygdala-entorhinal transition projections to hippocampal CA1 and dentate gyrus in the rat: a current source density study.

    Science.gov (United States)

    Canning, K J; Leung, L S

    1997-01-01

    In urethane-anesthetized rats, cortical regions which provide distal dendritic excitation of the dentate gyrus and CA1 of the dorsal hippocampus were studied using current source density analysis. Electrical stimulation of the lateral perforant path (LPP) in the lateral angular bundle, lateral entorhinal cortex (LEC), and amygdala-entorhinal transition (TR) resulted in a current sink in the outer molecular layer of the dentate gyrus accompanied by proximal sources; this sink-source pattern is distinctly different from the source-sink-source pattern evoked by medial perforant path stimulation. The progressive decrease of the sink latency following stimulation of the TR, LEC, and LPP (11.6, 7.8, and 3.6 ms, respectively, at the dorsal blade of the dentate gyrus) suggests a possible sequence of orthodromic activation of these structures. Stimulation of the LEC or TR (collectively termed cortical stimulation) differed from LPP (fiber) stimulation. A low threshold and small chronaxie were characteristic of fiber rather than cortical stimulation. In addition, cortical stimulation, possibly through excitation of intracortical circuits, evoked larger paired-pulse facilitation of the excitatory postsynaptic currents in dentate gyrus and more symmetric excitation of the dorsal and ventral blades of the dentate gyrus as compared to fiber stimulation. Stimulation of the perirhinal cortex (PRh) evoked a short-latency sink in the outer molecular layer of the dentate gyrus with no paired-pulse facilitation, similar to fiber stimulation. A distal dendritic CA1 sink was observed after LPP but not after PRh stimulation. An ibotenic acid injection that lesioned almost all the cells in the perirhinal cortex confirmed the hypothesis that PRh stimulation activated fibers of passage, perhaps in the rostral ventrolateral angular bundle. We conclude that the PRh does not provide a significant excitatory input to the DG or CA1. We have found distinct dendritic excitation of the dentate

  12. Study on the status of breast and prostate cancers in Gazira State using (CA-15-3 and PSA) technology

    International Nuclear Information System (INIS)

    Abd Elgadir, O.M.

    2007-06-01

    This study was conducted in Algezira State in two environmentally and economically different areas. The people in these areas were divided into two groups in the study: group (A) people who live alongside the Blue Nile bank. Group people who live away how the Blue Nile, I e in midland between the Blue Nile and White Nile which is called (AI-Bajour). The aim of the study was to recognize the normal rate of breast cancer markers(Carbohydrate Antigen 15-3), which is one of the most common cancers, and the prostate cancer (Prostate Cancer Markers), as compared with the global normal rate, in order to early detect and treat these types of cancers. The study was conducted on 336 men and 304 women, who are different in ages, work and social status. The researcher used an experimental, descriptive and analytical method, and the SPSS program for analysis. The study showed that the results of normal rate as compared with previous studies are typical to the breast cancer markers (carbohydrate antigen 15-3, ranging between (0-40) ngm/ml, where as the normal rate of the prostate cancer markers (PSA) ranges between (0-4) ngm/ml, and according to the previous African and American studies. The studies also showed that the results are different according to the group are different according to the group involved. There is an increase in normal rates of group (A) in the PSA markers. From 177 men, 49 had rated of (4-10) ng/ml, 6 had very high rates (10-20)ng/ml and extremely high rates of 2 samples (>20)ng/ml. It was noticed that the abnormal increase rate is directly proportional to the age development. The study showed high results of breast cancer markers (Carbohydrate antigen 15-3), as compared with the global normal rate (0-40)ng/ml, 6 had very high rates (60-100)ng/ml and extremely high rates (>100)ng/ml. Two women of uterus cancer died. Again the abnormal increase in the rates is directly proportional to age development. The study showed that the results of group (B) is

  13. The 01+ et 21+ states of 42Ar and 42Ca in the pairing model studied with the (t,p) reaction

    International Nuclear Information System (INIS)

    Warde, Elias.

    1975-01-01

    The differential cross sections of the 40 Ar(t,p) 42 Ar and 40 Ca(t,p) 42 Ca reactions have been measured at 3.3MeV for the ground state and the first 2 + state in 42 Ar and 42 Ca. The shapes of the angular distributions are in satisfactory agreement with the assumption of a direct transfer. The model of Bayman and Hintz for the even-even calcium isotopes is consistent with the relative intensities for the ground state transitions, suggesting similar configurations of the transferred pair in 42 Ar and 42 Ca. The cross sections for the corresponding 2 + states disagree with the model and therefore indicate a different structure of the 2 + states in 42 Ar and 42 Ca [fr

  14. The PACE Study: A randomised clinical trial of cognitive activity (CA for older adults with mild cognitive impairment (MCI

    Directory of Open Access Journals (Sweden)

    Flicker Leon

    2009-12-01

    Full Text Available Abstract Background Research evidence from observational studies suggests that cognitive activity reduces the risk of cognitive impairment in later life as well as the rate of cognitive decline of people with dementia. The Promoting Healthy Ageing with Cognitive Exercise (PACE study has been designed to determine whether a cognitive activity intervention decreases the rate of cognitive decline amongst older adults with mild cognitive impairment (MCI. Methods/Design The study will recruit 160 community-dwelling men and women aged 65 years of age or over with mild cognitive impairment (MCI. Participants will be randomly allocated to two treatment groups: non-specific education and cognitive activity. The intervention will consist of ten 90-minute sessions delivered twice per week over a period of five weeks. The primary outcome measure of the study is the change from baseline in the total score on the Cambridge Cognitive Score (CAMCOG. Secondary outcomes of interest include changes in memory, attention, executive functions, mood and quality of life. Primary endpoints will be collected 12, 52 and 104 weeks after the baseline assessment. Discussion The proposed project will produce the best available evidence on the merits of increased cognitive activity as a strategy to prevent cognitive decline among older adults with MCI. We anticipate that the results of this study will have implications for the development of evidence-based preventive strategies to reduce the rate of cognitive decline amongst older people at risk of dementia. Trial registration ACTRN12608000556347

  15. Hydrogen peroxide inhibits Ca2+efflux through plasma membrane Ca2+-ATPase in mouse parotid acinar cells.

    Science.gov (United States)

    Kim, Min Jae; Choi, Kyung Jin; Yoon, Mi Na; Oh, Sang Hwan; Kim, Dong Kwan; Kim, Se Hoon; Park, Hyung Seo

    2018-03-01

    Intracellular Ca 2+ mobilization is closely linked with the initiation of salivary secretion in parotid acinar cells. Reactive oxygen species (ROS) are known to be related to a variety of oxidative stress-induced cellular disorders and believed to be involved in salivary impairments. In this study, we investigated the underlying mechanism of hydrogen peroxide (H 2 O 2 ) on cytosolic Ca 2+ accumulation in mouse parotid acinar cells. Intracellular Ca 2+ levels were slowly elevated when 1 mM H 2 O 2 was perfused in the presence of normal extracellular Ca 2+ . In a Ca 2+ -free medium, 1 mM H 2 O 2 still enhanced the intracellular Ca 2+ level. Ca 2+ entry tested using manganese quenching technique was not affected by perfusion of 1 mM H 2 O 2 . On the other hand, 10 mM H 2 O 2 induced more rapid Ca 2+ accumulation and facilitated Ca 2+ entry from extracellular fluid. Ca 2+ refill into intracellular Ca 2+ store and inositol 1,4,5-trisphosphate (1 µM)-induced Ca 2+ release from Ca 2+ store was not affected by 1 mM H 2 O 2 in permeabilized cells. Ca 2+ efflux through plasma membrane Ca 2+ -ATPase (PMCA) was markedly blocked by 1 mM H 2 O 2 in thapsigargin-treated intact acinar cells. Antioxidants, either catalase or dithiothreitol, completely protected H 2 O 2 -induced Ca 2+ accumulation through PMCA inactivation. From the above results, we suggest that excessive production of H 2 O 2 under pathological conditions may lead to cytosolic Ca 2+ accumulation and that the primary mechanism of H 2 O 2 -induced Ca 2+ accumulation is likely to inhibit Ca 2+ efflux through PMCA rather than mobilize Ca 2+ ions from extracellular medium or intracellular stores in mouse parotid acinar cells.

  16. Wave Energy Converter Effects on Wave Fields: Evaluation of SNL-SWAN and Sensitivity Studies in Monterey Bay CA.

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, Jesse D.; Chang, Grace; Magalen, Jason; Jones, Craig

    2014-09-01

    A modified version of an indust ry standard wave modeling tool was evaluated, optimized, and utilized to investigate model sensitivity to input parameters a nd wave energy converter ( WEC ) array deployment scenarios. Wave propagation was investigated d ownstream of the WECs to evaluate overall near - and far - field effects of WEC arrays. The sensitivity study illustrate d that wave direction and WEC device type we r e most sensitive to the variation in the model parameters examined in this study . Generally, the changes in wave height we re the primary alteration caused by the presence of a WEC array. Specifically, W EC device type and subsequently their size directly re sult ed in wave height variations; however, it is important to utilize ongoing laboratory studies and future field tests to determine the most appropriate power matrix values for a particular WEC device and configuration in order to improve modeling results .

  17. Studies on the luminescence properties of cerium co-doping on Ca2MgSi2O7:Eu2+phosphor by solid-state reaction method.

    Science.gov (United States)

    Sahu, Ishwar Prasad; Bisen, D P; Murthy, K V R; Tamrakar, R K

    2017-11-01

    Ca 2 MgSi 2 O 7 :Ce 3+ , Ca 2 MgSi 2 O 7 :Eu 2+ and Ca 2 MgSi 2 O 7 :Eu 2+ ,Ce 3+ phosphors were prepared using the solid-state reaction method. The crystal structures of the sintered phosphors were of melilite type, which has a tetragonal crystallography. The chemical compositions of the sintered phosphors was confirmed by energy dispersive X-ray spectroscopy. The different thermoluminescence kinetic parameters [activation energy (E), frequency factor (s) and order of the kinetics (b)] of these phosphors were evaluated and compared using the peak shape method. Under ultraviolet excitation, the emission spectra of both Ca 2 MgSi 2 O 7 :Eu 2+ and Ca 2 MgSi 2 O 7 :Eu 2+ ,Ce 3+ phosphors were composed of a broad emission band peaking at 530 nm. When the Ca 2 MgSi 2 O 7 :Eu 2+ phosphor is co-doped with Ce 3+ ions, photoluminescence, afterglow and mechanoluminescence intensity was strongly enhanced. Ca 2 MgSi 2 O 7 :Eu 2+ showed some afterglow with a short persist time. On incorporation of Ce 3+ , efficient energy transfer from Ce 3+ to Eu 2+ was found and the emission intensity of Eu 2+ was enhanced. The mechanoluminescence intensities of Ca 2 MgSi 2 O 7 :Ce 3+ , Ca 2 MgSi 2 O 7 :Eu 2+ and Ca 2 MgSi 2 O 7 :Eu 2+ ,Ce 3+ phosphors increased proportionally increased with the increase in impact velocity, which suggests that these phosphors can be used as sensors to detect stress in an object. Copyright © 2017 John Wiley & Sons, Ltd.

  18. The strong prognostic value of KELIM, a model-based parameter from CA 125 kinetics in ovarian cancer: data from CALYPSO trial (a GINECO-GCIG study).

    Science.gov (United States)

    You, Benoit; Colomban, Olivier; Heywood, Mark; Lee, Chee; Davy, Margaret; Reed, Nicholas; Pignata, Sandro; Varsellona, Nenzi; Emons, Günter; Rehman, Khalid; Steffensen, Karina Dahl; Reinthaller, Alexander; Pujade-Lauraine, Eric; Oza, Amit

    2013-08-01

    Unexpected results were recently reported about the poor surrogacy of Gynecologic Cancer Intergroup (GCIG) defined CA-125 response in recurrent ovarian cancer (ROC) patients. Mathematical modeling may help describe CA-125 decline dynamically and discriminate prognostic kinetic parameters. Data from CALYPSO phase III trial comparing 2 carboplatin-based regimens in ROC patients were analyzed. Based on population kinetic approach, serum [CA-125] concentration-time profiles during first 50 treatment days were fit to a semi-mechanistic model with following parameters: "d[CA-125]/dt=(KPROD∗exp (BETA∗t))∗Effect-KELIM∗[CA-125]" with time, t; tumor growth rate, BETA; CA-125 tumor production rate, KPROD; CA-125 elimination rate, KELIM and K-dependent treatment indirect Effect. The predictive values of kinetic parameters were tested regarding progression-free survival (PFS) against other reported prognostic factors. Individual CA-125 kinetic profiles from 895 patients were modeled. Three kinetic parameters categorized by medians had predictive values using univariate analyses: K; KPROD and KELIM (all PCA-125 response (favoring carboplatin-paclitaxel arm), treatment arm, platinum free-interval, measurable lesions and KELIM (HR=0.53; 95% CI 0.45-0.61; PCA-125 kinetics in ROC patients enables understanding of the time-change components during chemotherapy. The contradictory surrogacy of GCIG-defined CA-125 response was confirmed. The modeled CA-125 elimination rate KELIM, potentially assessable in routine, may have promising predictive value regarding PFS. Further validation of this predictive marker is warranted. Copyright © 2013 Elsevier Inc. All rights reserved.

  19. Neutron diffraction studies on Ca1− xBaxZr4P6O24 solid solutions

    Indian Academy of Sciences (India)

    P6O24 compositions from combined Rietveld refinements of powder X-ray and neutron diffraction data. All the studied compositions crystallize in rhombohedral lattice (space group R-3 No. 148). A continuous solid solution is concluded from ...

