WorldWideScience

Sample records for c8 health project

  1. Tenuous dose-response correlations for common disease states: case study of cholesterol and perfluorooctanoate/sulfonate (PFOA/PFOS) in the C8 Health Project.

    Science.gov (United States)

    Kerger, Brent D; Copeland, Teri L; DeCaprio, Anthony P

    2011-10-01

    Persistent organic chemicals, such as perfluorooctanoic acid (PFOA), perfluorooctanesulfonate (PFOS), dioxins, and polychlorinated biphenyls, pose investigative challenges because they are found in virtually everyone (there is no unexposed control group). To overcome this problem, outcome data in some studies are sorted by chemical dose level and findings in low-end dose groups are compared to sequential higher dose groups. An example is the C8 Health Project that evaluated serum PFOA/PFOS (C8) and total cholesterol among 46,294 West Virginia residents who lived, worked, or went to school for at least 1 year in a C8 contaminated drinking-water district and were over age 18 in 2005-2006. The risk for high total cholesterol (>240 mg/dL) measured via odds ratios (ORs) in logistic regression models showed sequential OR increases with PFOA quartile, in comparison to the lowest quartile (OR = 1.00), that were each significantly elevated (OR = 1.21, 1.33, and 1.40, respectively), but age, sex, and body mass index were stronger correlates. Importantly, the magnitude of cholesterol increase was small (12 mg/dL from lowest to highest exposure deciles) and comparison to similar statistics for the general U.S. population showed the C8 cohort had lower rates of high cholesterol. This suggests that inadvertent selection bias may have affected the lowest exposure quartile (control group), making tenuous the dose-response relationship between PFOA/PFOS and risk of high cholesterol. This case illustrates the substantial difficulties in assigning toxicological importance to statistical comparisons for common disease states that utilize subgroups with low exposures as an effective control group. PMID:21770727

  2. Perfluorocarbons and Gilbert syndrome (phenotype) in the C8 Health Study Population

    Energy Technology Data Exchange (ETDEWEB)

    Fan, Hongmin [Cancer Center, School of Public Health, West Virginia University, Morgantown, WV 265050-9190 (United States); Department of Epidemiology and Statistics, School of Public Health, Hebei United University, Hebei 063000 (China); Ducatman, Alan [Department of Occupational and Environmental Health, School of Public Health, West Virginia University (United States); Department of Medicine, School of Medicine, West Virginia University (United States); Clinical Translational Science Institute, West Virginia University (United States); Zhang, Jianjun [Department of Biostatistics, School Public Health, West Virginia University (United States)

    2014-11-15

    Background: Gilbert syndrome (GS) is an inherited defect of bilirubin conjugation, most commonly caused by a gene mutation for the enzyme UGT1A. GS is known to affect the metabolism and excretion of drugs and xenobiotics. Perfluorocarbon compounds (PFCs) are bio-persistent environmental contaminants that affect metabolic regulation. In this study, we examined the associations of GS phenotype and serum PFCs in the C8 Health Study Population. Materials and methods: Using 2005–2006 data from a large PFC-exposure population survey, we compared serum PFCs concentrations between GS and non GS clinical phenotypes, in a cross sectional design, adjusting for standard risk factors, including age, BMI, smoking status, socioeconomic status and gender. Results: Among 10 PFC compounds considered, only perfluorohexanoic acid (PFHxA) was seen at a significantly higher concentration in GS men and women. Conclusion: PFHxA exposure may be associated with GS. Our findings do not support increased exposure in GS for other PFCs. - Highlights: • Most serum PFCs are not associated with clinically evident Gilbert syndrome. • However, serum perfluorohexanoic acid is positively associated. • The investigation addresses the clinical presentation, not the genetic mutation.

  3. Perfluorocarbons and Gilbert syndrome (phenotype) in the C8 Health Study Population

    International Nuclear Information System (INIS)

    Background: Gilbert syndrome (GS) is an inherited defect of bilirubin conjugation, most commonly caused by a gene mutation for the enzyme UGT1A. GS is known to affect the metabolism and excretion of drugs and xenobiotics. Perfluorocarbon compounds (PFCs) are bio-persistent environmental contaminants that affect metabolic regulation. In this study, we examined the associations of GS phenotype and serum PFCs in the C8 Health Study Population. Materials and methods: Using 2005–2006 data from a large PFC-exposure population survey, we compared serum PFCs concentrations between GS and non GS clinical phenotypes, in a cross sectional design, adjusting for standard risk factors, including age, BMI, smoking status, socioeconomic status and gender. Results: Among 10 PFC compounds considered, only perfluorohexanoic acid (PFHxA) was seen at a significantly higher concentration in GS men and women. Conclusion: PFHxA exposure may be associated with GS. Our findings do not support increased exposure in GS for other PFCs. - Highlights: • Most serum PFCs are not associated with clinically evident Gilbert syndrome. • However, serum perfluorohexanoic acid is positively associated. • The investigation addresses the clinical presentation, not the genetic mutation

  4. Health System Measurement Project

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Health System Measurement Project tracks government data on critical U.S. health system indicators. The website presents national trend data as well as detailed...

  5. Lunar Health Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — During the Phase II Lunar Health Monitor program, Orbital Research will develop a second generation wearable sensor suite for astronaut physiologic monitoring. The...

  6. Killing of Staphylococcus aureus by C-8-Methoxy Fluoroquinolones

    OpenAIRE

    Zhao, Xilin; Wang, Jian-Ying; Xu, Chen; Dong, Yuzhi; Zhou, Jianfeng; Domagala, John; Drlica, Karl

    1998-01-01

    C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8-ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encourage refinement of C-8-methoxy fluoroquinolones to kill staphylococci.

  7. Integrated Structural Health Management Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Cornerstone Research Group Inc. (CRG) proposes to advance the state of the art in composite health management through refinement of an existing technology developed...

  8. Wearable Health Monitoring Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of this proposal is to demonstrate the feasibility of producing a wearable health monitoring system for the human body that is functional,...

  9. UMTRA Project: Environment, Safety, and Health Plan

    Energy Technology Data Exchange (ETDEWEB)

    1995-02-01

    The US Department of Energy has prepared this UMTRA Project Environment, Safety, and Health (ES and H) Plan to establish the policy, implementing requirements, and guidance for the UMTRA Project. The requirements and guidance identified in this plan are designed to provide technical direction to UMTRA Project contractors to assist in the development and implementation of their ES and H plans and programs for UMTRA Project work activities. Specific requirements set forth in this UMTRA Project ES and H Plan are intended to provide uniformity to the UMTRA Project`s ES and H programs for processing sites, disposal sites, and vicinity properties. In all cases, this UMTRA Project ES and H Plan is intended to be consistent with applicable standards and regulations and to provide guidance that is generic in nature and will allow for contractors` evaluation of site or contract-specific ES and H conditions. This plan specifies the basic ES and H requirements applicable to UMTRA Project ES and H programs and delineates responsibilities for carrying out this plan. DOE and contractor ES and H personnel are expected to exercise professional judgment and apply a graded approach when interpreting these guidelines, based on the risk of operations.

  10. UMTRA Project: Environment, Safety, and Health Plan

    International Nuclear Information System (INIS)

    The US Department of Energy has prepared this UMTRA Project Environment, Safety, and Health (ES and H) Plan to establish the policy, implementing requirements, and guidance for the UMTRA Project. The requirements and guidance identified in this plan are designed to provide technical direction to UMTRA Project contractors to assist in the development and implementation of their ES and H plans and programs for UMTRA Project work activities. Specific requirements set forth in this UMTRA Project ES and H Plan are intended to provide uniformity to the UMTRA Project's ES and H programs for processing sites, disposal sites, and vicinity properties. In all cases, this UMTRA Project ES and H Plan is intended to be consistent with applicable standards and regulations and to provide guidance that is generic in nature and will allow for contractors' evaluation of site or contract-specific ES and H conditions. This plan specifies the basic ES and H requirements applicable to UMTRA Project ES and H programs and delineates responsibilities for carrying out this plan. DOE and contractor ES and H personnel are expected to exercise professional judgment and apply a graded approach when interpreting these guidelines, based on the risk of operations

  11. Project Health: Evaluation of a Project-Based Health Education Program

    Science.gov (United States)

    Zusevics, Kaija L.; Lemke, Melissa A.; Harley, Amy E.; Florsheim, Paul

    2013-01-01

    Purpose: Milwaukee has very high rates of risky sexual behavior and low rates of academic achievement among adolescents. Milwaukee school representatives partnered with researchers to create and implement an innovative project-based learning (PBL) high school health curriculum to engage students in school. This health education program, Project…

  12. The health terminology project glossaries` structure

    Directory of Open Access Journals (Sweden)

    Sátia Marini

    2014-04-01

    Full Text Available Current paper was motivated by a Master´s degree in Translation Studies on one of the glossaries of the Health Terminology Project (PTS of the Ministry of Health (MS inBrazil, by which the products developed by the project were analyzed. The authors would like to forward their experience earned from the development of these instruments and from the evolution of the glossary´s layout and structure. Although within the same institution, each instrument is made suitable to the specific purpose of each area and the terminology project accumulates experience by the constant improvement of previously developed glossaries (adding new terms; providing the equivalent word in other languages for terms already defined and by the establishment of new ones. The evolution of the structure of the glossaries was qualitatively analyzed; remarks on the types of cross references were made; a quantitative survey of their main features was undertaken. Finally, the importance of this type of work should be underscored either within the government, or in the academy or in private companies, for the sharing of intellectual knowledge.

  13. A study of project management knowledge and sustainable outcomes in Thailand’s reproductive health projects

    OpenAIRE

    Jantanee Dumrak; Bassam Barroudi; Stephen Pullen

    2015-01-01

    In Thailand, numerous reproductive health projects funded by both national and international agencies have been established in an attempt to mitigate reproductive health problems. Solving problems on reproductive health projects that only have temporary funding requires effective project management that hopefully leads to better long-term desired outcomes. This paper identifies the association between collaborative reproductive health (CRH) project management and sustainable outcomes. The Gui...

  14. Meeting minority health needs through special MCH projects.

    OpenAIRE

    Hutchins, V; Walch, C

    1989-01-01

    The maternal and child health programs of the Public Health Service have always been directed to minority populations; however, the recent surges of immigrants from Asian and Central American countries have caused the agency to appraise its efforts to meet the special health needs of these people. Through grants for special projects of regional and national significance (SPRANS), the Office of Maternal and Child Health is funding projects to break down language, culture, and access barriers t...

  15. The Pacific Island Health Care Project

    Directory of Open Access Journals (Sweden)

    Donald Ames Person

    2014-10-01

    Full Text Available Introduction/BackgroundUS Associated/Affiliated Pacific Islands (USAPI include 3 Freely Associated States: Marshall Islands, Federated States of Micronesia, Palau and 3 Territories: American Samoa, Guam, and Commonwealth of the Northern Mariana Islands. ObjectiveThe Pacific Island Health Care Project (PIHCP provides humanitarian medical referral/consultation/care to >500,000 indigenous people of these remote islands. Methods In the mid-1990s, we developed a simple store-and-forward program to link the USAPI with Tripler Army Medical Center (TAMC. This application allowed image attachment to email consultations. ResultsMore than 8000 Pacific Islanders have benefited from the program. 3000 Pacific Islanders prior to telemedicine (1990-1997 and since store-and-forward telemedicine (1997-present, the PIHCP has helped an additional 5000. Records post dynamically and are stored in an archival database. Conclusion The PIHCP is the longest running telemedicine program in the world delivering humanitarian medical care. It has bridged the Developing World of the remote Pacific islands with advanced medical and surgical care available at a major US military teaching hospital.(The opinions expressed here are those of the author and not that of the Army, Department of Defense, or the US Government.

  16. Needs Assessment in Health Research Projects: A New Approach to Project Management in Iran

    Directory of Open Access Journals (Sweden)

    Niloofar Peykari

    2013-02-01

    Full Text Available Background: The science and technology health plan has defined the outline of health research to the national vision of Iran by 2025. The aim of this study was to focus on the process of needs assessment of health research projects also health research priority setting in Iran.Methods: The project management life cycle has four phases: Initiation, Planning, Execution and Closure. Based on abovementioned points we conducted the study.Results: Focusing on the needs assessment led to systematic implementation of needs assessment of health project in all of the medical sciences universities. Parallel with this achieved strategies health research priority setting was followed through specific process from empowerment to implementation.Conclusion: We should adopt with more systematic progressive methods of health project managements for both our national convenience as well as our international health research programs.

  17. Studies on CYP2C8-mediated drug interactions

    OpenAIRE

    Tornio, Aleksi

    2008-01-01

    Useiden lÀÀkkeiden yhtÀaikainen kÀyttö on nykyÀÀn hyvin yleistÀ, mikÀ lisÀÀ lÀÀkeaineiden haitallisten yhteisvaikutusten riskiÀ. LÀÀkeaineiden poistumisessa elimistöstÀ ovat tÀrkeÀssÀ osassa niitÀ hajottavat (metaboloivat) maksan sytokromi P450 (CYP) entsyymit. Vasta aivan viime vuosina on havaittu, ettÀ CYP2C8-entsyymillÀ voi olla tÀrkeÀ merkitys mm. lÀÀkeaineyhteisvaikutuksissa. ErÀÀt lÀÀkeaineet voivat estÀÀ (inhiboida) CYP2C8-entsyymin kautta tapahtuvaa m...

  18. A study of project management knowledge and sustainable outcomes in Thailand’s reproductive health projects

    Directory of Open Access Journals (Sweden)

    Jantanee Dumrak

    2015-05-01

    Full Text Available In Thailand, numerous reproductive health projects funded by both national and international agencies have been established in an attempt to mitigate reproductive health problems. Solving problems on reproductive health projects that only have temporary funding requires effective project management that hopefully leads to better long-term desired outcomes. This paper identifies the association between collaborative reproductive health (CRH project management and sustainable outcomes. The Guide to the Project Management Body of Knowledge (PMBOK® Guide is employed to benchmark project management practices on four CRH projects in Thailand. The research methodology presented in this paper comprises of content analysis and questionnaire survey. It is evident that limited use of certain project management knowledge areas (PMKAs affects CRH project implementation and success. The association between the use of PMKAs and sustainable outcomes on these projects is also presented. Scope, integration and quality management were found to be the most influential PMKAs for sustainable outcomes on CRH projects. Nevertheless, the projects showed a shortage of project management processes for PMKAs that were required to attain the outcomes.

  19. Evolutionary Autonomous Health Monitoring System (EAHMS) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — For supporting NASA's Robotics, Tele-Robotics and Autonomous Systems Roadmap, we are proposing the "Evolutionary Autonomous Health Monitoring System" (EAHMS) for...

  20. Three-Dimensional Health Monitoring of Sandwich Composites Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR project delivers a single-chip structural health-monitoring (SHM) system that uses the impedance method to monitor bulk interiors and wave propagation...

  1. Sources of project financing in health care systems.

    Science.gov (United States)

    Smith, D G; Wheeler, J R; Rivenson, H L; Reiter, K L

    2000-01-01

    Through discussions with chief financial officers of leading health care systems, insights are offered on preferences for project financing and development efforts. Data from these same systems provide at least anecdotal evidence in support of pecking-order theory.

  2. Cyclic disulfide C8 iminoporfiromycin: nucleophilic activation of a porfiromycin.

    Science.gov (United States)

    Lee, Sang Hyup; Kohn, Harold

    2004-04-01

    The clinical success of mitomycin C (1) and its associated toxicities and resistance have led to efforts to prepare semisynthetic analogues (i.e., KW-2149 (3), BMS-181174 (4)) that have improved pharmacological profiles. In this study, we report the preparation and evaluation of the novel 7-N-(1'-amino-4',5'-dithian-2'-yl)porfiromycin C(8) cyclized imine (6) and its reference compound, 7-N-(1'-aminocyclohex-2'-yl)porfiromycin C(8) cyclized imine (13). Porfiromycin 6 contains a disulfide unit that, upon cleavage, may provide thiol(s) that affect drug reactivity. We demonstrated that phosphines dramatically accelerated 6 activation and solvolysis in methanolic solutions ("pH 7.4") compared with 13. Porfiromycins 6 and 13 efficiently cross-linked EcoRI-linearized pBR322 DNA upon addition of Et3P. We found enhanced levels of interstrand cross-link (ISC) adducts for 6 and 13 compared with porfiromycin (7) and that 6 was more efficient than 13. The large Et3P-mediated rate enhancements for the solvolysis of 6 compared with 13 and a N(7)-substituted analogue of 1, and the increased levels of ISC adducts for 6 compared with 13 and 7 are attributed to a nucleophile-assisted disulfide cleavage process that permits porfiromycin activation and nucleophile (MeOH, DNA) adduction. The in vitro antiproliferative activities of 6 and 13 using the A549 tumor cell line (lung adenocarcinoma) were determined under aerobic and hypoxic conditions and then compared with 7. Both 6 and 13 were more cytotoxic than 7, with 13 being more potent than 6. The C(8) iminoporfiromycins 6 and 13 displayed anticancer profiles similar to 3. PMID:15053618

  3. Architecture for Integrated System Health Management Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Managing the health of vehicle, crew, and habitat systems is a primary function of flight controllers today. We propose to develop an architecture for automating...

  4. Electronic Prognostics for Vehicle Health Management Project

    Data.gov (United States)

    National Aeronautics and Space Administration — All electronic systems are prone to wear-out and eventual failure and this has direct implications for Vehicle Health Management for NASA with its long space...

  5. Advertising a "Healthy Lifestyle:" A Cypriot Health Education Project

    Science.gov (United States)

    Ioannou, Soula

    2006-01-01

    This paper describes a health education program entitled "Young Consumer" project, financed by the European Union and implemented by the Cyprus Consumer Association between March and June 2004. The aim of the project was to promote a healthy lifestyle among a group of Cypriot primary school pupils (11-12 years old). Participants were asked to…

  6. [Health impact assessment of building and investment projects].

    Science.gov (United States)

    Thriene, B

    2003-02-01

    For regional planning and approval procedures for building projects of a certain order of magnitude and power rating according to the German Federal Act on the Prevention of Emissions with Integrated Environmental Impact Assessment (EIA), the German public health departments, acting as public authorities, increasingly perform health impact assessments (HIA). The amended Act on Environmental Impact Assessment, the Decree on industrial plants which require approval (4th Federal Decree on Emission Prevention) and the Health Service Acts of the Federal States of Germany form the legal basis for the assessment of health issues with regard to approval procedures for building and investment projects. In the framework of the "Action Programme for the Environment and Health", the present article aims at making this process binding and to ensure responsibility and general involvement of the Public Health departments in all German Federal States. Future criteria, basic principles and procedures for single-case testing as well as assessment standards should meet these requirements. The Federal Ministry for the Environment and the Federal Ministry for Health should agree on Health Impact Assessment (HIA ) as well as on the relaxant stipulations in their procedures and general administrative regulations for implementing the Environmental Impact Assessment Act (EIA). Current EIA procedures focus on urban development and road construction, industrial investment projects, intensive animal husbandry plants, waste incineration plants, and wind energy farms. This paper illustrates examples meeting with varying degrees of public acceptance. However, being involved in the regional planning procedure for the project "Extension of the federal motorway A 14 from Magdeburg to Schwerin", the Public Health Service also shares global responsibility for health and climate protection. Demands for shortest routing conflict with objectives of environmental protection which should be given long

  7. Copenhagen Infant Mental Health Project (CIMHP)

    DEFF Research Database (Denmark)

    Væver, Mette Skovgaard; Smith-Nielsen, Johanne; von Wowern, Rie Krondorf;

    Introduction: Infant mental health is a significant public health issue as early adversity and childhood stress has life-long consequences for the affected children. One in five Danish families is at risk of inadequate parenting resources and child neglect. There is a lack of knowledge on best...... these risks in a cost effective way in a general population. Methods: In a period of 20 months 8.800 mothers and infants in Copenhagen are screened (at 2, 4 and 8 months) using two standardized screening instruments: 1) Alarm Distress Baby Scale (ADBB) in detecting infant social withdrawal and 2) Edinburg...... effective these will represent a notable advance to initiating this system as a better infant mental health strategy in Denmark....

  8. Project HealthDesign: Stimulating the Next Generation of Personal Health Records

    OpenAIRE

    Brennan, Patricia Flatley; Downs, Stephen; Casper, Gail; Kenron, Daniel

    2007-01-01

    Project HealthDesign is a national program designed to rethink the power and potential of personal health records. It intends to stimulate development of new personal health management tools by harnessing the content of the personal health record and making advice, recommendations, and data-tracking tools available to lay people. The program goals include creating a set of prototype personal health records applications, deriving the core functions needed to support interoperable ‘plug-and-pla...

  9. Health Impact Assessment of an oil drilling project in California

    Directory of Open Access Journals (Sweden)

    Lindsay C. McCallum

    2016-04-01

    Full Text Available Objectives: The Health Impact Assessment (HIA was conducted to evaluate the potential community health implications of a proposed oil drilling and production project in Hermosa Beach, California. The HIA considered 17 determinants of health that fell under 6 major categories (i.e., air quality, water and soil quality, upset conditions, noise and light emissions, traffic, and community livability. Material and Methods: This paper attempts to address some of the gaps within the HIA practice by presenting the methodological approach and results of this transparent, comprehensive HIA; specifically, the evaluation matrix and decision-making framework that have been developed for this HIA and form the basis of the evaluation and allow for a clear conclusion to be reached in respect of any given health determinant (i.e., positive, negative, neutral. Results: There is a number of aspects of the project that may positively influence health (e.g., increased education funding, ability to enhance green space, and at the same time there have been potential negative effects identified (e.g., odor, blowouts, property values. Except for upset conditions, the negative health outcomes have been largely nuisance-related (e.g., odor, aesthetics without irreversible health impacts. The majority of the health determinants, that had been examined, have revealed that the project would have no substantial effect on the health of the community. Conclusions: Using the newly developed methodology and based on established mitigation measures and additional recommendations provided in the HIA, the authors have concluded that the project will have no substantial effect on community health. This approach and methodology will assist practitioners, stakeholders and decision-makers in advancing the HIA as a useful, reproducible, and informative tool.

  10. Financing health development projects: some macro-economic considerations.

    Science.gov (United States)

    Sorkin, A L

    1986-01-01

    The paper briefly discusses the importance of macro-economic policy in health sector financing. The ways in which monetary and fiscal policy (macro-economic policy) affect interest rates, price levels and aggregate output are presented. The main portion of the paper considers a variety of methods for public financing of health and development projects. These approaches are analyzed in light of distributional and efficiency considerations. One way of increasing health sector resources is through reallocation from other sectors of the economy. The potential for redistribution from the defense to the health service industry is briefly considered. PMID:3961549

  11. Project management success in health : the need of additional research in public health projects

    OpenAIRE

    Santos, Carolina; Santos, Vitor; Tavares, António J.; Varajão, João

    2014-01-01

    PROJMAN 2014 - International Conference on Project MANagement, Procedia Technology The research about the factors that are linked to project management performance and project management success, has been developed for several years, so the literature about this subject is relatively extensive. After a literature review about project success factors, it was found that the current research effort is mainly focused on information technology, engineering and software development proj...

  12. Structural and functional insights into CYP2C8.3:A genetic polymorph of cytochrome P450 2C8

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The cytochrome P450 (CYP) superfamily plays a key role in the oxidative metabolism of a wide range of exogenous chemicals. CYP2C8 is the principal enzyme responsible for the metabolism of the anti-cancer drug paclitaxel in the human liver, and carries out the oxidative metabolism of at least 5% of clinical drugs. Polymorphisms in CYP2C8 have been closely implicated in individualized medication. CYP2C8.3, a common polymorph of CYP2C8 with dual amino acid substitutions R139K and K399R, is found primarily in Caucasians. In this study, CYP2C8.3 and its wild type (WT) CYP2C8 were expressed in E. coli, and their purified proteins were characterized by UV-visible spectroscopy, mass spectrometry, and circular dichroism. Their thermal stability, substrate binding ability, and metabolic activity against paclitaxel were investigated. The electron transfer kinetics during paclitaxel metabolism by WT CYP2C8 or CYP2C8.3 was studied by stopped-flow kinetics. The results revealed that mutations in CYP2C8.3 did not greatly influence the heme active site or protein thermal stability and paclitaxel binding ability, but the metabolic activity against paclitaxel was significantly depressed to just 11% of that of WT CYP2C8. Electron transfer from CYP reductase to CYP2C8.3 was found to be significantly slower than that to WT CYP2C8 during catalysis, and this might be the main reason for the depressed metabolic activity. Since the polymorph CYP2C8.3 is defective in catalyzing substrates of CYP2C8 in vitro, it might be expected to have important clinical and pathophysiological consequences in homozygous individuals, and this study provides valuable information in this aspect.

  13. Molecular cloning of the alpha subunit of complement component C8 (CpC8α) of whitespotted bamboo shark (Chiloscyllium plagiosum).

    Science.gov (United States)

    Wang, Ying; Zhang, Mengmeng; Wang, Conghui; Ye, Boping; Hua, Zichun

    2013-12-01

    Complement-mediated cytolysis is the important effect of immune response, which results from the assembly of terminal complement components (C5b-9). Among them, α subunit of C8 (C8α) is the first protein that traverses the lipid bilayer, and then initiates the recruitment of C9 molecules to form pore on target membranes. In this article, a full-length cDNA of C8α (CpC8α) is identified from the whitespotted bamboo shark (Chiloscyllium plagiosum) by RACE. The CpC8α cDNA is 2183 bp in length, encoding a protein of 591 amino acids. The deduced CpC8α exhibits 89%, 49% and 44% identity with nurse shark, frog and human orthologs, respectively. Sequence alignment indicates that the C8α is well conserved during the evolution process from sharks to mammals, with the same modular architecture as well as the identical cysteine composition in the mature protein. Phylogenetic analysis places CpC8α and nurse shark C8α in cartilaginous fish clade, in parallel with the teleost taxa, to form the C8α cluster with higher vertebrates. Hydrophobicity analysis also indicates a similar hydrophobicity of CpC8α to mammals. Finally, expression analysis revealed CpC8α transcripts were constitutively highly expressed in shark liver, with much less expression in other tissues. The well conserved structure and properties suggests an analogous function of CpC8α to mammalian C8α, though it remains to be confirmed by further study.

  14. Sport, Physical Education And Coaching in Health (SPEACH) project

    OpenAIRE

    Jong, Johan de

    2015-01-01

    Main goal of the Sport Physical Education And Coaching in Health Project (SPEACH/Erasmus+ 557083-EPP-1-2014-1-NL-SPO-SCP) is to increase awareness and behavioural change in sport professionals and European citizens towards an active and healthy lifestyle. Sedentariness and physical inactivity are a cross-national problem. Therefore, the Project builds upon a strong collaborative-partnership to contribute in solving this problem on the European level and to increase sport and physical activity...

  15. Validity of recall absent schoolchildren to free eye health projects

    OpenAIRE

    Regina Noma; Regina de Souza Carvalho; Newton Kara-José

    2012-01-01

    PURPOSE: To analyze the results of recall absent schoolchildren to eye health projects. METHODS: Cross-sectional study. Visual screening was performed in schoolchildren attending 1st to 4th grades at public schools, from 7 to 10 years-old, to select and forward to complete ophthalmic evaluation. The projects were performed during weekends, at a public school, in the same municipality. Free transportation, food and eyeglasses were offered. A second opportunity of examination was offered to the...

  16. Telemedicine in Primary Health: The Virtual Doctor Project Zambia

    Directory of Open Access Journals (Sweden)

    Mustarde Paul

    2011-05-01

    Full Text Available Abstract This paper is a commentary on a project application of telemedicine to alleviate primary health care problems in Lundazi district in the Eastern province of Zambia. The project dubbed 'The Virtual Doctor Project' will use hard body vehicles fitted with satellite communication devices and modern medical equipment to deliver primary health care services to some of the neediest areas of the country. The relevance and importance of the project lies in the fact that these areas are hard-to-reach due to rugged natural terrain and have very limited telecommunications infrastructure. The lack of these and other basic services makes it difficult for medical personnel to settle in these areas, which leads to an acute shortage of medical personnel. We comment on this problem and how it is addressed by 'The Virtual Doctor Project', emphasizing that while the telemedicine concept is not new in sub-Saharan Africa, the combination of mobility and connectivity to service a number of villages 'on the go' is an important variation in the shift back to the 1978 Alma Ata principles of the United Nations World Health Organization [WHO]. This overview of the Virtual Doctor Project in Zambia provides insight into both the potential for ICT, and the problems and limitations that any "real-world" articulation of this technology must confront.

  17. Economic evaluation in primary health care: the case of Western Kenya community based health care project.

    Science.gov (United States)

    Wang'ombe, J K

    1984-01-01

    This paper describes the methodology and presents preliminary results of an economic appraisal of a community based health care project in Kenya. Community health workers, trained for 12 weeks and deployed in two locations in Kenya's Western Province, act as first contact providers of basic health care and promoters of selected health, sanitation and nutrition practices. A Cost Benefit Analysis has been undertaken using the Willingness to Pay approach to compare the costs of the project and its benefits. The benefits are in the form of more easily accessible basic health care and are measured as consumer surplus accruing to the community. Gain in consumer surplus is consequent on the fall of average user costs and rise in utilisation of the project established points of first contact with primary health care. The argument for the economic viability of the project is validated by the large Net Present Value and Benefit Cost Ratio obtained for the whole of the project area and for the two locations separately. Although the evaluation technique used faces the problem of valuation of community time, aggregation of health care services at all points of first contact and the partial nature of cost benefit analysis evaluations, the results are strongly in favour of decentralisation of primary health care on similar lines in the rest of the country. PMID:6427933

  18. Outcomes evaluation of the school staff health promotion project

    OpenAIRE

    Magdalena Woynarowska-Sołdan

    2016-01-01

    Background: This article presents selected outcomes of a 3-year projectHealth promotion of school staff in health-promoting schools,” as well as the achievements and difficulties in its implementation. Material and Methods: The research was conducted on 644 teachers and 226 members of non-teaching staff in 21 schools. The method involved opinion poll and authored questionnaires. A 2-part model of outcome evaluation was developed. Results: Most participants appreciated the changes that took ...

  19. Delivering health information services and technologies to urban community health centers: the Chicago AIDS Outreach Project.

    Science.gov (United States)

    Martin, E R; McDaniels, C; Crespo, J; Lanier, D

    1997-10-01

    Health professionals cannot address public health issues effectively unless they have immediate access to current biomedical information. This paper reports on one mode of access, the Chicago AIDS Outreach Project, which was supported by the National Library of Medicine through outreach awards in 1995 and 1996. The three-year project is an effort to link the programs and services of the University of Illinois at Chicago Library of the Health Sciences and the Midwest AIDS Training and Education Center with the clinic services of community-based organizations in Chicago. The project was designed to provide electronic access to AIDS-related information for AIDS patients, the affected community, and their care givers. The project also provided Internet access and training and continued access to library resources. The successful initiative suggests a working model for outreach to health professionals in an urban setting.

  20. Sport, Physical Education And Coaching in Health (SPEACH) project

    NARCIS (Netherlands)

    Jong, Johan de

    2015-01-01

    Main goal of the Sport Physical Education And Coaching in Health Project (SPEACH/Erasmus+ 557083-EPP-1-2014-1-NL-SPO-SCP) is to increase awareness and behavioural change in sport professionals and European citizens towards an active and healthy lifestyle. Sedentariness and physical inactivity are a

  1. Health and Environment Project In Benin

    Directory of Open Access Journals (Sweden)

    Raphaël Edou

    2010-02-01

    Full Text Available In 1989, the Republic of Benin was facing great social and economic upheavals. In 1990, the Canadian and American Mennonite missionaries created the Bethesda Health Care Centre.  In 1993, assessment of the hospital activities showed that many people were coming back to the centre repeatedly with the same illnesses linked to sanitation aspects and living conditions. The Community Development and Environmental Protection Department (DCAM was thus established to face this great challenge. It quickly helped the community and the local authorities to establish a waste management system.  The Programme for Sanitation and Protection of the Environment (PrAPE was designed and funded by the French Embassy and Evangelische Entwicklungsdienst V.e (EED, a German Christian organization. Households then began to subscribe for the collection of their wastes. Bethesda began to assist other communities to put in place waste management systems. Today, it is working throughout the country with many municipalities. While the programme was being implemented, we discovered that the community needed to be supported in their revenue generating activities. We set up in 1996, a solidarity-based microfinance system. The savings of some people were used to grant credit to others. This community bank has developed into a large bank today. In 2006, a system of mutual insurance was put in place. A complete integrated system to address the basic needs of the community was thus set up.En 1989, la République du Bénin a été confrontée à d’importants bouleversements sociaux et économiques. En 1990, des missionnaires mennonites canadiens et américains ont créé le Centre de santé Bethesda. En 1993, l’évaluation des activités hospitalières a montré que de nombreuses personnes revenaient à plusieurs reprises au centre avec les mêmes maladies liées à des problèmes d’assainissement et aux conditions de vie. Le département Développement Communautaire et

  2. Strengthening global health security capacity--Vietnam demonstration project, 2013.

    Science.gov (United States)

    Tran, Phu Dac; Vu, Long Ngoc; Nguyen, Hien Tran; Phan, Lan Trong; Lowe, Wayne; McConnell, Michelle S; Iademarco, Michael F; Partridge, Jeffrey M; Kile, James C; Do, Trang; Nadol, Patrick J; Bui, Hien; Vu, Diep; Bond, Kyle; Nelson, David B; Anderson, Lauren; Hunt, Kenneth V; Smith, Nicole; Giannone, Paul; Klena, John; Beauvais, Denise; Becknell, Kristi; Tappero, Jordan W; Dowell, Scott F; Rzeszotarski, Peter; Chu, May; Kinkade, Carl

    2014-01-31

    Over the past decade, Vietnam has successfully responded to global health security (GHS) challenges, including domestic elimination of severe acute respiratory syndrome (SARS) and rapid public health responses to human infections with influenza A(H5N1) virus. However, new threats such as Middle East respiratory syndrome coronavirus (MERS-CoV) and influenza A(H7N9) present continued challenges, reinforcing the need to improve the global capacity to prevent, detect, and respond to public health threats. In June 2012, Vietnam, along with many other nations, obtained a 2-year extension for meeting core surveillance and response requirements of the 2005 International Health Regulations (IHR). During March-September 2013, CDC and the Vietnamese Ministry of Health (MoH) collaborated on a GHS demonstration project to improve public health emergency detection and response capacity. The project aimed to demonstrate, in a short period, that enhancements to Vietnam's health system in surveillance and early detection of and response to diseases and outbreaks could contribute to meeting the IHR core capacities, consistent with the Asia Pacific Strategy for Emerging Diseases. Work focused on enhancements to three interrelated priority areas and included achievements in 1) establishing an emergency operations center (EOC) at the General Department of Preventive Medicine with training of personnel for public health emergency management; 2) improving the nationwide laboratory system, including enhanced testing capability for several priority pathogens (i.e., those in Vietnam most likely to contribute to public health emergencies of international concern); and 3) creating an emergency response information systems platform, including a demonstration of real-time reporting capability. Lessons learned included awareness that integrated functions within the health system for GHS require careful planning, stakeholder buy-in, and intradepartmental and interdepartmental coordination and

  3. HOW TO DEVELOP PROJECTS OF ATTENTION TOWARDS MENTAL HEALTH INSIDE THE PROGRAM OF FAMILY HEALTH

    Directory of Open Access Journals (Sweden)

    Rosangela Maria Fenili

    2003-12-01

    Full Text Available The development of projects of attention towards mental health inside the Program of Family Health(PFH is presented based on a brief rescue of some aspects that compose the PFH, the Psychiatric Reform/MentalHealth and the Unique Heath System. The insertion of attentive actions towards mental health in the PFH from theexistence and the non-existence of one of the substitutives services of the mental health net around the cities,points out some articulation possibilities and an united development of how to do it.

  4. eHealth for Remote Regions: Findings from Central Asia Health Systems Strengthening Project.

    Science.gov (United States)

    Sajwani, Afroz; Qureshi, Kiran; Shaikh, Tehniat; Sayani, Saleem

    2015-01-01

    Isolated communities in remote regions of Afghanistan, Kyrgyz Republic, Pakistan and Tajikistan lack access to high-quality, low-cost health care services, forcing them to travel to distant parts of the country, bearing an unnecessary financial burden. The eHealth Programme under Central Asia Health Systems Strengthening (CAHSS) Project, a joint initiative between the Aga Khan Foundation, Canada and the Government of Canada, was initiated in 2013 with the aim to utilize Information and Communication Technologies to link health care institutions and providers with rural communities to provide comprehensive and coordinated care, helping minimize the barriers of distance and time. Under the CAHSS Project, access to low-cost, quality health care is provided through a regional hub and spoke teleconsultation network of government and non-government health facilities. In addition, capacity building initiatives are offered to health professionals. By 2017, the network is expected to connect seven Tier 1 tertiary care facilities with 14 Tier 2 secondary care facilities for teleconsultation and eLearning. From April 2013 to September 2014, 6140 teleconsultations have been provided across the project sites. Additionally, 52 new eLearning sessions have been developed and 2020 staff members have benefitted from eLearning sessions. Ethics and patient rights are respected during project implementation. PMID:25980715

  5. Researchers' experience with project management in health and medical research: Results from a post-project review

    Directory of Open Access Journals (Sweden)

    Elliott Elizabeth J

    2011-06-01

    Full Text Available Abstract Background Project management is widely used to deliver projects on time, within budget and of defined quality. However, there is little published information describing its use in managing health and medical research projects. We used project management in the Alcohol and Pregnancy Project (2006-2008 http://www.ichr.uwa.edu.au/alcoholandpregnancy and in this paper report researchers' opinions on project management and whether it made a difference to the project. Methods A national interdisciplinary group of 20 researchers, one of whom was the project manager, formed the Steering Committee for the project. We used project management to ensure project outputs and outcomes were achieved and all aspects of the project were planned, implemented, monitored and controlled. Sixteen of the researchers were asked to complete a self administered questionnaire for a post-project review. Results The project was delivered according to the project protocol within the allocated budget and time frame. Fifteen researchers (93.8% completed a questionnaire. They reported that project management increased the effectiveness of the project, communication, teamwork, and application of the interdisciplinary group of researchers' expertise. They would recommend this type of project management for future projects. Conclusions Our post-project review showed that researchers comprehensively endorsed project management in the Alcohol and Pregnancy Project and agreed that project management had contributed substantially to the research. In future, we will project manage new projects and conduct post-project reviews. The results will be used to encourage continuous learning and continuous improvement of project management, and provide greater transparency and accountability of health and medical research. The use of project management can benefit both management and scientific outcomes of health and medical research projects.

  6. 76 FR 6335 - Sodium and Potassium Salts of N-alkyl (C8

    Science.gov (United States)

    2011-02-04

    .... The linear fatty acid is metabolized via successive beta-oxidation cycles to release acetic acid and... AGENCY 40 CFR Part 180 Sodium and Potassium Salts of N-alkyl (C 8 - C 18 )-beta-iminodipropionic acid... residues of sodium and potassium salts of N-alkyl (C 8 -C 18 )-beta-iminodipropionic acid where the C 8...

  7. Project management educational curriculum for public health professionals: development and evaluation

    OpenAIRE

    David Sabapathy; David Strong; Hude Quan

    2011-01-01

    Successful completion of public health projects is critical to achieving population health objectives. However project execution can be challenging due to scarce time and resources, rapidly changing environments and complex stakeholder requirements. To address these challenges physicians and other professionals working in public health need to learn the practical skills of project management. However curricula tailored to project management skill development for public health professionals is...

  8. Project HealthDesign: stimulating the next generation of personal health records.

    Science.gov (United States)

    Brennan, Patricia Flatley; Downs, Stephen; Casper, Gail; Kenron, Daniel

    2007-01-01

    Project HealthDesign is a national program designed to rethink the power and potential of personal health to rethink the power and potential of personal health records. It intends to stimulate development of new personal health management tools by harnessing the content of the personal health record and making advice, recommendations, and data-tracking tools available to lay people. The program goals include creating a set of prototype personal health records applications, deriving the core functions needed to support interoperable 'plug-and-play' resources for managing health challenges, and addressing the ethical, legal, and social issues that confront the development of computer tools to promote health actions. Response to the call for proposals was tremendous; from the over 160 groups who submitted proposals, 9 teams were selected to design and create prototypes of innovative personal health management tools. This paper summarizes the full set of proposals, their populations of interest, and the technical challenges that await full implementation of the PHR-based applications designed to promote health. PMID:18693800

  9. The Korean Social Life, Health and Aging Project-Health Examination Cohort

    OpenAIRE

    Lee, Ju-Mi; Lee, Won Joon; Kim, Hyeon Chang; Choi, Wungrak; Lee, Jina; Sung, Kiho; Chu, Sang Hui; Park, Yeong-Ran; Youm, Yoosik

    2014-01-01

    The Korean Social Life, Health, and Aging Project (KSHAP) is a population-based longitudinal study of health determinants among elderly Koreans. The target population of the KSHAP are people aged 60 years or older and their spouses living in a rural community of Korea. A complete enumeration survey was conducted in the first wave of the KSHAP on 94.7% (814 of 860) of the target population between December 2011 and July 2012. The KSHAP-Health Examination (KSHAP-HE) cohort consists of 698 peopl...

  10. Involving Community Health Workers in the Centers for Population Health and Health Disparities Research Projects: Benefits and Challenges.

    Science.gov (United States)

    Krok-Schoen, Jessica L; Weier, Rory C; Hohl, Sarah D; Thompson, Beti; Paskett, Electra D

    2016-01-01

    Understanding the benefits and challenges of including community health workers (CHWs) in health disparities research can improve planning and delivery of culturally appropriate interventions. Representatives from 18 projects from the Centers for Population Health and Health Disparities (CPHHD) initiative completed an online questionnaire about the benefits and challenges of involving CHWs in their research. Eight emergent themes were classified into two categories: 1) Personal qualities and background CHWs bring to research including community knowledge and cultural sensitivity to improve recruitment and effectiveness of interventions; and 2) Workplace demands of CHWs including human resource policies and processes, research skills/background (training needs), and oversight despite distance. These findings demonstrate the benefits of involving CHWs in research and draw attention to the hiring, training, and oversight of CHWs and subsequent challenges. Additional research is needed to understand interactions between project staff and CHWs better and to identify best practices to involve CHWs in research. PMID:27524766

  11. Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions.

    Science.gov (United States)

    Backman, Janne T; Filppula, Anne M; Niemi, Mikko; Neuvonen, Pertti J

    2016-01-01

    During the last 10-15 years, cytochrome P450 (CYP) 2C8 has emerged as an important drug-metabolizing enzyme. CYP2C8 is highly expressed in human liver and is known to metabolize more than 100 drugs. CYP2C8 substrate drugs include amodiaquine, cerivastatin, dasabuvir, enzalutamide, imatinib, loperamide, montelukast, paclitaxel, pioglitazone, repaglinide, and rosiglitazone, and the number is increasing. Similarly, many drugs have been identified as CYP2C8 inhibitors or inducers. In vivo, already a small dose of gemfibrozil, i.e., 10% of its therapeutic dose, is a strong, irreversible inhibitor of CYP2C8. Interestingly, recent findings indicate that the acyl-β-glucuronides of gemfibrozil and clopidogrel cause metabolism-dependent inactivation of CYP2C8, leading to a strong potential for drug interactions. Also several other glucuronide metabolites interact with CYP2C8 as substrates or inhibitors, suggesting that an interplay between CYP2C8 and glucuronides is common. Lack of fully selective and safe probe substrates, inhibitors, and inducers challenges execution and interpretation of drug-drug interaction studies in humans. Apart from drug-drug interactions, some CYP2C8 genetic variants are associated with altered CYP2C8 activity and exhibit significant interethnic frequency differences. Herein, we review the current knowledge on substrates, inhibitors, inducers, and pharmacogenetics of CYP2C8, as well as its role in clinically relevant drug interactions. In addition, implications for selection of CYP2C8 marker and perpetrator drugs to investigate CYP2C8-mediated drug metabolism and interactions in preclinical and clinical studies are discussed. PMID:26721703

  12. [Anthropology and oral health projects in developing countries].

    Science.gov (United States)

    Grasveld, A E

    2016-07-01

    The mouth and teeth play an important role in social interactions around the world. The way people deal with their teeth and mouth, however, is determined culturally. When oral healthcare projects are being carried out in developing countries, differing cultural worldviews can cause misunderstandings between oral healthcare providers and their patients. The oral healthcare volunteer often has to try to understand the local assumptions about teeth and oral hygiene first, before he or she can bring about a change of behaviour, increase therapy compliance and make the oral healthcare project sustainable. Anthropology can be helpful in this respect. In 2014, in a pilot project commissioned by the Dutch Dental Care Foundation, in which oral healthcare was provided in combination with anthropological research, an oral healthcare project in Kwale (Kenia) was evaluated. The study identified 6 primary themes that indicate the most important factors influencing the oral health of school children in Kwale. Research into the local culture by oral healthcare providers would appear to be an important prerequisite to meaningful work in developing countries. PMID:27430039

  13. TPS In-Flight Health Monitoring Project Progress Report

    Science.gov (United States)

    Kostyk, Chris; Richards, Lance; Hudston, Larry; Prosser, William

    2007-01-01

    Progress in the development of new thermal protection systems (TPS) is reported. New approaches use embedded lightweight, sensitive, fiber optic strain and temperature sensors within the TPS. Goals of the program are to develop and demonstrate a prototype TPS health monitoring system, develop a thermal-based damage detection algorithm, characterize limits of sensor/system performance, and develop ea methodology transferable to new designs of TPS health monitoring systems. Tasks completed during the project helped establish confidence in understanding of both test setup and the model and validated system/sensor performance in a simple TPS structure. Other progress included complete initial system testing, commencement of the algorithm development effort, generation of a damaged thermal response characteristics database, initial development of a test plan for integration testing of proven FBG sensors in simple TPS structure, and development of partnerships to apply the technology.

  14. The CYP2C8 inhibitor gemfibrozil does not affect the pharmacokinetics of zafirlukast

    OpenAIRE

    Karonen, Tiina; Neuvonen, Pertti J; Backman, Janne T.

    2010-01-01

    Abstract Purpose Gemfibrozil, a strong inhibitor of cytochrome P450 (CYP) 2C8 in vivo, was recently found to markedly increase the plasma concentrations of montelukast in humans. Like montelukast, zafirlukast is a substrate of CYP2C9 and CYP3A4 and a potent inhibitor of CYP2C8 in vitro. To investigate the contribution of CYP2C8 to the metabolism of zafirlukast in vivo, we studied the effect of gemfibrozil on the pharmacokinetics of zafirlukast. ...

  15. Project Jump: Young People's Perspectives on a Sexual Health Drama Project for Hard to Reach Young People

    Science.gov (United States)

    Orme, Judy; Salmon, Debra; Mages, Linda

    2007-01-01

    This article explores the qualitative process findings from an evaluation of Project Jump--a sexual health drama project for hard to reach young people. Project Jump aimed to enable young people to consider their sexual behaviour and its impact and consequence on other people and themselves. The research aimed to capture the experiences and…

  16. Project management educational curriculum for public health professionals: development and evaluation

    Directory of Open Access Journals (Sweden)

    David Sabapathy

    2011-06-01

    Full Text Available Successful completion of public health projects is critical to achieving population health objectives. However project execution can be challenging due to scarce time and resources, rapidly changing environments and complex stakeholder requirements. To address these challenges physicians and other professionals working in public health need to learn the practical skills of project management. However curricula tailored to project management skill development for public health professionals is not widely available. A one-week curriculum on project management for public health professionals has been developed enabling participants to independently lead small-scale public health projects. This course adapts a private-sector curriculum for use in public health practice and incorporates a unique skill-building teaching method. Evaluation of the initial curriculum delivery at the Weill-Bugando University, Tanzania indicated the majority of students intended to use project management upon return to their positions in public health. Students indicated a lack of a critical mass of public health professionals with required knowledge and skills represents the greatest barrier to integration of project management into public health practice. A unique one-week curriculum in project management has been developed and is being made publicly available. The course will enable physicians and other professionals working in public health to rapidly learn and apply the methodology to the front lines of public health.

  17. EULID project: European living donation and public health.

    Science.gov (United States)

    Manyalich, M; Ricart, A; Martínez, I; Balleste, C; Paredes, D; Vilardell, J; Avsec, D; Dias, L; Fehrman-Eckholm, I; Hiesse, C; Kyriakides, G; Line, P D; Maxwell, A; Nanni Costa, A; Paez, G; Turcu, R; Walaszewski, J

    2009-01-01

    The choice of transplantation from a living donor offers advantages over a deceased donor. However, it also carries disadvantages related to donor risks in terms of health and safety. Furthermore, there are several controversial ethical aspects to be taken into account. Several national and international institutions and the scientific community have stated standards that have great influence on professional codes and legislations. Living organ donation and transplantation are to some extent regulated by parliamentary acts in most European countries. It is necessary to take a step forward to develop a legal framework to regulate all of these processes to guarantee the quality and to prevent illegal and nonethical practices. It is also necessary to develop and implement living donor protection practices not only in terms of physical health, but also to minimize potential impacts on the psychological, social, and economic spheres. Finally, an additional effort should be made to create a database model with recommendations for registration practices as part of the standardized follow-up care for the living donor. The European Living Donation (EULID) project's (http://www.eulivingdonor.eu/) main objective was to contribute to a European consensus to set standards and recommendations about legal, ethical, and living donor protection practices to guarantee the health and safety of living donors. PMID:19715823

  18. Mother and child health project in Bragin district

    International Nuclear Information System (INIS)

    constituted 4.5 % (668 cases) in 2001 already 5.5 % (806 cases) from the total number of the children born. Further problems are:predominance of stationary assistance in primary health care; absence of interdisciplinary approach and of decentralization of medical treatment; lack of the main kinds of equipment, spare materials and medications, which are necessary for providing medical treatment; difficulty for rural population in accessing the available medical services: long distances, absence of information, low interaction with medical personnel; low sanitary culture among women (contraceptives are not used, the cases of unwanted pregnancies occur very often, STD problems, late notification of the doctor when the child is getting ill); giving birth to children as a means of getting state subsidy. In the framework of technical cooperation SDC supported Gomel' regional hospital some years ago with equipment for mother and child health care. The equipment (incubators, CO2 monitors) donated in 1996 to the delivery department and department for rehabilitation and intensive therapy are still in use and in good condition. This maternity hospital provides help to women from the Gomel' area with the most serious and difficult complications during the period of pregnancy. Sixty or seventy women come to this regional hospital from Bragin district every year, and it makes 40-50% of the whole number of deliveries in the district Bragin district in the very south of the Gomel area is one of the most contaminated areas in Belarus, where people still settle, hi order to help in solving the existing problems SDC in cooperation with local authorities is developing a mother and child health project for Bragin district. The aim of the project is to support and build up primary health care structures in the field of mother and child health. The duration of the project will be three years. The project consists of the following parts: community approach strategy to disseminate health messages on

  19. Health Education Field Experience Stories: A Reflective, Digital, Performance-Based Project

    Science.gov (United States)

    Lyde, Adrian R.

    2012-01-01

    This article describes a reflective, systematic, performance-based project resulting in the development of a digital story about a community health education field experience. The project is designed for preservice health education students at the college/university level. The primary benefit of the project is that it challenges students to engage…

  20. 26 CFR 1.381(c)(8)-1 - Installment method.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Installment method. 1.381(c)(8)-1 Section 1.381... (CONTINUED) INCOME TAXES Insolvency Reorganizations § 1.381(c)(8)-1 Installment method. (a) Carryover... corporation has elected under section 453 and the regulations thereunder to report on the installment...

  1. Social Determinants, Race, and Brain Health Outcomes: Findings from the Chicago Health and Aging Project.

    Science.gov (United States)

    Aggarwal, Neelum T; Everson-Rose, Susan A; Evans, Denis A

    2015-01-01

    The broad spectrum of economic and cultural diversity in the U.S. population correlates with and affects the study of behavioral aspects of health. The purpose of this article is to provide a selective overview of research findings from the Chicago Health and Aging Project (CHAP), which covers a socio-demographically diverse population in Chicago, with a focus on role-related psychosocial factors and observed racial/ethnic differences in aging outcomes. CHAP is a longitudinal, epidemiological study of common chronic conditions of aging with an emphasis on medical, psychosocial, and environmental risk factors for the decline in cognitive function across the older adult lifespan. We briefly summarize the study design and methods used in the CHAP study and characterize the study population and describe the psychosocial data, noting black-white associations as they relate to three common brain health outcomes: cognitive function and Alzheimer's Disease, stroke, and subclinical vascular disease as noted on neuroimaging. PMID:26239039

  2. Community participation in primary health care projects of the Muldersdrift Health and Development Programme

    Directory of Open Access Journals (Sweden)

    M. Barker

    2007-09-01

    Full Text Available After numerous teething problems (1974-1994, the Department of Nursing Education of WITS University took responsibility for the Muldersdrift Health and Development Programme (MHDP. The nursing science students explored and implemented an empowerment approach to community participation. The students worked with MHDP health workers to improve health through community participation, in combination with primary health care (PHC activities and the involvement of a variety of community groups. As the PHC projects evolved overtime, the need arose to evaluate the level of community participation and how much community ownership was present over decision-making and resources. This led to the question “What was the level of community participation in PHC projects of the MHDP?” Based on the question the following objectives were set, i.e. i to evaluate the community participation in PHC initiatives; ii to provide the project partners with motivational affirmation on the level of community participation criteria thus far achieved; iii to indicate to participants the mechanisms that should still be implemented if they wanted to advance to higher levels of community participation; iv to evaluate the MHDP’s implementation of a people-centred approach to community participation in PHC; and v the evaluation of the level of community participation in PHC projects in the MHDP. An evaluative, descriptive, contextual and quantitative research design was used. Ethical standards were adhered to throughout the study. The MHDP had a study population of twentythree (N=23 PHC projects. A purposive sample of seven PHC initiatives was chosen according to specific selection criteria and evaluated according to the “Criteria to evaluate community participation in PHC projects” instrument (a quantitative tool. Structured group interviews were done with PHC projects’ executive committee members. The Joint Management Committee’s data was collected through mailed

  3. [Community nutrition strategy project: an innovation in community health].

    Science.gov (United States)

    Diallo, I; Ndiaye, B; Pouye, A; Gaye, I A; Sy, A; Sarr, R; Tall-Dia, A

    1998-01-01

    The strategy of the community nutrition project is based on the utilization of the community development structures to deliver the nutrition services. These structures, represented in Senegal by youth associations, women groups, GIEs and NGOs, are part of the decentralization process, and as such play an important role in health and health development activities in poor urban districts. The Community Nutrition Project (CNP), funded for five years by the World Bank, German Cooperation (KFW), World Food Program (WFP) and the Senegalese government aims to halt further deterioration in the nutrition status of the most vulnerable groups in the poorest urban districts of Senegal. All nutrition services and particularly the IEC services have been entirely contracted out the first year to 76 GIEs involving 323 unemployed persons, operating as micro-enterprises "MIC" and 17 "GIEs" of unemployed physicians, pharmacists, and social workers for a total of 34 persons, organized as "maître d'Oeuvre communautaires "MOC", in charge of the supervision tasks. Each community nutrition center recruits and monitors every six months 460 to 600 beneficiaries composed of women at six months of pregnancy, lactating mother of children under 6 months, and a group of children aged from 6 to 35 months old. An average of 87% of registered children in the nutrition centers are weekly or monthly weighted. Thus the proportion of malnourished children in cohort of children followed from January to July 1996 has decreased from 70% to 25% within six months. The malnutrition rate has been reduced up to 65% after six months. PMID:10797950

  4. Role of cytochrome P450 2C8*3 (CYP2C8*3) in paclitaxel metabolism and paclitaxel-induced neurotoxicity

    DEFF Research Database (Denmark)

    Lee, Mi-Young; Apellániz-Ruiz, María; Johansson, Inger;

    2015-01-01

    AIM: The CYP2C8*3 allele has been suggested as a risk factor for paclitaxel-induced neuropathy but the data hitherto published are conflicting. MATERIALS & METHODS: In total 435 patients were investigated with respect to maximum neuropathy grade and accumulated paclitaxel dose. The enzymatic prop...

  5. The Diffusion of Health Economics Knowledge in Europe: The EURONHEED (European Network of Health Economics Evaluation Database) Project

    OpenAIRE

    Gerard de Pouvourville; Philippe Ulmann; John Nixon; Stephanie Boulenger; Julie Glanville; Michael Drummond

    2005-01-01

    This paper overviews the EURONHEED (EUROpean Network of Health Economics Evaluation Databases) project. Launched in 2003, this project is funded by the EU. Its aim is to create a network of national and international databases dedicated to health economic evaluation of health services and innovations. Seven centres (France, Germany, Italy, The Netherlands, Spain, Sweden and the UK) are involved covering 17 countries. The network is based on two existing databases, the French CODECS (COnnaissa...

  6. [Globalization, the Camisea Project and the Matsigenkas health].

    Science.gov (United States)

    Torres-Slimming, Paola

    2010-09-01

    Globalization has been the consequence of an important opening of the economies, achieved through the reduction in the obstacles to commerce, elimination of the capital controls and exchange restrictions. The impact of the Camisea Project in the Peruvian economy has aroused great interest and controversy with respect to the future social and economic national impact, and especially, in the Matsigenka population, located in the 88 and 56 lots, where gas extraction is being done. The area of Camisea gas exploitation offers the challenge of a complex sanitary problem, not only because of the impacts and risks produced by the hidrocarbon exploitation, but also due to a legacy of economical and sanitary precariousness that has accumulated from other times. At the same time, this area offers the opportunity to rethink the public health system according to the indigenous reality. It is necessary to take action in the social determinants of inequity and poverty in order to reach the positive effects the globalization can have in health, ensuring the interests of developing countries and vulnerable populations. PMID:21152741

  7. [Globalization, the Camisea Project and the Matsigenkas health].

    Science.gov (United States)

    Torres-Slimming, Paola

    2010-09-01

    Globalization has been the consequence of an important opening of the economies, achieved through the reduction in the obstacles to commerce, elimination of the capital controls and exchange restrictions. The impact of the Camisea Project in the Peruvian economy has aroused great interest and controversy with respect to the future social and economic national impact, and especially, in the Matsigenka population, located in the 88 and 56 lots, where gas extraction is being done. The area of Camisea gas exploitation offers the challenge of a complex sanitary problem, not only because of the impacts and risks produced by the hidrocarbon exploitation, but also due to a legacy of economical and sanitary precariousness that has accumulated from other times. At the same time, this area offers the opportunity to rethink the public health system according to the indigenous reality. It is necessary to take action in the social determinants of inequity and poverty in order to reach the positive effects the globalization can have in health, ensuring the interests of developing countries and vulnerable populations.

  8. Health and Maintenance Status Determination and Predictive Fault Diagnosis System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of this project is to demonstrate intelligent health and maintenance status determination and predictive fault diagnosis techniques for NASA rocket...

  9. Education projects: an opportunity for student fieldwork in global health academic programs.

    Science.gov (United States)

    Fyfe, Molly V

    2012-01-01

    Universities, especially in higher-income countries, increasingly offer programs in global health. These programs provide different types of fieldwork projects, at home and abroad, including: epidemiological research, community health, and clinical electives. I illustrate how and why education projects offer distinct learning opportunities for global health program fieldwork. As University of California students, we partnered in Tanzania with students from Muhimbili University of Health and Allied Science (MUHAS) to assist MUHAS faculty with a curricular project. We attended classes, clinical rounds, and community outreach sessions together, where we observed teaching, materials used, and the learning environment; and interviewed and gathered data from current students, alumni, and health professionals during a nationwide survey. We learned together about education of health professionals and health systems in our respective institutions. On the basis of this experience, I suggest some factors that contribute to the productivity of educational projects as global health fieldwork.

  10. Natural gas C3-C8 Hydrocarbon Enrichment Analysis Methods%天然气C3-C8烃类浓缩分析新方法

    Institute of Scientific and Technical Information of China (English)

    杨晓春; 王璋

    2015-01-01

    天然气形成的原因,但在一般情况下,天然气和油的成因是不同的,在天然气中,所用的有用信息数量不多。根据这一情况,自己配制了以C3—C8烃为主的天然气浓缩器,而当场就可以去井口搜集天然气的、浓缩的样品,在此基础上,形成了以天然气C3—C8烃为主的浓缩方法。对于该方法,能把天然气中的C3—C8烃类物质分析出来,从而完成了任务,即对天然气组分不多、气源相对不易,这是一个新的思路、方法,值得我们学习。%The causes of the formation of natural gas,but in general,the causes of natural gas an d oil are different,in natural gas,the small number of useful information.According to this situation,make myself a predominantly C3 - C8 hydrocarbon gas concentrator,and can go on the wellhead collecting gas,concentration of sample,on this basis,formed mainly gas C3 - C8 hydrocarbon enrichment method.For the method,can change the C3 - C8 hydrocarbons in natural gas analysis,so as to complete the task,namely a few components of natural gas,gas source is relatively difficult,this is a new train of thought,method and worth our learning.

  11. Validity of recall absent schoolchildren to free eye health projects

    Directory of Open Access Journals (Sweden)

    Regina Noma

    2012-02-01

    Full Text Available PURPOSE: To analyze the results of recall absent schoolchildren to eye health projects. METHODS: Cross-sectional study. Visual screening was performed in schoolchildren attending 1st to 4th grades at public schools, from 7 to 10 years-old, to select and forward to complete ophthalmic evaluation. The projects were performed during weekends, at a public school, in the same municipality. Free transportation, food and eyeglasses were offered. A second opportunity of examination was offered to the students who were absent from the first call, with the same facilities. RESULTS: 51,509 schoolchildren had their vision tested, 14,651 (28.4% were referred for ophthalmic examination. Of these, 8,683 (59.3% attended the first call, 2,228 (37.3% attended the recall and 25.5% of parents did not take their children to ophthalmic examination. The need for eyeglasses for children who attended the examination was 23.8% and 32.0% in the first opportunity and recall, respectively. The recall increased the coverage in 15.2% (59.3% to 74.5%. CONCLUSION: An expressive number of parents (25.5% did not bring their children to be examined, even at a second opportunity of exam. The facilities offered: access, free examination, transportation and glasses. Children who were absent in the first opportunity and appeared at recall had a greater need for eyeglasses. Recall increased the coverage in 15.2% (59.3% to 74.5% and it is not recommended when financial resources are limited.

