WorldWideScience

Sample records for c6 microprocessor applications

  1. Microprocessors principles and applications

    Debenham, Michael J

    1979-01-01

    Microprocessors: Principles and Applications deals with the principles and applications of microprocessors and covers topics ranging from computer architecture and programmed machines to microprocessor programming, support systems and software, and system design. A number of microprocessor applications are considered, including data processing, process control, and telephone switching. This book is comprised of 10 chapters and begins with a historical overview of computers and computing, followed by a discussion on computer architecture and programmed machines, paying particular attention to t

  2. Energy conservation applications of microprocessors

    Shih, James Y.

    1979-07-01

    A survey of the application of microprocessors for industrial and commercial energy conservation has been made. Microprocessor applications for HVAC, chiller control, and automotive equipment are discussed. A case study of successful replacement of a conventional cooling plant control is recounted. The rapid advancement of microelectronic technology will affect efficient energy control, more sophisticated control methodology, and more investment in controls.

  3. Microprocessors

    Cornillie, O A R

    1985-01-01

    Microprocessors presents an overview of the state of the art in the field of microprocessors and illustrates, with the aid of patents, its utilization and application. Organized into six parts, the book begins with an introduction to the microprocessor, microcomputer, and software. Parts I-III focus on program control, digital control, and electrical motor control. Subsequent parts show the medical applications, measuring instruments, and treatment of data in microprocessors.

  4. Microprocessors applications in the nuclear industry

    Ethridge, C.D.

    1980-01-01

    Microprocessors in the nuclear industry, particularly at the Los Alamos Scientific Laboratory, have been and are being utilized in a wide variety of applications ranging from data acquisition and control for basic physics research to monitoring special nuclear material in long-term storage. Microprocessor systems have been developed to support weapons diagnostics measurements during underground weapons testing at the Nevada Test Site. Multiple single-component microcomputers are now controlling the measurement and recording of nuclear reactor operating power levels. The CMOS microprocessor data-acquisition instrumentation has operated on balloon flights to monitor power plant emissions. Target chamber mirror-positioning equipment for laser fusion facilities employs microprocessors

  5. A Fault-tolerant RISC Microprocessor for Spacecraft Applications

    Timoc, Constantin; Benz, Harry

    1990-01-01

    Viewgraphs on a fault-tolerant RISC microprocessor for spacecraft applications are presented. Topics covered include: reduced instruction set computer; fault tolerant registers; fault tolerant ALU; and double rail CMOS logic.

  6. Application of microprocessors to radiation protection measurements

    Zappe, D.; Meldes, C.

    1982-01-01

    In radiation protection measurements signals from radiation detectors or dosemeters have to be transformed into quantities relevant to radiation protection. In most cases this can only be done by taking into account various parameters (e.g. the quality factor). Moreover, the characteristics of the statistical laws of nuclear radiation emission have to be considered. These problems can properly be solved by microprocessors. After reviewing the main properties of microprocessors, some typical examples of applying them to problems of radiation protection measurement are given. (author)

  7. Auxiliary/Master microprocessor CAMAC Crate Controller applications

    Barsotti, E.

    1975-01-01

    The need for further sophistication of an already complex serial CAMAC control system at Fermilab led to the development of an Auxilary/Master CAMAC Crate Controller. The controller contains a Motorola 6800 microprocessor, 2K bytes of RAM, and 8K bytes of PROM memory. Bussed dataway lines are time shared with CAMAC signals to provide memory expansion and direct addressing of peripheral devices without the need of external cabling. The Auxiliary/Master Crate Controller (A/MCC) can function as either a Master, i.e., stand alone, crate controller or as an Auxiliary controller to Fermilab's Serial Crate Controller (SCC). Two modules, one single- and one double-width, make up an A/MCC. The microprocessor has one nonmaskable and one maskable vectored interrupt. Time sharing the dataway between SCC programmed and block transfer generated dataway cycles and A/MCC operations still allows a 99 percent microprocessor CPU busy time. Since the conception of the A/MCC, there has been an increasing number of control system-related projects proposed which would not have been possible or would have been very difficult to implement without such a device. The first such application now in use at Fermilab is a stand-alone control system for a mass spectrometer experiment in the Main Ring Internal Target Area. This application in addition to other proposed A/MCC applications, both stand-alone and auxiliary, is discussed

  8. G-cueing microcontroller (a microprocessor application in simulators)

    Horattas, C. G.

    1980-01-01

    A g cueing microcontroller is described which consists of a tandem pair of microprocessors, dedicated to the task of simulating pilot sensed cues caused by gravity effects. This task includes execution of a g cueing model which drives actuators that alter the configuration of the pilot's seat. The g cueing microcontroller receives acceleration commands from the aerodynamics model in the main computer and creates the stimuli that produce physical acceleration effects of the aircraft seat on the pilots anatomy. One of the two microprocessors is a fixed instruction processor that performs all control and interface functions. The other, a specially designed bipolar bit slice microprocessor, is a microprogrammable processor dedicated to all arithmetic operations. The two processors communicate with each other by a shared memory. The g cueing microcontroller contains its own dedicated I/O conversion modules for interface with the seat actuators and controls, and a DMA controller for interfacing with the simulation computer. Any application which can be microcoded within the available memory, the available real time and the available I/O channels, could be implemented in the same controller.

  9. Microprocessor Controlled Maximum Power Point Tracker for Photovoltaic Application

    Jiya, J. D.; Tahirou, G.

    2002-01-01

    This paper presents a microprocessor controlled maximum power point tracker for photovoltaic module. Input current and voltage are measured and multiplied within the microprocessor, which contains an algorithm to seek the maximum power point. The duly cycle of the DC-DC converter, at which the maximum power occurs is obtained, noted and adjusted. The microprocessor constantly seeks for improvement of obtained power by varying the duty cycle

  10. A Fourier transform with speed improvements for microprocessor applications

    Lokerson, D. C.; Rochelle, R.

    1980-01-01

    A fast Fourier transform algorithm for the RCA 1802microprocessor was developed for spacecraft instrument applications. The computations were tailored for the restrictions an eight bit machine imposes. The algorithm incorporates some aspects of Walsh function sequency to improve operational speed. This method uses a register to add a value proportional to the period of the band being processed before each computation is to be considered. If the result overflows into the DF register, the data sample is used in computation; otherwise computation is skipped. This operation is repeated for each of the 64 data samples. This technique is used for both sine and cosine portions of the computation. The processing uses eight bit data, but because of the many computations that can increase the size of the coefficient, floating point form is used. A method to reduce the alias problem in the lower bands is also described.

  11. Application of a microprocessor system to stream monitoring

    Oakes, T.W.; Shank, K.E.

    1978-01-01

    Low-level liquid wastes originating from the Oak Ridge National Laboratory (ORNL) are discharged, after treatment, into White Oak Creek, which is a small tributary of the Clinch River located in East Tennessee. Samples of White Oak Creek discharges are collected at White Oak Dam by a continuous digital proportional water sampler and analyzed weekly for radioactivity. The sampler contains a control system with a microprocessor that has been programmed to solve nonlinear weir equations. This system was designed and installed at ORNL by the Instrumentation and Controls Division and was tested by the Environmental Surveillance and Evaluation Section of the Industrial Safety and Applied Health Physics Division. The control system was designed to measure water flow rates from 0 to 334 ft 3 /sec to within 0.1%. Results of our test program and possible applications to other liquid sampling needs are discussed

  12. An SEU rate prediction method for microprocessors of space applications

    Gao Jie; Li Qiang

    2012-01-01

    In this article,the relationship between static SEU (Single Event Upset) rate and dynamic SEU rate in microprocessors for satellites is studied by using process duty cycle concept and fault injection technique. The results are compared to in-orbit flight monitoring data. The results show that dynamic SEU rate by using process duty cycle can estimate in-orbit SEU rate of microprocessor reasonable; and the fault injection technique is a workable method to estimate SEU rate. (authors)

  13. Application of microprocessor based controller in the Breeder Reactor Program

    Messick, N.C.; Lukas, M.P.

    1985-01-01

    This paper treats Argonne National Laboratory's experience using microprocessor based controllers presently in use on several control loops within the EBR-II reactor facility as well as tests being performed by these controllers. Also included is a discussion of the expandability, modularity, range of capabilities and higher level functions possible using such equipment

  14. Applications of microprocessors in upgrading of accelerator controls

    Mallory, K.B.

    1977-03-01

    Experience at SLAC demonstrates that the criteria for selection and use of microprocessors in modifying an existing control system may differ from the criteria that apply during installation of the control system of a new accelerator. Considerations such as cost of individual projects, progressive installation without disruption of operations and training of on-board personnel can outweigh ''obvious'' goals such as standardization of hardware, uniformity of software, or even a rigid specification of link protocols with the main computer system

  15. Application of a 16-bit microprocessor to the digital control of machine tools

    Issaly, Alain

    1979-01-01

    After an overview of machine tools (various types, definition standardization, associated technologies for motors and position sensors), this research thesis describes the principles of computer-based digital control: classification of machine tool command systems, machining programming, programming languages, dialog function, interpolation function, servo-control function, tool compensation function. The author reports the application of a 16-bit microprocessor to the computer-based digital control of a machine tool: feasibility, selection of microprocessor, hardware presentation, software development and description, machining mode, translation-loading mode

  16. Microprocessor interfacing

    Vears, R E

    2014-01-01

    Microprocessor Interfacing provides the coverage of the Business and Technician Education Council level NIII unit in Microprocessor Interfacing (syllabus U86/335). Composed of seven chapters, the book explains the foundation in microprocessor interfacing techniques in hardware and software that can be used for problem identification and solving. The book focuses on the 6502, Z80, and 6800/02 microprocessor families. The technique starts with signal conditioning, filtering, and cleaning before the signal can be processed. The signal conversion, from analog to digital or vice versa, is expl

  17. The microprocessor boom

    Anon.

    1979-01-01

    The applications of microprocessors in high energy physics experiments are discussed. Many benefits are predicted for data acquisition and handling systems and for control and monitoring functions. (W.D.L.).

  18. Microprocessor engineering

    Holdsworth, B

    2013-01-01

    Microprocessor Engineering provides an insight in the structures and operating techniques of a small computer. The book is comprised of 10 chapters that deal with the various aspects of computing. The first two chapters tackle the basic arithmetic and logic processes. The third chapter covers the various memory devices, both ROM and RWM. Next, the book deals with the general architecture of microprocessor. The succeeding three chapters discuss the software aspects of machine operation, while the last remaining three chapters talk about the relationship of the microprocessor with the outside wo

  19. Microprocessor hardware reliability

    Wright, R I

    1982-01-01

    Microprocessor-based technology has had an impact in nearly every area of industrial electronics and many applications have important safety implications. Microprocessors are being used for the monitoring and control of hazardous processes in the chemical, oil and power generation industries, for the control and instrumentation of aircraft and other transport systems and for the control of industrial machinery. Even in the field of nuclear reactor protection, where designers are particularly conservative, microprocessors are used to implement certain safety functions and may play increasingly important roles in protection systems in the future. Where microprocessors are simply replacing conventional hard-wired control and instrumentation systems no new hazards are created by their use. In the field of robotics, however, the microprocessor has opened up a totally new technology and with it has created possible new and as yet unknown hazards. The paper discusses some of the design and manufacturing techniques which may be used to enhance the reliability of microprocessor based systems and examines the available reliability data on lsi/vlsi microcircuits. 12 references.

  20. Application of multiwall carbon nanotubes for thermal dissipation in a micro-processor

    Bui Hung Thang; Phan Ngoc Hong; Phan Hong Khoi; Phan Ngoc Minh [Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi (Viet Nam)], E-mail: minhpn@ims.vast.ac.vn

    2009-09-01

    One of the most valuable properties of the carbon nanotubes materials is its high thermal conductivity with 2000 W/m.K (compared to thermal conductivity of Ag 419 W/m.K). It suggested an approach in applying the CNTs in thermal dissipation media to improve the performance of computer processors and other high power electronic devices. In this research, the multiwall carbon nanotubes (MWCNTs) made by thermal chemical vapour deposition (CVD) at our laboratory was employed as the heat dissipation media in a microprocessor a Personal Computer with configuration: Intel Pentium IV 3.066 GHz, 512Mb of RAM and Windows XP Service Pack 2 Operating System. We directly measured the temperature of the microprocessor during the operation of the computer in two modes: 100% usage CPU mode and over-clocking mode. The measured results showed that when using our thermal dissipation media (a mixture of the mentioned commercial thermal compound and 2 wt.%. MWCNTs), the temperature of the microprocessor decreased 5 deg. C, and the time for increasing the temperature of the microprocessor was three times longer than that when using commercial thermal compound. In over-clocking mode, the processor speed reached 3.8 GHz with 165 MHz of system bus clock speed; it was 1.24 times higher than that in non over-clocking mode. The results confirmed a promising way of using MWCNTs as the thermal dissipation media for microprocessor and high power electronic devices.

  1. Application of multiwall carbon nanotubes for thermal dissipation in a micro-processor

    Thang, Bui Hung; Hong, Phan Ngoc; Khoi, Phan Hong; Minh, Phan Ngoc

    2009-09-01

    One of the most valuable properties of the carbon nanotubes materials is its high thermal conductivity with 2000 W/m.K (compared to thermal conductivity of Ag 419 W/m.K). It suggested an approach in applying the CNTs in thermal dissipation media to improve the performance of computer processors and other high power electronic devices. In this research, the multiwall carbon nanotubes (MWCNTs) made by thermal chemical vapour deposition (CVD) at our laboratory was employed as the heat dissipation media in a microprocessor a Personal Computer with configuration: Intel Pentium IV 3.066 GHz, 512Mb of RAM and Windows XP Service Pack 2 Operating System. We directly measured the temperature of the microprocessor during the operation of the computer in two modes: 100% usage CPU mode and over-clocking mode. The measured results showed that when using our thermal dissipation media (a mixture of the mentioned commercial thermal compound and 2 wt.%. MWCNTs), the temperature of the microprocessor decreased 5°C, and the time for increasing the temperature of the microprocessor was three times longer than that when using commercial thermal compound. In over-clocking mode, the processor speed reached 3.8 GHz with 165 MHz of system bus clock speed; it was 1.24 times higher than that in non over-clocking mode. The results confirmed a promising way of using MWCNTs as the thermal dissipation media for microprocessor and high power electronic devices.

  2. Application of multiwall carbon nanotubes for thermal dissipation in a micro-processor

    Bui Hung Thang; Phan Ngoc Hong; Phan Hong Khoi; Phan Ngoc Minh

    2009-01-01

    One of the most valuable properties of the carbon nanotubes materials is its high thermal conductivity with 2000 W/m.K (compared to thermal conductivity of Ag 419 W/m.K). It suggested an approach in applying the CNTs in thermal dissipation media to improve the performance of computer processors and other high power electronic devices. In this research, the multiwall carbon nanotubes (MWCNTs) made by thermal chemical vapour deposition (CVD) at our laboratory was employed as the heat dissipation media in a microprocessor a Personal Computer with configuration: Intel Pentium IV 3.066 GHz, 512Mb of RAM and Windows XP Service Pack 2 Operating System. We directly measured the temperature of the microprocessor during the operation of the computer in two modes: 100% usage CPU mode and over-clocking mode. The measured results showed that when using our thermal dissipation media (a mixture of the mentioned commercial thermal compound and 2 wt.%. MWCNTs), the temperature of the microprocessor decreased 5 deg. C, and the time for increasing the temperature of the microprocessor was three times longer than that when using commercial thermal compound. In over-clocking mode, the processor speed reached 3.8 GHz with 165 MHz of system bus clock speed; it was 1.24 times higher than that in non over-clocking mode. The results confirmed a promising way of using MWCNTs as the thermal dissipation media for microprocessor and high power electronic devices.

  3. Microprocessors in automatic chemical analysis

    Goujon de Beauvivier, M.; Perez, J.-J.

    1979-01-01

    Application of microprocessors to programming and computing of solutions chemical analysis by a sequential technique is examined. Safety, performances reliability are compared to other methods. An example is given on uranium titration by spectrophotometry [fr

  4. Microprocessor based techniques at CESR

    Giannini, G.; Cornell Univ., Ithaca, NY

    1981-01-01

    Microprocessor based systems succesfully used in connection with the High Energy Physics experimental program at the Cornell Electron Storage Ring are described. The multiprocessor calibration system for the CUSB calorimeter is analyzed in view of present and future applications. (orig.)

  5. Sectional microprocessor based microcomputer and its application to express analysis using interactive language

    Lang, I.; Leveleki, L.; Salai, M.; Turani, D.

    1984-01-01

    Sectional microprocessor TPA-L/128H based mini-computer being a part of the TPA-8 computer family is developed. A substantial increase of the computer operation rate is attained at the expense of microprogram monitoring. The central processor is constructed on the base of the AM2900 sectional microprocessor elements. The TPA-L/128H computer is program compatible with TPA-8 computer, perfectly equipped with software: high level languages as well as OS/L, COS/H, RTS/H, PAL/128, WPS, TEASYS-8 and IL 128 ensuring statistical data processing, physical experiments automation and interactive experimental data processing. The real time basis problems and CAMAC devices monitoring are efficiently solved

  6. Recent applications of microprocessor-based instruments in nuclear power stations

    Cash, N.R.; Dennis, U.E.

    1988-01-01

    The incorporation of microprocessors in the design of nuclear power plant instrumentation has led to levels of measurement and control not available previously. In addition to the expected expansion of functional (system) capability, numerous desirable features now are possible. The added ability to both self-calibrate and perform compensation algorithms has led to dramatic improvements in accuracies, response times, and noise rejection. Automated performance checking and self-testing simplify troubleshooting and required periodic surveillance. Alphanumeric displays allow both menu-driven operation and user-prompting, which, in turn, contribute to mistake avoidance. New features of these microprocessor-based instruments are of specific benefit in nuclear power reactors, were safety is of prime concern. Greater reliability and accuracy can be provided. Shortened calibration, surveillance, and repair times reduce the exposure to unnecessary challenges of the plant's protection systems that can arise from spurious noise signals

  7. Application of Microprocessor-Based Equipment in Nuclear Power Plants - Technical Basis for a Qualification Methodology

    Korsah, K.

    2001-01-01

    This document (1) summarizes the most significant findings of the ''Qualification of Advanced Instrumentation and Control (I and C) Systems'' program initiated by the Nuclear Regulatory Commission (NRC); (2) documents a comparative analysis of U.S. and European qualification standards; and (3) provides recommendations for enhancing regulatory guidance for environmental qualification of microprocessor-based safety-related systems. Safety-related I and C system upgrades of present-day nuclear power plants, as well as I and C systems of Advanced Light-Water Reactors (ALWRs), are expected to make increasing use of microprocessor-based technology. The Nuclear Regulatory Commission (NRC) recognized that the use of such technology may pose environmental qualification challenges different from current, analog-based I and C systems. Hence, it initiated the ''Qualification of Advanced Instrumentation and Control Systems'' program. The objectives of this confirmatory research project are to (1) identify any unique environmental-stress-related failure modes posed by digital technologies and their potential impact on the safety systems and (2) develop the technical basis for regulatory guidance using these findings. Previous findings from this study have been documented in several technical reports. This final report in the series documents a comparative analysis of two environmental qualification standards--Institute of Electrical and Electronics Engineers (IEEE) Std 323-1983 and International Electrotechnical Commission (IEC) 60780 (1998)--and provides recommendations for environmental qualification of microprocessor-based systems based on this analysis as well as on the findings documented in the previous reports. The two standards were chosen for this analysis because IEEE 323 is the standard used in the U.S. for the qualification of safety-related equipment in nuclear power plants, and IEC 60780 is its European counterpart. In addition, the IEC document was published in

  8. Microprocessorized message multiplexer

    Ejzman, S.; Guglielmi, L.; Jaeger, J.J.

    1980-07-01

    The 'Microprocessorized Message Multiplexer' is an elementary development tool used to create and debug the software of a target microprocessor (User Module: UM). It connects together four devices: a terminal, a cassette recorder, the target microprocessor and a host computer where macro and editor for the M 6800 microprocessor are resident [fr

  9. Microprocessorized NMR measurement

    Rijllart, A.

    1984-01-01

    An MC68000 CAMAC microprocessor system for fast and accurate NMR signal measurement will be presented. A stand-alone CAMAC microprocessor system (MC68000 STAC) with a special purpose interface sweeps a digital frequency synthesizer and digitizes the NMR signal with a 16-bit ADC of 17 μs conversion time. It averages the NMR signal data over many sweeps and then transfers it through CAMAC to a computer for calculation of the signal parameters. The computer has full software control over the timing and sweep settings of this signal averager, and thus allows optimization of noise suppression. Several of these processor systems can be installed in the same crate for parallel processing, and the flexibility of the STAC also allows easy adaptation to other applications such as transient recording or phase-sensitive detection. (orig.)

  10. Process control by microprocessors

    Arndt, W [ed.

    1978-12-01

    Papers from the workshop Process Control by Microprocessors being organized by the Karlsruhe Nuclear Research Center, Project PDV, together with the VDI/VDE-Gesellschaft fuer Mess- und Regelungstechnik are presented. The workshop was held on December 13 and 14, 1978 at the facilities of the Nuclear Research Center. The papers are arranged according to the topics of the workshop; one chapter deals with today's state of the art of microprocessor hardware and software technology; 5 chapters are dedicated to applications. The report also contains papers which will not be presented at the workshop. Both the workshop and the report are expected to improve and distribute the know-how about this modern technology.

  11. A microprocessor based exchange data collection and analysis terminal application to A.E.A. PABX

    Mohammed, F.A.; Ezzat, A.K.; Ayad, N.M.A.

    1978-01-01

    The traffic data acquisition and analysis comprises micro-processer based data collection, terminals (MBDCT) and a centralized computer. The MBDCT's can communicate with the computer through a data set system. Each (MBDCT) remote terminal is connected to about two hundreds subscriber lines. It scans the trunk lines to detect the on/off hook states and to calculate the call time and the called number. If the called subscriber is not from the 200 local lines, its status should be detected though the computer communication with the two terminals. The data collected by the terminal can be slightly analysed using the microprocessor programming capability. More-over short quality performance reports can be printed on a printer interfaced to the microprocessor. Also, data can be transmitted to the central computer for further data traffic investigation. The analysis outcome can be utilized for telephone line maintenance and reorganization. This report is concerned with the terminal details as applied to the A-E-A. PABX. It consists mainly of five external lines and about 300 internal lines

  12. Contribution to the automatic command in robotics - Application to the command by microprocessors of the articulated systems

    Al Mouhamed, Mayez

    1982-01-01

    The first part of the present paper deals with the main methods of changing the coordinates for a general articulated system. After a definition of the coordinates changing, we propose a coordination system designed for easy programming of the movements. Its characteristic is to permit the action anywhere on the manipulated object. The second part deals with the force regulation problem. For this purpose we have developed a general force sensor. The informations delivered by the sensor are used by force regulators which are intended for the automatic assembly of subsystems. In the third part the dynamic problem of the articulated systems is exposed. We present a new method which allows to determine dynamic parameters from appropriate motions of the robot. These parameters are then used to implement the dynamic control. Several applications, using the powerful microprocessor INTEL 8086 and its arithmetic coprocessor 8087, are presented, in order to demonstrate the performances gained. (author) [fr

  13. Microprocessors in detectors and analysis

    Siskind, E.J.

    1982-01-01

    The increasing need in high energy physics experiments for computation power for both online and offline applications, coupled with the current microprocessor revolution, has led to the examination of the use of microprocessors in various aspects of HEP computing. A brief (and admittedly somewhat biased) review is given of current hardware products, the costs of developing and producing hardware systems, and the costs of providing appropriate software support tools which allow one to make effective use of physicists' time, and the applicability of certain systems to the various needs of HEP computing

  14. Microprocessors in detectors and analysis

    Siskind, E.J.

    1982-01-01

    The increasing need in high energy physics experiments for computation power for both online and offline applications, coupled with the current microprocessor revolution, has led us to examine the use of microprocessors in various aspects of HEP computing. The following article is a brief (and admittedly somewhat biased) review of current hardware products, the costs of developing and producing hardware systems, and the costs of providing appropriate software support tools which allow one to make effective use of physicists' time, and the applicability of certain systems to the various needs of HEP computing

  15. TRIESTE: College on Microprocessors

    Anon.

    1981-01-01

    The International Centre for Theoretical Physics, set up at Trieste in 1964, has as its major task the provision of a stimulating intellectual environment for physicists from developing countries. This goal is furthered by a varied programme of courses for visiting scientists. Not all the courses remain in the rarefied atmosphere of theory and in September a very successful 'College on Microprocessors: Technology and Applications in Physics' was held. It was a prime example of the efforts being made to spread important modern technology into the developing countries

  16. Mol 7C/6

    Aberle, J.; Schleisiek, K.; Schmuck, I.; Schmidt, L.; Romer, O.; Weih, G.

    1995-01-01

    The Mol 7C/6 coolant blockage experiment in the Belgian BR2 reactor yielded results different from Mol 7C experiments with low burnup pins: At 10% burnup local failure is not self-limiting, but requires active systems for detection and scram. The Mol 7C series was finished in 1991. In each of the test bundles Mol 7C/4, /5 and /6, 30 Mk I pins pre-irradiated in KNK II were used. The central blockage consisted of enriched UO 2 covering 30 percent of the bundle cross-section, with a height of 40 mm. The most important system for timely detection of coolant blockages of the type studied in Mol 7C/6 is based on DND. (orig.)

  17. Application of C_6_0, C_7_2 and carbon nanotubes as anode for lithium-ion batteries: A DFT study

    Najafi, Meysam

    2017-01-01

    The application of C_6_0, C_7_2, CNT (8, 0) and CNT (10, 0) as anode materials for Lithium-ion batteries were investigated by density functional theory (DFT) calculations. Results show that the average values of voltage cell (V_c_e_l_l) and adsorption energy (E_a_d) of CNT (8, 0) and CNT (10, 0) were higher than C_6_0 and C_7_2 ca 0.327 V and 6.52 kcal/mol, respectively. The NH_2 functionalization of studied nanostructures as a strategy to improve the performance of these systems as anode materials of Lithium-ion batteries were investigated. Results show that, NH_2 functionalization of studied nanostructures increase the average values of voltage cell and adsorption energy ca 0.197 V and 8.20 kcal/mol, respectively. Obtained results propose that NH_2 functionalized C_7_2 and CNT (10, 0) have larger V_c_e_l_l and E_a_d values and therefore these nanostructures have higher potential as anode material for Lithium-ion battery. - Highlights: • C_6_0 and CNT (10, 0) as anode materials for Lithium-ion batteries were investigated. • V_c_e_l_l and E_a_d of CNT (8, 0) and CNT (10, 0) were higher than C_6_0 and C_7_2 ca. • NH_2 functionalization of C_6_0 improve the performance of it as anode materials of Lithium-ion batteries.

  18. Small Microprocessor for ASIC or FPGA Implementation

    Kleyner, Igor; Katz, Richard; Blair-Smith, Hugh

    2011-01-01

    A small microprocessor, suitable for use in applications in which high reliability is required, was designed to be implemented in either an application-specific integrated circuit (ASIC) or a field-programmable gate array (FPGA). The design is based on commercial microprocessor architecture, making it possible to use available software development tools and thereby to implement the microprocessor at relatively low cost. The design features enhancements, including trapping during execution of illegal instructions. The internal structure of the design yields relatively high performance, with a significant decrease, relative to other microprocessors that perform the same functions, in the number of microcycles needed to execute macroinstructions. The problem meant to be solved in designing this microprocessor was to provide a modest level of computational capability in a general-purpose processor while adding as little as possible to the power demand, size, and weight of a system into which the microprocessor would be incorporated. As designed, this microprocessor consumes very little power and occupies only a small portion of a typical modern ASIC or FPGA. The microprocessor operates at a rate of about 4 million instructions per second with clock frequency of 20 MHz.

  19. Newnes microprocessor pocket book

    Money, Steve

    2014-01-01

    Newnes Microprocessor Pocket Book explains the basic hardware operation of a microprocessor and describes the actions of the various types of instruction that can be executed. A summary of the characteristics of many of the popular microprocessors is presented. Apart from the popular 8- and 16-bit microprocessors, some details are also given of the popular single chip microcomputers and of the reduced instruction set computer (RISC) type processors such as the Transputer, Novix FORTH processor, and Acorn ARM processor.Comprised of 15 chapters, this book discusses the principles involved in bot

  20. Memory, microprocessor, and ASIC

    Chen, Wai-Kai

    2003-01-01

    System Timing. ROM/PROM/EPROM. SRAM. Embedded Memory. Flash Memories. Dynamic Random Access Memory. Low-Power Memory Circuits. Timing and Signal Integrity Analysis. Microprocessor Design Verification. Microprocessor Layout Method. Architecture. ASIC Design. Logic Synthesis for Field Programmable Gate Array (EPGA) Technology. Testability Concepts and DFT. ATPG and BIST. CAD Tools for BIST/DFT and Delay Faults.

  1. OS Friendly Microprocessor Architecture

    2017-04-01

    NOTES Patrick La Fratta is now affiliated with Micron Technology, Inc., Boise, Idaho. 14. ABSTRACT We present an introduction to the patented ...Operating System Friendly Microprocessor Architecture (OSFA). The software framework to support the hardware-level security features is currently patent ...Army is assignee. OS Friendly Microprocessor Architecture. United States Patent 9122610. 2015 Sep. 2. Jungwirth P, inventor; US Army is assignee

  2. AGARD Flight Test Instrumentation Series. Volume 18. Microprocessor Applications in Airborne Flight Test Instrumentation

    1987-02-01

    flowcharting . 3. ProEram Codin in HLL. This stage consists of transcribing the previously designed program into R an t at can be translated into the machine...specified conditios 7. Documentation. Program documentation is necessary for user information, for maintenance, and for future applications. Flowcharts ...particular CP U. Asynchronous. Operating without reference to an overall timing source. BASIC. Beginners ’ All-purpose Symbolic Instruction Code; a widely

  3. Dynamic instruction set extension of microprocessors with embedded FPGAs

    Bauer, Heiner

    2017-01-01

    Increasingly complex applications and recent shifts in technology scaling have created a large demand for microprocessors which can perform tasks more quickly and more energy efficient. Conventional microarchitectures exploit multiple levels of parallelism to increase instruction throughput and use application specific instruction sets or hardware accelerators to increase energy efficiency. Reconfigurable microprocessors adopt the same principle of providing application specific hardware, how...

  4. Proceedings of the meeting on applications of microprocessors in accelerator controls and physics experiments, Tsukuba, March 15, 1978

    Shibata, Shinkichi; Katoh, Tadahiko

    1978-05-01

    The microprocessor was first made public in 1971. In the ensuing few years, its performance has risen, cost lowered and interface more in IC, so it is now easily incorporated in instrumentation and control. Since it is used as electronic component unlike the case of a minicomputer, it has so much larger influence. It differs from the conventional electronic components in that software is required. In the National Laboratory for High Energy Physics, microprocessors are used for performance improvements of the measuring and control instruments and for labor saving. For new component not to induce new other problems, support system and standardization are proceeding for utilization development etc. The present meeting was intended for discussions by people in the field of usage, planning, and means of joint uses for software and hardware. (Mori, K.)

  5. Multi-core Microprocessors

    Based on empirical data, Gordon Moore .... there are numerous models of the same Intel microprocessor such as Pentium. 3). ... returns. The limit on instruction and thread-level processing coupled with ..... This style of parallel programming is.

  6. An INTEL 8080 microprocessor development system

    Horne, P.J.

    1977-01-01

    The INTEL 8080 has become one of the two most widely used microprocessors at CERN, the other being the MOTOROLA 6800. Even thouth this is the case, there have been, to date, only rudimentary facilities available for aiding the development of application programs for this microprocessor. An ideal development system is one which has a sophisticated editing and filing system, an assembler/compiler, and access to the microprocessor application. In many instances access to a PROM programmer is also required, as the application may utilize only PROMs for program storage. With these thoughts in mind, an INTEL 8080 microprocessor development system was implemented in the Proton Synchrotron (PS) Division. This system utilizes a PDP 11/45 as the editing and file-handling machine, and an MSC 8/MOD 80 microcomputer for assembling, PROM programming and debugging user programs at run time. The two machines are linked by an existing CAMAC crate system which will also provide the means of access to microprocessor applications in CAMAC and the interface of the development system to any other application. (Auth.)

  7. Radiation hardened COTS-based 32-bit microprocessor

    Haddad, N.; Brown, R.; Cronauer, T.; Phan, H.

    1999-01-01

    A high performance radiation hardened 32-bit RISC microprocessor based upon a commercial single chip CPU has been developed. This paper presents the features of radiation hardened microprocessor, the methods used to radiation harden this device, the results of radiation testing, and shows that the RAD6000 is well-suited for the vast majority of space applications. (authors)

  8. Microprocessor monitored Auger spectrometer

    Sapin, Michel; Ghaleb, Dominique; Pernot, Bernard.

    1982-05-01

    The operation of an Auger spectrometer, used for studying surface impurity diffusion, has been fully automatized with the help of a microprocessor. The characteristics, performance and practical use of the system are described together with the main advantage for the experimentator [fr

  9. Mol 7C/6; Mol 7C/6

    Aberle, J.; Schleisiek, K.; Schmuck, I.; Schmidt, L.; Romer, O.; Weih, G.

    1995-08-01

    The Mol 7C/6 coolant blockage experiment in the Belgian BR2 reactor yielded results different from Mol 7C experiments with low burnup pins: At 10% burnup local failure is not self-limiting, but requires active systems for detection and scram. The Mol 7C series was finished in 1991. In each of the test bundles Mol 7C/4, /5 and /6, 30 Mk I pins pre-irradiated in KNK II were used. The central blockage consisted of enriched UO{sub 2} covering 30 percent of the bundle cross-section, with a height of 40 mm. The most important system for timely detection of coolant blockages of the type studied in Mol 7C/6 is based on DND. (orig.)

  10. Microprocessor controller for stepping motors

    Strait, B.G.; Thuot, M.E.

    1977-01-01

    A new concept for digital computer control of multiple stepping motors which operate in a severe electromagnetic pulse environment is presented. The motors position mirrors in the beam-alignment system of a 100-kJ CO 2 laser. An asynchronous communications channel of a computer is used to send coded messages, containing the motor address and stepping-command information, to the stepping-motor controller in a bit serial format over a fiber-optics communications link. The addressed controller responds by transmitting to the computer its address and other motor information, thus confirming the received message. Each controller is capable of controlling three stepping motors. The controller contains the fiber-optics interface, a microprocessor, and the stepping-motor driven circuits. The microprocessor program, which resides in an EPROM, decodes the received messages, transmits responses, performs the stepping-motor sequence logic, maintains motor-position information, and monitors the motor's reference switch. For multiple stepping-motor application, the controllers are connected in a daisy chain providing control of many motors from one asynchronous communications channel of the computer

  11. The European Logarithmic Microprocessor

    Coleman, J. N.; Softley, C. I.; Kadlec, Jiří; Matoušek, R.; Tichý, Milan; Pohl, Zdeněk; Heřmánek, Antonín; Benschop, N. F.

    2008-01-01

    Roč. 57, č. 4 (2008), s. 532-546 ISSN 0018-9340 Grant - others:Evropská komise(BE) ESPRIT 33544 Institutional research plan: CEZ:AV0Z10750506 Source of funding: R - rámcový projekt EK Keywords : Processor architecture * arithmetic unit * logarithmic arithmetic Subject RIV: JC - Computer Hardware ; Software Impact factor: 2.611, year: 2008 http://library.utia.cas.cz/separaty/2008/ZS/kadlec-the%20european%20logarithmic%20microprocessor.pdf

  12. Microprocessor based image processing system

    Mirza, M.I.; Siddiqui, M.N.; Rangoonwala, A.

    1987-01-01

    Rapid developments in the production of integrated circuits and introduction of sophisticated 8,16 and now 32 bit microprocessor based computers, have set new trends in computer applications. Nowadays the users by investing much less money can make optimal use of smaller systems by getting them custom-tailored according to their requirements. During the past decade there have been great advancements in the field of computer Graphics and consequently, 'Image Processing' has emerged as a separate independent field. Image Processing is being used in a number of disciplines. In the Medical Sciences, it is used to construct pseudo color images from computer aided tomography (CAT) or positron emission tomography (PET) scanners. Art, advertising and publishing people use pseudo colours in pursuit of more effective graphics. Structural engineers use Image Processing to examine weld X-rays to search for imperfections. Photographers use Image Processing for various enhancements which are difficult to achieve in a conventional dark room. (author)

  13. A feedback microprocessor for hadron colliders

    Herrup, D.A.; Chapman, L.; Franck, A.; Groves, T.; Lublinsky, B.

    1992-12-01

    A feedback microprocessor has been built for the TEVATRON. It has been constructed to be applicable to hadron colliders in general. Its inputs are realtime accelerator measurements, data describing the state of the TEVATRON, and ramp tables. The microprocessor software includes a finite state machine. Each state corresponds to a specific TEVATRON operation and has a state-specific TEVATRON model. Transitions between states are initiated by the global TEVATRON clock. Each state includes a cyclic routine which is called periodically and where all calculations are performed. The output corrections are inserted onto a fast TEVATRON-wide link from which the power supplies will read the realtime corrections. We also store all of the input data and output corrections in a set of buffers which can easily be retrieved for diagnostic analysis. In this paper we will describe this device and its use to control the TEVATRON tunes as well as other possible applications

  14. CAMAC multipurpose microprocessor controller

    Belyakova, M.P.; Nemesh, T.; Buj Zoan Chong.

    1978-01-01

    The use of CAMAC controllers in an autonomous system of data acquisition and measurement is considered. The system consists of a control intelligence controller, memory modules, and user modules in the CAMAC standard. The controller and all the modules have an output into the highway and this permits to exchange data among them without using special external cables. To increase the servicing rate, an auxiliary controller which has direct access to memory and controls the user modules, is additionally connected to the data acquisition and measurement system. In this case, the intelligence controller is passive. The system of data acquisition can be realized in the form of a multiple system with branch usage. The controller module width is three units, and the controller incorporates the Intel-8080-type microprocessor and the following interfaces: of CAMAC highways, of interruption, of memory bootstrap, and of data sequence channel

  15. Introduction to 6800/6802 microprocessor systems hardware, software and experimentation

    Simpson, Robert J

    1987-01-01

    Introduction to 6800/6802 Microprocessor Systems: Hardware, Software and Experimentation introduces the reader to the features, characteristics, operation, and applications of the 6800/6802 microprocessor and associated family of devices. Many worked examples are included to illustrate the theoretical and practical aspects of the 6800/6802 microprocessor.Comprised of six chapters, this book begins by presenting several aspects of digital systems before introducing the concepts of fetching and execution of a microprocessor instruction. Details and descriptions of hardware elements (MPU, RAM, RO

  16. Microprocessor multi-task monitor

    Ludemann, C.A.

    1983-01-01

    This paper describes a multi-task monitor program for microprocessors. Although written for the Intel 8085, it incorporates features that would be beneficial for implementation in other microprocessors used in controlling and monitoring experiments and accelerators. The monitor places permanent programs (tasks) arbitrarily located throughout ROM in a priority ordered queue. The programmer is provided with the flexibility to add new tasks or modified versions of existing tasks, without having to comply with previously defined task boundaries or having to reprogram all of ROM. Scheduling of tasks is triggered by timers, outside stimuli (interrupts), or inter-task communications. Context switching time is of the order of tenths of a milllisecond

  17. Concept report: Microprocessor control of electrical power system

    Perry, E.

    1977-01-01

    An electrical power system which uses a microprocessor for systems control and monitoring is described. The microprocessor controlled system permits real time modification of system parameters for optimizing a system configuration, especially in the event of an anomaly. By reducing the components count, the assembling and testing of the unit is simplified, and reliability is increased. A resuable modular power conversion system capable of satisfying a large percentage of space applications requirements is examined along with the programmable power processor. The PC global controller which handles systems control and external communication is analyzed, and a software description is given. A systems application summary is also included.

  18. System architecture for microprocessor based protection system

    Gallagher, J.M. Jr.; Lilly, G.M.

    1976-01-01

    This paper discusses the architectural design features to be employed by Westinghouse in the application of distributed digital processing techniques to the protection system. While the title of the paper makes specific reference to microprocessors, this is only one (and the newest) of the building blocks which constitutes a distributed digital processing system. The actual system structure (as realized through utilization of the various building blocks) is established through considerations of reliability, licensability, and cost. It is the intent of the paper to address these considerations licenstions as they relate to the architectural design features. (orig.) [de

  19. Microprocessor control of a wind turbine generator

    Gnecco, A. J.; Whitehead, G. T.

    1978-01-01

    This paper describes a microprocessor based system used to control the unattended operation of a wind turbine generator. The turbine and its microcomputer system are fully described with special emphasis on the wide variety of tasks performed by the microprocessor for the safe and efficient operation of the turbine. The flexibility, cost and reliability of the microprocessor were major factors in its selection.

  20. Microprocessors control of fermentation process

    Fawzy, A S; Hinton, O R

    1980-01-01

    This paper presents three schemes for the solution of the optimal control of fermentation process. It also shows the advantages of using microprocessors in controlling and monitoring this process. A linear model of the system is considered. An optimal feedback controller is determined which maintains the states (substrate and organisms concentration) at desired values when the system is subjected to disturbances in the influent substrate and organisms concentration. Simulation results are presented for the three cases.

  1. Multichannel analyzer based on microprocessors

    Soares, M.

    1983-06-01

    A multichannel analyser for nuclear spectrometry, that would attend the needs of research laboratories and could be industrialized in Brazil, was developed. The design was based on INTEL 8080/85 microprocessors; other processors were also used to implement specific functions, such as shared busbar using direct memory access. A prototype was developed and tested through simulation, using a nuclear spectrometry chain. The results were fully satisfactory. (Author) [pt

  2. Microprocessor-controlled surface testing

    Droscha, H

    1982-09-01

    For the quality inspection on continuous flow material webs with transverse scanning laser beam, the microprocessor control, realized now for the first time in combination with appropriate units, shows a considerable progress. Thanks to the here used electronics, surface errors can be localized within the web according to their x-y-position, quantitative analysis can be carried out and automatic sorting and registration functions can be used.

  3. Technology transfer of military space microprocessor developments

    Gorden, C.; King, D.; Byington, L.; Lanza, D.

    1999-01-01

    Over the past 13 years the Air Force Research Laboratory (AFRL) has led the development of microprocessors and computers for USAF space and strategic missile applications. As a result of these Air Force development programs, advanced computer technology is available for use by civil and commercial space customers as well. The Generic VHSIC Spaceborne Computer (GVSC) program began in 1985 at AFRL to fulfill a deficiency in the availability of space-qualified data and control processors. GVSC developed a radiation hardened multi-chip version of the 16-bit, Mil-Std 1750A microprocessor. The follow-on to GVSC, the Advanced Spaceborne Computer Module (ASCM) program, was initiated by AFRL to establish two industrial sources for complete, radiation-hardened 16-bit and 32-bit computers and microelectronic components. Development of the Control Processor Module (CPM), the first of two ASCM contract phases, concluded in 1994 with the availability of two sources for space-qualified, 16-bit Mil-Std-1750A computers, cards, multi-chip modules, and integrated circuits. The second phase of the program, the Advanced Technology Insertion Module (ATIM), was completed in December 1997. ATIM developed two single board computers based on 32-bit reduced instruction set computer (RISC) processors. GVSC, CPM, and ATIM technologies are flying or baselined into the majority of today's DoD, NASA, and commercial satellite systems.

  4. Microprocessor-controlled CAMAC data link module

    Potter, J.M.

    1978-05-01

    Communication between the central control computer and remote, satellite data-acquisition/control stations at the Clinton P. Anderson Meson Physics Facility (LAMPF) is presently accomplished through the use of CAMAC-based Data Link modules. With the advent of the microprocessor, a new philosophy for digital data communications has evolved. Data Link modules containing microprocessor controllers provide link management and communication network protocol through algorithms executed in the Data Link microprocessor. 13 figures

  5. Microprocessor based systems for the higher technician

    Vears, RE

    2013-01-01

    Microprocessor Based Systems for the Higher Technician provides coverage of the BTEC level 4 unit in Microprocessor Based Systems (syllabus U80/674). This book is composed of 10 chapters and concentrates on the development of 8-bit microcontrollers specifically constructed around the Z80 microprocessor. The design cycle for the development of such a microprocessor based system and the use of a disk-based development system (MDS) as an aid to design are both described in detail. The book deals with the Control Program Monitor (CP/M) operating system and gives background information on file hand

  6. Microprocessor system for data acquisition and processing for the Flora device

    Klimov, V.M.

    1986-01-01

    ''VEhFORMIKA'' microprocessor system for data collection and processing when conducting experiments at the ''Flora'' device is described, its application is grounded. The complex allows one to conduct investigations using multichannel methods and exercise the device electrophysical control

  7. Contribution to the automatic command in robotics - Application to the command by microprocessors of the articulated systems; Contribution a la commande automatique en robotique. Application a la commande par microprocesseurs des manipulateurs articules

    Al Mouhamed, Mayez

    1982-01-29

    The first part of the present paper deals with the main methods of changing the coordinates for a general articulated system. After a definition of the coordinates changing, we propose a coordination system designed for easy programming of the movements. Its characteristic is to permit the action anywhere on the manipulated object. The second part deals with the force regulation problem. For this purpose we have developed a general force sensor. The informations delivered by the sensor are used by force regulators which are intended for the automatic assembly of subsystems. In the third part the dynamic problem of the articulated systems is exposed. We present a new method which allows to determine dynamic parameters from appropriate motions of the robot. These parameters are then used to implement the dynamic control. Several applications, using the powerful microprocessor INTEL 8086 and its arithmetic coprocessor 8087, are presented, in order to demonstrate the performances gained. (author) [French] Dans la premiere partie de ce memoire, nous exposons les principales methodes de changement de coordonnees pour un systeme articule general. Apres une definition adequate de ce dernier, nous proposons un systeme de coordination permettant une programmation facile des mouvements. Sa caracteristique est de prendre comme centre d'action un point quelconque de l'objet manipule. Dans la deuxieme partie, nous etudions la regulation en effort. Pour cela nous avons developpe un capteur de forces general. Les informations que delivre ce dernier sont utilisees par des regulateurs d'effort adaptes au contexte de l'assemblage automatique des pieces. Dans la troisieme partie, nous exposons une nouvelle methode de commande dynamique des systemes articules. Nous obtenons des parametres dynamiques du robot a partir de mouvements appropries. Ces derniers sont ensuite utilises dans l'elaboration des commandes. Des applications utilisant le microprocesseur INTEL 8086 avec son

  8. Microprocessor controlled digital period meter

    Keefe, D.J.; McDowell, W.P.; Rusch, G.K.

    1980-01-01

    A microprocessor controlled digital period meter has been developed and tested operationally on a reactor at Argonne National Laboratory. The principle of operation is the mathematical relationship between asymptotic periods and pulse counting circuitry. This relationship is used to calculate and display the reactor periods over a range of /plus or minus/1 second to /plus or minus/999 seconds. The time interval required to update each measurement automatically varies from 8 seconds at the lowest counting rates to 2 seconds at higher counting rates. The paper will describe hardware and software design details and show the advantages of this type of Period Meter over the conventional circuits. 1 ref

  9. Fermilab ACP multi-microprocessor project

    Gaines, I.; Areti, H.; Biel, J.; Bracker, S.; Case, G.; Fischler, M.; Husby, D.; Nash, T.

    1984-08-01

    We report on the status of the Fermilab Advanced Computer Program's project to provide more cost-effective computing engines for the high energy physics community. The project will exploit the cheap, but powerful, commercial microprocessors now available by constructing modular multi-microprocessor systems. A working test bed system as well as plans for the next stages of the project are described

  10. Microprocessor aided data acquisition at VEDAS

    Ziem, P.; Drescher, B.; Kapper, K.; Kowallik, R.

    1985-01-01

    Three microprocessor systems have been developed to support data acquisition in nuclear physics multiparameter experiments. A bit-slice processor accumulates up to 256 1-dim spectra and 16 2-dim spectra. A microprocessor, based on the AM 29116 ALU, performs a fast consistency check on the coincidence data. A VME-Bus double-processor displays a colored scatterplot

  11. Fermilab advanced computer program multi-microprocessor project

    Nash, T.; Areti, H.; Biel, J.

    1985-06-01

    Fermilab's Advanced Computer Program is constructing a powerful 128 node multi-microprocessor system for data analysis in high-energy physics. The system will use commercial 32-bit microprocessors programmed in Fortran-77. Extensive software supports easy migration of user applications from a uniprocessor environment to the multiprocessor and provides sophisticated program development, debugging, and error handling and recovery tools. This system is designed to be readily copied, providing computing cost effectiveness of below $2200 per VAX 11/780 equivalent. The low cost, commercial availability, compatibility with off-line analysis programs, and high data bandwidths (up to 160 MByte/sec) make the system an ideal choice for applications to on-line triggers as well as an offline data processor

  12. General-purpose microprocessor-based control chassis

    Halbig, J.K.; Klosterbuer, S.F.; Swenson, D.A.

    1979-12-01

    The objective of the Pion Generation for Medical Irradiations (PIGMI) program at the Los Alamos Scientific Laboratory is to develop the technology to build smaller, less expensive, and more reliable proton linear accelerators for medical applications. For this program, a powerful, simple, inexpensive, and reliable control and data acquisition system was developed. The system has a NOVA 3D computer with a real time disk-operating system (RDOS) that communicates with distributed microprocessor-based controllers which directly control data input/output chassis. At the heart of the controller is a microprocessor crate which was conceived at the Fermi National Accelerator Laboratory. This idea was applied to the design of the hardware and software of the controller

  13. Mold heating and cooling microprocessor conversion

    Hoffman, D. P.

    1995-07-01

    Conversion of the microprocessors and software for the Mold Heating and Cooling (MHAC) pump package control systems was initiated to allow required system enhancements and provide data communications capabilities with the Plastics Information and Control System (PICS). The existing microprocessor-based control systems for the pump packages use an Intel 8088-based microprocessor board with a maximum of 64 Kbytes of program memory. The requirements for the system conversion were developed, and hardware has been selected to allow maximum reuse of existing hardware and software while providing the required additional capabilities and capacity. The new hardware will incorporate an Intel 80286-based microprocessor board with an 80287 math coprocessor, the system includes additional memory, I/O, and RS232 communication ports.

  14. A microarchitecture for resource-limited superscalar microprocessors

    Basso, Todd David

    1999-11-01

    Microelectronic components in space and satellite systems must be resistant to total dose radiation, single-even upset, and latchup in order to accomplish their missions. The demand for inexpensive, high-volume, radiation hardened (rad-hard) integrated circuits (ICs) is expected to increase dramatically as the communication market continues to expand. Motorola's Complementary Gallium Arsenide (CGaAsTM) technology offers superior radiation tolerance compared to traditional CMOS processes, while being more economical than dedicated rad-hard CMOS processes. The goals of this dissertation are to optimize a superscalar microarchitecture suitable for CGaAsTM microprocessors, develop circuit techniques for such applications, and evaluate the potential of CGaAsTM for the development of digital VLSI circuits. Motorola's 0.5 mum CGaAsTM process is summarized and circuit techniques applicable to digital CGaAsTM are developed. Direct coupled FET, complementary, and domino logic circuits are compared based on speed, power, area, and noise margins. These circuit techniques are employed in the design of a 600 MHz PowerPCTM arithmetic logic unit. The dissertation emphasizes CGaASTM-specific design considerations, specifically, low integration level. A baseline superscalar microarchitecture is defined and SPEC95 integer benchmark simulations are used to evaluate the applicability of advanced architectural features to microprocessors having low integration levels. The performance simulations center around the optimization of a simple superscalar core, small-scale branch prediction, instruction prefetching, and an off-chip primary data cache. The simulation results are used to develop a superscalar microarchitecture capable of outperforming a comparable sequential pipeline, while using only 500,000 transistors. The architecture, running at 200 MHz, is capable of achieving an estimated 153 MIPS, translating to a 27% performance increase over a comparable traditional pipelined

  15. Microprocessor Protection of Power Reducing Transformers

    F. A. Romanuk

    2011-01-01

    Full Text Available The paper contains analysis of advantages and disadvantages of existing differential protection terminals of power reducing transformers. The paper shows that there are good reasons to develop microprocessor protection of power reducing transformer which contains required functions and settings and which is based on Belarusian principles of relay protection system construction. The paper presents functional structure of microprocessor terminal of power reducing transformer which is developed. 

  16. Microprocessor Protection of Power Reducing Transformers

    F. A. Romanuk; S. P. Korolev; M. S. Loman

    2011-01-01

    The paper contains analysis of advantages and disadvantages of existing differential protection terminals of power reducing transformers. The paper shows that there are good reasons to develop microprocessor protection of power reducing transformer which contains required functions and settings and which is based on Belarusian principles of relay protection system construction. The paper presents functional structure of microprocessor terminal of power reducing transformer which is developed. 

  17. ''NICRO'' microprogramming language for sectional microprocessors

    Semenov, Yu.A.; Chudakov, V.N.

    1982-01-01

    ''MICRO'' microprogramming input language developed for sectional microprocessors is described. The structure of micromanual, purpose of particular fields, the corresponding mne-- mocodes and requirements they have to meet are considered. Program for integer division with a sign written in the ''MICRO'' language is given as an example. The possibilities of modif ying the translator for its adaptation to different types of processor and microprocessor sets are analyzed

  18. Microprocessor controller for phasing the accelerator

    Howry, S.K.; Wilmunder, A.R.

    1977-03-01

    A microprocessor controller is being developed to perform automatic phasing of the SLAC accelerator. It will replace the existing relay/analog boxes which are ten years old. The new system is all solid state except for the stepping motors that drive the phase shifters. A description is given of the components of the system, the control algorithm, microprocessor hardware and software design and development, and interaction with SLAC's computer control system

  19. Radiation-hardened bulk Si-gate CMOS microprocessor family

    Stricker, R.E.; Dingwall, A.G.F.; Cohen, S.; Adams, J.R.; Slemmer, W.C.

    1979-01-01

    RCA and Sandia Laboratories jointly developed a radiation-hardened bulk Si-gate CMOS technology which is used to fabricate the CDP-1800 series microprocessor family. Total dose hardness of 1 x 10 6 rads (Si) and transient upset hardness of 5 x 10 8 rads (Si)/sec with no latch up at any transient level was achieved. Radiation-hardened parts manufactured to date include the CDP-1802 microprocessor, the CDP-1834 ROM, the CDP-1852 8-bit I/O port, the CDP-1856 N-bit 1 of 8 decoder, and the TCC-244 256 x 4 Static RAM. The paper is divided into three parts. In the first section, the basic fundamentals of the non-hardened C 2 L technology used for the CDP-1800 series microprocessor parts is discussed along with the primary reasons for hardening this technology. The second section discusses the major changes in the fabrication sequence that are required to produce radiation-hardened devices. The final section details the electrical performance characteristics of the hardened devices as well as the effects of radiation on device performance. Also included in this section is a discussion of the TCC-244 256 x 4 Static RAM designed jointly by RCA and Sandia Laboratories for this application

  20. Nuclear criticality evacuation with telemonitoring and microprocessors

    Fergus, R.W.; Moe, H.J. Sr.

    1979-01-01

    At Argonne National Laboratory, criticality alarms are required at widely separated locations to evacuate personnel in case of accident while emergency teams or maintenance personnel respond from a central location. The system functions have been divided in a similar manner. The alarm site hardware can independently detect a criticality and sound the evacuation signal while general monitoring and routine tests are handled by a communication link to a central monitoring station. The radiation detectors and evacuation sounders at each site are interconnected by a common two conductor cable in a unique telemonitoring format. This format allows both control and data information to be received or transmitted at any point on the cable which can be up to 3000 meters total length. The site microprocessor maintains a current data table, detects several faults, drives a printer, and communicates with the central telemonitoring station. The radiation detectors are made with plastic scintillators and photomultiplier tubes operated in a constant current mode with a 4 decade measurement range. The detectors also respond within microseconds to the criticality radiation burst. These characteristics can be tested with an internal light emitting diode either completely with a manual procedure or routinely with a system test initiated by the central monitoring station. Although the system was developed for a criticality alarm which requires reliable and redundant features, the basic techniques are useable for other monitoring and instrumentation applications

  1. FPGAs Emulate Microprocessors-A Successful Case for HFC NPP Digital I and C Upgrade

    Hsu, Allen; Crow, Ivan; Reese, Carl; Kim, Jong; Yang, Steve

    2014-01-01

    Field Programmable Gate Arrays (FPGAs), as programmable logic devices (PLDs) have gained a great deal of interests for implementing safety I and C applications in nuclear power plants (NPPs) largely owing to the FPGAs'potential advantage over the currently more common microprocessor-based digital I and C applications. First of all, FPGAs have adequate capabilities for most digital I and C applications in NPPs. Secondly, FPGAs provide products with longer lifetime, improve testability, and reduce the drift which occurs in analog-based systems, from hardware perspective. Thirdly, FPGAs, from software perspective, can be made simpler, less reliant on complex software such as operating systems, which should make FPGAs easier to qualify for nuclear safety applications. Fourthly, FPGAs are less vulnerable to cyber attacks when FPGAs implement the I and C systems that do not contain high-level, general purpose software that may be easily subjected to malicious modifications. Finally, FPGAs can bring cost reduction in an I and C digital upgrade because FPGAs can provide simpler licensing process than microprocessor-based digital I and C, and FPGAs can be implemented more efficiently. This paper will present one successful case for YGN Unit I and C upgrade using FPGA-based components to replace the obsolete Intel 8085 Microprocessor-based controllers. In this case, FPGAs emulated the process of the existing microprocessors and interpreted the execution of CPU processing. More than 160 of the FPGA-based SBC-01 controllers replacing the Intel 8085 Microprocessor-based Printed Circuit Boards have been installed and running successfully for safety I and C applications over the last five years. In this upgrade, the new FPGA-based controller board SBC-01 emulated the functions of Intel 8085 microprocessor correctly. It is a successful and cost-effective upgrade.vIn this paper, lifecycle design and implementation process and rigorous V and V activities that were used in the

  2. FPGAs Emulate Microprocessors-A Successful Case for HFC NPP Digital I and C Upgrade

    Hsu, Allen; Crow, Ivan; Reese, Carl; Kim, Jong; Yang, Steve [Doosan HF Controls Corp, Carrollton (United States)

    2014-08-15

    Field Programmable Gate Arrays (FPGAs), as programmable logic devices (PLDs) have gained a great deal of interests for implementing safety I and C applications in nuclear power plants (NPPs) largely owing to the FPGAs'potential advantage over the currently more common microprocessor-based digital I and C applications. First of all, FPGAs have adequate capabilities for most digital I and C applications in NPPs. Secondly, FPGAs provide products with longer lifetime, improve testability, and reduce the drift which occurs in analog-based systems, from hardware perspective. Thirdly, FPGAs, from software perspective, can be made simpler, less reliant on complex software such as operating systems, which should make FPGAs easier to qualify for nuclear safety applications. Fourthly, FPGAs are less vulnerable to cyber attacks when FPGAs implement the I and C systems that do not contain high-level, general purpose software that may be easily subjected to malicious modifications. Finally, FPGAs can bring cost reduction in an I and C digital upgrade because FPGAs can provide simpler licensing process than microprocessor-based digital I and C, and FPGAs can be implemented more efficiently. This paper will present one successful case for YGN Unit I and C upgrade using FPGA-based components to replace the obsolete Intel 8085 Microprocessor-based controllers. In this case, FPGAs emulated the process of the existing microprocessors and interpreted the execution of CPU processing. More than 160 of the FPGA-based SBC-01 controllers replacing the Intel 8085 Microprocessor-based Printed Circuit Boards have been installed and running successfully for safety I and C applications over the last five years. In this upgrade, the new FPGA-based controller board SBC-01 emulated the functions of Intel 8085 microprocessor correctly. It is a successful and cost-effective upgrade.vIn this paper, lifecycle design and implementation process and rigorous V and V activities that were used in the

  3. Automated mixed traffic transit vehicle microprocessor controller

    Marks, R. A.; Cassell, P.; Johnston, A. R.