  20. Wavelength dependence in laser floating zone processing. A case study with Bi-Sr-Ca-Cu-O superconductors

    International Nuclear Information System (INIS)

    Fuente, G.F. de la; Diez, J.C.; Angurel, L.A.; Pena, J.I.; Sotelo, A.; Navarro, R.

    1995-01-01

    Laser floating zone processing methods are particularly suitable for studying crystal growth and the development of texture from the melt in many materials used in electrooptics, for example. A system is described that allows different laser wavelengths to be used, and first results on BSCCO superconducting fibers processed using different lasers are presented. (orig.)

  1. Galen reconsidered. Studying drug properties and the foundations of medicine in the Dutch Republic ca. 1550-1700

    NARCIS (Netherlands)

    Klerk, Saskia|info:eu-repo/dai/nl/317919725

    2015-01-01

    What happened to the work of Roman physician Galen (130-200 AD) in the seventeenth century? Was it rejected as a consequence of the Scientific Revolution? Or did it live on in some way? This dissertation examines these classic medical historical questions by studying the investigation of drug

  2. Study of Prevalence and Characteristics of Staphylococcus aureus and CA-MRSA Nasal Colonization in 2-5 Years Old Children in Isfahan

    Directory of Open Access Journals (Sweden)

    Ramin Dibaj

    2014-10-01

    Full Text Available Background and Aim: We carried out a descriptive study to determine the extent of nasal colonization and characteristics of Staphylococcus aureus and CA-MRSA isolates in 2-5 year old children of day care centers in Isfahan. Materials and Methods: The characteristics of isolates were determined using standard phenotypic profiles including colony morphology, Gram staining, catalase, hyaluronidase, coagulase and Dnase tests as well as mannitol fermentation. The MRSA detection was carried out according to CLSI guidelines with oxacillin agar screen test. Methicillin resistance was further confirmed by detection of a 310 bp fragment of mecA gene of MRSA by PCR. Drug susceptibility testing to antibiotics other than methicillin was conducted by disk diffusion. The Beta-lactamase production and inducible clindamycin resistance were also determined by performing the double-disc diffusion(D-test. Results: Out of 323 children, 115 (35.6% carried S. aureus and 11 (9.5% carried MRSA. All MRSA strains were found to contain mecA gene. The susceptibility of strains to vancomycin, rifampicin and Linezolid were 100%. The susceptibility of strains to gentamicin, clindamycin, erythromycin, co-trimoxazole, amoxiclav, ciprofloxacin, tetracycline and penicillin were 99%, 97%, 94%, 94%, 93%, 88%, 44.4% and 1.8% respectively. Beta-lactamase production was seen in 19 (16.5% of staphylococcal strains. Inducible clindamycin resistance was seen in 4 (3.5% of the isolates. Conclusions: Our data indicates that the spread of CA-MRSA within Iranian population is worthy of consideration and merits further molecular investigation to determine the source and mode of transmission.

  3. The study of structural phase transitions and static properties using transition metal model pseudopotential (TMMP) for Ca and Sr

    Energy Technology Data Exchange (ETDEWEB)

    Rakhecha, Shalu, E-mail: shalurakhecha@yahoo.com; Vyas, P. R.; Gohel, V. B. [Department of Physics, School of Sciences, Gujarat University, Ahmedabad - 380009, Gujarat (India); Bhatt, N. K. [Department of Physics, Sardar Patel University, Vallabh Vidyanagar - 388120, Gujarat (India)

    2016-05-06

    In the present communication, we have computed static and dynamic properties (binding energy-E, bulk modulus-B and second moment- <ω{sup 2}>) as well as first order pressure induced phase transition (FCC-BCC) using local form of pseudopotential for Calcium and Strontium. The form of pseudopotential used for the computation is directly extracted from Generalized Pseudopotential Theory (GPT) which contains three parameters (r{sub c}, r{sub d} and β). We have suggested a simple method using which pseudopotential is determined by single parameter (β). Our computed results for binding energy and bulk modulii are in excellent agreement with experimental findings and are better than other theoretical results. The present study confirms that s-d hybridization is accounted properly in the presently used pseudopotential and can be extended for the study of lattice mechanical properties of these metals.

  4. Positive side effects of Ca antagonists for osteoarthritic joints?results of an in vivo pilot study

    OpenAIRE

    Daniilidis, Kiriakos; Georges, Philipp; Tibesku, Carsten O; Prehm, Peter

    2015-01-01

    Background We have shown previously that some calcium antagonists inhibit hyaluronan export, loss of proteoglycans, and degradation of collagen from osteoarthritic cartilage. Clinically approved calcium antagonists normally are prescribed for cardiac arrhythmia. In the present study, we compared the effect of these drugs on osteoarthritic patients which had received no medication and patients which were also diagnosed for cardiac arrhythmias and were treated with calcium antagonists. The effe...

  5. Biomarker CA125

    DEFF Research Database (Denmark)

    Kargo, Anette Stolberg

    be detected months before symptoms arise and recurrence is visible on imaging. Therefore, biochemical detection of potential relapse by CA125 assessment can cause significant distress. A decision aid (DA) is a tool that provides information and describes advantages and disadvantages of a specific intervention...... patient organisations and cancer societies. First, a focus group of seven former OC patients was performed followed by a quantitative rating of the DA pilot version. The DA was adapted accordingly and then tested in 14 OC patients with recurrence using a structured interview guide (alpha testing). A final...... agreed that the DA prepared them to make a better decision and helped them reflecting on their concerns regarding CA125. Conclusion: The DA was useful in decision making regarding monitoring CA125 during follow up after OC. The majority of participants indicated that the DA was helpful in clarifying...

  6. The Palermo Capuchin Catacombs Project: a multidisciplinary approach to the study of a modern Mummy Collection (ca 1600-1900

    Directory of Open Access Journals (Sweden)

    Luca Sineo

    2008-04-01

    Full Text Available In this paper we present a multidisciplinary project for the study of the present conditions, history, bioanthropological features and conservation status of a large collection of modern human mummies, kept in the Capuchin Catacombs of Palermo (Sicily, Italy. Due to the large amount of spontaneously and anthropogenically mummified human bodies, and to an abundant presence of associated artefacts, this collection provides a unique opportunity to carry out a large multidisciplinary survey useful for a thorough biocultural understanding of these remains, a conservation plan, and testing of new restoration protocols.

  7. Ca-Dependent Folding of Human Calumenin

    Science.gov (United States)

    Mazzorana, Marco; Hussain, Rohanah; Sorensen, Thomas

    2016-01-01

    Human calumenin (hCALU) is a six EF-hand protein belonging to the CREC family. As other members of the family, it is localized in the secretory pathway and regulates the activity of SERCA2a and of the ryanodine receptor in the endoplasmic reticulum (ER). We have studied the effects of Ca2+ binding to the protein and found it to attain a more compact structure upon ion binding. Circular Dichroism (CD) measurements suggest a major rearrangement of the protein secondary structure, which reversibly switches from disordered at low Ca2+ concentrations to predominantly alpha-helical when Ca2+ is added. SAXS experiments confirm the transition from an unfolded to a compact structure, which matches the structural prediction of a trilobal fold. Overall our experiments suggest that calumenin is a Ca2+ sensor, which folds into a compact structure, capable of interacting with its molecular partners, when Ca2+ concentration within the ER reaches the millimolar range. PMID:26991433

  8. Evaluation of Mechanical Properties and Morphological Studies of Rice Husk (Treated/Untreated)-CaCO3 Reinforced Epoxy Hybrid Composites

    Science.gov (United States)

    Verma, Deepak; Joshi, Garvit; Gupta, Ayush

    2016-10-01

    Natural fiber reinforced composites are a very popular area of research because of the easy availability and biodegradability of these fibers. The manufacturing of natural fiber composite is done by reinforcing fibers in the particulate form, fiber form or in woven mat form. Natural fiber composites also utilize industrial wastes as a secondary reinforcements like fly ash, sludge etc. By keeping all these point of views in the present investigation the effect of rice husk flour (chemically treated/untreated) and micro sized calcium carbonate with epoxy resin have been evaluated. The diameter of rice husk flour was maintained at 600 µm through mechanical sieving machine. The husk flour was chemically treated with NaOH (5 % w/v). Mechanical properties like hardness, flexural impact and compression strength were evaluated and found to be superior in modified or chemically treated flour as compared to unmodified or untreated flour reinforced composites. Scanning electron microscopy (SEM) study was also undertaken for the developed composites. SEM study shows the distribution of the rice husk flour and calcium carbonate over the matrix.

  9. Petroleum Weathering Associated with Hydrocarbon Migration and Seepage, a Case Study From the Santa Barbara Channel, CA.

    Science.gov (United States)

    Wardlaw, G. D.; Nelson, R. K.; Reddy, C. M.; Valentine, D. L.

    2005-12-01

    A 2003 report by the National Research Council estimates that 50 to 70 percent of oil that is released into the sea is from natural seeps (National Research Council, 2003), indicating that catastrophic oil spills or the runoff from roads and highways are not the major sources of oil in the marine environment. For example, approximately 37 tons of petroleum is emitted daily from seeps off the coast of Santa Barbara, California (Quigley et al. 1996). The Santa Barbara seeps are some of the most active in the world and have been releasing petroleum for thousands of years. Sheens of oil on the water surface and tar patches on the beaches are ubiquitous along the coastline of Santa Barbara and are continuing reminders of this natural process. Although the geochemistry of these seeps have been studied in the past, it has been hindered by the complexity of the petroleum hydrocarbons and the inability of traditional gas chromatography to separate, identify, and quantify each component of the oil. To expand on these previous efforts, we have begun to use comprehensive two-dimensional gas chromatography (GCxGC). This new technology provides at least an order of magnitude increase in the resolution and detection of petroleum hydrocarbons compared to traditional methods. Preliminary work using GCxGC has focused on examining the chemical composition of unrefined petroleum as it migrates up from depth through natural faults to the seafloor, from the seafloor to the sea surface, and from the sea surface to local beaches. Petroleum collected from a subsurface reservoir (Platform Holly Well 2342-15) is composed of a wide range of resolved petroleum hydrocarbons including n-alkanes, branched alkanes, cycloalkanes, linear alkane benzenes, polycyclic aromatic hydrocarbons, steranes, hopanes, cyclic isoprenoids, and very large branched biomarkers with 38 to 40 carbons. This product is significantly different than oil emerging from the seafloor at the Jackpot seep, which we believe is

  10. Creative Ventures: Mysteries and UFO's.

    Science.gov (United States)

    Stark, Rebecca

    This book published in 1987 provides open-ended activities to extend the imagination and creativity of students and encourage them to examine their feelings and values. Williams' model of cognitive-intellective and affective-feeling domains are addressed. Nearly 60 pages of exercises focus on the historical, the scientific, the mysterious, the…

  11. Phosphorylation and activation of nuclear Ca{sup 2+}/calmodulin-dependent protein kinase phosphatase (CaMKP-N/PPM1E) by Ca{sup 2+}/calmodulin-dependent protein kinase I (CaMKI)

    Energy Technology Data Exchange (ETDEWEB)

    Onouchi, Takashi [Department of Life Sciences, Faculty of Agriculture, Kagawa University, Miki-cho, Kagawa 761-0795 (Japan); Sueyoshi, Noriyuki, E-mail: sueyoshi@ag.kagawa-u.ac.jp [Department of Life Sciences, Faculty of Agriculture, Kagawa University, Miki-cho, Kagawa 761-0795 (Japan); Ishida, Atsuhiko [Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521 (Japan); Kameshita, Isamu [Department of Life Sciences, Faculty of Agriculture, Kagawa University, Miki-cho, Kagawa 761-0795 (Japan)

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer CaMKP-N/PPM1E underwent proteolytic processing and translocated to cytosol. Black-Right-Pointing-Pointer The proteolysis was effectively inhibited by the proteasome inhibitors. Black-Right-Pointing-Pointer Ser-480 of zebrafish CaMKP-N was phosphorylated by cytosolic CaMKI. Black-Right-Pointing-Pointer Phosphorylation-mimic mutants of CaMKP-N showed enhanced activity. Black-Right-Pointing-Pointer These results suggest that CaMKP-N is regulated by CaMKI. -- Abstract: Nuclear Ca{sup 2+}/calmodulin-dependent protein kinase phosphatase (CaMKP-N/PPM1E) is an enzyme that dephosphorylates and downregulates multifunctional Ca{sup 2+}/calmodulin-dependent protein kinases (CaMKs) as well as AMP-dependent protein kinase. In our previous study, we found that zebrafish CaMKP-N (zCaMKP-N) underwent proteolytic processing and translocated to cytosol in a proteasome inhibitor-sensitive manner. In the present study, we found that zCaMKP-N is regulated by phosphorylation at Ser-480. When zCaMKP-N was incubated with the activated CaMKI, time-dependent phosphorylation of the enzyme was observed. This phosphorylation was significantly reduced when Ser-480 was replaced by Ala, suggesting that CaMKI phosphorylates Ser-480 of zCaMKP-N. Phosphorylation-mimic mutants, S480D and S480E, showed higher phosphatase activities than those of wild type and S480A mutant in solution-based phosphatase assay using various substrates. Furthermore, autophosphorylation of CaMKII after ionomycin treatment was more severely attenuated in Neuro2a cells when CaMKII was cotransfected with the phosphorylation-mimic mutant of zCaMKP-N than with the wild-type or non-phosphorylatable zCaMKP-N. These results strongly suggest that phosphorylation of zCaMKP-N at Ser-480 by CaMKI activates CaMKP-N catalytic activity and thereby downregulates multifunctional CaMKs in the cytosol.

  12. Study on the adsorption performance of composite adsorbent of CaCl2 and expanded graphite with ammonia as adsorbate

    International Nuclear Information System (INIS)

    Li, S.L.; Wu, J.Y.; Xia, Z.Z.; Wang, R.Z.