  12. Experiences from three community health promotion projects in Greenland

    DEFF Research Database (Denmark)

    Curtis, Tine; Olesen, Ingelise; Kjeldsen, Ann B;

    2005-01-01

    with strong leadership and a central organisation, whereas the Qasigiannguit project was designed as a community project with population participation in all phases of the project. The two former projects have probably had a greater direct change impact on the community, whereas the latter has strengthened...

  13. Density equalizing map projections (cartograms) in public health applications

    Energy Technology Data Exchange (ETDEWEB)

    Merrill, D.W.

    1998-05-01

    In studying geographic disease distributions, one normally compares rates among arbitrarily defined geographic subareas (e.g. census tracts), thereby sacrificing some of the geographic detail of the original data. The sparser the data, the larger the subareas must be in order to calculate stable rates. This dilemma is avoided with the technique of Density Equalizing Map Projections (DEMP){copyright}. Boundaries of geographic subregions are adjusted to equalize population density over the entire study area. Case locations plotted on the transformed map should have a uniform distribution if the underlying disease risk is constant. On the transformed map, the statistical analysis of the observed distribution is greatly simplified. Even for sparse distributions, the statistical significance of a supposed disease cluster can be calculated with validity. The DEMP algorithm was applied to a data set previously analyzed with conventional techniques; namely, 401 childhood cancer cases in four counties of California. The distribution of cases on the transformed map was analyzed visually and statistically. To check the validity of the method, the identical analysis was performed on 401 artificial cases randomly generated under the assumption of uniform risk. No statistically significant evidence for geographic non-uniformity of rates was found, in agreement with the original analysis performed by the California Department of Health Services.

  14. Self-care project for faculty and staff of future health care professionals: Case report.

    Science.gov (United States)

    MacRae, Nancy; Strout, Kelley

    2015-01-01

    Self-care among health care providers is an important component of their ability to provide quality health care to patients. Health care institutions have programs in place for students that emphasize health and wellness, but few programs are available for faculty and staff. To address this gap and facilitate modeling health and wellness strategies for students, a New England institution that educates health care practitioners began a pilot self-care project for faculty and staff. Both quantitative and qualitative data were collected. The template used for this project could be used as a stepping-stone for future wellness self-care program in higher education for faculty, staff, and students.

  15. Yshareit: A Project Promoting the Use of E-Mental Health Resources among Young People

    Science.gov (United States)

    Spiranovic, Caroline; Briggs, Kate; Kirkby, Kenneth; Mobsby, Caroline; Daniels, Brett

    2008-01-01

    The yshareit project aims to increase awareness of and access to reputable e-mental health resources among young people. This is achieved by developing peer support networks, supported by e-mental health resources including the triage website, http://www.yshareit.com. Young people involved in the evaluation of the project described in this paper…

  16. Integrated Environment and Safety and Health Management System (ISMS) Implementation Project Plan

    Energy Technology Data Exchange (ETDEWEB)

    MITCHELL, R.L.

    2000-01-10

    The Integrated Environment, Safety and Health Management System (ISMS) Implementation Project Plan serves as the project document to guide the Fluor Hanford, Inc (FHI) and Major Subcontractor (MSC) participants through the steps necessary to complete the integration of environment, safety, and health into management and work practices at all levels.

  17. Latin American special project: kidney health cooperation project between Uruguay and Bolivia.

    Science.gov (United States)

    Sola, Laura; Plata-Cornejo, Raúl; Fernández-Cean, Juan

    2015-01-01

    Uruguay and Bolivia are two countries that show heterogenicity of the Latin American region, including the national income, the expenditure on health and the services for renal care. In Bolivia, there is manpower shortage for renal care with only 5 nephrologists per million people (pmp) and the prevalence of patients on dialysis is only 200 pmp. This is much lower than the mean prevalence rate of renal replacement therapy for Latin America as a whole. Uruguay on the other hand has more dedicated renal resources with 50 nephrologists pmp, and renal replacement therapy is provided to ~ 1,000 dialysis patients pmp. In November 2012, a collaborative project financed by the Uruguayan International Cooperation Agency was signed by both the Uruguay and Bolivia Ministries of Health, and the goal was to develop a comprehensive program for the prevention and management of all stages of chronic kidney disease (CKD) in Bolivia. The specific objectives were to: a) promote renal healthcare in the primary healthcare setting, b) identify kidney disease in populations at risk, and c) optimize patient care at all stages of CKD, including dialysis and transplantation supported with a national ESRD registry in Bolivia. As a first step, delegates from the Bolivian Health Ministry, visited Uruguay in April 2014, primarily to strengthen the development of tools required for developing and maintaining a national registry. In addition, during this visit, a meeting with the president of the Latin American Society of Nephrology and Hypertension (SLANH) culminated in designing a training program for peritoneal dialysis. This highly cooperative relationship is advancing the prevention and care of CKD in Bolivia and may serve as a model for international approaches to advance system level CKD care in countries with limited healthcare resources.

  18. Implementing a community-based social marketing project to improve agricultural worker health.

    OpenAIRE

    Flocks, J; Clarke, L; Albrecht, S.; Bryant, C; Monaghan, P.; Baker, H

    2001-01-01

    The Together for Agricultural Safety project is a community-based social marketing project working to reduce the adverse health effects of pesticide exposure among fernery and nursery workers in Florida. In 3 years, the collaboration between university and community researchers has embodied many of the principles of community-based research while completing multiple stages of formative data collection required for a social marketing project. This hybrid approach to developing a health interve...

  19. The European Donor Health Care Project: fulfilling needs and challenges for the future

    Directory of Open Access Journals (Sweden)

    P.J.M. van den Burg

    2014-05-01

    Full Text Available The Donor Health Care project is a EU granted project to develop a learning programme for professionals working in the field of Donor Health Care. The innovation of this curriculum is the focus on all donors, irrespective of whether they donate blood, cells, tissues or organs. This article describes the background of the project and the current possibilities and limitations of European accreditation, distance learning and Master degrees.

  20. Controlling of the optical properties of the solutions of the PTCDI-C8 organic semiconductor

    Science.gov (United States)

    Erdoğan, Erman; Gündüz, Bayram

    2016-09-01

    N,N'-Dioctyl-3,4,9,10 perylenedicarboximide (PTCDI-C8) organic semiconductor have vast applications in solar cells, thermoelectric generators, thin film photovoltaics and many other optoelectronic devices. These applications of the materials are based on their spectral and optical properties. The solutions of the PTCDI-C8 for different molarities were prepared and the spectral and optical mesaurements were analyzed. Effects of the molarities on optical properties were investigated. Vibronic structure has been observed based on the absorption bands of PTCDI-C8 semiconductor with seven peaks at 2.292, 2.451, 2.616, 3.212, 3.851, 4.477 and 4.733 eV. The important spectral parameteres such as molar/mass extinction coefficients, absorption coefficient of the PTCDI-C8 molecule were calculated. Optical properties such as angle of incidence/refraction, optical band gap, real and imaginary parts of dielectric constant, loss factor and electrical susceptibility of the the PTCDI-C8 were obtained. Finally, we discussed these parameters for optoelectronic applications and compared with related parameters in literature.

  1. Working with Climate Projections to Estimate Disease Burden: Perspectives from Public Health

    Science.gov (United States)

    Conlon, Kathryn C.; Kintziger, Kristina W.; Jagger, Meredith; Stefanova, Lydia; Uejio, Christopher K.; Konrad, Charles

    2016-01-01

    There is interest among agencies and public health practitioners in the United States (USA) to estimate the future burden of climate-related health outcomes. Calculating disease burden projections can be especially daunting, given the complexities of climate modeling and the multiple pathways by which climate influences public health. Interdisciplinary coordination between public health practitioners and climate scientists is necessary for scientifically derived estimates. We describe a unique partnership of state and regional climate scientists and public health practitioners assembled by the Florida Building Resilience Against Climate Effects (BRACE) program. We provide a background on climate modeling and projections that has been developed specifically for public health practitioners, describe methodologies for combining climate and health data to project disease burden, and demonstrate three examples of this process used in Florida. PMID:27517942

  2. Working with Climate Projections to Estimate Disease Burden: Perspectives from Public Health.

    Science.gov (United States)

    Conlon, Kathryn C; Kintziger, Kristina W; Jagger, Meredith; Stefanova, Lydia; Uejio, Christopher K; Konrad, Charles

    2016-01-01

    There is interest among agencies and public health practitioners in the United States (USA) to estimate the future burden of climate-related health outcomes. Calculating disease burden projections can be especially daunting, given the complexities of climate modeling and the multiple pathways by which climate influences public health. Interdisciplinary coordination between public health practitioners and climate scientists is necessary for scientifically derived estimates. We describe a unique partnership of state and regional climate scientists and public health practitioners assembled by the Florida Building Resilience Against Climate Effects (BRACE) program. We provide a background on climate modeling and projections that has been developed specifically for public health practitioners, describe methodologies for combining climate and health data to project disease burden, and demonstrate three examples of this process used in Florida. PMID:27517942

  3. Sensor Area Network for Integrated Systems Health Management Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The term Integrated Systems Health Management (ISHM) is used to describe a capability that focuses on determining the condition (health) of every element in a...

  4. Community health workers and health care delivery: evaluation of a women's reproductive health care project in a developing country.

    Directory of Open Access Journals (Sweden)

    Abdul Wajid

    Full Text Available BACKGROUND: As part of the mid-term evaluation of a Women's Health Care Project, a study was conducted to compare the utilization of maternal and neonatal health (MNH services in two areas with different levels of service in Punjab, Pakistan. METHODS: A cross-sectional survey was conducted to interview Married Women of Reproductive Age (MWRA. Information was collected on MWRA knowledge regarding danger signs during pregnancy, delivery, postnatal periods, and MNH care seeking behavior. After comparing MNH service utilization, the two areas were compared using a logistic regression model, to identify the association of different factors with the intervention after controlling for socio-demographic, economic factors and distance of the MWRA residence to a health care facility. RESULTS: The demographic characteristics of women in the two areas were similar, although socioeconomic status as indicated by level of education and better household amenities, was higher in the intervention area. Consequently, on univariate analysis, utilization of MNH services: antenatal care, TT vaccination, institutional delivery and use of modern contraceptives were higher in the intervention than control area. Nonetheless, multivariable analysis controlling for confounders such as socioeconomic status revealed that utilization of antenatal care services at health centers and TT vaccination during pregnancy are significantly associated with the intervention. CONCLUSIONS: Our findings suggest positive changes in health care seeking behavior of women and families with respect to MNH. Some aspects of care still require attention, such as knowledge about danger signs and neonatal care, especially umbilical cord care. Despite overall success achieved so far in response to the Millennium Development Goals, over the past two decades decreases in maternal mortality are far from the 2015 target. This report identifies some of the key factors to improving MNH and serves as an

  5. A Survey of Practices in Hospital Pharmacies. The UCLA Allied Health Professions Project.

    Science.gov (United States)

    Cullen, Thomas D.; Henrich, Robert R.

    A survey was conducted as part of the UCLA Allied Health Professions Project to determine what procedures are used in health care facility pharmacies for the performance of tasks previously selected for inclusion in a proposed curriculum for pharmacy technicians. Questionnaires were distributed to a national sample of 48 health care facilities,…

  6. The Coronary Health Improvement Projects Impact on Lowering Eating, Sleep, Stress, and Depressive Disorders

    Science.gov (United States)

    Merrill, Ray M.; Aldana, Stephen G.; Greenlaw, Roger L.; Diehl, Hans A.

    2008-01-01

    Background: The Coronary Health Improvement Project (CHIP) is designed to lower cardiovascular risk factors among a group of generally healthy individuals through health education. Purpose: This study will evaluate the efficacy of the CHIP intervention at improving eating, sleep, stress, and depressive disorders. Methods: A health education…

  7. Strengthening rural Latinos' civic engagement for health: The Voceros de Salud project.

    Science.gov (United States)

    López-Cevallos, Daniel; Dierwechter, Tatiana; Volkmann, Kelly; Patton-López, Megan

    2013-11-01

    This article describes the Latino Health Ambassadors Network (Voceros de Salud ) project created to support and mobilize Latino community leaders to address health inequalities in a rural Oregon county. Voceros de Salud is discussed as a model that other rural communities may implement towards strengthening Latino civic engagement for health.

  8. "Does Hope Change? Testing a Project-Based Health Intervention among Urban Students of Color"

    Science.gov (United States)

    Zusevics, Kaija L.; Johnson, Sheri

    2014-01-01

    Hope is positively correlated with educational attainment and health. Interventions based on project-based learning (PBL) may increase youth hope. This study examined how a PBL intervention affected hope among urban students of color. Students in health classes were invited to participate. A PBL health class was implemented in four classrooms. The…

  9. Impact of CYP2C8*3 on paclitaxel clearance in ovarian cancer patients

    DEFF Research Database (Denmark)

    Bergmann, Troels Korshøj; Vach, Werner; Gréen, Henrik;

    be partly responsible for this variation. Paclitaxel is mainly metabolized by CYP2C8; SNPs have been investigated in this context before but conclusions are still lacking. We present a prospective study of paclitaxel clearance (CL) in 93 Caucasian females with epithelial ovarian cancer with regard......Background Toxicity and therapeutic effects of paclitaxel vary greatly between patients and remain a clinically relevant problem with regard to the handling of dose delay/reduction or termination of treatment. We investigated the notion that single nucleotide polymorphisms (SNPs) in CYP2C8 could...... to the CYP2C8 *1b, *1c, *3 and *4 genotypes. Material and methods All patients were diagnosed with primary ovarian/peritoneal cancer and received 175mg/m2 paclitaxel over 3 hrs plus carboplatin (AUC5-6) q3w. All patients gave written and verbal consent. The study was approved by ethics committees in Denmark...

  10. Using WikiProjects to measure the health of Wikipedia

    OpenAIRE

    Tinati, Ramine; Luczak-Rösch, Markus; Hall, Wendy; Shadbolt, Nigel

    2015-01-01

    In this paper we examine WikiProjects, an emergent, community driven feature of Wikipedia. We analysed 3.2 million Wikipedia articles associated with 618 active Wikipedia projects. The dataset contained the logs of over 115 million article revisions and 15 million talk entries both representing the activity of 15 million unique Wikipedians altogether. Our analysis revealed that per WikiProject, the number of article and talk contributions are increasing, as are the number...

  11. Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro.

    Science.gov (United States)

    Yu, Lushan; Shi, Da; Ma, Liping; Zhou, Quan; Zeng, Su

    2013-07-01

    CYP2C8 plays an important role in the metabolism of various drugs, such as paclitaxel, repaglinide and ibuprofen. Polymorphisms in the CYP2C8 gene were shown to influence interindividual differences in the pharmacokinetics of paclitaxel, repaglinide and ibuprofen enantiomers. In this study, three CYP2C8 allelic variants (CYP2C8.2, CYP2C8.3 and CYP2C8.4) and wild-type CYP2C8 (CYP2C8.1) were co-expressed for the first time with human cytochrome P450 oxidoreductase (POR) and cytochrome b5 by using a baculovirus-assisted insect cell expression system. Further, the effects of genotype-phenotype correlations of CYP2C8 alleles on the metabolism of paclitaxel, repaglinide and ibuprofen enantiomers were evaluated. The CLint values of CYP2C8.2, CYP2C8.3 and CYP2C8.4 for paclitaxel were 47.7%, 64.3% and 30.2% of that of CYP2C8.1 (pibuprofen and S-ibuprofen, respectively. Comparing hydroxylation by CYP2C8.1 and CYP2C8.3 resulted in higher and lower intrinsic clearance of repaglinide and ibuprofen enantiomers, respectively. These in vitro findings were consistent with the pharmacokinetics in volunteers who were heterozygous or homozygous carriers of CYP2C8*3. The results of this study provide useful information for predicting CYP2C8 phenotypes and may contribute to individualized drug therapy in the future.

  12. Impact of CYP2C8*3 on paclitaxel clearance

    DEFF Research Database (Denmark)

    Bergmann, T K; Brasch-Andersen, C; Gréen, H;

    2011-01-01

    The primary purpose of this study was to evaluate the effect of CYP2C8*3 and three genetic ABCB1 variants on the elimination of paclitaxel. We studied 93 Caucasian women with ovarian cancer treated with paclitaxel and carboplatin. Using sparse sampling and nonlinear mixed effects modeling, the in...... associations found for CYP2C8*4 (P=0.04) and ABCC1 g.7356253C>G (P=0.04).The Pharmacogenomics Journal advance online publication, 6 April 2010; doi:10.1038/tpj.2010.19....

  13. Implementation of municipal health promoting projects in primary schools: teachers perspective

    DEFF Research Database (Denmark)

    Nordin, Lone Lindegard

    2013-01-01

    ' convert the politically determined objectives in in relation to diet, physical activity and action competence to practice in health education? • How to understand teachers' practices in relation to the policy objectives set out from their stories of individual and institutional factors? Methodology......Implementation of municipally health promoting projects' in primary schools: teachers perspective Research question This paper discusses the findings from a qualitative research, that aimed to investigate how teachers in primary schools implemented municipal health promoting projects focusing...... on diet and physically activity, and how factors related to individual and institutional factors, according to the teachers, affected the implementation process. The research is linked to a health-promotion intervention project The School Health Project in a Danish municipality in the province...

  14. Diagnostic framework and health check tool for engineering and technology projects

    Directory of Open Access Journals (Sweden)

    Simon P Philbin

    2014-10-01

    Full Text Available Purpose: Development of a practitioner oriented diagnostic framework and health check tool to support the robust assessment of engineering and technology projects.Design/methodology/approach: The research is based on a literature review that draws together insights on project assessment and critical success factors to establish an integrated systems view of projects. This is extended to allow a comprehensive diagnostic framework to be developed along with a high-level health check tool that can be readily deployed on projects. The utility of the diagnostic framework and health check tool are explored through three illustrative case studies, with two from Canada and one from the United Kingdom. Findings andOriginality/value: The performance of engineering and technology projects can be viewed through a systems perspective and being a function of six sub-systems that are: process, technology, resources, impact, knowledge and culture. The diagnostic framework that is developed through this research integrates these sub-systems to provide a comprehensive assessment methodology for projects, which is linked to existing best practice for project reviews, performance management and maturity models. The case studies provide managerial insights that are related to the diagnostic framework but crucially also position the approach in the context of industrial applications for construction engineering and technology management.Research limitations/implications: The case study approach includes two case studies from the construction and facilities development sector with the third case study from the research and technology sector. Further work is required to investigate the use of the diagnostic framework and health check tool in other sectors.Practical implications: The health check tool will be of practical benefit to new projects managers that require access to a robust and convenient project review methodology for assessing the status and health of a

  15. Health-promoting residential aged care: a pilot project in Austria.

    Science.gov (United States)

    Krajic, Karl; Cichocki, Martin; Quehenberger, Viktoria

    2015-09-01

    Long-term care for the aged is an area that has not been in the focus of health promotion so far. The paper describes context, concept and project plan of a 2-year pilot project of comprehensive health-promoting setting development in residential aged care in Austria, and provides an overview over main experiences and results. Austria's most relevant health promotion agencies, a specialized scientific institute and Austria's largest provider of aged care acted as partners. The project aimed at developing elements of a comprehensive approach, but also providing evidence for the effectiveness of health promotion. Therefore, the project combined an organizational development approach with a scientific, randomized controlled study on mobility enhancement for residents. A comprehensive settings approach turned out acceptable for the main stakeholders of aged care (owners and management, staff, residents and residents' relatives). Strategy development, based on a systematic needs assessment, found staff health to be of special interest for the organization (ergonomics, workability over life course), and residents' relatives, got more attention. The mobility study was able to achieve positive results on occupational performance, concerning quality-of-life indicators and reached also formerly inactive groups. After the end of the project, health promotion is still on the agenda of the organization; further developments will be monitored. Good support from the policy level and well-established networking between the aged care provider, health promotion agencies and a network for health promotion in health care seems to have been an important resource for success.

  16. Immigration, health and diversity management: Preliminary developments of a project in neighborhoods of Catalonia

    Directory of Open Access Journals (Sweden)

    Dan Rodríguez-García

    2007-09-01

    Full Text Available This article presents an ongoing research project on immigration, health, and socio-cultural diversity, and offers preliminary information on the theoretical and socio-demographic context of this investigation. The objective of the project, funded by the Department of Health of the Autonomous Government of Catalonia, Spain, is to analyse the socioeconomic and cultural factors involved in health and the access to the formal health system of a few major migrant communities and ethnic minorities living in high-priority neighbourhoods in Catalonia. The results of this project, which will come fundamentally from ethnographic research, aim to give suggestions for improving health conditions for the population and to provide to those professionals working in the public health care system with some conceptual and practical tools for improving intercultural communication between themselves and their patients, as well as for detecting, preventing, and resolving problems in everyday practice.

  17. Projections of national health expenditures through the year 2000

    OpenAIRE

    Sonnefeld, Sally T.; Waldo, Daniel R.; Lemieux, Jeffrey A.; McKusick, David R.

    1991-01-01

    In this article, the authors present a scenario for health expenditures during the 1990s. Assuming that current laws and practices remain unchanged, the Nation will spend $1.6 trillion for health care in the year 2000, an amount equal to 16.4 percent of that year's gross national product. Medicare and Medicaid will foot an increasing share of the Nation's health bill, rising to more than one-third of the total. The factors accounting for growth in national health spending are described as wel...

  18. 75 FR 8796 - Civil Penalties Under ERISA Section 502(c)(8)

    Science.gov (United States)

    2010-02-26

    ... model notice for plans in critical status. See 73 FR 15688 (Mar. 25, 2008). However, section 102(b)(1)(C...\\ Pursuant to Reorganization Plan No. 4 of 1978, 43 FR 47713 (Oct. 17, 1978), the Department of the Treasury... regulation, to be codified at 29 CFR 2560.502c-8, without change. \\6\\ 74 FR 45791. B. Overview of Final...

  19. Data-intensive structural health monitoring in the infrawatch project

    OpenAIRE

    Veerman, R.P.; Miao, S.; Koenders, E.A.B.; Knobbe, A.

    2013-01-01

    The InfraWatch project is a Dutch research project, aimed at developing novel techniques for large-scale monitoring of concrete infra-structures. The project involves a large bridge, fitted with multiple types of sensors that capture the high-resolution dynamic behavior of the bridge. With 145 sensors measuring at 100 Hz, a huge amount of data becomes available that describes various aspects of the bridge’s response to traffic and weather conditions, both long and short-term. A single truck p...

  20. The impact of CYP2C8 polymorphism and grapefruit juice on the pharmacokinetics of repaglinide

    Science.gov (United States)

    Bidstrup, Tanja Busk; Damkier, Per; Olsen, Anette Kristensen; Ekblom, Marianne; Karlsson, Anders; Brøsen, Kim

    2006-01-01

    Aims The primary aim of the study was to investigate the possible effect of the CYP2C8 3 allele and of grapefruit juice on the pharmacokinetics of repaglinide. Furthermore, the impact of a single dose of grapefruit juice on the pharmacokinetics of repaglinide in relation to dose. Methods Thirty-six healthy male subjects, genotyped for CYP2C8 3 (11 genotyped as CYP2C8 1/ 3, one as CYP2C8 3/ 3 and 24 as CYP2C8 1/ 1), participated in a randomized, cross-over trial. In the two phases, the subjects drank 300 mL water or 300 mL grapefruit juice, in randomized order, 2 h before administration of a single dose of either 0.25 mg or 2 mg repaglinide. Results Neither the mean AUC0−∞ (geometric mean ratio: 1.01; 95% CI: 0.93–1.1, P = 0.88) nor the mean Cmax (geometric mean ratio: 1.05; 95% CI: 0.94–1.2, P = 0.35) of repaglinide were statistically significantly different in the group carrying the CYP2C8 3 mutant allele compared with wild-types. Grapefruit juice caused a 19% decrease in the geometric mean ratio of the 3-hydroxyquinidine to quinidine ratio (difference: 0.81; 95% CI: 0.75–0.87, P < 0.0001), which was used as an index of CYP3A4 activity, and an increase in the mean AUC0−∞ of repaglinide (geometric mean ratio: 1.13; 95% CI: 1.04–1.2, P = 0.0048), but had no statistically significant effect on the t1/2. There was no statistically significant difference in blood glucose concentration in subjects who had or had not ingested grapefruit juice. The effect was more pronounced at the low dose of repaglinide (0.25 mg) than at the therapeutic dose of 2 mg. Conclusions The pharmacokinetics of repaglinide in subjects carrying the CYP2C8*3 mutant allele did not differ significantly from those in the wild-types. Grapefruit juice increased the bioavailability of repaglinide, suggesting significant intestinal elimination of the drug which was assumed to be primarily mediated by CYP3A4 in the gut. PMID:16390351

  1. Survival of the project: a case study of ICT innovation in health care.

    Science.gov (United States)

    Andreassen, Hege K; Kjekshus, Lars Erik; Tjora, Aksel

    2015-05-01

    From twenty years of information and communication technology (ICT) projects in the health sector, we have learned one thing: most projects remain projects. The problem of pilotism in e-health and telemedicine is a growing concern, both in medical literature and among policy makers, who now ask for large-scale implementation of ICT in routine health service delivery. In this article, we turn the question of failing projects upside down. Instead of investigating the obstacles to implementing ICT and realising permanent changes in health care routines, we ask what makes the temporary ICT project survive, despite an apparent lack of success. Our empirical material is based on Norwegian telemedicine. Through a case study, we take an in-depth look into the history of one particular telemedical initiative and highlight how ICT projects matter on a managerial level. Our analysis reveals how management tasks were delegated to the ICT project, which thus contributed to four processes of organisational control: allocating resources, generating and managing enthusiasm, system correction and aligning local practice and national policies. We argue that the innovation project in itself can be considered an innovation that has become normalised in health care, not in clinical, but in management work. In everyday management, the ICT project appears to be a convenient tool suited to ease the tensions between state regulatory practices and claims of professional autonomy that arise in the wake of new public management reforms. Separating project management and funding from routine practice handles the conceptualised heterogeneity between innovation and routine within contemporary health care delivery. Whilst this separation eases the execution of both normal routines and innovative projects, it also delays expected diffusion of technology. PMID:25795426

  2. Survival of the project: a case study of ICT innovation in health care.

    Science.gov (United States)

    Andreassen, Hege K; Kjekshus, Lars Erik; Tjora, Aksel

    2015-05-01

    From twenty years of information and communication technology (ICT) projects in the health sector, we have learned one thing: most projects remain projects. The problem of pilotism in e-health and telemedicine is a growing concern, both in medical literature and among policy makers, who now ask for large-scale implementation of ICT in routine health service delivery. In this article, we turn the question of failing projects upside down. Instead of investigating the obstacles to implementing ICT and realising permanent changes in health care routines, we ask what makes the temporary ICT project survive, despite an apparent lack of success. Our empirical material is based on Norwegian telemedicine. Through a case study, we take an in-depth look into the history of one particular telemedical initiative and highlight how ICT projects matter on a managerial level. Our analysis reveals how management tasks were delegated to the ICT project, which thus contributed to four processes of organisational control: allocating resources, generating and managing enthusiasm, system correction and aligning local practice and national policies. We argue that the innovation project in itself can be considered an innovation that has become normalised in health care, not in clinical, but in management work. In everyday management, the ICT project appears to be a convenient tool suited to ease the tensions between state regulatory practices and claims of professional autonomy that arise in the wake of new public management reforms. Separating project management and funding from routine practice handles the conceptualised heterogeneity between innovation and routine within contemporary health care delivery. Whilst this separation eases the execution of both normal routines and innovative projects, it also delays expected diffusion of technology.

  3. Overview of recent trans-institutional health network projects in Japan and Germany.

    Science.gov (United States)

    Juhr, Maren; Haux, Reinhold; Suzuki, Takahiro; Takabayashi, Katsuhiko

    2015-05-01

    Worldwide populations are aging and countries have to prepare for the effects of demographic change in health care. Health information exchange (HIE), which is the process of moving patient information across health care providers electronically, can help overcome health data fragmentation and open opportunities to improve patient care in terms of quality, economy and efficiency. Since Japan and Germany are among the first countries strongly impacted by demographic changes of aging populations, we report on current developments about health information systems carrying out HIE based on case studies in both countries. Four projects that address the improvement of HIE within a defined region have been selected and investigated: the German project of the Lower Saxony Bank of Health and the Japanese projects Chiba ITnet, Nagasaki AjisaiNet and the National Disaster and Backup System of Japan. The project descriptions are based on relevant English publications, on-site visits and interviews with developers and users. The projects are introduced in terms of their basic architecture and implementation, their present status and future objectives. The projects' developments are still in progress and all have to cope with significant challenges before they will be able to provide a fully working trans-institutional health network solution. PMID:25732082

  4. Avatar Robot for Crew Performance and Behavioral Health Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This project investigates the effectiveness of using an avatar robotic platform as a crew assistant and a family member substitute. This type of avatar robot is...

  5. Quantifiable and Reliable Structural Health Management Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Under Project Constellation, NASA is developing a new generation of spacecraft for human spaceflight. A significant percentage of the structures used in these...

  6. Aircraft Electrical Power System Diagnostics and Health Management Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of the project is the development of an open architecture, computational toolbox for design and implementation of diagnostic and prognostic algorithms...

  7. Advanced Data Mining and Deployment for Integrated Vehicle Health Management and the Space Vehicle Lifecycle Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In a successful Phase 1 project for NASA SBIR topic A1.05, "Data Mining for Integrated Vehicle Health Management," Michigan Aerospace Corporation (MAC) demonstrated...

  8. Onboard Space Autonomy Through Integration of Health Management and Control Reconfiguration Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this SBIR project we propose to integrate spacecraft control and vehicle health functions to improve the robustness and productivity of space operations. The...

  9. Data Analysis Algorithm Suitable for Structural Health Monitoring Based on Dust Network Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposed project will attempt to develop a data analysis system for structural health monitoring on space structures. The data analysis software will be a key...

  10. On-Orbit Health Monitoring and Repair Assessment of Thermal Protection Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR project delivers On-orbit health MoNItoring and repair assessment of THERMal protection systems (OMNI_THERM). OMNI_THERM features impedance-based...

  11. Autonomus I&C Maintenance and Health Monitoring System for Fission Surface Power Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The primary goal of this project is to design and develop an autonomous instrumentation and control (I&C) health monitoring system for space nuclear power...

  12. Wireless Health Monitoring for Large Arrays of MEMS Sensors and Actuators Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of this Phase I project is to demonstrate an automated on-line structural health monitoring system for aircraft structures using a combination of...

  13. Weight Care Project: Health professionals' attitudes and ability to assess body weight status - Study protocol

    LENUS (Irish Health Repository)

    Moorhead, Anne

    2011-03-31

    Abstract Background Health professionals working in primary care and public health have opportunities to address body weight status issues with their patients through face-to-face contact. The objectives of this all-Ireland project are: 1. to assess the attitudes, current practices\\/behaviours and knowledge of key health professional groups on body weight status; 2. to assess the health professional groups\\' ability to identify body weight status in both adults and children. The health professional groups are: (a) community related public health nurses; (b) school public health nurses; (c) GPs and practice nurses (primary care); and (d) occupational health nurses (workplace) from both Northern Ireland and the Republic of Ireland. Methods\\/Design This all-Ireland multi-disciplinary project follows a mixed methods approach using both quantitative and qualitative methodologies, and consists of four components: 1. Literature review - to explore the role of health professionals in managing obesity through spontaneous intervention in a variety of health promotion settings. 2. Telephone interviews and focus groups - to gain an in-depth insight into the views of health professionals in assessing body weight status. 3. Survey (primarily online but also paper-based) - to determine the attitudes, current practices\\/behaviours and knowledge of health professionals in assessing body weight status. 4. Online evaluation study - an online interactive programme will be developed to assess health professionals\\' ability to identify the body weight status of adults and children. Discussion This project will assess and report the attitudes, current practices\\/behaviours and knowledge of key health professional groups within Northern Ireland and the Republic of Ireland on body weight status, and their ability to identify body weight status in both adults and children. The results of this project will generate recommendations for clinical practice in managing obesity, which may

  14. Weight Care Project: Health professionals' attitudes and ability to assess body weight status - Study protocol

    Directory of Open Access Journals (Sweden)

    Murphy Kathy

    2011-03-01

    Full Text Available Abstract Background Health professionals working in primary care and public health have opportunities to address body weight status issues with their patients through face-to-face contact. The objectives of this all-Ireland project are: 1. to assess the attitudes, current practices/behaviours and knowledge of key health professional groups on body weight status; 2. to assess the health professional groups' ability to identify body weight status in both adults and children. The health professional groups are: (a community related public health nurses; (b school public health nurses; (c GPs and practice nurses (primary care; and (d occupational health nurses (workplace from both Northern Ireland and the Republic of Ireland. Methods/Design This all-Ireland multi-disciplinary project follows a mixed methods approach using both quantitative and qualitative methodologies, and consists of four components: 1. Literature review - to explore the role of health professionals in managing obesity through spontaneous intervention in a variety of health promotion settings. 2. Telephone interviews and focus groups - to gain an in-depth insight into the views of health professionals in assessing body weight status. 3. Survey (primarily online but also paper-based - to determine the attitudes, current practices/behaviours and knowledge of health professionals in assessing body weight status. 4. Online evaluation study - an online interactive programme will be developed to assess health professionals' ability to identify the body weight status of adults and children. Discussion This project will assess and report the attitudes, current practices/behaviours and knowledge of key health professional groups within Northern Ireland and the Republic of Ireland on body weight status, and their ability to identify body weight status in both adults and children. The results of this project will generate recommendations for clinical practice in managing obesity, which may

  15. All-Fiber-Optic Ultrasonic Health Management System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Health management of composite airframe components is essential for safety and reliability of future aircrafts. It reduces the risk of catastrophic failures and...

  16. Distributed Rocket Engine Testing Health Monitoring System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The on-ground and Distributed Rocket Engine Testing Health Monitoring System (DiRETHMS) provides a system architecture and software tools for performing diagnostics...

  17. Distributed Rocket Engine Testing Health Monitoring System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Leveraging the Phase I achievements of the Distributed Rocket Engine Testing Health Monitoring System (DiRETHMS) including its software toolsets and system building...

  18. Quantifiable and Reliable Structural Health Management Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Major concerns for implementing a practical built-in structural health monitoring system are prediction accuracy and data reliability. It is proposed to develop...

  19. Passive Wireless Sensor System for Structural Health Monitoring Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Albido proposes to develop a Passive Wireless Sensor System for Structural Health Monitoring capable of measuring high-bandwidth temperature and strain of space and...

  20. Aircraft Control Augmentation and Health Monitoring Using FADS Technology Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I research proposal is aimed at demonstrating the feasibility of an innovative architecture comprising control augmentation and on-line health monitoring...

  1. Sensor Area Network for Integrated Systems Health Management Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The term Integrated Systems Health Management (ISHM) is used to describe a capability that focuses on determining the condition of every element in a complex System...

  2. Integrated Health Management for Space Flight Digital Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposal addresses the need for a real-time Prognostics and Health Management (PHM) system to identify anomalous states in digital electronic systems used in...

  3. Self-Assembled Nanostructured Health Monitoring Sensors Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of the proposed NASA SBIR program is to design, fabricate and evaluate the performance of self-assembled nanostructured sensors for the health...

  4. European project HOPE (Health Optimization Protocol for Energy-efficient Buildings)

    NARCIS (Netherlands)

    Bluyssen, P.M.; Cox, C.W.J.; Maroni, M.; Boschi, N.; Raw, G.; Roulet, C.A.; Foradini, F.

    2003-01-01

    In January 2002, a new European project named HOPE (Health Optimization Protocol for Energy-efficient Buildings) started with 14 participants from nine European countries. The final goal of the project is to provide the means to increase the number of energy-efficient buildings, i.e. buildings that

  5. Raziskava o zagotavljanju kakovosti v slovenskem osnovnem zdravstvu = Primary health care quality management project.

    NARCIS (Netherlands)

    Bulc, M.; Kersnik, J.; Boerma, W.; Pellny, M.

    2009-01-01

    Background: The article summarizes the main results of the WHO Primary Care Quality Management project, which has been implemented as a pilot study to identify and support mechanisms for quality management in primary health care. Material and methods: The project was commissioned by WHO Europe and c

  6. Parent Partnerships Project for Children's Mental Health Training for Professionals. PHP-c87

    Science.gov (United States)

    PACER Center, 2004

    2004-01-01

    In the fall of 2003, PACER Center's Parent Partnership Project for Children's Mental Health conducted a survey to better understand what parents and families need from the children?s mental health system in Minnesota. The research team developed a survey questionnaire, a telephone interview, and a focus group session directed at learning what was…

  7. Parent Partnerships Project for Children's Mental Health "Access to Services." PHP-c88

    Science.gov (United States)

    PACER Center, 2004

    2004-01-01

    In the fall of 2003, PACER Center's Parent Partnership Project for Children's Mental Health conducted a survey to better understand what parents and families need from the children's mental health system in Minnesota. The research team developed a survey questionnaire, a telephone interview, and a focus group session directed at learning what was…

  8. Parent Partnerships Project for Children's Mental Health "The Commitment of Financial Resources." PHP-c89

    Science.gov (United States)

    PACER Center, 2004

    2004-01-01

    In the fall of 2003, PACER Center's Parent Partnership Project for Children's Mental Health conducted a survey to better understand what parents and families need from the children's mental health system in Minnesota. The research team developed a survey questionnaire, a telephone interview, and a focus group session directed at learning what was…

  9. Implementation of an ICT-Based Learning Environment in a Nutrition Health Project

    Science.gov (United States)

    Raiha, Teija; Tossavainen, Kerttu; Enkenberg, Jorma; Turunen, Hannele

    2012-01-01

    Purpose: The purpose of this study was to investigate the views of school staff on a nutrition health project implemented via an ICT-based learning environment in a secondary school (7th to 9th grades). Design/methodology/approach: The study was a part of the wider European Network for Health Promoting Schools programme (ENHPS; since 2008, Schools…

  10. Agile informatics: application of agile project management to the development of a personal health application.

    Science.gov (United States)

    Chung, Jeanhee; Pankey, Evan; Norris, Ryan J

    2007-10-11

    We describe the application of the Agile method-- a short iteration cycle, user responsive, measurable software development approach-- to the project management of a modular personal health record, iHealthSpace, to be deployed to the patients and providers of a large academic primary care practice.

  11. Quantifying the health impacts of ambient air pollutants : recommendations of a WHO/Europe project

    NARCIS (Netherlands)

    Héroux, Marie-Eve; Anderson, H Ross; Atkinson, Richard; Brunekreef, Bert; Cohen, Aaron; Forastiere, Francesco; Hurley, Fintan; Katsouyanni, Klea; Krewski, Daniel; Krzyzanowski, Michal; Künzli, Nino; Mills, Inga; Querol, Xavier; Ostro, Bart; Walton, Heather

    2015-01-01

    OBJECTIVE: Quantitative estimates of air pollution health impacts have become an increasingly critical input to policy decisions. The WHO project "Health risks of air pollution in Europe-HRAPIE" was implemented to provide the evidence-based concentration-response functions for quantifying air pollut

  12. Agile informatics: application of agile project management to the development of a personal health application.

    Science.gov (United States)

    Chung, Jeanhee; Pankey, Evan; Norris, Ryan J

    2007-01-01

    We describe the application of the Agile method-- a short iteration cycle, user responsive, measurable software development approach-- to the project management of a modular personal health record, iHealthSpace, to be deployed to the patients and providers of a large academic primary care practice. PMID:18694014

  13. Design, synthesis, and anticancer activity of C8-substituted-4'-thionucleosides as potential HSP90 inhibitors.

    Science.gov (United States)

    Qu, Shuhao; Mulamoottil, Varughese A; Nayak, Akshata; Ryu, Seungyeon; Hou, Xiyan; Song, Jayoung; Yu, Jinha; Sahu, Pramod K; Zhao, Long Xuan; Choi, Sun; Lee, Sang Kook; Jeong, Lak Shin

    2016-08-15

    A series of C8-substituted-4'-thioadenosine analogs 3a-3g, 15, and 17 and their truncated derivatives 4a-4j, 23-25, and 27 have been successfully synthesized from d-ribose and d-mannose, respectively, employing Pummerer type or Vorbrüggen condensation reactions and the functionalization at the C8-position of nucleobase via Stille coupling or nucleophilic aromatic substitution reactions as key steps. All the synthesized compounds were assayed for their HSP90 inhibitory activity, but they were found to be inactive up to 100μM. However, the 8-iodo derivatives 15, 17, and 27 exhibited potent anticancer activity, indicating that different mechanism of action might be involved in their biological activity. PMID:27283788

  14. Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis.

    Science.gov (United States)

    Evans, Iona C; Barnes, Josephine L; Garner, Ian M; Pearce, David R; Maher, Toby M; Shiwen, Xu; Renzoni, Elisabetta A; Wells, Athol U; Denton, Christopher P; Laurent, Geoffrey J; Abraham, David J; McAnulty, Robin J

    2016-04-01

    Fibroblasts derived from the lungs of patients with idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc) produce low levels of prostaglandin (PG) E2, due to a limited capacity to up-regulate cyclooxygenase-2 (COX-2). This deficiency contributes functionally to the fibroproliferative state, however the mechanisms responsible are incompletely understood. In the present study, we examined whether the reduced level of COX-2 mRNA expression observed in fibrotic lung fibroblasts is regulated epigenetically. The DNA methylation inhibitor, 5-aza-2'-deoxycytidine (5AZA) restored COX-2 mRNA expression by fibrotic lung fibroblasts dose dependently. Functionally, this resulted in normalization of fibroblast phenotype in terms of PGE2 production, collagen mRNA expression and sensitivity to apoptosis. COX-2 methylation assessed by bisulfite sequencing and methylation microarrays was not different in fibrotic fibroblasts compared with controls. However, further analysis of the methylation array data identified a transcriptional regulator, chromosome 8 open reading frame 4 (thyroid cancer protein 1, TC-1) (c8orf4), which is hypermethylated and down-regulated in fibrotic fibroblasts compared with controls. siRNA knockdown of c8orf4 in control fibroblasts down-regulated COX-2 and PGE2 production generating a phenotype similar to that observed in fibrotic lung fibroblasts. Chromatin immunoprecipitation demonstrated that c8orf4 regulates COX-2 expression in lung fibroblasts through binding of the proximal promoter. We conclude that the decreased capacity of fibrotic lung fibroblasts to up-regulate COX-2 expression and COX-2-derived PGE2 synthesis is due to an indirect epigenetic mechanism involving hypermethylation of the transcriptional regulator, c8orf4.

  15. Public health response to radiation emergencies and the role of the Helsinki Project Office

    International Nuclear Information System (INIS)

    This paper focuses on the public health element of nuclear emergency preparedness, defined as the mitigation of the long-term effects of radiation on exposed populations, as opposed to dealing with the health consequences of an exposure in an individual (termed medical aspects). The paper also approaches to the role of the Helsinki Project Office which is concerned with the protection of public health through effective response to nuclear emergencies, and falling into two categories, namely contingency planning or preparedness, and response

  16. Empowering patients through eHealth: a case report of a pan-European project

    OpenAIRE

    Lettieri, Emanuele; Fumagalli, Lia P.; Radaelli, Giovanni; Bertele’, Paolo; Vogt, Jess; Hammerschmidt, Reinhard; Lara, Juan L.; Carriazo, Ana; Masella, Cristina

    2015-01-01

    Background This paper crystallises the experience developed by the pan-European PALANTE Consortium in dealing with the generation of relevant evidence from heterogeneous eHealth services for patient empowerment in nine European Regions. The European Commission (EC) recently funded a number of pan-European eHealth projects aimed at empowering European patients/citizens thus transforming the traditional patient/citizen role in the management of their health (e.g., PALANTE, SUSTAIN, CARRE, Heart...

  17. The Fresno County Refugee Health Volunteer Project: a case study in cross-cultural health care delivery.

    Science.gov (United States)

    Rowe, D R; Spees, H P

    1987-01-01

    Beginning in 1979, Fresno County received a 2nd dramatic influx of Southeast Asian refugees. There are now approximately 20,000 of these refugees, including the largest population of Hmong in the US. This community includes about 2000 Cambodian, 14,000 Hmong, and 4000 Lowland Lao. Altogether, Southeast Asian refugees comprise nearly 10% of the population of Fresno. These demographics provide the backdrop for significant problems in health care service delivery. Some barriers include: 1) stress, loss, dislocation, poverty, illness, and unemployment that are part of the refugee experience; 2) language differences; 3) cultural isolation; and 4) cultural beliefs and practices whose spiritual, wholistic, and natural forms of care often run contrary to the West's scientific, specialized, and technological treatment modalities. The Health Department began to recognize some difficulties related to health services for refugees and developed a strategy to combat these. This strategy was named the Refugee Health Volunteer Project and its goal was to enable individuals, families, and community groups to better meet their own health care needs. Goals were to be met by 1st creating a community-based health promotion network to 1) identify health needs, 2) communicate health information, 3) train community health volunteers, and 4) build a greater capacity for self-care that would last beyond the end of the program. The program's goal would also be met by overcoming the access problems with the service system by 1) communicating community-identified needs, 2) identifying specific barriers in the service system, 3) initiating broad participation among service providers in designing more accessible approaches to service delivery, and 4) improving coordination between service providers. Significant progress has been made in a very short time. The Project demonstrates that a fairly common, bureaucratic organization can be responsive to extremely unique community needs. The project is

  18. Incorporation of occupational health and safety in cleaner production projects in South Africa

    DEFF Research Database (Denmark)

    Hedlund, Frank Huess

    2002-01-01

    The purpose of this research is to reveal ways in which occupational health and safety can be integrated in environmental cleaner production projects. Of particular interest are those cleaner production projects that are run by the Danish government's environmental assistance agency, Danced......, in South Africa.The study explores two main avenues of integration. First, integrating through better planning, focussing at the tools and procedures in use by Danced for project management -- integrating occupational health and safety into the project specification, so to speak.Second, integrating...... occupational health and safety into the environmental activities that take place at company level. Two ways of doing so are explored, the main distinction being company size. For large companies, integration of management systems may be attractive. For small companies, integration into a less formal network...

  19. Insights from the Health OER Inter-Institutional Project

    Science.gov (United States)

    Harley, Ken

    2011-01-01

    Open educational resources (OER) are gaining ascendancy in education, particularly in higher education. Logic suggests that the potential benefits of OER are likely to be greatest in resource-poor contexts such as Africa. However, little is known about the feasibility and sustainability of their use in African institutions. In the Health OER…

  20. Why are there defaulters in eye health projects?

    Directory of Open Access Journals (Sweden)

    Regina Noma

    2011-01-01

    Full Text Available PURPOSE: To identify barriers to attendance for eye examination of schoolchildren. METHODS: Cross-sectional study. Students in grades 1-4 in elementary school in Guarulhos (Brazil were screened and referred for ophthalmic examination in 2006. Facilities offered in this project were: examination arranged during weekends, free transportation, spectacle donation and two different opportunities for exam. A questionnaire was applied, by interview, to a sample consisted of students' parents attended in a community project who missed the first call and attended the recall, to identify the reasons for non-attendance. RESULTS: The sample consisted of 767 parents or guardians, corresponding to an equal number of schoolchildren. Personal characteristics of the students: 49.2% male and 50.8% female, 60.2% of them had never received previous ophthalmologic evaluation. Reported reasons for no-show to the project: parents had not received appropriate orientation (35.6%, loss of working day (20.6%, illness (12.4%, had another appointment (10.0%. The need for eyeglasses was higher in the recall. CONCLUSIONS: A significant number of parents did not take their children for ophthalmological exams, even when a second opportunity was offered in projects with transportation facilities, free exams performed during weekends and spectacle donation. The main causes of absenteeism were lack of awareness and work. For 87.1% of the absenteeism cases, the difficulties could be overcome via improved structuring of the first call. A recall increases attendance coverage of target population by only 15.2% (59.3 to 74.5%. Notably, the eye exam campaign was the first exam for most of the absent students.

  1. Why are there defaulters in eye health projects?

    OpenAIRE

    Regina Noma; Regina de S Carvalho; Newton Kara José

    2011-01-01

    PURPOSE: To identify barriers to attendance for eye examination of schoolchildren. METHODS: Cross-sectional study. Students in grades 1-4 in elementary school in Guarulhos (Brazil) were screened and referred for ophthalmic examination in 2006. Facilities offered in this project were: examination arranged during weekends, free transportation, spectacle donation and two different opportunities for exam. A questionnaire was applied, by interview, to a sample consisted of students' parents attend...

  2. The demonstration projects: creating the capacity for nursing health human resource planning in Ontario's healthcare organizations.

    Science.gov (United States)

    Burkoski, Vanessa; Tepper, Joshua

    2010-05-01

    Timely access to healthcare services requires the right number, mix and distribution of appropriately educated nurses, physicians and other healthcare professionals. In Ontario, as in several other jurisdictions, changing demographics, patterns of health service utilization and an aging workforce have created challenges related to the supply of nurses available now and in the future to deliver quality patient care. From 2006 to 2009, the Nursing Secretariat (NS) of Ontario's Ministry of Health and Long-Term Care (the ministry) undertook a progressive and comprehensive approach to address the issue of nursing supply across the province through the introduction of 17 Nursing Health Human Resources Demonstration Projects (demonstration projects). The demonstration projects initiative has led to the creation of a unique collection of best practices, tools and resources aimed at improving organizational planning capacity. Evaluation of the initiative generated recommendations that may guide the ministry toward policy and program development to foster improved nursing health human resource planning capacity in Ontario healthcare organizations.

  3. A methodological and operative framework for the evaluation of an e-health project.

    Science.gov (United States)

    Buccoliero, Luca; Calciolari, Stefano; Marsilio, Marta

    2008-01-01

    Assessing public sector ICT investments represents the premise for successful implementation of an e-health strategy. The recent literature stresses the importance of going beyond the mere financial and/or technical dimensions of the analysis. Consequently, the paper proposes an example of e-health project evaluation aiming to develop measures which get close to the notion of benefits to the different stakeholders involved: top management, patients, local community. The case study refers to an Italian health care organization that implemented a project of digitalization of its clinical reports production few years ago. Based on on-field research, different approaches are used to assess costs and benefits from different stakeholders' perspectives. The results of a multidimensional evaluation are reported to emphasize the need for different measures to assess the sustainability of an e-health project according to the financial convenience, the social role of the organization, and the contingent situation.

  4. Molecular Characterization and Expression Analyses of the Complement Component C8α, C8β and C9 Genes in Yellow Catfish (Pelteobagrus fulvidraco after the Aeromonas hydrophila Challenge

    Directory of Open Access Journals (Sweden)

    Huan Zheng

    2016-03-01

    Full Text Available The complement components C8α, C8β and C9 have important roles in the innate immune system against invading microorganisms. Partial cDNA sequences of the Pf_C8α, Pf_C8β and Pf_C9 genes (Pf: abbreviation of Pelteobagrus fulvidraco were cloned from yellow catfish. The Pf_C8α, Pf_C8β and Pf_C9 genes showed the greatest amino acid similarity to C8α (54% and C8β (62% of zebrafish and to C9 (52% of grass carp, respectively. Ontogenetic expression analyses using real-time quantitative PCR suggested that the three genes may play crucial roles during embryonic and early larval development. The mRNA expressions of the three genes were all at the highest levels in liver tissue, and at lower or much lower levels in 16 other tissues, demonstrating that the liver is the primary site for the protein synthesis of Pf_C8α, Pf_C8β and Pf_C9. Injection of Aeromonas hydrophila led to up-regulation of the three genes in the spleen, head kidney, kidney, liver and blood tissues, indicating that the three genes may contribute to the host’s defense against invading pathogenic microbes. An increased understanding of the functions of the Pf_C8α, Pf_C8β and Pf_C9 genes in the innate immunity of yellow catfish will help enhance production of this valuable freshwater species.

  5. Sustainable Development and Health: Recent International Developments, Policies and Projects

    Institute of Scientific and Technical Information of China (English)

    Liliana Cori

    2006-01-01

    Environment and health have been more and more jointly addressed in recent years, thanks to the efforts of several public and private institutions. In this scenario, a leading role has been played by the World Heath Organisation (WHO). A specific attention was devoted to the issue by the European Union (EU) EU institutions and the WHO Office for Europe, which lists 52 countries (including Europe, Eastern European Countries and Turkey,former Yugoslavia and part of the former Soviet Union). The objectives of the present paper are to give an overview of the main developments in this area, and to underline the progress made towards a common understanding of health and environment issues, the advantages and limits of these developments and the challenges for the future, to be tackled at a global level.

  6. National health expenditure projections, 2013-23: faster growth expected with expanded coverage and improving economy.

    Science.gov (United States)

    Sisko, Andrea M; Keehan, Sean P; Cuckler, Gigi A; Madison, Andrew J; Smith, Sheila D; Wolfe, Christian J; Stone, Devin A; Lizonitz, Joseph M; Poisal, John A

    2014-10-01

    In 2013 health spending growth is expected to have remained slow, at 3.6 percent, as a result of the sluggish economic recovery, the effects of sequestration, and continued increases in private health insurance cost-sharing requirements. The combined effects of the Affordable Care Act's coverage expansions, faster economic growth, and population aging are expected to fuel health spending growth this year and thereafter (5.6 percent in 2014 and 6.0 percent per year for 2015-23). However, the average rate of increase through 2023 is projected to be slower than the 7.2 percent average growth experienced during 1990-2008. Because health spending is projected to grow 1.1 percentage points faster than the average economic growth during 2013-23, the health share of the gross domestic product is expected to rise from 17.2 percent in 2012 to 19.3 percent in 2023.

  7. Synthesis and glycosidase inhibitory activity of new hexa-substituted C8-glycomimetics

    Directory of Open Access Journals (Sweden)

    Prangé Thierry

    2005-10-01

    Full Text Available Text abstract Background Glycosidases are involved in several metabolic pathways and the development of inhibitors is an important challenge towards the treatment of diseases, such as diabetes, cancer and viral infections including AIDS. Thus, inhibition of intestinal α-glucosidases can be used to treat diabetes through the lowering of blood glucose levels, and α-glucosidase inhibitors are being marketed against type 2 (non-insulinodependent mellitus diabetes (i.e.: Glyset® or Diastabol®, Basen® and Glucor® or Precose®. Results In that context, new C8-carbasugars and related aminocyclitols have been targeted in order to study the effect of the enhanced flexibility and of the new spatial distribution displayed by these structures on their adaptability in the active site of the enzymes. The synthesis of these new C8-glycomimetics is described from enantiomerically pure C2-symmetrical polyhydroxylated cyclooctenes. Their obtention notably involved a syn-dihydroxylation, and more extended functionalization through formation of a cis-cyclic sulfate followed by amination and subsequent reductive amination. This strategy involving the nucleophilic opening of a cis-cyclic sulfate by sodium azide is to our knowledge the first example in C8-series. It revealead to be an efficient alternative to the nucleoplilic opening of an epoxide moiety which proved unsuccessful in this particular case, due to the hindered conformation of such epoxides as demonstrated by X-ray cristallographic analysis. Conclusion The biological activity of the synthesized glycomimetics has been evaluated towards 24 commercially available glycosidases. The weak observed activities can probably be related to the spatial disposition of the hydroxy and amino groups which depart too much from that realized in glycomimetics such as valiolamine, voglibose and valienamine. Nevertheless, the synthetic strategy described here is efficient and general, and could be extended to increase

  8. Direct observation of a high spin 12C + 8Be cluster state in 20Ne

    International Nuclear Information System (INIS)

    An 8+ state at Esub(e)sub(x) = 18.538 +- 0.010 MeV excitation in 20Ne was found to have a large reduced width for decay into 12C + 8Be. The state was populated using the 12C(12C,α)20Ne reaction at E(12C) = 64 and 80 MeV; its spin was determined by measuring triple α-α-γ angular correlations. Its relationship to other 8p-4h states in 20Ne is discussed. (orig.)

  9. Using public relations strategies to prompt populations at risk to seek health information: the Hanford Community Health Project.

    Science.gov (United States)

    Thomas, Gregory D; Smith, Stephen M; Turcotte, Joseph A

    2009-01-01

    The Hanford Community Health Project (HCHP) addressed health concerns among "downwinders" exposed to releases of radioactive iodine (I-131) from the Hanford Nuclear Reservation in the 1940s and 1950s. After developing educational materials and conducting initial outreach, HCHP had to decide whether to apply its limited resources to an advertising or public relations approach. The decision to apply public relations strategies was effective in driving awareness of the risk communication message at the community level, reinvigorating the affected community, and ultimately increasing the number of people who sought information about their risk of exposure and related health issues. HCHP used a series of communication tools to reach out to local and regional media, medical and health professionals, and community organizations. The campaign was successful in increasing the number of unique visitors to HCHP Web site and educating and activating the medical community around the releases of I-131 and patient care choices.

  10. Using public relations strategies to prompt populations at risk to seek health information: the Hanford Community Health Project.

    Science.gov (United States)

    Thomas, Gregory D; Smith, Stephen M; Turcotte, Joseph A

    2009-01-01

    The Hanford Community Health Project (HCHP) addressed health concerns among "downwinders" exposed to releases of radioactive iodine (I-131) from the Hanford Nuclear Reservation in the 1940s and 1950s. After developing educational materials and conducting initial outreach, HCHP had to decide whether to apply its limited resources to an advertising or public relations approach. The decision to apply public relations strategies was effective in driving awareness of the risk communication message at the community level, reinvigorating the affected community, and ultimately increasing the number of people who sought information about their risk of exposure and related health issues. HCHP used a series of communication tools to reach out to local and regional media, medical and health professionals, and community organizations. The campaign was successful in increasing the number of unique visitors to HCHP Web site and educating and activating the medical community around the releases of I-131 and patient care choices. PMID:18353906

  11. The Latino Mental Health Project: A Local Mental Health Needs Assessment

    OpenAIRE

    Cardemil, Esteban V.; Adams, Sara T.; Calista, Joanne L.; Connell, Joy; Encarnación, José; Esparza, Nancy K.; Frohock, Jeanne; Hicks, Ellen; Kim, Saeromi; Kokernak, Gerald; McGrenra, Michael; Mestre, Ray; Pérez, Maria; Pinedo, Tatiana M.; Quagan, Rosemary

    2007-01-01

    In this article, we present the results of a local needs assessment of the mental health experiences, service needs, and barriers to treatment-seeking of the Latino population in Worcester, Massachusetts. Overall, participants reported relatively high rates of experiences with symptoms of mental health problems, they indicated using a range of both formal and alternative mental health services, and they noted a variety of instrumental, attitudinal, and culturally-specific barriers to seeking ...

  12. The Utrecht Healthy School Project: Connecting adolescent health behavior, academic achievement and Health Promoting Schools

    OpenAIRE

    Busch, V.

    2014-01-01

    Unhealthy behaviors contribute to the development of diseases such as diabetes, cardiovascular disease and psychiatric disorders. Most often these behaviors develop in the teenage years. This thesis addresses the following topics: (1) How do health-related behaviors cluster and affect health in adolescents, (2) how do they affect their school performances and (3) are they improved by a Health Promoting School intervention that applies a Whole School Approach? Firstly, it was studied how healt...

  13. Implementing Brief Interventions in Health Care: Lessons Learned from the Swedish Risk Drinking Project

    Directory of Open Access Journals (Sweden)

    Per Nilsen

    2011-09-01

    Full Text Available The Risk Drinking Project was a national implementation endeavour in Sweden, carried out from 2004 to 2010, based on a government initiative to give alcohol issues a more prominent place in routine primary, child, maternity and occupational health care. The article describes and analyses the project. Critical factors that were important for the results are identified. The magnitude of the project contributed to its reach and impact in terms of providers’ awareness of the project goals and key messages. The timing of the project was appropriate. The increase in alcohol consumption in Sweden and diminished opportunities for primary prevention strategies since entry to the European Union in 1995 have led to increased expectations for health care providers to become more actively involved in alcohol prevention. This awareness provided favourable conditions for this project. A multifaceted approach was used in the project. Most educational courses were held in workshops and seminars to encourage learning-by-doing. Motivational interviewing was an integral aspect. The concept of risk drinking was promoted in all the activities. Subprojects were tailored to the specific conditions of each respective setting, building on the skills the providers already had to modify existing work practices. Nurses were afforded a key role in the project.

  14. Making mapping matter: a case study for short project international partnerships by global public health students

    OpenAIRE

    Wyber, Rosemary; Potter, James R.; Jennifer B. Weaver

    2014-01-01

    Background: A large number of global public health students seek international experience as part of their academic curriculum. These placements are often short, given the constraints of cost and time available within the academic calendar. In contrast to international electives for clinical students there are few published guidelines on practical, ethical or feasible projects. This paper describes a ten-day sanitation mapping project in Mumbai, India and explores the broader implications for...

  15. Experiences in Teaching Veterinary Public Health across Latin-America and Europe: the SAPUVETNET III Project

    OpenAIRE

    De Meneghi, Daniele; Cediel, Natalia; Vilhena, Manuela; Padre, Ludovina; Arroube, Sofia; Baltasar, Patricia; Villamil, Luis Carlos; Romero, Jaime; Sommerfelt, Irma; Keessen, Linny; Knapen, Frans van; Rosenfeld, Carla; Leguia, Guillermo; Falcon, Nestor; Torres, Miguel

    2011-01-01

    Experiences in Teaching Veterinary Public Health across Latin-America and Europe: the SAPUVETNET III Project SAPUVETNET III (n. DCI-LA/2008/75) is the third phase of a series of projects, co-financed under the EU ALFA programme, aimed to support a VPH network constituted by Faculties of Veterinary Medicine of 12 Latin-american and 6 European countries in addition to various collaborating institutions/organizations both at national and international level (http://www.sapuvetnet.org). The...