    1981-01-01

    An improved Automated Mixed Traffic Vehicle (AMTV) speed control system employing a microprocessor and transistor chopper motor current controller is described and its performance is presented in terms of velocity versus time curves. The on board computer hardware and software systems are described as is the software development system. All of the programming used in this controller was implemented using FORTRAN. This microprocessor controller made possible a number of safety features and improved the comfort associated with starting and shopping. In addition, most of the vehicle's performance characteristics can be altered by simple program parameter changes. A failure analysis of the microprocessor controller was generated and the results are included. Flow diagrams for the speed control algorithms and complete FORTRAN code listings are also included.

  4. Microprocessor Card for Cuban Series polarimeters Laserpol

    Arista Romeu, E.; Mora Mazorra, W.

    2012-01-01

    We present the design consists of a card based on a micro-processor 8-bit adds new software components and their basic living, which allow to deliver new services and expand the possibilities for use in other applications of the polarimeter LASERPOL series, as the polarimetric detection. Given the limitations of the original card it was necessary to introduce a series of changes that would allow to address new user requirements, and expand the possible applications of the instruments. This was done the expansion of the capacity of the EPROM and RAM memory, the decoder circuit was implemented memory map using a programmable integrated circuit, and introduced a real time clock with nonvolatile RAM, these features are exploited to the introduction of new features such as the realization of the polarimeter calibration by the user from a sample pattern or a calibration pattern used as a reference, and the incorporation of the time and date to the reports of measurements required industry for quality control processes. Card that is achieved along with the rest of the components is compatible with polarimeters LASERPOL 101M Series, 3M and LP4, pin to pin, which facilitates their incorporation into the polarimeters in operation in the industry 'in situ' replacement cards from previous models, allowing to extend the possibilities of statistical processing, precision and accuracy of the instruments. Improved measurements in the industry, resulting in significant savings by elimination of losses in production and raw materials. The improved response speed of reading the polarimeters LASERPOL Use and polarimetric detectors. (Author)

  5. Microprocessor system design a practical introduction

    Spinks, Michael J

    2013-01-01

    Microprocessor System Design: A Practical Introduction describes the concepts and techniques incorporated into the design of electronic circuits, particularly microprocessor boards and their peripherals. The book reviews the basic building blocks of the electronic systems composed of digital (logic levels, gate output circuitry) and analog components (resistors, capacitors, diodes, transistors). The text also describes operational amplifiers (op-amp) that use a negative feedback technique to improve the parameters of the op-amp. The design engineer can use programmable array logic (PAL) to rep

  6. Neutron beam irradiation study of workload dependence of SER in a microprocessor

    Michalak, Sarah E [Los Alamos National Laboratory; Graves, Todd L [Los Alamos National Laboratory; Hong, Ted [STANFORD; Ackaret, Jerry [IBM; Sonny, Rao [IBM; Subhasish, Mitra [STANFORD; Pia, Sanda [IBM

    2009-01-01

    It is known that workloads are an important factor in soft error rates (SER), but it is proving difficult to find differentiating workloads for microprocessors. We have performed neutron beam irradiation studies of a commercial microprocessor under a wide variety of workload conditions from idle, performing no operations, to very busy workloads resembling real HPC, graphics, and business applications. There is evidence that the mean times to first indication of failure, MTFIF defined in Section II, may be different for some of the applications.

  7. Microprocessor protection relays: new prospects or new problems?

    Gurevich, Vladimir

    2006-01-01

    The internal architecture and principles of operation of microprocessor-based devices including so-called "microprocessor protective relays" have little in common with devices called "electric relays". But microprocessor-based relay protection devices are gradually driving out the traditional electromechanical and even electronic relay protection of virtually from all fields of power and electrical engineering. Advantages of microprocessor-based protection means over traditional ones are far ...

  8. Monitoring with new microprocessor cuts cost of control system

    Maehling, K L

    1985-08-01

    Programmable logic controllers (PLC) were originally developed as an alternative to relays, counters and timers for sequential and interlock control systems. They are now also used as part of distributive control systems which include diagnostic monitoring functions. The paper describes how a wiring scheme can be simplified and installation costs reduced by incorporating a newly-developed microprocessor-based monitoring device as an interface between remote devices and a PLC. An industrial application, the 400 tph coal handling facility at Bowater Southern Paper Co's mill in Calhoun, Tennessee, is considered. The control system design is outlined, the micro-monitor is described and the benefits of simplicity are stated in the paper.

  9. Antiproliferative activity of some novel platinum complexes on C6 ...

    MCF-7) and glioma cells (C6). IC50 values of the three compounds were lower in the cisplatin-resistant cell type C6 cell lines than in MCF-7 cells. Key words: Cisplatin, antiproliferative activity, breast cancer cells (MCF-7), glioma cells (C6), IC50.

  10. Microprocessors: From basic chips to complete systems

    Dobinson, R.W.

    1985-01-01

    These lectures aim to present and explain in general terms some of the characteristics of microprocessor chips and associated components. They show how systems are synthesized from the basic integrated circuit building blocks which are currently available; processor, memory, input-output (I/0) devices, etc. (orig./HSI)

  11. Microprocessor Controlled Capacitor Bank Switching System for ...

    In this work, analysis and development of a microprocessor controlled capacitor bank switching system for deployment in a smart distribution network was carried out. This system was implemented by the use of discreet components such as resistors, capacitors, transistor, diode, automatic voltage regulator, with the ...

  12. C_6_0"3"- versus C_6_0"4"- /C_6_0"2"- - synthesis and characterization of five salts containing discrete fullerene anions

    Boeddinghaus, M. Bele; Klein, Wilhelm; Wahl, Bernhard; Faessler, Thomas F.; Jakes, Peter; Eichel, Ruediger A.

    2014-01-01

    Five new compounds, [Rb(18crown-6)]_3[C_6_0] (1), [Rb(18crown-6)]_6[C_6_0]_2(C_3H_7NO)_2(C_4H_8O)_2 (2), [Rb(benzo18crown-6)]_6[C_6_0]_2(C_2H_8N_2)_5 (3), [Cs(benzo18crown-6)]_3C_6_0(C_2H_8N_2)_2 (4), and [Cs_3(benzo18crown-6)_5]C_6_0(C_2H_8N_2)_(_4_._5_+_x_) (5) were synthesized and characterized by single-crystal X-ray structure determination. All compounds contain discrete C_6_0 anions, which are ordered in 1, 2, and 4, where direct cation-anion contacts occur. The unit cells of 1 and 2 contain two independent fullerides, which coordinate to the rubidium atoms either of two or of four [Rb(18crown-6)] units. Owing to the presence of differently coordinated fullerene units in compounds 1 and 2, a possible disproportionation of C_6_0"3"- into C_6_0"2"- and C_6_0"4"- anions is discussed. In 3 and 4 the C_6_0 anions are coordinated by three Rb and Cs atoms, respectively. In all compounds the average charge of the anion is -3. Magnetic data reveal a doublet spin state for 3. The EPR spectra are discussed for compounds 3 and 5. The role of a dynamic Jahn-Teller distortion is discussed, and we report the first IR spectroscopic data of fullerene trianions, which have been obtained in solution. (Copyright copyright 2014 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  13. A microprocessor controlled read out system for drift chambers

    Centro, Sandro; Cittolin, Sergio; Dreesen, P; Petrolo, E; Rubbia, Carlo; Schinzel, D

    1981-01-01

    Summary form only given, as follows. A General Purpose Microprocessor Controller GPMC has been developed for applications where CAMAC modules with complex control functions are needed. Each application requires an appropriate Interface Module (IM) to be connected to the GPMC. The GPMC consists of a 6800 Microprocessor, 16K EPROM, 2K RAM, CAMAC I/O ports and interface, a RS 232C serial interface, an Advanced Data Link controller and a port for controlling the IM, GPMC and IM are housed in a 2-U wide CAMAC module. A special IM has been designed, which has 1K bute of RAM with its own control and which allows autonomous setting and reading analog voltages through a DAC and ADC. The GPMC can take control of the IM memory and set new voltages. This system is used to control pedestals and gains of a driftchamber readout system, which is housed in a 5-U wide CAMAC module, holding 24 data cards corresponding to 24 sense wires. The data card receives pulses from the left and right end of a sense wire, amplifies and int...

  14. Transducers and microprocessors in oceanographic applications

    Desai, R.G.P.; Desa, E.

    Transducers used for the sensing of the ten most measured marine parameters have been described in this paper. The ten parameters have been classed under 5 sensor types, namely temperature, pressure, salinity, currents and waves. For each sensor...

  15. Isomerisation of c4-c6 aldoses with zeolites

    2014-01-01

    The present invention relates to isomerization of C4-C6 aldoses to their corresponding C4-C6 ketoses. In particular, the invention concerns isomerization of C4-C6 aldoses over solid zeolite catalysts free of any metals other than aluminum, in the presence of suitable solvent(s) at suitable elevated...... temperatures. C6 and C5 aldose sugars such as glucose and xylose, which are available in large amounts from biomass precursors, are isomerized to fructose and xylulose respectively, in a one or two-step process over inexpensive commercially available zeolite catalysts, containing aluminum as the only metal...

  16. Microprocessor-controlled scanning densitometer system

    Shurtliff, R.W.

    1980-04-01

    An Automated Scanning Densitometer System has been developed by uniting a microprocessor with a low energy x-ray densitometer system. The microprocessor controls the detector movement, provides self-calibration, compensates raw readings to provide time-linear output, controls both data storage and the host computer interface, and provides measurement output in engineering units for immediate reading. The densitometer, when used in a scanning mode, is a precision reference instrument that provides chordal average density measurements over the cross section of a pipe under steady-state flow conditions. Results have shown an improvement over the original densitometer in reliability and repeatability of the system, an a factor-of-five improvement in accuracy

  17. Microprocessors in physics experiments at SLAC

    Rochester, L.S.

    1981-01-01

    The increasing size and complexity of high energy physics experiments is changing the way data are collected. To implement a trigger or event filter requires complex logic which may have to be modified as the experiment proceeds. Simply to monitor a detector, large amounts of data must be processed online. The use of microprocessors or other programmable devices can help to achieve these ends flexibly and economically. At SLAC, a number of microprocessor-based systems have been built and are in use in experimental setups, and others are now being developed. This talk is a review of existing systems and their use in experiments, and of developments in progress and future plans. (orig.)

  18. Microprocessors in physics experiments at SLAC

    Rochester, L.S.

    1981-04-01

    The increasing size and complexity of high energy physics experiments is changing the way data are collected. To implement a trigger or event filter requires complex logic which may have to be modified as the experiment proceeds. Simply to monitor a detector, large amounts of data must be processed on line. The use of microprocessors or other programmable devices can help to achieve these ends flexibly and economically. At SLAC, a number of microprocessor-based systems have been built and are in use in experimental setups, and others are now being developed. This talk is a review of existing systems and their use in experiments, and of developments in progress and future plans

  19. A realtime feedback microprocessor for the TEVATRON

    Herrup, D.A.; Chapman, L.; Franck, A.; Groves, T.; Lublinsky, B.

    1993-01-01

    A feedback microprocessor has been built for the TEVATRON. Its inputs are realtime accelerator measurements, data describing the state of the TEVATRON, and ramp tables. The microprocessor includes a finite state machine. Each state corresponds to a specific TEVATRON operation. Transitions between states are initiated by the global TEVATRON clock. Each state includes a cyclic routine which is called periodically and where all calculations are performed. The output corrections are inserted onto a fast TEVATRON-wide link from which the power supplies will read the realtime correction. The authors also store all of the input data and output corrections in a set of buffers which can easily be retrieved for diagnostic analysis. This talk will describe use of this device to control the TEVATRON tunes and discuss other uses

  20. Multiple microprocessor based nuclear reactor power monitor

    Lewis, P.S.; Ethridge, C.D.

    1979-01-01

    The reactor power monitor is a portable multiple-microprocessor controlled data acquisition device being built for the International Atomic Energy Association. Its function is to measure and record the hourly integrated operating thermal power level of a nuclear reactor for the purpose of detecting unannounced plutonium production. The monitor consists of a 3 He proportional neutron detector, a write-only cassette tape drive and control electronics based on two INTEL 8748 microprocessors. The reactor power monitor operates from house power supplied by the plant operator, but has eight hours of battery backup to cover power interruptions. Both the hourly power levels and any line power interruptions are recorded on tape and in memory. Intermediate dumps from the memory to a data terminal or strip chart recorder can be performed without interrupting data collection

  1. Cardiac output measurement instruments controlled by microprocessors

    Spector, M.; Barritault, L.; Boeri, C.; Fauchet, M.; Gambini, D.; Vernejoul, P. de

    The nuclear medicine and biophysics laboratory of the Necker-Enfants malades University Hospital Centre has built a microprocessor controlled Cardiac flowmetre. The principle of the cardiac output measurement from a radiocardiogram is well established. After injection of a radioactive indicator upstream from the heart cavities the dilution curve is obtained by the use of a gamma-ray precordial detector. This curve normally displays two peaks due to passage of the indicator into the right and left sides of the heart respectively. The output is then obtained from the stewart Hamilton principle once recirculation is eliminated. The graphic method used for the calculation however is long and tedious. The decreasing fraction of the dilution curve is projected in logarithmic space in order to eliminate recirculation by determining the mean straight line from which the decreasing exponential is obtained. The principle of the use of microprocessors is explained (electronics, logics) [fr

  2. Hardware math for the 6502 microprocessor

    Kissel, R.; Currie, J.

    1985-01-01

    A floating-point arithmetic unit is described which is being used in the Ground Facility of Large Space Structures Control Verification (GF/LSSCV). The experiment uses two complete inertial measurement units and a set of three gimbal torquers in a closed loop to control the structural vibrations in a flexible test article (beam). A 6502 (8-bit) microprocessor controls four AMD 9511A floating-point arithmetic units to do all the computation in 20 milliseconds.

  3. Microprocessor-based stepping motor driver

    Halbig, J.K.; Klosterbuer, S.F.

    1979-09-01

    The Pion Generation for Medical Irradiations (PIGMI) program at the Los Alamos Scientific Laboratory requires a versatile stepping motor driver to do beam diagnostic measurements. A driver controlled by a microprocessor that can move eight stepping motors simultaneously was designed. The driver can monitor and respond to clockwise- and counterclockwise-limit switches, and it can monitor a 0- to 10-V dc position signal. The software controls start and stop ramping and maximum stepping rates. 2 figures, 1 table

  4. The specifications a multichannel analyser using microprocessor

    Pontes, E.W.

    The idea of a small nuclear data acquisition system (stand - alone CAMAC system) used for spectroscopy, is presented. The system is composed by an autonomous controller with microprocessor with one fast programable unit (1-2 μsec/CAMAC instructions) and with modulus of general functions as: CAMAC memory, interface for video, interface for analogy to digital converter and temporizing. (E.G.) [pt

  5. Some software algorithms for microprocessor ratemeters

    Savic, Z.

    1991-01-01

    After a review of the basic theoretical ratemeter problem and a general discussion of microprocessor ratemeters, a short insight into their hardware organization is given. Three software algorithms are described: the old ones the quasi-exponential and floating mean algorithm, and a new weighted moving average algorithm. The equations for statistical characterization of the new algorithm are given and an intercomparison is made. It is concluded that the new algorithm has statistical advantages over the old ones. (orig.)

  6. Some software algorithms for microprocessor ratemeters

    Savic, Z. (Military Technical Inst., Belgrade (Yugoslavia))

    1991-03-15

    After a review of the basic theoretical ratemeter problem and a general discussion of microprocessor ratemeters, a short insight into their hardware organization is given. Three software algorithms are described: the old ones the quasi-exponential and floating mean algorithm, and a new weighted moving average algorithm. The equations for statistical characterization of the new algorithm are given and an intercomparison is made. It is concluded that the new algorithm has statistical advantages over the old ones. (orig.).

  7. LSI microprocessor circuit families based on integrated injection logic. Mikroprotsessornyye komplekty bis na osnove integral'noy inzhektsionnoy logiki

    Borisov, V.S.; Vlasov, F.S.; Kaloshkin, E.P.; Serzhanovich, D.S.; Sukhoparov, A.I.

    1984-01-01

    Progress in developing microprocessor computer hardware is based on progress and improvement in systems engineering, circuit engineering and manufacturing process methods of design and development of large-scale integrated circuits (BIS). Development of these methods with widespread use of computer-aided design (CAD) systems has allowed developing 4- and 8-bit microprocessor families (MPK) of LSI circuits based on integrated injection logic (I/sup 2/L), characterized by relatively high speed and low dissipated power. The emergence of LSI and VLSI microprocessor circuits required computer system developers to make changes to theory and practice of computer system design. Progress in technology upset the established relation between hardware and software component development costs in systems being designed. A characteristic feature of using LSI circuits is also the necessity of building devices from standard modules with large functional complexity. The existing directions of forming compositions of LSI microprocessor families allow the system developer to choose a particular methodology of design, proceeding from the efficiency function and field of application of the system being designed. The efficiency of using microprocessor families is largely governed by the user's understanding in depth of the structure of LSI microprocessor family circuits and the features of using them to implement a broad class of computer devices and modules being developed. This book is devoted to solving this problem.

  8. Unresolved problems in superconductivity of CaC6

    Mazin, I.I.; Boen, L.; Dolgov, O.V.; Golubov, Alexandre Avraamovitch; Bachelet, G.B.; Giantomassi, M.; Andersen, O.K.

    2007-01-01

    We discuss the current status of the theory of the “high-temperature” superconductivity in intercalated graphites YbC6 and CaC6. We emphasize that while the general picture of conventional, phonon-driven superconductivity has already emerged and is generally accepted, there are still interesting

  9. CAMAC based computer--computer communications via microprocessor data links

    Potter, J.M.; Machen, D.R.; Naivar, F.J.; Elkins, E.P.; Simmonds, D.D.

    1976-01-01

    Communications between the central control computer and remote, satellite data acquisition/control stations at The Clinton P. Anderson Meson Physics Facility (LAMPF) is presently accomplished through the use of CAMAC based Data Link Modules. With the advent of the microprocessor, a new philosophy for digital data communications has evolved. Data Link modules containing microprocessor controllers provide link management and communication network protocol through algorithms executed in the Data Link microprocessor

  10. SNOOP module CAMAC interface to the 168/E microprocessor

    Bernstein, D.; Carroll, J.T.; Mitnick, V.H.; Paffrath, L.; Parker, D.B.

    1979-10-01

    A pair of 168/E microprocessors will be used to meet the realtime computing requirements of the SLAC Hybrid Facility. A SNOOP module and 168/E Interface provide the link between the host computer and the microprocessors. By eavesdropping on normal CAMAC read operations, the SNOOP provides a direct data transfer from CAMAC to microprocessor memory. The host computer controls the processors using standard CAMAC programmed I/O to the SNOOP

  11. New On-board Microprocessors

    Weigand, R.

    Two new processor devices have been developed for the use on board of spacecrafts. An 8-bit 8032-microcontroller targets typical controlling applications in instruments and sub-systems, or could be used as a main processor on small satellites, whereas the LEON 32-bit SPARC processor can be used for high performance controlling and data processing tasks. The ADV80S32 is fully compliant to the Intel 80x1 architecture and instruction set, extended by additional peripherals, 512 bytes on-chip RAM and a bootstrap PROM, which allows downloading the application software using the CCSDS PacketWire pro- tocol. The memory controller provides a de-multiplexed address/data bus, and allows to access up to 16 MB data and 8 MB program RAM. The peripherals have been de- signed for the specific needs of a spacecraft, such as serial interfaces compatible to RS232, PacketWire and TTC-B-01, counters/timers for extended duration and a CRC calculation unit accelerating the CCSDS TM/TC protocol. The 0.5 um Atmel manu- facturing technology (MG2RT) provides latch-up and total dose immunity; SEU fault immunity is implemented by using SEU hardened Flip-Flops and EDAC protection of internal and external memories. The maximum clock frequency of 20 MHz allows a processing power of 3 MIPS. Engineering samples are available. For SW develop- ment, various SW packages for the 8051 architecture are on the market. The LEON processor implements a 32-bit SPARC V8 architecture, including all the multiply and divide instructions, complemented by a floating-point unit (FPU). It includes several standard peripherals, such as timers/watchdog, interrupt controller, UARTs, parallel I/Os and a memory controller, allowing to use 8, 16 and 32 bit PROM, SRAM or memory mapped I/O. With on-chip separate instruction and data caches, almost one instruction per clock cycle can be reached in some applications. A 33-MHz 32-bit PCI master/target interface and a PCI arbiter allow operating the device in a plug-in card

  12. Plastocyanin/cytochrome c6 interchange in Scenedesmus vacuolatus.

    Miramar, M Dolores; Inda, Luis A; Saraiva, Lígia M; Peleato, M Luisa

    2003-12-01

    Plastocyanin and cytochrome c6 from the green alga Scenedesmus vacuolatus were immunoquantified in cells grown under different concentrations of copper and iron. Plastocyanin expression was constitutive, its synthesis was not significantly affected by iron availability, and increases with copper availability. On the contrary, cytochrome c6 synthesis is repressed by copper, and only residual amounts of the protein were detected at 0.1 micromol/L copper. Under copper deficiency, cytochrome c6 is slightly dependent on iron. In natural environments, plastocyanin seems to be the predominant electron donor to P700.

  13. Microprocessor-controlled portable neutron spectrometer

    Hunt, G.F.; Kaifer, R.C.; Slaughter, D.R.; Strout, R.E. II; Rueppel, D.W.

    1979-01-01

    A neutron spectrometer that acquires and unfolds data in the field has been developed for use in the energy range from 1 to 20 MeV. The system includes an NE213 organic scintillation detector, automatic gain stabilization, automatically stabilized pulseshape discrimination, an LSl-11 microprocessor for control and data reduction, and a multichannel analyzer for data acquisition. The system, with the exception of the multichannel analyzer, is mounted in a suitcase 47 by 66 by 23.5 cm. The mass is 23.5 kg

  14. Microprocessor-based accelerating power level detector

    Nagpal, M.; Zarecki, W.; Albrecht, J.C.

    1994-01-01

    An accelerating power level detector was built using state-of-the-art microprocessor technology at Powertech Labs Inc. The detector will monitor the real power flowing in two 300 kV transmission lines out of Kemano Hydroelectric Generating Station and will detect any sudden loss of load due to a fault on either line under certain pre-selected power flow conditions. This paper discusses the criteria of operation for the detector and its implementation details, including digital processing, hardware, and software.

  15. Microprocessor architectures RISC, CISC and DSP

    Heath, Steve

    1995-01-01

    'Why are there all these different processor architectures and what do they all mean? Which processor will I use? How should I choose it?' Given the task of selecting an architecture or design approach, both engineers and managers require a knowledge of the whole system and an explanation of the design tradeoffs and their effects. This is information that rarely appears in data sheets or user manuals. This book fills that knowledge gap.Section 1 provides a primer and history of the three basic microprocessor architectures. Section 2 describes the ways in which the architectures react with the

  16. Future microprocessor farms: Offline and online

    Areti, H.

    1990-01-01

    Microprocessor farms have been successfully employed in high energy physics for both offline analysis and online triggers. As the experiments continue to grow in size, so do the demands for processing power. The preliminary indications are that the large collider experiments will require at least a million VAX-11/780 equivalents of processing power for online trigger decisions and offline event reconstruction. This paper examines the current technology trends and projects the processing power that may be expected with the current farm architectures. 3 refs., 6 figs

  17. Microprocessor-controlled, programmable ramp voltage generator

    Hopwood, J.

    1978-11-01

    A special-purpose voltage generator has been developed for driving the quadrupole mass filter of a residual gas analyzer. The generator is microprocessor-controlled with desired ramping parameters programmed by setting front-panel digital thumb switches. The start voltage, stop voltage, and time of each excursion are selectable. A maximum of five start-stop levels may be pre-selected for each program. The ramp voltage is 0 to 10 volts with sweep times from 0.1 to 999.99 seconds

  18. Satisfying STEM Education Using the Arduino Microprocessor in C Programming

    Hoffer, Brandyn M.

    There exists a need to promote better Science Technology Engineering and Math (STEM) education at the high school level. To satisfy this need a series of hands-on laboratory assignments were created to be accompanied by 2 educational trainers that contain various electronic components. This project provides an interdisciplinary, hands-on approach to teaching C programming that meets several standards defined by the Tennessee Board of Education. Together the trainers and lab assignments also introduce key concepts in math and science while allowing students hands-on experience with various electronic components. This will allow students to mimic real world applications of using the C programming language while exposing them to technology not currently introduced in many high school classrooms. The developed project is targeted at high school students performing at or above the junior level and uses the Arduino Mega open-source Microprocessor and software as the primary control unit.

  19. Software tools for microprocessor based systems

    Halatsis, C.

    1981-01-01

    After a short review of the hardware and/or software tools for the development of single-chip, fixed instruction set microprocessor-based sytems we focus on the software tools for designing systems based on microprogrammed bit-sliced microprocessors. Emphasis is placed on meta-microassemblers and simulation facilties at the register-transfer-level and architecture level. We review available meta-microassemblers giving their most important features, advantages and disadvantages. We also make extentions to higher-level microprogramming languages and associated systems specifically developed for bit-slices. In the area of simulation facilities we first discuss the simulation objectives and the criteria for chosing the right simulation language. We consertrate to simulation facilities already used in bit-slices projects and discuss the gained experience. We conclude by describing the way the Signetics meta-microassembler and the ISPS simulation tool have been employed in the design of a fast microprogrammed machine, called MICE, made out of ECL bit-slices. (orig.)

  20. Kinematic characteristics of tenodesis grasp in C6 quadriplegia.

    Mateo, S; Revol, P; Fourtassi, M; Rossetti, Y; Collet, C; Rode, G

    2013-02-01

    Descriptive control case study. To analyze the kinematics of tenodesis grasp in participants with C6 quadriplegia and healthy control participants in a pointing task and two daily life tasks involving a whole hand grip (apple) or a lateral grip (floppy disk). France. Four complete participants with C6 quadriplegia were age matched with four healthy control participants. All participants were right-handed. The measured kinematic parameters were the movement time (MT), the peak velocity (PV), the time of PV (TPV) and the wrist angle in the sagittal plane at movement onset, at the TPV and at the movement end point. The participants with C6 quadriplegia had significantly longer MTs in both prehension tasks. No significant differences in TPV were found between the two groups. Unlike control participants, for both prehension tasks the wrist of participants with C6 quadriplegia was in a neutral position at movement onset, in flexion at the TPV, and in extension at the movement end point. Two main kinematic parameters characterize tenodesis grasp movements in C6 quadriplegics: wrist flexion during reaching and wrist extension during the grasping phase, and increased MT reflecting the time required to adjust the wrist's position to achieve the tenodesis grasp. These characteristics were observed for two different grips (whole hand and lateral grip). These results suggest sequential planning of reaching and tenodesis grasp, and should be taken into account for prehension rehabilitation in patients with quadriplegia.

  1. High temperature hydrogenation of CaC6

    Srinivas, G.; Howard, C.A.; Skipper, N.T.; Bennington, S.M.; Ellerby, M.

    2009-01-01

    The structure and superconducting properties of high temperature hydrogenated calcium-graphite intercalation compound, CaC 6 have been investigated using room temperature X-ray diffraction, and temperature and field dependence of magnetisation. It is found that the hydrogenation can only decompose the CaC 6 phase, and generate a mixture of CaH 2 and graphite as the final compound. The hydrogenation of CaC 6 also reveals a degradation of its superconducting properties. The experimental results are discussed in detail and it is found that the formation of stable CaH 2 and deintercalation are the main source for observed phase separation and suppression in superconductivity.

  2. Microprocessor-controlled time domain reflectometer for dynamic shock position measurements

    Virchow, C.F.; Conrad, G.E.; Holt, D.M.; Hodson, E.K.

    1980-01-01

    Time-domain reflectometry is used in a novel way to measure dynamically shock propagation in various media. The primary component in this measurement system is a digital time domain reflectometer, which uses local intelligence, a Motorola 6800 microprocessor, to make the unit adaptable and versatile. The recorder, its operating theory and its method of implementation are described and typical data are reviewed. Applications include nuclear explosion yield estimates and explosive energy flow measurements

  3. Front-end data processing using the bit-sliced microprocessor

    Machen, D.R.

    1979-01-01

    A state-of-the-art computing device, based upon the high-speed bit-sliced microprocessor, was developed into hardware for front-end data processing in both control and experiment applications at the Los Alamos Scientific Laboratory. The CAMAC Instrumentation Standard provides the framework for the high-speed hardware, allowing data acquisition and processing to take place at the data source in a CAMAC crate. 5 figures

  4. A microprocessor based mobile radiation survey system

    Gilbert, R.W.; McCormack, W.D.

    1984-01-01

    A microprocessor-based system has been designed and constructed to enhance the performance of routine radiation surveys on roads within the Hanford site. This device continually monitors system performance and output from four sodium iodide detectors mounted on the rear bumper of a 4-wheel drive truck. The gamma radiation count rate in counts-per-second is monitored, and a running average computed, with the results compared to predefined limits. If an abnormal instantaneous or average count rate is detected, an alarm is sounded with responsible data displayed on a liquid crystal panel in the cab of the vehicle. The system also has the capability to evaluate detector output using multiple time constants and to perform more complex tests and comparison of the data. Data can be archived for later analysis on conventional chart recorders or stored in digital form on magnetic tape or other digital storage media

  5. Microprocessor based mobile radiation survey system

    Gilbert, R.W.; McCormack, W.D.

    1983-12-01

    A microprocessor-based system has been designed and constructed to enhance the performance of routine radiation surveys on roads within the Hanford site. This device continually monitors system performance and output from four sodium iodide detectors mounted on the rear bumper of a 4-wheel drive truck. The gamma radiation count rate in counts-per-second is monitored, and a running average computed, with the results compared to predefined limits. If an abnormal instantaneous or average count rate is detected, an alarm is sounded with responsible data displayed on a liquid crystal panel in the cab of the vehicle. The system also has the capability to evaluate detector output using multiple time constants and to perform more complex tests and comparison of the data. Data can be archived for later analysis on conventional chart recorders or stored in digital form on magnetic tape or other digital storage media. 4 figures

  6. Microprocessor-based integrated LMFBR core surveillance

    Gmeiner, L.

    1984-06-01

    This report results from a joint study of KfK and INTERATOM. The aim of this study is to explore the advantages of microprocessors and microelectronics for a more sophisticated core surveillance, which is based on the integration of separate surveillance techniques. Due to new developments in microelectronics and related software an approach to LMFBR core surveillance can be conceived that combines a number of measurements into a more intelligent decision-making data processing system. The following techniques are considered to contribute essentially to an integrated core surveillance system: - subassembly state and thermal hydraulics performance monitoring, - temperature noise analysis, - acoustic core surveillance, - failure characterization and failure prediction based on DND- and cover gas signals, and - flux tilting techniques. Starting from a description of these techniques it is shown that by combination and correlation of these individual techniques a higher degree of cost-effectiveness, reliability and accuracy can be achieved. (orig./GL) [de

  7. Microprocessor system for temperature regulation and stabilization

    Nguyen Nhi Dien; Rodionov, K.G.

    1989-01-01

    Microprocessor based system for temperature regulation and stabilization of an operation external object is described. The system has the direct current amplifier working according to modulator-demodulator principle. The overal gain is 100, 1000, 2000. The maximum output signal is ±10 V. The power amplifier is a thyristor one and its line voltage is 220 V, 50 Hz. The output power is 0-2 kVA. The microcontroller has a remote display terminal. Data input is 8 and data output is one. Input and output voltage is ±(0-10) V. The preselection time for stabilization is within 1 s - 18 h. The program algorithm is given. 5 figs.; 1 tab

  8. Low cost design of microprocessor EDAC circuit

    Hao Li; Yu Lixin; Peng Heping; Zhuang Wei

    2015-01-01

    An optimization method of error detection and correction (EDAC) circuit design is proposed. The method involves selecting or constructing EDAC codes of low cost hardware, associated with operation scheduling implementation based on 2-input XOR gates structure, and two actions for reducing hardware cells, which can reduce the delay penalties and area costs of the EDAC circuit effectively. The 32-bit EDAC circuit hardware implementation is selected to make a prototype, based on the 180 nm process. The delay penalties and area costs of the EDAC circuit are evaluated. Results show that the time penalty and area cost of the EDAC circuitries are affected with different parity-check matrices and different hardware implementation for the EDAC codes with the same capability of correction and detection code. This method can be used as a guide for low-cost radiation-hardened microprocessor EDAC circuit design and for more advanced technologies. (paper)

  9. Microprocessors & their operating systems a comprehensive guide to 8, 16 & 32 bit hardware, assembly language & computer architecture

    Holland, R C

    1989-01-01

    Provides a comprehensive guide to all of the major microprocessor families (8, 16 and 32 bit). The hardware aspects and software implications are described, giving the reader an overall understanding of microcomputer architectures. The internal processor operation of each microprocessor device is presented, followed by descriptions of the instruction set and applications for the device. Software considerations are expanded with descriptions and examples of the main high level programming languages (BASIC, Pascal and C). The book also includes detailed descriptions of the three main operatin

  10. A microprocessor based picture analysis system for automatic track measurements

    Heinrich, W.; Trakowski, W.; Beer, J.; Schucht, R.

    1982-01-01

    In the last few years picture analysis became a powerful technique for measurements of nuclear tracks in plastic detectors. For this purpose rather expensive commercial systems are available. Two inexpensive microprocessor based systems with different resolution were developed. The video pictures of particles seen through a microscope are digitized in real time and the picture analysis is done by software. The microscopes are equipped with stages driven by stepping motors, which are controlled by separate microprocessors. A PDP 11/03 supervises the operation of all microprocessors and stores the measured data on its mass storage devices. (author)

  11. The engineering of microprocessor systems guidelines on system development

    1979-01-01

    The Engineering of Microprocessor Systems: Guidelines on System Development provides economical and technical guidance for use when incorporating microprocessors in products or production processes and assesses the alternatives that are available. This volume is part of Project 0251 undertaken by The Electrical Research Association, which aims to give managers and development engineers advice and comment on the development process and the hardware and software needed to support the engineering of microprocessor systems. The results of Phase 1 of the five-phase project are contained in this fir

  12. A light-powered sub-threshold microprocessor

    Liu Ming; Chen Hong; Zhang Chun; Li Changmeng; Wang Zhihua, E-mail: lium02@mails.tsinghua.edu.cn [Institute of Microelectronics, Tsinghua University, Beijing 100084 (China)

    2010-11-15

    This paper presents an 8-bit sub-threshold microprocessor which can be powered by an integrated photosensitive diode. With a custom designed sub-threshold standard cell library and 1 kbit sub-threshold SRAM design, the leakage power of 58 nW, dynamic power of 385 nW - 165 kHz, EDP 13 pJ/inst and the operating voltage of 350 mV are achieved. Under a light of about 150 kLux, the microprocessor can run at a rate of up to 500 kHz. The microprocessor can be used for wireless-sensor-network nodes.

  13. Leak detection system with distributed microprocessor in the primary containment vessel

    Inahara, K.; Yoshioka, K.; Tomizawa, T.

    1980-01-01

    Responding to the demand for greater improvements of the safety monitoring system, less public radiation exposure, and increase of plant availability, measuring and control systems in nuclear power plants have undergone many improvements. Leak detection systems are also required to give earlier warning, additional accuracy, and continuous monitoring function. This paper describes the drywell sump leakage detection system utilizing a distributed microprocessor, which is a successful application owing to its versatile function and ease of installation. The microprocessor performs various functions such as a rate of level change computation, conversion to leakage flow rate, initiation of alarm, and sump pump control. This system has already been applied to three operating BWR plants that demonstrate its efficiency. (auth)

  14. Use of a microprocessor in the CAMAC standard. The dedicated microcomputer: JCAM-10

    Gallice, Pierre.

    1978-01-01

    The general purpose minicomputers and dedicated crate controllers currently used in small CAMAC systems are now being superseded by autonomous crate controllers with built-in microprocessor such as the JCAM-10, which is in fact a CAMAC dedicated microcomputer. This controller has been designed around the INTEL-8080 microprocessor and employs a semiconductor memory. The very much reduced price and smaller packaging of this module, and the relatively large potential market of CAMAC systems justify the tremendous efforts required for the study of its complete system as well in hardware than in software. After a short description of the CAMAC standard this paper will describe the principle of the microcomputer JCAM-10, and its complementary system: hardware (peripheral modules) and software (TTY command processor, Input Output, Control system, interrupt system, text editor, local macro-assembler, LP and BASICAM local compilers). As application examples, an autonomous counting system and a distributed intelligence system will be described [fr

  15. Microprocessor protection devices: The present and the future

    Gurevich Vladimir

    2008-01-01

    Full Text Available Paper presents the analysis of the basic constructive disadvantages of the present day microprocessor-based protective devices (MBR and offers the basic principles for creating a new MBR that can be used in newly constructed devices.

  16. Evaluation of the performance of microprocessor-based colorimeter

    Randhawa, S. S.; Gupta, R. C.; Bhandari, A. K.; Malhotra, P. S.

    1992-01-01

    Colorimetric estimations have an important role in quantitative studies. An inexpensive and portable microprocessor-based colorimeter developed by the authors is described in this paper. The colorimeter uses a light emitting diode as the light source; a pinphotodiode as the detector and an 8085A microprocessor. Blood urea, glucose, total protein, albumin and bilirubin from patient blood samples were analysed with the instrument and results obtained were compared with assays of the same blood ...

  17. Real time computer system with distributed microprocessors

    Heger, D.; Steusloff, H.; Syrbe, M.

    1979-01-01

    The usual centralized structure of computer systems, especially of process computer systems, cannot sufficiently use the progress of very large-scale integrated semiconductor technology with respect to increasing the reliability and performance and to decreasing the expenses especially of the external periphery. This and the increasing demands on process control systems has led the authors to generally examine the structure of such systems and to adapt it to the new surroundings. Computer systems with distributed, optical fibre-coupled microprocessors allow a very favourable problem-solving with decentralized controlled buslines and functional redundancy with automatic fault diagnosis and reconfiguration. A fit programming system supports these hardware properties: PEARL for multicomputer systems, dynamic loader, processor and network operating system. The necessary design principles for this are proved mainly theoretically and by value analysis. An optimal overall system of this new generation of process control systems was established, supported by results of 2 PDV projects (modular operating systems, input/output colour screen system as control panel), for the purpose of testing by apllying the system for the control of 28 pit furnaces of a steel work. (orig.) [de

  18. Trust versus confidence: Microprocessors and personnel monitoring

    Chiaro, P.J. Jr.

    1993-01-01

    Due to recent technological advances, substantial improvements have been made in personnel contamination monitoring. In all likelihood, these advances will close out the days of manually frisking personnel for radioactive contamination. Unfortunately, as microprocessor-based monitors become more widely used, not only at commercial power reactors but also at government facilities, questions concerning their trustworthiness arise. Algorithms make decisions that were previously made by technicians. Trust is placed not in technicians but in machines. In doing this it is assumed that the machine never misses. Inevitably, this trust drops, due largely to open-quotes false alarms.close quotes This is especially true when monitoring for alpha contamination. What is a open-quotes false alarm?close quotes Do these machines and their algorithms that we put our trust in make mistakes? An analysis was performed on half-body and hand-and-foot monitors at Oak Ridge National Laboratory (ORNL) in order to justify the suggested confidence level used for alarm point determination. Sources used in this analysis had activities approximating ORNL's contamination limits

  19. Trust versus confidence: Microprocessors and personnel monitoring

    Chiaro, P.J. Jr.

    1993-01-01

    Due to recent technological advances, substantial improvements have been made in personnel contamination monitoring. In all likelihood, these advances will close out the days of manually frisking personnel for radioactive contamination. Unfortunately, as microprocessor-based monitors become more widely used, not only at commercial power reactors but also at government facilities, questions concerning their trustworthiness arise. Algorithms make decisions that were previously made by technicians. Trust is placed not in technicians but in machines. In doing this it is assumed that the machine never misses. Inevitably, this trust drops, due largely to ''false alarms''. This is especially true when monitoring for alpha contamination. What is a ''false alarm''? Do these machines and their algorithms that we put our trust in make mistakes? An analysis was performed on half-body and hand-and-foot monitors at Oak Ridge National Laboratory (ORNL) in order to justify the suggested confidence level used for alarm point determination. Sources used in this analysis had activities approximating ORNL's contamination limits

  20. Trust versus confidence: Microprocessors and personnel monitoring

    Chiaro, P.J. Jr.

    1994-01-01

    Due to recent technological advances, substantial improvements have been made in personnel contamination monitoring. In all likelihood, these advances will close out the days of manually frisking personnel for radioactive contamination. Unfortunately, as microprocessor-based monitors become more widely used, not only at commercial power reactors but also at government facilities, questions concerning their trustworthiness arise. Algorithms make decisions that were previously made by technicians. Trust is placed not in technicians but in machines. In doing this it is assumed that the machine never misses. Inevitably, this trust drops, due largely to ''false alarms''. This is especially true when monitoring for alpha contamination. What is a ''false alarm''? Do these machines and their algorithms that they put their trust in make mistakes? An analysis was performed on half-body and hand-and-foot monitors at Oak Ridge National Laboratory (ORNL) in order to justify the suggested confidence level used for alarm point determination. Sources used in this analysis had activities approximating ORNL's contamination limits

  1. Environmental qualification and functional issues for microprocessor-based reactor protection systems

    Korsah, K.; Kisner, R.; Wood, R.T.; Antonescu, C.

    1992-01-01

    Issues of obsolescence and lack of intrastructural support in (analog) spare parts, coupled with the potential benefits of digital systems, are driving the nuclear industry to retrofit analog instrumentation and control (I ampersand C) systems with digital and microprocessor-based systems. This movement away from analog can be expected to increase in advanced light-water reactors (ALWRs), which will make extensive use of fiber optic transmission, multiplexing techniques, and microprocessor-based technology. Although these technologies have several advantages and, in fact, have been in widespread use in the non-nuclear industry for several years, their application to safety-related systems in nuclear power plants raises key issues relating to the systems' environmental and functional reliability. For example, does the new hardware introduce additional system aging degradation mechanisms that could adversely impact the safety of the plant? Do the systems introduce the possibility of new and different malfunction scenarios or increase the probability of common-mode failures that could reduce the reliability of the safety system?. Are current environmental qualification standards adequate for microprocessor-based I ampersand C systems? Accordingly in 1991 the Nuclear Regulatory Commission (NRC) initiated the qualification of advanced Instrumentation and Control Systems program at ORNL to investigate issues that may arise with the use of advanced digital I ampersand C in ALWRs. The results of our studies to date are summarized in this paper

  2. GPS/MEMS IMU/Microprocessor Board for Navigation

    Gender, Thomas K.; Chow, James; Ott, William E.

    2009-01-01

    A miniaturized instrumentation package comprising a (1) Global Positioning System (GPS) receiver, (2) an inertial measurement unit (IMU) consisting largely of surface-micromachined sensors of the microelectromechanical systems (MEMS) type, and (3) a microprocessor, all residing on a single circuit board, is part of the navigation system of a compact robotic spacecraft intended to be released from a larger spacecraft [e.g., the International Space Station (ISS)] for exterior visual inspection of the larger spacecraft. Variants of the package may also be useful in terrestrial collision-detection and -avoidance applications. The navigation solution obtained by integrating the IMU outputs is fed back to a correlator in the GPS receiver to aid in tracking GPS signals. The raw GPS and IMU data are blended in a Kalman filter to obtain an optimal navigation solution, which can be supplemented by range and velocity data obtained by use of (l) a stereoscopic pair of electronic cameras aboard the robotic spacecraft and/or (2) a laser dynamic range imager aboard the ISS. The novelty of the package lies mostly in those aspects of the design of the MEMS IMU that pertain to controlling mechanical resonances and stabilizing scale factors and biases.

  3. Environmental dose measurement with microprocessor based portable TLD reader

    Deme, S.; Apathy, I.; Feher, I.

    1996-01-01

    Application of TL method for environmental gamma-radiation dosimetry involves uncertainty caused by the dose collected during the transport from the point of annealing to the place of exposure and back to the place of evaluation. Should an accident occur read out is delayed due to the need to transport to a laboratory equipped with a TLD reader. A portable reader capable of reading out the TL dosemeter at the place of exposure ('in situ TLD reader') eliminates the above mentioned disadvantages. We have developed a microprocessor based portable TLD reader for monitoring environmental gamma-radiation doses and for on board reading out of doses on space stations. The first version of our portable, battery operated reader (named Pille - 'butterfly') was made at the beginning of the 80s. These devices used CaSO 4 bulb dosemeters and the evaluation technique was based on analogue timing circuits and analogue to digital conversion of the photomultiplier current with a read out precision of 1 μGy and a measuring range up to 10 Gy. The measured values were displayed and manually recorded. The version with an external power supply was used for space dosimetry as an onboard TLD reader

  4. Experience in installing a microprocessor-based protection system on a UK nuclear power plant

    Jones, C.D.; Smith, I.C.

    1993-01-01

    This paper describes a recently completed project to install a microprocessor-based reactor protection system on a twin reactor station in the United Kingdom. This represented the first application of digital technology as part of such a system in the UK. The background of the application and details of the chosen solution are provided. The experience gained during the installation, commissioning and early operation of the equipment is reviewed by the operators. Interactions between the utility and the regulatory body are outlined and the impact of the regulatory process on the utility's resources and the project timescales are discussed

  5. Bilateral C6 spondylolysis with spondylolisthesis in 3 adolescent siblings.

    Kushare, Indranil V; Colo, Dino; Kadhim, Muayad; Dormans, John P

    2014-01-01

    Cervical spondylolysis with spondylolisthesis is a rare condition in the pediatric population. The nature of this condition and clinical presentation are important to provide appropriate management. This is a case report of 3 adolescent siblings who had C6 cervical spondylolysis with spondylolisthesis. Two cases were diagnosed insidiously with absence of neurological deficits and no instability on imaging and were treated conservatively. One case had a traumatic presentation associated with instability on imaging and was managed with cervical fusion and instrumentation. All 3 patients were doing well on a follow-up of >2 years. These cases suggest that cervical spondylolysis could be familial. The treatment was offered based on clinical presentation and presence of instability on radiographic studies. Level IV.

  6. Single event effect testing of the Intel 80386 family and the 80486 microprocessor

    Moran, A.; LaBel, K.; Gates, M.; Seidleck, C.; McGraw, R.; Broida, M.; Firer, J.; Sprehn, S.

    1996-01-01

    The authors present single event effect test results for the Intel 80386 microprocessor, the 80387 coprocessor, the 82380 peripheral device, and on the 80486 microprocessor. Both single event upset and latchup conditions were monitored

  7. Design of microprocessor-based hardware for number theoretic transform implementation

    Anwar Ahmed Shamim

    1985-01-01

    The Winograd (1976) Fourier Transform algorithm (WFTA) was implemented on a TMS9900 microprocessor to compute NTTs. Since multiplication conducted modulo m is very time consuming a special purpose external hardware modular multiplier was designed, constructed and interfaced with the TMS9900 microprocessor. This external hardware modular multiplier allowed an improvement in the transform execution time. Computation time may further be reduced by employing several microprocessors. Taking advantage of the inherent parallelism of the WFTA, a dedicated parallel microprocessor system was designed and constructed to implement a 15-point WFTA in parallel. Benchmark programs were written to choose a suitable microprocessor for the parallel microprocessor system. A master or a host microprocessor is used to control the parallel microprocessor system and provides an interface to the outside world. An analogue to digital (a/d) and a digital to analogue (d/a) converter allows real time digital signal processing.

  8. Microprocessor-based data acquisition systems for Hera experiments

    Haynes, W.J.

    1989-09-01

    Sophisticated multi-microprocessor configurations are envisaged to cope with the technical challenges of the HERA electron-proton collider and the high data rates from the two large experiments H1 and ZEUS. These lecture notes concentrate on many of the techniques employed, with much emphasis being placed on the use of the IEEE standard VMEbus as a unifying element. The role of modern 32-bit CISC and RISC microprocessors, in the handling of data and the filtering of physics information, is highlighted together with the integration of personal computer stations for monitoring and control. (author)

  9. Cross software for microprocessor program development at CERN

    Eicken, H. von; Montuelle, J.; Willers, I.; Blake, J.

    1981-01-01

    Programs for a variety of microprocessors (including Intel 8080; Motorola 6800 and 6809 and 68000; and Texas Instruments 9900) can be prepared on different host computers (such as IBM 370, CDC 6000, and Nord 10) using portable programs developed at CERN. The range of cross software consists of: an assembler for each target microprocessor, a single linkage editor, a single object module librarian, and a variety of pre-loaders which convert object modules from CERN's format (CUFOM) into manufacturers' formats. The programs are written in BCPL and PASCAL, programming languages which are available on a wide range of computers. (orig.)

  10. Evaluation of the performance of microprocessor-based colorimeter.

    Randhawa, S S; Gupta, R C; Bhandari, A K; Malhotra, P S

    1992-01-01

    Colorimetric estimations have an important role in quantitative studies. An inexpensive and portable microprocessor-based colorimeter developed by the authors is described in this paper. The colorimeter uses a light emitting diode as the light source; a pinphotodiode as the detector and an 8085A microprocessor. Blood urea, glucose, total protein, albumin and bilirubin from patient blood samples were analysed with the instrument and results obtained were compared with assays of the same blood using a Spectronic 21. A good correlation was found between the results from the two instruments.

  11. CFD-simulation of radiator for air cooling of microprocessors in a limitided space

    Trofimov V. E.; Pavlov A. L.; Mokrousova E. A.

    2016-01-01

    One of the final stages of microprocessors development is heat test. This procedure is performed on a special stand, the main element of which is the switching PCB with one or more mounted microprocessor sockets, chipsets, interfaces, jumpers and other components which provide various modes of microprocessor operation. The temperature of microprocessor housing is typically changed using thermoelectric module. The cold surface of the module with controlled temperature is in direct thermal c...

  12. Cytochrome c6B of Synechococcus sp. WH 8102 – Crystal structure and basic properties of novel c6-like family representative

    Zatwarnicki, Pawel; Barciszewski, Jakub; Krzywda, Szymon; Jaskolski, Mariusz; Kolesinski, Piotr; Szczepaniak, Andrzej

    2014-01-01

    Highlights: • Crystal structure of cytochrome c 6B from Synechococcus sp. WH 8102 was solved. • Basic biophysical properties of cytochrome c 6B were determined. • Cytochrome c 6B exhibits similar architecture to cytochrome c 6 . • Organization of heme binding pocket of cytochrome c 6B differs from that of c 6 . • Midpoint potential of cytochrome c 6B is significantly lower than of cytochrome c 6 . - Abstract: Cytochromes c are soluble electron carriers of relatively low molecular weight, containing single heme moiety. In cyanobacteria cytochrome c 6 participates in electron transfer from cytochrome b 6 f complex to photosystem I. Recent phylogenetic analysis revealed the existence of a few families of proteins homologous to the previously mentioned. Cytochrome c 6A from Arabidopsis thaliana was identified as a protein responsible for disulfide bond formation in response to intracellular redox state changes and c 550 is well known element of photosystem II. However, function of cytochromes marked as c 6B , c 6C and c M as well as the physiological process in which they take a part still remain unidentified. Here we present the first structural and biophysical analysis of cytochrome from the c 6B family from mesophilic cyanobacteria Synechococcus sp. WH 8102. Purified protein was crystallized and its structure was refined at 1.4 Å resolution. Overall architecture of this polypeptide resembles typical I-class cytochromes c. The main features, that distinguish described protein from cytochrome c 6 , are slightly red-shifted α band of UV–Vis spectrum as well as relatively low midpoint potential (113.2 ± 2.2 mV). Although, physiological function of cytochrome c 6B has yet to be determined its properties probably exclude the participation of this protein in electron trafficking between b 6 f complex and photosystem I

  13. Data acquisition and command system for use with a microprocessor-based control chassis

    Halbig, J.K.; Klosterbuer, S.F.; Martinez, V.A. Jr.

    1980-01-01

    The Pion Generation for Medical Irradiations (PIGMI) program at the Los Alamos Scientific Laboratory is developing the technology to build smaller, less expensive, and more reliable proton linear accelerators for medical applications, and has designed a powerful, simple, inexpensive, and reliable control and data acquisition system that is central to the program development. The system is a NOVA-3D minicomputer interfaced to several outlying microprocessor-based controllers, which accomplish control and data acquisition through data I/O chasis. The equipment interface chassis, which can issue binary commands, read binary data, issue analog commands, and read timed and untimed analog data is described

  14. Development of a microprocessor controller for stand-alone photovoltaic power systems

    Millner, A. R.; Kaufman, D. L.

    1984-01-01

    A controller for stand-alone photovoltaic systems has been developed using a low power CMOS microprocessor. It performs battery state of charge estimation, array control, load management, instrumentation, automatic testing, and communications functions. Array control options are sequential subarray switching and maximum power control. A calculator keypad and LCD display provides manual control, fault diagnosis and digital multimeter functions. An RS-232 port provides data logging or remote control capability. A prototype 5 kW unit has been built and tested successfully. The controller is expected to be useful in village photovoltaic power systems, large solar water pumping installations, and other battery management applications.

  15. Digital Fractional Order Controllers Realized by PIC Microprocessor: Experimental Results

    Petras, I.; Grega, S.; Dorcak, L.

    2003-01-01

    This paper deals with the fractional-order controllers and their possible hardware realization based on PIC microprocessor and numerical algorithm coded in PIC Basic. The mathematical description of the digital fractional -order controllers and approximation in the discrete domain are presented. An example of realization of the particular case of digital fractional-order PID controller is shown and described.

  16. Design and implementation of a microprocessor based room ...

    This paper describes the development of a microprocessor based room illumination control system that offers advantage of improved efficiency in the use of electrical energy and reduced cost of electricity over manually controlled lighting systems. This system is developed to regulate the intensity of light from direct current ...

  17. Architecture of 32 bit CISC (Complex Instruction Set Computer) microprocessors

    Jove, T.M.; Ayguade, E.; Valero, M.

    1988-01-01

    In this paper we describe the main topics about the architecture of the best known 32-bit CISC microprocessors; i80386, MC68000 family, NS32000 series and Z80000. We focus on the high level languages support, operating system design facilities, memory management, techniques to speed up the overall performance and program debugging facilities. (Author)

  18. Small private key MQPKS on an embedded microprocessor.

    Seo, Hwajeong; Kim, Jihyun; Choi, Jongseok; Park, Taehwan; Liu, Zhe; Kim, Howon

    2014-03-19

    Multivariate quadratic (MQ) cryptography requires the use of long public and private keys to ensure a sufficient security level, but this is not favorable to embedded systems, which have limited system resources. Recently, various approaches to MQ cryptography using reduced public keys have been studied. As a result of this, at CHES2011 (Cryptographic Hardware and Embedded Systems, 2011), a small public key MQ scheme, was proposed, and its feasible implementation on an embedded microprocessor was reported at CHES2012. However, the implementation of a small private key MQ scheme was not reported. For efficient implementation, random number generators can contribute to reduce the key size, but the cost of using a random number generator is much more complex than computing MQ on modern microprocessors. Therefore, no feasible results have been reported on embedded microprocessors. In this paper, we propose a feasible implementation on embedded microprocessors for a small private key MQ scheme using a pseudo-random number generator and hash function based on a block-cipher exploiting a hardware Advanced Encryption Standard (AES) accelerator. To speed up the performance, we apply various implementation methods, including parallel computation, on-the-fly computation, optimized logarithm representation, vinegar monomials and assembly programming. The proposed method reduces the private key size by about 99.9% and boosts signature generation and verification by 5.78% and 12.19% than previous results in CHES2012.

  19. Small Private Key MQPKS on an Embedded Microprocessor

    Hwajeong Seo

    2014-03-01

    Full Text Available Multivariate quadratic (MQ cryptography requires the use of long public and private keys to ensure a sufficient security level, but this is not favorable to embedded systems, which have limited system resources. Recently, various approaches to MQ cryptography using reduced public keys have been studied. As a result of this, at CHES2011 (Cryptographic Hardware and Embedded Systems, 2011, a small public key MQ scheme, was proposed, and its feasible implementation on an embedded microprocessor was reported at CHES2012. However, the implementation of a small private key MQ scheme was not reported. For efficient implementation, random number generators can contribute to reduce the key size, but the cost of using a random number generator is much more complex than computing MQ on modern microprocessors. Therefore, no feasible results have been reported on embedded microprocessors. In this paper, we propose a feasible implementation on embedded microprocessors for a small private key MQ scheme using a pseudo-random number generator and hash function based on a block-cipher exploiting a hardware Advanced Encryption Standard (AES accelerator. To speed up the performance, we apply various implementation methods, including parallel computation, on-the-fly computation, optimized logarithm representation, vinegar monomials and assembly programming. The proposed method reduces the private key size by about 99.9% and boosts signature generation and verification by 5.78% and 12.19% than previous results in CHES2012.

  20. Small Private Key PKS on an Embedded Microprocessor

    Seo, Hwajeong; Kim, Jihyun; Choi, Jongseok; Park, Taehwan; Liu, Zhe; Kim, Howon

    2014-01-01

    Multivariate quadratic ( ) cryptography requires the use of long public and private keys to ensure a sufficient security level, but this is not favorable to embedded systems, which have limited system resources. Recently, various approaches to cryptography using reduced public keys have been studied. As a result of this, at CHES2011 (Cryptographic Hardware and Embedded Systems, 2011), a small public key scheme, was proposed, and its feasible implementation on an embedded microprocessor was reported at CHES2012. However, the implementation of a small private key scheme was not reported. For efficient implementation, random number generators can contribute to reduce the key size, but the cost of using a random number generator is much more complex than computing on modern microprocessors. Therefore, no feasible results have been reported on embedded microprocessors. In this paper, we propose a feasible implementation on embedded microprocessors for a small private key scheme using a pseudo-random number generator and hash function based on a block-cipher exploiting a hardware Advanced Encryption Standard (AES) accelerator. To speed up the performance, we apply various implementation methods, including parallel computation, on-the-fly computation, optimized logarithm representation, vinegar monomials and assembly programming. The proposed method reduces the private key size by about 99.9% and boosts signature generation and verification by 5.78% and 12.19% than previous results in CHES2012. PMID:24651722

  1. Use of a microprocessor in a remote working level monitor

    Keffe, D.J.; McDowell, W.P.; Groer, P.G.

    1975-01-01

    A remote working level monitor was designed to measure short-lived radon-daughter concentrations in sealed chambers having potentially high radiation levels (up to 2000 WL). The system is comprised of surface barrier detectors, multiplexer and buffers, microprocessor and teletype

  2. Microprocessor controlled dual parameter ADC system with a CAMAC interface

    Perry, D G; Nickell, Jr, J D [Los Alamos Scientific Lab., NM (USA)

    1978-09-01

    Presented here is the design of a dual parameter ADC system which is controlled by a microprocessor and also interfaced to CAMAC. The system was designed to be mobile in that it may work wherever there is a CAMAC crate. In such cases where the CAMAC system is inoperative, the system may operate in a stand-alone mode.

  3. The Microprocessor controls the activity of mammalian retrotransposons

    Heras, Sara R.; Macias, Sara; Plass, Mireya

    2013-01-01

    RNA biogenesis, also recognizes and binds RNAs derived from human long interspersed element 1 (LINE-1), Alu and SVA retrotransposons. Expression analyses demonstrate that cells lacking a functional Microprocessor accumulate LINE-1 mRNA and encoded proteins. Furthermore, we show that structured regions...

  4. A microprocessor based multiscaling data acquisition system for moessbauer spectroscopy

    Bohm, C.; Ekdahl, T.

    1985-01-01

    A microprocessor based data acquisition system is described, which was developed for use in Moessbauer spectroscopy. It is designed to record two spectra simultaneously, one of which could be a calibration spectrum. It is autonomous, but uses a host computer for initialization and permanent storage of data. The host communication software is also described. (Author)

  5. Real-time fetal ECG system design using embedded microprocessors

    Meyer-Baese, Uwe; Muddu, Harikrishna; Schinhaerl, Sebastian; Kumm, Martin; Zipf, Peter

    2016-05-01

    The emphasis of this project lies in the development and evaluation of new robust and high fidelity fetal electrocardiogram (FECG) systems to determine the fetal heart rate (FHR). Recently several powerful algorithms have been suggested to improve the FECG fidelity. Until now it is unknown if these algorithms allow a real-time processing, can be used in mobile systems (low power), and which algorithm produces the best error rate for a given system configuration. In this work we have developed high performance, low power microprocessor-based biomedical systems that allow a fair comparison of proposed, state-of-the-art FECG algorithms. We will evaluate different soft-core microprocessors and compare these solutions to other commercial off-the-shelf (COTS) hardcore solutions in terms of price, size, power, and speed.