    2009-01-01

    A novel constant volume test unit was built to study the adsorption performance of a new type composite adsorbent. This test unit can measure the adsorption isosteres of the working pairs. The adsorption isosteres are the curves of the adsorption pressure variation with the adsorption temperatures at constant adsorption quantities. Compared to the former test results of isothermals and isobars, the isosteres are better for the calculation of the adsorption heat, desorption heat and the selection the adsorption working pairs. Three experimental results were obtained: the first result was that the expanded graphite powders were superior to the expandable graphite powders to facilitate the transportation of working fluid in the composite adsorbent. The second one was that the composite adsorbent treated by solution is more homogeneous than the simple mixed composite adsorbent and the treated composite adsorbent has a better mass transfer performance. The last one was that the adsorption isosteres was the same one not only in the heating process but also in the cooling process and this performance was not relevant to the homogeneity of the composite adsorbent

  13. Study of chromites YbMIICr2O5,5 (MII - Mg, Ca, Sr, Ba by X-ray diffraction

    Directory of Open Access Journals (Sweden)

    B. Kasenov

    2012-03-01

    Full Text Available Compounds of composition YbMeMnFeO5,5 (Me – Mg, Ca, Sr, Ba are synthesized from Yb2O3, , Cr2O3 and MgCO3, CaCO3, SrCO3, BaCO3 by solid phase method. X-ray powder diffraction showed that the compound YbMgCr2O5,5, YbCaCr2O5,5, YbSrCr2O5,5, YbBaCr2O5,5 crystallizes in the tetragonal crystal system.

  14. Preliminary Magnetostratigraphic Study of the Split Mountain and Lower Imperial Groups, Split Mountain Gorge, Western Salton Trough, CA

    Science.gov (United States)

    Fluette, A. L.; Housen, B. A.; Dorsey, R. J.

    2004-12-01

    We present preliminary results of a magnetostratigraphic study of Miocene-Pliocene sedimentary rocks of the Split Mt. and lower Imperial Groups exposed in Split Mt. Gorge and eastern Fish Creek-Vallecito basin, western Salton Trough. Precise age control for the base of this thick section is needed to improve our understanding of the early history of extension-related subsidence in this region. The geologic setting and stratigraphic framework are known from previous work by Dibblee (1954, 1996), Woodard (1963), Kerr (1982), Winker (1987), Kerr and Kidwell (1991), Winker and Kidwell (1986; 1996), and others. We have analyzed Upper Miocene to lower Pliocene strata exposed in a conformable section in Split Mt. Gorge, including (in order from the base; nomenclature of Winker and Kidwell, 1996): (1) Split Mt. Group: Red Rock Fm alluvial sandstone; Elephant Trees alluvial conglomerate; and lower megabreccia unit; and (2) lower part of Imperial Group, including: Fish Creek Gypsum; proximal to distal turbidites of the Latrania Fm and Wind Caves Mbr of Deguynos Fm; upper megabreccia unit; marine mudstone and rhythmites of the Mud Hills Mbr (Deguynos Fm); and the basal part of the Yuha Mbr (Deguynos Fm). Measured thickness from the base of the Elephant Trees Cgl to the base of the Yuha Mbr is about 1050 m, consistent with previous measurements of Winker (1987). Paleomagnetic samples were collected at approximately 10 m intervals throughout this section. The upper portion of our sampled section overlaps with the lower part of the section sampled for magnetostratigraphic study by Opdyke et al. (1977) and Johnson et al. (1983). They interpreted the base of their section to be about 4.3 Ma, and calculated an average sedimentation rate of approximately 5.5 mm/yr for the lower part of their section. Good-quality preliminary results from 15 paleomagnetic sites distributed throughout our sampled section permit preliminary identification of 6 polarity zones. Based on regional mapping

  15. Electronic structures and magnetism of CaFeAsH and CaFeAsF

    International Nuclear Information System (INIS)

    Wang Guangtao; Shi Xianbiao; Liu Haipeng; Liu Qingbo

    2015-01-01

    We studied the electronic structures, magnetism, and Fermi surface (FS) nesting of CaFeAsH and CaFeAsF by first-principles calculations. In the nonmagnetic (NM) states, we found strong FS nesting, which induces magnetic instability and a spin density wave (SDW). Our calculations indicate that the ground state of CaFeAsH and CaFeAsF is the stripe antiferromagnetic state. The calculated bare susceptibility χ 0 (q) peaked at the M-point and was clearly suppressed and became slightly incommensurate with both electron doping and hole doping for both materials. (author)

  16. Results of measuring internal Ca absorption and Ca kinetics with /sup 47/Ca in patients suffering from chronically recurrent urolithiasis

    Energy Technology Data Exchange (ETDEWEB)

    Hoffmann, L.; Esther, G.; Serfling, D.; Bast, R. (Rostock Univ. (German Democratic Republic). Radiologische Klinik)

    1983-07-01

    47 patients with chronically recurrent calcium lithiasis (with between 3 and over 100 stone episodes) and an average age of 43.2 years have been examined. The Ca absorption lay between 42.7% and 90.0% of the dose, the average was 59.3% with a standard deviation of +- 12.9. This is higher than in persons with healthy kidneys. The Ca absorption is significantly lower in patients with renal insufficiency. Studies on Ca kinetics revealed turnover rates and pool sizes within the normal range.

  17. Results of measuring enteral Ca absorption and Ca kinetics with 47Ca in patients suffering from chronically recurrent urolithiasis

    International Nuclear Information System (INIS)

    Hoffmann, L.; Esther, G.; Serfling, D.; Bast, R.

    1983-01-01

    47 patients with chronically recurrent calcium lithiasis (with between 3 and over 100 stone episodes) and an average age of 43.2 years have been examined. The Ca absorption lay between 42.7% and 90.0% of the dose, the average was 59.3% with a standard deviation of +- 12.9. This is higher than in persons with healthy kidneys. The Ca absorption is significantly lower in patients with renal insufficiency. Studies on Ca kinetics revealed turnover rates and pool sizes within the normal range. (author)

  18. Risk factors associated with incident clinical vertebral and nonvertebral fractures in postmenopausal women: the Canadian Multicentre Osteoporosis Study (CaMos).

    Science.gov (United States)

    Papaioannou, Alexandra; Joseph, Lawrence; Ioannidis, George; Berger, Claudie; Anastassiades, Tassos; Brown, Jacques P; Hanley, David A; Hopman, Wilma; Josse, Robert G; Kirkland, Susan; Murray, Timothy M; Olszynski, Wojciech P; Pickard, Laura; Prior, Jerilynn C; Siminoski, Kerry; Adachi, Jonathan D

    2005-05-01

    Utilizing data from the Canadian Multicentre Osteoporosis Study (CaMos), we examined the association between potential risk factors and incident vertebral and nonvertebral fractures. A total of 5,143 postmenopausal women were enrolled. Information collected during the study included data from the CaMos baseline and annually mailed fracture questionnaires, the Short Form 36 (SF-36), the Health Utilities Index, and physical measurements. Participants were followed for 3 years. Postmenopausal women were classified into four groups according to their incident fracture status since baseline: those without a new fracture; those with a new clinically recognized vertebral fracture; those with an incident nonvertebral fracture at the wrist, hip, humerus, pelvis, or ribs (main nonvertebral fracture group); and those with any new nonvertebral fracture (any-nonvertebral-fracture group). We performed multivariate Cox proportional hazard analysis using all possible risk factors to determine the association between risk factors and the time to the first minimal trauma fracture. Best predictive models were also determined using variables that were included in the full models. The Bayesian information criterion was used for model selection. For all analyses, relative risks and associated 95% confidence intervals were calculated. During the follow-up period, 34, 163, and 280 women developed a vertebral, a main nonvertebral, or any nonvertebral fracture, respectively. The best predictive models indicated that a five point lower quality of life as measured by the SF-36 physical component summary score was associated with relative risks of 1.21 (95% CI, 1.02 to 1.44), 1.17 (95% CI, 1.07 to 1.28), and 1.19 (95% CI, 1.11 to 1.27) for incident vertebral, main nonvertebral, and all nonvertebral fractures, respectively. In addition, for a one standard deviation (SD=0.12) lower femoral neck BMD, the relative risks for incident vertebral, main nonvertebral, and any nonvertebral fractures

  19. Commercial- and whitewashing-grade limestone as a heterogeneous catalyst for synthesis of fatty acid methyl esters from used frying oil (UFO)

    Energy Technology Data Exchange (ETDEWEB)

    Agrawal, Shweta; Singh, Bhaskar; Sharma, Yogesh C. [Banaras Hindu University, Department of Applied Chemistry, Institute of Technology, Varanasi (India); Frometa, Amado Enrique N. [Universidad Tecnologica de Izucar de Matamoros, Puebla (Mexico)

    2012-12-15

    Commercial-grade limestone used in whitewashing which is a low-cost material has been used as a catalyst for the synthesis of fatty acid methyl esters. The catalyst was characterized by differential thermal analysis/thermogravimetric analysis, X-ray diffraction, and Fourier transform infrared spectroscopy for the study of its physicochemical nature. The catalyst was calcined at 900 C for 2.5 h for the decomposition of calcium carbonate to calcium oxide. The catalyst was further activated by dissolving 1.5 wt% of catalyst in 30 ml methanol (7.5:1, methanol to used frying oil molar ratio) and stirred at 25 C for 1 h on a magnetic stirrer. The transesterification reaction was performed using calcium oxide as a catalyst and then with the ''activated calcium oxide.'' The conversion obtained was 94.4 % with calcium oxide and was found to be lower for the ''activated calcium oxide'' (i.e., 87.36 %). The conversion increased to 96.8 % on increasing the catalyst amount to 2.0 wt% in 5 h. A high yield (>95 %) of fatty acid methyl esters was observed when either calcium oxide or ''activated calcium oxide'' was taken as catalyst. The catalytic activity of calcium oxide obtained from low-grade limestone has been found to be comparable with the laboratory-grade CaO. (orig.)

  20. Crystal and magnetic study of the disordered perovskites Ca(Mn{sub 0.5}Sb{sub 0.5})O{sub 3} and Ca(Fe{sub 0.5}Sb{sub 0.5})O{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Retuerto, M., E-mail: mretuerto@icmm.csic.es [Instituto de Ciencia de Materiales de Madrid, CSIC, Energia, Medio Ambiente y Tecnologias Sostenibles, Sor Juana Ines de la Cruz 3, Cantoblanco, E-28049 Madrid (Spain); Martinez-Lope, M.J.; Garcia-Hernandez, M. [Instituto de Ciencia de Materiales de Madrid, CSIC, Energia, Medio Ambiente y Tecnologias Sostenibles, Sor Juana Ines de la Cruz 3, Cantoblanco, E-28049 Madrid (Spain); Munoz, A. [Departamento de Fisica Aplicada, EPS, Universidad Carlos III, Avda. Universidad 30, E-28911 Leganes-Madrid (Spain); Fernandez-Diaz, M.T. [Institut Max Von Laue Paul Langevin, F-38042 Grenoble (France); Alonso, J.A. [Instituto de Ciencia de Materiales de Madrid, CSIC, Energia, Medio Ambiente y Tecnologias Sostenibles, Sor Juana Ines de la Cruz 3, Cantoblanco, E-28049 Madrid (Spain)

    2010-10-15

    We have investigated the double perovskites Ca{sub 2}MSbO{sub 6} (M = Mn, Fe) that have been prepared by solid-state reaction (M = Fe) and wet chemistry procedures (M = Mn). The crystal and magnetic structures have been studied from X-ray (XRD) and neutron powder diffraction (NPD) data. Rietveld refinements show that the crystal structures are orthorhombic (space group Pbnm) with complete disorder of M and Sb cations, so the formula should be rewritten as Ca(M{sub 0.5}Sb{sub 0.5})O{sub 3}. Due to this disorder no evidences of Jahn-Teller distortion can be observed in the MnO{sub 6} octahedra of Ca(Mn{sub 0.5}Sb{sub 0.5})O{sub 3}, in contrast with the ordered double perovskite Sr{sub 2}MnSbO{sub 6}. Ca(Fe{sub 0.5}Sb{sub 0.5})O{sub 3} behaves as an antiferromagnet with an ordered magnetic moment for Fe{sup 3+} of 1.53(4){mu}{sub B} and a propagation vector k = 0, as investigated by low-temperature NPD. The antiferromagnetic ordering is a result of the high degree of Fe/Sb anti-site disorder of the sample, which originates the spontaneous formation of Fe-rich islands, characterized by the presence of strong Fe-O-Fe antiferromagnetic couplings with enough long-range coherence to produce a magnetic contribution perceptible by NPD. By contrast, the magnetic structure of Ca(Mn{sub 0.5}Sb{sub 0.5})O{sub 3} cannot be observed by low-temperature NPD because the magnitude of the ordered magnetic moments is below the detection threshold for neutrons.