  16. EC multicentre study on short-term effects of air pollution on health. The aphea project

    Energy Technology Data Exchange (ETDEWEB)

    Katsouyanni, K. [Univ. of Athens (Greece). Medical School; Zmirou, D. [Grenoble Univ. (France). Faculte de Medecine; Spix, C. [GSF- Forschungszentrum Umwelt und Gesundheit (Germany)

    1995-12-31

    The APHEA project is an attempt to provide quantitative estimates of the short-term health effects of air pollution, using an extensive data base from ten different European countries which represent various social, environmental and air pollution situations. Within the framework of the project, the methodology of analyzing epidemiologic time series data, as well as that of performing meta-analysis, are further developed and standardized

  17. Reengineering and health physics within the project Hanford management contract

    International Nuclear Information System (INIS)

    The impending transition of the Hartford Site management and operations (M ampersand O) contract to a management and integrating (M ampersand I) contract format, together with weak radiological performance assessments by external organizations and reduced financial budgets prompted the 're-engineering' of the previous Hanford prime contractor Radiological Control (Rad Con) organization. This paper presents the methodology, identified areas of improvements, and results of the re-engineering process. The conversion from the M ampersand O to the M ampersand I contract concept resulted in multiple independent Rad Con organizations reporting to separate major contractors who are managed by an integrating contractor. This brought significant challenges when establishing minimum site standards for sitewide consistency, developing roles and responsibilities, and maintaining site Rad Con goals. Championed by the previous contractor's Rad Con Director, Denny Newland, a five month planning effort was executed to address the challenges of the M ampersand I and to address identified weaknesses. Fluor Daniel Hanford assumed the responsibility as integrator of the Project Hanford Management Contract on October 1, 1996. The Fluor Daniel Hanford Radiation Protection Director Jeff Foster presents the results of the re-engineering effort, including the significant cost savings, process improvements, field support improvements, and clarification of roles and responsibilities that have been achieved

  18. Relativistic calculations of $C_6$ and $C_8$ coefficients for strontium dimers

    CERN Document Server

    Porsev, S G; Clark, Charles W

    2014-01-01

    The electric dipole and quadrupole polarizabilities of the $5s5p~^3\\!P_1^o$ state and the $C_6$ and $C_8$ coefficients for the $^1\\!S_0 +\\, ^1\\!S_0$ and $^1\\!S_0 +\\, ^3\\!P_1^o$ dimers of strontium are calculated using a high-precision relativistic approach that combines configuration interaction and linearized coupled-cluster methods. Our recommended values of the long range dispersion coefficients for the $0_u$ and $1_u$ energy levels are $C_6(0_u)=3771(32)$ a.u. and $C_6(1_u)= 4001(33)$ a.u., respectively. They are in good agreement with recent results from experimental photoassociation data. We also calculate $C_8$ coefficients for Sr dimers, which are needed for precise determination of long-range interaction potential. We confirm the experimental value for the magic wavelength, where the Stark shift on the $^1\\!S_0$-$^3\\!P_1^o$ transition vanishes. The accuracy of calculations is analyzed and uncertainties are assigned to all quantities reported in this work.

  19. The Utrecht Healthy School Project: Connecting adolescent health behavior, academic achievement and Health Promoting Schools

    NARCIS (Netherlands)

    Busch, V.

    2014-01-01

    Unhealthy behaviors contribute to the development of diseases such as diabetes, cardiovascular disease and psychiatric disorders. Most often these behaviors develop in the teenage years. This thesis addresses the following topics: (1) How do health-related behaviors cluster and affect health in adol

  20. Health research 2000. Programme of the Federal German Government. Overview of projects '94

    International Nuclear Information System (INIS)

    The health research programme of the Federal German Government has existed since 1978. Its implementation has been reported on at regular intervals by project status reports. The last report appeared in 1991. This research promotion pursues the following aims: to enhance preventive health care, to elucidate the causes of diseases and find effective treatments, to develop further an efficient, financially acceptable health care system. The book has three main parts, in accordance with the three main research areas: Intersectorial reseach, health care and preventive health care, fighting of diseases. Within these three sectors, the main research activities carried out in 1994 are described. Each research activity is introduced with a brief text on its aims and state of progress; this is followed by a description of the projects carried out. The projects that were on-going in 1994 are outlined in concise form; finalized projects within each main research activity are shown in tabulated form with their most important characteristics. The annex contains some bibliographic items and addresses. (orig./VHE)

  1. The Monitoring Medicines Project: A Multinational Pharmacovigilance and Public Health Project

    OpenAIRE

    Pal, Shanthi N.; Olsson, Sten; Brown, Elliot G.

    2015-01-01

    The Monitoring Medicines project (MM), funded by the FP-7 EU framework, was carried out between 2009 and 2013 by a consortium of 11 partners. The objectives were to support and strengthen consumer reporting of adverse drug reactions (ADRs); expand the role and scope of national pharmacovigilance centres concerning medication errors; promote improved use of pharmacovigilance data; and develop methods to complement spontaneous reporting. The work was organised into four themes: patient reportin...

  2. Clinical characteristics of rod and cone photoreceptor dystrophies in patients with mutations in the C8orf37 gene

    NARCIS (Netherlands)

    Huet, R.A.C. van; Estrada-Cuzcano, A.; Banin, E.; Rotenstreich, Y.; Hipp, S.; Kohl, S.; Hoyng, C.B.; Hollander, A.I. den; Collin, R.W.J.; Klevering, B.J.

    2013-01-01

    PURPOSE: To provide the clinical features in patients with retinal disease caused by C8orf37 gene mutations. METHODS: Eight patients--four diagnosed with retinitis pigmentosa (RP) and four with cone-rod dystrophy (CRD), carrying causal C8orf37 mutations--were clinically evaluated, including extensiv

  3. Methodological approaches to evaluation of complex interventions in maternal and newborn health: IDEAS project

    OpenAIRE

    Hill, Z; Van Allen, E; Avan, BI; Berhanu, D; Gautham, M; Mangham-Jefferies, L; Makowiecka, K; Marchant, T; Rechel, B.; Schellenberg, JA; Spicer, N.; Kumar, N

    2012-01-01

    The IDEAS project aims to improve the health and survival of mothers and babies through generating evidence to inform policy and practice. IDEAS uses measurement, learning and evaluation to find out what works, why and how in maternal and newborn health. IDEAS is funded between 2010 and 2015 by a grant from the Bill & Melinda Gates Foundation to the London School of Hygiene & Tropical Medicine. This poster outlines the reseach objectives and how research questions will be addressed.

  4. SPATIAL ANALYSIS BASED HEALTH AND SAFETY RISK ASSESSMENT FOR LINEAR CONSTRUCTION PROJECTS

    OpenAIRE

    H. Atay; G. Toz

    2012-01-01

    This paper describes an on-going study that aims to develop a web-based spatial decision support system model for proactive health and safety management in linear construction projects. Currently, health and safety management is usually performed reactively instead of proactive management since hazard identification and risk assessment is mostly performed on paper based documents that are not effectively used at site. This leads to accidents and fatalities at construction sites. The proposed ...

  5. A Theoretical Investigation on the Reaction Mechanism of the C8H+·10 Side-Chain Decomposition Processes

    Institute of Scientific and Technical Information of China (English)

    CHENG Xue-Li; ZHAO Yan-Yun; LI Feng

    2008-01-01

    The dissociation of ethylbenzene cation C8H+·10 served as a prototype to investigate the decompasition mechanisms of alkylbenzene cations.The reactions of C8H+·10 decomposition reaction system have been studied extensively at the B3L YP/6-311++G** level with Gaussion 98 package.The chain reaction of C8H+·10 dissociation is initiated by C-H bond rupture.All reaction channels were fully investigated with the vibrational mode analysis to confirm the transition states and reveal the reaction mechanism.The energetically most favorable pathway is C8H+·10→TS4→·P2+H· and the channel ieading to C8H+·10 and C2H4 is also competitive.

  6. UMTRA project office federal employee occupational safety and health program plan

    International Nuclear Information System (INIS)

    This document establishes the Federal Employee Occupational Safety and Health (FEOSH) Program for the US Department of Energy (DOE) Uranium Mill Tailings Remedial Action (UMTRA) Project Office. This program will ensure compliance with applicable requirements of DOE Order 3790.1B and DOE Albuquerque Operations Office (AL) Order 3790.lA. FEOSH Program responsibilities delegated by the DOE-AL to the UMTRA Project Office by AL Order 3790.1A also are assigned. The UMTRA Project Office has developed the UMTRA Project Environmental, Safety, and Health (ES ampersand H) Plan (DOE, 1992), which establishes the basic programmatic ES ampersand H requirements for all participants on the UMTRA Project. The ES ampersand H plan is designed primarily to cover remedial action activities at UMTRA sites and defines the ES ampersand H responsibilities of both the UMTRA Project Office and its contractors. The UMTRA FEOSH Program described herein is a subset of the overall UMTRA ES ampersand H program and covers only federal employees working on the UMTRA Project

  7. Public library consumer health information pilot project: results of a National Library of Medicine evaluation.

    Science.gov (United States)

    Wood, F B; Lyon, B; Schell, M B; Kitendaugh, P; Cid, V H; Siegel, E R

    2000-10-01

    In October 1998, the National Library of Medicine (NLM) launched a pilot project to learn about the role of public libraries in providing health information to the public and to generate information that would assist NLM and the National Network of Libraries of Medicine (NN/LM) in learning how best to work with public libraries in the future. Three regional medical libraries (RMLs), eight resource libraries, and forty-one public libraries or library systems from nine states and the District of Columbia were selected for participation. The pilot project included an evaluation component that was carried out in parallel with project implementation. The evaluation ran through September 1999. The results of the evaluation indicated that participating public librarians were enthusiastic about the training and information materials provided as part of the project and that many public libraries used the materials and conducted their own outreach to local communities and groups. Most libraries applied the modest funds to purchase additional Internet-accessible computers and/or upgrade their health-reference materials. However, few of the participating public libraries had health information centers (although health information was perceived as a top-ten or top-five topic of interest to patrons). Also, the project generated only minimal usage of NLM's consumer health database, known as MEDLINEplus, from the premises of the monitored libraries (patron usage from home or office locations was not tracked). The evaluation results suggested a balanced follow-up by NLM and the NN/LM, with a few carefully selected national activities, complemented by a package of targeted activities that, as of January 2000, are being planned, developed, or implemented. The results also highlighted the importance of building an evaluation component into projects like this one from the outset, to assure that objectives were met and that evaluative information was available on a timely basis, as was

  8. Environmental health literacy within the Italian Asbestos Project: experience in Italy and Latin American contexts

    Directory of Open Access Journals (Sweden)

    Daniela Marsili

    2015-09-01

    Full Text Available The adoption of multidisciplinary approaches to foster scientific research in public health and strengthen its impact on society is nowadays unavoidable. Environmental health literacy (EHL may be defined as the ability to search for, understand, evaluate, and use environmental health information to promote the adoption of informed choices, the reduction of health risks, the improvement of quality of life and the protection of the environment. Both public health and environmental health literacy involve access to and dissemination of scientific information (including research findings, individual and collective decision-making and critical thinking. Specific experiences in environmental health literacy have been developed within the Italian National Asbestos Project (Progetto Amianto in Latin American countries where the use of asbestos is still permitted, and in Italy where a specific effort in EHL has been dedicated to the risks caused by the presence of fluoro-edenite fibers in the town of Biancavilla (Sicily. Taking into account the different geographical and socio-economic contexts, both public health and environmental health literacy were addressed to a wide range of stakeholders, within and outside the health domain.

  9. Avoiding Failure for Australia's Digital Health Record: The Findings from a Rural E-Health Participatory Research Project.

    Science.gov (United States)

    Almond, H; Cummings, E; Turner, P

    2016-01-01

    Low adoption and use of Australia's digital health record has driven the Australian Government to trial 'opt-out' registration from mid-June 2016. The assumption that automatic registration will increase use and thereby deliver benefit requires further investigation especially amongst those sections of the population in rural, regional, remote Australia living with complex chronic conditions. This paper reports on findings from a community based participatory e-health research project based on an initiative where people with complex chronic conditions and their carers attended a rural health promotion and lifestyle modification program. Through co-operative enquiry, health promotion officers and their clients were actively supported to adopt and use Australia's digital health record as an intervention. Simultaneously they were encouraged to reflect on its design and their perceptions of its overall impact on their individual ability to self-manage complex chronic conditions. The findings, ultimately contributing to a conceptual implementation and evaluation framework for Australia's digital health record that could directly avoid failure of the new 'opt-out' approach being adopted.

  10. Avoiding Failure for Australia's Digital Health Record: The Findings from a Rural E-Health Participatory Research Project.

    Science.gov (United States)

    Almond, H; Cummings, E; Turner, P

    2016-01-01

    Low adoption and use of Australia's digital health record has driven the Australian Government to trial 'opt-out' registration from mid-June 2016. The assumption that automatic registration will increase use and thereby deliver benefit requires further investigation especially amongst those sections of the population in rural, regional, remote Australia living with complex chronic conditions. This paper reports on findings from a community based participatory e-health research project based on an initiative where people with complex chronic conditions and their carers attended a rural health promotion and lifestyle modification program. Through co-operative enquiry, health promotion officers and their clients were actively supported to adopt and use Australia's digital health record as an intervention. Simultaneously they were encouraged to reflect on its design and their perceptions of its overall impact on their individual ability to self-manage complex chronic conditions. The findings, ultimately contributing to a conceptual implementation and evaluation framework for Australia's digital health record that could directly avoid failure of the new 'opt-out' approach being adopted. PMID:27440282

  11. Fall 2015 NASA Internship, and Space Radiation Health Project

    Science.gov (United States)

    Patience, Luke

    2015-01-01

    This fall, I was fortunate enough to have been able to participate in an internship at NASA's Lyndon B. Johnson Space Center. I was placed into the Human Health & Performance Directorate, where I was specifically tasked to work with Dr. Zarana Patel, researching the impacts of cosmic level radiation on human cells. Using different laboratory techniques, we were able to examine the cells to see if any damage had been done due to radiation exposure, and if so, how much damage was done. Cell culture samples were exposed at different doses, and fixed at different time points so that we could accumulate a large pool of quantifiable data. After examining quantifiable results relative to the impacts of space radiation on the human body at the cellular and chromosomal level, researchers can defer to different areas of the space program that have to do with astronaut safety, and research and development (extravehicular mobility unit construction, vehicle design and construction, etc.). This experience has been very eye-opening, and I was able to learn quite a bit. I learned some new laboratory techniques, and I did my best to try and learn new ways to balance such a hectic work and school schedule. I also learned some very intimate thing about working at NASA; I learned that far more people want to watch you succeed, rather than watch you fail, and I also learned that this is a place that is alive with innovators and explorers - people who have a sole purpose of exploring space for the betterment of humanity, and not for any other reason. It's truly inspiring. All of these experiences during my internship have impacted me in a really profound way, so much that my educational and career goals are completely different than when I started. I started out as a biotechnology major, and I discovered recently toward the end of the internship, that I don't want to work in a lab, nor was I as enthralled by biological life sciences as a believed myself to be. Taking that all into

  12. Synthesis of the C8’-epimeric thymine pyranosyl amino acid core of amipurimycin

    Science.gov (United States)

    Markad, Pramod R; Kumbhar, Navanath

    2016-01-01

    Summary The C8’-epimeric pyranosyl amino acid core 2 of amipurimycin was synthesized from D-glucose derived alcohol 3 in 13 steps and 14% overall yield. Thus, the Sharpless asymmetric epoxidation of allyl alcohol 7 followed by trimethyl borate mediated regio-selective oxirane ring opening with azide, afforded azido diol 10. The acid-catalyzed 1,2-acetonide ring opening in 10 concomitantly led to the formation of the pyranose ring skeleton to give 2,7-dioxabicyclo[3.2.1]octane 12. Functional group manipulation in 12 gave 21 that on stereoselective β-glycosylation afforded the pyranosyl thymine nucleoside 2 – a core of amipurimycin. PMID:27559421

  13. Stereoselective Luche reduction of deoxynivalenol and three of its acetylated derivatives at C8.

    Science.gov (United States)

    Fruhmann, Philipp; Hametner, Christian; Mikula, Hannes; Adam, Gerhard; Krska, Rudolf; Fröhlich, Johannes

    2014-01-01

    The trichothecene mycotoxin deoxynivalenol (DON) is a well known and common contaminant in food and feed. Acetylated derivatives and other biosynthetic precursors can occur together with the main toxin. A key biosynthetic step towards DON involves an oxidation of the 8-OH group of 7,8-dihydroxycalonectrin. Since analytical standards for the intermediates are not available and these intermediates are therefore rarely studied, we aimed for a synthetic method to invert this reaction, making a series of calonectrin-derived precursors accessible. We did this by developing an efficient protocol for stereoselective Luche reduction at C8. This method was used to access 3,7,8,15-tetrahydroxyscirpene, 3-deacetyl-7,8-dihydroxycalonectrin, 15-deacetyl-7,8-dihydroxycalonectrin and 7,8-dihydroxycalonectrin, which were characterized using several NMR techniques. Beside the development of a method which could basically be used for all type B trichothecenes, we opened a synthetic route towards different acetylated calonectrins. PMID:24434906

  14. Occupational Analysis: Hospital Radiologic Technologist. The UCLA Allied Health Professions Project.

    Science.gov (United States)

    Reeder, Glenn D.; And Others

    In an effort to meet the growing demand for skilled radiologic technologists and other supportive personnel educated through the associate degree level, a national survey was conducted as part of the UCLA Allied Health Professions Project to determine the tasks performed by personnel in the field and lay the groundwork for development of…

  15. Acute effects of ozone on mortality from the "Air pollution and health : A European approach" project

    NARCIS (Netherlands)

    Gryparis, A; Forsberg, B; Katsouyanni, K; Analitis, A; Touloumi, G; Schwartz, J; Samoli, E; Medina, S; Anderson, HR; Niciu, EM; Wichmann, HE; Kriz, B; Kosnik, M; Skorkovsky, J; Vonk, JM; Dortbudak, Z

    2004-01-01

    In the Air Pollution and Health: A European Approach (APHEA2) project, the effects of ambient ozone concentrations on mortality were investigated. Data were collected on daily ozone concentrations, the daily number of deaths, confounders, and potential effect modifiers from 23 cities/areas for at le

  16. Guatemala Project: The Traditional Laundering Place as a Non-Formal Health Education Setting

    Science.gov (United States)

    Colle, Royal D.

    1977-01-01

    Describes a nonformal adult education project designed to improve the health and nutrition of rural Guatemalan residents through the use of a traditional setting--the pila (an outdoor laundering place found throughout Guatemala), a modern medium (audio cassette and cassette player), and content which was a combination of modern and indigenous. (SH)

  17. Project BRIDGE--people with disabilities participate in their health care decisions.

    Science.gov (United States)

    Reynolds, D F

    1999-01-01

    Project BRIDGE is a complex of activities through which individuals affected by major mental illness, developmental disability, or the effects of aging become engaged in their health care decision making. This article explains the development of BRIDGE through the profound stories of Julia Warren, Theresa Draper, and Jim Overstreet. PMID:15675065

  18. 78 FR 36163 - Bitterroot National Forest, Darby Ranger District, Como Forest Health Project

    Science.gov (United States)

    2013-06-17

    ... general forest resilience to natural disturbances (native insects, diseases, and fire), and maintain the... Forest Service Bitterroot National Forest, Darby Ranger District, Como Forest Health Project AGENCY: Forest Service, USDA. ACTION: Notice of intent to prepare an environmental impact statement. SUMMARY:...

  19. The Role of Social Relationships in Predicting Loneliness: The National Social Life, Health, and Aging Project

    Science.gov (United States)

    Shiovitz-Ezra, Sharon; Leitsch, Sara A.

    2010-01-01

    The authors explore associations between objective and subjective social network characteristics and loneliness in later life, using data from the National Social Life, Health, and Aging Project, a nationally representative sample of individuals ages 57 to 85 in the United States. Hierarchical linear regression was used to examine the associations…

  20. NIH funds Virginia Tech project to help senior citizens access health care

    OpenAIRE

    Benton, Netta

    2004-01-01

    The National Institutes of Health (NIH) has awarded funding to computer science researchers in the Virginia Tech College of Engineering for a project aimed at making it easier for senior citizens to access Virginia Department for the Aging (VDA) services on the World Wide Web.

  1. Dissemination activity and impact of maternal and newborn health projects in Ethiopia, India and Nigeria

    OpenAIRE

    Voller, S; Becker, AJ

    2014-01-01

    This study aimed to document the key messages, dissemination activities and impacts of selected projects within the Bill & Melinda Gates Foundation Maternal, Neonatal and Child Health strategy portfolio, and consider how these might contribute toward the learning agenda for the strategy.

  2. Growth directions of C8-BTBT thin films during drop-casting

    Science.gov (United States)

    Iizuka, Naoki; Zanka, Tomohiko; Onishi, Yosuke; Fujieda, Ichiro

    2016-02-01

    Because charge transport in a single crystal is anisotropic, control of its orientation is important for enhancing electrical characteristics and reducing variations among devices. For growing an organic thin film, a solution process such as inkjet printing offers advantages in throughput. We have proposed to apply an external temperature gradient during drop-casting and to control the direction of solvent evaporation. In experiment, a temperature gradient was generated in a bare Si substrate by placing it on a Si plate bridging two heat stages. When a solution containing 2,7-dioctyl [1]benzothieno[3,2-b]benzothiophene (C8-BTBT) was dropped on the substrate, evaporation started at the hotter side of the droplet and proceeded toward the colder side. The front line of the liquid was not pinned and the solution extended toward the colder region. As a result, a thin film was formed in a 7mm-long region. The peripheral region of the film was significantly thicker due to the coffee ring effect. The surface of the rest of the film was mostly smooth and terrace structures with 2.6nm steps were observed. The step roughly corresponds to the length of the C8-BTBT molecule. The film thickness varied from 20nm to 50nm over the distance of 3mm. Another film was grown on a glass substrate under a similar condition. Observation of the film with a polarizing microscope revealed that fan-shaped domains were formed in the film and that their optical axes were mostly along the directions of the solvent evaporation.

  3. Chernobyl Studies Project - working group 7.0 environmental transport and health effects

    International Nuclear Information System (INIS)

    The DOE-funded Chernobyl Studies Project was begun as part of a cooperative agreement between the US and the former USSR, (quote) To develop jointly methods to project rapidly the health effects of any future reactor accident (quote). Most of the initial tasks for this project are completed or near completion. The focus has now turned primarily to the issue of health effects from the Chernobyl accident. Currently, we are extensively engaged in case-control and cohort studies of thyroid diseases among Belarussian children and in the Ukraine. A major part of the effort is providing methods and applications of dose reconstruction and providing support and equipment for the medical teams. This document contains reports on progress in the following task areas: Management; External Dose; Hydrological Transport; Chromosome Painting Dosimetry; Stochastic Effects; Thyroid Studies; and Leukemia Studies

  4. Tuberculosis infection control in health facilities in Lithuania: lessons learnt from a capacity support project.

    Science.gov (United States)

    Turusbekova, N; Ljungqvist, I; Davidavičiene, E; Mikaityte, J; van der Werf, M J

    2016-03-21

    Tuberculosis (TB) infection control (IC) is key in controlling TB transmission in health facilities in Lithuania. This article presents a project that aimed at supporting health care facilities in Lithuania in implementing TB-IC. The project consisted of 1) facility TB-IC assessments, 2) development of facility TB-IC plans, 3) TB-IC training and 4) site visits. We assessed the impact of these activities through a self-assessment questionnaire. The project resulted in limited improvements. Most progress was seen in administrative and managerial activities. Possible reasons for the limited improvements are challenges with funding and the lack of supportive legislation and a national TB-IC plan. PMID:27051607

  5. mHealth Series: mHealth project in Zhao County, rural China – Description of objectives, field site and methods

    Directory of Open Access Journals (Sweden)

    Michelle Helena van Velthoven

    2013-12-01

    Full Text Available We set up a collaboration between researchers in China and the UK that aimed to explore the use of mHealth in China. This is the first paper in a series of papers on a large mHealth project part of this collaboration. This paper included the aims and objectives of the mHealth project, our field site, and the detailed methods of two studies.

  6. The Monterey County Health Initiative. A post-mortem analysis of a California Medicaid demonstration project.

    Science.gov (United States)

    Aved, B M

    1987-01-01

    Twenty months after the California State Department of Health Services turned its Medicaid program in Monterey County over to a local health care authority, the Monterey County Health Initiative (MCHI), the state terminated the pilot project in favor of a return to fee-for-service reimbursement. The MCHI, plagued from its inception with shaky provider support and a flawed program design, failed to demonstrate its anticipated cost savings. The key features of this failure were overly generous fees for primary case managers, inadequate utilization control measures, a general hesitancy to assume the necessary gatekeeper function, and a management information system that was not fully operational until well into the implementation of the program. Policy implications and recommendations for future state-sponsored Medicaid demonstration projects are discussed. PMID:3543525

  7. [Methods for health impact assessment of policies for municipal solid waste management: the SESPIR Project].

    Science.gov (United States)

    Parmagnani, Federica; Ranzi, Andrea; Ancona, Carla; Angelini, Paola; Chiusolo, Monica; Cadum, Ennio; Lauriola, Paolo; Forastiere, Francesco

    2014-01-01

    The Project Epidemiological Surveillance of Health Status of Resident Population Around the Waste Treatment Plants (SESPIR) included five Italian regions (Emilia-Romagna, Piedmont, Lazio, Campania, and Sicily) and the National Institute of Health in the period 2010-2013. SESPIR was funded by the Ministry of Health as part of the National centre for diseases prevention and control (CCM) programme of 2010 with the general objective to provide methods and operational tools for the implementation of surveillance systems for waste and health, aimed at assessing the impact of the municipal solid waste (MSW) treatment cycle on the health of the population. The specific objective was to assess health impacts resulting from the presence of disposal facilities related to different regional scenarios of waste management. Suitable tools for analysis of integrated assessment of environmental and health impact were developed and applied, using current demographic, environmental and health data. In this article, the methodology used for the quantitative estimation of the impact on the health of populations living nearby incinerators, landfills and mechanical biological treatment plants is showed, as well as the analysis of three different temporal scenarios: the first related to the existing plants in the period 2008-2009 (baseline), the second based on regional plans, the latter referring to MSW virtuous policy management based on reduction of produced waste and an intense recovery policy. PMID:25387745

  8. Effect of C8mimPF6 on miniemulsion polymerization for application in new latex coating products.

    Science.gov (United States)

    Hu, Binjie; Kong, Yiyang; Zheng, Rongmeihui; Dong, Jie; Choy, Kwang-Leong; Zhao, Huanhuan

    2016-08-15

    C8mimPF6, as a type of room temperature ionic liquid (RTIL) with non-volatility and a low melting point, may replace conventional coalescing agents in latex coatings, thus preventing volatile organic compound (VOC) emissions caused by coalescing agents. In this study, systematic investigations on the effect of various factors including initiator type, initiator concentration, temperature and C8mimPF6 concentration on the conversion of latex and droplet/particle size of a miniemulsion during polymerization have been conducted. The presence of C8mimPF6 has shown to have a marked effect on the reaction rate. Such an effect strongly depends on the type of initiator being used. For polymerization initiated by 2,2-azobis (isobutyronitrile) (AIBN), C8mimPF6 had a promoting effect on the reaction rate at low concentrations, but this effect might be reversed upon certain C8mimPF6 concentrations, e.g. 10 wt%. While initiated by H2O2/Vc, this promoting effect faded even at low C8mimPF6 concentrations. The different limiting factors, which determine the reaction rate with different types of initiator, may contribute to the results. For reactions initiated by hydrophobic AIBN, the reaction was dominated by kinetics. The presence of C8mimPF6 may cause an enhanced chain propagation rate and reduced chain termination rate, which may further contribute to the increase in reaction rate at lower concentrations of C8mimPF6. With hydrophilic H2O2/Vc, the resistance for the transfer of radicals into a droplet/particle might be increased significantly with increasing C8mimPF6 concentration due to a tighter interfacial structure at lower concentrations of C8mimPF6. Thus, such transfer of radicals may become a limiting step whilst the presence of C8mimPF6 increases the transfer resistance on radicals resulting in a decrease in reaction rate. The reaction temperature, which is related to the decomposition temperature of the initiator being used, was another factor affecting the conversion

  9. Air Pollution and Climate Change Health Impact Assessment. The ACHIA Project

    International Nuclear Information System (INIS)

    Climate change may affect human health via interactions with air pollutants such as ozone and PM2.5. These air pollutants are linked to climate because they can be both affected by and have effects on climate. In coming decades, substantial, cost-effective improvements in public health may be achieved with well-planned strategies to mitigate climate impacts while also reducing health effects of ozone and PM2.5. Climate mitigation actions affect greenhouse pollutant emissions, including methane and black carbon, but also may affect other key air pollution precursors such as NOx, CO, and SOx. To better understand the potential of such strategies, studies are needed that assess possible future health impacts under alternative assumptions about future emissions and climate across multiple spatial scales. The overall objective of this project is to apply state of the art climate, air quality, and health modelling tools to assess future health impacts of ozone and PM2.5 under different IPCCs scenario of climate change, focusing specifically on pollution-related health co-benefits which could be achieved under alternative climate mitigation pathways in the period 2030-2050. This question will be explored at three spatial scales: global, regional (Europe), and urban (Paris). ACHIA is comprised of an integrated set of four work packages: WP1. Global Climate and Air Pollution Impacts of Alternative Emissions Pathways; WP2. Climate and Air Quality at Regional and Urban Scales: Results for Europe and Paris; WP3. Health Impact Assessment; WP4. Dissemination, Evaluation, Management. ACHIA is designed to create an interdisciplinary approach to the impacts of climate change on health through air quality changes, and to start longer-term collaborations between communities. We expect the project to advance state of art across all WPs, with important implications for research groups around the world. A particular innovation of the project is the multi-scale aspect, i.e., the analysis

  10. The Effect of an Interdisciplinary Community Health Project on Student Attitudes toward Community Health, People Who Are Indigent and Homeless, and Team Leadership Skill Development.

    Science.gov (United States)

    Rose, Molly A.; Lyons, Kevin J.; Miller, Kathleen Swenson; Cornman-Levy, Diane

    2003-01-01

    A study of 22 health occupations students examined whether participation in an interdisciplinary community health empowerment project with urban homeless and formerly homeless people changed their attitudes about community health practice, attitudes toward people who are indigent and homeless, and perceived leadership skills. Posttests revealed a…

  11. Students Development of Food and Health-Related Action Competence - Upscaling LOMA Project

    DEFF Research Database (Denmark)

    Ruge, Dorte; Nielsen, Morten Kromann; Jensen, Kirsten;

    2015-01-01

    producers and food communities. All project activities in LOMA I and LOMA II has been facilitated by 'community of practices' (Wenger 2000), that aim at promoting health, learning and sustainable development. The authors regard these activities to be of interest for a broader internatioal audience...... generation of LOMA-local food project and the protocol for evaluation. The first generation LOMA project consisted of a combined development- and research project (2011-2014). Due to financial support from the Nordea-foundation, upscaling to five more schools during 2015-2017has now facilitated the LOMA II......, pedagogs and students (8-15 years) and teacher-students. It is expected, that LOMA II will contribute to students' development of components of food and healt-related action competence as learning outcomes. Among these are knowledge, insight, skills, motivation, ownership and critical thinking. Moreover...

  12. The Utrecht Health Project: Optimization of routine healthcare data for research

    International Nuclear Information System (INIS)

    Background. Research on the impact of changes in healthcare policy, developments in community and public health and determinants of health and disease during lifetime may effectively make use of routine healthcare data. These data, however, need to meet minimal criteria for quality and completeness. Research opportunities are further improved when routine data are supplemented with a standardized 'baseline' assessment of the full population. This formed the basis for a new study initiated in a newly developed large residential area in Leidsche Rijn, part of the city of Utrecht, the Netherlands.Methods. All new inhabitants are invited by their general practitioner to participate in the Utrecht Health Project (UHP). Informed consent is obtained and an individual health profile (IHP) is made by dedicated research nurses. The IHP is the starting point for the UHP research database as well as for the primary care electronic medical records. Follow-up data are collected through continuous linkage with the computerized medical files recorded by the general practitioners. UHP staff in each practice takes care of quality management of registration as well as data handling.Results. Currently, over 60 of invited new residents in the area have given informed consent with participation steadily increasing. Discussion. The Utrecht Health Project combines key elements of traditional epidemiologic cohort studies with the current power of routine electronic medical record keeping in primary care. The research approach optimizes routine health care data for use in scientific research

  13. Design, Implementation, and Lessons Learned from a Digital Storytelling Project in an Undergraduate Health Promotion Theory Course

    Science.gov (United States)

    Rimando, Marylen; Smalley, K. Bryant; Warren, Jacob C.

    2015-01-01

    This article describes the design, implementation and lessons learned from a digital storytelling project in a health promotion theory course. From 2011-2012, 195 health promotion majors completed a digital storytelling project at a Midwestern university. The instructor observed students' understanding of theories and models. This article adds to…

  14. Championing mental health at work: emerging practice from innovative projects in the UK.

    Science.gov (United States)

    Robinson, Mark; Tilford, Sylvia; Branney, Peter; Kinsella, Karina

    2014-09-01

    This paper examines the value of participatory approaches within interventions aimed at promoting mental health and wellbeing in the workplace. Specifically the paper explores data from the thematic evaluation of the Mental Health and Employment project strand within the Altogether Better programme being implemented in England in the Yorkshire and Humber region, which was funded through the BIG Lottery and aimed to empower people across the region to lead better lives. The evaluation combined a systematic evidence review with semi-structured interviews across mental health and employment projects. Drawing on both evaluation elements, the paper examines the potential of workplace-based 'business champions' to facilitate organizational culture change within enterprises within a deprived regional socio-economic environment. First, the paper identifies key policy drivers for interventions around mental health and employment, summarizes evidence review findings and describes the range of activities within three projects. The role of the 'business champion' emerged as crucial to these interventions and therefore, secondly, the paper examines how champions' potential to make a difference depends on the work settings and their existing roles, skills and motivation. In particular, champions can proactively coordinate project strands, embed the project, encourage participation, raise awareness, encourage changes to work procedures and strengthen networks and partnerships. The paper explores how these processes can facilitate changes in organizational culture. Challenges of implementation are identified, including achieving leverage with senior management, handover of ownership to fellow employees, assessing impact and sustainability. Finally, implications for policy and practice are discussed, and conclusions drawn concerning the roles of champions within different workplace environments. PMID:23300189

  15. SPATIAL ANALYSIS BASED HEALTH AND SAFETY RISK ASSESSMENT FOR LINEAR CONSTRUCTION PROJECTS

    Directory of Open Access Journals (Sweden)

    H. Atay

    2012-07-01

    Full Text Available This paper describes an on-going study that aims to develop a web-based spatial decision support system model for proactive health and safety management in linear construction projects. Currently, health and safety management is usually performed reactively instead of proactive management since hazard identification and risk assessment is mostly performed on paper based documents that are not effectively used at site. This leads to accidents and fatalities at construction sites. The proposed system automatically identifies the spatial risks according to the topographic and layout map of the site, project specification and health and safety regulations by means of spatial analysis. It enables the workers and management personnel to access the possible hazards and thematic risk map of any portion of the construction site for linear projects. Finally, the described approach provides the proposed mitigation measures for the identified hazards. The developed system is expected to raise awareness in H&S among workers and engineers, and increase participation of workers to health and safety management.

  16. Spatial Analysis Based Health and Safety Risk Assessment for Linear Construction Projects

    Science.gov (United States)

    Atay, H.; Toz, G.

    2012-07-01

    This paper describes an on-going study that aims to develop a web-based spatial decision support system model for proactive health and safety management in linear construction projects. Currently, health and safety management is usually performed reactively instead of proactive management since hazard identification and risk assessment is mostly performed on paper based documents that are not effectively used at site. This leads to accidents and fatalities at construction sites. The proposed system automatically identifies the spatial risks according to the topographic and layout map of the site, project specification and health and safety regulations by means of spatial analysis. It enables the workers and management personnel to access the possible hazards and thematic risk map of any portion of the construction site for linear projects. Finally, the described approach provides the proposed mitigation measures for the identified hazards. The developed system is expected to raise awareness in H&S among workers and engineers, and increase participation of workers to health and safety management.

  17. Optical and Morphological Studies of Thermally Evaporated PTCDI-C8 Thin Films for Organic Solar Cell Applications

    Directory of Open Access Journals (Sweden)

    Ronak Rahimi

    2013-01-01

    Full Text Available PTCDI-C8 due to its relatively high photosensitivity and high electron mobility has attracted much attention in organic semiconductor devices. In this work, thin films of PTCDI-C8 with different thicknesses were deposited on silicon substrates with native silicon dioxide using a vacuum thermal evaporator. Several material characterization techniques have been utilized to evaluate the structure, morphology, and optical properties of these films. Their optical constants (refractive index and extinction coefficient have been extracted from the spectroscopic ellipsometry (SE. X-ray reflectivity (XRR and atomic force microscopy (AFM were employed to determine the morphology and structure as well as the thickness and roughness of the PTCDI-C8 thin films. These films revealed a high degree of structural ordering within the layers. All the experimental measurements were performed under ambient conditions. PTCDI-C8 films have shown to endure ambient condition which allows pots-deposition characterization.

  18. Environmental Scanning as a Public Health Tool: Kentucky's Human Papillomavirus Vaccination Project.

    Science.gov (United States)

    Wilburn, Amanda; Vanderpool, Robin C; Knight, Jennifer R

    2016-01-01

    Borrowing from business, quality improvement programs, and strategic planning principles, environmental scanning is gaining popularity in public health practice and research and is advocated as an assessment and data collection tool by federal funding agencies and other health-related organizations. Applicable to a range of current and emerging health topics, environmental scans - through various methods - assess multiple facets of an issue by engaging stakeholders who can ask or answer research questions, exploring related policy, critiquing published and gray literature, collecting and analyzing qualitative and quantitative data in both primary and secondary forms, disseminating findings to internal and external stakeholders, and informing subsequent planning and decision making. To illustrate the environmental scanning process in a public health setting and showcase its value to practitioners in the field, we describe a federally funded environmental scan for a human papillomavirus vaccination project in Kentucky. PMID:27536901

  19. Environmental Scanning as a Public Health Tool: Kentucky’s Human Papillomavirus Vaccination Project

    Science.gov (United States)

    Wilburn, Amanda; Knight, Jennifer R.

    2016-01-01

    Borrowing from business, quality improvement programs, and strategic planning principles, environmental scanning is gaining popularity in public health practice and research and is advocated as an assessment and data collection tool by federal funding agencies and other health-related organizations. Applicable to a range of current and emerging health topics, environmental scans — through various methods — assess multiple facets of an issue by engaging stakeholders who can ask or answer research questions, exploring related policy, critiquing published and gray literature, collecting and analyzing qualitative and quantitative data in both primary and secondary forms, disseminating findings to internal and external stakeholders, and informing subsequent planning and decision making. To illustrate the environmental scanning process in a public health setting and showcase its value to practitioners in the field, we describe a federally funded environmental scan for a human papillomavirus vaccination project in Kentucky. PMID:27536901

  20. CYP2C8 Is a Novel Target of Peroxisome Proliferator-Activated Receptor α in Human Liver.

    Science.gov (United States)

    Makia, Ngome L; Goldstein, Joyce A

    2016-01-01

    Human cytochrome P450 (CYP) 2C enzymes metabolize ∼30% of clinically prescribed drugs and various environmental chemicals. CYP2C8, an important member of this subfamily, metabolizes the anticancer drug paclitaxel, certain antidiabetic drugs, and endogenous substrates, including arachidonic acid, to physiologically active epoxyeicosatrienoic acids. Previous studies from our laboratory showed that microRNA 107 (miR107) and microRNA 103 downregulate CYP2C8 post-transcriptionally. miR107 is located in intron 5 of the pantothenate kinase 1 (PANK1) gene. p53 has been reported to coregulate the induction of PANK1 and miR107. Here, we examine the possible downregulation of CYP2C8 by drugs capable of inducing miR107. Hypolipidemic drugs, such as bezafibrate, known activators of the peroxisome proliferator-activated receptor α (PPARα), induce both the PANK1 gene and miR107 (∼2.5-fold) in primary human hepatocytes. Surprisingly, CYP2C8 mRNA and protein levels were induced by bezafibrate. CYP2C8 promoter activity was increased by ectopic expression of PPARα in HepG2 cells, with a further increase after bezafibrate (∼18-fold), 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio acetic acid (∼10-fold) treatment, or the antidiabetic drug rosiglitazone, all known PPAR activators. Promoter sequence analyses, deletion studies, mutagenesis studies, and electrophoretic mobility shift assays identified a PPARα response element located at position -2109 base pair relative to the translation start site of CYP2C8. Chromatin immunopreciptation assay analysis confirmed recruitment of PPARα to this PPARα response element after bezafibrate treatment of human hepatocytes. Thus, we show for the first time that CYP2C8 is transcriptionally regulated by PPARα, suggesting the potential for drug-drug interactions due to upregulation of CYP2C8 by PPAR activators. PMID:26467040

  1. Drug-drug Interaction between Losartan and Paclitaxel in Human Liver Microsomes with Different CYP2C8 Genotypes.

    Science.gov (United States)

    Mukai, Yuji; Senda, Asuna; Toda, Takaki; Hayakawa, Toru; Eliasson, Erik; Rane, Anders; Inotsume, Nobuo

    2015-06-01

    The cytochrome P450 (CYP) 2C8*3 allele is associated with reduced metabolic activity of paclitaxel. This study was aimed to investigate the inhibitory effect of losartan on paclitaxel metabolism in human liver microsomes (HLMs) and to determine the impact of the CYP2C8*3 polymorphism. HLMs that contained the CYP2C8*1 homozygote (HL60) or CYP2C8*3 heterozygote (HL54) genotype were used for the inhibition study. Losartan, at a concentration of 50 μmol/L, significantly inhibited paclitaxel metabolism by 29% and 57% in the HL60 (p losartan and the CYP3A4-selective inhibitors, erythromycin and ketoconazole, caused a greater inhibition of the paclitaxel metabolism than quercetin, a CYP2C8-selective inhibitor. This demonstrated that the paclitaxel metabolism was mainly catalysed by CYP3A4 in HL60. There were no significant differences found for the inhibitory effects caused by the four inhibitors of the paclitaxel metabolism in HL54, indicating that both CYP2C8 and CYP3A4 play important roles in paclitaxel metabolism in HL54. These findings suggest that 50 μmol/L of losartan inhibits both CYP2C8 and CYP3A4 in HLMs. In summary, losartan inhibited paclitaxel metabolism, with concentrations over 50 μmol/L in HLMs. The CYP2C8*3 allele carriers are likely susceptible to the interactions of losartan and CYP3A4 inhibitors to paclitaxel metabolism.

  2. C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling

    OpenAIRE

    Zhu, Pingping; Wang, Yanying; Du, Ying; He, Lei; Huang, Guanling; Zhang, Geng; Yan, Xinlong; Fan, Zusen

    2015-01-01

    Liver cancer stem cells (CSCs) harbour self-renewal and differentiation properties, accounting for chemotherapy resistance and recurrence. However, the molecular mechanisms to sustain liver CSCs remain largely unknown. In this study, based on analysis of several hepatocellular carcinoma (HCC) transcriptome datasets and our experimental data, we find that C8orf4 is weakly expressed in HCC tumours and liver CSCs. C8orf4 attenuates the self-renewal capacity of liver CSCs and tumour propagation. ...

  3. CYP2C8 and CYP2C9 mRNA expression profile in the human fetus

    Directory of Open Access Journals (Sweden)

    Maria eJohansson

    2014-03-01

    Full Text Available CYP2C8 and CYP2C9 are involved in the inactivation of several NSAIDs, including ibuprofen. CYP2C9 is the major form in human liver whereas CYP2C8 has been proposed to be the main CYP2C enzyme in fetal liver. The protein expression of CYP2C9 in the first trimester is low, only about 1% of the adult values, whereas the mRNA levels of CYP2C8/9 have not been determined at the fetal stage. In this study the mRNA expression levels of CYP2C8 and CYP2C9 were determined in 20 adult and 60 fetal liver tissue specimens. The expression profiles in fetal kidneys (n = 43, adrenals (n = 46, and lungs (n = 37 were also determined. Moreover the activity against ibuprofen hydroxylation was a determined in fetus and adult liver microsomes. Adult liver samples expressed 140 and 400 times higher levels of CYP2C8 and CYP2C9 mRNA, respectively as compared to fetal liver samples. Consistent with this, the hydroxylation of ibuprofen was 40 times higher in the adult liver microsomes. Hepatic CYP2C8 mRNA was three times more abundant than CYP2C9 mRNA in the fetus. Moreover, CYP2C8 were consistently expressed in all fetal tissues investigated, whereas CYP2C9 gene expression was confined to the liver in fetuses. Our results indicate that CYP2C8 plays a more important physiological role than CYP2C9 in the first trimester.

  4. Introduction of the World Health Organization project of the International Classification of Traditional Medicine.

    Science.gov (United States)

    Gao, Peng-fei; Watanabe, Kenji

    2011-11-01

    The World Health Organization plans to incorporate "traditional medicine" into the next revision of its International Classification of Diseases-Version 11 (ICD-11). If traditional medicine is included in ICD-11, it is definitely an epoch-making issue. The expected result is the International Classification of Traditional Medicine, China, Japan and Korea Version (ICTM-CJK). The intention of the ICTM project is not only beneficial for traditional medical components, but also might be beneficial for Western biomedicine. For this shared purpose, China, Japan and Korea must understand the meaning of this project and collaborate to develop it.

  5. Can a quality improvement project impact maternal and child health outcomes at scale in northern Ghana?

    OpenAIRE

    Singh, Kavita; Brodish, Paul; Speizer, Ilene; Barker, Pierre; Amenga-Etego, Issac; Dasoberi, Ireneous; Kanyoke, Ernest; Boadu, Eric A.; Yabang, Elma; Sodzi-Tettey, Sodzi

    2016-01-01

    Background Quality improvement (QI) interventions are becoming more common in low- and middle-income countries, yet few studies have presented impact evaluations of these approaches. In this paper, we present an impact evaluation of a scale-up phase of ‘Project Fives Alive!’, a QI intervention in Ghana that aims to improve maternal and child health outcomes. ‘Project Fives Alive!’ employed a QI methodology to recognize barriers to care-seeking and care provision at the facility level and then...

  6. Chernobyl Studies Project. Working Group 7.0, environmental transport and health effects

    International Nuclear Information System (INIS)

    The focus of the Chernobyl Studies Project has now turned to the issue of health effects from the Chernobyl accident. Currently, we are involved in and making progress on the case-control and co-hort studies of thyroid diseases among Belarussian children. Dosimetric aspects are a fundamental part of these studies. We are working to implement similar studies in Ukraine. A major part of the effort of these projects is supporting these studies, both by providing methods and applications of dose reconstruction and by providing support and equipment for the medical teams

  7. The effects of human CYP2C8 genotype and fluvoxamine on the pharmacokinetics of rosiglitazone in healthy subjects

    DEFF Research Database (Denmark)

    Pedersen, Rasmus S; Damkier, Per; Brosen, Kim

    2006-01-01

    AIMS: To determine the effect of CYP2C8 genotype and of fluvoxamine on the pharmacokinetics of rosiglitazone. METHODS: Twenty-three healthy subjects with the following genotypes were included in a two-phase, open-label, cross-over trial: CYP2C8*3/ *3 (n = 3), CYP2C8*1/ *3 (n = 10) and CYP2C8*1/ *1...... and relative amounts of N-desmethylrosiglitazone were measured in both phases for 24 h after drug administration. RESULTS: The pharmacokinetics of rosiglitazone and N-desmethylrosiglitazone were not significantly different between the CYP2C8 genotypic groups. Fluvoxamine caused a statistically significant (P...... of fluvoxamine had no influence on the pharmacokinetics of N-desmethylrosiglitazone. CONCLUSION: The importance of the CYP2C8*3 mutation in the in vivo metabolism of rosiglitazone could not be confirmed. Fluvoxamine increased the AUC(0-infinity) and t(1/2) of rosiglitazone moderately and hence may be a weak...

  8. Planning for better animal health and welfare, Report from the 1st ANIPLAN project workshop, Hellevad, October 2007

    OpenAIRE

    Vaarst, Mette; Leeb, Christine; Nicholas, Phillipa; Roderick, Stephen; Smolders, Gidi; Walkenhorst, Michael; Brinkmann, Jan; March, Solveig; Stöger, Elisabeth; Winkler, Christoph; Gratzer, Elisabeth; Lund, Vonne; Henriksen, Britt I. F.; Hansen, Inger; Neale, Madeleine

    2008-01-01

    ’Minimising medicine use in organic dairy herds through animal health and welfare planning’, ANIPLAN, is a CORE-Organic project which was initiated in June 2007. The main aim of the project is to investigate active and well planned animal health and welfare promotion and disease prevention as a means of minimising medicine use in organic dairy herds. This aim will be met through the development of animal health and welfare planning principles for organic dairy farms under diverse conditions b...

  9. Electronic medical records: recommendations for routine. Report of the eHID (Electronic Health Indicator Data Project): the eHID project recommendations.

    NARCIS (Netherlands)

    Pringle, M.; Schellevis, F.G.; Elliott, C.; Fleming, D.M.

    2007-01-01

    Aims: eHID (electronic Health Indicator Data) is an EC sponsored project concerned with best practice in recording diagnostic data in routine ( as opposed to research specific) general practice electronic patient records. Design and methods: The project included investigation on site of recording r

  10. NASA Human Health and Performance Center: Open innovation successes and collaborative projects

    Science.gov (United States)

    Richard, Elizabeth E.; Davis, Jeffrey R.

    2014-11-01

    In May 2007, what was then the Space Life Sciences Directorate published the 2007 Space Life Sciences Strategy for Human Space Exploration, setting the course for development and implementation of new business models and significant advances in external collaboration over the next five years. The strategy was updated on the basis of these accomplishments and reissued as the NASA Human Health and Performance Strategy in 2012, and continues to drive new approaches to innovation for the directorate. This short paper describes the successful execution of the strategy, driving organizational change through open innovation efforts and collaborative projects, including efforts of the NASA Human Health and Performance Center (NHHPC).

  11. Is the Alma Ata vision of comprehensive primary health care viable? Findings from an international project

    Directory of Open Access Journals (Sweden)

    Ronald Labonté

    2014-08-01

    Full Text Available Background: The 4-year (2007–2011 Revitalizing Health for All international research program (http://www.globalhealthequity.ca/projects/proj_revitalizing/index.shtml supported 20 research teams located in 15 low- and middle-income countries to explore the strengths and weaknesses of comprehensive primary health care (CPHC initiatives at their local or national levels. Teams were organized in a triad comprised of a senior researcher, a new researcher, and a ‘research user’ from government, health services, or other organizations with the authority or capacity to apply the research findings. Multiple regional and global team capacity-enhancement meetings were organized to refine methods and to discuss and assess cross-case findings. Objective: Most research projects used mixed methods, incorporating analyses of qualitative data (interviews and focus groups, secondary data, and key policy and program documents. Some incorporated historical case study analyses, and a few undertook new surveys. The synthesis of findings in this report was derived through qualitative analysis of final project reports undertaken by three different reviewers. Results: Evidence of comprehensiveness (defined in this research program as efforts to improve equity in access, community empowerment and participation, social and environmental health determinants, and intersectoral action was found in many of the cases. Conclusions: Despite the important contextual differences amongst the different country studies, the similarity of many of their findings, often generated using mixed methods, attests to certain transferable health systems characteristics to create and sustain CPHC practices. These include: 1. Well-trained and supported community health workers (CHWs able to work effectively with marginalized communities 2. Effective mechanisms for community participation, both informal (through participation in projects and programs, and meaningful consultation and formal

  12. Project ‘play and tell’: occupational therapy in primary health care

    Directory of Open Access Journals (Sweden)

    Débora Barbosa e Alcântara

    2012-12-01

    Full Text Available This paper reports the experience of a “storytelling and playing” group that took place in a FamilyHealth Unit in Sao Carlos, State of Sao Paulo. The group was formed as from the evaluation of the occupationaltherapist in the context of Primary Health Care, which broadly considers the daily lives of the actors involved:children, one user of the system, and the health team. From the viewpoint of Occupational Therapy, with focuson the problems of the territory, interventions linking the following matters were proposed: individual care,collective care, and co-responsibility of the community and staff in pursuit of the resignificance of the everydaylives of the actors involved. This is a concrete example of paradigm shift from the existing health model to theprecepts of the Family Health Strategy, with the involvement of users and professionals from various areas.The occupational therapist identified different demands of the territory: the need for transformation of dailylife and routine of a user; the need for children’s leisure; and the desire of the health team to build this spacethrough a playroom. The possible combination of the user, children and the team’s everyday realities composedan intervention project based on the vision of the clinic expanded. The “playing and storytelling” was able toactually transform the health care model.

  13. Experiences of Social Inclusion and Employment of Mental Health Service Users in a European Union Project

    DEFF Research Database (Denmark)

    Nieminen, Irja; Ramon, Shulamit; Dawson, Ian;

    2012-01-01

    users experienced improvement in their social life. Employment and participation in meaningful activities continued to improve to the end of the EMILIA project, although at a slower pace. In addition, users were motivated for work and actively searched for employment. Having a mental illness, stigma......ABSTRACT: Aims: The aim of this study is to describe how the mental health service users experienced social inclusion and employment in the EU EMILIA project. Methods: The study design is an intervention group follow-up study, with data collection at three points: baseline (T0), at 10-month follow......-up (T1), and at 20-month follow-up (T2). The data for this study were collected with thematic in- terviews from mental health service users and were thematic analyzed with content analysis. The number of participants was 23 including two to four service users per each demonstration site. Results: Most...

  14. Health transformation project and defensive medicine practice among neurosurgeons in Turkey

    OpenAIRE

    Ihsan Solaroglu; Yusuf Izci; H Gokce Yeter; M Mert Metin; G Evren Keles

    2014-01-01

    Health Transformation Project and Defensive Medicine Practice among Neurosurgeons in Turkey Ihsan Solaroglu1*, Yusuf Izci2, H. Gokce Yeter3, M. Mert Metin3, G. Evren Keles1 1 Koc¸ University, School of Medicine, Department of Neurosurgery, Istanbul, Turkey, 2 Gulhane Military Medical Academy, School of Medicine, Department of Neurosurgery, Ankara, Turkey, 3 Koc¸ University, School of Medicine, Istanbul, Turkey Abstract Background: The term ‘‘Defensive’’ medicine was coined i...

  15. Outcomes of a Bystander Intervention Community Health Service-Learning Project.

    Science.gov (United States)

    Decker, Kim; Hensel, Desiree; Fasone, Leslie

    2016-01-01

    The purpose of this article is to describe the integration of a college bystander intervention service-learning project into an entry-level community clinical course in a prelicensure program and its outcomes. Two years of data from 118 students showed that students helped improve campus safety while growing as professionals and gaining leadership and health promotion skills. Approximately one-third of the students described a specific incident in which they intervened in an ambiguous situation. PMID:26633150

  16. The Health Intervention Project: HIV risk reduction among African American women drug users.

    OpenAIRE

    Sterk, Claire E.

    2002-01-01

    OBJECTIVE: This article describes the Health Intervention Project, an intervention for African American women in Atlanta, Georgia, who are crack cocaine users. METHODS:A formative phase involved ethnographic mapping of the physical and social infrastructure of the study communities and in-depth interviews with women crack cocaine users. Key findings that were incorporated into the intervention program included the exchange of sex for money or drugs, the women's experience with trauma and abus...

  17. Target audience penetration by a healthy lifestyle promotion programme: results from the Kilkenny Health Project

    OpenAIRE

    Murray, Peter; Shelley, Emer; Daly, Leslie; Collins, Claire; Conroy, Ronan; Graham, Ian

    1995-01-01

    Between 1985 and 1992 County Kilkenny was the site of an evaluated programme of community intervention which aimed to reduce the population's heart disease burden by promoting the adoption of a healthy lifestyle. This paper analyses data on public awareness of the Kilkenny Health Project's activities collected in a 1990-91 evaluation survey. The implications of the findings for healthy lifestyle promotion programmes supporting the achievement of the targets set in the recently unveiled ...

  18. Assessment of Cost Impact in Health and Safety on Construction Projects

    OpenAIRE

    Bima Abubakar Muhammad; Ismaila Abdulateef; Baba Dorothy Ladi

    2015-01-01

    The study assesses the cost impact of Health and Safety management within the construction industry. The purpose of the study is to help identify the impact of cost directly to projects. Toward this end, a field survey was conducted with a sample of fifty contractors selected in a given geographical region with high density of construction work. Data were collected using structured questionnaires and analyzed using a tabular presentation identifying percentages of given responses. The resu...

  19. Remote health monitoring with wearable non-invasive mobile system: The HealthWear project.

    Science.gov (United States)

    Paradiso, R; Alonso, A; Cianflone, D; Milsis, A; Vavouras, T; Malliopoulos, C

    2008-01-01

    This paper focuses on the technical solutions enabling the monitoring of health conditions by means of ECG, HR, oxygen saturation, impedance pneumography and activity patterns. The Healthwear service is based on the Wealthy prototype system. A new design has been made to increase comfort in wearing of the system during daily patient activities. The cloth is connected to a patient portable electronic unit (PPU) that acquires and elaborates the signals from the sensors. The PPU transmits the signal to a central processing site through the use of GPRS wireless technology. This service is applied to three distinct clinical contexts: rehabilitation of cardiac patients, following an acute event; early discharge program in chronic respiration patients; promotion of physical activity in ambulatory stable cardio-respiratory patients.

  20. On the Season, a Report of a Public Health Project Conducted Among Negro Migrant Agricultural Workers in Palm Beach County, Florida.

    Science.gov (United States)

    Browning, Robert H.; Northcutt, Travis J., Jr.

    A 5-year project to develop public health services for migrant workers was initiated in Florida in 1956. The project staff consisted of 8 public health personnel: 2 public health nurses, a public health educator, a public health nutritionist, a medical social worker, a part-time sanitarian, a liaison worker, and a secretary. Two practicing…

  1. Phase behaviors and self-assembly properties of two catanionic surfactant systems: C(8)F(17)COOH/TTAOH/H(2)O and C(8)H(17)COOH/TTAOH/H(2)O.

    Science.gov (United States)

    Zhang, Juan; Song, Aixin; Li, Zhibo; Xu, Guiying; Hao, Jingcheng

    2010-10-21

    Two fatty acids, perfluorononanoic acid (C(8)F(17)COOH) and nonanoic acid (C(8)H(17)COOH), were mixed with a cationic hydrocarbon surfactant, tetradecyltrimethylammonium hydroxide (TTAOH), in aqueous solutions for comparative investigation. Phase behaviors of the two systems are quite different because of the special properties of the fluorocarbon chains. For the C(8)H(17)COOH/TTAOH/H(2)O system, a single L(α) phase region with phase transition from planar lamellar phase (L(αl) phase) to vesicle phase (L(αv) phase) was observed. For the C(8)F(17)COOH/TTAOH/H(2)O system, two single phases consisting of vesicles were obtained at room temperature. One is a high viscoelastic gel phase consisting of vesicles with crystalline state bialyers at the C(8)F(17)COOH-rich side, which was confirmed by freeze-fracture transmission electron microscope (FF-TEM) and differential scanning calorimetry (DSC) measurements. With the increase of TTAOH proportion, another vesicle phase consisting of liquid state bilayers was observed after the two-phase region. The fluorosurfactant systems prefer to form vesicle bilayers than the corresponding hydrocarbon ones because of the rigid structure, the stronger hydrophobicity, and the larger volume of fluorocarbon chains.

  2. An Evaluation Framework for EU Research and Development e-Health Projects' Systems

    Science.gov (United States)

    Mavridis, Androklis; Katriou, Stamatia-Ann; Koumpis, Adamantios

    Over the past years it has become evident that an evaluation system was necessary for the European Research and Competitive funded projects which are large and complex structures needing constant monitoring. This is especially so for e-Health projects. The race to complete assignments means that this area is usually neglected. A proposed framework for the evaluation of R & D project systems using ATAM, ISO 14598 and ISO 9126 standards is presented. The evaluation framework covers a series of steps which ensures that the offered system satisfies quality, attributes such as operability, usability and maintainability imposed by the end users. The main advantage of this step by step procedure is that faults in the architecture, software or prototype can be recognised early in the development phase and corrected more rapidly. The system has a common set of attributes against which the various project’s deliverables are assessed.

  3. Projection models for health-effects assessment in populations exposed to radioactive and nonradioactive pollutants. Volume I. Introduction to the SPAHR demographic model for health risk

    International Nuclear Information System (INIS)

    The Simulation Package for the Analysis of Health Risk (SPAHR) is a computer software package based upon a demographic model for health risk projections. The model extends several health risk projection models by making realistic assumptions about the population at risk, and thus represents a distinct improvement over previous models. Complete documentation for use of SPAHR is contained in this five-volume publication. The demographic model in SPAHR estimates population response to environmental toxic exposures. Latency of response, changing dose level over time, competing risks from other causes of death, and population structure can be incorporated into SPAHR to project health risks. Risks are measured by morbid years, number of deaths, and loss of life expectancy. Comparisons of estimates of excess deaths demonstrate that previous health risk projection models may have underestimated excess deaths by a factor of from 2 to 10, depending on the pollutant and the exposure scenario. The software supporting the use of the demographic model is designed to be user oriented. Complex risk projections are made by responding to a series of prompts generated by the package. The flexibility and ease of use of SPAHR make it an important contribution to existing models and software packages. The first volume presents the theory behind the SPAHR health risk projection model and several applications of the model to actual pollution episodes. The elements required for an effective health risk projection model are specified, and the models that have been used to date in health risk projections are outlined. These are compared with the demographic model, whose formulation is described in detail. Examples of the application of air pollution and radiation dose-response functions are included in order to demonstrate the estimation of future mortality and morbidity levels and the range of variation in excess deaths that occurs when populations structure is changed

  4. Projection models for health-effects assessment in populations exposed to radioactive and nonradioactive pollutants. Volume I. Introduction to the SPAHR demographic model for health risk

    Energy Technology Data Exchange (ETDEWEB)

    Collins, J.J.; Lundy, R.T.; Grahn, D.; Ginevan, M.E.