  6. Design and Implementation of O/C relay using Microprocessor

    Dr.Abdul-Sattar H. Jasim

    2012-03-01

    Full Text Available This work presents the design and implementation of a versatile digital overcurrent (O/C relay using a single microprocessor. The relay is implemented by a combination of a look-up table and a counter. The software development and hardware testing are done using a microcomputer module based on a 8-bit microprocessor. The digital processing of measured currents enables a separate setting of operating values selection of all types of inverse or constant time characteristics overcurrent protection. This protection provides reasonably fast tripping, even at terminal close to the power source were the most serve faults can occur excluding the transient condition. So this method has an excellent compromise between accuracy hardware and speed

  7. Microprocessor event analysis in parallel with Camac data acquisition

    Cords, D.; Eichler, R.; Riege, H.

    1981-01-01

    The Plessey MIPROC-16 microprocessor (16 bits, 250 ns execution time) has been connected to a Camac System (GEC-ELLIOTT System Crate) and shares the Camac access with a Nord-1OS computer. Interfaces have been designed and tested for execution of Camac cycles, communication with the Nord-1OS computer and DMA-transfer from Camac to the MIPROC-16 memory. The system is used in the JADE data-acquisition-system at PETRA where it receives the data from the detector in parallel with the Nord-1OS computer via DMA through the indirect-data-channel mode. The microprocessor performs an on-line analysis of events and the result of various checks is appended to the event. In case of spurious triggers or clear beam gas events, the Nord-1OS buffer will be reset and the event omitted from further processing. (orig.)

  8. Microprocessor event analysis in parallel with CAMAC data acquisition

    Cords, D; Riege, H

    1981-01-01

    The Plessey MIPROC-16 microprocessor (16 bits, 250 ns execution time) has been connected to a CAMAC System (GEC-ELLIOTT System Crate) and shares the CAMAC access with a Nord-10S computer. Interfaces have been designed and tested for execution of CAMAC cycles, communication with the Nord-10S computer and DMA-transfer from CAMAC to the MIPROC-16 memory. The system is used in the JADE data-acquisition-system at PETRA where it receives the data from the detector in parallel with the Nord-10S computer via DMA through the indirect-data-channel mode. The microprocessor performs an on-line analysis of events and the results of various checks is appended to the event. In case of spurious triggers or clear beam gas events, the Nord-10S buffer will be reset and the event omitted from further processing. (5 refs).

  9. Small Private Key PKS on an Embedded Microprocessor

    Seo, Hwajeong; Kim, Jihyun; Choi, Jongseok; Park, Taehwan; Liu, Zhe; Kim, Howon

    2014-01-01

    Multivariate quadratic (MQ) cryptography requires the use of long public and private keys to ensure a sufficient security level, but this is not favorable to embedded systems, which have limited system resources. Recently, various approaches to MQ cryptography using reduced public keys have been studied. As a result of this, at CHES2011 (Cryptographic Hardware and Embedded Systems, 2011), a small public key MQ scheme, was proposed, and its feasible implementation on an embedded microprocessor...

  10. Overview of real-time operating systems on microprocessor platforms

    Luong, T.T.

    1994-01-01

    This paper attempts to overview the real-time operating systems on microprocessor platforms in the field of experimental physics facility controls. The key issues regarding operating systems as well as standards and development environment are discussed. As an illustration, some current industrial products are indicated. Also, real-time systems operating in some institutes of the EPS/EPCS inter divisional group are reviewed. (author). 3 refs., 4 figs

  11. Design analysis and microprocessor based control of a nuclear reactor

    Sabbakh, N.J.

    1988-01-01

    The object of this thesis is to design and test a microprocessor based controller, to a simulated nuclear reactor system. The mathematical model that describes the dynamics of a typical nuclear reactor of one group of delayed neutrons approximations with temperature feedback was chosen. A digital computer program has been developed for the design and analysis of a simulated model based on the concept of state-variable feedback in order to meet a desired system response with maximum overshoot of 3.4% and setting time of 4 sec. The state variable feedback coefficients are designed for the continuous system, then an approximation is used to obtain in the state variable feedback vector for the discrete system. System control was implemented utilizing Direct Digital Control (DDC) of a nuclear reactor simulated model through a control algorithm that was performed by means of a microprocessor based system. The controller performance was satisfactorily tested by exciting the reactor system with a transient reactivity disturbance and by a step change in power demand. Direct digital control, when implemented on a microprocessor adds versatility, flexibility in system design with the added advantage of possible use of optimal control algorithms. 6 tabs.; 30 figs.; 46 refs.; 6 apps

  12. Radiolabeling and animal experimental studies of anti-breast cancer McAb 6C6 and mouse-human chimeric antibody 6C6CHI

    Yang Zhi; Hu Xiaoqian; Li Erqiu

    2003-01-01

    The aim of this work is to study bio-distribution and tumor absorption of anti breast cancer monoclonal antibody 6C6 and its chimeric antibody 6C6-CHI. The modified Schwartz method was employed to label 6C6 and 6C6CHI with 99 Tc m . The labeled antibody was injected to mouse via tail vein and the blood clearance and whole body clearance were observed. Nude mice bearing breast cancer MCF7 were injected with 99 Tc m -labeled antibody and the bio-distribution was studied and imaged with γ-ray camera. The yield of the two labeled antibodies was more than 90% and their immunoactivities were more than 80%. The whole body eliminated half-time of 99 Tc m -6C6 was 4.1h, and the half-times in blood were T α =0.55h and T β =12.42h respectively. The whole body half-time of 99 Tc m -6C6CHI was 4.28h and the half-times in blood were T α =0.98h and T β =12.42h respectively. The bio-distribution of nude mice bearing breast cancer MCF7 cells was as follows: the ID%/g of tumor and blood was (7.42±0.85) and (5.67±1.44) respectively at 23h after injection of 99 Tc m -6C6. The T/NT (tumor to non tumor) ratios were all more than 1.0 except kidney and the ID%/g of tumor and blood was (4.23±0.64) and (6.97±0.23) respectively at 23 h after injection of 99 Tc m -6C6CHI. The T/NT (tumor to non tumor) ratios were all more than 1.0 except blood and kidney. The γ imaging results showed that the tumor was imaged clearly at 24h after injection of radiolabeled antibodies and the other organs did not concentrate the antibodies except kidney. Anti-breast cancer monoclonal antibody 6C6 can be well located in tumor. Although ID%/g of tumor of the chimeric antibody 6C6CHI was slightly lower than that of 6C6 antibody, and ID%/g of blood was higher than that of 6C6, the tumor imaging of 6C6-CHI was also clear

  13. Production of lactic acid from C6-polyols by alkaline hydrothermal reactions

    Zhou Huazhen; Jin Fangming; Wu Bing; Cao Jianglin; Duan Xiaokun; Kishita, Atsushi

    2010-01-01

    Production of lactic acid from C6-polyols (Mannitol) under alkaline hydrothermal conditions was investigated. Experiments were performed to examine the difference in the production of lactic acid between C6-polyols and C3-polyols (glycerine), as well as C6-aldoses (glucose). Results showed that the yield of lactic acid from C6-polyols was lower than that from both glycerine and glucose. It indicated that long chain polyols might follow a different reaction pathway from that of glycerine. Further investigation is needed to clarify the reaction mechanism and improve the relatively low lactic acid acid yield from C6-polyols.

  14. Advances in Sensors-Centric Microprocessors and System-on-Chip

    Juan A. Gómez-Pulido

    2012-04-01

    Full Text Available Sensors-based systems are nowadays an extended technology for many markets due to their great potential in the collection of data from the environment and the processing of such data for different purposes. A typical example is the wireless sensor devices, where the outer temperature, humidity, luminosity and many other parameters can be acquired, measured and processed in order to build useful and fascinating applications that contribute to human welfare. In this scenario, the processing architectures of the sensors-based systems play a very important role. The requirements that are necessary for many such applications (real-time processing, low-power consumption, reduced size, reliability, security and many others means that research on advanced architectures of Microprocessors and System-on-Chips (SoC is needed to design and implement a successful product. In this sense, there are many challenges and open questions in this area that need to be addressed. [...

  15. Chimeric anti-tenascin antibody 81C6: Increased tumor localization compared with its murine parent

    Zalutsky, Michael R.; Archer, Gary E.; Garg, Pradeep K.; Batra, Surinder K.; Bigner, Darell D.

    1996-01-01

    When labeled using the Iodogen method, a chimeric antibody composed of the human IgG 2 constant region and the variable regions of murine anti-tenascin 81C6 exhibited superior uptake in human glioma xenografts compared with its murine parent. In the current study, three paired-label experiments were performed in athymic mice with subcutaneous D-54 MG human glioma xenografts to evaluate further the properties of radioiodinated chimeric 81C6. These studies demonstrated that (a) the enhanced tumor uptake of chimeric 81C6 is specific; (b) when labeling was performed using N-succinimidyl 3-iodobenzoate, chimeric 81C6 again showed preferential accumulation in tumor compared with murine 81C6; and (c) the tumor uptake advantage observed previously with murine 81C6 for N-succinimidyl 3-iodobenzoate compared with Iodogen labeling did not occur with chimeric 81C6

  16. A Methodology for Formal Hardware Verification, with Application to Microprocessors.

    1993-08-29

    concurrent programming lan- guages. Proceedings of the NATO Advanced Study Institute on Logics and Models of Concurrent Systems ( Colle - sur - Loup , France, 8-19...restricted class of formu- las . Bose and Fisher [26] developed a symbolic model checker based on a Cosmos switch-level model. Their modeling approach...verification using SDVS-the method and a case study. 17th Anuual Microprogramming Workshop (New Orleans, LA , 30 October-2 November 1984). Published as

  17. Simultaneous occurrence of hereditary C6 and C2 deficiency in a French-Canadian family.

    Delâge, J M; Lehner-Netsch, G; Lafleur, R; Simard, J; Brun, G; Prochazka, E

    1979-06-01

    The sera of four sisters were found to lack the sixth component of complement (C6) and the serum of one was also partially deficient in the second component (C2). Two other blood relatives were found to be heterozygous for both deficiencies, while only one sibling had normal values. The father of these eight siblings was heterozygous for C2D and C6D and in the third generation, six children were heterozygous for C6 deficiency was treated for chronic active brucel-transmitted; the C6 deficiency was not linked to the HLA system, while the C2-deficiency segregated with the haplotype A10,B18. The proband, homozygous for C6 deficiency was treated for chronic active Brucellosis and in another sibling with C6 deficiency, toxoplasmosis was diagnosed. Neither bleeding disorders nor a tendency to collagen diseases have been observed and the opsonic activity was normal in the sera of all family members.

  18. Unified microprocessor CAMAC module for preliminary data processing

    Zaushitsin, V.L.; Kulik, O.V.; Repin, V.M.

    1984-01-01

    The UP-80 unified active module is described. It is made in the CAMAC standard on the base of the K580IK80 microprocessor allowing to increase the rate of large-volume experimental spectroscopic data processing by an order. Loading of 5 different programs for data processing is possible. Data from the operative storage with 1K capacity (8 bits) are recorded and read out trhough the CAMAC line (the regime of unit exchange is possible) or through the joint of the external line

  19. Practical design of digital circuits basic logic to microprocessors

    Kampel, Ian

    1983-01-01

    Practical Design of Digital Circuits: Basic Logic to Microprocessors demonstrates the practical aspects of digital circuit design. The intention is to give the reader sufficient confidence to embark upon his own design projects utilizing digital integrated circuits as soon as possible. The book is organized into three parts. Part 1 teaches the basic principles of practical design, and introduces the designer to his """"tools"""" - or rather, the range of devices that can be called upon. Part 2 shows the designer how to put these together into viable designs. It includes two detailed descriptio

  20. A fastbus master based on a risc microprocessor

    Cerrito, L.; Chorowicz, V.; Lebbolo, H.; Vallereau, A.

    1990-01-01

    SISIFUS is a general purpose Fastbus Master and Slave able to perform any operation on both Fastbus segments. Master operations are directed either by the processor or by two fast sequencers. A Block Mover function is implemented allowing direct data block transfers between two Slaves. SISIFUS uses the AM 29000 RISC microprocessor which can execute every assembler instruction in 40ns. The on-board monitor/debugger allows programs to be written in assembler from a terminal connected to the module or written in C and cross compiled on a host computer (PC)

  1. Use of a microprocessor in a remote working level monitor

    Keefe, D.J.; McDowell, W.P.; Groer, P.G.

    1976-01-01

    The instrument described measures the short-lived 222 Rn-daughter concentrations and the Working Level (WL) in sealed ''hot chambers'' located in uranium mines. Radiation-induced pulses from two separate sensors are transmitted through 500 ft. cables to a microprocessor, which processes the pulses and controls the operation of the system. A read-only memory stores a fixed program which is used to calculate the desired concentrations. The results are printed as pCi/l (Rn-daughter concentrations) and WL

  2. Microprocessor-assisted calibration for a remote working level monitor

    McDowell, W.P.; Keefe, D.J.; Groer, P.G.; Witek, R.T.

    1977-01-01

    A method is described for calibrating a Remote Working Level Monitor, an instrument which measures Working Level and Rn-daughter concentrations in the atmosphere. The method makes use of a microprocessor to calculate beta efficiencies for RaB and RaC from the counts accumulated in the RaA, Ra(B + C) and RaC' channels of the instrument. Both the alpha spectroscopic and total-alpha methods are used to determine the Rn-daughter concentrations. These methods require the processor to solve systems of linear equations with several unknowns. No assumptions about Rn-daughter equilibrium are made

  3. Microprocessor-assisted calibration for a remote working level monitor

    McDowell, W.P.; Keefe, D.J.; Groer, P.G.; Witek, R.T.

    1976-01-01

    A method is described for calibrating a Remote Working Level Monitor, an instrument which measures Working Level and Rn-daughter concentrations in the atmosphere. The method makes use of a microprocessor to calculate beta efficiencies for RaB and RaC from the counts accumulated in the RaA, Ra(B + C) and RaC' channels of the instrument. Both the alpha spectroscopic and total-alpha methods are used to determine the Rn-daughter concentrations. These methods require the processor to solve systems of linear equations with several unknowns. No assumptions about Rn-daughter equilibrium are made

  4. Microprocessor Control Design for a Low-Head Crossflow Turbine.

    1985-03-01

    Controllers For a Typical 10 KW Hydroturbine ............ 1-5 I-1 Ely’s Crossflow Turbine . ........ 11-2 11-2 Basic Turbine * * 0 * 0 11-5 11-3 Turbine...the systems. For example, a 25 kilowatt hydroturbine built and installed by Bell Hydroelectric would cost approximately $20,000 in 1978 (6:49). The...O Manual Controller S2 E- Microprocessor Controller 1 2 3 4 5 6 7 8 YEARS Fig. 1-2 Comparative Costs of Controllers For a Typical 10 KW Hydroturbine

  5. Microprocessor based beam loss monitor system for the AGS

    Witkover, R.L.

    1979-01-01

    An array of 120 long radiation monitors (LRM) have been installed around the AGS. Each monitor is an extended coaxial ion chamber, 5 meters long, made from hollow core coaxial transmission cable pressured with argon. The LRM's are each connected to a low current preamplifier and voltage-to-frequency converter (VFC). The digital output of each channel is fed to a 16 bit counter chip which bridges the bus of an 8085 microprocessor. This circuit is connected to the AGS PD-10 for data taking or may function as a stand-alone unit. Various operating modes can be selected for data readout. System design and operating performance are described

  6. A CAMAC-resident microprocessor used for field control of a dipole magnet

    Sharp, F.J.; Greiner, B.F.

    1990-01-01

    An inexpensive, self-contained microprocessor supporting an on-chip BASIC interpreter has been incorporated into a CAMAC auxiliary-crate controller, with an EEPROM and a terminal port. Used with an ASCII computer terminal, the intelligent auxiliary controller is a self-contained program-development system. One application for the intelligent auxiliary controller is closed-loop control of the analyzing dipoles at the negative-ion injector of the TASCC (tandem accelerator superconducting cyclotron) heavy-ion accelerators. A BASIC program stored in the EEPROM runs on power-up of the controller. The program reads control numbers from a CAMAC mailbox, converts the ASCII character string from a precision Hall-probe teslameter to a digital field reading, and writes a control number to the dipole controller. The program iterates until the dipole reaches the demand field, while updating another CAMAC mailbox with a field readback for the main control system. (orig.)

  7. A Low Cost Matching Motion Estimation Sensor Based on the NIOS II Microprocessor

    Diego González

    2012-09-01

    Full Text Available This work presents the implementation of a matching-based motion estimation sensor on a Field Programmable Gate Array (FPGA and NIOS II microprocessor applying a C to Hardware (C2H acceleration paradigm. The design, which involves several matching algorithms, is mapped using Very Large Scale Integration (VLSI technology. These algorithms, as well as the hardware implementation, are presented here together with an extensive analysis of the resources needed and the throughput obtained. The developed low-cost system is practical for real-time throughput and reduced power consumption and is useful in robotic applications, such as tracking, navigation using an unmanned vehicle, or as part of a more complex system.

  8. Draft Genome Sequence of Acinetobacter johnsonii C6, an Environmental Isolate Engaging in Interspecific Metabolic Interactions

    Kaas, Rolf Sommer; Mordhorst, Hanne; Leekitcharoenphon, Pimlapas

    2017-01-01

    Acinetobacter johnsonii C6 originates from creosote-polluted groundwater and performs ecological and evolutionary interactions with Pseudomonas putida in biofilms. The draft genome of A. johnsonii C6 is 3.7 Mbp and was shaped by mobile genetic elements. It reveals genes facilitating the biodegrad......Acinetobacter johnsonii C6 originates from creosote-polluted groundwater and performs ecological and evolutionary interactions with Pseudomonas putida in biofilms. The draft genome of A. johnsonii C6 is 3.7 Mbp and was shaped by mobile genetic elements. It reveals genes facilitating...

  9. Synthesis and characterization of [Ru(η6-C6Me6)Cl2(CNPy)] and [Cl2(η6-C6Me6)Ru-(μ-CNPy)-Ru(η6-C6Me6)Cl2] and reactivity of [Ru(η6-C6Me6)Cl2(CNPy)] with various bases

    Pandey, D.S.; Sahay, A.N.; Agarwala, U.C.

    1996-01-01

    Reactions of [(Ru(η 6 -C 6 Me 6 )Cl 2 ) 2 ] with 4-cyanopyridine leads to the formation of neutral mono and dimeric complexes viz., [Ru(η 6 C 6 Me 6 )Cl 2 (CNPy)] (I) and [Cl 2 (η 6 -C 6 Me 6 ) Ru-(μ-CNPy)-Ru(η 6 -C 6 Me 6 )Cl 2 ] (II). Complex (I) undergoes metathetical reactions with EPh 3 (E=P, As and Sb) and N-donor heterocyclic bases yielding corresponding substitutional products which have been characterized by elemental analyses and spectroscopic: (IR, UV/vis, 1 H and 13 C NMR) studies. (author). 21 refs., 1 tab

  10. Microprocessor system to recover data from a self-scanning photodiode array

    Koppel, L.N.; Gadd, T.J.

    1975-01-01

    A microprocessor system developed at Lawrence Livermore Laboratory has expedited the recovery of data describing the low energy x-ray spectra radiated by laser-fusion targets. An Intel microprocessor controls the digitization and scanning of the data stream of an x-ray-sensitive self-scanning photodiode array incorporated in a crystal diffraction spectrometer

  11. High-speed multiple-channel analog to digital data-acquisition module for microprocessor systems

    Ethridge, C.D.

    1977-01-01

    Intelligent data acquisition and instrumentation systems established by the incorporation of microprocessor technology require high-speed analog to digital conversion of multiple-channel input signals. Sophisticated data systems or subsystems are enabled by the microprocessor software flexibility to establish adaptive input data procedures. These adaptive procedures are enhanced by versatile interface circuitry which is software controlled

  12. Short-chain C6 ceramide sensitizes AT406-induced anti-pancreatic cancer cell activity

    Zhao, Xiaoguang; Sun, Baoyou; Zhang, Jingjing; Zhang, Ruishen; Zhang, Qing

    2016-01-01

    Our previous study has shown that AT406, a first-in-class small molecular antagonist of IAPs (inhibitor of apoptosis proteins), inhibits pancreatic cancer cell proliferation in vitro and in vivo. The aim of this research is to increase AT406's sensitivity by adding short-chain C6 ceramide. We show that co-treatment of C6 ceramide dramatically potentiated AT406-induced caspase/apoptosis activation and cytotoxicity in established (Panc-1 and Mia-PaCa-2 lines) and primary human pancreatic cancer cells. Reversely, caspase inhibitors largely attenuated C6 ceramide plus AT406-induced above cancer cell death. Molecularly, C6 ceramide downregulated Bcl-2 to increase AT406's sensitivity in pancreatic cancer cells. Intriguingly, C6 ceramide-mediated AT406 sensitization was nullified with Bcl-2 shRNA knockdown or pretreatment of the Bcl-2 inhibitor ABT-737. In vivo, liposomal C6 ceramide plus AT406 co-administration dramatically inhibited Panc-1 xenograft tumor growth in severe combined immunodeficient (SCID) mice. The combined anti-tumor activity was significantly more potent than either single treatment. Expressions of IAPs (cIAP1/XIAP) and Bcl-2 were downregulated in Panc-1 xenografts with the co-administration. Together, we demonstrate that C6 ceramide sensitizes AT406-mediated anti-pancreatic cancer cell activity possibly via downregulating Bcl-2. - Highlights: • C6 ceramide dramatically potentiates AT406-induced pancreatic cancer cell death. • C6 ceramide facilitates AT406-induced pancreatic cancer cell apoptosis. • C6 ceramide downregulates Bcl-2 to increase AT406's sensitivity in pancreatic cancer cells. • Liposomal C6 ceramide enhances AT406-induced anti-pancreatic cancer activity in vivo.

  13. High speed serial link for UA1 microprocessor network

    Cittolin, S; Zurfluh, E

    1981-01-01

    The UA1 data acquisition system consists of a set of distributed microprocessor units. An interprocessor link, independent of the CAMAC data readout, has been developed in order to have continuous remote control and run-time data handling, e.g. transmission of calibration programs/parameters, equipment test/status and histogram accumulation. The data transmission system is designed to be used in a loop configuration equipped with transceivers for twisted pair cables (RS-422). As an economical system, it is running as an ancillary serial loop-link between microprocessors, like Data Acquisition Crate Controllers and systems with distributed intelligence. The software driver consists of a loop-controller package, which may run in a BAMBI Computer Language environment and a fully interrupt controlled program for all other secondary stations. A special single-character mode provides a handy link for remote debugging in a pseudo-full-duplex mode. The format is based on the HDLC protocol without sequence numbering. ...

  14. High speed serial link for UA1 microprocessor network

    Cittolin, S.; Loefstedt, B.; Zurfluh, E.

    1981-01-01

    The UA1 data acquisition system consists of a set of distributed microprocessor units. An interprocessor link, independent of the CAMAC data readout, has been developed in order to have continuous remote control and run-time data handling, e.g. transmission of calibration programs/parameters, equipment rest/status and histogram accumulation. The data transmission system is designed to be used in a loop configuration equipped with transceivers for twisted pair cables (RS-422). As an economical system it is running as an ancillary serial loop-link between microprocessors Like Data Acquisition Crate Controllers and systems with distributed intelligence. The software driver consists of a loop-controller package, which may run in a BAMBI Computer Language environment and a fully interrupt controlled program for all other secondary stations. A special single-character mode provides a handy link for remote debugging in a pseudo-full-duplex mode. The format is based on the HDLC protocol without sequence numbering. The Chip MC-6854 from Motorola, Inc. enables an implementation with few components. (orig.)

  15. High speed serial link for UA1 microprocessor network

    Cittolin, Sergio; Zurfluh, E

    1981-01-01

    The UA1 data acquisition system consists of a set of distributed microprocessor units. An interprocessor link, independent of the CAMAC data readout, has been developed in order to have continuous remote control and run-time data handling, e.g. transmission of calibration programs/parameters, equipment test/status and histogram accumulation. The data transmission system is designed to be used in a loop configuration equipped with transceivers for twisted pair cables (RS-422). As an economical system, it is running as an ancillary serial loop-link between microprocessors, like data acquisition crate controllers and systems with distributed intelligence. The software driver consists of a loop-controller package, which may run in a BAMBI computer language environment and a fully interrupt controlled program for all other secondary stations. A special single-character mode provides a handy link for remote debugging in a pseudo-full-duplex mode. The format is based on the HDLC protocol without sequence numbering. ...

  16. A microprocessor based on a two-dimensional semiconductor

    Wachter, Stefan; Polyushkin, Dmitry K.; Bethge, Ole; Mueller, Thomas

    2017-04-01

    The advent of microcomputers in the 1970s has dramatically changed our society. Since then, microprocessors have been made almost exclusively from silicon, but the ever-increasing demand for higher integration density and speed, lower power consumption and better integrability with everyday goods has prompted the search for alternatives. Germanium and III-V compound semiconductors are being considered promising candidates for future high-performance processor generations and chips based on thin-film plastic technology or carbon nanotubes could allow for embedding electronic intelligence into arbitrary objects for the Internet-of-Things. Here, we present a 1-bit implementation of a microprocessor using a two-dimensional semiconductor--molybdenum disulfide. The device can execute user-defined programs stored in an external memory, perform logical operations and communicate with its periphery. Our 1-bit design is readily scalable to multi-bit data. The device consists of 115 transistors and constitutes the most complex circuitry so far made from a two-dimensional material.

  17. Microprocessor based data acquisition system for Moessbauer spectrometer

    Patwardhan, P.K.; Indurkar, V.S.

    1981-01-01

    A data acquisition system, for Moessbauer spectrometer and other probability distribution spectrum is described. This utilizes the advantages of incorporating a microcomputer for providing a flexible analytical capability and speed of hard wired MCS unit updating channel contents in DMA. Holbourn, Player and Woodhams have recently described a microprocessor controlled Moessbauer spectrometer where microprocessor performs the task of updating channel contents, requiring about 60 micro seconds in interrupt mode. This imposes restrictions on increasing the channel number and on increasing the velocity scan frequency in order to cover higher velocity ranges. The system described in this article performs data acquisition in faster direct memory access. It is a two module system, (1) MCS module (2) Microcomputer module, arranged around a common address, data and control buses. The microcomputer module has an access to the system data during flyback periods and can be programmed for the task of monitor on progess of experiment and as a manipulator of various control operations needed during experiment. The system firmware includes: (1) MONITOR (2) BLOCK-TRANSFER (3) DATA-SMOOTHING (4) DECIMAL-CONVERTER (5) MATH. The scope of this firmware is briefly described. (author)

  18. Microprocessor controlled pulse charge and testing of batteries

    Kerezov, A.; Gishin, S.; Ivanov, Ratcho; Savov, S.

    2002-01-01

    The principle of the developed new method for pulse charge of batteries with microprocessor control of the electrochemical processes is the use of current pulses with microprocessor control of the period and the amplitude according to the dynamically changing state of the electrochemical system. In order to realize the method described above a programmable current source was developed. It is connected with a Personal Computer via RS232 standard serial interface in order to control the electrochemical processes. The parameters to be set, the graphical presentation of the pulse current and tension, the used quantity of electricity and electrical energy for every pulse and for the process as a hole are shown on the PC display. In order to test dry-charged and wet-charged batteries a specialized current generator was developed. It is connected also with a Personal Computer via R5232 standard serial interface in order to con-trol the testing of the starting capability of the batteries according to the requirements of the Bulgarian State Standard Ell 60095-1. (Author)

  19. The use of distributed microprocessors for control devices

    Lejon, J.C.

    1978-01-01

    The use of distributed individual microprocessors provided the basis for the development of the μZ system, which is a modular numerical control device which in its main part contains no elements whatever with multiple functions. With this system, total availability of control is achieved and the failure of any individual element causes loss of automatic control only over one actuator or over a small group of interdependent actuators. The human operator, who cannot be omitted even with an inherently safe control system, can operate the single faulty channel manually. The microprocessors have a free-format with which all possible algorithms within the limits of the memory size of the various cards can be performed. This program can be loaded either in random access memory (RAM) or in read-only memory (ROM). The configuration is made either by assembling software modules in a hard-copy dialogue without any knowledge of data processing being necessary, or from a program written in Fortran. If the user does not have a configurator he can use read-only memories supplied by the manufacter either in the standard form or in a requested design. The parameters are loaded by means of a portable microconsole whose keyboard and displays can be used for a hard-copy dialogue with the regulating cards. Manual control and indications can be carried out from three completely independent configurations which can be used separately or in parallel: individual station, multiple-function station or cathode colour console. (author)

  20. Integration in a nuclear physics experiment of a visualization unit managed by a microprocessor

    Lefebvre, M.

    1976-01-01

    A microprocessor (Intel 8080) is introduced in the equipment controlling the (e,e'p) experiment that will take place at the linear accelerator operating in the premises of CEA (Orme des Merisiers, Gif-sur-Yvette, France). The purpose of the microprocessor is to handle the visualization tasks that are necessary to have a continuous control of the experiment. By doing so more time and more memory will be left for data processing by the calculator unit. In a forward version of the system, the controlling of the level of helium in the target might also be in charge of the microprocessor. This work is divided into 7 main parts: 1) a presentation of the linear accelerator and its experimental facilities, 2) the Intel 8080 micro-processor and its programming, 3) the implementation of the micro-processor in the electronic system, 4) the management of the memory, 5) data acquisition, 6) the keyboard, and 7) the visualization unit [fr

  1. 40 CFR 721.2088 - Carboxylic acids, (C6-C9) branched and linear.

    2010-07-01

    ... linear. 721.2088 Section 721.2088 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Specific Chemical Substances § 721.2088 Carboxylic acids, (C6-C9) branched and linear. (a) Chemical... as carboxylic acids, (C6-C9) branched and linear (PMNs P-93-313, 314, 315, and 316) are subject to...

  2. Positronium formation in CS2 and C6F6 mixtures with triethylamine or tetrahydrofuran

    Zhicheng Zhang; Ito, Yasuo; Tabata, Yoneho

    1990-01-01

    Positronium (Ps) yields were measured for CS 2 /THF, CS 2 /TEA, C 6 F 6 THF and C 6 F 6 /TEA mixtures. Addition of C 6 F 6 or CS 2 into TEA or THF showed a similar influence which induces a decrease of Ps yield. This is ascribed to the non-dissociative electron scavenging by both CS 2 and C 6 F 6 . On the other hand, the effect of addition of TEA and THF has been found to be different for C 6 F 6 and CS 2 , i.e. both TEA and THF did not change Ps yield in CS 2 substantially, while they caused a sharp decrease of Ps yield in C 6 F 6 . The latter sharp decreases was ascribed to quenching of excited state of C 6 F 6 . This interpretation is supported by pulse radiolysis emission measurements for the same system, in which it was found that TEA quenches the excited state of C 6 F 6 efficiently. (author)

  3. 26 CFR 1.381(c)(6)-1 - Depreciation method.

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Depreciation method. 1.381(c)(6)-1 Section 1.381... (CONTINUED) INCOME TAXES Insolvency Reorganizations § 1.381(c)(6)-1 Depreciation method. (a) Carryover... corporation which computes its allowance for the depreciation of the property under section 167(b)(2), (3), or...

  4. Inhibitory effect of 12C6+ ion and X-ray on angiogenesis in HMEC-1

    Liu Yuanyuan; Zhang Hong; Liu Yang; Wu Zhenhua; Sun Chao; Li Hongyan

    2013-01-01

    The study aims to explore the effect of 12 C 6+ ion and X-ray on proliferation, migration, tube formation and MMPS of human microvascular endothelial cells (HMEC-1). Transwell migration experiment showed that the radiation could inhibit the migration of HMEC-1 in sub-lethal dose 24 h after irradiation. Furthermore, the inhibition ability of 12 C 6+ ion was stronger than that of X-ray. Matrigel experiment indicated that 12 C 6+ ion suppressed the tube formation of HMEC-1 spontaneously. However, the inhibitory effect of X-ray had no significance. Meanwhile, Gelatin Zymography showed the expression of MMP-2 was inhibited obviously by 12 C 6+ ion, while X-ray had little effect on the expression of MMP-2. In conclusion, 12 C 6+ ion is superior to X-ray in radiotherapy of tumor. (authors)

  5. Interrogating the vibrational relaxation of highly excited polyatomics with time-resolved diode laser spectroscopy: C6H6, C6D6, and C6F6+CO2

    Sedlacek, A.J.; Weston, R.E. Jr.; Flynn, G.W.

    1991-01-01

    The vibrational relaxation of highly excited ground state benzene, benzene d 6 , and hexafluorobenzene by CO 2 has been investigated with high resolution diode laser spectroscopy. The vibrationally hot polyatomics are formed by single photon 248 nm excitation to the S 1 state followed by rapid radiationless transitions. It has been found that in all cases less than 1% of the energy initially present in the polyatomics is deposited into the high frequency mode of CO 2 (ν 3 ). An investigation of the CO 2 (00 0 1) nascent rotational distribution under single collision conditions reveals that very little rotational excitation accompanies vibrational energy transfer to the ν 3 mode. The CO 2 (ν 3 ) rotational states can be described by temperatures, T rot , as follows: C 6 H 6 , T rot =360±30 K; C 6 D 6 , T rot =350±35 K and C 6 F 6 , T rot =340±23 K. An estimate of left-angle ΔE right-angle ν3 , the mean energy transferred to the CO 2 ν 3 mode per collision, suggests that as the availability of low frequency modes in the excited molecule increases, less energy is deposited into the high frequency mode of CO 2 . Finally, evidence is presented suggesting that even at moderate laser fluences, the two-photon ionization of benzene can lead to substantial CO 2 ν 3 excitation via electron+CO 2 inelastic collisions

  6. PLC-dependent intracellular Ca2+ release was associated with C6-ceramide-induced inhibition of Na+ current in rat granule cells.

    Liu, Zheng; Fei, Xiao-Wei; Fang, Yan-Jia; Shi, Wen-Jie; Zhang, Yu-Qiu; Mei, Yan-Ai

    2008-09-01

    In this report, the effects of C(6)-ceramide on the voltage-gated inward Na(+) currents (I(Na)), two types of main K(+) current [outward rectifier delayed K(+) current (I(K)) and outward transient K(+) current (I(A))], and cell death in cultured rat cerebellar granule cells were investigated. At concentrations of 0.01-100 microM, ceramide produced a dose-dependent and reversible inhibition of I(Na) without alteration of the steady-state activation and inactivation properties. Treatment with C(2)-ceramide caused a similar inhibitory effect on I(Na). However, dihydro-C(6)-ceramide failed to modulate I(Na). The effect of C(6)-ceramide on I(Na) was abolished by intracellular infusion of the Ca(2+)-chelating agent, 1,2-bis (2-aminophenoxy) ethane-N, N, N9, N9-tetraacetic acid, but was mimicked by application of caffeine. Blocking the release of Ca(2+) from the sarcoplasmic reticulum with ryanodine receptor blocker induced a gradual increase in I(Na) amplitude and eliminated the effect of ceramide on I(Na). In contrast, the blocker of the inositol 1,4,5-trisphosphate-sensitive Ca(2+) receptor did not affect the action of C(6)-ceramide. Intracellular application of GTPgammaS also induced a gradual decrease in I(Na) amplitude, while GDPbetaS eliminated the effect of C(6)-ceramide on I(Na). Furthermore, the C(6)-ceramide effect on I(Na) was abolished after application of the phospholipase C (PLC) blockers and was greatly reduced by the calmodulin inhibitors. Fluorescence staining showed that C(6)-ceramide decreased cell viability and blocking I(Na) by tetrodotoxin did not mimic the effect of C(6)-ceramide, and inhibiting intracellular Ca(2+) release by dantrolene could not decrease the C(6)-ceramide-induced cell death. We therefore suggest that increased PLC-dependent Ca(2+) release through the ryanodine-sensitive Ca(2+) receptor may be responsible for the C(6)-ceramide-induced inhibition of I(Na), which does not seem to be associated with C(6)-ceramide-induced granule

  7. New metal-organic frameworks of [M(C6H5O7)(C6H6O7)(C6H7O7)(H2O)] . H2O (M=La, Ce) and [Ce2(C2O4)(C6H6O7)2] . 4H2O

    Weng Shengfeng; Wang, Yun-Hsin; Lee, Chi-Shen

    2012-01-01

    Two novel materials, [M(C 6 H 5 O 7 )(C 6 H 6 O 7 )(C 6 H 7 O 7 )(H 2 O)] . H 2 O (M=La(1a), Ce(1b)) and [Ce 2 (C 2 O 4 )(C 6 H 6 O 7 ) 2 ] . 4H 2 O (2), with a metal-organic framework (MOF) were prepared with hydrothermal reactions and characterized with photoluminescence, magnetic susceptibility, thermogravimetric analysis and X-ray powder diffraction in situ. The crystal structures were determined by single-crystal X-ray diffraction. Compound 1 crystallized in triclinic space group P1-bar (No. 2); compound 2 crystallized in monoclinic space group P2 1 /c (No. 14). The structure of 1 is built from a 1D MOF, composed of deprotonated citric ligands of three kinds. Compound 2 contains a 2D MOF structure consisting of citrate and oxalate ligands; the oxalate ligand arose from the decomposition in situ of citric acid in the presence of Cu II ions. Photoluminescence spectra of compounds 1b and 2 revealed transitions between the 5d 1 excited state and two levels of the 4f 1 ground state ( 2 F 5/2 and 2 F 7/2 ). Compounds 1b and 2 containing Ce III ion exhibit a paramagnetic property with weak antiferromagnetic interactions between the two adjacent magnetic centers. - Graphical Abstract: [M(C 6 H 5 O 7 )(C 6 H 6 O 7 )(C 6 H 7 O 7 )(H 2 O)] . H 2 O (M=La(1a), Ce(1b)) and [Ce 2 (C 2 O 4 )(C 6 H 6 O 7 ) 2 ] . 4H 2 O (2)—with 1D and 2D structures were synthesized and characterized. Highlights: ► Two MOF – [M(C 6 H 5 O 7 )(C 6 H 6 O 7 )(C 6 H 7 O 7 )(H 2 O)] . H 2 O (M=La(1a), Ce(1b)) and [Ce 2 (C 2 O 4 )(C 6 H 6 O 7 ) 2 ] . 4H 2 O (2) – with 1D and 2D structures. ► The adjacent chains of the 1D framework were correlated with each other through an oxalate ligand to form a 2D layer structure. ► The source of the oxalate ligand was the decomposition in situ of citric acid oxidized in the presence of Cu II ions.

  8. Microprocessor-based integrated LMFBR core surveillance. Pt. 2

    Elies, V.

    1985-12-01

    This report is the result of the KfK part of a joint study of KfK and INTERATOM. The aim of this study is to explore the advantages of microprocessors and microelectronics for a more sophisticated core surveillance, which is based on the integration of separate surveillance techniques. After a description of the experimental results gained with the different surveillance techniques so far, it is shown which kinds of correlation can be done using the evaluation results obtained from the single surveillance systems. The main part of this report contains the systems analysis of a microcomputer-based system integrating different surveillance methods. After an analysis of the hardware requirements a hardware structure for the integrated system is proposed. The software structure is then described for the subsystem performing the different surveillance algorithms as well as for the system which does the correlation thus deriving additional information from the single results. (orig.) [de

  9. Microprocessor tester for the treat upgrade reactor trip system

    Lenkszus, F.R.; Bucher, R.G.

    1984-01-01

    The upgrading of the Transient Reactor Test (TREAT) Facility at ANL-Idaho has been designed to provide additional experimental capabilities for the study of core disruptive accident (CDA) phenomena. In addition, a programmable Automated Reactor Control System (ARCS) will permit high-power transients up to 11,000 MW having a controlled reactor period of from 15 to 0.1 sec. These modifications to the core neutronics will improve simulation of LMFBR accident conditions. Finally, a sophisticated, multiply-redundant safety system, the Reactor Trip System (RTS), will provide safe operation for both steady state and transient production operating modes. To insure that this complex safety system is functioning properly, a Dedicated Microprocessor Tester (DMT) has been implemented to perform a thorough checkout of the RTS prior to all TREAT operations

  10. Supply system with microprocessor control for electron gun

    Duplin, N.I.; Sergeev, N.N.

    1988-01-01

    Precision supply system for electron gun used in Auger-spectrometer is described. The supply system consists of control and high-voltage parts, made as separate units. Supply high-voltage unit includes system supply module, filament module to supply electron gun cathode and 6 high-volt modules to supply accelerating, modulating and three focusing electrodes of the gun. High-voltage modules have the following characteristics: U-(100-1000)V output voltage, 5x10 -5 U stability, 10 -5 xU pulsation amplitude, J-(0-5)A filament current change range at 10 -4 xJ stability. Control unit including microprocessor, timer and storage devices forms control voltage for all modules and regulates voltage and current of filament at electrodes

  11. A low cost, microprocessor-based battery charge controller

    Pulfrey, D L; Hacker, J [Pulfrey Solar Inc., Vancouver, BC (Canada)

    1990-01-01

    This report describes the design, construction, testing, and evaluation of a microprocessor-based battery charge controller that uses charge integration as the method of battery state-of-charge estimation. The controller is intended for use in medium-size (100-1000W) photovoltaic systems that employ 12V lead-acid batteries for charge storage. The controller regulates the charge flow to the battery and operates in three, automatically-determined modes, namely: charge, equalize, and float. The prototype controller is modular in nature and can handle charge/discharge currents of magnitude up to 80A, depending on the number of circuit boards employed. Evaluation tests and field trials have shown the controller to be very accurate and reliable. Based on the cost of the prototype, it appears that an original equipment manufacturer's selling price of $400 for a 40A (500W) unit may be realistic. 18 figs., 2 tabs.

  12. CFD-simulation of radiator for air cooling of microprocessors in a limitided space

    Trofimov V. E.

    2016-12-01

    Full Text Available One of the final stages of microprocessors development is heat test. This procedure is performed on a special stand, the main element of which is the switching PCB with one or more mounted microprocessor sockets, chipsets, interfaces, jumpers and other components which provide various modes of microprocessor operation. The temperature of microprocessor housing is typically changed using thermoelectric module. The cold surface of the module with controlled temperature is in direct thermal contact with the microprocessor housing designed for cooler installation. On the hot surface of the module a radiator is mounted. The radiator dissipates the cumulative heat flow from both the microprocessor and the module. High density PCB layout, the requirement of free access to the jumpers and interfaces, and the presence of numerous sensors limit the space for radiator mounting and require the use of an extremely compact radiator, especially in air cooling conditions. One of the possible solutions for this problem may reduce the area of the radiator heat-transfer surfaces due to a sharp growth of the heat transfer coefficient without increasing the air flow rate. To ensure a sharp growth of heat transfer coefficient on the heat-transfer surface one should make in the surface one or more dead-end cavities into which the impact air jets would flow. CFD simulation of this type of radiator has been conducted. The heat-aerodynamic characteristics and design recommendations for removing heat from microprocessors in a limited space have been determined.

  13. Analytical system for stable carbon isotope measurements of low molecular weight (C2-C6 hydrocarbons

    T. Röckmann

    2011-06-01

    Full Text Available We present setup, testing and initial results from a new automated system for stable carbon isotope ratio measurements on C2 to C6 atmospheric hydrocarbons. The inlet system allows analysis of trace gases from air samples ranging from a few liters for urban samples and samples with high mixing ratios, to many tens of liters for samples from remote unpolluted regions with very low mixing ratios. The centerpiece of the sample preparation is the separation trap, which is used to separate CO2 and methane from the compounds of interest. The main features of the system are (i the capability to sample up to 300 l of air, (ii long term (since May 2009 operational δ13C accuracy levels in the range 0.3–0.8 ‰ (1-σ, and (iii detection limits of order 1.5–2.5 ngC (collected amount of substance for all reported compounds. The first application of this system was the analysis of 21 ambient air samples taken during 48 h in August 2009 in Utrecht, the Netherlands. Results obtained are generally in good agreement with those from similar urban ambient air studies. Short sample intervals allowed by the design of the instrument help to illustrate the complex diurnal behavior of hydrocarbons in an urban environment, where diverse sources, dynamical processes, and chemical reactions are present.

  14. Development of a Wiimote-based Gesture Recognizer in a Microprocessor Laboratory Course

    Alberto Lorente Leal

    2011-03-01

    Full Text Available This gesture recognizer, developed by students in a third-year microprocessor-based laboratory course, takes Wii remote (Wiimote as an input device to estimate the movements of the user and to compare the detected trajectory with the previously learnt movements, in order to carry out the associated actions. Such a cheap state-of-the-art wireless user interface is very attractive for the students and can be used in many interactive applications, from robotics to virtual reality and multimedia presentations. By combining commercially-available hardware, pattern-matching techniques and programming skills, we are able to foster students' interest on developing innovative potentially-marketable systems. This freeware project, implemented as a configurable publicly-available library, can be adapted to the needs of any course or student. In our laboratory this open-source DLL is used for remotely controlling a robot (based on an open-hardware Arduino platform, using a PC and the Wiimote, although the DLL can be integrated in any C, C++, Java or C# project. A GUI application (based on a Model-View-Presenter paradigm is also provided and can be used as a template for new applications or just for debugging purposes. Although the developed application only uses data from the accelerometers, data from the infrared camera and buttons of the Wiimote is also available.

  15. Solubility of DCH18C6 and n-octanol in nitric acid system

    He Qiange; Wang Jianchen; Chen Jing

    2011-01-01

    Equilibrium solubility of DCH18C6 and n-octanol in aqueous solution were determined by GC. And effects of temperature, concentration of Sr 2+ or HNO 3 were studied. The results indicate that solubility of DCH18C6 is substantial and make the crown ether continually drain from organic phase which could be 3% at most. As diluent, n-octanol could dissolve in water with certain quantity. So n-octanol, and then kerosene should be used to extract DCH18C6 and n-octanol from aqueous phase. Or toluene is taken to recover DCH18C6 and n-octanol at the same time. Above extractants could recover more than 99% of solute from aqueous solution in the volume ratio 1:1. (author)

  16. Quantitative twoplex glycan analysis using 12C6 and 13C6 stable isotope 2-aminobenzoic acid labelling and capillary electrophoresis mass spectrometry.

    Váradi, Csaba; Mittermayr, Stefan; Millán-Martín, Silvia; Bones, Jonathan

    2016-12-01

    Capillary electrophoresis (CE) offers excellent efficiency and orthogonality to liquid chromatographic (LC) separations for oligosaccharide structural analysis. Combination of CE with high resolution mass spectrometry (MS) for glycan analysis remains a challenging task due to the MS incompatibility of background electrolyte buffers and additives commonly used in offline CE separations. Here, a novel method is presented for the analysis of 2-aminobenzoic acid (2-AA) labelled glycans by capillary electrophoresis coupled to mass spectrometry (CE-MS). To ensure maximum resolution and excellent precision without the requirement for excessive analysis times, CE separation conditions including the concentration and pH of the background electrolyte, the effect of applied pressure on the capillary inlet and the capillary length were evaluated. Using readily available 12/13 C 6 stable isotopologues of 2-AA, the developed method can be applied for quantitative glycan profiling in a twoplex manner based on the generation of extracted ion electropherograms (EIE) for 12 C 6 'light' and 13 C 6 'heavy' 2-AA labelled glycan isotope clusters. The twoplex quantitative CE-MS glycan analysis platform is ideally suited for comparability assessment of biopharmaceuticals, such as monoclonal antibodies, for differential glycomic analysis of clinical material for potential biomarker discovery or for quantitative microheterogeneity analysis of different glycosylation sites within a glycoprotein. Additionally, due to the low injection volume requirements of CE, subsequent LC-MS analysis of the same sample can be performed facilitating the use of orthogonal separation techniques for structural elucidation or verification of quantitative performance.

  17. Sensitivity of C6 Glioma Cells Carrying the Human Poliovirus Receptor to Oncolytic Polioviruses.

    Sosnovtseva, A O; Lipatova, A V; Grinenko, N F; Baklaushev, V P; Chumakov, P M; Chekhonin, V P

    2016-10-01

    A humanized line of rat C6 glioma cells expressing human poliovirus receptor was obtained and tested for the sensitivity to oncolytic effects of vaccine strains of type 1, 2, and 3 polioviruses. Presentation of the poliovirus receptor on the surface of C6 glioma cells was shown to be a necessary condition for the interaction of cells with polioviruses, but insufficient for complete poliovirus oncolysis.

  18. Ion irradiation-induced precipitation of Cr23C6 at dislocation loops in austenitic steel

    Jin, Shuoxue; Guo, Liping; Luo, Fengfeng; Yao, Zhongwen; Ma, Shuli; Tang, Rui

    2013-01-01

    The irradiation-induced precipitates in argon ion-irradiated austenitic stainless steel at 550 °C were examined via transmission electron microscopy. The selected-area electron diffraction patterns of precipitates indicated unambiguously that the precipitates were Cr 23 C 6 carbides. It was observed directly for the first time that irradiation-induced Cr 23 C 6 precipitates formed at dislocation loops in austenitic stainless steel, and coarsened with increasing irradiation dose.

  19. Coprecipitation of M23C6 and MC type carbide under the influence of irradiation

    Kesternich, W.; Nandedkar, R.V.

    1991-01-01

    After high-temperature neutron irradiation of 1.4970 type steel, M 23 C 6 precipitation was observed in the matrix. This precipitate phase was found only at grain boundaries after thermal treatments. A unique feature of this irradiation-modified phase formation was that the M 23 C 6 precipitates nucleated at the surfaces of pre-existing MC type carbides and grew in a very unusual way by forming facetted enclosures around the primary precipitates. (orig.)

  20. The novel cytochrome c6 of chloroplasts: a case of evolutionary bricolage?

    Howe, Christopher J; Schlarb-Ridley, Beatrix G; Wastl, Juergen; Purton, Saul; Bendall, Derek S

    2006-01-01

    Cytochrome c6 has long been known as a redox carrier of the thylakoid lumen of cyanobacteria and some eukaryotic algae that can substitute for plastocyanin in electron transfer. Until recently, it was widely accepted that land plants lack a cytochrome c6. However, a homologue of the protein has now been identified in several plant species together with an additional isoform in the green alga Chlamydomonas reinhardtii. This form of the protein, designated cytochrome c6A, differs from the 'conventional' cytochrome c6 in possessing a conserved insertion of 12 amino acids that includes two absolutely conserved cysteine residues. There are conflicting reports of whether cytochrome c6A can substitute for plastocyanin in photosynthetic electron transfer. The evidence for and against this is reviewed and the likely evolutionary history of cytochrome c6A is discussed. It is suggested that it has been converted from a primary role in electron transfer to one in regulation within the chloroplast, and is an example of evolutionary 'bricolage'.

  1. A procedure for solving the neutron diffusion equation on a parallel micro-processor; modifications to the nodal expansion codes RECNEC and HEXNEC to implement the procedure

    Putney, J.M.

    1983-05-01

    The characteristics of a simple parallel micro-processor (PMP) are reviewed and its software requirements discussed. One of the more immediate applications is the multi-spatial simulation of a nuclear reactor station. This is of particular interest because 3D reactor simulation might then be possible as part of operating procedure for PFR and CDFR. A major part of a multi-spatial reactor simulator is the solution of the neutron diffusion equation. A procedure is described for solving the equation on a PMP, which is applied to the nodal expansion method with modifications to the nodal expansion codes RECNEC and HEXNEC. Estimations of the micro-processor requirements for the simulation of both PFR and CDFR are given. (U.K.)

  2. Fine and hyperfine collisional excitation of C6H by He

    Walker, Kyle M.; Lique, François; Dawes, Richard

    2018-01-01

    Hydrogenated carbon chains have been detected in interstellar and circumstellar media and accurate modelling of their abundances requires collisional excitation rate coefficients with the most abundant species. Among them, the C6H molecule is one of the most abundant towards many lines of sight. Hence, we determined fine and hyperfine-resolved rate coefficients for the excitation of C6H(X2Π) due to collisions with He. We present the first interaction potential energy surface for the C6H-He system, obtained from highly correlated ab initio calculations and characterized by a large anisotropy due to the length of the molecule. We performed dynamical calculations for transitions among the first fine structure levels (up to J = 30.5) of both spin-orbit manifolds of C6H using the close-coupling method, and rate coefficients are determined for temperatures ranging from 5 to 100 K. The largest rate coefficients for even ΔJ transitions conserve parity, while parity-breaking rate coefficients are favoured for odd ΔJ. Spin-orbit changing rate coefficients are several orders of magnitude lower than transitions within a single manifold. State-to-state hyperfine-resolved cross-sections for the first levels (up to J = 13.5) in the Ω = 3/2 spin-orbit manifold are deduced using recoupling techniques. Rate coefficients are obtained and the propensity rule ΔJ = ΔF is seen. These new data will help determine the abundance of C6H in astrophysical environments such as cold dense molecular clouds, star-forming regions and circumstellar envelopes, and will help in the interpretation of the puzzling C6H-/C6H abundance ratios deduced from observations.

  3. Estradiol Receptors Regulate Differential Connexin 43 Expression in F98 and C6 Glioma Cell Lines.

    Zahra Moinfar

    Full Text Available Glioma is the most common malignant primary brain tumour with male preponderance and poor prognosis. Glioma cells express variable amounts of connexin 43 (Cx43 and estrogen receptors (ERs. Both, Cx43 and ERs, play important roles in cell proliferation and migration. Therefore, we investigated the effects of 17-ß estradiol (E2 on Cx43 expression in two glioma cell lines with variable native expression of Cx43.F98 and C6 rat glioma cells were cultured for 24 h in the presence of 10 nM or 100 nM E2, and the E2-antagonist, Fulvestrant. An MTT assay was performed to evaluate cell viability. ERα, ERβ and Cx43 protein expressions were analysed by western blotting and Cx43 mRNA expression was analysed by real-time polymerase chain reaction. To quantify cell migration, an exclusive zone migration assay was used. Functional coupling of cells via gap junctions was examined using whole-cell patch-clamp technique.E2 reduced Cx43 expression in C6 cells, but increased Cx43 expression in F98 cultures. These effects were mediated via ERs. Moreover, E2 promoted C6 cell migration, but it did not affect F98 cell migration. The expression level of ERα was found to be high in C6, but low in F98 cells. ERβ was exclusively expressed in C6 cells. In addition, E2 treatment induced a significant decrease of ERβ in C6 cultures, while it decreased ERα expression in F98 glioma cells.These findings show that E2 differentially modulates Cx43 expression in F98 and C6 glioma cells, likely due to the differential expression of ERs in each of these cell lines. Our findings point to the molecular mechanisms that might contribute to the gender-specific differences in the malignancy of glioma and could have implications for therapeutic strategies against glioma.

  4. C6/36 Aedes albopictus cells have a dysfunctional antiviral RNA interference response.

    Doug E Brackney

    2010-10-01

    Full Text Available Mosquitoes rely on RNA interference (RNAi as their primary defense against viral infections. To this end, the combination of RNAi and invertebrate cell culture systems has become an invaluable tool in studying virus-vector interactions. Nevertheless, a recent study failed to detect an active RNAi response to West Nile virus (WNV infection in C6/36 (Aedes albopictus cells, a mosquito cell line frequently used to study arthropod-borne viruses (arboviruses. Therefore, we sought to determine if WNV actively evades the host's RNAi response or if C6/36 cells have a dysfunctional RNAi pathway. C6/36 and Drosophila melanogaster S2 cells were infected with WNV (Flaviviridae, Sindbis virus (SINV, Togaviridae and La Crosse virus (LACV, Bunyaviridae and total RNA recovered from cell lysates. Small RNA (sRNA libraries were constructed and subjected to high-throughput sequencing. In S2 cells, virus-derived small interfering RNAs (viRNAs from all three viruses were predominantly 21 nt in length, a hallmark of the RNAi pathway. However, in C6/36 cells, viRNAs were primarily 17 nt in length from WNV infected cells and 26-27 nt in length in SINV and LACV infected cells. Furthermore, the origin (positive or negative viral strand and distribution (position along viral genome of S2 cell generated viRNA populations was consistent with previously published studies, but the profile of sRNAs isolated from C6/36 cells was altered. In total, these results suggest that C6/36 cells lack a functional antiviral RNAi response. These findings are analogous to the type-I interferon deficiency described in Vero (African green monkey kidney cells and suggest that C6/36 cells may fail to accurately model mosquito-arbovirus interactions at the molecular level.

  5. Fuzzy Concurrent Object Oriented Expert System for Fault Diagnosis in 8085 Microprocessor Based System Board

    Mr.D. V. Kodavade; Dr. Mrs.S.D.Apte

    2014-01-01

    With the acceptance of artificial intelligence paradigm, a number of successful artificial intelligence systems were created. Fault diagnosis in microprocessor based boards needs lot of empirical knowledge and expertise and is a true artificial intelligence problem. Research on fault diagnosis in microprocessor based system boards using new fuzzy-object oriented approach is presented in this paper. There are many uncertain situations observed during fault diagnosis. These uncertain situations...

  6. Nonconformance in electromechanical output relays of microprocessor-based protection devices under actual operating conditions

    Gurevich, Vladimir

    2006-01-01

    Microprocessor-based protection relays are gradually driving out traditional electromechanical and even electronic protection devices from virtually all fields of power and electrical engineering. In this paper, one of many problems of microprocessor-based relays is discussed: nonconformance of miniature electromechanical output relays under actual operation conditions: switching inductive loads (with tripping CB coils or lockout relay coils) at 220 VDC, and "dry" switching of some control ci...

  7. Enzymatic Hydrolysis of Pretreated Fibre Pressed Oil Palm Frond by using Sacchariseb C6

    Hashim, F. S.; Yussof, H. W.; Zahari, M. A. K. M.; Rahman, R. A.; Illias, R. M.

    2017-06-01

    Enzymatic hydrolysis becomes a prominent technology for conversion of cellulosic biomass to its glucose monomers that requires an action of cellulolytic enzymes in a sequential and synergistic manner. In this study, the effect of agitation speed, glucan loading, enzyme loading, temperature and reaction time on the production of glucose from fibre pressed oil palm frond (FPOPF) during enzymatic hydrolysis was screened by a half factorial design 25-1 using Response Surface Methodology (RSM). The FPOPF sample was first delignified by alkaline pretreatment at 4.42 (w/v) sodium hydroxide for an hour prior to enzymatic hydrolysis using commercial cellulase enzyme, Sacchariseb C6. The effect of enzymatic hydrolysis on the structural of FPOPF has been evaluated by Scanning Electron Microscopy (SEM) analysis. Characterization of raw FPOPF comprised of 4.5 extractives, 40.7 glucan, 26.1 xylan, 26.2 lignin and 1.8 ash, whereas for pretreated FPOPF gave 0.3 extractives, 61.4 glucan, 20.4 xylan, 13.3 lignin and 1.3 ash. From this study, it was found that the best enzymatic hydrolysis condition yielded 33.01 ± 0.73 g/L of glucose when performed at 200 rpm of agitation speed, 60 FPU/mL of enzyme loading, 4 (w/w) of glucan loading, temperature at 55 □ and 72 hours of reaction time. The model obtained was significant with p-value enzymatic hydrolysis from pretreated FPOPF produce high amount of glucose that enhances it potential for industrial application. This glucose can be further used to produce high-value products.

  8. MicroShell Minimalist Shell for Xilinx Microprocessors

    Werne, Thomas A.