  1. In vivo study of nanostructured diopside (CaMgSi{sub 2}O{sub 6}) coating on magnesium alloy as biodegradable orthopedic implants

    Energy Technology Data Exchange (ETDEWEB)

    Razavi, Mehdi, E-mail: mrzavi2659@gmail.com [Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111 (Iran, Islamic Republic of); Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 81746-73461 (Iran, Islamic Republic of); School of Materials Science and Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK 74106 (United States); School of Electrical and Computer Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK 74106 (United States); Fathi, Mohammadhossein [Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111 (Iran, Islamic Republic of); Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan (Iran, Islamic Republic of); Savabi, Omid [Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 81746-73461 (Iran, Islamic Republic of); Razavi, Seyed Mohammad [School of Dentistry, Isfahan University of Medical Sciences, Isfahan 81746-73461 (Iran, Islamic Republic of); Heidari, Fariba; Manshaei, Maziar [Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 81746-73461 (Iran, Islamic Republic of); Vashaee, Daryoosh [School of Electrical and Computer Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK 74106 (United States); Tayebi, Lobat, E-mail: lobat.tayebi@okstate.edu [School of Materials Science and Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK 74106 (United States); School of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078 (United States)

    2014-09-15

    Highlights: • In vitro biocompatibility of biodegradable Mg alloy was improved by diopside coating. • In vivo biocompatibility of biodegradable Mg alloy was improved by diopside coating. • Degradation behavior of biodegradable Mg alloy was improved by diopside coating. - Abstract: In order to improve the corrosion resistance and bioactivity of a biodegradable magnesium alloy, we have recently prepared a nanostructured diopside (CaMgSi{sub 2}O{sub 6}) coating on AZ91 magnesium alloy through a combined micro-arc oxidation (MAO) and electrophoretic deposition (EPD) method (reported elsewhere). In this work, we performed a detailed biocompatibility analysis of the implants made by this material and compared their performance with those of the uncoated and micro arc oxidized magnesium implants. The biocompatibility evaluation of samples was performed by culturing L-929 cells and in vivo animal study, including implantation of samples in greater trochanter of rabbits, radiography and histological examinations. The results from both the in vitro and in vivo studies indicated that the diopside/MAO coated magnesium implant significantly enhanced cell viability, biodegradation resistance and new bone formation compared with both the uncoated and the micro-arc oxidized magnesium implants. Our data provides an example of how the proper surface treatment of magnesium implants can overcome their drawbacks in terms of high degradation rate and gas bubble formation under physiological conditions.

  2. Thermoluminescence and photoluminescence study of nanocrystalline Ba{sub 0.97}Ca{sub 0.03}SO{sub 4} : Eu

    Energy Technology Data Exchange (ETDEWEB)

    Lochab, S P [Inter-University Accelerator Centre, Aruna Asaf Ali Marg, New Delhi-110067 (India); Sahare, P D [Department of Physics and Astrophysics, University of Delhi, Delhi-110007 (India); Chauhan, R S [Department of Physics, R B S College, B R Ambedkar University, Agra-282002 (India); Salah, Numan [Department of Physics, Faculty of Applied Sciences, Thamar University, PO Box 87246, Thamar (Yemen); Ranjan, Ranju [Department of Physics and Astrophysics, University of Delhi, Delhi-110007 (India); Pandey, A [Department of Physics, Sri Venkateswara College, University of Delhi, Benito Juarez Road, Dhaula Kuan, New Delhi-110021 (India)

    2007-03-07

    Nanocrystalline Ba{sub 0.97}Ca{sub 0.03}SO{sub 4} : Eu having a grain size of 58 nm has been prepared and a comparative study has been done with its corresponding microcrystalline form. The thermoluminescence (TL) glow curve of the nanophosphor has a prominent peak at 161 deg. C and a very small hump at 225 deg. C. The TL sensitivity of the nanophosphor is about 0.1 times that of the microphosphor. Kinetics parameters of the TL peaks of the nanophosphor are obtained and are compared with those of the microphosphor. The TL response of the nanophosphor is linear in the dose range 1 Gy-20 KGy, which is much wider than that of its corresponding microcrystalline form. The glow curve shape and structure also do not change in the linear dose range and, since the TL response is linear at higher doses, the nanophosphor is quite well suited for high dose measurements. Photoluminescence emission spectra of the nano- and the microphosphors are also studied and their results correlated with other experimental findings.

  3. In vivo study of nanostructured diopside (CaMgSi2O6) coating on magnesium alloy as biodegradable orthopedic implants

    International Nuclear Information System (INIS)

    Razavi, Mehdi; Fathi, Mohammadhossein; Savabi, Omid; Razavi, Seyed Mohammad; Heidari, Fariba; Manshaei, Maziar; Vashaee, Daryoosh; Tayebi, Lobat

    2014-01-01

    Highlights: • In vitro biocompatibility of biodegradable Mg alloy was improved by diopside coating. • In vivo biocompatibility of biodegradable Mg alloy was improved by diopside coating. • Degradation behavior of biodegradable Mg alloy was improved by diopside coating. - Abstract: In order to improve the corrosion resistance and bioactivity of a biodegradable magnesium alloy, we have recently prepared a nanostructured diopside (CaMgSi 2 O 6 ) coating on AZ91 magnesium alloy through a combined micro-arc oxidation (MAO) and electrophoretic deposition (EPD) method (reported elsewhere). In this work, we performed a detailed biocompatibility analysis of the implants made by this material and compared their performance with those of the uncoated and micro arc oxidized magnesium implants. The biocompatibility evaluation of samples was performed by culturing L-929 cells and in vivo animal study, including implantation of samples in greater trochanter of rabbits, radiography and histological examinations. The results from both the in vitro and in vivo studies indicated that the diopside/MAO coated magnesium implant significantly enhanced cell viability, biodegradation resistance and new bone formation compared with both the uncoated and the micro-arc oxidized magnesium implants. Our data provides an example of how the proper surface treatment of magnesium implants can overcome their drawbacks in terms of high degradation rate and gas bubble formation under physiological conditions

  4. Correlation between non-Fermi-liquid behavior and superconductivity in (Ca, La)(Fe,Co)As2 iron arsenides: A high-pressure study

    Science.gov (United States)

    Zhou, W.; Ke, F.; Xu, Xiaofeng; Sankar, R.; Xing, X.; Xu, C. Q.; Jiang, X. F.; Qian, B.; Zhou, N.; Zhang, Y.; Xu, M.; Li, B.; Chen, B.; Shi, Z. X.

    2017-11-01

    Non-Fermi-liquid (NFL) phenomena associated with correlation effects have been widely observed in the phase diagrams of unconventional superconducting families. Exploration of the correlation between the normal state NFL, regardless of its microscopic origins, and the superconductivity has been argued as a key to unveiling the mystery of the high-Tc pairing mechanism. Here we systematically investigate the pressure-dependent in-plane resistivity (ρ ) and Hall coefficient (RH) of a high-quality 112-type Fe-based superconductor Ca1 -xLaxFe1 -yCoyAs2 (x =0.2 ,y =0.02 ). With increasing pressure, the normal-state resistivity of the studied sample exhibits a pronounced crossover from non-Fermi-liquid to Fermi-liquid behaviors. Accompanied with this crossover, Tc is gradually suppressed. In parallel, the extremum in the Hall coefficient RH(T ) curve, possibly due to anisotropic scattering induced by spin fluctuations, is also gradually suppressed. The symbiosis of NFL and superconductivity implies that these two phenomena are intimately related. Further study on the pressure-dependent upper critical field reveals that the two-band effects are also gradually weakened with increasing pressure and reduced to the one-band Werthamer-Helfand-Hohenberg limit in the low-Tc regime. Overall, our paper supports the picture that NFL, multigap, and extreme RH(T ) are all of the same magnetic origin, i.e., the spin fluctuations in the 112 iron arsenide superconductors.

  5. Understanding the origin of photoluminescence in disordered Ca0.60Sr0.40WO4: An experimental and first-principles study

    International Nuclear Information System (INIS)

    Longo, V.M.; Orhan, E.; Cavalcante, L.S.; Porto, S.L.; Espinosa, J.W.M.; Varela, J.A.; Longo, E.

    2007-01-01

    Visible photoluminescence (PL) was observed for the first time at room temperature in structurally disordered calcium strontium tungstate powder, Ca 0.60 Sr 0.40 WO 4 (CSW), obtained by the polymeric precursor method. The PL behavior of CSW powders has been analyzed as a function of the disorder rate, based on experimental and theoretical studies. Quantum mechanical theory based on density functional theory at the B3LYP level has been employed to study the electronic structure of two periodic models representing both crystalline and disordered powders. Their electronic structures have been analyzed in terms of density of states, band dispersion and charge densities. The calculations indicate a break in symmetry when passing from crystalline to disordered models, creating localized electronic levels above the valence band. Moreover, a negative charge transfer process takes place from the [WO 3 ] cluster to the [WO 4 ] cluster. The polarization induced by the break in symmetry and the existence of localized levels favors the creation of trapped holes and electrons, originating the PL phenomenon

  6. Structural study of Al2O3-Na2O-CaO-P2O5 bioactive glasses as a function of aluminium content.

    Science.gov (United States)

    Smith, J M; King, S P; Barney, E R; Hanna, J V; Newport, R J; Pickup, D M

    2013-01-21

    Calcium phosphate based biomaterials are extensively used in the context of tissue engineering: small changes in composition can lead to significant changes in properties allowing their use in a wide range of applications. Samples of composition (Al(2)O(3))(x)(Na(2)O)(0.11-x)(CaO)(0.445)(P(2)O(5))(0.445), where x = 0, 0.03, 0.05, and 0.08, were prepared by melt quenching. The atomic-scale structure has been studied using neutron diffraction and solid state (27)Al MAS NMR, and these data have been rationalised with the determined density of the final glass product. With increasing aluminium concentration the density increases initially, but beyond about 3 mol. % Al(2)O(3) the density starts to decrease. Neutron diffraction data show a concomitant change in the aluminium speciation, which is confirmed by (27)Al MAS NMR studies. The NMR data reveal that aluminium is present in 4, 5, and 6-fold coordination and that the relative concentrations of these environments change with increasing aluminium concentration. Materials containing aluminium in 6-fold coordination tend to have higher densities than analogous materials with the aluminium found in 4-fold coordination. Thus, the density changes may readily be explained in terms of an increase in the relative concentration of 4-coordinated aluminium at the expense of 6-fold aluminium as the Al(2)O(3) content is increased beyond 3 mol. %.

  7. Evaluation of CA-125 and soluble CD-23 in patients with pelvic endometriosis: a case-control study Avaliação do CA-125 e CD-23 solúvel em pacientes com endometriose pélvica: estudo de caso-controle

    Directory of Open Access Journals (Sweden)

    Ivana Maria de Luna Ramos

    2012-02-01

    Full Text Available OBJECTIVE: To evaluate serum concentrations of CA-125 and soluble CD-23 and to correlate them with clinical symptoms, localization and stage of pelvic endometriosis and histological classification of the disease. METHODS: Blood samples were collected from 44 women with endometriosis and 58 without endometriosis, during the first three days (1st sample and during the 7th, 8th and 9th day (2nd sample of the menstrual cycle. Measurements of CA-125 and soluble CD-23 were performed by ELISA. Mann-Whitney U test was used for age, pain evaluations (visual analog scale and biomarkers concentrations. RESULTS: Serum levels of CA125 were higher in endometriosis patients when compared to the control group during both periods of the menstrual cycle evaluated in the study. This marker was also elevated in women with chronic pelvic pain, deep dyspareunia (2nd sample, dysmenorrhea (both samples and painful defecation during the menstrual flow (2nd sample. CA-125 concentration was higher in advanced stages of the disease in both samples and also in women with ovarian endometrioma. Concerning CD-23, no statistically significant differences were observed between groups. CONCLUSION: The concentrations of CA-125 were higher in patients with endometriosis than in patients without the disease. No significantly differences were observed for soluble CD-23 levels between groups.OBJETIVO: Avaliar as concentrações séricas de CA-125 e CD-23 solúvel e correlacioná-los com sintomas clínicos, localização e estádio da endometriose pélvica e classificação histológica da doença. MÉTODOS: Amostras de sangue foram coletadas de 44 mulheres com endometriose e 58 sem endometriose durante os primeiros três dias (1ª amostra e durante o sétimo, o oitavo e o nono dia (2ª amostra do ciclo menstrual. As dosagens de CA-125 e CD-23 solúvel foram realizadas por ELISA. O teste U de Mann-Whitney foi usado para idade, avaliação de dor (escala analógica visual e para a

  8. Ca adsorption on dickite, Sericite and quartz. Dickite, sericite oyobi sekiei ni taisuru Ca no kyuchaku

    Energy Technology Data Exchange (ETDEWEB)

    Matsuoka, Isao; Nozawa, Miki (Tohoku Univ., Sendai, (Japan). Faculty of Engineering)

    1990-02-25

    Ca adsorbing characteristics of dickite were studied to clarify the possibility of clay minerals on selective Ca activation. Ca adsorption on hydrogenated dickite was compared with those of Na {sup +} and K {sup +} and further, the comparison was made for adsorption of Ca and these ikns on quartz and hydrogenated sericite. Ca adsorption on quartz which is thought to be caused by the negative charge of broken bond, depends strongly on pH and for pH of 7 or more, Ca acts strongly on any quartz surface. Moreover, when Na {sup +} or K {sup +} coexists, the effect of coexisting ion on Ca adsorption does not result any difference. On the contrary, Ca adsorption on sericite is mainly caused by the exchanging adsorption with H {sup +} and Ca saturated adsortion does not depend on pH in the range of 4-10pH. But Na {sup +} adsorption does not reach the saturation for lower pH unless Na {sup +} of sufficient concentration exists. 13 refs., 16 figs.

  9. Reduction of radiation biases by incorporating the missing cloud variability by means of downscaling techniques: a study using the 3-D MoCaRT model

    Directory of Open Access Journals (Sweden)

    S. Gimeno García

    2012-09-01

    Full Text Available Handling complexity to the smallest detail in atmospheric radiative transfer models is unfeasible in practice. On the one hand, the properties of the interacting medium, i.e., the atmosphere and the surface, are only available at a limited spatial resolution. On the other hand, the computational cost of accurate radiation models accounting for three-dimensional heterogeneous media are prohibitive for some applications, especially for climate modelling and operational remote-sensing algorithms. Hence, it is still common practice to use simplified models for atmospheric radiation applications.

    Three-dimensional radiation models can deal with complex scenarios providing an accurate solution to the radiative transfer. In contrast, one-dimensional models are computationally more efficient, but introduce biases to the radiation results.

    With the help of stochastic models that consider the multi-fractal nature of clouds, it is possible to scale cloud properties given at a coarse spatial resolution down to a higher resolution. Performing the radiative transfer within the cloud fields at higher spatial resolution noticeably helps to improve the radiation results.