    1982-09-01

    The Simulation Package for the Analysis of Health Risk (SPAHR) is a computer software package based upon a demographic model for health risk projections. The model extends several health risk projection models by making realistic assumptions about the population at risk, and thus represents a distinct improvement over previous models. Complete documentation for use of SPAHR is contained in this five-volume publication. The demographic model in SPAHR estimates population response to environmental toxic exposures. Latency of response, changing dose level over time, competing risks from other causes of death, and population structure can be incorporated into SPAHR to project health risks. Risks are measured by morbid years, number of deaths, and loss of life expectancy. Comparisons of estimates of excess deaths demonstrate that previous health risk projection models may have underestimated excess deaths by a factor of from 2 to 10, depending on the pollutant and the exposure scenario. The software supporting the use of the demographic model is designed to be user oriented. Complex risk projections are made by responding to a series of prompts generated by the package. The flexibility and ease of use of SPAHR make it an important contribution to existing models and software packages. The first volume presents the theory behind the SPAHR health risk projection model and several applications of the model to actual pollution episodes. The elements required for an effective health risk projection model are specified, and the models that have been used to date in health risk projections are outlined. These are compared with the demographic model, whose formulation is described in detail. Examples of the application of air pollution and radiation dose-response functions are included in order to demonstrate the estimation of future mortality and morbidity levels and the range of variation in excess deaths that occurs when populations structure is changed.

  5. Medico-ecological study and health impact assessment of hydro-electric projects in Malaysia

    International Nuclear Information System (INIS)

    The objectives of this studies were to determine i) if there was any potential health risks in terms of spread of vector-borne and other communicable diseases resulting from the changes in the environment due to creation of large bodies of water as consequence of the construction of dams, ii) diseases of public health importance in populations affected by such projects. Nine pre-impoundment studies had been carried out and potential impact of the change in environment on discases and health of the affected populations in each areas was evaluated. Risk of infections to the dam construction workers also assessed. Recommendations on mitigation measures were made for each situation so that adequate provisions could be made to improve the health conditions of these populations especially those who would be resettled as a result of impoundment . Prevention and control measures on transmission of infection, including vector control were proposed. The potential medico-ecological hazards encountered by immigrants and visitors to the area on completion of the hydro project were also envisaged

  6. Competency-based project to review community/public health curricula.

    Science.gov (United States)

    Schoneman, Doris; Simandl, Gladys; Hansen, Judith M; Garrett, Sharon

    2014-01-01

    Changes in the delivery of community/public health (C/PH) nursing have challenged nursing educators to seek innovative ways to ensure that their educational programs produce competent entry-level practitioners. This article describes how public health professionals and faculty from eight regional colleges and universities in Southeastern Wisconsin came together to better understand both what C/PH nursing content was being taught in the region, and the extent to which that content was aligned with the Public Health Nurse Competencies defined by the Quad Council in 2004. Based on self-reporting by nursing school faculty as well as a separate mapping of course objectives into the competency areas, the project found that the curricula of the participating colleges and universities adequately addressed most of the competencies in the Quad Council domains one through six. Competencies in domains seven (financial planning/management skills) and eight (leadership/systems thinking skills) were not, however, adequately addressed and plans were subsequently developed to fill those gaps. In addition to helping each institution identify strengths and gaps in its own curriculum, the project provided an unprecedented opportunity for both public health professionals and academics to build relationships, share best practices, and exchange resources. PMID:24304141

  7. Competency-based project to review community/public health curricula.

    Science.gov (United States)

    Schoneman, Doris; Simandl, Gladys; Hansen, Judith M; Garrett, Sharon

    2014-01-01

    Changes in the delivery of community/public health (C/PH) nursing have challenged nursing educators to seek innovative ways to ensure that their educational programs produce competent entry-level practitioners. This article describes how public health professionals and faculty from eight regional colleges and universities in Southeastern Wisconsin came together to better understand both what C/PH nursing content was being taught in the region, and the extent to which that content was aligned with the Public Health Nurse Competencies defined by the Quad Council in 2004. Based on self-reporting by nursing school faculty as well as a separate mapping of course objectives into the competency areas, the project found that the curricula of the participating colleges and universities adequately addressed most of the competencies in the Quad Council domains one through six. Competencies in domains seven (financial planning/management skills) and eight (leadership/systems thinking skills) were not, however, adequately addressed and plans were subsequently developed to fill those gaps. In addition to helping each institution identify strengths and gaps in its own curriculum, the project provided an unprecedented opportunity for both public health professionals and academics to build relationships, share best practices, and exchange resources.

  8. Effects of primary grades health curriculum project on student and parent smoking attitudes and behavior.

    Science.gov (United States)

    Andrews, R L; Hearne, J T

    1984-01-01

    Family values regarding appropriate attitudes and behaviors are communicated to children from birth. Society's values begin to affect the child at an early age and as these change, so do children's beliefs and attitudes. A change in society's values toward smoking has been evidenced in the last decade by increased social sanctions against smoking and increased militancy of nonsmokers. This longitudinal Primary Grades Health Curriculum Project investigates the relationship between an activity-centered experiential health education program and: 1) positive health attitudes; 2) experimentation use and future expectancy to engage in cigarette smoking; and 3) changes in smoking behavior among the children's parents. Six hundred students in two New York school districts were pretested in their kindergarten year in 1977 on entry level of knowledge and attitudes about health. The results reported here from data collected at the end of third grade indicate that the experimental group possessed more positive attitudes about health, showed less exposure to experimentation with alcohol among their friends and less engagement in smoking cigarettes. A significant number of parents of experimental group students reported that they had changed their smoking habits since their child had entered school as a result of their children's health program. PMID:6560127

  9. NASA Human Health and Performance Center: Open Innovation Successes and Collaborative Projects

    Science.gov (United States)

    Davis, Jeffrey R.; Richard, Elizabeth E.

    2014-01-01

    In May 2007, what was then the Space Life Sciences Directorate published the 2007 Space Life Sciences Strategy for Human Space Exploration, which resulted in the development and implementation of new business models and significant advances in external collaboration over the next five years. The strategy was updated on the basis of these accomplishments and reissued as the NASA Human Health and Performance Strategy in 2012, and continues to drive new approaches to innovation for the directorate. This short paper describes the open innovation successes and collaborative projects developed over this timeframe, including the efforts of the NASA Human Health and Performance Center (NHHPC), which was established to advance human health and performance innovations for spaceflight and societal benefit via collaboration in new markets.

  10. Sexual health of ethnic minority MSM in Britain (MESH project: design and methods

    Directory of Open Access Journals (Sweden)

    Low Nicola

    2010-07-01

    Full Text Available Abstract Background Men who have sex with men (MSM remain the group most at risk of acquiring HIV infection in Britain. HIV prevalence appears to vary widely between MSM from different ethnic minority groups in this country for reasons that are not fully understood. The aim of the MESH project was to examine in detail the sexual health of ethnic minority MSM living in Britain. Methods/Design The main objectives of the MESH project were to explore among ethnic minority MSM living in Britain: (i sexual risk behaviour and HIV prevalence; (ii their experience of stigma and discrimination; (iii disclosure of sexuality; (iv use of, and satisfaction with sexual health services; (v the extent to which sexual health services (for treatment and prevention are aware of the needs of ethnic minority MSM. The research was conducted between 2006 and 2008 in four national samples: (i ethnic minority MSM living in Britain; (ii a comparison group of white British MSM living in Britain; (iii NHS sexual health clinic staff in 15 British towns and cities with significant ethnic minority communities and; (iv sexual health promotion/HIV prevention service providers. We also recruited men from two "key migrant" groups living in Britain: MSM born in Central or Eastern Europe and MSM born in Central or South America. Internet-based quantitative and qualitative research methods were used. Ethnic minority MSM were recruited through advertisements on websites, in community venues, via informal networks and in sexual health clinics. White and "key migrant" MSM were recruited mostly through Gaydar, one of the most popular dating sites used by gay men in Britain. MSM who agreed to take part completed a questionnaire online. Ethnic minority MSM who completed the online questionnaire were asked if they would be willing to take part in an online qualitative interview using email. Service providers were identified through the British Association of Sexual Health and HIV (BASHH and

  11. Assessing health impacts of the Chad-Cameroon petroleum development and pipeline project: challenges and a way forward

    International Nuclear Information System (INIS)

    Health impact assessment (HIA) of projects, programmes and policies is increasingly recognized as a powerful methodology for mitigating negative health impacts and enhancing equitable and sustainable development, yet applications in the developing world are sparse. Here, we focus on a large infrastructure development in sub-Saharan Africa, namely the Chad-Cameroon petroleum development and pipeline project. We adapted a five-step process for HIA, consisting of (1) screening of project documents, (2) profiling of affected communities, (3) identifying priority health areas, predicting potential impacts, and proposing mitigation measures, (4) implementing interventions, and (5) monitoring and evaluation of health impacts. We found that project scoping was broad, including extensive environmental and social assessments. Innovative features of the project include the high degree of public-private partnerships, and the management of oil revenues for purposes of poverty reduction. The project also addressed occupational and public health issues, and developed and implemented measures to prevent or mitigate potential health impacts. However, there was a disproportionate emphasis on workers' health, particularly on the prevention/mitigation of construction-related injuries, sexually transmitted infections (STIs; mainly HIV/AIDS), and malaria. Health impacts among surrounding communities, and cumulative health impacts in the larger region were not considered in a comprehensive way. Concluding, there is a need for a more systemic approach to HIA and its incorporation within 'Equator Principles', which are increasingly adopted by the international financial community. This process would include clarification of corporate social responsibility beyond the project fence line in the mitigation of health problems at regional levels. Finally, we propose the establishment and running of a longitudinal demographic surveillance system, which--coupled with regular household surveys

  12. High-Resolution Infrared Spectroscopy of Cubane, C_8H_8

    Science.gov (United States)

    Boudon, Vincent; Pirali, Olivier; Gruet, Sébastien; D'accolti, Lucia; Fusco, Caterina; Annese, Cosimo

    2014-06-01

    Carbon-cage molecules have generated a considerable interest from both experimental and theoretical point of views. We recently performed a high-resolution study of adamantane (C10H16), the smallest hydrocarbon cage belonging to the diamandoid family. There exist another family of hydrocarbon cages with additional interesting chemical properties: the so-called Platonic hydrocarbons that comprise dodecahedrane (C20H20) and cubane (C_8H_8). Both possess C-C bond angles that deviate from the tetrahedral angle (109.8°) of the sp^3 hybridized form of carbon. This generates a considerable strain in the molecule. Cubane itself has the highest density of all hydrocarbons (1.29 g/cm^3). This makes it able to store larges amounts of energy, although the molecule is fully stable. Up to now, only one high-resolution study of cubane has been performed on a few bands [2]. We report here a new wide-range high-resolution study of the infrared spectrum of cubane. The sample was synthesized in Bari upon decarboxylation of 1,4-cubanedicarboxylic acid thanks to the improved synthesis of literature [3]; its {}1H and 13C NMR, FTIR, and mass spectrometry agreed with reported data [4]. Several spectra have been recorded at the AILES beamline of the SOLEIL French synchrotron facility. They cover the 800 to 3100 cm-1 region. Besides the three infrared-active fundamentals (ν10, ν11 and ν12), we could record many combination bands, all of them displaying a well-resolved octahedral rotational structure. We present here a preliminary analysis of some of the recorded bands, performed thanks the SPVIEW and XTDS software, based on the tensrorial formalism developed in the Dijon group [5]. [1] O. Pirali, V. Boudon, J. Oomens, M. Vervloet, J. Chem. Phys., 136, 024310 (2012). [2] A. S. Pine, A. G. Maki, A. G. Robiette, B. J. Krohn, J. K. G. Watson, Th. Urbanek, J. Am. Chem. Soc., 106, 891-897 (1984). [3] P. E. Eaton, N. Nordari, J. Tsanaktsidis, P. S. Upadhyaya, Synthesis, 1, 501, (1995). [4] E

  13. Breckinridge Project, initial effort. Report VII, Volume 4. Safety and health plan

    Energy Technology Data Exchange (ETDEWEB)

    None

    1982-01-01

    The Safety and Health Plan recognizes the potential hazards associated with the Project and has been developed specifically to respond to these risks in a positive manner. Prevention, the primary objective of the Plan, starts with building safety controls into the process design and continues through engineering, construction, start-up, and operation of the Project facilities and equipment. Compliance with applicable federal, state, and local health and safety laws, regulations, and codes throughout all Project phases is required and assured. The Plan requires that each major Project phase be thoroughly reviewed and analyzed to determine that those provisions required to assure the safety and health of all employees and the public, and to prevent property and equipment losses, have been provided. The Plan requires followup on those items or situations where corrective action needs were identified to assure that the action was taken and is effective. Emphasis is placed on loss prevention. Exhibit 1 provides a breakdown of Ashland Synthetic Fuels, Inc.'s (ASFI's) Loss Prevention Program. The Plan recognizes that the varied nature of the work is such as to require the services of skilled, trained, and responsible personnel who are aware of the hazards and know that the work can be done safely, if done correctly. Good operating practice is likewise safe operating practice. Training is provided to familiarize personnel with good operational practice, the general sequence of activities, reporting requirements, and above all, the concept that each step in the operating procedures must be successfully concluded before the following step can be safely initiated. The Plan provides for periodic review and evaluation of all safety and loss prevention activities at the plant and departmental levels.

  14. Healthy Hearts at work: Prince Edward Island Heart Health Program CSC worksite pilot project.

    Science.gov (United States)

    Herbert, R; White, R

    1996-01-01

    Prince Edward Island experiences a higher-than-average death rate from cardiovascular disease. The Prince Edward Island Heart Health Program is a health promotion/disease prevention research project of Health Canada and the Prince Edward Island Department of Health and Social Services. This paper describes and evaluates a worksite program, based on the principles of community mobilization, that was initiated with the Civil Service Commission of the Prince Edward Island government. The building of a partnership, the risk appraisal session administered in the workplace, the establishment of an Employee Wellness Committee, and subsequent programming which has occurred in the workplace were the key components in the process. Collaboration with the partner agency and participation of employees in the planning process has resulted in the delivery of programs which could not have been achieved by one of the agencies alone, without many additional resources. It is hoped that these characteristics of collaboration and employee participation will also result in sustainability of this initiative when PEI Heart Health is no longer involved. PMID:8900810

  15. Health Promotion in an Opioid Treatment Program: An Evidence-Based Nursing Quality Improvement Project.

    Science.gov (United States)

    Gadbois, Christine; Chin, Elizabeth D; Dalphonse, Lee

    2016-01-01

    Community assessment and review of the literature indicate that individuals supported in opioid treatment programs are at a significant disadvantage for access to preventative and primary healthcare. In addition, this population faces increased comorbidities and chronic disease. Finally, access to housing, nutritious food, and other social determinants of health is also a challenge for these individuals. This project, aimed at addressing healthcare disparities and improving health outcomes for the opioid treatment program client, was undertaken at a large, private, not-for-profit, community mental health center in an urban area. An education-practice partnership was created between the center and the local university's College of Nursing, which includes undergraduate and graduate programs. Working with administration, nurses, medical staff, and clinicians, the advanced practice nurse guided nursing practice change within the context of an interdisciplinary team to increase attention to clients' health needs. Outcomes included a more comprehensive nursing health assessment and increased attention to nursing care coordination. The partnership between the university and the facility continues with the goal of addressing clients' unmet healthcare needs and improving wellness via on-site intervention, referral, and education. PMID:27272997

  16. The Jailbreak Health Project--incorporating a unique radio programme for prisoners.

    Science.gov (United States)

    Minc, Ariane; Butler, Tony; Gahan, Gary

    2007-10-01

    Several studies in NSW have identified prisoners to be at high risk for blood borne viruses. The prevalence of hepatitis C among men in NSW correctional centres is 40% and over 60% among women. It is even higher among those with histories of injecting drug use. As part of the state's strategy to minimise the spread of blood borne viruses and promote healthy lifestyles among prisoners, the Community Restorative Centre broadcasts a weekly half hour radio programme to prisoners and the community. The project is funded through the NSW Health Department and aims to provide support to prisoners, ex-prisoners and their families. Jailbreak's success hinges on the participation of the very people [prisoners] the show wishes to target. The radio show is aimed specifically at broadcasting health promotion and harm-minimisation messages to prisoners and their supporters although this is not obvious. When you tune in to Jailbreak you will hear a diverse range of opinion, music and poetry from people caught up in the criminal justice system. Nevertheless at the heart of this exciting and challenging project is the delivery of engaging, relevant and clear health messages to prison inmates, ex-inmates and families in relation to HIV, hepatitis and sexual health. Since 2002, valuable health information, often in the form of personal stories, vignettes and quiz questions, can be heard in and around Sydney on 2SER 107.3 FM or online at http://www.2ser.com. Jailbreak has not been without controversy and has to balance the security focus of correctional authorities and the illegality of substance use in correctional centres with the need to convey messages to prisoners in relation to harm-minimisation. PMID:17854735

  17. Community health outreach program of the Chad-Cameroon petroleum development and pipeline project.

    Science.gov (United States)

    Utzinger, Jürg; Wyss, Kaspar; Moto, Daugla D; Tanner, Marcel; Singer, Burton H

    2004-02-01

    A critical appraisal has been presented of the CHOP for a large-scale energy infrastructure development project that was implemented in two of the world's poorest countries. The project is under close scrutiny from various independent monitoring groups, civil society organizations, and human rights groups. Reviewing the achievements and shortcomings permits the extraction of important lessons that will be critical for the future adoption of the CHOP in the current setting and for the implementation of additional CHOPs elsewhere in the developing world. The authors believe that the design must be flexible, efficient, and innovative so that a CHOP promptly can address pressing public health issues as they arise (eg, epidemic outbreak) and include the needs and demands of the concerned communities. An innovative feature of the current project is the high degree and mix of public-private partnerships. The project's CHOP also relies on partnerships. As elaborated elsewhere, public-private partnerships should be seen as a social experiment--they reveal promise but are not the solution for every problem. For this CHOP, the focus is on partnerships between a multinational consortium, government agencies, and international organizations. The partnerships also include civil society organizations for monitoring and evaluation and local NGOs designated for the implementation of the selected public health interventions within the CHOP. The governments and their respective health policies often form the umbrella under which the partnerships operate. With the increase in globalization, however, the importance and capacities of governments have diminished, and there is growing private-sector involvement. Private enterprise is seen as an efficient, innovative, pragmatic, and powerful means to achieve environmental and social sustainability. Experiences with the partnership configurations in the current CHOP are of importance for tackling grand challenges in global health by

  18. Community health outreach program of the Chad-Cameroon petroleum development and pipeline project.

    Science.gov (United States)

    Utzinger, Jürg; Wyss, Kaspar; Moto, Daugla D; Tanner, Marcel; Singer, Burton H

    2004-02-01

    A critical appraisal has been presented of the CHOP for a large-scale energy infrastructure development project that was implemented in two of the world's poorest countries. The project is under close scrutiny from various independent monitoring groups, civil society organizations, and human rights groups. Reviewing the achievements and shortcomings permits the extraction of important lessons that will be critical for the future adoption of the CHOP in the current setting and for the implementation of additional CHOPs elsewhere in the developing world. The authors believe that the design must be flexible, efficient, and innovative so that a CHOP promptly can address pressing public health issues as they arise (eg, epidemic outbreak) and include the needs and demands of the concerned communities. An innovative feature of the current project is the high degree and mix of public-private partnerships. The project's CHOP also relies on partnerships. As elaborated elsewhere, public-private partnerships should be seen as a social experiment--they reveal promise but are not the solution for every problem. For this CHOP, the focus is on partnerships between a multinational consortium, government agencies, and international organizations. The partnerships also include civil society organizations for monitoring and evaluation and local NGOs designated for the implementation of the selected public health interventions within the CHOP. The governments and their respective health policies often form the umbrella under which the partnerships operate. With the increase in globalization, however, the importance and capacities of governments have diminished, and there is growing private-sector involvement. Private enterprise is seen as an efficient, innovative, pragmatic, and powerful means to achieve environmental and social sustainability. Experiences with the partnership configurations in the current CHOP are of importance for tackling grand challenges in global health by

  19. Health and Environment Linked for Information Exchange (HELIX)-Atlanta: A CDC-NASA Joint Environmental Public Health Tracking Collaborative Project

    Science.gov (United States)

    Al-Hamdan, Mohammad; Luvall, Jeff; Crosson, Bill; Estes, Maury; Limaye, Ashutosh; Quattrochi, Dale; Rickman, Doug

    2008-01-01

    HELIX-Atlanta was developed to support current and future state and local EPHT programs to implement data linking demonstration projects which could be part of the CDC EPHT Network. HELIX-Atlanta is a pilot linking project in Atlanta for CDC to learn about the challenges the states will encounter. NASA/MSFC and the CDC are partners in linking environmental and health data to enhance public health surveillance. The use of NASA technology creates value added geospatial products from existing environmental data sources to facilitate public health linkages. Proving the feasibility of the approach is the main objective

  20. Digital patient: Personalized and translational data management through the MyHealthAvatar EU project.

    Science.gov (United States)

    Kondylakis, Haridimos; Spanakis, Emmanouil G; Sfakianakis, Stelios; Sakkalis, Vangelis; Tsiknakis, Manolis; Marias, Kostas; Xia Zhao; Hong Qing Yu; Feng Dong

    2015-08-01

    The advancements in healthcare practice have brought to the fore the need for flexible access to health-related information and created an ever-growing demand for the design and the development of data management infrastructures for translational and personalized medicine. In this paper, we present the data management solution implemented for the MyHealthAvatar EU research project, a project that attempts to create a digital representation of a patient's health status. The platform is capable of aggregating several knowledge sources relevant for the provision of individualized personal services. To this end, state of the art technologies are exploited, such as ontologies to model all available information, semantic integration to enable data and query translation and a variety of linking services to allow connecting to external sources. All original information is stored in a NoSQL database for reasons of efficiency and fault tolerance. Then it is semantically uplifted through a semantic warehouse which enables efficient access to it. All different technologies are combined to create a novel web-based platform allowing seamless user interaction through APIs that support personalized, granular and secure access to the relevant information. PMID:26736530

  1. Digital patient: Personalized and translational data management through the MyHealthAvatar EU project.

    Science.gov (United States)

    Kondylakis, Haridimos; Spanakis, Emmanouil G; Sfakianakis, Stelios; Sakkalis, Vangelis; Tsiknakis, Manolis; Marias, Kostas; Xia Zhao; Hong Qing Yu; Feng Dong

    2015-08-01

    The advancements in healthcare practice have brought to the fore the need for flexible access to health-related information and created an ever-growing demand for the design and the development of data management infrastructures for translational and personalized medicine. In this paper, we present the data management solution implemented for the MyHealthAvatar EU research project, a project that attempts to create a digital representation of a patient's health status. The platform is capable of aggregating several knowledge sources relevant for the provision of individualized personal services. To this end, state of the art technologies are exploited, such as ontologies to model all available information, semantic integration to enable data and query translation and a variety of linking services to allow connecting to external sources. All original information is stored in a NoSQL database for reasons of efficiency and fault tolerance. Then it is semantically uplifted through a semantic warehouse which enables efficient access to it. All different technologies are combined to create a novel web-based platform allowing seamless user interaction through APIs that support personalized, granular and secure access to the relevant information.

  2. Public health impacts of city policies to reduce climate change:Findings from the URGENCHE EU-China project

    OpenAIRE

    Clive E. Sabel; Hiscock, Rosemary; Asikainen, Arja; Bi, Jun; Depledge, Mike; Van Den Elshout, Sef; Friedrich, Rainer; Huang, Ganlin; Hurley, Fintan; Jantunen, Matti; Karakitsios, Spyros P.; Keuken, Menno; Kingham, Simon; Kontoroupis, Periklis; Kuenzli, Nino

    2016-01-01

    Background: Climate change is a global threat to health and wellbeing. Here we provide findings of an international research project investigating the health and wellbeing impacts of policies to reduce greenhouse gas emissions in urban environments.Methods: Five European and two Chinese city authorities and partner academic organisations formed the project consortium. The methodology involved modelling the impact of adopted urban climate-change mitigation transport, buildings and energy polic...

  3. Extending Occupational Health and Safety to Urban Street Vendors: Reflections From a Project in Durban, South Africa.

    Science.gov (United States)

    Alfers, Laura; Xulu, Phumzile; Dobson, Richard; Hariparsad, Sujatha

    2016-08-01

    This article focuses on an action-research project which is attempting to extend occupational health and safety to a group of street traders in Durban, South Africa, using a variety of different (and sometimes unconventional) institutional actors. The article is written from the perspective of key people who have played a role in conceptualizing and administering the project and is intended to deepen the conversation about what it means to extend occupational health to the informal economy. It explores this question through a reflection on three key project activities: the setting up of a trader-led health and safety committee, an occupational health and safety training course, and a clinical health assessment. It concludes with a discussion of the issues that emerge from the reflections of project participants, which include the need to bring occupational health and urban health into closer conversation with one another, the need to be cognizant of local "informal" politics and the impact that has on occupational health and safety interventions, and the need to create greater opportunities for occupational health and safety professionals to interact with workers in the informal economy. PMID:27406111

  4. National Health Expenditure Projections, 2015-25: Economy, Prices, And Aging Expected To Shape Spending And Enrollment.

    Science.gov (United States)

    Keehan, Sean P; Poisal, John A; Cuckler, Gigi A; Sisko, Andrea M; Smith, Sheila D; Madison, Andrew J; Stone, Devin A; Wolfe, Christian J; Lizonitz, Joseph M

    2016-08-01

    Health spending growth in the United States for 2015-25 is projected to average 5.8 percent-1.3 percentage points faster than growth in the gross domestic product-and to represent 20.1 percent of the total economy by 2025. As the initial impacts associated with the Affordable Care Act's coverage expansions fade, growth in health spending is expected to be influenced by changes in economic growth, faster growth in medical prices, and population aging. Projected national health spending growth, though faster than observed in the recent history, is slower than in the two decades before the recent Great Recession, in part because of trends such as increasing cost sharing in private health insurance plans and various Medicare payment update provisions. In addition, the share of total health expenditures paid for by federal, state, and local governments is projected to increase to 47 percent by 2025.

  5. Projections of specialist physicians in Mexico: a key element in planning human resources for health.

    Science.gov (United States)

    Nigenda, Gustavo; Muños, José Alberto

    2015-01-01

    Projections are considered a useful tool in the planning of human resources for health. In Mexico, the supply and demand of specialist doctors are clearly disconnected, and decisions must be made to reduce labour market imbalances. Thus, it is critical to produce reliable projections to assess future interactions between supply and demand. Using a service demand approach, projections of the number of specialist physicians required by the three main public institutions were calculated using the following variables: a) recent recruitment of specialists, b) physician productivity and c) retirement rates. Two types of scenarios were produced: an inertial one with no changes made to current production levels and an alternative scenario adjusted by recommended productivity levels. Results show that institutions must address productivity as a major policy element to act upon in future contracting of specialist physicians. The projections that adjusted for productivity suggest that the hiring trends for surgeons and internists should be maintained or increased to compensate for the increase in demand for services. In contrast, due to the decline in demand for obstetric and paediatric services, the hiring of new obstetrician-gynaecologists and paediatricians should be reduced to align with future demand. PMID:26391878

  6. Projections of specialist physicians in Mexico: a key element in planning human resources for health.

    Science.gov (United States)

    Nigenda, Gustavo; Muños, José Alberto

    2015-09-22

    Projections are considered a useful tool in the planning of human resources for health. In Mexico, the supply and demand of specialist doctors are clearly disconnected, and decisions must be made to reduce labour market imbalances. Thus, it is critical to produce reliable projections to assess future interactions between supply and demand. Using a service demand approach, projections of the number of specialist physicians required by the three main public institutions were calculated using the following variables: a) recent recruitment of specialists, b) physician productivity and c) retirement rates. Two types of scenarios were produced: an inertial one with no changes made to current production levels and an alternative scenario adjusted by recommended productivity levels. Results show that institutions must address productivity as a major policy element to act upon in future contracting of specialist physicians. The projections that adjusted for productivity suggest that the hiring trends for surgeons and internists should be maintained or increased to compensate for the increase in demand for services. In contrast, due to the decline in demand for obstetric and paediatric services, the hiring of new obstetrician-gynaecologists and paediatricians should be reduced to align with future demand.

  7. Global emission estimates and radiative impact of C4F10, C5F12, C6F14, C7F16 and C8F18

    Science.gov (United States)

    Ivy, D. J.; Rigby, M.; Baasandorj, M.; Burkholder, J. B.; Prinn, R. G.

    2012-08-01

    estimated in this study. In addition, we present measured infrared absorption spectra for C7F16 and C8F18, and estimate their radiative efficiencies and global warming potentials (GWPs). We find that C8F18's radiative efficiency is similar to trifluoromethyl sulfur pentafluoride's (SF5F3) at 0.57 W m-2 ppb-1, which is the highest radiative efficiency of any measured atmospheric species. Using the 100-yr time horizon GWPs, the total radiative impact of the high molecular weight perfluorocarbons emissions are also estimated; we find the high molecular weight PFCs peak contribution was in 1997 at 24 000 Gg of carbon dioxide (CO2) equivalents and has decreased by a factor of three to 7300 Gg of CO2 equivalents in 2010. This 2010 cumulative emission rate for the high molecular weight PFCs is comparable to: 0.02% of the total CO2 emissions, 0.81% of the total hydrofluorocarbon emissions, or 1.07% of the total chlorofluorocarbon emissions projected for 2010 (Velders et al., 2009). In terms of the total PFC emission budget, including the lower molecular weight PFCs, the high molecular weight PFCs peak contribution was also in 1997 at 15.4% and was 6% of the total PFC emissions in CO2 equivalents in 2009.

  8. A Data Model for Integrating Heterogeneous Medical Data in the Health-e-Child Project

    CERN Document Server

    Branson, Andrew; McClatchey, Richard; Rogulin, Dmitry; Shamdasani, Jetendr

    2008-01-01

    There has been much research activity in recent times about providing the data infrastructures needed for the provision of personalised healthcare. In particular the requirement of integrating multiple, potentially distributed, heterogeneous data sources in the medical domain for the use of clinicians has set challenging goals for the healthgrid community. The approach advocated in this paper surrounds the provision of an Integrated Data Model plus links to/from ontologies to homogenize biomedical (from genomic, through cellular, disease, patient and population-related) data in the context of the EC Framework 6 Health-e-Child project. Clinical requirements are identified, the design approach in constructing the model is detailed and the integrated model described in the context of examples taken from that project. Pointers are given to future work relating the model to medical ontologies and challenges to the use of fully integrated models and ontologies are identified.

  9. Effectiveness of an Adaptation of the Project Connect Health Systems Intervention: Youth and Clinic-Level Findings

    Science.gov (United States)

    Loosier, Penny S.; Doll, Shelli; Lepar, Danielle; Ward, Kristin; Gamble, Ginger; Dittus, Patricia J.

    2016-01-01

    Background: The Project Connect Health Systems Intervention (Project Connect) uses a systematic process of collecting community and healthcare infrastructure information to craft a referral guide highlighting local healthcare providers who provide high quality sexual and reproductive healthcare. Previous self-report data on healthcare usage…

  10. Integrated Vehicle Health Management Project-Modeling and Simulation for Wireless Sensor Applications

    Science.gov (United States)

    Wallett, Thomas M.; Mueller, Carl H.; Griner, James H., Jr.

    2009-01-01

    This paper describes the efforts in modeling and simulating electromagnetic transmission and reception as in a wireless sensor network through a realistic wing model for the Integrated Vehicle Health Management project at the Glenn Research Center. A computer model in a standard format for an S-3 Viking aircraft was obtained, converted to a Microwave Studio software format, and scaled to proper dimensions in Microwave Studio. The left wing portion of the model was used with two antenna models, one transmitting and one receiving, to simulate radio frequency transmission through the wing. Transmission and reception results were inconclusive.

  11. Resettling refugees and safeguarding their mental health: lessons learned from the Canadian Refugee Resettlement Project.

    Science.gov (United States)

    Beiser, Morton

    2009-12-01

    The Ryerson University Refugee Resettlement Project (RRP), a decade-long study of 1348 Southeast Asian refugees who came to Canada between 1979 and 1981, is one of the largest, most comprehensive and longest-lived investigations of refugee resettlement ever carried out. Knowledge gleaned from the RRP about research methodology, about the resettlement experience, about the social costs of resettling refugees, about factors that promote or hinder integration, about risk and protective factors for refugee mental health, and about the refugees' consumption of mental health and social services is summarized in the form of 18 "Lessons." The lessons are offered in order to encourage and stimulate further research, as well to suggest policy and practice innovations that could help make resettlement easier, less costly, more effective, and more humane.

  12. A practical guide to applying lean tools and management principles to health care improvement projects.

    Science.gov (United States)

    Simon, Ross W; Canacari, Elena G

    2012-01-01

    Manufacturing organizations have used Lean management principles for years to help eliminate waste, streamline processes, and cut costs. This pragmatic approach to structured problem solving can be applied to health care process improvement projects. Health care leaders can use a step-by-step approach to document processes and then identify problems and opportunities for improvement using a value stream process map. Leaders can help a team identify problems and root causes and consider additional problems associated with methods, materials, manpower, machinery, and the environment by using a cause-and-effect diagram. The team then can organize the problems identified into logical groups and prioritize the groups by impact and difficulty. Leaders must manage action items carefully to instill a sense of accountability in those tasked to complete the work. Finally, the team leaders must ensure that a plan is in place to hold the gains.

  13. Through Their Eyes: Lessons Learned Using Participatory Methods in Health Care Quality Improvement Projects.

    Science.gov (United States)

    Balbale, Salva N; Locatelli, Sara M; LaVela, Sherri L

    2016-08-01

    In this methodological article, we examine participatory methods in depth to demonstrate how these methods can be adopted for quality improvement (QI) projects in health care. We draw on existing literature and our QI initiatives in the Department of Veterans Affairs to discuss the application of photovoice and guided tours in QI efforts. We highlight lessons learned and several benefits of using participatory methods in this area. Using participatory methods, evaluators can engage patients, providers, and other stakeholders as partners to enhance care. Participant involvement helps yield actionable data that can be translated into improved care practices. Use of these methods also helps generate key insights to inform improvements that truly resonate with stakeholders. Using participatory methods is a valuable strategy to harness participant engagement and drive improvements that address individual needs. In applying these innovative methodologies, evaluators can transcend traditional approaches to uniquely support evaluations and improvements in health care. PMID:26667882

  14. Nonevent Stress Contributes to Mental Health Disparities Based on Sexual Orientation: Evidence From a Personal Projects Analysis

    OpenAIRE

    Frost, David M.; LeBlanc, Allen J.

    2014-01-01

    This study examined the role of nonevent stress—in the form of frustrated personal project pursuits in the arenas of relationships and work—as a contributing factor to mental health disparities between heterosexual and lesbian, gay, and bisexual (LGB) populations. A purposive sample of 431 LGB (55%) and heterosexually identified (45%) individuals living in the United States and Canada completed the Personal Project Inventory by describing and rating core personal projects they were pursuing. ...

  15. NASA Aircraft on ramp (Aerial view) Sides: (L) QSRA (R) C-8A AWJSRA - Back to Front: CV-990 (711)

    Science.gov (United States)

    1981-01-01

    NASA Aircraft on ramp (Aerial view) Sides: (L) QSRA (R) C-8A AWJSRA - Back to Front: CV-990 (711) C-141 KAO, CV-990 (712) Galileo, T-38, YO-3A, Lear Jet, X-14, U-2, OH-6, CH-47, SH-3G, RSRA, AH-1G, XV-15, UH-1H

  16. Inhibitory effect of six herbal extracts on CYP2C8 enzyme activity in human liver microsomes.

    Science.gov (United States)

    Albassam, Ahmed A; Mohamed, Mohamed-Eslam F; Frye, Reginald F

    2015-05-01

    1. Herbal supplements widely used in the US were screened for the potential to inhibit CYP2C8 activity in human liver microsomes. The herbal extracts screened were garlic, echinacea, saw palmetto, valerian, black cohosh and cranberry. N-desethylamodiaquine (DEAQ) and hydroxypioglitazone metabolite formation were used as indices of CYP2C8 activity. 2. All herbal extracts showed inhibition of CYP2C8 activity for at least one of three concentrations tested. A volume per dose index (VDI) was calculated to determine the volume in which a dose should be diluted to obtain IC50 equivalent concentration. Cranberry and saw palmetto had a VDI value > 5.0 l per dose unit, suggesting a potential for interaction. 3. Inhibition curves were constructed and the IC50 (mean ± SE) values were 24.7 ± 2.7 μg/ml for cranberry and 15.4 ± 1.7 μg/ml for saw palmetto. 4. The results suggest a potential for cranberry or saw palmetto extracts to inhibit CYP2C8 activity. Clinical studies are needed to evaluate the significance of this interaction. PMID:25430798

  17. HEALTH-SCREENING PROTOCOLS FOR VINACEOUS AMAZONS (AMAZONA VINACEA) IN A REINTRODUCTION PROJECT.

    Science.gov (United States)

    Saidenberg, André B S; Zuniga, Eveline; Melville, Priscilla A; Salaberry, Sandra; Benites, Nilson R

    2015-12-01

    Reintroduction is a growing field in the conservation of endangered species. The vinaceous Amazon parrot (Amazona vinacea) is extinct in several areas, and a project to release confiscated individuals to their former range is currently underway. The objective of this study was to evaluate and improve the selection and treatment of individual release candidates by detecting possible pathogen carriers using samples taken before and during release. As part of prerelease health protocols, samples were obtained from 29 parrots on three different occasions while in captivity and once after their release. Samples were screened for paramyxovirus type 1, avian influenza, poxvirus, coronavirus, psittacine herpesvirus 1, Chlamydia psittaci , enteropathogenic Escherichia coli (EPEC), Salmonella spp., and endoparasites. The majority of samples returned negative results, with the exception of two individuals that tested positive for C. psittaci in the first sampling and for Ascaridia spp. in the second pooled sampling. Treatments for C. psittaci and endoparasites were administered prior to release, and negative results were obtained in subsequent exams. The number of positive results for E. coli (non-EPEC) decreased during the rehabilitation period. Adequate quarantine procedures and health examinations greatly minimize disease risks. The protocols employed in this study resulted in acceptable health status in accordance with current environmental legislation in Brazil. Additionally, protocols allowed informed decisions to release candidates, minimized risks, and favored the selection of healthy individuals, thereby contributing to the recovery of this species. It is important to determine appropriate minimum health-screening protocols when advanced diagnostics may not be available or high costs make the tests prohibitive in countries where confiscations occur. We hypothesize that a minimum panel of tests of pooled samples can serve as an alternative approach that minimizes

  18. Safe sanitation: Findings from the impact evaluation baseline survey in Orissa, India. Financial Inclusion improves sanitation and health - FINSIH Project

    OpenAIRE

    Augsburg, Britta

    2011-01-01

    FINISH - Financial Inclusion Improves Sanitation and Health - is a joint undertaking of a wide range of actors that came together to address the challenges of micro finance, insurance and sanitation and health. The overall goal of the project itself is to built 1 million safe toilets (possibly sanitation systems), financed through microfinance loans.

  19. Revisiting the metabolism and physiological functions of caprylic acid (C8:0) with special focus on ghrelin octanoylation.

    Science.gov (United States)

    Lemarié, Fanny; Beauchamp, Erwan; Legrand, Philippe; Rioux, Vincent

    2016-01-01

    Caprylic acid (octanoic acid, C8:0) belongs to the class of medium-chain saturated fatty acids (MCFAs). Dairy products and specific oils like coconut oil are natural sources of dietary C8:0 but higher intakes of this fatty acid can be provided with MCT (Medium-Chain Triglycerides) oil that consists in 75% of C8:0. MCFAs have physical and metabolic properties that are distinct from those of long-chain saturated fatty acids (LCFAs ≥ 12 carbons). Beneficial physiological effects of dietary C8:0 have been studied for a long time and MCT oil has been used as a special energy source for patients suffering from pancreatic insufficiency, impaired lymphatic chylomicron transport and fat malabsorption. More recently, caprylic acid was also shown to acylate ghrelin, the only known peptide hormone with an orexigenic effect. Through its covalent binding to the ghrelin peptide, caprylic acid exhibits an emerging and specific role in modulating physiological functions themselves regulated by octanoylated ghrelin. Dietary caprylic acid is therefore now suspected to provide the ghrelin O-acyltransferase (GOAT) enzyme with octanoyl-CoA co-substrates necessary for the acyl modification of ghrelin. This review tries to highlight the discrepancy between the formerly described beneficial effects of dietary MCFAs on body weight loss and the C8:0 newly reported effect on appetite stimulation via ghrelin octanoylation. The subsequent aim of this review is to demonstrate the relevance of carrying out further studies to better understand the physiological functions of this particular fatty acid.

  20. Médicarte software developed for the Quebec microprocessor health card project.

    Science.gov (United States)

    Lavoie, G; Tremblay, L; Durant, P; Papillon, M J; Bérubé, J; Fortin, J P

    1995-01-01

    The Quebec Patient Smart Card Project is a Provincial Government initiative under the responsibility of the Rgie de l'assurance-maladie du Québec (Quebec Health Insurance Board). Development, implementation, and assessment duties were assigned to a team from Université Laval, which in turn joined a group from the Direction de la santé publique du Bas-St-Laurent in Rimouski, where the experiment is taking place. The pilot project seeks to evaluate the use and acceptance of a microprocessor card as a way to improve the exchange of clinical information between card users and various health professionals. The card can be best described as a résumé containing information pertinent to an individual's health history. It is not a complete medical file; rather, it is a summary to be used as a starting point for a discussion between health professionals and patients. The target population is composed of persons 60 years and over, pregnant women, infants under 18 months, and the residents of a small town located in the target area, St-Fabien, regardless of age. The health professionals involved are general practitioners, specialists, pharmacists, nurses, and ambulance personnel. Participation in the project is on a voluntary basis. Each health care provider participating in the project has a personal identification number (PIN) and must use both an access card and a user card to access information. This prevents unauthorized access to a patient's card and allows the staff to sign and date information entered onto the patient card. To test the microprocessor card, we developed software based on a problem-oriented approach integrating diagnosis, investigations, treatments, and referrals. This software is not an expert system that constrains the clinician to a particular decisional algorithm. Instead, the software supports the physician in decision making. The software was developed with a graphical interface (Windows 3.1) to maximize its user friendliness. A version of the

  1. Médicarte software developed for the Quebec microprocessor health card project.

    Science.gov (United States)

    Lavoie, G; Tremblay, L; Durant, P; Papillon, M J; Bérubé, J; Fortin, J P

    1995-01-01

    The Quebec Patient Smart Card Project is a Provincial Government initiative under the responsibility of the Rgie de l'assurance-maladie du Québec (Quebec Health Insurance Board). Development, implementation, and assessment duties were assigned to a team from Université Laval, which in turn joined a group from the Direction de la santé publique du Bas-St-Laurent in Rimouski, where the experiment is taking place. The pilot project seeks to evaluate the use and acceptance of a microprocessor card as a way to improve the exchange of clinical information between card users and various health professionals. The card can be best described as a résumé containing information pertinent to an individual's health history. It is not a complete medical file; rather, it is a summary to be used as a starting point for a discussion between health professionals and patients. The target population is composed of persons 60 years and over, pregnant women, infants under 18 months, and the residents of a small town located in the target area, St-Fabien, regardless of age. The health professionals involved are general practitioners, specialists, pharmacists, nurses, and ambulance personnel. Participation in the project is on a voluntary basis. Each health care provider participating in the project has a personal identification number (PIN) and must use both an access card and a user card to access information. This prevents unauthorized access to a patient's card and allows the staff to sign and date information entered onto the patient card. To test the microprocessor card, we developed software based on a problem-oriented approach integrating diagnosis, investigations, treatments, and referrals. This software is not an expert system that constrains the clinician to a particular decisional algorithm. Instead, the software supports the physician in decision making. The software was developed with a graphical interface (Windows 3.1) to maximize its user friendliness. A version of the

  2. Implementation of mass media community health education: the Forsyth County Cervical Cancer Prevention Project.

    Science.gov (United States)

    Dignan, M; Bahnson, J; Sharp, P; Beal, P; Smith, M; Michielutte, R

    1991-09-01

    The Forsyth County Cervical Cancer Prevention Project (FCP) is a community-based health education project funded by the National Cancer Institute. The target population includes around 25 000 black women age 18 and older who reside in Forsyth County, North Carolina. The overall goal of the program is to prevent mortality from cervical cancer by promoting Pap smears and return for follow-up care when needed. Based on the principles of social marketing, a plan to reach the target population with mass media educational messages through electronic and print channels was developed. Guided by marketing objectives, the target population was divided into relatively discrete segments. The segments included church attenders, patients in waiting rooms of public and selected health providers, female students at local colleges, shoppers, viewers of radio and television, newspaper readers, and business owners and managers. Introduction of the program was based on strategies developed for reaching the target population in each segment with television, radio and print mass media messages. Qualitative assessment of the mass media developed by the program indicated that all forms of communication helped to increase awareness of the program. PMID:10148691

  3. Weird Project: E-Health Service Improvement Using WiMAX

    Science.gov (United States)

    Cimmino, Antonio; Casali, Fulvio; Mambretti, Cinzia

    Today the major obstacle to massive deployment of telemedicine applications are the security issues related to the exchange of real time information between different elements that are not at fixed locations. WiMAX, the new standard for wireless communications, is one of the most promising technologies for broadband access in a fixed and mobile environment and it is expected to overcome the above mentioned obstacle. The FP6-WEIRD [1] (WiMax Extension to Isolated Remote Data networks) project has: analysed how this technology can guarantee secure real time data transmission between mobile elements, built some successful demonstrations and paved the way to future commercial applications. This paper in particular describes: main promising e-health applications that WiMax would enable; the technological highlights and the main challenges that WiMax has to face in e-health applications such as accounting, privacy, security, data integrity; the way in which the WEIRD project 0 has studied the wireless access to medical communities and equipment in remote or impervious areas. 0 0; some envisaged implementations.

  4. Health system and societal barriers for gestational diabetes mellitus (GDM services - lessons from World Diabetes Foundation supported GDM projects

    Directory of Open Access Journals (Sweden)

    Nielsen Karoline Kragelund

    2012-12-01

    Full Text Available Abstract Background Maternal mortality and morbidity remains high in many low- and middle-income countries (LMIC. Gestational Diabetes Mellitus (GDM represents an underestimated and unrecognised impediment to optimal maternal health in LMIC; left untreated – it also has severe consequences for the offspring. A better understanding of the barriers hindering detection and treatment of GDM is needed. Based on experiences from World Diabetes Foundation (WDF supported GDM projects this paper seeks to investigate societal and health system barriers to such efforts. Methods Questionnaires were filled out by 10 WDF supported GDM project partners implementing projects in eight different LMIC. In addition, interviews were conducted with the project partners. The interviews were analysed using content analysis. Results Barriers to improving maternal health related to GDM nominated by project implementers included lack of trained health care providers - especially female doctors; high staff turnover; lack of standard protocols, consumables and equipment; financing of health services and treatment; lack of or poor referral systems, feedback mechanisms and follow-up systems; distance to health facility; perceptions of female body size and weight gain/loss in relation to pregnancy; practices related to pregnant women’s diet; societal negligence of women’s health; lack of decision-making power among women regarding their own health; stigmatisation; role of women in society and expectations that the pregnant woman move to her maternal home for delivery. Conclusions A number of barriers within the health system and society exist. Programmes need to consider and address these barriers in order to improve GDM care and thereby maternal health in LMIC.

  5. Projection models for health effects assessment in populations exposed to radioactive and nonradioactive pollutants. Volume IV. SPAHR user's guide

    International Nuclear Information System (INIS)

    The Simulation Package for the Analysis of Health Risk (SPAHR) is a computer software package based upon a demographic model for health risk projections. The model extends several health risk projection models by making realistic assumptions about the population at risk, and thus represents a distinct improvement over previous models. Complete documentation for use of SPAHR is contained in this five-volume publication. The demographic model in SPAHR estimates population response to environmental toxic exposures. Latency of response, changing dose level over time, competing risks from other causes of death, and population structure can be incorporated into SPAHR to project health risks. Risks are measured by morbid years, number of deaths, and loss of life expectancy. Comparisons of estimates of excess deaths demonstrate that previous health risk projection models may have underestimated excess deaths by a factor of from 2 to 10, depending on the pollutant and the exposure scenario. The software supporting the use of the demographic model is designed to be user oriented. Complex risk projections are made by responding to a series of prompts generated by the package. The flexibility and ease of use of SPAHR make it an important contribution to existing models and software packages. This volume gives the more advanced user of the SPAHR computer package the information required to create tailor-made programs for addressing specific issues not covered by the three interactive packages. It assumes that the user is familiar with the concepts and terms relating to demography and health risk assessment

  6. Health problems among migrant construction workers: A unique public-private partnership project

    Directory of Open Access Journals (Sweden)

    Balkrishna B Adsul

    2011-01-01

    Full Text Available Background: Construction sector is a booming industry and involves many hazardous activities. Migrant labor in the industry is susceptible to various health and occupational hazards. In a unique public-private partnership project, a medical team from a public sector teaching hospital in Mumbai provided comprehensive on-site health care services to the construction workers of a private construction company. Objective: To study socio-demographic profile and morbidity pattern of construction workers. Setting and Design: A cross-sectional study at construction site Vidyavihar (West, Mumbai, was carried out over the period of May to November 2010. Materials and Methods: A medical team provided comprehensive on-site health care services, and a Health Card was devised to maintain the record of socio-demographic, occupational details, and complete physical examination findings of the workers who participated in the study. Statistical Analysis Used: Statistical analysis was done using SPSS 15.0. Results: Of the 1337 workers (all males examined, 1289 (96.4% belonged to 15-45 years age group. The mean age of the workers was 26.25 ± 8.49 years. A third of the migrants belonged to West Bengal. The average number of health problems in the workers was 1.41. Regular consumers of tobacco and alcohol were 50.48 and 14.65%, respectively. Nearly one-fifth of the workers had febrile illness, of which 20.71% had suspected malaria; 12.6% had respiratory infections, while 3.4% were found to have hypertension. There was a statistically significant association (P < 0.05 between type of occupation and morbidity status.

  7. Health problems among migrant construction workers: A unique public–private partnership project

    Science.gov (United States)

    Adsul, Balkrishna B.; Laad, Payal S.; Howal, Prashant V.; Chaturvedi, Ramesh M.

    2011-01-01

    Background: Construction sector is a booming industry and involves many hazardous activities. Migrant labor in the industry is susceptible to various health and occupational hazards. In a unique public–private partnership project, a medical team from a public sector teaching hospital in Mumbai provided comprehensive on-site health care services to the construction workers of a private construction company. Objective: To study socio-demographic profile and morbidity pattern of construction workers. Setting and Design: A cross-sectional study at construction site Vidyavihar (West), Mumbai, was carried out over the period of May to November 2010. Materials and Methods: A medical team provided comprehensive on-site health care services, and a Health Card was devised to maintain the record of socio-demographic, occupational details, and complete physical examination findings of the workers who participated in the study. Statistical Analysis Used: Statistical analysis was done using SPSS 15.0. Results: Of the 1337 workers (all males) examined, 1289 (96.4%) belonged to 15–45 years age group. The mean age of the workers was 26.25 ± 8.49 years. A third of the migrants belonged to West Bengal. The average number of health problems in the workers was 1.41. Regular consumers of tobacco and alcohol were 50.48 and 14.65%, respectively. Nearly one-fifth of the workers had febrile illness, of which 20.71% had suspected malaria; 12.6% had respiratory infections, while 3.4% were found to have hypertension. There was a statistically significant association (P < 0.05) between type of occupation and morbidity status. PMID:21808498

  8. Estimating NOA Health Risks from Selected Construction Activities at the Calaveras Dam Replacement Project (CDRP)

    Science.gov (United States)

    Hernandez, D. W.

    2012-12-01

    The CDRP is a major construction project involving up to 400 workers using heavy earth moving equipment, blasting, drilling, rock crushing, and other techniques designed to move 7 million yards of earth. Much of this material is composed of serpentinite, blueschist, and other rocks that contain chrysotile, crocidolite, actinolite, tremolite, and Libby-class amphiboles. To date, over 1,000 personal, work area, and emission inventory related samples have been collected and analyzed by NIOSH 7400, NIOSH 7402, and CARB-AHERA methodology. Data indicate that various CDRP construction activities have the potential to generate significant mineral fibers and structures that could represent elevated on site and off site health risks. This presentation will review the Contractors air monitoring program for this major project, followed by a discussion of predictive methods to evaluate potential onsite and offsite risks. Ultimately, the data are used for planning control strategies designed to achieve a Project Action Level of 0.01 f/cc (one tenth the Cal/OSHA PEL) and risk-based offsite target levels.

  9. Occupational Safety and Health Program at the West Valley Demonstration Project

    Energy Technology Data Exchange (ETDEWEB)

    L. M. Calderon

    1999-04-30

    The West Valley Nuclear Services Co. LLC (WVNS) is committed to provide a safe, clean, working environment for employees, and to implement U.S. Department of Energy (DOE) requirements affecting worker safety. The West Valley Demonstration Project (WVDP) Occupational Safety and Health Program is designed to protect the safety, health, and well-being of WVDP employees by identifying, evaluating, and controlling biological, chemical, and physical hazards in the work place. Hazards are controlled within the requirements set forth in the reference section at the end of this report. It is the intent of the WVDP Occupational Safety and Health Program to assure that each employee is provided with a safe and healthy work environment. This report shows the logical path toward ensuring employee safety in planning work at the WVDP. In general, planning work to be performed safely includes: combining requirements from specific programs such as occupational safety, industrial hygiene, radiological control, nuclear safety, fire safety, environmental protection, etc.; including WVDP employees in the safety decision-making processes; pre-planning using safety support re-sources; and integrating the safety processes into the work instructions. Safety management principles help to define the path forward for the WVDP Occupational Safety and Health Program. Roles, responsibilities, and authority of personnel stem from these ideals. WVNS and its subcontractors are guided by the following fundamental safety management principles: ''Protection of the environment, workers, and the public is the highest priority. The safety and well-being of our employees, the public, and the environment must never be compromised in the aggressive pursuit of results and accomplishment of work product. A graded approach to environment, safety, and health in design, construction, operation, maintenance, and deactivation is incorporated to ensure the protection of the workers, the public, and the

  10. Occupational Safety and Health Program at the West Valley Demonstration Project

    International Nuclear Information System (INIS)

    The West Valley Nuclear Services Co. LLC (WVNS) is committed to provide a safe, clean, working environment for employees, and to implement U.S. Department of Energy (DOE) requirements affecting worker safety. The West Valley Demonstration Project (WVDP) Occupational Safety and Health Program is designed to protect the safety, health, and well-being of WVDP employees by identifying, evaluating, and controlling biological, chemical, and physical hazards in the work place. Hazards are controlled within the requirements set forth in the reference section at the end of this report. It is the intent of the WVDP Occupational Safety and Health Program to assure that each employee is provided with a safe and healthy work environment. This report shows the logical path toward ensuring employee safety in planning work at the WVDP. In general, planning work to be performed safely includes: combining requirements from specific programs such as occupational safety, industrial hygiene, radiological control, nuclear safety, fire safety, environmental protection, etc.; including WVDP employees in the safety decision-making processes; pre-planning using safety support re-sources; and integrating the safety processes into the work instructions. Safety management principles help to define the path forward for the WVDP Occupational Safety and Health Program. Roles, responsibilities, and authority of personnel stem from these ideals. WVNS and its subcontractors are guided by the following fundamental safety management principles: ''Protection of the environment, workers, and the public is the highest priority. The safety and well-being of our employees, the public, and the environment must never be compromised in the aggressive pursuit of results and accomplishment of work product. A graded approach to environment, safety, and health in design, construction, operation, maintenance, and deactivation is incorporated to ensure the protection of the workers, the public, and the environment

  11. Ethics issues experienced in HBM within Portuguese health surveillance and research projects

    Directory of Open Access Journals (Sweden)

    Miguel J Pereira

    2008-01-01

    Full Text Available Abstract Background In keeping with the fundamental practice of transparency in the discussion and resolution of ethics conflicts raised by research, a summary of ethics issues raised during Portuguese biomonitoring in health surveillance and research is presented and, where applicable, their resolution is described. Methods Projects underway aim to promote the surveillance of public health related to the presence of solid waste incinerators or to study associations between human exposure to environmental factors and adverse health effects. The methodological approach involves biomonitoring of heavy metals, dioxins and/or other persistent organic pollutants in tissues including blood, human milk and both scalp and pubic hair in groups such as the general population, children, pregnant women or women attempting pregnancy. As such, the projects entail the recruitment of individuals representing different demographic and health conditions, the collection of body tissues and personal data, and the processing of the data and results. Results The issue of autonomy is raised during the recruitment of participants and during the collection of samples and data. This right is protected by the requirement for prior written, informed consent from the participant or, in the case of children, from their guardian. Recruitment has been successful, among eligible participants, in spite of incentives rarely being offered. The exception has been in obtaining guardians' consent for children's participation, particularly for blood sampling. In an attempt to mitigate the harm-benefit ratio, current research efforts include alternative less invasive biomarkers. Surveys are currently being conducted under contract as independent biomonitoring actions and as such, must be explicitly disclosed as a potential conflict of interests. Communication of results to participants is in general only practised when a health issue is present and corrective action possible

  12. Assessment of Cost Impact in Health and Safety on Construction Projects

    Directory of Open Access Journals (Sweden)

    Bima Abubakar Muhammad

    2015-03-01

    Full Text Available The study assesses the cost impact of Health and Safety management within the construction industry. The purpose of the study is to help identify the impact of cost directly to projects. Toward this end, a field survey was conducted with a sample of fifty contractors selected in a given geographical region with high density of construction work. Data were collected using structured questionnaires and analyzed using a tabular presentation identifying percentages of given responses. The results reveal that contractors are aware that health and safety compliance is correlated with the scope of their operations. The study results also reveal that the accident and injury rates in the Nigerian construction industry are high. Thus, the results reveal the challenges facing Nigerian contractors and companies in terms of high cost incurred as a result of injuries and hazards on site.. The findings indicate the need for effective health and safety management and regulation and control of activities in the Nigerian construction industry more definitively.

  13. An Exploitation of Satellite-based Observation for Health Information: The UFOS Project

    Energy Technology Data Exchange (ETDEWEB)

    Mangin, A.; Morel, M.; Fanton d' Andon, O

    2000-07-01

    Short, medium and long-term trends of UV intensity levels are of crucial importance for either assessing effective biological impacts on human population, or implementing adequate preventive behaviours. Better information on a large spatial scale and increased public awareness of the short-term variations in UV values will help to support health agencies' goals of educating the public on UV risks. The Ultraviolet Forecast Operational Service Project (UFAS), financed in part by the European Commission/DG Information Society (TEN-TELECOM programme), aims to exploit satellite-based observations and to supply a set of UV products directly useful to health care. The short-term objective is to demonstrate the technical and economical feasibility and benefits that could be brought by such a system. UFOS is carried out by ACRI, with the support of an Advisory Group chaired by WHO and involving representation from the sectors of Health (WHO, INTERSUN collaborating centres, ZAMBON), Environment (WMO, IASB), and Telecommunications (EURECOM, IMET). (author)

  14. C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones: novel muscarinic receptor antagonists.

    Science.gov (United States)

    Kim, Myoung Goo; Bodor, Erik T; Wang, Chen; Harden, T Kendall; Kohn, Harold

    2003-05-22

    Expedient syntheses of C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones are reported to begin with 2,5-disubstituted pyridines. Catalytic reduction of the pyridine to the piperidine followed by treatment with ethyl acrylate and Dieckmann cyclization gave diastereomeric mixtures of C(8) substituted 3-ethoxycarbonyl-4-hydroxy-1-azabicyclo[3.3.1]non-3-enes, which were separable by chromatography. We found that the catalytic reduction (PtO2, H2) procedure provided the cis-substituted piperidine but that pyridine reduction was accompanied by competitive cleavage of the C(2) pyridyl substituent. Accordingly, an alternative route was devised that afforded a diastereomeric mixture of the cis- and trans-2,5-disubstituted piperidine. Treatment of the substituted pyridine with m-CPBA gave the pyridine N-oxide, which was reduced to the piperidine by sequential reduction with ammonium formate in the presence of Pd-C followed by NaBH3CN. Addition of ethyl acrylate completed the synthesis of the substituted piperidine. The overall four-step reaction gave higher yields (57%) than the two-step procedure (13%) with little cleavage of the C(2) pyridyl substituent. Acid decarboxylation of the bicyclo[3.3.1]non-3-enes provided the C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones. Structural studies revealed diagnostic 13C NMR signals that permit assignment of the orientation of the C(8) substituent. Pharmacological investigations documented that 3-ethoxycarbonyl-4-hydroxy-1-azabicyclo[3.3.1]non-3-enes efficiently bind to the human M1-M5 muscarinic receptors and function as antagonists. We observed that exo-8-benzyloxymethyl-3-ethoxycarbonyl-4-hydroxy-1-azabicyclo[3.3.1]non-3-ene (3) displayed the highest affinity, exhibiting Ki values at all five muscarinic receptors that were approximately 10-50 times lower than carbachol and approximately 30-230 times lower than arecoline. Receptor selectivity was observed for 3. Compound 3 contained

  15. Absence of the human CYP2C8*3 allele in Ugandan children exposed to Plasmodium falciparum malaria.

    Science.gov (United States)

    Paganotti, Giacomo Maria; Cosentino, Valentina; Russo, Gianluca; Tabacchi, Francesca; Gramolelli, Silvia; Coluzzi, Mario; Romano, Rita

    2014-10-01

    Study of host pharmacogenetics can improve our knowledge of mechanisms of drug resistance selection and spread. This issue has recently been addressed with respect to chloroquine and amodiaquine in malaria endemic areas of West and East Africa. Here we report, from surveys performed in two different areas of Uganda, that the human CYP2C8*3 allele, which had been reported to be strongly associated with parasite drug resistance in Zanzibar, is absent, being a marker of genetic admixture of the Zanzibari population with a Caucasoid component. Moreover, a retrospective analysis of CYP2C8*2 and the Plasmodium falciparum drug resistant pfmdr1 86Y allele does not show any association, which may be related to the high level of drug resistance.