    2011-01-01

    MicroShell is a lightweight shell environment for engineers and software developers working with embedded microprocessors in Xilinx FPGAs. (MicroShell has also been successfully ported to run on ARM Cortex-M1 microprocessors in Actel ProASIC3 FPGAs, but without project-integration support.) Micro Shell decreases the time spent performing initial tests of field-programmable gate array (FPGA) designs, simplifies running customizable one-time-only experiments, and provides a familiar-feeling command-line interface. The program comes with a collection of useful functions and enables the designer to add an unlimited number of custom commands, which are callable from the command-line. The commands are parameterizable (using the C-based command-line parameter idiom), so the designer can use one function to exercise hardware with different values. Also, since many hardware peripherals instantiated in FPGAs have reasonably simple register-mapped I/O interfaces, the engineer can edit and view hardware parameter settings at any time without stopping the processor. MicroShell comes with a set of support scripts that interface seamlessly with Xilinx's EDK tool. Adding an instance of MicroShell to a project is as simple as marking a check box in a library configuration dialog box and specifying a software project directory. The support scripts then examine the hardware design, build design-specific functions, conditionally include processor-specific functions, and complete the compilation process. For code-size constrained designs, most of the stock functionality can be excluded from the compiled library. When all of the configurable options are removed from the binary, MicroShell has an unoptimized memory footprint of about 4.8 kB and a size-optimized footprint of about 2.3 kB. Since MicroShell allows unfettered access to all processor-accessible memory locations, it is possible to perform live patching on a running system. This can be useful, for instance, if a bug is

  9. HeLa DNA damage response induced by 12C6+ ions

    Chen Jidong; Li Ning; Zhang Hong; Wu Zhenhua

    2009-01-01

    The aim of this study is to explore the DNA damage response of HeLa irradiated by 12 C 6+ beam and the mechanism of the p53 activation change in this response.In our present study, double strands break(DSB)of HeLa cells irradiated with 12 C 6+ beam were detected through neutral single cell gel electrophoresis, and AO/EB staining was used to detect the apoptosis of irradiated HeLa in 24h irradiation. Moreover, HeLa was pre-treated with caffeine (ATM and ATR inhibiting) or wormannin with certain concentrations (20 μmol/L, ATM and DNA-PK inhibiting) and irradiated with 1Gy of 12 C 6+ beam,and the expression of p53 was detected with Western blot analysis. The results show that DSB of HeLa caused by 12 C 6+ beam increases with absorbed doses and decreases with the time after irradiation. The apoptosis percentage of irradiated HeLa increases with absorbed doses. It has been found that the p53 expression increases after irradiation, but has not significant increment with caffeine or wortmannin pre-treatment in cells.It can be deduced that the p53 activation is ATM-dependent, but not ATR and DNA-PK-dependent in HeLa DNA damage response induced by 12 C 6+ beam. (authors)

  10. The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals.

    Wang, Yahua; Ying, Xue; Xu, Haolun; Yan, Helu; Li, Xia; Tang, Hui

    2017-01-01

    Glioblastoma is a kind of malignant gliomas that is almost impossible to cure due to the poor drug transportation across the blood-brain barrier and the existence of glioma stem cells. We prepared a new kind of targeted liposomes in order to improve the drug delivery system onto the glioma cells and induce the apoptosis of glioma stem cells afterward. In this experiment, curcumin was chosen to kill gliomas, while quinacrine was used to induce apoptosis of the glioma stem cells. Also, p -aminophenyl-α-D-mannopyranoside could facilitate the transport of liposomes across the blood-brain barrier and finally target the brain glioma cells. The cell experiments in vitro indicated that the targeted liposomes could significantly improve the anti-tumor effects of the drugs, while enhancing the uptake effects, apoptosis effects, and endocytic effects of C6 glioma cells and C6 glioma stem cells. Given the animal experiments in vivo, we discovered that the targeted liposomes could obviously increase the survival period of brain glioma-bearing mice and inhibit the growth of gliomas. In summary, curcumin and quinacrine liposomes modified with p -aminophenyl-α-D-mannopyranoside is a potential preparation to treat brain glioma cells and brain glioma stem cells.

  11. New type of M23C6 carbide precipitation in an austenitic stainless steel containing niobium

    Terao, Nobuzo; Sasmal, B.

    1981-01-01

    An electron microscopic study has been made of precipitation in an austenitic stainless steel, 16Cr-16Ni-0.8Nb-1.8Mo-0.06C. Attention has been focused on structural changes which take place during long ageing treatments, extended up to 14.4 Ms (4000 h). In addition to the wellknown chromium rich M 23 C 6 carbides, which appear, together with NbC, from the beginning of the precipitation treatment at 1073 K, a new plate-like morphology of M 23 C 6 carbide precipitation was observed after long ageing treatments. These M 23 C 6 carbide plates were formed on (110) planes in regions near pre-existing undissolved NbC particles and their edges were bounded by (111) planes of the fcc alloy matrix. It is suggested that this unexpected process might be favoured by the stresses produced around the undissolved NbC particles. (author)

  12. Structural and magnetic properties of Co films on highly textured and randomly oriented C_6_0 layers

    Kim, Dong-Ok; Choi, Jun Woo; Lee, Dong Ryeol

    2016-01-01

    The structural and magnetic properties of Co/C_6_0/pentacene and Co/C_6_0 thin film structures were investigated. Atomic force microscopy and x-ray reflectivity analysis show that the presence or absence of a pentacene buffer layer leads to a highly textured or randomly oriented C_6_0 layer, respectively. A Co film deposited on a randomly oriented C_6_0 layer penetrates into the C_6_0 layer when it is deposited at a slow deposition rate. The Co penetration can be minimized, regardless of the Co deposition rate, by growth on a highly textured and nanostructured C_6_0/pentacene layer. Vibrating sample magnetometry measurements show that the saturation magnetization of Co/C_6_0/pentacene is significantly reduced compared to that of Co/C_6_0. On the other hand, the Co penetration does not seem to have an effect on the magnetic properties, suggesting that the structural properties of the Co and C_6_0 layer, rather than the Co penetration into the organic C_6_0 layer, are critical to the magnetic properties of the Co/C_6_0. - Highlights: • Structural and magnetic properties of metal(Co)-organic(C_6_0) interface is studied. • Highly textured C_6_0 layer was grown on a pentacene buffer layer (C_6_0/pentacene). • Co penetration into the C_6_0 is significantly suppressed in Co/C_6_0/pentacene. • The Co magnetization in Co/C_6_0/pentacene is reduced than that in Co/C_6_0.

  13. The Prevalence of Medial Epicondylitis Among Patients With C6 and C7 Radiculopathy

    Lee, Aaron Taylor; Lee-Robinson, Ayse L.

    2010-01-01

    Background: Medial epicondylitis, or golfer’s/pitcher’s elbow, develops as a result of medial stress overload on the flexor muscles at the elbow and presents as pain at the medial epicondyle. Cervical radiculopathy has been associated with lateral epicondylitis, but few associations between the cervical spine and medial epicondylitis have been made. Researchers propose that there is an association, suggesting that the weakness and imbalance in the elbow flexor and extensor muscles from C6 and C7 radiculopathy allow for easy onset of medial epicondylitis. Hypothesis: Medial epicondylitis will present in over half the patients diagnosed with C6 and C7 radiculopathy. Methodology: A total of 102 patients initially presenting with upper extremity or neck symptoms were diagnosed with cervical radiculopathy. They were then examined for medial epicondylitis. Data were collected by referring to patient charts from February 2008 until June 2009. Results: Fifty-five patients were diagnosed with medial epicondylitis. Of these, 44 had C6 and C7 radiculopathy whereas 11 presented with just C6 radiculopathy. Conclusion: Medial epicondylitis presented with cervical radiculopathy in slightly more than half the patients. Weakening of the flexor carpi radialis and pronator teres and imbalance of the flexor and extensor muscles from the C6 and C7 radiculopathy allow for easy onset of medial epicondylitis. Patients with medial epicondylitis should be examined for C6 and C7 radiculopathy to ensure proper treatment. Physicians dealing with golfers, pitchers, or other patients with medial epicondylitis should be aware of the association between these 2 diagnoses to optimize care. PMID:23015956

  14. A microprocessor-based power control data acquisition system

    Greenberg, S.

    1982-10-01

    The project reported deals with one of the aspects of power plant control and management. In order to perform optimal distribution of power and load switching, one has to solve a specific optimization problem. In order to solve this problem one needs to collect current and power expenditure data from a large number of channels and have them processed. This particular procedure is defined as data acquisition and it constitutes the main topic of this project. A microprocessor-based data acquisition system for power management is investigated and developed. The current and power data of about 100 analog channels are sampled and collected in real-time. These data are subsequently processed to calculate the power factor (cos phi) for each channel and the maximum demand. The data is processed by an AMD 9511 Arithmetic Processing Unit and the whole system is controlled by an Intel 8080A CPU. All this information is then transfered to a universal computer through a synchronized communication channel. The optimization computations would be performed by the high level computer. Different ways of performing the search of data over a large number of channels have been investigated. A particular solution to overcome the gain and offset drift of the A/D converter, using software, has been proposed. The 8080A supervises the collection and routing of data in real time, while the 9511 performs calculation, using these data. (Author)

  15. Biosorption of gold from computer microprocessor leachate solutions using chitin.

    Côrtes, Letícia N; Tanabe, Eduardo H; Bertuol, Daniel A; Dotto, Guilherme L

    2015-11-01

    The biosorption of gold from discarded computer microprocessor (DCM) leachate solutions was studied using chitin as a biosorbent. The DCM components were leached with thiourea solutions, and two procedures were tested for recovery of gold from the leachates: (1) biosorption and (2) precipitation followed by biosorption. For each procedure, the biosorption was evaluated considering kinetic, equilibrium, and thermodynamic aspects. The general order model was able to represent the kinetic behavior, and the equilibrium was well represented by the BET model. The maximum biosorption capacities were around 35 mg g(-1) for both procedures. The biosorption of gold on chitin was a spontaneous, favorable, and exothermic process. It was found that precipitation followed by biosorption resulted in the best gold recovery, because other species were removed from the leachate solution in the precipitation step. This method enabled about 80% of the gold to be recovered, using 20 g L(-1) of chitin at 298 K for 4 h. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Microprocessor-controlled wide-range streak camera

    Lewis, Amy E.; Hollabaugh, Craig

    2006-08-01

    Bechtel Nevada/NSTec recently announced deployment of their fifth generation streak camera. This camera incorporates many advanced features beyond those currently available for streak cameras. The arc-resistant driver includes a trigger lockout mechanism, actively monitors input trigger levels, and incorporates a high-voltage fault interrupter for user safety and tube protection. The camera is completely modular and may deflect over a variable full-sweep time of 15 nanoseconds to 500 microseconds. The camera design is compatible with both large- and small-format commercial tubes from several vendors. The embedded microprocessor offers Ethernet connectivity, and XML [extensible markup language]-based configuration management with non-volatile parameter storage using flash-based storage media. The camera's user interface is platform-independent (Microsoft Windows, Unix, Linux, Macintosh OSX) and is accessible using an AJAX [asynchronous Javascript and XML]-equipped modem browser, such as Internet Explorer 6, Firefox, or Safari. User interface operation requires no installation of client software or browser plug-in technology. Automation software can also access the camera configuration and control using HTTP [hypertext transfer protocol]. The software architecture supports multiple-simultaneous clients, multiple cameras, and multiple module access with a standard browser. The entire user interface can be customized.

  17. Microprocessor-controlled, wide-range streak camera

    Amy E. Lewis; Craig Hollabaugh

    2006-01-01

    Bechtel Nevada/NSTec recently announced deployment of their fifth generation streak camera. This camera incorporates many advanced features beyond those currently available for streak cameras. The arc-resistant driver includes a trigger lockout mechanism, actively monitors input trigger levels, and incorporates a high-voltage fault interrupter for user safety and tube protection. The camera is completely modular and may deflect over a variable full-sweep time of 15 nanoseconds to 500 microseconds. The camera design is compatible with both large- and small-format commercial tubes from several vendors. The embedded microprocessor offers Ethernet connectivity, and XML [extensible markup language]-based configuration management with non-volatile parameter storage using flash-based storage media. The camera's user interface is platform-independent (Microsoft Windows, Unix, Linux, Macintosh OSX) and is accessible using an AJAX [asynchronous Javascript and XML]-equipped modem browser, such as Internet Explorer 6, Firefox, or Safari. User interface operation requires no installation of client software or browser plug-in technology. Automation software can also access the camera configuration and control using HTTP [hypertext transfer protocol]. The software architecture supports multiple-simultaneous clients, multiple cameras, and multiple module access with a standard browser. The entire user interface can be customized

  18. EOSCOR: a light weight, microprocessor controlled solar neutron detector

    Koga, R.; Albats, P.; Frye, G.M. Jr.; Schindler, S.M.; Denehy, B.V.; Hopper, V.D.; Mace, O.B.

    1979-01-01

    A light weight high energy neutron detector with vertical detection efficiency of 0.005 at 40 MeV and 1.4 m 2 sensitive area has been developed for long duration super-pressure balloon flight observations of solar neutrons and gamma rays. It consists of two sets of four plastic scintillator hodoscopes separated by a 1 m time-of-flight path to observe n-p, C(n,p), and C(n,d) interactions. The neutron interactions are separated from gamma ray events through TOF measurements. For a large flare, the signal from solar neutrons is expected to be an order of magnitude greater than that of the atmospheric background. The microprocessor controls the data acquisition, accumulation of histograms, and the encoding of data for the telemetry systems. A test flight of the detector was made with a zero-pressure balloon. The expected many-week duration of a super-pressure balloon flight would significantly increase the probability of observing 20-150 MeV neutrons from a medium or large flare. (Auth.)

  19. Microprocessor-controlled, wide-range streak camera

    Amy E. Lewis, Craig Hollabaugh

    2006-09-01

    Bechtel Nevada/NSTec recently announced deployment of their fifth generation streak camera. This camera incorporates many advanced features beyond those currently available for streak cameras. The arc-resistant driver includes a trigger lockout mechanism, actively monitors input trigger levels, and incorporates a high-voltage fault interrupter for user safety and tube protection. The camera is completely modular and may deflect over a variable full-sweep time of 15 nanoseconds to 500 microseconds. The camera design is compatible with both large- and small-format commercial tubes from several vendors. The embedded microprocessor offers Ethernet connectivity, and XML [extensible markup language]-based configuration management with non-volatile parameter storage using flash-based storage media. The camera’s user interface is platform-independent (Microsoft Windows, Unix, Linux, Macintosh OSX) and is accessible using an AJAX [asynchronous Javascript and XML]-equipped modem browser, such as Internet Explorer 6, Firefox, or Safari. User interface operation requires no installation of client software or browser plug-in technology. Automation software can also access the camera configuration and control using HTTP [hypertext transfer protocol]. The software architecture supports multiple-simultaneous clients, multiple cameras, and multiple module access with a standard browser. The entire user interface can be customized.

  20. Model based design introduction: modeling game controllers to microprocessor architectures

    Jungwirth, Patrick; Badawy, Abdel-Hameed

    2017-04-01

    We present an introduction to model based design. Model based design is a visual representation, generally a block diagram, to model and incrementally develop a complex system. Model based design is a commonly used design methodology for digital signal processing, control systems, and embedded systems. Model based design's philosophy is: to solve a problem - a step at a time. The approach can be compared to a series of steps to converge to a solution. A block diagram simulation tool allows a design to be simulated with real world measurement data. For example, if an analog control system is being upgraded to a digital control system, the analog sensor input signals can be recorded. The digital control algorithm can be simulated with the real world sensor data. The output from the simulated digital control system can then be compared to the old analog based control system. Model based design can compared to Agile software develop. The Agile software development goal is to develop working software in incremental steps. Progress is measured in completed and tested code units. Progress is measured in model based design by completed and tested blocks. We present a concept for a video game controller and then use model based design to iterate the design towards a working system. We will also describe a model based design effort to develop an OS Friendly Microprocessor Architecture based on the RISC-V.

  1. Different microprocessor controlled devices for ITU TRIGA Mark II reactor

    Can, B.; Omuz, S.; Uzun, S.; Apan, H.

    1990-01-01

    In this paper the design of a period meter and multichannel thermometer, which are controlled by a microprocessor, in order to be used at ITU TRIGA Mark-II Reactor is presented. The system works as a simple microcomputer, which includes a CPU, a EPROM, a RAM, a CTC, a PIO, a PIA a keyboard and displays, using the assembly language. The period meter can work either with pulse signal or with analog signal depending on demand of the user. The period is calculated by software and its range is -99,9 sec, to +2.1 sec. When the period drops +3 sec, the system gives alarm illuminating a LED. The multichannel thermometer has eight temperature channels. Temperature channels can manually or automatically be selected. The channel selection time can be adjusted. The thermometer gives alarm illuminating a LED, when the temperature rises to 600 C. Temperature data is stored in the RAM and is shown on a display. This system provides us to use four spare thermocouples in the reactor. (orig.)

  2. Elimination of C-6-hydrogen during the formation of ecdysteroids from cholesterol in Locusta migratoria ovaries

    Fujimoto, Y.; Hiramoto, M.; Kakinuma, K.; Ikekawa, N.

    1989-01-01

    Being administered to Locusta migratoria adult females, [6- 3 H, 4- 14 C]cholesterol was incorporated into ecdysone and 2-deoxyecdysone. The ratio of 3 H/ 14 C of the two ecdysteroids isolated from newly laid eggs revealed that C-6-hydrogen of cholesterol was eliminated during the conversion to ecdysteroids in the ovaries of the insects. Thus, a hypothetical mechanism involving migration of the C-6-hydrogen to the C-5 position in the formation of A/B cis junction turned out to be less likely

  3. Observation of charge-exchange spectra on C6+ +H in low-energy collision

    Kobuchi, Takashi; Sato, Kuninori; Goto, Motoshi; Ohyabu, Nobuyoshi; Kawahata, Kazuo; Sudo, Shigeru; Motojima, Osamu

    2003-01-01

    The extreme ultraviolet spectra of C VI have been studied for a Neutral Beam Injection (NBI) plasmas in Large Helical Device (LHD). A strong distortion in the population distribution over the excited levels was observed and we conclude that is caused by charge-exchange recombining (CXR) processes between C 6+ ion and recycling neutral hydrogen. Spatially resolved measurements show that the C 6+ -H CXR processes take place in the plasma peripheral region in LHD. We have taken a CXR part of C VI 1s-4p line using the result of a calculation code. (author)

  4. Bridging Binding Modes of Phosphine-Stabilized Nitrous Oxide to Zn(C6F5)2

    Neu, Rebecca C.; Otten, Edwin; Stephan, Douglas W.

    2009-01-01

    Reaction of [tBu3PN2O(B(C6H4F)3)] with 1, 1.5, or 2 equivalents of Zn(C6F5)2 affords the species [{tBu3PN2OZn(C6F5)2}2], [{tBu3PN2OZn(C6F5)2}2Zn(C6F5)2], and [tBu3PN2O{Zn(C6F5)2}2] displaying unique binding modes of Zn to the phosphine-stabilized N2O fragment.

  5. Combined dehydration/(transfer)-hydrogenation of C6-sugars (D-glucose and D-fructose) to gamma-valerolactone using ruthenium catalysts

    Heeres, Hans; Handana, Ratna; Chunai, Dai; Rasrendra, Carolus Borromeus; Girisuta, Buana; Heeres, Hero Jan

    2009-01-01

    gamma-Valerolactone (GVL) is considered a very interesting green, bio-based platform chemical with high application potential. We here describe research activities on the one-pot catalytic synthesis of GVL from C6-sugar sources (D-glucose, D-fructose, sucrose and cellulose) using an acid catalyst in

  6. [2,4-(13)C]β-hydroxybutyrate metabolism in astrocytes and C6 glioblastoma cells.

    Eloqayli, Haytham; Melø, Torun M; Haukvik, Anne; Sonnewald, Ursula

    2011-08-01

    This study was undertaken to determine if the ketogenic diet could be useful for glioblastoma patients. The hypothesis tested was whether glioblastoma cells can metabolize ketone bodies. Cerebellar astrocytes and C6 glioblastoma cells were incubated in glutamine and serum free medium containing [2,4-(13)C]β-hydroxybutyrate (BHB) with and without glucose. Furthermore, C6 cells were incubated with [1-(13)C]glucose in the presence and absence of BHB. Cell extracts were analyzed by mass spectrometry and media by (1)H magnetic resonance spectroscopy and HPLC. Using [2,4-(13)C]BHB and [1-(13)C]glucose it could be shown that C6 cells, in analogy to astrocytes, had efficient mitochondrial activity, evidenced by (13)C labeling of glutamate, glutamine and aspartate. However, in the presence of glucose, astrocytes were able to produce and release glutamine, whereas this was not accomplished by the C6 cells, suggesting lack of anaplerosis in the latter. We hypothesize that glioblastoma cells kill neurons by not supplying the necessary glutamine, and by releasing glutamate.

  7. Boronophenylalanine uptake in C6 glioma model is dramatically increased by L-DOPA preloading

    Capuani, S. [CNR-INFM SOFT, Department of Physics, Sapienza University of Rome, Piazzale Aldo Moro 2, Rome (Italy); Enrico Fermi Center, Compendio Viminale, Rome (Italy)], E-mail: silvia.capuani@roma1.infn.it; Gili, T. [CNR-INFM SOFT, Department of Physics, Sapienza University of Rome, Piazzale Aldo Moro 2, Rome (Italy); Enrico Fermi Center, Compendio Viminale, Rome (Italy); Bozzali, M. [Neuroimaging Laboratory, Santa Lucia Foundation, Via Ardeatina 306, Rome (Italy); Russo, S. [Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London (United Kingdom); Porcari, P. [CNR-INFM SOFT, Department of Physics, Sapienza University of Rome, Piazzale Aldo Moro 2, Rome (Italy); Cametti, C. [CNR-INFM SOFT, Department of Physics, Sapienza University of Rome, Piazzale Aldo Moro 2, Rome (Italy); Department of Physics, Sapienza University of Rome, Piazzale Aldo Moro 2, Rome (Italy); Muolo, M. [Department of Biological Science, University ' Rome III' , Viale G. Marconi 446, Rome (Italy); D' Amore, E. [Serv. Qual./Sicurezza Sperim. Anim., Istituto Superiore di Sanita, Rome (Italy); Maraviglia, B. [Enrico Fermi Center, Compendio Viminale, Rome (Italy); Neuroimaging Laboratory, Santa Lucia Foundation, Via Ardeatina 306, Rome (Italy); Lazzarino, G. [Laboratory of Biochemistry, Department of Chemical Sciences, University of Catania, Viale A. Doria 6, Catania (Italy); Pastore, F.S. [Department of Neuroscience, Institute of Neurosurgery, University ' Tor Vergata' , Via Montpellier 1, Rome (Italy)

    2009-07-15

    One of the main limitations for BNCT effectiveness is the insufficient intake of {sup 10}B nuclei within tumour cells. This work was aimed at investigating the use of L-DOPA as enhancer for boronophenylalanine (BPA) uptake in the C6 glioma model. The investigation was first performed in vitro, and then extended in vivo to the animal model. BPA accumulation in C6 glioma cells was assessed, using radiowave dielectric spectroscopy (RDS), with and without L-DOPA preloading. C6 glioma cells were also implanted in the brain of 25 rats, randomly assigned to two experimental branches: (1) intra-carotid BPA infusion; (2) intra-carotid BPA infusion after pre-treatment with L-DOPA, administrated 24 h before BPA infusion. All animals were sacrificed, and assessment of BPA concentrations in tumour tissue, normal brain, and blood samples was performed using high performance liquid chromatography (HPLC). L-DOPA preloading induced a massive increase of BPA concentration either in vitro on C6 glioma cells or in vivo in the animal model tumour. Moreover, no significant difference was found in the normal brain and blood samples between the two animal groups. This study suggests the potential use of L-DOPA as enhancer for BPA accumulation in malignant gliomas eligible for BNCT.

  8. Modeling the degradation mechanisms of C6/LiFePO4 batteries

    Li, D.; Danilov, D.L.; Zwikirsch, B.; Fichtner, M.; Yang, Y.; Eichel, R.A.; Notten, P.H.L.

    2018-01-01

    A fundamental electrochemical model is developed, describing the capacity fade of C6/LiFePO4 batteries as a function of calendar time and cycling conditions. At moderate temperatures the capacity losses are mainly attributed to Li immobilization in Solid-Electrolyte-Interface (SEI) layers at the

  9. Catalytic pyrolysis of recalcitrant, insoluble humin byproducts from C6 sugar biorefineries

    Agarwal, Shilpa; van Es, Daan; Heeres, Hero Jan

    Humins are solid by-products formed during the acid-catalysed conversions of C-6 sugars to platform chemicals like hydroxymethylfurfural and levulinic acid. We here report an experimental study on the liquefaction/depolymerisation of humins using catalytic pyrolysis. Synthetic humins (SH) and crude

  10. Mode of action of pectin lyase A of Aspergillus niger on differently C6-substituted oligogalacturonides

    Alebeek, van G.J.W.M.; Christensen, T.M.I.E.; Schols, H.A.; Mikkelsen, J.D.; Voragen, A.G.J.

    2002-01-01

    A thorough investigation of the mode of action of Aspergillus niger (4M-147) pectin lyase A (PLA) on differently C6-substituted oligogalacturonides is described. PLA appeared to be very specific for fully methyl-esterified oligogalacturonides: removal of the methyl-ester or changing the type of

  11. Correlated linear response calculations of the C6 dispersion coefficients of hydrogen halides

    Sauer, S. P. A.; Paidarová, Ivana

    2007-01-01

    Roč. 3, 2-4 (2007), s. 399-421 ISSN 1574-0404 R&D Projects: GA AV ČR IAA401870702 Institutional research plan: CEZ:AV0Z40400503 Keywords : hydrogen halides * C6 dospersion coefficients * van der Waals coefficients * polarizability at imaginary frequences * SOPPA Subject RIV: CF - Physical ; Theoretical Chemistry

  12. Synthesis, characterization and biological activity of C6-Schiff bases derivatives of chitosan.

    Xu, Ruibo; Aotegen, Bayaer; Zhong, Zhimei

    2017-12-01

    C 6 -Schiff bases derivatives of chitosan were synthesized for the first time. C 2 -amino groups and C 3 -hydroxy groups were firstly protected by CuSO 4 ·5H 2 O, and the C 6 -hydroxy was then transformed into aldehyde, which then reacted with anilines through nucleophilic addition to introduce the CN group at C 6 -position in chitosan chain. Finally, C 6 -Schiff bases derivatives of chitosan were got by the deprotection of C 2 -NH 2 with cation exchange resin. The structures and properties of the new synthesized products were characterized by Fourier transform infrared spectroscopy, 13 C NMR, SEM image, and elemental analysis. The antibacterial activities of derivatives were tested in the experiment, and the results showed that the prepared chitosan derivatives had significantly improved antibacterial activity toward Staphylococcus aureus and Escherichia coli. The Cytotoxicity test showed that the prepared chitosan derivatives had low Cytotoxicity, compared with chitosan and C 2 -benzaldehyde Schiff bases of chitosan. This paper allowed a new method for the synthesis of Schiff bases of chitosan, which was enlightening. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Boronophenylalanine uptake in C6 glioma model is dramatically increased by L-DOPA preloading

    Capuani, S.; Gili, T.; Bozzali, M.; Russo, S.; Porcari, P.; Cametti, C.; Muolo, M.; D'Amore, E.; Maraviglia, B.; Lazzarino, G.; Pastore, F.S.

    2009-01-01

    One of the main limitations for BNCT effectiveness is the insufficient intake of 10 B nuclei within tumour cells. This work was aimed at investigating the use of L-DOPA as enhancer for boronophenylalanine (BPA) uptake in the C6 glioma model. The investigation was first performed in vitro, and then extended in vivo to the animal model. BPA accumulation in C6 glioma cells was assessed, using radiowave dielectric spectroscopy (RDS), with and without L-DOPA preloading. C6 glioma cells were also implanted in the brain of 25 rats, randomly assigned to two experimental branches: (1) intra-carotid BPA infusion; (2) intra-carotid BPA infusion after pre-treatment with L-DOPA, administrated 24 h before BPA infusion. All animals were sacrificed, and assessment of BPA concentrations in tumour tissue, normal brain, and blood samples was performed using high performance liquid chromatography (HPLC). L-DOPA preloading induced a massive increase of BPA concentration either in vitro on C6 glioma cells or in vivo in the animal model tumour. Moreover, no significant difference was found in the normal brain and blood samples between the two animal groups. This study suggests the potential use of L-DOPA as enhancer for BPA accumulation in malignant gliomas eligible for BNCT.

  14. 26 CFR 1.1402(c)-6 - Members of certain professions.

    2010-04-01

    ...) INCOME TAX (CONTINUED) INCOME TAXES Tax on Self-Employment Income § 1.1402(c)-6 Members of certain..., chiropractor, naturopath, optometrist, Christian Science practitioner, architect, certified public accountant, accountant registered or licensed as an accountant under State or municipal law, full-time practicing public...

  15. Regulation of Plant Microprocessor Function in Shaping microRNA Landscape

    Jakub Dolata

    2018-06-01

    Full Text Available MicroRNAs are small molecules (∼21 nucleotides long that are key regulators of gene expression. They originate from long stem–loop RNAs as a product of cleavage by a protein complex called Microprocessor. The core components of the plant Microprocessor are the RNase type III enzyme Dicer-Like 1 (DCL1, the zinc finger protein Serrate (SE, and the double-stranded RNA binding protein Hyponastic Leaves 1 (HYL1. Microprocessor assembly and its processing of microRNA precursors have been reported to occur in discrete nuclear bodies called Dicing bodies. The accessibility of and modifications to Microprocessor components affect microRNA levels and may have dramatic consequences in plant development. Currently, numerous lines of evidence indicate that plant Microprocessor activity is tightly regulated. The cellular localization of HYL1 is dependent on a specific KETCH1 importin, and the E3 ubiquitin ligase COP1 indirectly protects HYL1 from degradation in a light-dependent manner. Furthermore, proper localization of HYL1 in Dicing bodies is regulated by MOS2. On the other hand, the Dicing body localization of DCL1 is regulated by NOT2b, which also interacts with SE in the nucleus. Post-translational modifications are substantial factors that contribute to protein functional diversity and provide a fine-tuning system for the regulation of protein activity. The phosphorylation status of HYL1 is crucial for its activity/stability and is a result of the interplay between kinases (MPK3 and SnRK2 and phosphatases (CPL1 and PP4. Additionally, MPK3 and SnRK2 are known to phosphorylate SE. Several other proteins (e.g., TGH, CDF2, SIC, and RCF3 that interact with Microprocessor have been found to influence its RNA-binding and processing activities. In this minireview, recent findings on the various modes of Microprocessor activity regulation are discussed.

  16. Equipment calibration with a microprocessor connected to a time-sharing system

    Fontaine, G.; Guglielmi, L.; Jaeger, J.J.; Szafran, S.

    1981-01-01

    In H.E.P., it is common practice to test and calibrate equipment at different stages (design, construction checks, setting up and running periods) with a dedicated mini or micro-computer (such as CERN CAVIAR). An alternative solution has been developed in which such tasks are split between a microprocessor (Motorola 6800), and a host computer; this allows an easy and cheap multiplication of independant testing set-ups. The local processor is limited to CAMAC data acquisition, histogramming and simple processing, but its computing power is enhanced by a connection to a host time-sharing system via a MUMM multiplexor described in a separate paper. It is thus possible to perform sophisticated computations (fits etc...) and to use the host disk space to store calibration results for later use. In spite of the use of assembly language, a software structure has been devised to ease the constitution of an application program. This is achieved by the interplay of three levels of facilities: macro-instructions, library of subroutines, and Patchy controlled pieces of programs. A comprehensive collection of these is kept in the form of PAM files on the host computer. This system has been used to test calorimeter modules for the UA 1 experiment. (orig.)

  17. A microprocessor based area monitor system for neutron and gamma radiation

    Wilhelm, R.; Heusser, G.

    1980-01-01

    The conventional electronics of the area monitors at the MPI-Heidelberg accelerators have been replaced by a microprocessor system consisting of individual detector-microprocessors and a central microcomputer. The detector microprocessors convert the count rates of BF3 and GM counter tubes into dose rates and control three different radiation thresholds (failure, low and high level). Different warning signals are operated directly by the detector processors, whereas the dose rates are transferred to the central microcomputer. Here the data are processed for recording on tape and displaying on TV monitors. The detector as well as the central processors have been developed on the basis of a 16-bit microprocessor. In the control rooms the dose rates of the individual monitors are displayed and on an indicator board showing the different locations, the high radiation level and the state of the doors (open, locked, and closed, locked but open) are sianaled by different LED. If a high radiation threshold is surpassed, the doors adjacent to that area can be locked either by switches on the indicator board or automatically. Within the experimental area, the low and high radiation level is indicated by acoustic and light signals. The whole concept permits keeping the absorbed doses of the personnel as low as possible without affecting the flexibility of the experimental operations. The independence of the microprocessor driven area monitors guarantees a high reliability. Compared to conventional electronics the advantages of the system are its reliability and cost. (Author)

  18. Scientific Impact of MODIS C5 Calibration Degradation and C6+ Improvements

    Lyapustin, A.; Wang, Y.; Xiong, X.; Meister, G.; Platnick, S.; Levy, R.; Franz, B.; Korkin, S.; Hilker, T.; Tucker, J.; hide

    2014-01-01

    The Collection 6 (C6) MODIS (Moderate Resolution Imaging Spectroradiometer) land and atmosphere data sets are scheduled for release in 2014. C6 contains significant revisions of the calibration approach to account for sensor aging. This analysis documents the presence of systematic temporal trends in the visible and near-infrared (500 m) bands of the Collection 5 (C5) MODIS Terra and, to lesser extent, in MODIS Aqua geophysical data sets. Sensor degradation is largest in the blue band (B3) of the MODIS sensor on Terra and decreases with wavelength. Calibration degradation causes negative global trends in multiple MODIS C5 products including the dark target algorithm's aerosol optical depth over land and Ångstrom exponent over the ocean, global liquid water and ice cloud optical thickness, as well as surface reflectance and vegetation indices, including the normalized difference vegetation index (NDVI) and enhanced vegetation index (EVI). As the C5 production will be maintained for another year in parallel with C6, one objective of this paper is to raise awareness of the calibration-related trends for the broad MODIS user community. The new C6 calibration approach removes major calibrations trends in the Level 1B (L1B) data. This paper also introduces an enhanced C6C calibration of the MODIS data set which includes an additional polarization correction (PC) to compensate for the increased polarization sensitivity of MODIS Terra since about 2007, as well as detrending and Terra- Aqua cross-calibration over quasi-stable desert calibration sites. The PC algorithm, developed by the MODIS ocean biology processing group (OBPG), removes residual scan angle, mirror side and seasonal biases from aerosol and surface reflectance (SR) records along with spectral distortions of SR. Using the multiangle implementation of atmospheric correction (MAIAC) algorithm over deserts, we have also developed a detrending and cross-calibration method which removes residual decadal trends on

  19. Neutron diffraction analysis of HRh[P(C6H5)3]4

    Bau, R.; Stevens, R.C.; McLean, M.; Koetzle, T.F.

    1987-01-01

    We have collected neutron diffraction data on a large single crystal of the title compound. The most surprising result is an extremely short Rh-H distance of 1.31(8) A, presumably caused by steric interactions involving the bulky triphenyl phosphine ligands. Crystallographic details: HRh[P(C 6 H 5 ) 3 ] 4 . 1 / 2 C 6 H 6 crystallizes in the space group Pa3, with a = b = c = 22.776(3) A, Z = 8. Data were collected at the Brookhaven High Flux Beam reactor at a temperature of -23 0 C, λ = 1.15882(7) A -1 . Least-squares refinement (in which the phenyl rings were treated as rigid groups) resulted in an R factor [based on data with f > 4σ(F)] of 0.12 for 914 reflections and 95 parameters. 10 refs

  20. Design, Synthesis and Biological Evaluation of C(6-Modified Celastrol Derivatives as Potential Antitumor Agents

    Kaiyong Tang

    2014-07-01

    Full Text Available New six C6-celastrol derivatives were designed, synthesized, and evaluated for their in vitro cytotoxic activities against nine human cancer cell lines (BGC-823, H4, Bel7402, H522, Colo 205, HepG2 and MDA-MB-468. The results showed that most of the compounds displayed potent inhibition against BGC823, H4, and Bel7402, with IC50s of 1.84–0.39 μM. The best compound NST001A was tested in an in vivo antitumor assay on nude mice bearing Colo 205 xenografts, and showed significant inhibition of tumor growth at low concentrations. Therefore, celastrol C-6 derivatives are potential drug candidates for treating cancer.

  1. Zero-Point Corrections for Isotropic Coupling Constants for Cyclohexadienyl Radical, C6H7 and C6H6Mu: Beyond the Bond Length Change Approximation

    Bruce S. Hudson

    2013-04-01

    Full Text Available Zero-point vibrational level averaging for electron spin resonance (ESR and muon spin resonance (µSR hyperfine coupling constants (HFCCs are computed for H and Mu isotopomers of the cyclohexadienyl radical. A local mode approximation previously developed for computation of the effect of replacement of H by D on 13C-NMR chemical shifts is used. DFT methods are used to compute the change in energy and HFCCs when the geometry is changed from the equilibrium values for the stretch and both bend degrees of freedom. This variation is then averaged over the probability distribution for each degree of freedom. The method is tested using data for the methylene group of C6H7, cyclohexadienyl radical and its Mu analog. Good agreement is found for the difference between the HFCCs for Mu and H of CHMu and that for H of CHMu and CH2 of the parent radical methylene group. All three of these HFCCs are the same in the absence of the zero point average, a one-parameter fit of the static HFCC, a(0, can be computed. That value, 45.2 Gauss, is compared to the results of several fixed geometry electronic structure computations. The HFCC values for the ortho, meta and para H atoms are then discussed.

  2. Cervical pedicle screw fixation at C6 and C7 A cadaveric study

    Ye Li

    2015-01-01

    Conclusion: The intersection of the horizontal line through the midpoint of the transverse process root and vertical line through the intersection of the posterolateral and posterior planes of the isthmus can be used as an entry point for C6 and C7 pedicle screw fixation. The screws should be inserted at 60 or 90° with the posterolateral isthmus in the horizontal plane and at 75° with the posterior isthmus in the sagittal plane. The LSC should not exceed 30 mm.

  3. Nqrs Data for C6H7F4N2OSb (Subst. No. 0879)

    Chihara, H.; Nakamura, N.

    This document is part of Subvolume A `Substances Containing Ag … C10H15' of Volume 48 `Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III `Condensed Matter'. It contains an extract of Section `3.2 Data tables' of the Chapter `3 Nuclear quadrupole resonance data' providing the NQRS data for C6H7F4N2OSb (Subst. No. 0879)

  4. Nqrs Data for C6H7F7N2OSb2 (Subst. No. 0880)

    Chihara, H.; Nakamura, N.

    This document is part of Subvolume A `Substances Containing Ag … C10H15' of Volume 48 `Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III `Condensed Matter'. It contains an extract of Section `3.2 Data tables' of the Chapter `3 Nuclear quadrupole resonance data' providing the NQRS data for C6H7F7N2OSb2 (Subst. No. 0880)

  5. Photoemission study of Ca-intercalated graphite superconductor CaC6

    Okazaki, Hiroyuki; Yoshida, Rikiya; Iwai, Keisuke; Noami, Kengo; Muro, Takayuki; Nakamura, Tetsuya; Wakita, Takanori; Muraoka, Yuji; Hirai, Masaaki; Tomioka, Fumiaki; Takano, Yoshihiko; Takenaka, Asami; Toyoda, Masahiro; Oguchi, Tamio; Yokoya, Takayoshi

    2010-01-01

    In this work, we have performed resonant photoemission studies of Ca-intercalated graphite superconductor CaC 6 . Using photon energy of the Ca 2p-3d threshold, the photoemission intensity of the peak at Fermi energy (E F ) is resonantly enhanced. This result provides spectroscopic evidence for the existence of Ca 3d states at E F , and strongly supports that Ca 3d state plays a crucial role for the superconductivity of this material with relatively high T c .

  6. MRI and morphological observation in C6 glioma model rats and significance

    Zhou Ying; Yuan Bo; Wang Hao; Lu Jin; Yuan Changji; Ma Yue; Tong Dan; Zhang Kun; Gao Feng; Wu Xiaogang

    2013-01-01

    Objective: To establish stable and reliable rat C6 glioma model, and to perform MRI dynamic observation and pathomorphological observation in model animal brain, and to provide experimental basis for pharmaceutical research on anti-glioma drugs. Methods: The C6 glioma cells were cultured and 20 μL cultural fluid containing 1×10 6 C6 cells was sterotactically implanted into the left caudate nuclei in 10 male Wistar rats, respectively. The changes in the behavior of the rats after implantation were observed and recorded. MRI dynamic scanning was performed in 10 rats 2, 3 and 4 weeks after implantation and the brain tissues were taken for general and pathological examination when the 10 rats were naturally dead. The survival period of tumor-bearing rats was calculated. Results: 2 weeks after implantation the rats showed decreased activities and food intake, fur lackluster, and conjunctival congestion and so on; 3 weeks later, some rats appeared nerve symptoms such as body twitch, body hemiplegy, body distortion, rotation and so on. All the 10 rats died in 8-30 d. The median survival period of the tumor-bearing rats was 18 d, the average survival period was (18.3±7.3) d. The pathological examination showed that the tumor cells were arranged irregularly closely and karyokinesis was easy to see; tumor vascular tissue proliferation and tumor invasive growth into surrounding normal tissues were found. The expression of glial fibrillary acidic protein (GFAP) was positive in the tumors. Conclusion: A stable animal model of intracranial glioma is successfully established by stereotactic implantation of C6 cells into the rat caudate nucleus. The results of MRI dynamic observation and pathohistological observation on the model animal brain tissue. Can provide experimental basis for selecting the appropriate time window to perform the pharmaceutical research on anti-glioma drugs. (authors)

  7. Ebselen Induced C6 Glioma Cell Death in Oxygen and Glucose Deprivation

    Shi, Honglian; Liu, Shimin; Miyake, Minoru; Liu, Ke Jian

    2006-01-01

    Studies have shown that ebselen is an anti-inflammatory and antioxidative agent. Its protective effect has been investigated in oxidative stress related diseases such as cerebral ischemia in recent years. However, experimental evidence also shows that ebselen causes cell death in several different cell types. Whether ebselen will have beneficial or detrimental effect on cells under ischemic condition is not known. Herein, we studied the effect of ebselen on C6 glioma cell under oxygen and glu...

  8. Synthesis of [13C6]-labelled phenethylamine derivatives for drug quantification in biological samples.

    Karlsen, Morten; Liu, HuiLing; Berg, Thomas; Johansen, Jon Eigill; Hoff, Bård Helge

    2014-05-15

    The availability of high-quality (13)C-labelled internal standards will improve accurate quantification of narcotics and drugs in biological samples. Thus, the synthesis of 10 [(13)C6]-labelled phenethylamine derivatives, namely amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxy-N-ethylamphetamine, 4-methoxyamphetamine, 4-methoxymethamphetamine, 3,5-dimethoxyphenethylamine 4-bromo-2,5-dimethoxyphenethylamine and 2,5-dimethoxy-4-iodophenethylamine, have been undertaken. [(13)C6]-Phenol proved to be an excellent starting material for making (13)C-labelled narcotic substances in the phenethylamine class, and a developed Stille-type coupling enabled an efficient synthesis of the 3,4-methylenedioxy and 4-methoxy derivatives. The pros and cons of alternative routes and transformations are also discussed. The [(13)C6]-labelled compounds are intended for use as internal standards in forensic analysis, health sciences and metabolomics studies by gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry. Copyright © 2014 John Wiley & Sons, Ltd.

  9. Oleic Acid and Hydroxytyrosol Inhibit Cholesterol and Fatty Acid Synthesis in C6 Glioma Cells

    Paola Priore

    2017-01-01

    Full Text Available Recently, the discovery of natural compounds capable of modulating nervous system function has revealed new perspectives for a healthier brain. Here, we investigated the effects of oleic acid (OA and hydroxytyrosol (HTyr, two important extra virgin olive oil compounds, on lipid synthesis in C6 glioma cells. OA and HTyr inhibited both de novo fatty acid and cholesterol syntheses without affecting cell viability. The inhibitory effect of the individual compounds was more pronounced if OA and HTyr were administered in combination. A reduction of polar lipid biosynthesis was also detected, while triglyceride synthesis was marginally affected. To clarify the lipid-lowering mechanism of these compounds, their effects on the activity of key enzymes of fatty acid biosynthesis (acetyl-CoA carboxylase-ACC and fatty acid synthase-FAS and cholesterologenesis (3-hydroxy-3-methylglutaryl-CoA reductase-HMGCR were investigated in situ by using digitonin-permeabilized C6 cells. ACC and HMGCR activities were especially reduced after 4 h of 25 μM OA and HTyr treatment. No change in FAS activity was observed. Inhibition of ACC and HMGCR activities is corroborated by the decrease of their mRNA abundance and protein level. Our results indicate a direct and rapid downregulatory effect of the two olive oil compounds on lipid synthesis in C6 cells.

  10. Undersulfation of proteoglycans and proteins alter C6 glioma cells proliferation, adhesion and extracellular matrix organization.

    Mendes de Aguiar, Claudia B N; Garcez, Ricardo Castilho; Alvarez-Silva, Marcio; Trentin, Andréa Gonçalves

    2002-11-01

    Proteoglycans are considered to be important molecule in cell-microenvironment interactions. They are overexpressed in neoplastic cells modifying their growth and migration in hosts. In this work we verified that undersulfation of proteoglycans and other sulfated molecules, induced by sodium chlorate treatment, inhibited C6 glioma cells proliferation in a dose-dependent way. This effect was restored by the addition of exogenous heparin. We could not detect significant cell mortality in our culture condition. The treatment also impaired in a dose-dependent manner, C6 cell adhesion to extracellular matrix (ECM) proteins (collagen IV, laminin and fibronectin). In addition, sodium chlorate treatment altered C6 glioma cell morphology, from the fibroblast-like to a more rounded one. This effect was accompanied by increased synthesis of fibronectin and alterations in its extracellular network organization. However, we could not observe modifications on laminin organization and synthesis. The results suggest an important connection between sulfation degree with important tumor functions, such as proliferation and adhesion. We suggest that proteoglycans may modulate the glioma microenvironment network during tumor cell progression and invasion.

  11. Extracellular diffusion quantified by magnetic resonance imaging during rat C6 glioma cell progression

    G. Song

    Full Text Available Solution reflux and edema hamper the convection-enhanced delivery of the standard treatment for glioma. Therefore, a real-time magnetic resonance imaging (MRI method was developed to monitor the dosing process, but a quantitative analysis of local diffusion and clearance parameters has not been assessed. The objective of this study was to compare diffusion into the extracellular space (ECS at different stages of rat C6 gliomas, and analyze the effects of the extracellular matrix (ECM on the diffusion process. At 10 and 20 days, after successful glioma modeling, gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA was introduced into the ECS of rat C6 gliomas. Diffusion parameters and half-life of the reagent were then detected using MRI, and quantified according to the mathematical model of diffusion. The main ECM components [chondroitin sulfate proteoglycans (CSPGs, collagen IV, and tenascin C] were detected by immunohistochemical and immunoblot analyses. In 20-day gliomas, Gd-DTPA diffused more slowly and derived higher tortuosity, with lower clearance rate and longer half-life compared to 10-day gliomas. The increased glioma ECM was associated with different diffusion and clearance parameters in 20-day rat gliomas compared to 10-day gliomas. ECS parameters were altered with C6 glioma progression from increased ECM content. Our study might help better understand the glioma microenvironment and provide benefits for interstitial drug delivery to treat brain gliomas.

  12. Médicarte software developed for the Quebec microprocessor health card project.

    Lavoie, G; Tremblay, L; Durant, P; Papillon, M J; Bérubé, J; Fortin, J P

    1995-01-01

    The Quebec Patient Smart Card Project is a Provincial Government initiative under the responsibility of the Rgie de l'assurance-maladie du Québec (Quebec Health Insurance Board). Development, implementation, and assessment duties were assigned to a team from Université Laval, which in turn joined a group from the Direction de la santé publique du Bas-St-Laurent in Rimouski, where the experiment is taking place. The pilot project seeks to evaluate the use and acceptance of a microprocessor card as a way to improve the exchange of clinical information between card users and various health professionals. The card can be best described as a résumé containing information pertinent to an individual's health history. It is not a complete medical file; rather, it is a summary to be used as a starting point for a discussion between health professionals and patients. The target population is composed of persons 60 years and over, pregnant women, infants under 18 months, and the residents of a small town located in the target area, St-Fabien, regardless of age. The health professionals involved are general practitioners, specialists, pharmacists, nurses, and ambulance personnel. Participation in the project is on a voluntary basis. Each health care provider participating in the project has a personal identification number (PIN) and must use both an access card and a user card to access information. This prevents unauthorized access to a patient's card and allows the staff to sign and date information entered onto the patient card. To test the microprocessor card, we developed software based on a problem-oriented approach integrating diagnosis, investigations, treatments, and referrals. This software is not an expert system that constrains the clinician to a particular decisional algorithm. Instead, the software supports the physician in decision making. The software was developed with a graphical interface (Windows 3.1) to maximize its user friendliness. A version of the

  13. A Mathematical Model for Simultaneous Saccharification and Co-fermentation (SSCF) of C6 and C5 Sugars

    Morales Rodriguez, Ricardo; Gernaey, Krist; Meyer, Anne S.

    2011-01-01

    saccharification and co-fermentation (SSCF) of C6 and C5 sugars. The model is constructed by combining existing mathematical models for enzymatic hydrolysis and co-fermentation. An inhibition of ethanol on cellulose conversion is introduced in order to increase the reliability. The mathematical model for the SSCF...... is verified by comparing the model predictions with experimental data obtained from the ethanol production based on kraft paper mill sludge. When fitting the model to the data, only the yield coefficients for glucose and xylose metabolism were fine-tuned, which were found to be 0.43 g·g−1 (ethanol....../glucose) and 0.35 g·g−1 (ethanol/xylose) respectively. These promising validation results encourage further model application to evaluate different process configurations for lignocellulosic bioethanol technology....

  14. Microprocessor, Setx, Xrn2, and Rrp6 Co-operate to Induce Premature Termination of Transcription by RNAPII

    Wagschal, Alexandre; Rousset, Emilie; Basavarajaiah, Poornima; Contreras, Xavier; Harwig, Alex; Laurent-Chabalier, Sabine; Nakamura, Mirai; Chen, Xin; Zhang, Ke; Meziane, Oussama; Boyer, Frédéric; Parrinello, Hugues; Berkhout, Ben; Terzian, Christophe; Benkirane, Monsef; Kiernan, Rosemary

    2012-01-01

    Transcription elongation is increasingly recognized as an important mechanism of gene regulation. Here, we show that microprocessor controls gene expression in an RNAi-independent manner. Microprocessor orchestrates the recruitment of termination factors Setx and Xrn2, and the 30-50 exoribonuclease,

  15. Distributed Microprocessor Automation Network for Synthesizing Radiotracers Used in Positron Emission Tomography [PET

    Russell, J. A. G.; Alexoff, D. L.; Wolf, A. P.

    1984-09-01

    This presentation describes an evolving distributed microprocessor network for automating the routine production synthesis of radiotracers used in Positron Emission Tomography. We first present a brief overview of the PET method for measuring biological function, and then outline the general procedure for producing a radiotracer. The paper identifies several reasons for our automating the syntheses of these compounds. There is a description of the distributed microprocessor network architecture chosen and the rationale for that choice. Finally, we speculate about how this network may be exploited to extend the power of the PET method from the large university or National Laboratory to the biomedical research and clinical community at large. (DT)

  16. Optimization of Reciprocals and Square Roots on the i860 Microprocessor

    Sinclair, Robert

    1996-01-01

    The i860 microprocessor lacks both a divide and a square root instruction. The consequences of this for code involving many reciprocal square roots, such as many-body simulations involving Coulomb-like potentials, are discussed with a particular emphasis on high performance.......The i860 microprocessor lacks both a divide and a square root instruction. The consequences of this for code involving many reciprocal square roots, such as many-body simulations involving Coulomb-like potentials, are discussed with a particular emphasis on high performance....

  17. Distributed microprocessor automation network for synthesizing radiotracers used in positron emission tomography

    Russell, J.A.G.; Alexoff, D.L.; Wolf, A.P.

    1984-01-01

    This presentation describes an evolving distributed microprocessor network for automating the routine production synthesis of radiotracers used in Positron Emission Tomography. We first present a brief overview of the PET method for measuring biological function, and then outline the general procedure for producing a radiotracer. The paper identifies several reasons for our automating the syntheses of these compounds. There is a description of the distributed microprocessor network architecture chosen and the rationale for that choice. Finally, we speculate about how this network may be exploited to extend the power of the PET method from the large university or National Laboratory to the biomedical research and clinical community at large. 20 refs. (DT)

  18. Design description of a microprocessor based Engine Monitoring and Control unit (EMAC) for small turboshaft

    Baez, A. N.

    1985-01-01

    Research programs have demonstrated that digital electronic controls are more suitable for advanced aircraft/rotorcraft turbine engine systems than hydromechanical controls. Commercially available microprocessors are believed to have the speed and computational capability required for implementing advanced digital control algorithms. Thus, it is desirable to demonstrate that off-the-shelf microprocessors are indeed capable of performing real time control of advanced gas turbine engines. The engine monitoring and control (EMAC) unit was designed and fabricated specifically to meet the requirements of an advanced gas turbine engine control system. The EMAC unit is fully operational in the Army/NASA small turboshaft engine digital research program.

  19. The micro-processor controlled process radiation monitoring system for reactor safety systems

    Mizuno, K.; Noguchi, A.; Kumagami, S.; Gotoh, Y.; Kumahara, T.; Arita, S.

    1986-01-01

    Digital computers are soon expected to be applied to various real-time safety and safety-related systems in nuclear power plants. Hitachi is now engaged in the development of a micro-processor controlled process radiation monitoring system, which operates on digital processing methods employed with a log ratemeter. A newly defined methodology of design and test procedures is being applied as a means of software program verification for these safety systems. Recently implemented micro-processor technology will help to achieve an advanced man-machine interface and highly reliable performance. (author)

  20. Complexation of c6-ceramide with cholesteryl phosphocholine - a potent solvent-free ceramide delivery formulation for cells in culture.

    Pramod Sukumaran

    Full Text Available Ceramides are potent bioactive molecules in cells. However, they are very hydrophobic molecules, and difficult to deliver efficiently to cells. We have made fluid bilayers from a short-chain D-erythro-ceramide (C6-Cer and cholesteryl phosphocholine (CholPC, and have used this as a formulation to deliver ceramide to cells. C6-Cer complexed with CholPC led to much larger biological effects in cultured cells (rat thyroid FRTL-5 and human HeLa cells in culture compared to C6-Cer dissolved in dimethyl sulfoxide (DMSO. Inhibition of cell proliferation and induction of apoptosis was significantly more efficient by C6-Cer/CholPC compared to C6-Cer dissolved in DMSO. C6-Cer/CholPC also permeated cell membranes and caused mitochondrial Ca(2+ influx more efficiently than C6-Cer in DMSO. Even though CholPC was taken up by cells to some extent (from C6-Cer/CholPC bilayers, and was partially hydrolyzed to free cholesterol (about 9%, none of the antiproliferative effects were due to CholPC or excess cholesterol. The ceramide effect was not limited to D-erythro-C6-Cer, since L-erythro-C6-Cer and D-erythro-C6-dihydroCer also inhibited cell priolifereation and affected Ca(2+ homeostasis. We conclude that C6-Cer complexed to CholPC increased the bioavailability of the short-chain ceramide for cells, and potentiated its effects in comparison to solvent-dissolved C6-Cer. This new ceramide formulation appears to be superior to previous solvent delivery approaches, and may even be useful with longer-chain ceramides.

  1. Analysis on Biomechanical Characteristics of Post-operational Vertebral C5-C6 Segments

    Heqiang Tian

    2016-03-01

    Full Text Available Both anterior cervical decompression and fusion (ACDF and artificial cervical disc replacement (ACDR have obvious advantages in the treatment of cervical spondylosis. To analyze the operation results, it is absolutely necessary to study the biomechanics of the movement range of post-operational vertebral C5-C6 segments, especially the biomechanical characteristics in cervical tissues in actual movements. In this study, using the human vertebral 3D graph gained by imaging diagnosis (CT, a vertebral solid model is established by the 3D reconstruction algorithm and reverse engineering technology. After that, with cervical soft tissue structure added to the solid model and set with a joint contact mechanism, a finite element model with a complete, accurate cervical C5-C6 kinematic unit is constructed, based on relevant physiological anatomical knowledge. This model includes vertebral segments, an intervertebral disc, ligament and zygopophysis in the cervical C5-C6 kinematic unit. In the created vertebral finite element model, the model is amended, referring to ACDF and ACDR, and the load and constraint are applied to a normal group, a fusion group and a displacement group, so as to analyze the biomechanical characteristics of the cervical vertebra after ACDF and ACDR. By comparing the finite element simulation results of different surgeries, this paper is intended to evaluate the functions and biomechanical behaviors of the post-operational vertebra, and explore the influence of the operation on the biomechanical stability of the cervical vertebra. This will provide theoretical guidance for implementation and optimization of ACDF and ACDR.

  2. Solvent extraction of Pu(IV) with TODGA in C6mimTf2N

    Xiaohong Huang; Qiuyue Zhang; Jinping Liu; Hui He; Wenbin Zhu; Xiaorong Wang

    2013-01-01

    Studies on the solvent extraction of Plutonium(Pu(IV)) from aqueous nitric acid by N,N,N'N'tetraoctyl-diglycolamide (TODGA) in 1-hexyl-3-methylimidazolium-bis(trifluoromethylsulfonyl) imide (C 6 mimTf 2 N) room temperature ionic liquid (RTIL) were carried out. It was found that Pu(IV) is extracted into RTIL phase as [Pu(NO 3 )(TODGA)] 3+ through cation exchange mechanism. Extraction reaction equation is obtained by the influence of acidity and extractant concentration, and the parameters of thermodynamic equilibrium constant was calculated. (author)

  3. 16O resonances near 4α threshold through 12C(6Li,d) reaction

    Rodrigues, M. R. D.; Borello-Lewin, T.; Miyake, H.; Horodynski-Matsushigue, L. B.; Duarte, J. L. M.; Rodrigues, C. L.; Faria, P. Neto de; Cunsolo, A.; Cappuzzello, F.; Foti, A.; Agodi, C.; Cavallaro, M.; Napoli, M. di; Ukita, G. M.

    2014-01-01

    Several narrow alpha resonant 16 O states were detected through the 12 C( 6 Li,d) reaction, in the range of 13.5 to 17.5 MeV of excitation energy. The reaction was measured at a bombarding energy of 25.5 MeV employing the São Paulo Pelletron-Enge-Spectrograph facility and the nuclear emulsion technique. Experimental angular distributions associated with natural parity quasi-bound states around the 4α threshold are presented and compared to DWBA predictions. The upper limit for the resonance widths obtained is near the energy resolution (15 keV)

  4. 16O resonances near 4α threshold through 12C (6Li,d ) reaction

    Rodrigues, M. R. D.; Borello-Lewin, T.; Miyake, H.; Horodynski-Matsushigue, L. B.; Duarte, J. L. M.; Rodrigues, C. L.; de Faria, P. Neto; Cunsolo, A.; Cappuzzello, F.; Foti, A.; Agodi, C.; Cavallaro, M.; di Napoli, M.; Ukita, G. M.

    2014-11-01

    Several narrow alpha resonant 16O states were detected through the 12C (6Li,d ) reaction, in the range of 13.5 to 17.5 MeV of excitation energy. The reaction was measured at a bombarding energy of 25.5 MeV employing the São Paulo Pelletron-Enge-Spectrograph facility and the nuclear emulsion technique. Experimental angular distributions associated with natural parity quasi-bound states around the 4α threshold are presented and compared to DWBA predictions. The upper limit for the resonance widths obtained is near the energy resolution (15 keV).

  5. Ejected electron energy distribution in the ionization of atomic hydrogen by C6+ impact

    Dey, Ritu; Roy, A.C.

    2006-01-01

    We report doubly differential cross section (DDCS) for C 6+ impact ionization of atomic hydrogen at the incident energy of 2.5 MeV/amu. The calculation is based on the eikonal approximation (EA) method. A comparison is made of the present DDCS with the results of other theoretical methods and experiment. It is found that the multiple scattering effect has a significant influence on the energy distributions of the ejected electrons. The cross sections predicted by the present EA also show reasonably good agreement with experiment

  6. Ab initio calculation of the voltage profile for LiC6

    Kganyago, KR

    2003-03-01

    Full Text Available , Council for the Scientific and Industrial Research, Pretoria, 0001, South Africa c Davy Faraday Research Laboratory, The Royal Institution of Great Britain, 21 Albemarle Street, London W1S 4BS, UK Received 12 March 2002; received in revised form 10 June....2 Faraday per mole and the cyclable charge x is around 0.5 [1].Theanode reaction can be summarised as: xLi? ?xeC0 ?6C ? LixC6 ?1? In this communication, we explore the contribution to the voltage by the anode material using first- principles electronic...

  7. Replacement of the control and instrumentation system with the microprocessor based systems in Japanese PWR plants

    Hayashi, N.