    We present a new Monte Carlo model, MoCaRT, that computes the radiative transfer in three-dimensional inhomogeneous atmospheres. The MoCaRT model is validated by comparison with the consensus results of the Intercomparison of Three-Dimensional Radiation Codes (I3RC project.

    In the framework of this paper, we aim at characterising cloud heterogeneity effects on radiances and broadband fluxes, namely: the errors due to unresolved variability (the so-called plane parallel homogeneous, PPH, bias and the errors due to the neglect of transversal photon displacements (independent pixel approximation, IPA, bias. First, we study the effect of the missing cloud variability on reflectivities. We will show that the generation of subscale variability by means of stochastic

  10. New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors.

    Science.gov (United States)

    Gul, Halise Inci; Yamali, Cem; Sakagami, Hiroshi; Angeli, Andrea; Leitans, Janis; Kazaks, Andris; Tars, Kaspars; Ozgun, Dilan Ozmen; Supuran, Claudiu T

    2018-04-01

    In this study, new 4-[3-(aryl)-5-substitutedphenyl-4,5-dihydro-1H-pyrazole-1-yl]benzensulfonamides (19-36) were synthesized and evaluated their cytotoxic/anticancer and CA inhibitory effects. According to results obtained, the compounds 34 (4-[5-(2,3,4-trimethoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-yl] benzensulfonamide, Potency-Selectivity Expression (PSE) = 141) and 36 (4-[5-(3,4,5-trimethoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-yl]benzensulfonamide, PSE = 54.5) were found the leader anticancer compounds with the highest PSE values. In CA inhibitory studies, the compounds 36 and 24 (4-[5-(3,4,5-trimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-yl]benzensulfonamide) were found the leader CA inhibitors depending on selectivity ratios. The compound 36 was a selective inhibitor of hCA XII isoenzyme (hCA I/hCA XII = 1250 and hCA II/hCA XII = 224) while the compound 24 was a selective inhibitor of hCA IX isoenzyme (hCA I/hCA IX = 161 and hCA II/hCA IX = 177). The compounds 24, 34, and 36 can be considered to develop new anticancer drug candidates. Copyright © 2018 Elsevier Inc. All rights reserved.

  11. Corrosion study on high power feeding of telecomunication copper cable in 5 wt.% CaSO4.2H2O solution

    Science.gov (United States)

    Shamsudin, Shaiful Rizam; Hashim, Nabihah; Ibrahim, Mohd Saiful Bahri; Rahman, Muhammad Sayuzi Abdul; Idrus, Muhammad Amin; Hassan, Mohd Rezadzudin; Abdullah, Wan Razli Wan

    2016-07-01

    The studies were carried out to find out the best powering scheme over the copper telephone line. It was expected that the application of the higher power feeding could increase the data transfer and capable of providing the customer's satisfaction. To realize the application of higher remote power feeding, the potential of corrosion problem on Cu cables was studied. The natural corrosion behaviour of copper cable in the 0.5% CaSO4.2H2O solution was studied in term of open circuit potential for 30 days. The corrosion behaviour of higher power feeding was studied by the immersion and the planned interval test to determine the corrosion rate as well as the effect of voltage magnitudes and the current scheme i.e. positive direct (DC+) and alternating current (AC) at about 0.40 ± 0.01 mA/ cm2 current density. In the immersion test, both DC+ and AC scheme showed the increasing of feeding voltage magnitude has increased the corrosion rate of Cu samples starting from 60 to 100 volts. It was then reduced at about 100 - 120 volts which may due to the passive and transpassive mechanism. The corrosion rate was slowly reduced further from 120 to 200 volts. Visually, the positively charged of Cu cable was seems susceptible to severe corrosion, while AC scheme exhibited a slight corrosion reaction on the surface. However, the planned interval test and XRD results showed the corrosion activity of the copper cable in the studied solution was a relatively slow process and considered not to be corroded as a partially protective scale of copper oxide formed on the surface.

  12. Local Structure of Mn in (La1-xHox)2/3Ca1/3MnO3 Studied by X-ray Absorption Fine Structure

    International Nuclear Information System (INIS)

    Pietnoczka, A.; Bacewicz, R.; Antonowicz, J.; Zalewski, W.; Pekala, M.; Drozd, V.; Fagnard, J.F.; Vanderbemden, P.

    2010-01-01

    Results of X-ray absorption fine structure measurements in manganites (La 1-x Ho x ) 2/3 Ca 1/3 MnO 3 with 0.15 3 is doped with a divalent element such as Ca 2+ , substituting for La 3+ , holes are induced in the filled Mn d orbitals. This leads to a strong ferromagnetic coupling between Mn sites. Ca ions in La 1-x Ca x MnO 3 introduce a distortion of the crystal lattice and mixed valence Mn ions (Mn 3+ and Mn 4+ ). On the other hand, in manganites (La 1-x Ho x ) 2/3 Ca 1/3 MnO 3 the substitution of La for Ho causes a lattice distortion and induces a disorder, which reduces a magnetic interaction. The ferromagnetic transition temperature and conductivity decrease very quickly with increasing x. The magnetic and transport properties of compounds depend on the local atomic structure around Mn ions. The information on the bond lengths and Debye-Waller factor are obtained from the extended X-ray absorption fine structure (EXAFS) data analysis. The charge state of Mn is determined from the position of the absorption edge in X-ray absorption near edge structure (XANES) data. XAFS results are in good agreement with magnetic characteristics of the studied materials. (authors)

  13. CaMKII: linking heart failure and arrhythmias

    Science.gov (United States)

    Swaminathan, Paari Dominic; Purohit, Anil; Hund, Thomas J; Anderson, Mark E

    2013-01-01

    Understanding relationships between heart failure and arrhythmias, important causes of suffering and sudden death, remains an unmet goal for biomedical researchers and physicians. Evidence assembled over the last decade supports a view that activation of the multifunctional Ca2+ and calmodulin-dependent protein kinase II (CaMKII) favors myocardial dysfunction and cell membrane electrical instability. CaMKII activation follows increases in intracellular Ca2+ or oxidation, upstream signals with the capacity to transition CaMKII into a Ca2+ and calmodulin-independeant, constitutively active enzyme. Constitutively active CaMKII appears poised to participate in disease pathways by catalyzing the phosphorylation of classes of protein targets important for excitation-contraction coupling and cell survival, including ion channels and Ca2+ homeostatic proteins, and transcription factors that drive hypertrophic and inflammatory gene expression. This rich diversity of downstream targets helps to explain the potential for CaMKII to simultaneously affect mechanical and electrical properties of heart muscle cells. Proof of concept studies from a growing number of investigators show that CaMKII inhibition is beneficial for improving myocardial performance and reducing arrhythmias. Here we review the molecular physiology of CaMKII, discuss CaMKII actions at key cellular targets and results of animal models of myocardial hypertrophy, dysfunction and arrhythmias that suggest CaMKII inhibition may benefit myocardial function while reducing arrhythmias. PMID:22679140

  14. IP3 stimulates CA++ efflux from fusogenic carrot protoplasts

    International Nuclear Information System (INIS)

    Rincon, M.; Boss, W.F.

    1986-01-01

    Polyphosphoinositide breakdown plays an important role in signal transduction in animal cells (Berridge and Irvine, 1984, Nature, 312:315). Upon stimulation, phospholipase C hydrolyzes phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate (IP 3 ) and diacylglycerol both of which act as cellular second messengers. IP 3 mobilizes Ca ++ from internal stores, hence the cytosolic free Ca ++ concentration increases and those physiological activities regulated by Ca ++ are stimulated. To test if plant cells also responded to IP 3 , Ca ++ efflux studies were done with fusogenic carrot protoplasts released in EGTA. The protoplasts were preloaded with 45 Ca ++ placed in a Ca ++ -free medium, and efflux determined as 45 Ca ++ loss from the protoplasts. IP 3 (10-20μM) caused enhanced 45 Ca ++ efflux and the response was sustained for at least 15 min. In plants, as in animals, the observed IP 3 -enhanced 45 Ca ++ efflux suggested that IP 3 released Ca ++ from internal stores, and the increased free cytosolic Ca ++ activated Ca ++ pumping mechanisms which restored the Ca ++ concentration in the cytosol to the normal level

  15. High-resolution angle-resolved photoemission studies of high Tc superconductor Bi2Sr2CaCu2O8

    International Nuclear Information System (INIS)

    Liu, Rong.

    1990-01-01

    An angle-resolved photoemission study of the normal and superconducting states in Bi 2 Sr 2 CaCu 2 O 8 was performed. Measurements in the normal state show bands dispersing through the Fermi level from at least 350 meV below E F . The Fermi level crossings are consistant with local-density band calculation, including a point calculated to be of Bi-O character. Additional measurements were made where bands crossed the Fermi level between 100 and 250K, along with measurements on an adjacent Pt foil. The Fermi edges of both materials agree to within the noise. Below the Fermi level, the spectra show correlation effects on the form of an increased effective mass. The shape of the spectra can be explained by a lifetime-broadened photohole and secondary electrons. The effective inverse photohole lifetime is linear in energy. A superconducting gap has been measured at a number of points where there is density at the Fermi level in the normal state. By proper modeling, a gap of 24 meV was obtained for all these points, including points of Cu-O and Bi-O character respectively, according to band calculation. The lack of gap anisotropy in the basal plane suggests that pinning in this material is not d-wave pairing

  16. H2-assisted CO2 thermochemical reduction on La0.9Ca0.1FeO3-δ membranes: a kinetics study

    KAUST Repository

    Wu, Xiao-Yu

    2017-11-04

    Kinetics data for CO2 thermochemical reduction in an isothermal membrane reactor is required to identify the rate-limiting steps. Here, we report a detailed reaction kinetics study on this process supported by an La0.9Ca0.1FeO3-δ (LCF-91) membrane. The dependence of CO2 reduction rate on various operating conditions is examined such as CO2 concentration on the feed side, fuel concentrations on the sweep side and temperatures. CO2 reduction rate is proportional to the oxygen flux across the membrane, and the measured maximum fluxes are 0.191 and 0.164 μmol cm-2 s-1 with 9.5% H2 and 11.6% CO on the sweep side at 990oC, respectively. Fuel is used to maintain the chemical potential gradient across the membrane and CO is used by construction to derive the surface reaction kinetics. This membrane also exhibits stable performances for 106 hours. A resistance-network model is developed to describe the oxygen transport process and the kinetics data are parameterized using the experimental values. The model shows a transition of the rate limiting step between the surface reactions on the feed side and the sweep side depending on the operating conditions.

  17. A Brillouin scattering study of La0.77Ca0.23MnO3 across the metal-insulator transition

    International Nuclear Information System (INIS)

    Seikh, Md Motin; Narayana, Chandrabhas; Sudheendra, L; Sood, A K; Rao, C N R

    2004-01-01

    Temperature-dependent Brillouin scattering studies have been carried out on La 0.77 Ca 0.23 MnO 3 across the paramagnetic insulator-ferromagnetic metal (I-M) transition (T C ∼ 230 K). The spectra show modes corresponding to a surface Rayleigh wave (SRW) and a high velocity pseudo-surface wave (HVPSAW) along with bulk acoustic waves (B1 and B2). The Brillouin shifts associated with the SRW and HVPSAW increase, whereas the B1 and B2 frequencies decrease, below T C . The temperature dependence of the SRW and HVPSAW modes is related to the increase in the elastic constant C 11 across the I-M transition. The decrease in frequency across the I-M transition of the bulk modes is understood to be due to enhanced self-energy corrections as a result of increased magnon-phonon interaction across the I-M transition. Correspondingly, these modes show a large increase in the full width at half maximum (FWHM) as the temperature decreases. We also observe a central peak whose width is maximum at T C

  18. Diverse trends of electron correlation effects for properties with different radial and angular factors in an atomic system: a case study in Ca+

    Science.gov (United States)

    Kumar, Pradeep; Li, Cheng-Bin; Sahoo, B. K.

    2018-03-01

    Dependencies of electron correlation effects with the rank and radial behavior of spectroscopic properties are analyzed in the singly charged calcium ion (Ca+). To demonstrate these trends, we have determined field shift constants, magnetic dipole and electric quadrupole hyperfine structure constants, Landé g J factors, and electric quadrupole moments that are described by electronic operators with different radial and angular factors. Radial dependencies are investigated by comparing correlation trends among the properties that have similar angular factors and vice versa. To highlight these observations, we present results from the mean-field approach to all-orders along with intermediate contributions. Contributions from higher relativistic corrections are also given. These findings suggest that sometime lower-order approximations can give results agreeing with the experimental results, but inclusion of some of higher-order correlation effects can cause large disagreement with the experimental values. Therefore, validity of a method for accurate evaluation of atomic properties can be tested by performing calculations of several properties simultaneously that have diverse dependencies on the angular and radial factors and comparing with the available experimental results. Nevertheless, it is imperative to include full triple and quadrupole excitations in the all-order many-body methods for high-precision calculations that are yet to be developed adopting spherical coordinate system for atomic studies.

  19. Study of Coxsackie B viruses interactions with Coxsackie Adenovirus receptor and Decay-Accelerating Factor using Human CaCo-2 cell line.