  16. Projection models for health-effects assessment in populations exposed to radioactive and nonradioactive pollutants. Volume V. SPAHR programmer's guide

    International Nuclear Information System (INIS)

    The Simulation Package for the Analysis of Health Risk (SPAHR) is a computer software package based upon a demographic model for health risk projections. The model extends several health risk projection models by making realistic assumptions about the population at risk, and thus represents a distinct improvement over previous models. Complete documentation for use of SPAHR is contained in this five-volume publication. The demographic model in SPAHR estimates population response to environmental toxic exposures. Latency of response, changing dose level over time, competing risks from other causes of death, and population structure can be incorporated into SPAHR to project health risks. Risks are measured by morbid years, numbers of deaths, and loss of life expectancy. Comparisons of estimates of excess deaths demonstrate that previous health risk projection models may have underestimated excess deaths by a factor of from 2 to 10, depending on the pollutant and the exposure scenario. The software supporting the use of the demographic model is designed to be user oriented. Complex risk projections are made by responding to a series of prompts generated by the package. The flexibility and ease of use of SPAHR make it an important contribution to existing models and software packages. This volume contains a programmer's guide to SPAHR

  17. A Remarkable Oxidative Cascade That Replaces the Riboflavin C8 Methyl with an Amino Group during Roseoflavin Biosynthesis.

    Science.gov (United States)

    Jhulki, Isita; Chanani, Prem K; Abdelwahed, Sameh H; Begley, Tadhg P

    2016-07-13

    Roseoflavin is a naturally occurring riboflavin analogue with antibiotic properties. It is biosynthesized from riboflavin in a reaction involving replacement of the C8 methyl with a dimethylamino group. Herein we report the identification of a flavin-dependent enzyme that converts flavin mononucleotide (FMN) and glutamate to 8-amino-FMN via the intermediacy of 8-formyl-FMN. A mechanistic proposal for this remarkable transformation is proposed. PMID:27331868

  18. Projected global health impacts from severe nuclear accidents: Conversion of projected doses to risks on a global scale: Experience from Chernobyl releases

    International Nuclear Information System (INIS)

    Estimates of projected collective dose and average individual dose commitments from Chernobyl releases were made for various regions. Consideration was given to the possible effectiveness of protective actions taken by various countries to reduce projected doses to their populations. Although some preliminary data indicate possible mean reductions of about 25% in total collective doses over the first year, and of about 55% in collective dose to the thyroid, no corrections were made to these dose estimates because of the variable nature of the data. A new combined set of dose-effect models recently published by the United States Nuclear Regulatory Commission was then applied to estimate the ranges of possible future additional health effects due to the Chernobyl accident. In this method possible health effects are estimated on an individual site basis and the results are then summed. Both absolute and relative risk projection models are used. By use of these methods, ''best'' estimates of possible additional health effects were projected for the Northern Hemisphere as follows: 1) over the next 50 years, up to 28 thousand radiation-induced fatal cancers, compared to an expected 600 million cancer deaths from natural or spontaneous causes; 2) over the next year, up to 700 additional cases of severe mental retardation, compared to a normal expectation of 340 thousand cases; and 3) in the first generation, up to 1.9 thousand radiation-induced genetic disorders, compared to 180 million naturally-occurring cases. The possibility of zero health effects at very low doses and dose rates cannot be excluded. Owing to the very large numbers of naturally-occurring health effects, it is unlikely that any additional health effects will be demonstrable except, perhaps, for the more highly exposed population in the immediate vicinity of Chernobyl. 13 refs, 4 figs, 6 tabs

  19. [The "healthy community" project--morbidity, risk factors, health behavior and psychiatric symptoms in Steiermark].

    Science.gov (United States)

    Klebel, H; Stronegger, W J

    1996-01-01

    27,344 persons in Styria participated in a study of the "Steirische Gesellschaft für Gesundheitsschutz" in Graz, within the framework of the project "Healthy communities" and were asked about diseases and health attitudes. All analyses were made separately for men and women and were adjusted for age and education. The goal of this study was a regional comparison of chronic diseases, risk factors, health consciousness and psychiatric complaints. Thus it should be possible to define the problematic regions with regard to health, in order to take the necessary political action to improve the situation. Men and women show a relative lack of health consciousness in the Weinbauregion and East Styria. Psychiatric complaints of women are more frequent in the Weinbauregion than the other areas. It appears that the healthier people live in the regions Mur/Mürztal and the Ennstal. Women have less risk factors than men, but have more psychiatric complaints. Men live less healthy lives in relation to their nutrition, risk avoidance and dental hygiene, except with respect to sports. Of the interviewed people from the surroundings of Graz 63% suffer from chronic disease, whilst in the Mur/Mürz- and Ennstal the respective figure is 56%. In the wine growing regions 54% of men drink alcohol daily, whereas in the Mur/Mürz- and Ennstal 42% of men drink alcohol daily. In the wine-growing regions 35% of the women and 50% of the men are overweight; in the Ennstal only 28% of the women are overweight but 45% of the men. Regular sports activities are undertaken by 35% of the women and 38% of the men in the Ennstal, as compared with 22% of the women and 27% of the men in East Styria. Insomnia was recorded in 29% of the women in East Styria, but in only 22% of the women in the Mur/Mürztal.

  20. Needs analysis and project schedule for the Los Alamos National Laboratory (LANL) Health Physics Analysis Laboratory (HPAL) upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Rhea, T.A.; Rucker, T.L. [Science Applications International Corp., Oak Ridge, TN (United States); Stafford, M.W. [NUS Corp., Aiken, SC (US)

    1990-09-28

    This report is a needs assessment and project schedule for the Health Physics Analysis Laboratory (HPAL) upgrade project at Los Alamos National Laboratory (LANL). After reviewing current and projected HPAL operations, two custom-developed laboratory information management systems (LIMS) for similar facilities were reviewed; four commercially available LIMS products were also evaluated. This project is motivated by new regulations for radiation protection and training and by increased emphasis on quality assurance (QA). HPAL data are used to: protect the health of radiation workers; document contamination levels for transportation of radioactive materials and for release of materials to the public for uncontrolled use; and verify compliance with environmental emission regulations. Phase 1 of the HPAL upgrade project concentrates on four types of counting instruments which support in excess of 90% of the sample workload at the existing central laboratories. Phase 2 is a refinement phase and also integrates summary-level databases on the central Health, Safety, and Environment (HSE) VAX. Phase 3 incorporates additional instrument types and integrates satellite laboratories into the HPAL LIMS. Phase 1 will be a multi-year, multimillion dollar project. The temptation to approach the upgrade of the HPAL program in a piece meal fashion should be avoided. This is a major project, with clearly-defined goals and priorities, and should be approached as such. Major programmatic and operational impacts will be felt throughout HSE as a result of this upgrade, so effective coordination with key customer contacts will be critical.

  1. Air quality and students' health in Shanghai (China): an educational and scientific project

    Science.gov (United States)

    Bigot-Cormier, Florence; Nicolaï, Marie-Pierre; Martinez, Claire-Marie; Bethmont, Valérie; Guinot, Benjamin

    2014-05-01

    The quality of our environment and especially air quality is a hot topic in any urban environment. Hourly air quality data tend to be easily available to the populations either in the news or on mobile phones. Studies underlining the relationship between environment and health exist in developed countries, but the results cannot be used in such different environmental and sociological contexts as the ones we have in China. In collaboration with the CNRS, students from the Lycée Français de Shanghai (LFS- 5th and 2nd grade) undertake a study in order to obtain an empiric relationship between the atmospheric pollutants they are exposed to in and out the classrooms, and their own health. This study is a part of a scientific and educational project including Beijing, and possibly other foreign schools in Asia later on. The atmospheric pollution in China is essentially caused by particles from different sizes mainly coming from coal combustion. First, in order to quantify the pollution at Shanghai, the students are recording information regarding fine particles as PM2.5 and PM1.0, NO2, SO2, and O3 using active and passive sensors indoors and outdoors, within the school campus. CO2, temperature and relative humidity are used to qualify the confinement rate indoors. In parallel, approximately 100 students (chosen regarding their age, health records, residence time in China…) and some teachers are going to complete a monthly survey regarding their health. Moreover, they will perform some specific measurements to obtain their breathing performances by spirometry, and an indication of the inflammation of their lower airways by exhaled NO measurements. The protocol of these experimentations and the first results will be presented in the poster. At the end of the project, these results will allow us to get a better knowledge about the air pollution we are exposed to, within the school campus, which will help us to adopt an optimized risk management protocol when pollution

  2. Molecular cloning, characterization and expression analysis of complement component C8 beta in the orange-spotted grouper (Epinephelus coioides) after the Vibrio alginolyticus challenge.

    Science.gov (United States)

    Luo, Shengwei; Xie, Fuxing; Liu, Yuan; Wang, Wei-Na

    2015-03-10

    Complement component C8 beta was a key molecule in the complement system, mediating the MAC formation and the bacterial lysis. In this study, the full-length C8 beta (EcC8 beta) was obtained, containing a 5'UTR of 25 bp, an ORF of 1764 bp and a 3'UTR of 198 bp. The EcC8 beta gene encoded a protein of 587 amino acids with an estimated molecular mass of 65.87 kDa and a predicted isoelectric point (pI) of 6.35. The deduced amino acid sequence showed that EcC8 beta consisted of the conserved residues and the domains known to be critical for C8 beta function. The quantitative real-time PCR analysis revealed that EcC8 beta transcript was expressed in all the examined tissues, while the strong expression was observed in the liver. In addition, complement C3 was the central molecule in the complement system, converging the upstream complement signals and mediating the MAC assembly pathway, while C8 beta was indispensable for active MAC formation. Following the Vibrio challenge, the increased expression of EcC3 transcript and EcC8 beta transcript was observed in the liver and kidney. These results indicated that EcC8 beta may be an important immune-related gene, playing an important role in the immune defense against the bacterial infection via the complement pathway.

  3. [Health impact assessment of policies for municipal solid waste management: findings of the SESPIR Project].

    Science.gov (United States)

    Ranzi, Andrea; Ancona, Carla; Angelini, Paola; Badaloni, Chiara; Cernigliaro, Achille; Chiusolo, Monica; Parmagnani, Federica; Pizzuti, Renato; Scondotto, Salvatore; Cadum, Ennio; Forastiere, Francesco; Lauriola, Paolo

    2014-01-01

    The SESPIR Project (Epidemiological Surveillance of Health Status of Resident Population Around the Waste Treatment Plants) assessed the impact on health of residents nearby incinerators, landfills and mechanical biological treatment plants in five Italian regions (Emilia-Romagna, Piedmont, Lazio, Campania, and Sicily). The assessment procedure took into account the available knowledge on health effects of waste disposal facilities. Analyses were related to three different scenarios: a Baseline scenario, referred to plants active in 2008-2009; the regional future scenario, with plants expected in the waste regional plans; a virtuous scenario (Green 2020), based on a policy management of municipal solid waste (MSW) through the reduction of production and an intense recovery policy. Facing with a total population of around 24 million for the 5 regions, the residents nearby the plants were more than 380,000 people at Baseline. Such a population is reduced to approximately 330.000 inhabitants and 170.000 inhabitants in the regional and Green 2020 scenarios, respectively. The health impact was assessed for the period 2008-2040. At Baseline, 1-2 cases per year of cancer attributable to MSW plants were estimated, as well as 26 cases per year of adverse pregnancy outcomes (including low birth weight and birth defects), 102 persons with respiratory symptoms, and about a thousand affected from annoyance caused by odours. These annual estimates are translated into 2,725 years of life with disability (DALYs) estimated for the entire period. The DALYs are reduced by approximately 20% and 80% in the two future scenarios. Even in these cases, health impact is given by the greater effects on pregnancy and the annoyance associated with the odours of plants. In spite of the limitations due to the inevitable assumptions required by the present exercise, the proposed methodology is suitable for a first approach to assess different policies that can be adopted in regional planning in

  4. Environment, safety and health progress assessment of the Fernald Environmental Management Project (FEMP)

    International Nuclear Information System (INIS)

    This report documents the results of the Environment, Safety, and Health (ES ampersand H) Progress Assessment of the Fernald Environmental Management Project (FEMP), Fernald, Ohio, conducted from October 15 through October 25, 1991. The Secretary of Energy directed that small, focused, ES ampersand H Progress Assessments be performed as part of the continuing effort to institutionalize line management accountability and the self-assessment process in the areas of ES ampersand H. The FEMP assessment is the pilot assessment for this new program. The objectives for the FEMP ES ampersand H Progress Assessment were to assess: (1) how the FEMP has progressed since the 1989 Tiger Assessment; (2) how effectively the FEMP has corrected specific deficiencies and associated root causes identified by that team; and (3) whether the current organization, resources, and systems are sufficient to proactively manage ES ampersand H issues

  5. Quality of Life Programme--food, nutrition, and health--projects promotion.

    Science.gov (United States)

    Boenke, A

    2001-03-01

    The EC Quality of Life Programme (QoL), Key Action 1--Food, Nutrition & Health aims at providing a healthy, safe, and high-quality food supply leading to reinforced consumer's confidence in the safety of the European food. Key Action 1 is currently supporting several European projects investigating analytical methods for food control including sensors, risk analysis, and food safety standardisation. Their objectives range from the development and validation of prevention strategies for mycotoxin formation via the development of a communication platform for Genetically Modified Organisms (GMO), validation and standardisation of diagnostic Polymerase Chain Reaction (PCR) for food-borne pathogens, up to the evaluation of the potential cancer-preventing activity of pro- and pre-biotic ("SYNBIOTIC") combinations in human volunteers. This paper also informs on future research needs in food safety. PMID:11370294

  6. The Human Genome Project in the United States: a perspective on the commercial, ethical, legislative and health care issues.

    Science.gov (United States)

    Mackler, Bruce F; Barach, Micha

    1991-01-01

    The Human Genome Project represents a government supported effort to map and sequence the human genome. Governmental support for the Project should include increased emphasis on grants and contracts to industry. This is particularly true for small highly innovative biotechnology companies that can rapidly integrate and use technology as a base for product development. Private industry must be integrated as a partner into the Project, as it will be in Japan and Europe. There is a consensus in industry that the Genome Project is, at this stage at least, a science research project funded by government and not, at present, a commercial project. It is not seriously expected to have any substantial widespread commercial impact in the near future. The ultimate commercial benefits of the Human Genome Project, in terms of definable health care products, may not be realized until well into the next century. Yet, there are a few companies for which the Genome Project affords immediate commercial opportunities in certain niche areas. The Genome Project can be expected to have a significant impact upon medical knowledge and treatment. Though the Genome Project is just beginning, much of the type of medical knowledge expected to be gained from the Project is already present and even being exploited, albeit on a small scale. The application of genetic understanding to practical applications raises ethical, medical and legal issues central to the Genome Project. Unfortunately, emotion and sensationalism sometimes dominate and prevent a constructive discussion of ethical and social issues pertaining to genetics. To answer public concerns about human gene transfer experiments, the medical and biotechnology communities must constructively discuss the medical realities, the benefits to human health and the adequacy of the current governmental oversights. These presentations must be understandable by the lay public and must address their fears. Failure to assuage public fears and

  7. The NanoCare project: A German initiative on health aspects of synthetic nanoparticles

    International Nuclear Information System (INIS)

    Nanotechnology is increasingly considered to be the future technology. It will enable science and industry to provide new and better product solutions for the society. NanoCare is a German project, funded by the German Federal Ministry of Education and Research (BMBF), which aims to broaden knowledge about synthetic nanomaterials with regard to the potential impacts of nanomaterials on human health. 13 partners from industry, universities and research institutes are contributing their expertise to this partnership. The work plan of the NanoCare project is composed of three different parts: (1) the generation, (2) the management, and (3) the transfer of knowledge. The production of synthetic nanoparticles, the subsequent analysis of primary particles, aggregates and agglomerates, as well as the behaviour in biological media and effects on biological systems are focused in the generation of knowledge. In addition to the production and characterization of new synthetic nanoparticles (metal oxides like zirconium dioxide or zinc oxide), titanium dioxide and Carbon Black will be established as reference materials. This enables the comparison of the results of all partners of our project. Various analytical methods for characterization will be applied, for example: transmission and scanning electron microscopy, inductive coupled plasma mass spectroscopy (ICP-MS), atomic absorption spectroscopy (AAS) and the Brunner-Edward-Teller method (BET). In vitro studies will systematically investigate biological mechanisms of action of nanoparticles and the dependency on their size, shape, zeta potential and other important properties. In vitro data will be complemented by in vivo studies. Another work package deals with the measurement of working place exposure and agglomerate stabilities. Established measurement devices and methods will be developed further in order to determine aerosols and nanoparticles directly at the workplace during ongoing work processes. The stabilities of

  8. The NanoCare project: A German initiative on health aspects of synthetic nanoparticles

    Science.gov (United States)

    Nau, Katja; Krug, Harald F.

    2009-05-01

    Nanotechnology is increasingly considered to be the future technology. It will enable science and industry to provide new and better product solutions for the society. NanoCare is a German project, funded by the German Federal Ministry of Education and Research (BMBF), which aims to broaden knowledge about synthetic nanomaterials with regard to the potential impacts of nanomaterials on human health. 13 partners from industry, universities and research institutes are contributing their expertise to this partnership. The work plan of the NanoCare project is composed of three different parts: (1) the generation, (2) the management, and (3) the transfer of knowledge. The production of synthetic nanoparticles, the subsequent analysis of primary particles, aggregates and agglomerates, as well as the behaviour in biological media and effects on biological systems are focused in the generation of knowledge. In addition to the production and characterization of new synthetic nanoparticles (metal oxides like zirconium dioxide or zinc oxide), titanium dioxide and Carbon Black will be established as reference materials. This enables the comparison of the results of all partners of our project. Various analytical methods for characterization will be applied, for example: transmission and scanning electron microscopy, inductive coupled plasma mass spectroscopy (ICP-MS), atomic absorption spectroscopy (AAS) and the Brunner-Edward-Teller method (BET). In vitro studies will systematically investigate biological mechanisms of action of nanoparticles and the dependency on their size, shape, zeta potential and other important properties. In vitro data will be complemented by in vivo studies. Another work package deals with the measurement of working place exposure and agglomerate stabilities. Established measurement devices and methods will be developed further in order to determine aerosols and nanoparticles directly at the workplace during ongoing work processes. The stabilities of

  9. Projections of heat waves with high impact on human health in Europe

    Science.gov (United States)

    Amengual, A.; Homar, V.; Romero, R.; Brooks, H. E.; Ramis, C.; Gordaliza, M.; Alonso, S.

    2014-08-01

    Climate change will result in more intense, more frequent and longer lasting heat waves. The most hazardous conditions emerge when extreme daytime temperatures combine with warm night-time temperatures, high humidities and light winds for several consecutive days. Here, we assess present and future heat wave impacts on human health in Europe. Present daily physiologically equivalent temperatures (PET) are derived from the ERA-Interim reanalysis. PET allows to specifically focus on heat-related risks on humans. Regarding projections, a suite of high-resolution regional climate models - run under SRES A1B scenario - has been used. A quantile-quantile adjustment is applied to the daily simulated PET to correct biases in individual model climatologies and a multimodel ensemble strategy is adopted to encompass model errors. Two types of heat waves differently impacting human health - strong and extreme stress - are defined according to specified thresholds of thermal stress and duration. Heat wave number, frequency, duration and amplitude are derived for each type. Results reveal relatively strong correlations between the spatial distribution of strong and extreme heat wave amplitudes and mortality excess for the 2003 European summer. Projections suggest a steady increase and a northward extent of heat wave attributes in Europe. Strong stress heat wave frequencies could increase more than 40 days, lasting over 20 days more by 2075-2094. Amplitudes might augment up to 7 °C per heat wave day. Important increases in extreme stress heat wave attributes are also expected: up to 40 days in frequency, 30 days in duration and 4 °C in amplitude. We believe that with this information at hand policy makers and stakeholders on vulnerable populations to heat stress can respond more effectively to the future challenges imposed by climate warming.

  10. Parents as Teachers Health Literacy Demonstration project: integrating an empowerment model of health literacy promotion into home-based parent education.

    Science.gov (United States)

    Carroll, Lauren N; Smith, Sandra A; Thomson, Nicole R

    2015-03-01

    The Parents as Teachers (PAT) Health Literacy Demonstration project assessed the impact of integrating data-driven reflective practices into the PAT home visitation model to promote maternal health literacy. PAT is a federally approved Maternal, Infant, Early Childhood Home Visiting program with the goal of promoting school readiness and healthy child development. This 2-year demonstration project used an open-cohort longitudinal design to promote parents' interactive and reflective skills, enhance health education, and provide direct assistance to personalize and act on information by integrating an empowerment paradigm into PAT's parent education model. Eight parent educators used the Life Skills Progression instrument to tailor the intervention to each of 103 parent-child dyads. Repeated-measures analysis of variance, paired t tests, and logistic regression combined with qualitative data demonstrated that mothers achieved overall significant improvements in health literacy, and that home visitors are important catalysts for these improvements. These findings support the use of an empowerment model of health education, skill building, and direct information support to enable parents to better manage personal and child health and health care. PMID:24957219

  11. Projected global health impacts from severe nuclear accidents: Conversion of projected doses to risks on a global scale: Experience from Chernobyl releases

    International Nuclear Information System (INIS)

    Best estimates of possible additional health effects were projected for the Northern Hemisphere: (1) over the next 50 years, up to 28 thousand radiation-induced fatal cancers, compared to an expected 600 million cancer deaths FR-om natural or spontaneous causes; (2) over the next year, up to 700 additional cases of severe mental retardation, compared to a normal expectation of 340 thousand cases; and (3) in the first generation, up to 1.9 thousand radiation-induced genetic disorders, compared to 180 million naturally-occurring cases. The possibility of zero health effects at very low doses and dose rates cannot be excluded. Due to the very large numbers of naturally-occurring health effects, it is unlikely that any additional health effects will be demonstrable except, perhaps, for the more highly exposed population in the immediate vicinity of Chernobyl. 13 refs., 4 figs., 6 tabs

  12. Projected global health impacts from severe nuclear accidents: Conversion of projected doses to risks on a global scale: Experience from Chernobyl releases

    International Nuclear Information System (INIS)

    Best estimates of possible additional health effects were projected for the Northern Hemisphere: (1) over the next 50 years, up to 28 thousand radiation-induced fatal cancers, compared to an expected 600 million cancer deaths from natural or spontaneous causes; (2) over the next year, up to 700 additional cases of severe mental retardation, compared to a normal expectation of 340 thousand cases; and (3) in the first generation, up to 1.9 thousand radiation-induced genetic disorders, compared to 180 million naturally-occurring cases. The possibility of zero health effects at very low doses and dose rates cannot be excluded. Due to the very large numbers of naturally-occurring health effects, it is unlikely that any additional health effects will be demonstrable except, perhaps, for the more highly exposed population in the immediate vicinity of Chernobyl. 13 refs., 4 figs., 6 tabs

  13. A library for the twenty-first century: the Galter Health Sciences Library's renovation and expansion project.

    Science.gov (United States)

    Shedlock, J; Ross, F

    1997-04-01

    A renovation and expansion project at the Galter Health Sciences Library of Northwestern University strikes a balance between traditional and future libraries, library ambiance and high technology, old and new. When guided by a vision of future building use, renovation projects can succeed in meeting many institutional goals as a viable alternative to new library buildings. Issues addressed include planning considerations, architectural history, library design, building features, information technology considerations, and ideal library space design when new construction is not possible.

  14. A library for the twenty-first century: the Galter Health Sciences Library's renovation and expansion project.

    OpenAIRE

    Shedlock, J; Ross, F.

    1997-01-01

    A renovation and expansion project at the Galter Health Sciences Library of Northwestern University strikes a balance between traditional and future libraries, library ambiance and high technology, old and new. When guided by a vision of future building use, renovation projects can succeed in meeting many institutional goals as a viable alternative to new library buildings. Issues addressed include planning considerations, architectural history, library design, building features, information ...

  15. Health effects of Chernobyl accident. A WHO·IPHECA pilot project

    International Nuclear Information System (INIS)

    IPHECA (International Programme on Health Effects of Chernobyl Accident) made in 1991 includes the projects for thyroid, hematology, fetal exposure, registration for epidemiological examination and oral hygiene in Belarus. Following conclusions have been obtained by the Programme. One of serious health effects was the increase of registered diseases independent on radiation. This was mainly derived from socio-psychological effects, which were conceivably independent on direct radiation exposure. Rapid increase of thyroid cancer of children was observed in the contaminated areas, especially in Belarus. The total number of the patients in 3 countries was 565 by 1994. No significant increase of leukemia and other hematological diseases was seen. There were some data suggesting that fetal exposure resulted in mental or behavior abnormalities of newborns, which could not be fully understood because of lack of the radiological data. No difference was observed in oral diseases in Belarus and other regions. These findings can help to make the guidelines for planning and developing the future investigations and examinations. (H.O.)

  16. How advocates use health economic data and projections: the Irish experience.

    LENUS (Irish Health Repository)

    Murray, Eugene

    2009-07-01

    Approximately 30,000 people die in Ireland each year. Currently over 6000 people access specialist palliative care services annually, a figure that is projected to rise to 12,500 by 2016. In 2006, the Irish Hospice Foundation entered a joint advocacy alliance with the Irish Cancer Society and the Irish Association for Palliative Care. By speaking with one voice and using quality data, these three national voluntary groups were able to influence government and social partners to address clearly identified regional inequities in the provision of palliative care services. Over the past three years, there has been significant public investment in palliative care services, culminating in the recent publication by the national health agency of a five-year plan for a comprehensive national palliative care service. However, the sudden economic downturn in 2008 and the severe deterioration of public finances threaten the implementation of the plan. New services can only be developed if there is strong evidence to illustrate that they are cost-effective in delivering patient care. Having reviewed the international evidence, the joint advocacy group has used this economic evidence to strengthen the case that the development of palliative care services can actually save money in health budgets. The campaign mounted by the joint advocacy group was greatly facilitated by the existence of good data and an agreed evidence-based policy on what constitutes a comprehensive service.

  17. Collaboration, Participation and Technology: The San Joaquin Valley Cumulative Health Impacts Project

    Directory of Open Access Journals (Sweden)

    Jonathan K. London

    2011-11-01

    Full Text Available Community-university partnerships have been shown to produce significant value for both sets of partners by providing reciprocal learning opportunities, (rebuilding bonds of trust, and creating unique venues to formulate and apply research that responds to community interests and informs collaborative solutions to community problems. For such partnerships to be mutually empowering, certain design characteristics are necessary. These include mutual respect for different modes and expressions of knowledge, capacity-building for all parties, and an environment that promotes honest and constructive dialogue about the inevitable tensions associated with the interplay of power/knowledge. This article explores an innovative case of community-university partnerships through participatory action research involving a coalition of environmental justice and health advocates, the San Joaquin Valley Cumulative Health Impacts Project, and researchers affiliated with the University of California, Davis. In particular, we examine how participatory GIS and community mapping can promote co-learning and interdependent science. Keywords Community-based participatory research, environmental justice, Public Participation Geographic Information System

  18. Nonevent stress contributes to mental health disparities based on sexual orientation: evidence from a personal projects analysis.

    Science.gov (United States)

    Frost, David M; LeBlanc, Allen J

    2014-09-01

    This study examined the role of nonevent stress--in the form of frustrated personal project pursuits in the arenas of relationships and work--as a contributing factor to mental health disparities between heterosexual and lesbian, gay, and bisexual (LGB) populations. A purposive sample of 431 LGB (55%) and heterosexually identified (45%) individuals living in the United States and Canada completed the Personal Project Inventory by describing and rating core personal projects they were pursuing. The intensity of perceived barriers to the achievement of relationship- and work-related personal projects served as indicators nonevent stress. Hierarchical linear regression models tested the hypothesis that nonevent stress contributes to the association between sexual orientation and two indicators of mental health: depressive symptoms and psychological well-being. LGB individuals had significantly more depressive symptoms and lower levels of psychological well-being than heterosexuals. Indicators of nonevent stress were significantly associated with mental health outcomes and their inclusion in models attenuated sexual orientation differences in mental health. The critical indirect pathway leading from sexual minority status to mental health occurred via barriers to relationship projects from interpersonal sources. This research suggests that nonevent stress because of structural and interpersonal stigma may contribute to mental health disparities between LGB and heterosexual individuals. The findings have important implications for policy reform around same-sex relationship recognition and workplace discrimination. Future research and clinical work will benefit by expanding existing foci on stress to include nonevent stressors to better understand and address mental health problems, particularly in LGB populations. PMID:25265219

  19. Project INTEGRATE - a common methodological approach to understand integrated health care in Europe

    Directory of Open Access Journals (Sweden)

    Lucinda Cash-Gibson

    2014-12-01

    Full Text Available Background: The use of case studies in health services research has proven to be an excellent methodology for gaining in-depth understanding of the organisation and delivery of health care. This is particularly relevant when looking at the complexity of integrated healthcare programmes, where multifaceted interactions occur at the different levels of care and often without a clear link between the interventions (new and/or existing and their impact on outcomes (in terms of patients health, both patient and professional satisfaction and cost-effectiveness. Still, integrated care is seen as a core strategy in the sustainability of health and care provision in most societies in Europe and beyond. More specifically, at present, there is neither clear evidence on transferable factors of integrated care success nor a method for determining how to establish these specific success factors. The drawback of case methodology in this case, however, is that the in-depth results or lessons generated are usually highly context-specific and thus brings the challenge of transferability of findings to other settings, as different health care systems and different indications are often not comparable. Project INTEGRATE, a European Commission-funded project, has been designed to overcome these problems; it looks into four chronic conditions in different European settings, under a common methodology framework (taking a mixed-methods approach to try to overcome the issue of context specificity and limited transferability. The common methodological framework described in this paper seeks to bring together the different case study findings in a way that key lessons may be derived and transferred between countries, contexts and patient-groups, where integrated care is delivered in order to provide insight into generalisability and build on existing evidence in this field. Methodology: To compare the different integrated care experiences, a mixed-methods approach has

  20. Project INTEGRATE - a common methodological approach to understand integrated health care in Europe

    Directory of Open Access Journals (Sweden)

    Lucinda Cash-Gibson

    2014-12-01

    Full Text Available Background: The use of case studies in health services research has proven to be an excellent methodology for gaining in-depth understanding of the organisation and delivery of health care. This is particularly relevant when looking at the complexity of integrated healthcare programmes, where multifaceted interactions occur at the different levels of care and often without a clear link between the interventions (new and/or existing and their impact on outcomes (in terms of patients health, both patient and professional satisfaction and cost-effectiveness. Still, integrated care is seen as a core strategy in the sustainability of health and care provision in most societies in Europe and beyond. More specifically, at present, there is neither clear evidence on transferable factors of integrated care success nor a method for determining how to establish these specific success factors. The drawback of case methodology in this case, however, is that the in-depth results or lessons generated are usually highly context-specific and thus brings the challenge of transferability of findings to other settings, as different health care systems and different indications are often not comparable. Project INTEGRATE, a European Commission-funded project, has been designed to overcome these problems; it looks into four chronic conditions in different European settings, under a common methodology framework (taking a mixed-methods approach to try to overcome the issue of context specificity and limited transferability. The common methodological framework described in this paper seeks to bring together the different case study findings in a way that key lessons may be derived and transferred between countries, contexts and patient-groups, where integrated care is delivered in order to provide insight into generalisability and build on existing evidence in this field.Methodology: To compare the different integrated care experiences, a mixed-methods approach has

  1. Perceived ill-health and health seeking behavior in two communities in the nam theun 2 hydroelectric project area in Lao People's Democratic Republic

    Institute of Scientific and Technical Information of China (English)

    Sayasone S; Erlanger TE; Kaul S; Sananikhom P; Tanner M; Utzinger J; Odermatt P

    2009-01-01

    Objective:To compare perceived ill-health and health seeking behavior between two communities affected by the large Nam Theun 2 hydroelectric project in central Lao People's Democratic Republic (PDR).Methods:Two different affected areas:Nakai plateaubeing remote,sparcely populated and mountainous,and Xe Bang Fai lowland plains,more densely populated and comparatively affluent were included.Data were obtained from two cross-sectional household-based health and socio-economic surveys.Results:We found pronounced differ-ences in the frequency of self-reported fever,cough,headache and myalgia according to location.On the Na-kai plateau,45.1 % of the individuals with ill-health report (recall period:2 weeks)went to a local health volunteer compared to only 7.2 % in the Xe Bang Fai area (P <0.001).In Nakai,there were disproportion-ately more illiterates seeking help from local health volunteers when compared to those who attended at least primary schooling (49.2 % versus 17.5 %,P <0.01).Self-medication with antimalarials was more common in Xe Bang Fai than on Nakai (32.3 % versus 7.0 %,P <0.001).The mean amount of money spent per health consultation was US $1.7 in Nakai and US $7.2 in Xe Bang Fai.Conclusion:The observed differ-ences in self-reported ill-health and health seeking behavior among these two Lao communities need to be con-sidered when implementing setting-specific mitigation measures as part of the public health action plan of the Nam Theun 2 hydroelectric project.

  2. Promotion of the health of rural women towards safe motherhood--an intervention project in northeast Thailand.

    Science.gov (United States)

    Saowakontha, S; Pongpaew, P; Vudhivai, N; Tungtrongchitr, R; Sanchaisuriya, P; Mahaweerawat, U; Laohasiriwong, W; Intarakhao, C; Leelapanmetha, P; Chaisiri, K; Vatanasapt, V; Merkle, A; Schelp, F P

    2000-01-01

    An intervention project focusing on the health of women in the reproductive age was conducted in three districts of Khon Kaen Province, northeast Thailand between 1991 and 1996. Main emphasis was placed on improving reproductive health, the nutritional status including the iron deficiency anemia (IDA) as well as iodine deficiency disorders (IDD), and the parasitic diseases liver fluke (Opisthorchis viverrini) and hookworm. For implementation a community based Primary Health Care approach was used including the training of health officials in health matters, primary health care workers and villagers as well as enhancing health education and the dissemination of health information. The health delivery system was encouraged to take appropriate actions such as in the treatment of parasitic diseases and the control of IDA and IDD. Monitoring was done on a regular basis. The outcome of the project was assessed by comparing baseline data compiled from a random sample of the target population with the results of the final evaluation. An attempt to compare results obtained from villages within and outside of the project area failed most probably because of spill over effects. A number of important indicators on family planning and mother and child health care improved during the time the project was implemented; this included practising family planning, and participation in antenatal care. Also the proportion of females becoming pregnant for the first time when 20 years or older increased. Child-raising also improved in that almost all females gave colostrum to their babies by this time. Almost 75% of the women breast-fed their children. Improvements occurred in the nutritional status as far as the micronutrients iron and iodine were concerned, however the overall nutritional status of females did not change, but a rather high proportion of females were found to be overnourished. The project failed in reducing abortion and the proportion of females becoming pregnant when

  3. The NADI program and the JOICFP integrated project: partners in delivering primary health care.

    Science.gov (United States)

    Arshat, H; Othman, R; Kuan Lin Chee; Abdullah, M

    1985-10-01

    The NADI program (pulse in Malay) was initially launched as a pilot project in 1980 in Kuala Lumpur, Malaysia. It utilized an integrated approach involving both the government and the private sectors. By sharing resources and expertise, and by working together, the government and the people can achieve national development faster and with better results. The agencies work through a multi-level supportive structure, at the head of which is the steering committee. The NADI teams at the field level are the focal points of services from the various agencies. Members of NADI teams also work with urban poor families as well as health groups, parents-teachers associations, and other similar groups. The policy and planning functions are carried out by the steering committee, the 5 area action committees and the community action committees, while the implementation function is carried out by the area program managers and NADI teams. The chairman of each area action committee is the head of the branch office of city hall. Using intestinal parasite control as the entry point, the NADI Integrated Family Development Program has greatly helped in expanding inter-agency cooperation and exchange of experiences by a coordinated, effective and efficient resource-mobilization. The program was later expanded to other parts of the country including the industrial and estate sectors. Services provided by NADI include: comprehensive health services to promote maternal and child health; adequate water supply, proper waste disposal, construction of latrines and providing electricity; and initiating community and family development such as community education, preschool education, vocational training, family counseling and building special facilities for recreational and educational purposes.

  4. Model for collaboration: a rural medicine and academic health center teleradiology project

    Science.gov (United States)

    Van Slyke, Mark A.; Eggli, Douglas F.; Prior, Fred W.; Salmon, William; Pappas, Gregory; Vanatta, Fred; Goldfetter, Warren; Hashem, Said

    1996-05-01

    A pilot project was developed to explore the role of subspecialty radiology support to rural medicine sites over a long-distance network. A collaborative relationship between 2 rural radiology practices and an academic health was established. Project objectives included: (1) Does the subspecialty consultation significantly change diagnosis patterns at the rural site? (2) Is there value added as measured by improved clinical care or an overall decreased cost of care? (3) Can a collaborative model be economically self-supportive? (4) Does the collaborative model encourage and support education and collegial relationships? Two rural hospitals were selected based on the level of imaging technology and willingness to cooperate. Image capture and network technology was chosen to make the network process transparent to the users. DICOM standard interfaces were incorporated into existing CT and MRI scanners and a film digitizer. Nuclear medicine images were transferred and viewed using a proprietary vendor protocol. Relevant clinical data was managed by a custom designed PC based Lotus Notes application (Patient Study Tracking System: PaSTS) (Pennsylvania Blue Shield Institute). All data was transferred over a Frame Relay network and managed by the Pennsylvania Commonwealth sponsored PA Health Net. Images, other than nuclear medicine, were viewed on a GE Advantage viewing station using a pair of 2 X 2.5 K gray scale monitors. Patient text data was managed by the PaSTS PC and displayed on a separate 15' color monitor. A total of 476 radiology studies were networked into the AHC. Randomly chosen research studies comprised 82% of the case work. Consultative and primary read cases comprised 17% and 1% respectively. The exercise was judged effective by both rural sites. Significant findings and diagnoses were confirmed in 73% of cases with discrepant findings in only 4%. One site benefited by adopting more advanced imaging techniques increasing the sophistication of radiology

  5. Paroxysmal nocturnal hemoglobinuria. Enhanced stimulation of platelets by the terminal complement components is related to the lack of C8bp in the membrane.

    Science.gov (United States)

    Blaas, P; Berger, B; Weber, S; Peter, H H; Hänsch, G M

    1988-05-01

    Recently, a protein isolated from the membrane of human E, the so-called C8 binding protein (C8bp), has been described. C8bp is characterized as a 65-kDa protein that binds to C8 and inhibits the C5b-9-mediated lysis in a homologous system. In the present study, membranes of peripheral blood cells were tested for the presence of C8bp by SDS-PAGE and immunoblotting. In all cells a protein band reacting with anti-C8bp was seen, the Mr, however, was only about 50 kDa. To further analyze the 50-kDa protein, we isolated the protein by phenol-water extraction and isoelectric focusing from papain-treated platelets. The isolated protein behaved similar to the E-derived C8bp: it inhibited the lysis of model target cells by C5b-9. To examine the function of C8bp in platelets, we tested platelets from patients suffering from paroxysmal nocturnal hemoglobinuria (PNH). These platelets were deficient in C8bp, being in accordance with their higher lytic susceptibility in vitro. In response to sublytic C5b-9 doses, the PNH platelets released considerably more serotonin and thromboxane B2 than normal platelets. By addition of purified C8bp, the thromboxane B2 release was suppressed, indicating that C8bp not only restricts the lytic complement attack, but also regulates the C5b-9-mediated stimulation of target cells. Thus, lack of C8bp might not only result in enhanced hemolysis, but also in enhanced stimulation of platelets, which in turn might contribute to the thrombotic complications seen in some PNH-type III patients.

  6. Enhancing the health of women living with HIV: the SMART/EST Women's Project

    Directory of Open Access Journals (Sweden)

    Stephen M Weiss

    2011-02-01

    Full Text Available Stephen M Weiss1, Jonathan N Tobin2, Michael Antoni1, Gail Ironson1, Mary Ishii1, Anita Vaughn2, Andrea Cassells2, Deborah Jones1, Neil Schneiderman1, Elizabeth Brondolo3, Arthur LaPerriere1, Maria Lopez1, Olga Villar-Loubet1, Joanne Camille2, Mahendra Kumar1, J Bryan Page1, SMART/EST Women's Project Team*1University of Miami, Miami, FL, USA; 2Clinical Directors Network, New York, NY, USA; 3St Johns University, Queens, NY, USA; *The SMART/EST Womens' Project Team: DeVieux J, Jean-Gilles M, Gousse Y, Alexander K, Bustamonte V, Lopez E, Casani J, Stanley H, Asthana D, Van Splunteren F, Goldstein A, Nasajon R, Wiesner Y, Zukerman M, Segal-Isaacson CJ, Romanowsky A, Masheb R, Coma C, Ubiera M, D'Andrea SM, Ittai N.Abstract: The principal objective of these multisite studies (Florida, New York, New Jersey: epicenters for human immunodeficiency virus [HIV] among women was to develop and implement effective combinations of behavioral interventions to optimize the health status of the most neglected and understudied population affected by the acquired immunodeficiency syndrome (AIDS epidemic in the United States: poor women of color living with HIV. The two studies enrolled nearly 900 women randomly assigned to “high intensity” (cognitive–behavioral stress management training combined with expressive–supportive therapy [CBSM]+ group or “low intensity” (individual psychoeducational program treatment conditions over a period of 9 years. The initial study of the stress management and relaxation training/expressive–supportive therapy (SMART/EST Women's Project (SWP I focused on reducing depression and anxiety, as well as improving self-efficacy and overall quality of life for women with case-defined AIDS. Findings from this study demonstrated the utility of CBSM+ in reducing distress (depression, anxiety and denial, while improving social support, self-efficacy, coping skills, and quality of life. The second study (SWP II, which included all

  7. The role of short-term volunteers in a global health capacity building effort: the Project HOPE-GEMC experience

    OpenAIRE

    Rominski, Sarah D; Yakubu, Jamila; Oteng, Rockefeller A.; Peterson, Matt; Tagoe, Nadia; Bell, Sue Anne

    2015-01-01

    Background Increasingly, medical students and practicing clinicians are showing interest in traveling to low-income settings to conduct research and engage in clinical rotations. While global health activities have the potential to benefit both the individual and the host, there can be challenges. We describe one way to harmonize the desire of volunteers to have a meaningful impact on the health care delivery system in a developing country with the needs of that country. Methods The Project H...

  8. 2D QSAR study for gemfibrozil glucuronide as the mechanism-based inhibitor of CYP2C8

    Directory of Open Access Journals (Sweden)

    N Taxak

    2013-01-01

    Full Text Available Mechanism-based inhibition of cytochrome P450 involves the bioactivation of the drug to a reactive metabolite, which leads to cytochrome inhibition via various mechanisms. This is generally seen in the Phase I of drug metabolism. However, gemfibrozil (hypolipidemic drug leads to mechanism-based inhibition after generating glucuronide conjugate (gemfibrozil acyl-β-glucuronide in the Phase II metabolism reaction. The mechanism involves the covalent binding of the benzyl radical (generated from the oxidation of aromatic methyl group in conjugate to the heme of CYP2C8. This article deals with the development of a 2D QSAR model based on the inhibitory potential of gemfibrozil, its analogues and corresponding glucuronide conjugates in inhibiting the CYP2C8-catalysed amodiaquine N-deethylation. The 2D QSAR model was developed using multiple linear regression analysis in Accelrys Discovery Studio 2.5 and helps in identifying the descriptors, which are actually contributing to the inhibitory potency of the molecules studied. The built model was further validated using leave one out method. The best quantitative structure activity relationship model was selected having a correlation coefficient (r of 0.814 and cross-validated correlation coefficient (q 2 of 0.799. 2D QSAR revealed the importance of volume descriptor (Mor15v, shape descriptor (SP09 and 3D matrix-based descriptor (SpMax_RG in defining the activity for this series of molecules. It was observed that volume and 3D matrix-based descriptors were crucial in imparting higher potency to gemfibrozil glucuronide conjugate, as compared with other molecules. The results obtained from the present study may be useful in predicting the inhibitory potential (IC 50 for CYP2C8 inhibition of the glucuronide conjugates of new molecules and compare with the standard gemfibrozil acyl-β-glucuronide (in terms of pIC 50 values in early stages of drug discovery and development.

  9. 黏质沙雷氏菌C8-8几丁质酶基因的克隆与表达%Cloning and expression of a chitinase gene from Serratia marcescens strain C8-8

    Institute of Scientific and Technical Information of China (English)

    刘邮洲; 罗楚平; 刘永锋; 陈志谊

    2012-01-01

    利用PCR方法从黏质沙雷氏菌(Serratia marcescens)C8-8中克隆到编码几丁质酶的chiA基因,大小为1692bp,推测其编码一条长563个氨基酸的多肽链,分子量约为60900.同源分析研究结果表明从C8-8中克隆的chiA基因序列与黏质沙雷氏菌株141(DQ990373.1)和14041菌株(DQ493896.1)的chiA基因序列相似性最高,达到99%.结构域分析结果表明从C8-8中克隆的chiA基因N末端(23AA)存在典型的信号肽序列,C端存在另外两个结构域,即PKD区(73AA)和几丁质酶催化区(387AA).采用大肠杆菌表达系统重组表达chiA基因,结果表明重组菌株在几丁质诱导培养基上能产生透明的水解圈.采用SDS-PAGE电泳分析,结果表明chiA重组表达产物的相对分子质量约为60000,与预测分子量大小基本一致.初步提纯后,生物活性试验结果表明该重组表达产物能水解几丁质,在几丁质培养基上产生透明的水解圈.%An open reading frame encoding chiA gene was cloned from the Serratia marcescens strain C8-8 genomic DNA by PCR, with the length of 1 692 bp. Its sequence was 99% identical with chiA sequences of Serratia marcescens 141 and 14041. Domain analysis showed that the cloned chiA gene involved a typical signal peptide sequence at N-terraination (23 AA), and PKD domain (73 AA) and chitinase catalytic domain (387 AA) at C-termination. The PCR fragment was digested and cloned into plasmid pET28a to construct plasmid pET28a-ChiA, which was then transformed into expression host Escherichia. coli DH3. The recombined strain DH3 ChiA could yield transparent hydrolyzed zone on the colloidal chi-tin plate induced by isopropyl-1 -thiogalactopyranoside (IPTG). A protein with molecular weight about 60 000 was expressed by DH3 ChiA, and could also yield a hydrolyzed rone on the colloidal chitin plate. It indicated that chiA gene from C8-8 could be utilized as a potential biological factor for control of fungi.

  10. Analysis of Causes Leading to High Bromine Number of C8+Aromatics and Short Clay Service Life and Countermeasures Proposed

    Institute of Scientific and Technical Information of China (English)

    Li Yousong; Ni Xiaoliang; Yan Jun

    2007-01-01

    After comparing the operating status of other catalytic reforming units and evaluation of the side-cut stream tests,the refinery investigated the influence of the feedstock property,clay types,and operating regime of the clay tower and catalytic reforming unit on the service life of the clay.Test results had revealed that the low potential aromatic content of the reformer feed and high operating severity were the critical causes leading to high bromine number of the C8+ aromatics feed for the PX unit and the shortened service life of clay.This article also puts forward the corresponding remedial measures.

  11. Australian rural football club leaders as mental health advocates: an investigation of the impact of the Coach the Coach project

    Directory of Open Access Journals (Sweden)

    Dobell Jennifer

    2010-05-01

    Full Text Available Abstract Background Mental ill health, especially depression, is recognised as an important health concern, potentially with greater impact in rural communities. This paper reports on a project, Coach the Coach, in which Australian rural football clubs were the setting and football coaches the leaders in providing greater mental health awareness and capacity to support early help seeking behaviour among young males experiencing mental health difficulties, especially depression. Coaches and other football club leaders were provided with Mental Health First Aid (MHFA training. Method Pre-post measures of the ability of those club leaders undertaking mental health training to recognise depression and schizophrenia and of their knowledge of evidence supported treatment options, and confidence in responding to mental health difficulties were obtained using a questionnaire. This was supplemented by focus group interviews. Pre-post questionnaire data from players in participating football clubs was used to investigate attitudes to depression, treatment options and ability to recognise depression from a clinical scenario. Key project stakeholders were also interviewed. Results Club leaders (n = 36 who were trained in MHFA and club players (n = 275 who were not trained, participated in this evaluation. More than 50% of club leaders who undertook the training showed increased capacity to recognise mental illness and 66% reported increased confidence to respond to mental health difficulties in others. They reported that this training built upon their existing skills, fulfilled their perceived social responsibilities and empowered them. Indirect benefit to club players from this approach seemed limited as minimal changes in attitudes were reported by players. Key stakeholders regarded the project as valuable. Conclusions Rural football clubs appear to be appropriate social structures to promote rural mental health awareness. Club leaders, including many

  12. Fukushima Daiichi nuclear power plant accident and the project of prefectural health management survey

    International Nuclear Information System (INIS)

    The Project in the title after the Accident (Mar. 11, 2011) formally started in September in Fukushima Medical University in contract with the Prefecture on the national fund, of which progress and future aspect are reported. Based on a preliminary study in June, the subsequent fundamental investigation was conducted on all prefectural residents from August with questionnaire to see individual's health state and to estimate their accumulated maximal dose (mSv/4 months after the Accident). The preliminary study above was conducted for 29 thousands residents having been supposedly exposed to high dose at regions of Yamakiya, Namie and Iitate, 15 thousands (52%) of whom replied, where 99.3% were exposed to <10 mSv with the maximum of 23.0 mSv. In the fundamental study, until the end of May, 2012, 440 thousands replies (22%) were obtained from 2.05 million postal questionnaire mails sent, whose analysis was not finished, yet the results were retuned to individuals in due order of analysis completion. Another detailed investigation started almost simultaneously, which contained examinations of ultrasonic (US) thyroid testing for residents younger than age 18 y, of detailed health and mental state/life habit of 21 thousands people in the evacuation area, and of expectant/nursing mothers. Preliminarily, the internal exposure dose rate of thyroid was found to be 0.1 mcSv/h in one subject and <0.04 in 99% of 1,080 children in the Prefecture (Mar. 24-30), and US test of 38 thousands in the evacuation area revealed 0.5% of children were necessary for secondary examination due to benign lesions in the organ. To expectant/nursing mothers, questionnaire was performed asking about the health state during pregnancy, childbirth, mental health, etc. Reply was obtained in 55% within 2011 and follow-up has been conducted when judged to be necessary. Tasks derived from all matters described above include various things, of which continued long term follow-up supports are necessary. (T.T.)

  13. Working Group 7.0 Environmental Transport and Health Effects, Chernobyl Studies Project. Progress report, October 1994 -- March 1995

    International Nuclear Information System (INIS)

    This document presents the details from the working group 7.0 Chernobyl Studies Project. This working group looked at the environmental transport and health effects from the fallout due to the meltdown of Chernobylsk-4 reactor. Topics include: hydrological transport; chromosome painting dosimetry; EPR, TL and OSL dosimetry; stochastic effects; thyroid studies; and leukemia studies

  14. Cancer survival in the elderly: Effects of socio-economic factors and health care system features (ELDCARE project)

    NARCIS (Netherlands)

    M. Vercelli (Marina); R. Lillini (Roberto); R. Capocaccia (Riccardo); A. Micheli; J.W.W. Coebergh (Jan Willem); M.J. Quinn (M.); C. Martinez-Garcia (Carmen); A. Quaglia (Alberto); W. Oberaigner; J. Ajmová (J.); T. Aareleid (T.); J. Palo (Jukka); T. Hakulinen (Timo); P. Grosclaude (P.); H. Ziegler (H.); L. Tryggvadottir (Laufey); F. Langmark (F.); A. Andersen; M. Bielska-Lasota (Magdalena); M.A. Pinheiro (Magda Avelar); I. Pleško (I.); V. Pompe-Kirn (V.); P. Ecimovic (P.); T. Möller (Thomas); J.-M. Lutz (J.)

    2006-01-01

    textabstractThe purpose of the ELDCARE project is to study differences in cancer survival for elderly patients by country, taking into account the socio-economic conditions and the characteristics of health care systems at the ecological level. Fifty-three European cancer registries, from 19 countri

  15. Working Group 7.0 Environmental Transport and Health Effects, Chernobyl Studies Project. Progress report, October 1994 -- March 1995

    Energy Technology Data Exchange (ETDEWEB)

    Anspaugh, L.R.; Hendrickson, S.M. [eds.

    1995-06-01

    This document presents the details from the working group 7.0 Chernobyl Studies Project. This working group looked at the environmental transport and health effects from the fallout due to the meltdown of Chernobylsk-4 reactor. Topics include: hydrological transport; chromosome painting dosimetry; EPR, TL and OSL dosimetry; stochastic effects; thyroid studies; and leukemia studies.

  16. Using CLIL to Enhance Pupils' Experience of Learning and Raise Attainment in German and Health Education: A Teacher Research Project

    Science.gov (United States)

    Mearns, Tessa L.

    2012-01-01

    This paper describes and evaluates an action research project carried out by a teacher in an English comprehensive school, where a class of 13- to 14-year-olds was taught personal, social and health education and German through content-language integrated learning (CLIL) over a six-week period. The purpose of the study was to explore how CLIL…

  17. Public librarians as a resource for promoting health: results from the Health for Everyone in Libraries Project (HELP) librarian survey.

    Science.gov (United States)

    Linnan, Laura A; Wildemuth, Barbara M; Gollop, Claudia; Hull, Peggy; Silbajoris, Christie; Monnig, Ruth

    2004-04-01

    Public libraries are located in all communities, and two thirds of adults visit one each year. Libraries give the public access to computers and the Internet, and librarians offer technical assistance for accessing information. The interests and training needs of public librarians for assisting the public in accessing health information have not been addressed. One public library/librarian in each North Carolina county was randomly selected to complete a written questionnaire to assess health-related information services and librarians' skills for providing these services. 84% of librarians (83/99) completed the questionnaire. Results indicate that librarians answer more than 10 health-related questions per week, feel moderately comfortable answering these questions, and are very interested in receiving additional training for addressing health-related questions. Creating public library/public health partnerships holds much promise for enhancing the ability of community members to access desired health information.

  18. Empirically derived dietary patterns and health-related quality of life in the SUN project.

    Directory of Open Access Journals (Sweden)

    Cristina Ruano

    Full Text Available OBJECTIVE: The analysis of dietary patterns has become a valuable tool to examine diet-disease relationships but little is known about their effects on quality of life. Our aim was to ascertain the association between major dietary patterns and mental and physical quality of life after 4 years of follow-up. MATERIALS AND METHODS: This analysis included 11,128 participants from the "Seguimiento Universidad de Navarra" (SUN cohort. Dietary habits were assessed using a validated food-frequency questionnaire. Factor analysis was used to derive dietary patterns. Quality of life was measured with the validated Spanish version of the SF-36 Health Survey. RESULTS: Two major dietary patterns were identified, the 'Western' dietary pattern (rich in red meats, processed pastries and fast-food and the "Mediterranean" dietary pattern (high in fruits, vegetables and olive oil. After controlling for confounders, the Western dietary pattern was associated with quality of life in all domains. The magnitude of these differences between the subjects in the highest (quintile 5 and the lowest quintile of adherence to the Western pattern ranged from -0.8 (for mental health to -3.5 (for vitality. On the contrary, the Mediterranean dietary pattern was associated with better quality of life domains: differences ranged from +1.3 (for physical functioning to +3.4 (for vitality when comparing extreme quintiles of adherence. Additional sensitivity analyses did not change the reported differences. CONCLUSIONS: Whereas baseline adherence to a Western dietary pattern was inversely associated with self-perceived quality of life after 4 years of follow-up, baseline adherence to a Mediterranean dietary pattern was directly associated with better scores in quality of life four years later in the SUN Project.

  19. Chernobyl Studies Project - working group 7.0 environmental transport and health effects. Progress report, October 1993--January 1994

    Energy Technology Data Exchange (ETDEWEB)

    Hendrickson, S.M. [ed.

    1994-03-01

    The DOE-funded Chernobyl Studies Project was begun as part of a cooperative agreement between the US and the former USSR, (quote) To develop jointly methods to project rapidly the health effects of any future reactor accident (quote). Most of the initial tasks for this project are completed or near completion. The focus has now turned primarily to the issue of health effects from the Chernobyl accident. Currently, we are extensively engaged in case-control and cohort studies of thyroid diseases among Belarussian children and in the Ukraine. A major part of the effort is providing methods and applications of dose reconstruction and providing support and equipment for the medical teams. This document contains reports on progress in the following task areas: Management; External Dose; Hydrological Transport; Chromosome Painting Dosimetry; Stochastic Effects; Thyroid Studies; and Leukemia Studies.

  20. Reflections from a Creative Community-Based Participatory Research Project Exploring Health and Body Image with First Nations Girls

    Directory of Open Access Journals (Sweden)

    Jennifer M. Shea PhD

    2013-02-01

    Full Text Available In Canada, Aboriginal peoples often experience a multitude of inequalities when compared with the general population, particularly in relation to health (e.g., increased incidence of diabetes. These inequalities are rooted in a negative history of colonization. Decolonizing methodologies recognize these realities and aim to shift the focus from communities being researched to being collaborative partners in the research process. This article describes a qualitative community-based participatory research project focused on health and body image with First Nations girls in a Tribal Council region in Western Canada. We discuss our project design and the incorporation of creative methods (e.g., photovoice to foster integration and collaboration as related to decolonizing methodology principles. This article is both descriptive and reflective as it summarizes our project and discusses lessons learned from the process, integrating evaluations from the participating girls as well as our reflections as researchers.

  1. Presenting evidence-based health information for people with multiple sclerosis: the IN-DEEP project protocol

    Directory of Open Access Journals (Sweden)

    Hill Sophie

    2012-03-01

    Full Text Available Abstract Background Increasingly, evidence-based health information, in particular evidence from systematic reviews, is being made available to lay audiences, in addition to health professionals. Research efforts have focused on different formats for the lay presentation of health information. However, there is a paucity of data on how patients integrate evidence-based health information with other factors such as their preferences for information and experiences with information-seeking. The aim of this project is to explore how people with multiple sclerosis (MS integrate health information with their needs, experiences, preferences and values and how these factors can be incorporated into an online resource of evidence-based health information provision for people with MS and their families. Methods This project is an Australian-Italian collaboration between researchers, MS societies and people with MS. Using a four-stage mixed methods design, a model will be developed for presenting evidence-based health information on the Internet for people with MS and their families. This evidence-based health information will draw upon systematic reviews of MS interventions from The Cochrane Library. Each stage of the project will build on the last. After conducting focus groups with people with MS and their family members (Stage 1, we will develop a model for summarising and presenting Cochrane MS reviews that is integrated with supporting information to aid understanding and decision making. This will be reviewed and finalised with people with MS, family members, health professionals and MS Society staff (Stage 2, before being uploaded to the Internet and evaluated (Stages 3 and 4. Discussion This project aims to produce accessible and meaningful evidence-based health information about MS for use in the varied decision making and management situations people encounter in everyday life. It is expected that the findings will be relevant to broader

  2. Implementing the Use of Rapid HIV Tests in Public Health Centers in Seoul: Results of a Pilot Project, 2014.

    Science.gov (United States)

    Kang, Cho Ryok; Bang, Ji Hwan; Cho, Sung-Il; Kim, Kui Nam; Lee, Hee-jin; Lee, Young Hwa; Ryu, Bo Yeong; Cho, Soo Kyung; Oh, Myoung-Don; Lee, Jong-Koo

    2016-03-01

    To determine whether rapid HIV tests in public health centers might encourage voluntary HIV testing, a pilot project was conducted in four selected public health centers in Seoul, 2014. During the period April 10 to November 28 of pilot project, 3,356 rapid tests were performed, and 38 were confirmed as positive. The monthly average numbers of voluntary HIV tests and HIV-positive cases were up to nine-fold and six-fold larger, respectively, than those of the period before application of the rapid HIV test. Among 2,051 examinees that completed questionnaires, 90.3% were satisfied. In conclusion, the use of rapid HIV tests in public health centers promoted voluntary HIV testing and was satisfactory for examinees. PMID:26955251

  3. Industrial Application of SKI-400D Catalyst for C8 Aromatics Isomerization%SKI-400D型C8芳烃异构化催化剂的工业应用

    Institute of Scientific and Technical Information of China (English)

    张振翼; 马新宾

    2007-01-01

    针对间二甲苯装置工况,开发了专用于生产间二甲苯的SKI-400D型C8芳烃异构化催化剂.该催化剂在中国石油化工股份有限公司北京燕山分公司聚酯事业部间二甲苯装置上替代SKI-500型催化剂.在主要设备不作改动的情况下.使装置产量由设计35.6 kt/a提高到40.0kt/a.收率由83.3%提高到91.0%.

  4. Assessment and prevention of acute health effects of weather conditions in Europe, the PHEWE project: background, objectives, design

    Directory of Open Access Journals (Sweden)

    Anderson Hugh

    2007-04-01

    Full Text Available Abstract Background The project "Assessment and prevention of acute health effects of weather conditions in Europe" (PHEWE had the aim of assessing the association between weather conditions and acute health effects, during both warm and cold seasons in 16 European cities with widely differing climatic conditions and to provide information for public health policies. Methods The PHEWE project was a three-year pan-European collaboration between epidemiologists, meteorologists and experts in public health. Meteorological, air pollution and mortality data from 16 cities and hospital admission data from 12 cities were available from 1990 to 2000. The short-term effect on mortality/morbidity was evaluated through city-specific and pooled time series analysis. The interaction between weather and air pollutants was evaluated and health impact assessments were performed to quantify the effect on the different populations. A heat/health watch warning system to predict oppressive weather conditions and alert the population was developed in a subgroup of cities and information on existing prevention policies and of adaptive strategies was gathered. Results Main results were presented in a symposium at the conference of the International Society of Environmental Epidemiology in Paris on September 6th 2006 and will be published as scientific articles. The present article introduces the project and includes a description of the database and the framework of the applied methodology. Conclusion The PHEWE project offers the opportunity to investigate the relationship between temperature and mortality in 16 European cities, representing a wide range of climatic, socio-demographic and cultural characteristics; the use of a standardized methodology allows for direct comparison between cities.