    1998-01-01

    In Ohi Units 3 and 4, Ikata Unit 3, and Genkai Units 3 and 4, the latest of PWR plants now under operation in Japan, the reactor control system and turbine control system employ the microprocessor base digital control systems with a view to improving reliability, operability and maintainability. In the next stage plants, another application of such digital system is also planned for the instrumentation rack for the reactor protection system for further improvement. On the other hand, in Mihama Unit 1, the first of domestic PWR plants, and later plants except for the latest 5 plants, analog control systems are employed for the instrumentation racks. For the analog control systems of these plants, FOXBORO H-Line instruments, equivalent domestic box type instruments or WH7300 Series card type instruments were initially employed, and later replaced with domestic card type control systems after 10-15 year operation. However, 8-12 years have passed since these replacements, so the 15th year generally quoted as an interval for replacing C and I systems is near at hand. This is the time to consider next replacement. This replacement will be based on the latest digital technology. However, it is not practical way for the existing plants to apply the same integrated digital C and I system configuration for the next stage plants, because it requires the drastic change of the C and I system configuration and significant cost-up. Therefore, we must investigate the optimum digital C and I system configuration for the existing system. (author)

  8. Metabolic effect of streptomyces avermitilis irradiated by ion beam of "1"2C"6"+

    Wang Shuyang; Chen Jihong; Li Wenjian; Liang Jianping; Liu Jing; Bo Yongheng; Wang Lihua

    2013-01-01

    pH value, mycelium concentration, carbon source and nitrogen metabolism in flask fermentation of the mutant high-producing strain ZJAV-Yl-203 and the original strain ZJAV-A1 have been investigated, in order to show the metabolic effect of avermitilis irradiated by ion beam of "1"2C"6"+. In early stage (48 h) of the fermentation, pH value of the original fermentation was lower than that of the mutant strains. In 96∼196 h of fermentation, the nitrogen utilization in the strains ZJAV-Y1-203 was higher than that in the original strains, its reproductive was fast, and its growing was vigorous. The mycelium concentration of ZJAV-Yl-203 was greater than the original strain, and the pH value of fermentation were stable, so its metabolism was relatively more stable. In 144∼240 h of fermentation, the strain ZJAV-Y1-203 on sugar consumption was less than the original strains. The effect of "1"2C"6"+ ion irradiation on metabolism of Streptomyces avermitilis is conducive to the synthesis of avermectin. (authors)

  9. Covalent functionalization of octagraphene with magnetic octahedral B6- and non-planar C6- clusters

    Chigo-Anota, E.; Cárdenas-Jirón, G.; Salazar Villanueva, M.; Bautista Hernández, A.; Castro, M.

    2017-10-01

    The interaction between the magnetic boron octahedral (B6-) and non-planar (C6-) carbon clusters with semimetal nano-sheet of octa-graphene (C64H24) in the gas phase is studied by means of DFT calculations. These results reveal that non-planar-1 (anion) carbon cluster exhibits structural stability, low chemical reactivity, magnetic (1.0 magneton bohr) and semiconductor behavior. On the other hand, there is chemisorption phenomena when the stable B6- and C6- clusters are absorbed on octa-graphene nanosheets. Such absorption generates high polarity and the low-reactivity remains as on the individual pristine cases. Electronic charge transference occurs from the clusters toward the nanosheets, producing a reduction of the work function for the complexes and also induces a magnetic behavior on the functionalized sheets. The quantum descriptors obtained for these systems reveal that they are feasible candidates for the design of molecular circuits, magnetic devices, and nano-vehicles for drug delivery.

  10. In vivo detection of c-Met expression in a rat C6 glioma model.

    Towner, R A; Smith, N; Doblas, S; Tesiram, Y; Garteiser, P; Saunders, D; Cranford, R; Silasi-Mansat, R; Herlea, O; Ivanciu, L; Wu, D; Lupu, F

    2008-01-01

    The tyrosine kinase receptor, c-Met, and its substrate, the hepatocyte growth factor (HGF), are implicated in the malignant progression of glioblastomas. In vivo detection of c-Met expression may be helpful in the diagnosis of malignant tumours. The C6 rat glioma model is a widely used intracranial brain tumour model used to study gliomas experimentally. We used a magnetic resonance imaging (MRI) molecular targeting agent to specifically tag the cell surface receptor, c-Met, with an anti-c-Met antibody (Ab) linked to biotinylated Gd (gadolinium)-DTPA (diethylene triamine penta acetic acid)-albumin in rat gliomas to detect overexpression of this antigen in vivo. The anti-c-Met probe (anti-c-Met-Gd-DTPA-albumin) was administered intravenously, and as determined by an increase in MRI signal intensity and a corresponding decrease in regional T(1) relaxation values, this probe was found to detect increased expression of c-Met protein levels in C6 gliomas. In addition, specificity for the binding of the anti-c-Met contrast agent was determined by using fluorescence microscopic imaging of the biotinylated portion of the targeting agent within neoplastic and 'normal'brain tissues following in vivo administration of the anti-c-Met probe. Controls with no Ab or with a normal rat IgG attached to the contrast agent component indicated no non-specific binding to glioma tissue. This is the first successful visualization of in vivo overexpression of c-Met in gliomas.

  11. Isolation of the antibiotic pseudopyronine B and SAR evaluation of C3/C6 alkyl analogs.

    Bouthillette, Leah M; Darcey, Catherine A; Handy, Tess E; Seaton, Sarah C; Wolfe, Amanda L

    2017-06-15

    Natural products are an abundant source of structurally diverse compounds with antibacterial activity that can be used to develop new and potent antibiotics. One such class of natural products is the pseudopyronines. Here we present the isolation of pseudopyronine B (2) from a Pseudomonas species found in garden soil in Western North Carolina, and SAR evaluation of C3 and C6 alkyl analogs of the natural product for antibacterial activity against Gram-positive and Gram-negative bacteria. We found a direct relationship between antibacterial activity and C3/C6 alkyl chain length. For inhibition of Gram-positive bacteria, alkyl chain lengths between 6 and 7 carbons were found to be the most active (IC 50 =0.04-3.8µg/mL) whereas short alkyl chain analogs showed modest activity against Gram-negative bacteria (IC 50 =223-304µg/mL). This demonstrates the potential for this class of natural products to be optimized for selective activity against either Gram-positive or Gram-negative bacteria. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Reliability of microprocessor-based relay protection devices: Myths and reality

    Gurevich Vladimir

    2009-01-01

    Full Text Available The article examines four basic theses about the ostensibly extremely high reliability of microprocessor-based relay protection (MP touted by supporters of MP. Through detailed analysis based on many references it is shown that the basis of these theses are widespread myths, and actually MP reliability is lower than the reliability of electromechanical and electronic protective relays on discrete components.

  13. Microprocessor control unit of thyristor regulator of microhydroelectric power station ballast load

    Nomokonova, Yu; Bogdanov, E

    2014-01-01

    The operational principle of microhydroelectric power station ballast load is presented. The comparative overview of the mathematical modeling methods is performed. The ranges of thyristors optimal work are shown as a result of the regulator regimes analysis. Shows the necessity of regulation the ballast load in microhydroelectric power station with help of developed algorithm of the program for microprocessor control

  14. A new design approach for control circuits of pipelined single-flux-quantum microprocessors

    Yamanashi, Y; Akimoto, A; Yoshikawa, N; Tanaka, M; Kawamoto, T; Kamiya, Y; Fujimaki, A; Terai, H; Yorozu, S

    2006-01-01

    A novel method of design for controllers of pipelined microprocessors using single-flux-quantum (SFQ) logic has been proposed. The proposed design approach is based on one hot encoding and is very suitable for designing a finite state machine using SFQ logic circuits, where each internal state of the microprocessor is represented by a flip-flop. In this approach, decoding of the internal state can be performed instantaneously, in contrast to the case in the conventional method using a binary state register. Moreover, pipelining is effectively implemented without increasing the circuit size because no pipeline registers are required in the one hot encoding. By using this method, we have designed a controller for our new SFQ microprocessors, which employs pipelining. The number of Josephson junctions of the newly designed controller is 1067, while the previous version without pipelining contains 1721 Josephson junctions. These results indicate that the proposed design approach is very effective for pipelined SFQ microprocessors. We have implemented a new controller using the NEC 2.5 kA cm -2 Nb standard process and confirmed its correct operation experimentally

  15. Instrument for bone mineral measurement using a microprocessor as the control and arithmetic element

    Alberi, J.L.; Hardy, W.H. II.

    1975-11-01

    A self-contained instrument for the determination of bone mineral content by photon absorptometry is described. A high-resolution detection system allows measurements to be made at up to 16 photon energies. Control and arithmetic functions are performed by a microprocessor. Analysis capability and limitations are discussed

  16. Design of microprocessor data acquisition system for pedestrian portal SNM monitor

    Zhang Wenliang

    2003-01-01

    The paper introduces the hardware structure and composition of data acquisition system for pedestrian portal special nuclear material (SNM) monitor. The hardware and software of single chip microprocessor AT89C52, LCM, keyboard and serial communication interface software are also discussed. (authors)

  17. Adapting to change: influence of a microprocessor-controlled prosthetic knee on gait adaptations

    Prinsen, Erik Christiaan

    2016-01-01

    Advancement in prosthetic knee design have led to the introduction of microprocessor-controlled prosthetic knees (MPKs). MPKs incorporate sensors that are able to measure prosthetic loading, the knee angle, and knee angular velocity. Based on the sensor information, MPKs determine the optimal level

  18. A CAMAC-resident microprocessor for the monitoring of polarimeter spin states

    Reid, D.; DuPlantis, D.; Yoder, N.; Dale, D.

    1992-01-01

    A CAMAC module for the reporting of polarimeter spin states is being developed using a resident microcontroller. The module will allow experimenters at the Indiana University Cyclotron Facility to monitor spin states and correlate spin information with other experimental data. The use of a microprocessor allows for adaptation of the module as new requirements ensue without change to the printed circuit board layout. (author)

  19. Microprocessor system for data acquisition processing and display for Auger electrons spectrometer

    Pawlowski, Z.; Cudny, W.; Hildebrandt, S.; Marzec, J.; Walentek, J.; Zaremba, K.

    1984-01-01

    Data acquisition system for Auger electron spectrometry is developed. The system is used for chemical and structural analysis of materials and consists of a cylindrical mirror analyzer being a measuring spectrometer device, CAMAC unit and control unit. The control unit comprises a microcomputer based on INTEL 8080 microprocessor and display

  20. The design of an asynchronous Tiny RISC TM/TR4101 microprocessor core

    Christensen, Kåre Tais; Jensen, P.; Korger, P.

    1998-01-01

    This paper presents the design of an asynchronous version of the TR4101 embedded microprocessor core developed by LSI Logic Inc. The asynchronous processor, called ARISC, was designed using the same CAD tools and the same standard cell library that was used to implement the TR4101. The paper repo...

  1. Architectural and compiler techniques for energy reduction in high-performance microprocessors

    Bellas, Nikolaos

    1999-11-01

    The microprocessor industry has started viewing power, along with area and performance, as a decisive design factor in today's microprocessors. The increasing cost of packaging and cooling systems poses stringent requirements on the maximum allowable power dissipation. Most of the research in recent years has focused on the circuit, gate, and register-transfer (RT) levels of the design. In this research, we focus on the software running on a microprocessor and we view the program as a power consumer. Our work concentrates on the role of the compiler in the construction of "power-efficient" code, and especially its interaction with the hardware so that unnecessary processor activity is saved. We propose techniques that use extra hardware features and compiler-driven code transformations that specifically target activity reduction in certain parts of the CPU which are known to be large power and energy consumers. Design for low power/energy at this level of abstraction entails larger energy gains than in the lower stages of the design hierarchy in which the design team has already made the most important design commitments. The role of the compiler in generating code which exploits the processor organization is also fundamental in energy minimization. Hence, we propose a hardware/software co-design paradigm, and we show what code transformations are necessary by the compiler so that "wasted" power in a modern microprocessor can be trimmed. More specifically, we propose a technique that uses an additional mini cache located between the instruction cache (I-Cache) and the CPU core; the mini cache buffers instructions that are nested within loops and are continuously fetched from the I-Cache. This mechanism can create very substantial energy savings, since the I-Cache unit is one of the main power consumers in most of today's high-performance microprocessors. Results are reported for the SPEC95 benchmarks in the R-4400 processor which implements the MIPS2 instruction

  2. Study of the M23C6 precipitation in AISI 304 stainless steel by small angle neutron scattering

    Boeuf, A.; Caciuffo, R.G.M.; Institut Max von Laue - Paul Langevin, 38 - Grenoble; Ancona Univ.; Melone, S.; Puliti, P.; Rustichelli, F.; Institut Max von Laue - Paul Langevin, 38 - Grenoble; Ancona Univ.; Coppola, R.

    1985-01-01

    The results of some small-angle neutron scattering (SANS) experiments on M 23 C 6 (M=Fe, Cr) carbide precipitation in AISI 304 stainless steel, aged at different temperatures during different times, are presented. The total volume fraction, the total surface of precipitates per unit sample volume and the size distribution functions of the M 23 C 6 carbides were determined. (orig.)

  3. Unilateral hyperplasia of the left posterior arch and associated vertebral schisis at C6 level

    Esposito, Giuseppe; Bonis, Pasquale de; Tamburrini, Gianpiero; Massimi, Luca; Rocco, Concezio di [Catholic University, School of Medicine, Department of Pediatric Neurosurgery, Rome (Italy); Byvaltsev, Vadim [Irkutsk Railway Clinical Hospital, Department of Neurosurgery, Irkutsk (Russian Federation); Leone, Antonio [Catholic University, School of Medicine, Department of Bioimaging and Radiological Sciences, Rome (Italy)

    2009-12-15

    We report on a 5-year-old girl with unilateral hyperplasia of the left posterior arch of C6 associated with spina bifida occulta at the same level. Anteroposterior and lateral radiographs of the cervical spine showed hypertrophy of the left lamina as well as overgrowth and elongation of the left spinous process of the sixth cervical vertebra. Computed tomography (CT) examination better depicted this congenital variant and clearly showed the associated schisis of the posterior arch at the same level. Magnetic resonance (MR) imaging examination ruled out other spinal anomalies. The neck pain, the young age of the patient and the local aesthetic abnormality contributed to the surgical indication. To the best of our knowledge, this is the first case in the English literature of unilateral hyperplasia of a posterior cervical arch. Only one previous study has reported a similar congenital anomaly, but it was limited to the left side of the spinous process. (orig.)

  4. Development of C6+ laser ion source and RFQ linac for carbon ion radiotherapy

    Sako, T.; Yamaguchi, A.; Sato, K.; Goto, A.; Iwai, T.; Nayuki, T.; Nemoto, K.; Kayama, T.; Takeuchi, T.

    2016-02-01

    A prototype C6+ injector using a laser ion source has been developed for a compact synchrotron dedicated to carbon ion radiotherapy. The injector consists of a laser ion source and a 4-vane radio-frequency quadrupole (RFQ) linac. Ion beams are extracted from plasma and directly injected into the RFQ. A solenoid guides the low-energy beams into the RFQ. The RFQ is designed to accelerate high-intensity pulsed beams. A structure of monolithic vanes and cavities is adopted to reduce its power consumption. In beam acceleration tests, a solenoidal magnetic field set between the laser ion source and the RFQ helped increase both the peak currents before and after the RFQ by a factor of 4.

  5. Development of C6+ laser ion source and RFQ linac for carbon ion radiotherapy

    Sako, T.; Yamaguchi, A.; Sato, K.; Goto, A.; Iwai, T.; Nayuki, T.; Nemoto, K.; Kayama, T.; Takeuchi, T.

    2016-01-01

    A prototype C 6+ injector using a laser ion source has been developed for a compact synchrotron dedicated to carbon ion radiotherapy. The injector consists of a laser ion source and a 4-vane radio-frequency quadrupole (RFQ) linac. Ion beams are extracted from plasma and directly injected into the RFQ. A solenoid guides the low-energy beams into the RFQ. The RFQ is designed to accelerate high-intensity pulsed beams. A structure of monolithic vanes and cavities is adopted to reduce its power consumption. In beam acceleration tests, a solenoidal magnetic field set between the laser ion source and the RFQ helped increase both the peak currents before and after the RFQ by a factor of 4

  6. Mosquito cell line C6/36 shows resistence to Cyt1Aa6

    Zhang, L.; Huang, E.; Tang, B.; Guan, X.; Gelbič, Ivan

    2012-01-01

    Roč. 50, č. 4 (2012), s. 265-269 ISSN 0019-5189 R&D Projects: GA MŠk 2B08003 Grant - others:National Nature Science Foundation of China(CN) 31071745; Science Foundation of the Ministry of Education of China(CN) 20093515110010; Science Foundation of the Ministry of Education of China(CN) 20093515120010; Transformation Fund for Agricultural Science and Technology Achievements(CN) 2010GB2C400212; Fujian Colleges and Universities for the Development of the West Strait(CN) 0b08b005 Institutional research plan: CEZ:AV0Z50070508 Keywords : Bacillus thuringiensis * C6/36 cells * indirect immunofluorescence assay Subject RIV: ED - Physiology Impact factor: 1.195, year: 2012 http://nopr.niscair.res.in/bitstream/123456789/13748/1/IJEB%2050(4)%20265-269.pdf

  7. Unilateral hyperplasia of the left posterior arch and associated vertebral schisis at C6 level

    Esposito, Giuseppe; Bonis, Pasquale de; Tamburrini, Gianpiero; Massimi, Luca; Rocco, Concezio di; Byvaltsev, Vadim; Leone, Antonio

    2009-01-01

    We report on a 5-year-old girl with unilateral hyperplasia of the left posterior arch of C6 associated with spina bifida occulta at the same level. Anteroposterior and lateral radiographs of the cervical spine showed hypertrophy of the left lamina as well as overgrowth and elongation of the left spinous process of the sixth cervical vertebra. Computed tomography (CT) examination better depicted this congenital variant and clearly showed the associated schisis of the posterior arch at the same level. Magnetic resonance (MR) imaging examination ruled out other spinal anomalies. The neck pain, the young age of the patient and the local aesthetic abnormality contributed to the surgical indication. To the best of our knowledge, this is the first case in the English literature of unilateral hyperplasia of a posterior cervical arch. Only one previous study has reported a similar congenital anomaly, but it was limited to the left side of the spinous process. (orig.)

  8. Theoretical investigation of the photochemical C2-C6 cyclisation of enyne-heteroallenes.

    Spöler, Carsten; Engels, Bernd

    2003-10-06

    Herein we discuss computations that explain experimental results regarding a highly efficient triplet analogue of the C(2)-C(6) cyclisation of enyne-heteroallenes recently discovered by Schmittel and co-workers.1 To shed some light on the reasons for the differences found between enyne-carbodiimides, enyne-ketenimines and enyne-allenes, we have computed the reaction profiles of the C(2)-C(6) and of the C(2)-C(7) cyclisations for various model compounds, assuming that the reactions take place on the lowest-lying triplet surfaces. Our results nicely explain the differences and the unexpected high efficiency found for the enyne-carbodiimides. The differences between enyne-carbodiimides and enyne-ketenimines prove to be due to differences in the shapes of the corresponding triplet surfaces. In contrast to the enyne-carbodiimides, for which our calculations predict that a direct cyclisation to the biradical intermediates should occur after the vertical excitation, the enyne-ketenimines relax into a local minimum on the triplet surface. As a consequence, further reaction channels are opened. Our computations indicate that enyne-allene compounds do not react because the necessary excitation energy lies outside the range of the employed triplet photosensitizer. Finally, the close agreement between our results and the experimental findings indicates that the underlying reasons for the differences in the photochemical behaviour of enyne-carbodiimides, enyne-ketenimines and enyne-allenes are related to differences in the electronic structures of the parent systems, while substituent effects are less important.

  9. Single-Event Upset and Scaling Trends in New Generation of the Commercial SOI PowerPC Microprocessors

    Irom, Farokh; Farmanesh, Farhad; Kouba, Coy K.

    2006-01-01

    Single-event upset effects from heavy ions are measured for Motorola silicon-on-insulator (SOI) microprocessor with 90 nm feature sizes. The results are compared with previous results for SOI microprocessors with feature sizes of 130 and 180 nm. The cross section of the 90 nm SOI processors is smaller than results for 130 and 180 nm counterparts, but the threshold is about the same. The scaling of the cross section with reduction of feature size and core voltage for SOI microprocessors is discussed.

  10. Antitumor Activity of Rat Mesenchymal Stem Cells during Direct or Indirect Co-Culturing with C6 Glioma Cells.

    Gabashvili, A N; Baklaushev, V P; Grinenko, N F; Mel'nikov, P A; Cherepanov, S A; Levinsky, A B; Chehonin, V P

    2016-02-01

    The tumor-suppressive effect of rat mesenchymal stem cells against low-differentiated rat C6 glioma cells during their direct and indirect co-culturing and during culturing of C6 glioma cells in the medium conditioned by mesenchymal stem cells was studied in an in vitro experiment. The most pronounced antitumor activity of mesenchymal stem cells was observed during direct co-culturing with C6 glioma cells. The number of live C6 glioma cells during indirect co-culturing and during culturing in conditioned medium was slightly higher than during direct co-culturing, but significantly differed from the control (C6 glioma cells cultured in medium conditioned by C6 glioma cells). The cytotoxic effect of medium conditioned by mesenchymal stem cells was not related to medium depletion by glioma cells during their growth. The medium conditioned by other "non-stem" cells (rat astrocytes and fibroblasts) produced no tumor-suppressive effect. Rat mesenchymal stem cells, similar to rat C6 glioma cells express connexin 43, the main astroglial gap junction protein. During co-culturing, mesenchymal stem cells and glioma C6 cells formed functionally active gap junctions. Gap junction blockade with connexon inhibitor carbenoxolone attenuated the antitumor effect observed during direct co-culturing of C6 glioma cells and mesenchymal stem cells to the level produced by conditioned medium. Cell-cell signaling mediated by gap junctions can be a mechanism of the tumor-suppressive effect of mesenchymal stem cells against C6 glioma cells. This phenomenon can be used for the development of new methods of cell therapy for high-grade malignant gliomas.

  11. Structural Stability and Electronic Properties of Na2C6O6 for a Rechargeable Sodium-ion Battery

    Yamashita, Tomoki; Fujii, Akihiro; Momida, Hiroyoshi; Oguchi, Tamio

    2014-03-01

    Sodium-ion batteries have been explored as a promising alternative to lithium-ion batteries owing to a significant advantage of a natural abundance of sodium. Recently, it has been reported that disodium rhodizonate, Na2C6O6, exhibit good electrochemical properties and cycle performance as a minor-metal free organic cathode for sodium-ion batteries. However, its crystal structures during discharge/charge cycle still remain unclear. In this work, we theoretically propose feasible crystal structures of Na2+xC6O6 using first principles calculations. A structural phase transition has been found: Na4C6O6 has a different C6O6 packing arrangement from Na2C6O6. Electronic structures of Na2+xC6O6 during discharge/charge cycle are also discussed. Our predictions could be the key to understanding the discharge/charge process of Na2C6O6. Supported by MEXT program ``Elements Strategy Initiative to Form Core Rersearch Center'' (since 2012), MEXT; Ministry of Education Culture, Sports, Science and Technology, Japan.

  12. Quasi-bound alpha resonant states populated by the 12C(6Li, d) reaction

    Rodrigues, M.R.D.; Borello-Lewin, T.; Miyake, H.; Horodynski-Matsushigue, L.B.; Duarte, J.L.M.; Rodrigues, C.L.; Souza, M.A.; Cunsolo, A.; Cappuzzello, F.; Foti, A.; Agodi, C.; Cavallaro, M.; Ukita, G.M.

    2012-01-01

    Full text: The alpha cluster phenomenon in the light nuclei structure has been the subject of a long time investigation since the proposal of the Ikeda diagrams [1]. The main purpose of the research program in progress is the investigation of this phenomenon in (xα) and (xα+n) nuclei through the ( 6 Li, d) alpha transfer reaction [2-4]. Alpha resonant states around the (4α) threshold in the nucleus 16 O are the focus of the present contribution. In fact, the importance of these resonances at the elements production in stars is recognized, as primarily pointed out by Hoyle in 12 C [6]. The existence of a rotational band with the α + 12 C (Hoyle) cluster state structure was recently demonstrated by Ohkubo and Hirabayashi [6]. In order to explore this region of interest, measurements of the 12 C( 6 Li, d) 16 O reaction up to 17 MeV of excitation at an incident energy of 25.5 MeV, have been performed employing the Sao Paulo Pelletron-Enge Split-Pole facility and the nuclear emulsion detection technique (plates Fuji G6B, 50 μm thick). Spectra associated with six scattering angles, from 5 deg to 29 deg in the laboratory frame, each one 50 cm along the focal surface, were measured. Several narrow resonances with a quasi-bound behavior embedded in the continuum were detected and the resolution of 25 keV allowed for the separation of doublets not resolved before [7,8]. The absolute cross sections and the respective deuteron angular distributions were determined and the analysis is in progress. [1] K. Ikeda et al., Prog. Theor. Phys. Suppl. E 68, 464 (1968); H. Horiuchi, K. Ikeda, and Y. Suzuki, ibid. 44, 225 (1978). [2] M.R.D.Rodrigues et al., in12th International Conference on Nuclear Reaction Mechanism, Varenna, Italy, edited by F. Cerutti and A. Ferrari , CERN Proceedings, 2010-2, pp. 331- 335. [3] T. Borello-Lewin et al., Proceedings of SOTANCP2, Brussels, Belgium 2010, edited by P. Descouvemount et al., Int. J. Mod. Mod. Phys E 20, 1018-1021 (2011). [4] T. Borello

  13. Human ClC-6 is a late endosomal glycoprotein that associates with detergent-resistant lipid domains.

    Sofie Ignoul

    Full Text Available BACKGROUND: The mammalian CLC protein family comprises nine members (ClC-1 to -7 and ClC-Ka, -Kb that function either as plasma membrane chloride channels or as intracellular chloride/proton antiporters, and that sustain a broad spectrum of cellular processes, such as membrane excitability, transepithelial transport, endocytosis and lysosomal degradation. In this study we focus on human ClC-6, which is structurally most related to the late endosomal/lysomal ClC-7. PRINCIPAL FINDINGS: Using a polyclonal affinity-purified antibody directed against a unique epitope in the ClC-6 COOH-terminal tail, we show that human ClC-6, when transfected in COS-1 cells, is N-glycosylated in a region that is evolutionary poorly conserved between mammalian CLC proteins and that is located between the predicted helices K and M. Three asparagine residues (N410, N422 and N432 have been defined by mutagenesis as acceptor sites for N-glycosylation, but only two of the three sites seem to be simultaneously N-glycosylated. In a differentiated human neuroblastoma cell line (SH-SY5Y, endogenous ClC-6 colocalizes with LAMP-1, a late endosomal/lysosomal marker, but not with early/recycling endosomal markers such as EEA-1 and transferrin receptor. In contrast, when transiently expressed in COS-1 or HeLa cells, human ClC-6 mainly overlaps with markers for early/recycling endosomes (transferrin receptor, EEA-1, Rab5, Rab4 and not with late endosomal/lysosomal markers (LAMP-1, Rab7. Analogously, overexpression of human ClC-6 in SH-SY5Y cells also leads to an early/recycling endosomal localization of the exogenously expressed ClC-6 protein. Finally, in transiently transfected COS-1 cells, ClC-6 copurifies with detergent-resistant membrane fractions, suggesting its partitioning in lipid rafts. Mutating a juxtamembrane string of basic amino acids (amino acids 71-75: KKGRR disturbs the association with detergent-resistant membrane fractions and also affects the segregation of ClC-6

  14. Formation of M23C6-type precipitates and chromium-depleted zones in austenite stainless steel

    Kaneko, Kenji; Fukunaga, Tatsuya; Yamada, Kazuhiro; Nakada, Nobuo; Kikuchi, Masao; Saghi, Zineb; Barnard, Jon S.; Midgley, Paul A.

    2011-01-01

    Graphical abstract: Precipitate formation during the in situ annealing experiment at 650 o C. -- Formation of M 23 C 6 carbides and chromium-depleted zones in commercially available type 304L stainless steel were investigated by in situ transmission electron microscopy and analytical transmission electron microscopy. It was found that each individual small M 23 C 6 carbide starts to grow with a clear orientation relationship with the matrix, and film-like carbide was subsequently observed at the interfaces with asymmetric Cr-depleted zones. From these experimental results, a model describing the precipitation of M 23 C 6 and the formation of the Cr-depleted zone was proposed.

  15. 3D organic Na4C6O6/graphene architecture for fast sodium storage with ultralong cycle life.

    Gu, Jianan; Gu, Yue; Yang, Shubin

    2017-11-23

    Sodium-ion batteries (SIBs) have aroused increasing interest as one of the most promising replacements for lithium-ion batteries (LIBs). Here, a novel organic-inorganic 3D Na 4 C 6 O 6 -graphene architecture was successfully fabricated from commercial Na 2 C 6 O 6 and for the first time applied for sodium storage. Hence, the 3D Na 4 C 6 O 6 -graphene architecture exhibits a high reversible capacity, good cyclic performance and high-rate capability for sodium storage.

  16. Mutant breeding of Aspergillus niger irradiated by 12C6+ for hyper citric acid

    Hu Wei; Li Wenjian; Chen Jihong; Liu Jing; Wang Shuyang; Wang Jufang; Lu Dong

    2014-01-01

    In this study, strains of Aspergillus niger No.4 for hyper citric acid were irradiated to different doses by 80 MeV/u 12 C 6+ ion beams. Seven mutant strains showed marked citric acid over-production records and faster productivity than initial Aspergillus niger No.4 by shaking flash fermentation. The maximum product yield was 132.8 gL -1 (the H4002 strain) being a 8.8% increase to the initial strain. The scale-up experiment was carried out in a 100 L bioreactor. The mutant H4002 can accumulate 187gL -1 product yield of citric acid from starch liquefying supernatant. The productivity of citric acid was 2.75 g L -1 h -1 . So, the mutant H4002 possesses rapid sugar katabolism for producing citric acid. Meanwhile, the pellet morphology kept compact and round during the whole submerged fermentation, which was suited to produce citric acid. The results indicate that mutant H4002 has potential ability to produce citric acid rapidly. (authors)

  17. Evaluation of the MODIS C6 Aerosol Optical Depth Products over Chongqing, China

    Guangming Shi

    2017-11-01

    Full Text Available The Moderate Resolution Imaging Spectroradiometer (MODIS Collection 6 (C6 aerosol optical depth (AOD products from the 10/3 km Dark Target (DT and Deep Blue (DB algorithms are firstly evaluated using ground observed AODs by the sun photometer in Chongqing, a mountainous mega-city in southwest China. The validation results show that MODIS AODs from 10/3 km DT algorithm are comparable with those of the sun photometer, although there are slight overestimations. However, the DB algorithm substantially underestimates MODIS AODs when comparing with those of the sun photometer. Error analyses imply that the bias of surface reflectance estimation is the main error source for both algorithms. The cloud screening scheme of the DT algorithm is more effective than the DB algorithm. The cloud vicinity effect should be considered in the quality control processes for both of the algorithms. A sensitivity test suggests that in complex terrain area, like Chongqing, the collocation method in the validation of satellite products should be carefully selected according to local circumstances. When comparing the monthly mean AODs of MODIS products with sun photometer observations, it shows that the Terra MODIS AOD products are valid to represent the mean statuses in summer and autumn, but the monthly mean of Aqua MODIS AODs are limited in Chongqing.

  18. Kinetics of M23C6 carbide growth in Type 316 stainless steel

    Skyrme, G.; Norbury, J.

    1980-11-01

    A mathematical model has been developed which describes the kinetics of the reduction in the dissolved carbon concentration in austenitic steels due to the precipitation of M 23 C 6 . It is assumed that carbon and chromium diffuse simultaneously and independently to carbide nucleation sites, and that at the carbide/matrix interface (a) the ratio of the fluxes of carbon and chromium is constant, and (b) the elements are in thermodynamic equilibrium. Two types of nucleation site have been considered, (a) at grain boundaries and (b) as isolated particles throughout the grains. Since the diffusion coefficient of carbon is several orders of magnitude greater than that of chromium, the carbon is shown to respond relatively rapidly to concentration changes and this fact has facilitated the formulation of approximate solutions to the equations. It is shown that the rate controlling process is the diffusion of chromium to the carbide site. The resultant equations are compared with available published data on carbide precipitation. Good agreement is found between the models and experimental observations. (U.K.)

  19. Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability.

    Jacobsson, S O; Rongård, E; Stridh, M; Tiger, G; Fowler, C J

    2000-12-15

    In the present study, the effects of the combination of tamoxifen ((Z)-2[p-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylamine citrate) and three cannabinoids (Delta(9)-tetrahydrocannabinol [Delta(9)-THC], cannabidiol, and anandamide [AEA]) upon the viability of C6 rat glioma cells was assessed at different incubation times and using different culturing concentrations of foetal bovine serum (FBS). Consistent with previous data for human glioblastoma cells, the tamoxifen sensitivity of the cells was increased as the FBS content of the culture medium was reduced from 10 to 0.4 and 0%. The cells expressed protein kinase C alpha and calmodulin (the concentration of which did not change significantly as the FBS concentration was reduced), but did not express estrogen receptors. Delta(9)-THC and cannabidiol, but not AEA, produced a modest reduction in cell viability after 6 days of incubation in serum-free medium, whereas no effects were seen in 10% FBS-containing medium. There was no observed synergy between the effects of tamoxifen and the cannabinoids upon cell viability.

  20. Modeling the degradation mechanisms of C6/LiFePO4 batteries

    Li, Dongjiang; Danilov, Dmitri L.; Zwikirsch, Barbara; Fichtner, Maximilian; Yang, Yong; Eichel, Rüdiger-A.; Notten, Peter H. L.

    2018-01-01

    A fundamental electrochemical model is developed, describing the capacity fade of C6/LiFePO4 batteries as a function of calendar time and cycling conditions. At moderate temperatures the capacity losses are mainly attributed to Li immobilization in Solid-Electrolyte-Interface (SEI) layers at the anode surface. The SEI formation model presumes the availability of an outer and inner SEI layers. Electron tunneling through the inner SEI layer is regarded as the rate-determining step. The model also includes high temperature degradation. At elevated temperatures, iron dissolution from the positive electrode and the subsequent metal sedimentation on the negative electrode influence the capacity loss. The SEI formation on the metal-covered graphite surface is faster than the conventional SEI formation. The model predicts that capacity fade during storage is lower than during cycling due to the generation of SEI cracks induced by the volumetric changes during (dis)charging. The model has been validated by cycling and calendar aging experiments and shows that the capacity loss during storage depends on the storage time, the State-of-Charge (SoC), and temperature. The capacity losses during cycling depend on the cycling current, cycling time, temperature and cycle number. All these dependencies can be explained by the single model presented in this paper.

  1. Comparative study of the catalytic activity of the complexes Cp*RuCl(PAr3)2 [Ar = -C6H5 and 4-CF3-C6H4] in the ATRP of styrene

    Villa-Hernandez, Alejandro M.; Rosales-Velazquez, Claudia P.; Torres-Lubian, Jose R.; Saldivar-Guerra, Enrique

    2011-01-01

    Styrene polymerization by ATRP was conducted independently using the complexes Cp * RuCl(PPh 3 ) 2 , and Cp * RuCl[P(4-CF 3 -C 6 H 4 ) 3 ] 2 as catalysts, in order to evaluate the influence of the electronic properties of the phosphine ligands on the rate and control of the polymerization. The kinetic data for polymerizations carried out with Cp * RuCl(PPh 3 ) 2 , show that molecular weights increase linearly with conversion with an average initiation efficiency of 0.77. The molecular weights obtained in the kinetic study with Cp * RuCl[P(4-CF 3 -C 6 H 4 ) 3 ] 2 also increase with conversion but show a marked deviation below the theoretical molecular weights. This behavior was explained by the gradual, irreversible, oxidation of catalyst Cp * RuCl[P(4-CF 3 -C 6 H 4 ) 3 ] 2 as confirmed by 31 P-NMR spectroscopy. Catalyst Cp * RuCl(PPh 3 ) 2 promotes the polymerization with a rate of polymerization higher than that obtained using Cp * RuCl[P(4-CF 3 -C 6 H 4 ) 3 ] 2 ; this is consistent with the better electron donating properties of PPh 3 versus P(4-CF 3 -C 6 H 4 ) 3 . Preliminary studies of styrene polymerization by ATRP in supercritical CO 2 , shows that only catalyst Cp * RuCl[P(4-CF 3 -C 6 H 4 ) 3 ] 2 , with fluorinated ligands, was active. (author)

  2. 15 CFR 744.17 - Restrictions on certain exports and reexports of general purpose microprocessors for “military...

    2010-01-01

    ... reexports of general purpose microprocessors for âmilitary end-usesâ and to âmilitary end-users.â 744.17...: END-USER AND END-USE BASED § 744.17 Restrictions on certain exports and reexports of general purpose microprocessors for “military end-uses” and to “military end-users.” (a) General prohibition. In addition to the...

  3. Tests of microprocessor-based relay protection devices: Problems and solutions

    Gurevich Vladimir

    2009-01-01

    Full Text Available Usually, the operational condition of relay protection devices is checked with specific settings used for the relay operation in a certain network point. In the author's opinion in order to verify the proper operation of complex multifunctional microprocessor-based protection devices (MPD at their inspection, start-up after repairs or during periodic tests there is no need to use the actual settings at which the relay is to be operated in a certain network's point. It should be tested for proper operation at several of its most critical preset characteristic points as well as in several preset characteristics constituting its most complicated (combined operation modes, including the dynamic operation modes with preset transition processes specific for standard power networks (not necessarily for a specific point. The proposed set of actions for the unification of software platforms of the modern, microprocessor-based relay protection test systems will enable examination of modern MPD in an absolutely new way. .

  4. Failure analysis on false call probe pins of microprocessor test equipment

    Tang, L. W.; Ong, N. R.; Mohamad, I. S. B.; Alcain, J. B.; Retnasamy, V.

    2017-09-01

    A study has been conducted to investigate failure analysis on probe pins of test modules for microprocessor. The `health condition' of the probe pin is determined by the resistance value. A test module of 5V power supplied from Arduino UNO with "Four-wire Ohm measurement" method is implemented in this study to measure the resistance of the probe pins of a microprocessor. The probe pins from a scrapped computer motherboard is used as the test sample in this study. The functionality of the test module was validated with the pre-measurement experiment via VEE Pro software. Lastly, the experimental work have demonstrated that the implemented test module have the capability to identify the probe pin's `health condition' based on the measured resistance value.

  5. The use of microprocessors at TRIUMF in the control of radiation safety interlock systems

    King, L.

    1988-01-01

    At TRIUMF the cyclotron vault, all primary beam lines, and each experimental area has a dedicated control unit to manage the safety interlock control of the area lockup sequence, beam blocker drive and area access. Typically each area has 24 devices which are monitored to control 16 outputs. These control units (Area Safety Units) were first implemented through the use of relay logic. The relay logic was reliable but difficult to modify to incorporate changes to the areas. In 1979 it was decided to use microprocessors in the form of single board computers to control the Area Safety Units. The details of the hardware and software is discussed as well as the advantages of microprocessor control

  6. Sub-50 nm gate length SOI transistor development for high performance microprocessors

    Horstmann, M.; Greenlaw, D.; Feudel, Th.; Wei, A.; Frohberg, K.; Burbach, G.; Gerhardt, M.; Lenski, M.; Stephan, R.; Wieczorek, K.; Schaller, M.; Hohage, J.; Ruelke, H.; Klais, J.; Huebler, P.; Luning, S.; Bentum, R. van; Grasshoff, G.; Schwan, C.; Cheek, J.; Buller, J.; Krishnan, S.; Raab, M.; Kepler, N.

    2004-01-01

    Partial depleted (PD) SOI technologies have reached maturity for production of high speed, low power microprocessors. The paper will highlight several challenges found during the course of development for bringing 40 nm gate length (L GATE ) PD SOI transistors into volume manufacturing for high-speed microprocessors. The key innovations developed for this transistor in order to overcome classical gate oxide and L GATE scaling is an unique differential triple spacer structure, stressed overlayer films inducing strain in the Silicon channel and optimized junctions. This transistor structure yields an outstanding ring oscillator speed with an unloaded inverter delay of 5.5 ps. The found improvements are highly manufacturable and scaleable for future device technologies like FD SOI

  7. A measurement of cosmic-ray LET-spectra using a microprocessor supported microscope

    Beer, J.; Heinrich, W.

    1982-01-01

    A microprocessor supported semi-automatic system for measurements of nuclear tracks in plastic detectors is presented. It consists of a microscope and a stepping motor driven stage. A Motorola microprocessor MC 6800 controls the measurement. It accepts the co-ordinates of the stage as well as the position of the focus and computes cone length and dip angle from the three-dimensional co-ordinates. LET-spectra were measured from two cellulose nitrate foils of the Biostack III experiment flown with the Apollo-Soyus-Test-Project in 1975. One of these foils was shielded by 3 g/cm 2 and the other one by 15 g/cm 2 . The two spectra show no statistically significant decrease of intensity. (author)

  8. Emulation of MS DOS Operational System on the Autonomous Crate-Controller with I8086 microprocessor

    Hons, Z.; Cizek, P.; Streit, V.

    1988-01-01

    KM-DOS operating system for CAMAC autonomous crate-controller based on Intel 8086/8087 microprocessor connected with Pravec-16 IBM PC is described. The KM-DOS system fully emulates the MS DOS environment on the CAMAC controller. Thus ASSEMBLER, FORTRAN, C and PASCAL programs compiled and linked on IBM PC and compatible can be run on the CAMAC controller and parall work of both computers is enabled

  9. Microprocessor-controlled inhalation system for repeated exposure of animals to aerosols

    Carpenter, R.L.; Barr, F.P.; Leydig, R.L.; Rajala, R.E.

    1979-01-01

    A microprocessor-controlled inhalation exposure system (MCIES) has been built to automate aerosol generation and sampling while controlling exposure time for animal toxicity studies. The system has a time resolution of 0.1 s and automatically sequences the exposure events from initiation to temination of the exposure. The operator is required to preset all airflows, read in a paper tape containing the time sequence of events, and initiate the automatic sequence by closing a switch

  10. Front end embedded microprocessors in the JET computer-based control system, past, present and future

    Steed, C.A.; VanderBeken, H.; Browne, M.L.; Fullard, K.; Reed, K.; Tilley, M.; Schmidt, V.

    1987-01-01

    A brief history of the use of Front End Microprocessors in the JET Control and Data Acquisition System (CODAS) is presented. The present expansion in their use from 2 or 3 in 1983 to 27 now, is covered along with the reasoning behind their present usage. Finally, their future planned use in the area of remote handling is discussed and the authors present views on the use of front end processing in future large distributed control systems are presented

  11. Use of a Microprocessor to Implement an ADCCP Protocol (Federal Standard 1003).

    1980-07-01

    results of other studies, to evaluate the operational and economic impact of incorporating various options in Federal Standard 1003. The effort...the LSI interface and the microprocessor; the LSI chip deposits bytes in its buffer as the producer, and the MPU reads this data as the consumer...on the interface between the MPU and the LSI protocol chip. This requires two main processes to be running at the same time--transmit and receive. The

  12. MONICA - a programmable microprocessor for track recognition in an e+e- experiment at PETRA

    Schildt, P.; Stuckenberg, H.J.; Wermes, N.

    1981-01-01

    The microprocessor device MONICA is used in the TASSO experiment at PETRA. Its task is to reconstruct events in the cylindrical driftchamber on-line. Used as an event filter MONICA provides a 2 prong trigger without any further requirements. The speed of the processor (event reconstruction times must be in the order of 1 ms) is achieved by a 4 x 4 bit slice processor in ECL technology, content addressable memories and table look up. The track finding efficiency is 80%. (orig.)

  13. A fail-safe microprocessor-based protection system utilising low-level multiplexed sensor signals

    Orme, S.; Evans, N.J.; Wey, B.O.

    1985-01-01

    The paper describes a fail-safe reactor protection system, called the individual sub-assembly temperature monitoring system (ISAT). It is being developed for the commercial demonstration fast reactor. The system incorporates recent advances in solid-state electronics and in particular microprocessors to implement time-shared data acquisition techniques to obtain and process data from around 1400 fast response thermocouples whilst meeting the required levels for reliability and availability. (author)

  14. API testing program - calibration of microprocessor based flowmeters for integrated metering systems

    Elliot, Kenneth D. [Omni Flow Computers, Inc., Stafford, TX (United States)

    2005-07-01

    Microprocessor based flowmeter technologies for liquids, such as Coriolis mass meters, and Ultrasonic flowmeters hold great promise. These technologies offer many advantages, such as no rotating parts, self-diagnostic checks, which can help anticipate and warn of impending failures before they have a major impact on the measurement. These meters are substantially different though than other primary devices due to their heavy reliance on the accompanying secondary electronics. One method to prove that they are accurate would be proving the flowmeter, using a pipe prover or small volume prover (SVP), but these proving methods are designed to count 'real time' pulses from a turbine or PD meter between a known volume, they are not designed to count 'time delayed' 'manufactured pulses' from a microprocessor. There are limitations of the manufactured pulse train and it affects the ability of the flowmeter to be proved using current proving technology. The author of this paper, a chairman of an American Petroleum Institute working group, investigated how the 'microprocessor generated pulses' produced by these types of flowmeters, interacted with the existing measurement technologies in use today. Several microprocessor based flowmeter technologies have been tested, including; Ultrasonic, Coriolis, and Helical Turbine with pulse multiplying preamplifier. Wherever possible, flowmeters of various sizes, and from several vendors have been tested. A significant amount of data has been collected which sheds light into why these types of flowmeters are sometimes difficult to prove. This paper describes the API testing program, and the methodology behind it. It presents results and findings, and offers specific recommendations that may eventually be incorporated into API documents and/or standards in the future. (author)

  15. A microprocessor-controlled assay for the estimation of human placental lactogen

    Adam, T.; Roulston, J.E.; Bagshawe, K.D.

    1979-01-01

    A radioimmunoassay for human placental lactogen (HPL) is described using the KEMTEK 3000, which is a modular radioimmunoassay apparatus controlled by a microprocessor. Operation of the KEMTEK 3000 is largely automatic and it requires minimal intervention from the operator. It is capable of 300 reactions per hour so that a large number of estimations can readily be performed. HPL was assayed by a double antibody method on serum samples from pregnant women and patients with trophoblastic tumours. (Auth.)

  16. Autonomous controller (JCAM 10) for CAMAC crate with 8080 (INTEL) microprocessor

    Gallice, P.; Mathis, M.

    1975-01-01

    The CAMAC crate autonomous controller JCAM-10 is designed around an INTEL 8080 microprocessor in association with a 5K RAM and 4K REPROM memory. The concept of the module is described, in which data transfers between CAMAC modules and the memory are optimised from software point of view as well as from execution time. In fact, the JCAM-10 is a microcomputer with a set of 1000 peripheral units represented by the CAMAC modules commercially available

  17. AFRRI's conversion to a microprocessor-based reactor instrumentation and control system

    Moore, Mark L.; Hodgdon, Kenneth M.

    1986-01-01

    The Armed Forces Radiobiology Research Institute (AFRRI) is procuring a state-of- the-art microprocessor-based instrumentation and control system to operate AFRRI's 1 MW (steady-state), 3000 MW (pulse) TRIGA Mark-F reactor. This system will replace the current control console while improving or maintaining the existing operational capabilities and safety characteristics. The new unit will have a 15-year design life using state-of-the-art components

  18. Software support for Motorola 68000 microprocessor at CERN. M68MIL cross macro assembler

    Eicken, H. von.

    1983-01-01

    This document is a user's guide for programming the Motorola 68000 microprocessor in assembly language. It describes the programming model, addressing modes and instruction set of the M 68000 as well as the use of the M68mil cross macro assembler. Version 3.6 of the assembler has been installed at CERN on CDC, DEC VAX, IBM, Norsk Data and Siemens computers. The source code of the assembler is available from CERN on request. (orig.)

  19. A monitoring and protective system for mine hoists using a microprocessor

    Jianlin, Zhu

    1981-11-01

    In view of the existing problems of depth indicators and tachometers currently used in mine hoists, a measuring technique using a 'wire cable magnetic stripe' and a tentative proposal for a monitoring system with a microprocessor are described. The system can be used for measuring and indicating the depth, speed of the hoisting system, and can provide protection against overwinding, overspeeding and slack rope as well as monitoring the direction of hoisting. (In Chinese)

  20. INVESTIGATION OF MICROPROCESSOR CURRENT PROTECTION LINES WITH IMPROVED INDICES OF TECHNICAL PERFECTION

    E. V. Buloichyk

    2014-01-01

    Full Text Available Technical perfection improvement of microprocessor current protection of distribution networks lines is provided by introduction of asymmetrical fault mode determination and fault location functions in the algorithm of its functioning. As a result of computing experiment the basic indices of the technical perfection of current protection have been obtained in the paper. The paper proves high efficiency of the proposed methods that ensure selective and proper operation in the different modes of the controlled line.

  1. Data acquisition and processing system of energy dispersive X-ray spectrometer with microprocessor

    Horkay, G.; Kis-Varga, M.; Lakatos, T.; Molnar, J.; Zsurzs, M.

    1984-01-01

    For quantitative analysis of chemical elements by the method of X-ray spectroscopy a multichannel analyzer on the base of minicomputer with the INTEL 8080 A microprocessor is developed. The data acquisition and data processing systems which comprise a central processor, memory unit, ADC and display are described. Major system subprograms are enumerated. An example of Pb concentration determinating in a bronze specimen is given

  2. Multichannel analyzer with real-time correction of counting losses based on a fast 16/32 bit microprocessor

    Westphal, G.P.; Kasa, T.

    1984-01-01

    It is demonstrated that from a modern microprocessor with 32 bit architecture and from standard VLSI peripheral chips a multichannel analyzer with real-time correction of counting losses may be designed in a very flexible yet cost-effective manner. Throughput rates of 100,000 events/second are a good match even for high-rate spectroscopy systems and may be further enhanced by the use of already available CPU chips with higher clock frequency. Low power consumption and a very compact form factor make the design highly recommendable for portable applications. By means of a simple and easily reproducible rotating sample device the dynamic response of the VPG counting loss correction method have been tested and found to be more than sufficient for conceivable real-time applications. Enhanced statistical accuracy of correction factors may be traded against speed of response by the mere change of one preset value which lends itself to the simple implementation of self-adapting systems. Reliability as well as user convenience is improved by self-calibration of pulse evolution time in the VPG counting loss correction unit

  3. Thyristor voltage converter in induction electric drives with microprocessor control

    Braslavsky, I.; Zuzev, A.; Shilin, S. [Electric Drive Department, Urals State Technical University, Ekaterinburg (Russian Federation)

    1997-12-31

    The paper consists of some results on developed pulse model of thyristor voltage converter which is one of the most mathematically complicated unit of electric drive. The model structure and model parameter calculating method are represented. The application of the model allows to analyse stability in `locally` by the linear pulse system theory methods with talking into consideration quantise processes within the converter. Such application provides the obtaining higher accurate results comparing with the non-linear system theory approximate methods. Logarithmic frequency characteristics are used to analyse converter dynamic features and they are represented too. (orig.) 4 refs.

  4. A lightweight security scheme for wireless body area networks: design, energy evaluation and proposed microprocessor design.

    Selimis, Georgios; Huang, Li; Massé, Fabien; Tsekoura, Ioanna; Ashouei, Maryam; Catthoor, Francky; Huisken, Jos; Stuyt, Jan; Dolmans, Guido; Penders, Julien; De Groot, Harmke

    2011-10-01

    In order for wireless body area networks to meet widespread adoption, a number of security implications must be explored to promote and maintain fundamental medical ethical principles and social expectations. As a result, integration of security functionality to sensor nodes is required. Integrating security functionality to a wireless sensor node increases the size of the stored software program in program memory, the required time that the sensor's microprocessor needs to process the data and the wireless network traffic which is exchanged among sensors. This security overhead has dominant impact on the energy dissipation which is strongly related to the lifetime of the sensor, a critical aspect in wireless sensor network (WSN) technology. Strict definition of the security functionality, complete hardware model (microprocessor and radio), WBAN topology and the structure of the medium access control (MAC) frame are required for an accurate estimation of the energy that security introduces into the WBAN. In this work, we define a lightweight security scheme for WBAN, we estimate the additional energy consumption that the security scheme introduces to WBAN based on commercial available off-the-shelf hardware components (microprocessor and radio), the network topology and the MAC frame. Furthermore, we propose a new microcontroller design in order to reduce the energy consumption of the system. Experimental results and comparisons with other works are given.

  5. Microprocessor Activity Controls Differential miRNA Biogenesis In Vivo

    Thomas Conrad

    2014-10-01

    Full Text Available In miRNA biogenesis, pri-miRNA transcripts are converted into pre-miRNA hairpins. The in vivo properties of this process remain enigmatic. Here, we determine in vivo transcriptome-wide pri-miRNA processing using next-generation sequencing of chromatin-associated pri-miRNAs. We identify a distinctive Microprocessor signature in the transcriptome profile from which efficiency of the endogenous processing event can be accurately quantified. This analysis reveals differential susceptibility to Microprocessor cleavage as a key regulatory step in miRNA biogenesis. Processing is highly variable among pri-miRNAs and a better predictor of miRNA abundance than primary transcription itself. Processing is also largely stable across three cell lines, suggesting a major contribution of sequence determinants. On the basis of differential processing efficiencies, we define functionality for short sequence features adjacent to the pre-miRNA hairpin. In conclusion, we identify Microprocessor as the main hub for diversified miRNA output and suggest a role for uncoupling miRNA biogenesis from host gene expression.

  6. The bit slice micro-processor 'GESPRO' as a project in the UA2 experiment

    Becam, C; Delanghe, J; Fest, H M; Lecoq, J; Martin, H; Mencik, M; MerkeI, B; Meyer, J M; Perrin, M; Plothow, H; Rampazzo, J P; Schittly, A

    1981-01-01

    The bit slice micro-processor GESPRO is a CAMAC module plugged into a standard Elliot system crate via which it communicates as a slave with its host computer. It has full control of CAMAC as a master unit. GESPRO is a 24 bit machine with multi-mode memory addressing capacity of 64K words. The micro-processor structure uses 5 buses including pipe-line registers to mask access time and 16 interrupt levels. The micro-program memory capacity is 2K (RAM) words of 48 bits each. A special hardwired module allows floating point, as well as integer, multiplication of 24*24 bits, result in 48 bits, in about 200 ns. This micro-processor could be used in the UA2 data acquisition chain and trigger system for the following tasks: (a) online data reduction, i.e. to read DURANDAL, process the information resulting in accepting or rejecting the event; (b) readout and analysis of the accepted data; (c) preprocess the data. The UA2 version of GESPRO is under construction, programs and micro-programs are under development. Hard...

  7. The bit slice micro-processor 'GESPRO' as a project in the UA2 experiment

    Becam, C.; Bernaudin, P.; Delanghe, J.; Mencik, M.; Merkel, B.; Plothow, H.; Fest, H.M.; Lecoq, J.; Martin, H.; Meyer, J.M.

    1981-01-01

    The bit slice micro-processor GESPRO, as it is proposed for use in the UA 2 data acquisition chain and trigger system, is a CAMAC module plugged into a standard Elliott System crate via which it communicates as a slave with its host computer (ND, DEC). It has full control of CAMAC as a master unit. GESPRO is a 24 bit machine (150 ns effective cycle time) with multi-mode memory addressing capacity of 64 K words. The micro-processor structure uses 5 busses including pipe-line registers to mask access time and 16 interrupt levels. The micro-program memory capacity is 2 K (RAM) words of 48 bits each. A special hardwired module allows floating point (as well as integer) multiplication of 24 x 24 bits, result in 48 bits, in about 200 ns. This micro-processor could be used in the UA2 data acquisition chain and trigger system for the following tasks: a) online data reduction, i.e. to read DURANDAL (fast ADC's = the hardware trigger in the experiment), process the information (effective mass calculation, etc.) resulting in accepting or rejecting the event. b) read out and analysis of the accepted data (collect statistical information). c) preprocess the data (calculation of pointers, address decoding, etc.). The UA2 version of GESPRO is under construction, programs and micro-programs are under development. Hardware and software will be tested with simulated data. First results are expected in about one year from now. (orig.)

  8. Designs and performance of three new microprocessor-controlled knee joints.

    Thiele, Julius; Schöllig, Christina; Bellmann, Malte; Kraft, Marc

    2018-02-09

    A crossover design study with a small group of subjects was used to evaluate the performance of three microprocessor-controlled exoprosthetic knee joints (MPKs): C-Leg 4, Plié 3 and Rheo Knee 3. Given that the mechanical designs and control algorithms of the joints determine the user outcome, the influence of these inherent differences on the functional characteristics was investigated in this study. The knee joints were evaluated during level-ground walking at different velocities in a motion analysis laboratory. Additionally, technical analyses using patents, technical documentations and X-ray computed tomography (CT) for each knee joint were performed. The technical analyses showed that only C-Leg 4 and Rheo Knee 3 allow microprocessor-controlled adaptation of the joint resistances for different gait velocities. Furthermore, Plié 3 is not able to provide stance extension damping. The biomechanical results showed that only if a knee joint adapts flexion and extension resistances by the microprocessor all known advantages of MPKs can become apparent. But not all users may benefit from the examined functions: e.g. a good accommodation to fast walking speeds or comfortable stance phase flexion. Hence, a detailed comparison of user demands and performance of the designated knee joint is mandatory to ensure a maximum in user outcome.

  9. Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs

    Victoria A. Church

    2017-09-01

    Full Text Available The cellular abundance of mature microRNAs (miRNAs is dictated by the efficiency of nuclear processing of primary miRNA transcripts (pri-miRNAs into pre-miRNA intermediates. The Microprocessor complex of Drosha and DGCR8 carries this out, but it has been unclear what controls Microprocessor’s differential processing of various pri-miRNAs. Here, we show that Drosophila DGCR8 (Pasha directly associates with the C-terminal domain of the RNA polymerase II elongation complex when it is phosphorylated by the Cdk9 kinase (pTEFb. When association is blocked by loss of Cdk9 activity, a global change in pri-miRNA processing is detected. Processing of pri-miRNAs with a UGU sequence motif in their apical junction domain increases, while processing of pri-miRNAs lacking this motif decreases. Therefore, phosphorylation of RNA polymerase II recruits Microprocessor for co-transcriptional processing of non-UGU pri-miRNAs that would otherwise be poorly processed. In contrast, UGU-positive pri-miRNAs are robustly processed by Microprocessor independent of RNA polymerase association.

  10. An Asynchronous Circuit Design Technique for a Flexible 8-Bit Microprocessor

    Karaki, Nobuo; Nanmoto, Takashi; Inoue, Satoshi

    This paper presents an asynchronous design technique, an enabler for the emerging technology of flexible microelectronics that feature low-temperature processed polysilicon (LTPS) thin-film transistors (TFT) and surface-free technology by laser annealing/ablation (SUFTLA®). The first design instance chosen is an 8-bit microprocessor. LTPS TFTs are good for realizing displays having integrated VLSI circuit at lower costs. However, LTPS TFTs have drawbacks, including substantial deviations in characteristics and the self-heating phenomenon. To solve these problems, the authors adopted the asynchronous circuit design technique and developed an asynchronous design language called Verilog+, which is based on a subset of Verilog HDL® and includes minimal primitives used for describing the communications between modules, and the dedicated tools including a translator called xlator and a synthesizer called ctrlsyn. The flexible 8-bit microprocessor stably operates at 500kHz, drawing 180μA from a 5V power source. The microprocessor's electromagnetic emissions are 21dB less than those of the synchronous counterpart.