    Science.gov (United States)

    Riabi, Samira; Harrath, Rafik; Gaaloul, Imed; Bouslama, Lamjed; Nasri, Dorsaf; Aouni, Mahjoub; Pillet, Sylvie; Pozzetto, Bruno

    2014-05-21

    Decay Accelerating Factor (DAF) and Coxsackievirus-Adenovirus Receptor (CAR) have been identified as cellular receptors for Coxsackie B viruses (CV-B). The aim of this study is to elucidate the different binding properties of CV-B serotypes and to find out if there are any amino acid changes that could be associated to the different phenotypes.Twenty clinical CV-B isolates were tested on CaCo-2 cell line using anti-DAF (BRIC216) and anti-CAR (RmcB) antibodies. CV-B3 Nancy prototype strain and a recombinant strain (Rec, CV-B3/B4) were tested in parallel. The P1 genomic region of 12 CV-B isolates from different serotypes was sequenced and the Trans-Epithelial Electrical Resistance (TEER) along with the virus growth cycle was measured. Infectivity assays revealed clear differences between CV-B isolates with regard to their interactions with DAF and CAR. All tested CV-B isolates showed an absolute requirement for CAR but varied in their binding to DAF. We also reported that for some isolates of CV-B, DAF attachment was not adapted. Genetic analysis of the P1 region detected multiple differences in the deduced amino acid sequences. Within a given serotype, variations exist in the capacity of virus isolates to bind to specific receptors, and variants with different additional ligands may arise during infection in humans as well as in tissue culture.

  20. Effect of Ca content on equilibrium Ca isotope fractionation between orthopyroxene and clinopyroxene

    Science.gov (United States)

    Wang, Wenzhong; Zhou, Chen; Qin, Tian; Kang, Jin-Ting; Huang, Shichun; Wu, Zhongqing; Huang, Fang

    2017-12-01

    Concentration effect on equilibrium inter-mineral isotope fractionation is ubiquitous in solid solution systems, but it is not clear in which concentration range such effect is prominent. Using first-principles calculations, we examine the effect of Ca and Fe contents in orthopyroxene (opx) on its average Casbnd O bond length and the equilibrium Ca isotope fractionation factor (103lnα) between opx and clinopyroxene (cpx). Our results reveal that the average Casbnd O bond length in opx is much smaller than that in cpx and it does not change with variable Ca content x (x and y are mole ratios in CaxFeyMg1-x-ySiO3 thereafter here) when x ≤ 1/48. Incorporation of Fe (y ≥ 1/32) into opx with a fixed Ca content can only slightly increase the average Casbnd O bond length. 103lnαopx-cpx of 44Ca/40Ca is linearly correlated with the average Casbnd O bond length in opx, suggesting that 103lnαopx-cpx of 44Ca/40Ca is controlled by opx Casbnd O bond strength. Our calculations indicate that the Ca concentration effect on 103lnαopx-cpx is significant when x in opx ranges from 2/16 to 1/48, while Fe in natural opx only causes a slight decrease in 103lnαopx-cpx. Our results provide insights into Ca isotope fractionation in high-temperature geochemical processes. Given that Ca content x in opx from natural peridotites is usually lower than 1/32 and Fe content y is generally ∼10 mol%, Ca and Fe concentration effects on 103lnαopx-cpx in natural samples are negligible. Rather, 103lnαopx-cpx is mainly controlled by temperature. 103lnαopx-cpx of 44Ca/40Ca decreases from 0.50‰ to 0.26‰ when temperature increases from 1000 K to 1400 K if the Fe effect is taken into account. Therefore, if Ca isotope fractionation between opx and cpx (Δ44/40Caopx-cpx) in natural peridotites is greater than 0.50‰ or lower than 0.26‰, it may indicate disequilibrium of Ca isotopes. Finally, the large 103lnαopx-cpx relative to our current analytical precision suggests that Δ44/40Caopx

  1. Panax ginseng C.A Meyer root extract for moderate Chronic Obstructive Pulmonary Disease (COPD: study protocol for a randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Story David

    2011-06-01

    Full Text Available Abstract Background Chronic obstructive pulmonary disease (COPD impairs quality of life and leads to premature mortality. COPD sufferers experience progressive deterioration of lung function and decreased ability to undertake day-to-day activities. Ginseng has been used for thousands of years in Chinese medicine for respiratory symptoms. Several controlled clinical trials using ginseng for COPD have shown promising clinical effect, however these studies were generally small and with some potential bias, prompting the need for rigorously designed studies. Aim The objective of this study is to evaluate the therapeutic value and safety profile of a standardised root extract of Panax ginseng C.A Meyer (ginseng for symptomatic relief, with a focus on quality of life (QoL improvements in individuals with moderate (Stage II COPD FEV1/FVC 1 50% - 80% predicted. Methods This paper describes the design of a randomised, multi-centre, double-blind, placebo controlled, two-armed parallel clinical trial. Two trial sites in Melbourne Australia will proportionately randomise a total of 168 participants to receive either ginseng capsule (100 mg or matching placebo twice daily for 24 weeks. The primary outcomes will be based on three validated QoL questionnaires, St Georges Respiratory Questionnaire (SGRQ, Short Form Health Survey (SF-36 and the COPD Assessment Test (CAT. Secondary outcomes are based on lung function testing, relief medication usage and exacerbation frequency and severity. Safety endpoints include blood tests and adverse event reporting. Intention-to-treat will be applied to all data analyses. Discussion Findings from this study may lead to new therapeutic development for chronic respiratory diseases, particularly COPD. This protocol may also guide other investigators to develop quality herbal medicine clinical trials in the future. Trial registration Australia and New Zealand Clinical Trials Register (ANZCTR: ACTRN12610000768099

  2. Some aspects of hormone-directed transport of mineral elements (P,S,Ca,Cl) in plants studied by means of radioactive tracers

    International Nuclear Information System (INIS)

    Penot, M.

    1979-01-01

    Hormone-directed long-distance transport was studied on a simplified model - a detached leaf of Pelargonium zonale. The special interest of this model is that it is the only system on which it is possible to determine, simultaneously on the same specimen, the effects of hormone dose, competitivity and synergy. It is shown that various hormones (auxins, gibberellins, cytokinins) have a positive effect on the migration of S, P and Rb; on the other hand, no effect is detected in the case of Ca, Cl or Mo. The orientated migration and subsequent accumulation are functions of the locally applied hormone dose. GA 3 (gibberellic acid) seems to be the most efficient (action threshold: 0.025 mg.1 -1 ). A simultaneous study on the same specimen showed that the mixture AIA (β-indole acetic acid)+BAP (benzylaminopurine)+GA 3 has a greater effect on transport than GA 3 alone, while GA 3 alone has a more pronounced antisenescent effect; this indicates that the two processes are not connected. Likewise, a parallel study showed that there is no direct connection with the transpiratory flows; fusicoccin, which stimulates stomata opening, has no attractant effect for 35 S while GA 3 , which has a very strong effect on migration, does not modify the transpiratory losses. Investigation of the response times shows that the ionic displacements through the phloem may be very fast (abundant accumulation in the petiole in less than 10 minutes) but that the attractant effect cannot be detected below thresholds of 5 hours or 90 minutes respectively for the pre-treatment and transport phases. This simplified system would appear to be an excellent model for studying other parameters involved in transport (effect of the root system and the relative importance of the processes of loading or unloading of metabolites in the phloem). (author)

  3. A field studies and modeling approach to develop organochlorine pesticide and PCB total maximum daily load calculations: Case study for Echo Park Lake, Los Angeles, CA

    Energy Technology Data Exchange (ETDEWEB)

    Vasquez, V.R., E-mail: vrvasquez@ucla.edu [Environmental Science and Engineering Program, University of California, Los Angeles, Los Angeles, CA 90095-1496 (United States); Curren, J., E-mail: janecurren@yahoo.com [Environmental Science and Engineering Program, University of California, Los Angeles, Los Angeles, CA 90095-1496 (United States); Lau, S.-L., E-mail: simlin@ucla.edu [Department of Civil and Environmental Engineering, University of California, Los Angeles, Los Angeles, CA 90095-1496 (United States); Stenstrom, M.K., E-mail: stenstro@seas.ucla.edu [Department of Civil and Environmental Engineering, University of California, Los Angeles, Los Angeles, CA 90095-1496 (United States); Suffet, I.H., E-mail: msuffet@ucla.edu [Environmental Science and Engineering Program, University of California, Los Angeles, Los Angeles, CA 90095-1496 (United States)

    2011-09-01

    Echo Park Lake is a small lake in Los Angeles, CA listed on the USA Clean Water Act Section 303(d) list of impaired water bodies for elevated levels of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in fish tissue. A lake water and sediment sampling program was completed to support the development of total maximum daily loads (TMDL) to address the lake impairment. The field data indicated quantifiable levels of OCPs and PCBs in the sediments, but lake water data were all below detection levels. The field sediment data obtained may explain the contaminant levels in fish tissue using appropriate sediment-water partitioning coefficients and bioaccumulation factors. A partition-equilibrium fugacity model of the whole lake system was used to interpret the field data and indicated that half of the total mass of the pollutants in the system are in the sediments and the other half is in soil; therefore, soil erosion could be a significant pollutant transport mode into the lake. Modeling also indicated that developing and quantifying the TMDL depends significantly on the analytical detection level for the pollutants in field samples and on the choice of octanol-water partitioning coefficient and bioaccumulation factors for the model. - Research highlights: {yields} Fugacity model using new OCP and PCB field data supports lake TMDL calculations. {yields} OCP and PCB levels in lake sediment were found above levels for impairment. {yields} Relationship between sediment data and available fish tissue data evaluated. {yields} Model provides approximation of contaminant sources and sinks for a lake system. {yields} Model results were sensitive to analytical detection and quantification levels.

  4. Uniaxial-strain mechanical detwinning of CaFe2As2 and BaFe2As2 crystals: Optical and transport study

    International Nuclear Information System (INIS)

    Tanatar, M.A.; Blomberg, E.C.; Kreyssig, A.; Kim, M.G.; Ni, N.; Thaler, A.; Bud'ko, S.L.; Canfield, P.C.; Goldman, A.I.; Mazin, I.I.; Prozorov, R.

    2010-01-01

    The parent compounds of iron-arsenide superconductors, AFe 2 As 2 (A=Ca, Sr, Ba), undergo a tetragonal to orthorhombic structural transition at a temperature T TO in the range 135-205 K depending on the alkaline-earth element. Below T TO the free standing crystals split into equally populated structural domains, which mask intrinsic, in-plane, anisotropic properties of the materials. Here we demonstrate a way of mechanically detwinning CaFe 2 As 2 and BaFe 2 As 2 . The detwinning is nearly complete, as demonstrated by polarized light imaging and synchrotron x-ray measurements, and reversible, with twin pattern restored after strain release. Electrical resistivity measurements in the twinned and detwinned states show that resistivity, ρ, decreases along the orthorhombic a o axis but increases along the orthorhombic b o axis in both compounds. Immediately below T TO the ratio ρ bo /ρ ao = 1.2 and 1.5 for Ca and Ba compounds, respectively. Contrary to CaFe 2 As 2 , BaFe 2 As 2 reveals an anisotropy in the nominally tetragonal phase, suggesting that either fluctuations play a larger role above T TO in BaFe 2 As 2 than in CaFe 2 As 2 or that there is a higher temperature crossover or phase transition.

  5. Progressive Decline in Hippocampal CA1 Volume in Individuals at Ultra-High-Risk for Psychosis Who Do Not Remit: Findings from the Longitudinal Youth at Risk Study.

    Science.gov (United States)

    Ho, New Fei; Holt, Daphne J; Cheung, Mike; Iglesias, Juan Eugenio; Goh, Alex; Wang, Mingyuan; Lim, Joseph Kw; de Souza, Joshua; Poh, Joann S; See, Yuen Mei; Adcock, Alison R; Wood, Stephen J; Chee, Michael Wl; Lee, Jimmy; Zhou, Juan

    2017-05-01

    Most individuals identified as ultra-high-risk (UHR) for psychosis do not develop frank psychosis. They continue to exhibit subthreshold symptoms, or go on to fully remit. Prior work has shown that the volume of CA1, a subfield of the hippocampus, is selectively reduced in the early stages of schizophrenia. Here we aimed to determine whether patterns of volume change of CA1 are different in UHR individuals who do or do not achieve symptomatic remission. Structural MRI scans were acquired at baseline and at 1-2 follow-up time points (at 12-month intervals) from 147 UHR and healthy control subjects. An automated method (based on an ex vivo atlas of ultra-high-resolution hippocampal tissue) was used to delineate the hippocampal subfields. Over time, a greater decline in bilateral CA1 subfield volumes was found in the subgroup of UHR subjects whose subthreshold symptoms persisted (n=40) and also those who developed clinical psychosis (n=12), compared with UHR subjects who remitted (n=41) and healthy controls (n=54). No baseline differences in volumes of the overall hippocampus or its subfields were found among the groups. Moreover, the rate of volume decline of CA1, but not of other hippocampal subfields, in the non-remitters was associated with increasing symptom severity over time. Thus, these findings indicate that there is deterioration of CA1 volume in persistently symptomatic UHR individuals in proportion to symptomatic progression.

  6. SeO2 adsorption on CaO surface: DFT study on the adsorption of a single SeO2 molecule

    Science.gov (United States)

    Fan, Yaming; Zhuo, Yuqun; Lou, Yu; Zhu, Zhenwu; Li, Liangliang

    2017-08-01

    Selenium is a hazardous element in coal. During coal combustion, most of the selenium will convert to SeO2 in the flue gas. Ca-based adsorbents, especially CaO, have been considered as a potential sorbent to adsorb SeO2 due to its low cost. In this paper, the adsorption mechanisms of single SeO2 on CaO surface were investigated by density functional theory (DFT) calculation. Both the physisorption and chemisorption structures were determined. It has been identified that the adsorption of SeO2 on CaO surface is primarily chemisorption, while physisorption takes effects at the initial stage of the process. Under O2 atmosphere, selenate is hard to form. Most of the adsorption products are selenite. Additionally, the electron density maps were obtained to reveal the surface active sites. The partial density of states (PDOS) was calculated for analyzing the electronic structural change of SeO2 and CaO surface during adsorption. The results provide fundamental information of the adsorption process, which could be meaningful for the development of new absorbents.