  5. Association of the C8orf13-BLK Region with Systemic Sclerosis in North-American and European Populations

    Science.gov (United States)

    Gourh, Pravitt; Agarwal, Sandeep K; Martin, Ezequiel; Divecha, Dipal; Rueda, Blanca; Bunting, Haley; Assassi, Shervin; Paz, Gene; Shete, Sanjay; McNearney, Terry; Draeger, Hilda; Reveille, John D; Radstake, T.R.D.J.; Simeon, Carmen P.; Rodriguez, Luis; Vicente, Esther; Gonzalez-Gay, Miguel A.; Mayes, Maureen D.; Tann, Filemon K.; Martin, Javier; Arnett, Frank C.

    2009-01-01

    Objective Genetic studies in the systemic sclerosis (SSc), an autoimmune disease that clinically manifests with dermal and internal organ fibrosis and small vessel vasculopathy, have identified multiple susceptibility genes including HLA-class II, PTPN22, IRF5, and STAT4 which have also been associated with other autoimmune diseases, such as systemic lupus erythematosus (SLE). These data suggest that there are common autoimmune disease susceptibility genes. The current report sought to determine if polymorphisms in the C8orf13-BLK region (chromosome 8p23.1-B lymphoid tyrosine kinase), which is associated with SLE, are associated also with SSc. Methods Two variants in the C8orf13-BLK region (rs13277113 & rs2736340) were tested for association with 1050 SSc cases and 694 controls of North Americans of European descent and replicated in a second series 589 SSc cases and 722 controls from Spain. Results The “T” allele at rs2736340 variant was associated with SSc in both the U.S. and Spanish case-control series (P=6.8×10−5, OR 1.27, 95%CI 1.1–1.4). The “A” allele at rs13277113 variant was associated with SSc in the U.S. series only (P=3.6×10−4, OR 1.32, 95%CI 1.1–1.6) and was significant in the combined analyses of the two series (P=2.0×10−3; OR 1.20, 95%CI 1.1–1.3). Both variants demonstrated an association with the anti-centromere antibody (P=2.2×10−6 and P=5.5×10−4, respectively) and limited SSc (P=3.3×10−5 and P=2.9×10−3, respectively) in the combined analysis. Peripheral blood gene expression profiles suggest that B-cell receptor and NFκB signaling are dysregulated based on the risk haplotype of these variants. Conclusion We identify and replicate the association of the C8orf13-BLK region as a novel susceptibility factor for SSc, placing it in the category of common autoimmune disease susceptibility genes. PMID:19796918

  6. Quantitative analysis of reinforcing phase in AlSi11/CrFe30C8 composite castings

    Directory of Open Access Journals (Sweden)

    A. Dulęba

    2011-07-01

    Full Text Available In this paper assessment of the morphology and segregation of the reinforcing phase based on optical quantitative analysis was achieved. Microscopic observation of AlSi11/CrFe30C8 composite gravity castings was carried out in electromagnetic field. The purpose of investigation was the analysis of current frequency influence supplying the inductor of electromagnetic field on segregation, quantity and morphology of reinforcement phase in aluminum matrix composite. Technological conception of investigations was based on assumption that chromium-iron matrix of particles dissolved in aluminum composite matrix and carbide phases became actual reinforcement of the composite. Gravity segregation was analyzed. Graphs containing distribution of reinforcing phase in metal matrix were shown.

  7. Design of a powered elevator control system. [powered elevator system for modified C-8A aircraft for STOL operation

    Science.gov (United States)

    Glende, W. L. B.

    1974-01-01

    The design, fabrication and flight testing of a powered elevator system for the Augmentor Wing Jet STOL Research Aircraft (AWJSRA or Mod C-8A) are discussed. The system replaces a manual spring tab elevator control system that was unsatisfactory in the STOL flight regime. Pitch control in the AWJSRA is by means of a single elevator control surface. The elevator is used for both maneuver and trim control as the stabilizer is fixed. A fully powered, irreversible flight control system powered by dual hydraulic sources was designed. The existing control columns and single mechanical cable system of the AWJSRA have been retained as has been the basic elevator surface, except that the elevator spring tab is modified into a geared balance tab. The control surface is directly actuated by a dual tandem moving body actuator. Control signals are transmitted from the elevator aft quadrant to the actuator by a linkage system that includes a limited authority series servo actuator.

  8. Desorption of dimethylformamide from Zn4O(C8H4O4)3 framework

    Science.gov (United States)

    Zhang, Lei; Hu, Yun Hang

    2011-02-01

    Both dimethylformamide (DMF) and diethylformamide (DEF) are important solvents for the synthesis of Zn4O(C8H4O4)3 framework (MOF-5). It is generally recognized that DMF molecules can be completely displaced by CH2Cl2 during the synthesis of MOF-5. Herein, however, it was found that the DMF molecules inside the pores of the MOF-5 framework cannot be displaced by CH2Cl2. The desorption of the DMF molecules from the pores, which requires a temperature of 100 °C or above, is the first order with activation energy of 56.38 kJ/mol. In contrast, DEF molecules can be completely displaced by CH2Cl2 during the synthesis of MOF-5, because DEF molecules cannot penetrate into the pores of the MOF-5 paste.

  9. Do vehicular emissions dominate the source of C6-C8 aromatics in the megacity Shanghai of eastern China?

    Institute of Scientific and Technical Information of China (English)

    Hongli Wang; Qian Wang; Jianmin Chen; Changhong Chen; Cheng Huang; Liping Qiao; Shengrong Lou

    2015-01-01

    The characteristic ratios of volatile organic compounds (VOCs) to i-pentane,the indicator of vehicular emissions,were employed to apportion the vehicular and non-vehicular contributions to reactive species in urban Shanghai.Two kinds of tunnel experiments,one tunnel with more than 90% light duty gasoline vehicles and the other with more than 60% light duty diesel vehicles,were carried out to study the characteristic ratios of vehicle-related emissions from December 2009 to January 2010.Based on the experiments,the characteristic ratios of C6-C8 aromatics to i-pentane of vehicular emissions were 0.53 ± 0.08 (benzene),0.70 ± 0.12 (toluene),0.41 ± 0.09 (m,p-xylenes),0.16 ± 0.04 (o-xylene),0.023 ± 0.011 (styrene),and 0.15 ± 0.02 (ethylbenzene),respectively.The source apportionment results showed that around 23.3% of C6-C8 aromatics in urban Shanghai were from vehicular emissions,which meant that the non-vehicular emissions had more importance.These findings suggested that emission control of non-vehicular sources,i.e.industrial emissions,should also receive attention in addition to the control of vehicle-related emissions in Shanghai.The chemical removal of VOCs during the transport from emissions to the receptor site had a large impact on the apportionment results.Generally,the overestimation of vehicular contributions would occur when the VOC reaction rate constant with OH radicals (kOH) was larger than that of the vehicular indicator,while for species with smaller kOH than the vehicular indicator,the vehicular contribution would be underestimated by the method of characteristic ratios.

  10. Do vehicular emissions dominate the source of C6-C8 aromatics in the megacity Shanghai of eastern China?

    Science.gov (United States)

    Wang, Hongli; Wang, Qian; Chen, Jianmin; Chen, Changhong; Huang, Cheng; Qiao, Liping; Lou, Shengrong; Lu, Jun

    2015-01-01

    The characteristic ratios of volatile organic compounds (VOCs) to i-pentane, the indicator of vehicular emissions, were employed to apportion the vehicular and non-vehicular contributions to reactive species in urban Shanghai. Two kinds of tunnel experiments, one tunnel with more than 90% light duty gasoline vehicles and the other with more than 60% light duty diesel vehicles, were carried out to study the characteristic ratios of vehicle-related emissions from December 2009 to January 2010. Based on the experiments, the characteristic ratios of C6-C8 aromatics to i-pentane of vehicular emissions were 0.53 ± 0.08 (benzene), 0.70 ± 0.12 (toluene), 0.41 ± 0.09 (m,p-xylenes), 0.16 ± 0.04 (o-xylene), 0.023 ± 0.011 (styrene), and 0.15 ± 0.02 (ethylbenzene), respectively. The source apportionment results showed that around 23.3% of C6-C8 aromatics in urban Shanghai were from vehicular emissions, which meant that the non-vehicular emissions had more importance. These findings suggested that emission control of non-vehicular sources, i.e. industrial emissions, should also receive attention in addition to the control of vehicle-related emissions in Shanghai. The chemical removal of VOCs during the transport from emissions to the receptor site had a large impact on the apportionment results. Generally, the overestimation of vehicular contributions would occur when the VOC reaction rate constant with OH radicals (kOH) was larger than that of the vehicular indicator, while for species with smaller kOH than the vehicular indicator, the vehicular contribution would be underestimated by the method of characteristic ratios.

  11. Partnership for the heart. German-Estonian health project for the treatment of congenital heart defects in Estonia.

    Science.gov (United States)

    Köhler, Friedrich; Schierbaum, Clausjürgen; Konertz, Wolfgang; Schneider, Martin; Kern, Hartmut; Int, Eve; Tael, Kristi; Siigur, Urmas; Kleinfeld, Klaus; Bühlmeyer, Konrad; Fotuhi, Parwis; Winter, Stefan Frank

    2005-08-01

    Congenital heart defects (CHD) occur in 8 per 1000 live births. If they remain untreated, 70-80% of these patients die in early childhood. With modern diagnostic and treatment procedures, 90% of these patients reach adulthood. Within 8 years following reunification of Germany, it was possible to improve treatment for CHD in former East Germany to West German standards. Based on the experience gained in this process, a plan for improvement of care of Estonian patients with CHD was developed and implemented in the German-Estonian project, "Partnership for the Heart". The main elements of the project were (1) the training of Estonian physicians in Germany, (2) training courses conducted by German and Estonian specialists in Estonia and (3) use of telemedicine for consultation on a continuous basis. During the project 15 Estonian patients underwent cardiac surgery and/or catheter interventions performed by a joint team of German and Estonian specialists. The infant mortality due to CHD in Estonia fell by 28% during the project period. Key techniques of cardiac surgery are now being employed in Estonia without outside support, indicating the success of the training program and the long-term improvements to cardiac health care in Estonia. The total project costs were 314,252 Euro (euro), which is 50% lower than the estimated cost of treating the 15 patients abroad in Western Europe. The structure of "Partnership for the Heart" and the modified self-sufficiency model of medical care have not only produced results for Estonia but can be taken as a template for future bilateral health projects with other transition countries and for other fields of medical specialisation, and thus might aid a European health policy.

  12. Priorities for mental health research in Europe: A survey among national stakeholders' associations within the ROAMER project.

    Science.gov (United States)

    Fiorillo, Andrea; Luciano, Mario; Del Vecchio, Valeria; Sampogna, Gaia; Obradors-Tarragó, Carla; Maj, Mario

    2013-06-01

    Within the ROAMER project, funded by the European Commission, a survey was conducted with national associations/organizations of psychiatrists, other mental health professionals, users and/or carers, and psychiatric trainees in the 27 countries of the European Union, aiming to explore their views about priorities for mental health research in Europe. One hundred and eight associations/organizations returned the questionnaire. The five most frequently selected research priorities were early detection and management of mental disorders, quality of mental health services, prevention of mental disorders, rehabilitation and social inclusion, and new medications for mental disorders. All these areas, except the last one, were among the top ten research priorities according to all categories of stakeholders, along with stigma and discrimination. These results seem to support the recent argument that some rebalancing in favor of psychosocial and health service studies may be needed in psychiatric research. PMID:23737426

  13. Priorities for mental health research in Europe: A survey among national stakeholders' associations within the ROAMER project

    Science.gov (United States)

    Fiorillo, Andrea; Luciano, Mario; Del Vecchio, Valeria; Sampogna, Gaia; Obradors-Tarragó, Carla; Maj, Mario

    2013-01-01

    Within the ROAMER project, funded by the European Commission, a survey was conducted with national associations/organizations of psychiatrists, other mental health professionals, users and/or carers, and psychiatric trainees in the 27 countries of the European Union, aiming to explore their views about priorities for mental health research in Europe. One hundred and eight associations/organizations returned the questionnaire. The five most frequently selected research priorities were early detection and management of mental disorders, quality of mental health services, prevention of mental disorders, rehabilitation and social inclusion, and new medications for mental disorders. All these areas, except the last one, were among the top ten research priorities according to all categories of stakeholders, along with stigma and discrimination. These results seem to support the recent argument that some rebalancing in favor of psychosocial and health service studies may be needed in psychiatric research. PMID:23737426

  14. Is story-based blended learning a promising avenue for skin and sexual health education? Results from the PAEDIMED project.

    Science.gov (United States)

    Apfelbacher, Christian J; Deimling, Erika; Wulfhorst, Britta; Adler, Frederic; Diepgen, Thomas L; Linder, Dennis; Blenk, Holger; Stosiek, Nikolaus; Reinmann, Gabi

    2010-03-01

    The PAEDIMED study group developed a learning and teaching scenario for school health education in the area of skin and sexual health in Italy, Romania and Germany, combining web-based and traditional learning ("blended learning"). A questionnaire-based needs assessment and context analysis were conducted, based on which an education scenario was designed. Particular emphasis was put on emotional and motivational aspects, using narrative components in the didactic concept. The design process occupied a central role in the project (design-based research). Evaluation was both formative and summative. Continuous feedback was obtained from relevant stakeholders. Following a prototypical implementation, the scenario was evaluated using questionnaires. The results revealed a high level of acceptance of the education scenario as well as an increase in students' knowledge concerning skin and sexual health. Evaluation also suggested that health education is highly influenced by cultural background and habits as well as diverse contextual and personal conditions. PMID:20169298

  15. International programme on the health effects of the Chernobyl accidents (IPHECA). Protocol for the pilot project ''Thyroid''

    International Nuclear Information System (INIS)

    The protocol document for the Thyroid Project of International Programme on the Health Effects of the Chernobyl Accidents (IPHECA) describes the main aims of the project, namely 1) to detect and describe selected diseases of the thyroid among children and adolescents in population centres assigned earlier as ''strictly controlled zones'' and, 2) to determine, if possible, the link between the prevalence of the diseases and radiation doses received by the thyroid. Population to be investigated, medical and laboratory examinations and advanced diagnostics for thyroid diseases to be undertaken are enlisted in the protocol

  16. Preventing socioeconomic inequalities in health behaviour in adolescents in Europe: Background, design and methods of project TEENAGE

    Directory of Open Access Journals (Sweden)

    Faggiano Fabrizio

    2009-05-01

    Full Text Available Abstract Background Higher prevalence rates of unhealthy behaviours among lower socioeconomic groups contribute substantially to socioeconomic inequalities in health in adults. Preventing the development of these inequalities in unhealthy behaviours early in life is an important strategy to tackle socioeconomic inequalities in health. Little is known however, about health promotion strategies particularly effective in lower socioeconomic groups in youth. It is the purpose of project TEENAGE to improve knowledge on the prevention of socioeconomic inequalities in physical activity, diet, smoking and alcohol consumption among adolescents in Europe. This paper describes the background, design and methods to be used in the project. Methods/design Through a systematic literature search, existing interventions aimed at promoting physical activity, a healthy diet, preventing the uptake of smoking or alcohol, and evaluated in the general adolescent population in Europe will be identified. Studies in which indicators of socioeconomic position are included will be reanalysed by socioeconomic position. Results of such stratified analyses will be summarised by type of behaviour, across behaviours by type of intervention (health education, environmental interventions and policies and by setting (individual, household, school, and neighbourhood. In addition, the degree to which effective interventions can be transferred to other European countries will be assessed. Discussion Although it is sometimes assumed that some health promotion strategies may be particularly effective in higher socioeconomic groups, thereby increasing socioeconomic inequalities in health-related behaviour, there is little knowledge about differential effects of health promotion across socioeconomic groups. Synthesizing stratified analyses of a number of interventions conducted in the general adolescent population may offer an efficient guidance for the development of strategies and

  17. Innovation in Health Policy Education: Project-Based Service Learning at a Distance for Graduate Midwifery Students.

    Science.gov (United States)

    Van Hoover, Cheri

    2015-01-01

    Core competencies for midwifery practice include an understanding of systems of health care delivery and advocacy for legislation and policy initiatives that promote quality in health care. Today's rapidly changing health care environment, due in part to the implementation of the Patient Protection and Affordable Care Act, mandates that midwives possess greater literacy in health policy and comfort with political action than ever before. Frequently disinterested in politics and intimidated by the policymaking process, student midwives lack the foundational knowledge and practical skills needed to meet this professional obligation. The Midwifery Institute of Philadelphia University graduate program educates both student nurse-midwives and student midwives in health policy using an innovative, project-based service-learning approach featuring real-world collaborative experiences. This novel teaching style is ideally suited for instruction at a distance because of the diversity of experience brought to the virtual classroom by students in widely disparate geopolitical locations. As students accomplish measurable objectives within their individually developed projects and reflect with classmates about their experiences, they feel empowered to effect change and report lower perceived barriers to future political engagement.

  18. Health system and societal barriers for gestational diabetes mellitus (GDM) services - lessons from World Diabetes Foundation supported GDM projects

    DEFF Research Database (Denmark)

    Nielsen, Karoline Kragelund; de Courten, Maximilian; Kapur, Anil

    2012-01-01

    Background Maternal mortality and morbidity remains high in many low- and middle-income countries (LMIC). Gestational Diabetes Mellitus (GDM) represents an underestimated and unrecognised impediment to optimal maternal health in LMIC; left untreated – it also has severe consequences...... for the offspring. A better understanding of the barriers hindering detection and treatment of GDM is needed. Based on experiences from World Diabetes Foundation (WDF) supported GDM projects this paper seeks to investigate societal and health system barriers to such efforts. Methods Questionnaires were filled out...

  19. Development of a respiratory protection survey instrument for occupational health nurses: an educational project.

    Science.gov (United States)

    Taormina, Deborah; Burgel, Barbara J

    2013-02-01

    The Institute of Medicine (2011) report Occupational Health Nurses and Respiratory Protection: Improving Education and Training outlined seven recommendations to improve the competency of occupational health nurses in respiratory protection. An advisory group was convened in December 2011, with stakeholder representation from the Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health/National Personal Protective Technology Laboratory, American Association of Occupational Health Nurses, Inc., American Board for Occupational Health Nurses, Inc., Association of Occupational Health Professionals in Healthcare, American Nurses Association, and Institute of Medicine Standing Committee on Personal Protective Equipment for Workplace Safety and Health. The initial work of the advisory group included developing and administering a survey to assess current occupational health nurse roles and responsibilities relevant to respiratory protection. Development of the survey was led by a master's student and advisor who worked with the advisory group. The process of tool development and preliminary findings are presented in this article. PMID:23380641

  20. Public-Private Partnerships for Health Promotion: The Experiences of the S[superscript 5] Project

    Science.gov (United States)

    Gold, J.; Hellard, M. E.; Lim, M. S.; Dixon, H.; Wakefield, M.; Aitken, C. K.

    2012-01-01

    There is increasing emphasis on involving the private sector in public health to harness the considerable resources and skills of the business world to address significant health issues. While such collaboration should be encouraged, the involvement of business in public health campaigns can raise unexpected challenges when the approaches and…

  1. Developing a Set of Health Indicators for People with Intellectual Disabilities: "Pomona" Project

    Science.gov (United States)

    Walsh, Patricia Noonan; Linehan, Christine; Kerr, M. P.; van Schrojenstein Lantman-de Valk, H. M. J.; Buono, Serafino; Azema, Bernard; Aussilloux, Charles; Maatta, Tuomo; Salvador-Carulla, Luis; Garrido-Cumbrera, Marco; van Hove, Geert; Bjorkman, Monica; Ceccotto, Raymond; Kamper, Marion; Weber, Germain; Heiss, Cecilia; Haveman, Meindert; Jorgensen, Frank Ulmer; O'Farrell, Lisa

    2005-01-01

    The European Commission's Health Monitoring Programme culminated in the development of a set of European Community Health Indicators (ECHI) for the general population. Despite evidence of marked disparities between the health of people with intellectual disabilities (ID) and their peers in the general population, the ECHI contain no significant…

  2. Chernobyl Studies Project: Working group 7.0, Environmental transport and health effects. Progress report, March--September 1994

    Energy Technology Data Exchange (ETDEWEB)

    Anspaugh, L.R.; Hendrickson, S.M. [eds.

    1994-12-01

    In April 1988, the US and the former-USSR signed a Memorandum of Cooperation (MOC) for Civilian Nuclear Reactor Safety; this MOC was a direct result of the accident at the Chernobyl Nuclear Power Plant Unit 4 and the following efforts by the two countries to implement a joint program to improve the safety of nuclear power plants and to understand the implications of environmental releases. A Joint Coordinating Committee for Civilian Nuclear Reactor Safety (JCCCNRS) was formed to implement the MOC. The JCCCNRS established many working groups; most of these were the responsibility of the Nuclear Regulatory Commission, as far as the US participation was concerned. The lone exception was Working Group 7 on Environmental Transport and Health Effects, for which the US participation was the responsibility of the US Department of Energy (DOE). The purpose of Working Group 7 was succintly stated to be, ``To develop jointly methods to project rapidly the health effects of any future nuclear reactor accident.`` To implement the work DOE then formed two subworking groups: 7.1 to address Environmental Transport and 7.2 to address Health Effects. Thus, the DOE-funded Chernobyl Studies Project began. The majority of the initial tasks for this project are completed or near completion. The focus is now turned to the issue of health effects from the Chernobyl accident. Currently, we are involved in and making progress on the case-control and co-hort studies of thyroid diseases among Belarussian children. Dosimetric aspects are a fundamental part of these studies. We are currently working to implement similar studies in Ukraine. A major part of the effort of these projects is supporting these studies, both by providing methods and applications of dose reconstruction and by providing support and equipment for the medical teams.

  3. The SAPUVETNET Projects: experiences of intersectoral collaboration and research/training in Veterinary Public Health across Latin America and Europe

    OpenAIRE

    De Meneghi, Daniele; Porporato, piercarlo; Cediel, Natalia; Vilhena, Manuela; Padre, Ludovina; Arroube, Sofia; Baltasar, Patrícia; Custodio, Angelo; Villamil, Luis Carlos; de Balogh, Katinka; Estol, Leopold; Sommerfelt, Irma; Vargas, Raul; Hoet, Armando; Gil, Andres

    2011-01-01

    SAPUVETNET is the acronym of “Red de Salud Publica Veterinaria/Network of Veterinary Public Health”, a series of projects co-financed under the EU ALFA program, aimed to support an International network on Veterinary Public Health (VPH) constituted by Faculties of Veterinary Medicine from Latin-America (LA) and Europe (EU) (http://www.sapuvetnet.org). Since its start in 2002, SAPUVETNET has been continuously growing and expanding, and now it also includes several International collaborating...

  4. Interprofessional practice in health care: an educational project with four learning sequences for students from six study programs

    OpenAIRE

    Nowak, Anna Christina; Klimke-Jung, Kathrin; Schäfer, Thorsten; Reif, Karl

    2016-01-01

    Introduction: In response to demographic changes and the growing complexity of healthcare demands, national and international organizations are requiring greater cooperation among the health professions. Implementation of interprofessional learning programs within study programs in medicine, midwifery, nursing, and therapy is still rare. The first projects are currently underway in Germany. This paper presents the experience gathered by the organizers as interprofessional courses for six stud...

  5. Differences in exposure to occupational health risks in Spanish and foreign-born workers in Spain (Itsal Project)

    OpenAIRE

    Ronda Pérez, Elena; Andrés A. Agudelo Suárez; García García, Ana María; López Jacob, María José; Ruiz Frutos, Carlos; García Benavides, Fernando

    2012-01-01

    Migrant workers usually show higher rates of work-related health problems than natives. However, little information is available about their exposure to occupational risks. We describe self-reported working exposure in Spanish and foreign-born workers. A cross-sectional survey was conducted as part of the ITSAL Project. Data on sociodemographic and self-reported occupational exposure in 1,841 foreign-born and 509 Spanish workers were collected through face-to-face interviews. Prevalence and a...

  6. Between flows and therapeutic projects: revisiting the notions of lines of care in health and therapeutic itineraries.

    Science.gov (United States)

    Silva, Neide Emy Kurokawa E; Sancho, Leyla Gomes; Figueiredo, Wagner dos Santos

    2016-03-01

    This essay discusses the possibilities of conceptual and practical connections between the ideas of line of care and therapeutic itineraries, beginning with the theoretical contributions that lay the foundations for the Line of Integrated Healthcare and the hermeneutic approaches to Care. The implementation of lines of care tuned to individual and collective health needs can be glimpsed in the construction of therapeutic projects, inasmuch as they privilege the particularities of each situation in the agreement of flows of appointments, exams, and other procedures. The therapeutic project - taken as an arrangement, strategy, device, or basic dimension of Care in the work process in health - can be seen as an image that lays out a possibility of the future, which in turn is a projection conditioned by past experiences of health, illness, and life. From the criticism of explanatory models, preponderant in the studies of therapeutic itineraries, we defend the investment in approaches that privilege interpretation and understanding, capable of recuperating, contextualizing, and reconstructing trajectories, beginning with the subjects involved in the care process. PMID:26960096

  7. Investigation of the in vitro toxicological properties of the synthetic cannabimimetic drug CP-47,497-C8

    Energy Technology Data Exchange (ETDEWEB)

    Koller, Verena J., E-mail: verena.koller@meduniwien.ac.at [Institute of Cancer Research, Department of Internal Medicine 1, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8A, 1090 Vienna (Austria); Auwärter, Volker, E-mail: volker.auwaerter@uniklinik-freiburg.de [Institute of Forensic Medicine, University Medical Center Freiburg, Albertstraße 9, 79104 Freiburg (Germany); Grummt, Tamara, E-mail: tamara.grummt@uba.de [German Federal Environmental Agency, Heinrich-Heine-Str., 12, 08645 Bad Elster (Germany); Moosmann, Bjoern, E-mail: bjoern.moosmann@uniklinik-freiburg.de [Institute of Forensic Medicine, University Medical Center Freiburg, Albertstraße 9, 79104 Freiburg (Germany); Mišík, Miroslav, E-mail: miroslav.misik@meduniwien.ac.at [Institute of Cancer Research, Department of Internal Medicine 1, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8A, 1090 Vienna (Austria); Knasmüller, Siegfried, E-mail: siegfried.knasmueller@meduniwien.ac.at [Institute of Cancer Research, Department of Internal Medicine 1, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8A, 1090 Vienna (Austria)

    2014-06-01

    Cannabicyclohexanol (CP-47,497-C8) is a representative of a group of cannabimimetic cyclohexylphenols which is added to herbal mixtures as a cannabis substitute since 2008. Although in the beginning CP-47,497-C8 was the main ingredient of “Spice” and similar products, it was partly replaced by aminoalkylindole-type cannabinoid receptor agonists like JWH-018, JWH-073 or JWH-250, but never completely disappeared from the market. Since information on its toxicological properties is scarce, we investigated the effects of the drug in human derived cell lines. The cytotoxic effects were studied in a panel of assays (SRB, XTT, LDHe and NR tests) in a buccal derived (TR146) and a liver derived (HepG2) cell line. The strongest effects were seen in the two former assays at levels ≥ 7.5 μM indicating that the compound interferes with protein synthesis and causes membrane damage. In additional comet assays, DNA damage was detected at levels ≥ 10 μM. Experiments with lesion specific enzymes showed that these effects are not due to oxidative damage of DNA bases. The negative findings obtained in Salmonella/microsome assays and the positive results of micronucleus tests with the cell lines indicate that the compound does not cause gene mutations but acts on the chromosomal level. In contrast to other synthetic cannabinoids, no indication for estrogenic/antiestrogenic properties was seen in a luciferase assay with bone marrow derived U2-OS cells. In conclusion, our findings show that the drug has only weak cytotoxic properties. However, the induction of chromosomal damage indicates that it may cause adverse effects in users due to its impact on the stability of the genetic material. - Highlights: • We tested the toxic properties of a synthetic cannabinoid. • Acute cytotoxic effects were detected with doses ≥ 7 μM. • No hormonal effects were found. • DNA damage was detected at levels ≥ 10 μM in comet assay and micronucleus tests. • Effects in directly

  8. Investigation of the in vitro toxicological properties of the synthetic cannabimimetic drug CP-47,497-C8

    International Nuclear Information System (INIS)

    Cannabicyclohexanol (CP-47,497-C8) is a representative of a group of cannabimimetic cyclohexylphenols which is added to herbal mixtures as a cannabis substitute since 2008. Although in the beginning CP-47,497-C8 was the main ingredient of “Spice” and similar products, it was partly replaced by aminoalkylindole-type cannabinoid receptor agonists like JWH-018, JWH-073 or JWH-250, but never completely disappeared from the market. Since information on its toxicological properties is scarce, we investigated the effects of the drug in human derived cell lines. The cytotoxic effects were studied in a panel of assays (SRB, XTT, LDHe and NR tests) in a buccal derived (TR146) and a liver derived (HepG2) cell line. The strongest effects were seen in the two former assays at levels ≥ 7.5 μM indicating that the compound interferes with protein synthesis and causes membrane damage. In additional comet assays, DNA damage was detected at levels ≥ 10 μM. Experiments with lesion specific enzymes showed that these effects are not due to oxidative damage of DNA bases. The negative findings obtained in Salmonella/microsome assays and the positive results of micronucleus tests with the cell lines indicate that the compound does not cause gene mutations but acts on the chromosomal level. In contrast to other synthetic cannabinoids, no indication for estrogenic/antiestrogenic properties was seen in a luciferase assay with bone marrow derived U2-OS cells. In conclusion, our findings show that the drug has only weak cytotoxic properties. However, the induction of chromosomal damage indicates that it may cause adverse effects in users due to its impact on the stability of the genetic material. - Highlights: • We tested the toxic properties of a synthetic cannabinoid. • Acute cytotoxic effects were detected with doses ≥ 7 μM. • No hormonal effects were found. • DNA damage was detected at levels ≥ 10 μM in comet assay and micronucleus tests. • Effects in directly

  9. Reducing inequalities in health and access to health care in a rural Indian community: an India-Canada collaborative action research project

    Directory of Open Access Journals (Sweden)

    Mohindra KS

    2011-11-01

    unanticipated external forces, maintaining a strong team in the rural village, retaining human resources capable of analyzing the data, and encouraging Paniya participation in the health insurance scheme were challenges. Successes were at least partially enabled by the length of the funding (this was a two-phase project over an eight year period.

  10. Effect of preduodenal lipase inhibition in suckling rats on dietary octanoic acid (C8:0) gastric absorption and plasma octanoylated ghrelin concentration.

    Science.gov (United States)

    Lemarié, F; Cavalier, J-F; Garcia, C; Boissel, F; Point, V; Catheline, D; Legrand, P; Carrière, F; Rioux, V

    2016-09-01

    Part of medium chain fatty acids (MCFAs) coming from dietary triglycerides (TGs) can be directly absorbed through the gastric mucosa after the action of preduodenal lipase (lingual lipase in the rat). MCFA gastric absorption, particularly that of octanoic acid (C8:0), may have a physiological importance in the octanoylation of ghrelin, the orexigenic gastric peptide acting as an endogenous ligand of the hypothalamic growth hormone secretagogue receptor 1a (GHSR-1a). However, the amount of C8:0 absorbed in the stomach and its metabolic fate still haven't been clearly characterized. The purpose of the present study was to further characterize and quantify the importance of preduodenal lipase activity on the release and gastric absorption of dietary C8:0 and on the subsequent ghrelin octanoylation in the stomach mucosa. Fifteen days old rats received fat emulsions containing triolein or [1,1,1-(13)C]-Tri-C8:0 and a specific inhibitor of preduodenal lipase, 5-(2-(benzyloxy)ethoxy)-3-(3-phenoxyphenyl)-1,3,4-oxadiazol-2(3H)-one or BemPPOX. The fate of the (13)C-C8:0 was followed in rat tissues after 30 and 120min of digestion and octanoylated ghrelin was measured in the plasma. This work (1) demonstrates that part of C8:0 coming from Tri-C8:0 is directly absorbed at the gastric level, (2) allows the estimation of C8:0 gastric absorption level (1.3% of the (13)C-C8:0 in sn-3 position after 30min of digestion), as well as (3) the contribution of rat lingual lipase to total lipolysis and to duodenal absorption of dietary FAs (at least 30%), (4) shows no short-term effect of dietary Tri-C8:0 consumption and subsequent increase of C8:0 gastric tissue content on plasma octanoylated ghrelin concentration. PMID:27317984

  11. Access to health services in Western Newfoundland, Canada: Issues, barriers and recommendations emerging from a community-engaged research project

    Directory of Open Access Journals (Sweden)

    Janelle Hippe

    2014-06-01

    Full Text Available Research indicates that people living in rural and remote areas of Canada face challenges to accessing health services. This article reports on a community-engaged research project conducted by investigators at Memorial University of Newfoundland in collaboration with the Rural Secretariat Regional Councils and Regional Partnership Planners for the Corner Brook–Rocky Harbour and Stephenville–Port aux Basques Rural Secretariat Regions of Newfoundland and Labrador. The aim of this research was to gather information on barriers to accessing health services, to identify solutions to health services’ access issues and to inform policy advice to government on enhancing access to health services. Data was collected through: (1 targeted distribution of a survey to communities throughout the region, and (2 informal ‘kitchen table’ discussions to discuss health services’ access issues. A total of 1049 surveys were collected and 10 kitchen table discussions were held. Overall, the main barriers to care listed in the survey included long wait times, services not available in the area and services not available at time required. Other barriers noted by survey respondents included transportation problems, financial concerns, no medical insurance coverage, distance to travel and weather conditions. Some respondents reported poorer access to maternal/child health and breast and cervical screening services and a lack of access to general practitioners, pharmacy services, dentists and nurse practitioners. Recommendations that emerged from this research included improving the recruitment of rural physicians, exploring the use of nurse practitioners, assisting individuals with travel costs,  developing specialist outreach services, increasing use of telehealth services and initiating additional rural and remote health research. Keywords: rural, remote, healthcare, health services, social determinants of health

  12. Motivations, concerns and preferences of personal genome sequencing research participants: Baseline findings from the HealthSeq project.

    Science.gov (United States)

    Sanderson, Saskia C; Linderman, Michael D; Suckiel, Sabrina A; Diaz, George A; Zinberg, Randi E; Ferryman, Kadija; Wasserstein, Melissa; Kasarskis, Andrew; Schadt, Eric E

    2016-01-01

    Whole exome/genome sequencing (WES/WGS) is increasingly offered to ostensibly healthy individuals. Understanding the motivations and concerns of research participants seeking out personal WGS and their preferences regarding return-of-results and data sharing will help optimize protocols for WES/WGS. Baseline interviews including both qualitative and quantitative components were conducted with research participants (n=35) in the HealthSeq project, a longitudinal cohort study of individuals receiving personal WGS results. Data sharing preferences were recorded during informed consent. In the qualitative interview component, the dominant motivations that emerged were obtaining personal disease risk information, satisfying curiosity, contributing to research, self-exploration and interest in ancestry, and the dominant concern was the potential psychological impact of the results. In the quantitative component, 57% endorsed concerns about privacy. Most wanted to receive all personal WGS results (94%) and their raw data (89%); a third (37%) consented to having their data shared to the Database of Genotypes and Phenotypes (dbGaP). Early adopters of personal WGS in the HealthSeq project express a variety of health- and non-health-related motivations. Almost all want all available findings, while also expressing concerns about the psychological impact and privacy of their results. PMID:26036856

  13. Motivations, concerns and preferences of personal genome sequencing research participants: Baseline findings from the HealthSeq project.

    Science.gov (United States)

    Sanderson, Saskia C; Linderman, Michael D; Suckiel, Sabrina A; Diaz, George A; Zinberg, Randi E; Ferryman, Kadija; Wasserstein, Melissa; Kasarskis, Andrew; Schadt, Eric E

    2016-01-01

    Whole exome/genome sequencing (WES/WGS) is increasingly offered to ostensibly healthy individuals. Understanding the motivations and concerns of research participants seeking out personal WGS and their preferences regarding return-of-results and data sharing will help optimize protocols for WES/WGS. Baseline interviews including both qualitative and quantitative components were conducted with research participants (n=35) in the HealthSeq project, a longitudinal cohort study of individuals receiving personal WGS results. Data sharing preferences were recorded during informed consent. In the qualitative interview component, the dominant motivations that emerged were obtaining personal disease risk information, satisfying curiosity, contributing to research, self-exploration and interest in ancestry, and the dominant concern was the potential psychological impact of the results. In the quantitative component, 57% endorsed concerns about privacy. Most wanted to receive all personal WGS results (94%) and their raw data (89%); a third (37%) consented to having their data shared to the Database of Genotypes and Phenotypes (dbGaP). Early adopters of personal WGS in the HealthSeq project express a variety of health- and non-health-related motivations. Almost all want all available findings, while also expressing concerns about the psychological impact and privacy of their results.

  14. Estimated pKa values for the environmentally relevant C1 through C8 perfluorinated sulfonic acid isomers.

    Science.gov (United States)

    Rayne, Sierra; Forest, Kaya

    2016-10-14

    In order to estimate isomer-specific acidity constants (pKa) for the perfluorinated sulfonic acid (PFSA) environmental contaminants, the parameterization method 6 (PM6) pKa prediction method was extensively validated against a wide range of carbon oxyacids and related sulfonic/sulfinic acids. Excellent pKa prediction performance was observed for the carbon oxyacids using the PM6 method, but this approach was found to have a severe positive bias for sulfonic/sulfinic acids. To overcome this obstacle, a correlation was developed between non-adjusted PM6 pKa values and the corresponding experimentally obtained/estimated acidity constants for a range of representative alkyl, aryl and halogen-substituted sulfonic acids. Application of this correction to the PM6 values allows for extension of this computational method to a new acid functional group. When used to estimate isomer-specific pKa values for the C1 through C8 PFSAs, the modified PM6 approach suggests an adjusted pKa range from -5.3 to -9.0, indicating that all members of this class of well-known environmental contaminants will be effectively completely dissociated in aquatic systems. PMID:27389973

  15. Assessment of the feasibility of studying the potential health effects of the West Valley Solidification Project. Phase II

    International Nuclear Information System (INIS)

    The activities at West Valley involve potential exposure to ionizing radiation. The health effects from radiation are well known and the projected levels of exposure in this situation are so low as to pose no known health hazard in the community. In such a situation it is not reasonable to propose an expensive, comprehensive and physically invasive screening program for the public unless one could justify the benefits. This report describes a feasible population-based surveillance or disease monitoring system which could be implemented in the West Valley area in order to assess the relevance of any changes in incidence of disease which might be attributable to radiation. The proposed plan is both practical and inexpensive. It would anticipate any potential changes in the health status of the population and provide a means to objectively interpret such changes before major concerns develop

  16. A near miss: the importance of context in a public health informatics project in a New Zealand case study.

    Science.gov (United States)

    Wells, Stewart; Bullen, Chris

    2008-01-01

    This article describes the near failure of an information technology (IT) system designed to support a government-funded, primary care-based hepatitis B screening program in New Zealand. Qualitative methods were used to collect data and construct an explanatory model. Multiple incorrect assumptions were made about participants, primary care workflows and IT capacity, software vendor user knowledge, and the health IT infrastructure. Political factors delayed system development and it was implemented untested, almost failing. An intensive rescue strategy included system modifications, relaxation of data validity rules, close engagement with software vendors, and provision of intensive on-site user support. This case study demonstrates that consideration of the social, political, technological, and health care contexts is important for successful implementation of public health informatics projects. PMID:18579835

  17. An Interdisciplinary Educational Project in Comprehensive Family Health Care. Final Report.

    Science.gov (United States)

    Tanner, Libby A.

    To develop skills and understanding of interdisciplinary teamwork, the University of Miami's Department of Family Medicine and the School of Nursing conducted a project involving 10 teams of medical, nursing, and social work students. The primary objectives of the project were: (1) to instill and maintain positive attitudes in student physicians,…

  18. Advanced Structural Health Monitoring System for Comprehensive Real-Time Vehicle Characterization Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In providing an innovative solution to improving information technologies and health management systems, AGNC is proposing a significant technological achievement...

  19. Flexible High Energy-Conversion Sensing Materials for Structural Health Monitoring Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The applicant is developing flexible highly-efficient piezoelectric materials for use in structural health monitoring (SHM) as contemplated in the solicitation...

  20. Highly Reliable Structural Health Monitoring of Smart Composite Vanes for Jet Engine Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In Phase 1, Intelligent Fiber Optic Systems (IFOS) successfully demonstrated a Fiber Bragg Grating (FBG) based integrated Structural Health Monitoring (SHM) sensor...

  1. Coalition Building for Health: A Community Garden Pilot Project with Apartment Dwelling Refugees.

    Science.gov (United States)

    Eggert, Lynne K; Blood-Siegfried, Jane; Champagne, Mary; Al-Jumaily, Maha; Biederman, Donna J

    2015-01-01

    Refugees often experience compromised health from both pre- and post-migration stressors. Coalition theory has helped guide the development of targeted programs to address the health care needs of vulnerable populations. Using the Community Coalition Action Theory as a framework, a coalition was formed to implement a community garden with apartment-dwelling refugees. Outcomes included successful coalition formation, a community garden, reported satisfaction from all gardeners with increased vegetable intake, access to culturally meaningful foods, and evidence of increased community engagement. The opportunity for community health nurses to convene a coalition to affect positive health for refugees is demonstrated. PMID:26212466

  2. Highly Reliable Structural Health Monitoring of Smart Composite Vanes for Jet Engine Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Intelligent Fiber Optic Systems and Auburn University propose a Fiber Bragg Grating (FBG) integrated Structural Health Monitoring (SHM) sensor system capable of...

  3. Structural Health Monitoring with Fiber Bragg Grating and Piezo Arrays Project

    Data.gov (United States)

    National Aeronautics and Space Administration — IFOS and its research institute collaborator, Washington State University (WSU), have demonstrated feasibility of a structural health monitoring (SHM) system for...

  4. Projections of 21st Century African Climate: Implications for African Savanna Fire Dynamics, Human Health and Food Security

    Science.gov (United States)

    Adegoke, J. O.

    2015-12-01

    Fire is a key agent of change in the African savannas, which are shaped through the complex interactions between trees, C4 grasses, rainfall, temperature, CO2 and fire. These fires and their emitted smoke can have numerous direct and indirect effects on the environment, water resources, air quality, and climate. For instance, veld fires in southern Africa cause large financial losses to agriculture, livestock production and forestry on an annual basis. This study contributes to our understanding of the implications of projected surface temperature evolution in Africa for fire risk, human health and agriculture over the coming decades. We use an ensemble of high-resolution regional climate model simulations of African climate for the 21st century. Regional dowscalings and recent global circulation model projections obtained for Africa indicate that African temperatures are likely to rise at 1.5 times the global rate of temperature increase in the tropics, and at almost twice the global rate of increase in the subtropics. Warming is projected to occur during the 21st century, with increases of 4-6 °C over the subtropics and 3-5 °C over the tropics plausible by the end of the century relative to present-day climate under the A2 (low mitigation) scenario. We explore the significance of the projected warming by documenting increases in projected high fire danger days and heat-wave days. General drying is projected across the continent, even for areas (e.g. tropical Africa) where an increase in rainfall is plausible. This is due to the drastic increases in temperature that are projected, which leads to drier soils (through enhanced evaporation) despite the rainfall increases. This will likely impact negatively on crop yield, particularly on the maize crop that is of crucial importance in terms of African food security.

  5. An exercise-based randomized controlled trial on brain, cognition, physical health and mental health in overweight/obese children (ActiveBrains project): Rationale, design and methods.

    Science.gov (United States)

    Cadenas-Sánchez, Cristina; Mora-González, José; Migueles, Jairo H; Martín-Matillas, Miguel; Gómez-Vida, José; Escolano-Margarit, María Victoria; Maldonado, José; Enriquez, Gala María; Pastor-Villaescusa, Belén; de Teresa, Carlos; Navarrete, Socorro; Lozano, Rosa María; de Dios Beas-Jiménez, Juan; Estévez-López, Fernando; Mena-Molina, Alejandra; Heras, María José; Chillón, Palma; Campoy, Cristina; Muñoz-Hernández, Victoria; Martínez-Ávila, Wendy Daniela; Merchan, María Elisa; Perales, José C; Gil, Ángel; Verdejo-García, Antonio; Aguilera, Concepción M; Ruiz, Jonatan R; Labayen, Idoia; Catena, Andrés; Ortega, Francisco B

    2016-03-01

    The new and recent advances in neuroelectric and neuroimaging technologies provide a new era for further exploring and understanding how brain and cognition function can be stimulated by environmental factors, such as exercise, and particularly to study whether physical exercise influences brain development in early ages. The present study, namely the ActiveBrains project, aims to examine the effects of a physical exercise programme on brain and cognition, as well as on selected physical and mental health outcomes in overweight/obese children. A total of 100 participants aged 8 to 11 years are randomized into an exercise group (N=50) or a control group (N=50). The intervention lasts 20-weeks, with 3-5 sessions per week of 90 min each, and is mainly focused on high-intensity aerobic exercise yet also includes muscle-strengthening exercises. The extent to what the intervention effect remains 8-months after the exercise programme finishes is also studied in a subsample. Brain structure and function and cognitive performance are assessed using structural and functional magnetic resonance imaging and electroencephalographic recordings. Secondary outcomes include physical health outcomes (e.g. physical fitness, body fatness, bone mass and lipid-metabolic factors) and mental health outcomes (e.g. chronic stress indicators and overall behavioural and personality measurements such as anxiety or depression). This project will substantially contribute to the existing knowledge and will have an impact on societies, since early stimulation of brain development might have long lasting consequences on cognitive performance, academic achievement and in the prevention of behavioural problems and the promotion of psychological adjustment and mental health. Clinical trials. Gov identifier: NCT02295072. PMID:26924671

  6. Impact of community-based maternal health workers on coverage of essential maternal health interventions among internally displaced communities in eastern Burma: the MOM project.

    Directory of Open Access Journals (Sweden)

    Luke C Mullany

    Full Text Available BACKGROUND: Access to essential maternal and reproductive health care is poor throughout Burma, but is particularly lacking among internally displaced communities in the eastern border regions. In such settings, innovative strategies for accessing vulnerable populations and delivering basic public health interventions are urgently needed. METHODS: Four ethnic health organizations from the Shan, Mon, Karen, and Karenni regions collaborated on a pilot project between 2005 and 2008 to examine the feasibility of an innovative three-tiered network of community-based providers for delivery of maternal health interventions in the complex emergency setting of eastern Burma. Two-stage cluster-sampling surveys among ever-married women of reproductive age (15-45 y conducted before and after program implementation enabled evaluation of changes in coverage of essential antenatal care interventions, attendance at birth by those trained to manage complications, postnatal care, and family planning services. RESULTS: Among 2,889 and 2,442 women of reproductive age in 2006 and 2008, respectively, population characteristics (age, marital status, ethnic distribution, literacy were similar. Compared to baseline, women whose most recent pregnancy occurred during the implementation period were substantially more likely to receive antenatal care (71.8% versus 39.3%, prevalence rate ratio [PRR] = 1.83 [95% confidence interval (CI 1.64-2.04] and specific interventions such as urine testing (42.4% versus 15.7%, PRR = 2.69 [95% CI 2.69-3.54], malaria screening (55.9% versus 21.9%, PRR = 2.88 [95% CI 2.15-3.85], and deworming (58.2% versus 4.1%, PRR = 14.18 [95% CI 10.76-18.71]. Postnatal care visits within 7 d doubled. Use of modern methods to avoid pregnancy increased from 23.9% to 45.0% (PRR = 1.88 [95% CI 1.63-2.17], and unmet need for contraception was reduced from 61.7% to 40.5%, a relative reduction of 35% (95% CI 28%-40%. Attendance at birth by those trained to

  7. 75 FR 51083 - Office of Clinical and Preventive Services Maternal and Child Health Program: Project Choices...

    Science.gov (United States)

    2010-08-18

    ... HUMAN SERVICES Indian Health Service Office of Clinical and Preventive Services Maternal and Child...) Morbidity and Mortality Weekly Report (MMWR) dated May 2009 cites studies showing that 0.2 to 1.5 cases of... programmatic involvement will be provided under this CA. The IHS Maternal and Child Health (MCH) Coordinator...

  8. Estimates and Projections of Black and Hispanic Personnel in Selected Health Professions, 1980-2000.

    Science.gov (United States)

    Spratley, Ernell

    Federal efforts to establish financial support for health professions education in the 1960s and 1970s have led to an increase in the enrollment of minorities and women in health professions schools. The increase in the number of minority students graduating from these schools during the past decade has resulted in more minority practitioners…

  9. Assessing opinions in community leadership networks to address health inequalities: a case study from Project IMPACT.

    Science.gov (United States)

    McCauley, M P; Ramanadhan, S; Viswanath, K

    2015-12-01

    This study demonstrates a novel approach that those engaged in promoting social change in health can use to analyze community power, mobilize it and enhance community capacity to reduce health inequalities. We used community reconnaissance methods to select and interview 33 participants from six leadership sectors in 'Milltown', the New England city where the study was conducted. We used UCINET network analysis software to assess the structure of local leadership and NVivo qualitative software to analyze leaders' views on public health and health inequalities. Our main analyses showed that community power is distributed unequally in Milltown, with our network of 33 divided into an older, largely male and more powerful group, and a younger, largely female group with many 'grassroots' sector leaders who focus on reducing health inequalities. Ancillary network analyses showed that grassroots leaders comprise a self-referential cluster that could benefit from greater affiliation with leaders from other sectors and identified leaders who may serve as leverage points in our overall program of public agenda change to address health inequalities. Our innovative approach provides public health practitioners with a method for assessing community leaders' views, understanding subgroup divides and mobilizing leaders who may be helpful in reducing health inequalities. PMID:26471919

  10. Promoting Health Behaviors Using Peer Education: A Demonstration Project between International and American College Students

    Science.gov (United States)

    Yan, Zi; Finn, Kevin; Cardinal, Bradley J.; Bent, Lauren

    2014-01-01

    Background: Peer education has the potential to promote health behaviors and cultural competence for both international and domestic college students. Purpose: The present study examined a peer education program aimed at promoting cultural competence and health behaviors among international and American students in a university setting. Methods:…

  11. Educational health inequalities in former Yugoslavia : evidence from the South-East European Social Survey Project

    NARCIS (Netherlands)

    Eikemo, Terje Andreas; Huisman, Martijn; Perlman, Francesca; Ringdal, Kristen

    2010-01-01

    Background: An important gap in our knowledge of social inequalities in health is the former Yugoslavia, a region of culturally and historically diverse countries, with recent conflict. The aim of the present paper is to investigate relative and absolute inequalities in self-assessed health in forme

  12. 17beta-estradiol attenuates hyperoxia-induced apoptosis in mouse C8-D1A cell line.

    Science.gov (United States)

    Huppmann, Stephanie; Römer, Susanne; Altmann, Rodica; Obladen, Michael; Berns, Monika

    2008-11-15

    In premature infants, oxygen free radicals generated following neonatal resuscitation are associated with subsequent diseases such as retinopathy of prematurity and bronchopulmonary dysplasia. Recent studies in brain tissue samples have shown that nonphysiologic oxygen levels play a key role in induction of apoptosis in the developing brain. Estrogen is a well-established agent in neuroprotection and, therefore, is thought to be neuroprotective even in the premature brain. Astrocytes appear to have a critical role in protection and survival of neurons in the brain. As one of the glial cell types, they have a great potential for possible involvement in the mediation of estrogen neuroprotective effects. The aim of our study was to analyze whether astrocytes in cell cultures are damaged by hyperoxia and whether 17beta-estradiol (E2) can protect them against apoptosis. Additionally, we investigated the mechanism of the protection by E2, hypothesizing that it is mediated through extracellular signal-regulated kinase (ERK1/2). Cells underwent eightfold more apoptosis when cultivated in hyperoxia compared with normoxia. Addition of E2 reduced apoptosis in hyperoxia by more than 50%. Levels of ERK1/2 and phosphorylated ERK1/2 were increased after hyperoxia compared with normoxia. Preincubation with E2 prior to exposure to hyperoxia resulted in decreased levels of ERK1/2 and pERK1/2. Hyperoxia induces apoptosis in C8-D1A cells, and E2 seems to be a protecting factor for astrocytes in hyperoxia. This effect is not mediated through up-regulation of pERK1/2.

  13. VUV and soft x-ray ionization of a plant volatile: Vanillin (C8H8O3)

    Science.gov (United States)

    Betancourt, A. Moreno; Coutinho, L. H.; Bernini, R. B.; de Moura, C. E. V.; Rocha, A. B.; de Souza, G. G. B.

    2016-03-01

    Plant volatiles are emitted by plants in response to several forms of stress, including interaction with energetic photons. In the present work, we discuss the interaction of extreme UV and soft X-ray photons with a plant volatile, vanillin. The single and double (multiple) ionization of the vanillin molecule have been studied for the first time using time-of-flight mass spectrometry and VUV and soft X-ray photons (synchrotron radiation, at 12.0 eV, 21.2 eV, 130 eV, 310 eV, 531 eV, and 550 eV). At 12.0 and 21.2 eV, only singly charged species are observed and the parent ion, C8H8O3+, is the dominant species. Energy differences for some selected fragments were calculated theoretically in this energy region. At 130 eV, direct double and triple ionization of the valence electrons may occur. The fragmentation increases and CHO+ becomes one of the main cations in the mass spectrum. The molecular ion is still the dominant species, but other fragments, such as C6H5O+, begin to present similar intensities. At 310 eV, C 1s electrons may be ionized and Auger processes give rise to dissociative doubly ionized cations. Ionization around the O 1s edge has been studied both at the 531 eV resonance and above the ionization edge. Resonant and normal Auger processes play a significant role in each case and a large fragmentation of the molecule is observed at both photon energies, with intense fragments such as CHO+ and CH3+ being clearly observed. A near edge X-ray absorption fine structure spectrum of the vanillin molecule was obtained around the O 1s ionization threshold. In addition, the fragmentation of vanillin has also been studied using a fast beam of electrons (800 eV), for the sake of comparison.

  14. VUV and soft x-ray ionization of a plant volatile: Vanillin (C8H8O3).

    Science.gov (United States)

    Betancourt, A Moreno; Coutinho, L H; Bernini, R B; de Moura, C E V; Rocha, A B; de Souza, G G B

    2016-03-21

    Plant volatiles are emitted by plants in response to several forms of stress, including interaction with energetic photons. In the present work, we discuss the interaction of extreme UV and soft X-ray photons with a plant volatile, vanillin. The single and double (multiple) ionization of the vanillin molecule have been studied for the first time using time-of-flight mass spectrometry and VUV and soft X-ray photons (synchrotron radiation, at 12.0 eV, 21.2 eV, 130 eV, 310 eV, 531 eV, and 550 eV). At 12.0 and 21.2 eV, only singly charged species are observed and the parent ion, C8H8O3 (+), is the dominant species. Energy differences for some selected fragments were calculated theoretically in this energy region. At 130 eV, direct double and triple ionization of the valence electrons may occur. The fragmentation increases and CHO(+) becomes one of the main cations in the mass spectrum. The molecular ion is still the dominant species, but other fragments, such as C6H5O(+), begin to present similar intensities. At 310 eV, C 1s electrons may be ionized and Auger processes give rise to dissociative doubly ionized cations. Ionization around the O 1s edge has been studied both at the 531 eV resonance and above the ionization edge. Resonant and normal Auger processes play a significant role in each case and a large fragmentation of the molecule is observed at both photon energies, with intense fragments such as CHO(+) and CH3 (+) being clearly observed. A near edge X-ray absorption fine structure spectrum of the vanillin molecule was obtained around the O 1s ionization threshold. In addition, the fragmentation of vanillin has also been studied using a fast beam of electrons (800 eV), for the sake of comparison.

  15. Project monitoring and evaluation: an enhancing method for health research system management

    Directory of Open Access Journals (Sweden)

    Shirin Djalalinia

    2014-01-01

    Conclusions: We concluded that; although monitoring and evaluation as an essential part of HRS Management light the improvement ahead way but we still need to advantage of the new project management advances.

  16. Self-Repairing Flight Control System for Online Health Monitoring and Recovery Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this SBIR project, a reliable self-repairing Flight Control System (FCS) will be developed. To achieve this goal, an artificial Neural Network based Sensor...

  17. Outcome of a Community-Based Oral Health Promotion Project on Primary Schoolchildren’s Oral Hygiene Habits

    Directory of Open Access Journals (Sweden)

    Heidi Halonen

    2013-01-01

    Full Text Available The aim of this study was to evaluate the effect of a school-based intervention project conducted in a mid-sized Finnish city, Laukaa on schoolchildren’s oral health behavior. Material and Methods. In the intervention, all children received dental education and some of the 7–12-year-old schoolchildren received individual tooth brushing instructions by a dental nurse in 2009-2010. Parents were present at the instruction sessions. In 2009 and 2010, all the children answered a questionnaire or an oral hygienist on their oral health behavior without identification. Results. Tooth brushing frequency increased significantly among the schoolchildren between the years 2009 (61.2% and 2010 (65% (; more so among younger children (7–10-year-olds compared to the older ones (11-12-year-olds. The 2010 results showed a slight trend of decreasing tooth brushing frequency by age both among girls and boys. Younger children got significantly more often parental help or reminding. The girls brushed their teeth significantly more frequently (71.9% than boys (57.0%. Conclusions. Our findings indicate that oral health intervention can be beneficial on health behavior especially for children at low grades. All children, 11 to 12 years of age, especially boys, need continuous health promotion.

  18. Educating clinicians on new elements incorporated into the electronic health record: theories, evidence, and one educational project.

    Science.gov (United States)

    Topaz, Maxim; Rao, Aditi; Masterson Creber, Ruth; Bowles, Kathryn H

    2013-08-01

    With the widespread use of health information technologies, there is a growing need to educate healthcare providers on the use of technological innovations. Appropriate health information technology education is critical to ensure quality documentation, patient privacy, and safe healthcare. One promising strategy for educating clinicians is the use of participatory e-learning based on the principles of Web 2.0. However, there is a lack of literature on the practical applications of this training strategy in clinical settings. In this article, we briefly review the theoretical background and published literature on distance education, or e-learning, of health information technology, focusing on electronic health records. Next, we describe one example of a theoretically grounded interactive educational intervention that was implemented to educate nurses on new elements incorporated into the existing electronic health record system. We discuss organizational factors facilitating nurses' in-service education and provide an example of software designed to create interactive e-learning presentations. We also evaluate the results of our educational project and make suggestions for future applications. In conclusion, we suggest four core principles that should guide the construction and implementation of distant education for healthcare practitioners.

  19. Interprofessional practice in health care: an educational project with four learning sequences for students from six study programs

    Directory of Open Access Journals (Sweden)

    Nowak, Anna Christina

    2016-04-01

    Full Text Available Introduction: In response to demographic changes and the growing complexity of healthcare demands, national and international organizations are requiring greater cooperation among the health professions. Implementation of interprofessional learning programs within study programs in medicine, midwifery, nursing, and therapy is still rare. The first projects are currently underway in Germany. This paper presents the experience gathered by the organizers as interprofessional courses for six study programs were implemented.Project description: As part of the collaborative project “Interprofessional Practice in Health Care” between the Medical School at the Ruhr University in Bochum and the Department for Applied Health Sciences at the Hochschule für Gesundheit, interprofessional curricular units were developed, taught and evaluated with the aim of establishing permanent and joint curricular structures at the two German universities. Imparting communication skills, knowledge of and appreciation for the work performed by the other health professions, as well as having students reflect on their own professional roles and responsibilities, were the focus of four curricular units. Students worked together in small interprofessional groups.Results: A total of 220 students enrolled in occupational therapy, midwifery, speech therapy, medicine, nursing, and physiotherapy participated in small-group seminars. When conducting and implementing the seminars, administrative and methodological challenges became apparent, and this should be taken into consideration in regard to any future development of interprofessional courses. Integration into existing curricula, along with finding time in the various schedules and appropriate classroom space for small groups, were among the challenges faced. For over 86% of the students it was important that students from all six of the degree programs involved participated in the project. A detailed analysis of the

  20. [Performance assessment of health services in Catalonia (Spain): evaluation of initial results of the Catalan healthcare service project].

    Science.gov (United States)

    García-Altés, Anna; Dalmau-Bueno, Albert; Colls, Cristina; Mendivil, Joan; Benet, Josep; Mompart, Anna; Torné, Elvira; Zara, Corinne; Borrell, Carme; Brugulat, Pilar; Guarga, Alex

    2009-01-01

    Performance assessment of healthcare services is receiving greater attention due to increasing health care expenditures, greater expectations among the population, and the need to obtain results from the invested resources. Taking advantage of the existing experience of the Agència de Salut Pública de Barcelona and the Consorci Sanitari de Barcelona, which compared the healthcare services of Barcelona and Montreal, a grant from the Agència d'Avaluació de Tecnologia i Recerca Mèdiques, and the health planning interest of the Departament de Salut, the performance assessment of the Catalan healthcare service project was started in Catalonia in 2005. This article aims to present the development of the project, to provide some examples that illustrate the kind of numerical and graphical information that could be obtained and the kind of analysis that could be performed, to provide possible explanations for the results shown, and to discuss some limitations and implications. Currently, the added value of this project is that it identifies the extent to which the healthcare system is achieving its objectives, establishes a set of homogeneous indicators that could be used in the future, and is a key tool in the development of the Central de Resultats del Departament de Salut de la Generalitat de Catalunya.