  11. Chromosomal aberrations induced by 12C6+ ions and 6Co γ-rays in mouse immature oocytes

    Zhang Hong; Duan Xin; Yuan Zhigang; Li Wenjian; Zhou Guangming; Zhou Qingming; Bing Liu; Min Fengling; Li Xiaoda; Xie Yi

    2006-01-01

    The ovaries of Kun-Ming strain mice (3 weeks) were irradiated with different doses of 12 C 6+ ion or 6 Co γ-ray. Chromosomal aberrations were analyzed in metaphase II oocytes at 7 weeks after irradiation. The relative biological effectiveness (RBE) of 12 C 6+ ion was calculated with respect to 6 Co γ-ray for the induction of chromosomal aberrations. The 12 C 6+ ion and 6 Co γ-ray dose-response relationships for chromosomal aberrations were plotted by linear quadratic models. The data showed that there was a dose-related increase in frequency of chromosomal aberrations in all the treated groups compared to controls. The RBE values for 12 C 6+ ions relative to 6 Co γ-rays were 2.49, 2.29, 1.57, 1.42 or 1.32 for the doses of 0.5, 1.0, 2.0, 4.0 or 6.0 Gy, respectively. Moreover, a different distribution of the various types of aberrations has been found for 12 C 6+ ion and 6 Co γ-ray irradiations. The dose-response relationships for 12 C 6+ ion and 6 Co γ-ray exhibited positive correlations. The results from the present study may be helpful for assessing genetic damage following exposure of immature oocytes to ionizing radiation

  12. Network Interface Specification for the T1 Microprocessor

    1994-05-01

    details of the data transfer functional units, interconnect structure, and network operation. Application Layer Communication Model Communication...use of the communication resources. 3.6 Network Virtualisation The CNS-1 is designed for single-user, batch-style processing; no timesharing or space...matches the count register (both the timer and count register are in the network interface and are user-accessible). Although this function is not strictly

  13. A microprocessor from AVR to embedded SoC

    Jeong, Geum Seoh

    2005-01-01

    This book was divided into two parts. The first part consists of ten chapter, which are basic knowledge, code vision AVR compiler, analysis on code vision, introduction and characteristic of AVR, I/O ports, interrupt and timer/counter, LCD, serial communication, analog comparator and stepping Motor and digital control of DC Motor. In the second part, it introduces Embedded Soc including application field, its characteristic, general description, functional description, designs with Quartus II.

  14. Antitenascin antibody 81C6 armed with {sup 177}Lu: in vivo comparison of macrocyclic and acyclic ligands

    Yordanov, Alexander T. [Department of Radiology, Duke University Medical Center Durham, NC 27710 (United States); Hens, Marc [Department of Radiology, Duke University Medical Center Durham, NC 27710 (United States); Pegram, Charles [Department of Pathology, Duke University Medical Center Durham, NC 27710 (United States); Bigner, Darell D. [Department of Pathology, Duke University Medical Center Durham, NC 27710 (United States); Zalutsky, Michael R. [Department of Radiology, Duke University Medical Center Durham, NC 27710 (United States)]. E-mail: zalut001@mc.duke.edu

    2007-02-15

    Introduction: When labeled with iodine-131, the antitenascin monoclonal antibody (mAb) 81C6 has shown promise as a targeted radiotherapeutic in patients with brain tumors. Because of its more favorable {gamma}-ray properties, lutetium-177 might be a better low-energy {beta}-emitter for this type of therapy. Materials and Methods: Chimeric 81C6 (ch81C6) was labeled with {sup 177}Lu using the acyclic 1B4M ligand and the macrocyclic ligands NHS-DOTA and MeO-DOTA and evaluated for binding to tenascin. Three paired-label tissue distribution experiments were performed in normal mice receiving one of the {sup 177}Lu-labeled immunoconjugates plus {sup 125}I-labeled ch81C6 labeled using Iodogen. Paired-label experiments in athymic mice bearing subcutaneous D54 MG human glioma xenografts were done to directly compare the biodistribution of ch81C6-1B4M-{sup 177}Lu and {sup 125}I-labeled ch81C6, and ch81C6-MeO-DOTA-{sup 177}Lu and {sup 125}I-labeled ch81C6. Similar comparisons were done using murine (mu) instead of ch81C6. The primary parameter utilized for evaluation was the {sup 177}Lu/{sup 125}I uptake ratio in each tissue. Results: In the studies performed in normal mice, the NHS-DOTA ligand yielded the highest {sup 177}Lu/{sup 125}I uptake ratios in tissues indicative of loss of label from the chelate; for this reason, only 1B4M and MeO-DOTA were evaluated further. The {sup 177}Lu/{sup 125}I ratio in bone increased gradually with time for the chimeric conjugates; however, there were no significant differences between ch81C6-1B4M-DTPA-{sup 177}Lu and ch81C6-MeO-DOTA-{sup 177}Lu. In contrast, mu81C6-1B4M-DTPA-{sup 177}Lu and mu81C6-MeO-DOTA-{sup 177}Lu showed a more dramatic increase in the {sup 177}Lu/{sup 125}I ratio in bone - from 2.4{+-}0.3 and 1.7{+-}0.2 at Day 1 to 8.5{+-}1.1 and 4.2{+-}0.5 at Day 7, respectively. Conclusion: With these antitenascin constructs, the nature of the mAb had a profound influence on the relative degree of loss of {sup 177}Lu from these

  15. NESS038C6, a novel selective CB1 antagonist agent with anti-obesity activity and improved molecular profile.

    Mastinu, Andrea; Pira, Marilena; Pani, Luca; Pinna, Gérard Aimè; Lazzari, Paolo

    2012-10-01

    The present work aims to study the effects induced by a chronic treatment with a novel CB1 antagonist (NESS038C6) in C57BL/6N diet-induced obesity (DIO) mice. Mice treated with NESS038C6 and fed with a fat diet (NESS038C6 FD) were compared with the following three reference experimental groups: DIO mice fed with the same fat diet used for NESS038C6 and treated with vehicle or the reference CB1 antagonist/inverse agonist rimonabant, "VH FD" and "SR141716 FD", respectively; DIO mice treated with vehicle and switched to a normal diet (VH ND). NESS038C6 chronic treatment (30 mg/kg/day for 31 days) determined a significant reduction in DIO mice weight relative to that of VH FD. The entity of the effect was comparable to that detected in both SR141716 FD and VH ND groups. Moreover, if compared to VH FD, NESS038C6 FD evidenced: (i) improvement of cardiovascular risk factors; (ii) significant decrease in adipose tissue leptin expression; (iii) increase in mRNA expression of hypothalamic orexigenic peptides and a decrease of anorexigenic peptides; (iv) expression increase of metabolic enzymes and peroxisome proliferator-activated receptor-α in the liver; (v) normalization of monoaminergic transporters and neurotrophic expression in mesolimbic area. However, in contrast to the case of rimonabant, the novel CB1 antagonist improved the disrupted expression profile of genes linked to the hunger-satiety circuit, without altering monoaminergic transmission. In conclusion, the novel CB1 antagonist compound NESS038C6 may represent a useful candidate agent for the treatment of obesity and its metabolic complications, without or with reduced side effects relative to those instead observed with rimonabant. Copyright © 2012 Elsevier B.V. All rights reserved.

  16. Evaluation of the C6 Lyme Enzyme Immunoassay for the Diagnosis of Lyme Disease in Children and Adolescents.

    Lipsett, Susan C; Branda, John A; McAdam, Alexander J; Vernacchio, Louis; Gordon, Caroline D; Gordon, Catherine R; Nigrovic, Lise E

    2016-10-01

    The commercially-available C6 Lyme enzyme immunoassay (EIA) has been approved to replace the standard whole-cell sonicate EIA as a first-tier test for the diagnosis of Lyme disease and has been suggested as a stand-alone diagnostic. However, the C6 EIA has not been extensively studied in pediatric patients undergoing evaluation for Lyme disease. We collected discarded serum samples from children and adolescents (aged ≤21 years) undergoing conventional 2-tiered testing for Lyme disease at a single hospital-based clinical laboratory located in an area endemic for Lyme disease. We performed a C6 EIA on all collected specimens, followed by a supplemental immunoblot if the C6 EIA result was positive but the whole-cell sonicate EIA result was negative. We defined a case of Lyme disease as either a clinician-diagnosed erythema migrans lesion or a positive standard 2-tiered serologic result in a patient with symptoms compatible with Lyme disease. We then compared the performance of the C6 EIA alone and as a first-tier test followed by immunoblot, with that of standard 2-tiered serology for the diagnosis of Lyme disease. Of the 944 specimens collected, 114 (12%) were from patients with Lyme disease. The C6 EIA alone had sensitivity similar to that of standard 2-tiered testing (79.8% vs 81.6% for standard 2-tiered testing; P = .71) with slightly lower specificity (94.2% vs 98.8% 2; P Lyme disease, the C6 EIA could guide initial clinical decision making, although a supplemental immunoblot should still be performed. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

  17. Mode of action of pectin lyase A of Aspergillus niger on differently C(6)-substituted oligogalacturonides.

    van Alebeek, Gert-Jan W M; Christensen, Tove M I E; Schols, Henk A; Mikkelsen, Jørn D; Voragen, Alphons G J

    2002-07-19

    A thorough investigation of the mode of action of Aspergillus niger (4M-147) pectin lyase A (PLA) on differently C(6)-substituted oligogalacturonides is described. PLA appeared to be very specific for fully methyl-esterified oligogalacturonides: removal of the methyl-ester or changing the type of ester (ethyl esterification) or transamidation resulted in (almost) complete loss of conversion. The PLA activity increased with increasing length of the substrate up to a degree of polymerization (DP) of 8 indicating the presence of at least eight subsites on the enzyme. Product analysis demonstrated the formation of several Delta 4,5 unsaturated products and their saturated counterparts. The Delta 4,5 unsaturated trimer was the main product up to DP 8. For DP 9 and 10 Delta 4,5 unsaturated tetramer was the major product. Based upon the bond cleavage frequencies, a provisional subsite map was calculated, which supports the presence of eight subsites. By limited alkaline de-esterification of fully methyl-esterified pentamer and hexamer two sets of partially methyl-esterified pentamers (x and y methyl groups) and hexamers (a and b methyl groups) were prepared. Matrix-assisted laser desorption/ionization time of flight mass spectroscopy (MALDI-TOF MS) analysis demonstrated that the methyl-ester distribution was fully random. Using these partially methyl-esterified oligogalacturonides as substrates for PLA a 10-fold decrease in reaction rate was recorded compared with the fully methyl-esterified counterparts. Analysis of the methyl-ester distribution of the products showed that PLA tolerates carboxyl groups in the substrate binding cleft. At either subsite +2, +4, or -1 to -4 a free carboxyl group could be tolerated, whereas methyl-esters were obligatory at subsite +1 and +3. So PLA is capable to cleave the bond between a methyl-esterified and a non-esterified galacturonic acid residue, where the newly formed Delta 4,5 unsaturated non-reducing end residue always contains a

  18. Coarsening of (Fe, Cr)23C6 carbide phase on the tempering of 14Kh17N2 chromium-nickel steel

    Psarev, V.I.

    2002-01-01

    Paper lists the results of computer analysis of distribution according to sizes (Fe, Cr) 23 C 6 microparticles resulting from 14Kh17N2 steel tempering under 700 Deg C. Data were obtained at the maximum beneficial magnification of a light microscope. The mentioned curves of distribution densities are characterized by more reliable run from most permissible sizes of dispersed particles. Application of general rules of distributions and of previously elaborated procedure to identify experimental histograms with theoretical distributions enables to derive valuable information on dynamics of coarsening of a disperse phase in this case, as well [ru

  19. Microprocessor-based integration of microfluidic control for the implementation of automated sensor monitoring and multithreaded optimization algorithms.

    Ezra, Elishai; Maor, Idan; Bavli, Danny; Shalom, Itai; Levy, Gahl; Prill, Sebastian; Jaeger, Magnus S; Nahmias, Yaakov

    2015-08-01

    Microfluidic applications range from combinatorial synthesis to high throughput screening, with platforms integrating analog perfusion components, digitally controlled micro-valves and a range of sensors that demand a variety of communication protocols. Currently, discrete control units are used to regulate and monitor each component, resulting in scattered control interfaces that limit data integration and synchronization. Here, we present a microprocessor-based control unit, utilizing the MS Gadgeteer open framework that integrates all aspects of microfluidics through a high-current electronic circuit that supports and synchronizes digital and analog signals for perfusion components, pressure elements, and arbitrary sensor communication protocols using a plug-and-play interface. The control unit supports an integrated touch screen and TCP/IP interface that provides local and remote control of flow and data acquisition. To establish the ability of our control unit to integrate and synchronize complex microfluidic circuits we developed an equi-pressure combinatorial mixer. We demonstrate the generation of complex perfusion sequences, allowing the automated sampling, washing, and calibrating of an electrochemical lactate sensor continuously monitoring hepatocyte viability following exposure to the pesticide rotenone. Importantly, integration of an optical sensor allowed us to implement automated optimization protocols that require different computational challenges including: prioritized data structures in a genetic algorithm, distributed computational efforts in multiple-hill climbing searches and real-time realization of probabilistic models in simulated annealing. Our system offers a comprehensive solution for establishing optimization protocols and perfusion sequences in complex microfluidic circuits.

  20. Densities, viscosities, and refractive indexes for {C2H5CO2(CH2)2CH3+C6H13OH+C6H6} at T=308.15 K

    Casas, Herminio; Garcia-Garabal, Sandra; Segade, Luisa; Cabeza, Oscar.; Franjo, Carlos; Jimenez, Eulogio

    2003-01-01

    In this work we present densities, kinematic viscosities, and refractive indexes of the ternary system {C 2 H 5 CO 2 (CH 2 ) 2 CH 3 +C 6 H 13 OH+C 6 H 6 } and the corresponding binary mixtures {C 2 H 5 CO 2 (CH 2 ) 2 CH 3 +C 6 H 6 }, {C 2 H 5 CO 2 (CH 2 ) 2 CH 3 +C 6 H 13 OH}, and {C 6 H 13 OH+C 6 H 6 }. All data have been measured at T=308.15 K and atmospheric pressure over the whole composition range. The excess molar volumes, dynamic viscosity deviations, and changes of the refractive index on mixing were calculated from experimental measurements. The results for binary mixtures were fitted to a polynomial relationship to estimate the coefficients and standard deviations. The Cibulka equation has been used to correlate the experimental values of ternary mixtures. Also, the experimental values obtained for the ternary mixture were used to test the empirical methods of Kohler, Jacob and Fitzner, Colinet, Tsao and Smith, Toop, Scatchard et al., and Hillert. These methods predict excess properties of the ternary mixtures from those of the involved binary mixtures. The results obtained for dynamic viscosities of the binary mixtures were used to test the semi-empirical relations of Grunberg-Nissan, McAllister, Auslaender, and Teja-Rice. Finally, the experimental refractive indexes were compared with the predicted results for the Lorentz-Lorenz, Gladstone-Dale, Wiener, Heller, and Arago-Biot equations. In all cases, we give the standard deviation between the experimental data and that calculated with the above named relations

  1. The change of p16 gene expression in glioma cell line C6 after radiation with gamma knife

    Zhao Xingli; Zhao Conghai; Tian Yu

    2002-01-01

    Objective: T observe the change of expression of p16 gene product, P16 protein, after treated by gamma knife on glioma cell line C6. Methods: Glioma C6 cells proliferated in vitro, treated by γ-knife in dose of 5.00 and 6.22 Gy, respectively. P16 protein was detected by immunohistochemical technique and image analysis. Results: The P16 protein in glioma C6 cells was notably increased after treatment with γ knife (P < 0.01). The grey number in C6 group (control group) was 167.1 +- 6.2 and was 155.4 +- 2.0 and 124.9 +- 7.1, respectively, in 5.00 Gy and 6.22 Gy gamma knife treated group. Conclusion: It is suggests that one of the mechanisms of glioma cell C6 apoptosis induced by γ-knife radiation may be associated with activation of p16 gene and increase of P16 protein expression

  2. Analysis of the Aedes albopictus C6/36 genome provides insight into cell line utility for viral propagation.

    Miller, Jason R; Koren, Sergey; Dilley, Kari A; Puri, Vinita; Brown, David M; Harkins, Derek M; Thibaud-Nissen, Françoise; Rosen, Benjamin; Chen, Xiao-Guang; Tu, Zhijian; Sharakhov, Igor V; Sharakhova, Maria V; Sebra, Robert; Stockwell, Timothy B; Bergman, Nicholas H; Sutton, Granger G; Phillippy, Adam M; Piermarini, Peter M; Shabman, Reed S

    2018-03-01

    The 50-year-old Aedes albopictus C6/36 cell line is a resource for the detection, amplification, and analysis of mosquito-borne viruses including Zika, dengue, and chikungunya. The cell line is derived from an unknown number of larvae from an unspecified strain of Aedes albopictus mosquitoes. Toward improved utility of the cell line for research in virus transmission, we present an annotated assembly of the C6/36 genome. The C6/36 genome assembly has the largest contig N50 (3.3 Mbp) of any mosquito assembly, presents the sequences of both haplotypes for most of the diploid genome, reveals independent null mutations in both alleles of the Dicer locus, and indicates a male-specific genome. Gene annotation was computed with publicly available mosquito transcript sequences. Gene expression data from cell line RNA sequence identified enrichment of growth-related pathways and conspicuous deficiency in aquaporins and inward rectifier K+ channels. As a test of utility, RNA sequence data from Zika-infected cells were mapped to the C6/36 genome and transcriptome assemblies. Host subtraction reduced the data set by 89%, enabling faster characterization of nonhost reads. The C6/36 genome sequence and annotation should enable additional uses of the cell line to study arbovirus vector interactions and interventions aimed at restricting the spread of human disease.

  3. THE DISTRIBUTION OF COMMERCIAL CROWN ETHER DC18C6 AND THE EXTRACTION STUDY OF ALKALI AND EARTH ALKALI METALS

    Bambang Rusdiarso

    2010-06-01

    Full Text Available Distribution of A and B isomers of crown-ether DC18C6 on their organic and water phases (chloride, nitrate and sulphocyanide salts and extraction of alkali and earth alkali metals has been studied. In LiCl 0.1 M environment, lithium extraction could be ignored. The presence of extracted potassium metal may affect the crown ether DC18C6 distribution albeit only a little. In KNO3 0.1 M environment, the distribution coefficient values (d were 6.1 and 10.3 for A and B isomers, respectively ; while in KCl  0.1 M environment the values were 4.9 and 11.8, respectively. In KSCN 0.1 M, d values for A and B isomers were 40.4 and 36.6, respectively, which were higher than the value obtained from both KNO3 and KCl  0.1 M environments. Caesium metal extraction using DC18C6 occurred weakly, up to only 5%. Strontium extraction using DC18C6 achieved better yield than the caesium extraction. The percentage of extraction increased under organic solvent according to the following: toluene (4% < chloroform (28% < TBP (35%.   Keywords: distribution, crown-ether DC18C6, extraction.

  4. Evaluation guidelines for microprocessor-based systems important to safety

    Adams, D.M.; Svoboda, J.M.

    1983-01-01

    Proposed criteria for the application of stored-program, digital computers in commercial nuclear power plants are presented in summary form. The emphasis is on making recommendations for the design of computer systems and on recommending a method for the regulatory review of computer system designs. More-restrictive requirements are made for protection systems than control systems or other plant computer systems. In making these recommendations, the study team reviewed current regulations, past NRC reviews of computer systems, the work done by other government agencies, and the work done by many other countries. The results provide a classification of systems, a recommended design method, and a specification of design issues to be resolved during the design and development of digital computer systems

  5. RISC-type microprocessors may revolutionize aerospace simulation

    Jackson, Albert S.

    The author explores the application of RISC (reduced instruction set computer) processors in massively parallel computer (MPC) designs for aerospace simulation. The MPC approach is shown to be well adapted to the needs of aerospace simulation. It is shown that any of the three common types of interconnection schemes used with MPCs are effective for general-purpose simulation, although the bus-or switch-oriented machines are somewhat easier to use. For partial differential equation models, the hypercube approach at first glance appears more efficient because the nearest-neighbor connections required for three-dimensional models are hardwired in a hypercube machine. However, the data broadcast ability of a bus system, combined with the fact that data can be transmitted over a bus as soon as it has been updated, makes the bus approach very competitive with the hypercube approach even for these types of models.

  6. Cyclisation versus 1,1-Carboboration: Reactions of B(C6F5)3 with Propargyl Amides.

    Melen, Rebecca L; Hansmann, Max M; Lough, Alan J; Hashmi, A Stephen K; Stephan, Douglas W

    2013-09-02

    A series of propargyl amides were prepared and their reactions with the Lewis acidic compound B(C6F5)3 were investigated. These reactions were shown to afford novel heterocycles under mild conditions. The reaction of a variety of N-substituted propargyl amides with B(C6F5)3 led to an intramolecular oxo-boration cyclisation reaction, which afforded the 5-alkylidene-4,5-dihydrooxazolium borate species. Secondary propargyl amides gave oxazoles in B(C6F5)3 mediated (catalytic) cyclisation reactions. In the special case of disubstitution adjacent to the nitrogen atom, 1,1-carboboration is favoured as a result of the increased steric hindrance (1,3-allylic strain) in the 5-alkylidene-4,5-dihydrooxazolium borate species. Copyright © 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Microprocessor-controlled tester for evaluation of the Self-Energized Credential System (SECS)

    Corlis, N.E.

    1980-03-01

    The Self-Energized Credential System (SECS) was developed for use in the Plutonium Protection System (PPS) installed at Hanford, Washington. Evaluation and development of the SECS system was enhanced by the use of a microprocessor-controlled portal tester. This tester used infrared (ir) beam sensors to provide information on the direction of travel of the credential wearer and to detect inoperative credentials. A printed record of the portal number, actual code read, time, and direction of the credential passage provided information essential to an assessment of the operability of the SECS

  8. A microprocessor-based gamma-ray spectrometer with gain stabilized single-channel analyzers

    Borg, P.J.; Huppert, P.; Phillips, P.L.; Waddington, P.J.

    1985-01-01

    The design and performance of a self-contained microprocessor-based gamma-ray spectrometer for use in geophysical measurements using nuclear techniques is described. The instrument uses single-channel analyzers which are inherently simpler and faster than the Wilkinson or successive approximation ADC. A novel technique of gain stabilization together with a simple means of energy calibration has been developed. The modular design of the equipment makes it suitable for multidetector usage, required in a number of nucleonic gauges for the quantitative measurement of chemical constituents. (orig.)

  9. Microprocessor-controlled data-acquisition instrument for neutron-activation measurements

    Jones, B.A.

    1981-01-01

    This paper describes a microprocessor controlled data acquisition instrument designed at Lawrence Livermore National Laboratory to provide experimenters with a diagnostic tool for measuring the performance of laser imploded fusion targets via neutron activation techniques. This instrument features the ability to count four independent inputs simultaneously while providing a front panel readout of these inputs, plus a time of day clock. A hardcopy printout of the data is also provided by a built-in thermal printer. All running modes and parameters are user selectable via a front panel keypad, and a complete set of internal self-testing diagnostics are available for debug

  10. ITRA 084 - a microprocessor controlled rapid analyzer in mining and metallurgy

    Kliem, V.; Kreher, M.; Boy, N.

    1986-01-01

    A new rapid analyzer of the ITRA series has been developed at the Freiberg Research Institute of Non-Ferrous Metals for single and multi-element analysis in mining and non-ferrous metallurgy. INTRA-08 represents an efficient microprocessor-controlled on-line X-ray fluorescence analyzer based on the main principles utilized with success hitherto in device engineering (isotope excitation, four-channel modification, balance filter method). A U880 single-chip microcomputer provides the central control of the device including the execution of an extensive program for the matrix correction. The efficiency of the analyzer is demonstrated taking measured values as a basis

  11. Software support for Motorola 68000 microprocessor at CERN. CERN convention for programming the MC68000 family

    Cailliau, R.; Carpenter, B.

    1984-01-01

    The CERN convention for programming the MC68000 family of microprocessors gives a set of rules describing the layout of the memory and stack frames used by routines as they should appear before and after their calling sequences. It does not deal with the instructions used to achieve these states. The aim of the convention is to allow programming language mixing as well as debugging of programs built from units written in different languages. It is to be followed by programmers and programming-language compilers. (orig.)

  12. Wide-bandwidth low-voltage PLL for powerPC(sup TM) microprocessors

    Alvarez, Jose; Sanchez, Hector; Gerosa, Gianfranco; Countryman, Roger

    1995-04-01

    A 3.3 V Phase-Locked-Loop (PLL) clock synthesizer implemented in 0.5 micron CMOS technology is described. The PLL supports internal to external clock frequency ratios of 1, 1.5, 2, 3, and 4 as well as numerous static power down modes for PowerPC(sup TM) microprocessors. The CPU clock lock range spans from 6 to 175 MHz. Lock times below 15 mu s, PLL power dissipation below 10mW as well as phase error and jitter below +/- 100 ps have been measured. The total area of the PLL is 0.52 mm(exp 2).

  13. Microprocessor-based data acquisition system for extensive air shower studies

    Mazumdar, G.K.D.; Kalita, P.M.; Bordoloi, T.C.; Pathak, K.M.

    1989-01-01

    Studies on electromagnetic radiation from large extensive air showers (Esub(p) ≥> 10 16 eV) have been of recent importance in the investigation of properties of EAS in problems involving mass composition, arrival time, radio emission. Cerenkov radiation etc. Such studies need fast electronic circuitry preferably for digitisation. A microprocessor based data acquisition system having scintillation counters, PA, MA, Pd, S/H and control unit has been developed and is being used in the EAS studies at Gauhati University Cosmic Ray Research Laboratory. Description of the different units along with their functioning and method of standardisation is presented in this paper. (author). 3 figs

  14. A high resolution wire scanner beam profile monitor with a microprocessor data acquisition system

    Cutler, R.I.; Mohr, D.L.; Whittaker, J.K.; Yoder, N.R.

    1983-01-01

    A beam profile monitor has been constructed for the NBS-LANL Racetrack Microtron. The monitor consists of two perpendicular 30 μm diameter carbon wires that are driven through an electron beam by a pneumatic actuator. A long-lifetime, electroformed nickel bellows is used for the linear-motion vacuum feedthrough. Secondary emission current from the wires and a signal from a transducer measuring the position of the wires are simultaneously digitized by a microprocessor to yield beam current density profiles in two dimensions. The wire scanner is designed for use with both pulsed and cw beams

  15. Microprocessor-based control for independently-phased RF linac cavities

    Dawson, J.W.

    1979-01-01

    A microprocessor based system has been built to control the RF amplifiers associated with independently phased linac cavities. The system has an 8080A at each amplifier station, together with associated ROM, RAM, I/O, etc. At a central NOVA 3 computer an additional 8080A system is incorporated in the interface to the NOVA I/O bus. The NOVA interface is connected by a bus of eighteen twisted pairs to each amplifier station, providing bilateral transmission between each station and the NOVA. The system architecture, bus protocol, and operating characteristics are described

  16. Microprocessor isotope gauges for measurement of coating thickness and of air dust pollution

    Machaj, B.; Zrudelny, F.; Sikora, A.; Jaszczuk, J.

    1986-01-01

    The article describes a coating thickness gauge based on measurement of backscattered beta particles, and an air dust pollution gauge based on measurement of dust deposited from known volume of ambient air passed through a filter, by attenuation of beta radiation. In both cases to control the gauges and to process head signals microcomputer system based on Intel 8080 microprocessor is employed. Algorithms for processing and control of the gauges and corresponding flow charts are presented. Block diagram of microcomputer system used is presented, as well as the manner of operation of the gauges. (author)

  17. Effect of fluoxetine and adenosine receptor NECA agonist on G alpha q/11 protein of C6 glioma cells

    Kovářů, H.; Kovářů, F.; Lisá, Věra

    2012-01-01

    Roč. 33, č. 6 (2012), s. 614-618 ISSN 0172-780X Institutional support: RVO:67985823 Keywords : C6 glioma cells * SSRI antidepressant * G alpha q/11 signalling * G protein coupled receptor Subject RIV: ED - Physiology Impact factor: 0.932, year: 2012

  18. 26 CFR 1.642(c)-6 - Valuation of a remainder interest in property transferred to a pooled income fund.

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Valuation of a remainder interest in property... § 1.642(c)-6 Valuation of a remainder interest in property transferred to a pooled income fund. (a) In... transferred property on the valuation date. The fact that the income beneficiary may not receive the last...

  19. Monitoring in real time the effect of TLX overexpression on proliferation and migration of C6 cells.

    Li, G L; Fang, S H; Xu, B

    2017-01-01

    Orphan nuclear receptor TLX has been shown to play an essential role in regulating the self-renewal and proliferation of neural stem cells (NSCs). However, TLX overexpression in NSCs induces long-term NSC expansion and further leads to glioma initiation in mouse when combined with p53 mutations. Whether overexpression of TLX plays a role in glioma stem cell (GSC) proliferation and migration still remains largely unknown. In this study, we infected C6 cells, a special glioma cell line which is mainly composed of cancer stem cells(CSCs), with lentiviruses expressing GFP(LV-GFP) or GFP-T2A-TLX(LV-TLX) and then monitored cell proliferation and migration using the real-time analyzer system (RTCA, xCELLigence, Roche). We found that the cell index (CI) observed for the TLX overexpressing C6 cells showed a lower value than that of the LV-GFP transduced cells. And the MTT results correlated highly with the RTCA proliferation assessments. Furthermore, the expression of p21 was decreased while other downstream genes PTEN and p53 were not significantly changed in TLX overexpressing C6 cells . These findings strongly indicate that TLX overexpression has the ability to decrease the proliferating and migratory properties of C6 cells by targeting p21. Further, our results suggest that TLX overexpression may also have a similar inhibitory effect on GSC proliferation and migration.

  20. Insulation Strength and Decomposition Characteristics of a C6F12O and N2 Gas Mixture

    Xiaoxing Zhang

    2017-08-01

    Full Text Available This paper explores the decomposition characteristics of a new type of environmentally friendly insulating gas C6F12O and N2 mixed gas under AC voltage. The breakdown behavior of 3% C6F12O and N2 mixed gas in quasi-uniform field was investigated through a breakdown experiment. The self-recovery of the mixed gas was analyzed by 100 breakdown experiments. The decomposition products of C6F12O and N2 under breakdown voltage were determined by gas chromatography–mass spectrometer (GC-MS. Finally, the decomposition process of the products was calculated by density functional theory, and the ionization energy, affinity, and molecular orbital gap of the decomposition products were also calculated. The properties of the decomposition products were analyzed from the aspects of insulation and environmental protection. The experimental results show that the 3% C6F12O and N2 mixed gas did not show a downward trend over 100 breakdown tests under a 0.10 MPa breakdown voltage. The decomposition products after breakdown were CF4, C2F6, C3F6, C3F8, C4F10, and C5F12. The ionization energies of several decomposition products are more than 10 eV. The Global Warming Potential (GWP values of the main products are lower than SF6. C2F6, C3F8, and C4F10 have better insulation properties.

  1. Development of a mathematical model describing hydrolysis and co-fermentation of C6 and C5 sugars

    Morales Rodriguez, Ricardo; Gernaey, Krist; Meyer, Anne S.

    2010-01-01

    saccharification and co-fermentation (SSCF) of C6 and C5 sugars. Model construction has been carried out by combining existing mathematical models for enzymatic hydrolysis on the one hand and co-fermentation on the other hand. An inhibition of ethanol on cellulose conversion was introduced in order to increase...

  2. Atmospheric CO2 promoted synthesis of N-containing heterocycles over B(C6F5)3 catalyst

    Xiang Gao; Bo Yu; Qingqing Mei; Zhenzhen Yang; Yanfei Zhao; Hongye Zhang; Leiduan Hao, Zhimin Liu

    2016-01-01

    B(C 6 F 5 ) 3 combined with atmospheric CO 2 was found to be highly effective for the cyclization of ortho substituted aniline derivatives with N,N-dimethylformamide (DMF), and a series of N-containing heterocycles including benzothiazoles, benzimidazoles, quinazolinone and benzoxazole were obtained in good to excellent yields. (authors)

  3. Composition of the C6+ Fraction of Natural Gas by Multiple Porous Layer Open Tubular Capillaries Maintained at Low Temperatures.

    Burger, Jessica L; Lovestead, Tara M; Bruno, Thomas J

    2016-03-17

    As the sources of natural gas become more diverse, the trace constituents of the C 6 + fraction are of increasing interest. Analysis of fuel gas (including natural gas) for compounds with more than 6 carbon atoms (the C 6 + fraction) has historically been complex and expensive. Hence, this is a procedure that is used most often in troubleshooting rather than for day-to-day operations. The C 6 + fraction affects gas quality issues and safety considerations such as anomalies associated with odorization. Recent advances in dynamic headspace vapor collection can be applied to this analysis and provide a faster, less complex alternative for compositional determination of the C 6 + fraction of natural gas. Porous layer open tubular capillaries maintained at low temperatures (PLOT-cryo) form the basis of a dynamic headspace sampling method that was developed at NIST initially for explosives in 2009. This method has been recently advanced by the combining of multiple PLOT capillary traps into one "bundle," or wafer, resulting in a device that allows the rapid trapping of relatively large amounts of analyte. In this study, natural gas analytes were collected by flowing natural gas from the laboratory (gas out of the wall) or a prepared surrogate gas flowing through a chilled wafer. The analytes were then removed from the PLOT-cryo wafer by thermal desorption and subsequent flushing of the wafer with helium. Gas chromatography (GC) with mass spectrometry (MS) was then used to identify the analytes.

  4. Why are [P(C6H5)4]+N3- and [As(C6H5)4]+N3- Ionic Salts and Sb(C6H5)4N3 and Bi(C6H5)4N3 are Covalent Solids? A Theoretical Study Provides an Unexpected Answer

    2011-03-04

    Research, the Defense Threat Reduction Agency, and the Department of Energy. DAD is indebted to the Robert Ramsay Endowment of the University of Alabama...Schmidt, M. W., Baldridge, K. K., Boatz, J.A., Elbert, S.T., Gordon , M.S., Jensen, J.H., Koseki, S., Matsunaga, N., Nguyen, K.A., Su, S., Windus, T.L...Dupuis, M., Montgomery, J.A.; J. Comput. Chem., 1993, 14, 1347-1363.; Gordon , M. S., Schmidt, M. W., pp. 1167-1189, in "Theory and Applications of

  5. Design Example of Useful Memory Latency for Developing a Hazard Preventive Pipeline High-Performance Embedded-Microprocessor

    Ching-Hwa Cheng

    2013-01-01

    Full Text Available The existence of structural, control, and data hazards presents a major challenge in designing an advanced pipeline/superscalar microprocessor. An efficient memory hierarchy cache-RAM-Disk design greatly enhances the microprocessor's performance. However, there are complex relationships among the memory hierarchy and the functional units in the microprocessor. Most past architectural design simulations focus on the instruction hazard detection/prevention scheme from the viewpoint of function units. This paper emphasizes that additional inboard memory can be well utilized to handle the hazardous conditions. When the instruction meets hazardous issues, the memory latency can be utilized to prevent performance degradation due to the hazard prevention mechanism. By using the proposed technique, a better architectural design can be rapidly validated by an FPGA at the start of the design stage. In this paper, the simulation results prove that our proposed methodology has a better performance and less power consumption compared to the conventional hazard prevention technique.

  6. Synthesis of Acetone-Derived C6 , C9 , and C12 Carbon Scaffolds for Chemical and Fuel Applications.

    Moore, Cameron M; Jenkins, Rhodri W; Janicke, Michael T; Kubic, William L; Polikarpov, Evgueni; Semelsberger, Troy A; Sutton, Andrew D

    2016-12-20

    A simple, inexpensive catalyst system (Amberlyst 15 and Ni/SiO 2 -Al 2 O 3 ) is described for the upgrading of acetone to a range of chemicals and potential fuels. Stepwise hydrodeoxygenation of the produced ketones can yield branched alcohols, alkenes, and alkanes. An analysis of these products is provided, which demonstrates that this approach can provide a product profile of valuable bioproducts and potential biofuels. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Thermodynamic study of binary mixture of x1[C6mim][BF4] + x21-propanol: Measurements and molecular modeling

    Kermanpour, F.; Sharifi, T.

    2012-01-01

    Highlights: ► Densities and viscosities for binary mixture of {x 1 [C 6 mim][BF 4 ] + x 2 1-propanol} were measured at different temperatures. ► The excess molar functions were calculated from the obtained experimental data. ► These data were correlated with the Redlich–Kister equation and PFP model to obtain the coefficients and standard deviations. - Abstract: Densities, ρ, and viscosities, η, of pure 1-hexyl-3-methylimidazoliumtetrafluoro borate ([C 6 mim][BF 4 ]) and 1-propanol, and their binary mixture {x 1 [C 6 mim][BF 4 ] + x 2 1-propanol} were measured at atmospheric pressure and in the temperature range of 293.15–333.15 K. The excess molar volumes, V m E , thermal expansion coefficients, α, and their excess values, α E , isothermal coefficient of excess molar enthalpy, (∂H m E /∂p) T,x and excess viscosities, η E , were calculated from the experimental values of densities and viscosities. The excess molar volumes of the binary mixture are negative over the entire mole fraction range and increase with increasing temperature. Excess viscosities are negative over the entire mole fraction range of the mixture and decrease with increasing temperature. The obtained excess molar volumes and excess viscosities were correlated with the Redlich–Kister equation. The experimental results have also been used to examine the applicability of Prigogine–Flory–Patterson (PFP) theory in predicting the excess molar volume of the binary mixture. It is indicated that agreement between excess molar volumes calculated via PFP theory and the experimental results is good in all temperatures.

  8. (C6H13N)2BiI5: A One-Dimensional Lead-Free Perovskite-Derivative Photoconductive Light Absorber.

    Zhang, Weichuan; Tao, Kewen; Ji, Chengmin; Sun, Zhihua; Han, Shiguo; Zhang, Jing; Wu, Zhenyue; Luo, Junhua

    2018-04-16

    Lead-free organic-inorganic hybrid perovskites have recently attracted intense interest as environmentally friendly, low-cost, chemically stable light absorbers. Here, we reported a new one-dimensional (1D) zigzag chainlike light-absorbing hybrid material of (C 6 H 13 N) 2 BiI 5 , in which the corner-sharing octahedral bismuth halide chains are surrounded by organic cations of tetramethylpiperidinium. This unique zigzag 1D hybrid perovskite-derivative material shows a narrow direct band gap of 2.02 eV and long-lived photoluminescence, which is encouraging for optoelectronic applications. Importantly, it behaves as a typical semiconducting material and displays obvious photoresponse in the visible-light range. This work opens a potential pathway for the further application of 1D lead-free hybrids.

  9. Monolithic silicon photonics in a sub-100nm SOI CMOS microprocessor foundry: progress from devices to systems

    Popović, Miloš A.; Wade, Mark T.; Orcutt, Jason S.; Shainline, Jeffrey M.; Sun, Chen; Georgas, Michael; Moss, Benjamin; Kumar, Rajesh; Alloatti, Luca; Pavanello, Fabio; Chen, Yu-Hsin; Nammari, Kareem; Notaros, Jelena; Atabaki, Amir; Leu, Jonathan; Stojanović, Vladimir; Ram, Rajeev J.

    2015-02-01

    We review recent progress of an effort led by the Stojanović (UC Berkeley), Ram (MIT) and Popović (CU Boulder) research groups to enable the design of photonic devices, and complete on-chip electro-optic systems and interfaces, directly in standard microelectronics CMOS processes in a microprocessor foundry, with no in-foundry process modifications. This approach allows tight and large-scale monolithic integration of silicon photonics with state-of-the-art (sub-100nm-node) microelectronics, here a 45nm SOI CMOS process. It enables natural scale-up to manufacturing, and rapid advances in device design due to process repeatability. The initial driver application was addressing the processor-to-memory communication energy bottleneck. Device results include 5Gbps modulators based on an interleaved junction that take advantage of the high resolution of the sub-100nm CMOS process. We demonstrate operation at 5fJ/bit with 1.5dB insertion loss and 8dB extinction ratio. We also demonstrate the first infrared detectors in a zero-change CMOS process, using absorption in transistor source/drain SiGe stressors. Subsystems described include the first monolithically integrated electronic-photonic transmitter on chip (modulator+driver) with 20-70fJ/bit wall plug energy/bit (2-3.5Gbps), to our knowledge the lowest transmitter energy demonstrated to date. We also demonstrate native-process infrared receivers at 220fJ/bit (5Gbps). These are encouraging signs for the prospects of monolithic electronics-photonics integration. Beyond processor-to-memory interconnects, our approach to photonics as a "More-than- Moore" technology inside advanced CMOS promises to enable VLSI electronic-photonic chip platforms tailored to a vast array of emerging applications, from optical and acoustic sensing, high-speed signal processing, RF and optical metrology and clocks, through to analog computation and quantum technology.

  10. Design of a microprocessor-based Control, Interface and Monitoring (CIM unit for turbine engine controls research

    Delaat, J. C.; Soeder, J. F.

    1983-01-01

    High speed minicomputers were used in the past to implement advanced digital control algorithms for turbine engines. These minicomputers are typically large and expensive. It is desirable for a number of reasons to use microprocessor-based systems for future controls research. They are relatively compact, inexpensive, and are representative of the hardware that would be used for actual engine-mounted controls. The Control, Interface, and Monitoring Unit (CIM) contains a microprocessor-based controls computer, necessary interface hardware and a system to monitor while it is running an engine. It is presently being used to evaluate an advanced turbofan engine control algorithm.

  11. Human/murine chimeric 81C6 F(ab')2 fragment: preclinical evaluation of a potential construct for the targeted radiotherapy of malignant glioma

    Boskovitz, Abraham; Akabani, Gamal H.; Pegram, Charles N.; Bigner, Darrell D.; Zalutsky, Michael R.

    2004-01-01

    We have obtained encouraging responses in recent Phase I studies evaluating 131 I-labeled human/murine chimeric 81C6 anti-tenascin monoclonal antibody (ch81C6) administered into surgically-created tumor resection cavities in brain tumor patients. However, because the blood clearance is slow, hematologic toxicity has been higher than seen with murine 81C6 (mu81C6). In the current study, a series of paired-label experiments were performed in athymic mice bearing subcutaneous D-245 MG human glioma xenografts to compare the biodistribution of the fragment ch81C6 F(ab') 2 labeled using Iodogen to a) intact ch81C6, b) mu81C6, and c) ch81C6 F(ab') 2 labeled using N-succinimidyl 3-[ 131 I]iodobenzoate. Tumor retention of radioiodine activity for the F(ab') 2 fragment was comparable to that for intact ch81C6 for the first 24 h and to that for mu81C6 for the first 48 h; as expected, blood and other normal tissue levels declined faster for ch81C6 F(ab') 2. Radiation dosimetry calculations suggest that 131 I-labeled ch81C6 F(ab') 2 may warrant further evaluation as a targeted radiotherapeutic for the treatment of brain tumors

  12. The HXR80M-balloon experiment: a microprocessor-controlled transatlantic payload

    Ubertini, P.; Bazzano, A.; Boccaccini, L.

    1980-01-01

    Following the results obtained from the succesful transatlantic flight launched during the summer 1976 from the CNR Milo Base, Sicily, the Laboratorio di Astrofisica Spaziale has started a new program in the hard X-ray astronomy field. It basically consists in the development of high resolution large area Multiwire Proportional Chambers to be employed in long duration balloon flights to study and monitor galactic and extragalactic sources. This note will describe the flight configuration and performances of the HXR80M payload. The experiment is expected to fly during July 1980 from the Milo Base in the framework of the CNR experimental balloon campaign. The note will analyze the main characteristics of the detectors employed, of the data handling electronics and in particular of the hardware and the software of the on-board microprocessor controlled multichannel analyzer. In fact the limitation due to the low bit rate HF link (1.2kbit/s) and the long flight duration (about one week) make imperative the use of an on-board microprocessor system to handle and select in real time the scientific data and to control the housekeeping and the telecommand systems

  13. Electric protections based in microprocessors in power plants; Protecciones electricas basadas en microprocesadores en centrales generadoras

    Libreros, Domitilo; Castanon Jimenez, Jose Ismael [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1988-12-31

    This article is centered around the substitution of the conventional electric protections of a power plant in connection type unit for protections based in microprocessors. A general model of conventional protection of a power plant is described and the number of analogic and digital signals that intervene in that model are quantified. A model is setup for power plant protection with microprocessors, analyzing each one of the modules that would form it. Finally, the algorithms to carry on such protection are presented. [Espanol] Este articulo se centra en torno a la sustitucion de las protecciones electricas convencionales de una central generadora en conexion tipo unidad por protecciones basadas en microprocesadores. Se describe el modelo general de proteccion convencional de una central generadora y se cuantifica el numero de senales analogicas y digitales que interviene en dicho modelo. Se propone un modelo para proteccion de centrales generadoras mediante microprocesadores, analizandose cada uno de los modulos que lo conformarian. Finalmente, se presentan los algoritmos para realizar dicha proteccion.

  14. Electric protections based in microprocessors in power plants; Protecciones electricas basadas en microprocesadores en centrales generadoras

    Libreros, Domitilo; Castanon Jimenez, Jose Ismael [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1987-12-31

    This article is centered around the substitution of the conventional electric protections of a power plant in connection type unit for protections based in microprocessors. A general model of conventional protection of a power plant is described and the number of analogic and digital signals that intervene in that model are quantified. A model is setup for power plant protection with microprocessors, analyzing each one of the modules that would form it. Finally, the algorithms to carry on such protection are presented. [Espanol] Este articulo se centra en torno a la sustitucion de las protecciones electricas convencionales de una central generadora en conexion tipo unidad por protecciones basadas en microprocesadores. Se describe el modelo general de proteccion convencional de una central generadora y se cuantifica el numero de senales analogicas y digitales que interviene en dicho modelo. Se propone un modelo para proteccion de centrales generadoras mediante microprocesadores, analizandose cada uno de los modulos que lo conformarian. Finalmente, se presentan los algoritmos para realizar dicha proteccion.

  15. Novel applications of non-volatile memories

    Duthie, I

    1982-01-01

    The author reviews briefly the evolution of the programmable memory and the alternative technologies, before discussing the operation of a small EEPROM when used in conjunction with a microprocessor for typical applications. Some applications are reviewed and the opportunities which eeproms can offer for new applications are presented, together with the requirements for artificial intelligence to become a reality.

  16. Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by 12C6+ ions

    Liu Yang; Zhang Hong; Zhang Luwei

    2008-01-01

    The aim of this work is to identify if there is sex specificity on 12 C 6+ ion-induced oxidative damage in mouse lung at different time points. Kun-Ming mice were divided into two groups, each composed of six males and six females: control group and irradiation group with a single acute dose of 4 Gy. Animals were sacrificed at 2, 4 and 12 h respectively, there lungs were removed immediately, and the oxidative stress-related biomarkers were measured by Diagnostic Reagent Kits. The results showed that the relative activities of superoxide dismutase (4 h), catalase (2 h) and Se-dependent glutathione peroxidase (12 h) have significant changes (P 12 C 6+ ion is pronounced in the lungs of males. We thought that these sex-responded differences may be attributed to the influence of sex hormones. (authors)

  17. Evaluation of radiation effects against C6 glioma in combination with vaccinia virus-p53 gene therapy

    Gridley, D. S.; Andres, M. L.; Li, J.; Timiryasova, T.; Chen, B.; Fodor, I.; Nelson, G. A. (Principal Investigator)

    1998-01-01

    The primary objective of this study was to evaluate the antitumor effects of recombinant vaccinia virus-p53 (rVV-p53) in combination with radiation therapy against the C6 rat glioma, a p53 deficient tumor that is relatively radioresistant. VV-LIVP, the parental virus (Lister strain), was used as a control. Localized treatment of subcutaneous C6 tumors in athymic mice with either rVV-p53 or VV-LIVP together with tumor irradiation resulted in low tumor incidence and significantly slower tumor progression compared to the agents given as single modalities. Assays of blood and spleen indicated that immune system activation may account, at least partly, for the enhance tumor inhibition seen with combined treatment. No overt signs of treatment-related toxicity were noted.

  18. Raman spectroscopy of few-layer graphene prepared by C2–C6 cluster ion implantation

    Wang, Z.S.; Zhang, R.; Zhang, Z.D.; Huang, Z.H.; Liu, C.S.; Fu, D.J.; Liu, J.R.

    2013-01-01

    Few-layer graphene has been prepared on 300 nm-thick Ni films by C 2 –C 6 cluster ion implantation at 20 keV/cluster. Raman spectroscopy reveals significant influence of the number of atoms in the cluster, the implantation dose, and thermal treatment on the structure of the graphene layers. In particular, the graphene samples exhibit a sharp G peak at 1584 cm −1 and 2D peaks at 2711–2717 cm −1 . The I G /I 2D ratios higher than 1.70 and I G /I D ratio as high as 1.95 confirm that graphene sheets with low density of defects have been synthesized with much improved quality by ion implantation with larger clusters of C 4 –C 6

  19. Investigation of instability of M23C6 particles in F82H steel under electron and ion irradiation conditions

    Kano, Sho; Yang, Huilong; Shen, Jingjie; Zhao, Zishou; McGrady, John; Hamaguchi, Dai; Ando, Mamami; Tanigawa, Hiroyasu; Abe, Hiroaki

    2018-04-01

    In order to clarify the instability of M23C6 in F82H steel under irradiation, both electron irradiation using a high voltage electron microscope (HVEM) and ion irradiation using an ion accelerator were performed. For the electron irradiation, in-situ observation under 2 MV electron irradiation and ex-situ high resolution electron microscopic (HREM) analysis were utilized to evaluate the response of M23C6 against irradiation. The temperature dependence of the irradiation induced instability of the carbide was first confirmed: 293 K indicating severe loss of crystallinity due to dissolution of the constituent atoms though irradiation-enhanced diffusion under the vacancy diffusion by the focused electron beam irradiation. For the ion irradiation, 10.5 MeV-Fe3+ ion was applied to bombard the F82H steel at 673 K to achieve the displacement damage of ≈20 dpa at the depth of 1.0 μm from surface. Cross-section TEM specimens were prepared by a focused ion beam technique. The shrinkage of carbide particles was observed especially near the irradiation surface. Besides, the lattice fringes at the periphery of carbide were observed in the irradiated M23C6 by the HREM analysis, which is different from that observed in the electron irradiation. It was clarified that the instability of M23C6 is dependent on the irradiation conditions, indicating that the flow rate of vacancy type defects might be the key factor to cause the dissolution of constituent atoms of carbide particles into matrix under irradiation.

  20. N-(4-Hydroxyphenyl) retinamide potentiated paclitaxel for cell cycle arrest and apoptosis in glioblastoma C6 and RG2 cells

    Janardhanan, Rajiv; Butler, Jonathan T.; Banik, Naren L.; Ray, Swapan K.

    2009-01-01

    Glioblastoma grows aggressively due to its ability to maintain abnormally high potentials for cell proliferation. The present study examines the synergistic actions of N-(4-hdroxyphenyl) retinamide (4-HPR) and paclitaxel (PTX) to control the growth of rat glioblastoma C6 and RG2 cell lines. 4-HPR induced astrocytic differentiation was accompanied by increased expression of the tight junction protein e-cadherin and sustained down regulation of Id2 (member of inhibitor of differentiation family...

  1. Coherent Structure in Solar Wind C$^{6+}$/C$^{4+}$ Ionic Composition Data During the Quiet-Sun Conditions of 2008

    Edmondson, J. K.; Lynch, B. J.; Lepri, S. T.; Zurbuchen, T. H.

    2013-01-01

    This analysis offers evidence of characteristic scale sizes in solar wind charge state data measured in-situ for thirteen quiet-sun Carrington rotations in 2008. Using a previously established novel methodology, we analyze the wavelet power spectrum of the charge state ratio C$^{6+}$/C$^{4+}$ measured in-situ by ACE/SWICS for 2-hour and 12-minute cadence. We construct a statistical significance level in the wavelet power spectrum to quantify the interference effects arising from filling missi...

  2. Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor.

    Papadopoulos, V; Guarneri, P; Kreuger, K E; Guidotti, A; Costa, E

    1992-01-01

    The C6-2B glioma cell line, rich in mitochondrial receptors that bind with high affinity to benzodiazepines, imidazopyridines, and isoquinolinecarboxamides (previously called peripheral-type benzodiazepine receptors), was investigated as a model to study the significance of the polypeptide diazepam binding inhibitor (DBI) and the putative DBI processing products on mitochondrial receptor-regulated steroidogenesis. DBI and its naturally occurring fragments have been found to be present in high...

  3. Thermodynamic study of charge-transfer complex of iodine with HT18C6 in chloroform solution

    Mahmoud Javadian Jazi

    2008-08-01

    Full Text Available A spectrophotometric study concerning the interaction between HT18C6 as n-donor and I2 as σ-acceptor has been performed in chloroform solution at different temperatures. The results are indicative of the formation 1:1 complex through equilibrium reaction. The stability constant of the complex at 7, 13, 19 and 25 oC is obtained by the computer-fitting of absorbance-mole ratio data in MATLAB software. The ΔHo and ΔSo values are obtained by the Vant Hoff method. The obtained data show that the complex is enthalpy stabilized and entropy destabilized. The entropy destabilitization is attributed to the decrease of the entropy of the free donor upon complexation. Comparison of the data from this work with those of previous works done on 18C6-I2 and HA18C6-I2 is indicative of different stability, stoichiometry and products. The possible reasons for such differences are discussed.

  4. Topologically guided tuning of Zr-MOF pore structures for highly selective separation of C6 alkane isomers

    Wang, Hao; Dong, Xinglong; Lin, Junzhong; Teat, Simon J.; Jensen, Stephanie; Cure, Jeremy; Alexandrov, Eugeny V.; Xia, Qibin; Tan, Kui; Wang, Qining; Olson, David H.; Proserpio, Davide M.; Chabal, Yves J.; Thonhauser, Timo; Sun, Junliang; Han, Yu; Li, Jing

    2018-01-01

    As an alternative technology to energy intensive distillations, adsorptive separation by porous solids offers lower energy cost and higher efficiency. Herein we report a topology-directed design and synthesis of a series of Zr-based metal-organic frameworks with optimized pore structure for efficient separation of C6 alkane isomers, a critical step in the petroleum refining process to produce gasoline with high octane rating. Zr6O4(OH)4(bptc)3 adsorbs a large amount of n-hexane but excluding branched isomers. The n-hexane uptake is ~70% higher than that of a benchmark adsorbent, zeolite-5A. A derivative structure, Zr6O4(OH)8(H2O)4(abtc)2, is capable of discriminating all three C6 isomers and yielding a high separation factor for 3-methylpentane over 2,3-dimethylbutane. This property is critical for producing gasoline with further improved quality. Multicomponent breakthrough experiments provide a quantitative measure of the capability of these materials for separation of C6 alkane isomers. A detailed structural analysis reveals the unique topology, connectivity and relationship of these compounds.

  5. Topologically guided tuning of Zr-MOF pore structures for highly selective separation of C6 alkane isomers

    Wang, Hao [Rutgers Univ., Piscataway, NJ (United States). Department of Chemistry and Chemical Biology; Dong, Xinglong [King Abdullah University of Science and Technology, Thuwal (Saudi Arabia). Advanced Membranes and Porous Materials Center, Physical Sciences and Engineering Division; Lin, Junzhong [Peking University, Beijing (China). College of Chemistry and Molecular Engineering; Teat, Simon J. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS); Jensen, Stephanie [Wake Forest University, Winston-Salem, NC (United States). Department of Physics; Cure, Jeremy [Univ. of Texas-Dallas, Richardson, TX (United States). Department of Materials Science & Engineering; Alexandrov, Eugeny V. [Samara University (Russia). Samara Center for Theoretical Materials Science (SCTMS; Xia, Qibin [Rutgers Univ., Piscataway, NJ (United States). Department of Chemistry and Chemical Biology; South China University of Technology, Guangzhou (China). School of Chemistry and Chemical Engineering; Tan, Kui [Univ. of Texas-Dallas, Richardson, TX (United States). Department of Materials Science & Engineering; Wang, Qining [Rutgers Univ., Piscataway, NJ (United States). Department of Chemistry and Chemical Biology; Olson, David H. [Rutgers Univ., Piscataway, NJ (United States). Department of Chemistry and Chemical Biology; Proserpio, Davide M. [Samara University (Russia). Samara Center for Theoretical Materials Science (SCTMS; Università degli Studi di Milano, Milano (Italy). Dipartimento di Chimica; Chabal, Yves J. [Univ. of Texas-Dallas, Richardson, TX (United States). Department of Materials Science & Engineering; Thonhauser, Timo [Wake Forest University, Winston-Salem, NC (United States). Department of Physics; Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Department of Chemistry; Sun, Junliang [Peking University, Beijing (China). College of Chemistry and Molecular Engineering; Han, Yu [King Abdullah University of Science and Technology, Thuwal (Saudi Arabia). Advanced Membranes and Porous Materials Center, Physical Sciences and Engineering Division; Li, Jing [Rutgers Univ., Piscataway, NJ (United States). Department of Chemistry and Chemical Biology

    2018-05-01

    As an alternative technology to energy intensive distillations, adsorptive separation by porous solids offers lower energy cost and higher efficiency. Herein we report a topology-directed design and synthesis of a series of Zr-based metal-organic frameworks with optimized pore structure for efficient separation of C6 alkane isomers, a critical step in the petroleum refining process to produce gasoline with high octane rating. Zr6O4(OH)4(bptc)3 adsorbs a large amount of n-hexane but excluding branched isomers. The n-hexane uptake is ~70% higher than that of a benchmark adsorbent, zeolite-5A. A derivative structure, Zr6O4(OH)8(H2O)4(abtc)2, is capable of discriminating all three C6 isomers and yielding a high separation factor for 3-methylpentane over 2,3-dimethylbutane. This property is critical for producing gasoline with further improved quality. Multicomponent breakthrough experiments provide a quantitative measure of the capability of these materials for separation of C6 alkane isomers. A detailed structural analysis reveals the unique topology, connectivity and relationship of these compounds.

  6. Protective effect of diallyl disulfide against the irradiation damage in mice induced by "1"2C"6"+ ion beams

    Xu Shuai; Ma Xiaofei; Zhang Hong; Liu Yang

    2013-01-01

    The radioprotective effect of Diallyl disulfide (DADS) on "1"2C"6"+ ion irradiation was studied. Pretreated with DADS of different concentration, male Kung-Ming mice were exposed to whole body irradiation with dosage of 4 Gy "1"2C"6"+ ion. The animals were sacrificed after irradiation. Then the bone marrow cells micronucleus rate, malondialdehyde (MDA) levels, content of protein carbonylation, total antioxidant capacity (T-AOC) and alanine aminotransferase (ALT) activity were measured. As compared with those in irradiated group, the ratio of micronucleus cells in marrow and the hepatic ALT activity in the pretreatment group with low dose DADS decreased significantly (p < O.OOl). Similarly, the content of protein carbonylation and the levels of MDA dropped dramatically in the group with middle dose DADS treatment (p < 0.05). On the contrary, the hepatic T-AOC increased markedly in the group of pretreatment with low dose DADS (p < 0.05). The results showed that DADS protect lipoid, protein and genetic material from "1"2C"6"+ ion irradiation by right of resisting oxidative stress. (authors)

  7. Kinetics of hydrogen peroxide elimination by astrocytes and C6 glioma cells analysis based on a mathematical model.

    Makino, Nobuo; Mise, Takeshi; Sagara, Jun-Ichi

    2008-06-01

    Oxidative stress is implicated in a variety of disorders including neurodegenerative diseases, and H(2)O(2) is important in the generation of reactive oxygen and oxidative stress. In this study, we have examined the rate of extracellular H(2)O(2) elimination and relevant enzyme activities in cultured astrocytes and C6 glioma cells and have analyzed the results based on a mathematical model. As compared with other types of cultured cells, astrocytes showed higher activity of glutathione peroxidase (GPx) but lower activities for GSH recycling. C6 cells showed relatively low GPx activity, and treatment of C6 cells with dibutyryl-cAMP, which induces astrocytic differentiation, increased catalase activity and H(2)O(2) permeation rate but exerted little effect on other enzyme activities. A mathematical model [N. Makino, K. Sasaki, N. Hashida, Y. Sakakura, A metabolic model describing the H(2)O(2) elimination by mammalian cells including H(2)O(2) permeation through cytoplasmic and peroxisomal membranes: comparison with experimental data, Biochim. Biophys. Acta 1673 (2004) 149-159.], which includes relevant enzymes and H(2)O(2) permeation through membranes, was found to be fitted well to the H(2)O(2) concentration dependences of removal reaction with the permeation rate constants as variable parameters. As compared with PC12 cells as a culture model for neuron, H(2)O(2) removal activity of astrocytes was considerably higher at physiological H(2)O(2) concentrations. The details of the mathematical model are presented in Appendix.