  7. Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study

    OpenAIRE

    Kokaze, Akatsuki; Ishikawa, Mamoru; Matsunaga, Naomi; Karita, Kanae; Yoshida, Masao; Ohtsu, Tadahiro; Ochiai, Hirotaka; Shirasawa, Takako; Nanri, Hinako; Hoshino, Hiromi; Takashima, Yutaka

    2014-01-01

    Background Mitochondrial DNA 5178 cytosine/adenosine (Mt5178 C/A) polymorphism is associated with longevity in the Japanese. The purpose of this study is to investigate whether Mt5178 C/A polymorphism modifies the effects of habitual smoking or habitual drinking on serum non-high-density lipoprotein (non-HDL) cholesterol levels in middle-aged Japanese men. Methods A total of 394 male subjects (age 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regu...

  8. Store-operated Ca2+ entry is not required for fertilization-induced Ca2+ signaling in mouse eggs.

    Science.gov (United States)

    Bernhardt, Miranda L; Padilla-Banks, Elizabeth; Stein, Paula; Zhang, Yingpei; Williams, Carmen J

    2017-07-01

    Repetitive oscillations in cytoplasmic Ca 2+ due to periodic Ca 2+ release from the endoplasmic reticulum (ER) drive mammalian embryo development following fertilization. Influx of extracellular Ca 2+ to support the refilling of ER stores is required for sustained Ca 2+ oscillations, but the mechanisms underlying this Ca 2+ influx are controversial. Although store-operated Ca 2+ entry (SOCE) is an appealing candidate mechanism, several groups have arrived at contradictory conclusions regarding the importance of SOCE in oocytes and eggs. To definitively address this question, Ca 2+ influx was assessed in oocytes and eggs lacking the major components of SOCE, the ER Ca 2+ sensor STIM proteins, and the plasma membrane Ca 2+ channel ORAI1. We generated oocyte-specific conditional knockout (cKO) mice for Stim1 and Stim2, and also generated Stim1/2 double cKO mice. Females lacking one or both STIM proteins were fertile and their ovulated eggs displayed normal patterns of Ca 2+ oscillations following fertilization. In addition, no impairment was observed in ER Ca 2+ stores or Ca 2+ influx following store depletion. Similar studies were performed on eggs from mice globally lacking ORAI1; no abnormalities were observed. Furthermore, spontaneous Ca 2+ influx was normal in oocytes from Stim1/2 cKO and ORAI1-null mice. Finally, we tested if TRPM7-like channels could support spontaneous Ca 2+ influx, and found that it was largely prevented by NS8593, a TRPM7-specific inhibitor. Fertilization-induced Ca 2+ oscillations were also impaired by NS8593. Combined, these data robustly show that SOCE is not required to support appropriate Ca 2+ signaling in mouse oocytes and eggs, and that TRPM7-like channels may contribute to Ca 2+ influx that was previously attributed to SOCE. Published by Elsevier Ltd.

  9. MicroRNA-145 suppresses ROS-induced Ca{sup 2+} overload of cardiomyocytes by targeting CaMKIIδ

    Energy Technology Data Exchange (ETDEWEB)

    Cha, Min-Ji [Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Jang, Jin-Kyung [College of Pharmacy, Sookmyung Women’s University, 52 HyoChangWon-Gil, Yongsan-ku, Seoul 140-742 (Korea, Republic of); Ham, Onju; Song, Byeong-Wook; Lee, Se-Yeon [Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Lee, Chang Yeon; Park, Jun-Hee [Department of Integrated Omics for Biomedical Sciences, Graduate School, Yonsei University, 50 Yonsei-ro, Seodamun-gu, Seoul 120-759 (Korea, Republic of); Lee, Jiyun; Seo, Hyang-Hee [Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Choi, Eunhyun [Severance Integrative Research Institute for Cerebral and Cardiovascular Disease, Yonsei University Health System, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Jeon, Woo-min [Department of Animal Resource, Sahmyook University, Seoul 139-742 (Korea, Republic of); Hwang, Hye Jin [Cardiovascular Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodamun-gu, Seoul 120-752 (Korea, Republic of); Shin, Hyun-Taek [College of Pharmacy, Sookmyung Women’s University, 52 HyoChangWon-Gil, Yongsan-ku, Seoul 140-742 (Korea, Republic of); and others

    2013-06-14

    Highlights: •CaMKIIδ mediates H{sub 2}O{sub 2}-induced Ca{sup 2+} overload in cardiomyocytes. •miR-145 can inhibit Ca{sup 2+} overload. •A luciferase assay confirms that miR-145 functions as a CaMKIIδ-targeting miRNA. •Overexpression of miR-145 regulates CaMKIIδ-related genes and ameliorates apoptosis. -- Abstract: A change in intracellular free calcium (Ca{sup 2+}) is a common signaling mechanism of reperfusion-induced cardiomyocyte death. Calcium/calmodulin dependent protein kinase II (CaMKII) is a critical regulator of Ca{sup 2+} signaling and mediates signaling pathways responsible for functions in the heart including hypertrophy, apoptosis, arrhythmia, and heart disease. MicroRNAs (miRNA) are involved in the regulation of cell response, including survival, proliferation, apoptosis, and development. However, the roles of miRNAs in Ca{sup 2+}-mediated apoptosis of cardiomyocytes are uncertain. Here, we determined the potential role of miRNA in the regulation of CaMKII dependent apoptosis and explored its underlying mechanism. To determine the potential roles of miRNAs in H{sub 2}O{sub 2}-mediated Ca{sup 2+} overload, we selected and tested 6 putative miRNAs that targeted CaMKIIδ, and showed that miR-145 represses CaMKIIδ protein expression and Ca{sup 2+} overload. We confirmed CaMKIIδ as a direct downstream target of miR-145. Furthermore, miR-145 regulates Ca{sup 2+}-related signals and ameliorates apoptosis. This study demonstrates that miR-145 regulates reactive oxygen species (ROS)-induced Ca{sup 2+} overload in cardiomyocytes. Thus, miR-145 affects ROS-mediated gene regulation and cellular injury responses.

  10. Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas

    DEFF Research Database (Denmark)

    Gustavsson, Natalia; Wei, Shun-Hui; Hoang, Dong Nhut

    2009-01-01

    Hormones such as glucagon are secreted by Ca(2+)-induced exocytosis of large dense-core vesicles, but the mechanisms involved have only been partially elucidated. Studies of pancreatic beta-cells secreting insulin revealed that synaptotagmin-7 alone is not sufficient to mediate Ca(2+)-dependent...... insulin granule exocytosis, and studies of chromaffin cells secreting neuropeptides and catecholamines showed that synaptotagmin-1 and -7 collaborate as Ca(2+) sensors for exocytosis, and that both are equally involved. As no other peptide secretion was analysed, it remains unclear whether synaptotagmins...... generally act as Ca(2+) sensors in large dense-core vesicle exocytosis in endocrine cells, and if so, whether synaptotagmin-7 always functions with a partner in that role. In particular, far less is known about the mechanisms underlying Ca(2+)-triggered glucagon release from alpha-cells than insulin...

  11. Sex differences in accuracy and precision when judging time to arrival: data from two Internet studies.

    Science.gov (United States)

    Sanders, Geoff; Sinclair, Kamila

    2011-12-01

    We report two Internet studies that investigated sex differences in the accuracy and precision of judging time to arrival. We used accuracy to mean the ability to match the actual time to arrival and precision to mean the consistency with which each participant made their judgments. Our task was presented as a computer game in which a toy UFO moved obliquely towards the participant through a virtual three-dimensional space on route to a docking station. The UFO disappeared before docking and participants pressed their space bar at the precise moment they thought the UFO would have docked. Study 1 showed it was possible to conduct quantitative studies of spatiotemporal judgments in virtual reality via the Internet and confirmed reports that men are more accurate because women underestimate, but found no difference in precision measured as intra-participant variation. Study 2 repeated Study 1 with five additional presentations of one condition to provide a better measure of precision. Again, men were more accurate than women but there were no sex differences in precision. However, within the coincidence-anticipation timing (CAT) literature, of those studies that report sex differences, a majority found that males are both more accurate and more precise than females. Noting that many CAT studies report no sex differences, we discuss appropriate interpretations of such null findings. While acknowledging that CAT performance may be influenced by experience we suggest that the sex difference may have originated among our ancestors with the evolutionary selection of men for hunting and women for gathering.

  12. Fundamental study on in situ capture of CO{sub 2} with Ca-based sorbents during lime-enhanced steam gasification of coal

    Energy Technology Data Exchange (ETDEWEB)

    Koji Kuramoto; Sayaka Shibano; Atsuko Morita; Koichi Matsuoka; Yoshizo Suzuki; Hiroyuki Hatano; Lin Shi-Ying; Michiaki Harada; Takayuki Takarada [National Institute of AIST, Ibaraki (Japan)

    2005-07-01

    New hydrogen production process, HyPr-RING, has been proposed. This is a novel process where a high-pressure steam is decomposed thermochemically with coal under the presence of Ca-based CO{sub 2} sorbents in a single reactor, producing hydrogen in high yield with little release of CO{sub 2}. In an effort to develop this novel hydrogen production process, fundamental CO{sub 2} sorption characteristics of Ca-based sorbents during repetitive carbonation-calcination reactions under different pressures were investigated using a laboratory-scale horizontal-tube reactor. The results revealed that Ca-based sorbents were significantly deactivated by high temperature calcination treatment. An intermediate hydration treatment for the calcined sorbents (CaO) was found to enhance the reactivity and durability of the sorbents for multicycle CO{sub 2} sorption. Deactivation of Ca-based sorbents by coal-derived minerals during multicycle CO{sub 2} sorption reactions at elevated temperature and pressure was also investigated using a laboratory-scale horizontal-tube reactor. The sorbents tended to undergo a solid-solid reaction with coal-derived ash components such as silicon (Si) and aluminium (Al) during multicycle CO{sub 2} sorption with an intermediate hydration stage. This result suggests that steam enhanced the solid-solid reaction between the minerals and the sorbents at elevated temperature ({gt} 873 K) and pressure (6.0 MPa) and that the interaction should be avoided by selecting proper reaction conditions for efficient utilization of the Ca-based sorbents. 11 refs., 6 figs.

  13. X-ray photo-emission studies of Cu1-xTlxBa2Ca3Cu4O12-y superconductor thin films

    International Nuclear Information System (INIS)

    Khan, Nawazish A.; Mumtaz, M.; Ahadian, M.M.; Iraji-zad, Azam

    2006-01-01

    X-ray photo-emission spectroscopy (XPS) studies of Cu 1-x Tl x Ba 2 Ca 3 Cu 4 O 12-y superconductor thin films have been carried out for understanding the mechanism of superconductivity and to find out the reasons for the increase of zero resistivity critical temperature T c (R = 0) with post-annealing in a nitrogen atmosphere. It is observed from these studies that reduction of charge state of thallium is a source of doping of carriers to the CuO 2 planes. The reduced charge state of thallium (i.e. Tl 1+ ) promotes lower oxygen concentration in the charge reservoir layer, which possibly results in movement of electrons to the conducting CuO 2 planes. The higher density of electrons in the CuO 2 planes optimizes the hole concentration 'n p ' in these planes. The reduced charge state of thallium in the Cu 1-x Tl x Ba 2 O 4-δ charge reservoir layer is also supported by a shift of the Ba 3d 5/2 and Ba 3d 3/2 XPS lines to lower binding energies with post-annealing in nitrogen atmosphere. Moreover, the movement of the valance band spectrum to lower binding energies suggested that the electronic density of states changes in the valance band with the post-annealing in nitrogen, which possibly becomes a source of doping of carriers to the CuO 2 planes. The increased doping of electrons to the CuO 2 planes optimizes the Fermi-vector K F and Fermi-velocity V F of the carriers and increases the T c (R = 0) of final compound

  14. CA 125 in ovarian cancer

    NARCIS (Netherlands)

    van der Burg, M. E.; Lammes, F. B.; Verweij, J.

    1992-01-01

    The serum tumour marker CA 125 is useful in the management of ovarian cancer, although it has its limitations. Approximately 85% of the ovarian cancer patients have an increased serum CA 125 at the start of treatment. There is a good correlation between the course of CA 125 and the clinical response

  15. Tumor markers CA19-9, CA242 and CEA in the diagnosis of pancreatic cancer: a meta-analysis.

    Science.gov (United States)

    Zhang, Yimin; Yang, Jun; Li, Hongjuan; Wu, Yihua; Zhang, Honghe; Chen, Wenhu

    2015-01-01

    Pancreatic cancer has the worst prognosis and early detection is crucial for improving patient prognosis. Therefore, we performed a meta-analysis to evaluate and compare the sensitivity and specificity of single test of CA19-9, CA242, and CEA, as well as combination test in pancreatic cancer detection. We searched PubMed, Embase, Medline, and Wanfang databases for studies that evaluated the diagnostic validity of CA19-9, CA242, and CEA between January 1990 and September 2014. Data were analyzed by Meta-Disc and STATA software. A total of 21 studies including 3497 participants, which fulfilled the inclusion criteria were considered for analysis. The pooled sensitivities for CA19-9, CA242, and CEA were 75.4 (95% CI: 73.4-77.4), 67.8 (95% CI: 65.5-70), and 39.5 (95% CI: 37.3-41.7), respectively. The pooled specificities of CA19-9, CA242, and CEA were 77.6 (95% CI: 75.4-79.7), 83 (95% CI: 81-85), and 81.3 (95% CI: 79.3-83.2), respectively. Parallel combination of CA19-9+CA242 has a higher sensitivity (89, 95% CI: 80-95) without impairing the specificity (75, 95% CI: 67-82). Our meta-analysis showed that CA242 and CA19-9 have better performance in the diagnosis of pancreatic cancer than CEA. Furthermore, parallel combination test of CA19-9+CA242 could be of better diagnostic value than individual CA242 or CA19-9 test.