  1. Research in progress: FY 1984. Summaries of projects sponsored by the Office of Health and Environmental Research

    International Nuclear Information System (INIS)

    This report provides a compilation of summaries of the research projects supported by the Office of Health and Environmental Research (OHER) during Fiscal Year 1984. OHER is a component of the Office of Energy Research within the US Department of Energy, responsible for developing a comprehensive understanding of the health and environmental effects of energy technology development and use as well as other Departmental operations. The OHER program is broad in scope and diverse in character with substantial commitments to both applied and basic research. The research projects have been organized to reflect the major themes and focus of the OHER program. Each research category is preceeded by a short narrative to provide some perspective of the scope of activities which follow. Within each research category, the summaries are organized by efforts performed in DOE laboratories (onsite laboratories) and those performed elsewhere (offsite contractors) to help characterize their respective role in the program. The compilation of project titles and summaries, despite its volume, is still a relatively superficial source of information. It does not provide a sound basis for considering program quality or even relevance

  2. Challenges in Developing Health Promoting Schools’ Project: Application of Global Traits in Local Realm

    Directory of Open Access Journals (Sweden)

    Behrouz Fathi

    2014-07-01

    Full Text Available Background: Despite the importance of student health and school hygiene as an aspect of the infrastructure of community health, few feasibility studies have been conducted on school health programs in developing countries. This study examined possible barriers to and challenges of such programs from the executive perspective in East Azerbaijan Province in Iran. Methods: This qualitative study used the content analysis approach to recognize barriers to and challenges of health promoting school program from the executive perspective. Fourteen experts were selected in the areas of children and adolescents and school health, physical education and school headmasters. Data were collected using semi-structured interviews and analyzed using the content analysis method. Results: Five themes were extracted as major barriers and challenges: 1. Intraand inter-sectorial collaboration; 2. Policy and rule formulation; 3. Infrastructure and capacity; 4. Human resources; 5. Community involvement. Conclusion: The localized version of the current health promoting school program had major faults. If this program is considered to be a healthcare system priority, it should be revised to set effective policies for implementation and to sustain school health programs based on the capacities and objectives of each country.

  3. Health diplomacy the adaptation of global health interventions to local needs in sub-Saharan Africa and Thailand: Evaluating findings from Project Accept (HPTN 043

    Directory of Open Access Journals (Sweden)

    Kevany Sebastian

    2012-06-01

    Full Text Available Abstract Background Study-based global health interventions, especially those that are conducted on an international or multi-site basis, frequently require site-specific adaptations in order to (1 respond to socio-cultural differences in risk determinants, (2 to make interventions more relevant to target population needs, and (3 in recognition of ‘global health diplomacy' issues. We report on the adaptations development, approval and implementation process from the Project Accept voluntary counseling and testing, community mobilization and post-test support services intervention. Methods We reviewed all relevant documentation collected during the study intervention period (e.g. monthly progress reports; bi-annual steering committee presentations and conducted a series of semi-structured interviews with project directors and between 12 and 23 field staff at each study site in South Africa, Zimbabwe, Thailand and Tanzania during 2009. Respondents were asked to describe (1 the adaptations development and approval process and (2 the most successful site-specific adaptations from the perspective of facilitating intervention implementation. Results Across sites, proposed adaptations were identified by field staff and submitted to project directors for review on a formally planned basis. The cross-site intervention sub-committee then ensured fidelity to the study protocol before approval. Successfully-implemented adaptations included: intervention delivery adaptations (e.g. development of tailored counseling messages for immigrant labour groups in South Africa political, environmental and infrastructural adaptations (e.g. use of local community centers as VCT venues in Zimbabwe; religious adaptations (e.g. dividing clients by gender in Muslim areas of Tanzania; economic adaptations (e.g. co-provision of income generating skills classes in Zimbabwe; epidemiological adaptations (e.g. provision of ‘youth-friendly’ services in South Africa, Zimbabwe

  4. Challenges of scaling up and of knowledge transfer in an action research project in Burkina Faso to exempt the worst-off from health care user fees

    OpenAIRE

    Kadio Kadidiatou; Kafando Yamba; Yaogo Maurice; Ridde Valéry; Ouedraogo Moctar; Sanfo Marou; Coulibaly Norbert; Bicaba Abel; Haddad Slim

    2011-01-01

    Abstract Background Systems to exempt the indigent from user fees have been put in place to prevent the worst-off from being excluded from health care services for lack of funds. Yet the implementation of these mechanisms is as rare as the operational research on this topic. This article analyzes an action research project aimed at finding an appropriate solution to make health care accessible to the indigent in a rural district of Burkina Faso. Research This action research project was initi...

  5. Augmented Fish Health Monitoring for Washington Department of Wildlife; Five-year Project Report, 1986-1991 Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Kerwin, John; Roberts, Steve; Oman, Leni; Bolding, Bruce

    1992-04-01

    The Augmented Fish Health Monitoring Project was funded by the Bonneville Power Administration (BPA) with the mandate to collect fish health data on the anadromous fish stocks of the Columbia River Basin in a standardized manner. The Washington Department of Wildlife began the project in 1986. Cumulative data and a final summary for this project are presented in this document. Fish stocks were examined monthly for length, weight, and health status at all Washington Department of Wildlife Columbia River Basin hatcheries. Assays for specific fish pathogens were conducted on all stocks of broodfish and smolts in the study area. Pathogens of interest were replicating viral agents, erythrocytic inclusion body syndrome virus (EIBSV), and Renibacterium salmoninarum. Sea-run cutthroat (SCT) were also sampled midway through the rearing cycle for R. salmoninarum. Juvenile fish were examined for the presence of any pathogen. Assays for Myxobolus cerebralis were conducted on fish stocks in several locations along the Columbia River. An organosomatic index analysis was made on each stock of smolts at the Cowlitz and Wells hatcheries. Results of the organosomatic index analysis were consistent between the years at each facility. However, the fish reared at Cowlitz displayed tissue changes associated with ceratomyxosis while those reared at Wells had a more desirable color and quality. Cell culture assays for viral agents in broodfish were positive for infectious hematopoeitic necrosis virus (IHNV) in all stocks at the Cowlitz Hatchery four out of five years in the study. Other stations were less consistent over the years. Only the sea-run cutthroat stock spawned at Beaver Creek was negative for any virus. Infectious pancreatic necrosis virus (IPNV) was isolated from summer-run steelhead (SS) broodfish at Wells in 1989 and 1991 and at Yakima in 1991. Inclusions that are characteristic of EIBSV were found in red blood cells of brood fish from the Wells Hatchery in 1990 and 1991

  6. Business models for cost effective use of health information technologies: lessons learned in the CHCS II project.

    Science.gov (United States)

    Riley, David L

    2003-01-01

    The Department of Defense (DoD) has embarked on an initiative to create an electronic medical record for all of its eligible beneficiaries. The Clinical Information Technology Program Office (CITPO) is the joint-service program office established to centrally manage this multi-year project. The Composite Health Care System II (CHCS II) is the name of the system under development. Given the historical failure rate of large-scale government information system projects, CITPO has employed an incremental acquisition approach and striven to use industry best practices to the greatest degree possible within the constraints of federal acquisition law. Based on lessons learned during the concept exploration phase of this project, CITPO, in partnership with Integic Corporation, the prime integration contractor, has reengineered its software acquisition process to include industry best practices. The result of this reengineering process has resulted in a reduction of the total projected life cycle costs for CHCS II from the original estimate of $7.6 billion over a 14-year period to between $3.9 and $4.3 billion. PMID:15455852

  7. Lightweight, Wearable Metal Rubber-Textile Sensor for In Situ Lunar Autonomous Health Monitoring Project

    Data.gov (United States)

    National Aeronautics and Space Administration — NanoSonic proposes to develop a low-weight, non-invasive in situ autonomous health-monitoring system for crewmembers' lunar extravehicular activity (EVA). This...

  8. Space Qualified Non-Destructive Evaluation and Structural Health Monitoring Technology Project

    Data.gov (United States)

    National Aeronautics and Space Administration — NextGen Aeronautics is proposing an innovative space qualified non-destructive evaluation and health monitoring technology. The technology is built on concepts...

  9. Understanding and Mitigating Adverse Health Effects in Space Using A System Physiology Software Project

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA's vision for Space Exploration aims for human interplanetary missions that have significant challenges on crew health and safety including fluid shifts, and...

  10. Tunable Laser Development for In-flight OFDR Structural Health Monitoring Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Development of a cost-effective, robust, tunable, miniaturized, ruggedized, and flight tested swept laser for in-flight structural health monitoring. The objective...

  11. Reusable Handheld Electrolytes and Lab Technology for Humans (rHEALTH Sensor) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The goal of the rHEALTH sensor is to provide rapid, low-cost, handheld complete blood count (CBC), cell differential counts, electrolyte measurements, and other lab...

  12. Autonomus I&C Maintenance and Health Monitoring System for Fission Surface Power Project

    Data.gov (United States)

    National Aeronautics and Space Administration — There currently exists no end-to-end reactor/power conversion monitoring system that can provide both autonomous health monitoring, but also in-situ sensor...

  13. 78 FR 14072 - Trestle Forest Health Project, Eldorado National Forest, El Dorado County, CA

    Science.gov (United States)

    2013-03-04

    .... Activities would include construction of firelines by hand or tractor, and hand cutting ladder fuels around... proposed action, or take no action to improve forest health. Scoping Process This notice of...

  14. Onboard Space Autonomy Through Integration of Health Management and Control Reconfiguration Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The main objective of this Phase II effort is to develop integrated health management and control reconfiguration algorithms that allow future space systems to...

  15. Reusable Handheld Electrolytes and Lab Technology for Humans (rHEALTH Sensor) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The goal of rHEALTH sensor is a universal handheld sensor that can provide rapid, low-cost complete blood count (CBC) with differential, electrolyte analysis, and...

  16. National Institute of Occupational Safety and Health (NIOSH) Partnered Development of Cryogenic Life Support Technologies Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Partnering with National Institute of Occupational Safety and Health (NIOSH) to develop several cryogenically based life support technologies to be used in mine...

  17. Current issues in the design of academic health sciences libraries: findings from three recent facility projects.

    Science.gov (United States)

    Nelson, Patricia P

    2003-07-01

    Planning a new health sciences library at the beginning of the twenty-first century is a tremendous challenge. Technology has radically changed the way libraries function in an academic environment and the services they provide. Some individuals question whether the library as place will continue to exist as information becomes increasingly available electronically. To understand how libraries resolve programming and building design issues, visits were made to three academic health sciences libraries that have had significant renovation or completed new construction. The information gathered will be valuable for planning a new library for the University of Colorado Health Sciences Center and may assist other health sciences librarians as they plan future library buildings.

  18. Time Reversal Acoustic Structural Health Monitoring Using Array of Embedded Sensors Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Time Reversal Acoustic (TRA) structural health monitoring with an embedded sensor array represents a new approach to in-situ nondestructive evaluation of air-space...

  19. The use of a mobile assistant learning system for health education based on project-based learning.

    Science.gov (United States)

    Wu, Ting-Ting

    2014-10-01

    With the development of mobile devices and wireless technology, mobile technology has gradually infiltrated nursing practice courses to facilitate instruction. Mobile devices save manpower and reduce errors while enhancing nursing students' professional knowledge and skills. To achieve teaching objectives and address the drawbacks of traditional education, this study presents a mobile assistant learning system to help nursing students prepare health education materials. The proposed system is based on a project-based learning strategy to assist nursing students with internalizing professional knowledge and developing critical thinking skills. Experimental results show that the proposed mobile system and project-based learning strategy can promote learning effectiveness and efficiency. Most nursing students and nursing educators showed positive attitudes toward this mobile learning system and looked forward to using it again in related courses in the future. PMID:25140444

  20. Crystal and molecular structure of Bis[π-(cyclobutenocyclooctatetraene)]uranium(IV), U[C8H6(CH2)2]21

    International Nuclear Information System (INIS)

    Crystals of bis[π-(bicyclo[6.2.0]deca-1,3,5,7-tetraene)]uranium(IV), U[C8H6(CH2)2]2, are monoclinic: space group P21/n, a = 9.906 (8) A, b = 11.039 (9) A, c = 7.221 (6) A, β = 98.89 (5)0, V = 780.15 A3, Z = 2, and D/sub x/ = 2.122 g cm-3 at 220C. X-ray diffraction data were measured with counter methods and Mo Kα radiation. With anisotropic temperature factors for the uranium and carbon atoms and isotropic temperature factors for the hydrogen atoms, R = 0.020 for 1315 independent reflections (I > 3 sigma). The molecule is a sandwich compound with the C8 rings in an eclipsed configuration about the uranium atom which is on a center of symmetry. The average U-C distance is 2.64 +- 0.02 A, and the average C-C distance in the C8 ring is 1.39 +- 0.01 A (uncorrected for thermal motion). The cyclobuteno ring is planar and at an angle of 6.80 to the plane of the C8 ring. The C-C bond length is 1.47 (2) A in the -CH2-CH2- moiety, and it is 1.55 (2) A where this group is fused to the C8 ring

  1. Influence and mechanism of N-(3-oxooxtanoyl)-L-homoserine lactone (C8-oxo-HSL) on biofilm behaviors at early stage.

    Science.gov (United States)

    Xia, Siqing; Zhou, Lijie; Zhang, Zhiqiang; Li, Jixiang

    2012-01-01

    N-acyl-homoserines quenching, enzymatic quenching of bacterial quorum sensing, has recently applied to mitigate biofilm in membrane bioreactor. However, the effect of AHLs on the behavior of biofilm formation is still sparse. In this study, Pseudomonas aeruginosa biofilm was formed on ultra-filtration membrane under a series of N-(3-oxooxtanoyl)-L-homoserine lactone (Cs-oxo-HSL) concentrations. Diffusing C8-oxo-HSL increased the growth rate of cells on biofilm where the concentration of C8-oxo-HSL was over 10(-7) g/L. The C8-oxo-HSL gradient had no observable influence on cell density and extracellular polymeric substances of biofilm with over 10(-7) g/L C8-oxo-HSL. Surprisingly, 10(-11)-10(-8) g/L of C8-oxo-HSL had no effect on cell growth in liquid culture. The cell analysis demonstrated that the quorum sensing system might enhance the growth of neighboring cells in contact with surfaces into biofilm and may influence the structure and organization of biofilm.

  2. Student public commitment in a school-based diabetes prevention project: impact on physical health and health behavior

    Directory of Open Access Journals (Sweden)

    Solomon Sara

    2011-09-01

    Full Text Available Abstract Background As concern about youth obesity continues to mount, there is increasing consideration of widespread policy changes to support improved nutritional and enhanced physical activity offerings in schools. A critical element in the success of such programs may be to involve students as spokespeople for the program. Making such a public commitment to healthy lifestyle program targets (improved nutrition and enhanced physical activity may potentiate healthy behavior changes among such students and provide a model for their peers. This paper examines whether student's "public commitment"--voluntary participation as a peer communicator or in student-generated media opportunities--in a school-based intervention to prevent diabetes and reduce obesity predicted improved study outcomes including reduced obesity and improved health behaviors. Methods Secondary analysis of data from a 3-year randomized controlled trial conducted in 42 middle schools examining the impact of a multi-component school-based program on body mass index (BMI and student health behaviors. A total of 4603 students were assessed at the beginning of sixth grade and the end of eighth grade. Process evaluation data were collected throughout the course of the intervention. All analyses were adjusted for students' baseline values. For this paper, the students in the schools randomized to receive the intervention were further divided into two groups: those who participated in public commitment activities and those who did not. Students from comparable schools randomized to the assessment condition constituted the control group. Results We found a lower percentage of obesity (greater than or equal to the 95th percentile for BMI at the end of the study among the group participating in public commitment activities compared to the control group (21.5% vs. 26.6%, p = 0.02. The difference in obesity rates at the end of the study was even greater among the subgroup of students who

  3. [The role of science in policy making--EuSANH-ISA project, framework for science advice for health].

    Science.gov (United States)

    Cianciara, Dorota; Piotrowicz, Maria; Bielska-Lasota, Magdalena; Wysocki, Mirosław J

    2012-01-01

    Governments and other authorities (including MPs) should be well informed on issues of science and technology. This is particularly important in the era of evidence-based practice. This implies the need to get expert advice. The process by which scientific knowledge is transmitted, along with proposals how to solve the problem, is called science advice. The main aim of the article is to discuss the issue of science advice--definitions, interaction between science and policymaking, and its position in contemporary policies. The second aim is to present European Science Advisory Network for Health (EuSANH), EuSANH-ISA project, and framework for science advice for health which was developed by participants. Furthermore, the role of civil society in decision-making process and science advice is also discussed. Interaction between scientists and policy-makers are described in terms of science-push approach (technocratic model), policy-pull (decisionistic) and simultaneous push-pull approach (pragmatic). The position of science advice is described in historical perspective from the 50s, especially in the last two decades. Description relies to USA, Canada and UK. Principles of scientific advice to government (Government Office for Science, UK) are quoted. Some important documents related to science advice in EU and UN are mentioned. EuSANH network is described as well as EuSANH-ISA project, with its objectives and outcomes. According to findings of this project, the process of science advice for health should follow some steps: framing the issue to be covered; planning entire process leading to the conclusion; drafting the report; reviewing the report and revision; publishing report and assessing the impact on policy.

  4. Good practices and health policy analysis in European sports stadia: results from the 'Healthy Stadia' project.

    Science.gov (United States)

    Drygas, Wojciech; Ruszkowska, Joanna; Philpott, Matthew; Björkström, Olav; Parker, Mike; Ireland, Robin; Roncarolo, Federico; Tenconi, Maria

    2013-06-01

    Sport plays an important role within society and sports stadia provide significant settings for public health strategies. In addition to being places of mass gathering, stadia are often located in less affluent areas and are traditionally attended by 'harder to reach' communities. Unfortunately sports stadia and the clubs they host are rarely perceived as places that promote healthy lifestyles. Fast food, alcohol and tobacco are commonly advertized, served and consumed during sports games giving the spectators and TV fans contradictory messages concerning healthy choices. As part of a wider programme of work part-funded by the European Union, a study was therefore designed to explore current 'good practice' relating to positive health interventions in sports stadia across a number of European countries. Using a specially designed questionnaire, information about health policies and good practices relating to food offerings in stadia, physical activity promotion among local communities, tobacco policy, positive mental health initiatives, environmental sustainability practices and social responsibility policies were collected in 10 European countries (England and Northern Ireland, Finland, Georgia, Greece, Ireland, Italy, Latvia, Poland, Spain and Sweden) involving 88 stadia. The audit results show that stadia health policies differ considerably between specific countries and sports. Based on the literature analysed, the examples of good practices collected through the study, and the subsequent instigation of a European Healthy Stadia Network, it shows that there is considerable potential for stadia to become health promoting settings. PMID:22139638

  5. A new AMPHORA: an introduction to the project Alcohol Measures for Public Health Research Alliance.

    Science.gov (United States)

    Gual, Antoni; Anderson, Peter

    2011-03-01

    The AMPHORA Project is a 4 years project funded by the 7th Framework Programme of the European Commission which aims to contribute with new evidence on scarcely explored or unexplored areas of alcohol consumption and alcohol-related harm in Europe. In this introductory article we describe the background of the Project and its main features. The research areas covered by AMPHORA are wide and diverse. Some of the most relevant are: an update on European epidemiological data; the definition of standard common indicators of alcohol consumption and harm; the measurement of the strength of alcohol policies; the study of contextual determinants of alcohol consumption, the analysis of the impact of marketing on youth; the availability of treatments at a European level; and two areas of harm reduction (contamination of illegal or surrogate alcohols and the reduction of harm in drinking venues). PMID:21324015

  6. Health improvement of domestic hot tap water supply Gusev, Kaliningrad Region, Russia. Make-up water tank project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Aagaard, Joergen

    1998-07-01

    This report describes the project `Health Improvement of Domestic Hot Tap Water Supply, Gusev, Kaliningrad, Russia`, which was carried out in the autumn of 1996 and financed by the Danish Environmental Protection Agency, the Danish Energy Agency and Gusev Municipality. The project proposal and application outlined the following objectives: Erection of system so that hot tap water, which is tapped directly from the district heating system, obtains an acceptable quality in health terms; Complete training and education, so that the plant can be operated and maintained by the power station`s staff and rehabilitation projects within supply of domestic water and district heating can be promoted to the greatest possible extent; Systems for heat treatment of make-up water were implemented in less than three months; The project was carried out in close Danish-Russian co-operation from the beginning of engineering to the commissioning and resulted in transfer and demonstration of know-how and technology; Information was recorded on the existing domestic water and heat supply systems as well as on the treatment of sewage, and recommendations for rehabilitation projects were made. Previously, when the temperature in the district heating system was relatively high, a heat treatment apparently took place in the district heating system. However, due to the current poor economic situation there are no means with which to buy the fuel quantities necessary to maintain the previously normal district heating temperature. In the new concept the cold make-up water is heated to >80 deg. C as required by the health authorities before it is led to the district heating return system and subsequently heated to the actual supply temperature of 50-60 deg. C. The energy consumption in the two concepts is approximately the same. A 1,000 m{sup 3} tank with heating coils was erected between the make-up water system and the district heating system. The tank should equalise the daily capacity

  7. Health Promotion and Diabetes Prevention in American Indian and Alaska Native Communities--Traditional Foods Project, 2008-2014.

    Science.gov (United States)

    Satterfield, Dawn; DeBruyn, Lemyra; Santos, Marjorie; Alonso, Larry; Frank, Melinda

    2016-02-12

    Type 2 diabetes was probably uncommon in American Indian and Alaska Native (AI/AN) populations before the 1940s. During 2010-2012, AI/AN adults were approximately 2.1 times as likely to have diabetes diagnosed as non-Hispanic white adults. Although type 2 diabetes in youth is still uncommon, AI/AN youth (aged 15-19 years) experienced a 68% increase in diagnosed diabetes from 1994 to 2004. Health disparities are related to biological, environmental, sociological, and historical factors. This report highlights observations from the Traditional Foods Project (2008-2014) that illustrate tribally driven solutions, built on traditional ecological knowledge, to reclaim foods systems for health promotion and prevention of chronic illnesses, including diabetes. PMID:26916637

  8. Screening Assessment of Potential Human-Health Risk from Future Natural-Gas Drilling Near Project Rulison in Western Colorado

    International Nuclear Information System (INIS)

    The Project Rulison underground nuclear test was conducted in 1969 at a depth of 8,400 ft in the Williams Fork Formation of the Piceance Basin, west-central Colorado (Figure 1). The U.S. Department of Energy Office of Legacy Management (LM) is the steward of the site. Their management is guided by data collected from past site investigations and current monitoring, and by the results of calculations of expected behavior of contaminants remaining in the deep subsurface. The purpose of this screening risk assessment is to evaluate possible health risks from current and future exposure to Rulison contaminants so the information can be factored into LM's stewardship decisions. For example, these risk assessment results can inform decisions regarding institutional controls at the site and appropriate monitoring of nearby natural-gas extraction activities. Specifically, the screening risk analysis can provide guidance for setting appropriate action levels for contaminant monitoring to ensure protection of human health.

  9. Screening Assessment of Potential Human-Health Risk from Future Natural-Gas Drilling Near Project Rulison in Western Colorado

    Energy Technology Data Exchange (ETDEWEB)

    Daniels Jeffrey I.,Chapman Jenny B.

    2012-01-01

    The Project Rulison underground nuclear test was conducted in 1969 at a depth of 8,400 ft in the Williams Fork Formation of the Piceance Basin, west-central Colorado (Figure 1). The U.S. Department of Energy Office of Legacy Management (LM) is the steward of the site. Their management is guided by data collected from past site investigations and current monitoring, and by the results of calculations of expected behavior of contaminants remaining in the deep subsurface. The purpose of this screening risk assessment is to evaluate possible health risks from current and future exposure to Rulison contaminants so the information can be factored into LM's stewardship decisions. For example, these risk assessment results can inform decisions regarding institutional controls at the site and appropriate monitoring of nearby natural-gas extraction activities. Specifically, the screening risk analysis can provide guidance for setting appropriate action levels for contaminant monitoring to ensure protection of human health.

  10. Prognostics and health management (PHM) for astronauts: a collaboration project on the International Space Station

    Science.gov (United States)

    Popov, Alexandre; Fink, Wolfgang; Hess, Andrew

    2016-05-01

    Long-duration missions bring numerous risks that must be understood and mitigated in order to keep astronauts healthy, rather than treat a diagnosed health disorder. Having a limited medical support from mission control center on space exploration missions, crew members need a personal health-tracking tool to predict and assess his/her health risks if no preventive measures are taken. This paper refines a concept employing technologies from Prognostics and Health Management (PHM) for systems, namely real-time health monitoring and condition-based health maintenance with predictive diagnostics capabilities. Mapping particular PHM-based solutions to some Human Health and Performance (HH&P) technology candidates, namely by NASA designation, the Autonomous Medical Decision technology and the Integrated Biomedical Informatics technology, this conceptual paper emphasize key points that make the concept different from that of both current conventional medicine and telemedicine including space medicine. The primary benefit of the technologies development for the HH&P domain is the ability to successfully achieve affordable human space missions to Low Earth Orbit (LEO) and beyond. Space missions on the International Space Station (ISS) program directly contribute to the knowledge base and advancements in the HH&P domain, thanks to continued operations on the ISS, a unique human-tended test platform and the only test bed within the space environment. The concept is to be validated on the ISS, the only "test bed" on which to prepare for future manned exploration missions. The paper authors believe that early self-diagnostic coupled with autonomous identification of proper preventive responses on negative trends are critical in order to keep astronauts healthy.

  11. Research-policy partnerships - experiences of the Mental Health and Poverty Project in Ghana, South Africa, Uganda and Zambia

    Directory of Open Access Journals (Sweden)

    Mirzoev Tolib N

    2012-09-01

    Full Text Available Abstract Background Partnerships are increasingly common in conducting research. However, there is little published evidence about processes in research-policy partnerships in different contexts. This paper contributes to filling this gap by analysing experiences of research-policy partnerships between Ministries of Health and research organisations for the implementation of the Mental Health and Poverty Project in Ghana, South Africa, Uganda and Zambia. Methods A conceptual framework for understanding and assessing research-policy partnerships was developed and guided this study. The data collection methods for this qualitative study included semi-structured interviews with Ministry of Health Partners (MOHPs and Research Partners (RPs in each country. Results The term partnership was perceived by the partners as a collaboration involving mutually-agreed goals and objectives. The principles of trust, openness, equality and mutual respect were identified as constituting the core of partnerships. The MOHPs and RPs had clearly defined roles, with the MOHPs largely providing political support and RPs leading the research agenda. Different influences affected partnerships. At the individual level, personal relationships and ability to compromise within partnerships were seen as important. At the organisational level, the main influences included the degree of formalisation of roles and responsibilities and the internal structures and procedures affecting decision-making. At the contextual level, political environment and the degree of health system decentralisation affected partnerships. Conclusions Several lessons can be learned from these experiences. Taking account of influences on the partnership at individual, organisation and contextual/system levels can increase its effectiveness. A common understanding of mutually-agreed goals and objectives of the partnership is essential. It is important to give attention to the processes of initiating and

  12. Primary care physician's attitude towards the German e-health card project--determinants and implications.

    Science.gov (United States)

    Ernstmann, Nicole; Ommen, Oliver; Neumann, Melanie; Hammer, Antje; Voltz, Raymond; Pfaff, Holger

    2009-06-01

    In Germany e-health cards will be distributed nationwide to over 80 million patients. Given the impending mandatory introduction of the e-health technology, the objective of this study was to examine the determinants of primary care physicians' acceptance of the technological innovation. The study was conducted prior to the introduction of the e-health cards. A questionnaire survey was carried out addressing primary care physicians from different fields. The reduction of medication error rates and the improvement of communication between medical caregivers are central aspects of the perceived usefulness. Primary care physicians rate their involvement in the process of the development of the technology and their own IT expertise concerning the technological innovation as rather low. User involvement and IT expertise can explain 46 % of the variance of perceived usefulness of the e-health card. User involvement plays a crucial role in the adoption of the German e-health card. Primary care physician's perspective should be represented in the process of developing and designing the technology. PMID:19408451

  13. 75 FR 8927 - Autism Services Demonstration Project for TRICARE Beneficiaries Under the Extended Care Health...

    Science.gov (United States)

    2010-02-26

    ... Notice in the Federal Register (FR) (72 FR 68130) of a TRICARE demonstration to increase access to IBI... of the Secretary Autism Services Demonstration Project for TRICARE Beneficiaries Under the Extended...: This notice provides a 2-year extension of the Department of Defense Enhanced Access to Autism...

  14. 78 FR 2947 - Manti-La Sal National Forest, Utah; Maverick Point Forest Health Project

    Science.gov (United States)

    2013-01-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE... waste rock. The project is also designed to provide for a sustainable and manageable system of roads and... ages, structures, and species (both herbaceous and woody) to buffer against large-scale fire,...

  15. The IDEAS Project: evaluating complexity in maternal and newborn health in Ethiopia, Nigeria and India

    OpenAIRE

    Schellenberg, JA

    2013-01-01

    A presentation given by Project Principal Investigator Professor Joanna Schellenberg to the School's Centre for Evaluation. Outline •Background, motivation •Objectives, research questions •Selected methods and results •Technical Resource Centre •Who we are •Highlights and challenges

  16. Current public health perspective of fluorosis mitigation project in Pavagada taluk, Karnataka

    Directory of Open Access Journals (Sweden)

    Halappa Mythri

    2012-01-01

    Full Text Available Background: Fluoride has become a recurring theme in discussing water issues in India. In Karnataka, where groundwater sources are concentrated with fluorides the impact is devastating. Dental and spine-related ailments are showing up in many cities and villages. Several villages in Pavagada taluk in Tumkur district have fluoride concentration 5 times more than the permissible level. The different aspects to the problem are many defluoridation interventions were failure. Objective: To determine and compare fluoride level in water samples from Fluorosis mitigation project area. Materials and Methods: Samples of municipal water were collected in sterile containers in an unannounced visit. All the samples of water were assigned a code so that those undertaking analysis would be blind to the source. Fluoride levels were determined by an ion-selective electrode (Orion 94-09 method. Results: Mean fluoride level in the water samples collected in the project was 0.8 which was within the normal range. Conclusion: Even though the fluoride level was within the normal limits after implementation of flourosis mitigation project, ground reality was numbers of beneficiaries were less. Hence, proper planning and monitoring always becomes essential for any project to be successful.

  17. Safe sanitation: Findings from the impact evaluation baseline survey in Thiruvarur, Tamil Nadu, India ; Financial Inclusion Improves Sanitation and Health - FINISH Project

    OpenAIRE

    Augsburg, Britta

    2011-01-01

    FINISH - Financial Inclusion Improves Sanitation and Health - is a joint undertaking of a wide range of actors that came together to address the challenges of micro finance, insurance and sanitation and health. The overall goal of the project itself is to built 1 million safe toilets (possibly sanitation systems), financed through microfinance loans.

  18. DNA polymerases κ and ζ cooperatively perform mutagenic translesion synthesis of the C8-2'-deoxyguanosine adduct of the dietary mutagen IQ in human cells.

    Science.gov (United States)

    Bose, Arindam; Pande, Paritosh; Jasti, Vijay P; Millsap, Amy D; Hawkins, Edward K; Rizzo, Carmelo J; Basu, Ashis K

    2015-09-30

    The roles of translesion synthesis (TLS) DNA polymerases in bypassing the C8-2'-deoxyguanosine adduct (dG-C8-IQ) formed by 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), a highly mutagenic and carcinogenic heterocyclic amine found in cooked meats, were investigated. Three plasmid vectors containing the dG-C8-IQ adduct at the G1-, G2- or G3-positions of the NarI site (5'-G1G2CG3CC-3') were replicated in HEK293T cells. Fifty percent of the progeny from the G3 construct were mutants, largely G→T, compared to 18% and 24% from the G1 and G2 constructs, respectively. Mutation frequency (MF) of dG-C8-IQ was reduced by 38-67% upon siRNA knockdown of pol κ, whereas it was increased by 10-24% in pol η knockdown cells. When pol κ and pol ζ were simultaneously knocked down, MF of the G1 and G3 constructs was reduced from 18% and 50%, respectively, to <3%, whereas it was reduced from 24% to <1% in the G2 construct. In vitro TLS using yeast pol ζ showed that it can extend G3*:A pair more efficiently than G3*:C pair, but it is inefficient at nucleotide incorporation opposite dG-C8-IQ. We conclude that pol κ and pol ζ cooperatively carry out the majority of the error-prone TLS of dG-C8-IQ, whereas pol η is involved primarily in its error-free bypass. PMID:26220181

  19. The role of technology in reducing health care costs. Final project report

    Energy Technology Data Exchange (ETDEWEB)

    Sill, A.E.; Warren, S.; Dillinger, J.D.; Cloer, B.K.

    1997-08-01

    Sandia National Laboratories applied a systems approach to identifying innovative biomedical technologies with the potential to reduce U.S. health care delivery costs while maintaining care quality. This study was conducted by implementing both top-down and bottom-up strategies. The top-down approach used prosperity gaming methodology to identify future health care delivery needs. This effort provided roadmaps for the development and integration of technology to meet perceived care delivery requirements. The bottom-up approach identified and ranked interventional therapies employed in existing care delivery systems for a host of health-related conditions. Economic analysis formed the basis for development of care pathway interaction models for two of the most pervasive, chronic disease/disability conditions: coronary artery disease (CAD) and benign prostatic hypertrophy (BPH). Societal cost-benefit relationships based on these analyses were used to evaluate the effect of emerging technology in these treatment areas. 17 figs., 48 tabs.

  20. High resolution LT-STM imaging of PTCDA molecules assembled on an InSb(001) c(8 x 2) surface

    International Nuclear Information System (INIS)

    The self-assembling of 3,4,9,10-perylene-tetracarboxylic-dianhydride (PTCDA) molecules deposited on an InSb(001) c(8 x 2) surface at sub-monolayer quantities has been investigated at low temperature (77 K) using scanning tunnelling microscopy. Sub-molecular resolution was obtained on PTCDA molecules. The results reveal that individual PTCDA molecules are arranged on the substrate in chains parallel to the [110] crystallographic direction, correlated with characteristic features of the low temperature InSb(001) c(8 x 2) surface electronic structure. A structural model for PTCDA molecules adsorbed on InSb is proposed

  1. Implementation of self-rostering (the PRIO-project) Effects on working hours, recovery and health

    DEFF Research Database (Denmark)

    Garde, Anne Helene; Albertsen, Karen; Nabe Nielsen, Kirsten;

    2012-01-01

    .17, 95% CI -0.29– -0.04) and B (β= -0.17, 95% CI -0.27– -0.07). There were no effects on recovery and health in intervention C, and overall, there were no detrimental effects on recovery or health. The benefits of the intervention were not related to changes in working hours and did not differ by gender......, age, family type, degree of employment, or working hour arrangements. Conclusions After implementation of self-rostering, employees changed shift length and timing but did not compromise most recommendations for acceptable shift work schedules. Positive consequences of self-rostering for recovery...

  2. Alzheimer's Project

    Medline Plus

    Full Text Available ... voluntary health organization in Alzheimer's care, support and research, the Alzheimer's Association has been an active partner in "THE ALZHEIMER'S PROJECT," ... (48 minutes) "Momentum ...

  3. The process of minimising medicine use through dialogue based animal health and welfare planning, Workshop report FIBL. In: CORE Organic project no. 1903 - ANIPLAN

    OpenAIRE

    Alfoeldi, Thomas; Gantner, Urs; Vaarst, Mette; Algers, Bo; Nicholas, Phillipa; Gratzer, Elisabeth; Henriksen, Britt I. F.; Mejdell, Cecilie; Hansen, Berit; Whay, Becky; Walkenhorst, Michael; Smolders, Gidi; Ivemeyer, Silvia; Hassing, M.; Roderick, Stephen

    2011-01-01

    The process of minimising medicine use through dialogue based animal health and welfare planning. Livestock are important in many organic farming systems, and it is an explicit goal to ensure high levels of animal health and welfare (AHW) through good management. In two previous EU network projects, NAHWOA & SAFO, it was concluded that this is not guaranteed merely by following organic standards. Both networks recommended implementation of individual animal health plans to stimulate organ...

  4. “Making a difference” – Medical students’ opportunities for transformational change in health care and learning through quality improvement projects

    OpenAIRE

    Bergh, Anne-Marie; Bac, Martin; Hugo, Jannie; Sandars, John

    2016-01-01

    Background Quality improvement is increasingly becoming an essential aspect of the medical curriculum, with the intention of improving the health care system to provide better health care. The aim of this study was to explore undergraduate medical students’ experiences of their involvement in quality improvement projects during a district health rotation. Methods Student group reports from rotations in learning centres of the University of Pretoria in Mpumalanga Province, South Africa were an...

  5. The Los Angeles County Community Disaster Resilience Project — A Community-Level, Public Health Initiative to Build Community Disaster Resilience

    OpenAIRE

    David Eisenman; Anita Chandra; Stella Fogleman; Aizita Magana; Astrid Hendricks; Ken Wells; Malcolm Williams; Jennifer Tang; Alonzo Plough

    2014-01-01

    Public health officials need evidence-based methods for improving community disaster resilience and strategies for measuring results. This methods paper describes how one public health department is addressing this problem. This paper provides a detailed description of the theoretical rationale, intervention design and novel evaluation of the Los Angeles County Community Disaster Resilience Project (LACCDR), a public health program for increasing community disaster resilience. The LACCDR Proj...

  6. Study protocol for the World Health Organization project to develop a Quality of Life assessment instrument (WHOQOL).

    Science.gov (United States)

    1993-04-01

    The World Health Organization (WHO) has undertaken a project to develop an instrument (the WHOQOL) for measuring quality of life. Quality of life is defined as an individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns. It is a broad ranging concept affected in a complex way by the person's physical health, psychological state, level of independence, social relationships, and their relationship to salient features of their environment. The instrument will be developed in the framework of a collaborative project involving numerous centres in different cultural settings. In addition, it will have proven psychometric properties of validity, responsiveness and reliability and will be sensitive to the cultural setting in which it is applied, whilst maintaining comparability of scores across different cultural settings. This paper outlines the characteristics of the planned instrument and the study protocol governing work on its development. To date steps 1 through 5 have been completed and work is progressing on step 6. It is anticipated that the instrument will be available for piloting in July 1993 and a final version available for use in June 1994. PMID:8518769

  7. Legal Requirements for Human-Health based appeals of Wind Energy Projects in Ontario

    Directory of Open Access Journals (Sweden)

    Albert Michael Engel

    2014-12-01

    Full Text Available In 2009 the government of the province of Ontario, Canada passed new legislation to promote the development of renewable energy facilities, including wind energy facilities in the province. Throughout the legislative process, concerns were raised with respect to the effect of wind energy facilities on human health. Ultimately, the government established setbacks and sound level limits for wind energy facilities and provided Ontario residents with the right to appeal the approval of a wind energy facility on the ground that engaging in the facility in accordance with its approval will cause serious harm to human health. The first approval of a wind facility under the new legislation was issued in 2010 and since then, Ontario’s Environmental Review Tribunal as well as Ontario’s courts have been considering evidence proffered by appellants seeking revocation of approvals on the basis of serious harm to human health. To date, the evidence has been insufficient to support the revocation of a wind facility approval. This article reviews the legal basis for the dismissal of human-health based appeals.

  8. Educational health inequalities in former Yugoslavia: Evidence from the South-East European social survey project

    NARCIS (Netherlands)

    T.A. Eikemo (Terje); M. Huisman (Martijn); F. Perlman (Francesca); K. Ringdal (Kristen)

    2010-01-01

    textabstractBackground: An important gap in our knowledge of social inequalities in health is the former Yugoslavia, a region of culturally and historically diverse countries, with recent conflict. The aim of the present paper is to investigate relative and absolute inequalities in self-assessed hea

  9. Perinatal health monitoring in Europe: results from the EURO-PERISTAT project.

    Science.gov (United States)

    Gissler, Mika; Mohangoo, Ashna D; Blondel, Beatrice; Chalmers, Jim; Macfarlane, Alison; Gaizauskiene, Aldona; Gatt, Miriam; Lack, Nicholas; Sakkeus, Luule; Zeitlin, Jennifer

    2010-03-01

    Data about deliveries, births, mothers and newborn babies are collected extensively to monitor the health and care of mothers and babies during pregnancy, delivery and the post-partum period, but there is no common approach in Europe. We analysed the problems related to using the European data for international comparisons of perinatal health. We made an inventory of relevant data sources in 25 European Union (EU) member states and Norway, and collected perinatal data using a previously defined indicator list. The main sources were civil registration based on birth and death certificates, medical birth registers, hospital discharge systems, congenital anomaly registers, confidential enquiries and audits. A few countries provided data from routine perinatal surveys or from aggregated data collection systems. The main methodological problems were related to differences in registration criteria and definitions, coverage of data collection, problems in combining information from different sources, missing data and random variation for rare events. Collection of European perinatal health information is feasible, but the national health information systems need improvements to fill gaps. To improve international comparisons, stillbirth definitions should be standardised and a short list of causes of fetal and infant deaths should be developed. PMID:20726736

  10. Performance estimation of networked business models : Case study on a Finnish eHealth Service Project

    NARCIS (Netherlands)

    Heikkilä, M.; Solaimani, H. (Sam); Kuivaniemi, L.; Suoranta, M.

    2014-01-01

    Purpose: The objective of this paper is to propose and demonstrate a framework for estimating performance in a networked business model. Design/methodology/approach: Our approach is design science, utilising action research in studying a case of four independent firms in Health & Wellbeing sector ai

  11. CORE health project: production and use of environmental radioactivity measurement data and internal contamination data for the health status follow-up of children in Belarus

    International Nuclear Information System (INIS)

    Large regions in Belarus remain contaminated particularly with 137Cs at such a level that it has to be taken into account on day-to-day life. Hundreds of thousands inhabitants live in these territories. Their concerns are mainly focused on child health problems, and they lack of means to evaluate radioactivity in their environment to better manage it. IRSN has initiated a programme in the Chechersk district (Belarus) to improve information about child sanitary status; this project is developed in collaboration with two NGOs, ACRO and Medecins du Monde, which will be respectively in charge of improving radiological quality, pregnancy follow-ups and actions with the population in order to identify their expectations. (authors)

  12. National Health Expenditure Data

    Data.gov (United States)

    U.S. Department of Health & Human Services — National Health Expenditure Accounts are comprised of the following, National Health Expenditures - Historical and Projected, Age Estimates, State Health...

  13. Synthesis and antibacterial activity of sulfonamide derivatives at C-8 alkyl chain of anacardic acid mixture isolated from a natural product cashew nut shell liquid (CNSL)

    Indian Academy of Sciences (India)

    N Subhakara Reddy; A Srinivas Rao; M Adharvana Chari; V Ravi Kumar; V Jyothy; V Himabindu

    2012-05-01

    Synthesis and antibacterial activity of some novel biologically active sulfonamide derivatives at C-8 alkyl chain of anacardic acid (7a-7l), prepared from commercially available anacardic acid mixture (1a-d). These compounds were tested for Gram positive and Gram negative bacterial cultures; most of the compounds showed higher antibacterial activity compared with standard drug ampicillin.

  14. C8-Selective Acylation of Quinoline N-Oxides with α-Oxocarboxylic Acids via Palladium-Catalyzed Regioselective C-H Bond Activation.

    Science.gov (United States)

    Chen, Xiaopei; Cui, Xiuling; Wu, Yangjie

    2016-08-01

    A facile and efficient protocol for palladium-catalyzed C8-selective acylation of quinoline N-oxides with α-oxocarboxylic acids has been developed. In this approach, N-oxide was utilized as a stepping stone for the remote C-H functionalization. The reactions proceeded efficiently under mild reaction conditions with excellent regioselectivity and broad functional group tolerance. PMID:27441527

  15. Diastereoselective dihydroxylation and regioselective deoxygenation of dihydropyranones: a novel protocol for the stereoselective synthesis of C1-C8 and C15-C21 subunits of (+)-discodermolide.

    Science.gov (United States)

    Ramachandran, P Veeraraghavan; Prabhudas, Bodhuri; Chandra, J Subash; Reddy, M Venkat Ram

    2004-09-17

    Diastereoselective dihydroxylation of dihydropyranones and subsequent regioselective alpha-deoxygenation provides 1,3-trans-beta-hydroxy-delta-lactones stereoselectively. This protocol has been applied for the synthesis of C(1)-C(8) and C(15)-C(21) subunits of (+)-discodermolide.

  16. Nearly Perfect Spin Filter Based on a Wire of Half-Metallic (η5-C5H5)Ti (η8-C8H8)Ti Units

    Science.gov (United States)

    Zhu, Sicong; Fang, Jianming; Yao, Kailun; Wu, Yanqing

    2015-07-01

    Organic molecular devices show strong potential for future nanoelectronics applications, many of which require multifunction capability. Organometallic [(C5H5)Ti(C8H8)] n clusters are one of the few molecular material clusters that have been synthesized experimentally. Here we present a theoretical study of the spin-polarized transport on the clusters of [(C5H5)Ti(C8H8)] n by using nonequilibrium Green's functions combined with the density-functional theory. Results indicate that one-dimensional, organic (η5-C5H5)Ti (η8-C8H8)Ti wire has unique half-metallic properties with 100% spin polarization near the Fermi level in the ground state. We predict that finite-layer [(C5H5)Ti (C8H8)] n clusters coupled to gold electrodes exhibit a near-perfect spin-filter effect. Furthermore, due to the large spin coherence originated from its organic nature, these devices possess a spin-valve effect with large magnetoresistance. Our findings suggest that such a multifunctional molecular device is an excellent candidate for future molecule-based spintronic applications.

  17. Synthesis of Key Points from the OSEP Early Childhood Transition FAQ (SPP/APR Indicators C-8, B-11 and B-12)

    Science.gov (United States)

    Diefendorf, M.; Henson, J.; Lucas, A.; Whaley, K.

    2010-01-01

    This document is a synthesis of the key points provided in the Office of Special Education Programs (OSEP) Early Childhood Transition FAQs: SPP/APR indicators C-8 and B-12 released on December 1, 2009. It was developed to assist states with the implementation of effective transition policies and practices. The following is included: (1) Transition…

  18. Construction of expression vector of recombinant vaccinia virus TianTan strain with C8L-K3L region deletion and study on biological properties of the recombinant virus%痘苗病毒天坛株C8L-K3L片段缺失表达载体的生物学性能研究

    Institute of Scientific and Technical Information of China (English)

    刘铮; 刘颖; 王书晖; 张其程; 刘莹; 侯爵; 王荣敏; 邵一鸣

    2013-01-01

    目的 研究缺失C8L-K3L片段的痘苗病毒天坛株载体的生物学性能及外源基因的免疫原性.方法 构建缺失C8L-K3L区域的重组痘苗病毒天坛株载体VTT△C8-K3-gag.在4种细胞上检测了重组载体的增殖能力、在小鼠和家兔模型上进行毒力评价,并在BALB/c小鼠进行了免疫效果评价.结果 与VTT相比,VTT△C8-K3-gag在CEF、BHK-21、HeLa细胞中复制能力显著下降,在Vero细胞中失去复制能力.VTT△C8-K3-gag在小鼠和家兔模型中毒力均有显著降低.VTT△C8-K3-gag免疫小鼠第4周后诱导的痘苗病毒特异结合抗体与中和抗体滴度分别达到5.6× 103和1.0× 104,第9周滴度达到5.8×105和5.25×103,与VTKgpe相比均显著下降3~9倍,但E3刺激后的细胞免疫应答无显著变化.VTT△C8-K3-gag单独免疫或与DNA疫苗联合免疫诱导的HIV特异性抗体水平和细胞免疫应答均与VTKgpe无差异.结论 VTT△C8-K3-gag是一个安全性较高且具有深入研究价值的HIV候选疫苗株.%Objective To study the biological properties of the recombinant vaccinia virus Tiantan strain with C8L-K3L region deletion and its immunogenicity.Methods The expression vector of recombinant vaccinia virus TianTan strain (VTT△C8-K3-gag) was constructed by replacing C8L-K3L genes with HIV gag gene and GFP gene.Viral replication capacities in chicken CEF,hamster BHK-21,monkey Vero and human HeLa cell lines were detected respectively.Virulence evaluation was carried out in mice and rabbit models,and immune effects of VTT△C8-K3-gag was evaluated in BALA/c mice model.Results The replication capacity of VTT△C8-K3-gag was impaired in chicken CEF,hamster BHK-21 and human HeLa cell lines,and was completely restricted in monkey Vero cell line as compared with the parental VTT.VTT△C8-K3-gag was less virulent than VTT in mice and rabbit models.The cellular and humoral responses to HIV elicited by VTT△C8-K3-gag alone or in combination with DNA vaccine were similar

  19. Health transformation project and defensive medicine practice among neurosurgeons in Turkey

    OpenAIRE

    Solaroğlu, İhsan; Yeter, H. Gökçe; Metin, M. Mert; Keleş, Güven Evren; İzci, Yusuf

    2014-01-01

    Background: The term ""Defensive'' medicine was coined in the early 19709s and has been an important topic of scientific investigation and professional debate ever since. Objective: The aim of this study was to investigate the characteristics of defensive medicine, its reasons, and the extent to which it is practiced in the Turkish health care system. This is the first national survey to study the practice of defensive medicine among neurosurgeons in Turkey. Methods: The present cro...

  20. Seeing voices of health disparity: evaluating arts projects as influence processes.

    Science.gov (United States)

    Parsons, Janet; Heus, Lineke; Moravac, Catherine

    2013-02-01

    Arts-informed approaches are increasingly popular as vehicles for research, knowledge translation and for engaging key stakeholders on topics of health and health care. This paper describes an evaluation of a multimedia art installation intended to promote awareness of health disparities as experienced by homeless persons living in Toronto (Canada). The objective of the evaluation was to determine whether the installation had an impact on audience members, and if so, to understand its influence on viewers' perspectives on homelessness and the health concerns of homeless persons. Key themes were identified through the analysis of direct observational data of viewer interactions with the exhibit and qualitative interviews with different audience members after the exhibit. The four key themes were: (1) Promoting recognition of common humanity between viewers and viewed (challenging previously held assumptions and stereotypes, narrowing perceived social distance); (2) functions fulfilled (or potentially fulfilled) by the exhibit: raising awareness, educational applications, and potential pathways by which the exhibit could serve as a call to social action; (3) stories that prompt more stories: the stories within the exhibit (coupled with the interview questions) prompted further sharing of stories amongst the evaluation respondents, highlighting the iterative nature of such approaches. Respondents told of recognizing similarities in the experiences recounted in the exhibit with their own interactions with homeless persons; (4) strengths and weaknesses identified: including aesthetic features, issues of audience 'reach' and the importance of suitable venues for exhibition. Theoretically informed by narrative analysis and visual anthropology, this evaluation demonstrates that arts-informed 'interventions' are highly complex and work in subtle ways on viewers, allowing them to re-imagine the lives of others and identify points of common interest. It also problematizes our

  1. Performance Estimation of Networked Business Models: Case Study on a Finnish eHealth Service Project

    OpenAIRE

    Marikka Heikkilä; Sam Solaimani; Aki Soudunsaari; Mila Hakanen; Leni Kuivaniemi; Mari Suoranta

    2014-01-01

    Purpose: The objective of this paper is to propose and demonstrate a framework for estimating performance in a networked business model. Design/methodology/approach: Our approach is design science, utilising action research in studying a case of four independent firms in Health & Wellbeing sector aiming to jointly provide a new service for business and private customers. The duration of the research study is 3 years. Findings: We propose that a balanced set of performance indicators...

  2. The sustainability of donor funded projects in the health sector / T. Mitchell

    OpenAIRE

    Mitchell, Therese

    2013-01-01

    The need for donor funding has increased significantly over the last decade. Without donor funding millions of people wouldn’t be alive today. Thanks either to research finding a cure, successful treatment, funds donated for food, aid toward building infrastructure, or giving people the opportunity to further their education. Donor funding thus facilitates a better future. A literature review was conducted to give background on the health sector and how these funds were distributed, ethical c...

  3. Integrating Internet of Things and Cloud Computing for Health Services Provisioning: The Virtual Cloud Carer Project

    OpenAIRE

    Gachet Páez, Diego; Buenaga Rodríguez, Manuel de; Aparicio Galisteo, Fernando; Padrón Nápoles, Víctor Manuel

    2012-01-01

    The demographic and social changes are causing a gradual increase of the population in situation of dependency. The main concern of the elder people is their health and its consequences in terms of dependence and also is the primary cause of suffering and Ministerio de Industria, Turismo y Comercio (TSI-020100-2011-83); Ministerio de Ciencia e Innovación (TIN-2009-14057-C03-01). No data (2012)

  4. Contextual determinants of health behaviours in an aboriginal community in Canada: pilot project

    Directory of Open Access Journals (Sweden)

    Joseph Pamela

    2012-11-01

    Full Text Available Abstract Background Rapid change in food intake, physical activity, and tobacco use in recent decades have contributed to the soaring rates of obesity, type 2 diabetes and cardiovascular disease (CVD in Aboriginal populations living in Canada. The nature and influence of contextual factors on Aboriginal health behaviours are not well characterized. Methods To describe the contextual determinants of health behaviours associated with cardiovascular risk factors on the Six Nations reserve, including the built environment, access and affordability of healthy foods, and the use of tobacco. In this cross-sectional study, 63 adults from the Six Nations Reserve completed the modified Neighbourhood Environment Walkability Scale (NEWS, questionnaire assessing food access and availability, tobacco pricing and availability, and the Environmental Profile of Community Health (EPOCH tool. Results The structured environment of Six Nations Reserve scored low for walkability, street connectivity, aesthetics, safety, and access to walking and cycling facilities. All participants purchased groceries off-reserve, although fresh fruits and vegetables were reported to be available and affordable both on and off-reserve. On average $151/week is spent on groceries per family. Ninety percent of individuals report tobacco use is a problem in the community. Tobacco is easily accessible for children and youth, and only three percent of community members would accept increased tobacco taxation as a strategy to reduce tobacco access. Conclusions The built environment, access and affordability of healthy food and tobacco on the Six Nations Reserve are not perceived favourably. Modification of these contextual factors described here may reduce adverse health behaviours in the community.

  5. Short term respiratory health effects of ambient air pollution: results of the APHEA project in Paris.

    OpenAIRE

    Dab, W; S. Medina; Quénel, P; Le Moullec, Y; Le Tertre, A; THELOT, B; Monteil, C; LAMELOISE,P; Pirard, P.; Momas, I; Ferry, R; Festy, B

    1996-01-01

    STUDY OBJECTIVE: To quantify the short term respiratory health effects of ambient air pollution in the Paris area. DESIGN: Time series analysis of daily pollution levels using Poisson regression. SETTING: Paris, 1987-92. MEASUREMENTS AND MAIN RESULTS: Air pollution was monitored by measurement of black smoke (BS) (15 monitoring stations), sulphur dioxide (SO2), nitrogen dioxide (NO2), particulate matter less than 13 microns in diameter (PM13), and ozone (O3) (4 stations). Daily mortality and ...

  6. A process for the inclusion of Aboriginal People in health research: lessons from the Determinants of TB Transmission project.

    Science.gov (United States)

    Boffa, Jody; King, Malcolm; McMullin, Kathleen; Long, Richard

    2011-03-01

    The Determinants of TB Transmission (DTT) project, a federally-funded study covering the period April 1, 2006-March 31, 2013, and examining the determinants of TB transmission amongst the Canadian-born population (Aboriginal and non-Aboriginal) in the prairie provinces of Canada, took a novel approach to health research involving Aboriginal people. The methodology aligned itself with the recently published Canadian Institutes of Health Research (CIHR) Guidelines for Health Research Involving Aboriginal People and the established principles of Ownership, Control, Access, and Possession (OCAP). This article details the process by which collaboration with Aboriginal peoples was achieved, including the involvement of Aboriginal researchers, the development of Provincial Network Committees (PNCs), and communications with First Nations Chiefs and Council. Strengths of this methodology included Aboriginal organizational and community support with a high rate of participation; PNC leadership, which brought together Aboriginal stakeholders with provincial and federal TB program planners; and the exploration of both on and off-reserve transmission factors. Challenges of the methodology included meeting funding agency timelines and expectations given the gradual process of trust development and PNC-reviewed publication; respecting both community and individual participants' autonomy regarding study participation; and political discomfort with strong Aboriginal involvement. While the methodology required a dedicated investment from researchers and funding agencies alike, the process was worthwhile and achieved a high degree of support from its major collaborators: the Aboriginal peoples. PMID:21316828

  7. A Client-Centered Community Engagement Project: Improving the Health and Wellness of Older Adults in an Assisted Living Facility.

    Science.gov (United States)

    Ballantyne-Rice, Madeleine; Chopp, Kayla; Evans, Lisa; Ho, Vanessa; Hsiung, Wan Ping; Simon, Marian Alexandra; Wu, Kaiyu; Donnelly, Tam Truong

    2016-08-01

    Central to nursing practice is the promotion of health and wellness practices. Drawing on the Community as Partner Model, nursing process, Nursing Interventions Classification, and Logic Model, second-year nursing students collaborated with staff and residents of an assisted living facility to promote health and wellness in the older adult population. Windshield surveys, resident surveys, key informant interviews, and focus group interviews were conducted to gain insight into the perceptions and experiences of staff and residents. The majority of residents indicated they were satisfied with life at the facility and their needs have been adequately met. Strengths and areas for improvement were identified in several aspects, including the facility atmosphere and location, quality of staff and health care services, recreational and dietary services, and social support networks. By partnering with community key stakeholders, valuing all different perspectives, and connecting theory to practice, a successful client-centered community clinical project was demonstrated. [Journal of Gerontological Nursing, 42(8), 44-51.]. PMID:27263539

  8. If slow rate of health care spending growth persists, projections may be off by $770 billion.

    Science.gov (United States)

    Cutler, David M; Sahni, Nikhil R

    2013-05-01

    Despite earlier forecasts to the contrary, US health care spending growth has slowed in the past four years, continuing a trend that began in the early 2000s. In this article we attempt to identify why US health care spending growth has slowed, and we explore the spending implications if the trend continues for the next decade. We find that the 2007-09 recession, a one-time event, accounted for 37 percent of the slowdown between 2003 and 2012. A decline in private insurance coverage and cuts to some Medicare payment rates accounted for another 8 percent of the slowdown, leaving 55 percent of the spending slowdown unexplained. We conclude that a host of fundamental changes--including less rapid development of imaging technology and new pharmaceuticals, increased patient cost sharing, and greater provider efficiency--were responsible for the majority of the slowdown in spending growth. If these trends continue during 2013-22, public-sector health care spending will be as much as $770 billion less than predicted. Such lower levels of spending would have an enormous impact on the US economy and on government and household finances. PMID:23650316

  9. Inhibition of human cytochrome p450 2c8-catalyzed amodiaquine n-desethylation: Effect of five traditionally and commonly used herbs

    Directory of Open Access Journals (Sweden)

    Yasotha Devi Muthiah

    2016-01-01

    Full Text Available Background: In Southeast Asia and many parts of the world, herbal products are increasingly used in parallel with modern medicine. Objective: This study aimed to investigate the effects of herbs commonly used in Southeast Asia on activity of cytochrome P450 2C8 (CYP2C8, an important human hepatic enzyme in drug metabolism. Materials and Methods: The selected herbs, such as Eurycoma longifolia Jack (ELJ, Labisia pumila (LP, Echinacea purpurea (EP, Andrographis paniculata (AP, and Ginkgo biloba (GB, were subjected to inhibition studies using an in vitro CYP2C8 activity marker, amodiaquine N-desethylase assay. Inhibition parameters, inhibitory concentration 50% (IC50, and Kivalues were determined to study the potency and mode of inhibition. Results: All herbs inhibited CYP2C8 with the following order of potency: LP > ELJ > GB > AP > EP. LP and ELJ inhibited potently at Ki's of 2 and 4 times the Kiof quercetin, the positive control. The inhibition by LP was uncompetitive in nature as compared to competitive or mixed type inhibition observed with other herbs. GB exhibited moderate inhibitory effect at a Ki6 times larger than quercetin Ki. AP and EP, on the other hand, showed only weak inhibition. Conclusion: The herbs we chose represented the more commonly used herbs in Southeast Asia where collision of tradition and modernization in healthcare, if not properly managed, may lead to therapeutic misadventures. We conclude that concurrent consumption of some herbs, in particular, LP and ELJ, may have relevance in drug-herb interactions via CYP2C8 inhibition in vivo.

  10. In Vitro and In Vivo Drug-Drug Interaction Studies to Assess the Effect of Abiraterone Acetate, Abiraterone, and Metabolites of Abiraterone on CYP2C8 Activity.

    Science.gov (United States)

    Monbaliu, Johan; Gonzalez, Martha; Bernard, Apexa; Jiao, James; Sensenhauser, Carlo; Snoeys, Jan; Stieltjes, Hans; Wynant, Inneke; Smit, Johan W; Chien, Caly

    2016-10-01

    Abiraterone acetate, the prodrug of the cytochrome P450 C17 inhibitor abiraterone, plus prednisone is approved for treatment of metastatic castration-resistant prostate cancer. We explored whether abiraterone interacts with drugs metabolized by CYP2C8, an enzyme responsible for the metabolism of many drugs. Abiraterone acetate and abiraterone and its major metabolites, abiraterone sulfate and abiraterone sulfate N-oxide, inhibited CYP2C8 in human liver microsomes, with IC50 values near or below the peak total concentrations observed in patients with metastatic castration-resistant prostate cancer (IC50 values: 1.3-3.0 µM, 1.6-2.9 µM, 0.044-0.15 µM, and 5.4-5.9 µM, respectively). CYP2C8 inhibition was reversible and time-independent. To explore the clinical relevance of the in vitro data, an open-label, single-center study was conducted comprising 16 healthy male subjects who received a single 15-mg dose of the CYP2C8 substrate pioglitazone on day 1 and again 1 hour after the administration of abiraterone acetate 1000 mg on day 8. Plasma concentrations of pioglitazone, its active M-III (keto derivative) and M-IV (hydroxyl derivative) metabolites, and abiraterone were determined for up to 72 hours after each dose. Abiraterone acetate increased exposure to pioglitazone; the geometric mean ratio (day 8/day 1) was 125 [90% confidence interval (CI), 99.9-156] for Cmax and 146 (90% CI, 126-171) for AUClast Exposure to M-III and M-IV was reduced by 10% to 13%. Plasma abiraterone concentrations were consistent with previous studies. These results show that abiraterone only weakly inhibits CYP2C8 in vivo. PMID:27504016

  11. Evacetrapib: in vitro and clinical disposition, metabolism, excretion, and assessment of drug interaction potential with strong CYP3A and CYP2C8 inhibitors.