  8. Chloroquine Inhibits Dengue Virus Type 2 Replication in Vero Cells but Not in C6/36 Cells

    Kleber Juvenal Silva Farias

    2013-01-01

    Full Text Available Dengue viruses are the most important arthropod-borne viruses in terms of morbidity and mortality in the world. Since there is no dengue vaccine available for human use, we have set out to investigate the use of chloroquine as an antiviral drug against dengue. Chloroquine, an amine acidotropic drug known to affect intracellular exocytic pathways by increasing endosomal pH, was used in the in vitro treatment of Vero and C6/36 cells infected with dengue virus type 2 (DENV-2. Real-time RT-PCR and plaque assays were used to quantify the DENV-2 load in infected Vero and C6/36 cells after chloroquine treatment. Our results showed that a dose of 50 μg/ml of chloroquine was not toxic to the cells and induced a statistically significant inhibition of virus production in infected Vero cells when compared to untreated cells. In C6/36 cells, chloroquine does not induce a statistically significant difference in viral replication when compared to untreated cells, showing that this virus uses an unlikely pathway of penetration in these cells, and results were also confirmed by the plaque assay (PFU. These data suggest that the inhibition of virus infection induced by chloroquine is due to interference with acidic vesicles in mammalian cells.

  9. Chloroquine inhibits dengue virus type 2 replication in Vero cells but not in C6/36 cells.

    Farias, Kleber Juvenal Silva; Machado, Paula Renata Lima; da Fonseca, Benedito Antônio Lopes

    2013-01-01

    Dengue viruses are the most important arthropod-borne viruses in terms of morbidity and mortality in the world. Since there is no dengue vaccine available for human use, we have set out to investigate the use of chloroquine as an antiviral drug against dengue. Chloroquine, an amine acidotropic drug known to affect intracellular exocytic pathways by increasing endosomal pH, was used in the in vitro treatment of Vero and C6/36 cells infected with dengue virus type 2 (DENV-2). Real-time RT-PCR and plaque assays were used to quantify the DENV-2 load in infected Vero and C6/36 cells after chloroquine treatment. Our results showed that a dose of 50 μg/ml of chloroquine was not toxic to the cells and induced a statistically significant inhibition of virus production in infected Vero cells when compared to untreated cells. In C6/36 cells, chloroquine does not induce a statistically significant difference in viral replication when compared to untreated cells, showing that this virus uses an unlikely pathway of penetration in these cells, and results were also confirmed by the plaque assay (PFU). These data suggest that the inhibition of virus infection induced by chloroquine is due to interference with acidic vesicles in mammalian cells.

  10. Hydroxyl radical yields in the tracks of high energy 13C6+ and 36Ar18+ ions in liquid water

    Baldacchino, G.; Vigneron, G.; Renault, J.P.; Le Caer, S.; Pin, S.; Mialocq, J.-C.; Balanzat, E.; Bouffard, S.

    2006-01-01

    This article reports the determination of the OH · radiolytic yields in water irradiated by high energy C 6+ and Ar 18+ ions with LET values of 32 ± 2 and 280 ± 10 eV nm -1 . The time evolution of the yields between 9 x 10 -11 and 9 x 10 -8 s was deduced using the scavenging method with SCN - and Br - and pulse radiolysis with pulses of 5 and 10 μs. The thiocyanate chemical system is less affected with the local high dose rates specific to the high LET particles than the bromide system. At 32 eV nm -1 with C 6+ ions, G(OH · ) reaches a maximum of 1.5 x 10 -7 mol J -1 at 1 ns and decreases at earlier times. With Ar 18+ ions of 280 eV nm -1 G(OH · ) is always increasing at early times up to 1.6 x 10 -7 mol J -1 at 9 x 10 -11 s. In this case the evolution of the hydroxyl radical yields agrees with the high local concentrations obtained with Ar 18+ and C 6+ ions and depicted in recent literature with the yields of the hydrated electron in the ns range

  11. Topologically guided tuning of Zr-MOF pore structures for highly selective separation of C6 alkane isomers

    Wang, Hao

    2018-04-25

    As an alternative technology to energy intensive distillations, adsorptive separation by porous solids offers lower energy cost and higher efficiency. Herein we report a topology-directed design and synthesis of a series of Zr-based metal-organic frameworks with optimized pore structure for efficient separation of C6 alkane isomers, a critical step in the petroleum refining process to produce gasoline with high octane rating. Zr6O4(OH)4(bptc)3 adsorbs a large amount of n-hexane but excluding branched isomers. The n-hexane uptake is ~70% higher than that of a benchmark adsorbent, zeolite-5A. A derivative structure, Zr6O4(OH)8(H2O)4(abtc)2, is capable of discriminating all three C6 isomers and yielding a high separation factor for 3-methylpentane over 2,3-dimethylbutane. This property is critical for producing gasoline with further improved quality. Multicomponent breakthrough experiments provide a quantitative measure of the capability of these materials for separation of C6 alkane isomers. A detailed structural analysis reveals the unique topology, connectivity and relationship of these compounds.

  12. Stability of nano-fluids and their use for thermal management of a microprocessor: an experimental and numerical study

    Shoukat, Ahmad Adnan; Shaban, Muhammad; Israr, Asif; Shah, Owaisur Rahman; Khan, Muhammad Zubair; Anwar, Muhammad

    2018-03-01

    We investigate the heat transfer effect of different types of Nano-fluids on the pin fin heat sinks used in computer's microprocessor. Nano-particles of Aluminum oxide have been used with volumetric concentrations of 0.002% and Silver oxide with volumetric concentrations of 0.001% in the base fluid of deionized water. We have also used Aluminum oxide with ethylene glycol at volumetric concentrations of 0.002%. We report the cooling rates of Nano-fluids for pin-fin heat to cool the microprocessor and compare these with the cooling rate of pure water. We use a microprocessor heat generator in this investigation. The base temperature is obtained using surface heater of power 130 W. The main purpose of this work is to minimize the base temperature, and increase the heat transfer rate of the water block and radiator. The temperature of the heat sink is maintained at 110 °C which is nearly equal to the observed computer microprocessor temperature. We also provide the base temperature at different Reynolds's number using the above mention Nano-fluids with different volumetric concentrations.

  13. A microprocessor-based system for continuous monitoring of radiation levels around the CERN PS and PSB accelerators

    Agoritsas, V.; Beck, F.; Benincasa, G. P.; Bovigny, J. P.

    1986-06-01

    This paper describes a new beam loss monitor system which has been installed in the PS and PSB machines, replacing an earlier system. The new system is controlled by a microprocessor which can operate independently of the accelerator control system, though setting up and central display are usually done remotely, using the standard control system facilities.

  14. Microprocessor-based system for continuous monitoring of radiation levels around the CERN PS and PSB accelerators

    Agoritsas, V.; Beck, F.; Benincasa, G.P.; Bovigny, J.P.

    1986-06-01

    This paper describes a new beam loss monitor system which has been installed in the PS and PSB machines, replacing an earlier system. The new system is controlled by a microprocessor which can operate independently of the accelerator control system, though setting up and central display are usually done remotely, using the standard control system facilities.

  15. Synthesis of aryl b-N-acetylglucosamine desmodified at C-6 as potential antimicrobial agents; Sintese de b-N-acetilglicosaminideos de arila modificados em C-6 como potenciais agentes antimicrobianos

    Manfrini, Rozangela Magalhaes; Souza Filho, Jose Dias de [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Inst. de Ciencias Exatas; Figueireido, Rute Cunha; D' Angelis, Allison Fabiano; Prado, Maria Auxiliadora Fontes; Nunan, Elziria de Aguiar; Martins, Gabriela Aires; Alves, Ricardo Jose [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Faculdade de Farmacia. Dept. de Produtos Farmaceuticos]. E-mail: ricardodylan@farmacia.ufmg.br

    2008-07-01

    We report herein the synthesis of aryl beta-N-acetylglucosaminides containing azido, amino and acetamido groups at C-6 as potential antimicrobial agents. It was expected that these compounds could interfere with the biosynthesis and/or biotransformation of Nacetylglucosamine in fungi and bacteria. None of the compounds showed antimicrobial activity against bacteria (Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa), filamentous fungus (Aspergillus niger) and yeasts (Saccharomyces cerevisae, Candida albicans and Candida tropicallis), at the concentration of 1 mg/mL in agar diffusion assay. (author)

  16. Advanced Transport Operating System (ATOPS) color displays software description microprocessor system

    Slominski, Christopher J.; Plyler, Valerie E.; Dickson, Richard W.

    1992-01-01

    This document describes the software created for the Sperry Microprocessor Color Display System used for the Advanced Transport Operating Systems (ATOPS) project on the Transport Systems Research Vehicle (TSRV). The software delivery known as the 'baseline display system', is the one described in this document. Throughout this publication, module descriptions are presented in a standardized format which contains module purpose, calling sequence, detailed description, and global references. The global reference section includes procedures and common variables referenced by a particular module. The system described supports the Research Flight Deck (RFD) of the TSRV. The RFD contains eight cathode ray tubes (CRTs) which depict a Primary Flight Display, Navigation Display, System Warning Display, Takeoff Performance Monitoring System Display, and Engine Display.

  17. Automated microprocessor-controlled atomic absorption analysis of natural water for arsenic and selenium

    Morrow, R.W.; Futrell, T.L.; Adams, T.T.

    1978-08-01

    An automated, dual-channel atomic absorption spectrophotometer for the simultaneous determination of arsenic and selenium in natural water is now in operation. The instrument was constructed from commercially available optical components, spectral sources, and a sample changer. Automation was achieved by using an in-house-fabricated and programmed microprocessor. The instrument will analyze samples at a rate of 37 per hour, and a quantitative determination of arsenic and selenium to 0.2 μg/l (ppB) can be achieved. Arsenic can be determined with a precision of 19% at 1 μg/l and 6% at 10 μg/l, while selenium can be determined with a precision of 17% at 1 μg/l and 4% at 10 μg/l

  18. Portable regional cerebral blood flow system based on IBM PC/AT and microprocessor electronics

    Mun, S.K.; Mun, I.K.; Petite, J.; Cohan, S.L.; Fahey, F.H.

    1986-01-01

    A portable 16-channel reginal cerebral blood flow (rCBF) measuring system has been developed using an IBM PC/AT and new microelectronics to improve processing speed and portability. The detector electronics were developed by Scan Detectronics A/S of Denmark. The counter module contains 18 16-bit counters, each programmable in four different modes. The rate meter has three independent microprocessor controllers for rate meter functions, window controller, and channel controller. The detector electronics and detection parameters can be fully controlled by the host PC/AT. The menu-driven system (Better Basic) assists the operator at each step. The collected data from 16 channels can be processed automatically or postprocessed using more flexible and sophisticated techniques within 20 minutes. The headgear holding 16 sodium iodide detectors is fabricated by modifying a motorcycle helmet

  19. Microprocessor-based, on-line decision aid for resolving conflicting nuclear reactor instrumentation

    Alesso, H.P.

    1981-01-01

    We describe one design for a microprocessor-based, on-line decision aid for identifying and resolving false, conflicting, or misleading instrument indications resulting from certain systems interactions for a pressurized water reactor. The system processes sensor signals from groups of instruments that track together under nominal transient and certain accident conditions, and alarms when they do not track together. We examine multiple-casualty systems interaction and formulate a trial grouping of variables that track together under specified conditions. A two-of-three type redundancy check of key variables provides alarm and indication of conflicting information when one signal suddenly tracks in opposition due to multiple casualty, instrument failure, and/or locally abnormal conditions. Since a vote count of two of three variables in conflict as inconclusive evidence, the system is not designed to provide tripping or corrective action, but improves the operator/instrument interface by providing additional and partially digested information

  20. Microprocessor based beam intensity and efficiency display system for the Fermilab accelerator

    Biwer, R.

    1979-01-01

    The Main Accelerator display system for the Fermilab accelerator gathers charge data and displays it including processed transfer efficiencies of each of the accelerators. To accomplish this, strategically located charge converters monitor the circulating internal beam of each of the Fermilab accelerators. Their outputs are processed via an asynchronously triggered, multiplexed analog-to-digital converter. The data is converted into a digital byte containing address code and data, then stores it into two 16-bit memories. One memory outputs the interleaved data as a data pulse train while the other interfaces directly to a local host computer for further analysis. The microprocessor based display unit synchronizes displayed data during normal operation as well as special storage modes. The display unit outputs data to the fron panel in the form of a numeric value and also makes digital-to-analog conversions of displayed data for external peripheral devices. 5 refs

  1. Experience in the installation of a microprocessor system for controlling converter units of the Vyborg substation

    Gusakovskii, K. B.; Zmaznov, E. Yu.; Katantsev, S. V.; Mazurenko, A. K.; Mestergazi, V. A.; Prochan, G. G.; Funtikova, S. F.

    2006-01-01

    The experience in the installation of modern digital systems for controlling converter units at the Vyborg converter substation on the basis of advanced microprocessor devices is considered. It is shown that debugging of a control and protection system on mathematical and physical models does not guarantee optimum control of actual converter devices. Examples of advancing the control and protection system are described, the necessity for which has become obvious in tests of actual equipment. Comparison of oscillograms of processes before optimization of the control system and after its optimization and adjustment shows that the digital control system makes it possible to improve substantially the algorithms of control and protection in the short term and without changing the hardware component

  2. Guidelines for design and development of computer/microprocessor based systems in research and power reactors

    Dhodapkar, S.D.; Chandra, A.K.

    1993-01-01

    Computer systems are being used in Indian research reactors and nuclear power plants in the areas of data acquisition, process monitoring and control, alarm annunciation and safety. The design and evaluation of these systems requires a special approach particularly due to the unique nature of the software which is an essential constituent of these systems. It was decided to evolve guidelines for designing and review of computer/microprocessor based systems for use in nuclear power plants in India. The present document tries to address various issues and presents guidelines which are as comprehensive as possible and cover all issues relating to the design and development of computer based systems. These guidelines are expected to be useful to the specifiers, designers and reviewers of such systems. (author). 6 refs., 1 fig

  3. A microprocessor based monitoring system for a small nuclear reactor facility

    Miller, G.E.; DeKeyser, C.F.

    1980-01-01

    An inexpensive microprocessor based system has been designed and constructed for our 250 kilowatt TRIGA reactor facility. The system, which is beginning operational testing, can monitor on a continuous basis the status of up to 54 devices and maintain a record of events. These devices include fixed radiation monitors, pool water level trips, security alarms and an access control unit. In the latter case, the unit permits selection of different levels of access permission based on the time of day. The system can alert security and other personnel in the event of abnormalities. Because of the inclusion of this in the security system, special reliability and failure mode operation. The unit must also be simple to install, program and operate. (author)

  4. System and method for leveraging human physiological traits to control microprocessor frequency

    Shye, Alex; Pan, Yan; Scholbrock, Benjamin; Miller, J. Scott; Memik, Gokhan; Dinda, Peter A; Dick, Robert P

    2014-03-25

    A system and method for leveraging physiological traits to control microprocessor frequency are disclosed. In some embodiments, the system and method may optimize, for example, a particular processor-based architecture based on, for example, end user satisfaction. In some embodiments, the system and method may determine, for example, whether their users are satisfied to provide higher efficiency, improved reliability, reduced power consumption, increased security, and a better user experience. The system and method may use, for example, biometric input devices to provide information about a user's physiological traits to a computer system. Biometric input devices may include, for example, one or more of the following: an eye tracker, a galvanic skin response sensor, and/or a force sensor.

  5. A technique of building a value function at the stage of conceptual design of microprocessor systems

    B. N. Chugaev

    2017-01-01

    Full Text Available The aim of this study is to formalize the selection of optimal technical solutions early in the design of microprocessor-based systems, which allows developers to analyze the recommended solutions, and has, in comparison with the traditional «intuitive» approach, at least two undeniable merits. First, the accepted assumptions and limitations are clearly formed. Secondly, it is defined precisely, in what sense the decision is optimal. When designing microprocessor systems (systems hereafter, several characteristics have to be taken into account at the same time. In general, when n properties are taken into account for each of the compared systems, then the solution of the task of choosing “the best” system depends on choosing a function-criterion. Such function is called a value function in the article. A simple quadratic function is suggested as the value function, it can be interpreted as the distance in Euclidean space of systems technical data. The system, which corresponds to the point nearest to the point characterizing the master system with “limiting” characteristics, is considered the best one. This function approximates the designer’s system of preferences signifi cantly better than a “classical” linear value function. In conclusion, note that the developed recommendations allow the designer of complex technical systems to analyze the proposed solutions in the early stages of design and, in case of disagreement with them, to indicate the reasons why he considers them inadequate. The designed machine optimization of technical solutions in conjunction with the traditional engineering approach should allow more reasonable choosing the structure of systems at the stage of systems conceptual design.

  6. Thermal treatment system of hazardous residuals in three heating zones based on a microprocessor

    Luna H, C.L.

    1997-01-01

    Thermal treatment system consists of a high power electric oven of three heating zones where each zone works up to 1200 Centigrades; it has the capacity of rising the central zone temperature up to 1000 Centigrades in 58 minutes approximately. This configuration of three zones could be programmed to different temperatures and they will be digitally controlled by a control microprocessor, which has been controlled by its own assembler language, in function of the PID control. There are also other important controls based on this microprocessor, as a signal amplification, starting and shutdown of high power step relays, activation and deactivation of both analogic/digital and digital/analogic convertors, port activation and basic data storage of the system. Two main characteristics were looked for this oven design; the first was the possibility of controlling the three zone temperature and the second was to reduce the rising and stabilization operation time and its digitized control. The principal function of the three zone oven is to accelerate the degradation of hazardous residuals by an oxidation instead combustion, through relatively high temperatures (minimum 800 Centigrades and maximum 1200 Centigrades); this process reduces the ash and volatile particulate production. The hazardous residuals will be pumped into the degradation system and after atomized through a packaged column; this step will avoid the direct contact of the residuals with the oven cores. These features make this system as closed process, which means that the residuals can not leak to the working area, reducing the exposure risk to the personnel. This three step oven system is the first stage of the complete hazardous residuals degradation system; after this, the flow will go into a cold plasma region where the process is completed, making a closed system. (Author)

  7. Immediate effects of a new microprocessor-controlled prosthetic knee joint: a comparative biomechanical evaluation.

    Bellmann, Malte; Schmalz, Thomas; Ludwigs, Eva; Blumentritt, Siegmar

    2012-03-01

    To investigate the immediate biomechanical effects after transition to a new microprocessor-controlled prosthetic knee joint. Intervention cross-over study with repeated measures. Only prosthetic knee joints were changed. Motion analysis laboratory. Men (N=11; mean age ± SD, 36.7±10.2y; Medicare functional classification level, 3-4) with unilateral transfemoral amputation. Two microprocessor-controlled prosthetic knee joints: C-Leg and a new prosthetic knee joint, Genium. Static prosthetic alignment, time-distance parameters, kinematic and kinetic parameters, and center of pressure. After a half-day training and an additional half-day accommodation, improved biomechanical outcomes were demonstrated by the Genium: lower ground reaction forces at weight acceptance during level walking at various velocities, increased swing phase flexion angles during walking on a ramp, and level walking with small steps. Maximum knee flexion angle during swing phase at various velocities was nearly equal for Genium. Step-over-step stair ascent with the Genium knee was more physiologic as demonstrated by a more equal load distribution between the prosthetic and contralateral sides and a more natural gait pattern. When descending stairs and ramps, knee flexion moments with the Genium tended to increase. During quiet stance on a decline, subjects using Genium accepted higher loading of the prosthetic side knee joint, thus reducing same side hip joint loading as well as postural sway. In comparision to the C-Leg, the Genium demonstrated immediate biomechanical advantages during various daily ambulatory activities, which may lead to an increase in range and diversity of activity of people with above-knee amputations. Results showed that use of the Genium facilitated more natural gait biomechanics and load distribution throughout the affected and sound musculoskeletal structure. This was observed during quiet stance on a decline, walking on level ground, and walking up and down ramps and

  8. Dopamine induces growth inhibition and vascular normalization through reprogramming M2-polarized macrophages in rat C6 glioma

    Qin, Tian; Wang, Chenlong; Chen, Xuewei; Duan, Chenfan; Zhang, Xiaoyan; Zhang, Jing; Chai, Hongyan; Tang, Tian; Chen, Honglei; Yue, Jiang; Li, Ying; Yang, Jing

    2015-01-01

    Dopamine (DA), a monoamine catecholamine neurotransmitter with antiangiogenic activity, stabilizes tumor vessels in colon, prostate and ovarian cancers, thus increases chemotherapeutic efficacy. Here, in the rat C6 glioma models, we investigated the vascular normalization effects of DA and its mechanisms of action. DA (25, 50 mg/kg) inhibited tumor growth, while a precursor of DA (levodopa) prolonged the survival time of rats bearing orthotopic C6 glioma. DA improved tumor perfusion, with significant effects from day 3, and a higher level at days 5 to 7. In addition, DA decreased microvessel density and hypoxia-inducible factor-1α expression in tumor tissues, while increasing the coverage of pericyte. Conversely, an antagonist of dopamine receptor 2 (DR2) (eticlopride) but not DR1 (butaclamol) abrogated DA-induced tumor regression and vascular normalization. Furthermore, DA improved the delivery and efficacy of temozolomide therapy. Importantly, DA increased representative M1 markers (iNOS, CXCL9, etc.), while decreasing M2 markers (CD206, arginase-1, etc.). Depletion of macrophages by clodronate or zoledronic acid attenuated the effects of DA. Notably, DA treatment induced M2-to-M1 polarization in RAW264.7 cells and mouse peritoneal macrophages, and enhanced the migration of pericyte-like cells (10T1/2), which was reversed by eticlopride or DR2-siRNA. Such changes were accompanied by the downregulation of VEGF/VEGFR2 signaling. In summary, DA induces growth inhibition and vascular normalization through reprogramming M2-polarized macrophages. Thus, targeting the tumor microvasculature by DA represents a promising strategy for human glioma therapy. - Highlights: • Dopamine induces tumor growth inhibition and vascular normalization in rat C6 glioma. • Dopamine switches macrophage phenotype from M2 to M1. • Dopamine-induced vascular normalization is mediated by macrophage polarization. • Dopamine is a promising agent targeting the microvasculature in tumor

  9. Dopamine induces growth inhibition and vascular normalization through reprogramming M2-polarized macrophages in rat C6 glioma

    Qin, Tian; Wang, Chenlong; Chen, Xuewei; Duan, Chenfan; Zhang, Xiaoyan [Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071 (China); Zhang, Jing [Animal Experimental Center of Wuhan University, Wuhan 430071 (China); Chai, Hongyan [Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University, Wuhan 430071 (China); Tang, Tian [Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060 (China); Chen, Honglei [Department of Pathology and Pathophysiology, School of Medicine, Wuhan University, Wuhan 430071 (China); Yue, Jiang [Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071 (China); Li, Ying, E-mail: lyying0@163.com [Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071 (China); Yang, Jing, E-mail: yangjingliu2013@163.com [Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071 (China)

    2015-07-15

    Dopamine (DA), a monoamine catecholamine neurotransmitter with antiangiogenic activity, stabilizes tumor vessels in colon, prostate and ovarian cancers, thus increases chemotherapeutic efficacy. Here, in the rat C6 glioma models, we investigated the vascular normalization effects of DA and its mechanisms of action. DA (25, 50 mg/kg) inhibited tumor growth, while a precursor of DA (levodopa) prolonged the survival time of rats bearing orthotopic C6 glioma. DA improved tumor perfusion, with significant effects from day 3, and a higher level at days 5 to 7. In addition, DA decreased microvessel density and hypoxia-inducible factor-1α expression in tumor tissues, while increasing the coverage of pericyte. Conversely, an antagonist of dopamine receptor 2 (DR2) (eticlopride) but not DR1 (butaclamol) abrogated DA-induced tumor regression and vascular normalization. Furthermore, DA improved the delivery and efficacy of temozolomide therapy. Importantly, DA increased representative M1 markers (iNOS, CXCL9, etc.), while decreasing M2 markers (CD206, arginase-1, etc.). Depletion of macrophages by clodronate or zoledronic acid attenuated the effects of DA. Notably, DA treatment induced M2-to-M1 polarization in RAW264.7 cells and mouse peritoneal macrophages, and enhanced the migration of pericyte-like cells (10T1/2), which was reversed by eticlopride or DR2-siRNA. Such changes were accompanied by the downregulation of VEGF/VEGFR2 signaling. In summary, DA induces growth inhibition and vascular normalization through reprogramming M2-polarized macrophages. Thus, targeting the tumor microvasculature by DA represents a promising strategy for human glioma therapy. - Highlights: • Dopamine induces tumor growth inhibition and vascular normalization in rat C6 glioma. • Dopamine switches macrophage phenotype from M2 to M1. • Dopamine-induced vascular normalization is mediated by macrophage polarization. • Dopamine is a promising agent targeting the microvasculature in tumor

  10. Microwave-assisted solid phase conversion study of Meldrum's acid to ethylenetetracarboxylic dianhydride (C 6O 6)

    Taherpour, Avat (Arman)

    2010-01-01

    Utilization of microwave irradiation provides an effective method for fast synthesizing of some important compounds. Microwave-assisted solid phase is an especial class in chemical synthesis. By the use of MW-irradiation on chemicals, sometimes interesting results can be seen. The synthesis of the interesting molecule ethylenetetracarboxylic dianhydride (C 6O 6) was attempted with a few different methods. In this study, the microwave-assisted solid phase conversion of Meldrum's acid to ethylenetetracarboxylic dianhydride was reported. This conversion was characterized by FT-IR, GC/MS and NMR spectroscopy results.

  11. Precalculation of the fission gas behaviour in the MOL 7C/6 experiment with the LAKU model

    Vaeth, L.

    1988-03-01

    The fission gas behaviour in the planned experiment MOL 7C/6 is simulated with the Karlsruhe model LAKU, employing temperatures calculated with the pin behaviour model TRANSURANUS. Two different modes of experimental flow blockage simulation are investigated and compared to an estimated fission gas behaviour during a realistic blockage build-up. The results indicate, that the start-up procedure leading to greatly reduced fission gas content is the more realistic one. Details of the calculations and their results are presented in the report

  12. ORIGIN FOR IRRADIATION EFFECT OF 0.56GeV C6+ ON CaVSn:YIG

    熊宏齐; 侯明东; 等

    1995-01-01

    This paper presents numerous physical characteristics of Ca,V.Sn doped yttrium iron garnet(CaVSn:YIG) irradiated with 0.56GeV carbon ions delivered by the Heavy Ion Research Facility of Lanzhou (HIRFL).The reason for change of the magnetic properties of the samples induced by energetic carbon ions bombardment is discussed.By comparison of this results with the irradiation effects of YIG induced by eneregetic argon,krypton and xenon oibtained on the GANIL,Caen,France,it is concluded that the irradiation effect of 0.56GeV C6+ on CaVSn:YIG arises from the electronic energy losses.

  13. Determination of C6-C10 aromatic hydrocarbons in water by purge-and-trap capillary gas chromatography

    Eganhouse, R.P.; Dorsey, T.F.; Phinney, C.S.; Westcott, A.M.

    1993-01-01

    A method is described for the determination of the C6-C10 aromatic hydrocarbons in water based on purge-and-trap capillary gas chromatography with flame ionization and mass spectrometric detection. Retention time data and 70 eV mass spectra were obtained for benzene and all 35 C7-C10 aromatic hydrocarbons. With optimized chromatographic conditions and mass spectrometric detection, benzene and 33 of the 35 alkylbenzenes can be identified and measured in a 45-min run. Use of a flame ionization detector permits the simultaneous determination of benzene and 26 alkylbenzenes.

  14. Chloroquine Inhibits Dengue Virus Type 2 Replication in Vero Cells but Not in C6/36 Cells

    Farias, Kleber Juvenal Silva; Machado, Paula Renata Lima; da Fonseca, Benedito Antônio Lopes

    2013-01-01

    Dengue viruses are the most important arthropod-borne viruses in terms of morbidity and mortality in the world. Since there is no dengue vaccine available for human use, we have set out to investigate the use of chloroquine as an antiviral drug against dengue. Chloroquine, an amine acidotropic drug known to affect intracellular exocytic pathways by increasing endosomal pH, was used in the in vitro treatment of Vero and C6/36 cells infected with dengue virus type 2 (DENV-2). Real-time RT-PCR a...

  15. Intracellular labeling and quantification process by magnetic resonance imaging using iron oxide magnetic nanoparticles in rat C6 glioma cell line; Marcacao intracelular e processo de quantificacao por imagem por ressonancia magnetica utilizando nanoparticulas magneticas de oxido de ferro em celulas da linhagem C6 de glioma de rato

    Mamani, Javier Bustamante; Pavon, Lorena Favaro; Sibov, Tatiana Tais; Rossan, Fabiana; Silveira, Paulo Henrique; Cardenas, Walter Humberto; Gamarra, Lionel Fernel, E-mail: javierbm@einstein.br [Instituto do Cerebro - InCe, Hospital Israelita Albert Einstein - HIAE, Sao Paulo, SP (Brazil); Miyaki, Liza Aya Mabuchi [Faculdade de Enfermagem, Hospital Israelita Albert Einstein - HIAE, Sao Paulo, SP (Brazil); Amaro Junior, Edson [Departamento de Diagnostico por Imagem e Instituto do Cerebro - InCe, Hospital Israelita Albert Einstein - HIAE, Sao Paulo, SP (Brazil)

    2012-04-15

    Objective: To assess intracellular labeling and quantification by magnetic resonance imaging using iron oxide magnetic nanoparticles coated with biocompatible materials in rat C6 glioma cells in vitro. These methods will provide direction for future trials of tumor induction in vivo as well as possible magnetic hyperthermia applications. Methods: Aminosilane, dextran, polyvinyl alcohol, and starch-coated magnetic nanoparticles were used in the qualitative assessment of C6 cell labeling via light microscopy. The influence of the transfection agent poly-L-lysine on cellular uptake was examined. The quantification process was performed by relaxometry analysis in T{sub 1} and T{sub 2} weighted phantom images. Results: Light microscopy revealed that the aminosilane-coated magnetic nanoparticles alone or complexed with poly-L-lysine showed higher cellular uptake than did the uncoated magnetic particles. The relaxactivities of the aminosilane-coated magnetic nanoparticles with a hydrodynamic diameter of 50nm to a 3-T field were r{sub 1}=(6.1 +- 0.3) x10{sup -5} ms{sup -1}mL/{mu}g, r{sub 2}=(5.3 +- 0.1) x 10{sup -4} ms{sup -1}mL/{mu}g, with a ratio of r{sub 2} / r{sub 1}{approx_equal} 9. The iron uptake in the cells was calculated by analyzing the relaxation rates (R{sub 1}and R{sub 2}) using a mathematical relationship. Conclusions: C6 glioma cells have a high uptake efficiency for aminosilane-coated magnetic nanoparticles complexed with the transfection agent poly-L-lysine. The large ratio r{sub 2} / r{sub 1}{approx_equal} 9 indicates that these magnetic nanoparticles are ideal for quantification by magnetic resonance imaging with T{sub 2}-weighted imaging techniques. (author)

  16. The pro1(+) gene from Sordaria macrospora encodes a C6 zinc finger transcription factor required for fruiting body development.

    Masloff, S; Pöggeler, S; Kück, U

    1999-05-01

    During sexual morphogenesis, the filamentous ascomycete Sordaria macrospora differentiates into multicellular fruiting bodies called perithecia. Previously it has been shown that this developmental process is under polygenic control. To further understand the molecular mechanisms involved in fruiting body formation, we generated the protoperithecia forming mutant pro1, in which the normal development of protoperithecia into perithecia has been disrupted. We succeeded in isolating a cosmid clone from an indexed cosmid library, which was able to complement the pro1(-) mutation. Deletion analysis, followed by DNA sequencing, subsequently demonstrated that fertility was restored to the pro1 mutant by an open reading frame encoding a 689-amino-acid polypeptide, which we named PRO1. A region from this polypeptide shares significant homology with the DNA-binding domains found in fungal C6 zinc finger transcription factors, such as the GAL4 protein from yeast. However, other typical regions of C6 zinc finger proteins, such as dimerization elements, are absent in PRO1. The involvement of the pro1(+) gene in fruiting body development was further confirmed by trying to complement the mutant phenotype with in vitro mutagenized and truncated versions of the pro1 open reading frame. Southern hybridization experiments also indicated that pro1(+) homologues are present in other sexually propagating filamentous ascomycetes.

  17. Rapid and sensitive quantification of C3- and C6-phosphoesters in starch by fluorescence-assisted capillary electrophoresis.

    Verbeke, Jeremy; Penverne, Christophe; D'Hulst, Christophe; Rolando, Christian; Szydlowski, Nicolas

    2016-11-05

    Phosphate groups are naturally present in starch at C3- or C6-position of the glucose residues and impact the structure of starch granules. Their precise quantification is necessary for understanding starch physicochemical properties and metabolism. Nevertheless, reliable quantification of Glc-3-P remains laborious and time consuming. Here we describe a capillary electrophoresis method for simultaneous measurement of both Glc-6-P and Glc-3-P after acid hydrolysis of starch. The sensitivity threshold was estimated at the fg scale, which is compatible with the analysis of less than a μg of sample. The method was validated by analyzing antisense potato lines deficient in SBEs, GWD or GBSS. We show that Glc-3-P content is altered in the latter and that these variations do not correlate with modifications in Glc-6-P content. We anticipate the method reported here to be an efficient tool for high throughput study of starch phosphorylation at both C3- and C6-position. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. ROS enhancement by silicon nanoparticles in X-ray irradiated aqueous suspensions and in glioma C6 cells

    David Gara, Pedro M.; Garabano, Natalia I.; Llansola Portoles, Manuel J.; Moreno, M. Sergio; Dodat, Diego; Casas, Oscar R.; Gonzalez, Mónica C.; Kotler, Mónica L.

    2012-01-01

    The capability of silicon nanoparticles to increase the yield of reactive species upon 4 MeV X-ray irradiation of aqueous suspensions and C6 glioma cell cultures was investigated. ROS generation was detected and quantified using several specific probes. The particles were characterized by FTIR, XPS, TEM, DLS, luminescence, and adsorption spectroscopy before and after irradiation to evaluate the effect of high energy radiation on their structure. The total concentration of O 2 •− /HO 2 • , HO • , and H 2 O 2 generated upon 4-MeV X-ray irradiation of 6.4 μM silicon nanoparticle aqueous suspensions were on the order of 10 μM per Gy, ten times higher than that obtained in similar experiments but in the absence of particles. Cytotoxic 1 O 2 was generated only in irradiation experiments containing the particles. The particle surface became oxidized to SiO 2 and the luminescence yield reduced with the irradiation dose. Changes in the surface morphology did not affect, within the experimental error, the yields of ROS generated per Gy. X-ray irradiation of glioma C6 cell cultures with incorporated silicon nanoparticles showed a marked production of ROS proportional to the radiation dose received. In the absence of nanoparticles, the cells showed no irradiation-enhanced ROS generation. The obtained results indicate that silicon nanoparticles of 1 O 2 upon X-ray irradiation opens novel approaches in the design of therapy strategies.

  19. Induction of P450 3A1/2 and 2C6 by gemfibrozil in Sprague-Dawley rats.

    Liu, Aiming; Yang, Julin; Zhao, Xin; Jiao, Xiaolan; Zhao, Weihong; Ma, Qing; Tang, Zhiyuan; Dai, Renke

    2011-01-01

    Fibrates are a group of peroxisome proliferator-activated receptor α agonists used in the treatment of dyslipidemia; however, they have been reported to cause species-related hepatocarcinogenesis and clinical myotoxicity. Gemfibrozil is one of the most commonly used fibrates, and it shows the highest risk for myotoxicity among the fibrates. The inhibitory drug-drug interaction mechanism associated with gemfibrozil has been explored recently, and the induction of human P450 3A4 and 2C8 has been reported. In this study, in vivo induction of rat P450 by gemfibrozil was studied in Sprague-Dawley rats. After the rats were dosed with gemfibrozil by oral gavage, microsomes were prepared. The metabolic activities of P450 3A1/2, 2C6, and 2D2 were assayed using probe substrates, and the systemic concentration of gemfibrozil during its administration was determined. P450 3A1/2 and 2C6 activities were induced 32-77% in the rats by gemfibrozil when the exposure concentration was in the clinical range. These data indicate that the inducibility of homologous P450 isoforms by gemfibrozil is similar in Sprague-Dawley rats and in humans. Inductive drug-drug interactions and inhibitory actions are involved in the co-administration of gemfibrozil with other drugs, which suggests the relevance for a fibrate-toxicology investigation.

  20. Dentritic Carbosilanes Containing Silicon-Bonded 1-[C6H2(CH2NMe2)2-3,5-Li-4] or 1-[C6H3(CH2NMe2)-4-Li-3] Mono-and Bis(amino)aryllithium End Groups: Structure of {[CH2SiMe2C6H3(CH2NMe2)-4-Li-3]2}2

    Koten, G. van; Kleij, A.W.; Kleijn, H.; Jastrzebski, J.T.B.H.; Smeets, W.J.J.; Spek, A.L.

    1999-01-01

    A useful synthetic procedure for the incorporation of the potentially multidentate monoanionic 1-[C6H2(CH2NMe2)2-3,5]- (=NCN) and 1-[C6H3(CH2NMe2)-4]- (=CN) ligands via the para-position on the periphery of carbosilane (CS) dendrimers has been developed. Lithiation of suitable brominated precursors

  1. The Observation of the Structure of M23C6/ γ Coherent Interface in the 100Mn13 High Carbon High Manganese Steel

    Xu, Zhenfeng; Ding, Zhimin; Liang, Bo

    2018-03-01

    The M23C6 carbides precipitate along the austenite grain boundary in the 100Mn13 high carbon high manganese steel after 1323 K (1050 °C) solution treatment and subsequent 748 K (475 °C) aging treatment. The grain boundary M23C6 carbides not only spread along the grain boundary and into the incoherent austenite grain, but also grow slowly into the coherent austenite grain. On the basis of the research with optical microscope, a further investigation for the M23C6/ γ coherent interface was carried out by transmission electron microscope (TEM). The results show that the grain boundary M23C6 carbides have orientation relationships with only one of the adjacent austenite grains in the same planes: (\\bar{1}1\\bar{1})_{{{M}_{ 2 3} {C}_{ 6} }} //(\\bar{1}1\\bar{1})_{γ } , (\\bar{1}11)_{{{M}_{ 2 3} {C}_{ 6} }} //(\\bar{1}11)_{γ } ,[ 1 10]_{{{M}_{ 2 3} {C}_{ 6} }} //[ 1 10]_{γ } . The flat M23C6/ γ coherent interface lies on the low indexed crystal planes {111}. Moreover, in M23C6/ γ coherent interface, there are embossments which stretch into the coherent austenite grain γ. Dislocations distribute in the embossments and coherent interface frontier. According to the experimental observation, the paper suggests that the embossments can promote the M23C6/ γ coherent interface move. Besides, the present work has analyzed chemical composition of experimental material and the crystal structures of austenite and M23C6, which indicates that the transformation can be completed through a little diffusion for C atoms and a simple variant for austenite unit cell.

  2. Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7.

    Leonie Unterholzner

    2011-09-01

    Full Text Available Recognition of viruses by pattern recognition receptors (PRRs causes interferon-β (IFN-β induction, a key event in the anti-viral innate immune response, and also a target of viral immune evasion. Here the vaccinia virus (VACV protein C6 is identified as an inhibitor of PRR-induced IFN-β expression by a functional screen of select VACV open reading frames expressed individually in mammalian cells. C6 is a member of a family of Bcl-2-like poxvirus proteins, many of which have been shown to inhibit innate immune signalling pathways. PRRs activate both NF-κB and IFN regulatory factors (IRFs to activate the IFN-β promoter induction. Data presented here show that C6 inhibits IRF3 activation and translocation into the nucleus, but does not inhibit NF-κB activation. C6 inhibits IRF3 and IRF7 activation downstream of the kinases TANK binding kinase 1 (TBK1 and IκB kinase-ε (IKKε, which phosphorylate and activate these IRFs. However, C6 does not inhibit TBK1- and IKKε-independent IRF7 activation or the induction of promoters by constitutively active forms of IRF3 or IRF7, indicating that C6 acts at the level of the TBK1/IKKε complex. Consistent with this notion, C6 immunoprecipitated with the TBK1 complex scaffold proteins TANK, SINTBAD and NAP1. C6 is expressed early during infection and is present in both nucleus and cytoplasm. Mutant viruses in which the C6L gene is deleted, or mutated so that the C6 protein is not expressed, replicated normally in cell culture but were attenuated in two in vivo models of infection compared to wild type and revertant controls. Thus C6 contributes to VACV virulence and might do so via the inhibition of PRR-induced activation of IRF3 and IRF7.

  3. Tools for developing software for different types of microprocessors, to be used, in particular, for the acquisition and processing of nuclear data

    Maloeuvre, Michel.

    1982-04-01

    It is difficult to imagine the realization of a system with a microprocessor without the use of an adapted development system. As these systems are prohibitively expensive, it is difficult for a laboratory to acquire them. A computer, such as the Multi 20 is provided with programme generating tools and supervisors to put the computer's ressources at the microprocessor's disposal. An electronic crate assures interface functions with the computer, the emulation of the microprocessor and the loading of EROM and the live memory lank in order to execute the different units integrated into the crate, enables the crate to be used as a portable repair and maintenance outfit for the materials installed. In the first part of the text, we present the principles of the development tools showing how they are used to realize microprocessor equipment. In the second part, the software is optimized together with the choice of materials in order to define a low cost development system [fr

  4. pH dependent green synthesis of gold nanoparticles by completely C6-carboxylated curdlan under high temperature and various pH conditions.

    Qiu, Wen-Yi; Wang, Kai; Wang, Yao-Yao; Ding, Zhi-Chao; Wu, Li-Xia; Cai, Wu-Dan; Yan, Jing-Kun

    2018-01-01

    A C6-carboxylated curdlan (C6-Cc) obtained from 4-acetamido-TEMPO-mediated oxidation of curdlan was used both as a reducing and stabilizing agent for green synthesis of pH-responsive AuNPs, which was carried out by controlling the pH of the C6-Cc solution at a high temperature (100°C). C6-Cc presented a semi-flexible random coil chain in the aqueous medium at pH 5.5 and became more expanded and rigid in alkaline conditions (pH 7.1-12.0), though the primary chemical structure of C6-Cc was virtually unchanged with the pH variation. The AuNPs prepared with C6-Cc at various pHs were characterized by various instrumental measurements. The shapes and sizes of AuNPs were found to be strongly dependent on the pH of the C6-Cc solution. The C6-Cc-decorated AuNPs exhibited a more well-dispersed spherical morphology with smaller particle sizes under alkaline conditions (pH 7.1-12.0). Through this study, a facile, simple, and green method has been demonstrated for preparation of stimuli-sensitive AuNPs using biocompatible polyanionic polysaccharides. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Microencapsulation of a putative probiotic Enterobacter species, C6-6, to protect rainbow trout, Oncorhynchus mykiss (Walbaum), against bacterial coldwater disease.

    Ghosh, B; Cain, K D; Nowak, B F; Bridle, A R

    2016-01-01

    Flavobacterium psychrophilum is the causative agent of bacterial coldwater disease (BCWD), which has a major impact on salmonid aquaculture globally. An Enterobacter species, C6-6, isolated from the gut of rainbow trout, Oncorhynchus mykiss (Walbaum), has been identified as a potential probiotic species providing protection against BCWD. This study examined the effects of alginate microencapsulation on the protective efficacy of C6-6 against BCWD in vivo when administered to rainbow trout fry orally or by intraperitoneal (IP) injection. Viable C6-6 bacteria were microencapsulated successfully, and this process (microencapsulation) did not significantly deteriorate its protective properties as compared to the administration of non-microencapsulated C6-6 bacteria. Both oral and IP delivery of C6-6 achieved significantly better protection than control treatments that did not contain C6-6 bacteria. The highest relative percent survival (RPS) resulted from IP delivery (71.4%) and was significantly greater than the highest oral RPS (38.6%). Successful intestinal colonization was not critical to protective effects of C6-6. The study showed that C6-6 administration, with or without encapsulation, was a viable choice for protecting fry from BCWD especially when administered intraperitoneally. © 2014 John Wiley & Sons Ltd.

  6. Analysis of the Intel 386 and i486 microprocessors for the Space Station Freedom Data Management System

    Liu, Yuan-Kwei

    1991-01-01

    The feasibility is analyzed of upgrading the Intel 386 microprocessor, which has been proposed as the baseline processor for the Space Station Freedom (SSF) Data Management System (DMS), to the more advanced i486 microprocessors. The items compared between the two processors include the instruction set architecture, power consumption, the MIL-STD-883C Class S (Space) qualification schedule, and performance. The advantages of the i486 over the 386 are (1) lower power consumption; and (2) higher floating point performance. The i486 on-chip cache does not have parity check or error detection and correction circuitry. The i486 with on-chip cache disabled, however, has lower integer performance than the 386 without cache, which is the current DMS design choice. Adding cache to the 386/386 DX memory hierachy appears to be the most beneficial change to the current DMS design at this time.

  7. Studies on 2-phenylquinoline Staphylococcus aureus NorA efflux pump inhibitors: New insights on the C-6 position.

    Felicetti, Tommaso; Cannalire, Rolando; Nizi, Maria Giulia; Tabarrini, Oriana; Massari, Serena; Barreca, Maria Letizia; Manfroni, Giuseppe; Schindler, Bryan D; Cecchetti, Violetta; Kaatz, Glenn W; Sabatini, Stefano

    2018-06-06

    The alarming and rapid spread of antimicrobial resistance among bacteria represents a high risk for global health. Targeting factors involved in resistance to restore the activity of failing antibiotics is a promising strategy to overcome this urgent medical need. Efflux pump inhibitors are able to increase antibiotic concentrations in bacteria, thus they can be considered true antimicrobial resistance breakers. In this work, continuing our studies on inhibitors of the Staphylococcus aureus NorA pump, we designed, synthesized and biologically evaluated novel 2-phenylquinoline derivatives starting from our hits 1 and 2. Two of the synthesized compounds (6 and 7) bearing a C-6 benzyloxy group showed the best NorA inhibition activity, thereby providing an excellent starting point to direct future chemical optimizations. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  8. The ANC of 16O subthreshold states from 12C(6Li, d) reaction at energies near the barrier

    Adhikari, Sucheta; Basu, Chinmay

    2011-01-01

    The ANC of the 2 + (6.92 MeV) and 1 - (7.12 MeV) subthreshold states of 16 O have been extracted from the normalization of 12 C( 6 Li, d) angular distribution to a Finite Range Distorted Wave Born Approximation (FRDWBA) calculation. The theoretical analysis indicates a peripheral reaction and the extracted ANCs are not sensitive to the number of nodes in the bound state potential. The uncertainty from the entrance channel potential is minimized to 8% for the 6.92 and 11% for the 7.12 MeV state if the normalization is performed at the grazing angle. The uncertainty from the exit channel potential at the grazing angle is found to be 10% and 12% respectively for the 7.12 and 6.92 MeV states.

  9. Effect of compound nuclear reaction mechanism in 12C(6Li,d) reaction at sub-Coulomb energy

    Mondal, Ashok; Adhikari, S.; Basu, C.

    2017-09-01

    The angular distribution of the 12C(6Li,d) reaction populating the 6.92 and 7.12 MeV states of 16O at sub-Coulomb energy (Ecm=3 MeV) are analysed in the framework of the Distorted Wave Born Approximation (DWBA). Recent results on excitation function measurements and backward angle angular distributions derive ANC for both the states on the basis of an alpha transfer mechanism. In the present work, we show that considering both forward and backward angle data in the analysis, the 7.12 MeV state at sub-Coulomb energy is populated from Compound nuclear process rather than transfer process. The 6.92 MeV state is however produced from direct reaction mechanism.

  10. Conversion of C6 and C5 sugars in undetoxified wet exploded bagasse hydrolysates using Scheffersomyces (Pichia) stipitis CBS6054

    Biswas, Rajib; Uellendahl, Hinrich; Ahring, Birgitte Kiær

    2013-01-01

    Sugarcane bagasse is a potential feedstock for cellulosic ethanol production, rich in both glucan and xylan. This stresses the importance of utilizing both C6 and C5 sugars for conversion into ethanol in order to improve the process economics. During processing of the hydrolysate degradation...... products such as acetate, 5-hydroxymethylfurfural (HMF) and furfural are formed, which are known to inhibit microbial growth at higher concentrations. In the current study, conversion of both glucose and xylose sugars into ethanol in wet exploded bagasse hydrolysates was investigated without detoxification...... using Scheffersomyces (Pichia) stipitis CBS6054, a native xylose utilizing yeast strain. The sugar utilization ratio and ethanol yield (Yp/s) ranged from 88-100% and 0.33-0.41 ± 0.02 g/g, respectively, in all the hydrolysates tested. Hydrolysate after wet explosion at 185°C and 6 bar O2, composed...

  11. A Hiker's guide to K3. Aspects of N=(4,4) superconformal field theory with central charge c=6

    Nahm, W.; Wendland, K.

    2001-01-01

    We study the moduli space M of N=(4,4) superconformal field theories with central charge c=6. After a slight emendation of its global description we find the locations of various known models in the component of M associated to K3 surfaces. Among them are the Z 2 and Z 4 orbifold theories obtained from the torus component of M. Here, SO(4,4) triality is found to play a dominant role. We obtain the B-field values in direction of the exceptional divisors which arise from orbifolding. We prove T-duality for the Z 2 orbifolds and use it to derive the form of M purely within conformal field theory. For the Gepner model (2) 4 and some of its orbifolds we find the locations in M and prove isomorphisms to nonlinear σ models. In particular we prove that the Gepner model (2) 4 has a geometric interpretation with Fermat quartic target space. (orig.)

  12. Nitric oxide donors attenuate clongenic potential in rat C6 glioma cells treated with alkylating chemotherapeutic agents.

    Yang, Jir-Jei; Yin, Jiu-Haw; Yang, Ding-I

    2007-05-11

    1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) kills tumor cells via multiple actions including alkylation and carbamoylation. Previously, we have reported that formation of S-nitrosoglutathione (GSNO) in glioma cells overexpressing inducible nitric oxide synthase (iNOS) contributed to nitric oxide (NO)-dependent carbamoylating chemoresistance against BCNU. To further characterize the effects of NO on alkylating cytotoxicity, colony formation assay was applied to evaluate the effects of various NO donors on rat C6 glioma cells challenged with alkylating agents. We demonstrate that NO donors including GSNO, diethylamine NONOate (DEA/NO), and sodium nitroprusside (SNP) substantially reduced the extent of colony formation in glioma cells treated with alkylating agents, namely methyl methanesulfonate (MMS), N-methyl-N-nitrosourea (MNU), and N-ethyl-N-nitrosourea (ENU). Without alkylating agents these NO-releasing agents alone had no effects on clongenic potential of rat C6 glioma cells. Among these three NO donors used, the effectiveness in potentiating alkylating cytotoxicity is in the order of "GSNO>DEA/NO>SNP" when applied at the same dosages. GSNO also exerted similar synergistic actions reducing the extents of colony formation when co-administrated with 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-hydrazine (compound #1), another alkylating agent that mimics the chloroethylating action of BCNU. Together with our previous findings, we propose that NO donors may be used as adjunct chemotherapy with alkylating agents for such malignant brain tumors as glioblastoma multiforme (GBM). In contrast, production of NO as a result of iNOS induction, such as that occurring after surgical resection of brain tumors, may compromise the efficacy of carbamoylating chemotherapy.

  13. Infection of Mosquito Cells (C6/36) by Dengue-2 Virus Interferes with Subsequent Infection by Yellow Fever Virus.

    Abrao, Emiliana Pereira; da Fonseca, Benedito Antônio Lopes

    2016-02-01

    Dengue is one of the most important diseases caused by arboviruses in the world. Yellow fever is another arthropod-borne disease of great importance to public health that is endemic to tropical regions of Africa and the Americas. Both yellow fever and dengue viruses are flaviviruses transmitted by Aedes aegypti mosquitoes, and then, it is reasonable to consider that in a given moment, mosquito cells could be coinfected by both viruses. Therefore, we decided to evaluate if sequential infections of dengue and yellow fever viruses (and vice-versa) in mosquito cells could affect the virus replication patterns. Using immunofluorescence and real-time PCR-based replication assays in Aedes albopictus C6/36 cells with single or sequential infections with both viruses, we demonstrated the occurrence of viral interference, also called superinfection exclusion, between these two viruses. Our results show that this interference pattern is particularly evident when cells were first infected with dengue virus and subsequently with yellow fever virus (YFV). Reduction in dengue virus replication, although to a lower extent, was also observed when C6/36 cells were initially infected with YFV followed by dengue virus infection. Although the importance that these findings have on nature is unknown, this study provides evidence, at the cellular level, of the occurrence of replication interference between dengue and yellow fever viruses and raises the question if superinfection exclusion could be a possible explanation, at least partially, for the reported lack of urban yellow fever occurrence in regions where a high level of dengue transmission occurs.

  14. Fracture of coherent interfaces between an fcc metal matrix and the Cr23C6 carbide precipitate from first principles

    Barbé, Elric; Fu, Chu-Chun; Sauzay, Maxime

    2018-02-01

    It is known that microcrack initiation in metallic alloys containing second-phase particles may be caused by either an interfacial or an intraprecipitate fracture. So far, the dependence of these features on properties of the precipitate and the interface is not clearly known. The present study aims to determine the key properties of carbide-metal interfaces controlling the energy and critical stress of fracture, based on density functional theory (DFT) calculations. We address coherent interfaces between a fcc iron or nickel matrix and a frequently observed carbide, the M23C6 , for which a simplified chemical composition Cr23C6 is assumed. The interfacial properties such as the formation and Griffith energies, and the effective Young's modulus are analyzed as functions of the magnetic state of the metal lattice, including the paramagnetic phase of iron. Interestingly, a simpler antiferromagnetic phase is found to exhibit similar interfacial mechanical behavior to the paramagnetic phase. A linear dependence is determined between the surface (and interface) energy and the variation of the number of chemical bonds weighted by the respective bond strength, which can be used to predict the relative formation energy for the surface and interface with various chemical terminations. Finally, the critical stresses of both intraprecipitate and interfacial fractures due to a tensile loading are estimated via the universal binding energy relation (UBER) model, parametrized on the DFT data. The validity of this model is verified in the case of intraprecipitate fracture, against results from DFT tensile test simulations. In agreement with experimental evidences, we predict a much stronger tendency for an interfacial fracture for this carbide. In addition, the calculated interfacial critical stresses are fully compatible with available experimental data in steels, where the interfacial carbide-matrix fracture is only observed at incoherent interfaces.

  15. ROS enhancement by silicon nanoparticles in X-ray irradiated aqueous suspensions and in glioma C6 cells

    David Gara, Pedro M. [CITOMA, Fundacion Avanzar, Instituto de Terapia Radiante S.A., CIO La Plata (Argentina); Garabano, Natalia I. [University of Buenos Aires, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, UBA (Argentina); Llansola Portoles, Manuel J. [UNLP, INIFTA, Departamento de Quimica, Facultad de Ciencias Exactas (Argentina); Moreno, M. Sergio [Centro Atomico Bariloche (Argentina); Dodat, Diego; Casas, Oscar R. [CITOMA, Fundacion Avanzar, Instituto de Terapia Radiante S.A., CIO La Plata (Argentina); Gonzalez, Monica C., E-mail: gonzalez@inifta.unlp.edu.ar [UNLP, INIFTA, Departamento de Quimica, Facultad de Ciencias Exactas (Argentina); Kotler, Monica L., E-mail: kotler@qb.fcen.uba.ar [University of Buenos Aires, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, UBA (Argentina)

    2012-03-15

    The capability of silicon nanoparticles to increase the yield of reactive species upon 4 MeV X-ray irradiation of aqueous suspensions and C6 glioma cell cultures was investigated. ROS generation was detected and quantified using several specific probes. The particles were characterized by FTIR, XPS, TEM, DLS, luminescence, and adsorption spectroscopy before and after irradiation to evaluate the effect of high energy radiation on their structure. The total concentration of O{sub 2}{sup Bullet -}/HO{sub 2}{sup Bullet}, HO{sup Bullet}, and H{sub 2}O{sub 2} generated upon 4-MeV X-ray irradiation of 6.4 {mu}M silicon nanoparticle aqueous suspensions were on the order of 10 {mu}M per Gy, ten times higher than that obtained in similar experiments but in the absence of particles. Cytotoxic {sup 1}O{sub 2} was generated only in irradiation experiments containing the particles. The particle surface became oxidized to SiO{sub 2} and the luminescence yield reduced with the irradiation dose. Changes in the surface morphology did not affect, within the experimental error, the yields of ROS generated per Gy. X-ray irradiation of glioma C6 cell cultures with incorporated silicon nanoparticles showed a marked production of ROS proportional to the radiation dose received. In the absence of nanoparticles, the cells showed no irradiation-enhanced ROS generation. The obtained results indicate that silicon nanoparticles of <5 nm size have the potential to be used as radiosensitizers for improving the outcomes of cancer radiotherapy. Their capability of producing {sup 1}O{sub 2} upon X-ray irradiation opens novel approaches in the design of therapy strategies.

  16. The extrinsic and intrinsic apoptotic pathways are involved in manganese toxicity in rat astrocytoma C6 cells.

    Alaimo, Agustina; Gorojod, Roxana M; Kotler, Mónica L

    2011-08-01

    Manganese (Mn) is a trace element known to be essential for maintaining the proper function and regulation of many biochemical and cellular reactions. However, chronic exposure to high levels of Mn in occupational or environmental settings can lead to its accumulation in the brain resulting in a degenerative brain disorder referred to as Manganism. Astrocytes are the main Mn store in the central nervous system and several lines of evidence implicate these cells as major players in the role of Manganism development. In the present study, we employed rat astrocytoma C6 cells as a sensitive experimental model for investigating molecular mechanisms involved in Mn neurotoxicity. Our results show that C6 cells undergo reactive oxygen species-mediated apoptotic cell death involving caspase-8 and mitochondrial-mediated pathways in response to Mn. Exposed cells exhibit typical apoptotic features, such as chromatin condensation, cell shrinkage, membrane blebbing, caspase-3 activation and caspase-specific cleavage of the endogenous substrate poly (ADP-ribose) polymerase. Participation of the caspase-8 dependent pathway was assessed by increased levels of FasL, caspase-8 activation and Bid cleavage. The involvement of the mitochondrial pathway was demonstrated by the disruption of the mitochondrial membrane potential, the opening of the mitochondrial permeability transition pore, cytochrome c release, caspase-9 activation and the increased mitochondrial levels of the pro-apoptotic Bcl-2 family proteins. In addition, our data also shows for the first time that mitochondrial fragmentation plays a relevant role in Mn-induced apoptosis. Taking together, these findings contribute to a deeper elucidation of the molecular signaling mechanisms underlying Mn-induced apoptosis. Copyright © 2011 Elsevier B.V. All rights reserved.

  17. Genomic analysis suggests that mRNA destabilization by the microprocessor is specialized for the auto-regulation of Dgcr8.

    Archana Shenoy

    2009-09-01

    Full Text Available The Microprocessor, containing the RNA binding protein Dgcr8 and RNase III enzyme Drosha, is responsible for processing primary microRNAs to precursor microRNAs. The Microprocessor regulates its own levels by cleaving hairpins in the 5'UTR and coding region of the Dgcr8 mRNA, thereby destabilizing the mature transcript.To determine whether the Microprocessor has a broader role in directly regulating other coding mRNA levels, we integrated results from expression profiling and ultra high-throughput deep sequencing of small RNAs. Expression analysis of mRNAs in wild-type, Dgcr8 knockout, and Dicer knockout mouse embryonic stem (ES cells uncovered mRNAs that were specifically upregulated in the Dgcr8 null background. A number of these transcripts had evolutionarily conserved predicted hairpin targets for the Microprocessor. However, analysis of deep sequencing data of 18 to 200nt small RNAs in mouse ES, HeLa, and HepG2 indicates that exonic sequence reads that map in a pattern consistent with Microprocessor activity are unique to Dgcr8.We conclude that the Microprocessor's role in directly destabilizing coding mRNAs is likely specifically targeted to Dgcr8 itself, suggesting a specialized cellular mechanism for gene auto-regulation.

  18. Total dose and dose rate radiation characterization of EPI-CMOS radiation hardened memory and microprocessor devices

    Gingerich, B.L.; Hermsen, J.M.; Lee, J.C.; Schroeder, J.E.