  16. Integrated Mechanisms of CaMKII-dependent ventricular remodeling

    Directory of Open Access Journals (Sweden)

    Michael M Kreusser

    2014-03-01

    Full Text Available CaMKII has been shown to be activated during different cardiac pathological processes, and CaMKII-dependent mechanisms contribute to pathological cardiac remodeling, cardiac arrhythmias and contractile dysfunction during heart failure. Activation of CaMKII during cardiac stress results in a broad number of biological effects such as, on the one hand, acute effects due to phosphorylation of distinct cellular proteins as ion channels and calcium handling proteins and, on the other hand, integrative mechanisms by changing gene expression. This review focuses on transcriptional and epigenetic effects of CaMKII activation during chronic cardiac remodeling. Multiple mechanisms have been described how CaMKII mediates changes in cardiac gene expression. CaMKII has been shown to directly phosphorylate components of the cardiac gene regulation machinery. CaMKII phosphorylates several transcription factors such as CREB that induces the activation of specific gene programs. CaMKII activates transcriptional regulators also indirectly by phosphorylating histone deacetylases, especially HDAC4, which in turn inhibits transcription factors that drive cardiac hypertrophy, fibrosis and dysfunction. Recent studies demonstrate that CaMKII also phosphorylate directly histones, which may contribute to changes in gene expression. These findings of CaMKII-dependent gene regulation during cardiac remodeling processes suggest novel strategies for CaMKII-dependent transcriptional or epigenetic therapies to control cardiac gene expression and function. Manipulation of CaMKII-dependent signaling pathways in the settings of pathological cardiac growth, remodeling, and heart failure represents an auspicious therapeutic approach.

  17. Use of a Ca-Citrate-Phosphate Solution to Form Hydroxyapatite for Uranium Stabilization of Old Rifle Sediments: Laboratory Proof of Principle Studies

    Energy Technology Data Exchange (ETDEWEB)

    Szescody, James E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Moore, Robert C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rigali, Mark J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Vermeul, Vincent R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Luellen, Jon [AECOM, Denver, CO (United States)

    2016-03-01

    The Old Rifle Site is a former vanadium and uranium ore-processing facility located adjacent to the Colorado River and approximately 0.3 miles east of the city of Rifle, CO. The former processing facilities have been removed and the site uranium mill tailings are interned at a disposal cell north of the city of Rifle. However, some low level remnant uranium contamination still exists at the Old Rifle site. In 2002, the United States Nuclear Regulatory Commission (US NRC) concurred with United States Department of Energy (US DOE) on a groundwater compliance strategy of natural flushing with institutional controls to decrease contaminant concentrations in the aquifer. In addition to active monitoring of contaminant concentrations, the site is also used for DOE Legacy Management (LM) and other DOE-funded small-scale field tests of remediation technologies. The purpose of this laboratory scale study was to evaluate the effectiveness of a hydroxyapatite (Ca10(PO4)6(OH)2) permeable reactive barrier and source area treatment in Old Rifle sediments. Phosphate treatment impact was evaluated by comparing uranium leaching and surface phase changes in untreated to PO4-treated sediments. The impact of the amount of phosphate precipitation in the sediment on uranium mobility was evaluated with three different phosphate loadings. A range of flow velocity and uranium concentration conditions (i.e., uranium flux through the phosphate-treated sediment) was also evaluated to quantify the uranium uptake mass and rate by the phosphate precipitate.

  18. Laser cooling of CaBr molecules and production of ultracold Br atoms: A theoretical study including spin-orbit coupling.

    Science.gov (United States)

    Fu, Mingkai; Ma, Haitao; Cao, Jianwei; Bian, Wensheng

    2017-04-07

    Owing to the exciting potential applications of ultracold atoms and molecules in many fields, developing new cooling schemes has attracted great interests in recent years. Here, we investigate laser cooling of CaBr molecules and design a photonic scheme for the production of ultracold Br atoms using the highly accurate ab initio and dynamical methods. We find that the AΠ1/22(ν ' =0)→X 2 Σ 1/2 + (ν=0) transition for CaBr features a large vibrational branching ratio, a significant photon-scattering rate, and no intermediate electronic-state interference, indicating that the ultracold CaBr could be produced through a three-laser cooling scheme. Moreover, an efficient four-pulse excitation scheme from the ground rovibrational level of the cooled CaBr molecules is proposed to yield ultracold Br atoms, in which a few spin-orbit excited states are utilized as the intermediate states. The importance of the spin-orbit coupling is underscored in this work.

  19. [11C]A-69024: A potent and selective non-benzazepine radiotracer for in vivo studies of dopamine D1 receptors

    International Nuclear Information System (INIS)

    Kassiou, Michael; Scheffel, Ursula; Ravert, Hayden T.; Mathews, William B.; Musachio, John L.; Lambrecht, Richard M.; Dannals, Robert F.

    1995-01-01

    [ 11 C]A-69024, (±)-1-(2-bromo-4,5-dimethoxybenzyl)-7-hydroxy-6-methoxy-2- [ 11 C]methyl-1,2,3,4-tetrahydroisoquinoline, is a specific and selective dopamine D1 radiotracer. The in vivo biodistribution of this novel radioligand in mice showed a high uptake in the striatum (6.7% ID/g) at 5 min, followed by clearance with a half-life of 16.1 min. As a measure of specificity, the striatal/cerebellar ratio reached a maximum of 7.4 at 30 min post-injection. Radioactivity in the striatum was reduced to the level of the cerebellum by pre-administration of the D1 antagonist SCH 23390 (1 mg/kg). Pretreatment of mice with spiperone (D2), 7-hydroxydipropylaminotetralin (7-OH-DPAT) (D3), clozapine (D4), ketanserin (5-HT2/5-HT2C), mazindol (monoamine reuptake), prazosin (α 1 ), and haloperidol (D2/σ) had no inhibitory effect on [ 11 C]A-69024 uptake in the striatum. The dextrotatory enantiomer of the dopamine antagonist butaclamol inhibited striatal uptake, while the less active isomer (-)-butaclamol did not. [ 11 C]A-69024 binding was inhibited by unlabeled A-69024 in a dose dependent manner (ED 50 = 0.3 mg/kg) in the striatum while no change occurred in the cerebellum. [ 11 C]A-69024 warrants further investigation as a PET ligand for examination of central dopamine D1 receptors in humans.

  20. Basic study of Europium doped LiCaAlF.sub.6./sub. scintillator and its capability for thermal neutron imaging application

    Czech Academy of Sciences Publication Activity Database

    Yanagida, T.; Kawaguchi, N.; Fujimoto, Y.; Fukuda, K.; Yokota, Y.; Yamazaki, A.; Watanabe, K.; Pejchal, Jan; Uritani, A.; Iguchi, T.; Yoshikawa, A.

    2011-01-01

    Roč. 33, č. 8 (2011), s. 1243-1247 ISSN 0925- 3467 Institutional research plan: CEZ:AV0Z10100521 Keywords : LiCaAlF 6 * single crystal * scintillation detector * Eu 2+ * neutron scintillator Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.023, year: 2011

  1. Quantum chemical study of the nature of the ground state and the pressure-induced spin transition in CaFeO3

    NARCIS (Netherlands)

    Sadoc, Aymeric; de Graaf, Coen; Broer, Ria

    Ab initio calculations have been performed to clarify the character of the electronic ground state of the high-temperature phase of CaFeO3 at different external pressures. The analysis of the correlated N-electron wave function of properly embedded FeO6 clusters in terms of optimal atomic orbitals

  2. Preoperative CEA and CA 19-9 are prognostic markers for survival after curative resection for ductal adenocarcinoma of the pancreas - a retrospective tumor marker prognostic study.

    Science.gov (United States)

    Distler, Marius; Pilarsky, Eva; Kersting, Stephan; Grützmann, Robert

    2013-01-01

    The prognosis for patients with ductal adenocarcinoma of the pancreas (PDAC) remains poor even after curative resection. Carbohydrate antigen 19-9 (CA 19-9) and the carcinoembryonic antigen (CEA) are the most widely used serum-based tumor markers for the diagnosis and follow up of pancreatic cancer. In our analysis we aim to assess the prognostic value of a combination of both tumor markers in patients with pancreatic ductal adenocarcinoma (PDAC). Between 01/1995 and 08/2012 we performed a total of 264 pancreatic resections due to PDAC. Patients were stratified into 3 groups in regard to their preoperative tumor marker levels. Survival was compared between the groups using Kaplan Meier analysis and log rank test. Univariate subgroup analysis and multivariate analysis were performed. For 259 cases complete follow up could be obtained. In patients with low preoperative CEA and CA 19-9 levels (group 1 n = 91) the mean survival was 33.3 month (CI 95% 25.1-41.5). If one of the analyzed tumor markers (CEA/CA19-9) was preoperatively elevated above the cut-off level (group 2 n = 106) mean survival was 28.5 month (CI 95% 22.1-35.1). 62 patients showed preoperative elevation of both, CEA and CA 19-9 (group 3); mean survival in this group was 23.9 month (CI 95% 13.9-33.9), p > 0.01. Multivariate analysis confirmed preoperative CEA/CA 19-9 level as independent prognostic factor (HR 1.299). Preoperative CEA and CA 19-9 levels correlate with patient prognosis after curative pancreatic resection due to PDAC. This is especially true for the most frequently pT 3/4 stages of PDAC. Even if CEA and CA 19-9 might not be appropriate for screening, its serum levels should therefore be determined prior to operation and taken into account when resectability or operability is doubtful. Copyright © 2013 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

  3. [Study on the Relationship Between Normalization of Tumor Microvessels and CA9 for Rh-Endostatin to Inhibit Lewis Lung Cancer].

    Science.gov (United States)

    He, Lang; Sun, Yong-Hong; Liu, Kang; Xu, Xing-Xing; Yang, Mi; Wu, Xun; Jiang, Li

    2017-05-01

    To explore the relationship between normalization of tumor microvessels and CA9 for rh-Endostatin to inhibit Lewis lung cancer (LLC) and the expression level of CA9 in LLC. Lewis cells of logarithmic growth phase were collected and made into 1×10 6 mL -1 cell suspensions were prepared. The transplanted tumor model of LLC was established on C57/BL6 mice by injected 0.2 mL cell suspensions/mice into 40 C57/BL6 mice. 40 LLC mice were randomly divided into control group and rh-ES group (20 mice per group). Control group experienced treatment of intraperitoneal injection (ip) for 0.2 mL NS/d, while rh-ES group was treated for 5 mg rh-ES/(kg·d) from the first to the ninth day. The samples of 5 mice were obtained from day 2, day 4, day 6 and day 9 after treatment in control group or rh-ES group, respectively. CA9 was tested by IHC in LLC and paracancerous tissues and estimated by RT-PCR and ELISA in the each time point of both rh-ES group and control group,respectively. The transplanted tumor model of LLC on C57/BL6 mice was established successfully. The expression of CA9 decreased on day 4 and day 6 in rh-ES group estimated by RT-PCR and ELISA, which indicated some great significance when compared with day 2, day 9 in rh-ES group and day 4, day 6 in control group ( P Rh-ES could have positive effect on LLC model of C57/BL6 mice, in day 4-6 (a brief normalized time course) decreased the expression of CA9 and reversed the tumor hypoxia.

  4. Predictors of pretreatment CA125 at ovarian cancer diagnosis

    DEFF Research Database (Denmark)

    Babic, Ana; Cramer, Daniel W; Kelemen, Linda E

    2017-01-01

    in CA125 between studies and linear regression to estimate the association between epidemiologic factors and tumor characteristics and pretreatment CA125 levels. RESULTS: In age-adjusted models, older age, history of pregnancy, history of tubal ligation, family history of breast cancer, and family...... history of ovarian cancer were associated with higher CA125 levels while endometriosis was associated with lower CA125 levels. After adjusting for tumor-related characteristics (stage, histology, grade), body mass index (BMI) higher than 30 kg/m2was associated with 10% (95% CI 2, 19%) higher CA125 levels...

  5. The other side of cardiac Ca2+ signaling: transcriptional control

    Directory of Open Access Journals (Sweden)

    Alejandro eDomínguez-Rodríquez

    2012-11-01

    Full Text Available Ca2+ is probably the most versatile signal transduction element used by all cell types. In the heart, it is essential to activate cellular contraction in each heartbeat. Nevertheless Ca2+ is not only a key element in excitation-contraction coupling (EC coupling, but it is also a pivotal second messenger in cardiac signal transduction, being able to control processes such as excitability, metabolism, and transcriptional regulation. Regarding the latter, Ca2+ activates Ca2+-dependent transcription factors by a process called excitation-transcription coupling (ET coupling. ET coupling is an integrated process by which the common signaling pathways that regulate EC coupling activate transcription factors. Although ET coupling has been extensively studied in neurons and other cell types, less is known in cardiac muscle. Some hints have been found in studies on the development of cardiac hypertrophy, where two Ca2+-dependent enzymes are key actors: Ca2+/Calmodulin kinase II (CaMKII and phosphatase calcineurin, both of which are activated by the complex Ca2+/ /Calmodulin. The question now is how ET coupling occurs in cardiomyocytes, where intracellular Ca2+ is continuously oscillating. In this focused review, we will draw attention to location of Ca2+ signaling: intranuclear ([Ca2+]n or cytoplasmic ([Ca2+]c, and the specific ionic channels involved in the activation of cardiac ET coupling. Specifically, we will highlight the role of the 1,4,5 inositol triphosphate receptors (IP3Rs in the elevation of [Ca2+]n levels, which are important to locally activate CaMKII, and the role of transient receptor potential channels canonical (TRPCs in [Ca2+]c, needed to activate calcineurin.

  6. Preliminary results on the use of Ca 15-3 in malignant ovarian pathology