    Science.gov (United States)

    Cannady, Ellen A; Wang, Ming-Dauh; Friedrich, Stuart; Rehmel, Jessica L F; Yi, Ping; Small, David S; Zhang, Wei; Suico, Jeffrey G

    2015-10-01

    Evacetrapib is an investigational cholesteryl ester transfer protein inhibitor (CETPi) for reduction of risk of major adverse cardiovascular events in patients with high-risk vascular disease. Understanding evacetrapib disposition, metabolism, and the potential for drug-drug interactions (DDI) may help guide prescribing recommendations. In vitro, evacetrapib metabolism was investigated with a panel of human recombinant cytochromes P450 (CYP). The disposition, metabolism, and excretion of evacetrapib following a single 100-mg oral dose of (14)C-evacetrapib were determined in healthy subjects, and the pharmacokinetics of evacetrapib were evaluated in the presence of strong CYP3A or CYP2C8 inhibitors. In vitro, CYP3A was responsible for about 90% of evacetrapib's CYP-associated clearance, while CYP2C8 accounted for about 10%. In the clinical disposition study, only evacetrapib and two minor metabolites circulated in plasma. Evacetrapib metabolism was extensive. A mean of 93.1% and 2.30% of the dose was excreted in feces and urine, respectively. In clinical DDI studies, the ratios of geometric least squares means for evacetrapib with/without the CYP3A inhibitor ketoconazole were 2.37 for area under the curve (AUC)(0-∞) and 1.94 for C max. There was no significant difference in evacetrapib AUC(0-τ) or C max with/without the CYP2C8 inhibitor gemfibrozil, with ratios of 0.996 and 1.02, respectively. Although in vitro results indicated that both CYP3A and CYP2C8 metabolized evacetrapib, clinical studies confirmed that evacetrapib is primarily metabolized by CYP3A. However, given the modest increase in evacetrapib exposure and robust clinical safety profile to date, there is a low likelihood of clinically relevant DDI with concomitant use of strong CYP3A or CYP2C8 inhibitors. PMID:26516590

  12. Health-hazard evaluation report HETA 86-456-1877, South Texas Nuclear Project, Wadsworth, Texas

    International Nuclear Information System (INIS)

    An evaluation was made of an outbreak of dermatitis among workers at the South Texas Nuclear Project construction site, Wadsworth, Texas. The dermatitis occurred ten times more frequently among carpenters than other laborers, with the incidence in 1986 being 250% greater than it was in 1985. Some workers demonstrated pruritic, macular/papular lesions. Carpenters working on the inside of the power-project buildings had a higher incidence of skin disease than those employed on the outside of the buildings. Samples of plywood and lumber treated with fire-retardant indicated that they contained 3 and 5% phosphate, respectively. Arsenic was not detected but formaldehyde was detected at 59 parts per million. General environmental air samples were taken with no evidence found of airborne phosphate, melamine, dicyandiamide, or formaldehyde. Concentrations of total particulates ranged from 0.1 to 0.6mg/m3. The authors conclude that the workers were probably suffering from a contact dermatitis. The authors recommend specific precautions

  13. Projection models for health-effects assessment in populations exposed to radioactive and nonradioactive pollutants. Volume V. SPAHR programmer's guide

    Energy Technology Data Exchange (ETDEWEB)

    Collins, J.J.; Lundy, R.T.

    1982-09-01

    The Simulation Package for the Analysis of Health Risk (SPAHR) is a computer software package based upon a demographic model for health risk projections. The model extends several health risk projection models by making realistic assumptions about the population at risk, and thus represents a distinct improvement over previous models. Complete documentation for use of SPAHR is contained in this five-volume publication. The demographic model in SPAHR estimates population response to environmental toxic exposures. Latency of response, changing dose level over time, competing risks from other causes of death, and population structure can be incorporated into SPAHR to project health risks. Risks are measured by morbid years, numbers of deaths, and loss of life expectancy. Comparisons of estimates of excess deaths demonstrate that previous health risk projection models may have underestimated excess deaths by a factor of from 2 to 10, depending on the pollutant and the exposure scenario. The software supporting the use of the demographic model is designed to be user oriented. Complex risk projections are made by responding to a series of prompts generated by the package. The flexibility and ease of use of SPAHR make it an important contribution to existing models and software packages. This volume contains a programmer's guide to SPAHR.

  14. APPROACH AND TREATMENT OF SUICIDAL BEHAVIOR IN THE CLINICAL PRACTICE OF DIFFERENT GROUPS OF HEALTH PROFESSIONALS IN SPAIN: RESULTS OF THE PROJECT EUREGENA.

    Directory of Open Access Journals (Sweden)

    Juan Luis Muñoz

    2014-12-01

    Full Text Available According to the WHO (World Health Organization and the European Union, suicide is considered to be a health problem of prime importance and to be one of the principal causes of unnatural death. In Spain, the number of suicides has increased 12% since 2005 . The Research Project “European Regions Enforcing Actions against Suicide (EUREGENAS, funded by the Health Program 2008-2013, has as main objective the description of an integrated model of Mental Health orientated to the prevention of suicide. The differences that allow distinguishing the meaning of prevention in suicide behavior are described and explained through a qualitative methodological strategy and through the creation of discussion groups formed by different groups of health professionals. The results highlight the existing differences between the diverse health professionals who come more in contact with this problem and it shows as well the coincidence of meaning that suicide has to be considered as a priority in the field of health.

  15. Alternatives to project-specific consent for access to personal information for health research: Insights from a public dialogue

    Directory of Open Access Journals (Sweden)

    Abelson Julia

    2008-11-01

    Full Text Available Abstract Background The role of consent for research use of health information is contentious. Most discussion has focused on when project-specific consent may be waived but, recently, a broader range of consent options has been entertained, including broad opt-in for multiple studies with restrictions and notification with opt-out. We sought to elicit public values in this matter and to work toward an agreement about a common approach to consent for use of personal information for health research through deliberative public dialogues. Methods We conducted seven day-long public dialogues, involving 98 participants across Canada. Immediately before and after each dialogue, participants completed a fixed-response questionnaire rating individuals' support for 3 approaches to consent in the abstract and their consent choices for 5 health research scenarios using personal information. They also rated how confident different safeguards made them feel that their information was being used responsibly. Results Broad opt-in consent for use of personal information garnered the greatest support in the abstract. When presented with specific research scenarios, no one approach to consent predominated. When profit was introduced into the scenarios, consent choices shifted toward greater control over use. Despite lively and constructive dialogues, and considerable shifting in opinion at the individual level, at the end of the day, there was no substantive aggregate movement in opinion. Personal controls were among the most commonly cited approaches to improving people's confidence in the responsible use of their information for research. Conclusion Because no one approach to consent satisfied even a simple majority of dialogue participants and the importance placed on personal controls, a mechanism should be developed for documenting consent choice for different types of research, including ways for individuals to check who has accessed their medical record

  16. A web based health technology assessment in tele-echocardiography: the experience within an Italian project.

    Science.gov (United States)

    Giansanti, Daniele; Morelli, Sandra; Maccioni, Giovanni; Guerriero, Lorenzo; Bedini, Remo; Pepe, Gennaro; Colombo, Cesare; Borghi, Gabriella; Macellari, Velio

    2009-01-01

    Due to major advances in the information technology, telemedicine applications are ready for a widespread use. Nonetheless, to allow their diffusion in National Health Care Systems (NHCSs) specific methodologies of health technology assessment (HTA) should be used to assess the standardization, the overall quality, the interoperability, the addressing to legal, economic and cost benefit aspects. One of the limits to the diffusion of the digital tele-echocardiography (T-E) applications in the NHCS lacking of a specific methodology for the HTA. In the present study, a solution offering a structured HTA of T-E products was designed. The methodology assured also the definition of standardized quality levels for the application. The first level represents the minimum level of acceptance; the other levels are accessory levels useful for a more accurate assessment of the product. The methodology showed to be useful to rationalize the process of standardization and has received a high degree of acceptance by the subjects involved in the study.

  17. A web based health technology assessment in tele-echocardiography: the experience within an Italian project

    Directory of Open Access Journals (Sweden)

    Daniele Giansanti

    2009-12-01

    Full Text Available Due to major advances in the information technology, telemedicine applications are ready for a widespread use. Nonetheless, to allow their diffusion in National Health care Systems (NHcSs specific methodologies of health technology assessment (HTA should be used to assess the standardization, the overall quality, the interoperability, the addressing to legal, economic and cost benefit aspects. One of the limits to the diffusion of the digital tele-echocardiography (T-E applications in the NHcS lacking of a specific methodology for the HTA. In the present study, a solution offering a structured HTA of T-E products was designed. The methodology assured also the definition of standardized quality levels for the application. The first level represents the minimum level of acceptance; the other levels are accessory levels useful for a more accurate assessment of the product. The methodology showed to be useful to rationalize the process of standardization and has received a high degree of acceptance by the subjects involved in the study.

  18. Franco-German initiative for Chernobylsk health project; Initiative Franco-Allemande pour Tchernobyl projet sante

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The works led within the framework of the French-German initiative ( I.F.A.) on the health of the populations exposed to the ionizing radiations concentrated on the main useful indicators of health for the study of the excess incidence of cancers after a relatively long latency period. No net difference of the tendencies of leukaemia incidence was revealing between exposed regions and not exposed regions of Ukraine, Belarus and Russia. As regards solid tumors, the rates of incidence presented the same tendencies of increase in the course of time whatever are the studied regions. On the other hand, the works showed a net increase of the rate of incidence of the thyroid cancers in the exposed regions, notably at the aged persons of less than ten years at the time of the accident. In Belarus, the national register of cancers allowed to bring to light a very high number of thyroid cancers, from the beginning 1990 at the children of less than 15 years and net increase of these cancers, since 1998, in the slice of 15/29 the years. So for this exposed population, the risk of thyroid cancer continues to express itself 20 years after the accident. Besides, no tangible difference from the point of view of the tendencies between exposed and not exposed regions was revealing for the congenital malformations. (N.C.)

  19. Reusable Services from the neuGRID Project for Grid-Based Health Applications

    CERN Document Server

    Anjum, Ashiq; Habib, Irfan; Lansdale, Tom; McClatchey, Richard; Mehmood, Yasir

    2012-01-01

    By abstracting Grid middleware specific considerations from clinical research applications, re-usable services should be developed that will provide generic functionality aimed specifically at medical applications. In the scope of the neuGRID project, generic services are being designed and developed which will be applied to satisfy the requirements of neuroscientists. These services will bring together sources of data and computing elements into a single view as far as applications are concerned, making it possible to cope with centralised, distributed or hybrid data and provide native support for common medical file formats. Services will include querying, provenance, portal, anonymization and pipeline services together with a 'glueing' service for connection to Grid services. Thus lower-level services will hide the peculiarities of any specific Grid technology from upper layers, provide application independence and will enable the selection of 'fit-for-purpose' infrastructures. This paper outlines the desi...

  20. [Projections and expectations of students enrolled in a teaching qualification in a technical health professional education course].

    Science.gov (United States)

    Marin, Maria José Sanches; Tonhom, Silvia Franco da Rocha; Michelone, Adriana Paula Congro; Higa, Elza de Fátima Ribeiro; Bernardo, Mário do Carmo Martini; Tavares, Cláudia Mara de Melo

    2013-02-01

    This research aims at analyzing the projections and expectations of students enrolled in a teaching qualification in technical health professional education course, aiming at overcoming disciplinary fragmentation and further approaching the working world. This was a qualitative study that included interviews with 33 students enrolled in the course, and the data analysis was performed using a content analysis technique. The following categories were identified among the results: the possibility of teaching-learning; the need for pedagogical qualification and the constant search for learning; and the possibility of changing reality. We conclude that students enrolled in this course foresee the transformation of their social reality, taking into account the need to acquire new skills and professional competences to effectively perform their job and compete within the working world.

  1. Impact of a Child-Based Health Promotion Service-Learning Project on the Growth of Occupational Therapy Students.

    Science.gov (United States)

    Lau, Cynthia

    2016-01-01

    This phenomenological study revealed the lived experiences of occupational therapy students as they embarked on a semester-long volunteer health promotion service-learning project during their entry-level master's program. Data analysis extrapolated themes from student journals, transcriptions of pre- and postinterviews, and field notes. Student roles were exemplified by what students wanted to learn, what they actually learned, and the unexpected benefits they experienced. In particular, issues with teaming, interprofessional development, and time management were discovered. The findings add to the growing literature about the benefits of service learning as a teaching strategy and how it facilitates mindfulness of community service, communication, and clinical reasoning of future therapists. Implications for learning and practice are discussed. PMID:27548859

  2. The Apollo Medical Operations Project: Recommendations to improve crew health and performance for future exploration missions and lunar surface operations

    Science.gov (United States)

    Scheuring, Richard A.; Jones, Jeffrey A.; Novak, Joseph D.; Polk, James D.; Gillis, David B.; Schmid, Josef; Duncan, James M.; Davis, Jeffrey R.

    Introduction: Medical requirements for the future crew exploration vehicle (CEV), lunar surface access module (LSAM), advanced extravehicular activity (EVA) suits, and Lunar habitat are currently being developed within the exploration architecture. While much is known about the vehicle and lunar surface activities during Apollo, relatively little is known about whether the hardware, systems, or environment impacted crew health or performance during these missions. Also, inherent to the proposed aggressive surface activities is the potential risk of injury to crewmembers. The Space Medicine Division at the NASA Johnson Space Center (JSC) requested a study in December 2005 to identify Apollo mission issues relevant to medical operations impacting crew health and/or performance during a lunar mission. The goals of this project were to develop or modify medical requirements for new vehicles and habitats, create a centralized database for future access, and share relevant Apollo information with various working groups participating in the exploration effort. Methods: A review of medical operations during Apollo missions 7-17 was conducted. Ten categories of hardware, systems, or crew factors were identified during preliminary data review generating 655 data records which were captured in an Access® database. The preliminary review resulted in 285 questions. The questions were posed to surviving Apollo crewmembers using mail, face-to-face meetings, phone communications, or online interactions. Results: Fourteen of 22 surviving Apollo astronauts (64%) participated in the project. This effort yielded 107 recommendations for future vehicles, habitats, EVA suits, and lunar surface operations. Conclusions: To date, the Apollo Medical Operations recommendations are being incorporated into the exploration mission architecture at various levels and a centralized database has been developed. The Apollo crewmember's input has proved to be an invaluable resource. We will continue

  3. Comparison of Responses to Mn Deficiency Between the UK Wheat Genotypes Maris Butler, Paragon and the Australian Wheat Genotype C8MM

    Institute of Scientific and Technical Information of China (English)

    Wen-Zhi Jiang

    2008-01-01

    Wheat grown in Mn-deficient soil has been widely observed to produce much reduced yields. Breeding for Mn-efficient wheat genotypes adapted to Mn-deficient soils would represent a long-term solution for wheat agronomy, To characterize the physiological basis of Mn efficiency in wheat genotypes would facilitate the breeding programs for producing Mn-efficient wheat. Using a solution culture and a soil culture system in the present study, a Mn-efficient UK wheat genotype Maris Butler and a Mn-inefficient UK wheat genotype Paragon have been compared with a Mn-efficient Australian wheat genotype C8MM in the responses to Mn deficiency In order to characterize the Mn efficiency in these wheat genotypes.Results showed that in solution culture, Marls Butler grown under Mn deficiency had 77% relative dry matter yield of control plants that were grown under Mn sufficiency, whereas C8MM and Paragon had 60% and 58% relative dry matter yield of their respective controls. Results from the soil culture demonstrated that relative dry matter yield remained high for Marie Butler and C8MM (53% and 56%, respectively), whereas the value for Paragon dropped to 33%. In terms of dry matter yield and photosynthetic efficiency, Mads Butler demonstrated Mn efficiency in both solution culture and soil culture, whereas C8MM showed Mn efficiency only In soil culture. Results also demonstrated that under Mn-depleted supply in soil, plants of C8MM had a significantly higher ability in Mn uptake, whereas plants of Marls Butler showed a higher internal Mn usa efficiency in comparison with plants of Paragon. Results from the present study indicate that the ability of C8MM to accumulate higher amounts of Mn is the basis of the improved Mn efficiency of this genotype in comparison with Paragon, and in Marls Butler there is a higher internal use of Mn expressed as an improved photosynthetic efficiency in conferring its Mn efficiency. It is suggested that more than one mechanism has arisen in wheat to

  4. Comprehensive chemical kinetic modeling of the oxidation of C8 and larger n-alkanes and 2-methylalkanes

    Energy Technology Data Exchange (ETDEWEB)

    Sarathy, S M; Westbrook, C K; Pitz, W J; Mehl, M; Togbe, C; Dagaut, P; Wang, H; Oehlschlaeger, M; NIemann, U; Seshadri, K; Veloo, P S; Ji, C; Egolfopoulos, F; Lu, T

    2011-03-16

    Conventional petroleum jet and diesel fuels, as well as alternative Fischer-Tropsch (FT) fuels and hydrotreated renewable jet (HRJ) fuels, contain high molecular weight lightly branched alkanes (i.e., methylalkanes) and straight chain alkanes (n-alkanes). Improving the combustion of these fuels in practical applications requires a fundamental understanding of large hydrocarbon combustion chemistry. This research project presents a detailed and reduced chemical kinetic mechanism for singly methylated iso-alkanes (i.e., 2-methylalkanes) ranging from C{sub 8} to C{sub 20}. The mechanism also includes an updated version of our previously published C{sub 8} to C{sub 16} n-alkanes model. The complete detailed mechanism contains approximately 7,200 species 31,400 reactions. The proposed model is validated against new experimental data from a variety of fundamental combustion devices including premixed and nonpremixed flames, perfectly stirred reactors and shock tubes. This new model is used to show how the presence of a methyl branch affects important combustion properties such as laminar flame propagation, ignition, and species formation.

  5. Scale-up of community-based malaria control can be achieved without degrading community health workers' service quality: the Village Malaria Worker project in Cambodia

    OpenAIRE

    Yasuoka Junko; Poudel Krishna C; Ly Po; Nguon Chea; Socheat Duong; Jimba Masamine

    2012-01-01

    Abstract Background Malaria control has been scaled up in many developing countries in their efforts to achieve the Millennium Development Goals. Cambodia recently scaled up their Village Malaria Worker (VMW) project by substantially increasing the number of VMWs and expanding the project's health services to include treatment of fever, diarrhoea, and Acute Respiratory Infections (ARI) in children under five. This study examined if the scale-up interfered with VMWs' service quality, actions, ...

  6. Regulatory analysis for the resolution of generic issue C---8, main steam isolation valve leakage and LCS [leakage control system] failure

    International Nuclear Information System (INIS)

    Generic Issue C-8 deals with staff concerns about public risk because of the incidence of leak test failures reported for main steam isolation valves (MSIVs) at boiling water reactors and the limitations of the leakage control systems (LCSs) for mitigating the consequences of leakage from these valves. If the MSIV leakage is greatly in excess of the allowable value in the technical specifications, the LCS would be unavailable because of design limitations. The issue was initiated in 1983 to assess (1) the causes of MSIV leakage failures, (2) the effectiveness of the LCS and alternative mitigation paths, and (3) the need for additional regulatory action to reduce public risk. This report presents the regulatory analysis for Generic Issue C-8 and concludes that no new regulatory requirements are warranted

  7. Orientation-dependent energy level alignment and film growth of 2,7-diocty[1]benzothieno[3,2-b]benzothiophene (C8-BTBT) on HOPG

    International Nuclear Information System (INIS)

    Combining ultraviolet photoemission spectroscopy, X-ray photoemission spectroscopy, atomic force microscopy, and X-ray diffraction measurements, we performed a systematic investigation on the correlation of energy level alignment, film growth, and molecular orientation of 2,7-diocty[1]benzothieno[3,2-b]benzothiophene (C8-BTBT) on highly oriented pyrolytic graphite. The molecules lie down in the first layer and then stand up from the second layer. The ionization potential shows a sharp decrease from the lying down region to the standing up region. When C8-BTBT molecules start standing up, unconventional energy level band-bending-like shifts are observed as the film thickness increases. These shifts are ascribed to gradual decreasing of the molecular tilt angle about the substrate normal with the increasing film thickness

  8. Orientation-dependent energy level alignment and film growth of 2,7-diocty[1]benzothieno[3,2-b]benzothiophene (C8-BTBT) on HOPG

    Energy Technology Data Exchange (ETDEWEB)

    Lyu, Lu; Niu, Dongmei, E-mail: mayee@csu.edu.cnmailto; Xie, Haipeng; Cao, Ningtong; Zhang, Hong; Zhang, Yuhe; Liu, Peng [Institute of Super-Microstructure and Ultrafast Process in Advanced Materials, School of Physics and Electronics, Central South University, No. 605 Lushan South Road, Changsha, Hunan 410012 (China); Hunan Key Laboratory for Super-Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha, Hunan 410012 (China); Gao, Yongli [Institute of Super-Microstructure and Ultrafast Process in Advanced Materials, School of Physics and Electronics, Central South University, No. 605 Lushan South Road, Changsha, Hunan 410012 (China); Hunan Key Laboratory for Super-Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha, Hunan 410012 (China); Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627 (United States)

    2016-01-21

    Combining ultraviolet photoemission spectroscopy, X-ray photoemission spectroscopy, atomic force microscopy, and X-ray diffraction measurements, we performed a systematic investigation on the correlation of energy level alignment, film growth, and molecular orientation of 2,7-diocty[1]benzothieno[3,2-b]benzothiophene (C8-BTBT) on highly oriented pyrolytic graphite. The molecules lie down in the first layer and then stand up from the second layer. The ionization potential shows a sharp decrease from the lying down region to the standing up region. When C8-BTBT molecules start standing up, unconventional energy level band-bending-like shifts are observed as the film thickness increases. These shifts are ascribed to gradual decreasing of the molecular tilt angle about the substrate normal with the increasing film thickness.

  9. Performance Estimation of Networked Business Models: Case Study on a Finnish eHealth Service Project

    Directory of Open Access Journals (Sweden)

    Marikka Heikkilä

    2014-08-01

    Full Text Available Purpose: The objective of this paper is to propose and demonstrate a framework for estimating performance in a networked business model. Design/methodology/approach: Our approach is design science, utilising action research in studying a case of four independent firms in Health & Wellbeing sector aiming to jointly provide a new service for business and private customers. The duration of the research study is 3 years. Findings: We propose that a balanced set of performance indicators can be defined by paying attention to all main components of the business model, enriched with of network collaboration. The results highlight the importance of measuring all main components of the business model and also the business network partners’ view on trust, contracts and fairness. Research implications: This article contributes to the business model literature by combining business modelling with performance evaluation. The article points out that it is essential to create metrics that can be applied to evaluate and improve the business model blueprints, but it is also important to measure business collaboration aspects. Practical implications: Companies have already adopted Business model canvas or similar business model tools to innovate new business models. We suggest that companies continue their business model innovation work by agreeing on a set of performance metrics, building on the business model components model enriched with measures of network collaboration. Originality/value: This article contributes to the business model literature and praxis by combining business modelling with performance evaluation.

  10. Conceptual Site Treatment Plan Laboratory for Energy-Related Health Research Environmental Restoration Project

    Energy Technology Data Exchange (ETDEWEB)

    Chapman, T.E.

    1993-10-01

    The Federal Facilities Compliance Act (the Act) of 1992 waives sovereign immunity for federal facilities for fines and penalties under the provisions of the Resource Recovery and Conservation Act, state, interstate, and local hazardous and solid waste management requirements. However, for three years the Act delays the waiver for violations involving US Department of Energy (DOE) facilities. The Act, however, requires that the DOE prepare a Conceptual Site Treatment Plan (CSTP) for each of its sites that generate or store mixed wastes (MWs). The purpose of the CSTP is to present DOE`s preliminary evaluations of the development of treatment capacities and technologies for treating a site`s MW. This CSTP presents the preliminary capacity and technology evaluation for the Laboratory for Energy-Related Health Research (LEHR). The five identified MW streams at LEHR are evaluated to the extent possible given available information. Only one MW stream is sufficiently well defined to permit a technology evaluation to be performed. Two other MW streams are in the process of being characterized so that an evaluation can be performed. The other two MW streams will be generated by the decommissioning of inactive facilities onsite within the next five years.

  11. Conceptual Site Treatment Plan Laboratory for Energy-Related Health Research Environmental Restoration Project

    International Nuclear Information System (INIS)

    The Federal Facilities Compliance Act (the Act) of 1992 waives sovereign immunity for federal facilities for fines and penalties under the provisions of the Resource Recovery and Conservation Act, state, interstate, and local hazardous and solid waste management requirements. However, for three years the Act delays the waiver for violations involving US Department of Energy (DOE) facilities. The Act, however, requires that the DOE prepare a Conceptual Site Treatment Plan (CSTP) for each of its sites that generate or store mixed wastes (MWs). The purpose of the CSTP is to present DOE's preliminary evaluations of the development of treatment capacities and technologies for treating a site's MW. This CSTP presents the preliminary capacity and technology evaluation for the Laboratory for Energy-Related Health Research (LEHR). The five identified MW streams at LEHR are evaluated to the extent possible given available information. Only one MW stream is sufficiently well defined to permit a technology evaluation to be performed. Two other MW streams are in the process of being characterized so that an evaluation can be performed. The other two MW streams will be generated by the decommissioning of inactive facilities onsite within the next five years

  12. The Service Laboratory - A GTZ-BgVV project: Health protection through adapted veterinary diagnostic techniques

    International Nuclear Information System (INIS)

    The customary diagnostic methods of today have been developed in industrialized countries. High costs for personnel resulted in a trend towards automation and prefabricated test kits. Consequently, these techniques are not sufficiently adapted to local conditions in developing countries, where, as a rule, skilled and ancillary staff is available whereas foreign currency reserves for purchasing laboratory equipment and material from abroad are rather limited. Furthermore, the training of personnel from developing countries has usually been oriented towards thenon-transferable standards and methods of industrialized countries. This leads to a long term dependence of the diagnostic services on external funding. A diagnostic technology adapted to the specific local conditions of developing countries is needed to overcome this situation. The project activities concentrate on serological diagnostic work. Here, basic knowledge of the common diagnostic techniques and their set-up for specific diseases, methods for the production of related reagents (antigens, antibodies, conjugates, complement, etc.) and cleaning procedures for the reuse of 'one way' plastic material is spread by training programmes, specific publications and information leaflets. For two of the more complex test procedures, the most frequently quoted prescribed test for international trade, CFT, and the increasingly important ELISA (OIE, Manual of Standards for Diagnostic Techniques, Paris, 1992), we have calculated the cost reduction potential of adaptation through self-production of reagents and reuse of plastic materials. Material costs per microtitre test plate for the diagnosis of brucellosis can be reduced from US $3.79 to 0.82 for CFT and from US $3.88 to 1.13 for ELISA. In comparison, commercial ELISA kits cost about US $80 to 90 per plate (e.g. Bommeli, IDEXX, Boehringer)

  13. Understanding the Electronic Structures and Absorption Properties of Porphyrin Sensitizers YD2 and YD2-o-C8 for Dye-Sensitized Solar Cells

    Directory of Open Access Journals (Sweden)

    Zi-Jiang Liu

    2013-10-01

    Full Text Available The electronic structures and excitation properties of dye sensitizers determine the photon-to-current conversion efficiency of dye sensitized solar cells (DSSCs. In order to understand the different performance of porphyrin dye sensitizers YD2 and YD2-o-C8 in DSSC, their geometries and electronic structures have been studied using density functional theory (DFT, and the electronic absorption properties have been investigated via time-dependent DFT (TDDFT with polarizable continuum model for solvent effects. The geometrical parameters indicate that YD2 and YD2-o-C8 have similar conjugate length and charge transfer (CT distance. According to the experimental spectra, the HSE06 functional in TDDFT is the most suitable functional for describing the Q and B absorption bands of porphyrins. The transition configurations and molecular orbital analysis suggest that the diarylamino groups are major chromophores for effective CT excitations (ECTE, and therefore act as electron donor in photon-induced electron injection in DSSCs. The analysis of excited states properties and the free energy changes for electron injection support that the better performance of YD2-o-C8 in DSSCs result from the more excited states with ECTE character and the larger absolute value of free energy change for electron injection.

  14. Cloning and molecular characterization of complement component 1 inhibitor (C1INH) and complement component 8β (C8β) in Nile tilapia (Oreochromis niloticus).

    Science.gov (United States)

    He, Anyuan; Yang, Jie; Tang, Shoujie; Wang, Chenghui

    2013-09-01

    Nile tilapia (Oreochromis niloticus), one of the most important groups of food fishes in the world, has frequently suffered from serious challenge from pathogens in recent years. Immune responses of Nile tilapia should be understood to protect the aquaculture industry of this fish. The complement system has an important function in recognizing bacteria, opsonizing these pathogens by phagocytes, or killing them by direct lysis. In this study, two Nile tilapia complement component genes, complement component 1 inhibitor (C1INH) and complement component 8β subunit (C8β), were cloned and their expression characteristics were analyzed. C1INH cDNA was found containing a 1791 bp open reading frame (ORF) encoding a putative protein with 597 amino acids, a 101 bp 5'-untranslated region (UTR) and a 236 bp 3'-UTR. The predicted protein structure for this gene consisted of two Ig-like domains and glycosyl hydrolase family-9 active site signature 2. The C8β cDNA consisted of a 1761 bp ORF encoding 587 amino acids, a 15 bp 5'-UTR and a 170 bp 3'-UTR. The predicted protein of C8β contained three motifs, thrombospondin type-1 repeat, membrane attack complex/perforin domain, and LDL-receptor class A. Expression analysis revealed that these two complement genes were highly expressed in the liver, however, were weakly expressed in the gill, heart, brain, kidney, intestine, spleen and dorsal muscle tissues. The present study provided insights into the complement system and immune functions of Nile tilapia.

  15. Congener-specific organic carbon-normalized soil and sediment-water partitioning coefficients for the C1 through C8 perfluoroalkyl carboxylic and sulfonic acids.

    Science.gov (United States)

    Rayne, Sierra; Forest, Kaya

    2009-11-01

    Organic carbon-normalized soil and sediment-water partitioning coefficients (K(oc)) were estimated for all C(1) through C(8) perfluoroalkyl carboxylic (PFCA) and sulfonic (PFSA) acid congeners. The limited experimental K(oc) data set for the straight chain C(7) through C(10) PFCAs and C(8) and C(10) PFSAs was correlated to SPARC and ALOGPS computationally estimated octanol-water partitioning/distribution constants and used to predict K(oc) values for both branched and linear C(1) through C(8) isomers. Branched and linear congeners in this homologue range are generally expected to have K(oc) values > 1, leading to their accumulation in organic matter on sediments and soils, retardation during ground and pore water flow, and the preferential association with dissolved organic matter in aquatic systems. Both increasing perfluoroalkyl chain length and linearity increase K(oc) values with substantial intra- and inter-homologue variation and interhomologue mixing. Variability in K(oc) values among the PFCA and PFSA congeners will likely lead to an enrichment of more linear and longer-chain isomers in organic matter fractions, resulting in aqueous phases fractionated towards shorter-chain branched congeners. The expected magnitude of fractionation will require inclusion in source apportionment models and risk assessments. A comparison of representative established quantitative structure property relationships for estimating K(oc) values from octanol-water partitioning constants suggests that these equilibrium partitioning frameworks may be applicable towards modeling PFCA and PFSA environmental fate processes. PMID:20183495

  16. Community-based participatory research projects and policy engagement to protect environmental health on St Lawrence Island, Alaska

    Directory of Open Access Journals (Sweden)

    Pamela K. Miller

    2013-08-01

    Full Text Available Objectives . This article synthesizes discussion of collaborative research results, interventions and policy engagement for St Lawrence Island (SLI, Alaska, during the years 2000–2012. Methods . As part of on-going community-based participatory research (CBPR studies on SLI, 5 discrete exposure-assessment projects were conducted: (a a biomonitoring study of human blood serum; (b–d 3 investigations of levels of contaminants in environmental media at an abandoned military site at Northeast Cape – using sediment cores and plants, semi-permeable membrane devices and blackfish, respectively; and (e a study of traditional foods. Results . Blood serum in residents of SLI showed elevated levels of polychlorinated biphenyls (PCBs with higher levels among those exposed to the military site at Northeast Cape, an important traditional subsistence-use area. Environmental studies at the military site demonstrated that the site is a continuing source of PCBs to a major watershed, and that clean-up operations at the military site generated PCB-contaminated dust on plants in the region. Important traditional foods eaten by the people of SLI showed elevated concentrations of PCBs, which are primarily derived from the long-range transport of persistent pollutants that are transported by atmospheric and marine currents from more southerly latitudes to the north. Interventions . An important task for all CBPR projects is to conduct intervention strategies as needed in response to research results. Because of the findings of the CBPR projects on SLI, the CBPR team and the people of the Island are actively engaging in interventions to ensure cleanup of the formerly used military sites; reform chemicals policy on a national level; and eliminate persistent pollutants internationally. The goal is to make the Island and other northern/Arctic communities safe for themselves and future generations. Conclusions . As part of the CBPR projects conducted from 2000 to 2012

  17. THE VAXED PROJECT: An Assessment of Immunization Education in Canadian Health Professional Programs

    Directory of Open Access Journals (Sweden)

    Baxendale Darlene M

    2010-11-01

    Full Text Available Abstract Background Knowledge & attitudes of healthcare providers (HCP have significant impact on frequency with which vaccines are offered & accepted but many HCP are ill equipped to make informed recommendations about vaccine merits & risks. We performed an assessment of the educational needs of trainees regarding immunization and used the information thus ascertained to develop multi-faceted, evaluable, educational tools which can be integrated into formal education curricula. Methods (i A questionnaire was sent to all Canadian nursing, medical & pharmacy schools to assess immunization-related curriculum content (ii A 77-item web-based, validated questionnaire was emailed to final-year students in medicine, nursing, & pharmacy at two universities in Nova Scotia, Canada to assess knowledge, attitudes, & behaviors reflecting current immunization curriculum. Results The curriculum review yielded responses from 18%, 48%, & 56% of medical, nursing, & pharmacy schools, respectively. Time spent on immunization content varied substantially between & within disciplines from 50 hrs. Most schools reported some content regarding vaccine preventable diseases, immunization practice & clinical skills but there was considerable variability and fewer schools had learning objectives or formal evaluation in these areas. 74% of respondents didn't feel comfortable discussing vaccine side effects with parents/patients & only 21% felt they received adequate teaching regarding immunization during training. Conclusions Important gaps were identified in the knowledge of graduating nursing, medical, & pharmacy trainees regarding vaccine indications/contraindications, adverse events & safety. The national curriculum review revealed wide variability in immunization curriculum content & evaluation. There is clearly a need for educators to assess current curricula and adapt existing educational resources such as the Immunization Competencies for Health Professionals in

  18. Atmospheric histories and growth trends of C4F10, C5F12, C6F14, C7F16 and C8F18

    Directory of Open Access Journals (Sweden)

    R. F. Weiss

    2012-02-01

    Full Text Available The first atmospheric observations and trends are presented for the high molecular weight perfluorocarbons (PFCs: decafluorobutane (C4F10, dodecafluoropentane (C5F12, tetradecafluorohexane (C6F14, hexadecafluoroheptane (C7F16 and octadecafluorooctane (C8F18. Their atmospheric histories are based on measurements of 38 Northern Hemisphere and 46 Southern Hemisphere archived air samples collected between 1973 to 2011 using the Advanced Global Atmospheric Gases Experiment (AGAGE "Medusa" preconcentration gas chromatography-mass spectrometry systems. A new calibration scale was prepared for each PFC, with estimated accuracies of 6.8% for C4F10, 7.8% for C5F12, 4.0% for C6F14, 6.6% for C7F16 and 7.9% for C8F18. Based on our observations the 2011 globally averaged dry air mole fractions of these heavy PFCs are: 0.18 parts-per-trillion (ppt, i.e., parts per 1012 for C4F10, 0.12 ppt for C5F12, 0.28 ppt for C6F14, 0.12 ppt for C7F16 and 0.09 ppt for C8F18. These atmospheric mole fractions combine to contribute to a global average radiative forcing of 0.35 mW m−2, which is 3.6% of the total PFC radiative forcing. The globally averaged mean atmospheric growth rates of these PFCs during 1973–2011 are 4.58 parts per quadrillion (ppq, i.e., parts per 1015 per year (yr for C4F10, 3.29 ppq yr−1 for C5F12, 7.50 ppq yr−1 for C6F14, 3.19 ppq yr−1 for C7F16 and 2.51 ppq yr−1 for C8F18. The growth rates of the heavy perfluorocarbons were largest in the early 1990s for C4F10 and C5F12 and in the mid-to-late 1990s for C6F14, C7F16 and C8F18. The more recent slow down in the growth rates of the high molecular weight PFCs suggests that emissions are declining as compared to the 1980s and 1990s. Nevertheless continued monitoring of these potent, extremely long-lived greenhouse gases is necessary to verify that global PFC emissions continue to decline.

  19. Effects of sintering processes on mechanical properties and microstructure of TiB2–TiC + 8 wt% nano-Ni composite ceramic cutting tool material

    International Nuclear Information System (INIS)

    Highlights: ► TiB2–TiC + 8 wt% nano-Ni ceramic tool material was sintered by six processes. ► The properties of material depended mainly on the holding stages and duration. ► SP1 process was involved with the multiple holding stages and longer duration. ► SP1 process led to many pores, and coarsening and brittle rupture of grains. ► Tool material sintered by SP6 process exhibited the optimum mechanical properties. - Abstract: TiB2–TiC composite powder was prepared by ball-milled with ethanol and vacuum dry, and TiB2–TiC + 8 wt% nano-Ni composite ceramic cutting tool material was sintered using vacuum hot-pressed sintering technique by six processes which included the different holding stages and times. The effects of sintering processes on the mechanical properties and microstructure were investigated. The polished surface and fracture surface of TiB2–TiC + 8 wt% nano-Ni ceramics sintered by the different sintering processes were observed by scanning electron microscope (SEM), X-ray diffraction (XRD) and energy-dispersive spectrometry (EDS), and the relationships between mechanical properties and microstructure were discussed. The mechanical properties and microstructure depended mainly on the total holding time and the different holding stages. The longer holding time and multiple holding stages led to coarsening of TiB2 and TiC grains, formation of pores and the brittle rupture of grains, which deteriorated the mechanical properties of TiB2–TiC + 8 wt% nano-Ni ceramic. TiB2–TiC + 8 wt% nano-Ni composite ceramic cutting tool material sintered by SP6 process exhibited the optimum resultant mechanical properties because of its finer microstructure and higher relative density, and its flexural strength, fracture toughness and hardness were 916.8 MPa, 7.80 MPa m1/2 and 22.54 GPa, respectively.

  20. Atmospheric histories and growth trends of C4F10, C5F12, C6F14, C7F16 and C8F18

    Directory of Open Access Journals (Sweden)

    R. F. Weiss

    2012-05-01

    Full Text Available Atmospheric observations and trends are presented for the high molecular weight perfluorocarbons (PFCs: decafluorobutane (C4F10, dodecafluoropentane (C5F12, tetradecafluorohexane (C6F14, hexadecafluoroheptane (C7F16 and octadecafluorooctane (C8F18. Their atmospheric histories are based on measurements of 36 Northern Hemisphere and 46 Southern Hemisphere archived air samples collected between 1973 to 2011 using the Advanced Global Atmospheric Gases Experiment (AGAGE "Medusa" preconcentration gas chromatography-mass spectrometry systems. A new calibration scale was prepared for each PFC, with estimated accuracies of 6.8% for C4F10, 7.8% for C5F12, 4.0% for C6F14, 6.6% for C7F16 and 7.9% for C8F18. Based on our observations the 2011 globally averaged dry air mole fractions of these heavy PFCs are: 0.17 parts-per-trillion (ppt, i.e., parts per 1012 for C4F10, 0.12 ppt for C5F12, 0.27 ppt for C6F14, 0.12 ppt for C7F16 and 0.09 ppt for C8F18. These atmospheric mole fractions combine to contribute to a global average radiative forcing of 0.35 mW m−2, which is 6% of the total anthropogenic PFC radiative forcing (Montzka and Reimann, 2011; Oram et al., 2012. The growth rates of the heavy perfluorocarbons were largest in the late 1990s peaking at 6.2 parts per quadrillion (ppq, i.e., parts per 1015 per year (yr for C4F10, at 5.0 ppq yr−1 for C5F12 and 16.6 ppq yr−1 for C6F14 and in the early 1990s for C7F16 at 4.7 ppq yr−1 and in the mid 1990s for C8F18 at 4.8 ppq yr−1. The 2011 globally averaged mean atmospheric growth rates of these PFCs are subsequently lower at 2.2 ppq yr−1 for C4F10, 1.4 ppq yr−1 for C5F12, 5.0 ppq yr−1 for C6F14, 3.4 ppq yr−1 for C7F16 and 0.9 ppq yr−1 for C8F18. The more recent slowdown in the growth rates suggests that emissions are declining as compared to the 1980s and 1990s.

  1. The WHISK (Women's Health: Increasing the Awareness of Science and Knowledge) Pilot Project: Recognizing Sex and Gender Differences in Women's Health and Wellness

    OpenAIRE

    Edwards, Lorece V.; Dennis, Sabriya; Weaks, Francesca

    2013-01-01

    Women's health encompasses a continuum of biological, psychological, and social challenges that differ considerably from those of men. Despite the remarkable advances in science, women's health and sex differences research is slowly gaining recognition and acceptance. It is important that women's health gain attention as women are usually the gatekeepers of care for the family. Women's health and health outcomes are strongly influenced by sex and gender differences as well as geography. Around t...

  2. Regioselective differences in C(8)- and N-oxidation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by human and rat liver microsomes and cytochromes P450 1A2.

    Science.gov (United States)

    Turesky, R J; Parisod, V; Huynh-Ba, T; Langouët, S; Guengerich, F P

    2001-07-01

    The metabolism of the mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) was investigated with human and rat liver microsomes, recombinant human cytochrome P450 1A2 (P450 1A2) expressed in Escherichia coli cells, and rat P450 1A2. Human liver microsomes and human P450 1A2 catalyzed the oxidation of the exocyclic amine group of MeIQx to form the genotoxic product 2-(hydroxyamino)-3,8-dimethylimidazo[4,5-f]quinoxaline (HONH-MeIQx). Human P450 1A2 also catalyzed the oxidation of C(8)-methyl group of MeIQx to form 2-amino-(8-hydroxymethyl)-3-methylimidazo[4,5-f]quinoxaline (8-CH(2)OH-IQx), 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carbaldehyde (IQx-8-CHO), and 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid (IQx-8-COOH). Thus, chemically stable C(8)-oxidation products of MeIQx may be useful biomarkers of P450 1A2 activity in humans. Rat liver microsomes were 10-15-fold less active than the human counterpart at both N-oxidation and C(8)-oxidation of MeIQx when expressed as nanomoles of product formed per minute per nanomoles of P450 1A2. Differences in regioselective oxidation of MeIQx were also observed with human and rat liver microsomes and the respective P450 1A2 orthologs. In contrast to human liver microsomes and P450 1A2, rat liver microsomes and purified rat P4501A2 were unable to catalyze the oxidation of MeIQx to the carboxylic derivative IQx-8-COOH, an important detoxication product formed in humans. However, rat liver microsomes and rat P4501A2, but not human liver microsomes or human P450 1A2, extensively catalyzed ring oxidation at the C-5 position of MeIQx to form the detoxication product 2-amino-3,8-dimethyl-5-hydroxyimidazo[4,5-f]quinoxaline (5-HO-MeIQx). There are important differences between human and rat P450 1A2, both in catalytic activities and oxidation pathways of MeIQx, that may affect the biological activity of this carcinogen and must be considered when assessing human health risk.

  3. Appendicular Skeletal Muscle Mass and Insulin Resistance in an Elderly Korean Population: The Korean Social Life, Health and Aging Project-Health Examination Cohort

    Directory of Open Access Journals (Sweden)

    Seung Won Lee

    2015-02-01

    Full Text Available BackgroundIncreasing evidence supports an association between age-related loss of muscle mass and insulin resistance. However, the association has not been fully investigated in the general population. Thus, we investigated the association between appendicular skeletal muscle mass (ASM and insulin resistance in an elderly Korean population.MethodsThis cross-sectional study included 158 men (mean age, 71.8 and 241 women (mean age, 70.6 from the Korean Social Life, Health and Aging Project, which started in 2011. In this study, ASM was measured by bioelectrical impedance analysis and was analyzed in three forms: ASM (kg, ASM/height2 (kg/m2, and ASM/weight (%. The homeostasis model assessment of insulin resistance (HOMA-IR was used as a measure of insulin resistance. The relationships between the ASM values and the HOMA-IR were investigated by multiple linear regression models.ResultsThe HOMA-IR was positively associated with ASM (β=0.43, P<0.0001 and ASM/height2 (β=0.36, P<0.0001 when adjusted for sex and age. However, after additional adjustment for body weight, HOMA-IR was inversely associated with ASM (β=-0.43, P<0.001 and ASM/height2 (β=-0.30, P=0.001. Adjustment for other potential confounders did not change these associations. Conversely, HOMA-IR was consistently and inversely associated with ASM/weight before and after adjustment for other potential confounders.ConclusionOur results support the idea that lower skeletal muscle mass is independently associated with insulin resistance in older adults. When evaluating sarcopenia or muscle-related conditions in older adults, their whole body sizes also need to be considered.

  4. An Approach to Developing Local Climate Change Environmental Public Health Indicators, Vulnerability Assessments, and Projections of Future Impacts

    OpenAIRE

    Adele Houghton; Paul English

    2014-01-01

    Environmental public health indicators (EPHIs) are used by local, state, and federal health agencies to track the status of environmental hazards; exposure to those hazards; health effects of exposure; and public health interventions designed to reduce or prevent the hazard, exposure, or resulting health effect. Climate and health EPHIs have been developed at the state, federal, and international levels. However, they are also needed at the local level to track variations in community vulnera...

  5. Global emission estimates and radiative impact of C4F10, C5F12, C6F14, C7F16 and C8F18

    Directory of Open Access Journals (Sweden)

    R. G. Prinn

    2012-05-01

    Full Text Available Global emission estimates based on new atmospheric observations are presented for the acylic high molecular weight perfluorocarbons (PFCs: decafluorobutane (C4F10, dodecafluoropentane (C5F12, tetradecafluorohexane (C6F14, hexadecafluoroheptane (C7F16 and octadecafluorooctane (C8F18. Emissions are estimated using a 3-dimensional chemical transport model and an inverse method that includes a growth constraint on emissions. The observations used in the inversion are based on newly measured archived air samples that cover a 39-yr period, from 1973 to 2011, and include 36 Northern Hemispheric and 46 Southern Hemispheric samples (Ivy et al., 2012. The derived emission estimates show that global emission rates were largest in the 1980s and 1990s for C4F10 and C5F12, and in the 1990s for C6F14,C7F16 and C8F18. After a subsequent decline, emissions have remained relatively stable, within 20%, for the last 5 yr. Bottom-up emission estimates are available from the Emission Database for Global Atmospheric Research version 4.2 (EDGARv4.2 for C4F10, C5F12, C6F14 and C7F16, and inventories of C4F10, C5F12 andC6F14 are reported to the United Nations' Framework Convention on Climate Change (UNFCCC by Annex 1 countries that have ratified the Kyoto Protocol. The atmospheric measurement based emission estimates are 20 times larger than EDGARv4.2 for C4F10 and over three orders of magnitude for C5F12. The derived emission estimates for C6F14 largely agree with the bottom-up estimates from EDGARv4.2. Moreover, the C7F16 emission estimates are comparable to those of EDGARv4.2 at their peak in the 1990s, albeit significant underestimation for the other time periods. There are no bottom-up emission estimates for C8F18, thus the emission rates reported here are the first for C8F18. The reported inventories for C4F10, C5F12 and C6F14 to UNFCCC are five to ten times lower than those estimated in this study. In addition, we present measured infrared absorption spectra for C

  6. Rural health care delivery amidst federal retrenchment: lessons from the Robert Wood Johnson Foundation's Rural Practice Project.

    Science.gov (United States)

    Moscovice, I S; Rosenblatt, R A

    1982-12-01

    This paper examines the experience of the Robert Wood Johnson Foundation's Rural Practice Project (RPP), a major non-governmental effort in the last decade concentrating on the direct delivery of rural health services. The nine RPP sites started prior to 1977 showed a slow but steady increase in their utilization levels and improvement in their financial status during their initial operational years. The tempo of their development was remarkably similar to that of federally sponsored practices in underserved rural areas. After four years of operation, all of the practices had completed their period of grant support; the practices survived in all cases, with almost all of the practices still retaining community sponsorship, salaried physicians, and a commitment to comprehensive care. Practices in sparsely populated rural areas and in areas with fewer hospital beds grew more slowly than those set in rural areas with higher population density and more ancillary resources. We conclude that the use of time-limited initial subsidies is an effective strategy in starting new rural practices in underserved areas and that those practices have a good chance of surviving their start-up phase.

  7. Determinants of Cytochrome P450 2C8 Substrate Binding: Structures of Complexes With Montelukast, Troglitazone, Felodipine And 9-CIS-Retinoic Acid

    Energy Technology Data Exchange (ETDEWEB)

    Schoch, G.A.; Yano, J.K.; Dansette, P.M.; Stout, C.D.; Johnson, E.F.

    2009-05-27

    Although a crystal structure and a pharmacophore model are available for cytochrome P450 2C8, the role of protein flexibility and specific ligand-protein interactions that govern substrate binding are poorly understood. X-ray crystal structures of P450 2C8 complexed with montelukast (2.8 {angstrom}), troglitazone (2.7 {angstrom}), felodipine (2.3 {angstrom}), and 9-cis-retinoic acid (2.6 {angstrom}) were determined to examine ligand-protein interactions for these chemically diverse compounds. Montelukast is a relatively large anionic inhibitor that exhibits a tripartite structure and complements the size and shape of the active-site cavity. The inhibitor troglitazone occupies the upper portion of the active-site cavity, leaving a substantial part of the cavity unoccupied. The smaller neutral felodipine molecule is sequestered with its dichlorophenyl group positioned close to the heme iron, and water molecules fill the distal portion of the cavity. The structure of the 9-cis-retinoic acid complex reveals that two substrate molecules bind simultaneously in the active site of P450 2C8. A second molecule of 9-cis-retinoic acid is located above the proximal molecule and can restrain the position of the latter for more efficient oxygenation. Solution binding studies do not discriminate between cooperative and noncooperative models for multiple substrate binding. The complexes with structurally distinct ligands further demonstrate the conformational adaptability of active site-constituting residues, especially Arg-241, that can reorient in the active-site cavity to stabilize a negatively charged functional group and define two spatially distinct binding sites for anionic moieties of substrates.

  8. C-C Bond Formation: Synthesis of C5 Substituted Pyrimidine and C8 Substituted Purine Nucleosides Using Water Soluble Pd-imidate Complex.

    Science.gov (United States)

    Gayakhe, Vijay; Ardhapure, Ajaykumar V; Kapdi, Anant R; Sanghvi, Yogesh S; Serrano, Jose Luis; Schulzke, Carola

    2016-01-01

    The synthesis of a highly efficient, water soluble [Pd(Sacc)2 (TPA)2 ] complex for C-C bond formation is described. Additionally, application of the [Pd(Sacc)2 (TPA)2 ] complex for Suzuki-Miyaura arylation of all four nucleosides (5-iodo-2'-deoxyuridine [5-IdU], 5-iodo-2'-deoxycytidine [5-IdC], 8-bromo-2'-deoxyadenosine, and 8-bromo-2'-deoxyguanosine) with various aryl/heteroaryl boronic acids in plain water under milder conditions is demonstrated. © 2016 by John Wiley & Sons, Inc. PMID:27248782

  9. Total synthesis of (+)-discodermolide: an improved endgame exploiting a Still-Gennari-type olefination with a C1-C8 beta-ketophosphonate fragment.

    Science.gov (United States)

    Paterson, Ian; Lyothier, Isabelle

    2004-12-23

    [structure: see text] An improved, third-generation, total synthesis of (+)-discodermolide, a potent microtubule-stabilizing anticancer agent of marine sponge origin, is achieved in 11.1% yield over 21 steps. Key steps include a Still-Gennari HWE olefination, performed using NaH as the base, between C1-C8 beta-ketophosphonate 7 and C9-C24 aldehyde 8, introducing the (8Z)-alkene with 10:1 selectivity, and K-Selectride reduction of the derived enone 16, installing the (7S)-configuration.

  10. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C8H10 1,4-Dimethylbenzene (VMSD1511, LB4830_V)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C8H10 1,4-Dimethylbenzene (VMSD1511, LB4830_V)' providing data from direct measurement of low-pressure thermodynamic speed of sound at variable mole fraction and constant temperature, in the single-phase region(s).

  11. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C8H10 1,4-Dimethylbenzene (VMSD1212, LB4825_V)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C8H10 1,4-Dimethylbenzene (VMSD1212, LB4825_V)' providing data by calculation of molar excess volume from low-pressure density measurements at variable mole fraction and constant temperature.

  12. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C8H10 1,4-Dimethylbenzene (VMSD1111, LB4821_V)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C8H10 1,4-Dimethylbenzene (VMSD1111, LB4821_V)' providing data from direct low-pressure measurement of mass density at variable mole fraction and constant temperature, in the single-phase region(s).

  13. A MODEL OF PARTNERSHIP PROJECT FOR HEALTH AND COMMUNITY DEVELOPMENT BETWEEN UNIVERSITY OF PITESTI AND A RURAL POPULATION, FROM A DISADVANTAGED GEOGRAPHICAL AREA

    Directory of Open Access Journals (Sweden)

    Constantin Ciucurel

    2016-07-01

    Full Text Available The purpose of this project aimed to apply a sanogenetic intervention on a rural population, from a disadvantaged geographical area. 50 students in Physical Therapy and 4 teachers were involved in assessment and intervention activities for optimization of the individual and collective health status of inhabitants of a village located in the Caras-Severin district, in the Cerna Mountains. The project results consisted in: a database regarding the health of the subjects; a model of therapeutic education and promoting of a healthy lifestyle among inhabitants; creating a network of social interaction among project participants; professional and transversal skills development of students; developing research skills of teachers. The activities referred to: subjects health assessment (medical diagnostic, anthropometric and physiometric measurements; recommending and implementing of programs of kinetic prophylaxis and rehabilitation; conducting activities to provide opportunities for social interaction and support. The project offered also the possibility of optimizing the students training by developing their professional skills of assessment and physiotherapeutic intervention, their transversal skills of teamwork, respect for the principles for professional ethics and self-assessment of needs for professional training and also for developing good inter-institutional relations, designed to facilitate the development of specific research activities, in benefit of both parts.

  14. Health System Measurement Project

    Science.gov (United States)

    ... reason, "innovation" is a key word throughout the pharmaceutical industry and the healthcare community. Slide number 4 Mean ... reason, "innovation" is a key word throughout the pharmaceutical industry and the healthcare community. More Mean Total Premium ...

  15. Lunar Health Monitor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Orbital Research has successfully demonstrated a dry electrode (no electrolyte or gel required) for heart rate and ECG monitoring. Preliminary data has indicated...

  16. Synthesis, crystal structure and electrical properties of N,N-dimethylanilinium trichloridostannate (II): (C8H12N)SnCl3

    Science.gov (United States)

    Chouaib, H.; Kamoun, S.; Costa, L. C.; Graça, M. P. F.

    2015-12-01

    A new (C8H12N)SnCl3 crystal of the general formula AMX3 was grown by soft chemistry method. X-ray study shows that the crystal crystallized in a monoclinic system with the space group P21/a. The structure was solved by Patterson method and refined to a final value of R = 0.0304 for 1157 independent observed reflections. The cohesion and the stability of the atomic arrangement result from the N-H … Cl hydrogen bonds between (C8H12N)+ cations and isolated (SnCl3)- anions. At high temperature this compound exhibits a structural phase transition at 340 K. This transition has been characterized by differential scanning calorimetric and impedance spectroscopy. The impedance data were well fitted to an Rp//CPE equivalent electrical circuit model. The close values of activation energies, obtained from the thermal behavior of the conductivity and the relaxation time confirm the presence of a hopping transport mechanism.

  17. The Los Angeles County Community Disaster Resilience Project — A Community-Level, Public Health Initiative to Build Community Disaster Resilience

    Directory of Open Access Journals (Sweden)

    David Eisenman

    2014-08-01

    Full Text Available Public health officials need evidence-based methods for improving community disaster resilience and strategies for measuring results. This methods paper describes how one public health department is addressing this problem. This paper provides a detailed description of the theoretical rationale, intervention design and novel evaluation of the Los Angeles County Community Disaster Resilience Project (LACCDR, a public health program for increasing community disaster resilience. The LACCDR Project utilizes a pretest–posttest method with control group design. Sixteen communities in Los Angeles County were selected and randomly assigned to the experimental community resilience group or the comparison group. Community coalitions in the experimental group receive training from a public health nurse trained in community resilience in a toolkit developed for the project. The toolkit is grounded in theory and uses multiple components to address education, community engagement, community and individual self-sufficiency, and partnerships among community organizations and governmental agencies. The comparison communities receive training in traditional disaster preparedness topics of disaster supplies and emergency communication plans. Outcome indicators include longitudinal changes in inter-organizational linkages among community organizations, community member responses in table-top exercises, and changes in household level community resilience behaviors and attitudes. The LACCDR Project is a significant opportunity and effort to operationalize and meaningfully measure factors and strategies to increase community resilience. This paper is intended to provide public health and academic researchers with new tools to conduct their community resilience programs and evaluation research. Results are not yet available and will be presented in future reports.

  18. Scale-up of community-based malaria control can be achieved without degrading community health workers' service quality: the Village Malaria Worker project in Cambodia

    Directory of Open Access Journals (Sweden)

    Yasuoka Junko

    2012-01-01

    Full Text Available Abstract Background Malaria control has been scaled up in many developing countries in their efforts to achieve the Millennium Development Goals. Cambodia recently scaled up their Village Malaria Worker (VMW project by substantially increasing the number of VMWs and expanding the project's health services to include treatment of fever, diarrhoea, and Acute Respiratory Infections (ARI in children under five. This study examined if the scale-up interfered with VMWs' service quality, actions, and knowledge of malaria control, and analysed VMWs' overall achievements and perceptions of the newly added health services. Methods Structured interviews were conducted pre scale-up in February-March 2008 with 251 VMWs and post scale-up in July-August 2010 with 252 VMWs. Comparing the pre and post scale-up survey results (n = 195, changes were examined in terms of VMWs' 1 service quality, 2 malaria prevention and vector control actions, and 3 knowledge of malaria epidemiology and vector ecology. In addition, VMWs' newly added health services were descriptively analysed based on the post scale-up survey (n = 252. Results VMWs' service quality and actions significantly improved overall during the scale-up of the VMW project (mean index score: +0.805, p p p Conclusions The Cambodian experience clearly demonstrated that a nationwide scale-up of community-based malaria control can be achieved without degrading community health workers' service quality. The government's strategy to expand VMWs' health services, while providing sufficient training to maintain the quality of their original malaria control services, could have contributed to the improvement of VMW's service quality, actions, and knowledge in spite of the rapid scale-up of the project.

  19. Thyroid cancer in Belarus after Chernobyl: International thyroid project. International Programme on the Health Effects of the Chernobyl Accident

    International Nuclear Information System (INIS)

    The Chernobyl accident has demonstrated what was always known but perhaps has not been as fully acknowledged as it might, namely that national or other geographical boundaries are no defence against radioactive fallout. Much (some 2.2 millions) of the approximately 10 million population of Belarus have been, and are still being, exposed to the radiation resulting from the accident. The most obvious adverse effect of the radiation is on the condition of the thyroid system in children. Now, only just over eight years after the accident, we are experiencing an increase in childhood thyroid cancer which is particularly marked in those closest to the site of the accident. In young children thyroid cancer is an extremely rare condition and thus although at present the numbers of cases (more than 250 since the accident) is not large in absolute terms it is a sufficiently important development to capture the interest of the international medical and scientific community and to give rise to considerable apprehension as to the future development of the outbreak. Although this increase in thyroid cancer has not been definitively attributed to the Chernobyl accident, and indeed a major aim of this project is to elucidate the cause of the cancer, the fact of the exposure of the population of Belarus to the isotopes of iodine at the time of accident, and what we have learned from the experience in the Marshall Islands following the testing of the first hydrogen bomb on Bikini Atoll lead us to consider the accident as the most likely cause of the increase. Belarus is a relatively small and newly independent country. By any standards the Chernobyl accident was a technological disaster of enormous proportions causing damage to the environment over vast land areas. Necessarily it must be a major concern for us and an issue to be considered in the planning of our future. Its impact on the future health of our nation must be assessed as objectively and dispassionately as possible and

  20. Understanding Leisure-related Program Effects by Using Process Data in the HealthWise South Africa Project.

    Science.gov (United States)

    Caldwell, Linda L; Younker, Anita S; Wegner, Lisa; Patrick, Megan E; Vergnani, Tania; Smith, Edward A; Flisher, Alan J

    2008-01-01

    As the push for evidence-based programming gathers momentum, many human services programs and interventions are under increased scrutiny to justify their effectiveness across different conditions and populations. Government agencies and the public want to be assured that their resources are being put to good use on programs that are effective and efficient (Guskey, 2000). Thus, programs are increasingly based on theory and evaluated through randomized control trials using longitudinal data. Despite this progress, hypothesized outcomes are often not detected and/or their effect sizes are small (Gingiss, Roberts-Gray, Boerm, 2006). Moreover, findings may go against intuition or "gut feelings" on the part of project staff. Given the need to understand how program implementation issues relate to outcomes, this study focuses on whether process measures that focus on program implementation and fidelity can shed light on associated outcomes. In particular, we linked the process evaluation of the HealthWise motivation lesson with outcomes across four waves of data collection. We hypothesized that HealthWise would increase learners' intrinsic and identified forms of motivation, and decrease amotivation and extrinsic motivation. We did not hypothesize a direction of effects on introjected motivation due to its conceptual ambiguity. Data came from youth in four intervention schools (n = 902, 41.1%) and five control schools (n = 1291, 58.9%) who were participating in a multi-cohort, longitudinal study. The schools were in a township near Cape Town, South Africa. For each cohort, baseline data are collected on learners as they begin Grade 8. We currently have four waves of data collected on the first cohort, which is the focus of this paper. The mean age of the sample at Wave 3 was 15.0 years (SD = .86) and 51% of students were female. Results suggested that there was evidence of an overall program effect of the curriculum on amotivation regardless of fidelity of implementation