    1984-01-01

    The process, circuit discription, and total dose radiation characteristics are presented for two second generation hardened 4K EPI-CMOS RAMs and a first generation 80C85 microprocessor. Total dose radiation performance is presented to 10M rad-Si and effects of biasing and operating conditions are discussed. The dose rate sensitivity of the 4K RAMs is also presented along with single event upset (SEU) test data

  19. Use of a Microprocessor to Implement an ADCCP Protocol (Federal Std-1003) Operating in the Unbalanced Normal Mode.

    1980-05-01

    andcoptrpormigfrteublne nra ls fpoeue nacrac with Federal Standard 1003 fTelecommunications: Synchronous Bit Oriented Data Link Control Procedures...and the higher level user. The solution to the producer/consumer problem involves the use of PASS and SICHAL primitives and event variables or... semaphores . The event variables have been defined for the LS-microprocessor interface as part of I-1 the internal registers that are included in the F6856

  20. Upset due to a single particle caused propagated transients in a bulk CMOS microprocessor

    Leavy, J.F.; Hoffmann, L.F.; Shoran, R.W.; Johnson, M.T.

    1991-01-01

    This paper reports on data pattern advances observed in preset, single event upset (SEU) hardened clocked flip-flops, during static Cf-252 exposures on a bulk CMOS microprocessor, that were attributable to particle caused anomalous clock signals, or propagated transients. SPICE simulations established that particle strikes in the output nodes of a clock control logic flip-flop could produce transients of sufficient amplitude and duration to be accepted as legitimate pulses by clock buffers fed by the flip-flop's output nodes. The buffers would then output false clock pulses, thereby advancing the state of the present flip-flops. Masking the clock logic on one of the test chips made the flip-flop data advance cease, confirming the clock logic as the source of the SEU. By introducing N 2 gas, at reduced pressures, into the SEU test chamber to attenuate Cf-252 particle LET's, a 24-26 MeV-cm 2 /mg LET threshold was deduced. Subsequent tests, at the 88-inch cyclotron at Berkeley, established an LET threshold of 30 MeV-cm 2 /mg (283 MeV Cu at 0 degrees) for the generation of false clocks. Cyclotron SEU tests are considered definitive, while Cf-252 data usually is not. However, in this instance Cf-252 tests proved analytically useful, providing SEU characterization data that was both timely and inexpensive

  1. Microprocessor-controlled Nd:YAG laser for hyperthermia induction in the RIF-1 tumor.

    Waldow, S M; Russell, G E; Wallner, P E

    1992-01-01

    Near-infrared radiation from a Nd:YAG laser at 1,064 nm was used interstitially or superficially to induce hyperthermia in RIF-1 tumors in C3H male mice. A single 600-microns quartz fiber with a 0.5-cm cylindrical diffusor or a weakly diverging microlens at its distal end was used to deliver laser energy to tumors in the hind leg (mean volume = 100 mm3). Two thermocouples were inserted into each tumor. One thermocouple controlled a microprocessor-driven hyperthermia program (maximum output of 3.5 Watts) to maintain the desired temperature. Tumors were exposed to various temperature-time combinations (42-45 degrees C/30 min). Our initial results indicated that excellent temperature control to within 0.2 degrees C of the desired temperature at the feedback thermocouple was achievable during both superficial and interstitial heat treatments. Temperatures at the second thermocouple, however, were found to be lower by as much as 2.3 degrees C (using the cylindrical diffusor) or higher by up to 4.6 degrees C (using the microlens) when compared to the feedback thermocouple temperature. Several correlations were seen between total dose, tumor growth delay, percent skin necrosis, and temperature at the second thermocouple after several superficial and interstitial treatments. Statistically significant improvements in tumor growth delay (at 42 and 45 degrees C) and increased percent skin necrosis at all temperatures were observed after superficial versus interstitial treatment.

  2. Integrating existing radiation monitors into a microprocessor-based display system

    Kalita, R, S.; Bartucci, C.M.; Mason, R.G.; Greaves, C.

    1992-01-01

    Plantwide digital radiation monitoring systems (RMSs) have been generally installed as part of the original design for newer nuclear reactors. For older plants, area and process radiation monitors were either analog or a combination of analog and digital but were not part of an integrated system design. At some plants, individual monitors have been replaced or modified, resulting in a rainbow of different monitors and vendors being represented at the plant. Usually at some point, consideration is given to replacing these monitors with a state-of-the-art RMS to improve overall reliability and achieve the benefits of sound human factors engineering. This can be a very costly project in terms of expenditures for engineering, equipment, construction, startup, and time. When human engineering deficiencies (HEDs) became an issue at Zion station, Commonwealth Edison elected to install a computer-based radiation monitoring display system (RMDS) that would interface existing raidation monitors. After reviewing the existing as-built RMS configuration and internal circuits of the various monitors, it was concluded that a microprocessor-based RMDS could be successfully designed and installed that would solve the HEDs and would tie the older analog channels into a system configuration. Although in many cases, internal modifications were made to existing RMS monitors, the RMDS upgrade allowed the existing RMS monitors to retain their original functionality and location

  3. Microprocessor control and data acquisition at the LLNL 100-MeV accelerator

    Mendonca, M.L.

    1981-01-01

    A distributed microprocessor control and data acquisition network has been designed for implementation on the Lawrence Livermore National Laboratory 100 MeV electron/positron accelerator (LINAC). The system has been designed to be as transparent to the user as possible by stressing responsiveness, reliability, and relevance of data presented to the user. Implementation of the network will take place in modular fashion in three stages, so as to minimize disruption of normal operations. The first elements to be installed will be the beam transport system controls, beam set-up time. Beam diagnostic equipment is now being position monitors, and accelerator operating status monitors. These units will reduce beam set-up time. Beam diagnostic equipment is now being designed that will be used in a second stage implementation. This stage will concentrate on determining beam parameters and allowing the user to optimize the beam for a given parameter. The final stage will be to install experimenter data acquisition equipment. The equipment will augment the presently existing data acquisition system. The completed network will allow a more efficient operation of the LINAC, resulting in reduced experiment costs, and more controllable beam parameters, both of which are major concerns of experimenters

  4. An 'intelligent' approach to radioimmunoassay sample counting employing a microprocessor-controlled sample counter

    Ekins, R.P.; Sufi, S.; Malan, P.G.

    1978-01-01

    The enormous impact on medical science in the last two decades of microanalytical techniques employing radioisotopic labels has, in turn, generated a large demand for automatic radioisotopic sample counters. Such instruments frequently comprise the most important item of capital equipment required in the use of radioimmunoassay and related techniques and often form a principle bottleneck in the flow of samples through a busy laboratory. It is therefore imperative that such instruments should be used 'intelligently' and in an optimal fashion to avoid both the very large capital expenditure involved in the unnecessary proliferation of instruments and the time delays arising from their sub-optimal use. Most of the current generation of radioactive sample counters nevertheless rely on primitive control mechanisms based on a simplistic statistical theory of radioactive sample counting which preclude their efficient and rational use. The fundamental principle upon which this approach is based is that it is useless to continue counting a radioactive sample for a time longer than that required to yield a significant increase in precision of the measurement. Thus, since substantial experimental errors occur during sample preparation, these errors should be assessed and must be related to the counting errors for that sample. The objective of the paper is to demonstrate that the combination of a realistic statistical assessment of radioactive sample measurement, together with the more sophisticated control mechanisms that modern microprocessor technology make possible, may often enable savings in counter usage of the order of 5- to 10-fold to be made. (author)

  5. Stair ascent with an innovative microprocessor-controlled exoprosthetic knee joint.

    Bellmann, Malte; Schmalz, Thomas; Ludwigs, Eva; Blumentritt, Siegmar

    2012-12-01

    Climbing stairs can pose a major challenge for above-knee amputees as a result of compromised motor performance and limitations to prosthetic design. A new, innovative microprocessor-controlled prosthetic knee joint, the Genium, incorporates a function that allows an above-knee amputee to climb stairs step over step. To execute this function, a number of different sensors and complex switching algorithms were integrated into the prosthetic knee joint. The function is intuitive for the user. A biomechanical study was conducted to assess objective gait measurements and calculate joint kinematics and kinetics as subjects ascended stairs. Results demonstrated that climbing stairs step over step is more biomechanically efficient for an amputee using the Genium prosthetic knee than the previously possible conventional method where the extended prosthesis is trailed as the amputee executes one or two steps at a time. There is a natural amount of stress on the residual musculoskeletal system, and it has been shown that the healthy contralateral side supports the movements of the amputated side. The mechanical power that the healthy contralateral knee joint needs to generate during the extension phase is also reduced. Similarly, there is near normal loading of the hip joint on the amputated side.

  6. SEU simulation and testing of resistor-hardened D-latches in the SA3300 microprocessor

    Sexton, F.W.; Corbett, W.T.; Treece, R.K.; Hass, K.J.; Axness, C.L.; Hash, G.L.; Shaneyfelt, M.R.; Wunsch, T.F.; Hughes, K.L.

    1991-01-01

    In this paper the SEU tolerance of the SA3300 microprocessor with feedback resistors is presented and compared to the SA3300 without feedback resistors and to the commercial version (NS32016). Upset threshold at room temperature increased from 23 MeV-cm 2 /mg and 180 MeV-cm 2 /mg with feedback resistors of 50 kΩ and 160 kΩ, respectively. The performance goal of 10 MHz over the full temperature range of -55 degrees C to +125 degrees C is exceeded for feedback resistors of 160 kΩ and less. Error rate calculations for this design predict that the error rate is less than once every 100 years when 50 kΩ feedback resistors are used in the D-latch design. Analysis of the SEU response using a lumped-parameter circuit simulator imply a charge collection depth of 4.5 μm. This is much deeper than the authors would expect for prompt collection in the epi and funnel regions and has been explained in terms of diffusion current in the heavily doped substrate

  7. 'Intelligent' approach to radioimmunoassay sample counting employing a microprocessor controlled sample counter

    Ekins, R.P.; Sufi, S.; Malan, P.G.

    1977-01-01

    The enormous impact on medical science in the last two decades of microanalytical techniques employing radioisotopic labels has, in turn, generated a large demand for automatic radioisotopic sample counters. Such instruments frequently comprise the most important item of capital equipment required in the use of radioimmunoassay and related techniques and often form a principle bottleneck in the flow of samples through a busy laboratory. It is therefore particularly imperitive that such instruments should be used 'intelligently' and in an optimal fashion to avoid both the very large capital expenditure involved in the unnecessary proliferation of instruments and the time delays arising from their sub-optimal use. The majority of the current generation of radioactive sample counters nevertheless rely on primitive control mechanisms based on a simplistic statistical theory of radioactive sample counting which preclude their efficient and rational use. The fundamental principle upon which this approach is based is that it is useless to continue counting a radioactive sample for a time longer than that required to yield a significant increase in precision of the measurement. Thus, since substantial experimental errors occur during sample preparation, these errors should be assessed and must be releted to the counting errors for that sample. It is the objective of this presentation to demonstrate that the combination of a realistic statistical assessment of radioactive sample measurement, together with the more sophisticated control mechanisms that modern microprocessor technology make possible, may often enable savings in counter usage of the order of 5-10 fold to be made. (orig.) [de

  8. Entericidin is required for a probiotic treatment (Enterobacter sp. strain C6-6) to protect trout from cold-water disease challenge.

    Schubiger, Carla B; Orfe, Lisa H; Sudheesh, Ponnerassery S; Cain, Kenneth D; Shah, Devendra H; Call, Douglas R

    2015-01-01

    Flavobacterium psychrophilum causes bacterial cold-water disease in multiple fish species, including salmonids. An autochthonous Enterobacter strain (C6-6) inhibits the in vitro growth of F. psychrophilum, and when ingested as a putative probiotic, it provides protection against injection challenge with F. psychrophilum in rainbow trout. In this study, low-molecular-mass (≤3 kDa) fractions from both Enterobacter C6-6 and Escherichia coli K-12 culture supernatants inhibited the growth of F. psychrophilum. The ≤3-kDa fraction from Enterobacter C6-6 was analyzed by SDS-PAGE, and subsequent tandem mass spectroscopy identified EcnB, which is a small membrane lipoprotein that is a putative pore-forming toxin. Agar plate diffusion assays demonstrated that ecnAB knockout strains of both Enterobacter C6-6 and E. coli K-12 no longer inhibited F. psychrophilum (P ) and the wild-type strain (C6-6) were added to the fish diet every day for 38 days. On day 11, the fish were challenged by injection with a virulent strain of F. psychrophilum (CSF 259-93). Fish that were fed C6-6 had significantly longer survival than fish fed the ecnAB knockout strain (P Enterobacter C6-6, and it may present new opportunities for therapeutic and prophylactic treatments against similarly susceptible pathogens. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  9. C6 Coefficients and Dipole Polarizabilities for All Atoms and Many Ions in Rows 1-6 of the Periodic Table.

    Gould, Tim; Bučko, Tomáš

    2016-08-09

    Using time-dependent density functional theory (TDDFT) with exchange kernels, we calculate and test imaginary frequency-dependent dipole polarizabilities for all atoms and many ions in rows 1-6 of the periodic table. These are then integrated over frequency to produce C6 coefficients. Results are presented under different models: straight TDDFT calculations using two different kernels; "benchmark" TDDFT calculations corrected by more accurate quantum chemical and experimental data; and "benchmark" TDDFT with frozen orbital anions. Parametrizations are presented for 411+ atoms and ions, allowing results to be easily used by other researchers. A curious relationship, C6,XY ∝ [αX(0)αY(0)](0.73), is found between C6 coefficients and static polarizabilities α(0). The relationship C6,XY = 2C6,XC6,Y/[(αX/αY)C6,Y + (αY/αX)C6,X] is tested and found to work well (30% errors) in a small fraction of cases.

  10. Optimization of hydrothermal pretreatment for co-utilization C-5 and C-6 sugars of cassava alcohol residue

    Lu, Huisheng; Lv, Chunliu; Zhang, Minhua; Liu, Shuangyan; Liu, Jiatao; Lian, Feng

    2017-01-01

    Highlights: • Cassava alcohol residue was first pretreated by hydrothermal reaction. • Hydrothermal pretreatment was optimized by RSM for co-utilization of C-5 and C-6 sugars. • The maximum xylose yield and the highest enzymatic digestibility were not obtained at the same conditions. • Optimum pretreatment conditions were at 193 °C, with 11.4% solids and for 51 min. • The optimal theoretical ethanol production was 69.5 mg/g raw materials by co-utilization of C-5 and C-6 sugars. - Abstract: Hydrothermal reaction was first applied to pretreat cassava alcohol residue for realizing the co-utilization of xylose and glucose to assume fermentation ethanol. This work focused on the influence of hydrothermal pretreatment conditions on ethanol production. Hydrothermal reaction was used to explore the maximum xylose and glucose yields, in respect to reaction temperature (120–240 °C), solid-liquid ratio (0.023–0.150) and reaction time (15–120 min). The results showed that the suitable conditions were at 180–200 °C, for 45–60 min and with 10–12.5% solids. In this range, the conjunct of xylose and glucose would reach the maximum, which can make full use of hemicellulose and cellulose in cassava alcohol residue. According to the results, respond surface methodology (RSM) based on Box-Behnken design was used to further optimize the three independent variables for the highest ethanol by co-utilization of xylose and glucose. RSM revealed that the effect of temperature on ethanol production was much more significant than the effect of reaction time and solid-liquid ratio, and the highest ethanol production was 70.6 mg/g that was close to the experiment value of 69.5 mg/g at 193 °C for 51 min and with 11.5% solids. Furthermore, the crystallinity and morphology of the untreated and pretreated cassava alcohol residue were investigated to assess the effect of hydrothermal pretreatment by scanning electron microscope (SEM) and X-ray diffraction (XRD

  11. Quantitative Proteomic Analysis of Mosquito C6/36 Cells Reveals Host Proteins Involved in Zika Virus Infection.

    Xin, Qi-Lin; Deng, Cheng-Lin; Chen, Xi; Wang, Jun; Wang, Shao-Bo; Wang, Wei; Deng, Fei; Zhang, Bo; Xiao, Gengfu; Zhang, Lei-Ke

    2017-06-15

    Zika virus (ZIKV) is an emerging arbovirus belonging to the genus Flavivirus of the family Flaviviridae During replication processes, flavivirus manipulates host cell systems to facilitate its replication, while the host cells activate antiviral responses. Identification of host proteins involved in the flavivirus replication process may lead to the discovery of antiviral targets. The mosquitoes Aedes aegypti and Aedes albopictus are epidemiologically important vectors for ZIKV, and effective restrictions of ZIKV replication in mosquitoes will be vital in controlling the spread of virus. In this study, an iTRAQ-based quantitative proteomic analysis of ZIKV-infected Aedes albopictus C6/36 cells was performed to investigate host proteins involved in the ZIKV infection process. A total of 3,544 host proteins were quantified, with 200 being differentially regulated, among which CHCHD2 can be upregulated by ZIKV infection in both mosquito C6/36 and human HeLa cells. Our further study indicated that CHCHD2 can promote ZIKV replication and inhibit beta interferon (IFN-β) production in HeLa cells, suggesting that ZIKV infection may upregulate CHCHD2 to inhibit IFN-I production and thus promote virus replication. Bioinformatics analysis of regulated host proteins highlighted several ZIKV infection-regulated biological processes. Further study indicated that the ubiquitin proteasome system (UPS) plays roles in the ZIKV entry process and that an FDA-approved inhibitor of the 20S proteasome, bortezomib, can inhibit ZIKV infection in vivo Our study illustrated how host cells respond to ZIKV infection and also provided a candidate drug for the control of ZIKV infection in mosquitoes and treatment of ZIKV infection in patients. IMPORTANCE ZIKV infection poses great threats to human health, and there is no FDA-approved drug available for the treatment of ZIKV infection. During replication, ZIKV manipulates host cell systems to facilitate its replication, while host cells activate

  12. Et2NH2C6H3(CO23SnBr2.4H2O: SYNTHESIS AND INFRARED STUDY

    DAOUDA NDOYE

    2014-01-01

    Full Text Available The title compound has been obtained on allowing [C6H3(CO23(Et2NH23] to react with SnBr4. The molecular structure of Et2NH2C6H3(CO23SnBr2.4H2O has been determined on the basis of the infrared data. The suggested structure is a dimer in which each tin atom is hexacoordinated by two chelating C6H3(CO233- anions and two Br atoms. Cy2NH2+cations are involved through hydrogen bonds with non-coordinating CO2 groups. The suggested structure is a cage.

  13. Bis(arene) actinide sandwich complexes, (η6-C6H3R3)2An: Linear or bent?

    Li, J.; Bursten, B.E.

    1999-01-01

    The syntheses of the sandwich complexes ferrocene, (η 5 -C 5 H 5 ) 2 -Fe, in 1951 and uranocene, (η 8 -C 8 H 8 ) 2 U, in 1968 ushered in the modern eras of organotransition metal and organoactinide chemistry, respectively. Ferrocene and uranocene are examples of linear sandwich complexes, that is, those in which the (ring centroid)-M-(ring centroid) angle (denoted θ) is 180 degree. In the case of (η 5 -C 5 H 5 ) 2 M chemistry, a number of bent (θ 2 An (An = Th-Am) and (η 6 -C 6 H 3 R 3 ) 2 An (An = Th, U, Pu; R = Me, t Bu) obtained by using local density approximation (LDA) and Perdew-Wang (PW91) gradient-corrected relativistic density functional theory (DFT) methods. These DFT methods are found to be able to reproduce the experimental geometries and vibrational frequencies of organoactinide complexes with satisfactory accuracy. The (TTB) 2 An calculations that are reported here are, to date, the largest full geometry optimizations to be carried out on an actinide system

  14. Mechanism of isotactic styrene polymerization with a C 6F 5-substituted bis(phenoxyimine) titanium system

    Caporaso, Lucia; Loria, Marianna; Mazzeo, Mina; Michiue, Kenji; Nakano, Takashi; Fujita, Terunori; Cavallo, Luigi

    2012-01-01

    We report a combined, experimental and theoretical, study of styrene polymerization to clarify the regio- and stereocontrol mechanism operating with a C 6F 5-substituted bis(phenoxyimine) titanium dichloride complex. Styrene homopolymerization, styrene-propene and styrene-ethene-propene copolymerizations have been carried out to this aim. A combination of 13C NMR analysis of the chain-end groups and of the microstructure of the homopolymers and copolymers reveals that styrene polymerization is highly regioselective and occurs prevalently through 2,1-monomer insertion. DFT calculations evidenced that steric interaction between the growing chain and the monomer in the transition state insertion stage is at the origin of this selectivity. The formation of isotactic polystyrene with a chain-end like microstructure is rationalized on the base of a mechanism similar to that proposed for the syndiospecific propene polymerization catalyzed by bis(phenoxyimine) titanium dichloride complexes. Finally, a general stereocontrol mechanism operative in olefin polymerization with this class of complexes is proposed. © 2012 American Chemical Society.

  15. Physiological and transcriptional approaches reveal connection between nitrogen and manganese cycles in Shewanella algae C6G3

    Aigle, Axel; Bonin, Patricia; Iobbi-Nivol, Chantal; Méjean, Vincent; Michotey, Valérie

    2017-03-01

    To explain anaerobic nitrite/nitrate production at the expense of ammonium mediated by manganese oxide (Mn(IV)) in sediment, nitrate and manganese respirations were investigated in a strain (Shewanella algae C6G3) presenting these features. In contrast to S. oneidensis MR-1, a biotic transitory nitrite accumulation at the expense of ammonium was observed in S. algae during anaerobic growth with Mn(IV) under condition of limiting electron acceptor, concomitantly, with a higher electron donor stoichiometry than expected. This low and reproducible transitory accumulation is the result of production and consumption since the strain is able to dissimilative reduce nitrate into ammonium. Nitrite production in Mn(IV) condition is strengthened by comparative expression of the nitrate/nitrite reductase genes (napA, nrfA, nrfA-2), and rates of the nitrate/nitrite reductase activities under Mn(IV), nitrate or fumarate conditions. Compared with S. oneidensis MR-1, S. algae contains additional genes that encode nitrate and nitrite reductases (napA-α and nrfA-2) and an Outer Membrane Cytochrome (OMC)(mtrH). Different patterns of expression of the OMC genes (omcA, mtrF, mtrH and mtrC) were observed depending on the electron acceptor and growth phase. Only gene mtrF-2 (SO1659 homolog) was specifically expressed under the Mn(IV) condition. Nitrate and Mn(IV) respirations seem connected at the physiological and transcriptional levels.

  16. Comblike poly(ethylene oxide)/hydrophobic C6 branched chitosan surfactant polymers as anti-infection surface modifying agents.

    Mai-ngam, Katanchalee

    2006-05-01

    A series of structurally well-defined poly(ethylene oxide)/hydrophobic C6 branched chitosan surfactant polymers that undergo surface induced self assembly on hydrophobic biomaterial surfaces were synthesized and characterized. The surfactant polymers consist of low molecular weight (Mw) chitosan backbone with hydrophilic poly(ethylene oxide) (PEO) and hydrophobic hexyl pendant groups. Chitosan was depolymerized by nitrous acid deaminative cleavage. Hexanal and aldehyde-terminated PEO chains were simultaneously attached to low Mw chitosan hydrochloride via reductive amination. The surfactant polymers were prepared with various ratios of the two side chains. The molecular composition of the surfactant polymers was determined by FT-IR and 1H NMR. Surface active properties at the air-water interface were determined by Langmuir film balance measurements. The surfactant polymers with PEO/hexyl ratios of 1:3.0 and 1:14.4 were used as surface modifying agents to investigate their anti-infection properties. E. coli adhesion on Silastic surface was decreased significantly by the surfactant polymer with PEO/hexyl 1:3.0. Surface growth of adherent E. coli was effectively suppressed by both tested surfactant polymers.

  17. N-(4-Hydroxyphenyl) retinamide potentiated paclitaxel for cell cycle arrest and apoptosis in glioblastoma C6 and RG2 cells

    Janardhanan, Rajiv; Butler, Jonathan T.; Banik, Naren L.; Ray, Swapan K.

    2009-01-01

    Glioblastoma grows aggressively due to its ability to maintain abnormally high potentials for cell proliferation. The present study examines the synergistic actions of N-(4-hdroxyphenyl) retinamide (4-HPR) and paclitaxel (PTX) to control the growth of rat glioblastoma C6 and RG2 cell lines. 4-HPR induced astrocytic differentiation was accompanied by increased expression of the tight junction protein e-cadherin and sustained down regulation of Id2 (member of inhibitor of differentiation family), catalytic subunit of rat telomerase reverse transcriptase (rTERT), and proliferating cell nuclear antigen (PCNA). Flow cytometric analysis showed that the microtubule stabilizer PTX caused cell cycle deregulation due to G2/M arrest. This in turn could alter the fate of kinetochore-spindletube dynamics thereby halting cell cycle progression. An interesting observation was induction of G1/S arrest by combination of 4-HPR and PTX, altering the G2/M arrest induced by PTX alone. This was further ratified by the upregulation of tumor suppressor protein retinoblastoma, which repressed the expression of the key signaling moieties to induce G1/S arrest. Collectively, combination of 4-HPR and PTX diminished the survival factors (e.g., rTERT, PCNA, and Bcl-2) to make glioblastoma cells highly prone to apoptosis with activation of cysteine proteases (e.g., calpain, cathepsins, caspase-8, caspase-3) in two glioblastoma cell lines. Hence, combination 4-HPR and PTX can be considered as an effective therapeutic strategy for controlling the growth of heterogeneous glioblastoma cell populations. PMID:19285047

  18. Sustainable Synthesis of Oxalic and Succinic Acid through Aerobic Oxidation of C6 Polyols Under Mild Conditions.

    Ventura, Maria; Williamson, David; Lobefaro, Francesco; Jones, Matthew D; Mattia, Davide; Nocito, Francesco; Aresta, Michele; Dibenedetto, Angela

    2018-03-22

    The sustainable chemical industry encompasses a shift from the use of fossil carbon to renewable carbon. The synthesis of chemicals from nonedible biomass (cellulosic or oil) represents one of the key steps for "greening" the chemical industry. In this paper, we report the aerobic oxidative cleavage of C6 polyols (5-HMF, glucose, fructose and sucrose) to oxalic acid (OA) and succinic acid (SA) in water under mild conditions using M@CNT and M@NCNT (M=Fe, V; CNT=carbon nanotubes; NCNT=N-doped CNT), which, under suitable conditions, were recoverable and reusable without any loss of efficiency. The influence of the temperature, O 2 pressure (PO2 ), reaction time and stirring rate are discussed and the best reaction conditions are determined for an almost complete conversion of the starting material and a good OA yield of 48 %. SA and formic acid were the only co-products. The former could be further converted into OA by oxidation in the presence of formic acid, resulting in an overall OA yield of >62 %. This process was clean and did not produce organic waste nor gas emissions. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. 16O resonances near the 4α threshold through the 12C(6Li,d) reaction

    Rodrigues, M. R. D.; Borello-Lewin, T.; Miyake, H.; Duarte, J. L. M.; Rodrigues, C. L.; Souza, M. A.; Horodynski-Matsushigue, L. B.; Ukita, G. M.; Cappuzzello, F.; Cunsolo, A.; Cavallaro, M.; Agodi, C.; Foti, A.

    2014-02-01

    Background: Resonances around xα thresholds in light nuclei are recognized to be important in basic aspects of nuclear structure. However, there is scarce experimental information associated with them. Purpose: We study the α-clustering phenomenon in resonant states around the 4α threshold (14.44 MeV) in the 16O nucleus. Method: The 12C(6Li,d )16O reaction was investigated with an unprecedented resolution at a bombarding energy of 25.5 MeV by employing the São Paulo Pelletron-Enge-Spectrograph facility and the nuclear emulsion technique. Results: Several narrow resonances were populated and the energy resolution of 15 keV allows for the separation of doublet states that were not resolved previously. The upper limits for the resonance widths in this region were extracted. The angular distributions of the absolute differential cross section associated with four natural parity quasibound states are presented and compared to distorted wave Born approximation predictions. Conclusions: Narrow resonances not previously reported in the literature were observed. This indicates that the α-cluster structure information in this region should be revised.

  20. Mechanism of isotactic styrene polymerization with a C 6F 5-substituted bis(phenoxyimine) titanium system

    Caporaso, Lucia

    2012-11-13

    We report a combined, experimental and theoretical, study of styrene polymerization to clarify the regio- and stereocontrol mechanism operating with a C 6F 5-substituted bis(phenoxyimine) titanium dichloride complex. Styrene homopolymerization, styrene-propene and styrene-ethene-propene copolymerizations have been carried out to this aim. A combination of 13C NMR analysis of the chain-end groups and of the microstructure of the homopolymers and copolymers reveals that styrene polymerization is highly regioselective and occurs prevalently through 2,1-monomer insertion. DFT calculations evidenced that steric interaction between the growing chain and the monomer in the transition state insertion stage is at the origin of this selectivity. The formation of isotactic polystyrene with a chain-end like microstructure is rationalized on the base of a mechanism similar to that proposed for the syndiospecific propene polymerization catalyzed by bis(phenoxyimine) titanium dichloride complexes. Finally, a general stereocontrol mechanism operative in olefin polymerization with this class of complexes is proposed. © 2012 American Chemical Society.

  1. Studies of 12C6+ heavy ions irradiation on seed germination and young seedling growth of four crops

    Sun Landi; Zhang Yingcong; Wu Dali; Liang Kai; Zhang Yanping; Jia Ruiling; Qin Qianqian; Cheng Xi; Qian Pingping; Li Wenjian; Hou Suiwen

    2008-01-01

    Crops of Brassica napus L., Linum usitatissmum L., Allium f istulosum L. and Lens culinaris Medic. were irradiated by 80 MeV/u 12 C 6+ ion beams with doses of 30, 90 and 180 Gy. The germination rates and heights of seedlings of M 1 and M 2 generation of these four plants were studied. The results indicated that germination rates and average heights of the B. napus and L. usitatissmum were improved by appropriate dose treatment, while great suppression was found in the irradiated groups of the A. fistulosum. As far as the L. Culinaris was concerned, little differences was observed on M 1 germination rate, but the 90 Gy irradiation was favorable to growth of plant. The treatments with 30, 90 and 180 Gy were inferior to contrast one on M 2 germination rate of the four species. Seedlings of M 2 generation of the B. napus, L. sitatissmum and L. culinaris under 30 Gy grew better than the other groups, while the best performance of the A. fistulosum was shown by the control group. (authors)

  2. Identification of a 48 kDa tubulin or tubulin-like C6/36 mosquito cells protein that binds dengue virus 2 using mass spectrometry

    Chee, H.-Y.; AbuBakar, Sazaly

    2004-01-01

    Binding of dengue virus 2 (DENV-2) to C6/36 mosquito cells protein was investigated. A 48 kDa DENV-2-binding C6/36 cells protein (D2BP) was detected in a virus overlay protein-binding assay. The binding occurred only to the C6/36 cells cytosolic protein fraction and it was inhibited by free D2BP. D2BP was shown to bind to DENV-2 E in the far-Western-binding studies and using mass spectrometry (MS) and MS/MS, peptide masses of the D2BP that matched to β-tubulin and α-tubulin chains were identified. These findings suggest that DENV-2 through DENV-2 E binds directly to a 48 kDa tubulin or tubulin-like protein of C6/36 mosquito cells

  3. Aspects of transmetallation reactions of 2-Me2NCH2C6H4- and 2,6-(Me2NCH2)-C6H3-metal (Pd,Pt,Hg,Tl) complexes with metal carboxylates and low-valent metal (Pd,Pt) complexes

    Koten, G. van; Ploeg, A.F.M.J. van der; Vrieze, K.

    1981-01-01

    A study has been made of reactions involving organometallic compounds containing ortho-Me{2}NCH{2} substituted aryl ligands. The single step syntheses of the new compounds [(2-Me{2}NCH{2}C{6}H{4}){2}TlCl], [ [{(S)-2-Me{2}NCH(Me)C{6}H{4}}{2}TlCl], [{(S)-2-Me{2}NCH(Me)C{6}H{4}}TlCl{2}], [{2,

  4. Reactivity of Amine/E(C6F53 (E = B, Al Lewis Pairs toward Linear and Cyclic Acrylic Monomers: Hydrogenation vs. Polymerization

    Jiawei Chen

    2015-05-01

    Full Text Available This work reveals the contrasting reactivity of amine/E(C6F53 (E = B, Al Lewis pairs toward linear and cyclic acrylic monomers, methyl methacrylate (MMA and biorenewable γ-methyl-α-methylene-γ-butyrolactone (γMMBL. While mixing of 2,2,6,6-tetramethylpiperidine (TMP and B(C6F53 leads to a frustrated Lewis pair (FLP, Et3N reacts with B(C6F53 to form disproportionation products, ammonium hydridoborate ionic pair and iminium zwitterion. On the other hand, the stoichiometric reaction of either TMP or Et3N with Al(C6F53 leads to clean formation of a classic Lewis adduct (CLA. Neither TMP nor Et3N, when paired with E(C6F53, polymerizes MMA, but the Et3N/2B(C6F53 pair promotes transfer hydrogenation of MMA to form methyl isobutyrate. In contrast, the amine/E(C6F53 pairs promote rapid polymerization of γMMBL carrying the more reactive exocyclic methylene moiety, achieving full conversion in less than 3 min even at a low catalyst loading of 0.0625 mol %. TMP is more effective than Et3N for the polymerization when paired with either the borane or the alane, while the alane exhibits higher polymerization activity than the borane when paired with Et3N. Overall, the TMP/Al(C6F53 system exhibits the highest polymerization activity, achieving a maximum turn-over frequency of 96,000 h−1 at 0.125 mol % of catalyst loading, producing high molecular weight PγMMBL with Mn = 1.29 × 105 g∙mol−1.

  5. Genetic, biochemical, and structural characterization of a new densovirus isolated from a chronically infected Aedes albopictus C6/36 cell line

    Chen Senxiong; Cheng Lingpeng; Zhang Qinfen; Lin Wei; Lu Xinying; Brannan, Jennifer; Zhou, Z.H.; Zhang Jingqiang

    2004-01-01

    We report the isolation, sequencing, biochemical, and structural characterization of a previously undescribed virus in a chronically infected Aedes albopictus C6/36 cell line. This virus is identified as a new densovirus under the Densovirinae subfamily of the Parvoviridae based on its biological and morphologic properties as well as sequence homologies, and is tentatively designated A. albopictus C6/36 cell densovirus (C6/36 DNV). Analysis of the 4094 nt of the C6/36 DNV genome revealed that the plus strand had three large open reading frames (ORFs): a left ORF, a right ORF, and a mid-ORF (within the left ORF), whose potential coding capacities are 91.0, 40.8, and 41.2 kDa, respectively. The left ORF likely encodes the nonstructural protein NS-1, which contains NTP-binding and helicase domains. The right ORF likely encodes structural proteins, VP1 and VP2. Our analyses revealed that C6/36 DNV has a similar genomic organization and shares very high homology in nucleotide sequence and amino acid sequences with Aedes aegypti densovirus (AaeDNV) and A. albopictus densovirus (AalDNV), members of the genus Brevidensovirus of the Densovirinae. Similar to other densoviruses, C6/36 DNV has a different genomic organization and no recognizable sequence homology with viruses in the Parvovirinae. The three-dimensional (3D) reconstruction of the C6/36 DNV at 15.6-A resolution by electron cryomicroscopy (cryoEM) revealed distinctive outer surface features not previously seen in other parvoviruses, indicating structural divergence of densoviruses, in addition to its genomic differences, while the inner surface of the C6/36 DNV capsid exhibits features that are conserved among parvoviruses

  6. Dual photon absorptiometer utilizing a HpGe detector and microprocessor controller

    Ellis, K.J.; Vartsky, D.; Pearlstein, T.B.; Alberi, J.L.; Cohn, S.H.

    1978-01-01

    The analysis of bone mineral content (BMC) using a single energy-photon beam assumes that there are only two materials present, bone mineral and a uniform soft tissue component. Uncertainty in the value of BMC increases with different adipose tissue components in the transmitted beam. These errors, however, are reduced by the dual energy technique. Also, extension to additional energies further identifies the separate constituents of the soft tissue component. A multi-energy bone scanning apparatus with data acquisition and analysis capability sufficient to perform multi-energy analysis of bone mineral content was designed and developed. The present work reports on the development of device operated in the dual energy mode. The high purity germanium (HpGe) detector is an integral component of the scanner. Errors in BMC due to multiple small angle scatters are reduced due to the excellent energy resolution of the detector (530 eV at 60 keV). Also, the need to filter the source or additional collimation on the detector is eliminated. A new dual source holder was designed using 200 mCi 125 I and 100 mCi 241 Am. The active areas of the two source capsules are aligned on a common axis. The congruence of the dual source was verified by measuring the collimator response function. This new holder design insures that the same tissue mass simultaneously attenuates both sources. The controller portion of the microprocessor allows for variation in total scan length, step size, and counting time per step. These options allow for multiple measurements without changes in the detector, source, or collimator. The system has been successfully used to determine the BMC content of different bones

  7. Investigating effect of fusion gene therapy by MR diffusion-weighted imaging in a rat C6 glioma model

    Shen Huicong; Dai Jianping; Wei Xinhua; Wang Jianjiao; Li Shaowu; Ma Jun; Ai Lin; Liu Fengsheng; Chai Qi; Zhao Weijiang; Gao Peiyi

    2008-01-01

    Objective: To evaluate the use of diffusion-weighted imaging (DWI) for early detection of tumor response to Angiostatin-Endostatin (Statin-AE) fusion gene therapy in a rat C6 glioma model. Methods: Fifty male wistar rats with C6 tumor cells implanted into the striatum were examined by a 3.0T MR scanner, then the rats bearing tumors were divided into two groups, treatment group and control group. Rats in the treatment group received 107 plaque forming unit (pfu) recombinant herps simplex viral (R-HSV) mediated Statin-AE fusion gene therapy on day 7, and then the tumors were conformed on MRI. Conventional MR and DWI examination were acquired on 1, 2, 3 weeks after implantation with a 5-inch surface coil. Two (1 w), eight (2 w) and all the residual rats (3 w) of each group were sacrificed to perform the histopathological examination after each MRI examination. Pretreatment and post treatment tumor volumes and apparent diffusion coefficient (ADC) values were calculated. Bank sum test and t test were employed for statistical analysis. Results: On MRI, 43 rats demonstrated tumors on day 7 with a successful rate of 86%. On week 2, the tumor volumes of the controls and treatment group were 90. 6 and 91.64 mm 3 , with no significant difference (Z=-0.14, P>0.05). On week 3, the tumor volumes of the controls and treatment group were 156.64 and 29.64 mm 3 , and a significant difference was observed (Z=-3.45, P -3 and (0.99 ± 0.08) x 10 -3 mm 2 /s, and the values of the tumor peripheral parts of the two groups were (1.00 ± 0.25) x 10 -3 and (0.83 ± 0.12) x 10 -3 mm 2 /s, the ADC values of both tumor centers and peripheral parts of the treatment group were significantly higher than those of the control group (t=-0.82 and -0.46, P -3 and (0.99 ± 0.09) x 10 -3 mm 2 /s, and the values of the tumor peripheral parts of the two groups were (0.81±0.19) x 10 -3 and (0.78±0.11) x 10 -3 mm 2 /s, there were no statistical difference between the two groups (t=0.82, and -0.46, P<0

  8. Remarkable Enhancement of the Hole Mobility in Several Organic Small-Molecules, Polymers, and Small-Molecule:Polymer Blend Transistors by Simple Admixing of the Lewis Acid p-Dopant B(C6F5)3.

    Panidi, Julianna; Paterson, Alexandra F; Khim, Dongyoon; Fei, Zhuping; Han, Yang; Tsetseris, Leonidas; Vourlias, George; Patsalas, Panos A; Heeney, Martin; Anthopoulos, Thomas D

    2018-01-01

    Improving the charge carrier mobility of solution-processable organic semiconductors is critical for the development of advanced organic thin-film transistors and their application in the emerging sector of printed electronics. Here, a simple method is reported for enhancing the hole mobility in a wide range of organic semiconductors, including small-molecules, polymers, and small-molecule:polymer blends, with the latter systems exhibiting the highest mobility. The method is simple and relies on admixing of the molecular Lewis acid B(C 6 F 5 ) 3 in the semiconductor formulation prior to solution deposition. Two prototypical semiconductors where B(C 6 F 5 ) 3 is shown to have a remarkable impact are the blends of 2,8-difluoro-5,11-bis(triethylsilylethynyl)anthradithiophene:poly(triarylamine) (diF-TESADT:PTAA) and 2,7-dioctyl[1]-benzothieno[3,2-b][1]benzothiophene:poly(indacenodithiophene-co-benzothiadiazole) (C8-BTBT:C16-IDTBT), for which hole mobilities of 8 and 11 cm 2 V -1 s -1 , respectively, are obtained. Doping of the 6,13-bis(triisopropylsilylethynyl)pentacene:PTAA blend with B(C 6 F 5 ) 3 is also shown to increase the maximum hole mobility to 3.7 cm 2 V -1 s -1 . Analysis of the single and multicomponent materials reveals that B(C 6 F 5 ) 3 plays a dual role, first acting as an efficient p-dopant, and secondly as a microstructure modifier. Semiconductors that undergo simultaneous p-doping and dopant-induced long-range crystallization are found to consistently outperform transistors based on the pristine materials. Our work underscores Lewis acid doping as a generic strategy towards high performance printed organic microelectronics.

  9. Remarkable Enhancement of the Hole Mobility in Several Organic Small‐Molecules, Polymers, and Small‐Molecule:Polymer Blend Transistors by Simple Admixing of the Lewis Acid p‐Dopant B(C6F5)3

    Panidi, Julianna; Paterson, Alexandra F.; Khim, Dongyoon; Fei, Zhuping; Han, Yang; Tsetseris, Leonidas; Vourlias, George; Patsalas, Panos A.; Heeney, Martin

    2017-01-01

    Abstract Improving the charge carrier mobility of solution‐processable organic semiconductors is critical for the development of advanced organic thin‐film transistors and their application in the emerging sector of printed electronics. Here, a simple method is reported for enhancing the hole mobility in a wide range of organic semiconductors, including small‐molecules, polymers, and small‐molecule:polymer blends, with the latter systems exhibiting the highest mobility. The method is simple and relies on admixing of the molecular Lewis acid B(C6F5)3 in the semiconductor formulation prior to solution deposition. Two prototypical semiconductors where B(C6F5)3 is shown to have a remarkable impact are the blends of 2,8‐difluoro‐5,11‐bis(triethylsilylethynyl)anthradithiophene:poly(triarylamine) (diF‐TESADT:PTAA) and 2,7‐dioctyl[1]‐benzothieno[3,2‐b][1]benzothiophene:poly(indacenodithiophene‐co‐benzothiadiazole) (C8‐BTBT:C16‐IDTBT), for which hole mobilities of 8 and 11 cm2 V−1 s−1, respectively, are obtained. Doping of the 6,13‐bis(triisopropylsilylethynyl)pentacene:PTAA blend with B(C6F5)3 is also shown to increase the maximum hole mobility to 3.7 cm2 V−1 s−1. Analysis of the single and multicomponent materials reveals that B(C6F5)3 plays a dual role, first acting as an efficient p‐dopant, and secondly as a microstructure modifier. Semiconductors that undergo simultaneous p‐doping and dopant‐induced long‐range crystallization are found to consistently outperform transistors based on the pristine materials. Our work underscores Lewis acid doping as a generic strategy towards high performance printed organic microelectronics. PMID:29375962

  10. Remarkable Enhancement of the Hole Mobility in Several Organic Small-Molecules, Polymers, and Small-Molecule:Polymer Blend Transistors by Simple Admixing of the Lewis Acid p-Dopant B(C6F5)3

    Panidi, Julianna; Paterson, Alexandra F.; Khim, Dongyoon; Fei, Zhuping; Han, Yang; Tsetseris, Leonidas; Vourlias, George; Patsalas, Panos A.; Heeney, Martin; Anthopoulos, Thomas D.

    2017-01-01

    Improving the charge carrier mobility of solution-processable organic semiconductors is critical for the development of advanced organic thin-film transistors and their application in the emerging sector of printed electronics. Here, a simple method is reported for enhancing the hole mobility in a wide range of organic semiconductors, including small-molecules, polymers, and small-molecule:polymer blends, with the latter systems exhibiting the highest mobility. The method is simple and relies on admixing of the molecular Lewis acid B(C6F5)(3) in the semiconductor formulation prior to solution deposition. Two prototypical semiconductors where B(C6F5)(3) is shown to have a remarkable impact are the blends of 2,8-difluoro-5,11-bis(triethylsilylethynyl)anthradithiophene:poly(triarylamine) (diF-TESADT:PTAA) and 2,7-dioctyl[1]-benzothieno[3,2-b][1]benzothiophene:poly(indacenodithiophene-co-benzothiadiazole) (C8-BTBT:C16-IDTBT), for which hole mobilities of 8 and 11 cm(2) V-1 s(-1), respectively, are obtained. Doping of the 6,13-bis(triisopropylsilylethynyl)pentacene:PTAA blend with B(C6F5)(3) is also shown to increase the maximum hole mobility to 3.7 cm(2) V-1 s(-1). Analysis of the single and multicomponent materials reveals that B(C6F5)(3) plays a dual role, first acting as an efficient p-dopant, and secondly as a microstructure modifier. Semiconductors that undergo simultaneous p-doping and dopant-induced long-range crystallization are found to consistently outperform transistors based on the pristine materials. Our work underscores Lewis acid doping as a generic strategy towards high performance printed organic microelectronics.

  11. Remarkable Enhancement of the Hole Mobility in Several Organic Small-Molecules, Polymers, and Small-Molecule:Polymer Blend Transistors by Simple Admixing of the Lewis Acid p-Dopant B(C6F5)3

    Panidi, Julianna

    2017-10-05

    Improving the charge carrier mobility of solution-processable organic semiconductors is critical for the development of advanced organic thin-film transistors and their application in the emerging sector of printed electronics. Here, a simple method is reported for enhancing the hole mobility in a wide range of organic semiconductors, including small-molecules, polymers, and small-molecule:polymer blends, with the latter systems exhibiting the highest mobility. The method is simple and relies on admixing of the molecular Lewis acid B(C6F5)(3) in the semiconductor formulation prior to solution deposition. Two prototypical semiconductors where B(C6F5)(3) is shown to have a remarkable impact are the blends of 2,8-difluoro-5,11-bis(triethylsilylethynyl)anthradithiophene:poly(triarylamine) (diF-TESADT:PTAA) and 2,7-dioctyl[1]-benzothieno[3,2-b][1]benzothiophene:poly(indacenodithiophene-co-benzothiadiazole) (C8-BTBT:C16-IDTBT), for which hole mobilities of 8 and 11 cm(2) V-1 s(-1), respectively, are obtained. Doping of the 6,13-bis(triisopropylsilylethynyl)pentacene:PTAA blend with B(C6F5)(3) is also shown to increase the maximum hole mobility to 3.7 cm(2) V-1 s(-1). Analysis of the single and multicomponent materials reveals that B(C6F5)(3) plays a dual role, first acting as an efficient p-dopant, and secondly as a microstructure modifier. Semiconductors that undergo simultaneous p-doping and dopant-induced long-range crystallization are found to consistently outperform transistors based on the pristine materials. Our work underscores Lewis acid doping as a generic strategy towards high performance printed organic microelectronics.

  12. Mechanical behavior of 27CD4 and 100C6 steel joints, rapidly welded using dynamic diffusion welding

    Page, G. le; Hourcade, M.; Criqui, B.

    1993-01-01

    A new process, dynamic-diffusion-bonding (DDB) was improved in our laboratory (1). It offers the advantages of both classical diffusion-bonding and rapidity, which is consistent with mass production. It was proven possible to carry out high strength bonds in a very short time: 60 seconds with specimens of 27CD4 steel (diameter=16mm). After bonding, the specimens were heat treated in order to homogeneize the structure along the piece. With the optimal bonding conditions, namely a few seconds at 1060 C, in a nitrogen with 5% hydrogen gas, with a proper surface preparation (Ra=0,04 μm) and under a modulated pressure during the whole bonding process (2,3): a) deformation of the bonded specimens is limited to about 2% of the heated length, b) tensile and torsion behaviour is very good: failure occurs out of the interface. No defect remains across the weld interface, c) the failure energy of joints measured with impact tests is lower than that of the base metal, because of the flatness of the interface and because of the presence of very fine oxide particles in the bond, d) fatigue behaviour (rotating beam tests) of bonded pieces is very good: their fatigue strength (720 MPa: stair case estimation for 5 .10 6 cycles) is very closed to those of unbonded specimens (780 MPa), and the crack initiates out of the interface near a big inclusion. With the 100C6 steel, bonds of the same quality were obtained, and with higher roughness of specimens (Ra=0,15 μm), high quality joints were achieved with a duration of 60 seconds at 1050 C. (orig.)

  13. Engineering temporal accumulation of a low recalcitrance polysaccharide leads to increased C6 sugar content in plant cell walls

    Vega-Sánchez, Miguel E. [Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley CA USA; Loqué, Dominique [Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley CA USA; Lao, Jeemeng [Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley CA USA; Catena, Michela [Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley CA USA; Verhertbruggen, Yves [Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley CA USA; Herter, Thomas [Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley CA USA; Yang, Fan [Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley CA USA; Harholt, Jesper [Department of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg C Denmark; Ebert, Berit [Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley CA USA; Department of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg C Denmark; Baidoo, Edward E. K. [Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley CA USA; Keasling, Jay D. [Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley CA USA; Department of Chemical and Biomolecular Engineering, and Department of Bioengineering, University of California, Berkeley CA USA; Scheller, Henrik V. [Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley CA USA; Department of Plant and Microbial Biology, University of California, Berkeley CA USA; Heazlewood, Joshua L. [Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley CA USA; Ronald, Pamela C. [Joint BioEnergy Institute and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley CA USA; Department of Plant Pathology and the Genome Center, University of California, Davis CA USA

    2015-01-14

    Reduced cell wall recalcitrance and increased C6 monosaccharide content are desirable traits for future biofuel crops, as long as these biomass modifications do not significantly alter normal growth and development. Mixed-linkage glucan (MLG), a cell wall polysaccharide only present in grasses and related species among flowering plants, is comprised of glucose monomers linked by both β-1,3 and β-1,4 bonds. Previous data have shown that constitutive production of MLG in barley (Hordeum vulgare) severely compromises growth and development. Here, we used spatio-temporal strategies to engineer Arabidopsis thaliana plants to accumulate significant amounts of MLG in the cell wall by expressing the rice CslF6 MLG synthase using secondary cell wall and senescence-associated promoters. Results using secondary wall promoters were suboptimal. When the rice MLG synthase was expressed under the control of a senescence-associated promoter, we obtained up to four times more glucose in the matrix cell wall fraction and up to a 42% increase in saccharification compared to control lines. Importantly, these plants grew and developed normally. The induction of MLG deposition at senescence correlated with an increase of gluconic acid in cell wall extracts of transgenic plants in contrast to the other approaches presented in this study. MLG produced in Arabidopsis has an altered structure compared to the grass glucan, which likely affects its solubility, while its molecular size is unaffected. The induction of cell wall polysaccharide biosynthesis in senescing tissues offers a novel engineering alternative to enhance cell wall properties of lignocellulosic biofuel crops.

  14. Volumetric spiral chemical shift imaging of hyperpolarized [2-(13) c]pyruvate in a rat c6 glioma model.

    Park, Jae Mo; Josan, Sonal; Jang, Taichang; Merchant, Milton; Watkins, Ron; Hurd, Ralph E; Recht, Lawrence D; Mayer, Dirk; Spielman, Daniel M

    2016-03-01

    MRS of hyperpolarized [2-(13)C]pyruvate can be used to assess multiple metabolic pathways within mitochondria as the (13)C label is not lost with the conversion of pyruvate to acetyl-CoA. This study presents the first MR spectroscopic imaging of hyperpolarized [2-(13)C]pyruvate in glioma-bearing brain. Spiral chemical shift imaging with spectrally undersampling scheme (1042 Hz) and a hard-pulse excitation was exploited to simultaneously image [2-(13)C]pyruvate, [2-(13)C]lactate, and [5-(13)C]glutamate, the metabolites known to be produced in brain after an injection of hyperpolarized [2-(13)C]pyruvate, without chemical shift displacement artifacts. A separate undersampling scheme (890 Hz) was also used to image [1-(13)C]acetyl-carnitine. Healthy and C6 glioma-implanted rat brains were imaged at baseline and after dichloroacetate administration, a drug that modulates pyruvate dehydrogenase kinase activity. The baseline metabolite maps showed higher lactate and lower glutamate in tumor as compared to normal-appearing brain. Dichloroacetate led to an increase in glutamate in both tumor and normal-appearing brain. Dichloroacetate-induced %-decrease of lactate/glutamate was comparable to the lactate/bicarbonate decrease from hyperpolarized [1-(13)C]pyruvate studies. Acetyl-carnitine was observed in the muscle/fat tissue surrounding the brain. Robust volumetric imaging with hyperpolarized [2-(13)C]pyruvate and downstream products was performed in glioma-bearing rat brains, demonstrating changes in mitochondrial metabolism with dichloroacetate. © 2015 Wiley Periodicals, Inc.

  15. A multi-parametric imaging investigation of the response of C6 glioma xenografts to MLN0518 (tandutinib treatment.

    Jessica K R Boult

    Full Text Available Angiogenesis, the development of new blood vessels, is essential for tumour growth; this process is stimulated by the secretion of numerous growth factors including platelet derived growth factor (PDGF. PDGF signalling, through its receptor platelet derived growth factor receptor (PDGFR, is involved in vessel maturation, stimulation of angiogenesis and upregulation of other angiogenic factors, including vascular endothelial growth factor (VEGF. PDGFR is a promising target for anti-cancer therapy because it is expressed on both tumour cells and stromal cells associated with the vasculature. MLN0518 (tandutinib is a potent inhibitor of type III receptor tyrosine kinases that demonstrates activity against PDGFRα/β, FLT3 and c-KIT. In this study a multi-parametric MRI and histopathological approach was used to interrogate changes in vascular haemodynamics, structural response and hypoxia in C6 glioma xenografts in response to treatment with MLN0518. The doubling time of tumours in mice treated with MLN0518 was significantly longer than tumours in vehicle treated mice. The perfused vessel area, number of alpha smooth muscle actin positive vessels and hypoxic area in MLN0518 treated tumours were also significantly lower after 10 days treatment. These changes were not accompanied by alterations in vessel calibre or fractional blood volume as assessed using susceptibility contrast MRI. Histological assessment of vessel size and total perfused area did not demonstrate any change with treatment. Intrinsic susceptibility MRI did not reveal any difference in baseline R2* or carbogen-induced change in R2*. Dynamic contrast-enhanced MRI revealed anti-vascular effects of MLN0518 following 3 days treatment. Hypoxia confers chemo- and radio-resistance, and alongside PDGF, is implicated in evasive resistance to agents targeted against VEGF signalling. PDGFR antagonists may improve potency and efficacy of other therapeutics in combination. This study highlights

  16. A multi-parametric imaging investigation of the response of C6 glioma xenografts to MLN0518 (tandutinib) treatment.

    Boult, Jessica K R; Terkelsen, Jennifer; Walker-Samuel, Simon; Bradley, Daniel P; Robinson, Simon P

    2013-01-01

    Angiogenesis, the development of new blood vessels, is essential for tumour growth; this process is stimulated by the secretion of numerous growth factors including platelet derived growth factor (PDGF). PDGF signalling, through its receptor platelet derived growth factor receptor (PDGFR), is involved in vessel maturation, stimulation of angiogenesis and upregulation of other angiogenic factors, including vascular endothelial growth factor (VEGF). PDGFR is a promising target for anti-cancer therapy because it is expressed on both tumour cells and stromal cells associated with the vasculature. MLN0518 (tandutinib) is a potent inhibitor of type III receptor tyrosine kinases that demonstrates activity against PDGFRα/β, FLT3 and c-KIT. In this study a multi-parametric MRI and histopathological approach was used to interrogate changes in vascular haemodynamics, structural response and hypoxia in C6 glioma xenografts in response to treatment with MLN0518. The doubling time of tumours in mice treated with MLN0518 was significantly longer than tumours in vehicle treated mice. The perfused vessel area, number of alpha smooth muscle actin positive vessels and hypoxic area in MLN0518 treated tumours were also significantly lower after 10 days treatment. These changes were not accompanied by alterations in vessel calibre or fractional blood volume as assessed using susceptibility contrast MRI. Histological assessment of vessel size and total perfused area did not demonstrate any change with treatment. Intrinsic susceptibility MRI did not reveal any difference in baseline R2* or carbogen-induced change in R2*. Dynamic contrast-enhanced MRI revealed anti-vascular effects of MLN0518 following 3 days treatment. Hypoxia confers chemo- and radio-resistance, and alongside PDGF, is implicated in evasive resistance to agents targeted against VEGF signalling. PDGFR antagonists may improve potency and efficacy of other therapeutics in combination. This study highlights the challenges

  17. Ways of Telecommunications Interaction Arrangement for Microprocessor Devices of Different Types in Composition of Multi-Motor Electric Drives

    Shpenst, V. A.; Vasiliev, B. Y.; Kalashnikov, O. V.; Oleynikova, A. M.

    2018-05-01

    The article covers a consideration of various state-of-the-art industrial data transfer protocols, e.g. Modbus, Profibus, Industrial Ethernet and CAN. Their pros and cons are analyzed and conclusions made on advisability of the use of each protocol. It is shown that for the arrangement of effective telecommunication interaction of microprocessor devices of different types in the composition of multi-motor electric drives, it is advisable to use highlevel CAN-protocols, such as CANopen and DeviceNet.

  18. The effects of environmental factors and experimental method on the results of low dose rate microprocessor irradiation tests

    Laviron, A; Gerard, G [Commissariat a l' Energie Atomique, IPSN, Centre d' Etudes de Valduc, Is-sur-Tille (France); Gauthier, G; Henry, J Y; Le Meur, M [Commissariat a l' Energie Atomique, IPSN, Fontenay-aux-Roses (France)

    1992-02-01

    As part of the safety studies of nuclear facilities, a series of experiments have been in progress over a number of years to determine the principal parameters for which allowance needs to be made in the testing of microprocessors in low dose rate nuclear irradiation environments. This paper contains a brief description of the results already published, followed by a review of the latest results obtained, specifically as concerns the effects of temperature, the origin of the batch, the angle of incidence of the radiation and the test routine used. (author)

  19. Use of a bipolar microprocessor in a multi-window discriminator for a system studying reactor fuel pins

    Frueh, J.

    1977-01-01

    An automatic evaluation system for non-destructive reactor fuel rod analysis is described. The characteristic γ radiation of certain radioisotopes is measured, and the isotope concentration is derived from this. To determine the radioisotope concentration, a digital multi-window discriminator is installed in the system to isolate the desired γ lines from the total spectrum; in addition, background subtraction is carried out. The multi-window discriminator was constructed of bipolar bit-slice microprocessor modules. A microinstruction set of 4 basic commands was defined by which the functional sequences in the instrument were programmed. (orig.) [de

  20. Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2.

    Jennifer H Stuart

    2016-12-01

    Full Text Available The type I interferon (IFN response is a crucial innate immune signalling pathway required for defense against viral infection. Accordingly, the great majority of mammalian viruses possess means to inhibit this important host immune response. Here we show that vaccinia virus (VACV strain Western Reserve protein C6, is a dual function protein that inhibits the cellular response to type I IFNs in addition to its published function as an inhibitor of IRF-3 activation, thereby restricting type I IFN production from infected cells. Ectopic expression of C6 inhibits the induction of interferon stimulated genes (ISGs in response to IFNα treatment at both the mRNA and protein level. C6 inhibits the IFNα-induced Janus kinase/signal transducer and activator of transcription (JAK/STAT signalling pathway at a late stage, downstream of STAT1 and STAT2 phosphorylation, nuclear translocation and binding of the interferon stimulated gene factor 3 (ISGF3 complex to the interferon stimulated response element (ISRE. Mechanistically, C6 associates with the transactivation domain of STAT2 and this might explain how C6 inhibits the type I IFN signalling very late in the pathway. During virus infection C6 reduces ISRE-dependent gene expression despite the presence of the viral protein phosphatase VH1 that dephosphorylates STAT1 and STAT2. The ability of a cytoplasmic replicating virus to dampen the immune response within the nucleus, and the ability of viral immunomodulators such as C6 to inhibit multiple stages of the innate immune response by distinct mechanisms, emphasizes the intricacies of host-pathogen interactions and viral immune evasion.